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The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B

dc.contributor.authorLapinski, Philip E.en_US
dc.contributor.authorOliver, Jennifer A.en_US
dc.contributor.authorBodie, Jennifer N.en_US
dc.contributor.authorMarti, Francescen_US
dc.contributor.authorKing, Philip D.en_US
dc.date.accessioned2011-01-13T19:41:19Z
dc.date.available2011-01-13T19:41:19Z
dc.date.issued2009-11en_US
dc.identifier.citationLapinski, Philip E.; Oliver, Jennifer A.; Bodie, Jennifer N.; Marti, Francesc; King, Philip D.; (2009). "The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B." Immunological Reviews 232(1 Organization of Immunoreceptor Signaling by Adapters ): 240-254. <http://hdl.handle.net/2027.42/78649>en_US
dc.identifier.issn0105-2896en_US
dc.identifier.issn1600-065Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/78649
dc.description.abstractAdapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.en_US
dc.format.extent170297 bytes
dc.format.extent3106 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.subject.otherAdapter Proteinsen_US
dc.subject.otherProtein Tyrosine Kinasesen_US
dc.subject.otherSignal Transductionen_US
dc.subject.otherT Lymphocytesen_US
dc.subject.otherAutoimmunityen_US
dc.subject.otherKnockout Miceen_US
dc.titleThe T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4Ben_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.identifier.pmid19909368en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78649/1/j.1600-065X.2009.00829.x.pdf
dc.identifier.doi10.1111/j.1600-065X.2009.00829.xen_US
dc.identifier.sourceImmunological Reviewsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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