Search Constraints
Number of results to display per page
View results as:
Search Results
-
- Creator:
- Hatch, Nan E.
- Description:
- Craniosynostosis is the premature fusion of cranial bones. The goal of this study was to determine if delivery of recombinant tissue nonspecific alkaline phosphatase (TNAP) could prevent or diminish the severity of craniosynostosis in a C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis or a BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis. Mice were injected with a lentivirus encoding a mineral targeted form of TNAP immediately after birth. Cranial bone fusion as well as cranial bone volume, mineral content and density were assessed by micro computed tomography. Craniofacial shape was measured with calipers., Alkaline phosphatase, alanine amino transferase (ALT) and aspartate amino transferase (AST) activity levels were measured in serum. Neonatal delivery of TNAP diminished craniosynostosis severity from 94% suture obliteration in vehicle treated mice to 67% suture obliteration in treated mice, p<0.02) and the incidence of malocclusion from 82.4% to 34.7% (p<0.03), with no effect on cranial bone in C57BL/6 FGFR2C342Y/+ mice. In contrast, treatment with TNAP improved cranial bone volume (p< 0.01), density (p< 0.01) and mineral content (p< 0.01) but had no effect on craniosynostosis or malocclusion in BALB/c FGFR2C342Y/+ mice. , These results indicate that post-natal recombinant TNAP enzyme therapy diminishes craniosynostosis severity in the C57BL/6 FGFR2C342Y/+ neonatal onset mouse model of Crouzon syndrome, and that effects of exogenous TNAP are genetic background dependent., and Included in this collection is one set of images representing the C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis, and one for the BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis
- Keyword:
- craniofacial, bone, craniosynostosis, FGFR2, TNAP, mouse model, and development
- Discipline:
- Health Sciences
2Works -
- Creator:
- Walsh, Lisa L
- Description:
- Stable isotope values of carbon (δ13C) and nitrogen (δ15N) from Virginia opossum (Didelphis virginiana) guard hairs were analyzed to evaluate the ecology and winter adaptations in opossums by Dr. Lisa L. Walsh as part of her Ph.D. thesis in the Ecology and Evolutionary Biology Department. The collection of stable isotope data took place from 2017 to 2019. Guard hair was processed at the University of Michigan and analyzed by the University of New Mexico Center for Stable Isotopes (UNM-CSI, USA). Captive and wild opossums were evaluated for evidence of biannual or incomplete biannual molting, a mammalian adaptation to harsh winters. Results suggest opossums do not exhibit either winter molting strategy and that guard hairs capture the opossum’s lifetime diet (Walsh and Tucker 2021). The stable isotope values were used to test the hypothesis that a Type A generalist’s niche is positively correlated with habitat heterogeneity and to evaluate which climate variables best explained isotope values. There was a positive correlation between isotopic niche size and habitat-diversity indexes (Walsh and Tucker 2020). The δ13C values from opossums in the Midwest and Northeast to test whether opossums rely on anthropogenic trash to survive extreme winters. There was no significant relationship between δ13C and winter variables, but there was a significant increase in variance of Midwest opossums’ δ13C after the 1970 corn agricultural boom (Walsh and Tucker 2023).
- Keyword:
- stable isotope, Virginia opossum, mesopredator, ecology, and mammal
- Citation to related publication:
- Walsh, L.L. and P.K. Tucker. 2020. Habitat heterogeneity is correlated with isotopic niche breadth across the range of a mammalian generalist mesopredator. Ecosphere, 11(12): e03314. https://doi.org/10.1002/ecs2.3314, Walsh, L.L. and P.K. Tucker. 2021. Stable isotope values suggest opossums (Didelphis virginiana) at their northern edge do not seasonally molt. Northeastern Naturalist, 28(1): 1-8. https://doi.org/10.1656/045.028.0101, and Walsh, L.L., and P.K. Tucker. 2023. Evaluating anthropogenic influence on a mesopredator: Opossum (Didelphis virginiana) isotope values influenced by corn agriculture more than urbanization. Canadian Journal of Zoology, 101: https://doi.org/10.1139/cjz-2021-0172.
