<1. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28296716 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - North WD AU - Kubajak CS AU - St Martin B AU - Rinker B FA - North, William Darden FA - Kubajak, Christopher S FA - St Martin, Brad FA - Rinker, Brian IN - North, William Darden. From the *University of Kentucky Department of Surgery, Division of Plastic and Reconstructive Surgery; and +University of Kentucky College of Medicine, Lexington, KY. TI - Dermal Autograft Using Donor Breast as Alternative to Acellular Dermal Matrices in Tissue Expander Breast Reconstruction: A Comparative Review. SO - Annals of Plastic Surgery. 78(6S Suppl 5):S282-S285, 2017 Jun AS - Ann Plast Surg. 78(6S Suppl 5):S282-S285, 2017 Jun NJ - Annals of plastic surgery VO - 78 IP - 6S Suppl 5 PG - S282-S285 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Analysis of Variance MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Female MH - Graft Rejection MH - Graft Survival MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Prognosis MH - Retrospective Studies MH - Risk Assessment MH - *Skin Transplantation/mt [Methods] MH - Statistics, Nonparametric MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - *Transplant Donor Site/ph [Physiology] MH - Transplantation, Autologous MH - Treatment Outcome AB - BACKGROUND: Shifting preference for implant-based breast reconstruction has resulted in an increased use of acellular dermal matrix (ADM) in tissue-expander breast reconstruction. The benefits afforded by ADM must be weighed against a potential increased risk for postoperative complications. Dermal autograft-assisted breast reconstruction using autograft harvest from the lower abdomen has been shown to result in equivalent aesthetics and patient satisfaction compared with ADM at a lower cost, with fewer complications. The purpose of this study was to review a series of patients who underwent bilateral mastectomy and immediate dermal autograft-assisted tissue expander (TE) breast reconstruction using the non-cancerous breast as a donor site, comparing the outcomes with a concurrent cohort of patients undergoing ADM-assisted reconstruction to determine the relative safety, cost, and effectiveness of the 2 procedures. AB - METHODS: The study population included all patients who underwent dermal autograft-assisted TE breast reconstruction, using the contralateral cancer-free breast as the source of dermal autograft, between 2010 and 2015. The ADM cohort consisted of patients who underwent bilateral mastectomy and immediate ADM-assisted TE breast reconstruction during the same period. Univariate analysis was performed for demographic data, complications, operative cost, and operative time. Data were compared using the Wilcoxon rank sum test for nonparametric data and chi analyses for continuous and categorical variables. Significance was defined as P value less than 0.05. AB - RESULTS: Seventeen patients received dermal autograft using the non-cancerous breast donor site. Twenty-seven patients who underwent ADM-assisted reconstruction during the same period were identified. Significantly higher cost was demonstrated between groups (ADM, US $9999.87; autograft, US $3924.19; P < 0.0001). No significance difference existed operative time (autograft, 97 min; ADM, 120 min). No difference was found in wound healing complications (ADM, 14.8%; autograft, 23.53%; P = 0.47). No significant difference was found in major complications (ADM, 26%; autograft, 17.65%; P = 0.52) or infectious complications (ADM, 26%; autograft, 17.65%; P = 0.52). AB - CONCLUSIONS: Dermal autograft-assisted breast reconstruction using the contralateral non-cancerous breast as the source of dermal autograft harvest represents a lower cost alternative to ADM without increased risk of postoperative complications. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001041 PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0000000000001041 [doi] PP - ppublish LG - English DP - 2017 Jun EZ - 2017/03/16 06:00 DA - 2018/04/05 06:00 DT - 2017/03/16 06:00 YR - 2017 ED - 20180404 RD - 20180404 UP - 20180405 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28296716 <2. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25266930 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Berna G AU - Cawthorn SJ AU - Papaccio G AU - Balestrieri N FA - Berna, Giorgio FA - Cawthorn, Simon J FA - Papaccio, Guido FA - Balestrieri, Nicola IN - Berna, Giorgio. Department of Plastic and Reconstructive Surgery, Ulss 9 General Hospital, Treviso, Italy. IN - Cawthorn, Simon J. Breast Care Center, North Bristol NHS Trust, Bristol, UK. IN - Papaccio, Guido. Breast Care Center, Ulss 12 General Hospital, Mestre, Italy. IN - Balestrieri, Nicola. Breast Care Center, Ulss 9 General Hospital, Treviso, Italy. TI - Evaluation of a novel breast reconstruction technique using the Braxon acellular dermal matrix: a new muscle-sparing breast reconstruction. SO - ANZ Journal of Surgery. 87(6):493-498, 2017 Jun AS - ANZ J Surg. 87(6):493-498, 2017 Jun NJ - ANZ journal of surgery VO - 87 IP - 6 PG - 493-498 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dze, 101086634 IO - ANZ J Surg SB - Index Medicus CP - Australia MH - *Acellular Dermis/st [Standards] MH - Animals MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Breast Implantation/sn [Statistics & Numerical Data] MH - *Breast Implants/ut [Utilization] MH - Breast Implants/ve [Veterinary] MH - Cosmetic Techniques/st [Standards] MH - Esthetics/px [Psychology] MH - Female MH - Humans MH - Implant Capsular Contracture/co [Complications] MH - Incidence MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Outcome Assessment (Health Care) MH - *Pectoralis Muscles/su [Surgery] MH - Retrospective Studies MH - Seroma/co [Complications] MH - Swine KW - ADM; Braxon; breast reconstruction; muscle-sparing; pectoralis major AB - BACKGROUND: Implant-based breast reconstruction is becoming increasingly popular because of the widespread adoption of acellular dermal matrix (ADM), which allows surgeons to obtain good aesthetic results with fewer operations. To develop more conservative surgical techniques, a retrospective, three-centre, proof-of-concept study was performed to study the effectiveness of a new, immediate, muscle-sparing breast reconstruction technique using the patented Braxon ADM, which enables subcutaneous positioning of the breast implant without detaching the pectoralis major. AB - METHODS: Ethics committee of the study coordinating centre approved medical record review on 19 women who underwent muscle-sparing breast reconstruction between November 2012 and January 2014. The first 10 implants were performed using 0.9-mm-thick porcine ADM, with preservatives. In the subsequent 15 implants, the product was changed to 0.6-mm-thick porcine dry ADM, without preservatives. AB - RESULTS: Nineteen patients (25 implants) received six bilateral and 13 unilateral muscle-sparing breast reconstructions. For the first type of ADM used (0.9-mm-thick with preservatives), the rate of implant loss was 12% (n=3) because of seroma (8%, n=2) and infection (4%, n=1). Minor complications, such as seroma (8%, n=2), occurred when using the 0.6-mm-thick Braxon ADM and were treated by aspiration. Symmetrical and natural breasts with good shape, ptosis and softness to the touch were obtained. None of the patients reported experiencing pain. AB - CONCLUSIONS: The preliminary results are encouraging from aesthetic and clinical viewpoints. Further studies are planned to evaluate long-term results. Copyright © 2014 Royal Australasian College of Surgeons. ES - 1445-2197 IL - 1445-1433 DO - https://dx.doi.org/10.1111/ans.12849 PT - Journal Article ID - 10.1111/ans.12849 [doi] PP - ppublish PH - 2014/08/13 [accepted] LG - English EP - 20140929 DP - 2017 Jun EZ - 2014/10/01 06:00 DA - 2018/03/27 06:00 DT - 2014/10/01 06:00 YR - 2017 ED - 20180326 RD - 20180326 UP - 20180327 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=25266930 <3. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28652438 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Eichler C AU - Efremova J AU - Brunnert K AU - Kurbacher CM AU - Gluz O AU - Puppe J AU - Warm M FA - Eichler, Christian FA - Efremova, Jeria FA - Brunnert, Klaus FA - Kurbacher, Christian M FA - Gluz, Oleg FA - Puppe, Julian FA - Warm, Mathias IN - Eichler, Christian. Breast Center, Municipal Hospital Holweide, Cologne, Germany ceichler@gmail.com eichlerc@kliniken-koeln.de. IN - Eichler, Christian. Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany. IN - Efremova, Jeria. Breast Center, Municipal Hospital Holweide, Cologne, Germany. IN - Brunnert, Klaus. Department of Senology, Clinic for Senology, Osnabrueck, Germany. IN - Kurbacher, Christian M. Clinic Center Bonn-Friedensplatz, Bonn, Germany. IN - Kurbacher, Christian M. Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Gluz, Oleg. West German Study Group (WSG), Moenchengladbach, Germany. IN - Gluz, Oleg. Breast Center Niederrhein Moenchengladbach, Moenchengladbach, Germany. IN - Puppe, Julian. Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Warm, Mathias. Breast Center, Municipal Hospital Holweide, Cologne, Germany. IN - Warm, Mathias. Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. TI - A Head to Head Comparison Between SurgiMend - Fetal Bovine Acellular Dermal Matrix and Tutomesh - A Bovine Pericardium Collagen Membrane in Breast Reconstruction in 45 Cases. SO - In Vivo. 31(4):677-682, 2017 Jul-Aug AS - In Vivo. 31(4):677-682, 2017 Jul-Aug NJ - In vivo (Athens, Greece) VO - 31 IP - 4 PG - 677-682 PI - Journal available in: Print PI - Citation processed from: Internet JC - a6f, 8806809 IO - In Vivo SB - Index Medicus CP - Greece MH - Adult MH - Aged MH - Animals MH - Breast Implantation/mt [Methods] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cattle MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Polytetrafluoroethylene/tu [Therapeutic Use] MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pa [Pathology] KW - *ADM; *Breast cancer; *SurgiMend; *Tutomesh; *acellular dermal matrix; *reconstruction AB - BACKGROUND/AIM: The use of acellular dermal matrices (ADM) has become a widely used option in breast reconstruction. A great deal of literature is available, totaling over 3,200 ADM reconstructions. Head-to-head comparisons between SurgiMend and Tutomesh are not yet reported. These are the first comparative clinical data reported on the use of Tutomesh in breast reconstruction. Postoperative complication rates and costs for these devices were evaluated. AB - PATIENTS AND METHODS: This is a retrospective analysis of a 2-year experience with both SurgiMend - fetal bovine acellular dermal matrix and Tutomesh - a bovine pericardium collagen membrane in breast reconstruction in 45 cases from 2014-2015. AB - RESULTS: Forty-five patients received a total of 45 implant-based reconstructions using SurgiMend (18 cases; 40%) or Tutomesh (27 cases; 60%). Gross complication rates were 27.8% for SurgiMend and 37.0% for Tutomesh including hematoma, postoperative skin irritation, infection, red breast syndrome and revision surgery. The most common complication was postoperative red breast syndrome. Severe complications requiring revision surgery did not differ significantly in patients treated with SurgiMend (0 cases, 0%) compared to Tutomesh (1 case, 3.7%). AB - CONCLUSION: This retrospective analysis shows similar overall clinical complication rates for Tutomesh and SurgiMend. Severe complication rates are comparable to those reported in literature for both products. Although the retrospective nature of this work limits its clinical impact, it is possible to opt for the cheaper alternative (Tutomesh). Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. RN - 0 (Surgimend) RN - 0 (Tutoplast) RN - 9002-84-0 (Polytetrafluoroethylene) RN - 9007-34-5 (Collagen) ES - 1791-7549 IL - 0258-851X PT - Journal Article ID - 31/4/677 [pii] ID - PMC5566921 [pmc] ID - 10.21873/invivo.11112 [doi] PP - ppublish PH - 2017/04/18 [received] PH - 2017/05/07 [revised] PH - 2017/05/08 [accepted] LG - English DP - 2017 Jul-Aug EZ - 2017/06/28 06:00 DA - 2018/03/22 06:00 DT - 2017/06/28 06:00 YR - 2017 ED - 20180321 RD - 20180321 UP - 20180322 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28652438 <4. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28106627 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Seth AK AU - Hirsch EM AU - Kim JYS AU - Fine NA FA - Seth, Akhil K FA - Hirsch, Elliot M FA - Kim, John Y S FA - Fine, Neil A IN - Seth, Akhil K. From the *Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA; and +Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL. TI - Outcomes After Elevation of Serratus Anterior Fascia During Prosthetic Breast Reconstruction. SO - Annals of Plastic Surgery. 78(6):641-645, 2017 Jun AS - Ann Plast Surg. 78(6):641-645, 2017 Jun NJ - Annals of plastic surgery VO - 78 IP - 6 PG - 641-645 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis MH - *Breast Implants MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - *Fascia MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Retrospective Studies MH - Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Achieving optimal inferolateral coverage is critical to successful prosthetic breast reconstruction. Serratus anterior fascia (SF) elevation, a promising alternative to muscle flaps and acellular dermis (ADM), has not been rigorously studied. This study evaluates complication rates after mastectomy and immediate tissue expander (TE) coverage using SF, relative to other existing methods of reconstruction. AB - METHODS: Retrospective review of consecutive patients undergoing mastectomy with immediate TE reconstruction over 10 years at 1 institution was performed. Patients with serratus muscle (SM) or SF elevation were analyzed. ADM reconstructions were used for comparative analysis only. Relevant demographic and clinical data were recorded. Complications were categorized by type and end outcome, including nonoperative (no further surgery), operative (surgery except explantation), and explantation. AB - RESULTS: The SM and SF elevation was performed in 375 (487 breasts) and 177 (255 breasts) patients, respectively. Mean follow-up was 43.8 months. The SM and SF patients were demographically similar, but SF had higher intraoperative fill volumes (P < 0.0001) and required fewer postoperative expansions (P < 0.0001). There were no differences in complications between SM and SF patients. Regression analysis, adjusted for several variables, revealed that SF was not an independent risk factor for complications. The ADM- and SF-assisted reconstruction also showed no differences in outcomes. AB - CONCLUSIONS: Our review demonstrates that SF elevation is a safe, feasible alternative for achieving inferolateral coverage during prosthetic breast reconstruction. Furthermore, this technique allows for greater fill volumes and less expansions than SM. As a readily available alternative to muscle flaps and ADM, SF elevation should be considered integral to any prosthetic breast reconstruction algorithm. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000967 PT - Journal Article ID - 10.1097/SAP.0000000000000967 [doi] PP - ppublish LG - English DP - 2017 Jun EZ - 2017/01/21 06:00 DA - 2018/01/30 06:00 DT - 2017/01/21 06:00 YR - 2017 ED - 20180129 RD - 20180129 UP - 20180131 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28106627 <5. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27471076 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Iqbal FM AU - Bhatnagar A AU - Vidya R FA - Iqbal, Fahad M FA - Bhatnagar, Anjali FA - Vidya, Raghavan IN - Iqbal, Fahad M. Keele University, Stoke-on-Trent, UK. IN - Bhatnagar, Anjali. Department of Pathology, New Cross Hospital, Wolverhampton, UK. IN - Vidya, Raghavan. Breast Unit, New Cross Hospital, Wolverhampton, UK. Electronic address: raghavan.vidya@nhs.net. TI - Host Integration of an Acellular Dermal Matrix: Braxon Mesh in Breast Reconstruction. SO - Clinical Breast Cancer. 16(6):e209-e211, 2016 12 AS - Clin Breast Cancer. 16(6):e209-e211, 2016 12 NJ - Clinical breast cancer VO - 16 IP - 6 PG - e209-e211 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100898731 IO - Clin. Breast Cancer SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/is [Instrumentation] KW - *Breast; *Implant reconstruction; *Integration; *Mesh; *Prepectoral ES - 1938-0666 IL - 1526-8209 DI - S1526-8209(16)30164-1 DO - https://dx.doi.org/10.1016/j.clbc.2016.06.009 PT - Case Reports PT - Letter ID - S1526-8209(16)30164-1 [pii] ID - 10.1016/j.clbc.2016.06.009 [doi] PP - ppublish PH - 2016/05/02 [received] PH - 2016/06/08 [revised] PH - 2016/06/17 [accepted] LG - English EP - 20160627 DP - 2016 12 EZ - 2016/07/30 06:00 DA - 2018/01/18 06:00 DT - 2016/07/30 06:00 YR - 2016 ED - 20180117 RD - 20180117 UP - 20180118 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=27471076 <6. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29280856 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Scheflan M AU - Grinberg-Rashi H AU - Hod K FA - Scheflan, Michael FA - Grinberg-Rashi, Helena FA - Hod, Keren IN - Scheflan, Michael. Tel Aviv, Israel From private practice; MedTech Industries; and the Research Division, Epidemiological Service, Assuta Medical Center. TI - Bovine Acellular Dermal Matrix in Immediate Breast Reconstruction: A Retrospective, Observational Study with SurgiMend. SO - Plastic & Reconstructive Surgery. 141(1):1e-10e, 2018 01 AS - Plast Reconstr Surg. 141(1):1e-10e, 2018 01 NJ - Plastic and reconstructive surgery VO - 141 IP - 1 PG - 1e-10e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Animals MH - Cattle MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - Logistic Models MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - Retrospective Studies MH - Risk Factors MH - Young Adult AB - BACKGROUND: Acellular dermal matrices can be combined with implant-based breast reconstruction to help optimize outcomes. SurgiMend PRS is a fetal bovine dermis-derived acellular dermal matrix composed of type I collagen and approximately 30 percent type III collagen, sharing many of the properties of human cadaveric acellular dermal matrix. AB - METHODS: This was a retrospective, single-center analysis of 111 adult patients (147 breasts) undergoing one-stage (83.7 percent) or two-stage (16.3 percent) immediate breast reconstruction after mastectomy. The aims were to characterize the safety profile of SurgiMend and investigate associations between risk factors and complications. AB - RESULTS: The mean age of the patients was 47.9 years and the mean body mass index was 24.7 kg/m. After a median follow-up of 24.3 months, the overall rates of minor and major complications were 25.2 percent (n = 37 of 147) and 12.9 percent (n = 19 of 147), respectively. The most common major complications were seroma [n = 12 (8.2 percent)] and necrosis [n = 9 (6.1 percent)]. All occurred within 3 months after surgery. The rate of capsular contracture was 2.7 percent (n = 4). A total of 2.7 percent of implanted breasts (n = 4) required explantation. In a univariate analysis, smokers had a greater risk of major complications (p = 0.013), and postoperative radiation therapy and obesity were associated with an increased risk of capsular contracture (p = 0.006) and explantation (p = 0.006), respectively. In a multivariate analysis, several factors were associated with complications or explantation, including obesity (p < 0.05), preoperative chemotherapy (p < 0.001), and mastectomy weight (p < 0.05). These associations align with other studies of implant-based reconstruction and do not appear to be specific to this acellular dermal matrix. AB - CONCLUSION: The results are consistent with previous analyses of SurgiMend, and support its value in implant-based breast reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 0 (Surgimend) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003982 PT - Journal Article PT - Observational Study ID - 10.1097/PRS.0000000000003982 [doi] ID - 00006534-201801000-00004 [pii] PP - ppublish LG - English DP - 2018 01 EZ - 2017/12/28 06:00 DA - 2018/01/13 06:00 DT - 2017/12/28 06:00 YR - 2018 ED - 20180112 RD - 20180112 UP - 20180115 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29280856 <7. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28204936 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kim SY AU - Bang SI FA - Kim, So Young FA - Bang, Sa Ik IN - Kim, So Young. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong 81, Gangnam-gu, Seoul, 06351, South Korea. IN - Bang, Sa Ik. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong 81, Gangnam-gu, Seoul, 06351, South Korea. si55.bang@samsung.com. TI - Impact of Acellular Dermal Matrix (ADM) Use Under Mastectomy Flap Necrosis on Perioperative Outcomes of Prosthetic Breast Reconstruction. CM - Comment in: Aesthetic Plast Surg. 2017 Apr;41(2):282-283; PMID: 28233127 SO - Aesthetic Plastic Surgery. 41(2):275-281, 2017 Apr AS - Aesthetic Plast Surg. 41(2):275-281, 2017 Apr NJ - Aesthetic plastic surgery VO - 41 IP - 2 PG - 275-281 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - Adult MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - Device Removal MH - Female MH - Humans MH - *Mastectomy/ae [Adverse Effects] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Necrosis/et [Etiology] MH - Necrosis/su [Surgery] MH - Prosthesis-Related Infections/et [Etiology] MH - Prosthesis-Related Infections/th [Therapy] MH - Retrospective Studies MH - Seroma/et [Etiology] MH - Seroma/th [Therapy] MH - Surgical Flaps/bs [Blood Supply] MH - *Surgical Flaps/pa [Pathology] MH - *Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion Devices/ae [Adverse Effects] MH - Treatment Outcome KW - Acellular derma matrix; Mastectomy flap necrosis; Prosthetic breast reconstruction AB - BACKGROUND: There is conflicting data on the potential necrotic complications of acellular dermal matrix (ADM) use in breast reconstruction, and most studies focus on mastectomy flap necrosis as an outcome measure associated with ADM use. The aim of this study was to examine cases with necrotic complications with and without the use of ADM and to investigate whether ADM affected perioperative outcomes in cases with necrotic complications. AB - METHODS: Patients who experienced mastectomy flap necrosis following mastectomy with tissue expander placement between January 2009 and March 2015 were retrospectively reviewed. The primary outcome was explantation of the expander, and other associated outcomes such as seroma or infection were also recorded. AB - RESULTS: A total of 57 breasts with mastectomy flap necrosis were identified: 32 of which were in the non-ADM group and 25 in the ADM group. The rate of explantation was 28% (7/25) in the ADM group versus 6.3% (2/32) in the non-ADM group, which was significantly different (P = 0.034). The ADM group had a significantly higher rate of "major" infection requiring surgical debridement than the non-ADM group (P = 0.016). Multivariate analysis showed that the use of ADM was trending toward an increasing expander rate with borderline significance (P = 0.05). AB - CONCLUSION: This study demonstrated that ADM use under mastectomy flap necrosis was a potential risk for explantation of the expander and major infection. Surgeons should be cautious with the use of ADM with devascularized mastectomy skin flaps prone to necrosis. AB - LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0794-2 PT - Journal Article ID - 10.1007/s00266-017-0794-2 [doi] ID - 10.1007/s00266-017-0794-2 [pii] PP - ppublish PH - 2016/11/14 [received] PH - 2017/01/11 [accepted] LG - English EP - 20170215 DP - 2017 Apr EZ - 2017/02/17 06:00 DA - 2018/01/13 06:00 DT - 2017/02/17 06:00 YR - 2017 ED - 20180112 RD - 20180112 UP - 20180115 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28204936 <8. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28032163 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Imahiyerobo TA Jr AU - Small KH AU - Sackeyfio R AU - Hoffman H AU - Talmor M AI - Talmor, Mia; ORCID: http://orcid.org/0000-0002-4837-6520 FA - Imahiyerobo, Thomas A Jr FA - Small, Kevin H FA - Sackeyfio, Robyn FA - Hoffman, Hannah FA - Talmor, Mia IN - Imahiyerobo, Thomas A Jr. Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Columbia University Medical Center, New York, NY, USA. IN - Small, Kevin H. Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, 425 East 61st Street, 10th Floor, New York, NY, 10065, USA. IN - Sackeyfio, Robyn. Private Plastic Surgery Practice, Grand Rapids, MI, USA. IN - Hoffman, Hannah. Hofstra North Shore Long Island Jewish School of Medicine, Long Island, NY, USA. IN - Talmor, Mia. Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, 425 East 61st Street, 10th Floor, New York, NY, 10065, USA. MiaTMD@aol.com. TI - Transition from Round to Shaped Implants in Immediate Breast Reconstruction: Our Preferred Approach and Clinical Outcomes. SO - Aesthetic Plastic Surgery. 41(2):284-292, 2017 Apr AS - Aesthetic Plast Surg. 41(2):284-292, 2017 Apr NJ - Aesthetic plastic surgery VO - 41 IP - 2 PG - 284-292 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - *Breast Implants MH - Female MH - Humans MH - Mastectomy, Subcutaneous MH - Middle Aged MH - *Prosthesis Design MH - Retrospective Studies MH - Time Factors MH - Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] KW - Breast reconstruction; Nipple-sparing mastectomy; Round implants; Shaped implants AB - BACKGROUND: Smooth, round, silicone implants predominate device-based breast reconstruction in the USA; despite their prevalence, complications can include bottoming out, superior contour deformity, rippling, and/or lateral malposition. This complication profile increases the need for revision surgery and subsequent patient dissatisfaction. With the resurgence of shaped, textured, silicone implants in the USA, we report the senior author's success with these devices and outline a strategy to optimize outcomes in breast reconstruction surgery. AB - METHODS: A retrospective chart review was conducted on a prospectively collected IRB-approved database of nipple-sparing mastectomies (NSMs) with immediate breast reconstruction with smooth, round, silicone implants (Group A) in 2011 in comparison to textured, shaped, silicone implants (Group B) in 2012. Changes in operative technique were highlighted and extrapolated. Outcomes were reviewed. AB - RESULTS: In Group A, 128 NSMs were performed in 76 patients. In Group B, 109 NSMs were performed in 59 patients. Thirteen percent of patients in Group A had direct to implant reconstruction as compared with 21% in Group B. Patients with textured, shaped implants were more likely to have acellular dermal matrix (61 vs 34%, p < 0.0001) than those with smooth, round implants. Patients who had smooth, round implants were more likely to have postoperative nipple malposition (18 vs 0%, p < 0.0001,) and rippling (29 vs 0%, p < 0.0001.) Patients with textured, shaped implants had fewer operative revision reconstructions as compared with those with smooth, round implants (36.71 vs 12.8%, p < 0.0001) Based on these results, our technique has evolved and has eight key technical modifications. AB - CONCLUSION: With a few adaptations in surgical technique, the transition to textured, shaped, silicone devices for breast reconstruction can be seamless with superior breast contour and reduced complications/revision rates. AB - LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-016-0738-2 PT - Journal Article ID - 10.1007/s00266-016-0738-2 [doi] ID - 10.1007/s00266-016-0738-2 [pii] PP - ppublish PH - 2016/07/13 [received] PH - 2016/11/09 [accepted] LG - English EP - 20161228 DP - 2017 Apr EZ - 2016/12/30 06:00 DA - 2018/01/13 06:00 DT - 2016/12/30 06:00 YR - 2017 ED - 20180112 RD - 20180112 UP - 20180115 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28032163 <9. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28301366 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sue GR AU - Long C AU - Lee GK FA - Sue, Gloria R FA - Long, Chao FA - Lee, Gordon K IN - Sue, Gloria R. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA. TI - Management of Mastectomy Skin Necrosis in Implant Based Breast Reconstruction. SO - Annals of Plastic Surgery. 78(5 Suppl 4):S208-S211, 2017 May AS - Ann Plast Surg. 78(5 Suppl 4):S208-S211, 2017 May NJ - Annals of plastic surgery VO - 78 IP - 5 Suppl 4 PG - S208-S211 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - Aged, 80 and over MH - *Breast Implants MH - Demography MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Necrosis MH - *Postoperative Complications/pa [Pathology] MH - *Postoperative Complications/th [Therapy] MH - Retrospective Studies MH - Risk Factors MH - *Skin/pa [Pathology] MH - Surgical Flaps AB - BACKGROUND: Mastectomy skin necrosis is a significant problem after breast reconstruction. This complication may lead to poor wound healing and need for implant removal, which may delay subsequent oncologic treatment. We sought to characterize factors associated with mastectomy skin necrosis and propose a management algorithm. AB - METHODS: A retrospective review was performed on consecutive patients undergoing implant-based breast reconstruction by the senior author from 2006 through 2015. Patient-level factors including age, race, body mass index, history of hypertension, history of diabetes, history of smoking, and history of radiation were collected. Surgical factors including type of mastectomy, location of implant placement, and immediate versus delayed reconstruction were collected. The incidence and treatment of mastectomy skin necrosis were analyzed. AB - RESULTS: A total of 293 patients underwent either unilateral or bilateral implant-based breast reconstructions after mastectomy with a total of 471 reconstructed breasts. Mastectomy skin necrosis was observed in 8.1% of reconstructed breasts. Skin necrosis was not associated with age, hypertension, diabetes, prior radiation, or type of mastectomy. The incidence of skin necrosis was higher among smokers (17.9% vs 5.0%, P < 0.001), among patients with higher body mass index (11.4% vs 6.1%, P = 0.05), patients who underwent immediate reconstruction compared to delayed (9.6% vs 0%, P = 0.004), placement of expander under acellular dermal matrix compared with submuscular placement (12.0% vs 5.2%, P = 0.02), and use of higher initial expander fill volume compared with lower fill volume (11.4% vs 5.4%, P = 0.02).The median necrosis size was 8 cm. The median time to treatment was 15 days postoperatively. In 55% of patients minor necrosis was treated with clinic debridement, whereas 43% had larger areas of necrosis requiring operative debridement. The median size treated with clinic debridement was 5.5 cm, compared to 15 cm for operative debridement. All necrosis was treated in a timely fashion and did not delay adjuvant therapy. AB - CONCLUSIONS: Mastectomy skin necrosis occurred in 8.1% of breasts after implant-based reconstruction. Necrosis less than 10 cm can be treated successfully with local debridement in the clinic setting. Timely and appropriate treatment of skin necrosis with debridement and primary closure expedites wound healing and facilitates tissue expander breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001045 PT - Journal Article ID - 10.1097/SAP.0000000000001045 [doi] PP - ppublish LG - English DP - 2017 May EZ - 2017/03/17 06:00 DA - 2018/01/09 06:00 DT - 2017/03/17 06:00 YR - 2017 ED - 20180108 RD - 20180108 UP - 20180109 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28301366 <10. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27540822 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Guclu Karadag T AU - Aral AM AU - Tuncer S AU - Sencan A AU - Elmas C FA - Guclu Karadag, Tuba FA - Aral, Ali Mubin FA - Tuncer, Serhan FA - Sencan, Ayse FA - Elmas, Cigdem IN - Guclu Karadag, Tuba. a Department of Plastic Surgery , Yildirim Beyazit University, Yenimahalle Research and Training Hospital , Ankara , Turkiye. IN - Aral, Ali Mubin. a Department of Plastic Surgery , Yildirim Beyazit University, Yenimahalle Research and Training Hospital , Ankara , Turkiye. IN - Tuncer, Serhan. b Faculty of Medicine, Department of Plastic and Reconstructive Surgery , Gazi University , Ankara , Turkiye. IN - Sencan, Ayse. c Bagcilar Research and Training Hospital , Istanbul , Turkiye. IN - Elmas, Cigdem. d Faculty of Medicine, Department of Histology , Gazi University , Ankara , Turkiye. TI - The effect of skin expansion on acellular dermis in an experimental model. SO - Journal of Plastic Surgery and Hand Surgery. 51(3):187-192, 2017 Jun AS - J Plast Surg Hand Surg. 51(3):187-192, 2017 Jun NJ - Journal of plastic surgery and hand surgery VO - 51 IP - 3 PG - 187-192 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg SB - Index Medicus CP - Sweden MH - *Acellular Dermis MH - Animals MH - Rats, Wistar MH - *Skin/ah [Anatomy & Histology] MH - *Skin Transplantation MH - *Tissue Expansion MH - Tissue Expansion Devices KW - Acellular dermis; breast reconstruction; expander AB - OBJECTIVE: Although acellular dermis is widely used in prosthesis-based breast reconstruction, there is no study evaluating its expandability and histological, ultra-structural related changes. The purpose of this study is to determine whether acellular dermis could be expanded and whether the histological changes occurring in the skin with tissue expansion is different from normal when acellular dermis is used. AB - METHODS: Twenty-two male Wistar rats were used in this study. In group 1 (n=6), a rectangular-shaped tissue expander with final volume of 35ml was placed subcutaneously. In group 2 (n=6) tissue expander was placed submuscularly. In group 3 (n=6), a 4x5cm, acellular dermis was inserted and sutured in place, tissue expander was placed underneath acellular dermis. Group 4 (n=4) was control, no procedure was done after creation of a pocket. After day 30, tissue expanders were inflated with 2ml every 2 days with saline solution. On day 66, midvertical, midhorizontal surface expansion measurements were recorded. Samples were examined macroscopically. Biopsies were taken from mid-point of the expanded full-thickness flap. Histological evaluation, total skin thickness, epidermal thickness, and the amount of vascularisation were measured. AB - RESULTS: There was no expansion noted on the acellular dermis; however, acellular dermis increased vascularity and decreased the thinning of the overlying skin and thickening of the epidermis when compared to other groups. AB - CONCLUSION: Acellular dermis use can be beneficial in implant-based breast reconstruction in terms of morbidity and its tissue support. ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.1080/2000656X.2016.1213734 PT - Journal Article ID - 10.1080/2000656X.2016.1213734 [doi] PP - ppublish LG - English EP - 20160819 DP - 2017 Jun EZ - 2016/08/20 06:00 DA - 2017/12/29 06:00 DT - 2016/08/20 06:00 YR - 2017 ED - 20171228 RD - 20171228 UP - 20171229 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=27540822 <11. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28917935 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kankam HKN AU - Hourston GJM AU - Fopp LJ AU - Benson JR AU - Benyon SL AU - Irwin MS AU - Agrawal A AU - Forouhi P AU - Malata CM FA - Kankam, Hadyn K N FA - Hourston, George J M FA - Fopp, Laura J FA - Benson, John R FA - Benyon, Sarah L FA - Irwin, Michael S FA - Agrawal, Amit FA - Forouhi, Parto FA - Malata, Charles M IN - Kankam, Hadyn K N. Cambridge University Medical School, Cambridge, UK. IN - Hourston, George J M. Cambridge University Medical School, Cambridge, UK. IN - Fopp, Laura J. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Benson, John R. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Postgraduate Medical Institute, Faculty of Health Sciences, Anglia Ruskin University, Cambridge & Chelmsford, UK. IN - Benyon, Sarah L. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Irwin, Michael S. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Agrawal, Amit. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Forouhi, Parto. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Malata, Charles M. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Postgraduate Medical Institute, Faculty of Health Sciences, Anglia Ruskin University, Cambridge & Chelmsford, UK. Electronic address: cmalata@hotmail.com. TI - Trends in post-mastectomy breast reconstruction types at a breast cancer tertiary referral centre before and after introduction of acellular dermal matrices. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 71(1):21-27, 2018 Jan AS - J Plast Reconstr Aesthet Surg. 71(1):21-27, 2018 Jan NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 71 IP - 1 PG - 21-27 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis/ut [Utilization] MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/td [Trends] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Perforator Flap MH - Radiotherapy, Adjuvant MH - Retrospective Studies MH - Tertiary Care Centers MH - Treatment Outcome KW - Acellular dermal matrix; Immediate breast reconstruction; Outcomes; Trends AB - BACKGROUND: Reconstructive breast surgery has continued to evolve over the last decade with a key change being the adoption of acellular dermal matrices (ADMs) as an adjunct for implant-based procedures. This retrospective observational study assesses the effect of ADMs on post-mastectomy reconstructive practice performed in a single institution. AB - METHODS: We conducted a review of all patients undergoing breast reconstruction at a University Teaching Hospital for an 18-month period before and after adopting ADMs. Demographic, procedural and complication data for these two cohorts were compared (chi² and Student's t-tests). AB - RESULTS: A total of 264 women (336 breasts), mean age 47.5 years, were identified: 137 before and 127 after the introduction of ADM. Implant-only reconstructions increased from 16% to 52% following the adoption of ADM (p < 0.01), whereas the proportion of both latissimus dorsi and deep inferior epigastric perforator flap reconstructions decreased significantly (31%-11% and 49%-34%, respectively, p < 0.01). The rate of early complications for the implant-only procedures was not significantly different with or without ADM (26% versus 20%, respectively, p = 0.44), despite there being no difference in the rate of adjuvant radiotherapy (22% versus 35%, respectively, p = 0.30). AB - CONCLUSIONS: This study showed that since ADM introduction to our centre, more breast reconstructions have been of the implant-only type with consequent reductions in the more complex and expensive autologous techniques. Implant-only procedures that incorporated ADM use had similar complication rates to those that did not. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30343-1 DO - https://dx.doi.org/10.1016/j.bjps.2017.08.016 PT - Journal Article PT - Observational Study ID - S1748-6815(17)30343-1 [pii] ID - 10.1016/j.bjps.2017.08.016 [doi] PP - ppublish PH - 2017/03/20 [received] PH - 2017/07/20 [revised] PH - 2017/08/14 [accepted] LG - English EP - 20170831 DP - 2018 Jan EZ - 2017/09/18 06:00 DA - 2017/12/23 06:00 DT - 2017/09/18 06:00 YR - 2018 ED - 20171222 RD - 20171222 UP - 20171226 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28917935 <12. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29176426 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Serrurier LCJ AU - Rayne S AU - Venter M AU - Benn CA FA - Serrurier, L Charles J FA - Rayne, Sarah FA - Venter, Marisse FA - Benn, Carol-Ann IN - Serrurier, L Charles J. University of the Witwatersrand and, Milpark Breast Care Centre of Excellence, Johannesburg, South Africa. TI - Reply: Direct-to-Implant Breast Reconstruction without the Use of an Acellular Dermal Matrix Is Cost Effective and Oncologically Safe. CM - Comment on: Plast Reconstr Surg. 2017 Dec;140(6):820e-821e; PMID: 28820815 CM - Comment on: Plast Reconstr Surg. 2017 Apr;139(4):809-817; PMID: 28350650 SO - Plastic & Reconstructive Surgery. 140(6):821e-822e, 2017 12 AS - Plast Reconstr Surg. 140(6):821e-822e, 2017 12 NJ - Plastic and reconstructive surgery VO - 140 IP - 6 PG - 821e-822e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Humans MH - *Mammaplasty ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003896 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000003896 [doi] ID - 00006534-201712000-00043 [pii] PP - ppublish LG - English DP - 2017 12 EZ - 2017/11/28 06:00 DA - 2017/12/19 06:00 DT - 2017/11/28 06:00 YR - 2017 ED - 20171218 RD - 20171218 UP - 20171219 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29176426 <13. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28820815 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Parisi D AU - Ciancio F AU - Portincasa A AU - Innocenti A FA - Parisi, Domenico FA - Ciancio, Francesco FA - Portincasa, Aurelio FA - Innocenti, Alessandro IN - Parisi, Domenico. Department of Plastic and Reconstructive Surgery, University of Foggia, Foggia, Italy Department of Plastic and Reconstructive Surgery, University of Bari, Foggia, Italy Department of Plastic and Reconstructive Surgery, University of Foggia, Foggia, Italy Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy. TI - Direct-to-Implant Breast Reconstruction without the Use of an Acellular Dermal Matrix Is Cost Effective and Oncologically Safe. CM - Comment in: Plast Reconstr Surg. 2017 Dec;140(6):821e-822e; PMID: 29176426 CM - Comment on: Plast Reconstr Surg. 2017 Apr;139(4):809-817; PMID: 28350650 SO - Plastic & Reconstructive Surgery. 140(6):820e-821e, 2017 12 AS - Plast Reconstr Surg. 140(6):820e-821e, 2017 12 NJ - Plastic and reconstructive surgery VO - 140 IP - 6 PG - 820e-821e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Breast Neoplasms/su [Surgery] MH - Humans MH - *Mammaplasty ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003836 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000003836 [doi] PP - ppublish LG - English DP - 2017 12 EZ - 2017/08/19 06:00 DA - 2017/12/19 06:00 DT - 2017/08/19 06:00 YR - 2017 ED - 20171218 RD - 20171218 UP - 20171219 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28820815 <14. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29166348 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Glasberg SB FA - Glasberg, Scot Bradley IN - Glasberg, Scot Bradley. New York, N.Y. From the Department of Plastic Surgery, Lenox Hill Hospital/Manhattan Eye, Ear, and Throat Hospital, Northwell Health System, Hofstra School of Medicine. TI - The Economics of Prepectoral Breast Reconstruction. [Review] SO - Plastic & Reconstructive Surgery. 140(6S Prepectoral Breast Reconstruction):49S-52S, 2017 Dec AS - Plast Reconstr Surg. 140(6S Prepectoral Breast Reconstruction):49S-52S, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6S Prepectoral Breast Reconstruction PG - 49S-52S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Ambulatory Surgical Procedures/ec [Economics] MH - Ambulatory Surgical Procedures/mt [Methods] MH - Analgesics, Opioid/ec [Economics] MH - Analgesics, Opioid/tu [Therapeutic Use] MH - *Breast Neoplasms/ec [Economics] MH - Breast Neoplasms/rh [Rehabilitation] MH - Breast Neoplasms/su [Surgery] MH - Contracture/pc [Prevention & Control] MH - Esthetics MH - Female MH - Humans MH - Length of Stay/ec [Economics] MH - *Mammaplasty/ec [Economics] MH - Mammaplasty/mt [Methods] MH - Mammaplasty/rh [Rehabilitation] MH - Operative Time MH - Pain, Postoperative/ec [Economics] MH - Pain, Postoperative/et [Etiology] MH - Pain, Postoperative/pc [Prevention & Control] MH - Patient Satisfaction MH - Postoperative Complications/ec [Economics] MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Range of Motion, Articular/ph [Physiology] MH - Reoperation MH - Return to Work MH - Tissue Expansion/ec [Economics] MH - Tissue Expansion/sn [Statistics & Numerical Data] AB - The world of breast reconstruction over the last several years has seen a dramatic shift in focus to discussion and the application of placing tissue expanders and implants back into the prepectoral space. Although this technique failed during the early advent of breast reconstruction, newer technologies such as advances in fat grafting, improved acellular dermal matrices, better methods of assessing breast flap viability, and enhanced implants appear to have set the stage for the resurgence and positive early results seen with this technique. The main benefits of a switch to prepectoral breast reconstruction clinically appears to be less associated pain, lower incidence of animation deformities, and its associated symptoms as well as presumably better aesthetics. Early data suggest that the results are extremely promising and early adopters have attempted to define the ideal patients for prepectoral breast reconstruction. As with any new operative procedure, an assessment of finances and costs are crucial to its successful implementation. Although current data are minimal, this article attempts to build the fundamentals of an economic model that exhibits and displays potential savings through the use of prepectoral breast reconstruction. RN - 0 (Analgesics, Opioid) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004051 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000004051 [doi] ID - 00006534-201712001-00010 [pii] PP - ppublish LG - English DP - 2017 Dec EZ - 2017/11/23 06:00 DA - 2017/12/05 06:00 DT - 2017/11/23 06:00 YR - 2017 ED - 20171204 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29166348 <15. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29166346 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sigalove S FA - Sigalove, Steven IN - Sigalove, Steven. Warrenville, Ill. From the Institute of Aesthetic Plastic Surgery and Cantera Spa. TI - Options in Acellular Dermal Matrix-Device Assembly. [Review] SO - Plastic & Reconstructive Surgery. 140(6S Prepectoral Breast Reconstruction):39S-42S, 2017 Dec AS - Plast Reconstr Surg. 140(6S Prepectoral Breast Reconstruction):39S-42S, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6S Prepectoral Breast Reconstruction PG - 39S-42S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - Prepectoral prosthetic breast reconstruction has become increasingly popular during the last several years. Original shortcomings and poor outcomes in the 1970s have been overcome with the use of the bioengineered breast concept-namely, use of improved form stable breast implants, autologous fat grafting, and acellular dermal matrices (ADMs). Careful use of these reconstructive tools combined with improved mastectomy skin flaps has lead to successful early outcomes. Prepectoral breast reconstruction mitigates the animation deformities and muscle tightness previously associated with dual-plane prosthetic breast reconstruction while at the same time producing reproducible and outstanding aesthetic outcomes. The use of ADM is a critical component to performing prepectoral breast reconstruction. There are many techniques utilized to inset the ADM. Various methods of direct in vivo inset have been performed. These techniques are employed following completion of the mastectomy and are performed with both 2-stage as well as single-stage direct-to-implant reconstruction. Various ex vivo techniques have also been used for prepectoral breast reconstruction. Various prefabricated constructs of ADM and implant/tissue expander can be created on the back table while the mastectomy is in progress, which decreases operative time and improves surgical efficiency. This article will describe briefly the history of prepectoral reconstruction as well as describing the various techniques used for creating the ADM-device interphase. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004049 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000004049 [doi] ID - 00006534-201712001-00008 [pii] PP - ppublish LG - English DP - 2017 Dec EZ - 2017/11/23 06:00 DA - 2017/12/05 06:00 DT - 2017/11/23 06:00 YR - 2017 ED - 20171204 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29166346 <16. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29166345 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jones G AU - Yoo A AU - King V AU - Jao B AU - Wang H AU - Rammos C AU - Elwood E FA - Jones, Glyn FA - Yoo, Aran FA - King, Victor FA - Jao, Brian FA - Wang, Huaping FA - Rammos, Charalambos FA - Elwood, Eric IN - Jones, Glyn. Peoria, Ill.; and Boston, Mass. From the University of Illinois College of Medicine; University of Massachusetts; and Illinois Plastic Surgery. TI - Prepectoral Immediate Direct-to-Implant Breast Reconstruction with Anterior AlloDerm Coverage. SO - Plastic & Reconstructive Surgery. 140(6S Prepectoral Breast Reconstruction):31S-38S, 2017 Dec AS - Plast Reconstr Surg. 140(6S Prepectoral Breast Reconstruction):31S-38S, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6S Prepectoral Breast Reconstruction PG - 31S-38S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adipose Tissue/tr [Transplantation] MH - Adult MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Drainage/mt [Methods] MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Surgical Flaps MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - BACKGROUND: Staged subpectoral expander-implant breast reconstruction is widely performed. Disruption of the pectoralis major origin and the frequent occurrence of animation deformity and functional discomfort associated with subpectoral reconstruction remain ongoing concerns. Prepectoral single-stage direct-to-implant reconstruction resolves many of these issues. In this study, the authors explored the rationale for prepectoral single-stage implant-based breast reconstruction with anterior AlloDerm coverage as an alternative to the staged approach. AB - METHODS: Seventy-three breasts in 50 patients were reconstructed using a single-stage direct-to-implant prepectoral approach with total anterior AlloDerm coverage during a 24-month period. The decision to proceed with single-stage reconstruction was predicated upon the adequacy of mastectomy skin flap blood flow based on indocyanine green fluorescence perfusion assessment. The patients were followed up for a maximum of 32 months. AB - RESULTS: Ninety-seven percent of patients achieved complete healing within 8 weeks. There were 2 implant losses (2.7%) due to infection. Major seroma rate requiring repeated aspiration and drain insertion was 1.2%. There were no full-thickness skin losses. Capsular contracture was 0% in nonradiated patients. There were no cases of animation deformity. The authors were unable to establish significant correlation between complications and any of the usually stated risk factors, such as smoking, obesity, and large mastectomy weights, presumably due to the rigorous application of intraoperative skin perfusion assessment. AB - CONCLUSION: Single-stage direct-to-implant reconstruction using a prepectoral approach appears to be a safe and effective means of breast reconstruction in many patients, assuming adequate skin perfusion is present. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004048 PT - Journal Article ID - 10.1097/PRS.0000000000004048 [doi] ID - 00006534-201712001-00007 [pii] PP - ppublish LG - English DP - 2017 Dec EZ - 2017/11/23 06:00 DA - 2017/12/05 06:00 DT - 2017/11/23 06:00 YR - 2017 ED - 20171204 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29166345 <17. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29166344 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY AU - Cocilovo C FA - Nahabedian, Maurice Y FA - Cocilovo, Costanza IN - Nahabedian, Maurice Y. Washington, DC; and Falls Church, VA From the Georgetown University Hospital and Inova Fairfax Hospital. TI - Two-Stage Prosthetic Breast Reconstruction: A Comparison Between Prepectoral and Partial Subpectoral Techniques. SO - Plastic & Reconstructive Surgery. 140(6S Prepectoral Breast Reconstruction):22S-30S, 2017 Dec AS - Plast Reconstr Surg. 140(6S Prepectoral Breast Reconstruction):22S-30S, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6S Prepectoral Breast Reconstruction PG - 22S-30S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Anti-Bacterial Agents/tu [Therapeutic Use] MH - Body Mass Index MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/lj [Legislation & Jurisprudence] MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/is [Instrumentation] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Care/mt [Methods] MH - Prospective Studies MH - Retrospective Studies AB - BACKGROUND: Prosthetic breast reconstruction with prepectoral placement may confer clinical advantages compared with subpectoral placement. The purpose of this study was to assess and compare clinical outcomes following 2-stage reconstruction following prepectoral and partial subpectoral placement of tissue expanders and implants. AB - METHODS: A retrospective review of 39 (prepectoral) and 50 (partial subpectoral) patients was completed. Acellular dermal matrix was used in all patients. Mean age was 50.4 and 49.2 years, respectively. Body mass index (BMI) > 30 was noted in 15.4% of prepectoral and 18% of partial subpectoral patients. Radiation therapy was delivered to 38.5% of prepectoral patients and to 22% of partial subpectoral patients. Mean follow-up was 8.7 and 13 months for the prepectoral cohort and partial subpectoral cohorts. AB - RESULTS: The percentage of patients having at least 1 adverse event was 20.5% in the prepectoral and 22% in the partial subpectoral cohorts. The incidence of surgical-site infection and seroma was 8.1% and 4.8%, respectively, for the prepectoral cohort and 4.8% and 2.4%, respectively, for the partial subpectoral cohorts. Device explantation was 6.5% for the prepectoral and 7.2% for the partial subpectoral patients. Explantation did not occur in patients who had radiation or who had a BMI > 30. Four patients (6 breasts-7.2%) required conversion from partial subpectoral to prepectoral because of animation deformity. AB - CONCLUSIONS: Prepectoral reconstruction is a viable alternative to partial subpectoral reconstruction. Proper patient selection is an important variable. Prepectoral reconstruction can be safely performed in patients with a BMI < 40 and in patients having postmastectomy radiation therapy. RN - 0 (Anti-Bacterial Agents) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004047 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0000000000004047 [doi] ID - 00006534-201712001-00006 [pii] PP - ppublish LG - English DP - 2017 Dec EZ - 2017/11/23 06:00 DA - 2017/12/05 06:00 DT - 2017/11/23 06:00 YR - 2017 ED - 20171204 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29166344 <18. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29166342 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H FA - Sbitany, Hani IN - Sbitany, Hani. San Francisco, Calif. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco. TI - Important Considerations for Performing Prepectoral Breast Reconstruction. [Review] SO - Plastic & Reconstructive Surgery. 140(6S Prepectoral Breast Reconstruction):7S-13S, 2017 Dec AS - Plast Reconstr Surg. 140(6S Prepectoral Breast Reconstruction):7S-13S, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6S Prepectoral Breast Reconstruction PG - 7S-13S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Intraoperative Care/mt [Methods] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/ae [Adverse Effects] MH - Patient Care Team MH - Patient Selection MH - Surgery, Plastic/mt [Methods] MH - Surgical Flaps/ae [Adverse Effects] AB - Prepectoral breast reconstruction has emerged as an excellent technique for postmastectomy reconstruction, as it allows for full preservation of a patient's pectoralis major muscle and chest wall function. This reduces pain, eliminates animation deformity, and results in high patient satisfaction. Safely performed prepectoral breast reconstruction requires a careful patient selection process before committing to the procedure, taking into account comorbidities, radiation status, and oncologic criteria such as tumor location and breast cancer stage. Furthermore, a thorough intraoperative assessment of mastectomy skin flaps is critical, with careful and precise confirmation that the skin is viable and well perfused, prior to proceeding with prepectoral breast reconstruction. This can be done both clinically and with perfusion assessment devices. The use of acellular dermal matrix (ADM) has enhanced outcomes and aesthetics of prepectoral reconstruction, by providing implant coverage and soft-tissue support. The ADM also adds the benefit of reducing capsular contracture rates and offers full control over the aesthetic definition of the newly reconstructed breast pocket. Aesthetic enhancement of results requires routine use of oversizing implants in the skin envelope, careful selection of full capacity or cohesive gel implants, and autologous fat grafting. In this way, patients in all clinical scenarios can benefit from the full muscle-sparing technique of prepectoral breast reconstruction, including those undergoing immediate reconstruction, delayed reconstruction, and delayed conversion from a subpectoral to prepectoral plane to correct animation deformity. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004045 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000004045 [doi] ID - 00006534-201712001-00004 [pii] PP - ppublish LG - English DP - 2017 Dec EZ - 2017/11/23 06:00 DA - 2017/12/05 06:00 DT - 2017/11/23 06:00 YR - 2017 ED - 20171204 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29166342 <19. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28806288 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sorkin M AU - Qi J AU - Kim HM AU - Hamill JB AU - Kozlow JH AU - Pusic AL AU - Wilkins EG FA - Sorkin, Michael FA - Qi, Ji FA - Kim, Hyungjin M FA - Hamill, Jennifer B FA - Kozlow, Jeffrey H FA - Pusic, Andrea L FA - Wilkins, Edwin G IN - Sorkin, Michael. Ann Arbor, Mich.; and New York, N.Y. From the Section of Plastic Surgery, Department of Surgery, and the Center for Statistical Consultation and Research, Department of Biostatistics, University of Michigan; and Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center. TI - Acellular Dermal Matrix in Immediate Expander/Implant Breast Reconstruction: A Multicenter Assessment of Risks and Benefits. SO - Plastic & Reconstructive Surgery. 140(6):1091-1100, 2017 Dec AS - Plast Reconstr Surg. 140(6):1091-1100, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6 PG - 1091-1100 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation/is [Instrumentation] MH - Breast Implantation/mt [Methods] MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Canada MH - Cohort Studies MH - Female MH - Humans MH - *Mammaplasty/is [Instrumentation] MH - Mammaplasty/mt [Methods] MH - *Mastectomy/is [Instrumentation] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Patient Satisfaction MH - Postoperative Complications/et [Etiology] MH - Prospective Studies MH - Risk Factors MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion/mt [Methods] MH - *Tissue Expansion Devices MH - Treatment Outcome MH - United States AB - BACKGROUND: Acellular dermal matrix has gained widespread acceptance in immediate expander/implant reconstruction because of perceived benefits, including improved expansion dynamics and superior aesthetic results. Although previous investigators have evaluated its risks, few studies have assessed the impact of acellular dermal matrix on other outcomes, including patient-reported measures. AB - METHODS: The Mastectomy Reconstruction Outcomes Consortium Study used a prospective cohort design to evaluate patients undergoing postmastectomy reconstruction from 10 centers and 58 participating surgeons between 2012 and 2015. The analysis focused on women undergoing immediate tissue expander reconstruction following mastectomies for cancer treatment or prophylaxis. Medical records and patient-reported outcome data, using the BREAST-Q and Numeric Pain Rating Scale instruments, were reviewed. Bivariate analyses and mixed-effects regression models were applied. AB - RESULTS: A total of 1297 patients were evaluated, including 655 (50.5 percent) with acellular dermal matrix and 642 (49.5 percent) without acellular dermal matrix. Controlling for demographic and clinical covariates, no significant differences were seen between acellular dermal matrix and non-acellular dermal matrix cohorts in overall complications (OR, 1.21; p = 0.263), major complications (OR, 1.43; p = 0.052), wound infections (OR, 1.49; p = 0.118), or reconstructive failures (OR, 1.55; p = 0.089) at 2 years after reconstruction. There were also no significant differences between the cohorts in the time to expander/implant exchange (p = 0.78). No significant differences were observed in patient-reported outcome scores, including satisfaction with breasts, psychosocial well-being, sexual well-being, physical well-being, and postoperative pain. AB - CONCLUSIONS: In this multicenter, prospective analysis, the authors found no significant acellular dermal matrix effects on complications, time to exchange, or patient-reported outcome in immediate expander/implant breast reconstruction. Further studies are needed to develop criteria for more selective use of acellular dermal matrix in these patients. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003842 PT - Evaluation Studies PT - Journal Article PT - Multicenter Study ID - 10.1097/PRS.0000000000003842 [doi] ID - PMC5705287 [pmc] ID - NIHMS894398 [mid] PP - ppublish GI - No: R01 CA152192 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2017 Dec PQ - 2018/12/01 EZ - 2017/08/15 06:00 DA - 2017/12/05 06:00 DT - 2017/08/15 06:00 YR - 2017 ED - 20171204 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28806288 <20. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29068954 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Pittman TA FA - Pittman, Troy A IN - Pittman, Troy A. Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Road, NW, 1st Floor PHC, Washington, D.C. 20007, troy.a.pittman@gunet.georgetown.edu. TI - Reply: Comparison of Different Acellular Dermal Matrices in Breast Reconstruction: The 50/50 Study. CM - Comment on: Plast Reconstr Surg. 2017 Mar;139(3):521-528; PMID: 28234811 CM - Comment on: Plast Reconstr Surg. 2017 Nov;140(5):750e-751e; PMID: 29068953 SO - Plastic & Reconstructive Surgery. 140(5):751e, 2017 11 AS - Plast Reconstr Surg. 140(5):751e, 2017 11 NJ - Plastic and reconstructive surgery VO - 140 IP - 5 PG - 751e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Humans MH - *Mammaplasty ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003807 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000003807 [doi] ID - 00006534-201711000-00045 [pii] PP - ppublish LG - English DP - 2017 11 EZ - 2017/10/27 06:00 DA - 2017/11/29 06:00 DT - 2017/10/26 06:00 YR - 2017 ED - 20171120 RD - 20171128 UP - 20171129 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=29068954 <21. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28032164 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Accurso A AU - Rocco N AU - Accardo G AU - Reale P AU - Salerno C AU - Mattera E AU - D'Andrea F AI - Rocco, Nicola; ORCID: http://orcid.org/0000-0001-6941-7873 FA - Accurso, Antonello FA - Rocco, Nicola FA - Accardo, Giuseppe FA - Reale, Paola FA - Salerno, Carmela FA - Mattera, Edi FA - D'Andrea, Francesco IN - Accurso, Antonello. Department of Surgery, Breast Unit, University Hospital "Federico II", Naples, Italy. IN - Rocco, Nicola. Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via S. Pansini 5, 80131, Naples, Italy. nicolarocco2003@gmail.com. IN - Accardo, Giuseppe. Department of Surgery, Breast Unit, University Hospital "Federico II", Naples, Italy. IN - Reale, Paola. Department of Surgery, Breast Unit, University Hospital "Federico II", Naples, Italy. IN - Salerno, Carmela. Department of Surgery, Breast Unit, University Hospital "Federico II", Naples, Italy. IN - Mattera, Edi. Department of Clinical and Experimental Medicine Flaviano Magrassi, Clinical Medicine Hospital Unit, Ambulatory of Vulnology, Second University of Naples, Naples, Italy. IN - D'Andrea, Francesco. Department of Plastic and Reconstructive Surgery, University of Naples "Federico II", Naples, Italy. TI - Innovative Management of Implant Exposure in ADM/Implant-Based Breast Reconstruction with Negative Pressure Wound Therapy. [Review] SO - Aesthetic Plastic Surgery. 41(1):36-39, 2017 Feb AS - Aesthetic Plast Surg. 41(1):36-39, 2017 Feb NJ - Aesthetic plastic surgery VO - 41 IP - 1 PG - 36-39 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Device Removal MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - *Negative-Pressure Wound Therapy/mt [Methods] MH - Postoperative Period MH - *Prosthesis Failure MH - Reoperation/mt [Methods] MH - Surgical Wound Infection/di [Diagnosis] MH - *Surgical Wound Infection/su [Surgery] MH - Wound Healing/ph [Physiology] KW - A cellular dermal matrix; Breast reconstruction; Implant exposure; Negative pressure wound therapy AB - INTRODUCTION: One-stage implant-based breast reconstruction has been recently improved by the introduction of biological [acellular dermal matrix (ADM)] and synthetic meshes. Advantages of ADMs in implant-based breast reconstruction derive from the expansion of the space available for the direct positioning of an implant, but their use could be associated with several complications. Although the majority of complications can be easily managed, mistakes in dealing with the first clinical signs of a potential adverse event can lead to implant loss. AB - CASE PRESENTATION: We report a case of ADM/implant exposure following NAC-sparing mastectomy and immediate implant-based reconstruction, successfully managed with an innovative staged treatment using negative pressure wound therapy, which allowed a rapid re-positioning of the prosthesis after complete clearance of bacteria from the implant pocket. AB - DISCUSSION: The safest strategy to manage implant exposure and concomitant bacterial growth is reported to be implant removal and delayed re-positioning after several months, following prolonged targeted antibiotic therapy. Our case shows how a short-time implant re-positioning following implant removal for implant exposure could be successfully pursued thanks to the shrewd use of negative pressure wound therapy with great advantages in terms of patient satisfaction and post-operative quality of life, offering women experiencing this complication the option of not delaying reconstruction for months after resolution of the complication, potentially avoiding major surgical procedures such as autologous tissue reconstructions. AB - LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-016-0739-1 PT - Case Reports PT - Journal Article PT - Review ID - 10.1007/s00266-016-0739-1 [doi] ID - 10.1007/s00266-016-0739-1 [pii] PP - ppublish PH - 2016/08/17 [received] PH - 2016/11/06 [accepted] LG - English EP - 20161228 DP - 2017 Feb EZ - 2016/12/30 06:00 DA - 2017/11/29 06:00 DT - 2016/12/30 06:00 YR - 2017 ED - 20171120 RD - 20171128 UP - 20171129 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=28032164 <22. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26663848 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Luo X AU - Kulig KM AU - Finkelstein EB AU - Nicholson MF AU - Liu XH AU - Goldman SM AU - Vacanti JP AU - Grottkau BE AU - Pomerantseva I AU - Sundback CA AU - Neville CM FA - Luo, Xiao FA - Kulig, Katherine M FA - Finkelstein, Eric B FA - Nicholson, Margaret F FA - Liu, Xiang-Hong FA - Goldman, Scott M FA - Vacanti, Joseph P FA - Grottkau, Brian E FA - Pomerantseva, Irina FA - Sundback, Cathryn A FA - Neville, Craig M IN - Luo, Xiao. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Luo, Xiao. Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 434300, People's Republic of China. IN - Kulig, Katherine M. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Finkelstein, Eric B. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Finkelstein, Eric B. The Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, Syracuse, New York, 13244. IN - Nicholson, Margaret F. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Liu, Xiang-Hong. DSM Biomedical, Exton, Pennysylvania, 19341. IN - Goldman, Scott M. DSM Biomedical, Exton, Pennysylvania, 19341. IN - Vacanti, Joseph P. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Vacanti, Joseph P. Harvard Medical School, Boston, Massachusetts, 02115. IN - Grottkau, Brian E. Harvard Medical School, Boston, Massachusetts, 02115. IN - Grottkau, Brian E. Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Pomerantseva, Irina. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Pomerantseva, Irina. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Pomerantseva, Irina. Harvard Medical School, Boston, Massachusetts, 02115. IN - Sundback, Cathryn A. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Sundback, Cathryn A. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Sundback, Cathryn A. Harvard Medical School, Boston, Massachusetts, 02115. IN - Neville, Craig M. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Neville, Craig M. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114. IN - Neville, Craig M. Harvard Medical School, Boston, Massachusetts, 02115. IN - Neville, Craig M. Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, 02114. TI - In vitro evaluation of decellularized ECM-derived surgical scaffold biomaterials. SO - Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 105(3):585-593, 2017 04 AS - J Biomed Mater Res B Appl Biomater. 105(3):585-593, 2017 04 NJ - Journal of biomedical materials research. Part B, Applied biomaterials VO - 105 IP - 3 PG - 585-593 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101234238 IO - J. Biomed. Mater. Res. Part B Appl. Biomater. SB - Index Medicus CP - United States MH - Animals MH - Apoptosis MH - Cattle MH - *Cell Proliferation MH - *Chemotaxis MH - *Dermis/ch [Chemistry] MH - *Extracellular Matrix/ch [Chemistry] MH - *Fibroblasts/me [Metabolism] MH - Humans MH - Mice MH - NIH 3T3 Cells MH - *Signal Transduction MH - Swine MH - *Tissue Scaffolds/ch [Chemistry] KW - *cell adhesion; *cell proliferation; *extracellular matrix; *in vitro; *scaffolds AB - Decellularized extracellular matrix (ECM) biomaterials are increasingly used in regenerative medicine for abdominal tissue repair. Emerging ECM biomaterials with greater compliance target surgical procedures like breast and craniofacial reconstruction to enhance aesthetic outcome. Clinical studies report improved outcomes with newly designed ECM scaffolds, but their comparative biological characteristics have received less attention. In this study, we investigated scaffolds derived from dermis (AlloDerm Regenerative Tissue Matrix), small intestinal submucosa (Surgisis 4-layer Tissue Graft and OASIS Wound Matrix), and mesothelium (Meso BioMatrix Surgical Mesh and Veritas Collagen Matrix) and evaluated biological properties that modulate cellular responses and recruitment. An assay panel was utilized to assess the ECM scaffold effects upon cells. Results of the material-conditioned media study demonstrated Meso BioMatrix and OASIS best supported cell proliferation. Meso BioMatrix promoted the greatest migration and chemotaxis signaling, followed by Veritas and OASIS; OASIS had superior suppression of cell apoptosis. The direct adhesion assay indicated that AlloDerm, Meso BioMatrix, Surgisis, and Veritas had sidedness that affected cell-material interactions. In the chick chorioallantoic membrane assay, Meso BioMatrix and OASIS best supported cell infiltration. Among tested materials, Meso BioMatrix and OASIS demonstrated characteristics that facilitate scaffold incorporation, making them promising choices for many clinical applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 585-593, 2017. Copyright © 2015 Wiley Periodicals, Inc. ES - 1552-4981 IL - 1552-4973 DO - https://dx.doi.org/10.1002/jbm.b.33572 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1002/jbm.b.33572 [doi] PP - ppublish PH - 2015/06/24 [received] PH - 2015/10/19 [revised] PH - 2015/11/02 [accepted] LG - English EP - 20151210 DP - 2017 04 EZ - 2015/12/15 06:00 DA - 2017/11/29 06:00 DT - 2015/12/15 06:00 YR - 2017 ED - 20171120 RD - 20171226 UP - 20171226 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=26663848 <23. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28953753 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Oh C AU - Winocour S AU - Lemaine V FA - Oh, Christine FA - Winocour, Sebastian FA - Lemaine, Valerie IN - Oh, Christine. Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minn. Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minn. TI - Acellular Dermal Matrix in Submuscular Implant-Based Breast Reconstruction: A Novel Technique to Improve Symmetry. CM - Comment on: Plast Reconstr Surg Glob Open. 2016 May 04;4(5):e698; PMID: 27579223 SO - Plastic & Reconstructive Surgery. 140(4):641e-643e, 2017 10 AS - Plast Reconstr Surg. 140(4):641e-643e, 2017 10 NJ - Plastic and reconstructive surgery VO - 140 IP - 4 PG - 641e-643e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003738 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000003738 [doi] ID - 00006534-201710000-00067 [pii] PP - ppublish LG - English DP - 2017 10 EZ - 2017/09/28 06:00 DA - 2017/09/28 06:01 DT - 2017/09/28 06:00 YR - 2017 ED - 20171117 RD - 20171128 UP - 20171129 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28953753 <24. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28273056 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Roh DS AU - Treiser MD AU - Lafleur EH AU - Chun YS FA - Roh, Daniel S FA - Treiser, Matthew D FA - Lafleur, Emily H FA - Chun, Yoon S IN - Roh, Daniel S. From the *Harvard Combined Plastic Surgery Residency Program; and +Division of Plastic Surgery, Brigham & Women's Hospital, Boston, MA. TI - Technique to Promote Symmetry in 2-Staged Bilateral Breast Reconstruction in the Setting of Unilateral Postmastectomy Radiation. SO - Annals of Plastic Surgery. 78(4):386-391, 2017 Apr AS - Ann Plast Surg. 78(4):386-391, 2017 Apr NJ - Annals of plastic surgery VO - 78 IP - 4 PG - 386-391 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - *Esthetics MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Radiotherapy, Adjuvant MH - Retrospective Studies MH - Risk Assessment MH - Treatment Outcome MH - *Wound Healing/ph [Physiology] AB - BACKGROUND: Bilateral breast reconstruction in the setting of unilateral postmastectomy radiation therapy (PMRT) remains one of the most difficult reconstructive challenges due to significant radiation-induced asymmetry from capsular contracture and superior migration of the irradiated reconstructed breast. We describe a novel and straightforward intraoperative technique for creating compensatory asymmetry to maximize postradiation symmetry in immediate bilateral tissue expander (TE) and acellular dermal matrix (ADM) reconstruction requiring unilateral PMRT. AB - METHODS: A cohort of 25 bilateral TE/ADM breast reconstructions with planned unilateral PMRT was performed using this approach, and outcomes were reviewed. On the PMRT side, the ADM edge was inset to a lower inframammary fold (IMF) position resulting in a near "bottoming-out" effect. On the non-PMRT side, the ADM was inset using a triple point stitch onto the IMF in a higher chest wall location. The planned PMRT side TE was overexpanded and second-stage exchanges were performed 6+ months post-PMRT. AB - RESULTS: Post-PMRT results showed improved symmetry as the PMRT side migrated superiorly to match the contralateral non-irradiated side. Minimal pocket or IMF adjustments were required during second-stage procedures, with just 6 patients (24%) requiring minor lowering and 1 patient (4%) requiring elevation of the PMRT side IMF. Thus, most (72%) patients undergoing bilateral mastectomy and unilateral PMRT did not require any IMF modifications during the second-stage procedure. AB - CONCLUSIONS: A differential ADM inset and TE pocket creation for bilateral TE/ADM breast reconstructions with planned unilateral PMRT can minimize the typical adverse aesthetic effects of PMRT on reconstruction results and maximize symmetry. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000892 PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0000000000000892 [doi] ID - 00000637-201704000-00006 [pii] PP - ppublish LG - English DP - 2017 Apr EZ - 2017/03/09 06:00 DA - 2017/11/10 06:00 DT - 2017/03/09 06:00 YR - 2017 ED - 20171109 RD - 20171109 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28273056 <25. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27524677 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chopra K AU - Buckingham B AU - Matthews J AU - Sabino J AU - Tadisina KK AU - Silverman RP AU - Goldberg NH AU - Slezak S AU - Singh DP FA - Chopra, Karan FA - Buckingham, Bryan FA - Matthews, Jamil FA - Sabino, Jennifer FA - Tadisina, Kashyap K FA - Silverman, Ronald P FA - Goldberg, Nelson H FA - Slezak, Sheri FA - Singh, Devinder P IN - Chopra, Karan. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Chopra, Karan. Department of Plastic & Reconstructive Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA. IN - Buckingham, Bryan. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Matthews, Jamil. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Sabino, Jennifer. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Tadisina, Kashyap K. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Silverman, Ronald P. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Goldberg, Nelson H. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Slezak, Sheri. Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. IN - Singh, Devinder P. Department of Plastic Surgery, Anne Arundel Medical Center, Annapolis, MD, USA. TI - Acellular dermal matrix reduces capsule formation in two-stage breast reconstruction. SO - International Wound Journal. 14(2):414-419, 2017 Apr AS - Int Wound J. 14(2):414-419, 2017 Apr NJ - International wound journal VO - 14 IP - 2 PG - 414-419 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101230907 IO - Int Wound J SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - *Breast Implants MH - *Breast Neoplasms/rh [Rehabilitation] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Time Factors MH - *Tissue Expansion Devices MH - Wound Healing KW - Capsule formation; Human acellular dermal matrix; Two-stage breast reconstruction AB - Acellular dermal matrix (ADM) is commonly employed to create an inferior pocket for the tissue expander in two-stage breast reconstruction. The authors sought to determine whether placement of ADM during the first stage of reconstruction decreases the amount of capsule formation at implant exchange. Patients who underwent mastectomy and tissue expander reconstruction were included in this study. Two biopsies were obtained at the time of implant exchange, one from the pocket adjacent to the ADM and the other from the area adjacent to the pectoralis muscle. Pathology analysis was performed on each sample. Ten patients underwent immediate breast reconstruction with Alloderm during the 3-month study period. Capsule thickness was significantly greater in the areas where the expander was in direct contact with the pectoralis muscle (782 +/- 194 micro m) compared to those in contact with human acellular dermal matrix (hADM) (47.91 +/- 110.82 micro m; P < 0.05). Analysis of the sub-pectoral capsule demonstrated diffuse deposition of collagen, neutrophils, contractile myofibroblasts and synovia-like metaplasia, characteristic of a foreign body response. Conversely, within the inferior pocket where the hADM was in direct contact with the expander, we noted migration of host epithelial cells, fibroblasts, mesenchymal cells and angiogenesis, indicating host tissue regeneration. Acellular dermal matrix, when placed at the first stage of breast reconstruction, significantly reduces thickness and inflammatory character of the capsule in comparison to the patient's native tissue. Copyright © 2016 Medicalhelplines.com Inc and John Wiley & Sons Ltd. RN - 9007-34-5 (Collagen) ES - 1742-481X IL - 1742-4801 DO - https://dx.doi.org/10.1111/iwj.12620 PT - Comparative Study PT - Journal Article ID - 10.1111/iwj.12620 [doi] PP - ppublish PH - 2016/01/25 [received] PH - 2016/04/18 [revised] PH - 2016/04/24 [accepted] LG - English EP - 20160815 DP - 2017 Apr EZ - 2016/08/16 06:00 DA - 2017/11/08 06:00 DT - 2016/08/16 06:00 YR - 2017 ED - 20171107 RD - 20171107 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27524677 <26. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28736191 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Onesti MG AU - Maruccia M AU - Di Taranto G AU - Albano A AU - Soda G AU - Ballesio L AU - Scuderi N FA - Onesti, Maria Giuseppina FA - Maruccia, Michele FA - Di Taranto, Giuseppe FA - Albano, Antonio FA - Soda, Giuseppe FA - Ballesio, Laura FA - Scuderi, Nicolo IN - Onesti, Maria Giuseppina. Department Surgery "P.Valdoni", Unit of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. IN - Maruccia, Michele. Department Surgery "P.Valdoni", Unit of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. Electronic address: marucciam@gmail.com. IN - Di Taranto, Giuseppe. Department Surgery "P.Valdoni", Unit of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. IN - Albano, Antonio. Department Surgery "P.Valdoni", Unit of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. IN - Soda, Giuseppe. Department of Molecular medicine, Sapienza University of Rome, Rome, Italy. IN - Ballesio, Laura. Department of Radiological, Oncological, Anatomo-pathological Sciences, Sapienza University of Rome, Rome, Italy. IN - Scuderi, Nicolo. Department Surgery "P.Valdoni", Unit of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. TI - Clinical, histological, and ultrasound follow-up of breast reconstruction with one-stage muscle-sparing "wrap" technique: A single-center experience. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 70(11):1527-1536, 2017 Nov AS - J Plast Reconstr Aesthet Surg. 70(11):1527-1536, 2017 Nov NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 70 IP - 11 PG - 1527-1536 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Organ Sparing Treatments/mt [Methods] MH - *Patient Satisfaction MH - *Pectoralis Muscles/tr [Transplantation] MH - Prospective Studies MH - Surgical Flaps MH - Surveys and Questionnaires MH - Treatment Outcome KW - Acellular dermal matrix; Breast cancer; Breast reconstruction; Muscle-sparing technique; One-stage technique AB - BACKGROUND: Prepectoral implant placement and complete coverage with porcine acellular matrix after mastectomy is a new concept in breast surgery presented in few cases in the literature. This paper aimed to present our single-center experience in one-stage breast reconstruction muscle-sparing "wrap" technique by evaluating clinical and aesthetic outcomes, ultrasound and histological examination, and patient quality of life. AB - METHODS: From January 2014 to January 2017, 52 patients (40 unilateral, 12 bilateral) underwent one-stage muscle-sparing breast reconstructions with Braxon acellular dermal matrix and implant. In 3 patients, a surgical biopsy and histological examination with immunohistochemical analysis of the periprosthetic tissue were performed. All patients underwent breast ultrasound examination, and the occurrence of capsular contracture was assessed through the Baker classification and by measuring the mammary compliance scores with the Antoon Paar Mammary compliance system. Breast appearance was evaluated using a visual analogue scale (VAS) and in terms of quality of life using the EOCRT QLQ C-30 and QLQ BR-23 questionnaires. AB - RESULTS: Early and late postoperative complications are reported. Histological and ultrasound evaluation showed a complete integration of the matrix. According to the VAS scale, the EOCRT QLQ C-30, and QLQ BR-23, patients' satisfaction resulted in a high score in terms of quality of life and aesthetic outcomes. AB - CONCLUSION: The results of this new surgical technique in selected cases are promising in terms of effectiveness and low rate of postoperative complications, but further long-terms evaluations are required. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30269-3 DO - https://dx.doi.org/10.1016/j.bjps.2017.06.023 PT - Journal Article ID - S1748-6815(17)30269-3 [pii] ID - 10.1016/j.bjps.2017.06.023 [doi] PP - ppublish PH - 2017/01/15 [received] PH - 2017/05/02 [revised] PH - 2017/06/12 [accepted] LG - English EP - 20170629 DP - 2017 Nov EZ - 2017/07/25 06:00 DA - 2017/11/03 06:00 DT - 2017/07/25 06:00 YR - 2017 ED - 20171102 RD - 20171102 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28736191 <27. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29064921 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Colwell AS AU - Christensen JM FA - Colwell, Amy S FA - Christensen, Joani M IN - Colwell, Amy S. Boston, Mass. From the Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School. TI - Nipple-Sparing Mastectomy and Direct-to-Implant Breast Reconstruction. [Review] SO - Plastic & Reconstructive Surgery. 140(5S Advances in Breast Reconstruction):44S-50S, 2017 Nov AS - Plast Reconstr Surg. 140(5S Advances in Breast Reconstruction):44S-50S, 2017 Nov NJ - Plastic and reconstructive surgery VO - 140 IP - 5S Advances in Breast Reconstruction PG - 44S-50S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - *Nipples/su [Surgery] MH - Pain Management/mt [Methods] MH - Patient Selection MH - Postoperative Care/mt [Methods] AB - Breast reconstruction following mastectomy has evolved to preserve the native skin and nipple of the breast and create a natural-appearing reconstruction in 1 or 2 surgeries. Nipple-sparing procedures appear to be oncologically safe with low risks of cancer recurrence. In our series of 2,182 nipple-sparing mastectomies, there was no development or recurrence of cancer in the nipple. Direct-to-implant single-stage surgery offers the patient a complete reconstruction at the time of mastectomy. Patient selection centers on preoperative breast anatomy combined with postoperative goals for size and uplift of the breast. The best candidates for nipple-sparing mastectomy and direct-to-implant breast reconstruction include those with grade I-II breast ptosis and those desiring to stay approximately the same breast size. The choice of incision and width of the implant play key roles in nipple centralization. Partial muscle coverage with acellular dermal matrix remains the most common technique to support the implant and offers the advantage of more soft-tissue coverage in the upper pole. With experience, complications and revisions are similar in this approach compared with more traditional 2-stage tissue expander-implant reconstruction. Thus, nipple-sparing mastectomy and direct-to-implant breast reconstruction is emerging as a preferred method of breast reconstruction when the breast skin envelope is sufficiently perfused. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003949 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000003949 [doi] ID - 00006534-201711001-00008 [pii] PP - ppublish LG - English DP - 2017 Nov EZ - 2017/10/25 06:00 DA - 2017/10/31 06:00 DT - 2017/10/25 06:00 YR - 2017 ED - 20171030 RD - 20171030 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=29064921 <28. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29064920 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kim JYS AU - Mlodinow AS FA - Kim, John Y S FA - Mlodinow, Alexei S IN - Kim, John Y S. Chicago, Ill. From the Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine. TI - What's New in Acellular Dermal Matrix and Soft-Tissue Support for Prosthetic Breast Reconstruction. [Review] SO - Plastic & Reconstructive Surgery. 140(5S Advances in Breast Reconstruction):30S-43S, 2017 Nov AS - Plast Reconstr Surg. 140(5S Advances in Breast Reconstruction):30S-43S, 2017 Nov NJ - Plastic and reconstructive surgery VO - 140 IP - 5S Advances in Breast Reconstruction PG - 30S-43S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Skin Transplantation/mt [Methods] MH - *Surgical Mesh MH - *Tissue Scaffolds AB - Of the nearly 90,000 implant-based breast reconstructions performed in the United States, the majority use internal soft-tissue support. Aesthetically, these constructs may allow for better positioning of prosthesis, improve lower pole expansion, and increase projection. They may have particular utility in direct-to-implant, nipple-sparing mastectomies, and prepectoral reconstructions. In recent years, new permutations of acellular dermal matrices have evolved with diverse shapes, sizes, form-factor innovations, and processing characteristics. The literature is largely limited to retrospective studies (and meta-analyses thereof), making robust comparisons of 1 iteration vis-a-vis another difficult. Although synthetic mesh may provide a cost-effective alternative in primary and secondary reconstruction, comparative studies with acellular dermal matrix are lacking. This review aims to provide a balanced overview of recent biologic and synthetic mesh innovation. As this technology (and concomitant techniques) evolve, the reconstructive surgeon is afforded more-and better-choices to improve care for patients. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003950 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000003950 [doi] ID - 00006534-201711001-00007 [pii] PP - ppublish LG - English DP - 2017 Nov EZ - 2017/10/25 06:00 DA - 2017/10/31 06:00 DT - 2017/10/25 06:00 YR - 2017 ED - 20171030 RD - 20171030 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=29064920 <29. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27351474 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Momoh AO AU - Wilkins EG FA - Momoh, Adeyiza O FA - Wilkins, Edwin G IN - Momoh, Adeyiza O. Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich. TI - Reply: Use of Acellular Dermal Matrix in Postmastectomy Breast Reconstruction: Are All Acellular Dermal Matrices Created Equal?. CM - Comment on: Plast Reconstr Surg. 2016 Jul;138(1):148e-9e; PMID: 27351473 SO - Plastic & Reconstructive Surgery. 138(1):149e-50e, 2016 07 AS - Plast Reconstr Surg. 138(1):149e-50e, 2016 07 NJ - Plastic and reconstructive surgery VO - 138 IP - 1 PG - 149e-50e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Humans MH - *Mammaplasty ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002275 PT - Letter PT - Comment ID - 10.1097/PRS.0000000000002275 [doi] ID - 00006534-201607000-00066 [pii] PP - ppublish LG - English DP - 2016 07 EZ - 2016/06/29 06:00 DA - 2016/06/29 06:01 DT - 2016/06/29 06:00 YR - 2016 ED - 20171026 RD - 20171026 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27351474 <30. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27348677 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ranganathan K AU - Momoh AO FA - Ranganathan, Kavitha FA - Momoh, Adeyiza O IN - Ranganathan, Kavitha. Division of Plastic and Reconstructive Surgery, University of Michigan Health Systems, Ann Arbor, Mich. TI - Reply: Use of Acellular Dermal Matrix in Postmastectomy Breast Reconstruction: Are All Acellular Dermal Matrices Created Equal?. CM - Comment on: Plast Reconstr Surg. 2016 Jul;138(1):145e-6e; PMID: 27351472 CM - Comment on: Plast Reconstr Surg. 2015 Oct;136(4):654-6; PMID: 26397243 SO - Plastic & Reconstructive Surgery. 138(1):146e-7e, 2016 07 AS - Plast Reconstr Surg. 138(1):146e-7e, 2016 07 NJ - Plastic and reconstructive surgery VO - 138 IP - 1 PG - 146e-7e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Collagen MH - Humans MH - *Mammaplasty RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002272 PT - Letter PT - Comment ID - 10.1097/PRS.0000000000002272 [doi] ID - 00006534-201607000-00064 [pii] PP - ppublish LG - English DP - 2016 07 EZ - 2016/06/28 06:00 DA - 2016/06/28 06:01 DT - 2016/06/28 06:00 YR - 2016 ED - 20171026 RD - 20171026 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27348677 <31. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26849284 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hunsicker LM AU - Ashikari AY AU - Berry C AU - Koch RM AU - Salzberg CA FA - Hunsicker, Lisa M FA - Ashikari, Andrew Y FA - Berry, Colleen FA - Koch, R Michael FA - Salzberg, C Andrew IN - Hunsicker, Lisa M. From the *Revalla Plastic Surgery, Littleton, CO; +Ashikari Breast Center; and ++New York Group for Plastic Surgery, LLP, New York, NY. TI - Short-Term Complications Associated With Acellular Dermal Matrix-Assisted Direct-to-Implant Breast Reconstruction. SO - Annals of Plastic Surgery. 78(1):35-40, 2017 Jan AS - Ann Plast Surg. 78(1):35-40, 2017 Jan NJ - Annals of plastic surgery VO - 78 IP - 1 PG - 35-40 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast Implantation/mt [Methods] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Reoperation/sn [Statistics & Numerical Data] MH - Retrospective Studies MH - Risk Factors AB - BACKGROUND: Although direct-to-implant breast reconstruction is a more concise procedure than 2-stage expander/implant reconstruction, it is less frequently performed. Skeptics of direct-to-implant reconstruction cite risk of postoperative complications as a reason for its rejection. To determine whether these perceptions are valid, we evaluated our 13-year experience of acellular dermal matrix (ADM)-assisted, direct-to-implant breast reconstruction. We report complication and reoperation rates associated with this technique as well as predictors for these outcomes. AB - METHODS: This retrospective study included all patients who underwent immediate, ADM-assisted, direct-to-implant, breast reconstruction from December 2001 to May 2014 at 2 practices. Postoperative complications, defined as those occurring within the first 12 months after reconstructive surgery, were evaluated. Univariate/multivariate analyses were performed to determine the influence of patient-, breast-, and surgery-related characteristics on the development of complications. AB - RESULTS: A total of 1584 breast reconstructions (721 bilateral, 142 unilateral) in 863 patients were performed; 35% were oncologic, and 65% were prophylactic reconstructions. Complication rate was 8.6% and included skin necrosis (5.9%), infection (3.0%), implant loss (2.9%), seroma (1.1%), and hematoma (0.9%). Reoperative rate in breasts with complications was 3.2%. Age 50 years or older, smoking, nonnipple-sparing mastectomy, and implant size of 600 mL or greater strongly predicted the development of complications (P < 0.001). AB - CONCLUSIONS: Our cumulative 13-year experience demonstrates that immediate, ADM-assisted, direct-to-implant breast reconstruction is safe, effective, and reliable. Complication and reoperation rates are less than 10% and are comparable to those reported for 2-stage procedures in the published literature. ES - 1536-3708 IL - 0148-7043 PT - Journal Article ID - 10.1097/SAP.0000000000000742 [doi] PP - ppublish LG - English DP - 2017 Jan EZ - 2016/02/06 06:00 DA - 2017/10/05 06:00 DT - 2016/02/06 06:00 YR - 2017 ED - 20171004 RD - 20171004 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26849284 <32. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27220022 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Suri S AU - Bagiella E AU - Factor SH AU - Taub PJ FA - Suri, Simrat FA - Bagiella, Emilia FA - Factor, Stephanie H FA - Taub, Peter J IN - Suri, Simrat. From the Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, New York, NY. TI - Soft Tissue Adjuncts in Revisionary Aesthetic Breast Surgery. [Review] SO - Annals of Plastic Surgery. 78(2):230-235, 2017 Feb AS - Ann Plast Surg. 78(2):230-235, 2017 Feb NJ - Annals of plastic surgery VO - 78 IP - 2 PG - 230-235 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Outcome Assessment (Health Care) MH - *Reoperation/mt [Methods] AB - Reconstructive breast surgery is challenging and continually evolving. In the past decade, numerous soft tissue adjuncts, such as acellular dermal matrices (ADMs), have revolutionized breast reconstruction serving as a tool to improve results and minimize the need for revision. The use of ADMs has been widely discussed in primary and secondary breast reconstruction after mastectomy. They have been shown to be an effective and safe option to correct complications; however, there is a relative paucity of literature on their use in revisional surgery after aesthetic breast procedures. The authors queried PubMed for existing literature regarding the use of ADMs in secondary breast surgery. Five case series from an initial search of 278 articles met the inclusion criteria. An overall infection rate of 2% and a complication rate of implant malposition was 0.8% with the use of ADMs. Although the literature is sparse regarding their use in this setting, early reports indicate that they are both safe and efficacious with a reasonable rate of complications. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000835 PT - Journal Article PT - Review ID - 10.1097/SAP.0000000000000835 [doi] PP - ppublish LG - English DP - 2017 Feb EZ - 2016/05/25 06:00 DA - 2017/10/04 06:00 DT - 2016/05/25 06:00 YR - 2017 ED - 20171003 RD - 20171003 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27220022 <33. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27825422 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dong JY AU - Yan Y AU - Liu MF AU - Guo ZZ AU - Guo JY AU - Ye CS FA - Dong, Jian-Yu FA - Yan, Yan FA - Liu, Min-Feng FA - Guo, Zhao-Ze FA - Guo, Jing-Yun FA - Ye, Chang-Sheng IN - Dong, Jian-Yu. Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. IN - Yan, Yan. Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. IN - Liu, Min-Feng. Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. IN - Guo, Zhao-Ze. Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. IN - Guo, Jing-Yun. Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. IN - Ye, Chang-Sheng. Breast Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. TI - Use of Acellular Dermal Matrices in One-stage Implant-based Breast Reconstruction. [Review] SO - Chung-Kuo i Hsueh Ko Hsueh Yuan Hsueh Pao Acta Academiae Medicinae Sinicae. 38(5):607-610, 2016 10 10 AS - Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 38(5):607-610, 2016 10 10 NJ - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae VO - 38 IP - 5 PG - 607-610 PI - Journal available in: Print PI - Citation processed from: Print JC - czs, 8006230 IO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao SB - Index Medicus CP - China MH - *Acellular Dermis MH - *Breast Implantation MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mastectomy MH - Postoperative Complications AB - Implant-based breast reconstruction is the most common choice in breast cancer patients. Recently,the acellular dermal matrix (ADM) technique has been widely used in implant-based breast reconstruction in the western countries. This article briefly reviews the biological characteristics,history,types,surgical techniques,and postoperative complications of ADM. IS - 1000-503X IL - 1000-503X DO - https://dx.doi.org/10.3881/j.issn.1000-503X.2016.05.021 PT - Journal Article PT - Review ID - 10.3881/j.issn.1000-503X.2016.05.021 [doi] PP - ppublish LG - English DP - 2016 10 10 EZ - 2016/11/09 06:00 DA - 2017/09/28 06:00 DT - 2016/11/10 06:00 YR - 2016 ED - 20170927 RD - 20171106 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27825422 <34. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28591940 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tran BNN AU - Fadayomi A AU - Lin SJ AU - Singhal D AU - Lee BT AI - Lee, Bernard T; ORCID: http://orcid.org/0000-0002-5533-3166 FA - Tran, Bao Ngoc N FA - Fadayomi, Ayotunde FA - Lin, Samuel J FA - Singhal, Dhruv FA - Lee, Bernard T IN - Tran, Bao Ngoc N. Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Boston, Massachusetts. IN - Fadayomi, Ayotunde. Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Boston, Massachusetts. IN - Lin, Samuel J. Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Boston, Massachusetts. IN - Singhal, Dhruv. Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Boston, Massachusetts. IN - Lee, Bernard T. Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Boston, Massachusetts. TI - Cost analysis of postmastectomy reconstruction: A comparison of two staged implant reconstruction using tissue expander and acellular dermal matrix with abdominal-based perforator free flaps. SO - Journal of Surgical Oncology. 116(4):439-447, 2017 Sep AS - J Surg Oncol. 116(4):439-447, 2017 Sep NJ - Journal of surgical oncology VO - 116 IP - 4 PG - 439-447 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - k79, 0222643 IO - J Surg Oncol SB - Index Medicus CP - United States MH - *Acellular Dermis/ec [Economics] MH - Breast Implantation/ec [Economics] MH - Breast Implantation/mt [Methods] MH - *Breast Implants/ec [Economics] MH - Costs and Cost Analysis MH - Female MH - Humans MH - *Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Medicare/ec [Economics] MH - *Perforator Flap/ec [Economics] MH - Skin Transplantation/ec [Economics] MH - *Tissue Expansion/ec [Economics] MH - United States KW - *acellular dermal matrix; *cost analysis; *deep inferior epigastric perforator flap; *implant-based reconstruction AB - BACKGROUND AND OBJECTIVES: Two staged tissue expander-implant with acellular dermal matrix (TE/I+ADM) and deep inferior epigastric perforator (DIEP) flap are the most common implant and autologous methods of reconstruction in the U.S. Implant-based techniques are disproportionally more popular, partially due to its presumed cost effectiveness. We performed a comprehensive cost analysis to compare TE/I+ADM and DIEP flap. AB - METHODS: A comparative cost analysis of TE/I+ADM and DIEP flap was performed. Medicare reimbursement costs for each procedure and their associated complications were calculated. Pooled probabilities of complications including cellulitis, seroma, skin necrosis, implant removal, flap loss, partial flap loss, and fat necrosis, were calculated using published studies from 2010 to 2016. AB - RESULTS: Average actual cost for successful TE/I+ADM and DIEP flap were $13304.55 and $10237.13, respectively. Incorporating pooled complication data from published literature resulted in an increase in cost to $13963.46 for TE/I+ADM and $12624.29 for DIEP flap. The expected costs for successful TE/I+ADM and DIEP flap were $9700.35 and $8644.23, which are lower than the actual costs. AB - CONCLUSIONS: DIEP flap breast reconstruction incurs lower costs compared to TE/I+ADM. These costs are lower at baseline and when additional costs from pooled complications are incorporated. Copyright © 2017 Wiley Periodicals, Inc. ES - 1096-9098 IL - 0022-4790 DO - https://dx.doi.org/10.1002/jso.24692 PT - Comparative Study PT - Journal Article ID - 10.1002/jso.24692 [doi] PP - ppublish PH - 2016/12/18 [received] PH - 2017/04/08 [accepted] LG - English EP - 20170607 DP - 2017 Sep EZ - 2017/06/08 06:00 DA - 2017/09/20 06:00 DT - 2017/06/08 06:00 YR - 2017 ED - 20170919 RD - 20180202 UP - 20180205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=28591940 <35. