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- Creator:
- Hutson, Abby , Fujisaki-Manome, Ayumi, and Glassman, Ryan
- Description:
- The data herein resulted from a study documenting the characteristics of extratropical cyclones that pass through the Great Lakes Region (GLR) and how the cyclones are trending with time. All scripts used to create these data can be found in the Github repository https://github.com/abkenyon/GLStormTrends_2024. storm_track_slp_xxxx.npz - Structured numpy files containing all storm tracks identified over one cold season, regardless of whether the storm encountered the GLR, with the file name indicating the year on which the season ended. storm_composite_xxxx-xxxx.nc - NetCDF files containing one seasonal cyclone composite with different atmospheric variables. A composite is storm-centered, and covers a 20 degree square area.
- Keyword:
- Extratropical Cyclones, Climate Trends, Great Lakes Climate
- Citation to related publication:
- Hutson A, Fujisaki-Manome A, Glassman R.: Historical Trends in Cold-Season Mid-Latitude Cyclones. Geophysical Research Letters. In press..
- Discipline:
- Science
-
- Creator:
- Sosa Alfaro, Victor, Palomino, Hannah, Liu, Sophia, Lemuh Njimoh, Cybele, and Lehnert, Nicolai
- Description:
- Pharmaceutical synthesis has been a driving force behind advancements in the field of biocatalysis. In this paper, we report the further optimization of the heme protein YfeX for regio- and stereoselective carbene transfer reactions using mutagenesis to explore the role of important amino acids in the active site for catalysis. In this way, we identified YfeX variants that are efficient and selective carbene transferases towards primary and secondary amines, olefins, and indoles. Molecular Dynamic simulations reveal that mutations within the secondary coordination sphere induce distinct alterations in the conformation and electrostatic properties within the active site. These changes, in turn, affect substrate positioning both within the active site and at its entrance, which explains the distinct and sometimes surprising variations in selectivity observed experimentally between select YfeX variants. Our results show that the I230A single variant identified here is one of the most active N-H insertion catalysts known, producing >90% yields in only 1 hour (typical reaction times in the literature are 8 – 24 hours). On the other hand, the R232A variant catalyzes the C-H insertion of unprotected indole in 21% yield. The capacity to selectively act on unprotected indole offers a cost-effective, environmentally-friendly approach for late-stage functionalization of indoles and similar precursors in pharmaceuticals. In addition, YfeX is an efficient and fast biocatalyst that shows no structural degradation or heme loss during turnover, underscoring YfeX’s robustness as a viable biocatalyst for both industrial and academic applications.
- Keyword:
- Biocatalysis, Heme proteins, Carbene transfer reactions, Peroxidases , N-H insertion, Cyclopropanation, and Molecular dynamics
- Citation to related publication:
- Sosa Alfaro, Victor; Palomino, Hannah; Liu, Sophia; Lemuh Njimoh, Cybele; Lehnert, Nicolai, "Combined Experimental and Molecular Dynamics Approach Towards a Rational Design of the YfeX Biocatalyst for Enhanced Carbene Transferase Reactivity", Catalysis Science & Technology 2024, 14, DOI: 10.1039/D3CY01489D
- Discipline:
- Science
-
- Creator:
- Shin, Satbyeol and Gronewold, Andrew D.
- Description:
- - Temporal coverage: 1/1/1941 to 12/31/2020 - Spatial coverage: Entire Great Lakes basin - Output format: The original modeling outputs are provided at a 1 km/daily resolution in NetCDF format. There are two kinds of modeling outputs, which are land surface modeling outputs (LDASOUT) and hydrological modeling outputs (CHRTOUT). The author recommend using the netCDF Operators (NCO) program for data processing. For visualization and plotting, the author recommend using software like MATLAB, Python or R.
