AA	Pos	Mut	baseMean	log2FoldChange	pvalue	padj	amplicon	mutation	type
V	1	A	2044.73447	0.381484915	1.05E-63	7.23E-63	1	V1A	missense
V	1	E	1024.915485	0.480136624	1.94E-36	9.75E-36	1	V1E	missense
V	1	G	167.2257473	0.439544421	1.84E-06	5.27E-06	1	V1G	missense
V	1	L	326.740076	0.37825934	4.28E-12	1.46E-11	1	V1L	missense
V	1	M	864.3707238	0.404614186	1.66E-20	6.71E-20	1	V1M	missense
H	2	R	2089.069289	0.260294417	5.13E-13	1.80E-12	1	H2R	missense
H	2	N	306.6012541	0.389144874	1.03E-14	3.82E-14	1	H2N	missense
H	2	D	169.0581866	0.568149944	1.08E-18	4.19E-18	1	H2D	missense
H	2	Q	299.9881066	0.470570143	3.15E-13	1.13E-12	1	H2Q	missense
H	2	L	918.3718501	0.426813875	1.00E-21	4.09E-21	1	H2L	missense
H	2	P	146.8021833	0.446350588	2.10E-07	6.21E-07	1	H2P	missense
H	2	Y	1338.955567	0.316500073	3.03E-23	1.27E-22	1	H2Y	missense
H	3	N	349.881664	0.347216419	9.46E-09	3.01E-08	1	H3N	missense
H	3	D	25.57849323	-1.393379529	2.99E-11	9.97E-11	1	H3D	missense
H	3	Q	741.4979458	0.297630376	3.75E-16	1.44E-15	1	H3Q	missense
H	3	L	623.1601095	0.692293273	2.76E-33	1.31E-32	1	H3L	missense
H	3	P	112.6599201	0.487652604	4.53E-08	1.38E-07	1	H3P	missense
H	3	Y	828.5269691	0.626110005	1.79E-44	9.93E-44	1	H3Y	missense
P	4	A	51.23590462	0.361877956	0.005493101	0.01336243	1	P4A	missense
P	4	R	87.59447309	0.231040728	0.018296715	0.042140837	1	P4R	missense
P	4	H	628.4824955	0.34639679	1.04E-12	3.62E-12	1	P4H	missense
P	4	S	577.3898903	0.510304504	2.24E-36	1.12E-35	1	P4S	missense
P	4	T	324.5842521	0.479853771	4.21E-10	1.39E-09	1	P4T	missense
P	5	A	80.12022953	0.732283344	1.27E-15	4.79E-15	1	P5A	missense
P	5	L	987.4500141	0.227187669	0.008438801	0.020413412	1	P5L	missense
P	5	S	961.2031164	0.579255801	9.08E-57	6.05E-56	1	P5S	missense
P	5	T	725.5459655	0.55921969	7.63E-54	4.93E-53	1	P5T	missense
S	6	P	1375.321516	-0.187820938	4.36E-09	1.41E-08	1	S6P	missense
S	6	T	644.1864079	0.28098401	2.55E-12	8.75E-12	1	S6T	missense
Y	7	N	829.3303154	0.524144579	3.51E-20	1.41E-19	1	Y7N	missense
Y	7	D	99.55829596	0.410694885	5.80E-05	1.60E-04	1	Y7D	missense
Y	7	C	1122.168578	0.129334349	6.32E-04	0.001657861	1	Y7C	missense
Y	7	H	1427.165622	0.339398578	1.36E-27	5.93E-27	1	Y7H	missense
Y	7	S	79.75210914	0.460727789	5.76E-06	1.63E-05	1	Y7S	missense
V	8	A	1607.92071	-0.200473673	9.40E-14	3.45E-13	1	V8A	missense
V	8	E	727.359431	-1.102054288	2.77E-143	3.00E-141	1	V8E	missense
V	8	G	92.66570454	-1.632880401	3.67E-67	2.65E-66	1	V8G	missense
V	8	M	1099.084237	0.156860162	7.76E-07	2.26E-06	1	V8M	missense
A	9	D	93.65653523	-1.167337235	3.66E-23	1.52E-22	1	A9D	missense
A	9	P	159.7254257	-0.400669376	3.44E-08	1.06E-07	1	A9P	missense
A	9	S	319.2266948	-0.269563775	1.27E-05	3.56E-05	1	A9S	missense
A	9	T	912.5495584	-0.539034091	9.42E-29	4.21E-28	1	A9T	missense
A	9	V	737.5258503	-0.942960417	1.99E-100	5.06E-99	1	A9V	missense
H	10	R	1467.495102	0.210716956	2.21E-08	6.89E-08	1	H10R	missense
H	10	Q	181.3159519	0.632337705	3.44E-08	1.06E-07	1	H10Q	missense
H	10	L	668.8059961	0.130037533	1.26E-04	3.46E-04	1	H10L	missense
H	10	P	87.35230857	-1.269403627	5.96E-46	3.39E-45	1	H10P	missense
H	10	Y	773.3096057	0.328653412	2.33E-12	8.08E-12	1	H10Y	missense
L	11	R	149.1706188	-0.824369125	4.94E-24	2.12E-23	1	L11R	missense
L	11	Q	804.6996521	-0.632468155	2.99E-73	2.28E-72	1	L11Q	missense
L	11	M	635.7724776	0.121033315	0.002366663	0.005978135	1	L11M	missense
L	11	P	1005.815855	-1.628766215	2.33E-124	1.26E-122	1	L11P	missense
L	11	V	41.76960653	-0.329422045	0.016762964	0.038814778	1	L11V	missense
A	12	D	57.98276088	-1.684585821	1.63E-30	7.43E-30	1	A12D	missense
A	12	G	24.10043959	-0.69365041	1.97E-04	5.30E-04	1	A12G	missense
A	12	P	61.56114756	-1.838369195	4.14E-41	2.21E-40	1	A12P	missense
A	12	S	233.4097618	-0.453465799	1.63E-13	5.87E-13	1	A12S	missense
A	12	T	787.2359715	0.081138148	0.021417455	0.049067503	1	A12T	missense
A	12	V	917.9371533	0.591236782	6.13E-45	3.45E-44	1	A12V	missense
S	13	A	101.3920459	-1.646920509	1.68E-74	1.30E-73	1	S13A	missense
S	13	L	210.48586	-2.205148303	4.96E-119	2.39E-117	1	S13L	missense
S	13	P	696.8573844	-2.499470744	3.44E-40	1.82E-39	1	S13P	missense
S	13	T	826.1904078	-0.219941128	9.61E-09	3.04E-08	1	S13T	missense
D	14	A	39.55975846	-0.890558291	7.54E-10	2.47E-09	1	D14A	missense
D	14	N	322.2588858	-0.217676196	4.12E-05	1.14E-04	1	D14N	missense
D	14	G	550.8847353	-1.484764527	3.97E-143	3.44E-141	1	D14G	missense
D	14	H	16.29310935	-0.775957584	1.33E-04	3.61E-04	1	D14H	missense
D	14	Y	89.79036731	-1.906970602	1.75E-37	8.92E-37	1	D14Y	missense
D	14	V	141.7656973	-1.63859944	7.49E-76	6.01E-75	1	D14V	missense
F	15	C	27.93209303	-3.053490907	2.99E-47	1.73E-46	1	F15C	missense
F	15	I	426.2822864	-0.777278501	7.95E-51	5.06E-50	1	F15I	missense
F	15	L	1167.335382	-0.885334312	3.12E-102	9.01E-101	1	F15L	missense
F	15	S	491.7106508	-2.966809615	1.89E-75	1.49E-74	1	F15S	missense
F	15	Y	321.9109862	-2.183687119	2.32E-56	1.52E-55	1	F15Y	missense
F	15	V	66.37523128	-1.085229809	8.07E-25	3.50E-24	1	F15V	missense
G	16	A	53.18264734	-1.868885837	6.10E-48	3.62E-47	1	G16A	missense
G	16	R	480.5703817	-3.904863153	6.97E-80	5.80E-79	1	G16R	missense
G	16	E	294.4830405	-3.263552061	1.34E-95	3.06E-94	1	G16E	missense
G	16	W	291.8071869	-2.910352162	5.98E-109	2.36E-107	1	G16W	missense
G	16	V	380.3370506	-3.170476362	3.33E-196	7.22E-194	1	G16V	missense
V	17	A	889.0346203	-1.406987197	3.44E-77	2.81E-76	1	V17A	missense
V	17	E	237.2943901	-2.819424171	2.87E-43	1.57E-42	1	V17E	missense
V	17	G	51.52806183	-2.197484815	8.61E-51	5.40E-50	1	V17G	missense
V	17	L	359.6613125	0.314954155	3.30E-04	8.76E-04	1	V17L	missense
V	17	M	891.0415451	0.288472858	4.30E-09	1.40E-08	1	V17M	missense
R	18	G	737.7969612	-1.775171905	7.86E-104	2.43E-102	1	R18G	missense
R	18	K	657.7438324	0.228003831	3.25E-05	9.09E-05	1	R18K	missense
R	18	M	439.1707944	-1.552039493	6.74E-102	1.82E-100	1	R18M	missense
R	18	S	550.2318504	-1.111425382	1.86E-108	6.72E-107	1	R18S	missense
R	18	T	72.55954659	-1.294118846	2.51E-34	1.21E-33	1	R18T	missense
R	18	W	474.8587518	-2.761902095	3.80E-109	1.64E-107	1	R18W	missense
V	19	A	735.6969452	-1.395015467	1.67E-60	1.13E-59	1	V19A	missense
V	19	E	239.8878607	-3.341819055	1.07E-65	7.63E-65	1	V19E	missense
V	19	G	34.29085246	-3.095136491	3.03E-36	1.49E-35	1	V19G	missense
V	19	L	158.647161	-0.845987103	1.13E-37	5.85E-37	1	V19L	missense
V	19	M	590.5872103	-0.891520222	1.43E-88	1.77E-87	1	V19M	missense
F	20	C	38.67190751	-4.171689799	3.54E-65	2.47E-64	1	F20C	missense
F	20	I	170.4280423	-3.759263286	8.49E-135	6.12E-133	1	F20I	missense
F	20	L	1055.927807	-3.014499532	3.56E-93	7.72E-92	1	F20L	missense
F	20	S	666.2074708	-3.211512876	2.91E-90	4.85E-89	1	F20S	missense
F	20	Y	865.925081	0.573006378	1.09E-28	4.80E-28	1	F20Y	missense
F	20	V	46.82474374	-2.517629858	3.70E-69	2.76E-68	1	F20V	missense
Q	21	R	1796.045259	0.097804825	5.56E-04	0.001468734	1	Q21R	missense
Q	21	H	459.6983445	-0.363393127	1.31E-13	4.77E-13	1	Q21H	missense
Q	21	L	751.9766425	-0.623494874	1.70E-31	7.82E-31	1	Q21L	missense
Q	21	K	175.0386948	0.543174007	2.59E-07	7.64E-07	1	Q21K	missense
Q	21	P	57.90836951	-2.695619747	1.26E-67	9.23E-67	1	Q21P	missense
Q	22	R	1056.090463	-0.957702826	4.87E-134	3.01E-132	1	Q22R	missense
Q	22	H	827.0302854	-0.384569948	6.62E-30	2.99E-29	1	Q22H	missense
Q	22	L	911.7416968	-0.934063206	4.59E-97	1.10E-95	1	Q22L	missense
Q	22	K	264.7690598	-0.548569704	8.17E-23	3.37E-22	1	Q22K	missense
Q	22	P	80.62631311	-2.791435524	1.02E-106	3.39E-105	1	Q22P	missense
V	23	A	955.6515239	-1.405073025	3.82E-282	1.66E-279	1	V23A	missense
V	23	E	400.0360556	-2.196682308	1.85E-146	2.67E-144	1	V23E	missense
V	23	G	45.77673929	-3.361567521	1.28E-86	1.09E-85	1	V23G	missense
V	23	L	106.5538413	-0.572091447	3.95E-13	1.40E-12	1	V23L	missense
V	23	M	362.4141288	-1.326478519	1.14E-23	4.82E-23	1	V23M	missense
A	24	E	121.8935164	-1.32918879	1.95E-41	1.06E-40	1	A24E	missense
A	24	G	47.11875997	-1.295585241	4.92E-18	1.90E-17	1	A24G	missense
A	24	P	43.16007313	-2.284353039	6.66E-48	3.90E-47	1	A24P	missense
A	24	S	202.2416731	-0.285254297	6.62E-07	1.94E-06	1	A24S	missense
A	24	T	616.0768431	-0.281072483	6.61E-08	1.99E-07	1	A24T	missense
A	24	V	1776.067402	0.392900383	2.48E-48	1.51E-47	1	A24V	missense
Q	25	H	726.8651517	0.115875615	0.002374687	0.005978135	1	Q25H	missense
Q	25	L	1087.715433	0.370402804	5.14E-36	2.50E-35	1	Q25L	missense
Q	25	K	123.7601598	0.263332458	0.001663951	0.004263258	1	Q25K	missense
Q	25	P	76.51250207	-1.736704535	4.48E-48	2.70E-47	1	Q25P	missense
A	26	D	231.4366966	0.376756134	6.19E-09	1.99E-08	1	A26D	missense
A	26	P	60.07858657	-1.663911377	1.60E-39	8.33E-39	1	A26P	missense
A	26	V	561.1229539	-0.153503146	0.001058958	0.002750888	1	A26V	missense
S	27	A	98.15531991	0.312960189	0.011379292	0.027072711	1	S27A	missense
S	27	F	603.774426	-0.212910935	0.004887529	0.012024432	1	S27F	missense
S	27	P	827.0395383	-2.120250703	1.24E-50	7.70E-50	1	S27P	missense
S	27	T	632.3793779	-0.178005369	0.001982449	0.005049413	1	S27T	missense
S	27	Y	271.8739422	0.518743273	2.31E-19	9.10E-19	1	S27Y	missense
K	28	R	1299.166673	0.155709089	1.68E-04	4.53E-04	1	K28R	missense
K	28	N	300.5338488	0.311411988	8.49E-08	2.53E-07	1	K28N	missense
K	28	E	2433.979336	0.269480347	2.24E-11	7.50E-11	1	K28E	missense
K	28	Q	168.1028552	0.525539409	6.45E-15	2.41E-14	1	K28Q	missense
D	29	A	35.7426227	-0.498623534	0.002785408	0.00709013	2	D29A	missense
D	29	N	456.7617106	0.392633181	6.78E-21	2.60E-20	2	D29N	missense
D	29	E	152.1906474	0.810017163	5.95E-12	1.96E-11	2	D29E	missense
D	29	G	1189.085554	0.241519848	3.49E-09	1.08E-08	2	D29G	missense
D	29	Y	128.0820635	-0.451709566	8.52E-05	2.31E-04	2	D29Y	missense
D	29	V	293.3117151	-1.816415903	4.86E-54	2.79E-53	2	D29V	missense
R	30	C	1885.800403	0.431383584	7.75E-15	2.71E-14	2	R30C	missense
R	30	G	44.63236855	0.519849288	1.75E-05	4.98E-05	2	R30G	missense
R	30	H	2087.058232	0.813969383	1.19E-30	5.11E-30	2	R30H	missense
R	30	P	74.17180249	-1.336651681	1.18E-21	4.60E-21	2	R30P	missense
R	30	S	844.4210418	0.99591851	9.14E-54	5.18E-53	2	R30S	missense
N	31	D	736.4166407	-1.525799369	3.09E-86	2.66E-85	2	N31D	missense
N	31	H	24.76179901	-3.430990092	2.09E-40	9.95E-40	2	N31H	missense
N	31	I	230.0629601	-3.470475079	7.25E-89	6.77E-88	2	N31I	missense
N	31	K	58.91515058	-1.809614539	6.58E-28	2.73E-27	2	N31K	missense
N	31	S	611.8364917	-1.512537395	1.89E-39	8.82E-39	2	N31S	missense
N	31	T	33.38558563	-1.925181424	3.03E-22	1.19E-21	2	N31T	missense
N	31	Y	253.1371012	-3.60934856	9.78E-70	6.95E-69	2	N31Y	missense
V	32	A	1115.817579	-0.799677601	1.09E-59	6.91E-59	2	V32A	missense
V	32	E	287.9818664	-2.308168959	7.67E-63	5.05E-62	2	V32E	missense
V	32	G	53.91838809	-2.881669968	2.84E-76	2.16E-75	2	V32G	missense
V	32	L	388.092452	1.040338151	4.62E-122	4.81E-121	2	V32L	missense
V	32	M	934.3573008	0.144671766	0.016008956	0.038353008	2	V32M	missense
V	33	A	1976.890358	0.926801015	1.66E-41	8.15E-41	2	V33A	missense
V	33	D	90.0539765	-3.219850724	1.01E-40	4.88E-40	2	V33D	missense
V	33	I	623.5907795	0.241851591	3.08E-05	8.51E-05	2	V33I	missense
V	33	F	124.5552626	-0.692871242	3.52E-14	1.21E-13	2	V33F	missense
F	34	C	47.78776693	-0.487760761	2.35E-05	6.61E-05	2	F34C	missense
F	34	I	565.245695	0.357213147	1.89E-12	6.32E-12	2	F34I	missense
F	34	S	762.2440365	-1.377138134	4.98E-131	5.44E-130	2	F34S	missense
F	34	Y	226.639432	-1.626293598	5.53E-101	5.39E-100	2	F34Y	missense
F	34	V	211.8063784	0.585140264	1.24E-17	4.48E-17	2	F34V	missense
S	35	A	84.37442726	-0.315978791	0.006370446	0.016033481	2	S35A	missense
S	35	L	266.227866	-2.400658979	4.33E-83	3.47E-82	2	S35L	missense
S	35	P	740.0769577	-3.202136867	2.63E-57	1.55E-56	2	S35P	missense
S	35	T	399.3933909	-2.000082168	5.71E-172	1.07E-170	2	S35T	missense
P	36	R	26.22884712	-2.198392062	5.84E-26	2.38E-25	2	P36R	missense
P	36	H	242.9377559	-2.974996129	3.88E-116	3.95E-115	2	P36H	missense
P	36	L	395.1195974	-1.945456125	1.46E-87	1.33E-86	2	P36L	missense
P	36	S	1080.175179	-0.257644139	0.012047684	0.029493783	2	P36S	missense
Y	37	N	251.895382	-1.999480721	1.26E-201	2.81E-199	2	Y37N	missense
Y	37	D	33.64195159	-2.429417094	1.25E-38	5.77E-38	2	Y37D	missense
Y	37	C	625.8589407	-1.138974604	1.07E-67	7.35E-67	2	Y37C	missense
Y	37	H	554.6049971	-0.926436697	4.40E-43	2.21E-42	2	Y37H	missense
Y	37	F	935.9158013	1.06068434	6.90E-84	5.62E-83	2	Y37F	missense
Y	37	S	32.52371867	-0.679385118	2.48E-05	6.91E-05	2	Y37S	missense
G	38	A	58.47652068	-0.656234666	2.92E-07	8.54E-07	2	G38A	missense
G	38	R	263.5702815	-2.840469109	2.67E-87	2.39E-86	2	G38R	missense
G	38	E	318.059171	-2.914619983	2.28E-111	2.27E-110	2	G38E	missense
G	38	W	111.1262121	-1.743064363	3.60E-33	1.60E-32	2	G38W	missense
G	38	V	328.4388204	-2.625745059	5.57E-86	4.71E-85	2	G38V	missense
V	39	A	1589.381304	0.38577475	1.36E-29	5.68E-29	2	V39A	missense
V	39	E	242.6388773	-3.253480095	3.86E-40	1.82E-39	2	V39E	missense
V	39	G	84.04959926	-2.272501984	2.43E-84	2.02E-83	2	V39G	missense
V	39	M	588.0263588	-0.573901989	8.52E-19	3.10E-18	2	V39M	missense
A	40	P	40.6438363	-1.471358487	2.94E-15	1.04E-14	2	A40P	missense
A	40	S	291.0905876	0.652907562	2.11E-17	7.57E-17	2	A40S	missense
A	40	T	1084.678766	0.369264797	1.31E-22	5.19E-22	2	A40T	missense
S	41	A	132.4455661	0.241256856	0.009850399	0.024381098	2	S41A	missense
S	41	P	804.9286653	-1.772644208	8.00E-30	3.38E-29	2	S41P	missense
S	41	T	1300.610204	0.654297468	1.85E-32	8.12E-32	2	S41T	missense
S	41	W	108.3245683	0.915158718	4.98E-07	1.45E-06	2	S41W	missense
V	42	A	2426.986478	0.974881783	3.11E-77	2.40E-76	2	V42A	missense
V	42	E	311.9126302	-2.213417052	8.00E-74	5.97E-73	2	V42E	missense
V	42	G	53.06012782	-1.045680721	2.69E-15	9.57E-15	2	V42G	missense
V	42	L	455.7397474	1.323952194	5.39E-90	5.14E-89	2	V42L	missense
V	42	M	1559.616813	0.862930268	2.12E-41	1.03E-40	2	V42M	missense
L	43	M	1307.554109	1.391431799	2.41E-146	2.69E-145	2	L43M	missense
L	43	F	463.6409622	-0.7773732	2.42E-64	1.62E-63	2	L43F	missense
L	43	S	1410.055155	-0.335343725	1.01E-10	3.24E-10	2	L43S	missense
L	43	W	68.76191395	-1.982703478	2.03E-62	1.31E-61	2	L43W	missense
L	43	V	121.4347145	0.391013389	0.012344116	0.030055238	2	L43V	missense
A	44	D	244.9614434	-0.761486815	2.51E-07	7.40E-07	2	A44D	missense
A	44	P	111.2928489	-1.67083989	4.79E-42	2.38E-41	2	A44P	missense
A	44	S	680.3099287	0.934685204	1.39E-58	8.39E-58	2	A44S	missense
A	44	T	1411.141571	0.303674945	9.96E-13	3.38E-12	2	A44T	missense
A	44	V	1785.482239	0.169919675	0.008238403	0.02061902	2	A44V	missense
M	45	I	973.7785527	-0.228115231	1.20E-11	3.91E-11	2	M45I	missense
M	45	L	633.5803796	-0.094038582	0.015345203	0.03696049	2	M45L	missense
M	45	K	4461.999251	1.365855748	4.25E-59	2.65E-58	2	M45K	missense
M	45	T	1385.914415	-0.13587509	1.30E-04	3.49E-04	2	M45T	missense
M	45	V	995.5845348	-0.455089882	6.22E-12	2.03E-11	2	M45V	missense
L	46	R	31.47881385	-4.007261707	2.04E-45	1.04E-44	2	L46R	missense
L	46	H	330.5399215	-2.249747661	1.90E-65	1.29E-64	2	L46H	missense
L	46	I	328.4173973	0.426051682	9.64E-09	2.94E-08	2	L46I	missense
L	46	F	478.9628982	-0.923581787	1.30E-50	7.19E-50	2	L46F	missense
L	46	P	713.4914314	-2.698166182	7.53E-59	4.62E-58	2	L46P	missense
L	46	V	118.706782	0.708264846	1.48E-19	5.48E-19	2	L46V	missense
Q	47	R	768.9750533	-1.87501209	7.01E-56	4.08E-55	2	Q47R	missense
Q	47	E	36.79890171	-0.388648667	0.011420563	0.028112156	2	Q47E	missense
Q	47	H	393.7499062	-0.668963858	3.70E-20	1.39E-19	2	Q47H	missense
Q	47	L	786.1027992	-1.227351937	4.30E-155	5.21E-154	2	Q47L	missense
Q	47	K	218.7571413	-1.770848335	4.50E-49	2.40E-48	2	Q47K	missense
Q	47	P	88.74823164	-1.886642431	5.99E-30	2.56E-29	2	Q47P	missense
L	48	R	159.989265	-0.484373366	5.91E-10	1.86E-09	2	L48R	missense
L	48	M	564.2412383	1.013462187	2.22E-77	1.74E-76	2	L48M	missense
L	48	P	2627.350396	0.29914353	7.42E-05	2.03E-04	2	L48P	missense
L	48	V	192.298876	1.400940768	1.98E-58	1.18E-57	2	L48V	missense
T	49	A	3053.940106	1.491780216	1.21E-86	1.06E-85	2	T49A	missense
T	49	R	42.10414648	-1.663201476	4.41E-26	1.81E-25	2	T49R	missense
T	49	I	792.9275862	0.831942255	1.59E-49	8.71E-49	2	T49I	missense
T	49	P	92.77331535	-0.434699629	1.12E-06	3.23E-06	2	T49P	missense
T	49	S	894.1121364	0.324960734	1.18E-07	3.51E-07	2	T49S	missense
T	50	A	2826.061574	1.405423324	2.51E-70	1.81E-69	2	T50A	missense
T	50	R	64.20605452	-3.18044506	2.88E-51	1.61E-50	2	T50R	missense
T	50	I	324.053458	-1.155781552	1.90E-71	1.40E-70	2	T50I	missense
T	50	K	60.34141414	-1.835787113	5.19E-21	2.00E-20	2	T50K	missense
T	50	P	77.05788759	-2.332630248	1.92E-33	8.61E-33	2	T50P	missense
T	50	S	2053.787603	0.949531935	4.03E-48	2.13E-47	2	T50S	missense
G	51	A	70.35988949	1.40491845	5.68E-20	2.12E-19	2	G51A	missense
G	51	R	1043.099531	0.627458852	1.93E-35	8.80E-35	2	G51R	missense
G	51	E	465.1238887	-0.263183521	1.48E-11	4.79E-11	2	G51E	missense
