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- Creator:
- Wilson Mantilla, Jeffrey A.
- Description:
- Specimen RTMNU/DG/VERT/1/55P/2020 is a partial dentary of a small noasaurid dinosaur collected from Late Cretaceous sediments near the village of Pisdura, Maharashtra, India. The specimen was collected under the auspices of a Joint Collaborative Programme through a Memorandum of Understanding involving the Geological Survey of India (Government of India, Ministry of Mines) and the University of Michigan Museum of Palaeontology. The specimen is housed in the Department of Geology of Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur (Maharashtra) India. For access please contact Dhananjay Mohabey ( dinomohabey@yahoo.com) or Bandana Samant ( bandanabhu@gmail.com).
- Keyword:
- India, Dinosaur, Paleontology, Cretaceous, Maastrichtian, and Gondwana
- Citation to related publication:
- Mohabey, D. M., B. Samant, K. Vélez-Rosado, and J. A. Wilson Mantilla. (in press.) A review of small-bodied theropod dinosaurs from the Late Cretaceous of India, with description of new cranial remains of a noasaurid (Theropoda: Abelisauria). Journal of Vertebrate Paleontology. DOI:10.1080/02724634.2023.2288088
- Discipline:
- Science
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- Creator:
- Ye, Zhengwei and Mi, Zetian
- Description:
- Generation of C2+ compounds using sunlight, carbon dioxide, and water provides a promising path for carbon neutrality. The exploration of a catalyst to break the bottleneck of C-C coupling, for constructing a rational artificial photosynthesis integrated device, is at the core. Herein, based on operando spectroscopy measurements, theoretical calculations, and feedstock experiments, it is discovered that gold, in conjunction with iridium, can catalyze the reduction of CO2, achieving C-C coupling by insertion of CO2 into -CH3. Owing to a combination of optoelectronic and catalytic properties, the assembly of AuIr with InGaN nanowires on silicon (AuIr@InGaN NWs/Si) enables the achievement of a C2H6 activity of 58.8 mmol‧g-1‧h-1 with a turnover number of 54,595 over 60 hours. A light-to-fuels efficiency of ~0.59% for solar fuels production from CO2 and H2O is achieved without any other energy inputs. This work provides a carbon-negative path for producing higher order C compounds.
- Keyword:
- Carbon dioxide reduction and Photocatalysis
- Discipline:
- Science
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- Creator:
- Sorensen, Troy R, Espey, Eamon, Kelley, John G. W. , Kessler, James, and Gronewold, Andrew D.
- Description:
- Inland lakes play a critical role in ecosystem stability, and robust validation of lake models is essential for understanding their dynamics. While remote sensing data can assist with lake surface temperature validation, in situ data typically provides more accurate, reliable data not limited to only the lake surface. However, in situ temperature data for many individual lakes, particularly in North America, is difficult for researchers to quickly access in a standardized format. This database offers a well-organized collection of in situ near-surface and subsurface temperatures from 134 sites divided among 29 large North American inland lakes collected from a variety of sources. The database includes multiple subsurface temperatures throughout the depth profile of 84 of these sites, providing comprehensive data for lake model evaluation. All lakes selected for this database are large enough (over approximately 30 km^2 to be represented by large-scale operational weather models, supporting robust lake model validation efforts on the lakes that have the greatest impact on climatology.
- Keyword:
- lake, temperature, in situ, and subsurface
- Citation to related publication:
- Sorensen, T., Espey, E., Kelley, J.G.W. et al. A database of in situ water temperatures for large inland lakes across the coterminous United States. Sci Data 11, 282 (2024). https://doi.org/10.1038/s41597-024-03103-8
- Discipline:
- Science
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- Creator:
- Martin, Tara L, Young, LR, Goldsteen, D, Nunamaker, EA, Reynolds, P, Thompson-Iritani, S, Thurston, SE, and LaFollette, MR
- Description:
- This dataset contains the results of a survey of mouse handling methods by personnel working with laboratory mice. The survey included questions about preferred handling methods, barriers to use of refined handling methods, and a knowledge quiz about refined mouse handling. Data was collected via Qualtrics survey as described in the methodology section. This dataset is associated with the following publication, accepted by PLOS One: PONE-D-23-01633R1 Title: Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling Authors: Lauren Young, Donna Goldsteen, Elizabeth A. Nunamaker, Mark J. Prescott, Penny Reynolds, Sally Thompson-Iritani, Sarah E. Thurston, Tara L. Martin, Megan R. LaFollette
- Keyword:
- Mouse, Refined Handling, Tunnel Handling, Cup Handling, Laboratory Animal, and Animal Care
- Citation to related publication:
- Young LR, Goldsteen D, Nunamaker EA, Prescott MJ, Reynolds P, Thompson-Iritani S, Thurston SE, Martin TL, LaFollette MR. Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling. PLOS ONE. 2023. In Press.
