Tritium labeling of potential lipophilic myelin probes
dc.contributor.author | Ehrenkaufer, Richard E. | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.contributor.author | Bieszki, J. | en_US |
dc.contributor.author | Frey, Kirk A. | en_US |
dc.contributor.author | Hays, S. | en_US |
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.date.accessioned | 2012-03-16T16:01:38Z | |
dc.date.available | 2012-03-16T16:01:38Z | |
dc.date.issued | 1984-01 | en_US |
dc.identifier.citation | Ehrenkaufer, R. L. E.; Agranoff, B. W.; Bieszki, J.; Frey, K.; Hays, S.; Jewett, D. (1984). "Tritium labeling of potential lipophilic myelin probes." Journal of Labelled Compounds and Radiopharmaceuticals 21(1): 87-95. <http://hdl.handle.net/2027.42/90398> | en_US |
dc.identifier.issn | 0362-4803 | en_US |
dc.identifier.issn | 1099-1344 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/90398 | |
dc.description.abstract | Two potential lipophilic myelin imaging agents (1,1,2,2‐tetrafluoro‐1,2‐diphenylethane and 1‐fluoroadamantane) were tritium labeled. The most effective method employed the microwave discharge activation of tritium gas technique and resulted in specific activities of 177 mCi/mmol for 1,1,2,2‐tetrafluoro‐1,2‐diphenylethane and 593 mCi/mmol for 1‐fluoroadamantane. Using this tritiation method significant amounts of tritium‐for‐fluorine substitution was also observed in the labeling of 1‐fluoroadamatane, resulting in nearly equivalent amounts of tritiated adamantane and fluoroadamantane. | en_US |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Microwave Discharge Labeling | en_US |
dc.subject.other | Tritium Labeling | en_US |
dc.subject.other | Positron Emission Tomography | en_US |
dc.subject.other | Myelin | en_US |
dc.subject.other | Exchange Labeling | en_US |
dc.title | Tritium labeling of potential lipophilic myelin probes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Hospitals, Division of Nuclear Medicine, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Department of Biological Chemistry, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Neuroscience Laboratory, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Department of Anesthesiology, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Warner Lambert/Parke‐Davis Pharmaceutical Division, Ann Arbor, Michigan 48105 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/90398/1/2580210110_ftp.pdf | |
dc.identifier.doi | 10.1002/jlcr.2580210110 | en_US |
dc.identifier.source | Journal of Labelled Compounds and Radiopharmaceuticals | en_US |
dc.identifier.citedreference | Young I. R., Hall A. S., Palus C. A., et. al. ‐ Lancet 14: 1063 ( 1981 ) | en_US |
dc.identifier.citedreference | Doyle F. H., Pennock J. M., Orr J. S. et. al. ‐ Lancet 11: 53 ( 1981 ) | en_US |
dc.identifier.citedreference | RE unpublished results. The MDA labeling of toslyl leucyl chloromethylketone (TLCK) resulted in a major product which was tentatively identified as 3 H‐TLMK (tosyl leucyl methyl ketone). | en_US |
dc.identifier.citedreference | Gordan B. E., Peng C. T., Erwin W. R. and Lemmon R. M. ‐ Int. J. Appl. Radiat. Isot. 33: 715 ( 1982 ) | en_US |
dc.identifier.citedreference | Ehrenkaufer R. L. E., Hembree W. C., and Lieberman S., Wolf A. P. ‐ J. Amer. Chem. Soc. 99: 5005 ( 1977 ) | en_US |
dc.identifier.citedreference | Leo A., Hansch C., Elkins D. ‐ Chem. Rev. 71: 525 ( 1971 ) | en_US |
dc.identifier.citedreference | Ehrenkaufer R. L. E., Wolf A. P., Hembree W. C. ‐ J. Labelled Comp. Radiopharm. 14: 271 ( 1978 ) | en_US |
dc.identifier.citedreference | Hembree W. C., Ehrenkaufer R. L. E., Lieberman A. and Wolf A. P. ‐ J. Biol. Chem. 248: 5532 ( 1973 ) | en_US |
dc.identifier.citedreference | Carbon‐Fluorine Compounds. Chemistry Biochemistry And Biological Activities. A Ciba Foundation Symposium ‐ Associated Scientific Pub. Amsterdam, 1972. | en_US |
dc.identifier.citedreference | Casella V., Ido T., Wolf A. P. ‐ J. Nucl. Med. 21: 750 ( 1980 ) | en_US |
dc.identifier.citedreference | Rozen S., Brand M. ‐ J. Org. Chem. 46: 733 ( 1981 ) | en_US |
dc.identifier.citedreference | Alker D., Barton D. H. R., Hesse, R. H., et al ‐ Nouv. J. Chim. 4: 239 ( 1980 ) | en_US |
dc.identifier.citedreference | Guzikowski A. P. ‐Doctoral Thesis“ The Addition of Molecular Fluorine to Tolanes and Stilbenes ”(May 1980 ),University of Massachusetts, and R. R. MacGregor, J. Fowler,Brookhaven National Laboratory (personal communication) | en_US |
dc.identifier.citedreference | Peng C. T., Gordan B. E., Erwin W. R. and Lemmon R. M. ‐ Int. J. Appl. Radiat. Isot. 33: 419 ( 1982 ) | en_US |
dc.identifier.citedreference | Dischino D. D., Wittmer S. L., Raichle M. E. and Welch M. J. ‐ J. Labeled Comp. Radiopharm. 18: 238 ( 1981 )abst. | en_US |
dc.identifier.citedreference | Dischino D. D., Kilbourn M. R., Raichle M. E. and Welch M. J. ‐ J. Nucl. Med. 23: P‐23 ( 1982 )abst. | en_US |
dc.identifier.citedreference | Frey K. A., Wieland D. M., Brown L. E., Rogers W. L. and Agranoff B. W. ‐ Annals of Neurology 10: 214 ( 1981 ) | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.