View Item 

Show simple item record

Arousal modulation of memory and amygdala‐parahippocampal connectivity: A PET‐psychophysiology study in specific phobia

dc.contributor.authorÅhs, Fredriken_US
dc.contributor.authorPalmquist, Åsa Michelgården_US
dc.contributor.authorPissiota, Annaen_US
dc.contributor.authorAppel, Lieuween_US
dc.contributor.authorFrans, Örjanen_US
dc.contributor.authorLiberzon, Israelen_US
dc.contributor.authorFurmark, Tomasen_US
dc.contributor.authorFredrikson, Matsen_US
dc.date.accessioned2011-11-10T15:35:11Z
dc.date.available2013-01-02T16:32:12Zen_US
dc.date.issued2011-11en_US
dc.identifier.citationÅhs, Fredrik ; Palmquist, Åsa Michelgård ; Pissiota, Anna; Appel, Lieuwe; Frans, Örjan ; Liberzon, Israel; Furmark, Tomas; Fredrikson, Mats (2011). "Arousal modulation of memory and amygdalaâ parahippocampal connectivity: A PETâ psychophysiology study in specific phobia." Psychophysiology 48(11). <http://hdl.handle.net/2027.42/86974>en_US
dc.identifier.issn0048-5772en_US
dc.identifier.issn1469-8986en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/86974
dc.description.abstractPhobic fear is accompanied by intense bodily responses modulated by the amygdala. An amygdala moderated psychophysiological measure related to arousal is electrodermal activity. We evaluated the contributions of electrodermal activity to amygdala‐parahippocampal regional cerebral blood flow (rCBF) during phobic memory encoding in subjects with spider or snake phobia. Recognition memory was increased for phobia‐related slides and covaried with rCBF in the amygdala and the parahippocampal gyrus. The covariation between parahippocampal rCBF and recognition was related to electrodermal activity suggesting that parahippocampal memory processes were associated with sympathetic activity. Electrodermal activity further mediated the amygdala effect on parahippocampal activity. Memory encoding during phobic fear therefore seems contingent on amygdala's influence on arousal and parahippocampal activity.en_US
dc.publisherBlackwell Publishing Incen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherAnxietyen_US
dc.subject.otherLearning/Memoryen_US
dc.subject.otherFMRI/PET/MRIen_US
dc.subject.otherElectrodermalen_US
dc.subject.otherAmygdalaen_US
dc.subject.otherParahippocampal Gyrusen_US
dc.titleArousal modulation of memory and amygdala‐parahippocampal connectivity: A PET‐psychophysiology study in specific phobiaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan School of Natural Resources, Department of Psychiatry, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Psychology, Uppsala University, Uppsala, Swedenen_US
dc.contributor.affiliationotherDepartment of Neuroscience, Psychiatry, Uppsala University, Uppsala, Swedenen_US
dc.contributor.affiliationotherUppsala Imanet, GE Healthcare, Uppsala, Swedenen_US
dc.identifier.pmid21729104en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/86974/1/j.1469-8986.2011.01231.x.pdf
dc.identifier.doi10.1111/j.1469-8986.2011.01231.xen_US
dc.identifier.sourcePsychophysiologyen_US
dc.identifier.citedreferenceAhs, F., Frans, O., Tibblin, B., Kumlien, E., & Fredrikson, M. ( 2010 ). The effects of medial temporal lobe resections on verbal threat and fear conditioning. Biological Psychology, 83, 41 – 46.en_US
