<1001. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27177706
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Marrocco-Trischitta MM
AU  - Mazzone P
AU  - Vitale R
AU  - Regazzoli D
AU  - Laricchia A
AU  - Chiesa R
FA  - Marrocco-Trischitta, Massimiliano M
FA  - Mazzone, Patrizio
FA  - Vitale, Renato
FA  - Regazzoli, Damiano
FA  - Laricchia, Alessandra
FA  - Chiesa, Roberto
IN  - Marrocco-Trischitta,Massimiliano M. Cardiothoracic and Vascular Department, Vascular Surgery Unit, IRCCS Ospedale San Raffaele, Milano, Italy. Electronic address: max_marrocco@yahoo.com.
IN  - Mazzone,Patrizio. Cardiothoracic and Vascular Department, Arrhythmology and Cardiac Pacing Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
IN  - Vitale,Renato. Cardiothoracic and Vascular Department, Vascular Surgery Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
IN  - Regazzoli,Damiano. Cardiothoracic and Vascular Department, Arrhythmology and Cardiac Pacing Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
IN  - Laricchia,Alessandra. Cardiothoracic and Vascular Department, Cardiology Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
IN  - Chiesa,Roberto. Cardiothoracic and Vascular Department, Vascular Surgery Unit, IRCCS Ospedale San Raffaele, Milano, Italy; Cardiothoracic and Vascular Department, IRCCS Ospedale San Raffaele, Universita Vita-Salute San Raffaele, Milano, Italy.
TI  - Temporary Transvenous Pacemaker Implantation during Carotid Endarterectomy in Patients with Trifascicular Block.
SO  - Annals of Vascular Surgery. 34:206-11, 2016 Jul.
AS  - Ann Vasc Surg. 34:206-11, 2016 Jul.
NJ  - Annals of vascular surgery
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - avs, 8703941
SB  - Index Medicus
CP  - Netherlands
AB  - BACKGROUND: The risk of severe perioperative bradyarrhythmias in patients with chronic left bundle branch, or bifascicular block, and an additional first-degree atrioventricular block undergoing carotid endarterectomy (CEA) has never been specifically addressed. In this study, we aimed to investigate whether these conduction abnormalities entail an increased risk of hemodynamic compromise during CEA and the role of temporary transvenous pacemaker (TTVPM) implantation as a prophylactic measure in this subgroup of patients.
AB  - METHODS: Between June 2006 and June 2013, 37 CEAs were performed in 31 patients (29 men, mean age 76 +/- 6 years), in whom a TTVPM was implanted for a trifascicular block. Thirty-seven concurrent, consecutive patients operated for other vascular pathologies also with a prophylactic TTVPM for an asymptomatic trifascicular block served as controls. Adverse events were considered: pacemaker activation, block progression, bradycardia <40 beats/min, and asystole.
AB  - RESULTS: Study and control groups were overall comparable. No perioperative mortality was recorded. All patients undergoing CEA were asymptomatic for syncope preoperatively. Among them, in 34 cases, indication for TTVPM was based on preoperative EKG, and in 4, a pacemaker activation was recorded. Three additional patients were also included in the study group in whom TTVPM was implanted due to the occurrence of adverse advents, and not prophylactically. In 2 of these, severe bradycardia with eventual asystole occurred intraoperatively. In both cases, the procedure was discontinued and rescheduled for the following day after a TTVPM was implanted. In the last additional case, the patient had a block progression on day 1 after an uneventful CEA and was emergently treated with a TTVPM. Overall, 7 adverse events were recorded in the study group, and none in the control group (P < 0.011). Morbidity in the CEA group also included 1 myocardial infarction, 1 minor stroke, 1 surgical revision for cervical hematoma, 1 new-onset atrial fibrillation, and 1 femoral artery pseudoaneurysm.
AB  - CONCLUSIONS: In our experience, TTVPM implantation was a clinically useful adjunct in patients with trifascicular block submitted to CEA, as compared with other vascular surgical procedures. However, the risks inherent to CEA in this subgroup of patients suggest that surgical treatment may not be warranted for those with asymptomatic carotid disease.Copyright © 2016 Elsevier Inc. All rights reserved.
ES  - 1615-5947
IL  - 0890-5096
DI  - S0890-5096(16)30230-8
DO  - http://dx.doi.org/10.1016/j.avsg.2015.12.025
PT  - Journal Article
LG  - English
EP  - 20160510
DP  - 2016 Jul
DC  - 20160702
YR  - 2016
UP  - 20160705
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27177706

<1002. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27361539
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Melo X
AU  - Abreu A
AU  - Santos V
AU  - Cunha P
AU  - Oliveira M
AU  - Pinto R
AU  - Carmo MM
AU  - Ferreira R
AU  - Fernhall B
AU  - Santa-Clara H
FA  - Melo, Xavier
FA  - Abreu, Ana
FA  - Santos, Vanessa
FA  - Cunha, Pedro
FA  - Oliveira, Mario
FA  - Pinto, Rita
FA  - Carmo, Miguel Mota
FA  - Ferreira, Rui
FA  - Fernhall, Bo
FA  - Santa-Clara, Helena
IN  - Melo,Xavier. 1Faculty Human Kinetics - University of Lisbon, Lisbon, Portugal. 2Santa Marta Hospital, Lisbon, Portugal. 3College of Applied Health Sciences - University of Illinois at Chicago, Chicago, IL.
TI  - Response To Exercise Training In Cardiac Resynchronization Therapy Patients With Atrial Fibrillation Versus Sinus Rhythm.: 2970 Board #35 June 3, 3: 30 PM - 5: 00 PM.
SO  - Medicine & Science in Sports & Exercise. 48(5 Suppl 1):836, 2016 May.
AS  - Med Sci Sports Exerc. 48(5 Suppl 1):836, 2016 May.
NJ  - Medicine and science in sports and exercise
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - 8005433, mg8
SB  - Index Medicus
CP  - United States
ES  - 1530-0315
IL  - 0195-9131
DO  - http://dx.doi.org/10.1249/01.mss.0000487505.26060.eb
PT  - Journal Article
LG  - English
DP  - 2016 May
DC  - 20160701
YR  - 2016
UP  - 20160705
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27361539

<1003. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26169326
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Barrios V
AU  - Escobar C
AU  - Prieto L
AU  - Osorio G
AU  - Polo J
AU  - Lobos JM
AU  - Vargas D
AU  - Garcia N
FA  - Barrios, Vivencio
FA  - Escobar, Carlos
FA  - Prieto, Luis
FA  - Osorio, Genoveva
FA  - Polo, Jose
FA  - Lobos, Jose Maria
FA  - Vargas, Diego
FA  - Garcia, Nicolas
IN  - Barrios,Vivencio. Servicio de Cardiologia, Hospital Universitario Ramon y Cajal, Madrid, Spain. Electronic address: vivencio.barrios@gmail.com.
IN  - Escobar,Carlos. Servicio de Cardiologia, Hospital Universitario La Paz, Madrid, Spain.
IN  - Prieto,Luis. Bioestadistica Medica, Universidad Catolica San Antonio de Murcia (UCAM), Murcia, Spain.
IN  - Osorio,Genoveva. Departamento Medico, Bayer Hispania S.L., Barcelona, Spain.
IN  - Polo,Jose. Centro de Salud Casar de Caceres, Casar de Caceres, Caceres, Spain.
IN  - Lobos,Jose Maria. Centro de Salud Jazmin, Area 4 de Atencion Primaria, Madrid, Spain.
IN  - Vargas,Diego. Unidad de Hospitalizacion Polivalente, Hospital de Alta Resolucion El Toyo, Hospital de Poniente El Ejido, Almeria, Spain.
IN  - Garcia,Nicolas. Departamento Medico, Bayer Hispania S.L., Barcelona, Spain.
TI  - Anticoagulation Control in Patients With Nonvalvular Atrial Fibrillation Attended at Primary Care Centers in Spain: The PAULA Study.
CM  - Comment in: Rev Esp Cardiol (Engl Ed). 2016 Mar;69(3):355; PMID: 26838060
CM  - Comment in: Rev Esp Cardiol (Engl Ed). 2016 Mar;69(3):356-7; PMID: 26838057
CM  - Comment in: Rev Esp Cardiol (Engl Ed). 2015 Sep;68(9):740-2; PMID: 26209249
SO  - Revista Espanola de Cardiologia. 68(9):769-76, 2015 Sep.
AS  - Rev Esp Cardiol (Engl). 68(9):769-76, 2015 Sep.
NJ  - Revista espanola de cardiologia (English ed.)
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101587954
SB  - Index Medicus
CP  - Spain
KW  - Antagonistas de la vitamina K;  Control de la razon internacional normalizada;  Fibrilacion auricular no valvular;  International normalized ratio control;  Nonvalvular atrial fibrillation;  Rosendaal;  Vitamin K antagonists
AB  - INTRODUCTION AND OBJECTIVES: To determine the current status of anticoagulation control in patients with nonvalvular atrial fibrillation treated with vitamin K antagonists in the primary care setting in Spain.
AB  - METHODS: The PAULA study was a multicenter cross-sectional/retrospective observational study conducted throughout Spain. The study included patients with nonvalvular atrial fibrillation who had been receiving vitamin K antagonist therapy during the past year and were attended at primary care centers. International normalized ratio (INR) values over the past 12 months were recorded. The degree of anticoagulation control was defined as the time the patient had remained within the therapeutic range and was determined by both the direct method (poor control < 60%) and by the Rosendaal method (poor control < 65%).
AB  - RESULTS: The study assessed 1524 patients (mean age, 77.4 +/- 8.7 years; 48.6% women; 64.2% in permanent atrial fibrillation; CHADS2 mean, 2.3 +/- 1.2; CHA2DS2-VASc, 3.9 +/- 1.5, and HAS-BLED, 1.6 +/- 0.9). The mean number of INR readings recorded per patient was 14.4 +/- 3.8. A total of 56.9% of patients had adequate INR control according to the direct method and 60.6% according to the Rosendaal method. The multivariate analysis identified the following predictors for poor INR control: female sex, dietary habits potentially affecting anticoagulation with vitamin K antagonists, multidrug therapy, and a history of labile INR.
AB  - CONCLUSIONS: Approximately 40% of patients (43.1% by the direct method and 39.4% by the Rosendaal method) with nonvalvular atrial fibrillation who were receiving anticoagulation therapy with vitamin K antagonists in primary care in Spain had poor anticoagulation control during the previous 12 months.Copyright © 2015 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
ES  - 1885-5857
IL  - 1885-5857
DI  - S1885-5857(15)00234-0
DO  - http://dx.doi.org/10.1016/j.rec.2015.04.017
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20150711
DP  - 2015 Sep
DC  - 20150831
YR  - 2015
UP  - 20160630
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26169326

<1004. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26743070
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Krause U
AU  - Backhoff D
AU  - Klehs S
AU  - Schneider HE
AU  - Paul T
FA  - Krause, Ulrich
FA  - Backhoff, David
FA  - Klehs, Sophia
FA  - Schneider, Heike E
FA  - Paul, Thomas
IN  - Krause,Ulrich. Department of Pediatric Cardiology and Intensive Care Medicine, University Medical Center, Gottingen, Germany. ukrause1@gwdg.de.
IN  - Backhoff,David. Department of Pediatric Cardiology and Intensive Care Medicine, University Medical Center, Gottingen, Germany.
IN  - Klehs,Sophia. Department of Pediatric Cardiology and Intensive Care Medicine, University Medical Center, Gottingen, Germany.
IN  - Schneider,Heike E. Department of Pediatric Cardiology and Intensive Care Medicine, University Medical Center, Gottingen, Germany.
IN  - Paul,Thomas. Department of Pediatric Cardiology and Intensive Care Medicine, University Medical Center, Gottingen, Germany.
TI  - Contact force monitoring during catheter ablation of intraatrial reentrant tachycardia in patients with congenital heart disease.
SO  - Journal of Interventional Cardiac Electrophysiology. 46(2):191-8, 2016 Aug.
AS  - J Interv Card Electrophysiol. 46(2):191-8, 2016 Aug.
NJ  - Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - c8k, 9708966
SB  - Index Medicus
CP  - Netherlands
KW  - Catheter ablation;  Congenital heart disease;  Contact force monitoring;  Intraatrial reentrant tachycardia
AB  - BACKGROUND: Monitoring of catheter contact force during catheter ablation of atrial fibrillation has been shown to increase efficacy and safety. However, almost no data exists on the use of this technology in catheter ablation of intraatrial reentrant tachycardia in patients with congenital heart disease. The aim of the present study was to evaluate the impact of contact force monitoring during catheter ablation of intraatrial reentrant tachycardia in those patients.
AB  - METHODS: Catheter ablation of intraatrial reentrant tachycardia using monitoring of catheter contact force was performed in 28 patients with congenital heart disease (CHD). Thirty-two patients matched according to gender, age, and body weight with congenital heart disease undergoing catheter ablation without contact force monitoring served as control group. Parameters reflecting acute procedural success, long-term efficacy, and safety were compared.
AB  - RESULTS: Acute procedural success was statistically not different in both groups (contact force 93 % vs. control 84 %, p=0.3). Likewise the recurrence rate 1 year after ablation as shown by Kaplan-Meier analysis did not differ (contact force 28 % vs. control 37 %, p=0.63). Major complications were restricted to groin vessel injuries and occurred in 3 out of 60 patients (contact force n=1; control n=2). Complications related to excessive catheter contact force were not observed.
AB  - CONCLUSION: The present study did not show superiority of catheter contact force monitoring during ablation of intraatrial reentrant tachycardia in patients with CHD in terms of efficacy and safety. Higher contact force compared to pulmonary vein isolation might therefore be required to increase the efficacy of catheter ablation of intraatrial reentrant tachycardia in patients with congenital heart disease.
ES  - 1572-8595
IL  - 1383-875X
DO  - http://dx.doi.org/10.1007/s10840-015-0096-z
PT  - Journal Article
LG  - English
EP  - 20160107
DP  - 2016 Aug
DC  - 20160628
YR  - 2016
UP  - 20160629
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26743070

<1005. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27142292
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Horjen AW
AU  - Ulimoen SR
AU  - Enger S
AU  - Norseth J
AU  - Seljeflot I
AU  - Arnesen H
AU  - Tveit A
FA  - Horjen, Anja Wiedswang
FA  - Ulimoen, Sara Reinvik
FA  - Enger, Steve
FA  - Norseth, Jon
FA  - Seljeflot, Ingebjorg
FA  - Arnesen, Harald
FA  - Tveit, Arnljot
IN  - Horjen,Anja Wiedswang. Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, N-3004, Drammen, Norway. awhorjen@gmail.com.
IN  - Horjen,Anja Wiedswang. Faculty of Medicine, University of Oslo, Oslo, Norway. awhorjen@gmail.com.
IN  - Ulimoen,Sara Reinvik. Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, N-3004, Drammen, Norway.
IN  - Enger,Steve. Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, N-3004, Drammen, Norway.
IN  - Norseth,Jon. Clinic for Medical Diagnostics, Vestre Viken Hospital Trust, Drammen, Norway.
IN  - Seljeflot,Ingebjorg. Faculty of Medicine, University of Oslo, Oslo, Norway.
IN  - Seljeflot,Ingebjorg. Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway.
IN  - Arnesen,Harald. Faculty of Medicine, University of Oslo, Oslo, Norway.
IN  - Arnesen,Harald. Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway.
IN  - Tveit,Arnljot. Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, N-3004, Drammen, Norway.
TI  - Troponin I levels in permanent atrial fibrillation-impact of rate control and exercise testing.
SO  - BMC Cardiovascular Disorders. 16:79, 2016.
AS  - BMC Cardiovasc Disord. 16:79, 2016.
NJ  - BMC cardiovascular disorders
PI  - Journal available in: Electronic
PI  - Citation processed from: Internet
JC  - 100968539
OI  - Source: NLM. PMC4855853
SB  - Index Medicus
CP  - England
KW  - Atrial fibrillation;  Biomarkers;  Exercise testing;  High-sensitivity cardiac troponin I;  High-sensitivity cardiac troponin T;  Rate control
AB  - BACKGROUND: High-sensitivity troponin I (hs-TnI) and troponin T (hs-TnT) are moderately correlated and independently related to outcome in atrial fibrillation (AF). Rate controlling therapy has been shown to reduce hs-TnT, however the potential impact on hs-TnI levels, and whether this differs from the effects on hs-TnT, has not been investigated previously.
AB  - METHODS: Sixty patients with stable, permanent AF without heart failure or known ischemic heart disease were included in a randomised crossover study (mean age 71 +/- 9 years, 18 women). Diltiazem 360 mg, verapamil 240 mg, metoprolol 100 mg, and carvedilol 25 mg were administered once daily for three weeks, in a randomised sequence. At baseline and on the last day of each treatment period, hs-TnI was measured at rest and after a maximal exercise test and compared to hs-TnT.
AB  - RESULTS: Hs-TnI and hs-TnT correlated moderately at baseline (rs = 0.582, p < 0.001). All drugs reduced both the resting and the peak exercise levels of hs-TnI compared with baseline (p < 0.001 for all). The decline in resting hs-TnI and hs-TnT values relative to baseline levels was similar for all drugs except for verapamil, which reduced hs-TnI more than hs-TnT (p = 0.017). Levels of hs-TnI increased significantly in response to exercise testing at baseline and at all treatment regimens (p < 0.001 for all). The relative exercise-induced increase in hs-TnI was significantly larger compared to hs-TnT at baseline (p < 0.001), on diltiazem (p < 0.001) and on verapamil (p = 0.001).
AB  - CONCLUSIONS: In our population of stable, permanent AF patients, all four rate control drug regimens reduced hs-TnI significantly, both at rest and during exercise. The decline in hs-TnI and hs-TnT levels associated with beta-blocker and calcium channel blocker treatment was similar, except for a larger relative decrease in hs-TnI levels following verapamil treatment.
AB  - TRIAL REGISTRATION: www.clinicaltrials.gov ( NCT00313157 ).
ES  - 1471-2261
IL  - 1471-2261
DO  - http://dx.doi.org/10.1186/s12872-016-0255-x
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
SI  - ClinicalTrials.gov
SA  - ClinicalTrials.gov/NCT00313157
SL  - http://clinicaltrials.gov/search/term=NCT00313157
LG  - English
EP  - 20160504
DP  - 2016
DC  - 20160504
YR  - 2016
RD  - 20160506
UP  - 20160627
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27142292

<1006. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27325337
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Shafrin J
AU  - Bruno A
AU  - MacEwan JP
AU  - Campinha-Bacote A
AU  - Trocio J
AU  - Shah M
AU  - Tan W
AU  - Romley JA
FA  - Shafrin, Jason
FA  - Bruno, Amanda
FA  - MacEwan, Joanna P
FA  - Campinha-Bacote, Avrita
FA  - Trocio, Jeffrey
FA  - Shah, Manan
FA  - Tan, Wilson
FA  - Romley, John A
IN  - Shafrin,Jason. Precision Health Economics, Los Angeles, CA, USA. Electronic address: Jason.shafrin@precisionhealtheconomics.com.
IN  - Bruno,Amanda. Bristol-Myers Squibb, Plainsboro, NJ, USA.
IN  - MacEwan,Joanna P. Precision Health Economics, Los Angeles, CA, USA.
IN  - Campinha-Bacote,Avrita. Precision Health Economics, Los Angeles, CA, USA.
IN  - Trocio,Jeffrey. Pfizer, Inc., New York, NY, USA.
IN  - Shah,Manan. Bristol-Myers Squibb, Plainsboro, NJ, USA.
IN  - Tan,Wilson. Pfizer, Inc., New York, NY, USA.
IN  - Romley,John A. University of Southern California, Los Angeles, CA, USA.
TI  - Physician and Patient Preferences for Nonvalvular Atrial Fibrillation Therapies.
SO  - Value in Health. 19(4):451-9, 2016 Jun.
AS  - Value Health. 19(4):451-9, 2016 Jun.
NJ  - Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 100883818
SB  - Index Medicus
CP  - United States
KW  - anticoagulants;  atrial fibrillation;  discrete choice experiment;  preferences;  willingness to pay
AB  - OBJECTIVES: The objective of this study was to compare patient and physician preferences for different antithrombotic therapies used to treat nonvalvular atrial fibrillation (NVAF).
AB  - METHODS: Patients diagnosed with NVAF and physicians treating such patients completed 12 discrete choice questions comparing NVAF therapies that varied across five attributes: stroke risk, major bleeding risk, convenience (no regular blood testing/dietary restrictions), dosing frequency, and patients' out-of-pocket cost. We used a logistic regression to estimate the willingness-to-pay (WTP) value for each attribute.
AB  - RESULTS: The 200 physicians surveyed were willing to trade off $38 (95% confidence interval [CI] $22 to $54] in monthly out-of-pocket cost for a 1% (absolute) decrease in stroke risk, $14 (95% CI $8 to $21) for a 1% decrease in major bleeding risk, and $34 (95% CI $9 to $60) for more convenience. The WTP value among 201 patients surveyed was $30 (95% CI $18 to $42) for reduced stroke risk, $16 (95% CI $9 to $24) for reduced bleeding risk, and -$52 (95% CI -$96 to -6) for convenience. The WTP value for convenience among patients using warfarin was $9 (95% CI $1 to $18) for more convenience, whereas patients not currently on warfarin had a WTP value of -$90 (95% CI -$290 to -$79). Both physicians' and patients' WTP value for once-daily dosing was not significantly different from zero. On the basis of survey results, 85.0% of the physicians preferred novel oral anticoagulants (NOACs) to warfarin. NOACs (73.0%) were preferred among patients using warfarin, but warfarin (78.2%) was preferred among patients not currently using warfarin. Among NOACs, both patients and physicians preferred apixaban.
AB  - CONCLUSIONS: Both physicians and patients currently using warfarin preferred NOACs to warfarin. Patients not currently using warfarin preferred warfarin over NOACs because of an apparent preference for regular blood testing/dietary restrictions.Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.
ES  - 1524-4733
IL  - 1098-3015
DI  - S1098-3015(16)00006-1
DO  - http://dx.doi.org/10.1016/j.jval.2016.01.001
PT  - Journal Article
LG  - English
EP  - 20160302
DP  - 2016 Jun
DC  - 20160621
YR  - 2016
UP  - 20160622
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27325337

<1007. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26410665
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Tang LH
AU  - Zwisler AD
AU  - Taylor RS
AU  - Doherty P
AU  - Zangger G
AU  - Berg SK
AU  - Langberg H
FA  - Tang, Lars H
FA  - Zwisler, Ann-Dorthe
FA  - Taylor, Rod S
FA  - Doherty, Patrick
FA  - Zangger, Graziella
FA  - Berg, Selina K
FA  - Langberg, Henning
IN  - Tang,Lars H. Department of Cardiology, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Denmark; CopenRehab, Section of Social Medicine, Department of Public Health, University of Copenhagen, Denmark; Bachelor's Degree Programme in Physiotherapy, Department of Rehabilitation and Nutrition, Faculty of Health and Technology, Metropolitan University College, Denmark; The Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Denmark. Electronic address: Lars.hermann.tang@regionh.dk.
IN  - Zwisler,Ann-Dorthe. Department of Cardiology, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Denmark; National Centre for Rehabilitation and Palliative Care, University of Southern Denmark and Odense University Hospital, Denmark.
IN  - Taylor,Rod S. Institute of Health Research, University of Exeter Medical School, United Kingdom; National Institute of Public Health, University of Southern Denmark, Denmark.
IN  - Doherty,Patrick. Department of Health Sciences, University of York, United Kingdom.
IN  - Zangger,Graziella. Department of Cardiology, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Denmark.
IN  - Berg,Selina K. Department of Cardiology, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Denmark.
IN  - Langberg,Henning. CopenRehab, Section of Social Medicine, Department of Public Health, University of Copenhagen, Denmark.
TI  - Self-rating level of perceived exertion for guiding exercise intensity during a 12-week cardiac rehabilitation programme and the influence of heart rate reducing medication.
SO  - Journal of Science & Medicine in Sport. 19(8):611-5, 2016 Aug.
AS  - J Sci Med Sport. 19(8):611-5, 2016 Aug.
NJ  - Journal of science and medicine in sport / Sports Medicine Australia
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - c54, 9812598
SB  - Index Medicus
CP  - Australia
KW  - Atrial fibrillation;  Exercise prescription;  Exercise therapy;  Heart rate;  Heart valve disease
AB  - OBJECTIVES: To investigate whether self-rating level of perceived exertion can adequately guide exercise intensity during a 12-week cardiac rehabilitation programme.
AB  - DESIGN: Linear regression analysis using rehabilitation data from two randomised controlled trials.
AB  - METHODS: Patients undergoing radiofrequency ablation for atrial fibrillation or following heart valve surgery and participating in exercise-based rehabilitation were included. The 12-week rehabilitation outpatient programme comprised three weekly training sessions, each consisting of 20min aerobic exercise divided into three steps. Patients were asked to base their exercise intensity for each step on a predefined rating of perceived exertion specified in a training diary. Exercise intensity was objectively measured by heart rate during the last 2min for each exercise step. Comparative analysis and linear regression of the rating of perceived exertion and heart rate were performed.
AB  - RESULTS: A total of 2622 ratings of perceived exertion were collected from 874 training sessions in 97 patients. Heart rate and rating of perceived exertion were associated both across all three exercise steps and individually for each step, with a mean of 6 to7bpm per 1-point difference in the rating of perceived exertion (p<0.001). Adjusting for rate-reducing medication slightly improved the strength of the association.
AB  - CONCLUSIONS: The association between change in the rating of perceived exertion and change in heart rate indicates that a diary-led and self-regulated model using rating of perceived exertion can help guide exercise intensity in everyday clinical practice among patients with heart disease, irrespective if they are taking heart rate-reducing medication.Copyright © 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
ES  - 1878-1861
IL  - 1878-1861
DI  - S1440-2440(15)00176-0
DO  - http://dx.doi.org/10.1016/j.jsams.2015.08.004
PT  - Journal Article
LG  - English
EP  - 20150910
DP  - 2016 Aug
DC  - 20160620
YR  - 2016
UP  - 20160621
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26410665

