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Enhancement of cancer chemotherapy in vitro by intense ultrawideband electric field pulses

dc.contributor.authorJordan, David W.en_US
dc.contributor.authorUhler, Michael D.en_US
dc.contributor.authorGilgenbach, Ronald M.en_US
dc.contributor.authorLau, Y. Y.en_US
dc.date.accessioned2011-11-15T16:01:52Z
dc.date.available2011-11-15T16:01:52Z
dc.date.issued2006-05-01en_US
dc.identifier.citationJordan, David W.; Uhler, Michael D.; Gilgenbach, Ronald M.; Lau, Y. Y. (2006). "Enhancement of cancer chemotherapy in vitro by intense ultrawideband electric field pulses." Journal of Applied Physics 99(9): 094701-094701-4. <http://hdl.handle.net/2027.42/87477>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/87477
dc.description.abstractExperiments have been performed to enhance the Jurkat cell-killing effects of the cancer chemotherapy agent bleomycin using electric field pulses of 50–200 kV/cm50–200kV∕cm peak electric field strength, ∼ 150 ns∼150ns duration, and nanosecond rise time. Dramatic increases in cell killing (factors of ∼ 1000∼1000) were observed with a low dose of bleomycin after treatment with trains of ten or more pulses at all electric field strengths tested, compared to pulse-only or drug-only treatments. Cell death occurred within 24 h24h for treated cells, with some evidence of membrane phosphatidylserine externalization at 6 h6h postexposure but no significant increase in caspase activity, indicating that the primary mode of cell death was not caspase-mediated apoptosis.en_US
dc.publisherThe American Institute of Physicsen_US
dc.rights© The American Institute of Physicsen_US
dc.titleEnhancement of cancer chemotherapy in vitro by intense ultrawideband electric field pulsesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNuclear Engineering and Radiological Sciences Department, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMolecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumNuclear Engineering and Radiological Sciences Department, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/87477/2/094701_1.pdf
dc.identifier.doi10.1063/1.2194115en_US
dc.identifier.sourceJournal of Applied Physicsen_US
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dc.owningcollnamePhysics, Department of


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