GRAND is a five-year, cluster randomized controlled trial. The study is registered on ClinicalTrials.gov, [ID#: NCT04033003] and is a collaboration between University of Michigan in the United States and the Dodowa Health Research Center in Ghana. , The study setting for GRAND is four districts (Akwapim North, Yilo Krobo, Nsawam-Adoagyiri, and Lower Manya Krobo) within the Eastern Region of Ghana. Health facilities were selected based the number ANC registrants per month and average gestational age of women at registration in each facility., and Facilities were then matched based on facility type, district, and number of monthly ANC registrants.
A cluster randomized controlled trial was conducted in 14 facilities in four districts of the Eastern Region of Ghana. Health facilities were randomized using a matched pairs design; each pair was similar in the number of deliveries and average gestational age of the women at enrollment in antenatal care.
The locations of the facilities were far enough apart to avoid cross-group contamination. In each pair of facilities, one was randomly assigned to the intervention (G-ANC) and the other to the control (I-ANC). Recruitment began July 2019 and ended when enrollment targets were met.
Data collection ended July 2023 when data collection was complete.
Lori, J., Kukula, V., Liu, L. et al. Improving health literacy through group antenatal care: results from a cluster randomized controlled trial in Ghana. BMC Pregnancy Childbirth 24, 37 (2024). https://doi.org/10.1186/s12884-023-06224-x
Therapeutic mechanisms of human neural stem cells (hNSCs) were studied in an Alzheimer's disease mouse model (5XFAD). hNSCs restored spatial memory abilities in 5XFAD animals; however, amyloid beta levels were unchanged. Spatial transcriptomics was used to probe mechanisms of hNSCs. Focusing on a subset of plaque-induced genes, gene normalization was seen particularly in microglia, confirmed by PROGENy and Cell Chat analyses. and The spatial transcriptomics data from this publication have been deposited in NCBI Gene Expression Omnibus (16) and are accessible through GEO Series accession number GSE209583 ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE209583 and enter token gzglogqkvjqrhmt). Additional supporting data are available from the corresponding author upon reasonable request.
Citation to related publication:
Chen KS, Noureldein MH, McGinley LM, Hayes JM, Rigan DM, Kwentus JF, Mason SN, Mendelson FE, Savelieffd MG, Feldman EL. Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism. bioRxiv [Preprint]. 2023 Nov 4:2023.11.01.565161. doi: 10.1101/2023.11.01.565161. PMID: 37961246; PMCID: PMC10635057.
Reconstructed CT slices for Incisor frag. of Plesiadapis gingerichi (University of Michigan Museum of Paleontology catalog number UMMP 68409) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
Reconstructed CT slices for Right M3/ of Plesiadapis gingerichi (University of Michigan Museum of Paleontology catalog number UMMP 68409) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
Reconstructed CT slices for Right M2/ of Plesiadapis gingerichi (University of Michigan Museum of Paleontology catalog number UMMP 68409) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
Reconstructed CT slices for Right maxilla with M1/ and roots of P4/ of Plesiadapis gingerichi (University of Michigan Museum of Paleontology catalog number UMMP 68409) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
The H2O concentration and H2O/Ce ratio in olivine-hosted melt inclusions are high (H2O up to 1410 ppm; H2O/Ce up to 77) in lunar sample 74220 but lower (H2O up to 430 ppm; H2O/Ce up to 9.4) in all other lunar samples studied before this work. This difference is absent for other volatiles (F, S, and Cl) in melt inclusions in 74220 and other lunar samples. Because H2O (or H) is a critical volatile component with significant ramifications on the origin and evolution of the Moon, it is important to understand what causes such a large gap in H2O/Ce ratio between 74220 and other lunar samples. Two explanations have been advanced. One is that volcanic product in sample 74220 has the highest cooling rate and thus best preserved H2O in melt inclusions compared to melt inclusions in other samples. The other explanation is that sample 74220 is a localized heterogeneity enriched in some volatiles. To distinguish the two possibilities, here we present new data from three rapidly cooled lunar samples: olivine-hosted glassy melt inclusions (OHMIs) in 74220 regolith and 79135 regolith breccia, and pyroxene-hosted glassy melt inclusions (PHMIs) in 15597 pigeonite basalts. If the gap is due to the difference in cooling rates, samples with cooling rates between 74220 and other studied lunar samples should have preserved intermediate H2O concentrations and H2O/Ce ratios. Our results show that melt inclusions in 79135 and 15597 contain high H2O concentrations (up to 969 ppm in 79135 and up to 793 ppm in 15597) and high H2O/Ce ratios (up to 21 in 79135 and up to 13 in 15997). Combined with literature data, we confirm that H2O/Ce ratios of different lunar samples are positively correlated to the cooling rates and independent of the type of mare basalts. Our work bridges the big gap in H2O/Ce ratio among 74220 and other lunar samples. We hence reinforce the interpretation that the lunar sample with the highest cooling rate best represents pre-eruptive volatiles in lunar basalts due to the least degassing. H2O, F, P, S and Cl concentrations in the lunar primitive mantle are also estimated in this work. and *** 2024-03-19: In addition to the files in the previous version, this updated deposit contains more data files as the supplementary files of the paper. For example, we added a summary excel file containing data that are used for figures in the paper, and an excel file contains data in the tables of the paper for easy use by readers. See ReadMe.txt for changes.
Reconstructed CT slices for Left dentary with P/4-M/1, M/2 trigonid, P/3 roots of Plesiadapis gingerichi (University of Michigan Museum of Paleontology catalog number UMMP 68409) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
This is a process evaluation of the RCT, Group Antenatal Care and Delivery project (GRAND) to identify and document patient, provider, and system barriers and facilitators to program implementation.
Using both quantitative and qualitative methods, potential and actual influences on the quality and conduct of the program's operations, implementation, and service delivery were identified.
Only the seven (7) sites randomized to the Group ANC (G-ANC) intervention were included for collection of process evaluation data since the evaluation was of G-ANC implementation.
Data were collected from August 2019 to November 2020 and included both quantitative and qualitative data sources.
Zielinski R, Kukula V, Apetorgbor V, Awini E, Moyer C, Badu-Gyan G, et al. (2023) “With group antenatal care, pregnant women know they are not alone”: The process evaluation of a group antenatal care intervention in Ghana. PLoS ONE 18(11): e0291855. https://doi.org/10.1371/journal.pone.0291855
Data consists largely of UV-VIs spectra, both raw and analyzed, that were used to calibrate the relevant sensor. A more detailed description of individual files' contents can be found in the ReadMe word document.