<1008. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27321791
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Fleming IO
AU  - Garratt C
AU  - Guha R
AU  - Desai J
AU  - Chaubey S
AU  - Wang Y
AU  - Leonard S
AU  - Kunst G
FA  - Fleming, Ian O
FA  - Garratt, Claire
FA  - Guha, Ranj
FA  - Desai, Jatin
FA  - Chaubey, Sanjay
FA  - Wang, Yanzhong
FA  - Leonard, Sara
FA  - Kunst, Gudrun
IN  - Fleming,Ian O. Anaesthesia.
IN  - Garratt,Claire. Anaesthesia.
IN  - Guha,Ranj. Anaesthesia.
IN  - Desai,Jatin. +Cardiac Surgery, King's College Hospital NHS Foundation Trust, London, UK.
IN  - Chaubey,Sanjay. +Cardiac Surgery, King's College Hospital NHS Foundation Trust, London, UK.
IN  - Wang,Yanzhong. ++Division of Health and Social Care Research, King's College London, London, UK.
IN  - Leonard,Sara. Anaesthesia; Department of Critical Care, King's College Hospital NHS Foundation Trust, London, UK.
IN  - Kunst,Gudrun. Anaesthesia. Electronic address: gudrun.kunst@kcl.ac.uk.
TI  - Aggregation of Marginal Gains in Cardiac Surgery: Feasibility of a Perioperative Care Bundle for Enhanced Recovery in Cardiac Surgical Patients.
SO  - Journal of Cardiothoracic & Vascular Anesthesia. 30(3):665-70, 2016 Jun.
AS  - J Cardiothorac Vasc Anesth. 30(3):665-70, 2016 Jun.
NJ  - Journal of cardiothoracic and vascular anesthesia
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - a6i, 9110208
SB  - Index Medicus
CP  - United States
KW  - cardiac surgery;  enhanced recovery;  perioperative quality improvement bundles;  postoperative morbidity
AB  - OBJECTIVES: The aim of this pilot study was to assess the feasibility of a perioperative care bundle for enhanced recovery after cardiac surgery (ERACS).
AB  - DESIGN: A prospective, observational study.
AB  - SETTING: A major urban teaching and university hospital and tertiary referral center.
AB  - PARTICIPANTS: The study included 53 patients undergoing cardiac surgery before implementation of an ERACS protocol (pre-ERACS group) and 52 patients undergoing cardiac surgery after implementation of an ERACS protocol (ERACS group).
AB  - INTERVENTIONS: Based on recommendations from a consensus review in colorectal surgery, the following enhanced recovery perioperative care bundle was applied: detailed preoperative information, avoidance of prolonged fasting periods preoperatively, preoperative carbohydrate beverages, optimization of analgesia with avoidance of long-acting opioids, prevention of postoperative nausea and vomiting, early enteral nutrition postoperatively, and early mobilization.
AB  - MEASUREMENTS AND MAIN RESULTS: The authors hypothesized that length of hospital stay would be reduced with ERACS. Secondary outcome variables included a composite of postoperative complications and pain scores. Whereas the length of stay in the group of patients receiving the bundle of enhanced recovery interventions remained unchanged compared with the non-ERACS group, there was a statistically significant reduction in the number of patients in the ERACS group presenting with one or more postoperative complications (including hospital-acquired infections, acute kidney injury, atrial fibrillation, respiratory failure, postoperative myocardial infarction, and death). In addition, postoperative pain scores were improved significantly in the ERACS group.
AB  - CONCLUSIONS: This pilot study demonstrated that ERACS is feasible and has the potential for improved postoperative morbidity after cardiac surgery. A larger multicenter quality improvement study implementing perioperative care bundles would be the next step to further assess outcomes in ERACS patients.Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
ES  - 1532-8422
IL  - 1053-0770
DI  - S1053-0770(16)00022-7
DO  - http://dx.doi.org/10.1053/j.jvca.2016.01.017
PT  - Journal Article
LG  - English
EP  - 20160116
DP  - 2016 Jun
DC  - 20160620
YR  - 2016
UP  - 20160621
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27321791

<1009. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26967541
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Lobos-Bejarano JM
AU  - Barrios V
AU  - Polo-Garcia J
AU  - Escobar C
AU  - Vargas-Ortega D
AU  - Marin-Montanes N
AU  - Prieto-Valiente L
AU  - Fuentes S
AU  - Prieto MA
AU  - Garcia-Ortiz L
AU  - on behalf the PAULA Study Team
FA  - Lobos-Bejarano, Jose M
FA  - Barrios, Vivencio
FA  - Polo-Garcia, Jose
FA  - Escobar, Carlos
FA  - Vargas-Ortega, Diego
FA  - Marin-Montanes, Nuria
FA  - Prieto-Valiente, Luis
FA  - Fuentes, Sonia
FA  - Prieto, Miguel Angel
FA  - Garcia-Ortiz, Luis
FA  - on behalf the PAULA Study Team
IN  - Lobos-Bejarano,Jose M. a Jazmin Primary Care Health Center, East Area Primary Care , Madrid , Spain ;
IN  - Barrios,Vivencio. b Cardiology Department , University Hospital Ramon y Cajal , Madrid , Spain ;
IN  - Polo-Garcia,Jose. c Primary Care Health Center Casar de Caceres , Caceres , Spain ;
IN  - Escobar,Carlos. d Cardiology Department , University Hospital La Paz , Madrid , Spain ;
IN  - Vargas-Ortega,Diego. e High Resolution Hospitalization Unit, Hospital el Toyo, Hospital de Poniente El Ejido , Almeria , Spain ;
IN  - Marin-Montanes,Nuria. f Medical Department , Bayer Hispania , Barcelona , Spain ;
IN  - Prieto-Valiente,Luis. g Medical Biostatistics, Universidad Catolica San Antonio de Murcia , Murcia , Spain ;
IN  - Fuentes,Sonia. h Primary Care Health Center , Barcelona , Spain ;
IN  - Prieto,Miguel Angel. i Vallobin-La Florida Primary Care Health Center , Oviedo , Spain ;
IN  - Prieto,Miguel Angel. j Medicine Preventive Department , Oviedo University , Asturias , Spain ;
IN  - Garcia-Ortiz,Luis. k Unit of Clinical Research La Alamedilla , Salamanca , Spain.
TI  - Evaluation of SAMe-TT2R2 score and other clinical factors influencing the quality of anticoagulation therapy in non-valvular atrial fibrillation: a nationwide study in Spain.
SO  - Current Medical Research & Opinion. 32(7):1201-7, 2016 Jul.
AS  - Curr Med Res Opin. 32(7):1201-7, 2016 Jul.
NJ  - Current medical research and opinion
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - dux, 0351014
SB  - Index Medicus
CP  - England
KW  - Anticoagulants;  Atrial fibrillation;  International normalized ratio;  Risk factors;  Vitamin K antagonists
AB  - OBJECTIVE: To assess the major clinical factors affecting the quality of anticoagulation and evaluate the predictive value of the SAMe-TT2R2 score to identify patients who will achieve a high average time in therapeutic range (T.T.R.) with vitamin K antagonist (V.K.A.) treatment.
AB  - RESEARCH DESIGN AND METHODS: This observational, cross-sectional, retrospective and nationwide multicenter study included 1524 patients from the primary care setting with non-valvular atrial fibrillation receiving V.K.A. (>12 months). We performed a bivariate analysis to identify factors individually associated with the T.T.R. and a multiple regression analysis to identify the independent predictive factors. For the validation of the SAMe-TT2R2 score, the receiver operating characteristic (R.O.C.) curve was calculated and the Hosmer-Lemeshow test was used to test calibration.
AB  - RESULTS: A total of 94.8% of patients received acenocumarol (4.8% warfarin). A progressive decrease in mean T.T.R. was found when the SAMe-TT2R2 score increased from 0 points (72.1+/-17.1%) to 4 points (64.1+/-23.2%), p<0.001. Other risk scores (CHADS2 and CHA2DS2-VASc, HAS-BLED) were also associated with the mean T.T.R. We found a significant association between low T.T.R. and the following clinical factors: female sex, three or more comorbidities, amiodarone treatment, dietary habits, bleeding history and the intake of >7 tablets per day besides V.K.A. (p<0.01). Regarding SAMe-TT2R2 score validation, the R.O.C. curve showed significant capability, although not high, of discriminating good anticoagulation control (T.T.R. >65%) with an area under the curve of 0.562 (95% C.I. 0.533-0.592, p<0.001) which increased, remaining modest, to 0.594 (95% C.I. 0.564-0.624, p<0.001) when the factors not included in SAMe-TT2R2 score were added.
AB  - CONCLUSION: In this cohort, the SAMe-TT2R2 score had a significant, although modest, ability to assess the likelihood of good international normalized ration (I.N.R.) control, and its predictive value might slightly improve by adding other simple clinical factors. Further research is needed to refine the predictive scales.
ES  - 1473-4877
IL  - 0300-7995
DO  - http://dx.doi.org/10.1185/03007995.2016.1164676
PT  - Journal Article
LG  - English
EP  - 20160407
DP  - 2016 Jul
DC  - 20160618
YR  - 2016
UP  - 20160620
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26967541

<1010. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26803238
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Santos-Lozano A
AU  - Sanchis-Gomar F
AU  - Barrero-Santalla S
AU  - Pareja-Galeano H
AU  - Cristi-Montero C
AU  - Sanz-Ayan P
AU  - Garatachea N
AU  - Fiuza-Luces C
AU  - Lucia A
FA  - Santos-Lozano, Alejandro
FA  - Sanchis-Gomar, Fabian
FA  - Barrero-Santalla, Saray
FA  - Pareja-Galeano, Helios
FA  - Cristi-Montero, Carlos
FA  - Sanz-Ayan, Paz
FA  - Garatachea, Nuria
FA  - Fiuza-Luces, Carmen
FA  - Lucia, Alejandro
IN  - Santos-Lozano,Alejandro. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; GIDFYS, European University Miguel de Cervantes, Department of Health Sciences, Valladolid, Spain.
IN  - Sanchis-Gomar,Fabian. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain. Electronic address: fabian.sanchis@uv.es.
IN  - Barrero-Santalla,Saray. School of Health Sciences, University of Leon, Leon, Spain.
IN  - Pareja-Galeano,Helios. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; European University of Madrid, Madrid, Spain.
IN  - Cristi-Montero,Carlos. IRyS group, School of Physical Education, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile; Universidad Autonoma de Chile, Temuco, Chile.
IN  - Sanz-Ayan,Paz. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
IN  - Garatachea,Nuria. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, Huesca, Spain.
IN  - Fiuza-Luces,Carmen. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
IN  - Lucia,Alejandro. Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; European University of Madrid, Madrid, Spain.
TI  - Exercise as an adjuvant therapy against chronic atrial fibrillation.
SO  - International Journal of Cardiology. 207:180-4, 2016 Mar 15.
AS  - Int J Cardiol. 207:180-4, 2016 Mar 15.
NJ  - International journal of cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - gqw, 8200291
SB  - Index Medicus
CP  - Netherlands
KW  - Arrhythmias;  Atrial fibrillation;  Cardiovascular disease;  Exercise
ES  - 1874-1754
IL  - 0167-5273
DI  - S0167-5273(16)30138-3
DO  - http://dx.doi.org/10.1016/j.ijcard.2016.01.140
PT  - Letter
LG  - English
EP  - 20160109
DP  - 2016 Mar 15
DC  - 20160217
YR  - 2016
UP  - 20160616
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26803238

<1011. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27297852
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Reiffel JA
AU  - Weitz JI
AU  - Reilly P
AU  - Kaminskas E
AU  - Sarich T
AU  - Sager P
AU  - Seltzer J
AU  - Cardiac Safety Research Consortium presenters and participants
FA  - Reiffel, James A
FA  - Weitz, Jeffrey I
FA  - Reilly, Paul
FA  - Kaminskas, Edvardas
FA  - Sarich, Troy
FA  - Sager, Philip
FA  - Seltzer, Jonathan
FA  - Cardiac Safety Research Consortium presenters and participants
IN  - Reiffel,James A. Columbia University, New York, NY. Electronic address: jar2@cumc.columbia.edu.
IN  - Weitz,Jeffrey I. McMaster University and Thrombosis and Atherosclerosis Research Institute, Ontario, Canada.
IN  - Reilly,Paul. Employee of Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT.
IN  - Kaminskas,Edvardas. Division of Hematology Products, CDER, FDA, Silver Springs, MD.
IN  - Sarich,Troy. Employee of Janssen Scientific Affairs, LLC, Titusville, NJ.
IN  - Sager,Philip. Stanford University and Sager Consulting Experts, San Francisco, CA.
IN  - Seltzer,Jonathan. Employee of ACI Clinical and Lankenau Heart Institute, Wynnewood, PA.
TI  - NOAC monitoring, reversal agents, and post-approval safety and effectiveness evaluation: A cardiac safety research consortium think tank. [Review]
SO  - American Heart Journal. 177:74-86, 2016 Jul.
AS  - Am Heart J. 177:74-86, 2016 Jul.
NJ  - American heart journal
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 0370465
SB  - Core Clinical Journals (AIM)
SB  - Index Medicus
CP  - United States
AB  - Four non-vitamin K antagonist oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) have been approved in the United States for treatment of atrial fibrillation (AF) and venous thromboembolic disease. They have been as or more effective than the prior standards of care, with less fatal or intracranial bleeding, fewer drug and dietary interactions, and greater patient convenience. Nonetheless, the absence of the ability for clinicians to assess compliance or washout with a simple laboratory test (or to adjust dosing with a similar assessment) and the absence of an antidote to rapidly stop major hemorrhage or to enhance safety in the setting of emergent or urgent surgery/procedures have been limitations to greater non-vitamin K antagonist oral anticoagulant usage and better thromboembolic prevention. Accordingly, a Cardiac Research Safety Consortium "think tank" meeting was held in February 2015 to address these concerns. This manuscript reports on the discussions held and the conclusions reached at that meeting. Copyright © 2016 Elsevier Inc. All rights reserved.
ES  - 1097-6744
IL  - 0002-8703
DI  - S0002-8703(16)30030-8
DO  - http://dx.doi.org/10.1016/j.ahj.2016.04.010
PT  - Journal Article
PT  - Review
LG  - English
EP  - 20160423
DP  - 2016 Jul
DC  - 20160614
YR  - 2016
UP  - 20160615
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27297852

<1012. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27283289
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Ding L
AU  - Quan XQ
AU  - Zhang S
AU  - Ruan L
AU  - Zhang L
AU  - Zheng K
AU  - Yu WW
AU  - Wu XF
AU  - Mi T
AU  - Zhang CT
AU  - Zhou HL
FA  - Ding, Ling
FA  - Quan, Xiao-Qing
FA  - Zhang, Shu
FA  - Ruan, Lei
FA  - Zhang, Le
FA  - Zheng, Kai
FA  - Yu, Wei-Wei
FA  - Wu, Xiao-Fen
FA  - Mi, Tao
FA  - Zhang, Cun-Tai
FA  - Zhou, Hong-Lian
IN  - Ding,Ling. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Quan,Xiao-Qing. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Zhang,Shu. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Ruan,Lei. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Zhang,Le. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Zheng,Kai. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Yu,Wei-Wei. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Wu,Xiao-Fen. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Mi,Tao. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Zhang,Cun-Tai. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
IN  - Zhou,Hong-Lian. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. zhouhonglian63@163.com.
TI  - Correlation between impedance cardiography and 6 min walk distance in atrial fibrillation patients.
SO  - BMC Cardiovascular Disorders. 16:133, 2016.
AS  - BMC Cardiovasc Disord. 16:133, 2016.
NJ  - BMC cardiovascular disorders
PI  - Journal available in: Electronic
PI  - Citation processed from: Internet
JC  - 100968539
OI  - Source: NLM. PMC4901461
SB  - Index Medicus
CP  - England
KW  - 6 min walk distance;  Atrial fibrillation;  Impedance cardiography
AB  - BACKGROUND: The correlation between impedance cardiography (ICG) and 6 min walk distance (6MWD) in atrial fibrillation (AF) patients remains unknown.
AB  - METHODS: We recruited 49 subjects in the study (21 AF patients and 28 patients without AF) and estimated hemodynamic parameters: cardiac output (CO), stroke volume (SV), stroke volume index (SVI), left stroke work (LSW), left stroke work index (LSWI), stroke systemic vascular resistance (SSVR), stroke systemic vascular resistance index (SSVRI); 6MWD, left ventricle ejection fraction (LVEF), NT-pro brain natriuretic peptide (NT-pro BNP) for the two groups.
AB  - RESULTS: The AF group have apparently lower CO (2.26+/-0.14 VS 4.11+/-0.20 L/min, p=0.039) and distinctly higher SVR (677.60+/-69.10 VS 344.41+/-22.98 dynes/cm(5), p=0.001), SSVRI (396.97+/-36.80 VS 199.01+/-11.72 dynes/cm(5)/m(2), p<0.001) than the control group. NT-pro BNP (1409.48+/-239.90 VS 332.59+/-68.85 pg/ml, p=0.001) in the AF group was significantly higher than the control group and 6MWD (264.33+/-14.55 VS 428.79+/-29.98 m, p<0.001) in the AF group was lower than the control group. There was no significant difference in LVEF between the two groups (62.67+/-7.62 % VS 63.93+/-5.03 %, p=0.470). Pearson correlation analysis revealed that CO (R=0.494, p=0.023), SV (R=0.633, p=0.002), LSW (R=0.615, p=0.003) and LSWI (R=0.491, p=0.024) significantly correlated positively with 6MWD in AF patients.
AB  - CONCLUSIONS: AF patients had lower cardiac output, shorter 6MWD and higher NT-pro BNP than patients with sinus rhythm. The cardiac output measured by impedance cardiography significantly correlated positively with 6MWD in AF patients.
ES  - 1471-2261
IL  - 1471-2261
DO  - http://dx.doi.org/10.1186/s12872-016-0297-0
PT  - Journal Article
LG  - English
EP  - 20160610
DP  - 2016
DC  - 20160610
YR  - 2016
RD  - 20160612
UP  - 20160614
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27283289

<1013. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27276892
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Uchida K
AU  - Wada Y
AU  - Ariyoshi T
AU  - Okuda S
AU  - Murakami W
AU  - Myoren T
AU  - Harada N
AU  - Yamamoto T
AU  - Ueyama T
AU  - Tanaka N
AU  - Yano M
FA  - Uchida, Kosuke
FA  - Wada, Yasuaki
FA  - Ariyoshi, Toru
FA  - Okuda, Shinichi
FA  - Murakami, Wakako
FA  - Myoren, Takeki
FA  - Harada, Noriko
FA  - Yamamoto, Takeshi
FA  - Ueyama, Takeshi
FA  - Tanaka, Nobuaki
FA  - Yano, Masafumi
IN  - Uchida,Kosuke. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Wada,Yasuaki. Division of Laboratory, Yamaguchi University Hospital, Minami-Kogushi 1-1-1, Ube, Yamaguchi, 755-8505, Japan. wadayasu@yamaguchi-u.ac.jp.
IN  - Ariyoshi,Toru. Division of Laboratory, Yamaguchi University Hospital, Minami-Kogushi 1-1-1, Ube, Yamaguchi, 755-8505, Japan.
IN  - Okuda,Shinichi. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Murakami,Wakako. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Myoren,Takeki. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Harada,Noriko. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Yamamoto,Takeshi. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Ueyama,Takeshi. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Tanaka,Nobuaki. Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
IN  - Yano,Masafumi. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
TI  - Kinetics of left ventricular rotation during exercise and its relation to exercise tolerance in atrial fibrillation: assessment by two-dimensional speckle tracking echocardiography.
SO  - Journal of Echocardiography. 12(3):89-97, 2014 Sep.
AS  - J. echocardiogr.. 12(3):89-97, 2014 Sep.
NJ  - Journal of echocardiography
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101263153
SB  - Index Medicus
CP  - Japan
KW  - Atrial fibrillation;  Exercise stress echocardiography;  Exercise tolerance;  Left ventricular rotation
AB  - BACKGROUND: Left ventricular (LV) rotation plays an important role in cardiac function both at rest and during exercise in sinus rhythm. The kinetics of rotation during exercise and the relation between exercise tolerance and rotation-related parameters in patients with atrial fibrillation (AF) are unknown.
AB  - METHODS: Twenty-nine patients (age 62 +/- 13 years, 6 females) with AF and preserved LV ejection fraction (LVEF) were studied using two-dimensional speckle tracking echocardiography at rest and during exercise with a supine bicycle ergometer (20 W, 10 min). We measured the systolic rotation (Rot) and the peak rotation rate in systole and early diastole (eRotR) at the apical and basal levels of the LV. All patients underwent cardiopulmonary exercise testing to obtain their percent achieved of the predicted peak oxygen consumption (% peak VO2) value.
AB  - RESULTS: During exercise, apical Rot-related indices were significantly increased only in the preserved % peak VO2 group. In contrast, E/e' was significantly elevated only in the reduced % peak VO2 group. Multivariable stepwise regression analysis showed that apical DELTARot was independently associated with % peak VO2 (beta = 0.72; p < 0.01). Apical DELTAeRotR, which could not be selected as an independent predictor of % peak VO2, had a good linear correlation with apical DELTARot (r = 0.81, p < 0.01).
AB  - CONCLUSIONS: The augmentation of apical rotation in response to exercise may coincide with an increase of the apical derotation rate, and apical rotation reserve may reflect exercise tolerance in patients with AF and preserved LVEF.
ES  - 1880-344X
IL  - 1349-0222
DO  - http://dx.doi.org/10.1007/s12574-014-0205-5
PT  - Journal Article
LG  - English
EP  - 20140211
DP  - 2014 Sep
DC  - 20160609
YR  - 2014
UP  - 20160610
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27276892

<1014. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26692555
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Charitakis E
AU  - Walfridsson U
AU  - Nystrom F
AU  - Nylander E
AU  - Stromberg A
AU  - Alehagen U
AU  - Walfridsson H
FA  - Charitakis, Emmanouil
FA  - Walfridsson, Ulla
FA  - Nystrom, Fredrik
FA  - Nylander, Eva
FA  - Stromberg, Anna
FA  - Alehagen, Urban
FA  - Walfridsson, Hakan
IN  - Charitakis,Emmanouil. Department of Cardiology and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
IN  - Walfridsson,Ulla. Department of Cardiology and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
IN  - Nystrom,Fredrik. Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden.
IN  - Nylander,Eva. Department of Clinical Physiology and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
IN  - Stromberg,Anna. Department of Cardiology and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
IN  - Alehagen,Urban. Department of Cardiology and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
IN  - Walfridsson,Hakan. Department of Cardiology and Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
TI  - Symptom burden, Metabolic profile, Ultrasound findings, Rhythm, neurohormonal activation, haemodynamics and health-related quality of life in patients with atrial Fibrillation (SMURF): a protocol for an observational study with a randomised interventional component.
SO  - BMJ Open. 5(12):e008723, 2015.
AS  - BMJ Open. 5(12):e008723, 2015.
NJ  - BMJ open
PI  - Journal available in: Electronic
PI  - Citation processed from: Internet
JC  - 101552874
OI  - Source: NLM. PMC4691757
SB  - Index Medicus
CP  - England
AB  - INTRODUCTION: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with an estimated prevalence of 1.5-2%. It is an independent risk factor for ischaemic stroke and is estimated to cause about 20-25% of all stroke cases. AF has a great impact on health-related quality of life (HRQoL); however, one unresolved issue related to AF is the wide variation in its symptoms.
AB  - METHODS AND ANALYSIS: The symptom burden, metabolic profile, ultrasound findings, rhythm, neurohormonal activation, haemodynamics and HRQoL in patients with AF (Symptom burden, Metabolic profile, Ultrasound findings, Rhythm, neurohormonal activation, haemodynamics and health-related quality of life in patients with atrial Fibrillation, SMURF) study is a prospective observational, cohort study, with a randomised interventional part. The aim of the study is to investigate, in patients with AF, the relationship between symptom burden and metabolic aspects, atrial function and different neurohormones, and the effect of radiofrequency ablation (RFA). The interventional part of the study will give an insight into the neurohormonal and intracardiac pressure changes directly after initiation of AF. Consecutive patients with symptomatic AF accepted for treatment with RFA for the first time at Linkoping University Hospital are eligible for participation. The enrolment started in January 2012, and a total of 200 patients are to be included into the study, with 45 of them being enrolled into the interventional study with initiation of AF. The sample size of the interventional study is based on a small pilot study with 5 patients induced to AF while 2 served as controls. The results indicated that, in order to find a statistically significant difference, there was a need to include 28 patients; for safety reasons, 45 patients will be included.
AB  - ETHICS AND DISSEMINATION: The SMURF study is approved by the Regional Ethical Review Board at the Faculty of Health Sciences, Linkoping, Sweden. The results will be presented through peer-review journals and conference presentation.
AB  - TRIAL REGISTRATION NUMBER: NCT01553045; Pre-results.Copyright Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
ES  - 2044-6055
IL  - 2044-6055
DO  - http://dx.doi.org/10.1136/bmjopen-2015-008723
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
SI  - ClinicalTrials.gov
SA  - ClinicalTrials.gov/NCT01553045
SL  - http://clinicaltrials.gov/search/term=NCT01553045
LG  - English
EP  - 20151221
DP  - 2015
DC  - 20151222
YR  - 2015
RD  - 20151231
UP  - 20160606
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26692555