- Keyword:
- Hydrologic modeling, Overland precipitation, Air temperature, Evapotranspiration, Snow Water Equivalent, Runoff, Surface Soil moisture, St. Lawrence river, Great Lakes basin, Reanalysis data, WRF-Hydro, and ERA-5
- Discipline:
- Science
-
- Creator:
- Fahim, Abigail T
- Description:
- The purpose of this research is to compare levels of unprenylated Rab proteins in CHM-/- iPSC-RPE cells with and without compactin. Compactin is a statin that inhibits prenyl synthesis and thereby reduces prenylation overall and has an unbiased inhibitory effect on all protein prenylation. So we expect that for Rabs that are already poorly prenylated at baseline in choroideremia RPE cells, compactin will have minimal effect. However, for Rabs that are efficiently prenylated at baseline, compactin should have a much greater effect. And then we used tandem mass tag spectrometry to compare the ratio of each unprenylated Rab in compactin-treated choroideremia cells vs untreated choroideremia cells. In the spreadsheet, "F8" refers to the CHM-/- iPSC-RPE cells and "WT" refers to the isogenic control iPSC-RPE cells. In the "Proteins only" tab, column M shows the ratio of each protein in "DMSO" (untreated) choroideremia cells compared to Compactin-treated choroideremia cells. Compactin-treated control cells are also included in other columns. Untreated control cells could not be used because prenylation is so efficient in these cells, there is almost no material available after doing the in vitro prenylation assay (i.e. almost no unprenylated proteins to biotinylate). The column descriptions can be found in the sheet titled "Explanations." In addition, AAs= number of amino acids in the protein, MW= molecular weight of the protein, and pI= isoelectric point. The software is set to report abundance values only when certain criteria are met (S/N of 6, unique peptide etc). A value is NOT reported when the data for a protein fall below these criteria and the cell is instead left blank.
- Keyword:
- choroideremia, retinal pigment epithelium, prenylation, and Rab protein
- Citation to related publication:
- Raeker, M.O., Perera, N.D., Karoukis, A.J., Chen, L., Feathers, K.L., Ali, R.R., Thompson, D.A., Fahim, A.T. Reduced retinal pigment epithelial autophagy due to loss of Rab12 prenylation in a human iPSC-RPE model of choroideremia. Cells, manuscript accepted, in press.
- Discipline:
- Health Sciences and Science
-
- Creator:
- Yu, Chi-Lin
- Description:
- The study aims to describe how children worldwide progress through a sequence of theory of mind understandings in their development of insights into persons and minds. The focus is on the studies using Wellman and Liu's (2004) Theory of Mind Scale. A comprehensive search was run in PsycINFO, PsycArticles, Child Development & Adolescent Studies, Education Abstracts, Family & Society Studies Worldwide, and Social Sciences Abstracts. The dataset includes 91 studies using Wellman and Liu's (2004) Theory of Mind Scale.
- Keyword:
- meta-analysis, theory of mind, social cognitive development, culture, and conceptual sequences
- Discipline:
- Science
-
- Creator:
- Abdul Kareem, Tariq
- Description:
- The four specimens (GSI SR/YS/1, GSI SR/YS/2, GSI SR/YS/3, and GSI SR/YS/4) are identified as tail clubs that are attributed to the basal sauropod Kotasaurus yamanpalliensis. The specimens were collected by the Geological Survey of India Southern Region (GSI SR) and, in 2018, the specimens were studied as a collaboration between GSI SR and the University of Michigan Museum of Paleontology. The specimens are housed in the collections of the GSI SR (Hyderabad, India).
- Keyword:
- Paleontology, India, Sauropod, Dinosaurs, Tail club, and Jurassic
- Citation to related publication:
- Kareem, T. A., S. Chakraborty, and J. A. Wilson Mantilla. (in prep.) Sauropod tail clubs from the Kota Formation (Early to Middle Jurassic) of India and their implications for early sauropod evolution. Journal of Vertebrate Paleontology
- Discipline:
- Science
-
- Creator:
- Medwedeff, William, G (University of Michigan Earth & Environmental Science), Clark, Marin, K (University of Michigan Earth & Environmental Science), and Zekkos, Dimitrios (University of California, Berkeley)
- Description:
- The matlab code, digital elevation data, and landslide volume data here support the findings of Medwedeff et al. (2024) in JGR: Earth Surface. In this article, we study past landslides to understand how the strength of rocks and soil vary across the landscape and below the ground. We develop a matlab-based model that uses the length, width, slope angle, and thickness of landslides that have occurred in the past to estimate how strong the rock or soil was before it gave way. We improve upon previous studies by using elevation data from before and after landslides occurred to measure how thick the sliding mass was for each landslide. The thickness measurements help us understand how the strength of the ground changes as a function of depth below the surface, like for example, when rocks get weaker near the surface due to increased weathering. We apply our model to landslides that occurred during earthquakes in Greece and Nepal, and we compare the results to rock strength field data. In addition to our model code, we include in this data repository the landslide volume and elevation data for Nepal and Greece that we used to run our model for this study.
