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Supplemental Data for "Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge"

Creator:

Tronson, Natalie C and Tchessalova, Daria

Description:

The main goal of this research was to identify potential molecular pathways that contribute to memory dysregulation and decline that persists long after illness or inflammation. We have previously established a subchronic immune challenge model that results in memory impairments months after the inflammatory challenge. This project aimed to determine whether memory impairments were accompanied by transcriptional dysregulation in memory related brain region (the hippocampus). These data show the differential gene expression as log2fold change (and p-value) in males and females 3 months after immune challenge (Supp Tables 1 and 2); after a subsequent immune challenge (Supp Tables 3 and 4); the differential regulation of genes in males and females (Supp Table 5); genes differentially expressed in the hippocampus of males and females at baseline (Supp Table 6) and the differential regulation of those genes in males and females after immune challenge (Supp Tables 7,8).

Keyword:

hippocampus, lipopolysaccharide, differential gene expression, RNA sequencing, neuroimmune, sex differences, learning and memory, and inflammation

Citation to related publication:

Tchessalova, D., & Tronson, N. C. (2019). Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge. BioRxiv, 566570. https://doi.org/10.1101/566570

Discipline:

Science and Health Sciences
Untargeted lipidomics and targeted metabolomics analysis of Cardiolipin synthase deficient murine macrophages

Creator:

Reynolds, Mack B., Hong, Hanna S., Zhang, Li, Lyssiotis, Costas A., and O'Riordan, Mary X.

Description:

Untargeted lipidomics (Data S1) and targeted metabolomics (Data S2) analysis from in vitro culture of a murine macrophage cell line expressing shRNA targeted to Cardiolipin synthase (CRLS1), referred to as CRLS1 knockdown (KD), or a paired non-target shRNA-expressing (NT-Control). CRLS1 KD and NT-Control macrophages were either directly analyzed (untargeted lipidomics) or stimulated with lipopolysaccharide for a variety of timepoints and then analyzed (targeted metabolomics). Datasets are available as .csv files.

Keyword:

Lipidomics, Metabolomics, Cardiolipin, Macrophage, CRLS1, lipopolysaccharide, and LPS

Citation to related publication:

Reynolds M.B. et al. (2023). Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. Science Advances, 9(5). DOI: 10.1126/sciadv.ade8701

Discipline:

Health Sciences

Supplemental Data for "Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge"

Untargeted lipidomics and targeted metabolomics analysis of Cardiolipin synthase deficient murine macrophages

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Supplemental Data for "Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge"

Untargeted lipidomics and targeted metabolomics analysis of Cardiolipin synthase deficient murine macrophages

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