<1015. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25534011
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Limite LR
AU  - Magnoni M
AU  - Berteotti M
AU  - Peretto G
AU  - Durante A
AU  - Cristell N
AU  - Laricchia A
AU  - Camici PG
AU  - Alfieri O
AU  - Cianflone D
FA  - Limite, Luca R
FA  - Magnoni, Marco
FA  - Berteotti, Martina
FA  - Peretto, Giovanni
FA  - Durante, Alessandro
FA  - Cristell, Nicole
FA  - Laricchia, Alessandra
FA  - Camici, Paolo G
FA  - Alfieri, Ottavio
FA  - Cianflone, Domenico
IN  - Limite,Luca R. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Magnoni,Marco. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Berteotti,Martina. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Peretto,Giovanni. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Durante,Alessandro. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Cristell,Nicole. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Laricchia,Alessandra. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Camici,Paolo G. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Alfieri,Ottavio. Cardiovascular Department, San Raffaele Scientific Institute, Italy.
IN  - Cianflone,Domenico. Cardiovascular Department, San Raffaele Scientific Institute, Italy cianflone.domenico@hsr.it.
TI  - The predictive role of renal function and systemic inflammation on the onset of de novo atrial fibrillation after cardiac surgery.
SO  - European Journal of Preventive Cardiology. 23(2):206-13, 2016 Jan.
AS  - Eur J Prev Cardiolog. 23(2):206-13, 2016 Jan.
NJ  - European journal of preventive cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101564430
SB  - Index Medicus
CP  - England
KW  - Atrial fibrillation;  cardiac surgery;  inflammation;  renal function
AB  - BACKGROUND: The association between postoperative atrial fibrillation (POAF) and renal function was previously grounded in patients undergoing coronary artery bypass grafting through unknown mechanisms. We aim to investigate the association between renal function and POAF in a cohort composed mostly of patients undergoing valve surgery and to explore the role of inflammation as a pathogenic mechanism linking renal dysfunction and arrhythmogenesis.
AB  - METHODS: Altogether 444 patients who underwent cardiac surgery without previous history of atrial fibrillation were analysed. Serum creatinine and high sensitivity C-reactive protein (hs-CRP) concentrations were obtained at baseline and on the 3rd, 8th and 15th postoperative day; estimated glomerular filtration rate (eGFR) was calculated by the Modified Diet Renal Disease (MDRD) formula. Patients were divided into three groups on the basis of baseline eGFR.
AB  - RESULTS: Overall, 173 (39%) patients developed POAF, 29.5% in the group with normal eGFR (>90ml/min/1.73m(2)), 43.3% among patients with eGFR 60-90ml/min/1.73m(2) and 55.6% in the group with eGFR <60ml/min/1.73m(2). Patients developing POAF had lower eGFR on all the samples. At baseline preoperatively hs-CRP levels did not differ in the two groups.On multivariate analysis, age and eGFR were identified as independent predictors of POAF. The risk of POAF progressively increased from mild impairment (odds ratio (OR) 1.59, 95% confidence interval (CI) 1.01-2.50) to severe reduction of renal function (OR 2.35, 95% CI 1.25-4.48).
AB  - CONCLUSIONS: Age and eGFR were identified as the strongest predictors of POAF in a population largely composed of valve surgery patients. Renal function, even from early stage, is independently associated with the increasing risk of developing POAF.Copyright © The European Society of Cardiology 2014.
ES  - 2047-4881
IL  - 2047-4873
DO  - http://dx.doi.org/10.1177/2047487314564896
PT  - Journal Article
LG  - English
EP  - 20141222
DP  - 2016 Jan
DC  - 20160203
YR  - 2016
UP  - 20160601
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25534011

<1016. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26987488
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Yasaka M
AU  - Minematsu K
AU  - Toyoda K
AU  - Yamagami H
AU  - Yoshimura S
AU  - Nagao T
AU  - Mori E
AU  - Hirano T
AU  - Hamasaki T
AU  - Yamaguchi T
FA  - Yasaka, Masahiro
FA  - Minematsu, Kazuo
FA  - Toyoda, Kazunori
FA  - Yamagami, Hiroshi
FA  - Yoshimura, Shinichi
FA  - Nagao, Takehiko
FA  - Mori, Etsuro
FA  - Hirano, Teruyuki
FA  - Hamasaki, Toshimitsu
FA  - Yamaguchi, Takenori
IN  - Yasaka,Masahiro. Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan. Electronic address: yasaka@kyumed.jp.
IN  - Minematsu,Kazuo. Japan Cardiovascular Research Foundation, Suita, Japan; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
IN  - Toyoda,Kazunori. Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
IN  - Yamagami,Hiroshi. Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
IN  - Yoshimura,Shinichi. Department of Neurosurgery, Hyogo College of Medicine, Hyogo, Japan.
IN  - Nagao,Takehiko. Department of Neurology, Nippon Medical School Tama-Nagayama Hospital, Tokyo, Japan.
IN  - Mori,Etsuro. Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate, School of Medicine, Sendai, Japan.
IN  - Hirano,Teruyuki. Department of Stroke and Cerebrovascular Medicine, Kyorin University, Tokyo, Japan.
IN  - Hamasaki,Toshimitsu. Department of Advanced Medical Technology Development, National Cerebral and Cardiovascular Center, Suita, Japan.
IN  - Yamaguchi,Takenori. Japan Cardiovascular Research Foundation, Suita, Japan; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
TI  - Design and Rationale of the RELAXED (Recurrent Embolism Lessened by rivaroxaban, an Anti-Xa agent, of Early Dosing for acute ischemic stroke and transient ischemic attack with atrial fibrillation) Study.
SO  - Journal of Stroke & Cerebrovascular Diseases. 25(6):1342-8, 2016 Jun.
AS  - J STROKE CEREBROVASC DIS. 25(6):1342-8, 2016 Jun.
NJ  - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 9111633
SB  - Index Medicus
CP  - United States
KW  - Nonvalvular atrial fibrillation;  design;  rivaroxaban;  secondary prevention
AB  - BACKGROUND: In the acute phase of cardioembolic stroke in patients with nonvalvular atrial fibrillation (NVAF), the recurrence rate is high. Nonvitamin K antagonist oral anticoagulants may be appropriate for prevention of early recurrence because they have a much lower risk of hemorrhagic stroke than warfarin.
AB  - METHODS: RELAXED (Recurrent Embolism Lessened by rivaroxaban, an Anti-Xa agent, of Early Dosing for acute ischemic stroke and transient ischemic attack with atrial fibrillation) study is an observational study designed to investigate the optimal timing to start administration of rivaroxaban for prevention of recurrence in NVAF patients in the acute phase of cardioembolic stroke (ClinicalTrials.gov: NCT02129920 and UMIN-clinical trials registry: UMIN000013932). It will evaluate the efficacy and safety of rivaroxaban with regard to infarct size, timing of initiation of rivaroxaban medication, and other patient characteristics. A total of 2000 consecutive patients with acute ischemic stroke in the territory of the middle cerebral artery and NVAF will be enrolled in 100 institutes throughout Japan, and they will receive rivaroxaban within 30 days of the index stroke for secondary prevention of stroke. The infarct size within 48 hours after stroke onset will be measured by diffusion-weighted magnetic resonance imaging. The primary efficacy endpoint is recurrent ischemic stroke, and the primary safety endpoint is major bleeding during the observational period of 3 months after stroke onset. The optimal timing to start treatment with rivaroxaban during the acute stage of ischemic stroke will be determined by analysis of the correlation between primary endpoints and the size of cerebral infarct.
AB  - CONCLUSIONS: The RELAXED observational registry study will elucidate the optimal timing of the initiation of rivaroxaban in acute cardioembolic stroke associated with NVAF.Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
ES  - 1532-8511
IL  - 1052-3057
DI  - S1052-3057(16)00062-8
DO  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.035
PT  - Journal Article
LG  - English
EP  - 20160314
DP  - 2016 Jun
DC  - 20160528
YR  - 2016
UP  - 20160531
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26987488

<1017. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26365270
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Merinopoulos I
AU  - Venables P
AU  - Chalmers I
AU  - Vassiliou V
FA  - Merinopoulos, Ioannis
FA  - Venables, Paul
FA  - Chalmers, Isobel
FA  - Vassiliou, Vassilios
IN  - Merinopoulos,Ioannis. Department of Cardiology, Ipswich Hospital, Ipswich, IP4 5PD1, UK. i_merinopoulos@hotmail.com.
TI  - NOAC or Warfarin for Atrial Fibrillation: Does Time in Therapeutic Range Matter?.
SO  - Recent Advances In Cardiovascular Drug Discovery. 10(1):60-4, 2015.
AS  - Recent Adv Cardiovasc Drug Discov. 10(1):60-4, 2015.
NJ  - Recent advances in cardiovascular drug discovery
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - 101677661
SB  - Index Medicus
CP  - United Arab Emirates
AB  - Atrial fibrillation (AF) is the commonest cardiac arrhythmia currently affecting 1-2% of the general population, with stroke being one of its most fearsome complications. Dose-adjusted warfarin is an established treatment for reduction of thromboembolic risk but mandates dietary restrictions and need for routine blood monitoring. Novel oral anticoagulants (Dabigatran - patent: US20110082299A1, manufactured by Boehringer Ingelheim; Rivaroxaban - patent: US20150175590A1, manufactured by Bayer; Apixaban - patent: US20140335178A1, manufactured jointly by Pfizer and Bristol-Myers Squibb; Edoxaban - patent: WO2013026553A1, manufactured by Daiichi Sankyo) have recently been introduced that might provide at least equal reduction in thromboembolic risk to patients; negating the need for dietary restrictions and routine blood tests. The most recent National Institute of Health and Care Excellence, UK guidelines from August 2014 suggest consideration of one of the novel oral anticoagulants if the time in therapeutic range is less than 65%. In this study, the evidence for four novel oral anticoagulants is reviewed and the anticoagulation success with warfarin with atrial fibrillation and mechanical heart valves assessed in a large UK District General Hospital. Fifty-eight patients were identified with mechanical heart valve and 2737 patients with atrial fibrillation. Patients with atrial fibrillation had a significantly better TTR when compared with the patients included in the NOAC trials. Our results were similar with the Auricula registry. However, 25% of patients had TTR<65% and they would need to be considered for NOACs. Our data suggest that the degree of benefit seen in the NOAC trials might not be expected in our cohort of patients with atrial fibrillation. Interestingly, our patients with atrial fibrillation had a much better mean TTR of 76.4% and required less INR tests (12/year) compared to patients with mechanical heart valve who had a mean TTR of 61.4% and required more INR tests (26/year).
ES  - 2212-3962
IL  - 1574-8901
PT  - Journal Article
LG  - English
DP  - 2015
DC  - 20160115
YR  - 2015
UP  - 20160527
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26365270

<1018. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26813889
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Dixit S
AU  - Stein PK
AU  - Dewland TA
AU  - Dukes JW
AU  - Vittinghoff E
AU  - Heckbert SR
AU  - Marcus GM
FA  - Dixit, Shalini
FA  - Stein, Phyllis K
FA  - Dewland, Thomas A
FA  - Dukes, Jonathan W
FA  - Vittinghoff, Eric
FA  - Heckbert, Susan R
FA  - Marcus, Gregory M
IN  - Dixit,Shalini. University of California, San Francisco, San Francisco, CA (S.D., J.W.D., E.V., G.M.M.).
IN  - Stein,Phyllis K. Washington University School of Medicine, St. Louis, MO (P.K.S.).
IN  - Dewland,Thomas A. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR (T.A.D.).
IN  - Dukes,Jonathan W. University of California, San Francisco, San Francisco, CA (S.D., J.W.D., E.V., G.M.M.).
IN  - Vittinghoff,Eric. University of California, San Francisco, San Francisco, CA (S.D., J.W.D., E.V., G.M.M.).
IN  - Heckbert,Susan R. University of Washington and Group Health Research Institute, Seattle, WA (S.R.H.).
IN  - Marcus,Gregory M. University of California, San Francisco, San Francisco, CA (S.D., J.W.D., E.V., G.M.M.).
TI  - Consumption of Caffeinated Products and Cardiac Ectopy.
CM  - Comment in: J Am Heart Assoc. 2016 Jan;5(1). pii: e003089. doi: 10.1161/JAHA.115.003089; PMID: 26813891
SO  - Journal of the American Heart Association. 5(1), 2016 Jan.
AS  - J Am Heart Assoc. 5(1), 2016 Jan.
NJ  - Journal of the American Heart Association
PI  - Journal available in: Electronic
PI  - Citation processed from: Internet
JC  - 101580524
OI  - Source: NLM. PMC4859368
SB  - Index Medicus
CP  - England
KW  - arrhythmia;  diet;  electrophysiology;  epidemiology
AB  - BACKGROUND: Premature cardiac contractions are associated with increased morbidity and mortality. Though experts associate premature atrial contractions (PACs) and premature ventricular contractions (PVCs) with caffeine, there are no data to support this relationship in the general population. As certain caffeinated products may have cardiovascular benefits, recommendations against them may be detrimental.
AB  - METHODS AND RESULTS: We studied Cardiovascular Health Study participants with a baseline food frequency assessment, 24-hour ambulatory electrocardiography (Holter) monitoring, and without persistent atrial fibrillation. Frequencies of habitual coffee, tea, and chocolate consumption were assessed using a picture-sort food frequency survey. The main outcomes were PACs/h and PVCs/hour. Among 1388 participants (46% male, mean age 72 years), 840 (61%) consumed >1 caffeinated product per day. The median numbers of PACs and PVCs/h and interquartile ranges were 3 (1-12) and 1 (0-7), respectively. There were no differences in the number of PACs or PVCs/h across levels of coffee, tea, and chocolate consumption. After adjustment for potential confounders, more frequent consumption of these products was not associated with ectopy. In examining combined dietary intake of coffee, tea, and chocolate as a continuous measure, no relationships were observed after multivariable adjustment: 0.48% fewer PACs/h (95% CI -4.60 to 3.64) and 2.87% fewer PVCs/h (95% CI -8.18 to 2.43) per 1-serving/week increase in consumption.
AB  - CONCLUSIONS: In the largest study to evaluate dietary patterns and quantify cardiac ectopy using 24-hour Holter monitoring, we found no relationship between chronic consumption of caffeinated products and ectopy.Copyright © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.
ES  - 2047-9980
IL  - 2047-9980
DI  - e002503
DO  - http://dx.doi.org/10.1161/JAHA.115.002503
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
NO  - HHSN268200800007C (United States PHS HHS)
NO  - HHSN268201200036C (United States PHS HHS)
NO  - N01HC55222 (United States NHLBI NIH HHS)
NO  - N01HC85079 (United States NHLBI NIH HHS)
NO  - N01HC85080 (United States NHLBI NIH HHS)
NO  - N01HC85081 (United States NHLBI NIH HHS)
NO  - N01HC85082 (United States NHLBI NIH HHS)
NO  - N01HC85083 (United States NHLBI NIH HHS)
NO  - N01HC85086 (United States NHLBI NIH HHS)
NO  - R01AG023629 (United States NIA NIH HHS)
NO  - TL1 TR000144 (United States NCATS NIH HHS)
NO  - U01HL080295 (United States NHLBI NIH HHS)
LG  - English
EP  - 20160126
DP  - 2016 Jan
DC  - 20160127
YR  - 2016
RD  - 20160521
UP  - 20160526
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26813889

<1019. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26559414
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Volpe R
AU  - Sotis G
AU  - Cianciabella M
FA  - Volpe, Roberto
FA  - Sotis, Gianluca
FA  - Cianciabella, Marta
IN  - Volpe,Roberto. EWHETA (Eat Well for an HEalthy Third Age) Project, Italian National Research Council, Rome, Italy. roberto.volpe@cnr.it.
IN  - Sotis,Gianluca. EWHETA (Eat Well for an HEalthy Third Age) Project, Italian National Research Council, Rome, Italy.
IN  - Cianciabella,Marta. EWHETA (Eat Well for an HEalthy Third Age) Project, Italian National Research Council, Bologna, Italy.
TI  - Is it always Alzheimer's? Let's talk to our patients about "cardiocerebrovascular" prevention.
SO  - Aging-Clinical & Experimental Research. 28(1):159-60, 2016 Feb.
AS  - Aging Clin Exp Res. 28(1):159-60, 2016 Feb.
NJ  - Aging clinical and experimental research
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101132995
SB  - Index Medicus
CP  - Germany
KW  - Alzheimer;  Prevention;  Risk factors;  Vascular dementia
AB  - Unlike Alzheimer's, vascular dementia can, in part, be prevented. The preventive approach foresees treatment for high blood pressure, atrial fibrillation, diabetes, high cholesterol, low HDL cholesterol, sedentary lifestyle, smoking, alcohol abuse, obesity, and sleep apnea. Moreover, also a well-balanced diet and physical activity are cornerstones of prevention, with beneficial effects on the brain and cognition.
ES  - 1720-8319
IL  - 1594-0667
DO  - http://dx.doi.org/10.1007/s40520-015-0480-7
PT  - Journal Article
LG  - English
EP  - 20151111
DP  - 2016 Feb
DC  - 20160128
YR  - 2016
UP  - 20160524
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26559414

<1020. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27131228
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Mazzone A
AU  - Bo M
AU  - Lucenti A
AU  - Galimberti S
AU  - Bellelli G
AU  - Annoni G
FA  - Mazzone, A
FA  - Bo, M
FA  - Lucenti, A
FA  - Galimberti, S
FA  - Bellelli, G
FA  - Annoni, G
IN  - Mazzone,A. School of Medicine and Surgery, University of Milano-Bicocca, Italy; Geriatric Unit, S. Gerardo Hospital, Monza, Italy.
IN  - Bo,M. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette, Torino, Italy.
IN  - Lucenti,A. School of Medicine and Surgery, University of Milano-Bicocca, Italy; Center of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Milan, Italy.
IN  - Galimberti,S. School of Medicine and Surgery, University of Milano-Bicocca, Italy; Center of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Milan, Italy.
IN  - Bellelli,G. School of Medicine and Surgery, University of Milano-Bicocca, Italy; Geriatric Unit, S. Gerardo Hospital, Monza, Italy; Milan Center for Neuroscience (Neuro-Mi), Milan, Italy. Electronic address: giuseppe.bellelli@unimib.it.
IN  - Annoni,G. School of Medicine and Surgery, University of Milano-Bicocca, Italy; Geriatric Unit, S. Gerardo Hospital, Monza, Italy; Milan Center for Neuroscience (Neuro-Mi), Milan, Italy.
TI  - The role of comprehensive geriatric assessment and functional status in evaluating the patterns of antithrombotic use among older people with atrial fibrillation.
SO  - Archives of Gerontology & Geriatrics. 65:248-54, 2016 Jul-Aug.
AS  - Arch Gerontol Geriatr. 65:248-54, 2016 Jul-Aug.
NJ  - Archives of gerontology and geriatrics
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 8214379, 7ax
SB  - Index Medicus
CP  - Netherlands
KW  - Antithrombotics;  Atrial fibrillation;  Comprehensive geriatric assessment;  Elderly
AB  - Aim of the study is to investigate the use of antithrombotic drugs in older patients with atrial fibrillation (AF) at the time of hospital discharge. We enrolled 399 >65 years old patients with AF consecutively admitted to our acute geriatric unit from September 2012 to February 2014. Utilization of antithrombotic drugs, comorbidities, functional, mental and nutritional status were evaluated through a comprehensive geriatric assessment (CGA). A Logistic regression model was used to assess variables associated with antithrombotic use. On admission, 198 patients (49.6%) used oral anticoagulants (OAC), 125 (21.3%) antiplatelets, 32 (8%) low weight molecular heparin (LMWH) and 44 (11%) none of them. At discharge the proportion of patients on OAC increased to 55.7%. Age>90years (OR=2.57, CI=1.28-5.16, p-value=0.008), severe functional impairment (OR=3.38, CI=1.63-7.01, p-value=0.001), polypharmacy (OR=2.07, CI=1.1-3.86, p-value=0.023), HAS-BLED score (OR=1.64, CI=1.09-2.47, p-value=0.019) and >1 OAC contraindication (OR=5.01, CI=2.68-9.34, p-value<0.001) were all associated with OAC underuse. In conclusion, OAC is underused in geriatric patients with AF, while antiplatelet, LMWH and no antithrombotic therapy are relatively overused. Factors associated with the decision to not prescribe OAC lie on a mix of clinical and geriatric variables, among which functional status is particularly relevant. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
ES  - 1872-6976
IL  - 0167-4943
DI  - S0167-4943(16)30072-3
DO  - http://dx.doi.org/10.1016/j.archger.2016.04.008
PT  - Journal Article
LG  - English
EP  - 20160413
DP  - 2016 Jul-Aug
DC  - 20160514
YR  - 2016
UP  - 20160516
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27131228

<1021. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26654778
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Takahashi K
AU  - Sasano T
AU  - Sugiyama K
AU  - Kurokawa J
AU  - Tamura N
AU  - Soejima Y
AU  - Sawabe M
AU  - Isobe M
AU  - Furukawa T
FA  - Takahashi, Kentaro
FA  - Sasano, Tetsuo
FA  - Sugiyama, Koji
FA  - Kurokawa, Junko
FA  - Tamura, Noriko
FA  - Soejima, Yurie
FA  - Sawabe, Motoji
FA  - Isobe, Mitsuaki
FA  - Furukawa, Tetsushi
IN  - Takahashi,Kentaro. Department of Cardiovascular Medicine, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Sasano,Tetsuo. Department of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address: sasano.bi@tmd.ac.jp.
IN  - Sugiyama,Koji. Department of Cardiovascular Medicine, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Kurokawa,Junko. Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Tamura,Noriko. Department of Cardiovascular Medicine, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Soejima,Yurie. Department of Molecular Pathology, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Sawabe,Motoji. Department of Molecular Pathology, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Isobe,Mitsuaki. Department of Cardiovascular Medicine, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
IN  - Furukawa,Tetsushi. Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
TI  - High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b.
SO  - Journal of Molecular & Cellular Cardiology. 90:38-46, 2016 Jan.
AS  - J Mol Cell Cardiol. 90:38-46, 2016 Jan.
NJ  - Journal of molecular and cellular cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - j72, 0262322
SB  - Index Medicus
CP  - England
KW  - Atrial fibrillation;  Electrical remodeling;  Gap junction;  Lipids;  MicroRNA
AB  - BACKGROUND: Lifestyle-related diseases, such as obesity and dyslipidemia are important risk factors for atrial fibrillation (AF). However, the underlying mechanism linking these diseases and AF has not been fully investigated.
AB  - METHODS: Adult male mice were fed a high-fat diet (HFD) or vehicle (NC) for 2 months. Electrocardiography and in vivo electrophysiological study were performed. Mice were then sacrificed for quantification of mRNA, microRNA, and protein in atria, in addition to histological analysis. Conduction velocity (CV) in right atrium was measured by optical mapping in Langendorff perfused hearts. Cultured atrial cardiomyocytes were treated with palmitate with or without a specific microRNA inhibitor. Twelve hours after stimulation, cells were lysed, and subjected to analysis with qPCR and Western blotting.
AB  - RESULTS: HFD mice showed prolonged P wave duration, increased inducibility of sustained atrial tachycardia, and reduced atrial CV than NC mice. HFD mice also showed increased expression in inflammatory cytokines, whereas fibrotic area and signals relating fibrosis were not changed. HFD mice demonstrated reduced expression of Cx40 in mRNA and protein levels, and its lateralized expression in atria. MicroRNA array analysis revealed that miR-27b expression was up-regulated in HFD mice, and luciferase assay confirmed the direct interaction between miR-27b and Cx40 3'UTR. In palmitate-stimulated atrial cardiomyocytes, miR-27b up-regulation and Cx40 down-regulation were observed, while expression of inflammatory cytokines was not altered. Inhibition of miR-27b with antisense oligonucleotides reversed the alteration caused by palmitate stimulation.
AB  - CONCLUSION: HFD may increase the vulnerability to atrial arrhythmia by down-regulation of Cx40 via miR-27b, rather than fibrosis, which is independent of inflammation.Copyright © 2015 Elsevier Ltd. All rights reserved.
ES  - 1095-8584
IL  - 0022-2828
DI  - S0022-2828(15)30138-3
DO  - http://dx.doi.org/10.1016/j.yjmcc.2015.11.034
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20151202
DP  - 2016 Jan
DC  - 20160119
YR  - 2016
UP  - 20160516
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26654778

<1022. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26584206
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Reed JL
AU  - Nery PB
AU  - Birnie DH
AU  - Tulloch HE
AU  - Pipe AL
FA  - Reed, Jennifer L
FA  - Nery, Pablo B
FA  - Birnie, David H
FA  - Tulloch, Heather E
FA  - Pipe, Andrew L
IN  - Reed,Jennifer L. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Reed,Jennifer L. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Nery,Pablo B. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Nery,Pablo B. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Birnie,David H. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Birnie,David H. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Tulloch,Heather E. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Tulloch,Heather E. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Pipe,Andrew L. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
IN  - Pipe,Andrew L. University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.
TI  - High-intensity interval training improves cardiovascular health, exercise capacity, and quality of life in permanent atrial fibrillation: a case study.
SO  - Applied Physiology, Nutrition, & Metabolism = Physiologie Appliquee, Nutrition et Metabolisme. 40(12):1321-3, 2015 Dec.
AS  - Appl Physiol Nutr Metab. 40(12):1321-3, 2015 Dec.
NJ  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101264333
SB  - Index Medicus
CP  - Canada
KW  - arrhythmias;  arythmies;  exercise physiology;  physiologie de l'exercice;  prevention;  prevention;  quality of life;  qualite de vie
AB  - Persons with permanent atrial fibrillation experience reduced exercise tolerance, weight gain, and an associated decline in overall health. We report on a 74-year-old man with permanent atrial fibrillation who underwent a 10-week high-intensity interval training program. Substantial improvements in heart rate, blood pressure, aerobic and functional capacity, and quality of life were observed. These are desirable as these patients are not candidates for other treatment options and more effective therapies for the treatment of atrial fibrillation are needed.
ES  - 1715-5320
IL  - 1715-5312
DO  - http://dx.doi.org/10.1139/apnm-2015-0356
PT  - Journal Article
NO  - UL1 TR001425 (United States NCATS NIH HHS)
LG  - English
EP  - 20150916
DP  - 2015 Dec
DC  - 20151125
YR  - 2015
RD  - 20160225
UP  - 20160516
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26584206

