Myogenin regulates denervation‐dependent muscle atrophy in mouse soleus muscle
dc.contributor.author | Macpherson, Peter C. D. | en_US |
dc.contributor.author | Wang, Xun | en_US |
dc.contributor.author | Goldman, Daniel J. | en_US |
dc.date.accessioned | 2011-11-10T15:34:04Z | |
dc.date.available | 2012-10-01T18:34:27Z | en_US |
dc.date.issued | 2011-08 | en_US |
dc.identifier.citation | Macpherson, Peter C. D.; Wang, Xun; Goldman, Daniel (2011). "Myogenin regulates denervation‐dependent muscle atrophy in mouse soleus muscle." Journal of Cellular Biochemistry 112(8): 2149-2159. <http://hdl.handle.net/2027.42/86926> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/86926 | |
dc.description.abstract | Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy‐related genes, like Atrogin‐1 and MuRF‐1, are intimately tied to loss of muscle mass. When these atrophy‐related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle‐specific transcription factor that is highly induced following muscle denervation. To investigate if Myog contributes to muscle atrophy, we have taken advantage of conditional Myog null mice. We show that in the denervated soleus muscle Myog expression contributes to reduced muscle force, mass, and cross‐sectional area. We found that Myog mediates these effects, at least in part, by regulating expression of the Atrogin‐1 and MuRF‐1 genes. Indeed Myog over‐expression in innervated muscle stimulates Atrogin‐1 gene expression and Myog over‐expression stimulates Atrogin‐1 promoter activity. Thus, Myog and the signaling cascades regulating its induction following muscle denervation may represent novel targets for therapies aimed at reducing denervation‐induced muscle atrophy. J. Cell. Biochem. 112: 2149–2159, 2011. © 2011 Wiley‐Liss, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Myogenin | en_US |
dc.subject.other | Atrogin‐1 | en_US |
dc.subject.other | MuRF‐1 | en_US |
dc.subject.other | Muscle Mass | en_US |
dc.subject.other | Muscle Force | en_US |
dc.subject.other | Muscle Cross‐Sectional Area | en_US |
dc.subject.other | Muscle Denervation | en_US |
dc.title | Myogenin regulates denervation‐dependent muscle atrophy in mouse soleus muscle | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, 5045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 21465538 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/86926/1/23136_ftp.pdf | |
dc.identifier.doi | 10.1002/jcb.23136 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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