Work Description

Title: Carbamazepine and GABA have distinct effects on seizure onset dynamics in mouse brain slices Open Access Deposited

http://creativecommons.org/publicdomain/zero/1.0/
Attribute Value
Methodology
  • Epileptiform activity was generated from mouse brain slices using a low Mg 2+ /high K + (LMHK) seizure model. Three experimental conditions were applied: LMHK (control), LMHK+GABA, and LMHK + Carbamazepine. Three reviewers independently labeled all onset dynamics of the epileptiform activity. The onset dynamics were compared to experimental conditions. Other statistical tests were performed to validate inter-rater variability and drug efficacy.
Description
  • This data and scripts are meant to test and show that seizure onset dynamics can be modulated using anti-epileptic drugs. A zip file is included that contains all waveform data, MATLAB processing scripts, and metadata. The MATLAB scripts allow for visual review validation and objective feature analysis. The file includes various README files explaining the scripts and their relationships in greater detail.
Creator
Depositor
  • dncrisp@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
ORSP grant number
  • AWD002118
Keyword
Date coverage
  • 2016-01-01 to 2019-12-31
Resource type
Last modified
  • 07/06/2020
Published
  • 07/06/2020
Language
DOI
  • https://doi.org/10.7302/ntwz-s054
License
To Cite this Work:
Crisp, D., Parent, R., Nakatani, M., Murphy, G., Stacey, W. Carbamazepine and GABA have distinct effects on seizure onset dynamics in mouse brain slices [Data set], (2020). University of Michigan - Deep Blue. https://doi.org/10.7302/ntwz-s054

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