Chemokine and Cytokine Mediated Loss of Regulatory T Cells in Lymph Nodes during Pathogenic Simian Immunodeficiency Virus Infection
dc.contributor.author | Shulin, Qin | |
dc.contributor.author | Yongjun, Sui | |
dc.contributor.author | Soloff, Adam C. | |
dc.contributor.author | Fallert Junecko, Beth A. | |
dc.contributor.author | Kirschner, Denise E. | |
dc.contributor.author | Murphey-Corb, Michael A. | |
dc.contributor.author | Watkins, Simon C. | |
dc.contributor.author | Tarwater, Patrick M. | |
dc.contributor.author | Pease, James E. | |
dc.contributor.author | Barratt-Boyes, Simon M. | |
dc.contributor.author | Reinhart, Todd A. | |
dc.date.accessioned | 2011-03-25T12:03:42Z | |
dc.date.accessioned | 2011-03-25T12:03:42Z | |
dc.date.available | 2011-03-25T12:03:42Z | en_US |
dc.date.issued | 2008-02-08 | |
dc.identifier.citation | The Journal of Immunology, 2008, 180: 5530–5536 <http://hdl.handle.net/2027.42/83335> | en_US |
dc.identifier.other | 0022-1767/08 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/83335 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed?term=18390737 | |
dc.description.abstract | Regulatory T cells (Treg) play key roles in immune regulation through multiple modes of suppression. The effects of HIV-1 infection on Treg levels in lymphoid tissues remain incompletely understood. To explore this issue, we have measured the levels of forkhead box protein 3 (FOXP3)-positive cells and associated immunomodulatory genes in a pathogenic simian immunodeficiency virus/macaque model and found that a loss of Treg in lymph nodes occurred following simian immunodeficiency virus infection. Changes in expression of the ligands for CXCR3, CCR4, and CCR7 and the cytokines TGF-Beta and IL-2 were all linked to this loss of Treg, which in turn was linked with increased levels of cellular activation. Our findings identify three mechanisms that likely contribute to SIV-driven loss of Treg, including reduced levels of cytokines associated with Treg differentiation and altered ex- pression of agonist and antagonist chemokines. The loss of Treg and the associated cellular activation in lymphoid tissues is consistent with the events in HIV-1-infected individuals and suggest that components of the Treg differentiation and trafficking network could be targets for therapeutic intervention. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The American Association of Immunologists, Inc. | en_US |
dc.title | Chemokine and Cytokine Mediated Loss of Regulatory T Cells in Lymph Nodes during Pathogenic Simian Immunodeficiency Virus Infection | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Microbiology and Immunology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 18390737 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83335/1/Qin_et_all.2008.5530.pdf | |
dc.identifier.source | The Journal of Immunology | en_US |
dc.owningcollname | Microbiology and Immunology, Department of |
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