<1023. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26701875
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Mostofsky E
AU  - Johansen MB
AU  - Lundbye-Christensen S
AU  - Tjonneland A
AU  - Mittleman MA
AU  - Overvad K
FA  - Mostofsky, Elizabeth
FA  - Johansen, Martin Berg
FA  - Lundbye-Christensen, Soren
FA  - Tjonneland, Anne
FA  - Mittleman, Murray A
FA  - Overvad, Kim
IN  - Mostofsky,Elizabeth. Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
IN  - Johansen,Martin Berg. Department of Cardiology, Aalborg University Hospital, Denmark Unit of Clinical Biostatistics, Aalborg University Hospital, Denmark.
IN  - Lundbye-Christensen,Soren. Unit of Clinical Biostatistics, Aalborg University Hospital, Denmark Aalborg Atrial Fibrillation Study Group, Department of Cardiology, Aalborg University Hospital, Denmark.
IN  - Tjonneland,Anne. Danish Cancer Society Research Center, Copenhagen, Denmark.
IN  - Mittleman,Murray A. Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
IN  - Overvad,Kim. Department of Cardiology, Aalborg University Hospital, Denmark Section for Epidemiology, Department of Public Health, Aarhus University, Denmark ko@ph.au.dk.
TI  - Risk of atrial fibrillation associated with coffee intake: Findings from the Danish Diet, Cancer, and Health study.
SO  - European Journal of Preventive Cardiology. 23(9):922-30, 2016 Jun.
AS  - Eur J Prev Cardiolog. 23(9):922-30, 2016 Jun.
NJ  - European journal of preventive cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101564430
SB  - Index Medicus
CP  - England
KW  - Epidemiology;  arrhythmias;  clinical electrophysiology;  drugs;  nutrition
AB  - BACKGROUND: There have been discrepant findings on whether coffee consumption is associated with the rate of developing atrial fibrillation (AF).
AB  - METHODS AND RESULTS: We used data on 57,053 participants (27,178 men and 29,875 women) aged 50-64 years in the Danish Diet, Cancer and Health study. All participants provided information on coffee intake via food-frequency questionnaires at baseline. Incident AF was identified using nationwide registries. During a median follow-up of 13.5 years, 3415 AF events occurred. Compared with no intake, coffee consumption was inversely associated with AF incidence, with multivariable-adjusted hazard ratios of 0.93 (95% confidence interval [CI] 0.74-1.15) for more than none to <1 cup/day, 0.88 (95% CI 0.71-1.10) for 1 cup/day, 0.86 (95% CI 0.71-1.04) for 2-3 cups/day, 0.84 (95% CI 0.69-1.02) for 4-5 cups/day, 0.79 (95% CI 0.64-0.98) for 6-7 cups/day and 0.79 (95% CI 0.63-1.00) for >7 cups/day (p-linear trend=0.02).
AB  - CONCLUSIONS: In this large population-based cohort study, higher levels of coffee consumption were associated with a lower rate of incident AF.Copyright © The European Society of Cardiology 2015.
ES  - 2047-4881
IL  - 2047-4873
DO  - http://dx.doi.org/10.1177/2047487315624524
PT  - Journal Article
LG  - English
EP  - 20151223
DP  - 2016 Jun
DC  - 20160512
YR  - 2016
UP  - 20160513
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26701875

<1024. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27068670
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Faselis C
AU  - Kokkinos P
AU  - Tsimploulis A
AU  - Pittaras A
AU  - Myers J
AU  - Lavie CJ
AU  - Kyritsi F
AU  - Lovic D
AU  - Karasik P
AU  - Moore H
FA  - Faselis, Charles
FA  - Kokkinos, Peter
FA  - Tsimploulis, Apostolos
FA  - Pittaras, Andreas
FA  - Myers, Jonathan
FA  - Lavie, Carl J
FA  - Kyritsi, Fiorina
FA  - Lovic, Dragan
FA  - Karasik, Pamela
FA  - Moore, Hans
IN  - Faselis,Charles. Cardiology Division, Veterans Affairs Medical Center, Washington, DC; George Washington University School of Medicine, Washington, DC.
IN  - Kokkinos,Peter. Cardiology Division, Veterans Affairs Medical Center, Washington, DC; Georgetown University School of Medicine, Washington, DC; Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia. Electronic address: peter.kokkinos@va.gov.
IN  - Tsimploulis,Apostolos. Cardiology Division, Veterans Affairs Medical Center, Washington, DC.
IN  - Pittaras,Andreas. Cardiology Division, Veterans Affairs Medical Center, Washington, DC.
IN  - Myers,Jonathan. Veterans Affairs Palo Alto Health Care System, Cardiology Division, Palo Alto, CA; Stanford University, Stanford, CA.
IN  - Lavie,Carl J. Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-the University Queensland School of Medicine, New Orleans, LA.
IN  - Kyritsi,Fiorina. Cardiology Division, Veterans Affairs Medical Center, Washington, DC.
IN  - Lovic,Dragan. Cardiology Division, Veterans Affairs Medical Center, Washington, DC.
IN  - Karasik,Pamela. Cardiology Division, Veterans Affairs Medical Center, Washington, DC; George Washington University School of Medicine, Washington, DC; Georgetown University School of Medicine, Washington, DC.
IN  - Moore,Hans. Cardiology Division, Veterans Affairs Medical Center, Washington, DC; Georgetown University School of Medicine, Washington, DC.
TI  - Exercise Capacity and Atrial Fibrillation Risk in Veterans: A Cohort Study.
SO  - Mayo Clinic Proceedings. 91(5):558-66, 2016 May.
AS  - Mayo Clin Proc. 91(5):558-66, 2016 May.
NJ  - Mayo Clinic proceedings
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 0405543, lly
SB  - Core Clinical Journals (AIM)
SB  - Index Medicus
CP  - England
AB  - OBJECTIVE: To assess the association between exercise capacity and the risk of developing atrial fibrillation (AF).
AB  - PATIENTS AND METHODS: A symptom-limited exercise tolerance test was conducted to assess exercise capacity in 5962 veterans (mean age, 56.8+/-11.0 years) from the Veterans Affairs Medical Center, Washington, DC. None had evidence of AF or ischemia at the time of or before undergoing their exercise tolerance test. We established 4 fitness categories based on age-stratified quartiles of peak metabolic equivalent task (MET) achieved: least fit (4.9+/-1.10 METs; n=1446); moderately fit (6.7+/-1.0 METs; n=1490); fit (7.9+/-1.0 METs; n=1585), and highly fit (9.3+/-1.2 METs; n=1441). Multivariable Cox proportional hazards regression models were used to compare the AF-exercise capacity association between fitness categories.
AB  - RESULTS: During a median follow-up period of 8.3 years, 722 (12.1%) individuals developed AF (14.5 per 1000 person-years; 95% CI, 13.9-15.9 per 1000 person-years). Exercise capacity was inversely related to AF incidence. The risk was 21% lower (hazard ratio, 0.79; 95% CI, 0.76-0.82) for each 1-MET increase in exercise capacity. Compared with the least fit individuals, hazard ratios were 0.80 (95% CI, 0.67-0.97) for moderately fit individuals, 0.55 (95% CI, 0.45-0.68) for fit individuals, and 0.37 (95% CI, 0.29-0.47) for highly fit individuals. Similar trends were observed in those younger than 65 years and those 65 years or older.
AB  - CONCLUSION: Increased fitness is inversely and independently associated with the reduced risk of developing AF. The decrease in risk was graded and precipitous with only modest increases in exercise capacity. These findings counter previous suggestions that even moderate increases in physical activity, as recommended by national and international guidelines, increase the risk of AF, with marked protection against AF noted with increasing levels of fitness.Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
ES  - 1942-5546
IL  - 0025-6196
DI  - S0025-6196(16)30006-4
DO  - http://dx.doi.org/10.1016/j.mayocp.2016.03.002
PT  - Journal Article
LG  - English
EP  - 20160408
DP  - 2016 May
DC  - 20160506
YR  - 2016
UP  - 20160509
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27068670

<1025. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27068668
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Kapa S
AU  - Asirvatham SJ
FA  - Kapa, Suraj
FA  - Asirvatham, Samuel J
IN  - Kapa,Suraj. Mayo Clinic, Rochester, MN.
IN  - Asirvatham,Samuel J. Mayo Clinic, Rochester, MN. Electronic address: Asirvatham.samuel@mayo.edu.
TI  - A MET a Day Keeps Arrhythmia at Bay: The Association Between Exercise or Cardiorespiratory Fitness and Atrial Fibrillation.
SO  - Mayo Clinic Proceedings. 91(5):545-50, 2016 May.
AS  - Mayo Clin Proc. 91(5):545-50, 2016 May.
NJ  - Mayo Clinic proceedings
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 0405543, lly
SB  - Core Clinical Journals (AIM)
SB  - Index Medicus
CP  - England
ES  - 1942-5546
IL  - 0025-6196
DI  - S0025-6196(16)30029-5
DO  - http://dx.doi.org/10.1016/j.mayocp.2016.03.003
PT  - Editorial
LG  - English
EP  - 20160408
DP  - 2016 May
DC  - 20160506
YR  - 2016
UP  - 20160509
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27068668

<1026. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26123830
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Voss F
AU  - Schueler M
AU  - Lauterbach M
AU  - Bauer A
AU  - Katus HA
AU  - Becker R
FA  - Voss, Frederik
FA  - Schueler, Melanie
FA  - Lauterbach, Michael
FA  - Bauer, Alexander
FA  - Katus, Hugo A
FA  - Becker, Ruediger
IN  - Voss,Frederik. Department of Cardiology, Krankenhaus der Barmherzigen Brueder Trier, Nordallee 1, 54290, Trier, Germany. f.voss@bk-trier.de.
IN  - Schueler,Melanie. Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
IN  - Lauterbach,Michael. Department of Cardiology, Krankenhaus der Barmherzigen Brueder Trier, Nordallee 1, 54290, Trier, Germany.
IN  - Bauer,Alexander. Department of Cardiology, Diakonie-Klinikum Schwaebisch Hall, Diakoniestr. 10, 74523, Schwaebisch Hall, Germany.
IN  - Katus,Hugo A. Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
IN  - Becker,Ruediger. Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
TI  - Safety of symptom-limited exercise testing in a big cohort of a modern ICD population.
SO  - Clinical Research in Cardiology. 105(1):53-8, 2016 Jan.
AS  - Clin. res. cardiol.. 105(1):53-8, 2016 Jan.
NJ  - Clinical research in cardiology : official journal of the German Cardiac Society
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101264123
SB  - Index Medicus
CP  - Germany
KW  - Exercise test;  ICD;  Ventricular arrhythmias
AB  - BACKGROUND: Exercise may predispose to ventricular arrhythmias especially in patients with congestive heart failure. As therapy with implanted cardioverter-defibrillators (ICDs) has become standard medical care, there is an emerging number of exercise tests that need to be performed in patients with ICDs. In contrast, little is known about the safety of symptom-limited exercise testing in these patients.
AB  - METHODS AND RESULTS: 400 ICD patients performed symptom-limited exercise treadmill testing. 200 patients performed a ramp protocol with an initial workload of 0 W increased by 15 W every minute. Another 200 ICD patients did a slightly modified ramp protocol with again an initial workload of 0 W but with an increased capacity of 15 W every 2 min. The study population consists mainly of patients with ischemic (63%) and non-ischemic (34%) heart disease. Atrial fibrillation was present in 16% of the subjects. The mean ejection fraction was 28 +/- 8, and 78% of the patients had an ejection fraction below 30%. In this cohort of patients, no sustained ventricular arrhythmias and no deaths occurred during or after exercise testing. No inappropriate shock delivery was observed. The modified ramp protocol resulted in a prolonged exercise time with equal exercise capacity but does not result in an enhanced susceptibility for ventricular arrhythmias.
AB  - CONCLUSIONS: Symptom-limited exercise treadmill testing in heart failure patients with ICDs is a safe procedure. The use of a ramp protocol is sufficient in terms of safety and is easy to perform in general practice. The exercise duration in heart failure patients with ICDs does not predict serious adverse events.
ES  - 1861-0692
IL  - 1861-0684
DO  - http://dx.doi.org/10.1007/s00392-015-0885-5
PT  - Journal Article
LG  - English
EP  - 20150630
DP  - 2016 Jan
DC  - 20160114
YR  - 2016
UP  - 20160509
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26123830

<1027. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26598510
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Rudolph TK
AU  - Ravekes T
AU  - Klinke A
AU  - Friedrichs K
AU  - Mollenhauer M
AU  - Pekarova M
AU  - Ambrozova G
AU  - Martiskova H
AU  - Kaur JJ
AU  - Matthes B
AU  - Schwoerer A
AU  - Woodcock SR
AU  - Kubala L
AU  - Freeman BA
AU  - Baldus S
AU  - Rudolph V
FA  - Rudolph, Tanja K
FA  - Ravekes, Thorben
FA  - Klinke, Anna
FA  - Friedrichs, Kai
FA  - Mollenhauer, Martin
FA  - Pekarova, Michaela
FA  - Ambrozova, Gabriela
FA  - Martiskova, Hana
FA  - Kaur, Jatinder-Jit
FA  - Matthes, Bianca
FA  - Schwoerer, Alex
FA  - Woodcock, Steven R
FA  - Kubala, Lukas
FA  - Freeman, Bruce A
FA  - Baldus, Stephan
FA  - Rudolph, Volker
IN  - Rudolph,Tanja K. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
IN  - Ravekes,Thorben. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
IN  - Klinke,Anna. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany International Clinical Research Center-Center of Biomolecular and Cellular Engineering, St Anne's University Hospital Brno, Brno, Czech Republic.
IN  - Friedrichs,Kai. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
IN  - Mollenhauer,Martin. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
IN  - Pekarova,Michaela. Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. I, Brno, Czech Republic.
IN  - Ambrozova,Gabriela. Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. I, Brno, Czech Republic.
IN  - Martiskova,Hana. Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. I, Brno, Czech Republic.
IN  - Kaur,Jatinder-Jit. Department of Cardiology, University Heart Center Hamburg, University Hospital Eppendorf, Hamburg, Germany.
IN  - Matthes,Bianca. Department of Cardiology, University Heart Center Hamburg, University Hospital Eppendorf, Hamburg, Germany.
IN  - Schwoerer,Alex. Department of Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany DZHK (German Centre for Cardiovascular Research)-Hamburg/Kiel/Luebeck, Hamburg, Germany.
IN  - Woodcock,Steven R. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
IN  - Kubala,Lukas. International Clinical Research Center-Center of Biomolecular and Cellular Engineering, St Anne's University Hospital Brno, Brno, Czech Republic Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. I, Brno, Czech Republic.
IN  - Freeman,Bruce A. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
IN  - Baldus,Stephan. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
IN  - Rudolph,Volker. Department of Cardiology, University Heart Center Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany volker.rudolph@uk.koeln.de.
TI  - Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.
SO  - Cardiovascular Research. 109(1):174-84, 2016 Jan 1.
AS  - Cardiovasc Res. 109(1):174-84, 2016 Jan 1.
NJ  - Cardiovascular research
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - cor, 0077427
SB  - Index Medicus
CP  - England
KW  - Atrial fibrillation;  Fibrosis;  Nitro-fatty acids;  Reactive oxygen species
AB  - AIM: Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be useful as drug candidates. Herein we investigate whether an exemplary nitro-fatty acid can limit atrial fibrosis and AF.
AB  - METHODS AND RESULTS: Wild-type C57BL6/J mice were treated for 2 weeks with angiotensin II (AngII) and vehicle or nitro-oleic acid (10-nitro-octadec-9-enoic acid, OA-NO2, 6 mg/kg body weight) via subcutaneous osmotic minipumps. OA-NO2 significantly inhibited atrial fibrosis and depressed vulnerability for AF during right atrial electrophysiological stimulation to levels observed for AngII-naive animals. Left atrial epicardial mapping studies demonstrated preservation of conduction homogeneity by OA-NO2. The protection from fibrotic remodelling was mediated by suppression of Smad2-dependent myofibroblast transdifferentiation and inhibition of Nox2-dependent atrial superoxide formation.
AB  - CONCLUSION: OA-NO2 potently inhibits atrial fibrosis and subsequent AF. Nitro-fatty acids and possibly other lipid electrophiles thus emerge as potential therapeutic agents for AF, either by increasing endogenous levels through dietary modulation or by administration as synthetic drugs.Copyright Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.
ES  - 1755-3245
IL  - 0008-6363
DO  - http://dx.doi.org/10.1093/cvr/cvv254
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
NO  - P01-HL103455 (United States NHLBI NIH HHS)
NO  - R01-HL058115 (United States NHLBI NIH HHS)
NO  - R01-HL64937 (United States NHLBI NIH HHS)
NO  - R37 HL058115 (United States NHLBI NIH HHS)
LG  - English
EP  - 20151123
DP  - 2016 Jan 1
DC  - 20151229
YR  - 2016
RD  - 20160429
UP  - 20160502
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26598510

<1028. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26077474
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Robbins J
AU  - Petrone AB
AU  - Gaziano JM
AU  - Djousse L
FA  - Robbins, Jeremy
FA  - Petrone, Andrew B
FA  - Gaziano, J Michael
FA  - Djousse, Luc
IN  - Robbins,Jeremy. Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center, Boston Veterans Affairs Healthcare System, Boston, MA, USA.
IN  - Petrone,Andrew B. Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
IN  - Gaziano,J Michael. Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center, Boston Veterans Affairs Healthcare System, Boston, MA, USA.
IN  - Djousse,Luc. Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center, Boston Veterans Affairs Healthcare System, Boston, MA, USA. Electronic address: ldjousse@rics.bwh.harvard.edu.
TI  - Dietary vitamin D and risk of heart failure in the Physicians' Health Study.
SO  - Clinical Nutrition. 35(3):650-3, 2016 Jun.
AS  - Clin Nutr. 35(3):650-3, 2016 Jun.
NJ  - Clinical nutrition (Edinburgh, Scotland)
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - c3x, 8309603
OI  - Source: NLM. NIHMS700387 [Available on 06/01/17]
OI  - Source: NLM. PMC4618265 [Available on 06/01/17]
SB  - Index Medicus
CP  - England
KW  - Cardiovascular disease;  Diet;  Epidemiology;  Heart failure;  Vitamin D
AB  - BACKGROUND: Experimental studies have demonstrated the role of vitamin D in key pathways related to cardiovascular health. While several studies have investigated the impact of vitamin D therapy on outcomes in subjects with prevalent heart failure, limited research exists on the relationship of dietary vitamin D consumption with the risk of heart failure. Thus, we sought to investigate whether dietary vitamin D consumption was associated with a lower risk of incident heart failure in a large prospective cohort of male physicians.
AB  - METHODS AND RESULTS: We prospectively studied 19,635 males from the Physicians' Health Study. Dietary vitamin D information was obtained from a baseline food frequency questionnaire, and heart failure information was obtained by questionnaire and validated in a subsample. Mean age was 66.4 years. Median dietary vitamin D consumption was 200.4 IU and only 2.3% of the subjects used vitamin D supplements. After an average follow-up of 9.3 years, there were 858 new cases of heart failure identified. Higher intake of dietary vitamin D was not associated with incident heart failure in a multivariable adjusted model: hazard ratios (95% CI) of incident heart failure were 1.0 (reference), 1.29 (1.04-1.60), 1.17 (0.94-1.46), 1.22 (0.98-1.53), and 1.16 (0.92-1.46) from lowest to highest age- and energy-adjusted vitamin D quintile, respectively, after adjusting for age, BMI, race, exercise, alcohol use, smoking, calories, and prevalent atrial fibrillation (p for linear trend = 0.64).
AB  - CONCLUSIONS: These data are consistent with a lack of an association between dietary vitamin D and incident heart failure in this population of professionally-employed middle-aged males.Copyright Published by Elsevier Ltd.
ES  - 1532-1983
IL  - 0261-5614
DI  - S0261-5614(15)00121-1
DO  - http://dx.doi.org/10.1016/j.clnu.2015.04.011
PT  - Journal Article
NO  - R01 CA034944 (United States NCI NIH HHS)
NO  - R01 CA034944-03 (United States NCI NIH HHS)
NO  - R01 CA040360 (United States NCI NIH HHS)
NO  - R01 CA097193 (United States NCI NIH HHS)
NO  - R01 HL026490 (United States NHLBI NIH HHS)
NO  - R01 HL026490-03 (United States NHLBI NIH HHS)
NO  - R01 HL034595 (United States NHLBI NIH HHS)
NO  - R01 HL034595-07 (United States NHLBI NIH HHS)
NO  - R21 HL088081 (United States NHLBI NIH HHS)
LG  - English
EP  - 20150422
DP  - 2016 Jun
DC  - 20160426
YR  - 2016
RD  - 20160427
UP  - 20160502
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26077474

<1029. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27115075
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Palermo P
AU  - Magri D
AU  - Sciomer S
AU  - Stefanini E
AU  - Agalbato C
AU  - Compagnino E
AU  - Chircu CM
AU  - Maffessanti F
AU  - Teodoru M
AU  - Agostoni P
FA  - Palermo, Pietro
FA  - Magri, Damiano
FA  - Sciomer, Susanna
FA  - Stefanini, Elisa
FA  - Agalbato, Cecilia
FA  - Compagnino, Elisa
FA  - Chircu, Cristina M
FA  - Maffessanti, Francesco
FA  - Teodoru, Minodora
FA  - Agostoni, Piergiuseppe
IN  - Palermo,Pietro. Centro Cardiologico Monzino (Drs Palermo, Stefanini, Agalbato, Compagnino, Maffessanti, and Agostoni), IRCCS, Milan, Italy; Dipartimento di Medicina Clinica e Molecolare (Dr Magri), Universita degli Studi di Roma "La Sapienza," Rome, Italy; Dipartimento di Scienze Cardiovascolari (Dr Sciomer), Respiratorie, Anestesiologiche, Nefrologiche e Geriatriche, "La Sapienza," Rome, Italy; Emergency Clinical Hospital Sibiu (Dr Chircu), Sibiu, Romania; Faculty of Medicine (Dr Teodoru), "Lucian Blaga" University, Sibiu, Romania; and Department of Clinical Sciences and Community Health (Dr Agostoni), University of Milan, Milan, Italy.
TI  - Delayed Anaerobic Threshold in Heart Failure Patients With Atrial Fibrillation.
SO  - Journal of Cardiopulmonary Rehabilitation & Prevention. 36(3):174-9, 2016 May-Jun.
AS  - J Mol Signal. 36(3):174-9, 2016 May-Jun.
NJ  - Journal of cardiopulmonary rehabilitation and prevention
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - 101291247
SB  - Index Medicus
CP  - United States
AB  - PURPOSE: To assess whether atrial fibrillation (AF) in heart failure (HF) affects oxygen uptake at anaerobic threshold ((Equation is included in full-text article.)O2 AT) and heart rate (HR) kinetics.
AB  - METHODS: A total of 15 patients with HF and AF and 18 with HF and sinus rhythm (SR) performed a maximal incremental and 2 constant workload cycle ergometer cardiopulmonary exercise tests (below and above AT, at 25% and 75% of maximal workload, respectively). At constant workload tests, kinetics of (Equation is included in full-text article.)O2 and HR were assessed by calculating time constant (tau).
AB  - RESULTS: HF patients with AF showed a similar peak (Equation is included in full-text article.)O2 to those with SR (16.7 +/- 4.5 mL/kg/min vs 16.6 +/- 3.9 mL/kg/min). However, (Equation is included in full-text article.)O2 AT (11.3 +/- 2.9 mL/kg/min vs 9.3 +/- 2.8 mL/kg/min; P < .05), peak HR (149 +/- 18.8 bpm vs 116.4 +/- 20.4 bpm; P < .001), HR AT (125.3 +/- 19.1 bpm vs 90.3 +/- 15.5 bpm; P < .001), and HR increase during exercise were greater in HF patients with AF. Finally, tauHR and tau(Equation is included in full-text article.)O2 below and above AT were not significantly different.
AB  - CONCLUSIONS: In HF patients with AF, despite a similar peak (Equation is included in full-text article.)O2 compared with patients with HF and SR, (Equation is included in full-text article.)O2 AT is higher because of a higher HR and a greater HR increase during exercise. One postulated mechanism would be a greater cardiac output increase at the beginning of exercise in HF patients with AF. The delayed AT generates uncertainty about the meaning of a (Equation is included in full-text article.)O2 value at AT in HF patients with AF, because a higher AT is usually associated with better performance and a better prognosis.
ES  - 1932-751X
IL  - 1932-7501
DO  - http://dx.doi.org/10.1097/HCR.0000000000000159
PT  - Journal Article
LG  - English
DP  - 2016 May-Jun
DC  - 20160427
YR  - 2016
UP  - 20160428
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27115075

<1030. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25787210
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Fabjan TH
AU  - Hojs R
FA  - Fabjan, Tanja Hojs
FA  - Hojs, Radovan
IN  - Fabjan,Tanja Hojs. Department of Neurology, University Clinical Centre Maribor, Ljubljanska 5, 2000, Maribor, Slovenia. tanja.hojs@ukc-mb.si.
IN  - Fabjan,Tanja Hojs. Faculty of Medicine, University of Maribor, Maribor, Slovenia. tanja.hojs@ukc-mb.si.
IN  - Hojs,Radovan. Clinic for Internal Medicine, Department of Nephrology, University Clinical Centre Maribor, Maribor, Slovenia.
IN  - Hojs,Radovan. Faculty of Medicine, University of Maribor, Maribor, Slovenia.
TI  - Ischemic stroke: the impact of renal dysfunction on 1-year mortality.
SO  - Wiener Klinische Wochenschrift. 127 Suppl 5:S175-80, 2015 Dec.
AS  - Wien Klin Wochenschr. 127 Suppl 5:S175-80, 2015 Dec.
NJ  - Wiener klinische Wochenschrift
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - xop, 21620870r
SB  - Index Medicus
CP  - Austria
KW  - Atherosclerosis;  Ischemic stroke;  Mortality;  Renal dysfunction;  Risk factors
AB  - BACKGROUND: Atherosclerosis is accelerated in patients with different stages of chronic renal failure. Renal dysfunction predicts mortality in patients with myocardial infarction and congestive heart failure. Less is known about the impact of renal dysfunction on mortality after ischemic stroke. The aim of the study was to investigate the impact of renal dysfunction on 1-year mortality.
AB  - PATIENTS AND METHODS: All 390 patients (207 men and 183 women) suffered from ischemic stroke in 1-year period were included in our study. Telephonic follow-up after 1 year was performed. The mean age of our patients was 71.0+/-11.6 years, ranged from 36 to 96 years. Glomerular filtration rate (GFR) was calculated according to abbreviated Modification of Diet in Renal Disease formula. At admission and at discharge National Institutes of Health Stroke Scale (NIHSS) were performed.
AB  - RESULTS: The mean GFR in our patients was 66.0+/-20.68 ml/min/1.73 m(2). There were 123 (31.5%) deaths in 1-year period. Patients who died were older (P<0.001), had higher NIHSS at admission and at discharge (both P<0.001), higher high-sensitive C-reactive protein (P=0.002), lower albumin (P<0.001), lower GFR (P=0.044), had more frequent atrial fibrillation (P<0.001), and were less frequent actual smokers (P=0.003). No differences in presence of diabetes and hypertension, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides between patients who died or survived were found. With Cox multivariable regression analysis age (P=0.037), gender (P=0.005), NIHSS at admission (P=0.005) and discharge (P<0.001), albumin (P=0.005) and also GFR (P=0.025) were predictors of 1-year mortality.
AB  - CONCLUSIONS: In patients with ischemic stroke, renal dysfunction (decreased GFR) was associated with 1-year mortality. GFR was independent predictor of mortality.
ES  - 1613-7671
IL  - 0043-5325
DO  - http://dx.doi.org/10.1007/s00508-015-0705-y
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20150319
DP  - 2015 Dec
DC  - 20151224
YR  - 2015
UP  - 20160420
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25787210

