Now showing items 1-10 of 18
Current Status and Future Opportunities for Controlling Acromegaly
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-09)
Growth-hormone (GH) secreting adenomas, including acromegaly, account for approximately one-sixth of all pituitary adenomas and are associated with mortality rates at least twice that of the general population. The ultimate ...
Intramedullary Spinal Tumors of Disordered Embryogenesis
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-05)
Abnormal spinal embryogenesis is quite commonplace. While greater than 90 percent of these errors of embryogenesis leads to occult spinal dysraphism with minimal neurologic or orthopedic sequelae, there is a significant ...
Rapid Re-expansion of a Macroprolactinoma After Early Discontinuation of Bromocriptine
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-11)
Prolactin (PRL)-secreting pituitary adenomas are the most common functioning pituitary tumors. Medical treatment with dopamine agonists is the therapy of choice for macroprolactinomas (≥10 mm). Withdrawal of bromocriptine ...
Pergolide As Primary Therapy for Macroprolactinomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-12)
The objective of this study is to determine whether pergolide therapy is an effective modality for the de novo treatment of patients with macroprolactinomas. Twenty-two consecutive patients with macroprolactinomas were ...
Medical Management of Growth Hormone-Secreting Pituitary Adenomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-06)
The primary treatment of acromegaly remains transsphenoidal adenomectomy, yet the tissue overgrowth of acromegaly often progresses following surgery, and responds to radiotherapy only after significant delay. Persistently ...
Effect of dietary vitamin A or N-acetylcysteine on ethylnitrosourea-induced rat gliomas
(Kluwer Academic Publishers; Springer Science+Business Media, 1998-10)
It is our hypothesis that low grade gliomas are the glial counterparts of other precancerous lesions such as colon polyps and, therefore, suitable targets for chemoprevention. Steps in the molecular progression of gliomas ...
GH Receptor Antagonist: Mechanism of Action and Clinical Utility
(Kluwer Academic Publishers; Springer Science+Business Media, Inc., 2005-01)
This review focuses on the development of GH receptor antagonist as a novel agent for treatment of acromegaly, its mechanism of action and potential areas of use. A brief overview of acromegaly, its diagnosis and existing ...
Effect of chronic octreotide treatment on intestinal absorption in patients with acromegaly
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1993-02)
The adverse gastrointestinal effects of octreotide, a synthetic analog of somatostatin, have not been fully elucidated. Low-dose octreotide frequently causes adverse gastrointestinal symptoms in normal individuals. We ...
Magnetic Resonance Imaging of Ethyl-nitrosourea-induced Rat Gliomas: A Model for Experimental Therapeutics of Low-grade Gliomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-07)
Human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of ...