Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism
dc.contributor.author | Chiu, Hsiu-Ju | en_US |
dc.contributor.author | Bakolitsa, Constantina | en_US |
dc.contributor.author | Skerra, Arne | en_US |
dc.contributor.author | Lomize, Andrei L. | en_US |
dc.contributor.author | Carlton, Dennis | en_US |
dc.contributor.author | Miller, Mitchell D. | en_US |
dc.contributor.author | Krishna, S. Sri | en_US |
dc.contributor.author | Abdubek, Polat | en_US |
dc.contributor.author | Astakhova, Tamara | en_US |
dc.contributor.author | Axelrod, Herbert L. | en_US |
dc.contributor.author | Clayton, Thomas | en_US |
dc.contributor.author | Deller, Marc C. | en_US |
dc.contributor.author | Duan, Lian | en_US |
dc.contributor.author | Feuerhelm, Julie | en_US |
dc.contributor.author | Grant, Joanna C. | en_US |
dc.contributor.author | Grzechnik, Slawomir K. | en_US |
dc.contributor.author | Han, Gye Won | en_US |
dc.contributor.author | Jaroszewski, Lukasz | en_US |
dc.contributor.author | Jin, Kevin K. | en_US |
dc.contributor.author | Klock, Heath E. | en_US |
dc.contributor.author | Knuth, Mark W. | en_US |
dc.contributor.author | Kozbial, Piotr | en_US |
dc.contributor.author | Kumar, Abhinav | en_US |
dc.contributor.author | Marciano, David | en_US |
dc.contributor.author | Mcmullan, Daniel | en_US |
dc.contributor.author | Morse, Andrew T. | en_US |
dc.contributor.author | Nigoghossian, Edward | en_US |
dc.contributor.author | Okach, Linda | en_US |
dc.contributor.author | Paulsen, Jessica | en_US |
dc.contributor.author | Reyes, Ron | en_US |
dc.contributor.author | Rife, Christopher L. | en_US |
dc.contributor.author | Van Den Bedem, Henry | en_US |
dc.contributor.author | Weekes, Dana | en_US |
dc.contributor.author | Xu, Qingping | en_US |
dc.contributor.author | Hodgson, Keith O. | en_US |
dc.contributor.author | Wooley, John | en_US |
dc.contributor.author | Elsliger, Marc-André | en_US |
dc.contributor.author | Deacon, Ashley M. | en_US |
dc.contributor.author | Godzik, Adam | en_US |
dc.contributor.author | Lesley, Scott A. | en_US |
dc.contributor.author | Wilson, Ian A. | en_US |
dc.date.accessioned | 2011-01-31T17:56:28Z | |
dc.date.available | 2011-12-02T15:41:52Z | en_US |
dc.date.issued | 2010-10-01 | en_US |
dc.identifier.citation | Chiu, Hsiu-Ju; Bakolitsa, Constantina; Skerra, Arne; Lomize, Andrei; Carlton, Dennis; Miller, Mitchell D.; Krishna, S. Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Slawomir K.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Kumar, Abhinav; Marciano, David; Mcmullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L.; Van Den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.; (2010). "Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism." Acta Crystallographica Section F 66(10): 1153-1159. <http://hdl.handle.net/2027.42/79347> | en_US |
dc.identifier.issn | 1744-3091 | en_US |
dc.identifier.issn | 1744-3091 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79347 | |
dc.description.abstract | The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively. | en_US |
dc.format.extent | 1362447 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | International Union of Crystallography | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Structural Genomics | en_US |
dc.subject.other | Domains of Unknown Function | en_US |
dc.subject.other | Calycin | en_US |
dc.subject.other | Lipocalin | en_US |
dc.subject.other | Fatty-acid Binding Proteins | en_US |
dc.title | Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationother | Joint Center for Structural Genomics, http://www.jcsg.org , USA | en_US |
dc.contributor.affiliationother | Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA | en_US |
dc.contributor.affiliationother | Program on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, CA, USA | en_US |
dc.contributor.affiliationother | Lehrstuhl für Biologische Chemie, Technische Universität München, 85350 Freizing-Weihenstephan, Germany | en_US |
dc.contributor.affiliationother | Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA | en_US |
dc.contributor.affiliationother | Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA, USA | en_US |
dc.contributor.affiliationother | Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA | en_US |
dc.contributor.affiliationother | Photon Science, SLAC National Accelerator Laboratory, Menlo Park, CA, USA | en_US |
dc.identifier.pmid | 20944205 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79347/1/S1744309109037749.pdf | |
dc.identifier.doi | 10.1107/S1744309109037749 | en_US |
dc.identifier.source | Acta Crystallographica Section F | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.