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- Creator:
- Li, Yang and Steiner, Allison
- Description:
- WRF-Chem simulation with 1.33 km resolution using the MYJ PBL scheme over the Baltimore-Washington region and WRF-Chem simulation with 1.33 km resolution using the YSU PBL scheme over the Baltimore-Washington region
- Keyword:
- LES, WRF-Chem, vertical mixing, oxidants, boundary layer dynamics
- Citation to related publication:
- Li, Y., Barth, M. C., and Steiner, A. L.: Comparing turbulent mixing of atmospheric oxidants across model scales, Atmospheric Environment, 199, 88-101, https://doi.org/10.1016/j.atmosenv.2018.11.004, 2018.
- Discipline:
- Science
- Title:
- Comparing turbulent mixing of atmospheric oxidants across model scales
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- Creator:
- Liu, Y , Ettinger, AS, Téllez-Rojo, M, Sánchez, BN, Zhang, ZZ, Cantoral, A, and Hu, H
- Description:
- We used data collected from participants of the Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) study, which consists of three sequentially-enrolled birth cohorts of pregnant women. Research protocols of this study were approved by the Institutional Review Board at University of Michigan and the Mexico National Institute of Public Health. We obtained informed consent from mothers and informed assent from children prior to enrollment.
- Discipline:
- Health Sciences
- Title:
- Prenatal lead exposure, type 2 diabetes and cardiometabolic risk factors in Mexican children at age 10-18 years
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- Creator:
- Tronson, Natalie C and Tchessalova, Daria
- Description:
- The main goal of this research was to identify potential molecular pathways that contribute to memory dysregulation and decline that persists long after illness or inflammation. We have previously established a subchronic immune challenge model that results in memory impairments months after the inflammatory challenge. This project aimed to determine whether memory impairments were accompanied by transcriptional dysregulation in memory related brain region (the hippocampus). These data show the differential gene expression as log2fold change (and p-value) in males and females 3 months after immune challenge (Supp Tables 1 and 2); after a subsequent immune challenge (Supp Tables 3 and 4); the differential regulation of genes in males and females (Supp Table 5); genes differentially expressed in the hippocampus of males and females at baseline (Supp Table 6) and the differential regulation of those genes in males and females after immune challenge (Supp Tables 7,8).
- Keyword:
- hippocampus, lipopolysaccharide, differential gene expression, RNA sequencing, neuroimmune, sex differences, learning and memory, and inflammation
- Citation to related publication:
- Tchessalova, D., & Tronson, N. C. (2019). Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge. BioRxiv, 566570. https://doi.org/10.1101/566570
- Discipline:
- Science and Health Sciences
- Title:
- Supplemental Data for "Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge"
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- Creator:
- Hodgins-Davis, Andrea, Duveau, Fabien, Walker, Elizabeth, and Wittkopp, Patricia J
- Description:
- Understanding how phenotypes evolve requires disentangling the effects of mutation generating new variation from the effects of selection filtering it. Tests for selection frequently assume that mutation introduces phenotypic variation symmetrically around the population mean, yet few studies have tested this assumption by deeply sampling the distributions of mutational effects for particular traits. Here, we examine distributions of mutational effects for gene expression in the budding yeast Saccharomyces cerevisiae by measuring the effects of thousands of point mutations introduced randomly throughout the genome. We find that the distributions of mutational effects differ for the ten genes surveyed and are inconsistent with normality. For example, all ten distributions of mutational effects included more mutations with large effects than expected for normally distributed phenotypes. In addition, some genes also showed asymmetries in their distribution of mutational effects, with new mutations more likely to increase than decrease the gene’s expression or vice versa. Neutral models of regulatory evolution that take these empirically determined distributions into account suggest that neutral processes may explain more expression variation within natural populations than currently appreciated.
- Keyword:
- gene expression, evolution, mutation, mutagenesis, regulatory evolution, YFP, reporter construct, yeast, TDH1, TDH2, TDH3, GPD1, OST1, PFY1, STM1, RNR1, and RNR2
- Citation to related publication:
- Hodgins-Davis, A., Duveau, F., Walker, E. A., & Wittkopp, P. J. (2019). Empirical measures of mutational effects define neutral models of regulatory evolution in Saccharomyces cerevisiae. BioRxiv, 551804. https://doi.org/10.1101/551804
- Discipline:
- Science
- Title:
- Dataset for "Empirical measures of mutational effects define neutral models of regulatory evolution in Saccharomyces cerevisiae"
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- Creator:
- Schiffmann, Philipp, Sick, Volker, and Reuss, David L
- Description:
- This archive contains data files from motored internal combustion engine experiments. Included are two-dimensional two-component velocity fields from four measurement planes with maximized field of view. in-cylinder pressure measurements, external pressure and temperature data, as well as details on the geometry of the optical engine to enable setups of simulation configurations. Motored operating conditions include 40kPa and 90kPa MAP, 800 and 1300 RPM.