dc.identifier.citedreferenceAhs, F., Pissiota, A., Michelgard, A., Frans, O., Furmark, T., Appel, L., & Fredrikson, M. ( 2009 ). Disentangling the web of fear: Amygdala reactivity and functional connectivity in spider and snake phobia. Psychiatry Research-Neuroimaging, 172, 103 – 108.en_US
dc.identifier.citedreferenceAiraksinen, E., Larsson, M., & Forsell, Y. ( 2005 ). Neuropsychological functions in anxiety disorders in population‐based samples: Evidence of episodic memory dysfunction. Journal of Psychiatric Research, 39, 207 – 214.en_US
dc.identifier.citedreferenceAlkire, M. T., Gruver, R., Miller, J., McReynolds, J. R., Hahn, E. L., & Cahill, L. ( 2008 ). Neuroimaging analysis of an anesthetic gas that blocks human emotional memory. Proceedings of the National Academy of Sciences of the United States of America, 105, 1722 – 1727.en_US
dc.identifier.citedreferenceAmerican Psychiatric Association ( 1994 ). Diagnostic and statistical manual of mental disorders ( 4th ed. ). Washington, DC: American Psychiatric Association.en_US
dc.identifier.citedreferenceAndrade, A., Paradis, A. L., Rouquette, S., & Poline, J. B. ( 1999 ). Ambiguous results in functional neuroimaging data analysis due to covariate correlation. NeuroImage, 10, 483 – 486.en_US
dc.identifier.citedreferenceBaron, R. M., & Kenny, D. A. ( 1986 ). The moderator mediator variable distinction in social psychological‐research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173 – 1182.en_US
dc.identifier.citedreferenceBradley, M. M., Greenwald, M. K., Petry, M. C., & Lang, P. J. ( 1992 ). Remembering pictures: Pleasure and arousal in memory. Journal of Experimental Psychology-Learning Memory and Cognition, 18, 379 – 390.en_US
dc.identifier.citedreferenceBradley, M. M., Lang, P. J., & Cuthbert, B. N. ( 1993 ). Emotion, novelty, and the startle reflex: Habituation in humans. Behavioral Neuroscience, 107, 970 – 980.en_US
dc.identifier.citedreferenceBuchanan, T. W., Etzel, J. A., Adolphs, R., & Tranel, D. ( 2006 ). The influence of autonomic arousal and semantic relatedness on memory for emotional words. International Journal of Psychophysiology, 61, 26 – 33.en_US
dc.identifier.citedreferenceCahill, L., Haier, R. J., Fallon, J., Alkire, M. T., Tang, C., Keator, D., … McGaugh, J. L. ( 1996 ). Amygdala activity at encoding correlated with long‐term, free recall of emotional information. Proceedings of the National Academy of Sciences of the United States of America, 93, 8016 – 8021.en_US
dc.identifier.citedreferenceCanli, T., Zhao, Z., Brewer, J., Gabrieli, J. D. E., & Cahill, L. ( 2000 ). Event‐related activation in the human amygdala associates with later memory for individual emotional experience. Journal of Neuroscience, 20, RC99.en_US
dc.identifier.citedreferenceCheng, D. T., Knight, D. C., Smith, C. N., & Helmstetter, F. J. ( 2006 ). Human amygdala activity during the expression of fear responses. Behavioral Neuroscience, 120, 1187 – 1195.en_US
dc.identifier.citedreferenceDavis, M. ( 2006 ). Neural systems involved in fear and anxiety measured with fear‐potentiated startle. American Psychologist, 61, 741 – 756.en_US
dc.identifier.citedreferenceDolcos, F., LaBar, K. S., & Cabeza, R. ( 2004 ). Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: An event‐related fMRI study. NeuroImage, 23, 64 – 74.en_US
dc.identifier.citedreferenceFredrikson, M. ( 1981 ). Orienting and defensive reactions to phobic and conditioned fear stimuli in phobics and normals. Psychophysiology, 18, 456 – 465.en_US