- Discipline:
- Science
-
- Creator:
- Zongyu Li, Yuni K. Dewaraja, and Jeffrey A. Fessler
- Description:
- Current methods for patient-specific voxel-level dosimetry in radionuclide therapy suffer from a trade-off between accuracy and computational efficiency. Monte Carlo (MC) radiation transport algorithms are considered the gold standard for voxel-level dosimetry but can be computationally expensive, whereas faster dose voxel kernel (DVK) convolution can be sub-optimal in the presence of tissue heterogeneities. Furthermore, the accuracies of both these methods are limited by the spatial resolution of the reconstructed emission image. To overcome these limitations, this paper considers a single deep convolutional neural network (CNN) with residual learning (named DblurDoseNet) that learns to produce dose-rate maps while compensating for the limited resolution of SPECT images. We took the novel approach of constructing a convolutional neural network with residual learning to handle the accuracy-efficiency tradeoff while compensating for the limited resolution of SPECT images. We then test our CNN on clinically relevant phantoms and patients undergoing Lu-177 DOTATATE therapy in our clinic. Our network demonstrated superior results than Monte Carlo, the current gold standard for voxel dosimetry, but only takes a fraction of time. Thus, the DblurDoseNet has the potential for real-time patient-specific dosimetry in clinical treatment planning due to its demonstrated improvement in accuracy, resolution, noise and speed over the DVK/MC approaches. Matlab is needed to access the phantoms and Python (with Numpy package installed) is needed to access the DVKs.
- Keyword:
- Deep learning, Voxel-level dosimetry, Lu-177 therapy, SPECT resolution effects
- Citation to related publication:
- "DblurDoseNet: A Deep Residual Learning Network for Voxel Radionuclide Dosimetry Compensating for SPECT Imaging Resolution" by Zongyu Li, Jeffrey A. Fessler, Justin K. Mikell, Scott J. Wilderman and Yuni K. Dewaraja. Accepted by Medical Physics, 2021. DOI: 10.1002/mp.15397
- Discipline:
- Health Sciences
-
- Creator:
- Sun, Hu, Ren, Jiaen, Chen, Yang, and Zou, Shasha
- Description:
- Our research focuses on providing a fully-imputed map of the worldwide total electron content with high resolution and spatial-temporal smoothness. We fill in the missing values of the original Madrigal TEC maps via estimating the latent feature of each latitude and local time along the 2-D grid and give initial guess of the missing regions based on pre-computed spherical harmonics map. The resulting TEC map has high imputation accuracy and the ease of reproducing. and All data are in HDF5 format and are easy to read using the h5py package in Python. The TEC map is grouped in folders based on years and each file contains a single-day data of 5-min cadence. Each individual TEC map is of size 181*361.
- Keyword:
- Total Electron Content, Matrix Completion, VISTA, Spherical Harmonics, and Spatial-Temporal Smoothing
- Citation to related publication:
- Sun, H., Hua, Z., Ren, J., Zou, S., Sun, Y., & Chen, Y. (2020). Matrix Completion Methods for the Total Electron Content Video Reconstruction. arXiv preprint arXiv:2012.01618. and Zou, S., Ren, J., Wang, Z., Sun, H., & Chen, Y. (2021). Impact of Storm-Enhanced Density (SED) on Ion Upflow Fluxes During Geomagnetic Storm. Frontiers in Astronomy and Space Sciences, 162.
- Discipline:
- Science
-
- Creator:
- Sun, Hu, Ren, Jiaen, Chen, Yang, Zou, Shasha, Chang, Yurui, Wang, Zihan, and Coster, Anthea
- Description:
- Our research focuses on providing a fully-imputed map of the worldwide total electron content with high resolution and spatial-temporal smoothness. We fill in the missing values of the original Madrigal TEC maps via estimating the latent feature of each latitude and local time along the 2-D grid and give initial guess of the missing regions based on pre-computed spherical harmonics map. The resulting TEC map has high imputation accuracy and the ease of reproducing. All data are in HDF5 format and are easy to read using the h5py package in Python. The TEC map is grouped in folders based on years and each file contains a single-day data of 5-min cadence. Each individual TEC map is of size 181*361. and WARNING: 2023-12-01 the data file for 2019-Jan-03 has badly fitted values. Please avoid using it. All other days' files are ready to use.