- Discipline:
- Science
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- Creator:
- Ludlow, Andrew and Kim, Jeongjin
- Description:
- Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telomerase activity for physiological replacement of cells. Therefore, identifying differences in TERT regulation between stem cells and cancer cells is essential for developing telomerase inhibition-based cancer therapies that reduce damage to stem cells. In this study, we measured TERT splice variant expression and telomerase activity in induced pluripotent stem cells (iPSCs), neural progenitor cells (NPCs), and non-small cell lung cancer cells (NSCLC, Calu-6 cells). We observed that a NOVA1-PTBP1-PTBP2 axis regulates TERT alternative splicing (AS) in iPSCs and their differentiation into NPCs. We also found that splice-switching of TERT, which regulates telomerase activity, is induced by different cell densities in stem cells but not cancer cells. Lastly, we identified cell type-specific splicing factors that regulate TERT AS. Overall, our findings represent an important step forward in understanding the regulation of TERT AS in stem cells and cancer cells. These data and subsequent studies may reveal a splicing factor(s) or their binding site(s) that could be targeted with small molecule drugs or antisense oligonucleotides, respectively, to reduce telomerase activity in cancer cells and promote durable cancer remissions.
- Keyword:
- Telomere, telomerase, TERT, alternative RNA splicing
- Citation to related publication:
- Dynamics of TERT Regulation via Alternative Splicing in Stem Cells and Cancer Cells. Accepted in Plos One
- Discipline:
- Science
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- Creator:
- Srodawa, Kristy, Cerda, Peter A, Davis Rabosky, Alison R, and Crowe-Riddell, Jenna M
- Description:
- Snake venom research has historically focused on front-fanged species (Viperidae and Elapidae), limiting our knowledge of venom evolution in rear-fanged snakes across their ecologically-diverse phylogeny. Three finger toxins (3FTxs) are a known neurotoxic component in the venoms of some rear-fanged snakes (Colubrinae, Colubridae), but it is unclear how prevalent 3FTxs are both in expression within venom glands and more broadly among colubrine species. Here, we used a transcriptomic approach to characterize the venom expression profiles of four species of colubrine snakes from Neotropics that were dominated by 3FTx expression (in the genera Chironius, Oxybelis, Rhinobothryum, and Spilotes) and reconstructed the gene trees of 3FTxs. Overall, our results highlight the importance of exploring the venoms of understudied species in reconstructing the full evolutionary history of toxins across the tree of life.
- Keyword:
- snake venom, neurotoxin, molecular evolution, gene families, and opisthoglyphous
- Citation to related publication:
- Srodawa, K., Cerda, P.A., Davis Rabosky, A.R., Crowe-Riddell, J.M. Evolution of Three Finger Toxin Genes in Neotropical Colubrine Snakes (Colubridae). Toxins 2023, 15(9), 523; https://doi.org/10.3390/toxins15090523
- Discipline:
- Science
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- Creator:
- Dewey, Ryan M, Livi, Stefano, Lepri, Susan T, Raines, Jim M, Ploof, Keeling, and The HIS Science Team
- Description:
- The data contained within the archive are for analysis and replication of Figure 2 in Livi et al. (2023), First Results from the Solar Orbiter Heavy Ion Sensor, Astronomy & Astrophysics. The readme.txt file contains more details on the contents of the archive and its files. Livi et al. (2023) reports the first solar wind composition measurements collected from the Heavy Ion Sensor (HIS) on the Solar Orbiter spacecraft. The period of study spans January-June 2022 during with the spacecraft completed nearly a full orbit about the Sun, from 0.3 AU to 1.0 AU. The solar wind composition within this publication are the first within the inner heliosphere. This paper describes the data and its processing from raw measurements (e.g., the data contained within this archive) to derived composition data products, and examines these composition data products about an interplanetary shock and interplanetary coronal mass ejection. Finally, these composition data are examined statistically and compared to historical data sets.