G	51	V	196.5941896	-0.406196758	4.44E-09	1.36E-08	2	G51V	missense
G	52	A	20.08571918	0.746884035	0.001675469	0.004313852	2	G52A	missense
G	52	R	528.4924287	-0.382243026	1.35E-14	4.70E-14	2	G52R	missense
G	52	E	250.39281	-0.284657152	3.59E-04	9.53E-04	2	G52E	missense
G	52	V	121.5581935	-0.537598042	1.92E-06	5.52E-06	2	G52V	missense
E	53	A	127.5326852	0.910514182	1.76E-20	6.69E-20	2	E53A	missense
E	53	D	569.5567161	0.632002352	9.06E-46	4.67E-45	2	E53D	missense
E	53	Q	25.11693186	1.397640509	4.47E-12	1.48E-11	2	E53Q	missense
E	53	G	1580.972292	0.282719611	1.43E-08	4.31E-08	2	E53G	missense
E	53	K	458.5120046	1.142225086	2.38E-68	1.66E-67	2	E53K	missense
E	53	V	576.6215351	0.624732417	1.24E-34	5.63E-34	2	E53V	missense
T	54	A	966.5314382	-0.69055545	7.60E-14	2.60E-13	2	T54A	missense
T	54	N	46.86701292	-0.481791136	1.39E-04	3.70E-04	2	T54N	missense
T	54	I	281.6678226	-1.015208611	3.38E-49	1.83E-48	2	T54I	missense
T	54	P	35.91862359	-1.224623081	1.53E-12	5.15E-12	2	T54P	missense
Q	55	R	2958.242727	1.413226099	1.80E-154	2.13E-153	2	Q55R	missense
Q	55	H	423.3578694	0.231629644	1.82E-05	5.17E-05	2	Q55H	missense
Q	55	L	1694.700234	1.252531071	1.27E-189	1.43E-187	2	Q55L	missense
Q	55	K	309.5720647	0.900374153	1.17E-23	4.70E-23	2	Q55K	missense
Q	55	P	64.08434237	-2.85921864	2.77E-60	1.77E-59	2	Q55P	missense
Q	56	R	2865.18094	1.48388076	5.66E-281	2.53E-278	2	Q56R	missense
Q	56	E	143.4466398	0.995436922	4.08E-10	1.30E-09	2	Q56E	missense
Q	56	H	938.0136703	1.158142844	7.59E-156	9.44E-155	2	Q56H	missense
Q	56	L	798.9157354	0.356326089	1.42E-08	4.31E-08	2	Q56L	missense
Q	56	K	356.7447517	1.51101281	6.52E-172	1.17E-170	2	Q56K	missense
Q	56	P	63.55004005	-1.326362445	1.01E-31	4.38E-31	2	Q56P	missense
Q	57	R	1013.557137	-0.99951126	4.89E-58	3.42E-57	3	Q57R	missense
Q	57	E	28.13286767	-1.041074436	2.42E-10	7.64E-10	3	Q57E	missense
Q	57	H	312.5524226	-0.965010728	4.45E-23	1.88E-22	3	Q57H	missense
Q	57	L	673.2055398	-1.71107286	1.02E-37	5.17E-37	3	Q57L	missense
Q	57	K	88.37860433	-0.697687825	1.93E-11	6.33E-11	3	Q57K	missense
Q	57	P	60.41199265	-2.767729248	1.38E-45	8.17E-45	3	Q57P	missense
I	58	N	253.3791222	-1.872852921	2.27E-62	1.73E-61	3	I58N	missense
I	58	L	71.56098282	0.263044518	0.016619479	0.038991855	3	I58L	missense
I	58	F	236.0075219	-1.759332864	1.91E-63	1.48E-62	3	I58F	missense
I	58	S	43.55232758	-1.990728539	5.23E-39	2.72E-38	3	I58S	missense
I	58	T	850.4009036	-1.490992629	7.01E-53	4.68E-52	3	I58T	missense
I	58	V	825.2195225	-0.31233889	2.33E-09	7.12E-09	3	I58V	missense
Q	59	R	1641.604163	-0.599788686	8.09E-39	4.16E-38	3	Q59R	missense
Q	59	H	926.9660716	-0.208458296	2.53E-06	7.35E-06	3	Q59H	missense
Q	59	L	692.8898247	-0.665628869	2.12E-58	1.51E-57	3	Q59L	missense
Q	59	P	59.20498076	-2.700356481	4.39E-65	3.47E-64	3	Q59P	missense
A	60	E	431.0433415	0.835487377	1.69E-21	7.01E-21	3	A60E	missense
A	60	P	24.52594922	-1.619356762	1.71E-14	6.04E-14	3	A60P	missense
A	60	S	351.5302051	0.749067645	9.63E-21	3.84E-20	3	A60S	missense
A	60	T	921.2884812	0.733486666	1.33E-52	8.75E-52	3	A60T	missense
A	60	V	734.1482725	-0.137699196	0.009924691	0.023822502	3	A60V	missense
A	61	D	147.5890014	-1.907155996	1.55E-47	9.60E-47	3	A61D	missense
A	61	G	46.99468922	-0.377100294	0.006009924	0.015007237	3	A61G	missense
A	61	P	58.51962557	-1.511691056	2.82E-29	1.34E-28	3	A61P	missense
A	61	T	611.5074989	-0.651922031	9.95E-20	3.83E-19	3	A61T	missense
A	61	V	526.2370145	-0.226376338	2.59E-07	7.58E-07	3	A61V	missense
M	62	R	57.18373821	-4.146208413	1.09E-73	9.51E-73	3	M62R	missense
M	62	I	628.0070838	-1.166631408	1.44E-157	8.80E-156	3	M62I	missense
M	62	L	751.547201	-0.514836868	4.49E-29	2.11E-28	3	M62L	missense
M	62	K	296.7800258	-3.277952252	6.10E-61	4.41E-60	3	M62K	missense
M	62	T	907.7137234	-1.156259617	1.42E-108	1.55E-107	3	M62T	missense
M	62	V	699.8000048	-1.320313059	4.27E-104	4.56E-103	3	M62V	missense
G	63	A	35.95224115	-0.870951988	5.90E-05	1.66E-04	3	G63A	missense
G	63	R	769.2331916	-0.083371648	0.020793112	0.047479458	3	G63R	missense
G	63	E	320.3690997	-1.208422476	2.46E-83	2.28E-82	3	G63E	missense
G	63	V	169.9676346	-1.843854436	1.17E-72	9.97E-72	3	G63V	missense
F	64	C	47.13365395	-1.725690561	4.07E-32	1.95E-31	3	F64C	missense
F	64	I	329.7739247	-0.538581497	9.69E-19	3.60E-18	3	F64I	missense
F	64	L	1447.043215	-0.411715479	9.54E-28	4.29E-27	3	F64L	missense
F	64	S	813.973672	-1.750667529	1.66E-77	1.51E-76	3	F64S	missense
F	64	Y	664.6777201	-0.150924833	0.009930692	0.023822502	3	F64Y	missense
F	64	V	68.28220892	-1.176625888	2.02E-25	8.81E-25	3	F64V	missense
K	65	R	2404.824329	0.439171017	1.89E-40	1.02E-39	3	K65R	missense
K	65	N	436.423168	0.706069867	5.50E-40	2.93E-39	3	K65N	missense
K	65	E	1602.071072	-0.53597705	4.65E-12	1.54E-11	3	K65E	missense
K	65	Q	94.55534991	-0.492827838	1.96E-08	5.91E-08	3	K65Q	missense
K	65	M	748.3096082	-0.918537173	2.90E-93	2.81E-92	3	K65M	missense
K	65	T	90.72770171	-0.447246135	4.30E-06	1.24E-05	3	K65T	missense
I	66	N	316.813122	-1.267632195	8.22E-54	5.57E-53	3	I66N	missense
I	66	F	505.7847369	-0.662352882	1.68E-52	1.08E-51	3	I66F	missense
I	66	V	1413.554403	0.550712492	5.65E-46	3.40E-45	3	I66V	missense
D	67	N	502.5294605	0.276702342	4.48E-11	1.44E-10	3	D67N	missense
D	67	E	1160.346767	0.858322861	1.67E-129	7.92E-128	3	D67E	missense
D	67	G	1759.019508	0.138256309	1.15E-04	3.16E-04	3	D67G	missense
D	67	Y	272.3767966	-0.282158426	1.63E-05	4.61E-05	3	D67Y	missense
D	67	V	594.4220127	-0.437152639	4.99E-18	1.82E-17	3	D67V	missense
D	68	A	92.34882064	-0.208904102	0.017850772	0.041425433	3	D68A	missense
D	68	N	496.8534438	-0.52491264	1.13E-33	5.61E-33	3	D68N	missense
D	68	E	325.7482051	0.524400021	1.13E-13	3.92E-13	3	D68E	missense
D	68	G	1270.525272	-0.446032462	7.52E-43	4.17E-42	3	D68G	missense
D	68	Y	86.11581197	-1.005949582	3.26E-19	1.24E-18	3	D68Y	missense
D	68	V	610.0997672	-1.05698113	5.45E-116	8.02E-115	3	D68V	missense
K	69	R	1529.146055	0.344499988	2.32E-23	9.90E-23	3	K69R	missense
K	69	N	727.2826668	0.463121828	3.48E-13	1.20E-12	3	K69N	missense
K	69	E	2953.006765	1.030673118	5.81E-104	6.05E-103	3	K69E	missense
K	69	Q	180.7197788	0.515252322	2.82E-12	9.41E-12	3	K69Q	missense
K	69	M	1003.113753	0.350299231	3.82E-21	1.57E-20	3	K69M	missense
K	69	T	176.0828229	0.48825616	1.67E-09	5.18E-09	3	K69T	missense
G	70	D	1170.189761	0.501689167	2.33E-43	1.31E-42	3	G70D	missense
G	70	C	478.0576961	0.220881374	8.59E-05	2.38E-04	3	G70C	missense
G	70	V	322.0148392	0.209097018	0.002292148	0.006041648	3	G70V	missense
M	71	R	102.9059461	-1.077950582	5.87E-20	2.28E-19	3	M71R	missense
M	71	I	1630.390796	0.800468032	5.37E-71	4.50E-70	3	M71I	missense
M	71	K	601.7081843	-0.986773692	6.00E-71	4.93E-70	3	M71K	missense
M	71	T	2810.74203	0.447361846	5.85E-19	2.19E-18	3	M71T	missense
M	71	V	3554.079005	1.06779109	1.15E-100	1.14E-99	3	M71V	missense
A	72	D	207.0770444	-0.607790596	1.53E-15	5.50E-15	3	A72D	missense
A	72	G	125.4976352	0.298775956	0.008506803	0.020875891	3	A72G	missense
A	72	P	136.5398541	-0.591857789	8.23E-11	2.62E-10	3	A72P	missense
A	72	S	203.2819797	-0.497000709	2.55E-04	6.88E-04	3	A72S	missense
A	72	T	829.0659116	-0.484696347	3.55E-18	1.31E-17	3	A72T	missense
A	72	V	938.71228	-0.137318933	0.005073663	0.012743848	3	A72V	missense
P	73	A	32.52780291	0.49432841	0.004685708	0.011839038	3	P73A	missense
P	73	R	54.02721099	0.492337076	6.71E-05	1.87E-04	3	P73R	missense
P	73	H	445.0434512	0.407302391	1.65E-07	4.87E-07	3	P73H	missense
P	73	L	831.8735707	0.222149424	7.06E-06	2.02E-05	3	P73L	missense
P	73	S	946.7860978	0.540982148	2.63E-34	1.32E-33	3	P73S	missense
P	73	T	263.5074874	0.251626007	0.002371156	0.006211557	3	P73T	missense
A	74	D	140.8504355	-0.279442735	1.11E-04	3.07E-04	3	A74D	missense
A	74	G	65.90423292	0.6469598	1.14E-08	3.44E-08	3	A74G	missense
A	74	P	114.1008317	-0.773653148	1.15E-12	3.90E-12	3	A74P	missense
A	74	T	1236.494001	-0.303639726	1.82E-12	6.12E-12	3	A74T	missense
A	74	V	611.4468773	-0.572427231	2.08E-44	1.20E-43	3	A74V	missense
L	75	R	36.67543836	-1.685460974	3.64E-27	1.62E-26	3	L75R	missense
L	75	H	405.3342953	-1.161304448	9.47E-67	7.63E-66	3	L75H	missense
L	75	F	637.9933848	0.822967957	6.81E-50	4.34E-49	3	L75F	missense
L	75	P	888.8660313	-1.579845826	1.90E-77	1.69E-76	3	L75P	missense
R	76	Q	1634.020584	0.643048818	1.83E-61	1.35E-60	3	R76Q	missense
R	76	G	85.51371661	0.269938869	0.003405015	0.008758683	3	R76G	missense
R	76	L	1470.709829	0.484852636	4.01E-21	1.63E-20	3	R76L	missense
R	76	P	122.4950524	-0.606859736	4.55E-13	1.55E-12	3	R76P	missense
H	77	R	1351.391284	0.291622041	1.59E-09	4.96E-09	3	H77R	missense
H	77	N	174.9563304	0.565308559	3.12E-11	1.01E-10	3	H77N	missense
H	77	D	133.5452874	0.937546399	2.13E-28	9.68E-28	3	H77D	missense
H	77	Q	696.4758544	0.666264356	5.89E-49	3.70E-48	3	H77Q	missense
H	77	L	794.8865406	0.45027803	1.51E-32	7.32E-32	3	H77L	missense
H	77	P	41.73455408	-1.038496185	1.40E-14	4.99E-14	3	H77P	missense
H	77	Y	1361.039445	0.46337852	1.21E-33	5.93E-33	3	H77Y	missense
L	78	R	117.8652677	-1.976788205	1.54E-101	1.56E-100	3	L78R	missense
L	78	Q	788.1887002	-1.399516285	2.13E-92	2.02E-91	3	L78Q	missense
L	78	M	386.3213386	-0.183966841	0.001974701	0.005237251	3	L78M	missense
L	78	P	1747.28447	-1.340204063	1.04E-245	4.43E-243	3	L78P	missense
Y	79	N	1443.205006	0.927068707	8.14E-43	4.46E-42	3	Y79N	missense
Y	79	D	141.3245862	0.576153416	2.11E-09	6.48E-09	3	Y79D	missense
Y	79	C	1556.032662	-0.157922964	6.12E-04	0.001633447	3	Y79C	missense
Y	79	H	2429.460153	1.10860868	3.76E-159	2.68E-157	3	Y79H	missense
Y	79	F	1087.938635	0.232229946	3.25E-08	9.64E-08	3	Y79F	missense
Y	79	S	155.8726941	0.969796704	9.73E-29	4.52E-28	3	Y79S	missense
K	80	R	1411.340406	0.417551601	7.74E-22	3.24E-21	3	K80R	missense
K	80	N	588.1991454	0.877394735	3.64E-45	2.13E-44	3	K80N	missense
K	80	E	3061.223037	0.990992431	6.75E-148	3.60E-146	3	K80E	missense
K	80	Q	203.7701081	0.845266256	1.45E-28	6.64E-28	3	K80Q	missense
K	80	M	1460.372204	0.538926882	3.82E-46	2.33E-45	3	K80M	missense
K	80	T	176.8389357	0.709851721	2.15E-23	9.27E-23	3	K80T	missense
E	81	A	61.86986595	-0.40750801	0.00387041	0.009837291	3	E81A	missense
E	81	D	461.6472306	0.412319819	2.27E-14	7.96E-14	3	E81D	missense
E	81	G	1256.862158	-0.787342558	3.68E-110	4.13E-109	3	E81G	missense
E	81	K	447.757818	-0.918050252	3.98E-57	2.74E-56	3	E81K	missense
E	81	V	549.9281157	-0.421071086	2.29E-20	8.98E-20	3	E81V	missense
L	82	R	71.82969873	-1.680713574	7.08E-44	4.03E-43	3	L82R	missense
L	82	H	562.1547865	-1.596375472	2.74E-186	2.93E-184	3	L82H	missense
L	82	I	633.8173767	1.035933337	3.94E-62	2.95E-61	3	L82I	missense
L	82	P	1265.484085	-1.649995295	1.30E-167	1.11E-165	3	L82P	missense
L	82	V	105.2123678	0.696267817	2.39E-08	7.13E-08	3	L82V	missense
M	83	I	1217.990922	0.4566353	4.32E-21	1.74E-20	3	M83I	missense
M	83	L	829.4379007	0.293755349	2.30E-11	7.50E-11	3	M83L	missense
M	83	K	937.8551677	0.395095423	1.38E-20	5.46E-20	3	M83K	missense
M	83	T	1472.201143	0.144993096	0.016531401	0.038991855	3	M83T	missense
M	83	V	1612.128867	0.157610366	3.68E-04	9.87E-04	3	M83V	missense
G	84	R	1450.316201	-0.360311807	2.59E-12	9.77E-12	4	G84R	missense
G	84	E	1749.183787	0.199476901	0.00308065	0.007937972	4	G84E	missense
G	84	W	762.4029099	-0.527895365	1.42E-11	5.26E-11	4	G84W	missense
G	84	V	1320.149621	-0.242309741	9.67E-05	2.79E-04	4	G84V	missense
P	85	A	221.0503686	0.480240073	5.84E-10	2.00E-09	4	P85A	missense
P	85	S	2031.557471	0.655436096	1.66E-21	7.49E-21	4	P85S	missense
P	85	T	590.1282127	0.53334019	7.59E-13	2.93E-12	4	P85T	missense
W	86	R	2432.122995	-0.137888799	0.001096713	0.002930266	4	W86R	missense
W	86	C	620.615229	0.483156038	2.33E-15	9.63E-15	4	W86C	missense
W	86	G	136.2794659	0.542422639	2.39E-12	9.09E-12	4	W86G	missense
W	86	L	1913.503109	0.881795494	2.89E-31	1.50E-30	4	W86L	missense
W	86	S	78.47684925	0.372950736	0.002017211	0.005281621	4	W86S	missense
N	87	D	2313.722366	-0.256791027	3.68E-08	1.17E-07	4	N87D	missense
N	87	I	1048.729175	-0.644680126	9.91E-18	4.23E-17	4	N87I	missense
N	87	K	145.9852541	-0.491316712	5.26E-08	1.66E-07	4	N87K	missense
N	87	Y	1158.875958	-0.297206079	2.38E-06	7.20E-06	4	N87Y	missense
K	88	R	2717.917397	0.572853848	1.59E-45	1.94E-44	4	K88R	missense
K	88	N	1829.697238	0.53721333	6.02E-25	2.90E-24	4	K88N	missense
K	88	E	3329.776065	0.473379461	6.12E-12	2.28E-11	4	K88E	missense
K	88	Q	245.3518943	0.53228535	1.10E-08	3.64E-08	4	K88Q	missense
K	88	M	1307.178257	0.271516808	1.33E-10	4.75E-10	4	K88M	missense
K	88	T	187.3389772	0.287237871	7.77E-04	0.002138834	4	K88T	missense
D	89	N	881.0571016	0.901558269	3.30E-78	8.93E-77	4	D89N	missense
D	89	E	1102.937621	0.306366621	2.29E-14	9.36E-14	4	D89E	missense
D	89	G	1571.001402	0.301964785	6.33E-13	2.46E-12	4	D89G	missense
D	89	H	97.41293402	0.474017948	3.32E-04	9.29E-04	4	D89H	missense
D	89	V	694.2143816	0.203826019	1.66E-05	4.95E-05	4	D89V	missense
E	90	D	280.257774	-0.371338326	7.49E-11	2.70E-10	4	E90D	missense
E	90	G	2281.496809	0.220586867	1.17E-04	3.34E-04	4	E90G	missense
E	90	K	434.1223757	-0.672472109	7.94E-23	3.72E-22	4	E90K	missense
I	91	N	624.4247631	-1.877223304	3.82E-181	1.86E-178	4	I91N	missense
I	91	L	466.601736	1.573592192	8.34E-27	4.10E-26	4	I91L	missense
I	91	M	315.386213	1.228115608	1.07E-18	4.71E-18	4	I91M	missense
I	91	F	5810.9331	1.773283149	4.82E-106	2.61E-104	4	I91F	missense
I	91	S	56.63743275	-1.757031868	3.06E-22	1.40E-21	4	I91S	missense
I	91	T	694.0959144	-1.886753255	2.68E-82	8.15E-81	4	I91T	missense
I	91	V	1278.859231	-0.256386001	7.13E-08	2.24E-07	4	I91V	missense
S	92	R	644.1837243	0.345816441	1.69E-17	7.15E-17	4	S92R	missense
S	92	N	930.0799034	-0.149745135	8.54E-04	0.002323722	4	S92N	missense
S	92	C	1286.290229	0.853031835	6.02E-84	2.10E-82	4	S92C	missense
S	92	G	1772.375548	-0.246089888	4.62E-10	1.61E-09	4	S92G	missense
S	92	I	757.0089184	1.433560826	1.31E-106	7.96E-105	4	S92I	missense
S	92	T	101.524386	0.742219309	2.74E-14	1.11E-13	4	S92T	missense
T	93	A	4334.79754	0.99234653	2.98E-61	5.59E-60	4	T93A	missense
T	93	I	2289.59355	1.17692745	5.68E-77	1.32E-75	4	T93I	missense
T	93	P	52.85809607	-1.731496129	2.59E-39	2.68E-38	4	T93P	missense
T	93	S	1724.411894	0.894039135	2.22E-90	9.82E-89	4	T93S	missense
T	94	A	3253.612905	1.333587	3.69E-173	8.98E-171	4	T94A	missense
T	94	R	57.82866155	-2.053826255	1.82E-58	3.16E-57	4	T94R	missense
T	94	I	1251.960265	0.835512168	1.42E-55	2.09E-54	4	T94I	missense
T	94	K	48.65903388	-1.115617273	1.19E-07	3.72E-07	4	T94K	missense
T	94	P	90.63437975	-2.618329511	1.75E-128	1.71E-126	4	T94P	missense
D	95	A	219.8853366	1.055024282	4.67E-38	3.50E-37	4	D95A	missense
D	95	N	544.0934282	0.459542614	2.75E-17	1.15E-16	4	D95N	missense
D	95	E	778.6228795	1.052669054	1.83E-77	4.45E-76	4	D95E	missense
D	95	G	3327.810906	0.903724207	1.59E-36	9.45E-36	4	D95G	missense
D	95	Y	373.901437	-0.352620389	2.93E-05	8.64E-05	4	D95Y	missense
A	96	E	159.6115504	-0.992783658	1.55E-22	7.20E-22	4	A96E	missense
A	96	G	76.56242541	-0.281240323	0.005726484	0.014375246	4	A96G	missense
A	96	P	80.95324336	-2.434042768	4.26E-85	1.59E-83	4	A96P	missense
A	96	S	210.0037584	-0.936847155	5.66E-25	2.75E-24	4	A96S	missense
A	96	T	945.6636949	-1.01017409	5.45E-104	2.65E-102	4	A96T	missense
I	97	N	165.4108162	-3.612477086	2.21E-35	1.26E-34	4	I97N	missense
I	97	M	13.97211915	-0.905162216	1.77E-04	5.01E-04	4	I97M	missense
I	97	F	433.322773	-1.28864654	2.82E-32	1.51E-31	4	I97F	missense
I	97	S	23.21462518	-3.868731693	8.76E-45	1.04E-43	4	I97S	missense
I	97	T	528.0961318	-2.970879171	7.28E-58	1.18E-56	4	I97T	missense
I	97	V	897.2614358	-0.81549095	2.97E-47	3.70E-46	4	I97V	missense
F	98	C	32.51202027	-4.029658609	3.13E-60	5.64E-59	4	F98C	missense
F	98	I	620.5028506	-0.716223138	3.42E-67	6.67E-66	4	F98I	missense
F	98	L	1228.551826	-2.185599168	1.33E-158	2.16E-156	4	F98L	missense
F	98	S	653.4609405	-3.712371395	4.34E-90	1.76E-88	4	F98S	missense
F	98	Y	431.113587	-1.006954935	4.75E-58	7.98E-57	4	F98Y	missense
F	98	V	90.69898392	-1.743591022	7.66E-42	8.88E-41	4	F98V	missense
V	99	A	1147.716385	-1.609345718	8.25E-149	1.00E-146	4	V99A	missense
V	99	D	252.2016566	-4.105525082	2.06E-47	2.64E-46	4	V99D	missense
V	99	G	39.50249739	-3.157207079	1.17E-33	6.48E-33	4	V99G	missense
V	99	I	1718.538211	0.611866542	3.35E-38	2.63E-37	4	V99I	missense
V	99	F	102.5682957	-1.286577145	9.73E-42	1.10E-40	4	V99F	missense
Q	100	R	1104.116625	-1.195378896	1.44E-57	2.19E-56	4	Q100R	missense
Q	100	E	126.1484175	-0.276515202	0.012727447	0.031304377	4	Q100E	missense
Q	100	H	837.6684496	0.999327406	1.42E-69	3.01E-68	4	Q100H	missense
Q	100	L	637.8793587	-1.661181019	1.30E-74	2.88E-73	4	Q100L	missense
Q	100	K	659.0422065	-0.621737371	5.14E-50	7.16E-49	4	Q100K	missense
Q	100	P	159.3775762	-0.204768379	0.01756523	0.042558542	4	Q100P	missense
R	101	Q	1313.418704	0.550915647	1.14E-28	5.69E-28	4	R101Q	missense
