Now showing items 1-9 of 9
Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element
(Wiley Subscription Services, Inc., A Wiley Company, 2009-08-15)
A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 ...
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
(Springer-Verlag, 2006-04)
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive ...
Vesicular neurotransmitter transporters in Huntington's disease: Initial observations and comparison with traditional synaptic markers
(John Wiley & Sons, Inc., 2001-09-15)
Markers of identified neuronal populations have previously suggested selective degeneration of projection neurons in Huntington's disease (HD) striatum. Interpretations are, however, limited by effects of compensatory ...
Transient 23–30 Hz oscillations in mouse hippocampus during exploration of novel environments
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05)
The hippocampus is a key brain structure for the encoding of new experiences and environments. Hippocampal activity shows distinct oscillatory patterns, but the relationships between oscillations and memory are not well ...
Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [ 11 C]NMPB and PET
(John Wiley & Sons, Inc., 2001-03-15)
Cerebral cholinergic deficits have been described in Alzheimer disease (AD) and as a result of normal aging. At the present time, there are very limited options for the quantification of cholinergic receptors with in vivo ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Mutual Potential of Homogeneous Polyhedra
(Kluwer Academic Publishers; Springer, 2005-03)
The mutual gravitational potential between a pair of homogeneous polyhedra is expressed using an infinite series. The nested volume integrals are evaluated analytically and result in simple tensor expressions containing ...
Changes in Gait Variability Across the Lifespan in Persons with Down Syndrome.
(2009)
Variability is always present during repetitive movements. Scholars have studied human movement patterns for years, but have only recently begun to focus on variability as something other than noise or error. I followed ...