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28574950 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H AU - Piper M AU - Lentz R FA - Sbitany, Hani FA - Piper, Merisa FA - Lentz, Rachel IN - Sbitany, Hani. San Francisco, Calif. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, San Francisco. TI - Prepectoral Breast Reconstruction: A Safe Alternative to Submuscular Prosthetic Reconstruction following Nipple-Sparing Mastectomy. CM - Comment in: Plast Reconstr Surg. 2017 Sep;140(3):444-446; PMID: 28841598 SO - Plastic & Reconstructive Surgery. 140(3):432-443, 2017 Sep AS - Plast Reconstr Surg. 140(3):432-443, 2017 Sep NJ - Plastic and reconstructive surgery VO - 140 IP - 3 PG - 432-443 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous MH - Middle Aged MH - *Nipples MH - *Organ Sparing Treatments MH - Postoperative Complications MH - Prospective Studies MH - *Tissue Expansion/mt [Methods] AB - BACKGROUND: Nipple-sparing mastectomy with immediate prosthetic reconstruction is routinely performed because of excellent aesthetic results and safe oncologic outcomes. Typically, subpectoral expanders are placed, but in select patients, this can lead to significant postoperative pain and animation deformity, caused by pectoralis major muscle disinsertion and stretch. Prepectoral reconstruction is a technique that eliminates dissection of the pectoralis major by placing the prosthesis completely above the muscle with complete acellular dermal matrix coverage. AB - METHODS: A single surgeon's experience with immediate prosthetic reconstruction following nipple-sparing mastectomy from 2012 to 2016 was reviewed. Patient demographics, adjuvant treatment, length and characteristics of the expansion, and incidence of complications during the tissue expander stage were compared between the partial submuscular/partial acellular dermal matrix (dual-plane) cohort and the prepectoral cohort. AB - RESULTS: Fifty-one patients (84 breasts) underwent immediate prepectoral tissue expander placement, compared with 115 patients (186 breasts) undergoing immediate partial submuscular expander placement. The groups had similar comorbidities and postoperative radiation exposure. There was no significant difference in overall complication rate between the two groups (17.9 percent versus 18.8 percent; p = 0.49). AB - CONCLUSIONS: Prepectoral breast reconstruction provides a safe and effective alternative to partial submuscular reconstruction, that yields comparable aesthetic results with less operative morbidity. In the authors' experience, the incidence of acute and chronic postoperative pain and animation deformity is significantly lower following prepectoral breast reconstruction. This technique is now considered for all patients who are safe oncologic candidates and are undergoing nipple-sparing mastectomy and prosthetic reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003627 PT - Journal Article ID - 10.1097/PRS.0000000000003627 [doi] PP - ppublish LG - English DP - 2017 Sep EZ - 2017/06/03 06:00 DA - 2017/09/19 06:00 DT - 2017/06/03 06:00 YR - 2017 ED - 20170918 RD - 20171025 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28574950 <36. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22156884 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Adetayo OA AU - Salcedo SE AU - Bahjri K AU - Gupta SC FA - Adetayo, Oluwaseun A FA - Salcedo, Samuel E FA - Bahjri, Khaled FA - Gupta, Subhas C IN - Adetayo, Oluwaseun A. From the *Department of Plastic Surgery, Loma Linda University, Loma Linda, CA; and +Department of Epidemiology and Biostatistics, School of Public Health Loma Linda University, Loma Linda, CA. TI - A Meta-analysis of Outcomes Using Acellular Dermal Matrix in Breast and Abdominal Wall Reconstructions: Event Rates and Risk Factors Predictive of Complications. SO - Annals of Plastic Surgery. 77(2):e31-8, 2016 Aug AS - Ann Plast Surg. 77(2):e31-8, 2016 Aug NJ - Annals of plastic surgery VO - 77 IP - 2 PG - e31-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Abdominal Wall/su [Surgery] MH - *Abdominoplasty/mt [Methods] MH - *Acellular Dermis MH - Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Risk Factors AB - BACKGROUND: The use of acellular dermal matrix (ADM) has gained acceptance in breast and abdominal wall reconstructions. Despite its extensive use, there is currently a wide variation of reported outcomes in the literature. This study definitively elucidates the outcome rates associated with ADM use in breast and abdominal wall surgeries and identifies risk factors predisposing to the development of complications. AB - METHODS: A literature search was conducted using the Medline database (PubMed, US National Library of Medicine) and the Cochrane Library. A total of 464 articles were identified, of which 53 were eligible for meta-analysis. The endpoints of interest were the incidences of seroma, cellulitis, infection, wound dehiscence, implant failure, and hernia. The effects of various risk factors such as smoking, radiation, chemotherapy, and diabetes on the development of complications were also evaluated. AB - RESULTS: A majority of the studies were retrospective (68.6%) with a mean follow-up of 16.8 months (SD +/- 10.1 months) in the breast group and 14.2 months (SD +/- 7.8 months) in the abdominal wall reconstructive group. The overall risks and complications were as follows: cellulitis, 5.1%; implant failure, 5.9%; seroma formation, 8%; wound dehiscence, 8.1%; wound infection, 16.1%; hernia, 27.6%; and abdominal bulging, 28.1%. Complication rates were further stratified separately for the breast and abdominal cohorts, and the data were reported. This provides additional information on the associated abdominal wall morbidity in patients undergoing autologous breast reconstruction in which mesh reinforcement was considered as closure of the abdominal wall donor site. Radiation resulted in a significant increase in the rates of cellulitis (P = 0.021), and chemotherapy was associated with a higher incidence of seroma (P = 0.014). AB - CONCLUSION: This study evaluates the overall complication rates associated with ADM use by conducting a meta-analysis of published data. This will offer physicians a single comprehensive source of information during informed consent discussions as well as an awareness of the risk factors predictive of complications. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31822afae5 PT - Journal Article PT - Meta-Analysis ID - 10.1097/SAP.0b013e31822afae5 [doi] PP - ppublish LG - English DP - 2016 Aug EZ - 2011/12/14 06:00 DA - 2017/09/14 06:00 DT - 2011/12/14 06:00 YR - 2016 ED - 20170913 RD - 20170913 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=22156884 <37. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28528191 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tasoulis MK AU - Iqbal FM AU - Cawthorn S AU - MacNeill F AU - Vidya R FA - Tasoulis, M-K FA - Iqbal, F M FA - Cawthorn, S FA - MacNeill, F FA - Vidya, R IN - Tasoulis, M-K. Breast Surgery Unit, The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, SW3 6JJ, London, UK. Electronic address: mtasoulis@med.uoa.gr. IN - Iqbal, F M. Keele University, David Weatherall Building, ST5 5BG, Stoke-on-Trent, Staffordshire, UK. IN - Cawthorn, S. Breast Unit, Southmead Hospital Bristol, Southmead Road, BS10 5NB, Westbury-on-Trym, Bristol, UK. IN - MacNeill, F. Breast Surgery Unit, The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, SW3 6JJ, London, UK. IN - Vidya, R. Breast Department, Royal Wolverhampton Hospital, Wolverhampton Road, WV10 0QP, Wolverhampton, UK. TI - Subcutaneous implant breast reconstruction: Time to reconsider?. [Review] SO - European Journal of Surgical Oncology. 43(9):1636-1646, 2017 Sep AS - Eur J Surg Oncol. 43(9):1636-1646, 2017 Sep NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 43 IP - 9 PG - 1636-1646 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Humans MH - Mastectomy, Subcutaneous MH - Pain, Postoperative/et [Etiology] MH - Patient Selection MH - Surgical Mesh KW - Breast cancer; Breast reconstruction; Implant reconstruction; Pre-pectoral reconstruction; Subcutaneous implant reconstruction AB - Improvements in breast surgery techniques such as skin and nipple preserving mastectomy and innovative prosthetics (implants, acellular dermal matrices and meshes) is renewing interest in subcutaneous (pre-pectoral) implant reconstruction. The aim of this paper is to review the current literature in an attempt to provide a rationale that may support a return to subcutaneous implant placement, so minimising the pain and functional problems resulting from submuscular breast reconstruction. Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(17)30450-X DO - https://dx.doi.org/10.1016/j.ejso.2017.04.008 PT - Journal Article PT - Review ID - S0748-7983(17)30450-X [pii] ID - 10.1016/j.ejso.2017.04.008 [doi] PP - ppublish PH - 2016/12/29 [received] PH - 2017/03/25 [revised] PH - 2017/04/21 [accepted] LG - English EP - 20170504 DP - 2017 Sep EZ - 2017/05/22 06:00 DA - 2017/09/13 06:00 DT - 2017/05/22 06:00 YR - 2017 ED - 20170912 RD - 20170912 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28528191 <38. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28444764 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chang EI AU - Liu J AI - Chang, Edward I; ORCID: http://orcid.org/0000-0003-1067-9750 FA - Chang, Edward I FA - Liu, Jun IN - Chang, Edward I. Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX. IN - Liu, Jun. Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX. TI - Prospective unbiased experience with three acellular dermal matrices in breast reconstruction. SO - Journal of Surgical Oncology. 116(3):365-370, 2017 Sep AS - J Surg Oncol. 116(3):365-370, 2017 Sep NJ - Journal of surgical oncology VO - 116 IP - 3 PG - 365-370 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - k79, 0222643 IO - J Surg Oncol SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty MH - Mastectomy MH - Middle Aged MH - Prospective Studies MH - *Skin, Artificial MH - Treatment Outcome KW - acelluar dermal matrix; alloderm; breast reconstruction; dermacell; flex pliable AB - BACKGROUND: The use of acellular dermal matrix (ADM) has become the standard of care in breast reconstruction. However, the majority of current studies are biased or combine large databases introducing inherent flaws. Here, we present a prospective single surgeon experience comparing three ADM. AB - METHODS: All expander based breast reconstructions between 2014 and 2015 using ADM were included. AB - RESULTS: Eighteen patients (32 breasts) underwent reconstruction using Flex Pliable, 15 patients (22 breasts) used Alloderm, and 14 patients (20 breasts) had Dermacell. There were no significant differences in patient demographics or comorbidities. All expanders were placed into a subpectoral position, and there were no direct to implant cases. Average intraoperative fill was comparable, (Flex: 225cc, Alloderm: 180cc, Dermacell: 130cc). There were no differences in seroma, infection, or mastectomy skin flap necrosis rates. There were no cases of red breast, expander explanation or failed reconstruction in any cohort. Time to drain removal was significantly shorter in Flex and Dermacell patients compared to Alloderm (20 days vs 15 days vs 26 days, respectively; P=0.01). AB - CONCLUSIONS: While there are differences between available ADM, successful outcomes can be achieved with proper patient selection, sound surgical technique, and diligent post-operative management. Copyright © 2017 Wiley Periodicals, Inc. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1096-9098 IL - 0022-4790 DO - https://dx.doi.org/10.1002/jso.24656 PT - Comparative Study PT - Journal Article ID - 10.1002/jso.24656 [doi] PP - ppublish PH - 2016/12/18 [received] PH - 2017/03/30 [accepted] LG - English EP - 20170425 DP - 2017 Sep EZ - 2017/04/27 06:00 DA - 2017/09/09 06:00 DT - 2017/04/27 06:00 YR - 2017 ED - 20170908 RD - 20170908 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28444764 <39. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28654611 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lennox PA AU - Bovill ES AU - Macadam SA FA - Lennox, Peter A FA - Bovill, Esta S FA - Macadam, Sheina A IN - Lennox, Peter A. Vancouver, British Columbia, Canada From the Department of Surgery, Division of Plastic and Reconstructive Surgery, University of British Columbia. TI - Evidence-Based Medicine: Alloplastic Breast Reconstruction. SO - Plastic & Reconstructive Surgery. 140(1):94e-108e, 2017 Jul AS - Plast Reconstr Surg. 140(1):94e-108e, 2017 Jul NJ - Plastic and reconstructive surgery VO - 140 IP - 1 PG - 94e-108e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adipose Tissue/tr [Transplantation] MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - *Evidence-Based Medicine MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Time Factors MH - Tissue Scaffolds AB - LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the different advances that have resulted in improved outcomes in implant-based reconstruction. 2. Gain knowledge about specific techniques that have evolved rapidly in recent years and how to implement these. 3. Gain an understanding of controversies associated with alloplastic reconstruction. 4. Recognize undesirable outcomes in implant-based breast reconstruction and understand strategies for correction. AB - SUMMARY: There have been multiple advances in implant-based breast reconstruction. Many of these have resulted in improvements in patient outcomes and care. Understanding new techniques and technologies ensures competence in providing care for the alloplastic breast reconstruction patient. This article was prepared to accompany practice-based assessment with ongoing surgical education for the Maintenance of Certification for the American Board of Plastic Surgery. It is structured to outline the care of the patient with the postmastectomy breast deformity. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003472 PT - Journal Article PT - Video-Audio Media ID - 10.1097/PRS.0000000000003472 [doi] ID - 00006534-201707000-00039 [pii] PP - ppublish LG - English DP - 2017 Jul EZ - 2017/06/28 06:00 DA - 2017/09/08 06:00 DT - 2017/06/28 06:00 YR - 2017 ED - 20170907 RD - 20170907 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28654611 <40. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28654596 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mendenhall SD AU - Schmucker RW AU - Daugherty THF AU - Kottwitz KM AU - Reichensperger JD AU - Koirala J AU - Cederna PS AU - Neumeister MW FA - Mendenhall, Shaun D FA - Schmucker, Ryan W FA - Daugherty, Timothy H F FA - Kottwitz, Katherine M FA - Reichensperger, Joel D FA - Koirala, Janak FA - Cederna, Paul S FA - Neumeister, Michael W IN - Mendenhall, Shaun D. Springfield, Ill.; and Ann Arbor, Mich. From the Institute for Plastic Surgery, the Laboratory for Regenerative Medicine and Applied Sciences, the Division of Infectious Diseases, Southern Illinois University School of Medicine; and the Section of Plastic Surgery, University of Michigan School of Medicine. TI - A Microbiological and Ultrastructural Comparison of Aseptic versus Sterile Acellular Dermal Matrix as a Reconstructive Material and a Scaffold for Stem Cell Ingrowth. SO - Plastic & Reconstructive Surgery. 140(1):97-108, 2017 Jul AS - Plast Reconstr Surg. 140(1):97-108, 2017 Jul NJ - Plastic and reconstructive surgery VO - 140 IP - 1 PG - 97-108 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/mi [Microbiology] MH - *Asepsis MH - Cells, Cultured MH - *Collagen/ul [Ultrastructure] MH - DNA, Bacterial/an [Analysis] MH - DNA, Fungal/an [Analysis] MH - Humans MH - Microscopy, Electron, Scanning MH - *Stem Cells MH - *Sterilization MH - *Tissue Scaffolds/mi [Microbiology] AB - BACKGROUND: Recent data suggest an increased risk for infection when acellular dermal matrix is used in breast reconstruction. This may be because some acellular dermal matrices are actually not terminally sterilized but are instead "aseptically processed." This study evaluates aseptic and sterile matrices for evidence of bacterial contamination and whether or not terminal sterilization affects matrix collagen architecture and stem cell ingrowth. AB - METHODS: Five separate samples of 14 different matrices were analyzed by fluorescent in situ hybridization using a bacterial DNA probe to detect bacterial DNA on the matrices. Separate samples were incubated for bacteria, acid-fast bacilli, and fungi for 2 to 6 weeks to detect living organisms. The impact of terminal sterilization on the collagen network and stem cell ingrowth on the matrices was then assessed. AB - RESULTS: Traces of bacterial DNA were encountered on all matrices, with more bacteria in the aseptic group compared with the sterile group (3.4 versus 1.6; p = 0.003). The number of positive cultures was the same between groups (3.8 percent). Electron microscopy demonstrated decreased collagen organization in the sterile group. Stem cell seeding on the matrices displayed a wide variation of cellular ingrowth between matrices, with no difference between aseptic and sterile groups (p = 0.2). AB - CONCLUSIONS: Although there was more evidence of prior bacterial contamination on aseptically processed matrices compared with sterile matrices; clinical cultures did not differ between groups. Terminal sterilization does not appear to affect stem cell ingrowth but may come at the cost of damaging the collagen network. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V. RN - 0 (DNA, Bacterial) RN - 0 (DNA, Fungal) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003448 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0000000000003448 [doi] ID - 00006534-201707000-00020 [pii] PP - ppublish LG - English DP - 2017 Jul EZ - 2017/06/28 06:00 DA - 2017/09/08 06:00 DT - 2017/06/28 06:00 YR - 2017 ED - 20170907 RD - 20170907 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28654596 <41. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28624524 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ball JF AU - Sheena Y AU - Tarek Saleh DM AU - Forouhi P AU - Benyon SL AU - Irwin MS AU - Malata CM FA - Ball, Jessica F FA - Sheena, Yezen FA - Tarek Saleh, Dina M FA - Forouhi, Parto FA - Benyon, Sarah L FA - Irwin, Michael S FA - Malata, Charles M IN - Ball, Jessica F. Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK. IN - Sheena, Yezen. Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK. IN - Tarek Saleh, Dina M. Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK. IN - Forouhi, Parto. Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK. IN - Benyon, Sarah L. Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK. IN - Irwin, Michael S. Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK. IN - Malata, Charles M. Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK; Postgraduate Medical Institute, Faculty of Medical Science, Anglia Ruskin University, Cambridge and Chelmsford, UK. Electronic address: charles.malata@addenbrookes.nhs.uk. TI - A direct comparison of porcine (StratticeTM) and bovine (SurgimendTM) acellular dermal matrices in implant-based immediate breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 70(8):1076-1082, 2017 Aug AS - J Plast Reconstr Aesthet Surg. 70(8):1076-1082, 2017 Aug NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 70 IP - 8 PG - 1076-1082 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - Aged MH - Animals MH - *Breast/pa [Pathology] MH - Breast Implants MH - *Breast Neoplasms/th [Therapy] MH - Cattle MH - Collagen/ae [Adverse Effects] MH - *Collagen/tu [Therapeutic Use] MH - Erythema/et [Etiology] MH - Female MH - Hematoma/et [Etiology] MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty MH - Mastectomy MH - Middle Aged MH - Necrosis MH - Organ Size MH - Reoperation MH - Retrospective Studies MH - Seroma/et [Etiology] MH - *Skin/pa [Pathology] MH - Surgical Wound Dehiscence/et [Etiology] MH - Surgical Wound Infection/et [Etiology] MH - Swine MH - Time Factors MH - Young Adult KW - Acellular dermal matrix; Breast reconstruction; Implant; Strattice; Surgimend AB - INTRODUCTION: Acellular dermal matrix (ADM) assisted implant-based breast reconstruction (IBBR) has grown in popularity over traditional submuscular techniques. Numerous human, bovine or porcine derived ADMs are available with the type used varying considerably worldwide. Yet, comparative evidence for the efficacy of different ADMs particularly xenogenic is limited. This study directly compares early outcomes of porcine (StratticeTM) and bovine (SurgimendTM) ADMs in IBBR. AB - METHOD: Retrospective study of sequential experience of immediate IBBR using Strattice or Surgimend ADM. Data was collected for patients undergoing ADM assisted IBBR after prophylactic or therapeutic mastectomy in Cambridge (October 2011-March 2016). Patient demographics, adjuvant and neoadjuvant therapies, operative details, postoperative management and outcomes were analysed. AB - KEY RESULTS: Total of 81 patients underwent IBBR with ADM; 38 bilateral and 43 unilateral (n = 119 breasts). Strattice was used in 30 breasts (25%) and Surgimend in 89 (75%). Analysis of patient specific variables showed statistical significance only for higher mastectomy weight in the Strattice group (367.1 +/- 159.3 g versus 296.3 +/- 133.4 g; P = 0.0379). Strattice was associated with higher rates of skin erythema post-operatively (16.7% versus 4.5%; P = 0.044). Analysed per woman or per breast, there was no statistically significant difference in rates of haematoma, infection, wound dehiscence, skin necrosis or seroma, although there was a trend towards more complications with Strattice. AB - CONCLUSION: This study found significantly higher rates of skin erythema and a trend towards higher complication rates with Strattice in IBBR. Randomised controlled trials comparing different ADM outcomes are needed to inform best practice. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved. RN - 0 (Surgimend) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30193-6 DO - https://dx.doi.org/10.1016/j.bjps.2017.05.015 PT - Comparative Study PT - Journal Article ID - S1748-6815(17)30193-6 [pii] ID - 10.1016/j.bjps.2017.05.015 [doi] PP - ppublish PH - 2017/01/30 [received] PH - 2017/05/06 [revised] PH - 2017/05/12 [accepted] LG - English EP - 20170519 DP - 2017 Aug EZ - 2017/06/19 06:00 DA - 2017/09/07 06:00 DT - 2017/06/19 06:00 YR - 2017 ED - 20170905 RD - 20170906 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28624524 <42. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27187248 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - DeGeorge BR Jr AU - Olenczak JB AU - Cottler PS AU - Drake DB AU - Lin KY AU - Morgan RF AU - Campbell CA FA - DeGeorge, Brent R Jr FA - Olenczak, J Bryce FA - Cottler, Patrick S FA - Drake, David B FA - Lin, Kant Y FA - Morgan, Raymond F FA - Campbell, Christopher A IN - DeGeorge, Brent R Jr. From the Department of Plastic Surgery, University of Virginia Health System, Charlottesville, VA. TI - Evaluation of Sidestream Darkfield Microscopy for Real-Time Imaging Acellular Dermal Matrix Revascularization. SO - Annals of Plastic Surgery. 76 Suppl 4:S255-9, 2016 Jun AS - Ann Plast Surg. 76 Suppl 4:S255-9, 2016 Jun NJ - Annals of plastic surgery VO - 76 Suppl 4 PG - S255-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Computer Systems MH - Feasibility Studies MH - Female MH - *Guided Tissue Regeneration/mt [Methods] MH - Humans MH - *Intraoperative Care/mt [Methods] MH - *Microscopy/mt [Methods] MH - Microvessels/ah [Anatomy & Histology] MH - Microvessels/dg [Diagnostic Imaging] MH - Microvessels/ph [Physiology] MH - *Neovascularization, Physiologic MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - *Tissue Scaffolds AB - BACKGROUND: Acellular dermal matrices (ADMs) serve as a regenerative framework for host cell integration and collagen deposition to augment the soft tissue envelope in ADM-assisted breast reconstruction-a process dependent on vascular ingrowth. To date noninvasive intra-operative imaging techniques have been inadequate to evaluate the revascularization of ADM. AB - METHODS: We investigated the safety, feasibility, and efficacy of sidestream darkfield (SDF) microscopy to assess the status of ADM microvascular architecture in 8 patients at the time of tissue expander to permanent implant exchange during 2-stage ADM-assisted breast reconstruction. The SDF microscopy is a handheld device, which can be used intraoperatively for the real-time assessment of ADM blood flow, vessel density, vessel size, and branching pattern. The SDF microscopy was used to assess the microvascular architecture in the center and border zone of the ADM and to compare the native, non-ADM-associated capsule in each patient as a within-subject control. AB - RESULTS: No incidences of periprosthetic infection, explantation, or adverse events were reported after SDF image acquisition. Native capsules demonstrate a complex, layered architecture with an average vessel area density of 14.9 mm/mm and total vessel length density of 12.3 mm/mm. In contrast to native periprosthetic capsules, ADM-associated capsules are not uniformly vascularized structures and demonstrate 2 zones of microvascular architecture. The ADM and native capsule border zone demonstrates palisading peripheral vascular arcades with continuous antegrade flow. The central zone of the ADM demonstrates punctate perforating vascular plexi with intermittent, sluggish flow, and intervening 2- to 3-cm watershed zones. AB - CONCLUSIONS: Sidestream darkfield microscopy allows for real-time intraoperative assessment of ADM revascularization and serves as a potential methodology to compare revascularization parameters among commercially available ADMs. Thr SDF microscopy demonstrates that the periprosthetic capsule in ADM-assisted implant-based breast reconstruction is not a uniformly vascularized structure. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000832 PT - Clinical Trial PT - Journal Article ID - 10.1097/SAP.0000000000000832 [doi] ID - 00000637-201606004-00001 [pii] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/05/18 06:00 DA - 2017/09/02 06:00 DT - 2016/05/18 06:00 YR - 2016 ED - 20170901 RD - 20170901 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27187248 <43. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26954737 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kalus R AU - Dixon Swartz J AU - Metzger SC FA - Kalus, Ram FA - Dixon Swartz, Jennifer FA - Metzger, Sarah Cristina IN - Kalus, Ram. From the *Plastic Surgery of the Carolinas, Mount Pleasant, SC; +Division of Plastic Surgery, Medical University of South Carolina, Charleston, SC; and ++Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany. TI - Optimizing Safety, Predictability, and Aesthetics in Direct to Implant Immediate Breast Reconstruction: Evolution of Surgical Technique. SO - Annals of Plastic Surgery. 76 Suppl 4:S320-7, 2016 Jun AS - Ann Plast Surg. 76 Suppl 4:S320-7, 2016 Jun NJ - Annals of plastic surgery VO - 76 Suppl 4 PG - S320-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Aged, 80 and over MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Esthetics MH - Female MH - Humans MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Patient Safety MH - Patient Selection MH - Postoperative Complications/ep [Epidemiology] MH - Reoperation/sn [Statistics & Numerical Data] MH - Retrospective Studies AB - BACKGROUND: Although immediate breast reconstruction with the insertion of a permanent prosthesis rather than a tissue expander (direct to implant [DTI]) has become gradually more preferred and requested by patients, the technique has yet to be fully embraced by most plastic surgeons, presumably due to concerns of patient safety and perceived higher complication and revision rates, despite not being supported by the literature. AB - OBJECTIVES: The authors review the senior author's protocol for patient selection and surgical technique in DTI reconstructions. A simple device is introduced which adds predictability and control in determining the inset suture line for the acellular dermal matrix and thus the position of the inframammary fold and lateral mammary fold, resulting in improved aesthetic outcomes, reduced complications, and reduced reoperation rates. AB - METHODS: A retrospective review of our one surgeon experience with 134 DTI breast reconstructions in 77 patients between 2006 and 2015 is presented. The series is further subdivided into 74 reconstructions in 43 patients in whom their reconstruction was performed before the use of a patented 2-dimensional (2-D) template, and 60 reconstructions in 34 patients in whom the template was used. AB - RESULTS: The overall complication rate requiring reoperation in the first 54 reconstructions was 50% versus 15% in the last 84. Failure of the reconstruction, defined by explantation, occurred in 11 of 74 reconstructions (14.9%) before the use of 2-D templates, and in 5 of 60 reconstructions (8.3%) in which templates were used, representing a 44% reduction. The revision rate specifically for implant malposition dropped from 18.6% before the use of templates to 2.9% after the incorporation of templates. Fifty-three reconstructions in 33 patients (40%) had no complications and no reoperations, correctly described as "one and done." AB - CONCLUSIONS: Direct to implant reconstruction can be technically more demanding and exacting than 2-stage expander/implant reconstructions. A review of this single surgeon series confirms that despite a learning curve with a higher complication rate early in the series, in the setting of proper patient selection DTI immediate reconstruction is both safe and reliable, and can potentially have clinical, psychological, and aesthetic advantages for patients when compared with a 2-stage expander/implant reconstruction, with 40% of patients having 1 operation only. The use of a patented 2-D template has reduced complications and the rate of reoperation. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000771 PT - Journal Article ID - 10.1097/SAP.0000000000000771 [doi] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/03/10 06:00 DA - 2017/09/02 06:00 DT - 2016/03/09 06:00 YR - 2016 ED - 20170901 RD - 20170901 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26954737 <44. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26954734 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Freeman MD AU - Vemula R AU - Rao R AU - Matatov TS AU - Strong AL AU - Tandon R AU - Chaffin AE AU - Jansen DA FA - Freeman, Matthew D FA - Vemula, Rahul FA - Rao, Rahul FA - Matatov, Tim S FA - Strong, Amy L FA - Tandon, Ravi FA - Chaffin, Abigail E FA - Jansen, David A IN - Freeman, Matthew D. From the *Tulane University School of Medicine, +Division of Plastic and Reconstructive Surgery, Tulane University School of Medicine, New Orleans; ++Private Practice, Metairie, LA. TI - Refinements in the Techniques of 2-Stage Breast Reconstruction. SO - Annals of Plastic Surgery. 76 Suppl 4:S304-11, 2016 Jun AS - Ann Plast Surg. 76 Suppl 4:S304-11, 2016 Jun NJ - Annals of plastic surgery VO - 76 Suppl 4 PG - S304-11 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Retrospective Studies MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - BACKGROUND: Two-stage breast reconstruction with tissue expanders is one of the most common plastic surgery procedures. Acellular dermal matrix (ADM) has become popular for its ability to improve expansion parameters and aesthetics, albeit with a higher complication profile. We present data that support redefining 2-stage reconstruction to include tissue expanders regardless of final reconstructive modality to act as a bridge. Furthermore, we show that cooperation with the ablative surgeon and technical refinements support ADM omission from the first stage of reconstruction. AB - METHODS: We retrospectively reviewed charts from the senior author's (D.A.J.) private practice over a 10-year follow-up period. Inclusion criteria included all women over 18 years who underwent mastectomy and had a tissue expander placed immediately or in a delayed fashion and successfully completed tissue expansion and are finished with the second stage of reconstruction or awaiting second stage of reconstruction. Demographic data, tissue expander filling data, final reconstruction, aesthetic outcome, and complications were tabulated. AB - RESULTS: A total of 118 women (165 breasts) met inclusion criteria. There were no statistically significant differences in initial fill volume (P = 0.094), number of visits until final expansion (P = 0.677), or final fill volume (P = 0.985) between the ADM and non-ADM cohorts. In addition, non-ADM patients had superior aesthetic scores with respect to defects other than scarring (P = 0.015), projection (P = 0.013), and inframammary fold quality (P = 0.009). Fifteen percent of women decided to change desired final reconstruction modality during the tissue expansion phase. AB - CONCLUSIONS: This reconstructive algorithm emphasizes surgical cooperation between the ablative and reconstructive surgeon, improved technique, and patient education. This focus translates into maintained tissue expansion, aesthetically pleasing results, and allows for the omission of ADM from reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000763 PT - Journal Article ID - 10.1097/SAP.0000000000000763 [doi] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/03/10 06:00 DA - 2017/09/02 06:00 DT - 2016/03/09 06:00 YR - 2016 ED - 20170901 RD - 20170901 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26954734 <45. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26918525 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dayicioglu D AU - Trotta R AU - Agoris C AU - Kumar A FA - Dayicioglu, Deniz FA - Trotta, Rose FA - Agoris, Corin FA - Kumar, Ambuj IN - Dayicioglu, Deniz. From the *Division of Plastic Surgery, Department of Surgery, University of South Florida, Morsani College of Medicine; +University of South Florida, Morsani College of Medicine; and ++Clinical and Translational Science Institute, University of South Florida, Morsani College of Medicine, Tampa, FL. TI - Duoderm-Bra for Nipple-Sparing Mastectomy. SO - Annals of Plastic Surgery. 76 Suppl 4:S280-5, 2016 Jun AS - Ann Plast Surg. 76 Suppl 4:S280-5, 2016 Jun NJ - Annals of plastic surgery VO - 76 Suppl 4 PG - S280-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Bandages, Hydrocolloid MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - *Nipples/su [Surgery] MH - Outcome Assessment (Health Care) MH - Retrospective Studies MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - BACKGROUND: Nipple-sparing mastectomy (NSM) with tissue expander reconstruction is a widely used technique that can produce aesthetically pleasing reconstruction results after mastectomy. Nipple position and healthy mastectomy flaps with good vascularity are important determinants of an adequate aesthetic final result. An initial high fill volume of the expander can produce a more natural breast mound appearance postoperatively. However, this can often lead to ischemia with loss of the nipple-areolar complex (NAC). Conversely, low intraoperative fill rates are conducive to enhanced tissue circulation and viability. But this may lead to poor skin envelope draping and nipple placement lower than desired. We have developed a new technique called "Duoderm-bra" that brings together both mastectomy skin tissue health and aesthetic success with optimal nipple positioning. We hypothesized that with Duoderm-bra, the NAC can be stabilized in the desired high position and ptosis can be reduced. We also hypothesized that by eliminating the need for acellular dermal matrix and intraoperative fill, "Duoderm-bra" would decrease the rate of complications. The objective of this study was to evaluate the effects of using novel "Duoderm-bra" technique in NSM. AB - METHODS: After an institutional review board approval, a retrospective chart review of 35 consecutive patients was done with 65 breasts undergoing NSM and tissue expander reconstruction by the same plastic surgeon. Patients in whom "Duoderm-bra" was used were compared with patients without the "Duoderm-bra." Patients with acellular dermal matrix were excluded. Age, ptosis grade, preoperative nipple to IMF ratio (R/L), tumor characteristics, mastectomy specimen weight (R/L), time from mastectomy to first fill, time from mastectomy to final fill, final fill volume (R/L), NAC and skin necrosis, and other complications requiring surgery were recorded. Postoperative photographs for NAC positioning (side view most projected point versus at a lower point) were assessed using a scoring system. Two groups were then compared. AB - RESULTS: Complications were higher in the non-Duoderm group compared with Duoderm-bra (odds ratio, 4.5; 95% confidence interval [CI], 1.35-15.04; P = 0.021). Optimum nipple positioning was significantly higher with Duoderm-bra compared with no Duoderm-bra (odds ratio, 50.0; 95% CI, 10.9-230.1; P < 0.0001). There was no difference in timing from mastectomy to completion of expansion in the Duoderm group compared with no Duoderm-bra group (mean difference, -2.35; 95% CI, -10.37 to 5.68). AB - CONCLUSIONS: Use of "Duoderm-bra" without intraoperative tissue expansion in NSM is a new technique. This technique improves nipple position with less ptosis and greater elevation, decreases flap and NAC necrosis complications, and does not increase total reconstructive period in NSM patients. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000753 PT - Journal Article ID - 10.1097/SAP.0000000000000753 [doi] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/02/27 06:00 DA - 2017/09/02 06:00 DT - 2016/02/27 06:00 YR - 2016 ED - 20170901 RD - 20170901 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26918525 <46. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26914348 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hanna KR AU - Tilt A AU - Holland M AU - Colen D AU - Bowen B AU - Stovall M AU - Lee A AU - Wang J AU - Drake D AU - Lin K AU - Uroskie T AU - Campbell CA FA - Hanna, Kasandra R FA - Tilt, Alexandra FA - Holland, Michael FA - Colen, David FA - Bowen, Byers FA - Stovall, Madeline FA - Lee, Andy FA - Wang, Jessica FA - Drake, David FA - Lin, Kant FA - Uroskie, Theodore FA - Campbell, Chris A IN - Hanna, Kasandra R. From the *Department of Plastic and Reconstructive Surgery, University of Virginia, Charlottesville; and +Department of Plastic and Reconstructive Surgery, Eastern Virginia Medical School, Virginia Beach, VA. TI - Reducing Infectious Complications in Implant Based Breast Reconstruction: Impact of Early Expansion and Prolonged Drain Use. SO - Annals of Plastic Surgery. 76 Suppl 4:S312-5, 2016 Jun AS - Ann Plast Surg. 76 Suppl 4:S312-5, 2016 Jun NJ - Annals of plastic surgery VO - 76 Suppl 4 PG - S312-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Drainage/ae [Adverse Effects] MH - *Drainage/mt [Methods] MH - Female MH - Follow-Up Studies MH - Humans MH - Logistic Models MH - Middle Aged MH - Necrosis/ep [Epidemiology] MH - Necrosis/et [Etiology] MH - Necrosis/pc [Prevention & Control] MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Risk Factors MH - Seroma/ep [Epidemiology] MH - Seroma/et [Etiology] MH - Seroma/pc [Prevention & Control] MH - Skin/pa [Pathology] MH - Surgical Wound Dehiscence/ep [Epidemiology] MH - Surgical Wound Dehiscence/et [Etiology] MH - Surgical Wound Dehiscence/pc [Prevention & Control] MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/et [Etiology] MH - Surgical Wound Infection/pc [Prevention & Control] MH - Time Factors MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - Treatment Outcome AB - INTRODUCTION: The most common modality of breast reconstruction continues to be implant based, with infection being the most significant complication. Risk factors including radiation, obesity, and smoking have been associated with infection and other surgical complications. We hypothesized that prolonged drain use may likewise be associated with postoperative complications, particularly infection, and that early postoperative expansion may allow for earlier drain removal and improved outcomes. AB - METHODS: A retrospective chart review was performed to identify all immediate, tissue expander-based breast reconstruction patients using acellular dermal matrix. Time to first expansion, postoperative day (POD) of drain removal, and complication data including infection, seroma, wound separation, and skin necrosis were collected. Early expansion was defined as occurring before POD14, and prolonged drain duration as removal after POD21. Logistic regression was used to identify risk factors for complications. Fisher's exact test was used to compare complications between early and late drain removal and early and late expansion. Spearman correlation was used to define the relationship of early expansion and drain duration. AB - RESULTS: Three hundred twenty-three breast reconstructions met inclusion criteria. Our overall infection rate was 11.8%, seroma was 2.2%, skin necrosis 1.9%, and wound separation 4.3%. Logistic regression revealed prolonged drain use as an independent risk factor for infection (odds ratio, 3.3; P = 0.002). Earlier expansion was correlated with earlier post operative drain removal (r = 0.3, P = 0.001) with fewer early expansion patients (7.4%) requiring prolonged drain use than those undergoing late expansion (24.7%). Smoking was also associated with skin flap necrosis (odds ratio, 8.0; P = 0.002). AB - CONCLUSIONS: Prolonged drain use was associated with postoperative infection and may represent an independent source of infection or may be an indicator of delayed healing. Early tissue expansion was associated with earlier drain removal and so may help avoid infectious complications and improve outcomes. Early expansion was not associated with an increase in complications. Results from this study have informed our current drain management practice. Whether this has led to a reduction in our infection rate is a future topic of study. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000760 PT - Journal Article ID - 10.1097/SAP.0000000000000760 [doi] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/02/26 06:00 DA - 2017/09/02 06:00 DT - 2016/02/26 06:00 YR - 2016 ED - 20170901 RD - 20170901 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26914348 <47. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25057918 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H AU - Wang F AU - Peled AW AU - Alvarado M AU - Ewing CA AU - Esserman LJ AU - Foster RD FA - Sbitany, Hani FA - Wang, Frederick FA - Peled, Anne W FA - Alvarado, Michael FA - Ewing, Cheryl A FA - Esserman, Laura J FA - Foster, Robert D IN - Sbitany, Hani. From the Divisions of *Plastic and Reconstructive Surgery, and +Surgical Oncology, University of California, San Francisco, San Francisco, CA. TI - Tissue Expander Reconstruction After Total Skin-Sparing Mastectomy: Defining the Effects of Coverage Technique on Nipple/Areola Preservation. SO - Annals of Plastic Surgery. 77(1):17-24, 2016 Jan AS - Ann Plast Surg. 77(1):17-24, 2016 Jan NJ - Annals of plastic surgery VO - 77 IP - 1 PG - 17-24 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - Linear Models MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous MH - Middle Aged MH - *Nipples/su [Surgery] MH - Prospective Studies MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Total skin-sparing mastectomy (TSSM) has become increasingly frequent in recent years, as inclusion criteria continue to expand. Options for tissue expander coverage in these patients include complete submuscular tissue expander coverage and acellular dermal matrix (ADM)-assisted coverage. This study compares both techniques with regard to relevant outcomes, during a recent 1-year period at our institution. AB - METHODS: All women undergoing TSSM and immediate expander placement between January 2012 and January 2013 were prospectively tracked. Patient demographics, expander coverage type, adjuvant treatment, length and characteristics of expansion, and incidence of complications were analyzed. AB - RESULTS: In 1 year, 127 patients underwent TSSM on 202 breasts. Overall, 113 expanders underwent submuscular coverage, and 89 underwent ADM-assisted coverage. Mean intraoperative fill volume was 52 mL in the submuscular cohort and 205 mL in the ADM cohort (P = 0.0001). Mean tissue expander size was 404 mL in the submuscular cohort and 454 mL in the ADM cohort (P = 0.0002). chi analysis demonstrated no differences between the cohorts in incidence of complications, including partial/complete nipple necrosis. AB - CONCLUSIONS: The use of ADM for expander coverage after TSSM allowed for greater initial expander fill. With large and ptotic breasts, this allows for reduced incidence of skin folds in the preserved breast skin pocket, and greater control over final nipple position, as the amount of loose, mobile skin is reduced by the greater initial fill. The safety profile of ADM use after TSSM is equivalent to that of submuscular coverage, with no differences in partial or complete nipple necrosis. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000292 PT - Clinical Trial PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0000000000000292 [doi] PP - ppublish LG - English DP - 2016 Jan EZ - 2014/07/25 06:00 DA - 2017/09/02 06:00 DT - 2014/07/25 06:00 YR - 2016 ED - 20170901 RD - 20170901 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25057918 <48. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28233127 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Graf RM AU - Ono MC FA - Graf, Ruth Maria FA - Ono, Maria Cecilia Closs IN - Graf, Ruth Maria. Department of Plastic Surgery, Federal University of Parana, Curitiba, Brazil. ruthgraf@uol.com.br. IN - Graf, Ruth Maria. Pieta Centro Medico, Rua Solimoes, 1175, Merces, Curitiba, Parana, 80.810-070, Brazil. ruthgraf@uol.com.br. IN - Ono, Maria Cecilia Closs. Department of Plastic Surgery, Federal University of Parana, Curitiba, Brazil. TI - Re: "Impact of Acellular Dermal Matrix (ADM) Use Under Mastectomy Flap Necrosis on Perioperative Outcomes of Prosthetic Breast Reconstruction". CM - Comment on: Ann Plast Surg. 2012 Apr;68(4):346-56; PMID: 22421476 CM - Comment on: Aesthetic Plast Surg. 2017 Apr;41(2):275-281; PMID: 28204936 SO - Aesthetic Plastic Surgery. 41(2):282-283, 2017 04 AS - Aesthetic Plast Surg. 41(2):282-283, 2017 04 NJ - Aesthetic plastic surgery VO - 41 IP - 2 PG - 282-283 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Neoplasms/su [Surgery] MH - Humans MH - Mammaplasty MH - *Mastectomy ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0815-1 PT - Journal Article PT - Comment ID - 10.1007/s00266-017-0815-1 [doi] ID - 10.1007/s00266-017-0815-1 [pii] PP - ppublish PH - 2017/02/02 [received] PH - 2017/02/03 [accepted] LG - English EP - 20170223 DP - 2017 04 EZ - 2017/02/25 06:00 DA - 2017/08/29 06:00 DT - 2017/02/25 06:00 YR - 2017 ED - 20170828 RD - 20170828 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28233127 <49. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27523925 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - El Hage Chehade H AU - Headon H AU - Wazir U AU - Carmaichael AR AU - Choy C AU - Kasem A AU - Mokbel K FA - El Hage Chehade, Hiba FA - Headon, Hannah FA - Wazir, Umar FA - Carmaichael, Amtul R FA - Choy, Christina FA - Kasem, Abdul FA - Mokbel, Kefah IN - El Hage Chehade, Hiba. The London Breast Institute, Princess Grace Hospital, London, UK. IN - Headon, Hannah. The London Breast Institute, Princess Grace Hospital, London, UK. IN - Wazir, Umar. The London Breast Institute, Princess Grace Hospital, London, UK. IN - Carmaichael, Amtul R. The London Breast Institute, Princess Grace Hospital, London, UK. IN - Choy, Christina. The London Breast Institute, Princess Grace Hospital, London, UK. IN - Kasem, Abdul. The London Breast Institute, Princess Grace Hospital, London, UK. IN - Mokbel, Kefah. The London Breast Institute, Princess Grace Hospital, London, UK. Electronic address: kefahmokbel@hotmail.com. TI - Nipple-sparing mastectomy using a hemi-periareolar incision with or without minimal medial-lateral extensions; clinical outcome and patient satisfaction: A single centre prospective observational study. SO - American Journal of Surgery. 213(6):1116-1124, 2017 Jun AS - Am J Surg. 213(6):1116-1124, 2017 Jun NJ - American journal of surgery VO - 213 IP - 6 PG - 1116-1124 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 3z4, 0370473 IO - Am. J. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - *Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Humans MH - Mammaplasty MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Nipples MH - *Patient Satisfaction MH - Prospective Studies MH - Treatment Outcome KW - Breast cancer; Immediate breast reconstruction; Nipple-sparing mastectomy; Periareolar incision AB - BACKGROUND: Nipple-sparing mastectomy (NSM) is becoming a viable oncoplastic option. There is debate regarding the best approach that balances oncological safety with aesthetics. In this study, we describe an approach involving a hemi-periareolar incision and evaluate its safety and outcomes. AB - METHODS: Patients treated at single center between 2012 and 2015 were observed prospectively. After a histologically negative subareolar biopsy, immediate reconstruction with implant and acellular dermal matrix was performed after NSM. Primary end points were wound complications and explantation. Secondary end points included local recurrence, quality of life, patient satisfaction, and esthetic outcome. AB - RESULTS: Sixty-three patients were included with 92 procedures. Twenty-seven percent received chemotherapy and 12.7% received radiotherapy. Mean follow-up was 27.6 months. There were only 2 wound complications, and no recurrences. Mean outcome scores were promising (Breast Q = 88%, subjective esthetic = 9.2, objective esthetic = 9.3, hardening = 2.6). AB - CONCLUSIONS: NSM via a hemi-periareolar incision is oncologically safe with a low-complication rate and high patients' satisfaction. Copyright © 2016 Elsevier Inc. All rights reserved. ES - 1879-1883 IL - 0002-9610 DI - S0002-9610(16)30359-2 DO - https://dx.doi.org/10.1016/j.amjsurg.2016.04.016 PT - Journal Article PT - Observational Study ID - S0002-9610(16)30359-2 [pii] ID - 10.1016/j.amjsurg.2016.04.016 [doi] PP - ppublish PH - 2016/03/24 [received] PH - 2016/04/11 [revised] PH - 2016/04/19 [accepted] LG - English EP - 20160721 DP - 2017 Jun EZ - 2016/08/16 06:00 DA - 2017/08/22 06:00 DT - 2016/08/16 06:00 YR - 2017 ED - 20170821 RD - 20170821 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27523925 <50. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28215734 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Pukancsik D AU - Kelemen P AU - Gulyas G AU - Ujhelyi M AU - Kovacs E AU - Eles K AU - Meszaros N AU - Kenessey I AU - Palhazi P AU - Kovacs T AU - Kasler M AU - Matrai Z FA - Pukancsik, D FA - Kelemen, P FA - Gulyas, G FA - Ujhelyi, M FA - Kovacs, E FA - Eles, K FA - Meszaros, N FA - Kenessey, I FA - Palhazi, P FA - Kovacs, T FA - Kasler, M FA - Matrai, Z IN - Pukancsik, D. National Institute of Oncology, Department of Breast and Sarcoma Surgery, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. Electronic address: d.pukancsik@gmail.com. IN - Kelemen, P. National Institute of Oncology, Department of Breast and Sarcoma Surgery, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Gulyas, G. National Institute of Oncology, Department of Breast and Sarcoma Surgery, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Ujhelyi, M. National Institute of Oncology, Department of Breast and Sarcoma Surgery, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Kovacs, E. National Institute of Oncology, Department of Radiological Diagnostics, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Eles, K. National Institute of Oncology, Department of Surgical and Molecular Pathology, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Meszaros, N. National Institute of Oncology, Department of Radiotherapy, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Kenessey, I. National Institute of Oncology, National Cancer Registry, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary; Semmelweis University, 2nd Department of Pathology, Ulloi Str. 93, 1091 Budapest, Hungary. IN - Palhazi, P. Semmelweis University, Department of Anatomy, Histology and Embryology, Tuzolto Str. 58, 1094 Budapest, Hungary. IN - Kovacs, T. Guy's and St Thomas's Hospitals NHS Foundation Trust, Department of Breast Surgery, Great Maze Pond, London SE1 9RT, United Kingdom. IN - Kasler, M. National Institute of Oncology, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. IN - Matrai, Z. National Institute of Oncology, Department of Breast and Sarcoma Surgery, Rath Gyorgy Str. 7-9, 1122 Budapest, Hungary. TI - Clinical experiences with the use of ULTRAPRO mesh in single-stage direct-to-implant immediate postmastectomy breast reconstruction in 102 patients: A retrospective cohort study. SO - European Journal of Surgical Oncology. 43(7):1244-1251, 2017 Jul AS - Eur J Surg Oncol. 43(7):1244-1251, 2017 Jul NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 43 IP - 7 PG - 1244-1251 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - Absorbable Implants MH - Adult MH - Breast Neoplasms/ge [Genetics] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Genes, BRCA1 MH - Genes, BRCA2 MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/is [Instrumentation] MH - Mastectomy, Subcutaneous MH - Middle Aged MH - Neoplasm Staging MH - *Postoperative Complications/et [Etiology] MH - Quality of Life MH - Reoperation MH - Retrospective Studies MH - Surgical Mesh/ae [Adverse Effects] MH - *Surgical Mesh MH - Surveys and Questionnaires KW - Direct-to-implant; Immediate breast reconstruction AB - BACKGROUND: Acellular dermal matrices have been used for direct-to-implant (DTI) breast reconstruction (BR), eliminating the load of the lower pole skin envelope. However, the available allograft matrices add considerable health care costs. This study examined the long-term follow-up of synthetic ULTRAPRO mesh as a low-cost potential alternative to biological matrices. AB - PATIENTS AND METHODS: A retrospective cohort study was performed between January 2013 and January 2016, involved 112 early-stage breast cancer and/or BRCA 1/2 patients, and evaluated 189 immediate DTI BRs following skin-, areola- or nipple-sparing mastectomy using ULTRAPRO mesh. Patient characteristics and postoperative complications were recorded, and quality of life was rated by the patients using the EORTC-QLQ-C30-BR23 questionnaire. Aesthetic outcomes and palpability of the implants were evaluated by four breast surgeons on a 5-point Likert scale. All recorded parameters were statistically analysed. AB - RESULTS: Ten patients were lost-to-follow-up, resulting in 102 patients and 174 breast surgery cases analysed. The mean age was 43 years, with 23.4 months of follow-up on average. Forty-six patients (45.1%) had previous radiotherapy with pre-existing scars. In total, 32 complications (18.3%) were recorded, including 12 minor (6.9%) and 20 major (11.4%) complications requiring revision. All median quality of life scores were above 83 points, representing a high score, with an average 4-point rating for the aesthetic outcome and natural consistency of the breast. AB - CONCLUSION: Partially absorbable ULTRAPRO mesh could be used successfully in DTI BR, offering a safe, less expensive alternative to biological matrices. Adequate indications and patient selection are necessary. Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(17)30332-3 DO - https://dx.doi.org/10.1016/j.ejso.2017.01.236 PT - Journal Article ID - S0748-7983(17)30332-3 [pii] ID - 10.1016/j.ejso.2017.01.236 [doi] PP - ppublish PH - 2016/09/21 [received] PH - 2016/12/04 [revised] PH - 2017/01/03 [accepted] LG - English EP - 20170206 DP - 2017 Jul EZ - 2017/02/22 06:00 DA - 2017/08/19 06:00 DT - 2017/02/21 06:00 YR - 2017 ED - 20170818 RD - 20170818 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28215734 <51. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26578432 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Van Eps J AU - Fernandez-Moure J AU - Cabrera F AU - Wang X AU - Karim A AU - Corradetti B AU - Chan P AU - Dunkin B AU - Tasciotti E AU - Weiner B AU - Ellsworth W 4th FA - Van Eps, Jeffrey FA - Fernandez-Moure, Joseph FA - Cabrera, Fernando FA - Wang, Xin FA - Karim, Azim FA - Corradetti, Bruna FA - Chan, Paige FA - Dunkin, Brian FA - Tasciotti, Ennio FA - Weiner, Bradley FA - Ellsworth, Warren 4th IN - Van Eps, Jeffrey. Department of Surgery, Houston Methodist Hospital, Houston, TX, 77030, USA. IN - Van Eps, Jeffrey. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Fernandez-Moure, Joseph. Department of Surgery, Houston Methodist Hospital, Houston, TX, 77030, USA. IN - Fernandez-Moure, Joseph. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Cabrera, Fernando. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Wang, Xin. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Karim, Azim. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Corradetti, Bruna. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Corradetti, Bruna. Department of Life and Environmental Sciences, Universita Politecnica delle Marche, Via Brecce Bianche, 60131, Ancona, Italy. IN - Chan, Paige. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Dunkin, Brian. Department of Surgery, Houston Methodist Hospital, Houston, TX, 77030, USA. IN - Dunkin, Brian. Methodist Institute for Technology, Innovation, and Education (MITIE), Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Dunkin, Brian. Weill Cornell Medical College, Cornell University, New York, NY, 10021, USA. IN - Tasciotti, Ennio. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. IN - Weiner, Bradley. Surgical Advanced Technologies Lab, Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. bkweiner@houstonmethodist.org. IN - Weiner, Bradley. Weill Cornell Medical College, Cornell University, New York, NY, 10021, USA. bkweiner@houstonmethodist.org. IN - Weiner, Bradley. Houston Methodist Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston, TX, 77030, USA. bkweiner@houstonmethodist.org. IN - Ellsworth, Warren 4th. Department of Surgery, Houston Methodist Hospital, Houston, TX, 77030, USA. IN - Ellsworth, Warren 4th. Weill Cornell Medical College, Cornell University, New York, NY, 10021, USA. TI - Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with StratticeTM mesh in a rodent ventral hernia model. SO - Surgical Endoscopy. 30(8):3239-49, 2016 08 AS - Surg Endosc. 30(8):3239-49, 2016 08 NJ - Surgical endoscopy VO - 30 IP - 8 PG - 3239-49 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - vbf, 8806653 IO - Surg Endosc PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956706 SB - Index Medicus CP - Germany MH - Acellular Dermis MH - Animals MH - *Collagen MH - Disease Models, Animal MH - *Hernia, Ventral/su [Surgery] MH - *Herniorrhaphy/mt [Methods] MH - Models, Anatomic MH - *Platelet-Rich Plasma MH - Postoperative Complications/ep [Epidemiology] MH - Prostheses and Implants MH - Rats MH - Rats, Inbred Lew MH - Recurrence MH - *Surgical Mesh MH - Tissue Adhesions/ep [Epidemiology] KW - *Hernia; *Platelet-rich plasma; *Recurrence; *Regeneration; *Strattice; *Ventral hernia repair AB - BACKGROUND: Recurrence after ventral hernia repair (VHR) remains a multifactorial problem still plaguing surgeons today. Some of the many contributing factors include mechanical strain, poor tissue-mesh integration, and degradation of matrices. The high recurrence rate witnessed with the use of acellular dermal matrices (ADM) for definitive hernia repair has reduced their use largely to bridging repair and breast reconstruction. Modalities that improve classic cellular metrics of successful VHR could theoretically result in improved rates of hernia recurrence; autologous platelet-rich plasma (PRP) may represent one such tool, but has been underinvestigated for this purpose. AB - METHODS: Lewis rats (32) had chronic ventral hernias created surgically and then repaired with StratticeTM mesh alone (control) or mesh + autologous PRP. Samples were harvested at 3 and 6 months postoperatively and compared for gross, histologic, and molecular outcomes of: neovascularization, tissue incorporation, peritoneal adhesions, hernia recurrence, and residual mesh thickness. AB - RESULTS: Compared to control at 3 months postoperatively, PRP-treated rats displayed significantly more neovascularization of implanted mesh and considerable upregulation of both angiogenic genes (vEGF 2.73-fold, vWF 2.21-fold) and myofibroblastic genes (alphaSMA 9.68-fold, FSP-1 3.61-fold, Col1a1 3.32-fold, Col31a1 3.29-fold). Histologically, they also showed enhanced tissue deposition/ingrowth and diminished chronic immune cell infiltration. Peritoneal adhesions were less severe at both 3 (1.88 vs. 2.94) and 6 months (1.63 vs. 2.75) by Modified Hopkins Adhesion Scoring. PRP-treated rats experienced decreased hernia recurrence at 6 months (0/10 vs. 7/10) and had significantly improved ADM preservation as evidenced by quantification of residual mesh thickness. AB - CONCLUSIONS: PRP is an autologous source of pro-regenerative growth factors and chemokines uniquely suited to soft tissue wound healing. When applied to a model of chronic VHR, it incites enhanced angiogenesis, myofibroblast recruitment and tissue ingrowth, ADM preservation, less severe peritoneal adhesions, and diminished hernia recurrence. We advocate further investigation regarding PRP augmentation of human VHR. RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1432-2218 IL - 0930-2794 DO - https://dx.doi.org/10.1007/s00464-015-4645-4 PT - Journal Article ID - 10.1007/s00464-015-4645-4 [doi] ID - 10.1007/s00464-015-4645-4 [pii] ID - PMC4956706 [pmc] PP - ppublish PH - 2015/05/20 [received] PH - 2015/10/24 [accepted] LG - English EP - 20151117 DP - 2016 08 EZ - 2015/11/19 06:00 DA - 2017/08/11 06:00 DT - 2015/11/19 06:00 YR - 2016 ED - 20170810 RD - 20180125 UP - 20180125 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=26578432 <52. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28350687 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA FA - Salzberg, C Andrew IN - Salzberg, C Andrew. Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. TI - Reply: Acellular Dermal Matrix-Assisted Direct-to-Implant Breast Reconstruction and Capsular Contracture: A 13-Year Experience. CM - Comment on: Plast Reconstr Surg. 2017 Apr;139(4):1014e-1015e; PMID: 28002277 SO - Plastic & Reconstructive Surgery. 139(4):1015e-1016e, 2017 04 AS - Plast Reconstr Surg. 139(4):1015e-1016e, 2017 04 NJ - Plastic and reconstructive surgery VO - 139 IP - 4 PG - 1015e-1016e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Collagen MH - Contracture/su [Surgery] MH - Humans MH - Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003192 PT - Letter PT - Comment ID - 10.1097/PRS.0000000000003192 [doi] ID - 00006534-201704000-00051 [pii] PP - ppublish LG - English DP - 2017 04 EZ - 2017/03/30 06:00 DA - 2017/08/11 06:00 DT - 2017/03/29 06:00 YR - 2017 ED - 20170810 RD - 20170810 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28350687 <53. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28234812 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Brown MH FA - Brown, Mitchell H IN - Brown, Mitchell H. Toronto, Ontario, Canada From the Department of Surgery, University of Toronto. TI - Discussion: Comparison of Different Acellular Dermal Matrices in Breast Reconstruction: The 50/50 Study. CM - Comment on: Plast Reconstr Surg. 2017 Mar;139(3):521-528; PMID: 28234811 SO - Plastic & Reconstructive Surgery. 139(3):529-530, 2017 03 AS - Plast Reconstr Surg. 139(3):529-530, 2017 03 NJ - Plastic and reconstructive surgery VO - 139 IP - 3 PG - 529-530 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Breast Implants MH - Collagen MH - Humans MH - *Mammaplasty RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003049 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000003049 [doi] ID - 00006534-201703000-00002 [pii] PP - ppublish LG - English DP - 2017 03 EZ - 2017/02/25 06:00 DA - 2017/08/11 06:00 DT - 2017/02/25 06:00 YR - 2017 ED - 20170810 RD - 20170810 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28234812 <54. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28002277 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Barone M AU - Cogliandro A AU - Persichetti P FA - Barone, Mauro FA - Cogliandro, Annalisa FA - Persichetti, Paolo IN - Barone, Mauro. Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University, Rome, Italy. TI - Use of Acellular Dermal Matrix in Breast Surgery: Our Experience and Analysis of Satisfaction Using BREAST-Q. CM - Comment in: Plast Reconstr Surg. 2017 Apr;139(4):1015e-1016e; PMID: 28350687 CM - Comment on: Plast Reconstr Surg. 2016 Aug;138(2):329-37; PMID: 27064232 SO - Plastic & Reconstructive Surgery. 139(4):1014e-1015e, 2017 04 AS - Plast Reconstr Surg. 139(4):1014e-1015e, 2017 04 NJ - Plastic and reconstructive surgery VO - 139 IP - 4 PG - 1014e-1015e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast MH - Humans MH - Mammaplasty MH - Mastectomy MH - *Personal Satisfaction ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003191 PT - Letter PT - Comment ID - 10.1097/PRS.0000000000003191 [doi] PP - ppublish LG - English DP - 2017 04 EZ - 2016/12/22 06:00 DA - 2017/08/11 06:00 DT - 2016/12/22 06:00 YR - 2017 ED - 20170810 RD - 20170810 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28002277 <55. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28347699 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jin US AU - Hong KY AU - Hwang YI FA - Jin, Ung Sik FA - Hong, Ki Yong FA - Hwang, Young-Il IN - Jin, Ung Sik. Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea. IN - Hong, Ki Yong. Department of Plastic and Reconstructive Surgery, Dongguk University Medical Center, Dongguk University School of Medicine, Republic of Korea. IN - Hwang, Young-Il. Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: hyi830@snu.ac.kr. TI - Effect of adipose-derived stem cells on acellular dermal matrix engraftment in a rabbit model of breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 70(6):806-813, 2017 Jun AS - J Plast Reconstr Aesthet Surg. 70(6):806-813, 2017 Jun NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 70 IP - 6 PG - 806-813 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - *Adipose Tissue/cy [Cytology] MH - Animals MH - *Breast Implantation/mt [Methods] MH - Female MH - Fibroblasts/me [Metabolism] MH - Gene Expression MH - Humans MH - Lymphocytes/me [Metabolism] MH - Neovascularization, Physiologic MH - Rabbits MH - *Stem Cells MH - Vimentin/me [Metabolism] KW - Acellular dermal matrix; Adipose-derived stem cell; Breast implant; Breast reconstruction AB - Acellular dermal matrix (ADM) is frequently used in implant-based breast reconstruction. Although there are several advantages, ADM implantation also increases the risk of certain complications. Recently, ADM seeded with adipose-derived stem cells (ADSCs) were shown to induce angiogenesis and improve wound healing. This study aimed to investigate the effects of ADSCs on ADM engraftment in a rabbit model of implant-based breast reconstruction. Silicone implants were inserted to submuscular pocket of 16 female New Zealand rabbits using ADM with or without seeding of fluorescent PKH26-labelled rabbit ADSCs. The marginal and central ADMs in each group were evaluated at 1 and 3 months after insertion. We performed a histological analysis including the number of CD31⁺ blood vessels, vimentin⁺ fibroblasts and lymphocytes; live/dead analysis; and gene expression analysis related to angiogenesis, inflammation and hypoxia. The implant was exposed in one rabbit with ADM without ADSCs during the study period. At 1 month, a histological analysis revealed more blood vessels and fibroblasts and reduced immune cell infiltration in marginal ADM with ADSCs. At 3 months, only angiogenesis was histologically different between groups. Conversely, cellularity was not significantly different in the central ADM between groups at month 1 or 3. ADSC supplementation increased the gene expression level associated with angiogenesis and inflammation, but not hypoxia. PKH26-labelled ADSCs were observed in both marginal and central ADMs at month 3. ADM seeded with ADSCs might be useful in promoting early incorporation with recipient tissue. This study supports the potential of ADM seeded with ADSCs as a reliable material for implant-based breast reconstruction. Copyright © 2017. Published by Elsevier Ltd. RN - 0 (Vimentin) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30095-5 DO - https://dx.doi.org/10.1016/j.bjps.2017.02.016 PT - Journal Article ID - S1748-6815(17)30095-5 [pii] ID - 10.1016/j.bjps.2017.02.016 [doi] PP - ppublish PH - 2016/08/12 [received] PH - 2017/02/12 [revised] PH - 2017/02/17 [accepted] LG - English EP - 20170228 DP - 2017 Jun EZ - 2017/03/30 06:00 DA - 2017/08/05 06:00 DT - 2017/03/29 06:00 YR - 2017 ED - 20170803 RD - 20170803 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28347699 <56. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27106640 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Phillips BT AU - Fourman MS AU - Bishawi M AU - Zegers M AU - O'Hea BJ AU - Ganz JC AU - Huston TL AU - Dagum AB AU - Khan SU AU - Bui DT FA - Phillips, Brett T FA - Fourman, Mitchell S FA - Bishawi, Muath FA - Zegers, Mary FA - O'Hea, Brian J FA - Ganz, Jason C FA - Huston, Tara L FA - Dagum, Alexander B FA - Khan, Sami U FA - Bui, Duc T IN - Phillips, Brett T. Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Hospital, Durham, NC. Electronic address: brett.phillips@duke.edu. IN - Fourman, Mitchell S. Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. IN - Bishawi, Muath. Division of Cardiovascular and Thoracic Surgery, Duke University Hospital, Durham, NC. IN - Zegers, Mary. Department of Surgery, Stony Brook University Hospital, Stony Brook, NY. IN - O'Hea, Brian J. Division of Breast Surgery, Stony Brook University Hospital, Stony Brook, NY. IN - Ganz, Jason C. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook, NY. IN - Huston, Tara L. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook, NY. IN - Dagum, Alexander B. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook, NY. IN - Khan, Sami U. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook, NY. IN - Bui, Duc T. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook, NY. TI - Are Prophylactic Postoperative Antibiotics Necessary for Immediate Breast Reconstruction? Results of a Prospective Randomized Clinical Trial. SO - Journal of the American College of Surgeons. 222(6):1116-24, 2016 Jun AS - J Am Coll Surg. 222(6):1116-24, 2016 Jun NJ - Journal of the American College of Surgeons VO - 222 IP - 6 PG - 1116-24 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - bzb, 9431305 IO - J. Am. Coll. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Administration, Oral MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Anti-Bacterial Agents/ad [Administration & Dosage] MH - Anti-Bacterial Agents/tu [Therapeutic Use] MH - *Antibiotic Prophylaxis/mt [Methods] MH - *Cefazolin/ad [Administration & Dosage] MH - Cefazolin/tu [Therapeutic Use] MH - *Clindamycin/ad [Administration & Dosage] MH - Clindamycin/tu [Therapeutic Use] MH - Drug Administration Schedule MH - Female MH - Humans MH - Infusions, Intravenous MH - Mammaplasty/mt [Methods] MH - *Mammaplasty MH - Mastectomy MH - Middle Aged MH - *Postoperative Care/mt [Methods] MH - Prospective Studies MH - Surgical Wound Infection/di [Diagnosis] MH - Surgical Wound Infection/ep [Epidemiology] MH - *Surgical Wound Infection/pc [Prevention & Control] MH - Treatment Outcome MH - Young Adult AB - BACKGROUND: Closed-suction drains, implants, and acellular dermal matrix (ADM) are routinely used in tissue expander-based immediate breast reconstruction (TE-IBR). Each of these factors is thought to increase the potential for surgical site infection (SSI). Although CDC guidelines recommend only 24 hours of antibiotic prophylaxis after TE-IBR, current clinical practices vary significantly. This study evaluated the difference in SSI between 2 different prophylactic antibiotic durations. AB - STUDY DESIGN: A noninferiority randomized controlled trial was designed in which TE-IBR patients received antibiotics either 24 hours postoperatively or until drain removal. The primary outcome was SSI, as defined by CDC criteria. Operative and postoperative protocols were standardized. Secondary endpoints included clinical outcomes up to 1 year and all implant loss, or reoperation. AB - RESULTS: There were 112 TE-IBR patients (180 breasts) using ADM who were randomized into 2 study arms, with 62 patients in the 24-hour group and 50 in the extended group. Surgical site infection was diagnosed in 12 patients in the 24-hour group and 11 in the extended group (19.4% vs 22.0%, p = 0.82). The extended group had 7 patients who required IV antibiotics and an overall implant loss in 7 patients (14.0%). The 24-hour group had 4 patients who required IV antibiotics, with 3 requiring removal (4.8%). Patients with diabetes, postoperative seroma, or wound dehiscence were all more likely to develop SSI (p < 0.02). AB - CONCLUSIONS: In a randomized controlled noninferiority trial, 24 hours of antibiotics is equivalent to extended oral antibiotics for SSI in TE-IBR patients. Additional multicenter trials will further assess this important aspect of TE-IBR postoperative care. Copyright © 2016 American College of Surgeons. Published by Elsevier Inc. All rights reserved. RN - 0 (Anti-Bacterial Agents) RN - 3U02EL437C (Clindamycin) RN - IHS69L0Y4T (Cefazolin) ES - 1879-1190 IL - 1072-7515 DI - S1072-7515(16)00193-9 DO - https://dx.doi.org/10.1016/j.jamcollsurg.2016.02.018 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial ID - S1072-7515(16)00193-9 [pii] ID - 10.1016/j.jamcollsurg.2016.02.018 [doi] PP - ppublish PH - 2015/11/09 [received] PH - 2016/02/17 [revised] PH - 2016/02/17 [accepted] LG - English EP - 20160304 DP - 2016 Jun EZ - 2016/04/24 06:00 DA - 2017/07/22 06:00 DT - 2016/04/24 06:00 YR - 2016 ED - 20170721 RD - 20170721 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27106640 <57. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27232716 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fischer S AU - Hirche C AU - Diehm Y AU - Nuutila K AU - Kiefer J AU - Gazyakan E AU - Bueno EM AU - Kremer T AU - Kneser U AU - Pomahac B FA - Fischer, Sebastian FA - Hirche, Christoph FA - Diehm, Yannick FA - Nuutila, Kristo FA - Kiefer, Jurij FA - Gazyakan, Emre FA - Bueno, Ericka M FA - Kremer, Thomas FA - Kneser, Ulrich FA - Pomahac, Bohdan IN - Fischer, Sebastian. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. IN - Fischer, Sebastian. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Hirche, Christoph. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Diehm, Yannick. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. IN - Diehm, Yannick. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Nuutila, Kristo. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. IN - Kiefer, Jurij. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Gazyakan, Emre. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Bueno, Ericka M. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. IN - Kremer, Thomas. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Kneser, Ulrich. Department of Hand-, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany. IN - Pomahac, Bohdan. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. TI - Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. SO - PLoS ONE [Electronic Resource]. 11(5):e0156428, 2016 AS - PLoS ONE. 11(5):e0156428, 2016 NJ - PloS one VO - 11 IP - 5 PG - e0156428 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Internet JC - 101285081 IO - PLoS ONE PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883774 SB - Index Medicus CP - United States MH - *Breast Implants/ae [Adverse Effects] MH - Collagen/me [Metabolism] MH - Dose-Response Relationship, Drug MH - Female MH - Humans MH - Implant Capsular Contracture/dt [Drug Therapy] MH - Implant Capsular Contracture/et [Etiology] MH - *Implant Capsular Contracture/pa [Pathology] MH - *Microbial Collagenase/pd [Pharmacology] MH - Microbial Collagenase/tu [Therapeutic Use] MH - *Silicone Gels/ae [Adverse Effects] MH - Skin/de [Drug Effects] MH - Skin/me [Metabolism] AB - BACKGROUND: The fibrotic capsule that surrounds silicone implants consists mainly of collagen. The FDA-approved collagenase of the bacterium clostridium histolyticum provides a reasonable treatment option. Safety and efficacy at the female breast site must be evaluated before clinical utilization. AB - MATERIALS AND METHODS: We incubated 20 samples of fibrotic capsule as well as 12 full thickness skin grafts harvested from the female breast site for 24 hours with different doses of collagenase. Outcome measures involved histological assessment of thickness and density of the capsule tissue as well as the skin grafts. Furthermore, we performed a collagen assay and immunohistochemistry staining for collagen subtypes. AB - RESULTS: Collagenase treatment was able to degrade human capsule contracture tissue ex-vivo. The remaining collagen subtype after degradation was type 4 only. 0.3 mg/ml of collagenase was most effective in reducing capsule thickness when compared with higher concentrations. Of note, effectiveness was inversely related to capsule density, such that there was less reduction in thickness with higher capsule densities and vice versa. Furthermore, the application of 0.3mg/ml collagenase did not lead to thinning or perforation of full thickness skin grafts. AB - CONCLUSION: Adjustment of collagenase dose will depend on thickness and density of the contracted capsule. A concentration of 0.3mg/ml seems to be safe and effective in an ex-vivo setting. The remaining collagen subtype 4 is suitable to serve as a neo-capsule/acellular tissue matrix. Collagenase treatment for capsular contracture may soon become a clinical reality. RN - 0 (Silicone Gels) RN - 9007-34-5 (Collagen) RN - EC 3-4-24-3 (Microbial Collagenase) ES - 1932-6203 IL - 1932-6203 DO - https://dx.doi.org/10.1371/journal.pone.0156428 PT - Journal Article ID - 10.1371/journal.pone.0156428 [doi] ID - PONE-D-16-06403 [pii] ID - PMC4883774 [pmc] PP - epublish PH - 2016/02/18 [received] PH - 2016/05/14 [accepted] LG - English EP - 20160527 DP - 2016 EZ - 2016/05/28 06:00 DA - 2017/07/20 06:00 DT - 2016/05/28 06:00 YR - 2016 ED - 20170719 RD - 20170719 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27232716 <58. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26881927 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Skovsted Yde S AU - Brunbjerg ME AU - Damsgaard TE FA - Skovsted Yde, Simon FA - Brunbjerg, Mette Eline FA - Damsgaard, Tine Engberg IN - Skovsted Yde, Simon. a Plastic Surgical Research Unit, Department of Plastic Surgery , Aarhus University Hospital , Aarhus , Denmark. IN - Brunbjerg, Mette Eline. a Plastic Surgical Research Unit, Department of Plastic Surgery , Aarhus University Hospital , Aarhus , Denmark. IN - Damsgaard, Tine Engberg. a Plastic Surgical Research Unit, Department of Plastic Surgery , Aarhus University Hospital , Aarhus , Denmark. TI - Acellular dermal matrices in breast reconstructions - a literature review. [Review] SO - Journal of Plastic Surgery and Hand Surgery. 50(4):187-96, 2016 Aug AS - J Plast Surg Hand Surg. 50(4):187-96, 2016 Aug NJ - Journal of plastic surgery and hand surgery VO - 50 IP - 4 PG - 187-96 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg SB - Index Medicus CP - Sweden MH - *Acellular Dermis MH - Collagen/ae [Adverse Effects] MH - Humans MH - *Mammaplasty/mt [Methods] MH - Postoperative Complications KW - Acellular dermal matrix; breast reconstruction; postoperative complications AB - During the last two decades, acellular dermal matrices (ADM) have been more widely used in reconstructive procedures i.e. breast reconstructions. Several, both synthetic and biologic products derived from human, porcine and bovine tissue, have been introduced. Until this point postoperative complications for the acellular dermal matrices, as a group, have been the main focus. The purpose of this literature review is to summarize the current knowledge on the each biologic product used in breast reconstructions, including product specific complication frequencies. A systematic search of the literature was performed in the PubMed and EMBASE databases, identifying 55 relevant articles, mainly evidence level III. AlloDerm seems to be associated with severe complicating matters in the reconstructive process compared to other products. This could be due to the higher number of investigating studies relative to the others. The surgical area faces certain challenges comparing results, due to surgical variance, the data collection and follow-up. More well-defined guidelines and more high-evidence randomized studies could increase the overall level of evidence in this area. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.3109/2000656X.2016.1140053 PT - Journal Article PT - Review ID - 10.3109/2000656X.2016.1140053 [doi] PP - ppublish LG - English EP - 20160216 DP - 2016 Aug EZ - 2016/02/18 06:00 DA - 2017/07/18 06:00 DT - 2016/02/17 06:00 YR - 2016 ED - 20170717 RD - 20170717 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26881927 <59. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27465157 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Loma Linda, Calif. From the Department of Plastic Surgery, Loma Linda University Medical Center. TI - Discussion: Acellular Dermal Matrix-Assisted Direct-to-Implant Breast Reconstruction and Capsular Contracture: A 13-Year Experience. CM - Comment on: Plast Reconstr Surg. 2016 Aug;138(2):329-37; PMID: 27064232 SO - Plastic & Reconstructive Surgery. 138(2):338-9, 2016 08 AS - Plast Reconstr Surg. 138(2):338-9, 2016 08 NJ - Plastic and reconstructive surgery VO - 138 IP - 2 PG - 338-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Contracture/su [Surgery] MH - Humans MH - Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002422 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000002422 [doi] ID - 00006534-201608000-00002 [pii] PP - ppublish LG - English DP - 2016 08 EZ - 2016/07/29 06:00 DA - 2017/07/14 06:00 DT - 2016/07/29 06:00 YR - 2016 ED - 20170712 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27465157 <60. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27351473 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hoffman L AU - Small K AU - Talmor M FA - Hoffman, Lloyd FA - Small, Kevin FA - Talmor, Mia IN - Hoffman, Lloyd. Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, N.Y. TI - Use of Acellular Dermal Matrix in Postmastectomy Breast Reconstruction: Are All Acellular Dermal Matrices Created Equal?. CM - Comment in: Plast Reconstr Surg. 2016 Jul;138(1):149e-50e; PMID: 27351474 CM - Comment on: Plast Reconstr Surg. 2015 Oct;136(4):647-53; PMID: 26397242 SO - Plastic & Reconstructive Surgery. 138(1):148e-9e, 2016 07 AS - Plast Reconstr Surg. 138(1):148e-9e, 2016 07 NJ - Plastic and reconstructive surgery VO - 138 IP - 1 PG - 148e-9e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Breast Implantation MH - Collagen MH - Humans MH - *Mammaplasty RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002274 PT - Letter PT - Comment ID - 10.1097/PRS.0000000000002274 [doi] ID - 00006534-201607000-00065 [pii] PP - ppublish LG - English DP - 2016 07 EZ - 2016/06/29 06:00 DA - 2017/07/14 06:00 DT - 2016/06/29 06:00 YR - 2016 ED - 20170710 RD - 20171025 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27351473 <61. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28051266 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maruccia M AU - Mazzocchi M AU - Dessy LA AU - Onesti MG FA - Maruccia, M FA - Mazzocchi, M FA - Dessy, L A FA - Onesti, M G IN - Maruccia, M. Department of Surgery "P. Valdoni", Unit of Plastic and Reconstructive Surgery Sapienza University, Rome, Italy. marucciam@gmail.com. TI - One-stage breast reconstruction techniques in elderly patients to preserve quality of life. SO - European Review for Medical & Pharmacological Sciences. 20(24):5058-5066, 2016 12 AS - Eur Rev Med Pharmacol Sci. 20(24):5058-5066, 2016 12 NJ - European review for medical and pharmacological sciences VO - 20 IP - 24 PG - 5058-5066 PI - Journal available in: Print PI - Citation processed from: Internet JC - cyu, 9717360 IO - Eur Rev Med Pharmacol Sci SB - Index Medicus CP - Italy MH - Acellular Dermis MH - Aged MH - *Breast Implants MH - Breast Neoplasms/px [Psychology] MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mammaplasty MH - Mastectomy MH - *Quality of Life MH - Retrospective Studies AB - OBJECTIVE: The aim of this study was to review one-stage breast reconstruction techniques performed in elderly patients at our institution to identify the criteria of selection of each in terms of outcomes and quality of life. AB - PATIENTS AND METHODS: Patients older than 65 years who underwent one-stage breast reconstruction between January 2004 and July 2014 at our hospital were included. Patients and procedure-related data were collected from the medical records. In particular, patient's age, comorbidities and related ASA physical status, type of one-stage breast reconstruction technique, and criteria of selection were analyzed. Outcomes and results were also evaluated in terms of quality of life using the EORTC QLQ-C30 and -BR23 questionnaires 1 year after surgery. AB - RESULTS: A total of 840 women underwent breast reconstruction, of whom 138 elderly women received one-stage breast reconstruction. There were 118 cases (85.5%) of monolateral reconstructions and 20 cases (14.5%) of bilateral reconstructions, resulting in 138 breast reconstructions. These were performed with permanent inflatable expanders in the sub-muscular position (Group A, n= 50), with acellular dermal matrix and partial sub-muscular anatomic implant (Group B, n= 50), and with Braxon acellular dermal matrix and anatomic implant with muscle-sparing technique (Group C, n= 38). The EORTC questionnaires showed the best results in Group C regarding the quality of life. AB - CONCLUSIONS: The elderly population is rapidly increasing, and 50% of all breast cancers occur in women older than 65 years; among them, only 2% undergo breast reconstruction. A major aspect of breast cancer treatment and subsequent quality of life is the opportunity for a post-mastectomy reconstructive surgery. As survival rates are improving, a larger proportion of patients live with the long-term consequences of their treatment, and breast reconstruction ensures a better quality of life. To increase the reconstruction rates, surgery should be one-stage, less invasive as possible, allowing rapid recovery, especially in elderly women, in whom comorbidities are often present with a higher anaesthetic risk. Our study highlighted that non-skin sparing mastectomy (SSM) and delayed reconstructions should be addressed with Becker implants; immediate reconstructions after SSM should be followed by acellular dermal matrix (ADM)-assisted implant reconstruction, preferring the wrap technique offers a better quality of life in elderly patients. ES - 2284-0729 IL - 1128-3602 DI - 11912 PT - Journal Article PP - ppublish LG - English DP - 2016 12 EZ - 2017/01/05 06:00 DA - 2017/06/28 06:00 DT - 2017/01/05 06:00 YR - 2016 ED - 20170627 RD - 20180318 UP - 20180319 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=28051266 <62. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28121875 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - DeGeorge BR Jr AU - Ning B AU - Salopek LS AU - Pineros-Fernandez A AU - Rodeheaver GT AU - Peirce-Cottler S AU - Hu S AU - Cottler PS AU - Campbell CA FA - DeGeorge, Brent R Jr FA - Ning, Bo FA - Salopek, Lisa S FA - Pineros-Fernandez, Angela FA - Rodeheaver, George T FA - Peirce-Cottler, Shayn FA - Hu, Song FA - Cottler, Patrick S FA - Campbell, Christopher A IN - DeGeorge, Brent R Jr. Charlottesville, Va. From the Departments of Plastic Surgery and Biomedical Engineering, University of Virginia. TI - Advanced Imaging Techniques for Investigation of Acellular Dermal Matrix Biointegration. SO - Plastic & Reconstructive Surgery. 139(2):395-405, 2017 Feb AS - Plast Reconstr Surg. 139(2):395-405, 2017 Feb NJ - Plastic and reconstructive surgery VO - 139 IP - 2 PG - 395-405 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - Biological Phenomena MH - *Inflammation/dg [Diagnostic Imaging] MH - Mice MH - Microscopy MH - *Neovascularization, Physiologic MH - Photoacoustic Techniques AB - BACKGROUND: Biointegration, a concept involving a dynamic interplay among three processes-inflammation, cellular infiltration, and angiogenesis-is key to understanding the interaction between acellular dermal matrices and the host. The current standard for evaluating acellular dermal matrix biointegration involves histologic analysis at fixed time points; however, the authors' approach uses advanced imaging techniques to serially assess biointegration in real time. AB - METHODS: The authors have adapted two advanced imaging techniques-two-photon microscopy and photoacoustic microscopy-to investigate biointegration in a murine deepithelialized dorsal skin-fold window chamber model, specifically engineered to recapitulate the host microenvironment of acellular dermal matrix-assisted breast reconstruction. Four mice per group were assessed. Two-photon imaging of dual-transgenic mice allows for detection of fluorescently labeled perivascular cells, and macrophage lineage cells. Photoacoustic microscopy noninvasively assesses oxygen and hemoglobin concentration in living tissues, generating high-resolution, three-dimensional mapping of the nascent acellular dermal matrix-associated microvasculature and metabolic consumption of oxygen. These outcomes were corroborated by confirmatory histologic analysis at the terminal time point. AB - RESULTS: The acellular dermal matrix/host interface is characterized by robust inflammation (0 to 3 days), increased oxygen consumption and neoangiogenesis in the matrix border zone (10 to 14 days), and vascular and inflammatory cell penetration into the center of the matrix (>21 days). AB - CONCLUSION: The data broaden the core knowledge of acellular dermal matrix biology, and serve as a potential template for elucidating the key differences among various commercially available and developmental products to guide the reconstructive surgeon to better select a reconstructive adjunct that meets their specific needs. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002992 PT - Journal Article ID - 10.1097/PRS.0000000000002992 [doi] ID - 00006534-201702000-00026 [pii] PP - ppublish LG - English DP - 2017 Feb EZ - 2017/01/26 06:00 DA - 2017/06/14 06:00 DT - 2017/01/26 06:00 YR - 2017 ED - 20170613 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28121875 <63. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28027223 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salibian AH AU - Harness JK AU - Mowlds DS FA - Salibian, Arthur H FA - Harness, Jay K FA - Mowlds, Donald S IN - Salibian, Arthur H. Orange, Calif. From St. Joseph Hospital and the Departments of Plastic Surgery and Surgery, University of California Irvine Medical Center. TI - Staged Suprapectoral Expander/Implant Reconstruction without Acellular Dermal Matrix following Nipple-Sparing Mastectomy. SO - Plastic & Reconstructive Surgery. 139(1):30-39, 2017 Jan AS - Plast Reconstr Surg. 139(1):30-39, 2017 Jan NJ - Plastic and reconstructive surgery VO - 139 IP - 1 PG - 30-39 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy, Subcutaneous MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications MH - Prospective Studies MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - BACKGROUND: Since the introduction of nipple-sparing mastectomy as an oncologically safe procedure for the treatment of breast cancer, reconstructive efforts for immediate staged expander/implant reconstruction have focused on submuscular implantation with or without acellular dermal matrix. Suprapectoral reconstruction without acellular dermal matrix has received little attention in the reconstructive literature of nipple-sparing mastectomy. AB - METHODS: Between 2005 and 2015, 155 patients (250 breasts) underwent nipple-sparing mastectomy with prepectoral staged expander/implant reconstruction using thick mastectomy skin flaps without acellular dermal matrix. Patients with different breast sizes, including those patients with very large breasts who required a primary mastopexy, were considered candidates for the suprapectoral reconstruction. Tumor-related data, comorbidities, and preoperative or postoperative radiation therapy were evaluated for correlation with the final outcome. AB - RESULTS: Patients were followed up for an average of 55.5 months (range, 138.1 to 23.6 months). The tumor recurrence rate was 2.6 percent. Adverse outcomes such as capsular contracture, implant dystopia, and rippling were studied. Aesthetic outcome, based on a three-point evaluation scale, showed 53.6 percent of patients as having a very good result, 31.6 percent showing a good result, 9 percent showing a fair result, and 5.8 percent showing a poor result. AB - CONCLUSIONS: The suprapectoral two-stage expander/implant reconstruction without acellular dermal matrix in nipple-sparing mastectomy has certain advantages with respect to breast shape, less morbidity related to expansion, ease of reconstruction, and cost effectiveness. These advantages have to be weighed against those of subpectoral reconstruction with acellular dermal matrix to determine the method of choice. AB - CLINCAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002845 PT - Clinical Trial PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0000000000002845 [doi] ID - 00006534-201701000-00007 [pii] PP - ppublish LG - English DP - 2017 Jan EZ - 2016/12/28 06:00 DA - 2017/06/07 06:00 DT - 2016/12/28 06:00 YR - 2017 ED - 20170606 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28027223 <64. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28012977 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dikmans RE AU - Negenborn VL AU - Bouman MB AU - Winters HA AU - Twisk JW AU - Ruhe PQ AU - Mureau MA AU - Smit JM AU - Tuinder S AU - Eltahir Y AU - Posch NA AU - van Steveninck-Barends JM AU - Meesters-Caberg MA AU - van der Hulst RR AU - Ritt MJ AU - Mullender MG FA - Dikmans, Rieky E G FA - Negenborn, Vera L FA - Bouman, Mark-Bram FA - Winters, Hay A H FA - Twisk, Jos W R FA - Ruhe, P Quinten FA - Mureau, Marc A M FA - Smit, Jan Maerten FA - Tuinder, Stefania FA - Eltahir, Yassir FA - Posch, Nicole A FA - van Steveninck-Barends, Josephina M FA - Meesters-Caberg, Marleen A FA - van der Hulst, Rene R W J FA - Ritt, Marco J P F FA - Mullender, Margriet G IN - Dikmans, Rieky E G. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, Netherlands. IN - Negenborn, Vera L. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, Netherlands. IN - Bouman, Mark-Bram. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, Netherlands; Alexander Monro Breast Cancer Hospital, Bilthoven, Netherlands. IN - Winters, Hay A H. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, Netherlands; Alexander Monro Breast Cancer Hospital, Bilthoven, Netherlands. IN - Twisk, Jos W R. Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, Netherlands. IN - Ruhe, P Quinten. Department of Plastic, Reconstructive, and Hand Surgery, Meander Medical Centre, Amersfoort, Netherlands. IN - Mureau, Marc A M. Department of Plastic, Reconstructive, and Hand Surgery, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, Netherlands. IN - Smit, Jan Maerten. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands; Alexander Monro Breast Cancer Hospital, Bilthoven, Netherlands. IN - Tuinder, Stefania. Department of Plastic, Reconstructive, and Hand Surgery, Maastricht University Medical Centre, Maastricht, Netherlands. IN - Eltahir, Yassir. Department of Plastic, Reconstructive, and Hand Surgery, University Medical Centre Groningen, Groningen, Netherlands. IN - Posch, Nicole A. Department of Plastic, Reconstructive, and Hand Surgery, Haga Ziekenhuis, Den Haag, Netherlands. IN - van Steveninck-Barends, Josephina M. Department of Plastic, Reconstructive, and Hand Surgery, Haga Ziekenhuis, Den Haag, Netherlands. IN - Meesters-Caberg, Marleen A. Department of Plastic, Reconstructive, and Hand Surgery, Orbis Medisch Centrum, Sittard, Netherlands. IN - van der Hulst, Rene R W J. Department of Plastic, Reconstructive, and Hand Surgery, Maastricht University Medical Centre, Maastricht, Netherlands. IN - Ritt, Marco J P F. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands. IN - Mullender, Margriet G. Department of Plastic, Reconstructive, and Hand Surgery, VU University Medical Centre, Amsterdam, Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, Netherlands. Electronic address: m.mullender@vumc.nl. TI - Two-stage implant-based breast reconstruction compared with immediate one-stage implant-based breast reconstruction augmented with an acellular dermal matrix: an open-label, phase 4, multicentre, randomised, controlled trial. SO - Lancet Oncology. 18(2):251-258, 2017 Feb AS - Lancet Oncol. 18(2):251-258, 2017 Feb NJ - The Lancet. Oncology VO - 18 IP - 2 PG - 251-258 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100957246 IO - Lancet Oncol. SB - Index Medicus CP - England MH - *Acellular Dermis/ut [Utilization] MH - Adult MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/pa [Pathology] MH - *Carcinoma, Ductal, Breast/su [Surgery] MH - Carcinoma, Intraductal, Noninfiltrating/pa [Pathology] MH - *Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - Carcinoma, Lobular/pa [Pathology] MH - *Carcinoma, Lobular/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Neoplasm Staging MH - Netherlands MH - Postoperative Complications MH - Prospective Studies MH - Quality of Life MH - Reoperation MH - Research Design MH - Treatment Outcome AB - BACKGROUND: The evidence justifying the use of acellular dermal matrices (ADMs) in implant-based breast reconstruction (IBBR) is limited. We did a prospective randomised trial to compare the safety of IBBR with an ADM immediately after mastectomy with that of two-stage IBBR. AB - METHODS: We did an open-label, randomised, controlled trial in eight hospitals in the Netherlands. Eligible women were older than 18 years with breast carcinoma or a gene mutation linked with breast cancer who intended to undergo skin-sparing mastectomy and immediate IBBR. Randomisation was done electronically, stratified per centre and in blocks of ten to achieve roughly balanced groups. Women were assigned to undergo one-stage IBBR with ADM (Strattice, LifeCell, Branchburg, NJ, USA) or two-stage IBBR. The primary endpoint was quality of life and safety was assessed by the occurrence of adverse outcomes. Analyses were done per protocol with logistic regression and generalised estimating equations. This study is registered at Nederlands Trial Register, number NTR5446. AB - FINDINGS: 142 women were enrolled between April 14, 2013, and May 29, 2015, of whom 59 (91 breasts) in the one-stage IBBR with ADM group and 62 (92 breasts) in the two-stage IBBR group were included in analyses. One-stage IBBR with ADM was associated with significantly higher risk per breast of surgical complications (crude odds ratio 3.81, 95% CI 2.67-5.43, p<0.001), reoperation (3.38, 2.10-5.45, p<0.001), and removal of implant, ADM, or both (8.80, 8.24-9.40, p<0.001) than two-stage IBBR. Severe (grade 3) adverse events occurred in 26 (29%) of 91 breasts in the one-stage IBBR with ADM group and in five (5%) of 92 in the two-stage IBBR group. The frequency of mild to moderate adverse events was similar in the two groups. AB - INTERPRETATION: Immediate one-stage IBBR with ADM was associated with adverse events and should be considered very carefully. Understanding of selection of patients, risk factors, and surgical and postsurgical procedures needs to be improved. AB - FUNDING: Pink Ribbon, Nuts-Ohra, and LifeCell. Copyright © 2017 Elsevier Ltd. All rights reserved. ES - 1474-5488 IL - 1470-2045 DI - S1470-2045(16)30668-4 DO - https://dx.doi.org/10.1016/S1470-2045(16)30668-4 PT - Clinical Trial, Phase IV PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial ID - S1470-2045(16)30668-4 [pii] ID - 10.1016/S1470-2045(16)30668-4 [doi] PP - ppublish PH - 2016/06/22 [received] PH - 2016/10/15 [revised] PH - 2016/10/18 [accepted] LG - English EP - 20161222 DP - 2017 Feb EZ - 2016/12/26 06:00 DA - 2017/06/06 06:00 DT - 2016/12/26 06:00 YR - 2017 ED - 20170605 RD - 20170605 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28012977 <65. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28350650 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Serrurier LC AU - Rayne S AU - Venter M AU - Benn CA FA - Serrurier, L Charles J FA - Rayne, Sarah FA - Venter, Marisse FA - Benn, Carol-Ann IN - Serrurier, L Charles J. Johannesburg, South Africa From the University of the Witwatersrand and Milpark Breast Care Centre of Excellence. TI - Direct-to-Implant Breast Reconstruction without the Use of an Acellular Dermal Matrix Is Cost Effective and Oncologically Safe. CM - Comment in: Plast Reconstr Surg. 2017 Dec;140(6):820e-821e; PMID: 28820815 CM - Comment in: Plast Reconstr Surg. 2017 Dec;140(6):821e-822e; PMID: 29176426 SO - Plastic & Reconstructive Surgery. 