R	101	G	93.5786505	-0.436387716	1.20E-06	3.68E-06	4	R101G	missense
R	101	L	311.7050042	-0.964159593	6.94E-38	4.83E-37	4	R101L	missense
R	101	P	24.0095215	-1.140008635	8.55E-10	2.91E-09	4	R101P	missense
R	101	W	704.7641497	-0.917030976	1.28E-80	3.66E-79	4	R101W	missense
D	102	A	36.94918413	-2.627096654	5.53E-48	7.49E-47	4	D102A	missense
D	102	E	342.4524381	-0.683429214	8.08E-36	4.74E-35	4	D102E	missense
D	102	G	1117.487958	-0.103058506	0.014758284	0.036117008	4	D102G	missense
D	102	H	64.70680201	-0.705331785	1.36E-08	4.48E-08	4	D102H	missense
D	102	Y	207.5893322	-1.968477936	3.10E-33	1.69E-32	4	D102Y	missense
D	102	V	575.1737064	-3.649926896	7.35E-84	2.39E-82	4	D102V	missense
L	103	R	87.86373212	-1.770641397	1.33E-41	1.47E-40	4	L103R	missense
L	103	Q	579.5698831	-1.024573746	1.26E-30	6.42E-30	4	L103Q	missense
L	103	P	947.7313765	-1.381775508	4.73E-31	2.43E-30	4	L103P	missense
L	103	V	20.72821256	0.671166649	2.25E-04	6.34E-04	4	L103V	missense
K	104	R	2479.163496	0.193684613	2.92E-10	1.03E-09	4	K104R	missense
K	104	E	2033.033498	0.109894615	0.00485786	0.012386272	4	K104E	missense
K	104	Q	140.1924001	0.256016745	9.23E-04	0.002483248	4	K104Q	missense
K	104	M	828.466657	-0.577531038	4.57E-29	2.29E-28	4	K104M	missense
L	105	R	82.92400905	-1.226831898	1.14E-20	5.05E-20	4	L105R	missense
L	105	Q	659.7908897	-0.744350832	4.49E-10	1.57E-09	4	L105Q	missense
L	105	M	330.5244762	0.400351573	3.05E-11	1.12E-10	4	L105M	missense
L	105	P	1165.82066	-0.645947684	1.04E-20	4.64E-20	4	L105P	missense
V	106	A	2543.226645	0.556726085	5.76E-35	3.23E-34	4	V106A	missense
V	106	G	58.27783579	-0.46328407	1.31E-04	3.74E-04	4	V106G	missense
V	106	I	810.8838342	-0.249940285	1.85E-06	5.66E-06	4	V106I	missense
V	106	L	95.9298937	-0.492077136	1.92E-06	5.85E-06	4	V106L	missense
V	106	F	86.76528303	-0.520377445	2.10E-09	7.09E-09	4	V106F	missense
Q	107	R	2065.424042	0.227660047	1.37E-08	4.49E-08	4	Q107R	missense
Q	107	E	30.55584325	0.883196934	3.20E-08	1.02E-07	4	Q107E	missense
Q	107	L	687.5122656	-1.056564657	7.83E-58	1.23E-56	4	Q107L	missense
Q	107	K	297.2246319	0.510136194	5.04E-14	2.01E-13	4	Q107K	missense
Q	107	P	271.1237736	0.997487452	1.10E-16	4.60E-16	4	Q107P	missense
G	108	A	85.72608952	-0.557277575	3.29E-09	1.10E-08	4	G108A	missense
G	108	D	933.537689	0.310375959	2.77E-14	1.12E-13	4	G108D	missense
G	108	C	269.1512563	-0.54661503	1.73E-18	7.54E-18	4	G108C	missense
G	108	V	152.3667287	-1.025714231	2.25E-37	1.40E-36	4	G108V	missense
F	109	C	73.11750403	-0.697109022	7.08E-07	2.20E-06	4	F109C	missense
F	109	I	607.471591	-0.563640396	8.12E-32	4.30E-31	4	F109I	missense
F	109	L	1832.562667	-0.670155123	6.59E-48	8.67E-47	4	F109L	missense
F	109	S	1447.234028	-0.471530817	1.88E-08	6.10E-08	4	F109S	missense
F	109	Y	755.7252879	-0.684676026	1.16E-21	5.26E-21	4	F109Y	missense
F	109	V	146.2642727	-0.511963805	4.78E-10	1.65E-09	4	F109V	missense
M	110	A	13.2419283	0.784615601	0.005613344	0.01416424	4	M110A	missense
M	110	R	102.1565791	0.410187155	1.15E-05	3.45E-05	4	M110R	missense
M	110	K	842.8826136	0.678173793	1.09E-35	6.31E-35	4	M110K	missense
M	110	T	2475.132146	0.695267166	1.66E-77	4.26E-76	4	M110T	missense
M	110	V	1904.664778	0.332381086	4.79E-23	2.26E-22	4	M110V	missense
P	111	H	531.5940735	-0.349214298	3.05E-13	1.20E-12	4	P111H	missense
P	111	L	566.383789	-0.84640476	2.22E-67	4.51E-66	4	P111L	missense
P	111	S	877.7433985	-0.133284296	8.19E-04	0.002240675	4	P111S	missense
P	111	T	319.4558939	-0.255671502	5.60E-05	1.64E-04	4	P111T	missense
H	112	R	1843.557909	0.582160043	2.25E-32	1.22E-31	4	H112R	missense
H	112	Q	321.041106	0.534823619	2.84E-13	1.12E-12	4	H112Q	missense
H	112	P	113.0730816	-0.640351537	1.69E-12	6.48E-12	4	H112P	missense
F	113	C	61.34356617	-0.324053197	0.002597952	0.006729801	4	F113C	missense
F	113	I	541.5796792	-0.743181752	4.25E-40	4.60E-39	4	F113I	missense
F	113	L	1389.901454	-0.687201126	3.16E-24	1.51E-23	4	F113L	missense
F	113	S	1090.932411	-0.186516523	0.018026168	0.043459129	4	F113S	missense
F	113	Y	548.4733262	0.268767534	3.06E-08	9.88E-08	4	F113Y	missense
F	113	V	96.82842378	-0.656071371	3.77E-11	1.37E-10	4	F113V	missense
F	114	C	115.8464056	0.506255692	4.17E-09	1.39E-08	4	F114C	missense
F	114	S	2323.158858	0.688006443	2.33E-54	3.34E-53	4	F114S	missense
F	114	Y	1347.448578	0.876512662	5.43E-117	4.41E-115	4	F114Y	missense
R	115	G	2472.30231	0.512095488	5.80E-50	2.88E-49	5	R115G	missense
R	115	K	860.6695294	0.823028103	6.32E-68	7.06E-67	5	R115K	missense
R	115	S	601.8912964	0.942937244	3.12E-62	3.06E-61	5	R115S	missense
R	115	T	185.7134414	0.591760928	8.73E-12	2.61E-11	5	R115T	missense
R	115	W	1449.312063	0.45382795	3.29E-12	9.96E-12	5	R115W	missense
L	116	R	104.602026	-0.681580533	2.39E-11	7.07E-11	5	L116R	missense
L	116	Q	1047.650733	0.672773863	1.24E-33	4.98E-33	5	L116Q	missense
L	116	M	573.8860846	0.885206734	1.29E-37	5.59E-37	5	L116M	missense
L	116	P	980.3683785	-0.270098954	3.34E-04	8.49E-04	5	L116P	missense
L	116	V	215.3761304	0.808158427	1.67E-07	4.71E-07	5	L116V	missense
F	117	C	81.75863576	0.318938047	0.002023321	0.004918072	5	F117C	missense
F	117	I	383.044019	-0.854433044	2.42E-57	2.01E-56	5	F117I	missense
F	117	L	1478.29277	-0.744344714	3.61E-95	5.90E-94	5	F117L	missense
F	117	S	1742.229101	0.249904776	6.46E-09	1.88E-08	5	F117S	missense
F	117	Y	588.3996678	-0.254372287	1.68E-06	4.57E-06	5	F117Y	missense
F	117	V	70.00510871	-0.274980453	0.009266184	0.021360077	5	F117V	missense
R	118	Q	1667.874399	0.917475513	6.66E-52	3.44E-51	5	R118Q	missense
R	118	G	215.3578749	1.468304443	1.19E-54	6.48E-54	5	R118G	missense
R	118	L	730.9161749	-0.642466036	7.99E-33	3.16E-32	5	R118L	missense
R	118	P	123.402982	1.010524118	1.39E-35	5.85E-35	5	R118P	missense
R	118	W	689.6823907	-0.964368879	3.40E-85	4.51E-84	5	R118W	missense
S	119	R	407.6480561	0.958640813	1.90E-45	8.95E-45	5	S119R	missense
S	119	N	1098.57464	0.443242639	4.26E-16	1.44E-15	5	S119N	missense
S	119	C	916.1912588	0.775235023	2.90E-59	2.58E-58	5	S119C	missense
S	119	G	1856.993571	0.540787637	4.33E-35	1.77E-34	5	S119G	missense
S	119	I	295.1887011	0.239736674	1.03E-04	2.62E-04	5	S119I	missense
S	119	T	218.3835664	1.129558777	1.47E-35	6.12E-35	5	S119T	missense
T	120	A	1186.419802	-0.288337729	2.20E-15	7.30E-15	5	T120A	missense
T	120	R	69.59254178	0.573867232	4.14E-07	1.15E-06	5	T120R	missense
T	120	K	166.3198399	0.233607033	0.001722542	0.00422884	5	T120K	missense
T	120	M	861.5002368	-0.743020526	1.47E-61	1.41E-60	5	T120M	missense
T	120	S	963.7702946	0.612661686	5.73E-28	2.15E-27	5	T120S	missense
V	121	A	935.1179024	-1.615139725	2.04E-180	8.35E-179	5	V121A	missense
V	121	D	398.4491674	-3.600776974	1.61E-43	7.44E-43	5	V121D	missense
V	121	G	45.7939693	-2.909547395	2.88E-68	3.29E-67	5	V121G	missense
V	121	I	1038.461262	0.812515982	4.21E-58	3.63E-57	5	V121I	missense
V	121	L	143.1643229	0.581198724	9.35E-09	2.69E-08	5	V121L	missense
V	121	F	135.2398304	-0.235248575	0.003997626	0.009574801	5	V121F	missense
K	122	R	2072.413779	0.429268054	5.80E-23	2.07E-22	5	K122R	missense
K	122	N	395.7330849	0.484995753	8.46E-18	2.88E-17	5	K122N	missense
K	122	E	1469.669022	0.3229738	1.28E-06	3.50E-06	5	K122E	missense
K	122	Q	194.1948498	1.113624282	5.48E-52	2.86E-51	5	K122Q	missense
K	122	M	1151.911322	0.549458279	3.03E-39	1.35E-38	5	K122M	missense
Q	123	R	1499.086147	0.503089197	2.14E-31	8.34E-31	5	Q123R	missense
Q	123	E	120.6144807	0.934061868	7.17E-24	2.59E-23	5	Q123E	missense
Q	123	H	1147.591423	-0.302425696	2.35E-07	6.57E-07	5	Q123H	missense
Q	123	L	1019.278379	0.488572832	6.80E-25	2.47E-24	5	Q123L	missense
Q	123	P	114.7299001	0.459810539	1.17E-07	3.32E-07	5	Q123P	missense
V	124	A	945.6719404	-1.553062582	7.52E-189	3.36E-187	5	V124A	missense
V	124	E	325.4605057	-3.109659801	8.25E-55	4.55E-54	5	V124E	missense
V	124	G	51.87698585	-3.642112103	8.51E-68	9.29E-67	5	V124G	missense
V	124	L	206.6706937	-0.771499311	5.32E-28	2.01E-27	5	V124L	missense
V	124	M	306.0441239	-1.669911387	5.27E-107	9.95E-106	5	V124M	missense
D	125	A	26.5270292	-2.952485271	1.50E-40	6.80E-40	5	D125A	missense
D	125	E	154.1422085	-0.695859777	3.68E-14	1.16E-13	5	D125E	missense
D	125	G	661.3369201	-2.406577628	4.43E-153	1.28E-151	5	D125G	missense
D	125	H	26.85671135	-0.992185212	6.01E-05	1.55E-04	5	D125H	missense
D	125	Y	104.9221503	-1.23558021	5.14E-07	1.42E-06	5	D125Y	missense
D	125	V	165.9412414	-2.95694727	1.29E-86	1.81E-85	5	D125V	missense
F	126	C	67.59806147	-3.661397408	1.19E-46	5.73E-46	5	F126C	missense
F	126	I	224.4675154	-3.243687006	7.06E-60	6.42E-59	5	F126I	missense
F	126	L	912.8257966	-2.496480152	2.47E-175	8.65E-174	5	F126L	missense
F	126	S	619.4874317	-3.157525295	1.45E-60	1.37E-59	5	F126S	missense
F	126	Y	483.3617441	-0.698131163	3.68E-40	1.66E-39	5	F126Y	missense
F	126	V	68.46043887	-3.343954899	2.88E-106	5.24E-105	5	F126V	missense
S	127	A	107.2466	0.514559905	6.07E-07	1.66E-06	5	S127A	missense
S	127	L	508.5828302	0.531847468	8.69E-15	2.81E-14	5	S127L	missense
S	127	P	913.9407033	-1.532582707	1.64E-159	5.03E-158	5	S127P	missense
S	127	T	1404.134529	1.134387041	4.95E-100	8.69E-99	5	S127T	missense
E	128	A	58.58083397	-0.788779327	8.16E-12	2.46E-11	5	E128A	missense
E	128	D	1895.632688	1.26172832	1.31E-90	1.95E-89	5	E128D	missense
E	128	Q	23.00878045	0.775190383	3.09E-05	8.07E-05	5	E128Q	missense
E	128	G	739.7061054	-1.380407866	3.12E-220	2.19E-218	5	E128G	missense
E	128	K	276.6969539	-0.731863003	3.79E-35	1.56E-34	5	E128K	missense
E	128	V	422.9433239	-1.438232293	9.77E-145	2.52E-143	5	E128V	missense
V	129	A	3202.420056	1.199304702	2.17E-92	3.43E-91	5	V129A	missense
V	129	E	1426.196802	1.089098364	2.57E-85	3.50E-84	5	V129E	missense
V	129	G	157.1670103	0.943311467	3.58E-26	1.32E-25	5	V129G	missense
V	129	L	177.9804141	-0.622297918	6.24E-15	2.03E-14	5	V129L	missense
E	130	A	71.48697128	-0.949364973	5.98E-15	1.96E-14	5	E130A	missense
E	130	D	259.4684684	0.628404148	1.76E-18	6.05E-18	5	E130D	missense
E	130	Q	40.83688619	-0.350583203	0.022139415	0.04941115	5	E130Q	missense
E	130	G	1488.135907	-0.792529713	8.40E-46	4.00E-45	5	E130G	missense
E	130	K	295.8705625	-1.330460433	3.96E-64	4.05E-63	5	E130K	missense
E	130	V	621.4962708	-1.270012808	4.93E-175	1.61E-173	5	E130V	missense
R	131	G	1927.502097	0.454401283	2.09E-29	8.01E-29	5	R131G	missense
R	131	K	574.8393481	0.883319966	1.95E-37	8.40E-37	5	R131K	missense
R	131	S	1250.530261	0.997711104	4.98E-70	5.82E-69	5	R131S	missense
R	131	T	17.35992185	0.894949582	3.99E-05	1.04E-04	5	R131T	missense
A	132	D	160.8546381	-2.172180682	1.91E-60	1.77E-59	5	A132D	missense
A	132	G	94.37001256	-1.538421944	6.75E-44	3.16E-43	5	A132G	missense
A	132	P	86.3831518	-1.941613533	4.05E-49	1.99E-48	5	A132P	missense
A	132	S	400.069434	0.445172542	6.81E-14	2.12E-13	5	A132S	missense
A	132	V	649.0446416	-0.710948349	3.97E-54	2.14E-53	5	A132V	missense
R	133	G	1282.688308	-1.460030575	3.93E-250	3.86E-248	5	R133G	missense
R	133	I	153.0333201	-0.723682934	1.42E-13	4.38E-13	5	R133I	missense
R	133	K	317.1107686	-0.497664275	6.10E-14	1.91E-13	5	R133K	missense
R	133	S	451.8775439	-0.196785031	0.001948135	0.004758877	5	R133S	missense
R	133	T	41.93510202	0.634914231	2.54E-06	6.79E-06	5	R133T	missense
F	134	C	112.1477021	0.788548179	6.38E-16	2.15E-15	5	F134C	missense
F	134	I	445.974262	0.239055986	0.00203625	0.004925117	5	F134I	missense
F	134	L	1924.528108	0.390114299	5.69E-29	2.17E-28	5	F134L	missense
F	134	S	1559.780454	0.624017669	1.82E-53	9.73E-53	5	F134S	missense
F	134	Y	961.0064925	0.556465752	8.19E-24	2.93E-23	5	F134Y	missense
I	135	N	541.0196385	-0.832449789	5.71E-43	2.62E-42	5	I135N	missense
I	135	L	96.10579322	0.448524691	2.50E-06	6.70E-06	5	I135L	missense
I	135	F	549.8925811	0.473831429	1.44E-19	4.97E-19	5	I135F	missense
I	135	S	64.9634706	-0.323652288	6.91E-04	0.00173112	5	I135S	missense
I	135	T	1539.24862	0.508307178	1.69E-32	6.65E-32	5	I135T	missense
I	135	V	1757.910511	0.46559782	5.53E-38	2.42E-37	5	I135V	missense
I	136	N	388.4542441	-3.207300926	2.61E-195	1.28E-193	5	I136N	missense
I	136	L	77.93412413	-1.839997276	1.95E-15	6.50E-15	5	I136L	missense
I	136	M	48.30015001	-0.673561313	2.13E-07	5.98E-07	5	I136M	missense
I	136	F	354.1035634	-2.870522953	2.07E-109	4.07E-108	5	I136F	missense
I	136	S	41.23375795	-3.205237975	6.05E-67	6.46E-66	5	I136S	missense
I	136	T	917.5161705	-2.578567898	2.18E-131	5.09E-130	5	I136T	missense
I	136	V	1381.05036	-0.383590046	7.34E-20	2.56E-19	5	I136V	missense
N	137	D	1129.852944	-0.945639644	6.87E-99	1.16E-97	5	N137D	missense
N	137	H	62.59025298	-2.246297644	3.67E-52	1.94E-51	5	N137H	missense
N	137	I	139.7516206	-2.766784424	7.84E-92	1.20E-90	5	N137I	missense
N	137	K	244.6533784	-2.674509329	2.34E-149	6.38E-148	5	N137K	missense
N	137	S	739.4716907	-1.90213102	3.09E-180	1.17E-178	5	N137S	missense
N	137	T	32.47299652	-2.269738104	2.51E-38	1.11E-37	5	N137T	missense
N	137	Y	341.319142	-2.997511064	2.50E-63	2.50E-62	5	N137Y	missense
D	138	A	73.72668492	-0.334737502	0.001025217	0.002542331	5	D138A	missense
D	138	N	488.2705144	0.348574705	2.63E-09	7.69E-09	5	D138N	missense
D	138	E	297.397403	0.626589859	2.68E-15	8.82E-15	5	D138E	missense
D	138	G	934.6093532	-0.450103368	1.17E-26	4.35E-26	5	D138G	missense
D	138	Y	82.5186223	-0.301933412	0.006474995	0.015211592	5	D138Y	missense
D	138	V	409.923861	-1.87347476	9.85E-82	1.27E-80	5	D138V	missense
W	139	R	1566.50297	-1.982597789	1.92E-302	3.15E-300	5	W139R	missense
W	139	C	677.4017847	-1.091941999	1.61E-111	3.29E-110	5	W139C	missense
W	139	G	100.6222637	-2.726071542	7.81E-78	9.35E-77	5	W139G	missense
W	139	L	393.6865504	-0.588536419	1.67E-14	5.37E-14	5	W139L	missense
W	139	S	92.48949227	-1.389595977	1.19E-35	5.03E-35	5	W139S	missense
V	140	A	1655.2562	-0.457248788	4.75E-37	2.03E-36	5	V140A	missense
V	140	E	375.7343327	-2.492439642	9.62E-132	2.36E-130	5	V140E	missense
V	140	G	91.67613129	-1.351025997	1.41E-33	5.62E-33	5	V140G	missense
V	140	L	129.2484266	-0.716575682	1.49E-08	4.25E-08	5	V140L	missense
V	140	M	574.1979825	-0.909877031	5.09E-22	1.80E-21	5	V140M	missense
K	141	R	2266.492738	0.49296027	1.86E-30	7.18E-30	5	K141R	missense
K	141	N	333.7582663	0.436681384	8.15E-09	2.35E-08	5	K141N	missense
K	141	E	2360.490946	0.728297004	2.34E-34	9.49E-34	5	K141E	missense
K	141	Q	139.2784508	0.738111935	1.84E-14	5.85E-14	5	K141Q	missense
K	141	M	1352.861188	0.276269759	1.12E-12	3.44E-12	5	K141M	missense
K	141	T	169.723104	0.44407105	2.21E-06	5.96E-06	5	K141T	missense
T	142	A	1550.450785	0.461450859	7.69E-26	2.82E-25	5	T142A	missense
T	142	R	110.7263888	0.27863966	0.001665104	0.004108372	5	T142R	missense
T	142	I	799.1672633	0.231983115	4.52E-06	1.20E-05	5	T142I	missense
T	142	K	85.00866872	0.54836443	6.07E-04	0.001537535	5	T142K	missense
T	142	P	43.81665768	-2.377361465	2.90E-51	1.45E-50	5	T142P	missense
T	142	S	944.0162173	0.655946334	2.12E-58	1.86E-57	5	T142S	missense
H	143	R	2117.277091	0.392479252	4.08E-10	1.20E-09	5	H143R	missense
H	143	N	163.7217014	0.908915484	6.48E-21	2.27E-20	5	H143N	missense
H	143	D	107.3000248	-0.427288124	9.33E-05	2.40E-04	5	H143D	missense
H	143	Q	523.4124878	1.041537273	3.06E-47	1.49E-46	5	H143Q	missense
H	143	L	597.8880588	-1.758223732	6.04E-293	7.41E-291	5	H143L	missense
H	143	P	109.4690277	-2.598933503	9.85E-120	2.10E-118	5	H143P	missense
H	143	Y	542.0627389	-1.089900874	6.00E-90	8.66E-89	5	H143Y	missense
T	144	A	755.6971902	-2.068275226	1.05E-210	6.46E-209	5	T144A	missense
T	144	R	45.26455781	-2.739775677	2.37E-51	1.20E-50	5	T144R	missense
T	144	I	252.6368175	-2.384159905	1.74E-200	9.52E-199	5	T144I	missense
T	144	K	25.95234075	-1.439371166	2.50E-12	7.63E-12	5	T144K	missense
T	144	P	57.58774478	-3.056365945	5.10E-78	6.27E-77	5	T144P	missense
K	145	R	1518.749405	0.980279147	3.83E-73	2.33E-72	6	K145R	missense
K	145	N	3505.55482	1.684888248	7.51E-121	6.43E-120	6	K145N	missense
K	145	E	1748.415071	0.31698992	6.58E-08	1.78E-07	6	K145E	missense
K	145	Q	327.9879251	1.046889941	5.43E-46	2.59E-45	6	K145Q	missense
K	145	I	307.0612688	-1.771345295	8.98E-126	7.95E-125	6	K145I	missense
K	145	T	143.4743227	-0.737865034	7.58E-17	2.45E-16	6	K145T	missense
G	146	A	76.47011015	-0.976384007	4.37E-20	1.43E-19	6	G146A	missense
G	146	R	21.45739629	-0.695473515	4.89E-04	0.001175783	6	G146R	missense
G	146	D	483.4672264	-0.117916002	0.013514216	0.029544065	6	G146D	missense
G	146	C	262.359895	-0.367191242	2.19E-10	6.17E-10	6	G146C	missense
G	146	S	324.6752881	-0.53330527	7.79E-17	2.51E-16	6	G146S	missense
G	146	V	63.42287521	-0.975785297	6.34E-14	1.95E-13	6	G146V	missense
M	147	R	314.8026712	1.630365959	2.45E-101	1.87E-100	6	M147R	missense
M	147	I	395.2304021	-0.779535747	1.91E-16	6.10E-16	6	M147I	missense
M	147	L	278.6739867	-0.720472471	2.51E-33	9.98E-33	6	M147L	missense
M	147	K	2027.388688	1.826426052	4.00E-161	4.21E-160	6	M147K	missense
M	147	T	1452.78375	0.389520971	1.91E-23	6.53E-23	6	M147T	missense
M	147	V	615.8780123	-0.859024349	5.93E-31	2.28E-30	6	M147V	missense
