Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection
dc.contributor.author | Corn Minor, Radiah A. | en_US |
dc.contributor.author | Limmon, Gino V. | en_US |
dc.contributor.author | Miller-DeGraff, Laura | en_US |
dc.contributor.author | Dixon, Darlene | en_US |
dc.contributor.author | Andrews, Danica M. K. | en_US |
dc.contributor.author | Kaufman, Randal J. | en_US |
dc.contributor.author | Imani, Farhad | en_US |
dc.date.accessioned | 2011-06-17T20:27:27Z | |
dc.date.available | 2011-06-17T20:27:27Z | |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Corn Minor, Radiah A.; Limmon, Gino V.; Miller-DeGraff, Laura; Dixon, Darlene; Andrews, Danica M.K.; Kaufman, Randal J.; Imani, Farhad (2009/12/28). "Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection." Journal of Interferon & Cytokine Research, 30(4): 263-272 <http://hdl.handle.net/2027.42/85133> | en_US |
dc.identifier.issn | 1079-9907 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/85133 | |
dc.description.abstract | Respiratory syncytial virus (RSV) is the most common cause of childhood viral bronchiolitis and lung injury. Inflammatory responses significantly contribute to lung pathologies during RSV infections and bronchiolitis but the exact mechanisms have not been completely defined. The double-stranded RNA-activated protein kinase (PKR) functions to inhibit viral replication and participates in several signaling pathways associated with innate inflammatory immune responses. Using a functionally defective PKR (PKR?/?) mouse model, we investigated the role of this kinase in early events of RSV-induced inflammation. Our data showed that bronchoalveolar lavage (BAL) fluid from infected PKR?/? mice had significantly lower levels of several innate inflammatory cytokines and chemokines. Histological examinations revealed that there was less lung injury in infected PKR?/? mice as compared to the wild type. A genome-wide analysis showed that several early antiviral and immune regulatory genes were affected by PKR activation. These data suggest that PKR is a signaling molecule for immune responses during RSV infections. | en_US |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 20038207 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/85133/1/jir_2009_0051.pdf | |
dc.identifier.doi | 10.1089/jir.2009.0051 | en_US |
dc.identifier.source | Journal of Interferon & Cytokine Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.