<1031. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26694887
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Hussein A
AU  - Saliba W
AU  - Wazni OM
FA  - Hussein, Ayman
FA  - Saliba, Walid
FA  - Wazni, Oussama M
IN  - Hussein,Ayman. Cardiac Electrophysiology and Pacing, Cleveland Clinic, Cleveland, OH, USA.
IN  - Saliba,Walid. Medical Director, Center for Atrial Fibrillation, Cleveland Clinic, Cleveland, OH, USA.
IN  - Wazni,Oussama M. Director, Outpatient Electrophysiology Department, Cleveland Clinic, Cleveland, OH, USA.
IN  - Wazni,Oussama M. Co-Director, Ventricular Arrhythmia Center, Cleveland Clinic, Cleveland, OH, USA.
IN  - Wazni,Oussama M. Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA. E-mail: waznio@ccf.org.
TI  - Evolving strategies to prevent stroke and thromboembolism in nonvalvular atrial fibrillation. [Review]
SO  - Cleveland Clinic Journal of Medicine. 82(12 Suppl 2):S11-6, 2015 Dec.
AS  - Cleve Clin J Med. 82(12 Suppl 2):S11-6, 2015 Dec.
NJ  - Cleveland Clinic journal of medicine
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - dbn, 8703441
SB  - Index Medicus
CP  - United States
AB  - Stroke prevention in patients with nonvalvular atrial fibrillation relies on an assessment of the individual risks for stroke and bleeding. Patients at high risk for stroke are candidates for anticoagulant therapy. Anticoagulants, however, have substantial bleeding risks that must be weighed in the therapeutic decision. Warfarin has been the traditional choice, but the recently introduced novel oral anticoagulants offer similar efficacy with less bleeding risk. Additionally, they do not require monitoring and have fewer drug interactions and dietary restrictions than warfarin. Several devices, which isolate the left atrial appendage, have become available as treatment options for patients with elevated risks of both thromboembolism and bleeding complications. Copyright © 2015 Cleveland Clinic.
ES  - 1939-2869
IL  - 0891-1150
DO  - http://dx.doi.org/10.3949/ccjm.82.s2.03
PT  - Journal Article
PT  - Review
LG  - English
DP  - 2015 Dec
DC  - 20151223
YR  - 2015
UP  - 20160415
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26694887

<1032. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26569363
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Kato Y
AU  - Suzuki S
AU  - Kano H
AU  - Semba H
AU  - Matsuno S
AU  - Takai H
AU  - Otsuka T
AU  - Uejima T
AU  - Oikawa Y
AU  - Nagashima K
AU  - Kirigaya H
AU  - Sagara K
AU  - Kunihara T
AU  - Yajima J
AU  - Sawada H
AU  - Aizawa T
AU  - Yamashita T
FA  - Kato, Yuko
FA  - Suzuki, Shinya
FA  - Kano, Hiroto
FA  - Semba, Hioaki
FA  - Matsuno, Shunsuke
FA  - Takai, Hideaki
FA  - Otsuka, Takayuki
FA  - Uejima, Tokuhisa
FA  - Oikawa, Yuji
FA  - Nagashima, Kazuyuki
FA  - Kirigaya, Hajime
FA  - Sagara, Koichi
FA  - Kunihara, Takashi
FA  - Yajima, Junji
FA  - Sawada, Hitoshi
FA  - Aizawa, Tadanori
FA  - Yamashita, Takeshi
IN  - Kato,Yuko. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan. Electronic address: kimuchi@nms.ac.jp.
IN  - Suzuki,Shinya. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Kano,Hiroto. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Semba,Hioaki. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Matsuno,Shunsuke. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Takai,Hideaki. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Otsuka,Takayuki. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Uejima,Tokuhisa. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Oikawa,Yuji. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Nagashima,Kazuyuki. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Kirigaya,Hajime. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Sagara,Koichi. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Kunihara,Takashi. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Yajima,Junji. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Sawada,Hitoshi. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Aizawa,Tadanori. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
IN  - Yamashita,Takeshi. Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.
TI  - Prognostic significance of exercise capacity and resting heart rate: Comparison between atrial fibrillation and sinus rhythm.
SO  - International Journal of Cardiology. 203:561-3, 2016 Jan 15.
AS  - Int J Cardiol. 203:561-3, 2016 Jan 15.
NJ  - International journal of cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - gqw, 8200291
SB  - Index Medicus
CP  - Netherlands
KW  - Atrial fibrillation;  Exercise capacity;  Heart failure hospitalization;  Peak VO(2);  Resting heart rate;  Sinus rhythm
ES  - 1874-1754
IL  - 0167-5273
DI  - S0167-5273(15)30796-8
DO  - http://dx.doi.org/10.1016/j.ijcard.2015.10.227
PT  - Letter
LG  - English
EP  - 20151030
DP  - 2016 Jan 15
DC  - 20151222
YR  - 2016
UP  - 20160413
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26569363

<1033. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26512836
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Zhou Q
AU  - Zhou X
AU  - TuEr-Hong ZL
AU  - Wang H
AU  - Yin T
AU  - Li Y
AU  - Zhang L
AU  - Lu Y
AU  - Xing Q
AU  - Zhang J
AU  - Yang Y
AU  - Tang B
FA  - Zhou, Qina
FA  - Zhou, Xianhui
FA  - TuEr-Hong, ZuKe-la
FA  - Wang, Hongli
FA  - Yin, Tingting
FA  - Li, Yaodong
FA  - Zhang, Ling
FA  - Lu, Yanmei
FA  - Xing, Qiang
FA  - Zhang, Jianghua
FA  - Yang, Yining
FA  - Tang, Baopeng
IN  - Zhou,Qina. Clinical Medicine, Postdoctoral Scientific Research Station, Xinjiang Medical University, Urumqi, China.
IN  - Zhou,Xianhui. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - TuEr-Hong,ZuKe-la. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Wang,Hongli. Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Yin,Tingting. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Li,Yaodong. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Zhang,Ling. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Lu,Yanmei. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Xing,Qiang. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Zhang,Jianghua. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
IN  - Yang,Yining. Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address: yagnyin5126@163.com.
IN  - Tang,Baopeng. Heart Center, Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address: tangbaopeng1111@163.com.
TI  - Renal sympathetic denervation suppresses atrial fibrillation induced by acute atrial ischemia/infarction through inhibition of cardiac sympathetic activity.
SO  - International Journal of Cardiology. 203:187-95, 2016 Jan 15.
AS  - Int J Cardiol. 203:187-95, 2016 Jan 15.
NJ  - International journal of cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - gqw, 8200291
SB  - Index Medicus
CP  - Netherlands
KW  - Atrial fibrillation;  Infarction;  Ischemia;  Renal sympathetic denervation;  Sympathetic activity
AB  - OBJECTIVE: This study aims to explore the effects of renal sympathetic denervation (RSD) on atrial fibrillation (AF) inducibility and sympathetic activity induced by acute atrial ischemia/infarction.
AB  - METHODS: Acute ischemia/infarction was induced in 12 beagle dogs by ligating coronary arteries that supply the atria. Six dogs in the sham-RSD group did not undergo RSD, and six dogs without coronary artery ligation served as controls. AF induction rate, sympathetic discharge, catecholamine concentration and densities of tyrosine hydroxylase-positive nerves were measured.
AB  - RESULTS: Acute atrial ischemia/infarction resulted in a significant increase of AF induction rate, which was decreased by RSD compared to controls (P<0.05). The root-mean-square peak value, peak area and number of sympathetic discharges were significantly augmented by atrial ischemia relative to the baseline and control (P<0.05). The number of sympathetic discharges was significantly reduced in the RSD group, compared to the control and sham-RSD groups (P<0.05). Norepinephrine and epinephrine concentrations in the atria, ventricle and kidney were elevated by atrial ischemia/infarction, but were reduced by RSD (P<0.05).
AB  - CONCLUSIONS: Sympathetic hyperactivity was associated with pacing-induced AF after acute atrial ischemia/infarction. RSD has the potential to reduce the incidence of new-onset AF after acute atrial ischemia/infarction. The inhibition of cardiac sympathetic activity by RSD may be one of the major underlying mechanisms for the marked reduction of AF inducibility.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
ES  - 1874-1754
IL  - 0167-5273
DI  - S0167-5273(15)30684-7
DO  - http://dx.doi.org/10.1016/j.ijcard.2015.10.120
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20151017
DP  - 2016 Jan 15
DC  - 20151222
YR  - 2016
UP  - 20160413
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26512836

<1034. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26668285
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Bosomworth NJ
FA  - Bosomworth, N John
IN  - Bosomworth,N John. Dr Bosomworth is Honorary Lecturer in the Department of Family Practice at the University of British Columbia in Vancouver. jbosomworth@gmail.com.
TI  - Atrial fibrillation and physical activity: Should we exercise caution?.
SO  - Canadian Family Physician. 61(12):1061-70, 2015 Dec.
AS  - Can Fam Physician. 61(12):1061-70, 2015 Dec.
NJ  - Canadian family physician Medecin de famille canadien
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - blo, 0120300
OI  - Source: NLM. PMC4677942
SB  - Index Medicus
CP  - Canada
AB  - OBJECTIVE: To review the evidence on the effects of various levels of physical activity (PA) on the incidence of atrial fibrillation (AF) in both the general population and in endurance athletes.
AB  - DATA SOURCES: A PubMed search was done initially using the MeSH headings or text words (with the search-field descriptor TIAB [title and abstract]) atrial fibrillation and exercise or physical activity or athlet* or sport*, without additional filters. Conclusions regarding quality and strength of evidence were based on the GRADE (grading of recommendations, assessment, development, and evaluation) system.
AB  - STUDY SELECTION: No interventional studies were available. Observational studies were therefore considered acceptable, and, although larger long-term prospective cohort studies were preferred, case-control or cross-sectional trials were also included in this review.
AB  - SYNTHESIS: Available evidence suggests a dose-response association linking increased exercise levels with reduced incident AF in women. The same is true in men at low and moderate levels of exertional activity. In men only, high levels of PA are associated with increased risk of AF in most, but not all, studies. This risk is moderate, with a hazard ratio of 1.29 in one of the better studies. The risk of AF for most people who exercise regularly is lower than that of a matched sedentary population.
AB  - CONCLUSION: Atrial fibrillation is probably less common as PA increases, with a demonstrable dose-response relationship. Exercise at any level should be promoted for its effect on physical well-being and mortality reduction. In men exercising at high levels, beneficial effects on AF might be lost and risk might exceed that of the sedentary population; however, the evidence is neither robust nor consistent. These men should be made aware of this modest increase in risk should they choose to continue to engage in high levels of PA.Copyright© the College of Family Physicians of Canada.
ES  - 1715-5258
IL  - 0008-350X
PT  - Journal Article
LG  - English
DP  - 2015 Dec
DC  - 20151215
YR  - 2015
RD  - 20151229
UP  - 20160401
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26668285

<1035. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26593171
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Dilber D
AU  - Cerkez-Habek J
AU  - Baric H
AU  - Gradiser M
FA  - Dilber, Dario
FA  - Cerkez-Habek, Jasna
FA  - Baric, Hrvoje
FA  - Gradiser, Marina
IN  - Dilber,Dario. Department of Cardiology, County Hospital Cakovec, Cakovec, Croatia. E-mail. dario.dilber@gmail.com.
TI  - Atrial fibrillation cardioversion following acupuncture.
SO  - Saudi Medical Journal. 36(11):1351-3, 2015 Nov.
AS  - Saudi Med J. 36(11):1351-3, 2015 Nov.
NJ  - Saudi medical journal
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - dyw, 7909441
OI  - Source: NLM. PMC4673375
SB  - Index Medicus
CP  - Saudi Arabia
AB  - Atrial fibrillation (AF) is the most common arrhythmia and it is an independent risk for serious events. Acupuncture has been growing in popularity in the West, and there are reports of its benefits in treating AF. We report a 57-year-old man who was admitted after having an allergic reaction to amiodarone administered to treat paroxysmal AF with fast ventricular response. Cardioversion with intravenous propafenone was uneventful. Before an attempt of electric cardioversion, he was treated with acupuncture as additional therapy to peroral propafenone. After acupuncture treatment consisting of 10 treatments during 30 days period, both immediate cardioversion to sinus rhythm and no paroxysmal AF during 30 days period were recorded.
IS  - 0379-5284
IL  - 0379-5284
DO  - http://dx.doi.org/10.15537/smj.2015.11.12891
PT  - Journal Article
LG  - English
DP  - 2015 Nov
DC  - 20151123
YR  - 2015
RD  - 20151214
UP  - 20160304
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26593171

<1036. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26386926
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Giuseppe C
AU  - Chiara F
AU  - Giuseppe R
AU  - Maurizio V
FA  - Giuseppe, Caminiti
FA  - Chiara, Fossati
FA  - Giuseppe, Rosano
FA  - Maurizio, Volterrani
IN  - Giuseppe,Caminiti. S. Raffaele Pisana, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy. Electronic address: giuseppe.caminiti@sanraffaele.it.
IN  - Chiara,Fossati. S. Raffaele Pisana, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
IN  - Giuseppe,Rosano. S. Raffaele Pisana, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
IN  - Maurizio,Volterrani. S. Raffaele Pisana, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
TI  - Addition of ivabradine to betablockers in patients with atrial fibrillation: Effects on heart rate and exercise tolerance.
SO  - International Journal of Cardiology. 202:73-4, 2016 Jan 1.
AS  - Int J Cardiol. 202:73-4, 2016 Jan 1.
NJ  - International journal of cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - gqw, 8200291
SB  - Index Medicus
CP  - Netherlands
ES  - 1874-1754
IL  - 0167-5273
DI  - S0167-5273(15)30435-6
DO  - http://dx.doi.org/10.1016/j.ijcard.2015.08.207
PT  - Letter
LG  - English
EP  - 20150831
DP  - 2016 Jan 1
DC  - 20151123
YR  - 2016
UP  - 20160226
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26386926

<1037. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25469735
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - D'Ascenzi F
AU  - Cameli M
AU  - Ciccone MM
AU  - Maiello M
AU  - Modesti PA
AU  - Mondillo S
AU  - Muiesan ML
AU  - Scicchitano P
AU  - Novo S
AU  - Palmiero P
AU  - Saba PS
AU  - Pedrinelli R
AU  - Gruppo di Studio Ipertensione, Prevenzione e Riabilitazione, Societa Italiana di Cardiologia
FA  - D'Ascenzi, Flavio
FA  - Cameli, Matteo
FA  - Ciccone, Marco M
FA  - Maiello, Maria
FA  - Modesti, Pietro A
FA  - Mondillo, Sergio
FA  - Muiesan, Maria L
FA  - Scicchitano, Pietro
FA  - Novo, Salvatore
FA  - Palmiero, Pasquale
FA  - Saba, Pier S
FA  - Pedrinelli, Roberto
FA  - Gruppo di Studio Ipertensione, Prevenzione e Riabilitazione, Societa Italiana di Cardiologia
IN  - D'Ascenzi,Flavio. aCardiologia Universitaria, Universita degli Studi di Siena, Siena bDipartimento di Emergenza e Trapianto Organi, Universita degli Studi di Bari, Bari cAzienda Sanitaria Locale di Brindisi, Brindisi dDipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Firenze, Firenze eDipartimento di Scienze Cliniche e Sperimentali, Universita degli Studi di Brescia, Brescia fDipartimentodi Medicina Interna e Malattie Cardiovascolari, Universita degli Studi di Palermo, Palermo gDipartimento di Medicina Clinica e Sperimentale, Universita degli Studidi Sassari, Sassari hDipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Universita di Pisa, Pisa, Italy.
TI  - The controversial relationship between exercise and atrial fibrillation: clinical studies and pathophysiological mechanisms.
SO  - Journal of Cardiovascular Medicine. 16(12):802-10, 2015 Dec.
AS  - J Cardiovasc Med (Hagerstown). 16(12):802-10, 2015 Dec.
NJ  - Journal of cardiovascular medicine (Hagerstown, Md.)
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - 101259752
SB  - Index Medicus
CP  - United States
AB  - Atrial fibrillation is the most common clinically significant arrhythmia observed both in the general population and in competitive athletes. The most important risk factors are all preventable by regular physical activity. However, although the benefits of moderate physical activity in controlling cardiovascular risk factors and decreasing the risk of atrial fibrillation have been extensively proved, concerns have arisen about the potential negative effects of vigorous exercise, particularly in endurance athletes. Furthermore, in a subset of patients with atrial fibrillation younger than 60 years, routine evaluation does not reveal any cardiovascular disease or any other known causal factor. This condition is called 'lone atrial fibrillation', and the potential mechanisms underlying this condition are speculative and remain to be clarified. Atrial ectopy, increased vagal tone, changes in electrolytes, left atrial dilatation, and fibrosis have been proposed among others as potential mechanisms. However, no convincing data still exist. Particularly, the increase in left atrial size represents in athletes a physiological adaptation to exercise conditioning and the presence of biatrial fibrosis has not been demonstrated in humans. Thus, contrary to patients with cardiovascular disorders, the atrial substrate seems to play a secondary role in healthy athletes. This review article analyzes the controversial relationship between atrial fibrillation and physical activity, with a particular attention on the pathophysiological mechanisms that could be responsible for atrial fibrillation in the athletic population.
ES  - 1558-2035
IL  - 1558-2027
DO  - http://dx.doi.org/10.2459/JCM.0000000000000211
PT  - Journal Article
LG  - English
DP  - 2015 Dec
DC  - 20151029
YR  - 2015
UP  - 20160128
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25469735

<1038. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26142297
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Hajhosseiny R
AU  - Matthews GK
AU  - Lip GY
FA  - Hajhosseiny, Reza
FA  - Matthews, Gareth K
FA  - Lip, Gregory Y H
IN  - Hajhosseiny,Reza. British Heart Foundation Centre of Cardiovascular Excellence, St. Thomas' Hospital, London, United Kingdom. Electronic address: reza.hajhosseiny@kcl.ac.uk.
IN  - Matthews,Gareth K. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
IN  - Lip,Gregory Y H. University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom,; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
TI  - Metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic.
SO  - Heart Rhythm. 12(11):2332-43, 2015 Nov.
AS  - Heart Rhythm. 12(11):2332-43, 2015 Nov.
NJ  - Heart rhythm : the official journal of the Heart Rhythm Society
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101200317
SB  - Index Medicus
CP  - United States
KW  - Anticoagulation;  Atrial fibrillation;  Metabolic syndrome;  NOACs;  Stroke;  Warfarin
AB  - The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle. These essentially modifiable risk factors are becoming more prevalent with the widespread adoption of so-called Western lifestyles. This review examines the physiology underlying the link between the metabolic syndrome and AF. Next, it highlights the importance of addressing lifestyle-related risk factors to mitigate the trend toward increasing AF prevalence. It then goes on to discuss the importance of stroke prevention therapy in patients with established AF, focusing on the relative merits of various available options for anticoagulation. Given the recent availability of comprehensive data on the 4 currently available non-vitamin K antagonist oral anticoagulant drugs, this review concludes by discussing the relative merits of specific agents in individual patient groups. Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
ES  - 1556-3871
IL  - 1547-5271
DI  - S1547-5271(15)00812-7
DO  - http://dx.doi.org/10.1016/j.hrthm.2015.06.038
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20150630
DP  - 2015 Nov
DC  - 20151027
YR  - 2015
UP  - 20160122
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26142297

<1039. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26520692
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Data-Review
AU  - Ongun S
AU  - Bozkurt O
AU  - Demir O
AU  - Cimen S
AU  - Aslan G
FA  - Ongun, Sakir
FA  - Bozkurt, Ozan
FA  - Demir, Omer
FA  - Cimen, Sertac
FA  - Aslan, Guven
IN  - Ongun,Sakir. Department of Urology, SB Siverek State Hospital, Sanliurfa, Turkey. Electronic address: sakirongun@hotmail.com.
IN  - Bozkurt,Ozan. Department of Urology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
IN  - Demir,Omer. Department of Urology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
IN  - Cimen,Sertac. Department of Urology, SB Ankara Diskapi Training Hospital, Ankara, Turkey.
IN  - Aslan,Guven. Department of Urology, SB Ankara Diskapi Training Hospital, Ankara, Turkey.
TI  - Midterm renal functions following acute renal infarction.
SO  - Kaohsiung Journal of Medical Sciences. 31(10):529-33, 2015 Oct.
AS  - Kaohsiung J Med Sci. 31(10):529-33, 2015 Oct.
NJ  - The Kaohsiung journal of medical sciences
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 100960562, ds3
SB  - Index Medicus
CP  - China (Republic : 1949- )
KW  - Atrial fibrillation;  Lactate dehydrogenase;  Renal infarction;  eGFR
AB  - The aim of this study was to explore clinical features of renal infarction (RI) that may have a role in diagnosis and treatment in our patient cohort and provide data on midterm renal functions. Medical records of patients with diagnosis of acute RI, established by contrast enhanced computed tomography (CT) and at least 1 year follow-up data, who were hospitalized in our clinic between 1998 and 2012 were retrospectively reviewed; including descriptive data, clinical signs and symptoms, etiologic factors, laboratory findings, and prescribed treatments. Patients with solitary infarct were treated with acetylsalicylic acid (ASA) only, whereas patients with atrial fibrillation (AF) or multiple or global infarct were treated with anticoagulants. Estimated Glomerular Filtration Rate (eGFR) referring to renal functions was determined by the Modification of Diet in Renal Disease (MDRD) formula. Twenty-seven renal units of 23 patients with acute RI were identified. The mean age was 59.7 +/- 15.7 years. Fourteen patients (60.8%) with RI had atrial fibrillation (AF) as an etiologic factor of which four had concomitant mesenteric ischemia at diagnosis. At presentation, 20 patients (86.9%) had elevated serum lactate dehydrogenase (LDH), 18 patients (78.2%) had leukocytosis, and 16 patients (69.5%) had microscopic hematuria. Two patients with concomitant mesenteric ischemia and AF passed away during follow up. Mean eGFR was 70.8 +/- 23.2 mL/min/1.73 m(2) at admission and increased to 82.3 +/- 23.4 mL/min/1.73 m(2) at 1 year follow up. RI should be considered in patients with persistent flank or abdominal pain, particularly if they are at high risk of thromboembolism. Antiplatelet and/or anticoagulant drugs are both effective treatment options according to the amplitude of the infarct for preserving kidney functions. Copyright © 2015. Published by Elsevier Taiwan.
IS  - 1607-551X
IL  - 1607-551X
DI  - S1607-551X(15)00169-2
DO  - http://dx.doi.org/10.1016/j.kjms.2015.07.005
PT  - Journal Article
LG  - English
EP  - 20150824
DP  - 2015 Oct
DC  - 20151102
YR  - 2015
UP  - 20151217
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26520692

<1040. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26117593
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Lin SW
AU  - Weng WC
AU  - Huang YH
AU  - Su FC
AU  - Peng TI
AU  - Chien YY
AU  - Wu CL
AU  - Lee KY
AU  - Yu YJ
AU  - Zhu JX
AU  - Huang WY
FA  - Lin, Shun-Wen
FA  - Weng, Wei-Chieh
FA  - Huang, Yu-Hua
FA  - Su, Feng-Chieh
FA  - Peng, Tsung-I
FA  - Chien, Yu-Yi
FA  - Wu, Chia-Lun
FA  - Lee, Kuang-Yung
FA  - Yu, Yi-Jing
FA  - Zhu, Jun-Xue
FA  - Huang, Wen-Yi
IN  - Lin,Shun-Wen. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Weng,Wei-Chieh. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Huang,Yu-Hua. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Su,Feng-Chieh. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Peng,Tsung-I. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Chien,Yu-Yi. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Wu,Chia-Lun. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Lee,Kuang-Yung. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Yu,Yi-Jing. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Zhu,Jun-Xue. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan.
IN  - Huang,Wen-Yi. Department of Neurology, Chang-Gung Memorial Hospital, Keelung Branch, No. 222, Mai-Jin Road, Keelung Zip. 204, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan Zip. 333, Taiwan. Electronic address: wenyihuang2003@yahoo.com.tw.
TI  - Association between renal dysfunction and 3-year mortality in patients with acute first-ever ischemic stroke.
SO  - Clinical Neurology & Neurosurgery. 137:15-21, 2015 Oct.
AS  - Clin Neurol Neurosurg. 137:15-21, 2015 Oct.
NJ  - Clinical neurology and neurosurgery
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - df4, 7502039
SB  - Index Medicus
CP  - Netherlands
KW  - Chronic kidney disease;  First-ever ischemic stroke;  Mortality;  Recurrent stroke;  Renal dysfunction;  Stroke outcome
AB  - OBJECTIVE: The influence of renal dysfunction on the clinical presentation and outcomes of patients with acute ischemic stroke is still controversial. We investigate the influence of renal dysfunction on the outcomes of patients with acute first-ever ischemic stroke.
AB  - METHODS: Nine-hundred thirty-four patients with acute first-ever ischemic stroke were enrolled and followed for 3 years. Renal function was assessed using the equation of the Modification Diet for Renal Disease for estimated glomerular filtration rate (eGFR). Serum creatinine levels were obtained within 3 days of acute stroke onset. Reduced eGFR was defined as eGFR<60ml/min/1.73m(2). Clinical presentation, risk factors for stroke, laboratory data, co-morbidities, and outcomes were recorded.
AB  - RESULTS: Total 264 patients (28.3%) had a reduced eGFR. The prevalence of older age, hypertension, and atrial fibrillation was significantly higher in patients with a reduced eGFR. Total anterior circulation syndrome occurred more frequently among patients with a reduced eGFR (P=0.010). Multivariate Cox regression revealed that a reduced eGFR is a significant predictor of 3-year mortality (HR=1.67, 95% CI=1.06-2.62, P=0.026).
AB  - CONCLUSION: Reduced eGFR during the acute stroke stage is associated with increased risk of 3-year mortality. Furthermore, risk of acute complications and poor functional outcomes following discharge was significantly higher in patients with a reduced eGFR.Copyright © 2015 Elsevier B.V. All rights reserved.
ES  - 1872-6968
IL  - 0303-8467
DI  - S0303-8467(15)00231-0
DO  - http://dx.doi.org/10.1016/j.clineuro.2015.06.008
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20150617
DP  - 2015 Oct
DC  - 20150910
YR  - 2015
UP  - 20151217
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26117593

