Work Description

Title: Dataset for D1 and D2 Comparisons in Mouse Self-Stimulation Open Access Deposited
Attribute Value
  • Two independent self-stimulation procedures were used to allow mice to earn brief NAc laser stimulations as a reward. First, a spout-touch self-stimulation procedure allowed mice to earn brief 1-sec laser pulses in NAc each time they touched a particular metal spout (which we will call laser-spout) that protruded into the chamber. Another spout was also present, but earned nothing when touched, and served as a control stimulus for comparison. Second, a separate place-based self-stimulation task allowed mice to earn series of laser pulses by entering a particular corner of a 4-corner chamber and remaining there; this task was based on the original Olds and Milner procedure that discovered deep brain self-stimulation when a rat went to a particular location to activate its electrode. After the location task, some mice were also retested on the spout task to reconfirm their initial results.
  • The nucleus accumbens (NAc) contains multiple subpopulations of medium spiny neurons (MSNs): one subpopulation expresses D1-type dopamine receptors, another expresses D2-type receptors, and a third expresses both. The relative roles in NAc of D1 neurons versus D2 neurons in appetitive motivation were assessed here. Specifically, we asked whether D1-Cre mice or D2-Cre mice would instrumentally seek optogenetic self-stimulation of those respective subpopulations in NAc, or instead avoid NAc laser stimulation.

  • Some statistical forms have been exported from SPSS for the purposes of accessibility to viewers. Please see the "readme" text for descriptions of each individual excel file.
Contact information
Funding agency
  • National Institutes of Health (NIH)
Citations to related material
Resource type
Last modified
  • 11/05/2019
  • 04/04/2018
To Cite this Work:
Cole, S. (2018). Dataset for D1 and D2 Comparisons in Mouse Self-Stimulation [Data set]. University of Michigan - Deep Blue.


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