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Nanoscale structure of type I collagen fibrils: Quantitative measurement of D‐spacing

dc.contributor.authorErickson, Blakeen_US
dc.contributor.authorFang, Mingen_US
dc.contributor.authorWallace, Joseph M.en_US
dc.contributor.authorOrr, Bradford G.en_US
dc.contributor.authorLes, Clifford M.en_US
dc.contributor.authorBanaszak Holl, Mark M.en_US
dc.date.accessioned2013-01-03T19:36:38Z
dc.date.available2014-03-03T15:09:24Zen_US
dc.date.issued2013-01en_US
dc.identifier.citationErickson, Blake; Fang, Ming; Wallace, Joseph M.; Orr, Bradford G.; Les, Clifford M.; Banaszak Holl, Mark M. (2013). "Nanoscale structure of type I collagen fibrils: Quantitative measurement of D‐spacing." Biotechnology Journal 8(1): 117-126. <http://hdl.handle.net/2027.42/94732>en_US
dc.identifier.issn1860-6768en_US
dc.identifier.issn1860-7314en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/94732
dc.description.abstractThis article details a quantitative method to measure the D‐periodic spacing of type I collagen fibrils using atomic force microscopy coupled with analysis using a two‐dimensional fast fourier transform approach. Instrument calibration, data sampling and data analysis are discussed and comparisons of the data to the complementary methods of electron microscopy and X‐ray scattering are made. Examples of the application of this new approach to the analysis of type I collagen morphology in disease models of estrogen depletion and osteogenesis imperfecta (OI) are provided. We demonstrate that it is the D‐spacing distribution, not the D‐spacing mean, that showed statistically significant differences in estrogen depletion associated with early stage osteoporosis and OI. The ability to quantitatively characterize nanoscale morphological features of type I collagen fibrils will provide important structural information regarding type I collagen in many research areas, including tissue aging and disease, tissue engineering, and gene knockout studies. Furthermore, we also envision potential clinical applications including evaluation of tissue collagen integrity under the impact of diseases or drug treatments. The distribution of Type I collagen fibril D‐spacing provides important morphological information regarding Type I collagen in diseases such as early stages of osteoporosis and osteogenesis Imperfecta . In this article, the authors use Atomic Force Microscopy (AFM) imaging combined with two Dimensional Fast Fourier Transform (2D FFT) analysis to quantitatively assess Type I collagen fibril D‐spacing. This methodology allows imaging and characterization of Type I collagen constituted biological tissues, hydrogels, and other collagen based biomaterials.en_US
dc.publisherWILEY‐VCH Verlagen_US
dc.subject.otherCollagen Fibrilen_US
dc.subject.otherD‐Spacingen_US
dc.subject.other2D Fast Fourier Transformen_US
dc.subject.otherAtomic Force Microscopyen_US
dc.titleNanoscale structure of type I collagen fibrils: Quantitative measurement of D‐spacingen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiomedical Engineeringen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumProgram in Biophysics, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumProgram in Applied Physics, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Physics, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, MI 48109‐1055, USAen_US
dc.contributor.affiliationumDepartment of Physics, 450 Church Street, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherBiomedical Engineering, Indiana University‐Purdue University, Indianapolis, IN, USAen_US
dc.contributor.affiliationotherDepartment of Biomedical Engineering, 723 W. Michigan SL220D, Indiana University‐Purdue University Indianapolis, Indianapolis, IN 46202, USAen_US
dc.contributor.affiliationotherBone and Joint Center, Henry Ford Hospital, Detroit, MI, USAen_US
dc.contributor.affiliationotherMichigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, MI, USAen_US
dc.identifier.pmid23027700en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/94732/1/117_ftp.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/94732/2/biot_201200174_sm_suppinfo.pdf
dc.identifier.doi10.1002/biot.201200174en_US
dc.identifier.sourceBiotechnology Journalen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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