<1041. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25935226
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Danon A
AU  - Shurrab M
AU  - Nair KM
AU  - Latcu DG
AU  - Arruda MS
AU  - Chen X
AU  - Szili-Torok T
AU  - Rossvol O
AU  - Wissner EE
AU  - Lashevsky I
AU  - Crystal E
FA  - Danon, Asaf
FA  - Shurrab, Mohammed
FA  - Nair, Krishnakumar Mohanan
FA  - Latcu, Decebal Gabriel
FA  - Arruda, Mauricio S
FA  - Chen, Xu
FA  - Szili-Torok, Tamas
FA  - Rossvol, Ole
FA  - Wissner, Eric E
FA  - Lashevsky, Ilan
FA  - Crystal, Eugene
IN  - Danon,Asaf. Arrhythmia service, Schulich Heart Centre, Department of Cardiology, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Canada, asdanon@gmail.com.
TI  - Atrial fibrillation ablation using remote magnetic navigation and the risk of atrial-esophageal fistula: international multicenter experience.
SO  - Journal of Interventional Cardiac Electrophysiology. 43(2):169-74, 2015 Aug.
AS  - J Interv Card Electrophysiol. 43(2):169-74, 2015 Aug.
NJ  - Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - c8k, 9708966
SB  - Index Medicus
CP  - Netherlands
AB  - PURPOSE: Remote magnetic navigation (RMN) has been used in various electrophysiological procedures, including atrial fibrillation (AF) ablation. Atrial-esophageal fistula (AEF) is one of most disastrous complications of AF ablation. We aimed to evaluate the incidence of AEF during AF ablation using RMN in comparison to manual ablation.
AB  - METHODS: We conducted the first international survey among RMN operators for assessment of the prevalence of AEF and procedural parameters affecting the risk. Data from parallel survey of AEF among Canadian interventional electrophysiologists (CIE) using only manual catheters served as control.
AB  - RESULTS: Fifteen RMN operators (who performed 3637 procedures) and 25 manual CIE operators (7016 procedures) responded to the survey. RMN operators were more experienced than CIE operators (16.3+/-8.3 vs. 9.2+/-5.4 practice years in electrophysiology, p=0.007). The maximal energy output in the posterior wall was higher in the operator using RMN (33+/-5 vs. 28.6+/-4.9 W; p=0.02). Other parameters including use of preprocedural images, irrigated catheter, pump flow rate, esophageal temperature monitoring, intracardiac echocardiography (ICE), and general anesthesia were similar. CIE operators administered proton-pump inhibitors postoperatively significantly more than RMN operators (76 vs. 35%, p=0.01). AEF was reported in 5 of the 7016 patients in the control group (0.07%) but in none of the RMN group (p=0.11).
AB  - CONCLUSIONS: AEF is a rare complication and its evaluation necessitates large-scale studies. Although no AEF case with RMN was reported in this large study or previously on the literature, the rarity of this complication prevents firm conclusion about the risk.
ES  - 1572-8595
IL  - 1383-875X
DO  - http://dx.doi.org/10.1007/s10840-015-0003-7
PT  - Journal Article
LG  - English
EP  - 20150503
DP  - 2015 Aug
DC  - 20150630
YR  - 2015
UP  - 20151217
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25935226

<1042. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25457087
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Manzano-Fernandez S
AU  - Andreu-Cayuelas JM
AU  - Marin F
AU  - Orenes-Pinero E
AU  - Gallego P
AU  - Valdes M
AU  - Vicente V
AU  - Lip GY
AU  - Roldan V
FA  - Manzano-Fernandez, Sergio
FA  - Andreu-Cayuelas, Jose M
FA  - Marin, Francisco
FA  - Orenes-Pinero, Esteban
FA  - Gallego, Pilar
FA  - Valdes, Mariano
FA  - Vicente, Vicente
FA  - Lip, Gregory Y H
FA  - Roldan, Vanessa
IN  - Manzano-Fernandez,Sergio. Servicio de Cardiologia, Hospital Clinico Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigacion Biosanitaria, Murcia, Spain.
IN  - Andreu-Cayuelas,Jose M. Servicio de Cardiologia, Hospital Clinico Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigacion Biosanitaria, Murcia, Spain.
IN  - Marin,Francisco. Servicio de Cardiologia, Hospital Clinico Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigacion Biosanitaria, Murcia, Spain.
IN  - Orenes-Pinero,Esteban. Servicio de Cardiologia, Hospital Clinico Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigacion Biosanitaria, Murcia, Spain.
IN  - Gallego,Pilar. Servicio de Hematologia, Hospital Rafael Mendez, Lorca, Murcia, Spain.
IN  - Valdes,Mariano. Servicio de Cardiologia, Hospital Clinico Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigacion Biosanitaria, Murcia, Spain.
IN  - Vicente,Vicente. Unidad de Hematologia y Oncologia Medica, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain.
IN  - Lip,Gregory Y H. Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom. Electronic address: g.y.h.lip@bham.ac.uk.
IN  - Roldan,Vanessa. Unidad de Hematologia y Oncologia Medica, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain.
TI  - Comparison of estimated glomerular filtration rate equations for dosing new oral anticoagulants in patients with atrial fibrillation.
SO  - Revista Espanola de Cardiologia. 68(6):497-504, 2015 Jun.
AS  - Rev Esp Cardiol (Engl). 68(6):497-504, 2015 Jun.
NJ  - Revista espanola de cardiologia (English ed.)
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101587954
SB  - Index Medicus
CP  - Spain
KW  - Anticoagulant;  Anticoagulante;  Atrial fibrillation;  Dosing;  Fibrilacion auricular;  Funcion renal;  Posologia;  Renal function
AB  - INTRODUCTION AND OBJECTIVES: New oral anticoagulants require dosing adjustment according to renal function. We aimed to determine discordance in hypothetical recommended dosing of these drugs using different estimated glomerular filtration rate equations in patients with atrial fibrillation.
AB  - METHODS: Cross-sectional analysis of 910 patients with atrial fibrillation and an indication for oral anticoagulation. The glomerular filtration rate was estimated using the Cockcroft-Gault, Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration equations. For dabigatran, rivaroxaban, and apixaban we identified dose discordance when there was disagreement in the recommended dose based on different equations.
AB  - RESULTS: Among the overall population, relative to Cockcroft-Gault, discordance in dabigatran dosage was 11.4% for Modification of Diet in Renal Disease and 10% for Chronic Kidney Disease Epidemiology Collaboration, discordance in rivaroxaban dosage was 10% for Modification of Diet in Renal Disease and 8.5% for the Chronic Kidney Disease Epidemiology Collaboration. The lowest discordance was observed for apixaban: 1.4% for Modification of Diet in Renal Disease and 1.5% for the Chronic Kidney Disease Epidemiology Collaboration. In patients with Cockcroft-Gault<60mL/min or elderly patients, discordances in dabigatran and rivaroxaban dosages were higher, ranging from 13.2% to 30.4%. Discordance in apixaban dosage remained<5% in these patients.
AB  - CONCLUSIONS: Discordance in new oral anticoagulation dosages using different equations is frequent, especially among elderly patients with renal impairment. This discordance was higher in dabigatran and rivaroxaban dosages than in apixaban dosages. Further studies are needed to clarify the clinical importance of these discordances and the optimal anticoagulant dosages depending on the use of different equations to estimate renal function.Copyright © 2014 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
ES  - 1885-5857
IL  - 1885-5857
DI  - S1885-5857(14)00397-1
DO  - http://dx.doi.org/10.1016/j.rec.2014.06.026
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
LG  - English
EP  - 20141120
DP  - 2015 Jun
DC  - 20150526
YR  - 2015
UP  - 20151217
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25457087

<1043. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25369511
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - In-Process
AU  - Niewada M
AU  - Czlonkowska A
FA  - Niewada, Maciej
FA  - Czlonkowska, Anna
TI  - Prevention of ischemic stroke in clinical practice: a role of internists and general practitioners.
SO  - Polskie Archiwum Medycyny Wewnetrznej. 124(10):540-8, 2014.
AS  - Pol Arch Med Wewn. 124(10):540-8, 2014.
NJ  - Polskie Archiwum Medycyny Wewnetrznej
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - pav, 0401225
SB  - Index Medicus
CP  - Poland
AB  - Stroke constitutes a substantial clinical and socio-economic burden. It is currently the third cause of death worldwide and results in mortality or disability in every third patient at the end of the first year following an acute cerebrovascular event. Although in-hospital mortality rates in stroke patients have decreased, prevention and cardiovascular risk control remain critical for improving the prognosis and reducing stroke burden worldwide. The definitions of stroke and transient ischemic attack (TIA) have been recently modified following the findings from neuroimaging and thrombolysis research. Both stroke and TIA are recurrent and preventable disorders. Both patients with stroke and those with TIA require prompt clinical workup, risk assessment, and appropriate management because the risk of recurrence, stroke, and coronary events is significant. The 5 most common cardiovascular risk factors (high blood pressure, smoking, abdominal obesity, diet, and lack of physical activity) are responsible for 80% of the cases. Stroke prevention involves lifestyle modification and specific treatment. Secondary prevention of ischemic stroke involves early treatment (antiplatelets and carotid interventions) and long-term management including lifestyle changes, antihypertensive therapy, antiplatelets, antithrombotic drugs in patients with atrial fibrillation, and the use of statins and other lipid-lowering drugs. Stroke patients are at risk of depression, dementia, epilepsy, and other complications that also require targeted treatment.
ES  - 1897-9483
IL  - 0032-3772
PT  - Journal Article
LG  - English
DP  - 2014
DC  - 20141105
YR  - 2014
UP  - 20151217
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25369511

<1044. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27472911
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Monrad M
AU  - Sajadieh A
AU  - Christensen JS
AU  - Ketzel M
AU  - Raaschou-Nielsen O
AU  - Tjonneland A
AU  - Overvad K
AU  - Loft S
AU  - Sorensen M
FA  - Monrad, Maria
FA  - Sajadieh, Ahmad
FA  - Christensen, Jeppe Schultz
FA  - Ketzel, Matthias
FA  - Raaschou-Nielsen, Ole
FA  - Tjonneland, Anne
FA  - Overvad, Kim
FA  - Loft, Steffen
FA  - Sorensen, Mette
IN  - Monrad,Maria. Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
IN  - Sajadieh,Ahmad. Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Bispebjerg Denmark.
IN  - Christensen,Jeppe Schultz. Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
IN  - Ketzel,Matthias. Department of Environmental Science, Aarhus University, Roskilde, Denmark.
IN  - Raaschou-Nielsen,Ole. Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
IN  - Raaschou-Nielsen,Ole. Department of Environmental Science, Aarhus University, Roskilde, Denmark.
IN  - Tjonneland,Anne. Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
IN  - Overvad,Kim. Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
IN  - Loft,Steffen. Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
IN  - Sorensen,Mette. Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
TI  - Long-Term Exposure to Traffic-Related Air Pollution and Risk of Incident Atrial Fibrillation: A Cohort Study.
SO  - Environmental Health Perspectives. , 2016 Jul 29.
AS  - Environ Health Perspect. , 2016 Jul 29.
NJ  - Environmental health perspectives
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - ei0, 0330411
AB  - BACKGROUND: Atrial fibrillation is the most common sustained arrhythmia and associated with cardiovascular morbidity and mortality. The few studies conducted on short-term effects of air pollution on episodes of atrial fibrillation indicates a positive association, though not consistently.
AB  - OBJECTIVES: The aim of this study was to evaluate the long-term impact of traffic-related air pollution on incidence of atrial fibrillation in the general population.
AB  - METHODS: In the Danish Diet, Cancer, and Health cohort of 57,053 people aged 50-64 years at enrolment in 1993-1997, we identified 2,700 cases of first-ever hospital admission for atrial fibrillation from enrolment to end of follow-up in 2011. For all cohort members, exposure to traffic-related air pollution assessed as nitrogen dioxide (NO2) and nitrogen oxides (NOx) was estimated at all present and historical residential addresses from 1984 to 2011 using a validated dispersion model. We used Cox proportional hazard model to estimate associations between long-term residential exposure to NO2 and NOx and risk of atrial fibrillation, after adjustment for lifestyle and socioeconomic position.
AB  - RESULTS: A 10 micro g/m(3) higher 10-years' time-weighted mean exposure to NO2 preceding diagnosis was associated with an 8% higher risk of atrial fibrillation (incidence rate ratio: 1.08; 95% confidence interval: 1.01-1.14) in adjusted analysis. Though weaker, similar results were obtained for long-term residential exposure to NOx. We found no clear tendencies regarding effect modification of the association between NO2 and atrial fibrillation by sex, smoking, hypertension or myocardial infarction.
AB  - CONCLUSION: We found long-term residential traffic-related air pollution to be associated with higher risk of atrial fibrillation. Accordingly, the present findings lend further support to the demand for abatement of air pollution.
ES  - 1552-9924
IL  - 0091-6765
DO  - http://dx.doi.org/10.1289/EHP392
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016729
DP  - 2016 Jul 29
DC  - 20160729
YR  - 2016
RD  - 20160729
UP  - 20160801
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27472911

<1045. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27438598
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Pandya EY
AU  - Bajorek B
FA  - Pandya, Ekta Y
FA  - Bajorek, Beata
IN  - Pandya,Ekta Y. Graduate School of Health, University of Technology Sydney, Building 7, 67 Thomas Street, Ultimo, NSW, 2007, Australia. Ekta.Y.Pandya@student.uts.edu.au.
IN  - Bajorek,Beata. Graduate School of Health, University of Technology Sydney, Building 7, 67 Thomas Street, Ultimo, NSW, 2007, Australia.
IN  - Bajorek,Beata. Pharmacy Department, Royal North Shore Hospital, St Leonards, NSW, Australia.
TI  - Factors Affecting Patients' Perception On, and Adherence To, Anticoagulant Therapy: Anticipating the Role of Direct Oral Anticoagulants.
SO  - The Patient: Patient-Centered Outcomes Research. , 2016 Jul 20.
AS  - Patient. , 2016 Jul 20.
NJ  - The patient
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101309314
AB  - The role of the direct oral anticoagulants (DOACs) in practice has been given extensive consideration recently, albeit largely from the clinician's perspective. However, the effectiveness and safety of using anticoagulants is highly dependent on the patient's ability to manage and take these complex, high-risk medicines. This structured narrative review explores the published literature to identify the factors underpinning patients' non-adherence to anticoagulants in atrial fibrillation (AF), and subsequently contemplates to what extent the DOACs might overcome the known challenges with traditional warfarin therapy. This review comprised a two-tier search of various databases and search platforms (CINAHL, Cochrane, Current Contents Connect, EMBASE, MEDLINE Ovid, EBSCO, PubMed, Google, Google Scholar) to yield 47 articles reporting patients perspectives on, and patients adherence to, anticoagulant therapy. The findings from the literature were synthesised under five interacting dimensions of adherence: therapy-related factors, patient-related factors, condition-related factors, social-economic factors and health system factors. Factors negatively affecting patients' day-to-day lives (especially regular therapeutic drug monitoring, dose adjustments, dietary considerations) predominantly underpin a patient's reluctance to take warfarin therapy, leading to non-adherence. Other patient-related factors underpinning non-adherence include patients' perceptions and knowledge about the purpose of anticoagulation; understanding of the risks and benefits of therapy; socioeconomic status; and expectations of care from health professionals. In considering these findings, it is apparent that the DOACs may overcome some of the barriers to traditional warfarin therapy at least to an extent, particularly the need for regular monitoring, frequent dose adjustment and dietary considerations. However, their high cost, twice-daily dosing and gastrointestinal adverse effects may present additional challenges for patients and health systems. The review highlights the need to explicitly incorporate patients' perspectives in decision-making processes for anticoagulant selection, to obtain optimum adherence and treatment outcomes. Further studies should explore resources that can better engage patients in decision making around the selection of anticoagulant therapy.
ES  - 1178-1661
IL  - 1178-1653
DO  - http://dx.doi.org/10.1007/s40271-016-0180-1
PT  - REVIEW
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016720
DP  - 2016 Jul 20
DC  - 20160720
YR  - 2016
RD  - 20160720
UP  - 20160722
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27438598

<1046. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27406157
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - McDonald C
AU  - Fraser J
AU  - Shekar K
AU  - Clarke A
AU  - Coombes J
AU  - Barnett A
AU  - Pearse B
AU  - Fung L
FA  - McDonald, C
FA  - Fraser, J
FA  - Shekar, K
FA  - Clarke, A
FA  - Coombes, J
FA  - Barnett, A
FA  - Pearse, B
FA  - Fung, L
IN  - McDonald,C. Anaesthesia and Perfusion Services, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - McDonald,C. Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
IN  - Fraser,J. Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
IN  - Fraser,J. Adult Intensive Care Services, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - Shekar,K. Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
IN  - Shekar,K. Adult Intensive Care Services, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - Clarke,A. Department of Cardiac Surgery, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - Coombes,J. School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, Queensland, Australia.
IN  - Barnett,A. Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
IN  - Barnett,A. Queensland University of Technology, Kelvin Grove, Queensland, Australia.
IN  - Pearse,B. Anaesthesia and Perfusion Services, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - Pearse,B. Adult Intensive Care Services, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - Pearse,B. Department of Cardiac Surgery, The Prince Charles Hospital, Chermside, Queensland, Australia.
IN  - Fung,L. Critical Care Research Group, The Prince Charles Hospital, The University of Queensland, Brisbane, Queensland, Australia.
IN  - Fung,L. School of Health and Sports Science, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
TI  - Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery.
SO  - European Journal of Clinical Nutrition. , 2016 Jul 13.
AS  - Eur J Clin Nutr. , 2016 Jul 13.
NJ  - European journal of clinical nutrition
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - ejc, 8804070
AB  - BACKGROUND/OBJECTIVES: Post-operative atrial fibrillation (POAF) is a frequent complication of cardiac surgery. Oxidative stress and reduced antioxidant function have major roles in its development. Selenium is a key to normal antioxidant function, and levels are often low before cardiac surgery. This study investigated whether low preoperative selenium levels were associated with POAF in cardiac surgical patients.
AB  - SUBJECTS/METHODS: Using the Society of Thoracic Surgeons (STS) Mortality risk score, 50 patients having primary coronary artery bypass grafts (CABG) surgery were divided into two groups: (i) low-risk group (STS 0.5%; n=26) and (ii) intermediate-risk group (STS 2.0%; n=24). Plasma levels of selenium, glutathione peroxidase (GPx) and malondialdehyde (MDA) were measured in all patients at anaesthetic induction, after aortic cross-clamp removal, 3h post cardiopulmonary bypass and on post-operative days 1 and 5. Multiple logistic regression was used to assess whether selenium levels were associated with POAF development.
AB  - RESULTS: Seventeen patients developed POAF (14 patients in the intermediate-risk group and 3 patients in the low-risk group). Preoperative selenium was lower in patients who developed POAF compared with those with normal sinus rhythm (0.73+/-0.16 vs 0.89+/-0.13mumol/l, P=0.005), and this was independently associated with POAF (PR 0.32; 95% confidence credible interval (95%cI) 0.06-0.85, P=0.016). Regardless of POAF, preoperative selenium was lower in the intermediate-risk patients than in the low-risk patients (0.77+/-0.15 vs 0.89+/-0.14mumol/l; P=0.004).
AB  - CONCLUSIONS: Intermediate-risk patients with low preoperative selenium levels may be at a greater risk of developing POAF following CABG. This raises the question of whether selenium supplementation in select cardiac surgical patients may reduce their POAF risk.European Journal of Clinical Nutrition advance online publication, 13 July 2016; doi:10.1038/ejcn.2016.125.
ES  - 1476-5640
IL  - 0954-3007
DO  - http://dx.doi.org/10.1038/ejcn.2016.125
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016713
DP  - 2016 Jul 13
DC  - 20160713
YR  - 2016
RD  - 20160713
UP  - 20160715
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27406157

<1047. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27390965
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Ageno W
AU  - Eikelboom J
AU  - Lip GY
FA  - Ageno, Walter
FA  - Eikelboom, John
FA  - Lip, Gregory Y H
IN  - Ageno,Walter. Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
IN  - Eikelboom,John. McMaster University, Hamilton, Canada.
IN  - Lip,Gregory Y H. University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address: g.y.h.lip@bham.ac.uk.
TI  - Dabigatran in clinical practice: Contemporary overview of the evidence.
SO  - International Journal of Cardiology. 220:417-428, 2016 Jun 23.
AS  - Int J Cardiol. 220:417-428, 2016 Jun 23.
NJ  - International journal of cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - gqw, 8200291
KW  - Atrial fibrillation;  Dabigatran;  Systemic embolism;  Venous thromboembolism
AB  - Oral anticoagulation is the cornerstone of stroke prevention in non-valvular atrial fibrillation (AF) and management of venous thromboembolism (VTE), resulting in a reduction in thrombotic complications and mortality. Benefit of vitamin K antagonists (VKAs) in such patients has been unambiguously confirmed, but VKA use is complicated by need for regular monitoring of the international normalized ratio and multiple drug and food interactions. Dabigatran is an oral direct thrombin inhibitor that can be used with fixed doses, without the need for routine anticoagulation laboratory monitoring and the advantage of few drug or diet interactions. Dabigatran is effective for stroke and systemic thromboembolism in AF and for the prophylaxis and treatment of VTE. The drug has a good safety profile and consistently shows a reduction in intracranial hemorrhage risk compared to warfarin. A specific reversal agent for dabigatran has been approved by FDA and EU. This review provides a summary of publications assessing clinical utility of dabigatran for different indications.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
ES  - 1874-1754
IL  - 0167-5273
DO  - http://dx.doi.org/10.1016/j.ijcard.2016.06.078
PT  - REVIEW
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016623
DP  - 2016 Jun 23
DC  - 20160708
YR  - 2016
RD  - 20160708
UP  - 20160711
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27390965

<1048. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27245609
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Mohanty S
AU  - Mohanty P
AU  - Tamaki M
AU  - Natale V
AU  - Gianni C
AU  - Trivedi C
AU  - Gokoglan Y
AU  - DI Biase L
AU  - Natale A
FA  - Mohanty, Sanghamitra
FA  - Mohanty, Prasant
FA  - Tamaki, Megumi
FA  - Natale, Veronica
FA  - Gianni, Carola
FA  - Trivedi, Chintan
FA  - Gokoglan, Yalcin
FA  - DI Biase, Luigi
FA  - Natale, Andrea
IN  - Mohanty,Sanghamitra. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - Mohanty,Prasant. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - Tamaki,Megumi. Texas Cardiac Arrhythmia Research Foundation, Austin, Texas.
IN  - Natale,Veronica. Department of Natural Science, University of Texas, Austin, Texas.
IN  - Gianni,Carola. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - Gianni,Carola. University of Milan, Milan, Italy.
IN  - Trivedi,Chintan. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - Gokoglan,Yalcin. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - Gokoglan,Yalcin. Department of Cardiology, Gulhane Military Academy of Medicine, Ankara, Turkey.
IN  - DI Biase,Luigi. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - DI Biase,Luigi. Albert Einstein College of Medicine, Montefiore Hospital, Bronx, New York.
IN  - Natale,Andrea. Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
IN  - Natale,Andrea. California Pacific Medical Center, San Francisco, California, USA.
IN  - Natale,Andrea. Interventional Electrophysiology, Scripps Clinic, San Diego, California, USA.
IN  - Natale,Andrea. Department of Internal Medicine, Dell Medical School, Austin, Texas, USA.
IN  - Natale,Andrea. Division of Cardiology, Stanford University, Palo Alto, California, USA.
TI  - Differential Association of Exercise Intensity With Risk of Atrial Fibrillation in Men and Women: Evidence from a Meta-Analysis.
SO  - Journal of Cardiovascular Electrophysiology. , 2016 Jun 1.
AS  - J Cardiovasc Electrophysiol. , 2016 Jun 1.
NJ  - Journal of cardiovascular electrophysiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - by4, 9010756
KW  - atrial fibrillation;  exercise intensity;  gender;  physical activity;  sedentary
AB  - BACKGROUND: Despite widespread interest and extensive research, the association between different levels of physical activity (PA) and risk of atrial fibrillation (AF) is still not clearly defined. Therefore, we systematically evaluated and summarized the evidences regarding association of different intensity of PA with the risk of AF in this meta-analysis.
AB  - METHODS AND RESULTS: An extensive literature search was performed on databases for studies showing association of exercise with AF risk. Twenty-two studies were identified that included 656,750 subjects. Meta-analytic estimates were derived using random-effects models and pooled odds ratio estimates were obtained. Potential sources of heterogeneity were examined in sensitivity analyses, and publication biases were estimated. Pooled analysis of 7 studies with 93,995 participants reported high risk of incident AF with sedentary lifestyle (pooled OR 2.47 [95% CI 1.25-3.7], P = 0.005). In 3 trials, 149,048 women involved in moderate PA were 8.6% less likely to develop AF compared to women with sedentary life (OR 0.91 [95% CI 0.78-0.97], P = 0.002). Women performing intense exercise were found to have 28% lower risk of AF (OR 0.72 [95% CI 0.57-0.88], P < 0.001). The overall pooled estimate indicated a protective impact of moderate PA in men (pooled OR 0.8133 [95% CI 0.26-1.004], P = 0.06) whereas vigorous PA was associated with a significantly increased AF risk (pooled OR 3.30 [1.97-4.63], P = 0.0002).
AB  - CONCLUSION: Sedentary lifestyle significantly increases and moderate amount of physical activity reduces the risk of AF in both men and women. However, intense exercise has a gender-specific association with AF risk.Copyright © 2016 Wiley Periodicals, Inc.
ES  - 1540-8167
IL  - 1045-3873
DO  - http://dx.doi.org/10.1111/jce.13023
PT  - JOURNAL ARTICLE
LG  - English
EP  - 201661
DP  - 2016 Jun 1
DC  - 20160707
YR  - 2016
RD  - 20160707
UP  - 20160708
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27245609