- Keyword:
- TCC III engine, internal combustion engine, particle image velocimetry, in-cylinder flow, turbulence in engines, CFD validation data, motored engine, optical engine, cyclic variability , and PIV
- Citation to related publication:
- http://dx.doi.org/10.2516/ogst/2015028
- Discipline:
- Engineering
- Title:
- TCCIII Motored Full View
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- Creator:
- Schiffmann, Philipp, Sick, Volker, and Reuss, David L
- Description:
- This archive contains data files from spark-ignited homogenous combustion internal combustion engine experiments. Included are two-dimensional two-component velocity fields acquired in a small, high-resolution field of view near the spark plug, and images of hydroxyl radical chemiluminescence recording the early flame-kernel growth. Included are in-cylinder pressure measurements, external pressure and temperature data, as well as details on the geometry of the optical engine to enable setups of simulation configurations. Included are tables of one-per-cycle parameters for each test with methane or propane at stoichiometric, dilute limit, lean limit, and rich limit, operation conducted at 40kPa and 1300 RPM.
- Keyword:
- OH* imaging, TCC III engine, internal combustion engine, particle image velocimetry, in-cylinder flow, turbulence in engines, CFD validation data, cyclic variability, early flame kernel growth, optical engine, combustion variability, ignition, and PIV
- Citation to related publication:
- dx.doi.org/10.1177/1468087417720558
- Discipline:
- Engineering
- Title:
- TCCIII Fired Spark Plug Region
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- Creator:
- Schiffmann, Philipp, Sick, Volker, and Reuss, David L
- Description:
- This archive contains data files from spark-ignited homogenous combustion internal combustion engine experiments. Included are two-dimensional two-component velocity fields from various measurement planes with maximized field of view, in-cylinder pressure measurements, external pressure and temperature data, as well as details on the geometry of the optical engine to enable setups of simulation configurations. Fired operation was with stoichiometric propane air, 40kPa MAP, at 1300 RPM.
- Keyword:
- TCC III engine, internal combustion engine, particle image velocimetry, in-cylinder flow, turbulence in engines, CFD validation data, cyclic variability, optical engine, combustion variability, and PIV
- Citation to related publication:
- dx.doi.org/10.1177/1468087417720558
- Discipline:
- Engineering
- Title:
- TCCIII Fired Full View
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- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- translation/translation to appear.
- Citation to related publication:
- Discipline:
- Humanities
- Title:
- Bangime audio 2015 text 04 Hunters part 1
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- Creator:
- Meurer, William J., Meka, Arjun, and Porath, Jon
- Description:
- Introduction: Diagnostic testing is common in the emergency department. The value of some testing is questionable. The purpose of this study was to assess how varying levels of benefit, risk, and costs influenced an individual’s desire to have diagnostic testing. Methods: A survey through Amazon Mechanical Turk presented hypothetical clinical situations: low risk chest pain and minor traumatic brain injury. Each scenario included three given variables (benefit, risk, and cost), that was independently randomly varied over four possible values (0.1%, 1%, 5%, 10% for benefit and risk and $0, $100, $500, and $1000 for the individual’s personal cost for receiving the test). Benefit was defined as the probability of finding the target disease (traumatic intracranial hemorrhage or acute coronary syndrome). Results: A total of 1000 unique respondents completed the survey. Increasing benefit from 0.1% to 10%, the percent of respondents who accepted a diagnostic test went from 28.4% to 53.1%. [OR: 3.42 (2.57-4.54)] As risk increased from 0.1% to 10%, this number decreased from 52.5% to 28.5%. [OR: 0.33 (0.25-0.44)] Increasing cost from $0 to $1000 had the greatest change of those accepting the test from 61.1% to 21.4%, respectively. [OR: 0.15 (0.11-0.2)] Conclusions: The desire for testing was strongly sensitive to the benefits, risks and costs. Many participants wanted a test when there was no added cost, regardless of benefit or risk levels, but far fewer elected to receive the test as cost increased incrementally. This suggests that out of pocket costs may deter patients from undergoing diagnostic testing with low potential benefit.
- Citation to related publication:
- Discipline:
- Health Sciences
- Title:
- mTURK diagnostic testing dataset May 2015
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- Creator:
- Meurer, William
- Description:
- Dataset for analysis in SPSS
- Citation to related publication:
- Discipline:
- Health Sciences
- Title:
- Optimizing Communication of Emergency Response Adaptive Randomization Clinical Trials to Potential Participants