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- Creator:
- Lim, Hongki and Dewaraja, Yuni K.
- Description:
- Internally administered targeted radionuclide therapy (TRT) with radio-labelled targeting molecules that deliver cytotoxic radiation to tumor has been used successfully to treat multiple cancers. Lu-177, used increasingly in TRT, emits both beta particles that deliver the therapeutic effect. FDA recently approved a fixed activity (4 cycles of 7.4 GBq/cycle as in NETTER -1) administered every 8 weeks. With the patient studies under this treatment, we collected CT images and corresponding volume of interest (organs, lesions) contours.
- Keyword:
- Lu-177, CT, Segmentation, Organ, Tumor, Label
- Discipline:
- Health Sciences
-
- Creator:
- Huang, Yihe (University of Michigan); De Barros, Louis (Université Côte d’Azur)
- Description:
- Numerous small and moderate injection-induced earthquakes have been recorded in North America, Europe and Asia. Here we present a detailed analysis about microearthquakes in an in-situ injection-induced earthquake experiment, which provides an unprecedented opportunity to investigate the mechanisms of induced earthquakes. Our analysis illuminates meter-scale earthquake sources distributed in a network of preexisting rock fractures. The majority of induced earthquakes in our analysis happened when injection pressure reached a peak, indicating a direct response of rock fractures to fluid pressure perturbation. But the relatively low ratio of stress drop to crustal strength reveals that a very small fraction of the crustal shear strength is released by earthquakes, supporting the previous notion that fluid injection induces large aseismic deformation during the experiment. and Citation for dataset: Huang, Y., De Barros, L. (2019). Seismograms of earthquake pairs in the injection experiment [Data set]. University of Michigan - Deep Blue.
- Keyword:
- Induced seismicity
- Citation to related publication:
- Huang, Y., De Barros, L., Cappa, F. (2019). Illuminating the Rupturing of Microseismic Sources in an Injection‐Induced Earthquake Experiment. Geophysical Research Letters, 46(16), 9563-9572. https://doi.org/10.1029/2019GL083856
- Discipline:
- Science
-
- Creator:
- Jialei Zhu and Joyce E. Penner
- Description:
- The dataset contains the Fortran programs applied in the latest CESM/IMPACT model as well as the data created from this model, which are used in the referenced paper.
- Keyword:
- Second organic aerosol, Radiative effect, and Cirrus cloud
- Citation to related publication:
- Zhu, J and Penner, J. E.: Indirect effects of secondary organic aerosol on cirrus clouds, (2019), Journal of Geophysical Research: Atmospheres, https://doi.org/10.1029/2019JD032233
- Discipline:
- Science
-
- Creator:
- Wang, Yi and Hendy, Ingrid L.
- Description:
- The dataset contains bulk sedimentary d15N, TOC, and TN data measured every 2 mm on the core SPR0901-03KC. Flood and turbidite layers are shaded with blue and orange in the files. and This work is supported by NSF OCE-1304327.
- Keyword:
- d15N, total organic carbon, nitrogen isotopes, SPR0901-03KC, and Santa Barbara Basin
- Citation to related publication:
- Wang, Y. , Hendy, I. L. and Thunell, R. (2019), Local and remote forcing of denitrification in the Northeast Pacific for the last 2000 years. Paleoceanography and Paleoclimatology. Volume 34, issue 8, pages 1517-1533. https://doi.org/10.1029/2019PA003577
- Discipline:
- Science
-
- Creator:
- Moniri, Saman, Bale, Hrishikesh , Volkenandt, Tobias, Wang, Yeqing, Gao, Jianrong, Lu, Tianxian, Sun, Kai, and Shahani, Ashwin J.
- Description:
- The data file contains (1) the grayscale images of the nano-tomography experiments that can be segmented into binary images and visualized to show the 3D morphology of spiral eutectics; and (2) crystallographic orientation maps of serial-sectioned sample, which can be processed in a variety of EBSD software packages.
