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Reduced insular γ‐aminobutyric acid in fibromyalgia

dc.contributor.authorFoerster, Bradley R.en_US
dc.contributor.authorPetrou, Myriaen_US
dc.contributor.authorEdden, Richard A. E.en_US
dc.contributor.authorSundgren, Pia C.en_US
dc.contributor.authorSchmidt‐wilcke, Tobiasen_US
dc.contributor.authorLowe, Suzan E.en_US
dc.contributor.authorHarte, Steven E.en_US
dc.contributor.authorClauw, Daniel J.en_US
dc.contributor.authorHarris, Richard E.en_US
dc.date.accessioned2012-03-16T15:58:42Z
dc.date.available2013-04-01T14:17:24Zen_US
dc.date.issued2012-02en_US
dc.identifier.citationFoerster, Bradley R.; Petrou, Myria; Edden, Richard A. E.; Sundgren, Pia C.; Schmidt‐wilcke, Tobias ; Lowe, Suzan E.; Harte, Steven E.; Clauw, Daniel J.; Harris, Richard E. (2012). "Reduced insular γâ aminobutyric acid in fibromyalgia." Arthritis & Rheumatism 64(2): 579-583. <http://hdl.handle.net/2027.42/90292>en_US
dc.identifier.issn0004-3591en_US
dc.identifier.issn1529-0131en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/90292
dc.description.abstractObjective Recent scientific findings have reinvigorated interest in examining the role of γ‐aminobutyric acid (GABA), the major inhibitory central nervous system neurotransmitter, in chronic pain conditions. Decreased inhibitory neurotransmission is a proposed mechanism in the pathophysiology of chronic pain syndromes such as fibromyalgia (FM). The purpose of this study was to test the hypothesis that decreased levels of insular and anterior cingulate GABA would be present in FM patients, and that the concentration of this neurotransmitter would be correlated with pressure–pain thresholds. Methods Sixteen FM patients and 17 age‐ and sex‐matched healthy controls underwent pressure–pain testing and a 3T proton magnetic resonance spectroscopy session in which the right anterior insula, right posterior insula, anterior cingulate, and occipital cortex were examined in subjects at rest. Results GABA levels in the right anterior insula were significantly lower in FM patients compared with healthy controls (mean ± SD 1.17 ± 0.24 arbitrary institutional units versus 1.42 ± 0.32 arbitrary institutional units; P = 0.016). There was a trend toward increased GABA levels in the anterior cingulate of FM patients compared with healthy controls ( P = 0.06). No significant differences between groups were detected in the posterior insula or occipital cortex ( P > 0.05 for all comparisons). Within the right posterior insula, higher levels of GABA were positively correlated with pressure–pain thresholds in the FM patients (Spearman's rho = 0.63; P = 0.02). Conclusion Diminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes.en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.titleReduced insular γ‐aminobutyric acid in fibromyalgiaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan and Ann Arbor VA Healthcare System, Ann Arbor, Michigan, and Johns Hopkins University, Baltimore, Marylanden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, and Johns Hopkins University, Baltimore, Marylanden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arboren_US
dc.contributor.affiliationumDepartment of Radiology, University of Michigan, 1500 East Medical Center Drive UH B2 A205A, Ann Arbor, MI 48109‐5030en_US
dc.contributor.affiliationotherLund University, Lund, Swedenen_US
dc.contributor.affiliationotherJohns Hopkins University and Kennedy Krieger Institute, Baltimore, Marylanden_US
dc.identifier.pmid21913179en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/90292/1/33339_ftp.pdf
dc.identifier.doi10.1002/art.33339en_US
dc.identifier.sourceArthritis & Rheumatismen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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