Synthesis of N‐{N‐[4‐(4‐{ N ‐[ 11 C]methylamino}phenyl)butyryl]‐L‐prolyl}pyrrolidine: A potential radiotracer for prolyl endopeptidase
dc.contributor.author | Van Dort, Marcian E. | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Mangner, Thomas J. | en_US |
dc.date.accessioned | 2012-03-16T15:58:24Z | |
dc.date.available | 2012-03-16T15:58:24Z | |
dc.date.issued | 1994-05 | en_US |
dc.identifier.citation | Van Dort, Marcian E.; Kilbourn, Michael R.; Mangner, Thomas J. (1994). "Synthesis of N‐{N‐[4‐(4‐{ N ‐[ 11 C]methylamino}phenyl)butyryl]‐L‐prolyl}pyrrolidine: A potential radiotracer for prolyl endopeptidase." Journal of Labelled Compounds and Radiopharmaceuticals 34(5): 447-452. <http://hdl.handle.net/2027.42/90277> | en_US |
dc.identifier.issn | 0362-4803 | en_US |
dc.identifier.issn | 1099-1344 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/90277 | |
dc.description.abstract | The synthesis of the 4‐[ 11 C]methylamino derivative of N‐{N‐[4‐(4‐Aminophenyl)butyryl]‐L‐prolyl}pyrrolidine (SUAM‐1221), is described as a potential marker for prolyl endopeptidase for in vivo positron emission tomography studies. Direct methylation of the 4‐amino derivative of SUAM‐1221 ( 1 ) with methyl iodide provided a mixture of the 4‐monomethyl ( 2 ) and 4‐dimethylamino ( 3 ) derivatives which were separated by chromatography. Methylation of 1 with [ 11 C]methyl iodide provided the 4‐[ 11 C]methylamino derivative of SUAM‐1221, ([ 11 C] 2 ), in 18–30% decay corrected radiochemical yield after HPLC purification, with a specific activity > 1700 Ci/mmol and a 40 minute synthesis time from end of bombardment. | en_US |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Prolyl Endopeptidase Inhibitor | en_US |
dc.subject.other | PET | en_US |
dc.subject.other | Carbon‐11 | en_US |
dc.subject.other | SUAM‐1221 | en_US |
dc.title | Synthesis of N‐{N‐[4‐(4‐{ N ‐[ 11 C]methylamino}phenyl)butyryl]‐L‐prolyl}pyrrolidine: A potential radiotracer for prolyl endopeptidase | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine University of Michigan Medical School, Ann Arbor, Ml 48109‐0552, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/90277/1/2580340507_ftp.pdf | |
dc.identifier.doi | 10.1002/jlcr.2580340507 | en_US |
dc.identifier.source | Journal of Labelled Compounds and Radiopharmaceuticals | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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