- Keyword:
- Total Electron Content, Matrix Completion, VISTA, Spherical Harmonics, and Spatial-Temporal Smoothing
- Citation to related publication:
- Sun, H., Hua, Z., Ren, J., Zou, S., Sun, Y., & Chen, Y. (2022). Matrix completion methods for the total electron content video reconstruction. The Annals of Applied Statistics, 16(3), 1333-1358., Sun, H., Chen, Y., Zou, S., Ren, J., Chang, Y., Wang, Z., & Coster, A. (2023). Complete Global Total Electron Content Map Dataset based on a Video Imputation Algorithm VISTA. Scientific Data, in press., and Zou, S., Ren, J., Wang, Z., Sun, H., & Chen, Y. (2021). Impact of storm-enhanced density (SED) on ion upflow fluxes during geomagnetic storm. Frontiers in Astronomy and Space Sciences, 8, 746429.
- Discipline:
- Science and Engineering
-
- Creator:
- Revzen, Shai
- Description:
- This repository contains both the data and python3 code that reads this data and reproduces the relevant figures. The code depends on NumPy >1.17 and matplotlib >3.1 and was tested on python 3.8
- Keyword:
- locomotion, slipping, low Reynolds number, walking, and slithering
- Discipline:
- Science and Engineering
-
- Creator:
- Hepner, Shadrach, T
- Description:
- This data provided evidence of the presence of a lower hybrid drift instability in a magnetic nozzle. It was used in DOI: 10.1063/5.0012668 to estimate the effective electron collision frequency that it induced in the context of cross-field electron transport. It is also used to determine the effective reduction in heat flux resulting from propagation along magnetic field lines in an upcoming work.
- Keyword:
- Magnetic nozzle, heat flux, plasma instabilities
- Citation to related publication:
- Hepner, S., Jorns, B. (2020). Wave-driven non-classical electron transport in a low temperature magnetically expanding plasma. Appl. Phys. Lett, 116(263502). https://doi.org/10.1063/5.0012668
- Discipline:
- Engineering
-
- Creator:
- Heath, Jeffrey
- Description:
- Documentary videos of weaving (garments, baskets) and dyeing. Credits are at the end of videos. Additional documentaries from Mali may be added later.
- Keyword:
- weaving, basketry, indigo, and bogolan (dye)
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey
- Description:
- This is the flora-fauna lexical material obtained in the course of more general lexical and grammatical fieldwork on languages of central-eastern Mali (Dogon, Songhay, Bangime, Bozo). The spreadsheets in this work, duplicated in xlsx and csv formants, present our flora-fauna lexicons as of early 2019 for many languages of central-eastern Mali, and certain languages of southwestern Burkina Faso. The Malian data is in two spreadsheets (flora, fauna), while the Burkina data is in separate spreadsheets for flora, birds, fish, insects, lizards and snakes, and mammals. Please begin with the “readme” document.
- Keyword:
- flora,, fauna, lexicon, Mali, and Burkina Faso
- Citation to related publication:
- Moran, Steven & Forkel, Robert & Heath, Jeffrey (eds.) 2016. Dogon and Bangime Linguistics. Jena: Max Planck Institute for the Science of Human History. https://dogonlanguages.org and Christfried Naumann & Tom Güldemann & Steven Moran & Guillaume Segerer & Robert Forkel (eds.) 2015. Tsammalex: A lexical database on plants and animals. Leipzig: Max Planck Institute for Evolutionary Anthropology. https://tsammalex.clld.org
- Discipline:
- Humanities
-
- Creator:
- Johnson, JE and Molnar, PH
- Description:
- This IF compilation was assembled from the existing literature to understand if preservation biases affected the record of iron formations.