- Keyword:
- landslide, inversion, rock strength, and slope stability
- Citation to related publication:
- Medwedeff, W.G., Clark, M.K., Zekkos, D. (in review 2024) Regional Back-Analysis of Earthquake Triggered Landslide Inventories: a 2D Method for Estimating Rock Strength from Remote Sensing Data. In review in JGR Earth Surface.
- Discipline:
- Science
-
- Creator:
- Giri, Bapun, Kinsky, Nathaniel, and Diba, Kamran
- Description:
- The research that produced this data tested how sleep loss impacted the phenomena of reactivation and replay, which occurs when recently-learned information is reactivated/replayed during post-learning sleep/rest.
- Keyword:
- Hippocampus, Memory, Sleep, Sleep Deprivation, and Electrophysiology
- Citation to related publication:
- Giri, B., Kinsky, N.R., Kaya, U., Maboudi, K., Abel, T., Diba, K. (2024). Sleep loss diminishes hippocampal reactivation and replay. Nature, (2024). https://doi.org/10.1038/s41586-024-07538-2
- Discipline:
- Science
-
- Creator:
- Fu, Xun, Zhang, Bohao, Weber, Ceri J., Cooper, Kimberly L., Vasudevan, Ram, and Moore, Talia Y.
- Description:
- Tails used as inertial appendages induce body rotations of animals and robots---a phenomenon that is governed largely by the ratio of the body and tail moments of inertia. However, vertebrate tails have more degrees of freedom (e.g., number of joints, rotational axes) than most current theoretical models and robotic tails. To understand how morphology affects inertial appendage function, we developed an optimization-based approach that finds the maximally effective tail trajectory and measures error from a target trajectory. For tails of equal total length and mass, increasing the number of equal-length joints increased the complexity of maximally effective tail motions. When we optimized the relative lengths of tail bones while keeping the total tail length, mass, and number of joints the same, this optimization-based approach found that the lengths match the pattern found in the tail bones of mammals specialized for inertial maneuvering. In both experiments, adding joints enhanced the performance of the inertial appendage, but with diminishing returns, largely due to the total control effort constraint. This optimization-based simulation can compare the maximum performance of diverse inertial appendages that dynamically vary in moment of inertia in 3D space, predict inertial capabilities from skeletal data, and inform the design of robotic inertial appendages.
- Keyword:
- simulation, inertial maneuvering, caudal vertebrae, trajectory optimization, and reconfigurable appendages
- Citation to related publication:
- Xun Fu, Bohao Zhang, Ceri J. Weber, Kimberly L. Cooper, Ram Vasudevan, Talia Y. Moore. (in review) Jointed tails enhance control of three-dimensional body rotation.
- Discipline:
- Engineering and Science
-
- Creator:
- Gottesman, Ari
- Description:
- This study analyzes correlations between magnetic field data from closely-spaced pairs of ground magnetometers to observe the spatial scale of ionospheric current signatures. Correlations were mainly calculated in 7.5 minute intervals for periods of multiple days. Distributions were taken from the collection of these 7.5 minute intervals to identify the amount of time where the magnetometers were observing "similar" or "different" ionospheric signatures. The raw magnetometer data was taken from two geomagnetic storms: one taking place on 7-8 September, 2017, and the other taking place on 23-24 March, 2023. These periods were selected due to the presence of both high and low geomagnetic activity. The final distributions calculated from this analysis are available in Correlation_Distributions.csv.
- Keyword:
- Space Weather Impacts, Geomagnetically Induced Currents, and GIC
- Discipline:
- Science