- Keyword:
- crystallization, chirality, self-organization, and spiral eutectics
- Citation to related publication:
- Moniri, S., Bale, H., Volkenandt, T., Wang, Y., Gao, J., Lu, T., Sun, K., Ritchie, R.O., & Shahani, A.J. (23 January 2020). Multi‐Step Crystallization of Self‐Organized Spiral Eutectics. Small (1906146). https://doi.org/10.1002/smll.201906146
- Discipline:
- Engineering
-
- Creator:
- Abid, Chaima, Kessentini, Marouane, Alizadeh, Vahid, Dhaouadi, Mouna, and Kazman, Rick
- Description:
- Data about the evaluation of the refactorings impact on security.
- Discipline:
- Science
-
- Creator:
- Moniri, Saman and Shahani, Ashwin J.
- Description:
- The data is comprised of 20 .hdf files of the X-ray projections recorded during isothermal annealing of Zn-Mg samples, at discrete time-steps shown below for files names ending in ‘...30141’ to ‘…30161’: 30141: prior to annealing; 30142: 1 min annealing; 30143: 3 min; 30144: 5 min; 30145: 7 min; 30146: 10 min; 30147: 15 min; 30148: 20 min; 30150: 31 min; 30151: 1 hr; 30152: 2 hr; 30153: 3 hr; 30154: 4 hr; 30155: 5 hr; 30156: 6 hr; 30157:7 hr; 30158: 8 hr; 30159:9 hr; 30160: 9 hr, 10 min; 30161: 10 hr The raw data file is in .hdf format and can be reconstructed into .tiff, e.g., by using the TomoPy toolbox in Python.
- Keyword:
- Spiral eutectics
- Discipline:
- Engineering
-
S’Urachi Site-Based Archaeological Survey
User Collection
- Creator:
- Gosner, Linda R.
- Description:
- This data was produced by the site-based archaeological survey at the nuraghe S'Urachi in west-central Sardinia (San Vero Milis, Oristano, Sardinia). The survey was carried out from 2015-2017 as a part of the ongoing Progetto S'Urachi, an archaeological project that aims to understand daily life around the monumental Bronze Age tower of S'Urachi during the later occupation of the landscape over the course of the 1st millennium BCE.
- Keyword:
- Mediterranean archaeology, Sardinia, Archaeological Survey, Excavation, and Classical Archaeology
- Discipline:
- Social Sciences
2Works -
- Creator:
- Huang, Cheng MI
- Description:
- This collection contains a hierarchy of test problems for turbulent reacting flow simulations. It is meant to provide a testbed to build reduced model for relevant challenging reacting flow problems using different methods. In addition, this collection also serves to engage a broad community of experts in computational science and the field of engineering to address certain challenges in constructing reduced models for reacting flow simulations. All the datasets in this collection were generated under the Air Force Center of Excellence on Multi-Fidelity Modeling of Rocket Combustion Dynamics and the goal of the center is to advance the state-of-the-art in Reduced Order Models (ROMs) and enable efficient and accurate prediction of instabilities in liquid fueled rocket combustion systems.
- Discipline:
- Engineering
2Works -
Defect patterns on the curved surface of fish retinae suggest a mechanism of cone mosaic formation
User Collection
- Creator:
- Nunley, Hayden, Nagashima, Mikiko, Martin, Kamirah, Lorenzo Gonzalez, Alcides, Suzuki, Sachihiro C., Norton, Declan A., Wong, Rachel O. L., Raymond, Pamela A., and Lubensky, David K.