139(4):809-817, 2017 Apr AS - Plast Reconstr Surg. 139(4):809-817, 2017 Apr NJ - Plastic and reconstructive surgery VO - 139 IP - 4 PG - 809-817 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adolescent MH - Adult MH - Aged MH - *Breast Implantation/ec [Economics] MH - *Breast Neoplasms/su [Surgery] MH - *Cost-Benefit Analysis MH - Female MH - Humans MH - Mammaplasty/ec [Economics] MH - Mammaplasty/mt [Methods] MH - Middle Aged MH - Retrospective Studies MH - Time Factors MH - Young Adult AB - BACKGROUND: Direct-to-implant breast reconstruction is a predictable, reliable, and cost-effective reconstruction. Most units performing direct-to-implant reconstructions recommend the use of an acellular dermal matrix or a mesh to reinforce the lower pole of the breast reconstruction. AB - METHODS: Two hundred seventy-two consecutive patients with 488 immediate direct-to-implant breast reconstructions performed in a 34-month period are included in this group. Mean follow-up of this group is 35 months. AB - RESULTS: Four hundred eight reconstructions were performed through a lazy-S mastectomy, and 80 were performed through a Wise pattern mastectomy. Two local recurrences occurred. Minor complications accounted for 5.5 percent (n = 27): seromas, 3.4 percent (n = 17); wound healing problems, 0.6 percent (n = 3); and grade 2 capsular contracture, 1.4 percent (n = 7). Major complications accounted for 4.3 percent (n = 21): infection, 0.8 percent (n = 4); prosthetic loss, 0.4 percent (n = 2); hematoma, 0.4 percent (n = 2); and wounds requiring debridement, 2 percent (n = 10). The additional cost of acellular dermal matrix is dependent on manufacturer and size, but increases the cost of the procedure by 35.5 to 47.7 percent. AB - CONCLUSIONS: This reconstruction method compares very favorably with published data from other units as far as early and late complications and cosmetic outcome are concerned. It has a complication rate similar to that of reconstructions using an acellular dermal matrix and is more cost effective. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003222 PT - Journal Article ID - 10.1097/PRS.0000000000003222 [doi] ID - 00006534-201704000-00005 [pii] PP - ppublish LG - English DP - 2017 Apr EZ - 2017/03/30 06:00 DA - 2017/06/02 06:00 DT - 2017/03/29 06:00 YR - 2017 ED - 20170601 RD - 20171215 UP - 20171215 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=28350650 <66. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28234811 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Pittman TA AU - Fan KL AU - Knapp A AU - Frantz S AU - Spear SL FA - Pittman, Troy A FA - Fan, Kenneth L FA - Knapp, Andrew FA - Frantz, Shelby FA - Spear, Scott L IN - Pittman, Troy A. Washington, D.C. From the Department of Plastic Surgery, MedStar Georgetown University Hospital; Georgetown University School of Medicine; and private practice. TI - Comparison of Different Acellular Dermal Matrices in Breast Reconstruction: The 50/50 Study. CM - Comment in: Plast Reconstr Surg. 2017 Mar;139(3):529-530; PMID: 28234812 CM - Comment in: Plast Reconstr Surg. 2017 Nov;140(5):750e-751e; PMID: 29068953 CM - Comment in: Plast Reconstr Surg. 2017 Nov;140(5):751e; PMID: 29068954 SO - Plastic & Reconstructive Surgery. 139(3):521-528, 2017 Mar AS - Plast Reconstr Surg. 139(3):521-528, 2017 Mar NJ - Plastic and reconstructive surgery VO - 139 IP - 3 PG - 521-528 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Retrospective Studies AB - BACKGROUND: Acellular dermal matrix has enjoyed extensive use in primary and secondary alloplastic breast aesthetic and reconstructive surgery. The objective of this study was to examine clinical outcomes between available acellular dermal matrix products: DermACELL (LifeNet Health, Virginia Beach, Va.) and AlloDerm Ready To Use (LifeCell Corp., Branchburg, N.J.). AB - METHODS: A retrospective chart review was performed on 58 consecutive patients (100 breasts) reconstructed with either DermACELL (n = 30 patients; 50 breasts) or AlloDerm Ready To Use (n = 28 patients; 50 breasts). The mastectomies were performed by three different breast surgeons. All reconstructions were performed by the same plastic surgeon (T.A.P.). Statistical analysis was performed by means of Fisher's exact test. AB - RESULTS: Differences in the average age, body mass index, percentage having neoadjuvant/adjuvant chemotherapy or breast irradiation, and numbers of therapeutic and prophylactic mastectomies between the two groups were not statistically significant (p < 0.05). Complications in both cohorts of patients were clinically recorded for 90 days after immediate reconstruction. When comparing outcomes, patients in the DermACELL group had a significantly lower incidence of "red breast syndrome" (0 percent versus 26 percent; p = 0.0001) and fewer days before drain removal (15.8 days versus 20.6 days; p = 0.017). No significant differences were seen in terms of seroma, hematoma, delayed healing, infection, flap necrosis, or explantation. AB - CONCLUSION: Patients reconstructed with DermACELL as compared with AlloDerm Ready To Use have significantly decreased number of days to drain removal and red breast syndrome and equivalent rates of other complications, including seroma, infection, flap necrosis, and explantation. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003048 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0000000000003048 [doi] ID - 00006534-201703000-00001 [pii] PP - ppublish LG - English DP - 2017 Mar EZ - 2017/02/25 06:00 DA - 2017/06/02 06:00 DT - 2017/02/25 06:00 YR - 2017 ED - 20170601 RD - 20171215 UP - 20171215 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=28234811 <67. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27556599 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Krishnan NM AU - Fischer JP AU - Basta MN AU - Nahabedian MY FA - Krishnan, Naveen M FA - Fischer, John P FA - Basta, Marten N FA - Nahabedian, Maurice Y IN - Krishnan, Naveen M. Washington, D.C.; and Philadelphia, Pa. From the Department of Plastic Surgery, Georgetown University Hospital; and the Division of Plastic Surgery, Perleman School of Medicine, University of Pennsylvania. TI - Is Single-Stage Prosthetic Reconstruction Cost Effective? A Cost-Utility Analysis for the Use of Direct-to-Implant Breast Reconstruction Relative to Expander-Implant Reconstruction in Postmastectomy Patients. [Review] CM - Comment in: Plast Reconstr Surg. 2017 May;139(5):1204e-1205e; PMID: 28085717 SO - Plastic & Reconstructive Surgery. 138(3):537-47, 2016 Sep AS - Plast Reconstr Surg. 138(3):537-47, 2016 Sep NJ - Plastic and reconstructive surgery VO - 138 IP - 3 PG - 537-47 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Implantation MH - *Cost-Benefit Analysis MH - Decision Trees MH - Female MH - Humans MH - *Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Postoperative Complications MH - Quality of Life MH - Tissue Expansion Devices AB - BACKGROUND: Prosthetic breast reconstruction is most commonly performed using the two-stage (expander-implant) technique. However, with the advent of skin-sparing mastectomy and the use of acellular dermal matrices, one-stage prosthetic reconstruction has become more feasible. Prior studies have suggested that one-stage reconstruction has economic advantages relative to two-stage reconstruction despite a higher revision rate. This is the first cost-utility analysis to compare the cost and quality of life of both procedures to guide patient care. AB - METHODS: A comprehensive literature review was conducted using the MEDLINE, EMBASE, and Cochrane databases to include studies directly comparing matched patient cohorts undergoing single-stage or staged prosthetic reconstruction. Six studies were selected examining 791 direct-to-implant reconstructions and 1142 expander-implant reconstructions. Costs were derived adopting both patient and third-party payer perspectives. Utilities were derived by surveying an expert panel. Probabilities of clinically relevant complications were combined with cost and utility estimates to fit into a decision tree analysis. AB - RESULTS: The overall complication rate was 35 percent for single-stage reconstruction and 34 percent for expander-implant reconstruction. The authors' baseline analysis using Medicare reimbursement revealed a cost decrease of $525.25 and a clinical benefit of 0.89 quality-adjusted life-year when performing single-stage reconstructions, yielding a negative incremental cost-utility ratio. When using national billing, the incremental cost-utility further decreased, indicating that direct-to-implant breast reconstruction was the dominant strategy. Sensitivity analysis confirmed the robustness of the authors' conclusions. AB - CONCLUSIONS: Direct-to-implant breast reconstruction is the dominant strategy when used appropriately. Surgeons are encouraged to consider single-stage reconstruction when feasible in properly selected patients. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002428 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000002428 [doi] ID - 00006534-201609000-00001 [pii] PP - ppublish LG - English DP - 2016 Sep EZ - 2016/08/25 06:00 DA - 2017/05/18 06:00 DT - 2016/08/25 06:00 YR - 2016 ED - 20170517 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27556599 <68. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27782982 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sobti N AU - Liao EC FA - Sobti, Nikhil FA - Liao, Eric C IN - Sobti, Nikhil. Boston, Mass. From the Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital. TI - Surgeon-Controlled Study and Meta-Analysis Comparing FlexHD and AlloDerm in Immediate Breast Reconstruction Outcomes. SO - Plastic & Reconstructive Surgery. 138(5):959-967, 2016 Nov AS - Plast Reconstr Surg. 138(5):959-967, 2016 Nov NJ - Plastic and reconstructive surgery VO - 138 IP - 5 PG - 959-967 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Combined Modality Therapy MH - Female MH - Hematoma/ep [Epidemiology] MH - Hematoma/et [Etiology] MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - Prophylactic Mastectomy MH - Retrospective Studies MH - Seroma/ep [Epidemiology] MH - Seroma/et [Etiology] MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/et [Etiology] MH - Treatment Outcome MH - Wound Healing AB - BACKGROUND: The use of acellular dermal matrix has facilitated immediate prosthesis-based breast reconstruction. However, few studies directly compare surgical outcomes following acellular dermal matrix-based reconstruction with two of the most commonly available materials, AlloDerm and FlexHD. Those studies that are available often do not adequately control for the surgeon as a variable. The authors hypothesize that complication rates will not differ significantly between AlloDerm and FlexHD when practice and surgeon variables are properly controlled. AB - METHODS: Retrospective review was conducted to identify consecutive implant-based reconstruction procedures performed at a tertiary academic medical institution by a single plastic surgeon over 6 years. Univariate and binomial regression analyses were conducted to compare patient characteristics and clinical endpoints across acellular dermal matrix groups (AlloDerm/AlloDerm ready-to-use versus FlexHD Pliable/Perforated). AB - RESULTS: Of the 233 patients that underwent matrix-based breast reconstruction, 11 (4.7 percent) developed surgical-site infection. The infection rate was not statistically different between patients who received FlexHD [n = 5 (5.0 percent)] versus AlloDerm [n = 6 (4.6 percent)] on either univariate (p = 0.89) or binomial regression analysis (p = 0.56). Likewise, there were no statistical differences in rates of seroma, hematoma, explantation, or delayed wound healing. AB - CONCLUSIONS: Clinical endpoints of interest were all equivalent between acellular dermal matrix types. This study uniquely reports a single-surgeon case series comparing outcomes between different acellular dermal matrix types. Instead of focusing on acellular dermal matrix as a predictor of outcome, other patient and surgeon factors should be addressed to improve results and innovate better alternatives. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Comparative Study PT - Journal Article PT - Meta-Analysis ID - 10.1097/PRS.0000000000002616 [doi] ID - 00006534-201611000-00001 [pii] PP - ppublish LG - English DP - 2016 Nov EZ - 2016/10/27 06:00 DA - 2017/05/16 06:00 DT - 2016/10/27 06:00 YR - 2016 ED - 20170515 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27782982 <69. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27673529 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ricci JA AU - Treiser MD AU - Tao R AU - Jiang W AU - Guldbrandsen G AU - Halvorson E AU - Hergrueter CA AU - Chun YS FA - Ricci, Joseph A FA - Treiser, Matthew D FA - Tao, Ran FA - Jiang, Wei FA - Guldbrandsen, Gretchen FA - Halvorson, Eric FA - Hergrueter, Charles A FA - Chun, Yoon S IN - Ricci, Joseph A. Boston, Mass. From Harvard Plastic Surgery Residency Program, the Division of Plastic Surgery, Department of Surgery, and the Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School. TI - Predictors of Complications and Comparison of Outcomes Using SurgiMend Fetal Bovine and AlloDerm Human Cadaveric Acellular Dermal Matrices in Implant-Based Breast Reconstruction. SO - Plastic & Reconstructive Surgery. 138(4):583e-91e, 2016 Oct AS - Plast Reconstr Surg. 138(4):583e-91e, 2016 Oct NJ - Plastic and reconstructive surgery VO - 138 IP - 4 PG - 583e-91e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Animals MH - *Breast Implantation/is [Instrumentation] MH - Breast Implantation/mt [Methods] MH - Cattle MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - Logistic Models MH - Middle Aged MH - Multivariate Analysis MH - Outcome Assessment (Health Care) MH - *Postoperative Complications/et [Etiology] MH - Retrospective Studies MH - Risk Factors AB - BACKGROUND: Implant-based breast reconstruction with an acellular dermal matrix is one of the most common procedures performed by plastic surgeons. Although numerous matrices are available, there is little literature comparing them. This study compares the rates of complications between two commonly used products: AlloDerm (human cadaveric) and SurgiMend (fetal bovine) acellular dermal matrices. AB - METHODS: A retrospective review of a single center's 6-year experience was performed for consecutive, immediate breast reconstructions with acellular dermal matrix from 2009 to 2014. The authors compared demographics and surgical characteristics between patients receiving AlloDerm versus SurgiMend. Multivariate logistic regression was used to determine any association between type of matrix and surgical complications and to identify other clinical predictors for complications. AB - RESULTS: A total of 640 patients underwent 952 reconstructions using AlloDerm [578 breasts (61 percent)] or SurgiMend [374 breasts (39 percent)]. The average follow-up was 587 days. Multivariate analysis revealed that type of matrix was not an independent risk factor for the development of complications. However, smoking, age, radiotherapy, and initial tissue expander fill volume were associated with increased risk of postoperative complications. AB - CONCLUSIONS: Both AlloDerm and SurgiMend acellular dermal matrices demonstrate similar rates of major complications when used in immediate implant-based breast reconstruction. In contrast, preoperative radiation therapy, smoking, increasing age, and initial tissue expander fill volume are independent risk factors for postoperative complications. Reconstructive surgeons should take these findings into consideration when performing implant-based breast reconstruction with a dermal matrix. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002535 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0000000000002535 [doi] ID - 00006534-201610000-00006 [pii] PP - ppublish LG - English DP - 2016 Oct EZ - 2016/09/28 06:00 DA - 2017/05/06 06:00 DT - 2016/09/28 06:00 YR - 2016 ED - 20170505 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27673529 <70. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28341592 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hinchcliff KM AU - Orbay H AU - Busse BK AU - Charvet H AU - Kaur M AU - Sahar DE FA - Hinchcliff, Katharine M FA - Orbay, Hakan FA - Busse, Brittany K FA - Charvet, Heath FA - Kaur, Mankushpreet FA - Sahar, David E IN - Hinchcliff, Katharine M. University of California - Davis Medical Center, Department of Surgery, Division of Plastic Surgery, Sacramento, CA, USA. Electronic address: kmhinchcliff@ucdavis.edu. IN - Orbay, Hakan. University of California - Davis Medical Center, Department of Surgery, Division of Plastic Surgery, Sacramento, CA, USA. IN - Busse, Brittany K. University of California - Davis Medical Center, Department of Surgery, Sacramento, CA, USA. IN - Charvet, Heath. University of California - Davis Medical Center, Department of Surgery, Sacramento, CA, USA. IN - Kaur, Mankushpreet. University of California - Davis Medical Center, Department of Surgery, Division of Plastic Surgery, Sacramento, CA, USA. IN - Sahar, David E. University of California - Davis Medical Center, Department of Surgery, Division of Plastic Surgery, Sacramento, CA, USA. TI - Comparison of two cadaveric acellular dermal matrices for immediate breast reconstruction: A prospective randomized trial. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 70(5):568-576, 2017 May AS - J Plast Reconstr Aesthet Surg. 70(5):568-576, 2017 May NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 70 IP - 5 PG - 568-576 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - *Breast Implants MH - Collagen/ec [Economics] MH - Collagen/tu [Therapeutic Use] MH - Cost-Benefit Analysis MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Patient Satisfaction MH - Postoperative Complications/et [Etiology] MH - Prospective Studies MH - Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion/ed [Education] MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion Devices/ae [Adverse Effects] MH - Tissue Expansion Devices/ec [Economics] KW - *Acellular dermal matrix; *Alloderm; *Allomax; *Breast reconstruction; *Outcomes AB - AlloDerm RTU and AlloMaxTM are two acellular dermal matrices (ADMs) used in implant-based breast reconstruction. In this study, we examined whether different processing methods for the ADMs lead to a disparity in histologic, clinical, and financial outcomes after breast reconstruction. Thirty patients undergoing implant-based breast reconstruction were randomized into AlloMax or AlloDerm arms (n = 15, each). ADM was placed at the time of immediate reconstruction. Patients were evaluated for complications on postoperative days 7, 14, and 30. During implant exchange, ADM biopsies were taken and compared histologically for vascular and cellular infiltration. Patient satisfaction was evaluated using the BRECON-31 questionnaire 1 year after implant exchange. A cost analysis was performed comparing the two ADMs. Patient demographics and complication rates were similar between the two groups (p > 0.05). Histologically, vessel density and fibroblast/inflammatory cell infiltrate were greater on the dermal side than on the implant side (p < 0.01) in both ADMs, suggesting greater vascular and cellular in-growth from the dermal side. Vessel density in the middle portion of the Allomax biopsies was significantly higher than the same site in the Alloderm biopsies (p < 0.05). The extent of fibroblast/inflammatory cell infiltration was similar in both arms (p > 0.05). The BRECON-31 satisfaction questionnaire yielded similar responses across all metrics between the two study arms. The negotiated price was slightly different when comparing the two ADMs, with no significant difference in ADM reimbursement. In this study, AlloDerm RTU and AlloMax were successfully used for implant-based breast reconstruction with comparable outcomes. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (AlloMax) RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30113-4 DO - https://dx.doi.org/10.1016/j.bjps.2017.02.024 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial ID - S1748-6815(17)30113-4 [pii] ID - 10.1016/j.bjps.2017.02.024 [doi] PP - ppublish PH - 2016/09/04 [received] PH - 2017/01/23 [revised] PH - 2017/02/22 [accepted] LG - English EP - 20170306 DP - 2017 May EZ - 2017/03/28 06:00 DA - 2017/04/30 06:00 DT - 2017/03/26 06:00 YR - 2017 ED - 20170428 RD - 20170428 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=28341592 <71. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27465178 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Choi M AU - Frey JD AU - Alperovich M AU - Levine JP AU - Karp NS FA - Choi, Mihye FA - Frey, Jordan D FA - Alperovich, Michael FA - Levine, Jamie P FA - Karp, Nolan S IN - Choi, Mihye. New York, N.Y. From the Hansjorg Wyss Department of Plastic Surgery, New York University Langone Medical Center. TI - "Breast in a Day": Examining Single-Stage Immediate, Permanent Implant Reconstruction in Nipple-Sparing Mastectomy. SO - Plastic & Reconstructive Surgery. 138(2):184e-91e, 2016 Aug AS - Plast Reconstr Surg. 138(2):184e-91e, 2016 Aug NJ - Plastic and reconstructive surgery VO - 138 IP - 2 PG - 184e-91e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - *Nipples/su [Surgery] MH - Retrospective Studies MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Nipple-sparing mastectomy with immediate, permanent implant reconstruction offers patients a prosthetic "breast in a day" compared to tissue expander techniques requiring multiple procedures. AB - METHODS: Patients undergoing nipple-sparing mastectomy with immediate, permanent implant reconstruction were reviewed with patient demographics and outcomes analyzed. AB - RESULTS: Of 842 nipple-sparing mastectomies from 2006 to June of 2015, 160 (19.0 percent) underwent immediate, permanent implant reconstruction. The average age and body mass index were 46.5 years and 23.3 kg/m. The majority of implants were either Allergan Style 20 (48.1 percent) or Style 15 (22.5 percent). The average implant size was 376.2 ml, and 91.3 percent of reconstructions used acellular dermal matrix. The average number of reconstructive operations was 1.3. Follow-up was 21.9 months. The most common major complication was major mastectomy flap necrosis (8.1 percent). The rate of reconstructive failure was 5.6 percent and implant loss was 4.4 percent. The most common minor complication was minor mastectomy flap necrosis (14.4 percent). The rates of full-thickness and partial-thickness nipple necrosis were 4.4 and 7.5 percent, respectively. Age older than 50 years (p = 0.0276) and implant size greater than 400 ml (p = 0.0467) emerged as independent predictors of overall complications. Obesity (p = 0.4073), tobacco use (p = 0.2749), prior radiation therapy (p = 0.4613), and acellular dermal matrix (p = 0.5305) were not associated with greater complication rates. AB - CONCLUSION: Immediate, permanent implant reconstruction in nipple-sparing mastectomy provides patients with a breast in a day in less than two procedures, with a low complication rate. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002333 PT - Journal Article ID - 10.1097/PRS.0000000000002333 [doi] ID - 00006534-201608000-00004 [pii] PP - ppublish LG - English DP - 2016 Aug EZ - 2016/07/29 06:00 DA - 2017/04/26 06:00 DT - 2016/07/29 06:00 YR - 2016 ED - 20170425 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27465178 <72. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27465177 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Qureshi AA AU - Broderick KP AU - Belz J AU - Funk S AU - Reaven N AU - Brandt KE AU - Tenenbaum MM AU - Margenthaler JA AU - Aft RL AU - Myckatyn TM FA - Qureshi, Ali A FA - Broderick, Kristen P FA - Belz, Jessica FA - Funk, Susan FA - Reaven, Nancy FA - Brandt, Keith E FA - Tenenbaum, Marissa M FA - Margenthaler, Julie A FA - Aft, Rebecca L FA - Myckatyn, Terence M IN - Qureshi, Ali A. St. Louis, Mo.; and La Canada, Calif. From the Division of Plastic and Reconstructive Surgery and the Department of Surgery, Washington University School of Medicine; and Strategic Health Resources. TI - Uneventful versus Successful Reconstruction and Outcome Pathways in Implant-Based Breast Reconstruction with Acellular Dermal Matrices. SO - Plastic & Reconstructive Surgery. 138(2):173e-83e, 2016 Aug AS - Plast Reconstr Surg. 138(2):173e-83e, 2016 Aug NJ - Plastic and reconstructive surgery VO - 138 IP - 2 PG - 173e-83e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Patient Satisfaction MH - Retrospective Studies MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Meaningful data to help guide resource allocation for staged tissue expander/implant-based breast reconstruction are currently lacking. The authors seek to differentiate uneventful from successful reconstruction and identify common outcome pathways and factors that portend a deviation from an uneventful, two-stage, two-operation course. AB - METHODS: A retrospective analysis of expander/implant reconstructions with or without acellular dermal matrix (2003 to 2009) was performed. Related postreconstructive events (including mastectomy flap necrosis, seroma, wound dehiscence, cellulitis, explantation, hematoma, and capsular revisions) were assessed for 2 years. Uneventful reconstruction was defined as exchange to breast implant within 2 years of tissue expander placement without complications, whereas successful reconstruction was defined as exchange to breast implant within 2 years with or without complications. Factors affecting reconstructive success were analyzed, and patterns of postreconstructive events were summarized as outcome pathways. AB - RESULTS: Four hundred thirteen patients (295 with acellular dermal matrix and 118 without), with 602 breasts (432 with acellular dermal matrix and 170 without) underwent reconstruction. Forty-six percent of patients (48 percent with acellular dermal matrix and 40 percent without), experienced uneventful reconstruction. Reconstructive success was achieved in 337 patients (82 percent; 82.0 percent with acellular dermal matrix and 80.5 percent without), with reconstructive failure occurring in 58 patients. Multiple logistic regression analyses determined that cellulitis, seroma, and skin necrosis (OR, 15.8, 7.7, and 8.4, respectively) were highly predictive of reconstructive failure. The authors identified 10 distinct pathways experienced by tissue expander/implant patients that were characterized by specific postreconstructive events. AB - CONCLUSION: The present study will facilitate discussions among patients, providers, and payers by providing a framework for understanding the myriad outcome pathways in implant-based reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002402 PT - Journal Article ID - 10.1097/PRS.0000000000002402 [doi] ID - 00006534-201608000-00003 [pii] PP - ppublish LG - English DP - 2016 Aug EZ - 2016/07/29 06:00 DA - 2017/04/26 06:00 DT - 2016/07/29 06:00 YR - 2016 ED - 20170425 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27465177 <73. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27351472 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Liao EC FA - Liao, Eric C IN - Liao, Eric C. Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass. TI - Different Acellular Dermal Matrix Preparations, Different Surgeons, Different Outcomes: What Factors Matter?. CM - Comment in: Plast Reconstr Surg. 2016 Jul;138(1):146e-7e; PMID: 27348677 SO - Plastic & Reconstructive Surgery. 138(1):145e-6e, 2016 Jul AS - Plast Reconstr Surg. 138(1):145e-6e, 2016 Jul NJ - Plastic and reconstructive surgery VO - 138 IP - 1 PG - 145e-6e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Clinical Competence MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Surgeons/st [Standards] MH - Treatment Outcome ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002273 PT - Letter ID - 10.1097/PRS.0000000000002273 [doi] ID - 00006534-201607000-00063 [pii] PP - ppublish LG - English DP - 2016 Jul EZ - 2016/06/29 06:00 DA - 2017/04/26 06:00 DT - 2016/06/29 06:00 YR - 2016 ED - 20170425 RD - 20171025 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27351472 <74. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27064232 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA AU - Ashikari AY AU - Berry C AU - Hunsicker LM FA - Salzberg, C Andrew FA - Ashikari, Andrew Y FA - Berry, Colleen FA - Hunsicker, Lisa M IN - Salzberg, C Andrew. New York, N.Y.; and Littleton, Colo. From the Icahn School of Medicine, Mount Sinai Health Systems; the Ashikari Breast Center; and Revalla Plastic Surgery & Medical Aesthetics. TI - Acellular Dermal Matrix-Assisted Direct-to-Implant Breast Reconstruction and Capsular Contracture: A 13-Year Experience. CM - Comment in: Plast Reconstr Surg. 2016 Aug;138(2):338-9; PMID: 27465157 CM - Comment in: Plast Reconstr Surg. 2017 Apr;139(4):1014e-1015e; PMID: 28002277 SO - Plastic & Reconstructive Surgery. 138(2):329-37, 2016 Aug AS - Plast Reconstr Surg. 138(2):329-37, 2016 Aug NJ - Plastic and reconstructive surgery VO - 138 IP - 2 PG - 329-37 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Female MH - Follow-Up Studies MH - *Forecasting MH - Humans MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Retrospective Studies MH - Young Adult AB - BACKGROUND: Use of acellular dermal matrix for implant-based breast reconstruction appears to be associated with a lower incidence of capsular contracture compared with standard reconstruction. The majority of acellular dermal matrix studies were, however, of short duration; thus, long-term incidence of capsular contracture with acellular dermal matrix use is unknown. AB - METHODS: Patients undergoing acellular dermal matrix-assisted breast reconstruction from December of 2001 to May of 2014 at two institutions were evaluated. Cumulative incidence of capsular contracture was determined by the performing surgeon. A retrospective chart review was performed on prospectively gathered data on patient-, breast-, surgery-, and implant-related characteristics that were analyzed as potential risk factors for the development of capsular contracture. AB - RESULTS: A total of 1584 breast reconstructions in 863 patients were performed. Mean follow-up of patients was 4.7 years; 45 percent of patients had greater than or equal to 5 years of follow-up. The cumulative incidence of capsular contracture was 0.8 percent. Smaller implant size (<400 ml) and postoperative radiotherapy were significantly associated with an increased risk of capsular contracture, but the incidence of capsular contracture was 1.9 percent in irradiated breasts. All capsular contractures developed within the first 2 years, with no new events with longer follow-up. AB - CONCLUSIONS: In this long-term study, the cumulative incidence of capsular contracture with acellular dermal matrix-assisted reconstruction remains low, even in irradiated breasts. Capsular contracture appears to be an early event, and longer follow-up does not appear to increase the incidence, suggesting that acellular dermal matrix may truly mitigate the development of capsular contracture as opposed to delaying its occurrence. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002331 PT - Journal Article ID - 10.1097/PRS.0000000000002331 [doi] PP - ppublish LG - English DP - 2016 Aug EZ - 2016/04/12 06:00 DA - 2017/04/26 06:00 DT - 2016/04/12 06:00 YR - 2016 ED - 20170425 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27064232 <75. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27424788 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Potter S AU - Holcombe C AU - Blazeby J AU - iBRA Research Collaborative FA - Potter, S FA - Holcombe, C FA - Blazeby, J FA - iBRA Research Collaborative IN - Potter, S. Bristol Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Canynge Hall, UK. Electronic address: shelley.potter@bristol.ac.uk. IN - Holcombe, C. Linda McCartney Centre, Royal Liverpool and Broadgreen University Hospital, Prescot Street, Liverpool, L7 8XP, UK. IN - Blazeby, J. Bristol Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Canynge Hall, UK. TI - Response to: Gschwantler-Kaulich et al (2016) Mesh versus acellular dermal matrix in immediate implant-based breast reconstruction - A prospective randomized trial doi:10.1016/j.ejso.2016.02.007. CM - Comment on: Eur J Surg Oncol. 2016 May;42(5):665-71; PMID: 26947961 SO - European Journal of Surgical Oncology. 42(11):1767-1768, 2016 11 AS - Eur J Surg Oncol. 42(11):1767-1768, 2016 11 NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 42 IP - 11 PG - 1767-1768 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis MH - *Breast Implantation MH - Breast Implants MH - Humans MH - Mammaplasty MH - Mastectomy MH - Prospective Studies ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(16)30593-5 DO - https://dx.doi.org/10.1016/j.ejso.2016.05.041 PT - Letter PT - Comment ID - S0748-7983(16)30593-5 [pii] ID - 10.1016/j.ejso.2016.05.041 [doi] PP - ppublish PH - 2016/05/01 [received] PH - 2016/05/04 [accepted] GI - No: PB-PG-0214-33065 Organization: *Department of Health* Country: United Kingdom LG - English EP - 20160624 DP - 2016 11 EZ - 2016/10/22 06:00 DA - 2017/04/22 06:00 DT - 2016/07/19 06:00 YR - 2016 ED - 20170421 RD - 20170922 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27424788 <76. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27219249 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL FA - Spear, Scott L IN - Spear, Scott L. Washington, D.C. From the Department of Plastic Surgery, Georgetown University Medical Center. TI - Underpromise. CM - Comment in: Plast Reconstr Surg. 2017 Mar;139(3):793e-794e; PMID: 28234866 SO - Plastic & Reconstructive Surgery. 137(6):1961-2, 2016 Jun AS - Plast Reconstr Surg. 137(6):1961-2, 2016 Jun NJ - Plastic and reconstructive surgery VO - 137 IP - 6 PG - 1961-2 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis/px [Psychology] MH - *Acellular Dermis MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty MH - *Mastectomy MH - Patient Education as Topic MH - *Patient Satisfaction MH - *Postoperative Complications/px [Psychology] MH - *Surgical Flaps ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002145 PT - Journal Article ID - 10.1097/PRS.0000000000002145 [doi] ID - 00006534-201606000-00054 [pii] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/05/25 06:00 DA - 2017/04/19 06:00 DT - 2016/05/25 06:00 YR - 2016 ED - 20170418 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27219249 <77. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27219260 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Baldelli I AU - Cardoni G AU - Franchelli S AU - Fregatti P AU - Friedman D AU - Pesce M AU - Ponte E AU - Santori G AU - Santi P FA - Baldelli, Ilaria FA - Cardoni, Gaia FA - Franchelli, Simonetta FA - Fregatti, Piero FA - Friedman, Daniele FA - Pesce, Marianna FA - Ponte, Erica FA - Santori, Gregorio FA - Santi, Pierluigi IN - Baldelli, Ilaria. Genoa, Italy From the Department of Surgical Sciences and Integrated Diagnostics, University of Genoa; and the Plastic Surgery Department, IRCCS San Martino University Hospital, National Institute for Cancer Research. TI - Implant-Based Breast Reconstruction Using a Polyester Mesh (Surgimesh-PET): A Retrospective Single-Center Study. SO - Plastic & Reconstructive Surgery. 