View Item 

Show simple item record

Impaired retinal vasodilator responses in prediabetes and type 2 diabetes

dc.contributor.authorLott, Mary E. J.en_US
dc.contributor.authorSlocomb, Julia E.en_US
dc.contributor.authorShivkumar, Vikramen_US
dc.contributor.authorSmith, Bruceen_US
dc.contributor.authorQuillen, Daviden_US
dc.contributor.authorGabbay, Robert A.en_US
dc.contributor.authorGardner, Thomas W.en_US
dc.contributor.authorBettermann, Kerstinen_US
dc.date.accessioned2013-09-04T17:18:41Z
dc.date.available2014-10-06T19:17:42Zen_US
dc.date.issued2013-09en_US
dc.identifier.citationLott, Mary E. J.; Slocomb, Julia E.; Shivkumar, Vikram; Smith, Bruce; Quillen, David; Gabbay, Robert A.; Gardner, Thomas W.; Bettermann, Kerstin (2013). "Impaired retinal vasodilator responses in prediabetes and type 2 diabetes." Acta Ophthalmologica 91(6): e462-e469. <http://hdl.handle.net/2027.42/99677>en_US
dc.identifier.issn1755-375Xen_US
dc.identifier.issn1755-3768en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/99677
dc.publisherBlackwell Publishing Ltden_US
dc.publisherWiley Periodicals, Inc.en_US
dc.subject.otherFlickering Light Stimulationen_US
dc.subject.otherRetinal Reactivityen_US
dc.subject.otherType 2 Diabetesen_US
dc.subject.otherVasodilationen_US
dc.subject.otherPrediabetesen_US
dc.titleImpaired retinal vasodilator responses in prediabetes and type 2 diabetesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOphthalmologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDivision of Endocrinology, Diabetes and Metabolism, Penn State Hershey Diabetes and Obesity Institute, Penn State College of Medicine, Hershey, Pennsylvania, USAen_US
dc.contributor.affiliationotherHeart and Vascular Institute, Penn State Hershey Medical Center, Hershey, Pennsylvania, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USAen_US
dc.contributor.affiliationotherDepartment of Ophthalmology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USAen_US
dc.identifier.pmid23742315en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/99677/1/aos12129.pdf
dc.identifier.doi10.1111/aos.12129en_US
dc.identifier.sourceActa Ophthalmologicaen_US
dc.identifier.citedreferenceNguyen TT, Kawasaki R, Wang JJ, Kreis AJ, Shaw J, Vilser W & Wong TY ( 2009 ): Flicker light‐induced retinal vasodilation in diabetes and diabetic retinopathy. Diabetes Care 32: 2075 – 2080.en_US
dc.identifier.citedreferenceKotliar KE, Lanzl IM, Schmidt‐Trucksass A, Sitnikova D, Ali M, Blume K, Halle M & Hanssen H ( 2011 ): Dynamic retinal vessel response to flicker in obesity: a methodological approach. Microvasc Res 81: 123 – 128.en_US
dc.identifier.citedreferenceKullo IJ, Malik AR, Santos S, Ehrsam JE & Turner ST ( 2007 ): Association of cardiovascular risk factors with microvascular and conduit artery function in hypertensive subjects. Am J Hypertens 20: 735 – 742.en_US
dc.identifier.citedreferenceLippincott MF, Carlow A, Desai A et al. ( 2008 ): Relation of endothelial function to cardiovascular risk in women with sedentary occupations and without known cardiovascular disease. Am J Cardiol 102: 348 – 352.en_US
dc.identifier.citedreferenceLott ME, Slocomb JE, Shivkumar V, Smith B, Gabbay RA, Quillen D, Gardner TW & Bettermann K ( 2012 ): Comparison of retinal vasodilator and constrictor responses in type 2 diabetes. Acta Ophthalmol 90: e434 – e441.en_US
