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Lack of IL‐7 and IL‐15 signaling affects interferon‐γ production by, more than survival of, small intestinal intraepithelial memory CD8 + T cells

dc.contributor.authorIsakov, Dmitryen_US
dc.contributor.authorDzutsev, Amiranen_US
dc.contributor.authorBerzofsky, Jay A.en_US
dc.contributor.authorBelyakov, Igor M.en_US
dc.date.accessioned2011-12-05T18:33:45Z
dc.date.available2013-02-01T20:26:18Zen_US
dc.date.issued2011-12en_US
dc.identifier.citationIsakov, Dmitry; Dzutsev, Amiran; Berzofsky, Jay A.; Belyakov, Igor M. (2011). "Lack of IL‐7 and IL‐15 signaling affects interferon‐γ production by, more than survival of, small intestinal intraepithelial memory CD8 + T cells." European Journal of Immunology 41(12): 3513-3528. <http://hdl.handle.net/2027.42/88067>en_US
dc.identifier.issn0014-2980en_US
dc.identifier.issn1521-4141en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/88067
dc.description.abstractSurvival of antigen‐specific CD8 + T cells in peripheral lymphoid organs during viral infection is known to be dependent predominantly on IL‐7 and IL‐15. However, little is known about a possible influence of tissue environmental factors on this process. To address this question, we studied survival of memory antigen‐specific CD8 + T cells in the small intestine. Here, we show that 2 months after vaccinia virus infection, B8R 20–27 /H2‐K b tetramer + CD8 + T cells in the small intestinal intraepithelial (SI‐IEL) layer are found in mice deficient in IL‐15 expression. Moreover, SI‐IEL and lamina propria lymphocytes do not express the receptor for IL‐7 (IL‐7Rα/CD127). In addition, after in vitro stimulation with B8R 20–27 peptide, SI‐IEL cells do not produce high amounts of IFN‐γ neither at 5 days nor at 2 months postinfection (p.i.). Importantly, the lack of IL‐15 was found to shape the functional activity of antigen‐specific CD8 + T cells, by narrowing the CTL avidity repertoire. Taken together, these results reveal that survival factors, as well as the functional activity, of antigen‐specific CD8 + T cells in the SI‐IEL compartments may markedly differ from their counterparts in peripheral lymphoid tissues.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.titleLack of IL‐7 and IL‐15 signaling affects interferon‐γ production by, more than survival of, small intestinal intraepithelial memory CD8 + T cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, School of Medicine, 109 Zina Pitcher Place, BSRB, Room 4039, Ann Arbor, MI 48109, USA Fax: +1‐734‐615‐2506en_US
dc.contributor.affiliationotherMolecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USAen_US
dc.identifier.pmid21928282en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/88067/1/3513_ftp.pdf
dc.identifier.doi10.1002/eji.201141453en_US
dc.identifier.sourceEuropean Journal of Immunologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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