<1049. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27322862
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Tutar E
AU  - Ciftci O
AU  - Fitoz S
AU  - Kendirli T
AU  - Odek C
AU  - Ucar T
AU  - Kansu A
FA  - Tutar, Ercan
FA  - Ciftci, Omer
FA  - Fitoz, Suat
FA  - Kendirli, Tanil
FA  - Odek, Caglar
FA  - Ucar, Tayfun
FA  - Kansu, Aydan
IN  - Tutar,Ercan. Department of Pediatric Cardiology, Ankara University Medical School, Ankara, Turkey.
IN  - Ciftci,Omer. Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
IN  - Fitoz,Suat. Department of Pediatric Radiology, Ankara University Medical School, Ankara, Turkey.
IN  - Kendirli,Tanil. Department of Pediatric Intensive Care, Ankara University Medical School, Ankara, Turkey.
IN  - Odek,Caglar. Diyarbakir Children's Hospital, Diyarbakir, Turkey.
IN  - Ucar,Tayfun. Department of Pediatric Cardiology, Ankara University Medical School, Ankara, Turkey.
IN  - Kansu,Aydan. Department of Pediatric Gastroenterology, Ankara University Medical School, Ankara, Turkey.
TI  - Lipomatous hypertrophy of the interatrial septum in a child with atrial tachycardia.
SO  - Pediatrics International. 58(6):523-525, 2016 Jun.
AS  - Pediatr Int. 58(6):523-525, 2016 Jun.
NJ  - Pediatrics international : official journal of the Japan Pediatric Society
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - db6, 100886002
KW  - CT;  arrhythmia;  echocardiography;  interatrial septum;  lipomatous hypertrophy
AB  - A 13-year-old girl who had been on home parenteral nutrition for 6 months has been presented with multifocal atrial tachycardia and atrial fibrillation. Echocardiography and multislice computed tomography showed fat accumulation on the interatrial septum. Lipomatous hypertrophy of the interatrial septum has never been reported in children.Copyright © 2016 Japan Pediatric Society.
ES  - 1442-200X
IL  - 1328-8067
DO  - http://dx.doi.org/10.1111/ped.12917
PT  - CASE REPORTS
LG  - English
DP  - 2016 Jun
DC  - 20160620
YR  - 2016
RD  - 20160620
UP  - 20160622
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27322862

<1050. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27236656
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Kataoka N
AU  - Nishida K
AU  - Kinoshita K
AU  - Sakamoto T
AU  - Nakatani Y
AU  - Tsujino Y
AU  - Mizumaki K
AU  - Inoue H
AU  - Kinugawa K
FA  - Kataoka, Naoya
FA  - Nishida, Kunihiro
FA  - Kinoshita, Koshi
FA  - Sakamoto, Tamotsu
FA  - Nakatani, Yosuke
FA  - Tsujino, Yasushi
FA  - Mizumaki, Koichi
FA  - Inoue, Hiroshi
FA  - Kinugawa, Koichiro
IN  - Kataoka,Naoya. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
IN  - Nishida,Kunihiro. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. knishida@med.u-toyama.ac.jp.
IN  - Kinoshita,Koshi. Department of Legal Medicine, University of Toyama, Toyama, Japan.
IN  - Sakamoto,Tamotsu. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
IN  - Nakatani,Yosuke. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
IN  - Tsujino,Yasushi. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
IN  - Mizumaki,Koichi. Clinical Research and Ethics Center, University of Toyama, Toyama, Japan.
IN  - Inoue,Hiroshi. Saiseikai Toyama Hospital, Toyama, Japan.
IN  - Kinugawa,Koichiro. Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
TI  - Effect of irbesartan on development of atrial fibrosis and atrial fibrillation in a canine atrial tachycardia model with left ventricular dysfunction, association with p53.
SO  - Heart & Vessels. , 2016 May 28.
AS  - Heart Vessels. , 2016 May 28.
NJ  - Heart and vessels
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - her, 8511258
KW  - Angiotensin II;  Remodeling;  TGF-beta1;  p53
AB  - Effects of an angiotensin II receptor blocker, irbesartan (IRB), on the development of atrial fibrosis and atrial fibrillation (AF) were assessed in a canine model of atrial tachycardia remodeling (ATR) with left ventricular dysfunction, together with its possible association with involvement of p53. Atrial tachypacing (400 bpm for 4 weeks) was used to induce ATR in beagles treated with placebo (ATR-dogs, n = 6) or irbesartan (IRB-dogs, n = 5). Non-paced sham dogs served as control (Control-dogs, n = 4). ATR- and IRB-dogs developed tachycardia-induced left ventricular dysfunction. Atrial effective refractory period (AERP) shortened (83 +/- 5 ms, p < 0.05), inter-atrial conduction time prolonged (72 +/- 2 ms, p < 0.05), and AF duration increased (29 +/- 5 s, p < 0.05 vs. baseline) after 4 weeks in ATR-dogs. ATR-dogs also had a larger area of atrial fibrous tissue (5.2 +/- 0.5 %, p < 0.05 vs. Control). All these changes, except for AERP, were attenuated in IRB-dogs (92 +/- 3 ms, 56 +/- 3 ms, 9 +/- 5 s, and 2.5 +/- 0.7 %, respectively; p < 0.05 vs. ATR for each). In ATR-dogs, p53 expression in the left atrium decreased by 42 % compared with Control-dogs (p < 0.05); however, it was highly expressed in IRB-dogs (+89 % vs. ATR). Transforming growth factor (TGF)-beta1 expression was enhanced in ATR-dogs (p < 0.05 vs. Control) but reduced in IRB-dogs (p < 0.05 vs. ATR). Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.
ES  - 1615-2573
IL  - 0910-8327
DO  - http://dx.doi.org/10.1007/s00380-016-0853-7
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016528
DP  - 2016 May 28
DC  - 20160529
YR  - 2016
RD  - 20160529
UP  - 20160530
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27236656

<1051. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27214299
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Anabtawi A
AU  - Miles JM
FA  - Anabtawi, Abeer
FA  - Miles, John M
IN  - Anabtawi,Abeer. From: University of Kansas School of Medicine, Division of Endocrinology, Metabolism and Genetics, 3901 Rainbow Blvd. Kansas City, KS 66103.
IN  - Miles,John M. From: University of Kansas School of Medicine, Division of Endocrinology, Metabolism and Genetics, 3901 Rainbow Blvd. Kansas City, KS 66103.
TI  - METFORMIN: NON-GLYCEMIC EFFECTS AND POTENTIAL NOVEL INDICATIONS.
SO  - Endocrine Practice. , 2016 May 23.
AS  - Endocr Pract. , 2016 May 23.
NJ  - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 9607439, dy1
AB  - Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes because of its apparent robust effects in reducing cardiovascular risk. The United Kingdom Prospective Diabetes Study suggests that metformin reduces the risk of myocardial infarction, and more recent retrospective studies have shown an association between metformin and a reduction in stroke, atrial fibrillation and all-cause mortality. The mechanism(s) explaining these putative benefits are not clear but may involve decreased energy intake (with attendant weight loss), improvement in lipids, and lowering of blood pressure; a review of selected literature suggests that metformin lowers blood pressure when it is elevated, but not when it is normal. Metformin appears to be safe when given to patients with Stage 3 chronic kidney disease (CKD-3). In addition, there is evidence that individuals with CKD-3, who are at increased cardiovascular risk, stand to benefit from metformin therapy. Lactic acidosis is an extremely remote and probably avoidable risk; measurement of plasma metformin levels and more frequent monitoring of renal function may be useful in selected patients with CKD-3 who are treated with metformin. Finally, there is evidence that metformin is safe in patients with heart failure; metformin therapy is associated with a reduction in newly incident heart failure and in heart failure mortality.
ES  - 1934-2403
IL  - 1530-891X
DO  - http://dx.doi.org/10.4158/EP151145.RAR
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016523
DP  - 2016 May 23
DC  - 20160523
YR  - 2016
RD  - 20160523
UP  - 20160525
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27214299

<1052. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27189904
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Pfeilschifter W
AU  - Steinstraesser T
AU  - Paulus P
AU  - Zeiner PS
AU  - Bohmann F
AU  - Theisen A
AU  - Lindhoff-Last E
AU  - Penski C
AU  - Wagner M
AU  - Mittelbronn M
AU  - Foerch C
FA  - Pfeilschifter, Waltraud
FA  - Steinstraesser, Thurid
FA  - Paulus, Patrick
FA  - Zeiner, Pia Susan
FA  - Bohmann, Ferdinand
FA  - Theisen, Alf
FA  - Lindhoff-Last, Edelgard
FA  - Penski, Cornelia
FA  - Wagner, Marlies
FA  - Mittelbronn, Michel
FA  - Foerch, Christian
IN  - Pfeilschifter,Waltraud. Department of Neurology, Goethe-University, Frankfurt am Main, Germany.
IN  - Steinstraesser,Thurid. Department of Neurology, Goethe-University, Frankfurt am Main, Germany.
IN  - Paulus,Patrick. Department of Anesthesiology and Operative Intensive Care Medicine, Kepler University Hospital, Linz, Austria.
IN  - Zeiner,Pia Susan. Department of Neurology, Goethe-University, Frankfurt am Main, Germany.
IN  - Bohmann,Ferdinand. Department of Neurology, Goethe-University, Frankfurt am Main, Germany.
IN  - Theisen,Alf. Zentrale Forschungseinheit, Goethe-University, Frankfurt am Main, Germany.
IN  - Lindhoff-Last,Edelgard. Department of Internal Medicine, Goethe-University, Frankfurt am Main, Germany CCB Coagulation Research Center, Bethanien Hospital, Frankfurt am Main, Germany.
IN  - Penski,Cornelia. Neurological Institute (Edinger Institute), Goethe-University, Frankfurt am Main, Germany.
IN  - Wagner,Marlies. Institute of Neuroradiology, Goethe-University, Frankfurt am Main, Germany.
IN  - Mittelbronn,Michel. Neurological Institute (Edinger Institute), Goethe-University, Frankfurt am Main, Germany.
IN  - Foerch,Christian. Department of Neurology, Goethe-University, Frankfurt am Main, Germany foerch@em.uni-frankfurt.de.
TI  - Risk of long-term anticoagulation under sustained severe arterial hypertension: A translational study comparing warfarin and the new oral anticoagulant apixaban.
SO  - Journal of Cerebral Blood Flow & Metabolism. , 2016 Apr 11.
AS  - J Cereb Blood Flow Metab. , 2016 Apr 11.
NJ  - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - hnl, 8112566
KW  - Antithrombotics;  animal model;  brain ischemia;  hypertension;  intracerebral hemorrhage
AB  - New oral anticoagulants for the prevention of stroke and systemic embolism in patients with atrial fibrillation have recently been introduced. In this translational study, we explored the risk of long-term anticoagulation on intracerebral hemorrhage under sustained severe arterial hypertension. We initiated anticoagulation with warfarin or apixaban in spontaneously hypertensive rats prone to develop severe hypertension and subsequent intracerebral bleeding complications. A non-anticoagulated group served as control. During an 11-week-study period, blood pressure, anticoagulation parameters, and clinical status were determined regularly. The incidence of histopathologically proven intracerebral hemorrhage was defined as the primary endpoint. Both warfarin and apixaban anticoagulation was fairly stable during the study period, and all rats developed severe hypertension. Intracerebral hemorrhage was determined in 29% (4/14) of warfarin rats and in 10% (1/10) of apixaban rats. Controls did not show cerebral bleeding complications (chi-square not significant). Mortality rate at study termination was 33% (2/6) in controls, 43% (6/14) in the warfarin group, and 60% (6/10) in the apixaban group. Animals died from extracerebral complications in most cases. Our study describes an experimental intracerebral hemorrhage model in the context of sustained hypertension and long-term anticoagulation. Extracerebral bleeding complications occurred more often in warfarin-treated animals compared with apixaban and control rats.Copyright © The Author(s) 2016.
ES  - 1559-7016
IL  - 0271-678X
DO  - http://dx.doi.org/10.1177/0271678X16642443
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016411
DP  - 2016 Apr 11
DC  - 20160518
YR  - 2016
RD  - 20160518
UP  - 20160520
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27189904

<1053. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 27100358
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Bo M
AU  - Li Puma F
AU  - Badinella Martini M
AU  - Falcone Y
AU  - Iacovino M
AU  - Grisoglio E
AU  - Menditto E
AU  - Fonte G
AU  - Brunetti E
AU  - Isaia GC
AU  - D'Ascenzo F
AU  - Gaita F
FA  - Bo, Mario
FA  - Li Puma, Federica
FA  - Badinella Martini, Marco
FA  - Falcone, Yolanda
FA  - Iacovino, Marina
FA  - Grisoglio, Enrica
FA  - Menditto, Elena
FA  - Fonte, Gianfranco
FA  - Brunetti, Enrico
FA  - Isaia, Giovanni Carlo
FA  - D'Ascenzo, Fabrizio
FA  - Gaita, Fiorenzo
IN  - Bo,Mario. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Li Puma,Federica. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Badinella Martini,Marco. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Falcone,Yolanda. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy. yolanda.falcone@yahoo.it.
IN  - Iacovino,Marina. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Grisoglio,Enrica. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Menditto,Elena. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Fonte,Gianfranco. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Brunetti,Enrico. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - Isaia,Giovanni Carlo. SCDU Geriatria e Malattie Metaboliche dell'Osso, Citta della Salute e della Scienza-Molinette., Corso Bramante 88, 10126, Turin, Italy.
IN  - D'Ascenzo,Fabrizio. SCDU Cardiologia; Citta della Salute e della Scienza-Molinette., C.so Bramante 88, 10126, Turin, Italy.
IN  - Gaita,Fiorenzo. SCDU Cardiologia; Citta della Salute e della Scienza-Molinette., C.so Bramante 88, 10126, Turin, Italy.
TI  - Effects of oral anticoagulant therapy in older medical in-patients with atrial fibrillation: a prospective cohort observational study.
SO  - Aging-Clinical & Experimental Research. , 2016 Apr 21.
AS  - Aging Clin Exp Res. , 2016 Apr 21.
NJ  - Aging clinical and experimental research
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101132995
KW  - Anticoagulant therapy;  Atrial fibrillation;  Elderly;  Propensity score matching
AB  - BACKGROUND: Uncertainties about efficacy and safety of oral anticoagulant therapy (OAT) among older and frail medical patients with atrial fibrillation (AF) largely contribute to under-prescription of these drugs.
AB  - AIMS: In this prospective observational cohort study, we investigated mortality, and ischemic and hemorrhagic events, in hospital-discharged older patients with AF.
AB  - METHODS: Stroke and bleeding risk were evaluated using CHA2DS2-VASC and HAS-BLED scores. Comorbidity, frailty, cognitive and nutritional status and functional autonomy were evaluated using standardized scales. Independent associations between clinical variables, including OAT use, and all-cause mortality, fatal and non-fatal ischemic and hemorrhagic events, were evaluated. Further clinical outcomes comparison between patients treated with OAT and those untreated was performed after adjustment for significant differences in patient baseline characteristics with propensity score matching.
AB  - RESULTS: Of 452 patients included (mean age 81.6 years, 54.9 % women, roughly 30 % cognitively impaired and/or functionally dependent, mean CHA2DS2-VASC and HAS-BLED scores 4.6 and 2.8, respectively), 151 (33.4 %) died during a mean follow-up period of 300.5 days; ischemic and hemorrhagic stroke occurred in 4.0 and 0.4 % of patients, respectively, and major bleedings in 6.2 %.
AB  - DISCUSSION: After multivariate analysis, OAT at discharge was associated with lower overall mortality and reduced occurrence of ischemic stroke, the first finding being confirmed in propensity score matched analysis.
AB  - CONCLUSIONS: Among older vulnerable AF patients with high post discharge death rate, OAT was associated, among other multiple factors, with reduced mortality and lower occurrence of ischemic stroke.
ES  - 1720-8319
IL  - 1594-0667
DO  - http://dx.doi.org/10.1007/s40520-016-0569-7
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016421
DP  - 2016 Apr 21
DC  - 20160421
YR  - 2016
RD  - 20160423
UP  - 20160517
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27100358

<1054. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26988835
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Stacy Z
AU  - Richter S
FA  - Stacy, Zachary
FA  - Richter, Sara
IN  - Stacy,Zachary. St Louis College of Pharmacy, St Louis, MO, USA zachary.stacy@stlcop.edu.
IN  - Richter,Sara. St Louis College of Pharmacy, St Louis, MO, USA.
TI  - Practical Considerations for the Use of Direct Oral Anticoagulants in Patients With Atrial Fibrillation.
SO  - Clinical & Applied Thrombosis/Hemostasis. , 2016 Mar 17.
AS  - Clin Appl Thromb Hemost. , 2016 Mar 17.
NJ  - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - dav, 9508125
KW  - apixaban;  dabigatran;  direct oral anticoagulants;  edoxaban;  rivaroxaban;  target-specific oral anticoagulants
AB  - Atrial fibrillation (AF) is a significant risk factor for stroke and peripheral thromboembolic events (TEs). Preventing blood clots in the heart to reduce stroke and TE risk is a key goal of AF therapy. Traditional stroke risk assessment tools for patients with nonvalvular AF include the CHADS2 and CHA(2)DS(2)-VASc scores, while long-term outcome data with the newer direct oral anticoagulants (DOACs) are emerging. The goals of this review were to assess traditional therapies and existing treatment guidelines and to discuss key pharmacologic properties of the DOACS, noting how these may benefit at-risk patients with AF. This narrative review was developed on the basis of the authors' clinical knowledge, extensive reading of the literature, and broad pharmacy experience in the management of patients with AF. Limitations of oral vitamin K antagonists (VKAs) include slow onset of action, the need for regular monitoring of their anticoagulation effect, significant food and drug interactions, and unpredictable dose-response properties. Key clinical trial data led to the approvals of apixaban, dabigatran etexilate, edoxaban, and rivaroxaban in the United States to reduce the risk of stroke and systemic embolism in patients with nonvalvular AF. With predictable pharmacologic properties and limited drug and/or dietary interactions, the DOACs offer several benefits over traditional oral anticoagulation therapy with VKA. However, they have limitations, including the absence of immediate reversal agents and limited options for monitoring their anticoagulation effects in clinical practice. As experience with the use of DOACs grows, optimized treatment regimens and improved patient care are expected.Copyright © The Author(s) 2016.
ES  - 1938-2723
IL  - 1076-0296
DO  - http://dx.doi.org/10.1177/1076029616634886
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016317
DP  - 2016 Mar 17
DC  - 20160318
YR  - 2016
RD  - 20160319
UP  - 20160517
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26988835

<1055. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26941340
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Palmisano P
AU  - Aspromonte V
AU  - Ammendola E
AU  - Dell'era G
AU  - Ziacchi M
AU  - Guerra F
AU  - Aquilani S
AU  - Maglia G
AU  - Del Giorno G
AU  - Giubertoni A
AU  - Boriani G
AU  - Capucci A
AU  - Pietro Ricci R
AU  - Accogli M
AU  - Italian Association of Arrhythmology and Cardiac Pacing (AIAC)
FA  - Palmisano, Pietro
FA  - Aspromonte, Vittorio
FA  - Ammendola, Ernesto
FA  - Dell'era, Gabriele
FA  - Ziacchi, Matteo
FA  - Guerra, Federico
FA  - Aquilani, Stefano
FA  - Maglia, Giampiero
FA  - Del Giorno, Giuseppe
FA  - Giubertoni, Ailia
FA  - Boriani, Giuseppe
FA  - Capucci, Alessandro
FA  - Pietro Ricci, Renato
FA  - Accogli, Michele
FA  - Italian Association of Arrhythmology and Cardiac Pacing (AIAC)
IN  - Palmisano,Pietro. Cardiology Unit, 'Card. G. Panico' Hospital, Via S. Pio X, 4, 73039 Tricase, Italy dr.palmisano@libero.it.
IN  - Aspromonte,Vittorio. Cardiology - Coronary Care Unit, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
IN  - Ammendola,Ernesto. Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, Italy.
IN  - Dell'era,Gabriele. Division of Cardiology, University of Eastern Piedmont, Maggiore della Carita Hospital, Novara, Italy.
IN  - Ziacchi,Matteo. Institute of Cardiology, University of Bologna, S. Orsola-Malpighi University Hospital, Bologna, Italy.
IN  - Guerra,Federico. Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital 'Umberto I - Lancisi - Salesi', Ancona, Italy.
IN  - Aquilani,Stefano. Department of Cardiology, San Filippo Neri Hospital, Rome, Italy.
IN  - Maglia,Giampiero. Cardiology - Coronary Care Unit, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
IN  - Del Giorno,Giuseppe. Department of Cardiology, Monaldi Hospital, Second University of Naples, Naples, Italy.
IN  - Giubertoni,Ailia. Division of Cardiology, University of Eastern Piedmont, Maggiore della Carita Hospital, Novara, Italy.
IN  - Boriani,Giuseppe. Institute of Cardiology, University of Bologna, S. Orsola-Malpighi University Hospital, Bologna, Italy Cardiology Department, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy.
IN  - Capucci,Alessandro. Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital 'Umberto I - Lancisi - Salesi', Ancona, Italy.
IN  - Pietro Ricci,Renato. Department of Cardiology, San Filippo Neri Hospital, Rome, Italy.
IN  - Accogli,Michele. Cardiology Unit, 'Card. G. Panico' Hospital, Via S. Pio X, 4, 73039 Tricase, Italy.
TI  - Effect of fixed-rate vs. rate-RESPONSIve pacing on exercise capacity in patients with permanent, refractory atrial fibrillation and left ventricular dysfunction treated with atrioventricular junction aBLation and bivEntricular pacing (RESPONSIBLE): a prospective, multicentre, randomized, single-blind study.
SO  - Europace. , 2016 Mar 3.
AS  - Europace. , 2016 Mar 3.
NJ  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - dxd, 100883649
KW  - Ablate and pace;  Atrial fibrillation;  Cardiac resynchronization therapy;  Rate-responsive
AB  - AIMS: Atrioventricular junction (AVJ) ablation followed by biventricular pacing is an established strategy for improving symptoms and morbidity in patients with permanent atrial fibrillation (AF), reduced left ventricular ejection fraction (LVEF), and uncontrolled ventricular rate. There is no clear evidence that such patients benefit from rate-responsive (RR) pacing.
AB  - METHODS AND RESULTS: This prospective, randomized, single-blind, multicentre study was designed as an intra-patient comparison and enrolled 60 patients (age 69.5 +/- 11.8 years, males 63.3%, NYHA 3.0 +/- 0.6) with refractory AF and reduced LVEF (mean 32.4 +/- 8.3%) treated with AVJ ablation and biventricular pacing. Two 6-minute walking tests (6MWT) were performed 1 week apart: one during VVI 70/min biventricular pacing and the other during VVIR 70-130/min biventricular pacing; patients were randomly and blindly assigned to Group A (n = 29, first 6MWT in VVIR mode) or B (n = 31, first 6MWT in VVI mode). Rate-responsive activation determined an increase of 18.8 +/- 24.4 m in the distance walked during the 6MWT (P < 0.001). The increase was similar in both groups (P = 0.571). A >5% increase in the distance walked was observed in 76.7% of patients. The increase in the distance walked was linearly correlated with the increase in heart rate recorded during the 6MWT in the VVIR mode (r = 0.54; P < 0.001).
AB  - CONCLUSION: In permanent AF patients with uncontrolled rate and reduced LVEF who had undergone AVJ ablation and biventricular pacing, RR pacing yields a significant gain in exercise capacity, which seems to be related to the RR-induced frequency during effort.Copyright Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.
ES  - 1532-2092
IL  - 1099-5129
DO  - http://dx.doi.org/10.1093/europace/euw035
PT  - JOURNAL ARTICLE
LG  - English
EP  - 201633
DP  - 2016 Mar 3
DC  - 20160304
YR  - 2016
RD  - 20160305
UP  - 20160517
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26941340

<1056. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26976659
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Wahlstrom M
AU  - Rydell Karlsson M
AU  - Medin J
AU  - Frykman V
FA  - Wahlstrom, Maria
FA  - Rydell Karlsson, Monica
FA  - Medin, Jorgen
FA  - Frykman, Viveka
IN  - Wahlstrom,Maria. Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden Sophiahemmet University, Sweden maria.wahlstrom@ds.se.
IN  - Rydell Karlsson,Monica. Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden Sophiahemmet University, Sweden.
IN  - Medin,Jorgen. Department of Clinical Sciences, Danderyd Hospital, Division of Internal Medicine, Karolinska Institutet, Stockholm, Sweden Sophiahemmet University, Sweden.
IN  - Frykman,Viveka. Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden Department of Clinical Sciences, Danderyd Hospital, Division of Internal Medicine, Karolinska Institutet, Stockholm, Sweden.
TI  - Effects of yoga in patients with paroxysmal atrial fibrillation - a randomized controlled study.
SO  - European Journal of Cardiovascular Nursing. , 2016 Mar 14.
AS  - EUR J CARDIOVASC NURS. , 2016 Mar 14.
NJ  - European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 101128793
KW  - Paroxysmal atrial fibrillation;  blood pressure;  heart rate;  quality of life;  yoga
AB  - BACKGROUND: Patients with atrial fibrillation often have an impaired quality of life (QoL). Practising yoga may decrease stress and have positive effects on mental and physical health. The aim of this study was to investigate whether yoga can improve QoL and decrease blood pressure and heart rate in patients with paroxysmal atrial fibrillation (PAF).
AB  - METHODS: In this pilot study, 80 patients diagnosed with PAF were randomized to standard treatment (control group, n=40) or standard treatment in combination with yoga (yoga group, n=40) during a 12-week period. QoL, blood pressure and heart rate were evaluated at baseline and at the end of the study (12 (+2) weeks). EuroQoL-5D (EQ-5D) Visual Analogue Scale (VAS) and the two dimensions in Short-Form Health Survey (SF-36) were used to evaluate QoL.
AB  - RESULTS: At baseline there was a significant difference in QoL between the groups in EQ-5D VAS- scale (p=0.02) and SF-36 mental health score (p<0.001) in which the control group had higher scores. At the end of the study, the yoga group averaged higher SF-36 mental health scores. There was a significant difference between the two groups (p=0.016), but no differences in EQ-5D VAS- scale and physiological health score was seen between the two groups. At the end of the study, the yoga group had significantly lower heart rate (p=0.024) and systolic (p=0.033) and diastolic blood pressure (p<0.001) compared to the control group.
AB  - CONCLUSIONS: Yoga with light movements and deep breathing may lead to improved QoL, lower blood pressure and lower heart rate in patients with PAF compared to a control group. Yoga could be a complementary treatment method to standard therapy.Copyright © The European Society of Cardiology 2016.
ES  - 1873-1953
IL  - 1474-5151
DO  - http://dx.doi.org/10.1177/1474515116637734
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016314
DP  - 2016 Mar 14
DC  - 20160315
YR  - 2016
RD  - 20160316
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26976659

