Chronic Kidney Disease and Cognitive Function in Older Adults: Findings from the Chronic Renal Insufficiency Cohort Cognitive Study
dc.contributor.author | Yaffe, Kristine | en_US |
dc.contributor.author | Ackerson, Lynn M. | en_US |
dc.contributor.author | Tamura, Manjula kurella | en_US |
dc.contributor.author | Le blanc, Patti | en_US |
dc.contributor.author | Kusek, John W. | en_US |
dc.contributor.author | Sehgal, Ashwini R. | en_US |
dc.contributor.author | Cohen, Debbie | en_US |
dc.contributor.author | Anderson, Cheryl | en_US |
dc.contributor.author | Appel, Lawrence | en_US |
dc.contributor.author | Desalvo, Karen | en_US |
dc.contributor.author | Ojo, Akinlolu O. | en_US |
dc.contributor.author | Seliger, Stephen | en_US |
dc.contributor.author | Robinson, Nancy | en_US |
dc.contributor.author | Makos, Gail | en_US |
dc.contributor.author | Go, Alan S. | en_US |
dc.date.accessioned | 2011-01-13T19:41:10Z | |
dc.date.available | 2011-01-13T19:41:10Z | |
dc.date.issued | 2010-02 | en_US |
dc.identifier.citation | Yaffe, Kristine; Ackerson, Lynn; Tamura, Manjula kurella; Le blanc, Patti; Kusek, John W.; Sehgal, Ashwini R.; Cohen, Debbie; Anderson, Cheryl; Appel, Lawrence; Desalvo, Karen; Ojo, Akinlolu; Seliger, Stephen; Robinson, Nancy; Makos, Gail; Go, Alan S.; (2010). "Chronic Kidney Disease and Cognitive Function in Older Adults: Findings from the Chronic Renal Insufficiency Cohort Cognitive Study." Journal of the American Geriatrics Society 58(2): 338-345. <http://hdl.handle.net/2027.42/78647> | en_US |
dc.identifier.issn | 0002-8614 | en_US |
dc.identifier.issn | 1532-5415 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78647 | |
dc.description.abstract | To investigate cognitive impairment in older, ethnically diverse individuals with a broad range of kidney function, to evaluate a spectrum of cognitive domains, and to determine whether the relationship between chronic kidney disease (CKD) and cognitive function is independent of demographic and clinical factors.Cross-sectional.Chronic Renal Insufficiency Cohort Study.Eight hundred twenty-five adults aged 55 and older with CKD.Estimated glomerular filtration rate (eGFR, mL/min per 1.73 m 2 ) was estimated using the four-variable Modification of Diet in Renal Disease equation. Cognitive scores on six cognitive tests were compared across eGFR strata using linear regression; multivariable logistic regression was used to examine level of CKD and clinically significant cognitive impairment (score ≤1 standard deviations from the mean).Mean age of the participants was 64.9, 50.4% were male, and 44.5% were black. After multivariable adjustment, participants with lower eGFR had lower cognitive scores on most cognitive domains ( P <.05). In addition, participants with advanced CKD (eGFR<30) were more likely to have clinically significant cognitive impairment on global cognition (adjusted odds ratio (AOR) 2.0, 95% CI=1.1–3.9), naming (AOR=1.9, 95% CI=1.0–3.3), attention (AOR=2.4, 95% CI=1.3–4.5), executive function (AOR=2.5, 95% CI=1.9–4.4), and delayed memory (AOR=1.5, 95% CI=0.9–2.6) but not on category fluency (AOR=1.1, 95% CI=0.6–2.0) than those with mild to moderate CKD (eGFR 45–59).In older adults with CKD, lower level of kidney function was associated with lower cognitive function on most domains. These results suggest that older patients with advanced CKD should be screened for cognitive impairment. | en_US |
dc.format.extent | 137444 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.subject.other | Chronic Kidney Disease | en_US |
dc.subject.other | Cognitive Impairment | en_US |
dc.subject.other | Cognitive Function | en_US |
dc.title | Chronic Kidney Disease and Cognitive Function in Older Adults: Findings from the Chronic Renal Insufficiency Cohort Cognitive Study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Nephrology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Psychiatry | en_US |
dc.contributor.affiliationother | Neurology | en_US |
dc.contributor.affiliationother | Epidemiology and Biostatistics, School of Medicine, University of California at San Francisco, San Francisco, California | en_US |
dc.contributor.affiliationother | San Francisco Veterans Affairs Medical Center, San Francisco, California | en_US |
dc.contributor.affiliationother | Division of Research, Kaiser Permanente, Oakland, California | en_US |
dc.contributor.affiliationother | Division of Nephrology, Stanford University School of Medicine, Palo Alto, California | en_US |
dc.contributor.affiliationother | National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; Departments of | en_US |
dc.contributor.affiliationother | Medicine | en_US |
dc.contributor.affiliationother | Biomedical Ethics, and | en_US |
dc.contributor.affiliationother | Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania; Departments of | en_US |
dc.contributor.affiliationother | Epidemiology | en_US |
dc.contributor.affiliationother | Medicine, and | en_US |
dc.contributor.affiliationother | International Health, Johns Hopkins University, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Department of Medicine, School of Medicine, Tulane University, New Orleans, Los Angeles | en_US |
dc.contributor.affiliationother | Division of Nephrology, School of Medicine, University of Maryland, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | St. Clair Specialty Physicians, P.C., Chronic Kidney Disease Clinic, Detroit, Michigan | en_US |
dc.identifier.pmid | 20374407 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78647/1/j.1532-5415.2009.02670.x.pdf | |
dc.identifier.doi | 10.1111/j.1532-5415.2009.02670.x | en_US |
dc.identifier.source | Journal of the American Geriatrics Society | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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