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Microfluidic model of bubble lodging in microvessel bifurcations

dc.contributor.authorCalderón, Andrés J.en_US
dc.contributor.authorHeo, Yun Seoken_US
dc.contributor.authorHuh, Dongeunen_US
dc.contributor.authorFutai, Nobuyukien_US
dc.contributor.authorTakayama, Shuichien_US
dc.contributor.authorFowlkes, J. Brianen_US
dc.contributor.authorBull, Joseph L.en_US
dc.date.accessioned2011-11-15T16:08:59Z
dc.date.available2011-11-15T16:08:59Z
dc.date.issued2006-12-11en_US
dc.identifier.citationCalderón, Andrés J.; Heo, Yun Seok; Huh, Dongeun; Futai, Nobuyuki; Takayama, Shuichi; Fowlkes, J. Brian; Bull, Joseph L. (2006). "Microfluidic model of bubble lodging in microvessel bifurcations." Applied Physics Letters 89(24): 244103-244103-3. <http://hdl.handle.net/2027.42/87802>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/87802
dc.description.abstractThe lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm20μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.en_US
dc.publisherThe American Institute of Physicsen_US
dc.rights© The American Institute of Physicsen_US
dc.titleMicrofluidic model of bubble lodging in microvessel bifurcationsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Radiology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/87802/2/244103_1.pdf
dc.identifier.doi10.1063/1.2402898en_US
dc.identifier.sourceApplied Physics Lettersen_US
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dc.owningcollnamePhysics, Department of


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