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Fetal Liver Bisphenol A Concentrations and Biotransformation Gene Expression Reveal Variable Exposure and Altered Capacity for Metabolism in Humans

dc.contributor.authorSlitt, Angela L.en_US
dc.contributor.authorHodgson, Ernesten_US
dc.date.accessioned2013-03-05T18:17:14Z
dc.date.available2014-04-02T15:08:07Zen_US
dc.date.issued2013-02en_US
dc.identifier.citationSlitt, Angela L.; Hodgson, Ernest (2013). "Fetal Liver Bisphenol A Concentrations and Biotransformation Gene Expression Reveal Variable Exposure and Altered Capacity for Metabolism in Humans." Journal of Biochemical and Molecular Toxicology 27(2): 116-123. <http://hdl.handle.net/2027.42/96672>en_US
dc.identifier.issn1095-6670en_US
dc.identifier.issn1099-0461en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/96672
dc.description.abstractWidespread exposure to the endocrine active compound, bisphenol A (BPA), is well documented in humans. A growing body of literature suggests adverse health outcomes associated with varying ranges of exposure to BPA. In the current study, we measured the internal dose of free BPA and conjugated BPA and evaluated gene expression of biotransformation enzymes specific for BPA metabolism in 50 first‐ and second‐trimester human fetal liver samples. Both free BPA and conjugated BPA concentrations varied widely, with free BPA exhibiting three times higher concentrations than conjugated BPA concentrations. As compared to gender‐matched adult liver controls, UDP‐glucuronyltransferase, sulfotransferase, and steroid sulfatase genes exhibited reduced expression whereas β‐glucuronidase mRNA expression remained unchanged in the fetal tissues. This study provides evidence that there is considerable exposure to BPA during human pregnancy and that the capacity for BPA metabolism is altered in the human fetal liver. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:116‐123, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21459en_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherLiveren_US
dc.subject.otherBiomonitoringen_US
dc.subject.otherBiotransformationen_US
dc.subject.otherBisphenol Aen_US
dc.titleFetal Liver Bisphenol A Concentrations and Biotransformation Gene Expression Reveal Variable Exposure and Altered Capacity for Metabolism in Humansen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/96672/1/jbt21459.pdf
dc.identifier.doi10.1002/jbt.21459en_US
dc.identifier.sourceJournal of Biochemical and Molecular Toxicologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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