- Keyword:
- Solar Orbiter, Solar wind, Heavy ions, and Heavy Ion Sensor
- Citation to related publication:
- Livi, S., et al. (2023), First Results from the Solar Orbiter Heavy Ion Sensor, Astronomy & Astrophysics. https://doi.org/10.1051/0004-6361/202346304 and Owen, C., et al. (2020), The Solar Orbiter Solar Wind Analyser (SWA) suite, Astronomy & Astrophysics, 642. https://doi.org/10.1051/0004-6361/201937259
- Discipline:
- Science
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- Creator:
- Thompson, Ellen P. and Ellis, Brian R.
- Description:
- Accurate prediction of physical alterations in carbonate reservoirs under dissolution is critical for development of subsurface energy technologies. The impact of mineral dissolution on flow characteristics depends on the connectivity and tortuosity of the pore network. Persistent homology is a tool from algebraic topology that describes the size and connectivity of topological features. When applied to 3D X-ray computed tomography (XCT) imagery of rock cores, it provides a novel metric of pore network heterogeneity. Prior works have demonstrated the efficacy of persistent homology in predicting flow properties in numerical simulations of flow through porous media. Its ability to combine size, spatial distribution, and connectivity information make it a promising tool for understanding reactive transport in complex pore networks, yet limited work has been done to apply persistence analysis to experimental studies on natural rocks. In this study, three limestone cores were imaged by XCT before and after acid-driven dissolution flow through experiments. Each XCT scan was analyzed using persistent homology. In all three rocks, permeability increase was driven by the growth of large, connected pore bodies. The two most homogenous samples saw an increased effect nearer to the flow inlet, suggesting emerging preferential flow paths as the reaction front progresses. The most heterogeneous sample showed an increase in along-core homogeneity during reaction. Variability of persistence showed moderate positive correlation with pore body size increase. Persistence heterogeneity analysis could be used to anticipate where greatest pore size evolution may occur in a reservoir targeted for subsurface development, improving confidence in project viability.
- Keyword:
- Carbonate dissolution, X-ray computed tomography, Porous media, Topology, and Persistent homology
- Citation to related publication:
- Thompson, E.P.; Ellis, B.R. (2023) Persistent Homology as a Heterogeneity Metric for Predicting Pore Size Change in Dissolving Carbonates. In Review.
- Discipline:
- Science and Engineering
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- Creator:
- University of Michigan Museum of Paleontology and CTEES
- Description:
- Reconstructed CT slices for navicular of Cantius trigonodus (University of Michigan Museum of Paleontology catalog number UMMP 87973) as a series of TIFF images. Raw projections are not included in this dataset. The reconstructed slice data from the scan are offered here as a series of unsigned 16-bit integer TIFF images. The upper left corner of the first image (*_0000.tif) is the XYZ origin.
- Keyword:
- Paleontology, Fossil, CT, Notharctidae, UMMP, University of Michigan Museum of Paleontology, Eocene, and a537f0d8-6185-9562-9b9a-a233468bf8e1
- Discipline:
- Science
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- Creator:
- Umaña, Maria, Swenson, Nathan G, and Arellano, Gabriel
- Description:
- Identifying the functional traits that enable recovery after extreme events is necessary for assessing forest persistence and functioning, yet this is a difficult task because the traits mediating the responses to disturbance may vary depending on the disturbance type and over time. This study investigates the effects of traits on tree growth –for short and longer terms– in response to two vastly different extreme climatic events, droughts, and hurricanes, in a Puerto Rican forest.
- Keyword:
- Tropical tree, relative growth rates , and Puerto Rico
- Citation to related publication:
- Umaña, M. N. In review. The interplay of drought and hurricanes on tree recovery: insights from dynamic and weak functional responses. Forthcoming and Umana, M. (2023). Functional trait data across an elevational gradient of six tree species in El Yunque National Park, Puerto Rico in 2015 [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/7962-4t98
- Discipline:
- Science