Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: a proof-of-concept study
dc.contributor.author | Salvi, Giovanni E. | en_US |
dc.contributor.author | Franco, Lea M. | en_US |
dc.contributor.author | Braun, Thomas M. | en_US |
dc.contributor.author | Lee, Angie | en_US |
dc.contributor.author | Rutger Persson, Gösta | en_US |
dc.contributor.author | Lang, Niklaus P. | en_US |
dc.contributor.author | Giannobile, William V. | en_US |
dc.date.accessioned | 2011-01-13T19:43:08Z | |
dc.date.available | 2011-01-13T19:43:08Z | |
dc.date.issued | 2010-01 | en_US |
dc.identifier.citation | Salvi, Giovanni E.; Franco, Lea M.; Braun, Thomas M.; Lee, Angie; Rutger persson, Gösta; Lang, Niklaus P.; Giannobile, William V.; (2010). "Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: a proof-of-concept study." Journal of Clinical Periodontology 37(1): 9-16. <http://hdl.handle.net/2027.42/78676> | en_US |
dc.identifier.issn | 0303-6979 | en_US |
dc.identifier.issn | 1600-051X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78676 | |
dc.description.abstract | Salvi GE, Franco LM, Braun TM, Lee A, Rutger Persson G, Lang NP, Giannobile WV. Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: a proof-of-concept study. J Clin Periodontol 2010; 37: 9–16. doi: 10.1111/j.1600-051X.2009.01500.x .To compare gingival crevicular fluid (GCF) biomarker levels and microbial distribution in plaque biofilm (SP) samples for subjects with type 1 diabetes (T1DM) versus healthy subjects without diabetes during experimental gingivitis (EG).A total of nine T1DM patients and nine healthy controls of age and gender similar to the T1DM patients were monitored for 35 days during EG. Hygiene practices were stopped for 3 weeks, and GCF, SP, plaque index (PI) and gingival index were determined. IL-1 β , IL-8, MMP-8 and MMP-9 were quantified by enzyme-linked immunosorbent assay, and SP samples were assessed by DNA–DNA hybridization for a panel of 40 subgingival microbial species.IL-1 β levels in T1DM patients were elevated compared with healthy individuals, and showed differences between groups at 7–21 days while healthy patients showed IL-1 β increases from baseline to 14–21 days ( p <0.05). Differences were observed in MMP-9 levels between patients with and without T1DM at 7–14 days ( p <0.05). Orange complex species and PI measurements displayed a superior correlation with biomarker levels when compared with other complexes or clinical measurements during EG.The mean GCF biomarker levels for IL-1 β and MMP-8 were most significantly elevated in T1DM subjects compared with healthy individuals during EG, not resulting from differences in the mean PI or microbial composition. | en_US |
dc.format.extent | 222184 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Biomarker | en_US |
dc.subject.other | Diabetes | en_US |
dc.subject.other | Gingival Crevicular Fluid | en_US |
dc.subject.other | Gingivitis | en_US |
dc.subject.other | IL-1 β | en_US |
dc.subject.other | MMP | en_US |
dc.title | Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: a proof-of-concept study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI, USA ; | en_US |
dc.contributor.affiliationother | Department of Periodontology, University of Bern, Bern, Switzerland ; | en_US |
dc.contributor.affiliationother | The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong, SAR, China | en_US |
dc.identifier.pmid | 19958441 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78676/1/JCPE_1500_sm_supplFigs1.pdf | |
dc.identifier.doi | 10.1111/j.1600-051X.2009.01500.x | en_US |
dc.identifier.source | Journal of Clinical Periodontology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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