I	148	N	1140.019814	0.118001945	0.0021941	0.005059454	6	I148N	missense
I	148	L	58.52166948	-0.290792403	0.022467331	0.047672278	6	I148L	missense
I	148	F	802.9802591	-0.323517408	1.48E-11	4.36E-11	6	I148F	missense
I	148	T	1347.399625	0.206617047	2.86E-06	7.45E-06	6	I148T	missense
I	148	V	1468.585493	0.417597536	8.54E-22	2.88E-21	6	I148V	missense
S	149	R	508.5389089	0.673330946	1.56E-23	5.36E-23	6	S149R	missense
S	149	N	1034.150114	0.97688761	1.18E-145	1.15E-144	6	S149N	missense
S	149	C	1343.14637	0.935796254	4.93E-163	5.29E-162	6	S149C	missense
S	149	G	2069.926372	0.867234964	2.65E-83	1.74E-82	6	S149G	missense
S	149	I	280.7784952	0.517570783	1.69E-10	4.80E-10	6	S149I	missense
S	149	T	88.81092629	1.215795339	7.67E-40	3.34E-39	6	S149T	missense
N	150	D	2482.060919	1.43533921	2.01E-177	2.31E-176	6	N150D	missense
N	150	I	463.8386567	-1.762312843	6.64E-69	3.85E-68	6	N150I	missense
N	150	K	88.85081228	-0.368719041	2.86E-04	6.98E-04	6	N150K	missense
N	150	S	1317.03747	0.264061365	6.99E-12	2.08E-11	6	N150S	missense
N	150	Y	396.4020373	-1.108735242	1.54E-78	9.74E-78	6	N150Y	missense
L	151	M	3942.668663	1.935640565	3.43E-225	4.56E-224	6	L151M	missense
L	151	F	413.9309292	1.666525667	3.79E-107	3.14E-106	6	L151F	missense
L	151	S	1307.174872	-0.2448621	3.37E-06	8.73E-06	6	L151S	missense
L	151	W	44.87422333	-2.037630217	4.87E-39	2.10E-38	6	L151W	missense
L	151	V	373.2880628	1.881026054	2.28E-159	2.35E-158	6	L151V	missense
L	152	R	136.1807702	-0.887506956	8.35E-23	2.83E-22	6	L152R	missense
L	152	H	843.9365653	-0.615215235	1.53E-23	5.28E-23	6	L152H	missense
L	152	I	341.7715165	0.826298347	2.49E-53	1.30E-52	6	L152I	missense
L	152	F	507.3574322	-0.300421554	1.07E-07	2.88E-07	6	L152F	missense
L	152	P	1119.934046	-1.372255431	3.73E-121	3.25E-120	6	L152P	missense
L	152	V	81.07575365	0.734738604	1.93E-09	5.32E-09	6	L152V	missense
G	153	A	121.7620024	1.265919465	1.16E-37	4.88E-37	6	G153A	missense
G	153	R	1202.462406	1.232075374	6.67E-106	5.26E-105	6	G153R	missense
G	153	E	1354.37713	1.529426967	8.95E-199	1.10E-197	6	G153E	missense
G	153	W	325.2606202	0.352818793	1.53E-07	4.09E-07	6	G153W	missense
G	153	V	932.6733375	0.547964705	1.64E-28	6.07E-28	6	G153V	missense
K	154	R	2288.15041	0.677967084	6.65E-56	3.54E-55	6	K154R	missense
K	154	N	899.6408433	0.518530488	2.05E-30	7.85E-30	6	K154N	missense
K	154	E	3040.320032	1.306003383	2.93E-164	3.22E-163	6	K154E	missense
K	154	Q	94.78916081	0.789310203	4.55E-13	1.36E-12	6	K154Q	missense
K	154	I	2961.084704	1.003397495	3.74E-25	1.34E-24	6	K154I	missense
K	154	T	414.2973521	1.299376989	1.35E-42	6.02E-42	6	K154T	missense
G	155	R	297.8637394	-0.278732797	3.06E-07	8.13E-07	6	G155R	missense
G	155	E	387.4168305	0.463967764	1.52E-13	4.61E-13	6	G155E	missense
G	155	V	70.65978662	-0.431226259	0.00109329	0.00257996	6	G155V	missense
A	156	D	420.8524855	1.162590209	1.95E-43	8.89E-43	6	A156D	missense
A	156	G	126.9174322	0.243301538	0.009786769	0.021772328	6	A156G	missense
A	156	P	43.81252608	-1.01876121	4.56E-13	1.36E-12	6	A156P	missense
A	156	S	374.9816269	1.367802863	2.83E-106	2.27E-105	6	A156S	missense
A	156	T	976.9123126	1.10946584	1.37E-90	1.00E-89	6	A156T	missense
V	157	A	1208.809423	-0.927394905	2.96E-101	2.23E-100	6	V157A	missense
V	157	E	294.3235266	-1.467533432	8.10E-65	4.55E-64	6	V157E	missense
V	157	G	65.60066243	-1.722021411	2.13E-44	9.86E-44	6	V157G	missense
V	157	L	389.7878112	0.657512599	2.57E-08	6.97E-08	6	V157L	missense
D	158	A	40.76141281	-1.334424786	2.00E-15	6.36E-15	6	D158A	missense
D	158	N	707.3473891	0.720576256	4.43E-50	2.19E-49	6	D158N	missense
D	158	E	155.2653132	-0.677633982	2.28E-13	6.90E-13	6	D158E	missense
D	158	G	1070.37998	-0.634977146	6.57E-38	2.79E-37	6	D158G	missense
D	158	Y	112.9157319	-1.205356288	9.94E-26	3.61E-25	6	D158Y	missense
D	158	V	302.5462923	-1.627936267	1.33E-78	8.48E-78	6	D158V	missense
Q	159	R	1835.696444	0.582704058	2.09E-54	1.10E-53	6	Q159R	missense
Q	159	E	100.2795678	1.168748342	2.08E-26	7.61E-26	6	Q159E	missense
Q	159	H	803.477022	1.035495062	1.13E-77	7.05E-77	6	Q159H	missense
Q	159	L	547.2170264	-1.977355803	5.28E-84	3.51E-83	6	Q159L	missense
Q	159	K	462.0886058	0.67571424	2.81E-24	9.91E-24	6	Q159K	missense
Q	159	P	317.5298612	1.249622719	4.42E-73	2.66E-72	6	Q159P	missense
L	160	R	350.9307065	1.422082583	1.13E-47	5.50E-47	6	L160R	missense
L	160	Q	2468.045928	1.737794914	8.51E-147	8.42E-146	6	L160Q	missense
L	160	M	624.4463057	1.533479893	8.67E-107	7.06E-106	6	L160M	missense
L	160	P	1649.904829	-0.710161753	9.73E-24	3.39E-23	6	L160P	missense
L	160	V	127.6137021	0.697465696	1.46E-13	4.46E-13	6	L160V	missense
T	161	A	1087.090926	-0.55668929	5.95E-45	2.81E-44	6	T161A	missense
T	161	R	45.78929433	-2.382221013	3.74E-32	1.45E-31	6	T161R	missense
T	161	I	224.6853133	-2.291702143	5.73E-103	4.45E-102	6	T161I	missense
T	161	K	39.28233313	-1.405939439	2.04E-11	6.00E-11	6	T161K	missense
T	161	P	46.53360102	-2.509331062	6.37E-52	3.25E-51	6	T161P	missense
T	161	S	796.2509926	0.21012904	3.01E-05	7.52E-05	6	T161S	missense
R	162	Q	1220.145649	0.176146321	7.78E-06	1.99E-05	6	R162Q	missense
R	162	G	110.4235919	0.307547723	2.91E-04	7.08E-04	6	R162G	missense
R	162	L	304.6949337	-1.867850585	1.97E-158	1.99E-157	6	R162L	missense
R	162	P	47.7305668	-0.777653716	4.24E-10	1.18E-09	6	R162P	missense
R	162	W	480.751065	-2.044092411	1.95E-140	1.83E-139	6	R162W	missense
L	163	R	57.35320084	-3.765101796	1.08E-86	7.36E-86	6	L163R	missense
L	163	Q	491.4057112	-2.361857338	1.00E-69	5.89E-69	6	L163Q	missense
L	163	M	435.2107981	0.803987949	2.03E-65	1.15E-64	6	L163M	missense
L	163	P	642.5448989	-3.226349492	8.13E-59	4.46E-58	6	L163P	missense
L	163	V	127.9894903	0.626829761	6.91E-11	1.99E-10	6	L163V	missense
V	164	A	848.843841	-1.236711283	9.46E-200	1.19E-198	6	V164A	missense
V	164	E	254.1415155	-2.996011002	5.13E-25	1.82E-24	6	V164E	missense
V	164	G	27.00905167	-2.639810302	9.97E-35	4.09E-34	6	V164G	missense
V	164	L	103.2434466	-0.336224266	7.22E-04	0.001719168	6	V164L	missense
V	164	M	717.2287752	-0.380073861	8.77E-11	2.52E-10	6	V164M	missense
L	165	R	60.4398449	-3.697679539	1.92E-88	1.35E-87	6	L165R	missense
L	165	Q	385.6368548	-2.717728181	6.52E-53	3.36E-52	6	L165Q	missense
L	165	M	401.324447	0.476042538	4.90E-24	1.72E-23	6	L165M	missense
L	165	P	739.0759858	-2.701540989	1.14E-181	1.33E-180	6	L165P	missense
L	165	V	161.9574308	1.855245257	1.16E-70	6.89E-70	6	L165V	missense
V	166	A	1341.354562	-0.807477271	6.83E-89	4.85E-88	6	V166A	missense
V	166	E	307.9921327	-3.288036266	7.00E-66	4.02E-65	6	V166E	missense
V	166	G	66.33522392	-2.301062967	1.05E-56	5.63E-56	6	V166G	missense
V	166	L	233.9041879	-0.49158925	2.62E-15	8.22E-15	6	V166L	missense
V	166	M	410.8978517	-1.403047763	8.83E-129	7.96E-128	6	V166M	missense
N	167	D	1419.183693	-0.430281652	7.86E-05	1.94E-04	6	N167D	missense
N	167	H	32.90343216	-2.072205673	3.60E-32	1.41E-31	6	N167H	missense
N	167	I	147.3705229	-3.710472735	7.23E-165	8.11E-164	6	N167I	missense
N	167	K	233.2341075	-2.741444422	2.78E-80	1.80E-79	6	N167K	missense
N	167	S	1177.134789	-0.777172611	6.37E-34	2.57E-33	6	N167S	missense
N	167	T	32.85333228	-2.699384616	2.34E-42	1.04E-41	6	N167T	missense
N	167	Y	246.1040172	-3.457075872	2.94E-58	1.60E-57	6	N167Y	missense
A	168	D	123.0825149	-2.2994045	3.23E-50	1.62E-49	6	A168D	missense
A	168	G	137.3124062	0.496388431	1.32E-08	3.61E-08	6	A168G	missense
A	168	P	45.07674567	-1.982852364	7.43E-27	2.74E-26	6	A168P	missense
A	168	S	134.7631083	-0.626795568	1.67E-10	4.76E-10	6	A168S	missense
A	168	T	490.5641408	-0.839618444	1.57E-61	8.72E-61	6	A168T	missense
A	168	V	546.5634759	-0.494913356	1.60E-21	5.34E-21	6	A168V	missense
L	169	R	37.11097311	-2.995284929	4.63E-49	2.27E-48	6	L169R	missense
L	169	H	1927.108892	0.350194923	0.015870392	0.034397201	6	L169H	missense
L	169	I	474.1331717	0.616050838	1.30E-44	6.06E-44	6	L169I	missense
L	169	F	797.6663104	0.593941937	5.60E-30	2.13E-29	6	L169F	missense
L	169	P	572.6067791	-2.987004714	1.67E-46	8.02E-46	6	L169P	missense
L	169	S	14.55549871	2.625228032	2.54E-10	7.14E-10	6	L169S	missense
L	169	V	67.82966206	1.048891707	1.43E-14	4.45E-14	6	L169V	missense
Y	170	N	330.8632455	-1.762983726	7.15E-75	4.40E-74	6	Y170N	missense
Y	170	D	31.74325715	-2.38620781	3.56E-36	1.47E-35	6	Y170D	missense
Y	170	C	460.1478133	-1.389363883	1.88E-85	1.26E-84	6	Y170C	missense
Y	170	H	904.9563786	-0.442990965	2.61E-21	8.66E-21	6	Y170H	missense
Y	170	F	250.699977	-1.085383934	2.40E-51	1.21E-50	6	Y170F	missense
Y	170	S	46.80167156	-0.592755194	1.56E-05	3.92E-05	6	Y170S	missense
F	171	C	50.50591787	-1.980345729	2.40E-36	1.00E-35	6	F171C	missense
F	171	I	543.3243266	-1.548188177	6.05E-89	4.36E-88	6	F171I	missense
F	171	L	1624.015699	-0.176877488	8.37E-06	2.13E-05	6	F171L	missense
F	171	S	1054.45739	-1.951747388	0	0	6	F171S	missense
F	171	V	48.74535796	-1.955388751	4.29E-38	1.84E-37	6	F171V	missense
N	172	D	1166.56319	-0.386823706	4.01E-21	1.32E-20	6	N172D	missense
N	172	H	168.6378865	0.956277763	2.09E-15	6.58E-15	6	N172H	missense
N	172	I	129.6710073	-2.351277646	2.46E-129	2.26E-128	6	N172I	missense
N	172	K	376.2902548	0.930710786	1.57E-29	5.88E-29	6	N172K	missense
N	172	S	949.188263	-0.453319988	6.99E-30	2.64E-29	6	N172S	missense
N	172	T	33.08638454	-1.074793272	3.79E-10	1.06E-09	6	N172T	missense
N	172	Y	260.4045341	-1.549417726	2.16E-87	1.49E-86	6	N172Y	missense
G	173	A	76.01142128	-0.45009235	1.03E-05	2.60E-05	6	G173A	missense
G	173	R	24.29328881	-1.679626934	9.73E-20	3.17E-19	6	G173R	missense
G	173	D	582.8268944	-1.505577056	1.14E-143	1.09E-142	6	G173D	missense
G	173	C	283.4915732	-1.218351787	3.77E-95	2.80E-94	6	G173C	missense
G	173	S	617.6902126	-1.106623616	5.64E-34	2.30E-33	6	G173S	missense
G	173	V	290.2832604	-0.506899884	6.54E-09	1.79E-08	6	G173V	missense
Q	174	R	1268.507883	0.473085749	3.74E-15	1.16E-14	6	Q174R	missense
Q	174	E	99.64498486	0.672095145	4.00E-11	1.16E-10	6	Q174E	missense
Q	174	H	468.6937986	0.605874536	1.01E-25	3.63E-25	6	Q174H	missense
Q	174	L	889.0154492	-0.699478505	1.24E-42	5.57E-42	6	Q174L	missense
Q	174	K	498.8236057	0.612975618	3.69E-33	1.45E-32	6	Q174K	missense
Q	174	P	309.6220983	-0.584955856	1.74E-06	4.57E-06	6	Q174P	missense
W	175	R	934.570058	-3.387016671	1.14E-287	1.44E-285	6	W175R	missense
W	175	C	266.4906623	-2.850373185	4.92E-295	8.28E-293	6	W175C	missense
W	175	G	38.17537535	-3.215653079	1.94E-43	8.89E-43	6	W175G	missense
W	175	L	1807.842361	-0.521867383	2.83E-06	7.40E-06	6	W175L	missense
W	175	S	60.22311959	-1.969821773	6.67E-34	2.68E-33	6	W175S	missense
K	176	E	9118.989186	1.430075249	2.60E-35	1.20E-34	7	K176E	missense
K	176	Q	165.4604088	0.997787712	1.74E-17	5.90E-17	7	K176Q	missense
K	176	T	92.26507991	-0.368037524	5.82E-04	0.001500082	7	K176T	missense
T	177	A	1365.054132	0.456935802	1.24E-20	4.41E-20	7	T177A	missense
T	177	N	142.4803437	0.937193913	7.56E-17	2.52E-16	7	T177N	missense
T	177	I	494.9916418	0.226545499	1.34E-05	3.64E-05	7	T177I	missense
T	177	P	28.66156991	-2.071150707	5.63E-26	2.26E-25	7	T177P	missense
T	177	S	777.1243429	0.739293701	5.80E-27	2.40E-26	7	T177S	missense
P	178	A	69.6201724	0.850273478	1.56E-07	4.38E-07	7	P178A	missense
P	178	H	515.9412549	-0.452011291	2.74E-08	7.80E-08	7	P178H	missense
P	178	L	337.3248677	-1.133294008	7.68E-80	1.92E-78	7	P178L	missense
P	178	S	731.166116	0.272596082	8.40E-04	0.002155432	7	P178S	missense
P	178	T	127.2674253	-0.383888857	1.89E-04	4.96E-04	7	P178T	missense
F	179	C	26.60359534	-2.710667322	5.84E-35	2.65E-34	7	F179C	missense
F	179	I	311.7825032	-2.51200504	5.63E-177	9.86E-175	7	F179I	missense
F	179	L	800.3885476	-2.44961857	1.37E-72	1.15E-71	7	F179L	missense
F	179	S	672.6544874	-2.776006143	5.65E-77	1.02E-75	7	F179S	missense
F	179	Y	331.6872832	-1.918411303	1.32E-26	5.40E-26	7	F179Y	missense
F	179	V	47.28075182	-3.024123824	1.07E-42	5.43E-42	7	F179V	missense
P	180	A	79.79632222	0.869243008	4.69E-11	1.40E-10	7	P180A	missense
P	180	H	480.8655568	0.430576711	1.26E-11	3.77E-11	7	P180H	missense
P	180	L	801.10372	0.627911798	2.50E-24	9.62E-24	7	P180L	missense
P	180	S	740.1141817	0.543383899	1.94E-24	7.50E-24	7	P180S	missense
D	181	A	200.2942262	1.299303532	1.95E-25	7.72E-25	7	D181A	missense
D	181	N	1408.841583	0.709361857	3.49E-25	1.37E-24	7	D181N	missense
D	181	E	544.1664553	1.445541167	2.52E-48	1.34E-47	7	D181E	missense
D	181	G	1620.103933	0.502012779	2.73E-16	8.98E-16	7	D181G	missense
D	181	H	106.0535567	0.918707953	4.01E-10	1.17E-09	7	D181H	missense
D	181	Y	743.8431284	0.801165047	8.11E-32	3.55E-31	7	D181Y	missense
D	181	V	1937.920755	1.288580917	2.30E-56	1.47E-55	7	D181V	missense
S	182	A	119.6433784	1.08015107	1.19E-21	4.39E-21	7	S182A	missense
S	182	C	15.85229259	0.649345492	0.006491455	0.015735047	7	S182C	missense
S	182	F	501.8328995	0.144616883	0.018007227	0.041725997	7	S182F	missense
S	182	P	1078.726588	-0.450835332	6.18E-16	1.98E-15	7	S182P	missense
S	182	T	1307.485058	0.805250083	8.96E-56	5.61E-55	7	S182T	missense
S	182	Y	182.4296897	0.463619535	1.28E-10	3.76E-10	7	S182Y	missense
S	183	R	730.708118	0.438473584	4.55E-11	1.36E-10	7	S183R	missense
S	183	N	1761.870511	1.22812166	1.74E-67	1.37E-66	7	S183N	missense
S	183	C	1256.461556	0.66385232	2.51E-21	9.11E-21	7	S183C	missense
S	183	G	2697.076465	0.95620955	1.32E-68	1.06E-67	7	S183G	missense
S	183	I	322.0464608	-0.464727532	1.60E-15	5.07E-15	7	S183I	missense
S	183	T	72.35816049	0.285502176	0.005329815	0.013039455	7	S183T	missense
T	184	A	698.7949068	-1.373025562	2.76E-120	1.45E-118	7	T184A	missense
T	184	P	41.73925607	-2.252651397	2.74E-52	1.55E-51	7	T184P	missense
T	184	S	553.5616282	-0.596916492	1.09E-31	4.73E-31	7	T184S	missense
H	185	R	1078.576379	0.261935422	4.42E-06	1.23E-05	7	H185R	missense
H	185	N	208.0953737	-0.576773324	5.13E-11	1.52E-10	7	H185N	missense
H	185	D	40.14856907	-0.671049298	2.30E-05	6.24E-05	7	H185D	missense
H	185	Q	324.8372047	0.559459772	7.67E-17	2.54E-16	7	H185Q	missense
H	185	L	385.0737717	-0.90538133	9.36E-64	6.93E-63	7	H185L	missense
H	185	P	46.25688148	-2.908550639	1.09E-49	5.93E-49	7	H185P	missense
H	185	Y	499.6967272	-0.895813035	5.42E-57	3.52E-56	7	H185Y	missense
R	186	C	3389.439072	1.041791964	2.88E-24	1.10E-23	7	R186C	missense
R	186	H	2393.320584	1.167273827	3.18E-41	1.58E-40	7	R186H	missense
R	186	L	1246.496831	1.382426868	5.81E-56	3.68E-55	7	R186L	missense
R	186	P	112.8283251	0.994953004	0.001309812	0.003328314	7	R186P	missense
R	186	S	1244.87809	1.03562434	3.50E-50	1.94E-49	7	R186S	missense
R	187	C	554.5795105	-2.430574692	4.14E-77	7.77E-76	7	R187C	missense
R	187	H	604.5738725	-1.110678854	1.02E-47	5.38E-47	7	R187H	missense
R	187	L	191.7947108	-1.393987566	6.48E-23	2.40E-22	7	R187L	missense
R	187	P	65.61394613	-3.039103678	2.35E-74	2.02E-73	7	R187P	missense
R	187	S	269.3034356	-2.062100731	1.44E-60	9.81E-60	7	R187S	missense
L	188	H	314.5005442	-0.147688417	0.008816258	0.020983491	7	L188H	missense
L	188	I	391.6123357	0.748038338	1.59E-43	8.22E-43	7	L188I	missense
L	188	P	2466.967565	0.837597038	6.36E-27	2.61E-26	7	L188P	missense
L	188	V	32.60954821	0.715249934	1.13E-05	3.12E-05	7	L188V	missense
F	189	C	28.34349718	-3.391044593	8.41E-39	4.06E-38	7	F189C	missense
F	189	I	275.861555	-3.999449747	1.82E-111	7.98E-110	7	F189I	missense
F	189	L	835.7307555	-3.177899267	1.40E-141	9.17E-140	7	F189L	missense
F	189	S	611.604214	-3.113601317	5.23E-95	1.62E-93	7	F189S	missense
F	189	Y	333.2730678	-3.18507377	3.72E-82	1.03E-80	7	F189Y	missense
F	189	V	37.93815861	-3.537074719	3.00E-54	1.81E-53	7	F189V	missense
H	190	R	1108.412012	-0.327759519	3.81E-16	1.24E-15	7	H190R	missense
H	190	N	511.8564687	-0.414288457	8.25E-20	2.89E-19	7	H190N	missense
H	190	D	47.32941584	-2.361439758	1.05E-49	5.76E-49	7	H190D	missense
H	190	Q	154.8321639	-0.648430192	8.83E-18	3.02E-17	7	H190Q	missense
H	190	L	484.83214	-1.456758413	6.84E-42	3.43E-41	7	H190L	missense
H	190	P	62.58293468	-4.025295035	5.93E-55	3.63E-54	7	H190P	missense
H	190	Y	1462.344826	1.070448586	1.84E-27	7.69E-27	7	H190Y	missense
K	191	R	1127.844286	0.48566938	1.65E-15	5.20E-15	7	K191R	missense
K	191	N	239.4682354	-1.354260827	1.22E-52	7.03E-52	7	K191N	missense
K	191	E	584.0883398	-2.505923427	5.49E-183	1.44E-180	7	K191E	missense
K	191	Q	65.42199531	-1.370116841	6.21E-29	2.61E-28	7	K191Q	missense
K	191	I	436.8776396	-1.642741323	1.18E-23	4.41E-23	7	K191I	missense
K	191	T	65.57166348	-1.314384803	4.62E-30	1.99E-29	7	K191T	missense
S	192	A	110.8745894	1.397100273	2.68E-21	9.65E-21	7	S192A	missense
S	192	L	539.6860834	0.885515549	1.83E-25	7.29E-25	7	S192L	missense
S	192	P	1373.495571	0.724082597	2.35E-35	1.09E-34	7	S192P	missense
S	192	T	773.1183913	0.812366559	3.44E-32	1.52E-31	7	S192T	missense
D	193	A	31.02286214	-2.625339681	6.93E-36	3.25E-35	7	D193A	missense
D	193	E	181.25462	-1.699229678	2.01E-55	1.24E-54	7	D193E	missense
D	193	G	588.764917	-1.297308203	1.04E-98	3.91E-97	7	D193G	missense
