Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans
dc.contributor.author | Valiña-Tóth, Anna Liza B. | en_US |
dc.contributor.author | Lai, Zongshan | en_US |
dc.contributor.author | Yoo, Wonsuk | en_US |
dc.contributor.author | Abou-Samra, Abdul | en_US |
dc.contributor.author | Gadegbeku, Crystal A | en_US |
dc.contributor.author | Flack, John M. | en_US |
dc.date.accessioned | 2011-01-31T17:26:21Z | |
dc.date.available | 2011-07-05T19:03:09Z | en_US |
dc.date.issued | 2010-05 | en_US |
dc.identifier.citation | Valiña-Tóth, Anna Liza B.; Lai, Zongshan; Yoo, Wonsuk; Abou-Samra, Abdul; Gadegbeku, Crystal A.; Flack, John M.; (2010). "Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans." Clinical Endocrinology 72(5): 595-603. <http://hdl.handle.net/2027.42/79084> | en_US |
dc.identifier.issn | 0300-0664 | en_US |
dc.identifier.issn | 1365-2265 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79084 | |
dc.description.abstract | Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known.To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures.A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial.Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH.Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total ( P = 0·02), truncal ( P = 0·03) and extremity ( P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass ( P = 0·02). Total fat mass in groups 1–3, respectively, was 30·0, 34·0 and 37·4 kg ( P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg ( P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg ( P = 0·02). Lean mass did not differ across the three groups.Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA. | en_US |
dc.format.extent | 165664 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.title | Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Physiology | en_US |
dc.contributor.affiliationother | Division of Translational Research and Clinical Epidemiology, Department of Internal Medicine | en_US |
dc.contributor.affiliationother | Division of Endocrinology, Department of Internal Medicine, School of Medicine, Wayne State University, Detroit | en_US |
dc.identifier.pmid | 19656160 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79084/1/j.1365-2265.2009.03676.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2265.2009.03676.x | en_US |
dc.identifier.source | Clinical Endocrinology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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