Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort
dc.contributor.author | Kurt, Beth A. | en_US |
dc.contributor.author | Nolan, Vikki G. | en_US |
dc.contributor.author | Ness, Kirsten K. | en_US |
dc.contributor.author | Neglia, Joseph P. | en_US |
dc.contributor.author | Tersak, Jean M. | en_US |
dc.contributor.author | Hudson, Melissa M. | en_US |
dc.contributor.author | Armstrong, Gregory T. | en_US |
dc.contributor.author | Hutchinson, Raymond J. | en_US |
dc.contributor.author | Leisenring, Wendy M. | en_US |
dc.contributor.author | Oeffinger, Kevin C. | en_US |
dc.contributor.author | Robison, Leslie L. | en_US |
dc.contributor.author | Arora, Mukta | en_US |
dc.date.accessioned | 2012-07-12T17:25:28Z | |
dc.date.available | 2013-09-03T15:38:27Z | en_US |
dc.date.issued | 2012-07-15 | en_US |
dc.identifier.citation | Kurt, Beth A.; Nolan, Vikki G.; Ness, Kirsten K.; Neglia, Joseph P.; Tersak, Jean M.; Hudson, Melissa M.; Armstrong, Gregory T.; Hutchinson, Raymond J.; Leisenring, Wendy M.; Oeffinger, Kevin C.; Robison, Leslie L.; Arora, Mukta (2012). "Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort ." Pediatric Blood & Cancer 59(1): 126-132. <http://hdl.handle.net/2027.42/92104> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/92104 | |
dc.description.abstract | Background Chronic health conditions are common among long‐term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause‐specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. Procedure The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self‐reported hospitalizations from 10,366 survivors (diagnosed 1970–1986) were compared to U.S. population rates using age‐ and sex‐stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment‐related risk factors with hospitalization were investigated. Results Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13–32) and 28.6 years of age (SD: 7.7, range: 13–51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow‐up and cancer diagnosis, with highest SIRs noted among male (SIR = 2.6, 95% CI: 2.2; 3.0) and female (SIR = 2.7, 95% CI: 2.4; 3.1) survivors aged 45–54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non‐obstetrical hospitalization. Conclusions Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment‐related complications as this population ages. Pediatr Blood Cancer 2012; 59: 126–132. © 2011 Wiley Periodicals, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Cancer Survivor | en_US |
dc.subject.other | Hospitalization | en_US |
dc.subject.other | Childhood Cancer | en_US |
dc.title | Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | Division of Pediatric Hematology, Oncology and BMT, Helen DeVos Children's Hospital, Grand Rapids, Michigan | en_US |
dc.contributor.affiliationother | Division of Epidemiology and Biostatistics, University of Memphis School of Public Health, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | University of Pittsburgh School of Medicine, Division of Pediatric Hematology/Oncology, Pittsburgh, Pennsylvania | en_US |
dc.contributor.affiliationother | Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee | en_US |
dc.contributor.affiliationother | Clinical Research and the Public Health Sciences Divisions of the Fred Hutchinson Cancer Research Center, Seattle, Washington | en_US |
dc.contributor.affiliationother | Department of Pediatrics and Medicine, Memorial Sloan‐Kettering Cancer Center, New York, New York | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Minnesota, Minneapolis, Minnesota | en_US |
dc.contributor.affiliationother | Division of Pediatric Hematology, Oncology and BMT, Helen DeVos Children's Hospital, 100 Michigan Street MC 085, Grand Rapids, MI 49503. | en_US |
dc.identifier.pmid | 22180128 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/92104/1/24017_ftp.pdf | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/92104/2/pbc_24017_sm_SupplFig1.pdf | |
dc.identifier.doi | 10.1002/pbc.24017 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.identifier.citedreference | Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long‐term survivors of childhood CNS malignancies: a report from the Childhood Cancer Survivor Study. Neuropsychology 2009; 23: 705 – 717. | en_US |
dc.identifier.citedreference | Armstrong GT, Liu Q, Yasui Y, et al. Long‐term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst 2009; 101: 946 – 958. | en_US |
dc.identifier.citedreference | Tucker MA, Meadows AT, Boice JD, et al. Leukemia after therapy with alkylating agents for childhood cancer. J Natl Cancer Inst 1987; 78: 459 – 464. | en_US |
dc.identifier.citedreference | Robison LL, Mertens AC, Boice J, et al. Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi‐institutional collaborative project. Med Pediatr Oncol 2002; 38: 229 – 239. | en_US |
dc.identifier.citedreference | Mariotto AB, Rowland JH, Yabroff KR, et al. Long‐term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev 2009; 18: 1033 – 1040. | en_US |