D	193	H	19.47217457	-1.82582423	5.79E-17	1.94E-16	7	D193H	missense
D	193	Y	121.2553495	-2.716054588	9.81E-63	7.07E-62	7	D193Y	missense
D	193	V	167.1325357	-2.802820997	1.59E-75	1.58E-74	7	D193V	missense
G	194	A	46.99657114	-1.099339381	5.43E-16	1.75E-15	7	G194A	missense
G	194	R	24.90861141	-0.815921479	3.66E-06	1.03E-05	7	G194R	missense
G	194	D	379.281019	-1.430864059	1.28E-52	7.34E-52	7	G194D	missense
G	194	C	193.893972	-1.505410229	1.85E-95	6.10E-94	7	G194C	missense
G	194	S	669.0611863	-1.125693552	1.63E-66	1.26E-65	7	G194S	missense
G	194	V	129.6393454	-2.335892391	6.26E-103	2.53E-101	7	G194V	missense
S	195	C	490.6987736	-0.708680269	8.62E-41	4.24E-40	7	S195C	missense
S	195	I	223.3938486	-0.809446153	3.01E-35	1.38E-34	7	S195I	missense
S	195	T	174.7570021	1.067054146	3.91E-25	1.52E-24	7	S195T	missense
T	196	A	1223.281991	0.372540555	4.46E-10	1.30E-09	7	T196A	missense
T	196	I	516.5390716	0.14246311	0.001041843	0.002660239	7	T196I	missense
T	196	P	52.67821086	-1.492816585	2.91E-29	1.23E-28	7	T196P	missense
T	196	S	1079.869478	0.480879365	3.22E-26	1.30E-25	7	T196S	missense
V	197	A	878.9039637	-0.60940579	1.81E-14	5.56E-14	7	V197A	missense
V	197	D	320.3152699	-1.23704233	1.76E-64	1.34E-63	7	V197D	missense
V	197	G	30.78972476	-2.701469793	1.82E-21	6.65E-21	7	V197G	missense
V	197	I	1114.431379	0.988121748	1.64E-32	7.30E-32	7	V197I	missense
S	198	A	113.1887587	0.79871736	6.25E-14	1.89E-13	7	S198A	missense
S	198	C	112.8105566	1.249573022	2.12E-14	6.45E-14	7	S198C	missense
S	198	F	780.8890523	0.891575696	1.11E-18	3.86E-18	7	S198F	missense
S	198	P	1472.415562	0.406415535	5.23E-16	1.70E-15	7	S198P	missense
S	198	T	1074.825313	0.807078472	3.59E-36	1.70E-35	7	S198T	missense
S	198	Y	664.5003537	1.178123487	8.02E-51	4.49E-50	7	S198Y	missense
V	199	A	826.8010815	-0.978726253	2.16E-58	1.44E-57	7	V199A	missense
V	199	E	358.2839475	-2.746433799	2.46E-69	2.02E-68	7	V199E	missense
V	199	G	46.94684277	-3.50530541	2.87E-74	2.44E-73	7	V199G	missense
V	199	L	75.91627211	-0.602256305	9.14E-09	2.61E-08	7	V199L	missense
V	199	M	358.4355349	-1.834229891	5.57E-147	4.18E-145	7	V199M	missense
P	200	L	1019.742278	0.252214382	4.66E-04	0.001213004	7	P200L	missense
P	200	T	252.512669	0.198397822	0.006676258	0.016108769	7	P200T	missense
M	201	R	43.7911708	-4.007529004	4.04E-62	2.87E-61	7	M201R	missense
M	201	I	328.2694569	-2.412702212	5.06E-80	1.33E-78	7	M201I	missense
M	201	L	245.0494414	-3.817344856	9.49E-160	9.98E-158	7	M201L	missense
M	201	K	293.0157039	-3.872977432	4.61E-86	1.35E-84	7	M201K	missense
M	201	T	539.1523067	-2.748081728	2.84E-132	1.66E-130	7	M201T	missense
M	201	V	483.8475257	-2.418683159	3.28E-173	4.31E-171	7	M201V	missense
M	202	R	45.26915025	-3.303375159	9.98E-41	4.86E-40	7	M202R	missense
M	202	I	501.9581334	-0.918633262	1.88E-60	1.27E-59	7	M202I	missense
M	202	L	367.5542764	-1.033542218	1.48E-57	9.71E-57	7	M202L	missense
M	202	K	288.235424	-2.836657448	9.66E-80	2.31E-78	7	M202K	missense
M	202	T	595.6820222	-2.262917879	3.54E-64	2.66E-63	7	M202T	missense
M	202	V	820.5563818	-0.74311665	6.61E-62	4.64E-61	7	M202V	missense
A	203	D	112.7898282	-2.011752346	3.98E-49	2.14E-48	7	A203D	missense
A	203	G	71.43979198	-0.417268152	6.77E-06	1.88E-05	7	A203G	missense
A	203	P	56.89238924	-2.46727981	7.16E-53	4.18E-52	7	A203P	missense
A	203	S	393.1521672	0.4968288	1.93E-20	6.82E-20	7	A203S	missense
A	203	T	815.2725979	0.228512002	1.68E-09	4.86E-09	7	A203T	missense
A	203	V	764.7682535	0.36061418	1.34E-18	4.62E-18	7	A203V	missense
Q	204	R	709.8365901	-1.212492534	1.87E-97	6.54E-96	7	Q204R	missense
Q	204	H	277.1491203	-0.77041969	3.98E-15	1.24E-14	7	Q204H	missense
Q	204	L	1861.830931	1.0874707	9.08E-54	5.43E-53	7	Q204L	missense
Q	204	K	100.4454109	-0.520056305	2.71E-09	7.78E-09	7	Q204K	missense
Q	204	P	62.86151961	-2.430124519	1.54E-53	9.12E-53	7	Q204P	missense
T	205	A	2247.843444	0.944665749	1.46E-32	6.58E-32	7	T205A	missense
T	205	N	148.3988458	0.659838247	5.24E-15	1.62E-14	7	T205N	missense
T	205	I	2126.728673	1.360291712	1.81E-68	1.44E-67	7	T205I	missense
T	205	P	76.12922641	-0.47557843	0.001795899	0.004541552	7	T205P	missense
T	205	S	985.991083	0.756368722	2.00E-29	8.54E-29	7	T205S	missense
N	206	D	1601.238395	0.662620873	5.30E-24	1.99E-23	7	N206D	missense
N	206	H	107.5695019	-0.2044329	0.016886306	0.039301757	7	N206H	missense
N	206	I	536.3045619	-0.85535984	3.90E-75	3.42E-74	7	N206I	missense
N	206	K	112.5927992	-0.781427913	3.64E-17	1.23E-16	7	N206K	missense
N	206	S	1845.322343	0.469700148	1.23E-20	4.41E-20	7	N206S	missense
N	206	T	94.15793588	-0.277171479	0.003565014	0.008845269	7	N206T	missense
N	206	Y	481.0426176	-0.437263089	1.90E-15	5.95E-15	7	N206Y	missense
K	207	R	1847.33318	0.806051596	3.42E-43	1.75E-42	7	K207R	missense
K	207	N	372.2793799	1.430085535	1.10E-61	7.63E-61	7	K207N	missense
K	207	E	3177.492512	1.48994069	1.76E-63	1.28E-62	7	K207E	missense
K	207	Q	240.439167	1.238061724	4.71E-24	1.78E-23	7	K207Q	missense
K	207	M	2947.405912	1.647863977	1.02E-75	1.14E-74	7	K207M	missense
K	207	T	226.955917	1.289783388	9.67E-38	4.62E-37	7	K207T	missense
F	208	C	25.64554841	-1.705836263	4.58E-18	1.58E-17	7	F208C	missense
F	208	I	537.0055351	0.415362394	1.99E-14	6.09E-14	7	F208I	missense
F	208	S	643.6848075	-2.11695788	9.15E-46	4.76E-45	7	F208S	missense
F	208	Y	609.4396685	0.516912037	1.01E-15	3.21E-15	7	F208Y	missense
N	209	D	1139.338186	-0.192875288	6.16E-07	1.68E-06	8	N209D	missense
N	209	H	70.03535077	-0.362172723	2.68E-04	6.56E-04	8	N209H	missense
N	209	I	257.4469471	-2.052233647	5.01E-79	3.56E-78	8	N209I	missense
N	209	K	143.0649687	-0.610312262	1.68E-09	4.84E-09	8	N209K	missense
N	209	S	1068.56189	-0.200289581	5.41E-04	0.001314401	8	N209S	missense
N	209	T	36.67282613	-1.64404556	7.78E-26	2.95E-25	8	N209T	missense
N	209	Y	546.018675	0.260487666	1.19E-07	3.33E-07	8	N209Y	missense
Y	210	N	472.9141695	-1.821062941	1.03E-13	3.23E-13	8	Y210N	missense
Y	210	D	32.40247298	-2.991766086	3.69E-29	1.47E-28	8	Y210D	missense
Y	210	C	812.2136663	0.275778012	2.03E-06	5.42E-06	8	Y210C	missense
Y	210	H	944.9946987	0.41684504	5.13E-21	1.78E-20	8	Y210H	missense
Y	210	F	459.2167445	0.522536061	6.03E-13	1.88E-12	8	Y210F	missense
T	211	A	1554.624588	1.173960337	7.07E-147	7.62E-146	8	T211A	missense
T	211	P	15.11032233	-3.036584431	2.99E-23	1.09E-22	8	T211P	missense
T	211	S	599.6099064	0.518841718	1.53E-32	6.51E-32	8	T211S	missense
E	212	A	191.2008274	1.229788725	2.54E-34	1.11E-33	8	E212A	missense
E	212	D	189.1678927	0.393068771	4.77E-10	1.40E-09	8	E212D	missense
E	212	Q	52.30583176	1.439198541	1.30E-17	4.33E-17	8	E212Q	missense
E	212	G	2416.037695	1.086798046	9.65E-85	7.23E-84	8	E212G	missense
E	212	K	1619.831321	1.586296875	2.58E-78	1.79E-77	8	E212K	missense
E	212	V	1145.597321	0.966913869	1.82E-106	1.58E-105	8	E212V	missense
F	213	C	103.8582445	0.526867493	1.65E-06	4.43E-06	8	F213C	missense
F	213	I	307.8443642	-0.866490572	2.33E-44	1.20E-43	8	F213I	missense
F	213	L	2964.740052	0.525079984	2.95E-41	1.47E-40	8	F213L	missense
F	213	S	1973.886419	0.228522695	2.55E-05	6.51E-05	8	F213S	missense
F	213	Y	770.8929879	0.667839315	6.10E-54	3.46E-53	8	F213Y	missense
F	213	V	49.01195347	-0.865125879	8.99E-13	2.79E-12	8	F213V	missense
T	214	A	2098.24316	0.804371162	1.84E-69	1.14E-68	8	T214A	missense
T	214	N	133.6331981	0.320929299	2.22E-04	5.47E-04	8	T214N	missense
T	214	I	1151.220101	0.900447298	1.36E-73	8.84E-73	8	T214I	missense
T	214	S	717.5471095	0.796404574	2.06E-93	1.68E-92	8	T214S	missense
T	215	A	2113.121344	0.556514689	2.99E-27	1.17E-26	8	T215A	missense
T	215	R	79.51524936	-2.500728842	1.54E-78	1.08E-77	8	T215R	missense
T	215	K	61.51494513	-1.862034447	1.21E-31	5.01E-31	8	T215K	missense
T	215	M	1412.380618	0.254223996	6.01E-09	1.72E-08	8	T215M	missense
T	215	P	75.4605374	-1.793307098	6.06E-52	3.33E-51	8	T215P	missense
T	215	S	983.2683929	0.363782719	7.40E-15	2.38E-14	8	T215S	missense
P	216	H	425.5817017	-0.203716487	0.008169235	0.018578978	8	P216H	missense
P	216	L	535.7812241	-0.313353569	9.19E-07	2.48E-06	8	P216L	missense
D	217	E	873.8129323	0.607902254	4.32E-60	2.53E-59	8	D217E	missense
D	217	H	41.99495476	-0.708531905	3.84E-07	1.06E-06	8	D217H	missense
D	217	Y	259.6454052	-1.105858576	3.00E-35	1.36E-34	8	D217Y	missense
D	217	V	385.6301912	-1.354251949	3.30E-111	2.92E-110	8	D217V	missense
G	218	A	84.20349199	-0.797854025	2.07E-17	6.79E-17	8	G218A	missense
G	218	R	45.67794841	-0.722771017	3.60E-08	1.02E-07	8	G218R	missense
G	218	D	676.1726766	-0.608987647	1.97E-32	8.28E-32	8	G218D	missense
G	218	C	266.0057351	-1.176513158	1.76E-75	1.20E-74	8	G218C	missense
G	218	S	464.2286769	-0.888866026	1.06E-73	6.94E-73	8	G218S	missense
G	218	V	163.9743662	-1.749774164	2.48E-86	1.91E-85	8	G218V	missense
H	219	R	1153.67869	0.17750539	7.38E-05	1.87E-04	8	H219R	missense
H	219	N	440.1189648	0.418299771	1.59E-10	4.79E-10	8	H219N	missense
H	219	D	63.4976679	0.498077332	2.21E-06	5.86E-06	8	H219D	missense
H	219	Q	861.7012182	0.478881665	1.79E-30	7.32E-30	8	H219Q	missense
H	219	L	567.0109061	0.279353237	4.60E-10	1.35E-09	8	H219L	missense
H	219	P	42.79350513	-1.858545294	3.53E-38	1.68E-37	8	H219P	missense
H	219	Y	776.468655	0.449742233	2.93E-22	1.05E-21	8	H219Y	missense
Y	220	N	707.9336818	1.366392732	2.94E-111	2.64E-110	8	Y220N	missense
Y	220	D	50.14213762	0.67828602	2.36E-07	6.53E-07	8	Y220D	missense
Y	220	C	1174.264863	1.020348618	3.78E-50	2.02E-49	8	Y220C	missense
Y	220	H	1219.803586	1.086781447	9.87E-176	6.65E-174	8	Y220H	missense
Y	220	F	353.4413876	0.705879565	2.98E-27	1.17E-26	8	Y220F	missense
Y	220	S	61.30701683	1.487755085	2.82E-36	1.31E-35	8	Y220S	missense
Y	221	N	672.4195018	-1.557133798	1.32E-68	8.00E-68	8	Y221N	missense
Y	221	D	26.00552225	-3.788806429	4.06E-42	2.07E-41	8	Y221D	missense
Y	221	C	4612.812421	0.859757527	3.10E-16	1.01E-15	8	Y221C	missense
Y	221	H	1363.71391	-0.49376606	6.95E-07	1.89E-06	8	Y221H	missense
Y	221	F	548.75303	1.303816983	8.58E-150	9.84E-149	8	Y221F	missense
Y	221	S	62.73079311	-1.362010418	3.82E-15	1.23E-14	8	Y221S	missense
D	222	A	183.6186328	0.456460315	7.77E-04	0.001878109	8	D222A	missense
D	222	N	3759.301067	1.210802413	4.93E-54	2.82E-53	8	D222N	missense
D	222	E	297.8857478	1.131712687	3.65E-36	1.68E-35	8	D222E	missense
D	222	G	3976.701146	0.986018285	9.23E-31	3.80E-30	8	D222G	missense
D	222	H	155.4097334	1.69788	7.62E-24	2.81E-23	8	D222H	missense
D	222	Y	1173.279877	1.336036369	7.92E-40	3.85E-39	8	D222Y	missense
D	222	V	2386.776447	0.830887385	3.89E-18	1.32E-17	8	D222V	missense
I	223	N	171.6298493	-3.718969961	2.06E-74	1.37E-73	8	I223N	missense
I	223	L	44.12175652	-0.853211257	1.68E-09	4.84E-09	8	I223L	missense
I	223	M	19.55554839	-1.321395018	1.74E-10	5.22E-10	8	I223M	missense
I	223	F	166.4408905	-2.740375235	1.76E-149	1.97E-148	8	I223F	missense
I	223	S	18.56763308	-3.588075304	1.07E-32	4.58E-32	8	I223S	missense
I	223	T	810.917005	-1.44333621	3.60E-136	3.73E-135	8	I223T	missense
I	223	V	2502.258115	1.303414219	4.89E-87	3.82E-86	8	I223V	missense
L	224	R	50.87212773	-3.015049922	4.90E-53	2.72E-52	8	L224R	missense
L	224	Q	357.6825579	-3.437618081	2.76E-91	2.22E-90	8	L224Q	missense
L	224	M	489.501415	-0.126232893	0.001771603	0.004225194	8	L224M	missense
L	224	P	737.0614734	-3.165175669	3.08E-212	8.31E-210	8	L224P	missense
L	224	V	136.2586687	1.243746615	1.59E-40	7.84E-40	8	L224V	missense
E	225	A	23.27069119	-2.93076899	8.31E-34	3.61E-33	8	E225A	missense
E	225	D	207.8558277	-1.614202073	1.24E-81	9.03E-81	8	E225D	missense
E	225	Q	10.88554443	-0.736281382	0.007860626	0.01795287	8	E225Q	missense
E	225	G	554.7534848	-2.65500309	2.23E-113	2.04E-112	8	E225G	missense
E	225	K	209.0685648	-3.035799823	2.87E-123	2.87E-122	8	E225K	missense
E	225	V	210.7518676	-3.070110257	2.66E-119	2.56E-118	8	E225V	missense
L	226	R	33.58533423	-3.041357975	1.63E-51	8.77E-51	8	L226R	missense
L	226	Q	373.9736047	-3.072153066	6.97E-45	3.61E-44	8	L226Q	missense
L	226	P	609.2920148	-3.318843724	1.98E-152	2.32E-151	8	L226P	missense
L	226	V	130.4970882	0.728219152	1.18E-17	3.94E-17	8	L226V	missense
P	227	A	66.77367782	-0.380505398	0.002688259	0.006355138	8	P227A	missense
P	227	R	40.71020529	-0.746107315	2.49E-06	6.55E-06	8	P227R	missense
P	227	H	308.4097137	-1.349384299	2.45E-94	2.03E-93	8	P227H	missense
P	227	L	418.5440989	-0.908110193	1.16E-20	3.99E-20	8	P227L	missense
P	227	S	567.9756291	-0.761100873	1.94E-38	9.33E-38	8	P227S	missense
P	227	T	141.8625611	-1.024554407	1.48E-34	6.55E-34	8	P227T	missense
Y	228	N	577.7314352	-1.767800658	4.06E-79	2.92E-78	8	Y228N	missense
Y	228	D	38.4594461	-2.280631153	6.19E-35	2.78E-34	8	Y228D	missense
Y	228	C	1371.937742	-0.621434916	1.90E-10	5.66E-10	8	Y228C	missense
Y	228	H	916.6710964	-1.715451938	3.78E-193	5.09E-191	8	Y228H	missense
Y	228	S	42.73157304	-1.65360161	9.73E-18	3.28E-17	8	Y228S	missense
H	229	R	1685.917342	0.564911785	1.51E-18	5.15E-18	8	H229R	missense
H	229	Q	353.4494317	0.205071686	2.01E-04	4.98E-04	8	H229Q	missense
H	229	L	658.6867607	-0.241690934	2.24E-06	5.91E-06	8	H229L	missense
H	229	P	139.5761793	-1.620876652	9.72E-26	3.66E-25	8	H229P	missense
H	229	Y	573.7821658	-0.133604909	0.019362521	0.042597546	8	H229Y	missense
G	230	A	53.35921749	0.46343209	0.005585037	0.01286468	8	G230A	missense
G	230	R	1331.65619	-0.326450353	4.38E-05	1.11E-04	8	G230R	missense
G	230	E	1567.047355	0.546643862	3.79E-08	1.07E-07	8	G230E	missense
G	230	W	826.2727306	-0.97864215	1.64E-24	6.11E-24	8	G230W	missense
D	231	A	42.27625505	-0.908444799	1.47E-13	4.61E-13	8	D231A	missense
D	231	N	524.0250126	0.289007178	6.23E-11	1.89E-10	8	D231N	missense
D	231	E	115.5096847	0.631406738	1.44E-14	4.58E-14	8	D231E	missense
D	231	G	1220.611796	0.14561413	0.001228099	0.002955113	8	D231G	missense
D	231	Y	87.60699517	-0.621838934	3.14E-10	9.29E-10	8	D231Y	missense
D	231	V	244.9588083	-1.985150846	1.03E-71	6.51E-71	8	D231V	missense
T	232	A	2201.937402	0.551891216	3.14E-22	1.11E-21	8	T232A	missense
T	232	N	112.7247126	0.677783184	2.36E-07	6.53E-07	8	T232N	missense
T	232	I	2431.812438	0.977053219	1.08E-34	4.79E-34	8	T232I	missense
T	232	P	33.22143538	-2.130707716	9.72E-30	3.91E-29	8	T232P	missense
T	232	S	686.0839018	0.487306964	6.74E-21	2.33E-20	8	T232S	missense
L	233	R	70.90907917	-1.479919043	2.34E-26	8.95E-26	8	L233R	missense
L	233	H	1162.726239	-0.302502362	1.29E-07	3.62E-07	8	L233H	missense
L	233	I	476.6396254	0.411738094	1.16E-12	3.59E-12	8	L233I	missense
L	233	F	1578.420547	1.577422464	1.41E-139	1.49E-138	8	L233F	missense
L	233	P	509.9992339	-3.141817044	1.64E-259	8.82E-257	8	L233P	missense
L	233	V	121.1224427	0.719743755	1.43E-11	4.35E-11	8	L233V	missense
S	234	R	152.065942	-2.418795109	1.91E-40	9.38E-40	8	S234R	missense
S	234	N	338.0725668	-1.987000739	1.68E-62	1.01E-61	8	S234N	missense
S	234	C	337.7049718	-2.038459796	1.28E-204	2.30E-202	8	S234C	missense
S	234	G	790.7843336	-1.336458078	2.97E-155	3.56E-154	8	S234G	missense
S	234	I	186.4498263	-2.529994924	1.20E-84	8.85E-84	8	S234I	missense
S	234	T	98.69555675	-0.750664433	4.73E-16	1.54E-15	8	S234T	missense
M	235	R	39.30264859	-4.455836569	9.05E-55	5.24E-54	8	M235R	missense
M	235	I	553.0776436	-0.915205784	2.66E-69	1.63E-68	8	M235I	missense
M	235	K	240.3987982	-4.180949798	3.73E-87	2.95E-86	8	M235K	missense
M	235	T	601.8882374	-2.248891438	2.15E-147	2.37E-146	8	M235T	missense
M	235	V	612.2709513	-1.770925182	4.11E-100	3.52E-99	8	M235V	missense
F	236	C	40.75140296	-2.405683176	1.25E-37	5.93E-37	8	F236C	missense
F	236	I	1452.57073	0.816615837	2.58E-47	1.36E-46	8	F236I	missense
F	236	L	2771.057738	0.499754462	6.61E-33	2.85E-32	8	F236L	missense
F	236	S	622.7458636	-2.97259587	3.48E-160	4.27E-159	8	F236S	missense
F	236	Y	950.4687236	0.372561338	3.93E-14	1.25E-13	8	F236Y	missense
F	236	V	107.1334417	-0.547081063	1.85E-08	5.27E-08	8	F236V	missense
I	237	N	213.2281989	-3.837610061	3.01E-117	2.85E-116	8	I237N	missense
I	237	L	124.0866056	0.644405205	4.29E-12	1.31E-11	8	I237L	missense
I	237	M	44.93940736	-1.421067682	6.10E-23	2.19E-22	8	I237M	missense
I	237	F	305.9846467	-0.687327489	1.34E-24	5.02E-24	8	I237F	missense
I	237	S	31.86362278	-3.554505814	3.41E-46	1.78E-45	8	I237S	missense
I	237	T	565.9293043	-2.459680138	2.92E-120	2.86E-119	8	I237T	missense
I	237	V	1322.057912	0.47134591	1.67E-26	6.44E-26	8	I237V	missense
A	238	D	158.1967178	-3.516747553	5.36E-85	4.07E-84	8	A238D	missense
A	238	G	114.9624331	-0.665285942	7.62E-10	2.22E-09	8	A238G	missense
A	238	P	31.42125535	-2.864169826	1.46E-35	6.67E-35	8	A238P	missense
A	238	S	121.1470774	-0.731101532	1.25E-21	4.36E-21	8	A238S	missense
A	238	T	607.5065599	-0.668791395	9.31E-30	3.77E-29	8	A238T	missense
A	239	D	96.38389441	-2.214786066	6.25E-27	2.42E-26	8	A239D	missense
A	239	G	73.80861834	-1.043648308	3.54E-22	1.25E-21	8	A239G	missense
A	239	P	26.45103568	-1.560793841	1.66E-17	5.48E-17	8	A239P	missense
