The use of Neurotrophin Therapy in the Inner Ear to Augment Cochlear Implantation Outcomes
dc.contributor.author | Van De Water, Thomas | en_US |
dc.contributor.author | Laitman, Jeffrey T. | en_US |
dc.date.accessioned | 2012-11-07T17:04:35Z | |
dc.date.available | 2014-01-07T14:51:07Z | en_US |
dc.date.issued | 2012-11 | en_US |
dc.identifier.citation | Van De Water, Thomas; Laitman, Jeffrey T. (2012). "The use of Neurotrophin Therapy in the Inner Ear to Augment Cochlear Implantation Outcomes." The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 295(11): 1896-1908. <http://hdl.handle.net/2027.42/94260> | en_US |
dc.identifier.issn | 1932-8486 | en_US |
dc.identifier.issn | 1932-8494 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/94260 | |
dc.description.abstract | Severe to profound deafness is most often secondary to a loss of or injury to cochlear mechanosensory cells, and there is often an associated loss of the peripheral auditory neural structures, specifically the spiral ganglion neurons and peripheral auditory fibers. Cochlear implantation is currently our best hearing rehabilitation strategy for severe to profound deafness. These implants work by directly electrically stimulating the remnant auditory neural structures within the deafened cochlea. When administered to the deafened cochlea in animal models, neurotrophins, specifically brain derived neurotrophic factor and neurotrophin‐3, have been shown to dramatically improve spiral ganglion neuron survival and stimulate peripheral auditory fiber regrowth. In animal models, neurotrophins administered in combination with cochlear implantation has resulted in significant improvements in the electrophysiological and psychophysical measures of outcome. While further research must be done before these therapies can be applied clinically, neurotrophin therapies for the inner ear show great promise in enhancing CI outcomes and the treatment of hearing loss. Anat Rec, 2012. © 2012 Wiley Periodiclas, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Neurotrophin | en_US |
dc.subject.other | BDNF | en_US |
dc.subject.other | NT3 | en_US |
dc.subject.other | Cochlear Implant | en_US |
dc.title | The use of Neurotrophin Therapy in the Inner Ear to Augment Cochlear Implantation Outcomes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 1150 West Medical Center Drive, MSRB III, Room 9301, Ann Arbor, MI 48109 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/94260/1/22586_ftp.pdf | |
dc.identifier.doi | 10.1002/ar.22586 | en_US |
dc.identifier.source | The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology | en_US |
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