Work Description

Title: Low-THz Vibrations of Biological Membranes Open Access Deposited

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Attribute Value
Methodology
  • Molecular dynamics simulations, Python analysis, Kolmogrov-Smirnov statistics, and graph theory were used to collect and process the data included in this work.
Description
  • A growing body of work has linked key biological activities to the mechanical properties of cellular membranes, and as a means of identification. Here, we present a computational approach to simulate and compare the vibrational spectra in the low-THz region for mammalian and bacterial membranes, investigating the effect of membrane asymmetry and composition, as well as the conserved frequencies of a specific cell. We find that asymmetry does not impact the vibrational spectra, and the impact of sterols depends on the mobility of the components of the membrane. We demonstrate that vibrational spectra can be used to distinguish between membranes and, therefore, could be used in identification of different organisms. The method presented, here, can be immediately extended to other biological structures (e.g., amyloid fibers, polysaccharides, and protein-ligand structures) in order to fingerprint and understand vibrations of numerous biologically-relevant nanoscale structures.
Creator
Depositor
  • cluyet@umich.edu
Contact information
Discipline
Funding agency
  • Other Funding Agency
  • Department of Defense (DOD)
Other Funding agency
  • BlueSky Initiative, University of Michigan
ORSP grant number
  • HR00111720067
Keyword
Date coverage
  • 2021-01-01 to 2023-01-03
Citations to related material
Related items in Deep Blue Documents
Resource type
Curation notes
  • This data set was moved from Deep Blue Documents to Deep Blue Data on August 9, 2023. The original DOI in Deep Blue Documents is still active and the landing page in that repository will direct users to this page in Deep Blue Data.
Last modified
  • 08/22/2023
Published
  • 08/22/2023
Language
DOI
  • https://doi.org/10.7302/6571
License
To Cite this Work:
Luyet, C., Elvati, P., Vinh, J., Violi, A. (2023). Low-THz Vibrations of Biological Membranes [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/6571

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Files (Count: 2; Size: 222 MB)

Thumbnailthumbnail-column Title Original Upload Last Modified File Size Access Actions
README_MEMBRANES 2023-08-09 2023-08-09 29.9 KB Open Access
DBD_Rev_Luyet_LowThzVib.zip 2023-08-10 2023-08-10 222 MB Open Access

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