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Development of a brain metastatic canine prostate cancer cell line

dc.contributor.authorThudi, Nanda K.en_US
dc.contributor.authorShu, Sherry T.en_US
dc.contributor.authorMartin, Chelsea K.en_US
dc.contributor.authorLanigan, Lisa G.en_US
dc.contributor.authorNadella, Murali V.P.en_US
dc.contributor.authorVan Bokhoven, Adrieen_US
dc.contributor.authorWerbeck, Jillian L.en_US
dc.contributor.authorSimmons, Jessica K.en_US
dc.contributor.authorMurahari, Sridharen_US
dc.contributor.authorKisseberth, William C.en_US
dc.contributor.authorBreen, Matthewen_US
dc.contributor.authorWilliams, Christinaen_US
dc.contributor.authorChen, Ching‐shihen_US
dc.contributor.authorMcCauley, Laurie K.en_US
dc.contributor.authorKeller, Evan T.en_US
dc.contributor.authorRosol, Thomas J.en_US
dc.date.accessioned2011-11-10T15:35:58Z
dc.date.available2012-11-02T18:56:45Zen_US
dc.date.issued2011-09en_US
dc.identifier.citationThudi, Nanda K.; Shu, Sherry T.; Martin, Chelsea K.; Lanigan, Lisa G.; Nadella, Murali V.P.; Van Bokhoven, Adrie; Werbeck, Jillian L.; Simmons, Jessica K.; Murahari, Sridhar; Kisseberth, William C.; Breen, Matthew; Williams, Christina; Chen, Ching‐shih ; McCauley, Laurie K.; Keller, Evan T.; Rosol, Thomas J. (2011). "Development of a brain metastatic canine prostate cancer cell line." The Prostate 71(12): 1251-1263. <http://hdl.handle.net/2027.42/87007>en_US
dc.identifier.issn0270-4137en_US
dc.identifier.issn1097-0045en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/87007
dc.description.abstractBACKGROUND Prostate cancer in men has a high mortality and morbidity due to metastatic disease. The pathobiology of prostate cancer metastasis is not well understood and cell lines and animal models that recapitulate the complex nature of the disease are needed. Therefore, the goal of the study was to establish and characterize a new prostate cancer line derived from a dog with spontaneous prostate cancer. METHODS A new cell line (Leo) was derived from a dog with spontaneous prostate cancer. Immunohistochemistry and PCR were used to characterize the primary prostate cancer and xenografts in nude mice. Subcutaneous tumor growth and metastases in nude mice were evaluated by bioluminescent imaging, radiography and histopathology. In vitro chemosensitivity of Leo cells to therapeutic agents was measured. RESULTS Leo cells expressed the secretory epithelial cytokeratins (CK)8, 18, and ductal cell marker, CK7. The cell line grew in vitro (over 75 passages) and was tumorigenic in the subcutis of nude mice. Following intracardiac injection, Leo cells metastasized to the brain, spinal cord, bone, and adrenal gland. The incidence of metastases was greatest to the central nervous system (80%) with a lower incidence to bone (20%) and the adrenal glands (16%). In vitro chemosensitivity assays demonstrated that Leo cells were sensitive to Velcade and an HDAC‐42 inhibitor with IC 50 concentrations of 1.9 nm and 0.95 µm, respectively. CONCLUSION The new prostate cancer cell line (Leo) will be a valuable model to investigate the mechanisms of the brain and bone metastases. Prostate 71:1251–1263, 2011. © 2011 Wiley‐Liss, Inc.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherProstate Canceren_US
dc.subject.otherBrain Metastasisen_US
dc.subject.otherSpinal Cord Metastasisen_US
dc.subject.otherDogen_US
dc.subject.otherCanineen_US
dc.subject.otherBone Metastasisen_US
dc.titleDevelopment of a brain metastatic canine prostate cancer cell lineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDepartment of Radiation Oncology, University of Alabama, Birmingham, Alabamaen_US
dc.contributor.affiliationotherDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohioen_US
dc.contributor.affiliationotherDepartment of Pathology, University of Colorado Health Sciences Center, Aurora, Coloradoen_US
dc.contributor.affiliationotherDepartment of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohioen_US
dc.contributor.affiliationotherDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolinaen_US
dc.contributor.affiliationotherDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohioen_US
dc.contributor.affiliationother1925 Coffey Road, Columbus, OH 43210.en_US
dc.identifier.pmid21321976en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/87007/1/21341_ftp.pdf
dc.identifier.doi10.1002/pros.21341en_US
dc.identifier.sourceThe Prostateen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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