Comparison of 123 I-metaiodobenzylguanidine (MIBG) and 131 I-MIBG semi-quantitative scores in predicting survival in patients with stage 4 neuroblastoma: A report from the Children's Oncology Group
dc.contributor.author | Naranjo, Arlene | en_US |
dc.contributor.author | Parisi, Marguerite T. | en_US |
dc.contributor.author | Shulkin, Barry L. | en_US |
dc.contributor.author | London, Wendy B. | en_US |
dc.contributor.author | Matthay, Katherine K. | en_US |
dc.contributor.author | Kreissman, Susan G. | en_US |
dc.contributor.author | Yanik, Gregory A. | en_US |
dc.date.accessioned | 2011-05-06T15:38:36Z | |
dc.date.available | 2012-09-04T15:27:07Z | en_US |
dc.date.issued | 2011-07-01 | en_US |
dc.identifier.citation | Naranjo, Arlene; Parisi, Marguerite T.; Shulkin, Barry L.; London, Wendy B.; Matthay, Katherine K.; Kreissman, Susan G.; Yanik, Gregory A. (2011). "Comparison of 123 I-metaiodobenzylguanidine (MIBG) and 131 I-MIBG semi-quantitative scores in predicting survival in patients with stage 4 neuroblastoma: A report from the Children's Oncology Group." Pediatric Blood & Cancer 56(7): 1041-1045. <http://hdl.handle.net/2027.42/83739> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83739 | |
dc.description.abstract | Background 123 I-metaiodobenzylguanidine (MIBG) scans are preferable to 131 I-MIBG for neuroblastoma imaging as they deliver less patient radiation yet have greater sensitivity in disease detection. Both 123 I-MIBG and 131 I-MIBG scans were used for disease assessments of neuroblastoma patients enrolled on Children's Oncology Group (COG) high-risk study A3973. The hypothesis was that 123 I-MIBG and 131 I-MIBG scans were sufficiently similar for clinical purposes in terms of ability to predict survival. Procedure Patients enrolled on COG A3973 with stage 4 disease who completed 123 I-MIBG or 131 I-MIBG scans at diagnosis, post-induction, post-transplant, or post-biotherapy were analyzed. The performance of the Curie score for each MIBG scan type in predicting survival was evaluated. At each time point, survival curves for 123 I-MIBG versus 131 I-MIBG were compared using the log-rank test. Results Of the 413 patients on A3973 with at least one MIBG scan, 350 were stage 4. The 5-year event-free survival (EFS) and overall survival (OS) rates were 33.4 ± 3.6% and 45.6 ± 4.0% (N = 350). At post-induction, EFS ( P = 0.3501) and OS ( P = 0.5337) for 123 I-MIBG versus 131 I-MIBG were not significantly different. Similarly, comparisons at the three other time points were non-significant. Conclusions We found no evidence of a statistically significant difference in outcome by type of scan. For future survival analyses of MIBG Curie scores, 123 I-MIBG and 131 I-MIBG results may be combined and analyzed overall, without adjustment for scan type. Pediatr Blood Cancer 2011;56:1041–1045. © 2011 Wiley-Liss, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Comparison of 123 I-metaiodobenzylguanidine (MIBG) and 131 I-MIBG semi-quantitative scores in predicting survival in patients with stage 4 neuroblastoma: A report from the Children's Oncology Group | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Children's Oncology Group, University of Florida, Gainesville, Florida ; Children's Oncology Group (COG), University of Florida, 104 N. Main St. Suite 600, Gainesville, FL 32601. | en_US |
dc.contributor.affiliationother | Department of Radiology and Pediatrics, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, Washington | en_US |
dc.contributor.affiliationother | St. Jude Children's Research Hospital Memphis, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | Children's Oncology Group, Children's Hospital Boston/Dana-Farber Cancer Institute, Boston, Massachusetts | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of California San Francisco School of Medicine and UCSF Children's Hospital, San Francisco, California | en_US |
dc.contributor.affiliationother | Duke University Medical Center, Durham, North Carolina | en_US |
dc.identifier.pmid | 21328522 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83739/1/22991_ftp.pdf | |
dc.identifier.doi | 10.1002/pbc.22991 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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