dc.identifier.citedreferenceMandecka A, Dawczynski J, Blum M et al. ( 2007 ): Influence of flickering light on the retinal vessels in diabetic patients. Diabetes Care 30: 3048 – 3052.en_US
dc.identifier.citedreferenceMazzone T, Chait A & Plutzky J ( 2008 ): Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet 371: 1800 – 1809.en_US
dc.identifier.citedreferenceMeng YX, Ford ES, Li C, Quarshie A, Al‐Mahmoud AM, Giles W, Gibbons GH & Strayhorn G ( 2007 ): Association of C‐reactive protein with surrogate measures of insulin resistance among nondiabetic US from National Health and Nutrition Examination Survey 1999–2002. Clin Chem 53: 2152 – 2159.en_US
dc.identifier.citedreferenceMichelson G, Patzelt A & Harazny J ( 2002 ): Flickering light increases retinal blood flow. Retina 22: 336 – 343.en_US
dc.identifier.citedreferenceMilman S & Crandall JP ( 2011 ): Mechanisms of vascular complications in prediabetes. Med Clin North Am 95: 309 – 325, vii.en_US
dc.identifier.citedreferenceMuniyappa R & Quon MJ ( 2007 ): Insulin action and insulin resistance in vascular endothelium. Curr Opin Clin Nutr Metab Care 10: 523 – 530.en_US
dc.identifier.citedreferenceMuniyappa R, Lee S, Chen H & Quon MJ ( 2008 ): Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294: E15 – E26.en_US
dc.identifier.citedreferenceNagel E & Vilser W ( 2004 ): Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study. Br J Ophthalmol 88: 54 – 56.en_US
dc.identifier.citedreferenceNakanishi N, Shiraishi T & Wada M ( 2005 ): Association between C‐reactive protein and insulin resistance in a Japanese population: the Minoh Study. Intern Med 44: 542 – 547.en_US
dc.identifier.citedreferencePemp B, Garhofer G, Weigert G, Karl K, Resch H, Wolzt M & Schmetterer L ( 2009a ): Reduced retinal vessel response to flicker stimulation but not to exogenous nitric oxide in type 1 diabetes. Invest Ophthalmol Vis Sci 50: 4029 – 4032.en_US
dc.identifier.citedreferencePemp B, Weigert G, Karl K, Petzl U, Wolzt M, Schmetterer L & Garhofer G ( 2009b ): Correlation of flicker‐induced and flow‐mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers. Diabetes Care 32: 1536 – 1541.en_US
dc.identifier.citedreferencePournaras CJ, Rungger‐Brandle E, Riva CE, Hardarson SH & Stefansson E ( 2008 ): Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27: 284 – 330.en_US
dc.identifier.citedreferenceRidker PM ( 2004 ): High‐sensitivity C‐reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. Am Heart J 148: S19 – S26.en_US
dc.identifier.citedreferenceRidker PM, Rifai N, Pfeffer MA, Sacks F & Braunwald E ( 1999 ): Long‐term effects of pravastatin on plasma concentration of C‐reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation 100: 230 – 235.en_US
dc.identifier.citedreferenceSabanayagam C & Shankar A ( 2011 ): Association between plasma homocysteine and microalbuminuria in persons without hypertension, diabetes mellitus, and cardiovascular disease. Clin Exp Nephrol 15: 92 – 99.en_US
dc.identifier.citedreferenceSchmetterer L & Wolzt M ( 1999 ): Ocular blood flow and associated functional deviations in diabetic retinopathy. Diabetologia 42: 387 – 405.en_US
dc.identifier.citedreferenceSchmetterer L, Findl O, Fasching P et al. ( 1997 ): Nitric oxide and ocular blood flow in patients with IDDM. Diabetes 46: 653 – 658.en_US
dc.identifier.citedreferenceSun C, Wang JJ, Mackey DA & Wong TY ( 2009 ): Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol 54: 74 – 95.en_US