- Keyword:
- Archean ocean chemistry, temporal record of iron formations, and early Earth iron cycle
- Citation to related publication:
- Johnson, J. E., & Molnar, P. H. ( 2019). Widespread and persistent deposition of iron formations for two billion years. Geophysical Research Letters, 46, 3327– 3339. https://doi.org/10.1029/2019GL081970
- Discipline:
- Science
-
- Creator:
- Cody H. Pham, Jason M. Tallant, J. Jordan Price, and David N. Karowe
- Description:
- Anthropogenic climate change will dramatically alter species distributions. The rate and magnitude of range shifts, however, will differ among taxa, resulting in altered patterns of co-occurrence and interspecific interactions. We examined potential climate-mediated breeding range shifts among North American wood-warblers (Parulidae), a speciose avian family likely to be especially impacted by such changes. We used publicly available species distribution model (SDM) range outputs to compare current ranges and patterns of sympatry among warbler species to future ranges and sympatry under 1.5 °C, 2.0 °C, and 3.0 °C of average global warming. We used these outputs to calculate average breeding range area, range overlap among species, number of sympatric species, and distances of breeding range shifts. We additionally calculated the number gained and lost sympatric interactions under each warming scenario.
- Keyword:
- wood-warbler, University of Michigan Biological Station (UMBS), Research Experience for Undergraduates (REU), climate change, interspecific, range shift, species distribution models, sympatric, and student-friendly
- Discipline:
- Science
-
- Creator:
- Steiner, Allison and Kawecki, Stacey
- Description:
- WRF-Chem model
- Keyword:
- aerosols and weather
- Citation to related publication:
- Kawecki, S., Steiner, A.L., 2018. The Influence of Aerosol Hygroscopicity on Precipitation Intensity During a Mesoscale Convective Event. Journal of Geophysical Research: Atmospheres 123, 424–442. https://doi.org/10.1002/2017JD026535
- Discipline:
- Science
-
- Creator:
- Steiner, A.L. and Kawecki, S.
- Description:
- Kansas City, MO emissions can affect a severe weather system by altering the number of CCN, which drives changes in the hydrometeor development. The hydrometeor changes affect cold pool strength, size, and propagation which ultimately determine the strength of the squall line that crosses Kansas City, MO.
- Keyword:
- Great Plains, aerosols, mesoscale convective systems, and weather
- Citation to related publication:
- Kawecki, S., G.M. Henebry, and A.L. Steiner, 2016: Effects of Urban Plume Aerosols on a Mesoscale Convective System. J. Atmos. Sci., 73, 4641–4660, https://doi.org/10.1175/JAS-D-16-0084.1
- Discipline:
- Science
-
- Creator:
- Modey, Christine A., Cheatle, Joseph, and Giaimo, Genie N.
- Description:
- Data includes information regarding session notes from sixty-three institutions, including blank session note forms, data sets of completed session notes, and survey data about how sessions notes are conceived of, and used, in writing centers.
- Keyword:
- session note, client report form, tutor notes, writing center, writing, and tutor
- Citation to related publication:
- Christine Modey, Genie Giaimo, and Joseph Cheatle. “Session Notes: Preliminary Results from a Cross-Institutional Survey.” Praxis: A Writing Center Journal 18.3 (2021): 52-75. https://issuu.com/titospanks/docs/18.3_summer_2021_full_issue_2._pdf
- Discipline:
- Humanities
-
- Creator:
- Moniri, Saman, Xiao, Xianghui, and Shahani, Ashwin J.
- Description:
- The data file is comprised of 22,500 X-ray projections (15 scans of 1500 projections each) recorded during solidification of Al-Ge-Na. The raw data file is in .hdf format and can be reconstructed into .tiff, e.g., by using the TomoPy toolbox in Python.