- Description:
- The outer epithelial layer of zebrafish retinae contains a crystalline array of cone photoreceptors, called the cone mosaic. As this mosaic grows by mitotic addition of new photoreceptors at the rim of the hemispheric retina, topological defects, called “Y-Junctions”, form to maintain approximately constant cell spacing. The generation of topological defects due to growth on a curved surface is a distinct feature of the cone mosaic not seen in other well-studied biological patterns like the R8 photoreceptor array in the _ Drosophila compound eye. Since defects can provide insight into cell-cell interactions responsible for pattern formation, here we characterize the arrangement of cones in individual Y-Junction cores (see Set of images for Figures 1 and 2 and 6 and Supplementary Figure 7) as well as the spatial distribution of Y-junctions across entire retinae (see Dataset for analyzing spatial distribution of Y-junctions in flat-mounted retinae). We find that for individual Y-junctions, the distribution of cones near the core corresponds closely to structures observed in physical crystals (see Set of images for Figures 1 and 2 and 6 and Supplementary Figure 7). In addition, Y-Junctions are organized into lines, called grain boundaries, from the retinal center to the periphery (see Dataset for analyzing spatial distribution of Y-junctions in flat-mounted retinae and Dataset for measuring tendency of Y-junctions to line up into grain boundaries during incorporation into retinae). In physical crystals, regardless of the initial distribution of defects, defects can coalesce into grain boundaries via the mobility of individual particles. By imaging in live fish, we demonstrate that grain boundaries in the cone mosaic instead appear during initial mosaic formation, without requiring defect motion (see Dataset for measuring tendency of Y-junctions to line up into grain boundaries during incorporation into retinae and Dataset for analyzing Y-junction motion in live fish retinae). Motivated by this observation, we show that a computational model of repulsive cell-cell interactions generates a mosaic with grain boundaries (see Code and example simulations of phase-field crystal model (for cone mosaic formation)). In contrast to paradigmatic models of fate specification in mostly motionless cell packings (see Code and accompanying input data for simulating lateral inhibition on motionless cell packing), this finding emphasizes the role of cell motion, guided by cell-cell interactions during differentiation, in forming biological crystals. Such a route to the formation of regular patterns may be especially valuable in situations, like growth on a curved surface, where the resulting long-ranged, elastic, effective interactions between defects can help to group them into grain boundaries.
- Keyword:
- zebrafish cone mosaic, lattice vectors, topological defects, tissue patterning, grain boundaries, lateral inhibition, photoconversion, phase-field crystal model, and defect motion
- Discipline:
- Science
7Works -
Lu-177 DOTATATE Anonymized Patient Datasets
User Collection
- Creator:
- Dewaraja, Yuni K and Van, Benjamin J
- Description:
- This collection is comprised of a number of works that collectively represent the imaging studies and information necessary for dosimetric analysis of a patient treated with Lutathera. All works may be used as standalone datasets or in conjunction with the others in this collection depending on the analysis performed. Files are stored using the DICOM standard widely accepted for storage and transmission of medical images and related information. All patient private information has been anonymized using MIM commercial software (MIM Software Inc.). Data from 2 patients, referred to as patient 4 and patient 6, has been provided in this collection and is divided among 6 works as outlined below:, 1) Pre-Therapy Diagnostic Images. Description: Patient diagnostic scans performed prior to Lutathera treatment. Used for identifying lesions and measuring progression. Note that the date of the baseline scan may be several months before the Lutathera treatment and changes in the anatomy are possible. Files: (1) Ga68 Dotatate PET/CT, Either: (1) MRI, (1) standalone diagnostic CT, 2) Planar Whole Body Scans. Description: Planar whole body Lu-177 scans taken at 4 time points within a week after treatment. Two views (Anterior and Posterior) and 3 energy windows (one main window at 208 keV and 2 adjacent scatter windows) are available for each time point. The units of this image is counts. Energy window information, acquisition data/time and duration can be found in DICOM header. Files: (6) individual images at each time point (24 total images per patient) , 3) SPECT/CT Scans. Description: Lu-177 SPECT/CT scans at 4 time points within a week after treatment (same time points as the planar scans). Images were acquired on a Siemens Intevo system and reconstructed