A	239	S	166.276225	0.25573358	4.20E-04	0.001025037	8	A239S	missense
A	239	T	533.3238409	-0.209905531	0.004377682	0.010214591	8	A239T	missense
A	239	V	866.5080445	0.588908079	2.90E-53	1.63E-52	8	A239V	missense
P	240	H	185.7187883	-1.967724113	1.10E-31	4.61E-31	8	P240H	missense
P	240	L	200.5762532	-1.589220005	1.56E-51	8.51E-51	8	P240L	missense
P	240	S	302.7418983	-1.027694682	8.24E-71	5.16E-70	8	P240S	missense
P	240	T	133.5657712	-1.149164479	1.65E-23	6.03E-23	8	P240T	missense
Y	241	R	10.10031075	1.906559057	8.58E-07	2.32E-06	8	Y241R	missense
Y	241	N	956.39416	1.4259403	9.07E-72	5.82E-71	8	Y241N	missense
Y	241	D	63.39246101	0.449513944	2.28E-05	5.85E-05	8	Y241D	missense
Y	241	C	1596.940341	1.300071941	1.08E-74	7.26E-74	8	Y241C	missense
Y	241	H	2930.917187	1.765648776	2.25E-114	2.09E-113	8	Y241H	missense
Y	241	F	688.9942324	1.070000433	3.71E-165	6.45E-164	8	Y241F	missense
Y	241	S	94.34767549	1.595799871	6.44E-37	3.02E-36	8	Y241S	missense
E	242	A	66.94815589	0.308232352	0.005284272	0.012224132	8	E242A	missense
E	242	D	1084.567784	0.952097155	3.33E-60	1.97E-59	8	E242D	missense
E	242	G	1274.748694	0.168109496	4.87E-06	1.27E-05	8	E242G	missense
E	242	K	370.4465156	0.873216269	4.28E-23	1.55E-22	8	E242K	missense
K	243	R	857.4001963	0.392389909	8.90E-19	3.39E-18	9	K243R	missense
K	243	N	382.161113	-0.504276299	1.09E-33	5.03E-33	9	K243N	missense
K	243	E	925.866875	-0.618153452	6.44E-27	2.65E-26	9	K243E	missense
K	243	Q	123.263474	-0.264152758	0.001191753	0.003195716	9	K243Q	missense
K	243	I	416.1693629	-0.342999465	2.90E-13	1.03E-12	9	K243I	missense
K	243	T	137.2537059	-0.430802161	4.92E-09	1.62E-08	9	K243T	missense
E	244	D	426.2991259	0.666121849	1.29E-44	6.64E-44	9	E244D	missense
E	244	G	1190.679555	0.429732354	1.73E-45	9.09E-45	9	E244G	missense
E	244	K	333.3050918	0.391334897	2.04E-08	6.47E-08	9	E244K	missense
E	244	V	349.2886569	-0.46936283	4.78E-30	2.07E-29	9	E244V	missense
V	245	A	1685.270961	0.109463654	0.008928198	0.021786513	9	V245A	missense
V	245	E	624.0317141	-0.105360888	0.017364325	0.04043747	9	V245E	missense
V	245	G	61.37292499	-0.407842129	1.55E-05	4.49E-05	9	V245G	missense
V	245	M	403.875255	-0.479018276	4.13E-14	1.50E-13	9	V245M	missense
P	246	R	30.65297464	-0.7734032	2.34E-07	7.33E-07	9	P246R	missense
P	246	L	297.556339	-1.588832391	1.25E-155	4.57E-154	9	P246L	missense
P	246	S	776.5937993	-0.140703544	8.46E-05	2.35E-04	9	P246S	missense
P	246	T	107.6956494	-0.538831941	5.16E-08	1.62E-07	9	P246T	missense
L	247	R	33.04926537	-3.700107945	2.90E-69	1.78E-68	9	L247R	missense
L	247	H	422.9865629	-2.441743396	1.45E-143	3.69E-142	9	L247H	missense
L	247	I	220.7444842	0.277878391	0.001196827	0.003195716	9	L247I	missense
L	247	F	205.5567394	-1.389928763	5.56E-88	3.88E-87	9	L247F	missense
L	247	P	996.0731817	-1.21770489	2.70E-116	4.92E-115	9	L247P	missense
S	248	C	20.94826512	-0.5220151	0.004980414	0.012451036	9	S248C	missense
S	248	F	383.0096809	-0.520913095	3.96E-18	1.50E-17	9	S248F	missense
S	248	P	652.3925332	-1.393865577	2.02E-43	1.02E-42	9	S248P	missense
S	248	T	736.9717502	0.293488114	8.40E-15	3.08E-14	9	S248T	missense
S	248	Y	375.3860147	-0.223475767	1.17E-06	3.50E-06	9	S248Y	missense
A	249	D	455.289504	0.460305486	4.72E-18	1.77E-17	9	A249D	missense
A	249	G	172.1662224	0.363194644	2.83E-07	8.74E-07	9	A249G	missense
A	249	P	90.41765685	0.38080433	1.67E-05	4.81E-05	9	A249P	missense
A	249	S	378.8840596	0.681926219	2.46E-53	1.41E-52	9	A249S	missense
A	249	T	1445.444724	0.718539034	3.74E-59	2.19E-58	9	A249T	missense
A	249	V	1278.067367	0.261889043	1.28E-09	4.29E-09	9	A249V	missense
L	250	R	43.12886786	-4.025472923	1.95E-87	1.35E-86	9	L250R	missense
L	250	H	434.3557798	-3.52588116	2.16E-176	1.00E-174	9	L250H	missense
L	250	I	702.351675	0.609568051	3.25E-19	1.27E-18	9	L250I	missense
L	250	F	298.2834174	-1.786253227	2.69E-209	1.53E-207	9	L250F	missense
L	250	P	610.8210983	-3.512777623	3.11E-117	5.87E-116	9	L250P	missense
L	250	V	78.03480277	0.43674765	0.001907951	0.005015748	9	L250V	missense
T	251	A	1098.629838	-0.765660865	6.40E-76	4.13E-75	9	T251A	missense
T	251	N	70.03052141	-0.434202274	6.61E-04	0.001801587	9	T251N	missense
T	251	I	1129.238086	0.630578943	2.11E-55	1.23E-54	9	T251I	missense
T	251	P	68.35329201	-2.850897235	2.50E-22	9.90E-22	9	T251P	missense
T	251	S	602.4476104	-0.437336334	4.94E-27	2.05E-26	9	T251S	missense
N	252	D	1863.031514	0.306401697	7.82E-12	2.70E-11	9	N252D	missense
N	252	H	113.2139153	-0.391515835	1.86E-05	5.33E-05	9	N252H	missense
N	252	I	470.9308911	-1.818936929	3.68E-127	7.50E-126	9	N252I	missense
N	252	K	231.7602223	0.343528486	2.56E-06	7.60E-06	9	N252K	missense
N	252	S	1983.186185	0.306308243	2.46E-14	8.97E-14	9	N252S	missense
N	252	Y	509.6204369	-1.356346538	4.73E-280	3.45E-278	9	N252Y	missense
I	253	N	419.4892167	-0.136637002	0.009953172	0.024057429	9	I253N	missense
I	253	F	362.1921204	-0.543450543	7.50E-33	3.38E-32	9	I253F	missense
I	253	V	949.6991318	0.188703576	2.58E-07	8.03E-07	9	I253V	missense
L	254	R	74.08153107	-4.005597582	5.64E-125	1.11E-123	9	L254R	missense
L	254	Q	433.4635259	-3.250554863	1.71E-239	1.09E-237	9	L254Q	missense
L	254	M	418.8568921	0.485483164	8.81E-19	3.38E-18	9	L254M	missense
L	254	P	721.3256587	-3.214431462	1.34E-280	1.14E-278	9	L254P	missense
L	254	V	103.3255238	0.676392705	1.31E-11	4.48E-11	9	L254V	missense
S	255	R	413.3604368	-1.656586066	8.33E-108	1.18E-106	9	S255R	missense
S	255	N	477.8660149	0.145262795	2.10E-04	5.79E-04	9	S255N	missense
S	255	C	483.0530096	-1.08421543	4.64E-169	1.97E-167	9	S255C	missense
S	255	G	731.0365793	-1.354267541	0	0	9	S255G	missense
S	255	I	96.52861621	-2.89381217	2.98E-147	8.95E-146	9	S255I	missense
S	255	T	24.43320437	0.439695195	0.017207823	0.040288494	9	S255T	missense
A	256	P	73.45568734	0.577385822	6.88E-09	2.19E-08	9	A256P	missense
A	256	S	172.200754	0.215214069	0.011043065	0.026441141	9	A256S	missense
A	256	T	1269.348253	0.761897465	8.65E-41	4.28E-40	9	A256T	missense
A	256	V	1804.834877	0.477196002	5.68E-26	2.26E-25	9	A256V	missense
Q	257	R	1666.340484	0.322277284	2.54E-26	1.03E-25	9	Q257R	missense
Q	257	E	120.0594792	0.817436884	2.85E-28	1.19E-27	9	Q257E	missense
Q	257	L	434.7129035	-1.746154994	1.91E-111	3.25E-110	9	Q257L	missense
Q	257	K	275.7563704	0.1929953	0.01415963	0.03343246	9	Q257K	missense
Q	257	P	119.5682976	-0.309640553	6.76E-05	1.88E-04	9	Q257P	missense
L	258	R	46.85572006	-1.625248595	8.27E-38	3.91E-37	9	L258R	missense
L	258	H	540.8428033	-1.229912806	5.76E-80	3.87E-79	9	L258H	missense
L	258	I	179.2261708	-0.27249915	8.55E-07	2.58E-06	9	L258I	missense
L	258	F	364.7492678	-1.734515504	3.95E-155	1.34E-153	9	L258F	missense
L	258	P	619.9357917	-3.147729918	8.20E-102	6.33E-101	9	L258P	missense
L	258	V	77.73878699	-0.291138886	4.78E-04	0.001309781	9	L258V	missense
I	259	N	296.272598	-3.805713068	3.25E-47	1.75E-46	9	I259N	missense
I	259	L	77.98988132	-0.362568944	2.86E-05	8.14E-05	9	I259L	missense
I	259	M	35.03379059	-0.702501416	5.64E-07	1.73E-06	9	I259M	missense
I	259	F	346.962886	-0.399956979	2.25E-15	8.32E-15	9	I259F	missense
I	259	S	34.53934143	-3.513248899	4.46E-74	2.84E-73	9	I259S	missense
I	259	T	614.0291181	-2.222665727	8.53E-182	4.35E-180	9	I259T	missense
S	260	R	614.3313154	-0.272134295	2.65E-09	8.77E-09	9	S260R	missense
S	260	N	1242.296907	0.58912268	3.88E-44	1.98E-43	9	S260N	missense
S	260	C	1057.948177	-0.18290313	6.91E-10	2.33E-09	9	S260C	missense
S	260	G	1793.853742	0.209582571	6.60E-09	2.12E-08	9	S260G	missense
S	260	I	222.4441556	-0.953306236	1.92E-28	8.11E-28	9	S260I	missense
S	260	T	68.78760615	0.44025462	0.002551623	0.006605725	9	S260T	missense
H	261	R	1810.502217	0.601993173	9.06E-49	4.91E-48	9	H261R	missense
H	261	N	930.5237918	0.686068422	8.73E-63	5.18E-62	9	H261N	missense
H	261	D	188.5529129	1.191151674	1.82E-64	1.11E-63	9	H261D	missense
H	261	Q	483.9338429	0.975702584	4.75E-53	2.69E-52	9	H261Q	missense
H	261	L	1436.581978	0.330801364	6.13E-13	2.17E-12	9	H261L	missense
H	261	P	88.26178501	-3.93721084	1.82E-144	5.15E-143	9	H261P	missense
H	261	Y	767.8278773	0.252171183	6.07E-09	1.97E-08	9	H261Y	missense
W	262	R	1116.355577	-3.6765087	1.49E-152	4.75E-151	9	W262R	missense
W	262	C	113.305468	-2.156815992	2.08E-50	1.16E-49	9	W262C	missense
W	262	G	66.57676171	-3.737462629	1.38E-78	9.14E-78	9	W262G	missense
W	262	L	245.8422156	-1.207866376	8.47E-39	4.04E-38	9	W262L	missense
W	262	S	17.46820908	-2.20848552	6.13E-21	2.41E-20	9	W262S	missense
K	263	R	1779.927857	0.114815615	7.84E-04	0.002116667	9	K263R	missense
K	263	N	650.5218701	-1.007843228	1.12E-135	2.72E-134	9	K263N	missense
K	263	E	1539.472722	-0.368291919	1.41E-31	6.31E-31	9	K263E	missense
K	263	I	570.4381726	-0.222945972	5.96E-06	1.74E-05	9	K263I	missense
K	263	T	99.03647791	-0.421061032	5.78E-07	1.77E-06	9	K263T	missense
G	264	A	76.41263684	1.062609134	1.09E-28	4.64E-28	9	G264A	missense
G	264	R	48.99551261	0.975332254	5.22E-12	1.81E-11	9	G264R	missense
G	264	D	1081.303649	0.923762283	2.99E-131	6.36E-130	9	G264D	missense
G	264	C	368.4038916	0.284862717	1.48E-09	4.93E-09	9	G264C	missense
G	264	S	587.5004848	0.757058346	5.25E-97	3.82E-96	9	G264S	missense
G	264	V	209.9272953	0.509995207	7.78E-19	3.01E-18	9	G264V	missense
N	265	D	1469.676817	-0.37906726	7.01E-31	3.05E-30	9	N265D	missense
N	265	H	127.6132954	0.318953499	4.86E-05	1.36E-04	9	N265H	missense
N	265	I	851.2627046	-0.636397562	3.59E-80	2.44E-79	9	N265I	missense
N	265	K	331.5895681	0.749137337	1.16E-26	4.74E-26	9	N265K	missense
N	265	S	2043.949793	0.481024649	2.24E-31	9.93E-31	9	N265S	missense
N	265	T	127.6793892	0.168473411	0.012645641	0.030136809	9	N265T	missense
N	265	Y	687.1958077	-0.928099137	9.03E-144	2.42E-142	9	N265Y	missense
M	266	R	45.34228116	-1.975416003	1.79E-45	9.33E-45	9	M266R	missense
M	266	I	374.7193292	-1.440263129	2.41E-73	1.52E-72	9	M266I	missense
M	266	L	377.2142014	-1.285136007	2.20E-131	5.10E-130	9	M266L	missense
M	266	K	279.5733357	-1.711167489	1.21E-100	9.19E-100	9	M266K	missense
M	266	T	845.147294	-1.373762524	6.76E-109	1.05E-107	9	M266T	missense
M	266	V	670.7723326	-1.324175326	1.90E-302	1.93E-300	9	M266V	missense
T	267	A	1252.627976	-0.093507278	0.007088861	0.017381342	9	T267A	missense
T	267	I	949.8174454	0.220212314	5.08E-14	1.82E-13	9	T267I	missense
T	267	P	38.78690706	-1.827639782	3.84E-40	1.88E-39	9	T267P	missense
T	267	S	787.5355076	0.181820821	4.42E-06	1.29E-05	9	T267S	missense
R	268	K	711.9435481	0.726039448	6.63E-46	3.52E-45	9	R268K	missense
R	268	M	854.7519733	0.811888475	1.21E-96	8.72E-96	9	R268M	missense
R	268	S	383.2576493	0.638451267	2.25E-29	9.64E-29	9	R268S	missense
R	268	W	655.1003889	-0.458889747	1.87E-33	8.51E-33	9	R268W	missense
L	269	R	108.9194481	0.391574141	2.60E-06	7.67E-06	9	L269R	missense
L	269	Q	987.4738077	0.829948319	2.35E-94	1.66E-93	9	L269Q	missense
L	269	M	232.3069403	0.3029695	5.76E-09	1.88E-08	9	L269M	missense
L	269	P	851.7446475	-1.62437254	6.05E-53	3.39E-52	9	L269P	missense
L	269	V	244.5863839	1.10554001	8.83E-64	5.30E-63	9	L269V	missense
P	270	H	489.5461217	0.562825941	4.89E-37	2.29E-36	9	P270H	missense
P	270	L	1018.502873	-0.15401847	0.004094332	0.010286252	9	P270L	missense
P	270	T	241.8273112	0.528448676	3.62E-05	1.02E-04	9	P270T	missense
R	271	C	3543.92482	0.541045814	1.56E-12	5.49E-12	9	R271C	missense
R	271	H	709.0743928	-0.849823752	1.79E-98	1.32E-97	9	R271H	missense
R	271	L	1292.057535	0.788870929	1.73E-15	6.46E-15	9	R271L	missense
R	271	P	40.68917772	-2.884131738	1.41E-70	8.77E-70	9	R271P	missense
R	271	S	499.0528652	-0.712887521	3.16E-31	1.39E-30	9	R271S	missense
L	272	R	228.5077165	1.362838645	1.34E-39	6.45E-39	9	L272R	missense
L	272	H	1027.870028	0.806821042	1.43E-42	7.13E-42	9	L272H	missense
L	272	I	381.4509265	0.467412648	6.06E-11	2.06E-10	9	L272I	missense
L	272	P	597.4179847	-3.140738715	7.08E-99	5.31E-98	9	L272P	missense
L	272	V	39.09008087	0.41871162	0.00258616	0.006661321	9	L272V	missense
L	273	R	56.55407197	-4.078101415	3.04E-113	5.34E-112	9	L273R	missense
L	273	Q	336.1620353	-4.13655165	2.41E-131	5.33E-130	9	L273Q	missense
L	273	M	259.8689063	-1.690094918	1.48E-78	9.65E-78	9	L273M	missense
L	273	P	595.2080726	-3.507971807	1.68E-156	6.59E-155	9	L273P	missense
L	273	V	55.44342713	0.727560694	2.14E-12	7.47E-12	9	L273V	missense
V	274	A	795.4073057	-1.259791784	7.17E-40	3.48E-39	9	V274A	missense
V	274	D	236.8366907	-3.858714157	7.20E-102	5.65E-101	9	V274D	missense
V	274	G	19.88081943	-2.071720863	3.16E-26	1.27E-25	9	V274G	missense
V	274	I	979.8978762	0.554623339	1.15E-36	5.35E-36	9	V274I	missense
V	274	L	52.00833602	-0.549913808	9.37E-07	2.81E-06	9	V274L	missense
V	274	F	98.35941988	-0.901554462	6.20E-09	2.00E-08	9	V274F	missense
L	275	R	43.52781551	-3.962625557	2.04E-47	1.10E-46	10	L275R	missense
L	275	Q	365.7688844	-3.51348773	5.44E-89	4.94E-88	10	L275Q	missense
L	275	M	515.789788	1.217888916	1.78E-74	1.36E-73	10	L275M	missense
L	275	P	623.4350611	-3.509409279	1.00E-142	4.19E-141	10	L275P	missense
P	276	A	46.58838904	-1.830821686	1.38E-17	4.69E-17	10	P276A	missense
P	276	R	39.18968356	-2.867174353	2.80E-53	1.66E-52	10	P276R	missense
P	276	H	290.9442945	-3.604671041	1.58E-45	8.11E-45	10	P276H	missense
P	276	L	306.7022016	-3.081503121	2.34E-86	2.08E-85	10	P276L	missense
P	276	S	302.4326239	-2.906333813	1.05E-135	4.07E-134	10	P276S	missense
P	276	T	125.1784765	-1.531847262	8.03E-05	2.09E-04	10	P276T	missense
K	277	R	1124.686428	0.366613855	5.43E-14	1.77E-13	10	K277R	missense
K	277	N	79.89651997	-0.992815361	6.47E-17	2.19E-16	10	K277N	missense
K	277	E	618.3219793	-1.430029788	2.13E-158	1.16E-156	10	K277E	missense
K	277	Q	102.9901674	-0.481797474	1.50E-08	4.29E-08	10	K277Q	missense
K	277	M	509.116224	-0.639834711	1.15E-11	3.60E-11	10	K277M	missense
K	277	T	67.52142218	-0.453664967	2.55E-05	6.79E-05	10	K277T	missense
F	278	C	19.70641053	-1.928692706	2.29E-18	7.99E-18	10	F278C	missense
F	278	I	211.0289655	-0.876756514	1.17E-07	3.30E-07	10	F278I	missense
F	278	S	464.2233978	-2.692232208	5.54E-48	3.04E-47	10	F278S	missense
F	278	Y	188.9949838	-1.235818545	1.65E-70	1.13E-69	10	F278Y	missense
F	278	V	29.35721163	-1.218968684	3.50E-10	1.04E-09	10	F278V	missense
S	279	A	57.50504034	0.425228792	0.018135641	0.042524952	10	S279A	missense
S	279	C	46.69626357	0.942315024	4.90E-12	1.54E-11	10	S279C	missense
S	279	F	224.8908896	-0.867417728	1.06E-43	5.17E-43	10	S279F	missense
S	279	P	736.436367	-2.247320608	0	0	10	S279P	missense
S	279	T	1127.762162	1.222950435	1.28E-53	7.76E-53	10	S279T	missense
S	279	Y	125.6372655	-0.523188165	5.66E-04	0.001438963	10	S279Y	missense
L	280	R	48.37206172	-3.184931043	1.32E-42	6.38E-42	10	L280R	missense
L	280	Q	591.0277012	-1.003520235	2.39E-51	1.39E-50	10	L280Q	missense
L	280	M	1289.396697	0.972041925	1.75E-46	9.06E-46	10	L280M	missense
L	280	P	684.7925871	-2.314504716	0	0	10	L280P	missense
L	280	V	113.7964678	0.631331081	2.43E-11	7.41E-11	10	L280V	missense
E	281	A	42.64457691	-0.688233385	8.75E-09	2.55E-08	10	E281A	missense
E	281	D	193.3757935	-0.483394959	3.57E-13	1.14E-12	10	E281D	missense
E	281	G	654.9135276	-1.581312602	2.47E-39	1.12E-38	10	E281G	missense
E	281	K	235.5496623	-1.636026077	1.74E-80	1.50E-79	10	E281K	missense
T	282	A	928.4906723	0.239629135	5.54E-08	1.57E-07	10	T282A	missense
T	282	N	142.2361647	0.562421921	2.95E-09	8.66E-09	10	T282N	missense
T	282	I	407.7738438	-0.480270504	2.04E-18	7.16E-18	10	T282I	missense
T	282	P	27.79796259	-2.759246598	3.78E-36	1.65E-35	10	T282P	missense
T	282	S	955.0667799	1.053460571	1.92E-74	1.45E-73	10	T282S	missense
E	283	A	148.7103505	1.133083762	3.44E-21	1.27E-20	10	E283A	missense
E	283	D	811.2489099	0.271153843	4.95E-06	1.36E-05	10	E283D	missense
E	283	Q	20.77287913	0.816917169	3.44E-04	8.84E-04	10	E283Q	missense
E	283	K	658.0561322	0.776942838	9.38E-21	3.43E-20	10	E283K	missense
E	283	V	1307.892191	1.127255974	4.42E-80	3.70E-79	10	E283V	missense
V	284	A	713.4501351	-0.60283563	1.44E-48	7.97E-48	10	V284A	missense
V	284	D	240.9537852	-2.774123305	8.54E-43	4.15E-42	10	V284D	missense
V	284	G	36.46273631	-2.553605456	1.14E-44	5.77E-44	10	V284G	missense
V	284	I	431.8425044	1.120610836	7.16E-73	5.20E-72	10	V284I	missense
V	284	F	113.8228789	-0.722048209	6.50E-14	2.09E-13	10	V284F	missense
D	285	A	33.42657124	-1.478919594	2.78E-18	9.64E-18	10	D285A	missense
D	285	N	1097.059645	0.594595442	3.77E-31	1.55E-30	10	D285N	missense
D	285	E	138.5290617	-0.513326623	1.53E-11	4.72E-11	10	D285E	missense
D	285	G	524.190574	-1.871335319	5.74E-110	5.68E-109	10	D285G	missense
D	285	H	18.99065527	-0.90529279	4.20E-06	1.16E-05	10	D285H	missense
D	285	Y	124.4884478	-1.070591989	4.99E-23	1.88E-22	10	D285Y	missense
D	285	V	244.9048425	-1.593444136	1.65E-44	8.24E-44	10	D285V	missense
L	286	R	34.20529611	-3.580641599	6.48E-53	3.79E-52	10	L286R	missense
L	286	H	337.0528679	-3.907189675	1.83E-80	1.55E-79	10	L286H	missense
L	286	I	293.1698364	-1.348195817	5.55E-65	3.73E-64	10	L286I	missense