<1057. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26752626
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Gabrielli L
AU  - Bijnens BH
AU  - Brambila C
AU  - Duchateau N
AU  - Marin J
AU  - Sitges-Serra I
AU  - Mont L
AU  - Brugada J
AU  - Sitges M
FA  - Gabrielli, L
FA  - Bijnens, B H
FA  - Brambila, C
FA  - Duchateau, N
FA  - Marin, J
FA  - Sitges-Serra, I
FA  - Mont, L
FA  - Brugada, J
FA  - Sitges, M
IN  - Gabrielli,L. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
IN  - Gabrielli,L. Advanced Center for Chronic Diseases, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
IN  - Bijnens,B H. Universitat Pompeu Fabra, Barcelona, Spain.
IN  - Bijnens,B H. ICREA, Barcelona, Spain.
IN  - Brambila,C. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
IN  - Duchateau,N. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
IN  - Duchateau,N. Universitat Pompeu Fabra, Barcelona, Spain.
IN  - Marin,J. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
IN  - Sitges-Serra,I. Consell Catala de l'Esport, Barcelona, Spain.
IN  - Sitges-Serra,I. Imesport, Teknon Clinic, Barcelona, Spain.
IN  - Mont,L. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
IN  - Brugada,J. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
IN  - Sitges,M. IDIBAPS (IDIBAPS-Institut d'Investigacions Biomediques August Pi i Sunyer), Thorax Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
TI  - Differential atrial performance at rest and exercise in athletes: Potential trigger for developing atrial dysfunction?.
SO  - Scandinavian Journal of Medicine & Science in Sports. , 2016 Jan 10.
AS  - Scand J Med Sci Sports. , 2016 Jan 10.
NJ  - Scandinavian journal of medicine & science in sports
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - 9111504, cac
KW  - Atrial function;  athletes;  atrial arrhythmia;  imaging stress test
AB  - Highly trained athletes show an increased risk of atrial arrhythmias. Little is known about atrial volumes and function during exercise in this population. Our aim was to analyze atrial size and contractile function during exercise. Fifty endurance athletes with 11 +/- 8 h of training per week and 30 sedentary control subjects were included. Echocardiography was performed at baseline and during exercise. Left (LA) and right atrial (RA) size and function were assessed by two-dimensional echocardiography. Peak negative strain (Sa) during atrial contraction and active atrial emptying volume (AEV) were measured. Athletes and control subjects showed a significant increment of deformation and AEV of both atria with exercise (P < 0.01 vs baseline for LA and RA). Among athletes, a subgroup with significant LA (n = 8)/RA (n = 15) dilatation (>40 mL/m(2) ) showed a significantly lower increment in AEV with exercise (LAAEV: 1.4 +/- 1.1 mL/m(2) vs 2.1 +/- 0.9 mL/m(2) , P = 0.04; RAAEV: 0.9 +/- 0.8 mL/m(2) vs 2.3 +/- 1.1 mL/m(2) , P < 0.01) and lower increment in deformation vs other athletes (LASa: -3.2 +/- 2.9% vs -9.5 +/- 4.4%, P < 0.01; RASa: -2.5 +/- 3.3% vs. -9.8 +/- 3.3%, P < 0.01). During exercise, active atrial strain increases, but less in athletes compared to controls, but due to larger atrial volumes, they reached similar increases in atrial emptying volume. However, this overall lesser deformation increases from a subgroup with significant atrial dilatation showing impairment in atrial contractile reserve.Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ES  - 1600-0838
IL  - 0905-7188
DO  - http://dx.doi.org/10.1111/sms.12610
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016110
DP  - 2016 Jan 10
DC  - 20160111
YR  - 2016
RD  - 20160112
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26752626

<1058. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26817809
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Zeren M
AU  - Demir R
AU  - Yigit Z
AU  - Gurses HN
FA  - Zeren, Melih
FA  - Demir, Rengin
FA  - Yigit, Zerrin
FA  - Gurses, Hulya N
IN  - Zeren,Melih. Department of Physiotherapy and Rehabilitation, Bezmialem Vakif University, Istanbul, Turkey.
IN  - Demir,Rengin. Department of Cardiology, Istanbul University, Istanbul, Turkey rengindemir@yahoo.com.
IN  - Yigit,Zerrin. Department of Cardiology, Istanbul University, Istanbul, Turkey.
IN  - Gurses,Hulya N. Department of Physiotherapy and Rehabilitation, Bezmialem Vakif University, Istanbul, Turkey.
TI  - Effects of inspiratory muscle training on pulmonary function, respiratory muscle strength and functional capacity in patients with atrial fibrillation: A randomized controlled trial.
SO  - Clinical Rehabilitation. , 2016 Jan 27.
AS  - Clin Rehabil. , 2016 Jan 27.
NJ  - Clinical rehabilitation
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - cr7, 8802181
KW  - 6-minute walk test;  Atrial fibrillation;  maximal inspiratory pressure;  pulmonary function test;  respiratory muscle training
AB  - OBJECTIVE: To investigate the effects of inspiratory muscle training on pulmonary function, respiratory muscle strength and functional capacity in patients with atrial fibrillation.
AB  - DESIGN: Prospective randomized controlled single-blind study.
AB  - SETTING: Cardiology department of a university hospital.
AB  - SUBJECTS: A total of 38 patients with permanent atrial fibrillation were randomly allocated to either a treatment group (n=19; age 66.2years (8.8)) or a control group (n=19; age 67.1years (6.4)).
AB  - METHODS: The training group received inspiratory muscle training at 30% of maximal inspiratory pressure for 15minutes twice a day, 7days a week, for 12weeks alongside the standard medical treatment. The control group received standard medical treatment only. Spirometry, maximal inspiratory and expiratory pressures and 6-minute walking distance was measured at the beginning and end of the study.
AB  - RESULTS: There was a significant increase in maximal inspiratory pressure (27.94cmH2O (8.90)), maximal expiratory pressure (24.53cmH2O (10.34)), forced vital capacity (10.29% (8.18) predicted), forced expiratory volume in one second (13.88% (13.42) predicted), forced expiratory flow 25%-75% (14.82% (12.44) predicted), peak expiratory flow (19.82% (15.62) predicted) and 6-minute walking distance (55.53m (14.13)) in the training group (p<0.01). No significant changes occurred in the control group (p>0.05).
AB  - CONCLUSION: Inspiratory muscle training can improve pulmonary function, respiratory muscle strength and functional capacity in patients with atrial fibrillation.Copyright © The Author(s) 2016.
ES  - 1477-0873
IL  - 0269-2155
DO  - http://dx.doi.org/10.1177/0269215515628038
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2016127
DP  - 2016 Jan 27
DC  - 20160128
YR  - 2016
RD  - 20160129
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26817809

<1059. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26426216
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Hoegh V
AU  - Lundbye-Christensen S
AU  - Delmar C
AU  - Frederiksen K
AU  - Riahi S
AU  - Overvad K
FA  - Hoegh, Vibeke
FA  - Lundbye-Christensen, Soeren
FA  - Delmar, Charlotte
FA  - Frederiksen, Kirsten
FA  - Riahi, Sam
FA  - Overvad, Kim
IN  - Hoegh,Vibeke. Aalborg Atrial Fibrillation Study Group, Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
IN  - Hoegh,Vibeke. Doctoral School of Medicine, Biomedical Science and Technology, Faculty of Medicine, Aalborg University, Aalborg East, Denmark.
IN  - Lundbye-Christensen,Soeren. Aalborg Atrial Fibrillation Study Group, Department of Cardiology and Unit of Clinical Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
IN  - Delmar,Charlotte. Department of Nursing Science, Health Faculty, Institute of Public Health, Aarhus University, Aarhus C, Denmark.
IN  - Delmar,Charlotte. Health Faculty, Aalborg University Denmark, Aalborg East, Denmark.
IN  - Delmar,Charlotte. University College Diakonova, Oslo, Norway.
IN  - Frederiksen,Kirsten. Department of Nursing Science, Health Faculty, Institute of Public Health, Aarhus University, Aarhus C, Denmark.
IN  - Riahi,Sam. Aalborg Atrial Fibrillation Study Group, Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
IN  - Overvad,Kim. Aalborg Atrial Fibrillation Study Group, Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
IN  - Overvad,Kim. Department of Public Health, Section for Epidemiology, Faculty of Health Sciences, Aarhus University, Aarhus C, Denmark.
TI  - Association between the diagnosis of atrial fibrillation and aspects of health status: a Danish cross-sectional study.
SO  - Scandinavian Journal of Caring Sciences. , 2015 Oct 1.
AS  - Scand J Caring Sci. , 2015 Oct 1.
NJ  - Scandinavian journal of caring sciences
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - sjo, 8804206
KW  - Short Form 36v2;  atrial fibrillation;  cross-sectional study;  health status;  health-related quality of life;  individualised care;  patient-reported outcome;  tailored nursing
AB  - BACKGROUND: Caring for patients living with atrial fibrillation (AF) is expected to be an increasing challenge for the healthcare sector in the future. Inconclusive results on self-reported health-related quality of life and health status in patients living with AF have previously been reported, ranging from being similar to those observed in patients who have sustained and survived a myocardial infarction to not being different from those of healthy subjects. In these studies, gender differences were not taken into account.
AB  - AIM AND OBJECTIVE: To investigate the association between the diagnosis of atrial fibrillation and self-reported health status.
AB  - DESIGN: An observational, cross-sectional study was conducted using data from the Danish Diet, Cancer and Health cohort. Information on health status was obtained using the Danish version of the Short Form 36 version 2 questionnaire. The analyses were stratified on gender. In adjusted analysis, we considered potential confounding from comorbidity expressed by the Charlson Comorbidity Index and effect modification by age.
AB  - ETHICAL APPROVAL: The local ethical committees of Copenhagen and Frederiksberg municipalities (Approval no.: (KF) 01-345/93) approved the study.
AB  - RESULTS: We included 42 598 participants of whom 873 had a diagnosis of AF and/or atrial flutter. We found a lower adjusted physical component score among AF patients. No systematic differences in the mental component score (MCS) were observed.
AB  - CONCLUSION: Participants diagnosed with AF report a clinically and statistically significantly lower physical health component score. No systematic differences in the MCS were found when comparing with the remaining participants in the cohort. As healthcare professionals caring for patients living with AF are not always expecting patients living with AF to experience a burden from their disease, the individual patients' experience of their situation, feelings, preferences, symptoms and needs leading to physical limitations should always be articulated.Copyright © 2015 Nordic College of Caring Science.
ES  - 1471-6712
IL  - 0283-9318
DO  - http://dx.doi.org/10.1111/scs.12272
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2015101
DP  - 2015 Oct 1
DC  - 20151001
YR  - 2015
RD  - 20151002
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26426216

<1060. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 26676028
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Katsikis A
AU  - Theodorakos A
AU  - Drosatos A
AU  - Konstantinou K
AU  - Papaioannou S
AU  - Koutelou M
FA  - Katsikis, Athanasios
FA  - Theodorakos, Athanasios
FA  - Drosatos, Alexandros
FA  - Konstantinou, Konstantinos
FA  - Papaioannou, Spyridon
FA  - Koutelou, Maria
IN  - Katsikis,Athanasios. Nuclear Medicine Department, Onassis Cardiac Surgery Center, Kallithea, Greece. tkatsikis@gmail.com.
IN  - Katsikis,Athanasios. Cardiology Department, 401 General Military Hospital of Athens, Athens, Greece. tkatsikis@gmail.com.
IN  - Theodorakos,Athanasios. Nuclear Medicine Department, Onassis Cardiac Surgery Center, Kallithea, Greece.
IN  - Drosatos,Alexandros. Cardiology Department, Attikon University Hospital, Athens, Greece.
IN  - Drosatos,Alexandros. Cardiology Department, 401 General Military Hospital of Athens, Athens, Greece.
IN  - Konstantinou,Konstantinos. Cardiology Department, 401 General Military Hospital of Athens, Athens, Greece.
IN  - Papaioannou,Spyridon. Nuclear Medicine Department, Onassis Cardiac Surgery Center, Kallithea, Greece.
IN  - Papaioannou,Spyridon. Cardiology Department, Athens Naval Hospital, Athens, Greece.
IN  - Koutelou,Maria. Nuclear Medicine Department, Onassis Cardiac Surgery Center, Kallithea, Greece.
TI  - Risk stratification for large artery or chronic coronary artery disease-related ischemic stroke in octogenarians undergoing exercise stress myocardial perfusion imaging: A cohort study.
SO  - Journal of Nuclear Cardiology. , 2015 Dec 16.
AS  - J Nucl Cardiol. , 2015 Dec 16.
NJ  - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - cmd, 9423534
KW  - Octogenarians;  exercise stress test;  myocardial perfusion imaging;  stroke
AB  - OBJECTIVES: To test, if in octogenarians, treadmill exercise with myocardial perfusion imaging (exercise-MPI) can risk stratify for large artery or chronic CAD-related ischemic stroke (LACCIS).
AB  - METHODS: Exercise-MPI-related data of 237 octogenarians (55% prior MI or revascularization) without previous stroke were registered and prospective follow-up was performed to document LACCIS. LACCIS was defined as acute onset of neurological symptoms with CT/MRI findings of non-lacunar-type infarcts in the absence of atrial fibrillation or intracardiac embolic sources.
AB  - RESULTS: After 7.3 years, 10 LACCIS were documented. SSS [HR 1.08 (1.02-1.13 95% CIs), SDS [HR 1.1 (1.04-1.16 95% CIs)], and non-sustained VT or transient AV block during exercise [HR 3.9 (1.7-9.0 95% CIs)] were predictors of LACCIS (P < .01 for all). A SSS threshold of 16 had 81% specificity for identification of future LACCIS and risk groups formed according to this cut-off had significantly different LACCIS-free survival (P = .015).
AB  - CONCLUSION: Exercise-MPI in octogenarians can provide risk stratification markers for LACCIS.
ES  - 1532-6551
IL  - 1071-3581
DO  - http://dx.doi.org/10.1007/s12350-015-0361-7
PT  - JOURNAL ARTICLE
LG  - English
EP  - 20151216
DP  - 2015 Dec 16
DC  - 20151217
YR  - 2015
RD  - 20151218
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26676028

<1061. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 25120610
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Chen J
AU  - Li Q
AU  - Dong R
AU  - Gao H
AU  - Peng H
AU  - Wu Y
FA  - Chen, Jinling
FA  - Li, Qingqing
FA  - Dong, Ruiqing
FA  - Gao, Huikuan
FA  - Peng, Hui
FA  - Wu, Yongquan
IN  - Chen,Jinling. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
IN  - Li,Qingqing. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
IN  - Dong,Ruiqing. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
IN  - Gao,Huikuan. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
IN  - Peng,Hui. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
IN  - Wu,Yongquan. Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
TI  - The effect of the Ras homolog gene family (Rho), member A/Rho associated coiled-coil forming protein kinase pathway in atrial fibrosis of type 2 diabetes in rats.
SO  - Experimental & Therapeutic Medicine. 8(3):836-840, 2014 Sep.
AS  - Experimental Ther. Med.. 8(3):836-840, 2014 Sep.
NJ  - Experimental and therapeutic medicine
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Print
KW  - Ras homolog gene family;  atrial arrhythmogenicity;  atrial fibrosis;  fasudil;  member A (RhoA)/Rho associated coiled-coil forming protein kinase pathway
AB  - Diabetes mellitus promotes atrial structural remodeling, thereby producing atrial arrhythmogenicity. Atrial arrhythmia can substantially increase the risk of premature death. The aim of this study was to investigate the role of Ras homolog gene family, member A (RhoA)/Rho associated coiled-coil forming protein kinase (ROCK) in atrial fibrosis in diabetic hearts, and the effects of fasudil hydrochloride hydrate on atrial fibrosis. An eight-week-old male Sprague-Dawley rat model of type 2 diabetes was established using a high-fat diet combined with streptozotocin [30 mg/kg, once, intraperitoneal (i.p.)]. Animals were randomly divided into three groups: Control rats, untreated diabetic rats that received vehicle, and treated diabetic rats that received Rho kinase inhibitor fasudil hydrochloride hydrate (10 mg/kg/day, i.p., for 14 weeks). The morphological features of atrial fibrosis were observed using Masson staining. The mRNA expression levels of RhoA, ROCK1, ROCK2, type-I and type-III procollagen were assessed with quantitative polymerase chain reaction. The protein levels of RhoA, ROCK1 and ROCK2 were evaluated using western blot analysis. The atria of untreated diabetic rats showed evident atrial fibrosis as compared to the control rats; the mRNA expression levels of RhoA, ROCK1, ROCK2, type-I and type-III procollagen were upregulated; and the protein levels of RhoA, ROCK1 and ROCK2 were increased. The treatment with fasudil hydrochloride hydrate significantly reduced atrial fibrosis, mRNA levels of RhoA, ROCK1, ROCK2, type-I and type-III procollagen, and the protein levels of RhoA, ROCK1 and ROCK2. The results suggested that RhoA/ROCK was involved in atrial fibrosis, and that fasudil hydrochloride hydrate ameliorates atrial fibrosis through the RhoA/ROCK pathway in rats with type 2 diabetes.
IS  - 1792-0981
IL  - 1792-0981
DO  - http://dx.doi.org/10.3892/etm.2014.1843
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2014714
DP  - 2014 Sep
DC  - 20140814
YR  - 2014
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=25120610

<1062. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 23170137
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Zhang XL
AU  - Wu LQ
AU  - Liu X
AU  - Yang YQ
AU  - Tan HW
AU  - Wang XH
AU  - Zhou L
AU  - Jiang WF
AU  - Li Z
FA  - Zhang, Xian-Ling
FA  - Wu, Li-Qun
FA  - Liu, Xu
FA  - Yang, Yi-Qing
FA  - Tan, Hong-Wei
FA  - Wang, Xin-Hua
FA  - Zhou, Li
FA  - Jiang, Wei-Feng
FA  - Li, Zheng
IN  - Zhang,Xian-Ling. Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University School of Medicine; ; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University;
TI  - Association of angiotensin-converting enzyme gene I/D and CYP11B2 gene -344T/C polymorphisms with lone atrial fibrillation and its recurrence after catheter ablation.
SO  - Experimental & Therapeutic Medicine. 4(4):741-747, 2012 Oct.
AS  - Experimental Ther. Med.. 4(4):741-747, 2012 Oct.
NJ  - Experimental and therapeutic medicine
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Print
AB  - The renin-angiotensin-aldosterone system (RAAS) plays a key role in atrial structural and electrical remodeling. The aim of this study was to investigate the potential associations of angiotensin-converting enzyme (ACE) gene insertion/ deletion (I/D) and aldosterone synthase (CYP11B2) gene -344T/C polymorphisms with the risk and recurrence of lone atrial fibrillation (AF). One hundred and ninety-three patients who underwent successful catheter ablation for lone AF were recruited. Two hundred and ninety-seven sinus rhythm subjects without a history of arrhythmia served as controls. The subjects were genotyped for ACE gene I/D and CYP11B2 gene -344T/C polymorphisms. Results showed that the ACE gene DD genotype and D allele were associated with a greater prevalence of lone AF (both P<0.01). In addition, the ACE gene DD genotype had a significantly larger left atrial dimension (LAD; 41.6+/-5.7 mm vs. 39.6+/-5.2 mm; P=0.043) and higher risk of AF recurrence [44.7% vs. 23.2%; odds ratio (OR), 2.68; 95% confidence interval (CI), 1.28-5.61; P=0.008] compared with the II+ID genotype in lone AF patients. After adjustment for a variety of risk factors, the ACE gene DD genotype had a 1.97-fold increased risk for lone AF (OR, 1.97; 95% CI, 1.15-3.37; P= 0.013) and 2.35-fold increased risk for AF recurrence (RR, 2.35; 95% CI, 1.10-5.04; P=0.028) compared with the ACE gene II+ID genotype. However, no correlation between the CYP11B2 gene -344T/C polymorphism and lone AF or its recurrence was observed in this cohort. In conclusion, the ACE gene DD genotype was associated with an increased incidence of lone AF and its recurrence following ablation, which was partly mediated by LAD.
IS  - 1792-0981
IL  - 1792-0981
DO  - http://dx.doi.org/10.3892/etm.2012.650
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2012731
DP  - 2012 Oct
DC  - 20121121
YR  - 2012
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=23170137

<1063. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 15935451
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Cannon RO 3rd
FA  - Cannon, Richard O 3rd
IN  - Cannon,Richard O 3rd. National Heart, Lung, and Blood Institute Head, Clinical Cardiology Section, Cardiovascular Branch National Institutes of Health, Building 10-CRC Room 5-3330, 10 Center Drive, Bethesda, MD 20892-1454, United States.
TI  - WITHDRAWN: NIH conference on dietary supplements, coagulation, and antithrombotic therapies Session V. Panel experts: Opinions and research priorities; supplements affecting antithrombotic therapies: A cardiologist's perspective. Dietary supplements and the management of atrial fibrillation.
SO  - Thrombosis Research. , 2005 May 31.
AS  - Thromb Res. , 2005 May 31.
NJ  - Thrombosis research
PI  - Journal available in: Print-Electronic
PI  - Citation processed from: Internet
JC  - vrn, 0326377
ES  - 1879-2472
IL  - 0049-3848
DO  - http://dx.doi.org/10.1016/j.thromres.2005.04.021
PT  - JOURNAL ARTICLE
LG  - English
EP  - 2005531
DP  - 2005 May 31
DC  - 20050606
YR  - 2005
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=15935451

<1064. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 11696265
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Leier CV
FA  - Leier, Carl V.
IN  - Leier,Carl V.. Division of Cardiology, Heart-Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Room 261, Columbus, OH 43210, USA. Leier.1@osu.edu
TI  - Dilated Cardiomyopathy.
SO  - Current Treatment Options in Cardiovascular Medicine. 3(6):451-462, 2001 Dec.
AS  - Curr Treat Options Cardiovasc Med. 3(6):451-462, 2001 Dec.
NJ  - Current treatment options in cardiovascular medicine
PI  - Journal available in: Print
PI  - Citation processed from: Print
JC  - 9815942
AB  - The management of patients with dilated cardiomyopathy (DCM) heart failure starts with the determination of the underlying diagnosis, definition of the hemodynamic character (eg, systolic, diastolic, valvular, right- and left-sided heart dysfunction), recognition of complicating factors (eg, atrial fibrillation, renal dysfunction), and consideration for any surgically remedial lesions (eg, severe valvular regurgitation, high-grade coronary artery occlusive disease). Angiotensin-converting enzyme inhibitors, beta-blocking agents, digoxin, and judicious diuretic administration make up the therapeutic plan for patients with symptomatic DCM heart failure. Angiotensin-converting enzymes are indicated for patients with DCM who have mild or no detectable symptoms; whether this subgroup would benefit from long-term beta-blockade remains to be established. Spirolactone also has been shown to be effective in patients with more advanced stages of heart failure. Biventricular pacing (cardiac resynchronization therapy) recently has been approved for use in patients with DCM and a left ventricular or intraventricular conduction defect and a QRS duration of longer than 140 msec. More intense pharmacotherapy, mechanical devices, and transplantation are directed at patients with severely symptomatic end-stage DCM. The effectiveness of any heart failure treatment plan is very much dependent on nonpharmacologic approaches, including dietary measures, exercise conditioning, and similar considerations, all of which are best delivered by dedicated heart failure programs.
IS  - 1092-8464
IL  - 1092-8464
PT  - JOURNAL ARTICLE
LG  - English
DP  - 2001 Dec
DC  - 200106
YR  - 2001
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=11696265

<1065. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 11416540
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Yunis NA
AU  - Petrasko MS
AU  - Cannistra LB
FA  - Yunis, Nidal A.
FA  - Petrasko, Marion S.
FA  - Cannistra, Lauralyn B.
IN  - Yunis,Nidal A.. Department of Medicine, Division of Cardiology, Memorial Hospital of Rhode Island, Brown University School of Medicine, Providence, RI.
TI  - An Elderly Man With Progressive Dyspnea on Exertion and Atrial Fibrillation as Manifestations of Senile Cardiac Amyloidosis.
SO  - American Journal of Geriatric Cardiology. 9(2):69-72, 2000 Mar.
AS  - Am J Geriatr Cardiol. 9(2):69-72, 2000 Mar.
NJ  - The American journal of geriatric cardiology
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - dz4, 9215283
AB  - Senile cardiac amyloidosis is a form of amyloidosis seen more commonly in the elderly population. It was previously believed to have no functional significance, but more recent studies suggest that it is an important cause for cardiovascular morbidity and mortality in the elderly. The diagnosis may be challenging and it is important to have a high suspicion for this disease in the proper clinical setting. A patient with cardiac amyloidosis is presented in this paper to illustrate the clinical context in which one should consider this diagnosis. Information regarding diagnostic evaluation and a brief review of senile cardiac amyloidosis is presented. (c)2000 by CVRR, Inc.
ES  - 1751-715X
IL  - 1076-7460
PT  - JOURNAL ARTICLE
LG  - English
DP  - 2000 Mar
DC  - 200120
YR  - 2000
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=11416540

<1066. >
VN  - Ovid Technologies
DB  - Ovid MEDLINE(R)
UI  - 9624105
RO  - From MEDLINE, a database of the U.S. National Library of Medicine.
ST  - Publisher
AU  - Anonymous
TI  - Lone atrial fibrillation is commoner in middle aged men who exercise vigorously.
SO  - BMJ. 316(7147):D, 1998 Jun 13.
AS  - BMJ. 316(7147):D, 1998 Jun 13.
NJ  - BMJ (Clinical research ed.)
PI  - Journal available in: Print
PI  - Citation processed from: Internet
JC  - 8900488, bmj, 101090866
ES  - 1756-1833
IL  - 0959-535X
PT  - JOURNAL ARTICLE
LG  - English
DP  - 1998 Jun 13
DC  - 199823
YR  - 1998
UP  - 20160331
XL  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=9624105