using xSPECT Quant. The units of this image is Bq/mL. Information on the reconstruction, acquisition date/time, duration, Lu-177 administration time and activity can be found in the DICOM header. Files: (1) Folder with reconstructed SPECT slices per time point (4 folders total per patient), (1) Folder containing co-registered CT slices per time point (4 folders total per patient), 4) Lesion and Organ Volumes of Interest. Description: DICOM RT structure files containing organ and lesion volumes of interest (VOI) that were defined on the CT of the scan1 SPECT/CT in 3). Organs were defined using semi-automatic tools (atlas based and CNN-based) while lesions were defined manually by a radiologist guided by baseline scans. Only lesions >2 cc were defined. Files: (1) File containing organ contours, (1) File containing lesion contours, 5) Time Integrated Activity Maps. Description: A DICOM file containing the time-integrated activity map over all 4 time points within a week after treatment. This combines the SPECT/CT scans provided in 3) into a single integrated activity map. This map was generated via the MIM MRT Dosimetry package: The 4 time points were registered to the reference SPECT scan (time point 1) using a contour intensity based SPECT alignment and the voxel-level time-activity data was fit using exponential functions. Voxel-level integration was performed to generate the TIA map. The units of this image is Bq/mL * sec. Files: (1) Folder with Time-integrated activity image per patient, and 6) Projection Data and CT based Attenuation Coefficient Maps. Description: SPECT projection data for each of the 4 Lutathera scans taken within a week after treatment is provided in 3 forms: unaltered, Siemens [Reformatted], and Siemens [Advanced]. The difference between the Projections and the [Advanced] Projections is that the [Advanced] consists of uncorrected raw projection data and the other the corrected projection data (e.g. camera uniformity corrections). The [Advanced] projections are used in xSPECT reconstruction (where all corrections are done during the reconstruction), while the other is used in Flash 3D reconstruction. CT-based attenuation coefficient maps (mumaps) are provided for each of the 4 scans taken within a week after treatment. Two methods are provided for each mumap: xSPECT and F3D as the matrix size is different for the 2 cases (256 x 256 for xSPECT and 128 x 128 for Flash3D). Files: (3) Folders containing raw SPECT projections, (2) Folders containing CT attenuation coefficient maps (mumaps)
- Keyword:
- Lu-177, Lutathera, Dosimetry, Radionuclide, and CTMRIPET
- Discipline:
- Health Sciences
6Works -
- Creator:
- Figueroa, Carlos A., Computational Vascular Biomechanics Lab, University of Michigan, and et al.
- Description:
- This collection concerns the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational haemodynamics studies via a pipeline which involves: 1) segmenting vascular structures from medical images; 2) constructing analytic arterial and venous geometric models; 3) performing finite element mesh generation; 4) designing, and 5) applying boundary conditions; 6) running incompressible Navier-Stokes simulations of blood flow with fluid-structure interaction capabilities; and 7) post-processing and visualizing the results, including velocity, pressure and wall shear stress fields. , The minimum specifications to run CRIMSON are: Any AMD64 CPU (note: Intel Core i series are AMD64), Windows (only tested on Windows 10 but might work on Windows 7), 8 GB of RAM , If you are running non-trivial models you will want to have: Quad core CPU or higher, Solid state drive for storing data, Windows, 16 GB of RAM, Dedicated discrete GPU for rendering models. , and Software in this collection is a snapshot; please visit https://github.com/carthurs/CRIMSONGUI & www.crimson.software for more general information and the most up to date version of the software.
- Keyword:
- Blood Flow Simulation, Patient-specific, Open-source Software, Image-based simulation, Cardiovascular Medical Image, Segmentation, and Finite Element Simulation
- Citation to related publication:
- CRIMSON: An Open-Source Software Framework for Cardiovascular Integrated Modelling and Simulation C.J. Arthurs, R. Khlebnikov, A. Melville, et al. bioRxiv 2020.10.14.339960; doi: https://doi.org/10.1101/2020.10.14.339960
- Discipline:
- Health Sciences and Engineering
4Works -
- Creator:
- Gainsburg, Izzy and Earl, Allison
- Description:
- This research explores trigger warnings as an interpersonal emotion-regulation strategy, introducing a temporal dimension to interpersonal emotion-regulation by regulating others' future, anticipated emotions. Across studies, believing that trigger warnings are protective (versus coddling) increased their effect on anticipated negative affect, but weakened their effect on experienced negative affect. Study 1 demonstrated that anticipated anxiety for warned-of content predicts intentions to avoid information. Furthermore, beliefs about trigger warnings as protective (versus coddling) best predicted anticipated anxiety for warned-of content and subsequent intentions to avoid. In Study 2, participants had higher anticipated negative affect for videos with trigger warnings, compared to those without, and this mediated increased avoidance for warned-of videos. In Study 3, trigger warnings preceding essays increased anticipated negative affect and attentional-regulation strategies, but reduced experiences of negative affect. For more information, please see the article Gainsburg, I., & Earl, A. (2018). Trigger warnings as an interpersonal emotion-regulation tool: Avoidance, attention, and affect depend on beliefs. Journal of Experimental Social Psychology, 79, 252–263. https://doi.org/10.1016/j.jesp.2018.08.006
- Citation to related publication:
- Gainsburg, I., & Earl, A. (2018). Trigger warnings as an interpersonal emotion-regulation tool: Avoidance, attention, and affect depend on beliefs. Journal of Experimental Social Psychology, 79, 252–263. https://doi.org/10.1016/j.jesp.2018.08.006
- Discipline:
- Social Sciences
-
- Creator:
- Wen, Ai, Foxman. Betsy, Srinivasan, Usha , Goldberg, Deborah , Marrs, Carl F , Owen, John, Wing, Deborah A., Misra, Dawn , Cronenwett, Anna , Ponnaluri, Sreelatha, Miles-Jay, Arianna, Bucholz, Brigette, and Abbas, Khadija
- Description:
- This is the bacterial DNA data extracted from the gram stain slides. The targeted bacteria genera and species include: Atopobium spp., bacterial vaginosis-associated bacterium (BVAB) types 1, 2 and 3 in the order Clostridiales, Escherichia coli, Gardnerella vaginalis, Group B Streptococcus, Lactobacillus spp., Mobiluncus spp., Mycoplasma spp., and Ureaplasma spp. We also used a primer set for Lactic Acid Bacteria (LAB) that includes lactic acid producing bacteria of the genera Lactobacillus, Pediococcus, Leuconostoc, and Weissella. We calculated the relative proportion of each bacterial taxon using the bacterial copies measured by each specific bacteria primer divided by the total bacterial copies. The limit of detection was 100 copies and readings lower than the limit were considered negative
- Citation to related publication:
- Wen A, Srinivasan U, Goldberg D, Owen J, Marrs CF, Misra D, Wing DA, Ponnaluri S, Miles-Jay A, Bucholz B, Abbas K, Foxman B. Selected vaginal bacteria and risk of preterm birth: an ecological perspective. J Infect Dis. 2014 Apr 1;209(7):1087-94. https://doi.org/10.1093/infdis/jit632. Epub 2013 Nov 22. PMID: 24273044; PMCID: PMC3952673. and Foxman B, Wen A, Srinivasan U, Goldberg D, Marrs CF, Owen J, Wing DA, Misra D. Mycoplasma, bacterial vaginosis-associated bacteria BVAB3, race, and risk of preterm birth in a high-risk cohort. Am J Obstet Gynecol. 2014 Mar;210(3):226.e1-7. https://doi.org/10.1016/j.ajog.2013.10.003. Epub 2013 Oct 4. PMID: 24096128; PMCID: PMC3943817.
- Discipline:
- Health Sciences
-
- Creator:
- Kue, Jessie and Meurer, William
- Description:
- NHAMCS is an annual survey of emergency department visits. and SAS programs are required to read this data.
- Keyword:
- emergency department and hypertension
- Citation to related publication:
- Kue, J., & Meurer, W. (2020). Association between blood pressure, race, ethnicity and likelihood of admission to the hospital from United States emergency departments – A cross sectional study. F1000Research, 9, 1116. https://doi.org/10.12688/f1000research.24757.1
- Discipline:
- Health Sciences
-
- Creator:
- Hatch, Nan E.
- Description:
- Crouzon FGFR2-C342Y/+ and wild type littermate pups on a BALB/c congenic background were injected with lentivirus expressing TNAP enzyme or phosphate buffered saline shortly after birth. Mice were euthanized 4 weeks after birth for analyses.
- Keyword:
- craniofacial, bone, craniosynostosis, FGFR2, TNAP, mouse model, and development
- Discipline:
- Health Sciences
-
- Creator:
- Liu, Y , Ettinger, AS, Téllez-Rojo, M, Sánchez, BN, Zhang, ZZ, Cantoral, A, and Hu, H
- Description:
- We used data collected from participants of the Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) study, which consists of three sequentially-enrolled birth cohorts of pregnant women. Research protocols of this study were approved by the Institutional Review Board at University of Michigan and the Mexico National Institute of Public Health. We obtained informed consent from mothers and informed assent from children prior to enrollment.
- Citation to related publication:
- Liu, Y., Ettinger, A. S., Téllez-Rojo, M., Sánchez, B. N., Zhang, Z., Cantoral, A., Hu, H., & Peterson, K. E. (2020). Prenatal Lead Exposure, Type 2 Diabetes, and Cardiometabolic Risk Factors in Mexican Children at Age 10–18 Years. The Journal of Clinical Endocrinology & Metabolism, 105(1), 210–218. https://doi.org/10.1210/clinem/dgz038
- Discipline:
- Health Sciences
-
- Creator:
- Hall, Ryan J. and Larson, Ronald G.