dc.identifier.citedreference | Ries L, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review, 1975–2004. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2004/, released 2007 to the SEER web site, based on November 2006 SEER data submission. Accessed February 1, 2008. | en_US |
dc.identifier.citedreference | Oeffinger KC, Hudson MM. Long‐term complications following childhood and adolescent cancer: foundations for providing risk‐based health care for survivors. CA Cancer J Clin 2004; 54: 208 – 236. | en_US |
dc.identifier.citedreference | Oeffinger KC, Robison LL. Childhood cancer survivors, late effects, and a new model for understanding survivorship. JAMA 2007; 297: 2762 – 2764. | en_US |
dc.identifier.citedreference | Diller L, Chow EJ, Gurney JG, et al. Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings. J Clin Oncol 2009; 27: 2339 – 2355. | en_US |
dc.identifier.citedreference | Geenen MM, Cardous‐Ubbink MC, Kremer LC, et al. Medical assessment of adverse health outcomes in long‐term survivors of childhood cancer. JAMA 2007; 297: 2705 – 2715. | en_US |
dc.identifier.citedreference | Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006; 355: 1572 – 1582. | en_US |
dc.identifier.citedreference | Oeffinger KC, Mertens AC, Hudson MM, et al. Health care of young adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Fam Med 2004; 2: 61 – 70. | en_US |
dc.identifier.citedreference | Robison LL, Armstrong GT, Boice JD, et al. The Childhood Cancer Survivor Study: a National Cancer Institute‐supported resource for outcome and intervention research. J Clin Oncol 2009; 27: 2308 – 2318. | en_US |
dc.identifier.citedreference | Neglia JP, Robison LL, Stovall M, et al. New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 2006; 98: 1528 – 1537. | en_US |
dc.identifier.citedreference | Gurney JG, Kadan‐Lottick NS, Packer RJ, et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer 2003; 97: 663 – 673. | en_US |
dc.identifier.citedreference | Bowers DC, Liu Y, Leisenring W, et al. Late‐occurring stroke among long‐term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2006; 24: 5277 – 5282. | en_US |
dc.identifier.citedreference | Anderson DM, Rennie KM, Ziegler RS, et al. Medical and neurocognitive late effects among survivors of childhood central nervous system tumors. Cancer 2001; 92: 2709 – 2719. | en_US |
dc.identifier.citedreference | Neglia JP, Friedman DL, Yasui Y, et al. Second malignant neoplasms in five‐year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 2001; 93: 618 – 629. | en_US |
dc.identifier.citedreference | Martin WG, Ristow KM, Habermann TM, et al. Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma. J Clin Oncol 2005; 23: 7614 – 7620. | en_US |
dc.identifier.citedreference | Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol 2007; 25: 43 – 49. | en_US |
dc.identifier.citedreference | Bhatia S, Yasui Y, Robison LL, et al. High risk of subsequent neoplasms continues with extended follow‐up of childhood Hodgkin's disease: report from the Late Effects Study Group. J Clin Oncol 2003; 21: 4386 – 4394. | en_US |
dc.identifier.citedreference | Aleman BM, van den Belt‐Dusebout AW, De Bruin ML, et al. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 2007; 109: 1878 – 1886. | en_US |
dc.identifier.citedreference | National Center for Health Statistics. National Hospital Discharge Survey—Annual summary. Hyattsville, MD: National Center for Health Statistics; 1992–2005. | en_US |
dc.identifier.citedreference | Breslow N, Day N. Statistical methods in cancer research. Oxford: Oxford University Press; 1987. | en_US |
dc.identifier.citedreference | Bergmann M, Byers T, Freedman D, et al. Validity of self‐reported diagnoses leading to hospitalization: A comparison of self‐reports with hospital records in a prospective study of American adults. Am J Epidemiol 1998; 147: 969 – 977. | en_US |
dc.identifier.citedreference | Johnson R, Horne B, Feltbower RG, et al. Hospital attendance patterns in long term survivors of cancer. Arch Dis Child 2004; 89: 374 – 377. | en_US |
dc.identifier.citedreference | Lustig RH, Post SR, Srivannaboon K, et al. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 2003; 88: 611 – 616. | en_US |
dc.identifier.citedreference | Lipshultz SE, Colan SD, Gelber RD, et al. Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. N Engl J Med 1991; 324: 808 – 815. | en_US |
dc.identifier.citedreference | Jankovic M, Brouwers P, Valsecchi MG, et al. Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. ISPACC. International Study Group on Psychosocial Aspects of Childhood Cancer. Lancet 1994; 344: 224 – 227. | en_US |
dc.identifier.citedreference | Garmey EG, Liu Q, Sklar CA, et al. Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol 2008; 26: 4639 – 4645. | en_US |
dc.identifier.citedreference | Packer RJ, Gurney JG, Punyko JA, et al. Long‐term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study. J Clin Oncol 2003; 21: 3255 – 3261. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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