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Microprinted feeder cells guide embryonic stem cell fate

dc.contributor.authorTavana, Hosseinen_US
dc.contributor.authorMosadegh, Bobaken_US
dc.contributor.authorZamankhan, Parsaen_US
dc.contributor.authorGrotberg, James B.en_US
dc.contributor.authorTakayama, Shuichien_US
dc.date.accessioned2011-11-10T15:34:35Z
dc.date.available2012-12-03T21:17:30Zen_US
dc.date.issued2011-10en_US
dc.identifier.citationTavana, Hossein; Mosadegh, Bobak; Zamankhan, Parsa; Grotberg, James B.; Takayama, Shuichi (2011). "Microprinted feeder cells guide embryonic stem cell fate." Biotechnology and Bioengineering 108(10): 2509-2516. <http://hdl.handle.net/2027.42/86949>en_US
dc.identifier.issn0006-3592en_US
dc.identifier.issn1097-0290en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/86949
dc.description.abstractWe introduce a non‐contact approach to microprint multiple types of feeder cells in a microarray format using immiscible aqueous solutions of two biopolymers. Droplets of cell suspension in the denser aqueous phase are printed on a substrate residing within a bath of the immersion aqueous phase. Due to their affinity to the denser phase, cells remain localized within the drops and adhere to regions of the substrate underneath the drops. We show the utility of this technology for creating duplex heterocellular stem cell niches by printing two different support cell types on a gel surface and overlaying them with mouse embryonic stem cells (mESCs). As desired, the type of printed support cell spatially direct the fate of overlaid mESCs. Interestingly, we found that interspaced mESCs colonies on differentiation‐inducing feeder cells show enhanced neuronal differentiation and give rise to dense networks of neurons. This cell printing technology provides unprecedented capabilities to efficiently identify the role of various feeder cells in guiding the fate of stem cells. Biotechnol. Bioeng. 2011;108: 2509–2516. © 2011 Wiley Periodicals, Inc.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherPolymeric Aqueous Two‐Phase Systemen_US
dc.subject.otherCell Printingen_US
dc.subject.otherCell Microenvironment Engineeringen_US
dc.subject.otherCell–Cell Contacten_US
dc.subject.otherEmbryonic Stem Cell Fateen_US
dc.titleMicroprinted feeder cells guide embryonic stem cell fateen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelMathematicsen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelStatistics and Numeric Dataen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109; telephone: +1‐734‐615‐5539; fax: (734) 936‐1905en_US
dc.contributor.affiliationumDepartment of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109; telephone: +1‐734‐615‐5539; fax: (734) 936‐1905.en_US
dc.contributor.affiliationotherDepartment of Biomedical Engineering, University of Akron, Akron, Ohioen_US
dc.contributor.affiliationotherDivision of Nano‐Bio and Chemical Engineering WCU Project, UNIST, Ulsan, Republic of Koreaen_US
dc.identifier.pmid21538333en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/86949/1/23190_ftp.pdf
dc.identifier.doi10.1002/bit.23190en_US
dc.identifier.sourceBiotechnology and Bioengineeringen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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