dc.identifier.citedreferenceFredrikson, M. ( 1983 ). Reliability and validity of some specific fear questionnaires. Scandinavian Journal of Psychology, 24, 331 – 334.en_US
dc.identifier.citedreferenceFriston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. B., Frith, C. D., & Frackowiak, R. S. J. ( 1994 ). Statistical parametric maps in functional imaging: A general linear approach. Human Brain Mapping, 2, 189 – 210.en_US
dc.identifier.citedreferenceFischer, H, Wik, G, Larsson, M, & Fredrikson, M ( 1997 ). The amygdala and individual differences in fear conditioning. NeuroReport, 8, 3957 – 3960.en_US
dc.identifier.citedreferenceFusar‐Poli, P., Placentino, A., Carletti, F., Landi, P., Allen, P., Surguladze, S., … Politi, P. ( 2009 ). Functional atlas of emotional faces processing: A voxel‐based meta‐analysis of 105 functional magnetic resonance imaging studies. Journal of Psychiatry and Neuroscience, 34, 418 – 432.en_US
dc.identifier.citedreferenceHalgren, E., Walter, R. D., Cherlow, D. G., & Crandall, P. H. ( 1978 ). Mental phenomena evoked by electrical‐stimulation of human hippocampal formation and amygdala. Brain, 101, 83 – 117.en_US
dc.identifier.citedreferenceHamann, S. B., Ely, T. D., Grafton, S. T., & Kilts, C. D. ( 1999 ). Amygdala activity related to enhanced memory for pleasant and aversive stimuli. Nature Neuroscience, 2, 289 – 293.en_US
dc.identifier.citedreferenceHamm, A. O. ( 2009 ). Specific phobias. Psychiatric Clinics of North America, 32, 577 – 591.en_US
dc.identifier.citedreferenceHamm, A. O., & Weike, A. I. ( 2005 ). The neuropsychology of fear learning and fear regulation. International Journal of Psychophysiology, 57, 5 – 14.en_US
dc.identifier.citedreferenceKensinger, E. A., & Corkin, S. ( 2004 ). Two routes to emotional memory: Distinct neural processes for valence and arousal. Proceedings of the National Academy of Sciences of the United States of America, 101, 3310 – 3315.en_US
dc.identifier.citedreferenceKilpatrick, L., & Cahill, L. ( 2003 ). Amygdala modulation of parahippocampal and frontal regions during emotionally influenced memory storage. NeuroImage, 20, 2091 – 2099.en_US
dc.identifier.citedreferenceKlorman, R., Weerts, T. C., Hastings, J. E., Melamed, B. G., & Lang, P. J. ( 1974 ). Psychometric description of some specific‐fear questionnaires. Behavior Therapy, 5, 401 – 409.en_US
dc.identifier.citedreferenceLaBar, K. S., & Cabeza, R. ( 2006 ). Cognitive neuroscience of emotional memory. Nature Reviews Neuroscience, 7, 54 – 64.en_US
dc.identifier.citedreferenceLang, P. J., & Bradley, M. M. ( 2010 ). Emotion and the motivational brain. Biological Psychology, 84, 437 – 450.en_US
dc.identifier.citedreferenceLanteaume, L., Khalfa, S., Regis, J., Marquis, P., Chauvel, P., & Bartolomei, F. ( 2007 ). Emotion induction after direct intracerebral stimulations of human amygdala. Cerebral Cortex, 17, 1307 – 1313.en_US
dc.identifier.citedreferenceLedowski, T., Paech, M. J., Storm, H., Jones, R., & Schug, S. A. ( 2006 ). Skin conductance monitoring compared with bispectral index (R) monitoring to assess emergence from general anaesthesia using sevoflurane and remifentanil. British Journal of Anaesthesia, 97, 187 – 191.en_US
dc.identifier.citedreferenceLieberman, M. D., & Cunningham, W. A. ( 2009 ). Type I and Type II error concerns in fMRI research: Re‐balancing the scale. Social Cognitive and Affective Neuroscience, 4, 423 – 428.en_US
dc.identifier.citedreferenceMacmillan, N. A., & Creelman, C. D. ( 2005 ). Detection theory: A user's guide ( (2nd ed) ). Mahwah, NJ: Lawrence Erlbaum Associates Inc.en_US
