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Diurnal rhythms in neural activation in the mesolimbic reward system: critical role of the medial prefrontal cortex

dc.contributor.authorBaltazar, Ricardo M.en_US
dc.contributor.authorCoolen, Lique M.en_US
dc.contributor.authorWebb, Ian C.en_US
dc.date.accessioned2013-08-02T20:51:25Z
dc.date.available2014-09-02T14:12:53Zen_US
dc.date.issued2013-07en_US
dc.identifier.citationBaltazar, Ricardo M.; Coolen, Lique M.; Webb, Ian C. (2013). "Diurnal rhythms in neural activation in the mesolimbic reward system: critical role of the medial prefrontal cortex." European Journal of Neuroscience 38(2): 2319-2327. <http://hdl.handle.net/2027.42/99016>en_US
dc.identifier.issn0953-816Xen_US
dc.identifier.issn1460-9568en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/99016
dc.description.abstractPrevious evidence suggests a circadian modulation of drug‐seeking behavior and responsiveness to drugs of abuse. To identify potential mechanisms for rhythmicity in reward, a marker of neural activation (c F os) was examined across the day in the mesolimbic reward system. Rats were perfused at six times during the day [zeitgeber times ( ZT s): 2, 6, 10, 14, 18, and 22], and brains were analysed for c F os and tyrosine hydroxylase ( TH )‐immunoreactive ( IR ) cells. Rhythmic expression of c F os was observed in the nucleus accumbens ( NA c) core and shell, in the medial prefrontal cortex (m PFC ), and in TH ‐ IR and non‐ TH ‐ IR cells in the ventral tegmental area ( VTA ), with peak expression during the late night and nadirs during the late day. No significant rhythmicity was observed in the basolateral amgydala or the dentate gyrus. As the m PFC provides excitatory input to both the NA c and VTA , this region was hypothesised to be a key mediator of rhythmic neural activation in the mesolimbic system. Hence, the effects of excitotoxic m PFC lesions on diurnal rhythms in c F os immunoreactivity at previously observed peak ( ZT 18) and nadir ( ZT 10) times were examined in the NA c and VTA . m PFC lesions encompassing the prelimbic and infralimbic subregions attenuated peak c F os immunoreactivity in the NA c, eliminating the diurnal rhythm, but had no effect on VTA rhythms. These results suggest that rhythmic neural activation in the mesolimbic system may contribute to diurnal rhythms in reward‐related behaviors, and indicate that the m PFC plays a critical role in mediating rhythmic neural activation in the NA c. Previous evidence suggests a circadian modulation of drug‐seeking behavior and responsiveness to drugs of abuse. To identify potential mechanisms for rhythmicity in reward, a maker of neural activation (c F os) was examined across the day in the mesolimbic reward system.en_US
dc.publisherCRC Pressen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherCircadianen_US
dc.subject.otherRaten_US
dc.subject.otherRewarden_US
dc.subject.otherExcitotoxic Lesionen_US
dc.subject.otherC‐ F Osen_US
dc.titleDiurnal rhythms in neural activation in the mesolimbic reward system: critical role of the medial prefrontal cortexen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid23617901en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99016/1/ejn12224.pdf
dc.identifier.doi10.1111/ejn.12224en_US
dc.identifier.sourceEuropean Journal of Neuroscienceen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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