- Keyword:
- X-ray microtomography, synchrotron, in situ, 4D materials science, irregular eutectic, growth, and solidification
- Citation to related publication:
- Moniri, S., Xiao, X., & Shahani, A. J. (2019). The mechanism of eutectic modification by trace impurities. Scientific Reports, 9(1), 3381. https://doi.org/10.1038/s41598-019-40455-3
- Discipline:
- Engineering
-
- Creator:
- Holmes, Iris A, Monagan Jr., Ivan V, Westphal, Michael F, and Davis Rabosky, Alison R
- Description:
- We generated these data from desert night lizards, Xantusia vigilis, from populations in central California. We performed phylogeographic analyses based on these data.
- Keyword:
- ddRADseq, phylogeography, Xantusia vigilis, lizard, and genome-scale sequencing
- Discipline:
- Science
-
- Creator:
- Lim, Hongki and Dewaraja, Yuni K.
- Description:
- Interest in quantitative imaging of Y-90 is growing because transarterial radioembolization (RE) with Y-90 loaded microspheres is a promising and minimally invasive treatment that is FDA approved for unresectable primary and metastatic liver tumors. These cancers are a leading cause of cancer mortality and morbidity. Radioembolization is a therapy that irradiates liver tumors with radioactive microspheres administered through a microcatheter placed in the hepatic arterial vasculature. Radioembolization is based on the principle that healthy liver and tumor are mainly vascularized by the portal vein and the hepatic artery respectively. As a result, radioactive microspheres are preferentially located in the lesions after they are administered via the hepatic artery.
- Keyword:
- Y-90, PET, SPECT, CT, Segmentation, Organ, Tumor, Label
- Citation to related publication:
- Van, B. J., Dewaraja, Y. K., Sangogo, M. L., & Mikell, J. K. (2021). Y-90 SIRT: Evaluation of TCP variation across dosimetric models. EJNMMI Physics, 8(1), 45. https://doi.org/10.1186/s40658-021-00391-6
- Discipline:
- Health Sciences
-
- Creator:
- Van, Benjamin J. and Dewaraja, Yuni K.
- Description:
- Interest in quantitative imaging of Y-90 is growing because transarterial radioembolization (RE) with Y-90 loaded microspheres is a promising and minimally invasive treatment that is FDA approved for unresectable primary and metastatic liver tumors. These cancers are a leading cause of cancer mortality and morbidity. Radioembolization is a therapy that irradiates liver tumors with radioactive microspheres administered through a microcatheter placed in the hepatic arterial vasculature. Radioembolization is based on the principle that healthy liver and tumor are mainly vascularized by the portal vein and the hepatic artery respectively. As a result, radioactive microspheres are preferentially located in the lesions after they are administered via the hepatic artery.
- Keyword:
- Y-90, PET, SPECT, CT, Segmentation, Organ, Tumor, Label, Microsphere, Radioembolization, and SIRT
- Citation to related publication:
- Van, B. J., Dewaraja, Y. K., Sangogo, M. L., & Mikell, J. K. (2021). Y-90 SIRT: Evaluation of TCP variation across dosimetric models. EJNMMI Physics, 8(1), 45. https://doi.org/10.1186/s40658-021-00391-6
- Discipline:
- Health Sciences
-
- Creator:
- Heath, Jeffrey
- Description:
- Images of villages in Mali in which Yanda Dom (Dogon family) is the primary language. Each file name contains important information about the photos, and are structured thus: LanguageFamily_Language_IdentificationNumber_GeographicCoordinate_Description_Date_InitialsOfThePhotographer
- Keyword:
- villages, Dogon, Yanda Dom, and Mali
- Citation to related publication:
- Moran, Steven & Forkel, Robert & Heath, Jeffrey (eds.) 2016. Dogon and Bangime Linguistics. Jena: Max Planck Institute for the Science of Human History. http://dogonlanguages.org
- Discipline:
- Humanities
-
Zagorë
User Collection- Creator:
- Galaty, Michael
- Description:
- The following works contain the databases, field notebooks, unit and profile drawings, photographs, photo descriptions, radiocarbon dates, and geophysical survey data related to the Zagorë settlement excavation.
- Keyword:
- archaeology
- Discipline:
- Science and Humanities
4Works