L	286	F	259.7750227	-1.629151396	2.60E-97	2.48E-96	10	L286F	missense
L	286	P	616.8160299	-3.197936774	1.80E-73	1.34E-72	10	L286P	missense
L	286	V	49.15760227	-2.07806654	1.11E-49	6.23E-49	10	L286V	missense
R	287	G	702.1562627	-1.373699851	3.39E-219	3.07E-217	10	R287G	missense
R	287	K	422.725222	0.670829127	2.35E-21	8.68E-21	10	R287K	missense
R	287	M	320.9493334	-0.255706093	0.013091124	0.031098565	10	R287M	missense
R	287	S	75.49755157	-0.352948407	0.003954838	0.009604605	10	R287S	missense
R	287	W	323.1876934	-1.443082065	5.01E-62	3.33E-61	10	R287W	missense
K	288	R	1995.585437	0.769723363	1.33E-40	6.12E-40	10	K288R	missense
K	288	N	271.7588853	0.261198324	9.55E-06	2.57E-05	10	K288N	missense
K	288	E	1778.957832	0.792396555	1.15E-40	5.37E-40	10	K288E	missense
K	288	Q	79.02840173	0.89176427	1.28E-11	3.98E-11	10	K288Q	missense
K	288	M	669.2611608	0.578275679	5.71E-22	2.13E-21	10	K288M	missense
K	288	T	211.1223122	0.684817741	1.46E-16	4.80E-16	10	K288T	missense
P	289	R	14.43292543	-0.860743423	0.002936674	0.007196175	10	P289R	missense
P	289	S	460.8053439	-0.2562955	1.35E-08	3.88E-08	10	P289S	missense
L	290	R	21.55020406	-3.480603798	1.96E-31	8.13E-31	10	L290R	missense
L	290	Q	250.6731759	-3.342591195	3.60E-72	2.51E-71	10	L290Q	missense
L	290	I	178.6218509	-1.012530922	1.05E-50	6.00E-50	10	L290I	missense
L	290	P	492.0185702	-3.289360898	4.37E-78	3.45E-77	10	L290P	missense
L	290	V	19.53986336	-1.174083497	1.16E-08	3.36E-08	10	L290V	missense
E	291	D	111.3526955	-1.105153855	5.80E-20	2.11E-19	10	E291D	missense
E	291	G	727.7303369	-0.634161237	3.30E-29	1.35E-28	10	E291G	missense
E	291	K	186.9119928	-0.383515284	1.06E-06	2.95E-06	10	E291K	missense
E	291	V	311.6975486	-0.43308335	3.87E-12	1.22E-11	10	E291V	missense
N	292	D	1376.037746	0.503864159	1.53E-19	5.47E-19	10	N292D	missense
N	292	H	62.69271689	0.460979826	3.72E-04	9.50E-04	10	N292H	missense
N	292	K	191.1520189	0.904688688	8.96E-41	4.20E-40	10	N292K	missense
N	292	S	1756.602335	0.784059788	1.91E-50	1.08E-49	10	N292S	missense
N	292	T	47.16046852	0.527140254	2.02E-05	5.42E-05	10	N292T	missense
L	293	R	48.30570719	-2.356705094	2.18E-38	9.71E-38	10	L293R	missense
L	293	Q	379.4372847	-1.684286964	1.37E-228	1.87E-226	10	L293Q	missense
L	293	M	443.5924326	0.791560285	1.07E-34	4.64E-34	10	L293M	missense
L	293	P	478.5015737	-3.053031247	1.06E-113	1.07E-112	10	L293P	missense
L	293	V	24.49688275	-0.711385627	8.08E-05	2.09E-04	10	L293V	missense
G	294	R	323.4489031	-1.468981779	3.58E-143	1.62E-141	10	G294R	missense
G	294	E	197.9072347	-1.435143576	1.10E-103	1.07E-102	10	G294E	missense
M	295	R	22.48217331	-3.236041481	6.48E-29	2.63E-28	10	M295R	missense
M	295	I	751.6191442	0.852439923	4.65E-60	3.05E-59	10	M295I	missense
M	295	L	365.6874075	0.319712559	6.66E-07	1.87E-06	10	M295L	missense
M	295	K	114.8946415	-3.496181012	2.34E-59	1.50E-58	10	M295K	missense
M	295	T	432.6505174	-1.725691978	1.79E-93	1.68E-92	10	M295T	missense
M	295	V	1549.057004	0.645565774	2.34E-41	1.12E-40	10	M295V	missense
T	296	A	1188.312516	0.163157202	8.96E-05	2.31E-04	10	T296A	missense
T	296	I	651.6109846	0.570702498	1.92E-31	8.03E-31	10	T296I	missense
T	296	S	826.0734919	0.266488055	3.95E-11	1.20E-10	10	T296S	missense
D	297	A	162.9935891	0.579379961	7.33E-17	2.46E-16	10	D297A	missense
D	297	N	1213.59051	1.108206123	4.80E-79	3.90E-78	10	D297N	missense
D	297	G	1150.965596	-0.157783321	6.13E-04	0.001550109	10	D297G	missense
D	297	H	50.77280905	0.994934222	7.38E-17	2.46E-16	10	D297H	missense
D	297	Y	391.8525868	0.738544143	4.33E-23	1.66E-22	10	D297Y	missense
D	297	V	731.5291817	-0.794320817	4.43E-123	4.64E-122	10	D297V	missense
M	298	R	25.71442045	-3.800080681	1.83E-36	8.04E-36	10	M298R	missense
M	298	I	555.774465	0.327823285	8.27E-11	2.49E-10	10	M298I	missense
M	298	L	547.0819425	0.27544708	3.85E-05	1.02E-04	10	M298L	missense
M	298	K	156.5725792	-3.219026163	1.02E-79	8.43E-79	10	M298K	missense
M	298	T	455.8337405	-1.289997816	2.99E-126	9.56E-125	10	M298T	missense
F	299	C	33.36953801	-3.240168464	1.96E-53	1.17E-52	10	F299C	missense
F	299	I	348.2100909	-2.171980861	4.49E-172	3.06E-170	10	F299I	missense
F	299	L	935.3360867	-1.366376411	1.04E-46	5.49E-46	10	F299L	missense
F	299	S	617.1615886	-1.907778602	1.23E-54	7.52E-54	10	F299S	missense
F	299	Y	480.953543	-1.511036662	3.60E-164	2.18E-162	10	F299Y	missense
F	299	V	44.45244652	-2.460717644	1.61E-45	8.18E-45	10	F299V	missense
R	300	G	1214.857888	-0.215973541	7.57E-09	2.21E-08	10	R300G	missense
R	300	I	321.5626409	0.744789035	5.16E-37	2.28E-36	10	R300I	missense
R	300	K	522.0800529	1.158901124	1.74E-70	1.18E-69	10	R300K	missense
R	300	S	794.6855391	1.030167428	7.04E-79	5.63E-78	10	R300S	missense
R	300	T	47.14295847	0.899991296	2.37E-10	7.08E-10	10	R300T	missense
Q	301	R	1554.428701	0.910237012	2.25E-72	1.59E-71	10	Q301R	missense
Q	301	E	254.3618261	1.017142089	6.67E-26	2.65E-25	10	Q301E	missense
Q	301	H	153.5831543	0.48179221	5.72E-10	1.69E-09	10	Q301H	missense
Q	301	L	738.987155	0.336476745	2.54E-13	8.13E-13	10	Q301L	missense
Q	301	K	170.4213673	1.195649822	1.96E-47	1.07E-46	10	Q301K	missense
Q	301	P	211.3732916	1.573564339	1.26E-59	8.18E-59	10	Q301P	missense
F	302	C	81.69526545	0.674721024	7.29E-11	2.20E-10	10	F302C	missense
F	302	L	2155.895735	0.500462156	2.28E-32	9.63E-32	10	F302L	missense
F	302	S	2103.697918	1.158801705	9.33E-91	8.60E-90	10	F302S	missense
F	302	Y	729.618087	1.084323292	8.27E-55	5.11E-54	10	F302Y	missense
F	302	V	71.74274832	0.252282708	0.018464265	0.042925471	10	F302V	missense
Q	303	R	2022.549762	0.898170969	2.62E-56	1.64E-55	10	Q303R	missense
Q	303	E	24.50062901	1.214607383	2.13E-08	6.06E-08	10	Q303E	missense
Q	303	H	777.837622	0.757607654	1.52E-46	7.97E-46	10	Q303H	missense
Q	303	L	660.6439185	0.37047792	1.09E-17	3.74E-17	10	Q303L	missense
Q	303	K	200.9424695	1.458781255	5.58E-57	3.53E-56	10	Q303K	missense
Q	303	P	59.7068127	-1.232545594	1.41E-19	5.09E-19	10	Q303P	missense
A	304	D	157.530406	-1.080715943	4.80E-23	1.82E-22	10	A304D	missense
A	304	P	37.79372636	-0.693671006	5.49E-06	1.50E-05	10	A304P	missense
A	304	S	183.9472629	-0.29689497	6.40E-05	1.69E-04	10	A304S	missense
A	304	T	324.7016266	-0.69329387	4.60E-24	1.77E-23	10	A304T	missense
A	304	V	341.7333147	-1.058202212	7.17E-28	2.87E-27	10	A304V	missense
D	305	A	42.997795	-0.656781697	6.99E-06	1.89E-05	10	D305A	missense
D	305	N	577.5567801	0.797448119	3.95E-34	1.68E-33	10	D305N	missense
D	305	E	88.35977359	-0.447085156	3.53E-06	9.80E-06	10	D305E	missense
D	305	G	542.753952	-0.968235015	1.25E-34	5.36E-34	10	D305G	missense
D	305	Y	85.49075391	-0.761782136	5.51E-14	1.79E-13	10	D305Y	missense
D	305	V	292.0144762	-0.908754958	2.36E-15	7.73E-15	10	D305V	missense
F	306	C	26.75904235	-2.129327516	1.27E-25	5.01E-25	10	F306C	missense
F	306	I	413.9343303	-0.882896508	3.09E-25	1.20E-24	10	F306I	missense
F	306	L	1081.313215	-0.347774743	3.30E-18	1.14E-17	10	F306L	missense
F	306	S	626.7117696	-1.60096404	1.33E-25	5.21E-25	10	F306S	missense
F	306	Y	383.9216813	-1.184441793	1.59E-40	7.25E-40	10	F306Y	missense
F	306	V	45.61396764	-1.229563037	1.51E-18	5.34E-18	10	F306V	missense
T	307	A	1191.739965	-0.393192185	6.22E-41	2.94E-40	10	T307A	missense
T	307	R	98.2256766	0.285287166	0.00110186	0.002762266	10	T307R	missense
T	307	M	759.6222555	-0.530275096	6.16E-44	3.04E-43	10	T307M	missense
T	307	P	67.89907881	-1.128380609	8.20E-17	2.72E-16	10	T307P	missense
T	307	S	981.5510142	1.086190095	2.09E-129	7.09E-128	10	T307S	missense
S	308	R	1025.187918	1.306852953	2.01E-154	9.94E-153	10	S308R	missense
S	308	N	613.4182359	1.202822878	2.09E-72	1.50E-71	10	S308N	missense
S	308	C	1020.470645	0.144236542	0.002559666	0.006300717	10	S308C	missense
S	308	G	2206.890764	1.338292583	3.12E-73	2.29E-72	10	S308G	missense
S	308	I	122.6835264	-0.467453217	6.76E-06	1.84E-05	10	S308I	missense
L	309	R	44.59716229	-1.412820826	2.05E-11	6.29E-11	10	L309R	missense
L	309	H	239.4528239	-1.184102947	3.82E-28	1.54E-27	10	L309H	missense
L	309	I	98.89762407	0.381748135	6.70E-05	1.76E-04	10	L309I	missense
L	309	P	668.476911	-1.074161682	1.01E-22	3.80E-22	10	L309P	missense
S	310	L	243.9103099	-0.868821444	7.80E-43	4.22E-42	11	S310L	missense
S	310	P	784.376635	-1.512508263	2.24E-23	8.37E-23	11	S310P	missense
S	310	T	1308.460767	0.626329111	2.31E-34	1.03E-33	11	S310T	missense
D	311	A	81.85639523	0.492081854	5.88E-09	1.70E-08	11	D311A	missense
D	311	N	460.5356417	0.378625503	1.04E-11	3.19E-11	11	D311N	missense
D	311	E	473.5677232	0.74292862	1.07E-89	9.98E-89	11	D311E	missense
D	311	V	599.3383983	0.789789689	2.81E-97	2.86E-96	11	D311V	missense
Q	312	E	119.7474203	0.758494779	2.00E-23	7.51E-23	11	Q312E	missense
Q	312	H	931.7168576	0.345747221	7.09E-22	2.50E-21	11	Q312H	missense
Q	312	L	586.6926564	-0.248148223	4.44E-11	1.34E-10	11	Q312L	missense
Q	312	K	314.8229849	0.270004584	8.32E-06	2.19E-05	11	Q312K	missense
Q	312	P	86.8707084	-1.104350096	5.37E-39	2.71E-38	11	Q312P	missense
E	313	G	1091.542729	0.185988122	6.86E-14	2.23E-13	11	E313G	missense
E	313	K	392.2068654	0.734715626	7.76E-41	4.03E-40	11	E313K	missense
E	313	V	480.3448751	0.268394433	1.78E-10	5.31E-10	11	E313V	missense
P	314	H	315.2299667	0.364209281	2.32E-07	6.57E-07	11	P314H	missense
P	314	L	349.3481708	-0.213553004	3.88E-06	1.03E-05	11	P314L	missense
L	315	R	54.29756789	-1.523680004	2.48E-39	1.26E-38	11	L315R	missense
L	315	H	742.3101397	-1.0825063	2.57E-24	9.88E-24	11	L315H	missense
L	315	I	182.6916411	0.871398	8.75E-32	3.77E-31	11	L315I	missense
L	315	F	303.776438	-0.745320158	1.11E-58	7.61E-58	11	L315F	missense
L	315	P	955.6518349	-1.3383158	2.86E-22	1.03E-21	11	L315P	missense
L	315	V	25.23218558	0.634182061	1.00E-04	2.58E-04	11	L315V	missense
H	316	R	1381.933918	-0.442622754	5.13E-27	2.06E-26	11	H316R	missense
H	316	N	345.670237	-0.212445014	1.67E-06	4.57E-06	11	H316N	missense
H	316	D	31.77506168	-1.297585775	2.39E-18	8.12E-18	11	H316D	missense
H	316	Q	204.9882878	-0.612901697	1.81E-16	5.99E-16	11	H316Q	missense
H	316	L	375.1749428	-1.524410349	8.46E-136	1.07E-134	11	H316L	missense
H	316	P	44.11531704	-4.014849919	5.42E-37	2.54E-36	11	H316P	missense
H	316	Y	592.3654615	0.222101761	4.19E-07	1.18E-06	11	H316Y	missense
V	317	A	976.6067686	-0.936585794	1.45E-74	1.18E-73	11	V317A	missense
V	317	D	407.0843792	-2.902450828	2.03E-58	1.38E-57	11	V317D	missense
V	317	G	66.77811842	-1.644715645	2.07E-59	1.44E-58	11	V317G	missense
V	317	I	839.6566011	0.192673964	1.93E-06	5.26E-06	11	V317I	missense
V	317	L	60.52062463	1.157887217	7.99E-28	3.26E-27	11	V317L	missense
V	317	F	78.75523218	-1.735851928	1.38E-34	6.24E-34	11	V317F	missense
A	318	E	103.6889898	-0.880332488	4.95E-23	1.82E-22	11	A318E	missense
A	318	G	56.84091707	0.648904086	6.00E-11	1.81E-10	11	A318G	missense
A	318	P	45.28373774	-2.178169223	6.19E-38	2.98E-37	11	A318P	missense
A	318	S	250.5965285	0.92592969	1.44E-44	7.97E-44	11	A318S	missense
A	318	V	751.1655437	-0.386803729	1.43E-13	4.59E-13	11	A318V	missense
Q	319	R	1677.7883	0.846351199	2.10E-87	1.85E-86	11	Q319R	missense
Q	319	E	45.00663979	-1.118434908	3.82E-18	1.29E-17	11	Q319E	missense
Q	319	H	302.4681186	0.154972996	8.18E-04	0.002015437	11	Q319H	missense
Q	319	L	1187.4172	0.464814283	4.70E-24	1.79E-23	11	Q319L	missense
Q	319	K	344.0006123	1.084821118	1.46E-59	1.03E-58	11	Q319K	missense
Q	319	P	57.46376245	-2.306688307	1.67E-14	5.47E-14	11	Q319P	missense
A	320	E	88.60310482	-2.643922642	6.07E-79	5.10E-78	11	A320E	missense
A	320	G	76.23233202	-1.683351416	5.15E-45	2.88E-44	11	A320G	missense
A	320	T	220.7216443	-1.730026516	3.41E-89	3.12E-88	11	A320T	missense
A	320	V	597.3760329	-0.687376948	7.24E-31	3.05E-30	11	A320V	missense
L	321	R	105.0011702	-0.47485054	2.89E-06	7.71E-06	11	L321R	missense
L	321	Q	488.9420392	-2.001040761	1.26E-117	1.42E-116	11	L321Q	missense
L	321	M	141.4785341	-0.380123822	3.20E-08	9.17E-08	11	L321M	missense
L	321	P	662.9822035	-2.938446003	1.03E-62	7.61E-62	11	L321P	missense
L	321	V	41.77630302	0.673487828	1.82E-05	4.76E-05	11	L321V	missense
Q	322	R	751.0343612	-3.7602555	8.59E-68	6.70E-67	11	Q322R	missense
Q	322	E	30.20913669	-1.413242487	2.06E-16	6.76E-16	11	Q322E	missense
Q	322	H	157.6765301	-1.250987647	8.55E-58	5.74E-57	11	Q322H	missense
Q	322	L	377.0278377	-3.058437885	2.42E-96	2.42E-95	11	Q322L	missense
Q	322	K	76.51411849	-2.309317676	3.75E-22	1.33E-21	11	Q322K	missense
Q	322	P	49.32470725	-4.135579871	6.54E-52	4.13E-51	11	Q322P	missense
K	323	R	1132.21908	-0.340700566	4.93E-12	1.53E-11	11	K323R	missense
K	323	N	493.1327071	-1.717123261	6.13E-124	7.38E-123	11	K323N	missense
K	323	E	541.9515776	-1.275678999	2.52E-32	1.10E-31	11	K323E	missense
K	323	Q	42.75085776	-1.08171808	1.39E-18	4.77E-18	11	K323Q	missense
K	323	I	531.8244827	-0.846836946	1.82E-133	2.25E-132	11	K323I	missense
K	323	T	61.06349249	-0.952494166	8.55E-21	2.96E-20	11	K323T	missense
V	324	A	1227.136137	-0.392609843	1.89E-22	6.90E-22	11	V324A	missense
V	324	E	244.2177596	-3.87119104	5.26E-88	4.72E-87	11	V324E	missense
V	324	G	55.57656396	-2.034155922	4.93E-68	3.90E-67	11	V324G	missense
V	324	L	88.1500396	-1.302996158	7.25E-22	2.54E-21	11	V324L	missense
V	324	M	191.52759	-1.973989795	1.17E-50	6.94E-50	11	V324M	missense
K	325	R	1704.161822	0.442084195	1.53E-48	8.82E-48	11	K325R	missense
K	325	N	96.66135897	-1.888498246	3.52E-57	2.33E-56	11	K325N	missense
K	325	E	852.4305305	-2.322114213	1.40E-76	1.16E-75	11	K325E	missense
K	325	Q	54.05188172	-1.344273165	2.67E-28	1.10E-27	11	K325Q	missense
K	325	M	431.7046188	-0.524225126	1.30E-41	6.85E-41	11	K325M	missense
K	325	T	55.11388093	-2.378639192	1.30E-51	8.00E-51	11	K325T	missense
I	326	N	228.32971	-3.758149212	1.16E-92	1.09E-91	11	I326N	missense
I	326	L	55.21403167	0.470778335	2.81E-06	7.53E-06	11	I326L	missense
I	326	F	495.0341819	0.623246856	3.34E-36	1.54E-35	11	I326F	missense
I	326	S	12.65772855	-3.658653515	1.22E-24	4.76E-24	11	I326S	missense
I	326	T	419.7905913	-2.117265784	9.35E-94	9.01E-93	11	I326T	missense
I	326	V	1293.307505	0.479287586	2.96E-31	1.26E-30	11	I326V	missense
E	327	A	52.02587115	-0.938069348	7.43E-18	2.49E-17	11	E327A	missense
E	327	D	401.7795065	0.448220596	2.70E-22	9.81E-22	11	E327D	missense
E	327	G	894.8824826	-1.343837646	4.40E-33	1.93E-32	11	E327G	missense
E	327	K	905.5538615	-0.333288582	2.81E-13	8.96E-13	11	E327K	missense
E	327	V	2319.946973	0.875002834	2.75E-63	2.05E-62	11	E327V	missense
V	328	A	1193.712036	-0.646310942	9.68E-41	4.98E-40	11	V328A	missense
V	328	E	326.1993	-2.301813508	1.70E-148	2.20E-147	11	V328E	missense
V	328	G	83.13690025	-1.520611091	1.68E-34	7.53E-34	11	V328G	missense
V	328	L	54.92644835	-0.692594889	1.11E-06	3.06E-06	11	V328L	missense
V	328	M	296.2685368	-0.747046127	1.11E-43	6.07E-43	11	V328M	missense
N	329	D	1527.288264	0.237142073	2.18E-06	5.90E-06	11	N329D	missense
N	329	H	113.3570481	0.342924594	5.28E-04	0.001326826	11	N329H	missense
N	329	I	463.928695	-0.693354456	1.06E-38	5.24E-38	11	N329I	missense
N	329	K	486.5645702	0.352909438	4.43E-09	1.30E-08	11	N329K	missense
N	329	S	2388.657796	0.519050638	5.24E-49	3.09E-48	11	N329S	missense
N	329	T	114.294083	0.535727733	1.37E-08	3.94E-08	11	N329T	missense
N	329	Y	456.4584785	-0.940344249	1.98E-122	2.34E-121	11	N329Y	missense
E	330	D	499.2413978	0.29345967	9.61E-04	0.002358808	11	E330D	missense
E	330	G	1615.435034	-0.209175861	2.08E-05	5.42E-05	11	E330G	missense
E	330	K	715.414031	-0.854637206	1.16E-41	6.16E-41	11	E330K	missense
E	330	V	712.343299	-0.776351795	3.51E-37	1.66E-36	11	E330V	missense
S	331	R	1113.611681	0.220606638	0.001568069	0.003829845	11	S331R	missense
S	331	N	320.24724	0.317009241	2.56E-06	6.89E-06	11	S331N	missense
S	331	C	425.8034099	-0.395045949	5.56E-12	1.71E-11	11	S331C	missense
S	331	G	5474.569705	1.295441754	4.42E-51	2.70E-50	11	S331G	missense
S	331	I	98.63030301	-1.164261945	8.84E-42	4.73E-41	11	S331I	missense
G	332	A	219.3825138	0.655467515	9.54E-07	2.65E-06	11	G332A	missense
G	332	R	38.13411111	0.840698691	2.64E-05	6.82E-05	11	G332R	missense
G	332	D	2750.313702	0.477908508	7.12E-07	2.00E-06	11	G332D	missense
G	332	S	2170.593762	0.809243271	4.88E-17	1.63E-16	11	G332S	missense
T	333	A	6598.458299	0.869528679	1.93E-27	7.79E-27	11	T333A	missense
T	333	R	39.65749788	-3.674141468	1.24E-37	5.92E-37	11	T333R	missense
T	333	K	69.36730352	-3.007319492	9.70E-37	4.51E-36	11	T333K	missense
T	333	M	2150.494031	0.206728097	0.002954264	0.007182386	11	T333M	missense
T	333	P	46.5594856	-3.94907573	1.84E-86	1.60E-85	11	T333P	missense
T	333	S	2617.797118	0.943287791	1.50E-09	4.41E-09	11	T333S	missense
V	334	A	3689.246866	0.780017374	5.73E-24	2.17E-23	11	V334A	missense
V	334	E	2282.09432	1.023380031	2.39E-60	1.71E-59	11	V334E	missense
V	334	L	242.1973276	0.584857117	2.82E-22	1.02E-21	11	V334L	missense
V	334	M	741.5315957	0.409519844	2.53E-23	9.38E-23	11	V334M	missense
A	335	D	58.84276318	-2.403104244	1.41E-52	9.12E-52	11	A335D	missense
