Atypical fibroxanthoma with lymphomatoid reaction
dc.contributor.author | Zheng, Rui | en_US |
dc.contributor.author | Ma, Linglei | en_US |
dc.contributor.author | Bichakjian, Christopher K. | en_US |
dc.contributor.author | Lowe, Lori | en_US |
dc.contributor.author | Fullen, Douglas R. | en_US |
dc.date.accessioned | 2011-01-31T17:34:16Z | |
dc.date.available | 2012-03-05T15:30:01Z | en_US |
dc.date.issued | 2011-01 | en_US |
dc.identifier.citation | Zheng, Rui; Ma, Linglei; Bichakjian, Christopher K.; Lowe, Lori; Fullen, Douglas R.; (2011). "Atypical fibroxanthoma with lymphomatoid reaction." Journal of Cutaneous Pathology 38(1): 8-13. <http://hdl.handle.net/2027.42/79152> | en_US |
dc.identifier.issn | 0303-6987 | en_US |
dc.identifier.issn | 1600-0560 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79152 | |
dc.description.abstract | Background: Atypical fibroxanthoma (AFX) represents an uncommon skin tumor typically occurring on sun-damaged skin of the elderly. Histopathologic variants include spindled, clear cell, osteoid, osteoclastic, chondroid, pigmented, granular cell and myxoid lesions. To date, an atypical lymphoid infiltrate, including CD30-positive large cells mimicking lymphomatoid papulosis, has not been described in association with AFX. Methods: The clinical and histopathological characteristics of two AFX cases inciting an atypical lymphoid infiltrate, along with immunohistochemical profiles and T-cell receptor gamma ( TCR γ) gene rearrangement results, were reviewed. Results: Lesions in both cases occurred as solitary nodules in elderly patients. Microscopically, both lesions showed a cellular proliferation composed of pleomorphic spindle cells, associated with a prominent intralesional atypical lymphoid infiltrate. The spindle cells expressed CD10 but lacked the expression of S-100, cytokeratins and muscle markers, thereby confirming the diagnosis of AFX. CD30 highlighted a significant subset of large mononuclear cells in the lymphoid infiltrate of one case. TCR γ gene rearrangement analyses were negative for both cases. Conclusion: An atypical lymphoid infiltrate, including the one resembling lymphomatoid papulosis, associated with AFX has not been previously described. It is important to recognize the reactive nature of the infiltrate to avoid a misdiagnosis of lymphoma.Zheng R, Ma L, Bichakjian CK, Lowe L, Fullen DR. Atypical fibroxanthoma with lymphomatoid reaction. | en_US |
dc.format.extent | 1163546 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.title | Atypical fibroxanthoma with lymphomatoid reaction | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dermatology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Dermatology, The First Hospital of Shanxi Medical University, Taiyuan, China | en_US |
dc.identifier.pmid | 21039743 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79152/1/j.1600-0560.2010.01622.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-0560.2010.01622.x | en_US |
dc.identifier.source | Journal of Cutaneous Pathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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