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Peripherally induced human regulatory T cells uncouple Kv1.3 activation from TCR‐associated signaling

dc.contributor.authorReneer, Mary C.en_US
dc.contributor.authorEstes, Daniel Josephen_US
dc.contributor.authorVélez‐ortega, Alejandra C.en_US
dc.contributor.authorNorris, Andreaen_US
dc.contributor.authorMayer, Michaelen_US
dc.contributor.authorMarti, Francescen_US
dc.date.accessioned2011-11-10T15:39:49Z
dc.date.available2013-01-02T16:32:47Zen_US
dc.date.issued2011-11en_US
dc.identifier.citationReneer, Mary C.; Estes, Daniel J.; Vélez‐ortega, Alejandra C. ; Norris, Andrea; Mayer, Michael; Marti, Francesc (2011). "Peripherally induced human regulatory T cells uncouple Kv1.3 activation from TCRâ associated signaling." European Journal of Immunology 41(11): 3170-3175. <http://hdl.handle.net/2027.42/87163>en_US
dc.identifier.issn0014-2980en_US
dc.identifier.issn1521-4141en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/87163
dc.description.abstractPeripherally induced Tregs (iTregs) are being recognized as a functional and physiologically relevant T‐cell subset. Understanding the molecular basis of their development is a necessary step before the therapeutic potential of iTreg manipulation can be exploited. In this study, we report that the differentiation of primary human T cells to suppressor iTregs involves the relocation of key proximal TCR signaling elements to the highly active IL‐2‐Receptor (IL‐2‐R) pathway. In addition to the recruitment of lymphocyte‐specific protein tyrosine kinase (Lck) to the IL‐2‐R complex, we identified the dissociation of the voltage‐gated K + channel Kv1.3 from the TCR pathway and its functional coupling to the IL‐2‐R. The regulatory switch of Kv1.3 activity in iTregs may constitute an important contributing factor in the signaling rewiring associated with the development of peripheral human iTregs and sheds new light upon the reciprocal crosstalk between the TCR and the IL‐2‐R pathways.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherHuman Tregen_US
dc.subject.otherIL‐2 Receptor Pathwayen_US
dc.subject.otherKv1.3 Ion Channelen_US
dc.subject.otherPeripheral T‐Cell Differentiationen_US
dc.subject.otherT‐Cell Signalingen_US
dc.titlePeripherally induced human regulatory T cells uncouple Kv1.3 activation from TCR‐associated signalingen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biomedical Engineering and Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, USAen_US
dc.contributor.affiliationotherDepartment of Microbiology, Immunology and Molecular Genetics. University of Kentucky College of Medicine, 800 Rose Street – Chandler Medical Center, MN‐458, Lexington, KY 40536‐0298, USA Fax: +1‐859‐257‐8994en_US
dc.identifier.pmid21834013en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/87163/1/eji_201141492_sm_SupplInfo.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/87163/2/3170_ftp.pdf
dc.identifier.doi10.1002/eji.201141492en_US
dc.identifier.sourceEuropean Journal of Immunologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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