dc.identifier.citedreferenceTan KC, Chow WS, Tam SC, Ai VH, Lam CH & Lam KS ( 2002 ): Atorvastatin lowers C‐reactive protein and improves endothelium‐dependent vasodilation in type 2 diabetes mellitus. J Clin Endocrinol Metab 87: 563 – 568.en_US
dc.identifier.citedreferenceTerai N, Spoerl E, Pillunat LE & Stodtmeister R ( 2012 ): The effect of caffeine on retinal vessel diameter in young healthy subjects. Acta Ophthalmol 90: e524 – e528.en_US
dc.identifier.citedreferenceThomsen SB, Rathcke CN, Zerahn B & Vestergaard H ( 2010 ): Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL‐40 and CRP in patients with type 2 diabetes and ischemic heart disease. Cardiovasc Diabetol 9: 86.en_US
dc.identifier.citedreferenceTilma KK & Bek T ( 2012 ): Topical treatment for 1 week with latanoprost but not diclofenac reduces the diameter of dilated retinal arterioles in patients with type 1 diabetes mellitus and mild retinopathy. Acta Ophthalmol 90: 750 – 755.en_US
dc.identifier.citedreferenceToda N, Imamura T & Okamura T ( 2010 ): Alteration of nitric oxide‐mediated blood flow regulation in diabetes mellitus. Pharmacol Ther 127: 189 – 209.en_US
dc.identifier.citedreferenceVita JA, Keaney JF Jr, Larson MG et al. ( 2004 ): Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study. Circulation 110: 3604 – 3609.en_US
dc.identifier.citedreferenceWilson PW, Pencina M, Jacques P, Selhub J, D’Agostino R Sr & O’Donnell CJ ( 2008 ): C‐reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes 1: 92 – 97.en_US
dc.identifier.citedreferenceWong TY, Islam FM, Klein R, Klein BE, Cotch MF, Castro C, Sharrett AR & Shahar E ( 2006 ): Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi‐ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 47: 2341 – 2350.en_US
dc.identifier.citedreferenceWu T, Dorn JP, Donahue RP, Sempos CT & Trevisan M ( 2002 ): Associations of serum C‐reactive protein with fasting insulin, glucose, and glycosylated hemoglobin: the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 155: 65 – 71.en_US
dc.identifier.citedreferenceAmerican Diabetes Association ( 2010 ): Standards of medical care in diabetes – 2010. Diabetes Care 33 ( Suppl 1 ): S11 – S61.en_US
dc.identifier.citedreferenceAntonetti DA, Klein R & Gardner TW ( 2012 ): Diabetic retinopathy. N Engl J Med 366: 1227 – 1239.en_US
dc.identifier.citedreferenceAronson D, Bartha P, Zinder O, Kerner A, Shitman E, Markiewicz W, Brook GJ & Levy Y ( 2004 ): Association between fasting glucose and C‐reactive protein in middle‐aged subjects. Diabet Med 21: 39 – 44.en_US
dc.identifier.citedreferenceBek T, Hajari J & Jeppesen P ( 2008 ): Interaction between flicker‐induced vasodilatation and pressure autoregulation in early retinopathy of type 2 diabetes. Graefes Arch Clin Exp Ophthalmol 246: 763 – 769.en_US
dc.identifier.citedreferenceBuckley DI, Fu R, Freeman M, Rogers K & Helfand M ( 2009 ): C‐reactive protein as a risk factor for coronary heart disease: a systematic review and meta‐analyses for the U.S. Preventive Services Task Force. Ann Intern Med 151: 483 – 495.en_US
dc.identifier.citedreferenceCaballero AE ( 2005 ): Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. Arch Med Res 36: 241 – 249.en_US
dc.identifier.citedreferenceDehghan A, van Hoek M, Sijbrands EJ, Stijnen T, Hofman A & Witteman JC ( 2007 ): Risk of type 2 diabetes attributable to C‐reactive protein and other risk factors. Diabetes Care 30: 2695 – 2699.en_US
