Work Description

Title: Action current data for investigating the development and organization of GnRH neuron activity in mice. Open Access Deposited

http://creativecommons.org/licenses/by/4.0/
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Methodology
  • Action currents, which are associated with action potential firing, were recorded from GFP-identified neurons in acutely-prepared brain slices from control and PNA female mice at three weeks of age and adults. These events were detected, confirmed, and later analyzed with custom software written in Igor Pro. For more specific details on the data acquisition process, please refer to the following: Dulka EA, Moenter SM. Prepubertal development of gonadotropin-releasing hormone (GnRH) neuron activity is altered by sex, age and prenatal androgen exposure. Endocrinology 2017; 158:3941-3953
Description
  • This data is a subset of that originally produced as part of an effort to characterize GnRH neuron activity during prepubertal development in control and PNA mice and investigate the potential influences of sex and PNA treatment on this process (1). It was later used in (2) to further investigate the firing patterns of GnRH neurons in these categories of mice and determine how these patterns might differ based on age and treatment condition. The data files can be opened and examined using Wavemetric's Igor Pro software. Code used to further examine and visualize the data can be found at  https://gitlab.com/um-mip/mc-project-code. This research was supported by National Institute of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development R01 HD34860 and P50 HD28934. (1) Dulka EA, Moenter SM. Prepubertal development of gonadotropin-releasing hormone (GnRH) neuron activity is altered by sex, age and prenatal androgen exposure. Endocrinology 2017; 158:3941-3953 (2) Penix JJ, DeFazio RA, Dulka EA, Schnell S, Moenter SM. Firing patterns of gonadotropin-releasing hormone (GnRH) neurons are sculpted by their biology. Pending.
Creator
Depositor
  • jonpenix@umich.edu
Contact information
Discipline
Funding agency
  • National Institutes of Health (NIH)
  • Other Funding Agency
Other Funding agency
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
ORSP grant number
  • 13-PAF06664, 17-PAF02492
Keyword
Date coverage
  • 2014-06-18 to 2017-04-24
Citations to related material
  • Dulka EA, Moenter SM. Prepubertal development of gonadotropin-releasing hormone (GnRH) neuron activity is altered by sex, age and prenatal androgen exposure. Endocrinology 2017; 158:3941-3953 Penix JJ, DeFazio RA, Dulka EA, Schnell S, Moenter SM. Firing patterns of gonadotropin-releasing hormone (GnRH) neurons are sculpted by their biology. Pending.
Resource type
Last modified
  • 09/17/2019
Published
  • 09/17/2019
Language
License
To Cite this Work:
Dulka, E. (2019). Action current data for investigating the development and organization of GnRH neuron activity in mice [Data set]. University of Michigan - Deep Blue.

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