dc.identifier.citedreferenceMaldjian, J. A., Laurienti, P. J., Kraft, R. A., & Burdette, J. H. ( 2003 ). An automated method for neuroanatomic and cytoarchitectonic atlas‐based interrogation of fMRI data sets. NeuroImage, 19, 1233 – 1239.en_US
dc.identifier.citedreferenceMcGaugh, J. L. ( 2004 ). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1 – 28.en_US
dc.identifier.citedreferenceMichelgard, A., Appel, L., Pissiota, A., Frans, O., Langstrom, B., Bergstrom, M., & Fredrikson, M. ( 2007 ). Symptom provocation in specific phobia affects the substance P neurokinin‐1 receptor system. Biological Psychiatry, 61, 1002 – 1006.en_US
dc.identifier.citedreferenceMuhlberger, A., Wiedemann, G., Herrmann, M. J., & Pauli, P. ( 2006 ). Phylo‐ and ontogenetic fears and the expectation of danger: Differences between spider‐ and flight‐phobic subjects in cognitive and physiological responses to disorder‐specific stimuli. Journal of Abnormal Psychology, 115, 580 – 589.en_US
dc.identifier.citedreferenceMuthén, L. K., & Muthén, B. O. ( 2004 ). Mplus user's guide ( 4th ed. ). Los Angeles, CA: Muthén & Muthén.en_US
dc.identifier.citedreferencePissiota, A., Frans, O., Michelgard, A., Appel, L., Langstrom, B., Flaten, M. A., & Fredrickson, M. ( 2003 ). Amygdala and anterior cingulate cortex activation during affective startle modulation: A PET study of fear. European Journal of Neuroscience, 18, 1325 – 1331.en_US
dc.identifier.citedreferenceReinecke, A., Rinck, M., & Becker, E. S. ( 2008 ). How preferential is the preferential encoding of threatening stimuli? Working memory biases in specific anxiety and the attentional blink. Journal of Anxiety Disorders, 22, 655 – 670.en_US
dc.identifier.citedreferenceRichardson, M. P., Strange, B. A., & Dolan, R. J. ( 2004 ). Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nature Neuroscience, 7, 278 – 285.en_US
dc.identifier.citedreferenceShrout, P. E., & Bolger, N. ( 2002 ). Mediation in experimental and nonexperimental studies: New procedures and recommendations. Psychological Methods, 7, 422 – 445.en_US
dc.identifier.citedreferenceSterpenich, V., D'Argembeau, A., Desseilles, M., Balteau, E., Albouy, G., Vandewalle, G., … Maquet, P. ( 2006 ). The locus ceruleus is involved in the successful retrieval of emotional memories in humans. Journal of Neuroscience, 26, 7416 – 7423.en_US
dc.identifier.citedreferenceTalairach, J., & Tournoux, P. ( 1988 ). Co‐planar stereotactic atlas of the human brain. Stuttgart, Germany: Georg Thieme Verlag.en_US
dc.identifier.citedreferenceWais, P. E., Wixted, J. T., Hopkins, R. O., & Squire, L. R. ( 2006 ). The hippocampus supports both the recollection and the familiarity components of recognition memory. Neuron, 49, 459 – 466.en_US
dc.identifier.citedreferenceWinters, B. D., Saksida, L. M., & Bussey, T. J. ( 2008 ). Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval. Neuroscience and Biobehavioral Reviews, 32, 1055 – 1070.en_US
dc.identifier.citedreferenceZola‐Morgan, S., Squire, L. R., Amaral, D. G., & Suzuki, W. A. ( 1989 ). Lesions of perirhinal and parahippocampal gyrus that spare the amygdala and hippocampal formation produce severe memory impairment. Journal of Neuroscience, 9, 4355 – 4370.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1469-8986.2011.01231.x.pdf
Size:
651.1KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.