Glomerular Filtration Rate Following Pediatric Liver Transplantation—The SPLIT Experience
dc.contributor.author | Campbell, K. | en_US |
dc.contributor.author | Ng, V. | en_US |
dc.contributor.author | Martin, S. | en_US |
dc.contributor.author | Magee, John C. | en_US |
dc.contributor.author | Goebel, J. | en_US |
dc.contributor.author | Anand, Ravinder | en_US |
dc.contributor.author | Martz, Karen | en_US |
dc.contributor.author | Bucuvalas, John C. | en_US |
dc.date.accessioned | 2011-01-31T17:49:29Z | |
dc.date.available | 2012-02-21T18:47:01Z | en_US |
dc.date.issued | 2010-12 | en_US |
dc.identifier.citation | Campbell, K.; Ng, V.; Martin, S.; Magee, J.; Goebel, J.; Anand, R.; Martz, K.; Bucuvalas, J.; (2010). "Glomerular Filtration Rate Following Pediatric Liver Transplantation—The SPLIT Experience." American Journal of Transplantation 10(12): 2673-2682. <http://hdl.handle.net/2027.42/79286> | en_US |
dc.identifier.issn | 1600-6135 | en_US |
dc.identifier.issn | 1600-6143 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79286 | |
dc.description.abstract | Impaired kidney function is a well-recognized complication following liver transplantation (LT). Studies of this complication in children have been limited by small numbers and insensitive outcome measures. Our aim was to define the prevalence of, and identify risk factors for, post-LT kidney dysfunction in a multicenter pediatric cohort using measured glomerular filtration rate (mGFR). We conducted a cross-sectional study of 397 patients enrolled in the Studies in Pediatric Liver Transplantation (SPLIT) registry, using mGFR < 90 mL/min/1.73 m 2 as the primary outcome measure. Median age at LT was 2.2 years. Primary diagnoses were biliary atresia (44.6%), fulminant liver failure (9.8%), metabolic liver disease (16.4%), chronic cholestatic liver disease (13.1%), cryptogenic cirrhosis (4.3%) and other (11.8%). At a mean of 5.2 years post-LT, 17.6% of patients had a mGFR < 90 mL/min/1.73 m 2 . In univariate analysis, factors associated with this outcome were transplant center, age at LT, primary diagnosis, calculated GFR (cGFR) at LT and 12 months post-LT, primary immunosuppression, early post-LT kidney complications, age at mGFR, height and weight Z-scores at 12 months post-LT. In multivariate analysis, independent variables associated with a mGFR <90 mL/min/1.73 m 2 were primary immunosuppression, age at LT, cGFR at LT and height Z-score at 12 months post-LT. | en_US |
dc.format.extent | 219290 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.subject.other | Glomerular Filtration Rate | en_US |
dc.subject.other | Multicenter Studies | en_US |
dc.subject.other | Pediatric Liver Transplantation | en_US |
dc.subject.other | Long-term Outcomes | en_US |
dc.subject.other | Renal Dysfunction | en_US |
dc.title | Glomerular Filtration Rate Following Pediatric Liver Transplantation—The SPLIT Experience | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Health System, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Cincinnati Children's Hospital Medical Center, Cincinnati, OH | en_US |
dc.contributor.affiliationother | The Hospital for Sick Children, Toronto, Canada | en_US |
dc.contributor.affiliationother | CHU Sainte-Justine, Montreal, Canada | en_US |
dc.contributor.affiliationother | The EMMES Corporation, Rockville, MD Supported by National Institutes of Health (U01 DK061693-01A1). Additional support provided by Astellas Pharma US, Inc, and Roche Laboratories. | en_US |
dc.identifier.pmid | 21114644 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79286/1/j.1600-6143.2010.03316.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-6143.2010.03316.x | en_US |
dc.identifier.source | American Journal of Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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