- Description:
- This is data is a large assortment of over 50 1,4-polybutadiene star-linear blends that can be used for assessing and developing predictive models. The data are presented in CSV files.
- Keyword:
- polymers, rheology, star-linear polymer blends, and shear rheology
- Citation to related publication:
- Hall, R., Desai, P. S., Kang, B.-G., Huang, Q., Lee, S., Chang, T., Venerus, D. C., Mays, J., Ntetsikas, K., Polymeropoulos, G., Hadjichristidis, N., & Larson, R. G. (2019). Assessing the Range of Validity of Current Tube Models through Analysis of a Comprehensive Set of Star–Linear 1,4-Polybutadiene Polymer Blends. Macromolecules, 52(20), 7831–7846. https://doi.org/10.1021/acs.macromol.9b00642
- Discipline:
- Science and Engineering
-
- Creator:
- Wang, Zihan
- Description:
- SWMF is used to study the segmentation of SED plume into polar cap patches during the geomagnetic storm on Sep 7, 2017. The database includes the 3D output in the upper atmosphere from GITM, the 2D output from Ionospheric Electrodynamics (IE) and 3D output from BATSRUS. The output from GITM can be read with thermo_batch_new.pro. The output from IE can be opened with Spacepy at https://pythonhosted.org/SpacePy/. The output from BATSRUS can be opened with tecplot. More details can be found in Readme.txt.
- Keyword:
- MHD and Ionosphere
- Citation to related publication:
- Wang, Z., Zou, S., Coppeans, T., Ren, J., Ridley, A., & Gombosi, T. (2019). Segmentation of SED by Boundary Flows Associated With Westward Drifting Partial Ring current. Geophysical Research Letters, 46(14), 7920–7928. https://doi.org/10.1029/2019GL084041
- Discipline:
- Science
-
- Creator:
- Yao, Mengqi, Mathieu, Johanna L., Hiskens, Ian A., Molzahn, Daniel K., Koorehdavoudi, Kasra , and Roy, Sandip
- Description:
- The files include all the published paper and presentation source codes. Please install Matpower before running the code. The Matpower version is 5.1, which can be found in https://matpower.org/download/ Talks, papers, and poster in Deep Blue: http://hdl.handle.net/2027.42/150104
- Keyword:
- Demand response, Optimal power flow, Power system voltage stability, and Power system small signal stability L
- Citation to related publication:
- Yao, M., Molzahn, D. K., & Mathieu, J. L. (2019). An Optimal Power-Flow Approach to Improve Power System Voltage Stability Using Demand Response. IEEE Transactions on Control of Network Systems, 6(3), 1015–1025. https://doi.org/10.1109/TCNS.2019.2910455, Yao, M., Mathieu, J. L., & Molzahn, D. K. (2017). Using demand response to improve power system voltage stability margins. 2017 IEEE Manchester PowerTech, 1–6. https://doi.org/10.1109/PTC.2017.7980798 , Koorehdavoudi, K., Yao, M., & Mathieu, J. (2017). Using Demand Response to Shape the Fast Dynamics of the Bulk Power Network. https://www.semanticscholar.org/paper/Using-Demand-Response-to-Shape-the-Fast-Dynamics-of-Koorehdavoudi-Yao/6799c161744c29e7603e3601daa284ecc84788a8, Yao, M., Hiskens, I. A., & Mathieu, J. L. (2018). Improving Power System Voltage Stability by Using Demand Response to Maximize the Distance to the Closest Saddle-Node Bifurcation. 2018 IEEE Conference on Decision and Control (CDC), 2390–2395. https://doi.org/10.1109/CDC.2018.8619091 , and Yao, M., Molzahn, D. K., & Mathieu, J. L. (2017). The impact of load models in an algorithm for improving voltage stability via demand response. 2017 55th Annual Allerton Conference on Communication, Control, and Computing (Allerton), 149–156. https://doi.org/10.1109/ALLERTON.2017.8262731
- Discipline:
- Engineering