A	335	G	210.5294856	0.927291902	1.07E-28	4.45E-28	11	A335G	missense
A	335	P	32.8636856	-2.921686141	2.88E-55	1.89E-54	11	A335P	missense
A	335	S	413.3653077	0.591226069	9.47E-25	3.72E-24	11	A335S	missense
A	335	T	1162.462913	0.158556321	0.003324077	0.008008004	11	A335T	missense
A	335	V	623.7523793	-0.469633386	1.64E-25	6.47E-25	11	A335V	missense
S	336	A	77.19708463	0.69396729	4.48E-09	1.30E-08	11	S336A	missense
S	336	F	301.0322897	-0.726590643	7.43E-49	4.33E-48	11	S336F	missense
S	336	P	828.0854883	-2.589750197	1.02E-173	1.51E-172	11	S336P	missense
S	336	T	898.3959395	0.461030399	2.01E-33	8.87E-33	11	S336T	missense
S	336	Y	99.59489273	-0.266386309	6.71E-04	0.001660611	11	S336Y	missense
S	337	A	102.8716208	0.599397877	1.07E-13	3.44E-13	11	S337A	missense
S	337	L	382.9169091	-1.872136344	1.68E-38	8.23E-38	11	S337L	missense
S	337	P	624.1307717	-3.184715386	3.81E-68	3.06E-67	11	S337P	missense
S	337	T	1293.708504	0.428729784	6.01E-39	3.01E-38	11	S337T	missense
S	338	A	79.26816719	0.508281741	8.28E-08	2.36E-07	11	S338A	missense
S	338	F	298.7838026	-1.027518621	6.40E-26	2.55E-25	11	S338F	missense
S	338	P	1620.007809	-1.846179355	8.40E-47	4.74E-46	11	S338P	missense
S	338	T	808.6299566	0.281598372	6.18E-13	1.96E-12	11	S338T	missense
S	338	Y	252.5029734	-0.6314989	1.26E-12	3.94E-12	11	S338Y	missense
T	339	R	85.32381583	-3.95775653	3.68E-47	2.10E-46	11	T339R	missense
T	339	I	491.7729118	-2.169256841	4.95E-31	2.10E-30	11	T339I	missense
T	339	K	92.23132836	-2.370605394	1.94E-24	7.49E-24	11	T339K	missense
T	339	P	59.55455769	-4.2458686	7.40E-65	5.60E-64	11	T339P	missense
T	339	S	1586.693603	0.38422987	1.79E-21	6.25E-21	11	T339S	missense
A	340	D	610.0172736	-0.598728035	0.003944633	0.009459979	11	A340D	missense
A	340	G	141.0496481	0.666345455	1.30E-12	4.04E-12	11	A340G	missense
A	340	P	48.82935915	-2.325150465	7.71E-13	2.43E-12	11	A340P	missense
A	340	S	500.2808066	0.60086731	5.70E-51	3.43E-50	11	A340S	missense
A	340	T	575.428926	0.129627748	0.008237335	0.019232545	11	A340T	missense
A	340	V	494.4058414	-0.494776822	2.83E-30	1.18E-29	11	A340V	missense
V	341	A	2356.245742	0.973767797	6.54E-107	7.08E-106	11	V341A	missense
V	341	D	655.1080547	-2.12202575	1.03E-19	3.54E-19	11	V341D	missense
V	341	I	571.447304	0.24441735	9.08E-07	2.53E-06	11	V341I	missense
V	341	L	132.6446158	0.471648649	6.69E-10	1.98E-09	11	V341L	missense
I	342	L	1587.617694	0.706605245	8.26E-52	5.15E-51	11	I342L	missense
I	342	K	783.9364264	0.956205056	6.37E-35	2.91E-34	11	I342K	missense
I	342	M	1324.427907	0.848125774	1.29E-150	1.71E-149	11	I342M	missense
I	342	T	1539.318108	1.098076563	1.55E-110	1.72E-109	11	I342T	missense
I	342	V	2075.089378	0.769664988	4.91E-171	7.04E-170	11	I342V	missense
V	343	A	1824.402694	1.005445662	1.27E-153	1.77E-152	11	V343A	missense
V	343	D	493.1736055	-0.360755593	0.019166575	0.043226743	11	V343D	missense
V	343	G	108.7299595	1.007600919	4.94E-38	2.40E-37	11	V343G	missense
V	343	I	424.0500291	0.309570082	2.95E-11	8.99E-11	11	V343I	missense
V	343	L	47.58172813	0.646523555	1.05E-06	2.89E-06	11	V343L	missense
V	343	F	362.4016072	0.309404401	1.43E-10	4.29E-10	11	V343F	missense
S	344	A	150.6994999	0.861848435	1.84E-16	5.51E-16	12	S344A	missense
S	344	L	294.1555718	-0.178956726	0.006212636	0.013836111	12	S344L	missense
S	344	T	1408.592893	0.765566099	3.45E-34	1.32E-33	12	S344T	missense
A	345	D	325.8086977	1.022801358	1.57E-16	4.72E-16	12	A345D	missense
A	345	G	150.134875	1.301017788	3.46E-42	1.54E-41	12	A345G	missense
A	345	P	77.1025339	0.871229578	1.84E-12	5.03E-12	12	A345P	missense
A	345	S	331.9227514	1.220307819	1.25E-87	9.08E-87	12	A345S	missense
A	345	T	660.7440173	1.066076461	5.10E-30	1.85E-29	12	A345T	missense
R	346	C	388.3680556	-3.291885431	1.80E-77	1.17E-76	12	R346C	missense
R	346	G	10.05830059	-1.939371074	3.24E-12	8.76E-12	12	R346G	missense
R	346	L	132.8324007	-2.565276448	8.22E-62	4.60E-61	12	R346L	missense
R	346	P	50.8056685	-1.886364717	4.65E-31	1.70E-30	12	R346P	missense
R	346	S	170.5327564	-2.781074279	8.69E-122	7.96E-121	12	R346S	missense
M	347	R	134.4026243	1.138876139	1.19E-49	5.69E-49	12	M347R	missense
M	347	I	754.4958125	0.764501396	8.49E-28	3.00E-27	12	M347I	missense
M	347	L	794.8772049	0.793515238	1.36E-46	6.23E-46	12	M347L	missense
M	347	K	886.5920252	1.278591842	1.32E-102	1.05E-101	12	M347K	missense
M	347	T	2103.730812	1.275918221	7.89E-52	4.01E-51	12	M347T	missense
M	347	V	1531.952277	0.980093341	9.35E-67	5.44E-66	12	M347V	missense
A	348	G	134.9567062	0.672914004	9.99E-18	3.09E-17	12	A348G	missense
A	348	P	134.7652752	1.164669882	1.90E-35	7.54E-35	12	A348P	missense
A	348	S	207.7644935	0.837997612	9.17E-38	3.69E-37	12	A348S	missense
A	348	T	622.3171485	0.893660557	3.47E-16	1.03E-15	12	A348T	missense
A	348	V	1141.597805	0.905992976	1.17E-44	5.25E-44	12	A348V	missense
P	349	A	48.63606963	1.269261901	1.54E-18	4.88E-18	12	P349A	missense
P	349	R	57.81350454	0.929348679	1.70E-18	5.36E-18	12	P349R	missense
P	349	H	491.708487	0.950261286	1.58E-39	6.55E-39	12	P349H	missense
P	349	L	963.8343054	0.799958207	2.19E-21	7.13E-21	12	P349L	missense
P	349	S	637.3116032	0.793262104	7.85E-51	3.92E-50	12	P349S	missense
P	349	T	277.1915073	0.712107409	2.91E-12	7.91E-12	12	P349T	missense
E	350	A	84.78017967	0.74359801	1.38E-12	3.80E-12	12	E350A	missense
E	350	D	350.3205108	0.82890332	1.31E-34	5.07E-34	12	E350D	missense
E	350	Q	38.6670007	1.1932029	9.83E-17	2.99E-16	12	E350Q	missense
E	350	G	1000.270388	0.332914839	1.29E-25	4.52E-25	12	E350G	missense
E	350	K	1657.035102	1.49886607	4.56E-129	1.16E-127	12	E350K	missense
E	350	V	923.9580632	0.787940797	3.54E-48	1.66E-47	12	E350V	missense
E	351	A	99.82890239	1.330261129	1.87E-40	7.93E-40	12	E351A	missense
E	351	D	168.4468988	-0.180401303	0.002634428	0.005986364	12	E351D	missense
E	351	Q	14.92950271	0.875696636	4.72E-04	0.001128676	12	E351Q	missense
E	351	G	612.5550789	-0.409250457	2.53E-12	6.90E-12	12	E351G	missense
E	351	K	237.2943685	0.850718314	7.51E-07	1.90E-06	12	E351K	missense
E	351	V	884.7928498	0.961665057	1.22E-40	5.22E-40	12	E351V	missense
I	352	N	215.2960971	-2.12049178	2.53E-136	7.86E-135	12	I352N	missense
I	352	L	78.47824868	1.025849639	2.20E-19	7.01E-19	12	I352L	missense
I	352	M	23.42867685	0.743680955	4.38E-07	1.11E-06	12	I352M	missense
I	352	F	720.2222544	1.122899495	7.87E-160	3.66E-158	12	I352F	missense
I	352	S	26.49806979	-0.494115474	0.001591777	0.00369213	12	I352S	missense
I	352	T	798.2558239	0.347873885	2.76E-10	7.23E-10	12	I352T	missense
I	352	V	909.548561	0.529205085	8.83E-42	3.89E-41	12	I352V	missense
I	353	N	256.8913356	-2.574832953	3.00E-125	4.30E-124	12	I353N	missense
I	353	M	27.95657807	-1.062510221	1.02E-12	2.83E-12	12	I353M	missense
I	353	F	152.598664	-2.278141609	4.41E-52	2.26E-51	12	I353F	missense
I	353	S	26.02610756	-1.589416154	1.82E-22	6.05E-22	12	I353S	missense
I	353	T	597.0737671	-0.79859695	5.64E-13	1.57E-12	12	I353T	missense
I	353	V	1669.459492	1.112138318	1.74E-80	1.18E-79	12	I353V	missense
M	354	R	28.96911766	-2.267602564	5.85E-23	1.97E-22	12	M354R	missense
M	354	I	2841.720207	1.720049768	6.94E-54	3.63E-53	12	M354I	missense
M	354	L	1552.383924	1.31261698	3.18E-71	1.93E-70	12	M354L	missense
M	354	K	212.8951658	-2.631236185	1.02E-73	6.35E-73	12	M354K	missense
M	354	T	441.1081404	-3.28556712	4.35E-208	4.05E-206	12	M354T	missense
M	354	V	1514.87704	1.280489541	2.10E-78	1.39E-77	12	M354V	missense
D	355	A	24.50138514	-2.841028746	2.71E-38	1.11E-37	12	D355A	missense
D	355	N	430.3829457	0.273196671	1.51E-04	3.66E-04	12	D355N	missense
D	355	E	108.7355507	-2.110907684	1.18E-67	6.92E-67	12	D355E	missense
D	355	G	521.0598467	-2.796627217	3.80E-85	2.73E-84	12	D355G	missense
D	355	H	15.86101648	-1.27133612	1.05E-08	2.72E-08	12	D355H	missense
D	355	Y	102.8128967	-2.198826634	9.46E-51	4.68E-50	12	D355Y	missense
D	355	V	238.947618	-3.297017818	6.45E-74	4.05E-73	12	D355V	missense
R	356	G	611.3626983	-1.060402204	1.95E-104	1.58E-103	12	R356G	missense
R	356	I	111.6881305	-1.619538992	4.99E-33	1.86E-32	12	R356I	missense
R	356	K	265.6339635	0.632756385	1.10E-28	3.93E-28	12	R356K	missense
R	356	S	171.6505614	-0.773478742	1.45E-27	5.09E-27	12	R356S	missense
P	357	A	46.08135715	-1.915142113	3.21E-23	1.09E-22	12	P357A	missense
P	357	R	22.35258534	-1.782588032	6.18E-18	1.94E-17	12	P357R	missense
P	357	H	134.6590321	-2.453406111	1.04E-31	3.83E-31	12	P357H	missense
P	357	L	189.4113856	-3.310443985	1.31E-112	1.13E-111	12	P357L	missense
P	357	S	209.4254071	-1.16313251	1.52E-93	1.18E-92	12	P357S	missense
P	357	T	34.57428977	-1.116226708	5.49E-09	1.43E-08	12	P357T	missense
F	358	C	18.01123009	-3.802621671	1.52E-34	5.87E-34	12	F358C	missense
F	358	I	196.4518434	-3.427435786	9.33E-119	8.15E-118	12	F358I	missense
F	358	L	620.5459958	-2.543518092	1.51E-50	7.33E-50	12	F358L	missense
F	358	S	458.0200225	-3.127677347	5.29E-69	3.14E-68	12	F358S	missense
F	358	Y	280.8380752	-1.323372655	5.48E-51	2.76E-50	12	F358Y	missense
F	358	V	27.46044465	-2.803539394	8.83E-39	3.63E-38	12	F358V	missense
L	359	R	16.55233084	-3.709191287	5.82E-33	2.16E-32	12	L359R	missense
L	359	H	265.6925621	-0.596087651	1.17E-11	3.14E-11	12	L359H	missense
L	359	I	282.9185595	0.918126514	3.24E-33	1.22E-32	12	L359I	missense
L	359	P	354.726282	-3.081708737	1.21E-97	9.53E-97	12	L359P	missense
L	359	V	39.54501295	0.622359047	2.39E-05	5.97E-05	12	L359V	missense
F	360	C	36.5227749	-2.002101138	3.26E-40	1.37E-39	12	F360C	missense
F	360	I	773.5984126	-0.426622724	1.61E-14	4.63E-14	12	F360I	missense
F	360	L	997.5496686	-0.989279423	6.58E-134	1.84E-132	12	F360L	missense
F	360	S	348.3299852	-2.722744505	3.02E-127	6.76E-126	12	F360S	missense
F	360	Y	346.2269426	-1.332167871	4.86E-33	1.82E-32	12	F360Y	missense
F	360	V	63.80130235	-0.943271197	2.88E-15	8.34E-15	12	F360V	missense
V	361	A	1150.695177	0.223030989	3.02E-08	7.73E-08	12	V361A	missense
V	361	E	306.0164223	-3.311280474	3.80E-80	2.56E-79	12	V361E	missense
V	361	G	62.90926718	-2.182103595	2.75E-82	1.90E-81	12	V361G	missense
V	361	L	99.10277983	0.454336577	9.25E-05	2.27E-04	12	V361L	missense
V	361	M	417.1630506	0.23824127	2.80E-04	6.71E-04	12	V361M	missense
V	362	A	539.8798756	-1.715541113	8.25E-142	3.07E-140	12	V362A	missense
V	362	D	243.9264351	-3.50094475	1.01E-89	7.74E-89	12	V362D	missense
V	362	G	59.2337313	-1.146753775	5.43E-22	1.80E-21	12	V362G	missense
V	362	I	434.331443	0.632639087	2.05E-24	7.03E-24	12	V362I	missense
V	362	L	24.00466694	-0.948005989	1.43E-08	3.69E-08	12	V362L	missense
V	362	F	62.59552968	-1.456693386	7.58E-22	2.49E-21	12	V362F	missense
R	363	Q	1089.683086	0.515128191	6.16E-16	1.79E-15	12	R363Q	missense
R	363	G	58.18576748	-1.429356597	5.41E-35	2.11E-34	12	R363G	missense
R	363	L	1232.208431	0.872691392	4.20E-56	2.22E-55	12	R363L	missense
R	363	P	45.11877668	-2.065671219	5.53E-45	2.49E-44	12	R363P	missense
H	364	R	468.866022	-2.844549549	0	0	12	H364R	missense
H	364	N	124.8781368	-1.311324523	5.36E-25	1.86E-24	12	H364N	missense
H	364	D	133.9641253	-0.434778386	2.44E-06	6.15E-06	12	H364D	missense
H	364	Q	49.15093018	-0.980030415	2.43E-11	6.49E-11	12	H364Q	missense
H	364	L	295.0900095	-2.487017484	1.17E-107	9.79E-107	12	H364L	missense
H	364	P	24.95105128	-3.019675023	7.24E-40	3.02E-39	12	H364P	missense
H	364	Y	522.124967	-1.185088602	5.13E-138	1.69E-136	12	H364Y	missense
N	365	D	491.3012582	-1.008551905	1.44E-104	1.18E-103	12	N365D	missense
N	365	H	48.60322169	-1.19435416	2.59E-24	8.82E-24	12	N365H	missense
N	365	I	233.6825516	-1.226949224	1.81E-57	9.72E-57	12	N365I	missense
N	365	K	122.6071391	-1.281934619	4.95E-61	2.74E-60	12	N365K	missense
N	365	S	526.9037392	-1.268047112	3.01E-233	4.21E-231	12	N365S	missense
N	365	T	35.58735958	-1.213324417	8.35E-18	2.61E-17	12	N365T	missense
N	365	Y	174.9140392	-2.618972341	7.61E-131	2.02E-129	12	N365Y	missense
P	366	A	157.8975908	0.785171006	3.22E-14	9.10E-14	12	P366A	missense
P	366	R	50.05323358	0.284996904	0.022322798	0.047446555	12	P366R	missense
P	366	L	456.0938563	-0.168559276	0.003488885	0.007811977	12	P366L	missense
P	366	S	563.2219391	0.279097665	7.74E-09	2.01E-08	12	P366S	missense
T	367	A	494.1300401	-2.246230882	0	0	12	T367A	missense
T	367	R	49.89443906	-2.204397402	6.51E-58	3.53E-57	12	T367R	missense
T	367	I	271.0101694	-2.136264825	6.53E-201	5.22E-199	12	T367I	missense
T	367	K	36.37059245	-1.651379919	4.18E-16	1.22E-15	12	T367K	missense
T	367	P	73.51713231	-3.204012347	9.45E-108	8.00E-107	12	T367P	missense
T	367	S	1584.331161	0.784025595	4.11E-47	1.92E-46	12	T367S	missense
G	368	R	219.1441041	-0.633019013	2.18E-17	6.70E-17	12	G368R	missense
G	368	E	347.9904376	0.460984808	9.89E-18	3.07E-17	12	G368E	missense
G	368	V	69.19755331	-1.736336962	5.44E-38	2.21E-37	12	G368V	missense
T	369	A	3166.303996	1.361953824	4.10E-84	2.90E-83	12	T369A	missense
T	369	R	22.97946683	-1.93350254	1.40E-22	4.70E-22	12	T369R	missense
T	369	I	473.4002736	0.436481776	1.55E-24	5.36E-24	12	T369I	missense
T	369	K	25.07579501	-0.593696988	0.001655418	0.00382388	12	T369K	missense
T	369	P	26.99971753	-3.294925502	1.66E-49	7.86E-49	12	T369P	missense
T	369	S	526.9746201	0.318660969	1.94E-07	4.94E-07	12	T369S	missense
V	370	A	611.3204179	-0.710159258	1.17E-82	8.16E-82	12	V370A	missense
V	370	D	259.9305199	-1.467566745	5.10E-41	2.19E-40	12	V370D	missense
V	370	G	21.26904403	-2.801731888	2.58E-33	9.82E-33	12	V370G	missense
V	370	I	775.818474	1.655200452	1.07E-175	5.97E-174	12	V370I	missense
V	370	L	84.52192946	1.30917128	2.26E-35	8.88E-35	12	V370L	missense
L	371	R	32.06637527	-3.295479459	3.85E-53	1.99E-52	12	L371R	missense
L	371	H	171.2970504	-2.307119192	2.18E-160	1.11E-158	12	L371H	missense
L	371	F	253.5647884	-0.699135994	3.41E-15	9.84E-15	12	L371F	missense
L	371	P	434.661186	-1.947188728	7.33E-46	3.33E-45	12	L371P	missense
L	371	V	39.63089219	0.718304345	0.002560587	0.005842319	12	L371V	missense
F	372	C	218.5207449	1.032859848	4.86E-11	1.29E-10	12	F372C	missense
F	372	I	3074.367583	1.887046151	3.55E-121	3.15E-120	12	F372I	missense
F	372	L	6348.784904	2.02053545	3.58E-192	2.50E-190	12	F372L	missense
F	372	S	1275.046976	-0.799525645	9.23E-17	2.82E-16	12	F372S	missense
F	372	Y	330.4699229	-1.700475914	1.59E-143	6.35E-142	12	F372Y	missense
F	372	V	533.2047973	1.962695793	4.70E-70	2.83E-69	12	F372V	missense
M	373	R	28.13147725	-4.146142776	1.27E-50	6.24E-50	12	M373R	missense
M	373	I	1249.139809	1.511585383	3.44E-146	1.48E-144	12	M373I	missense
M	373	L	751.26586	1.239906021	2.53E-134	7.45E-133	12	M373L	missense
M	373	K	220.4823465	-3.635881073	4.15E-77	2.64E-76	12	M373K	missense
M	373	T	1285.416575	0.86257089	3.87E-50	1.86E-49	12	M373T	missense
M	373	V	2138.658017	1.673920513	6.43E-214	7.19E-212	12	M373V	missense
G	374	A	32.92945094	-0.546485661	1.31E-04	3.20E-04	12	G374A	missense
G	374	R	23.72556955	-1.801890081	4.07E-16	1.20E-15	12	G374R	missense
G	374	D	448.0596244	-1.013838458	5.34E-78	3.51E-77	12	G374D	missense
G	374	C	204.2613604	-2.148571132	7.66E-28	2.73E-27	12	G374C	missense
G	374	S	256.3623616	-2.149148912	6.56E-88	4.89E-87	12	G374S	missense
G	374	V	87.94764544	-1.700960724	3.72E-20	1.19E-19	12	G374V	missense
Q	375	R	661.5779059	-0.434311907	2.61E-13	7.32E-13	12	Q375R	missense
Q	375	E	17.52140305	-0.550483992	0.002138742	0.004919986	12	Q375E	missense
Q	375	H	1486.746035	0.858353702	1.97E-41	8.62E-41	12	Q375H	missense
Q	375	L	698.9194804	0.266013215	1.36E-10	3.58E-10	12	Q375L	missense
Q	375	P	44.14087053	-3.773379983	1.11E-62	6.27E-62	12	Q375P	missense
V	376	A	411.1733723	-2.050025647	5.96E-89	4.50E-88	12	V376A	missense
V	376	E	231.4982674	-2.818178152	3.69E-59	2.02E-58	12	V376E	missense
V	376	G	40.60016894	-3.697797058	4.31E-73	2.65E-72	12	V376G	missense
V	376	L	191.3304928	0.550372546	3.20E-16	9.51E-16	12	V376L	missense
V	376	M	272.43278	0.411558459	3.25E-13	9.08E-13	12	V376M	missense
M	377	R	20.42284304	-2.388106545	2.90E-29	1.04E-28	12	M377R	missense
M	377	I	328.0341278	-0.702398506	1.77E-14	5.06E-14	12	M377I	missense
M	377	K	156.6202095	-1.466849887	2.09E-77	1.34E-76	12	M377K	missense
M	377	V	712.5843367	-0.330729807	1.38E-04	3.36E-04	12	M377V	missense
E	378	A	30.48744246	-1.031791902	2.84E-11	7.56E-11	12	E378A	missense
E	378	D	1622.089541	1.781569753	1.74E-63	9.90E-63	12	E378D	missense
E	378	G	529.2604318	-2.654217213	9.30E-47	4.30E-46	12	E378G	missense
E	378	K	175.9682775	-2.090603282	8.14E-88	5.99E-87	12	E378K	missense
E	378	V	313.8084114	-0.736287748	5.75E-05	1.42E-04	12	E378V	missense
P	379	A	46.10954076	-2.387840796	3.56E-56	1.90E-55	12	P379A	missense
P	379	R	23.967128	-2.500981003	1.87E-35	7.46E-35	12	P379R	missense
P	379	H	193.2257996	-3.041757311	2.42E-64	1.39E-63	12	P379H	missense
P	379	L	222.5230669	-0.767031205	2.49E-14	7.07E-14	12	P379L	missense
P	379	S	186.7269685	-3.207170082	4.89E-188	3.04E-186	12	P379S	missense
P	379	T	35.88520358	-1.700745476	1.13E-21	3.71E-21	12	P379T	missense