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Head and neck squamous cell carcinoma in pregnant women

dc.contributor.authorEliassen, Anna M.en_US
dc.contributor.authorHauff, Samantha J.en_US
dc.contributor.authorTang, Alice L.en_US
dc.contributor.authorThomas, Dafydd H.en_US
dc.contributor.authorMcHugh, Jonathan B.en_US
dc.contributor.authorWalline, Heather M.en_US
dc.contributor.authorStoerker, Jayen_US
dc.contributor.authorMaxwell, Jessica H.en_US
dc.contributor.authorWorden, Francis P.en_US
dc.contributor.authorEisbruch, Avrahamen_US
dc.contributor.authorCzerwinski, Michael J.en_US
dc.contributor.authorPapagerakis, Silvana M.en_US
dc.contributor.authorChepeha, Douglas B.en_US
dc.contributor.authorBradford, Carol R.en_US
dc.contributor.authorHanauer, David A.en_US
dc.contributor.authorCarey, Thomas E.en_US
dc.contributor.authorPrince, Mark E.en_US
dc.date.accessioned2013-03-05T18:17:36Z
dc.date.available2014-05-01T14:28:10Zen_US
dc.date.issued2013-03en_US
dc.identifier.citationEliassen, Anna M.; Hauff, Samantha J.; Tang, Alice L.; Thomas, Dafydd H.; McHugh, Jonathan B.; Walline, Heather M.; Stoerker, Jay; Maxwell, Jessica H.; Worden, Francis P.; Eisbruch, Avraham; Czerwinski, Michael J.; Papagerakis, Silvana M.; Chepeha, Douglas B.; Bradford, Carol R.; Hanauer, David A.; Carey, Thomas E.; Prince, Mark E. (2013). "Head and neck squamous cell carcinoma in pregnant women ." Head & Neck 35(3): 335-342. <http://hdl.handle.net/2027.42/96700>en_US
dc.identifier.issn1043-3074en_US
dc.identifier.issn1097-0347en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/96700
dc.description.abstractBackground The aim of this study was to investigate oral cancer in pregnant women, a rare but therapeutically challenging patient subset. Methods After institutional review board approval, an EMERSE search was used to identify all women treated at the University of Michigan from 1998 to 2010 with head and neck squamous cell carcinoma (HNSCC) during pregnancy. This identified 4 patients with tongue cancer. Biomarkers and human papillomavirus (HPV) were assessed by immunohistochemistry and multiplex PCR/mass spectrometry, respectively. Results Two patients responded well to therapy and are alive more than 10 years after diagnosis; 2 patients died of disease. All tumors overexpressed EGFR and Bcl‐xL, 3 of 4 overexpressed c‐Met, both tumors that progressed overexpressed p53. All tumors were negative for HPV, p16, estrogen receptor, progesterone receptor, and HER‐2. Conclusions Biomarkers of aggressive tumors (high EGFR, c‐Met; high Bcl‐xL‐low p53) did not correlate with outcome. Additional studies are needed to determine whether perineural invasion, delay in diagnosis, and p53 overexpression are factors in poor survival. © 2012 Wiley Periodicals, Inc. Head Neck, 2013en_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherHPVen_US
dc.subject.otherOral Canceren_US
dc.subject.otherBiomarkersen_US
dc.subject.otherPregnancyen_US
dc.subject.otherRisk Factorsen_US
dc.titleHead and neck squamous cell carcinoma in pregnant womenen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Radiation Oncology, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Otolaryngology Head and Neck Surgery, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherFormer affiliation: Sequenom Center for Molecular Diagnostics, Ann Arbor and Sequenom, San Diego, CA; current affiliation: aMDx Laboratory Sciences, Farmington Hills, MI.en_US
dc.contributor.affiliationotherCurrent address: Department of Otolaryngology, University of Pittsburgh, Pittsburg, PA.en_US
dc.contributor.affiliationotherDepartment of Environmental Health Sciences and the Cancer Biology of the Program of the Program in the Biological Sciencesen_US
dc.contributor.affiliationother1500 E. Medical Center Dr., 1904 Taubman Center, Ann Arbor, MI, 49109en_US
dc.contributor.affiliationother1150 W. Medical Center Dr., 5311 Medical Science I, Ann Arbor, MI 48109en_US
dc.identifier.pmid22422571en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/96700/1/22973_ftp.pdf
dc.identifier.doi10.1002/hed.22973en_US
dc.identifier.sourceHead & Necken_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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