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Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study

dc.contributor.authorGiardino, Nicholas D.
dc.contributor.authorCurtis, Jeffrey L.
dc.contributor.authorAndrei, Adin-Cristian
dc.contributor.authorFan, Vincent S.
dc.contributor.authorBenditt, Joshua
dc.contributor.authorLyubkin, Mark
dc.contributor.authorNaunheim, Keith
dc.contributor.authorCriner, Gerard
dc.contributor.authorMake, Barry
dc.contributor.authorWise, Robert
dc.contributor.authorMurray, Susan
dc.contributor.authorFishman, Alfred
dc.contributor.authorSciurba, Frank
dc.contributor.authorLiberzon, Israel
dc.contributor.authorMartinez, Fernando J.
dc.date.accessioned2012-07-01T05:21:55Z
dc.date.available2012-07-01T05:21:55Z
dc.date.issued2010
dc.identifier.citationRespiratory Research 2010 vol. 11 no.1 pp.1-11. <http://hdl.handle.net/2027.42/91944>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/91944
dc.description.abstractBackground: Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with selfreported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea. Methods: Data from 1828 patients with moderate to severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), collected prior to rehabilitation and randomization, were used in linear regression models to test the association between anxiety symptoms, measured by the Spielberger State Trait Anxiety Inventory (STAI) and: (a) six-minute walk distance test (6 MWD), (b) cycle ergometry peak workload, (c) St. Georges Respiratory Questionnaire (SRGQ), and (d) UCSD Shortness of Breath Questionnaire (SOBQ), after controlling for potential confounders including age, gender, FEV1 (% predicted), DLCO (% predicted), and the Beck Depression Inventory (BDI). Results: Anxiety was significantly associated with worse functional capacity [6 MWD (B = -0.944, p < .001), ergometry peak workload (B = -.087, p = .04)], quality of life (B = .172, p < .001) and shortness of breath (B = .180, p < .001). Regression coefficients show that a 10 point increase in anxiety score is associated with a mean decrease in 6 MWD of 9 meters, a 1 Watt decrease in peak exercise workload, and an increase of almost 2 points on both the SGRQ and SOBQ. Conclusion: In clinically stable patients with moderate to severe emphysema, anxiety is associated with worse exercise performance, quality of life and shortness of breath, after accounting for the influence of demographic and physiologic factors known to affect these outcomes.en_US
dc.language.isoen_USen_US
dc.titleAnxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional studyen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Department of Psychiatry, Department of Biostatisticsen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/91944/1/2010 RR Anxiety is associated with diminished exercise performance and quality of life in severe emphysema.pdf
dc.identifier.sourceRespiratory Researchen_US
dc.owningcollnamePublic Health, School of (SPH)


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