dc.identifier.citedreferenceDoi Y, Kiyohara Y, Kubo M, Ninomiya T, Wakugawa Y, Yonemoto K, Iwase M & Iida M ( 2005 ): Elevated C‐reactive protein is a predictor of the development of diabetes in a general Japanese population: the Hisayama Study. Diabetes Care 28: 2497 – 2500.en_US
dc.identifier.citedreferenceDorner GT, Garhofer G, Huemer KH, Riva CE, Wolzt M & Schmetterer L ( 2003a ): Hyperglycemia affects flicker‐induced vasodilation in the retina of healthy subjects. Vision Res 43: 1495 – 1500.en_US
dc.identifier.citedreferenceDorner GT, Garhofer G, Kiss B, Polska E, Polak K, Riva CE & Schmetterer L ( 2003b ): Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol 285: H631 – H636.en_US
dc.identifier.citedreferenceD’Souza A, Hussain M, Howarth FC, Woods NM, Bidasee K & Singh J ( 2009 ): Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart. Mol Cell Biochem 331: 89 – 116.en_US
dc.identifier.citedreferenceFesta A, Hanley AJ, Tracy RP, D’Agostino R Jr & Haffner SM ( 2003 ): Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation 108: 1822 – 1830.en_US
dc.identifier.citedreferenceFord ES, Zhao G & Li C ( 2010 ): Pre‐diabetes and the risk for cardiovascular disease: a systematic review of the evidence. J Am Coll Cardiol 55: 1310 – 1317.en_US
dc.identifier.citedreferenceGarhofer G, Zawinka C, Resch H, Kothy P, Schmetterer L & Dorner GT ( 2004 ): Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes. Br J Ophthalmol 88: 887 – 891.en_US
dc.identifier.citedreferenceGarhofer G, Bek T, Boehm AG et al. ( 2010 ): Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol 88: 717 – 722.en_US
dc.identifier.citedreferenceHaffner SM ( 2003 ): Pre‐diabetes, insulin resistance, inflammation and CVD risk. Diabetes Res Clin Pract 61 ( Suppl 1 ): S9 – S18.en_US
dc.identifier.citedreferenceHu G, Jousilahti P, Tuomilehto J, Antikainen R, Sundvall J & Salomaa V ( 2009 ): Association of serum C‐reactive protein level with sex‐specific type 2 diabetes risk: a prospective Finnish study. J Clin Endocrinol Metab 94: 2099 – 2105.en_US
dc.identifier.citedreferenceKatz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G & Quon MJ ( 2000 ): Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85: 2402 – 2410.en_US
dc.identifier.citedreferenceKifley A, Wang JJ, Cugati S, Wong TY & Mitchell P ( 2008 ): Retinal vascular caliber and the long‐term risk of diabetes and impaired fasting glucose: the Blue Mountains Eye Study. Microcirculation 15: 373 – 377.en_US
dc.identifier.citedreferenceKing DE, Mainous AG 3rd, Buchanan TA & Pearson WS ( 2003 ): C‐reactive protein and glycemic control in adults with diabetes. Diabetes Care 26: 1535 – 1539.en_US
dc.identifier.citedreferenceKlein BE, Klein R, Lee KE, Knudtson MD & Tsai MY ( 2006 ): Markers of inflammation, vascular endothelial dysfunction, and age‐related cataract. Am J Ophthalmol 141: 116 – 122.en_US
dc.identifier.citedreferenceKneser M, Kohlmann T, Pokorny J & Tost F ( 2009 ): Age related decline of microvascular regulation measured in healthy individuals by retinal dynamic vessel analysis. Med Sci Monit 15: CR436 – CR441.en_US
dc.identifier.citedreferenceKondo M, Wang L & Bill A ( 1997 ): The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats. Acta Ophthalmol Scand 75: 232 – 235.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
aos12129.pdf
Size:
252.0KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.