Work Description

Title: Dataset for D1 and D2 Comparisons in Mouse Self-Stimulation Open Access Deposited

http://creativecommons.org/licenses/by-nc/4.0/
Attribute Value
Methodology
  • Two independent self-stimulation procedures were used to allow mice to earn brief NAc laser stimulations as a reward. First, a spout-touch self-stimulation procedure allowed mice to earn brief 1-sec laser pulses in NAc each time they touched a particular metal spout (which we will call laser-spout) that protruded into the chamber. Another spout was also present, but earned nothing when touched, and served as a control stimulus for comparison. Second, a separate place-based self-stimulation task allowed mice to earn series of laser pulses by entering a particular corner of a 4-corner chamber and remaining there; this task was based on the original Olds and Milner procedure that discovered deep brain self-stimulation when a rat went to a particular location to activate its electrode. After the location task, some mice were also retested on the spout task to reconfirm their initial results.
Description
  • The nucleus accumbens (NAc) contains multiple subpopulations of medium spiny neurons (MSNs): one subpopulation expresses D1-type dopamine receptors, another expresses D2-type receptors, and a third expresses both. The relative roles in NAc of D1 neurons versus D2 neurons in appetitive motivation were assessed here. Specifically, we asked whether D1-Cre mice or D2-Cre mice would instrumentally seek optogenetic self-stimulation of those respective subpopulations in NAc, or instead avoid NAc laser stimulation.

  • Some statistical forms have been exported from SPSS for the purposes of accessibility to viewers. Please see the "readme" text for descriptions of each individual excel file.
Creator
Depositor
  • shinok@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
Keyword
Date coverage
  • 2012-10-15 to 2017-10-30
Citations to related material
Resource type
Last modified
  • 11/14/2018
Published
  • 04/04/2018
Language
DOI
License
To Cite this Work:
Cole, S. (2018). Dataset for D1 and D2 Comparisons in Mouse Self-Stimulation [Data set]. University of Michigan - Deep Blue. https://doi.org/10.7302/Z2N014RK

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