137(6):931e-9e, 2016 Jun AS - Plast Reconstr Surg. 137(6):931e-9e, 2016 Jun NJ - Plastic and reconstructive surgery VO - 137 IP - 6 PG - 931e-9e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Breast Implants MH - Case-Control Studies MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Neoadjuvant Therapy MH - *Polyesters MH - *Postoperative Complications/et [Etiology] MH - *Postoperative Complications/su [Surgery] MH - Radiotherapy, Adjuvant MH - Reoperation MH - Retrospective Studies MH - Risk Factors MH - *Surgical Mesh AB - BACKGROUND: Although the introduction of acellular dermal matrices is considered one of the most important advancements in alloplastic breast reconstruction, costs and local policy limit their use in Italy. The purpose of this study was to assess short-term outcomes following Surgimesh-PET-based breast reconstruction. AB - METHODS: A single-center, retrospective, case-control study was performed from January 1, 2012, to December 31, 2013, by enrolling 206 breast reconstructions performed in 196 patients after oncologic (n = 200) or prophylactic (n = 6) mastectomy. Group A included 63 patients who underwent 70 immediate Surgimesh-PET-assisted breast reconstructions, and group B included 133 patients who underwent 136 standard breast reconstructions. AB - RESULTS: No significant differences between groups occurred for early postoperative complications (p = 0.610), major complications that required surgical revision (p = 0.887), volume (p = 0.498) or width of the prosthesis (p = 0.201), skin-sparing mastectomy (p = 0.315), or axillary surgery (p = 0.265). Multivariate logistic regression showed that prior radiotherapy was the only significant variable for early postoperative complications in both whole series (p = 0.011) and group B (p = 0.046), whereas body mass index greater than 25 was an independent predictor in group A (p = 0.041). Prior radiotherapy was the only variable that reached statistical significance in the multivariate model for major complications in the whole series (p = 0.005). AB - CONCLUSIONS: Short-term outcomes of Surgimesh-PET-based alloplastic breast reconstruction are promising. Further studies are needed to evaluate the long-term results of this surgical approach. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Polyesters) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002180 PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article ID - 10.1097/PRS.0000000000002180 [doi] ID - 00006534-201606000-00008 [pii] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/05/25 06:00 DA - 2017/04/18 06:00 DT - 2016/05/25 06:00 YR - 2016 ED - 20170417 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27219260 <78. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27219226 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Caputo GG AU - Marchetti A AU - Dalla Pozza E AU - Vigato E AU - Domenici L AU - Cigna E AU - Governa M FA - Caputo, Glenda Giorgia FA - Marchetti, Alberto FA - Dalla Pozza, Edoardo FA - Vigato, Enrico FA - Domenici, Lavinia FA - Cigna, Emanuele FA - Governa, Maurizio IN - Caputo, Glenda Giorgia. Verona and Rome, Italy From the Department of Plastic and Reconstructive Surgery, Azienda Ospedaliera Universitaria Integrata; and the Department of Surgery, "Sapienza" University of Rome. TI - Skin-Reduction Breast Reconstructions with Prepectoral Implant. SO - Plastic & Reconstructive Surgery. 137(6):1702-5, 2016 Jun AS - Plast Reconstr Surg. 137(6):1702-5, 2016 Jun NJ - Plastic and reconstructive surgery VO - 137 IP - 6 PG - 1702-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Nipples/su [Surgery] MH - *Pectoralis Muscles/tr [Transplantation] MH - Retrospective Studies MH - *Surgical Flaps MH - Time Factors MH - Treatment Outcome AB - UNLABELLED: Skin-reduction mastectomy with prepectoral implant reconstruction is a novel technique for immediate breast reconstruction, with subcutaneous implant placement in patients eligible for skin-reducing mastectomy. Implants were placed above the pectoralis muscles in a compound pocket made by a dermal flap and acellular dermal matrix. The procedure was performed on 33 breasts in 27 selected patients. In three cases, there was skin ischemia; in one case, it healed spontaneously; and in two patients, a surgical necrosectomy and primary closure were needed. No implant loss occurred. This new technique proved to be a useful alternative, with good cosmetic results, in selected patients requiring mastectomy. These preliminary results need to be confirmed by long-term and comparative studies. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002227 PT - Journal Article ID - 10.1097/PRS.0000000000002227 [doi] ID - 00006534-201606000-00009 [pii] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/05/25 06:00 DA - 2017/04/14 06:00 DT - 2016/05/25 06:00 YR - 2016 ED - 20170413 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27219226 <79. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27219225 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Clarke-Pearson EM AU - Lin AM AU - Hertl C AU - Austen WG AU - Colwell AS FA - Clarke-Pearson, Emily M FA - Lin, Alex M FA - Hertl, Catherine FA - Austen, William G FA - Colwell, Amy S IN - Clarke-Pearson, Emily M. Boston, Mass. From the Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School. TI - Revisions in Implant-Based Breast Reconstruction: How Does Direct-to-Implant Measure Up?. SO - Plastic & Reconstructive Surgery. 137(6):1690-9, 2016 Jun AS - Plast Reconstr Surg. 137(6):1690-9, 2016 Jun NJ - Plastic and reconstructive surgery VO - 137 IP - 6 PG - 1690-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - Aged, 80 and over MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Reoperation MH - Retrospective Studies MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Immediate direct-to-implant breast reconstruction is increasingly performed for breast cancer treatment or prevention. The advantage over traditional tissue expander/implant reconstruction includes the potential for fewer surgical procedures. AB - METHODS: Retrospective, single-institution, three-surgeon review identified patients undergoing implant-based reconstruction from 2006 to 2011. AB - RESULTS: Six hundred eighty-two reconstructions were performed in 432 women with an average follow-up of 5 years. Four hundred sixty-five were direct-to-implant reconstructions with acellular dermal matrix while 217 were tissue expander/implant reconstructions without acellular dermal matrix. The overall revision rate in direct-to-implant reconstruction was 20.9 percent. There was no difference in total revision rates between direct-to-implant and tissue expander reconstruction (20.9 percent versus 20.3 percent; p = 0.861). Subgroup analysis showed no difference in revision for malposition (3.4 percent versus 5.5 percent; p = 0.200), size change (6.7 percent versus 5.5 percent; p = 0.569), fat grafting (8.6 percent versus 9.7 percent; p = 0.647), or capsular contracture (4.5 percent versus 3.2 percent; p = 0.429). Multivariable logistic regression analysis showed complications were associated with higher rates of revision for malposition or size in both groups (OR, 2.8; 95 percent CI, 1.56 to 5.13; p = 0.001). Smoking, preoperative irradiation, skin necrosis, and one surgeon were associated with higher rates of fat grafting, whereas increasing body mass index was associated with lower rates. Postoperative radiotherapy and hematoma were predictive of revision for capsular contracture. AB - CONCLUSIONS: The 5-year revision rate in this series of direct-to-implant reconstruction was approximately 21 percent and similar to the revision rate in tissue expander/implant reconstruction. Surgical complications, radiotherapy, and the surgeon influenced the rate of revision similarly in both groups. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000002173 PT - Journal Article ID - 10.1097/PRS.0000000000002173 [doi] ID - 00006534-201606000-00006 [pii] PP - ppublish LG - English DP - 2016 Jun EZ - 2016/05/25 06:00 DA - 2017/04/14 06:00 DT - 2016/05/25 06:00 YR - 2016 ED - 20170413 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27219225 <80. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27312036 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Headon H AU - Kasem A AU - Manson A AU - Choy C AU - Carmichael AR AU - Mokbel K FA - Headon, Hannah FA - Kasem, Abdul FA - Manson, Aisling FA - Choy, Christina FA - Carmichael, Amtul R FA - Mokbel, Kefah IN - Headon, Hannah. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, United Kingdom. IN - Kasem, Abdul. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, United Kingdom. IN - Manson, Aisling. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, United Kingdom. IN - Choy, Christina. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, United Kingdom. IN - Carmichael, Amtul R. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, United Kingdom. IN - Mokbel, Kefah. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, United Kingdom. Electronic address: kefahmokbel@hotmail.com. TI - Clinical outcome and patient satisfaction with the use of bovine-derived acellular dermal matrix (SurgiMendTM) in implant based immediate reconstruction following skin sparing mastectomy: A prospective observational study in a single centre. SO - Surgical Oncology. 25(2):104-10, 2016 Jun AS - Surg Oncol. 25(2):104-10, 2016 Jun NJ - Surgical oncology VO - 25 IP - 2 PG - 104-10 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - byv, 9208188 IO - Surg Oncol SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Animals MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/pa [Pathology] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - Carcinoma, Intraductal, Noninfiltrating/pa [Pathology] MH - *Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - Cattle MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty MH - *Mastectomy MH - Middle Aged MH - Neoplasm Recurrence, Local/pa [Pathology] MH - *Neoplasm Recurrence, Local/su [Surgery] MH - Neoplasm Staging MH - *Organ Sparing Treatments MH - Patient Satisfaction MH - Prognosis MH - Prospective Studies MH - Quality of Life KW - *Acellular dermal matrix; *Breast cancer; *Reconstructive surgery AB - INTRODUCTION: The advent of acellular dermal matrix devices (ADMs) has enhanced both the scope of implant-based immediate breast reconstruction (IBR) following skin sparing mastectomy (SSM) for the treatment or risk reduction of breast cancer. Currently, there are a wide range of options available for the use of ADMs. AB - METHODS: This is a prospective observational single institution study of 118 consecutive patients undergoing a total of 164 SSM and IBR procedures either for treatment for breast cancer or for risk reduction, between 2012 and 2014. IBR was performed using an implant and bovine-derived ADM (SurgiMendTM). Nipple sparing mastectomy (NSM) accounted for 103 procedures. IBR was performed as a single stage procedure in 23% of patients. The primary endpoint of this prospective study was the explantation rate and secondary endpoints included quality of life, patient satisfaction, aesthetic outcome assessed objectively, surgical complications, overall and disease free survival. AB - RESULTS: Forty-six patients (39%) had a bilateral and 72 underwent a unilateral SSM. Of those who underwent a unilateral SSM, 25 had a contralateral adjustment procedure. Out of 164 procedures, 117 (71%) were for the treatment of breast cancer. Sixty-one patients received chemotherapy (52%) and 32 (27%) had radiotherapy. In this study 27 patients underwent post-mastectomy radiotherapy. At a mean follow of 21 months, the explantation rate was 1.2%, 4% (6 patients) developed wound complications. The patient satisfaction with the procedure was found to be very high. The mean Breast Q Score was 85 and the mean overall patient satisfaction rating was 9 out of a possible 10. The mean objective assessment score was 8.9 out of a possible 10 and the mean subjective capsular contracture severity score was 2.9 out of 10. There were two cases of local recurrence (1.7%), one distant recurrence (0.8%) and one patient died of metastatic breast cancer (0.8%). Overall survival was 99.2% and locoregional disease free survival (LRFS) was 98.3%. One patient (0.8%) developed a mild inflammatory reaction secondary to the underlying mesh. AB - CONCLUSIONS: SurgiMendTM is an effective adjunct to implant based IBR following SSM. It is associated with a very low rate of implant loss and a high level of patient satisfaction and is associated with a very low incidence of inflammatory reaction. Neither prior radiotherapy nor post-mastectomy radiotherapy (PMRT) represents a contraindication to its use. Copyright © 2016 Elsevier Ltd. All rights reserved. ES - 1879-3320 IL - 0960-7404 DI - S0960-7404(16)30004-4 DO - https://dx.doi.org/10.1016/j.suronc.2016.03.004 PT - Clinical Trial PT - Journal Article PT - Observational Study ID - S0960-7404(16)30004-4 [pii] ID - 10.1016/j.suronc.2016.03.004 [doi] PP - ppublish PH - 2015/07/21 [received] PH - 2016/01/02 [revised] PH - 2016/03/14 [accepted] LG - English EP - 20160317 DP - 2016 Jun EZ - 2016/06/18 06:00 DA - 2017/04/12 06:00 DT - 2016/06/18 06:00 YR - 2016 ED - 20170411 RD - 20170411 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27312036 <81. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27508508 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Youssef MM AU - Pucher PH AU - Kennedy K AU - Osborne C AU - Graja T AI - Youssef, Mina M G; ORCID: http://orcid.org/0000-0002-6807-313X FA - Youssef, Mina M G FA - Pucher, Philip H FA - Kennedy, Katy FA - Osborne, Caroline FA - Graja, Tomasz IN - Youssef, Mina M G. Department of Surgery, Dorset County Hospital, Dorset, UK. IN - Youssef, Mina M G. National Cancer Institute, Cairo University, Cairo, Egypt. IN - Pucher, Philip H. Department of Surgery, Dorset County Hospital, Dorset, UK. IN - Kennedy, Katy. Department of Surgery, Dorset County Hospital, Dorset, UK. IN - Osborne, Caroline. Department of Surgery, Dorset County Hospital, Dorset, UK. IN - Osborne, Caroline. Department of Surgery, Yeovil District Hospital, Somerset, UK. IN - Graja, Tomasz. Department of Surgery, Dorset County Hospital, Dorset, UK. TI - Use of Acellular Dermal Matrix versus Latissimus Dorsi Flap for Breast Reconstruction: Clinical and Patient-Reported Outcomes. SO - Breast Journal. 22(6):702-704, 2016 Nov AS - Breast J. 22(6):702-704, 2016 Nov NJ - The breast journal VO - 22 IP - 6 PG - 702-704 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Female MH - Humans MH - Length of Stay MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Patient Satisfaction MH - Postoperative Complications/et [Etiology] MH - *Superficial Back Muscles/su [Surgery] MH - *Surgical Flaps MH - Treatment Outcome ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12664 PT - Clinical Trial PT - Letter ID - 10.1111/tbj.12664 [doi] PP - ppublish LG - English EP - 20160810 DP - 2016 Nov EZ - 2016/08/11 06:00 DA - 2017/02/22 06:00 DT - 2016/08/11 06:00 YR - 2016 ED - 20170221 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27508508 <82. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26919072 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University, Washington, District of Columbia. TI - Implant-based breast reconstruction: Strategies to achieve optimal outcomes and minimize complications. [Review] SO - Journal of Surgical Oncology. 113(8):895-905, 2016 Jun AS - J Surg Oncol. 113(8):895-905, 2016 Jun NJ - Journal of surgical oncology VO - 113 IP - 8 PG - 895-905 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - k79, 0222643 IO - J Surg Oncol SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adipose Tissue/tr [Transplantation] MH - Autografts MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Patient Selection MH - Postoperative Complications/pc [Prevention & Control] MH - Treatment Outcome KW - breast implants; breast reconstruction; complications; patient selection; radiation therapy; tissue expanders AB - Breast reconstruction using prosthetic devices is the most commonly performed procedure in women following mastectomy. The goal is to provide an outcome that is predictable and reproducible while minimizing complications and optimizing aesthetics. There are various strategies by which this can be achieved. It begins with proper patient selection because most adverse events occur in high-risk patients. This in turn is related to the timing of the reconstruction that can be performed immediately following the mastectomy or on a delayed basis. Many surgeons have been combining the use of acellular dermal matrices with prosthetic devices that require strict attention to detail to ensure success. There are various options for achieving device coverage that include total muscle, partial muscle, and subcutaneous coverage. The radiated patient poses additional challenges and limitations that must be understood to achieve a desired outcome. Finally, autologous fat grafting has become a valuable tool to improve outcomes in both radiated and non-radiated women. These factors will be reviewed with the intent of improving outcomes and minimizing complications in the setting of prosthetic breast reconstruction. J. Surg. Oncol. 2016;113:895-905. © 2016 Wiley Periodicals, Inc. Copyright © 2016 Wiley Periodicals, Inc. ES - 1096-9098 IL - 0022-4790 DO - https://dx.doi.org/10.1002/jso.24210 PT - Journal Article PT - Review ID - 10.1002/jso.24210 [doi] PP - ppublish PH - 2016/02/07 [received] PH - 2016/02/09 [accepted] LG - English EP - 20160226 DP - 2016 Jun EZ - 2016/02/27 06:00 DA - 2017/02/22 06:00 DT - 2016/02/27 06:00 YR - 2016 ED - 20170221 RD - 20170221 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26919072 <83. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27697888 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nilsen TJ AU - Dasgupta A AU - Huang YC AU - Wilson H AU - Chnari E FA - Nilsen, Todd J FA - Dasgupta, Anouska FA - Huang, Yen-Chen FA - Wilson, Henry FA - Chnari, Evangelia IN - Nilsen, Todd J. Mr Nilsen is a Senior Engineer, Dr Dasgupta is a Senior Scientist, and Dr Chnari is an Associate Director, Research and Development, Wound Care, and General and Plastic Surgery; and Dr Huang is a Staff Scientist, Research and Development and Allograft Materials Research, Musculoskeletal Transplant Foundation, Edison, NJ. Dr Wilson is a Clinical Assistant Professor of Plastic Surgery, Liberty University College of Osteopathic Medicine, Lynchburg, VA. IN - Dasgupta, Anouska. Mr Nilsen is a Senior Engineer, Dr Dasgupta is a Senior Scientist, and Dr Chnari is an Associate Director, Research and Development, Wound Care, and General and Plastic Surgery; and Dr Huang is a Staff Scientist, Research and Development and Allograft Materials Research, Musculoskeletal Transplant Foundation, Edison, NJ. Dr Wilson is a Clinical Assistant Professor of Plastic Surgery, Liberty University College of Osteopathic Medicine, Lynchburg, VA. IN - Huang, Yen-Chen. Mr Nilsen is a Senior Engineer, Dr Dasgupta is a Senior Scientist, and Dr Chnari is an Associate Director, Research and Development, Wound Care, and General and Plastic Surgery; and Dr Huang is a Staff Scientist, Research and Development and Allograft Materials Research, Musculoskeletal Transplant Foundation, Edison, NJ. Dr Wilson is a Clinical Assistant Professor of Plastic Surgery, Liberty University College of Osteopathic Medicine, Lynchburg, VA. IN - Wilson, Henry. Mr Nilsen is a Senior Engineer, Dr Dasgupta is a Senior Scientist, and Dr Chnari is an Associate Director, Research and Development, Wound Care, and General and Plastic Surgery; and Dr Huang is a Staff Scientist, Research and Development and Allograft Materials Research, Musculoskeletal Transplant Foundation, Edison, NJ. Dr Wilson is a Clinical Assistant Professor of Plastic Surgery, Liberty University College of Osteopathic Medicine, Lynchburg, VA. IN - Chnari, Evangelia. Mr Nilsen is a Senior Engineer, Dr Dasgupta is a Senior Scientist, and Dr Chnari is an Associate Director, Research and Development, Wound Care, and General and Plastic Surgery; and Dr Huang is a Staff Scientist, Research and Development and Allograft Materials Research, Musculoskeletal Transplant Foundation, Edison, NJ. Dr Wilson is a Clinical Assistant Professor of Plastic Surgery, Liberty University College of Osteopathic Medicine, Lynchburg, VA. TI - Do Processing Methods Make a Difference in Acellular Dermal Matrix Properties?. SO - Aesthetic Surgery Journal. 36(suppl 2):S7-S22, 2016 Nov AS - Aesthet. surg. j.. 36(suppl 2):S7-S22, 2016 Nov NJ - Aesthetic surgery journal VO - 36 IP - suppl 2 PG - S7-S22 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - *Acellular Dermis MH - Biomechanical Phenomena MH - Cell Proliferation MH - Cells, Cultured MH - *Collagen MH - Decontamination MH - Fibroblasts/ph [Physiology] MH - Humans MH - Mammaplasty/mt [Methods] MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Sterilization AB - BACKGROUND: The use of acellular dermal matrices (ADMs) has become the standard of practice in many reconstructive and aesthetic surgical applications. Different methods used to prepare the allograft tissue for surgical use can alter the ADMs natural properties. Aseptic processing has been shown to retain the natural properties of ADMs more favorably than terminally sterilized ADMs. Terminal sterilization has been historically linked to alteration of biological materials. In vitro work was conducted to compare ADM processing methods. AB - OBJECTIVES: Characterize aseptically processed ADMs and compare cell-matrix interaction characteristics to terminally sterilized ADMs. AB - METHODS: Two aseptically processed ADMs, FlexHD Pliable and BellaDerm, were characterized via histological evaluation, biomechanical integrity, enzymatic degradation, and in vitro cell studies. FlexHD Pliable was compared to Alloderm Ready-to-Use (RTU). AB - RESULTS: Histological evaluation revealed that FlexHD Pliable had a uniform, open structure compared to BellaDerm. Mechanical characterization demonstrated that BellaDerm had higher strength and stiffness compared to FlexHD Pliable, which maintained higher elasticity. Immunohistochemical analysis verified that key matrix proteins remained intact after aseptic processing. Cell studies found that fibroblasts attached more readily, and proliferated faster on FlexHD Pliable compared to BellaDerm. Additionally, fibroblasts infiltrated into FlexHD Pliable from both sides and on the dermal side in BellaDerm and produced an abundance of multi-layered matrix proteins (collagen, fibronectin) when compared to AlloDerm RTU which was sparse. AB - CONCLUSIONS: Aseptically processed FlexHD Pliable and BellaDerm provide a suitable, biocompatible option for tissue repair and regeneration in aesthetic and reconstructive surgical applications. Copyright © 2016 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com. RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X PT - Journal Article ID - sjw163 [pii] ID - 10.1093/asj/sjw163 [doi] PP - ppublish PH - 2016/08/05 [accepted] LG - English EP - 20161003 DP - 2016 Nov EZ - 2016/10/21 06:00 DA - 2017/02/18 06:00 DT - 2016/10/05 06:00 YR - 2016 ED - 20170217 RD - 20170817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27697888 <84. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27142826 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Naseem S AU - Patel AD AU - Devalia H FA - Naseem, S FA - Patel, A D FA - Devalia, H TI - Pioneering technique using Acellular Dermal Matrix in the rescue of a radiation ulcer. SO - Giornale di Chirurgia. 37(1):46-8, 2016 Jan-Feb AS - G Chir. 37(1):46-8, 2016 Jan-Feb NJ - Il Giornale di chirurgia VO - 37 IP - 1 PG - 46-8 PI - Journal available in: Print PI - Citation processed from: Print JC - avi, 9011768 IO - G Chir PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859776 SB - Index Medicus CP - Italy MH - *Acellular Dermis MH - Adenocarcinoma, Mucinous/su [Surgery] MH - Adult MH - Antineoplastic Agents, Hormonal/tu [Therapeutic Use] MH - Breast Implantation MH - Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/dt [Drug Therapy] MH - Carcinoma, Ductal, Breast/rt [Radiotherapy] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - Combined Modality Therapy MH - Device Removal MH - Esthetics MH - Female MH - Humans MH - Mammaplasty MH - Mastectomy MH - Radiodermatitis/et [Etiology] MH - *Radiodermatitis/su [Surgery] MH - *Radiotherapy, Adjuvant/ae [Adverse Effects] MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Skin Ulcer/et [Etiology] MH - *Skin Ulcer/su [Surgery] MH - Tamoxifen/tu [Therapeutic Use] MH - Tissue Expansion Devices AB - BACKGROUND: Radiotherapy as an adjuvant to mastectomy is integral to the treatment of breast cancer, but can result in skin ulceration. Skin ulceration following radiotherapy is traditionally managed by removing the implant and allowing the skin to heal by secondary intention. AB - CASE REPORT: A 42-year-old woman underwent radiotherapy following a breast reconstruction. She developed a 2 x 3cm radiation ulcer. The ulcer was managed by removing the implant and performing capsulectomy. A Beckers 50 expander was placed and reinforced with acellular dermal matrix inferolaterally. At follow-up the patient had a good cosmetic outcome. AB - CONCLUSION: Post-radiation skin ulcers present a challenge to treat with no current standardised management. The use of acellular dermal matrix may present a new technique to promote healing in these testing cases. RN - 0 (Antineoplastic Agents, Hormonal) RN - 094ZI81Y45 (Tamoxifen) IS - 0391-9005 IL - 0391-9005 PT - Journal Article ID - 7504 [pii] ID - PMC4859776 [pmc] PP - ppublish LG - English DP - 2016 Jan-Feb EZ - 2016/05/05 06:00 DA - 2017/01/25 06:00 DT - 2016/05/05 06:00 YR - 2016 ED - 20170124 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27142826 <85. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27070347 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Yu D AU - Hanna KR AU - LeGallo RD AU - Drake DB FA - Yu, Deborah FA - Hanna, Kasandra R FA - LeGallo, Robin D FA - Drake, David B IN - Yu, Deborah. From the Departments of *Plastic and Maxillofacial Surgery, and +Pathology, University of Virginia Health System, Charlottesville, VA. TI - Comparison of Histological Characteristics of Acellular Dermal Matrix Capsules to Surrounding Breast Capsules in Acellular Dermal Matrix-Assisted Breast Reconstruction. SO - Annals of Plastic Surgery. 76(5):485-8, 2016 May AS - Ann Plast Surg. 76(5):485-8, 2016 May NJ - Annals of plastic surgery VO - 76 IP - 5 PG - 485-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Biopsy MH - *Breast/pa [Pathology] MH - Breast/su [Surgery] MH - *Breast Implantation/mt [Methods] MH - Female MH - Foreign-Body Reaction/et [Etiology] MH - *Foreign-Body Reaction/pa [Pathology] MH - Humans MH - Middle Aged MH - Postoperative Complications/et [Etiology] MH - *Postoperative Complications/pa [Pathology] MH - Prospective Studies MH - Single-Blind Method AB - INTRODUCTION: Despite the widespread adaptation of acellular dermal matrix (ADM) to breast reconstruction, we are just now exploring how these materials integrate and perform in vivo. The goal of this study was to compare the histological characteristics between expander capsules to an area without the ADM. AB - METHODS: Women undergoing implant-based breast reconstruction at the University of Virginia Health System using a decellularized regenerative dermal matrix were enrolled in this prospective, evaluator-blinded, institutional review board-approved study. Twenty-four non-ADM and 24 ADM breast capsule biopsy specimens were collected from 15 women and analyzed for the histological parameters of inflammation, vascular proliferation, capsule fibrosis, foreign body giant cell inflammatory reaction, and myofibroblasts using a previously described semiquantitative scoring system. The pathologist evaluating the specimens was blinded to the tissue source and biopsy location. AB - RESULTS: There was significantly less inflammation and fewer myofibroblasts in the ADM capsule biopsy samples compared with the no-ADM capsule biopsy samples (inflammation: ADM, 0.83; no-ADM, 1.83; P = 0.001; myofibroblasts: ADM, 0.79; no-ADM, 1.46; P = 0.024). Significantly less vascular proliferation in the ADM samples was seen compared with the no-ADM samples (ADM, 0.75; no-ADM, 1.42; P = 0.036). No statistical difference in the presence of an inflammatory capsule was observed in the no-ADM biopsy samples compared with the ADM capsule biopsy samples (P = 0.060). AB - CONCLUSIONS: When used for staged breast reconstruction, this unique, sterile ADM seems to induce less inflammation. Moreover, the significantly decreased presence of myofibroblasts in this material supports the observed clinical findings of decreased capsular contracture in ADM-assisted breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000368 PT - Clinical Trial PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0000000000000368 [doi] ID - 00000637-201605000-00005 [pii] PP - ppublish LG - English DP - 2016 May EZ - 2016/04/14 06:00 DA - 2017/01/10 06:00 DT - 2016/04/13 06:00 YR - 2016 ED - 20170109 RD - 20170110 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27070347 <86. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26530484 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Woo KJ AU - Paik JM AU - Mun GH AU - Pyon JK AU - Bang SI FA - Woo, Kyong-Je FA - Paik, Joo Myong FA - Mun, Goo-Hyun FA - Pyon, Jai-Kyong FA - Bang, Sa Ik IN - Woo, Kyong-Je. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Ilwon-ro, Gangnam-gu, Seoul, 135-710, Korea. IN - Paik, Joo Myong. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Ilwon-ro, Gangnam-gu, Seoul, 135-710, Korea. IN - Mun, Goo-Hyun. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Ilwon-ro, Gangnam-gu, Seoul, 135-710, Korea. IN - Pyon, Jai-Kyong. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Ilwon-ro, Gangnam-gu, Seoul, 135-710, Korea. IN - Bang, Sa Ik. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Ilwon-ro, Gangnam-gu, Seoul, 135-710, Korea. si55.bang@samsung.com. TI - Risk Factors for Complications in Immediate Expander-Implant Breast Reconstruction for Non-obese Patients: Impact of Breast Size on Complications. SO - Aesthetic Plastic Surgery. 40(1):71-8, 2016 Feb AS - Aesthetic Plast Surg. 40(1):71-8, 2016 Feb NJ - Aesthetic plastic surgery VO - 40 IP - 1 PG - 71-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Body Mass Index MH - *Breast/ah [Anatomy & Histology] MH - *Breast Implantation/ae [Adverse Effects] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Organ Size MH - *Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Radiotherapy, Adjuvant MH - Retrospective Studies MH - Time Factors MH - *Tissue Expansion Devices/ae [Adverse Effects] KW - Breast; Breast size; Complications; Obesity; Tissue expander AB - BACKGROUND: Although obesity is a well-known risk factor for complications in immediate expander-implant breast reconstruction, no studies have identified risk factors for non-obese patients. The purpose of this study was to identify risk factors for complications in non-obese patients. AB - METHODS: A retrospective analysis of prospectively collected data from 397 consecutive immediate expander-implant breast reconstructions in 367 non-obese patients at a single institution over a 5-year period was conducted. Univariable and multivariable analysis were performed to determine the influence of six patient-related and eight procedure-related characteristics on complications. AB - RESULTS: Mean BMI was 21.7 +/- 2 kg/m(2) and median mastectomy weight was 298.0 g (range: 40-1164 g). Multivariable analysis showed that neither BMI nor the use of acellular dermal matrix was a predictor for complications. Adjuvant radiation (odds = 3.12, p < 0.001) and mastectomy weight (p < 0.001) were independent risk factors for complications. A 100 g increase in the mastectomy weight was significantly associated with a 23 % increase in the odds of overall complications (p = 0.003), major complications (p = 0.004), and skin flap complications (p = 0.007), as well as a 28 % increase in the odds of seroma (p = 0.044), but was not associated with reconstruction failure. Adjuvant radiation (p < 0.001) and hypertension (p < 0.001) were risk factors for reconstruction failure. AB - CONCLUSIONS: Breast size was an independent risk factor for complications in non-obese patients while BMI was not. In the reconstruction of large breasts, greater attention and additional adjunctive procedures would be needed to prevent complications. AB - LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-015-0568-7 PT - Journal Article ID - 10.1007/s00266-015-0568-7 [doi] ID - 10.1007/s00266-015-0568-7 [pii] PP - ppublish PH - 2015/08/10 [received] PH - 2015/09/17 [accepted] LG - English EP - 20151103 DP - 2016 Feb EZ - 2015/11/05 06:00 DA - 2017/01/05 06:00 DT - 2015/11/05 06:00 YR - 2016 ED - 20170104 RD - 20170105 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26530484 <87. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26377531 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gerber B AU - Marx M AU - Untch M AU - Faridi A FA - Gerber, Bernd FA - Marx, Mario FA - Untch, Michael FA - Faridi, Andree IN - Gerber, Bernd. Department of Obstetrics and Gynecology, University of Rostock, Clinic for Plastic Surgery, Radebeul, Helios Klinikum Berlin Buch, Center for Breast Diseases, Vivantes Hospital am Urban, Berlin. TI - Breast Reconstruction Following Cancer Treatment. [Review][Erratum appears in Dtsch Arztebl Int. 2016 Apr 22;113(16):286; PMID: 27159143] CM - Comment in: Dtsch Arztebl Int. 2015 Aug 31;112(35-36):575-6; PMID: 26377528 CM - Comment in: Dtsch Arztebl Int. 2016 Apr 15;113(15):269; PMID: 27151465 CM - Comment in: Dtsch Arztebl Int. 2016 Apr 15;113(15):269-70; PMID: 27151466 CM - Comment in: Dtsch Arztebl Int. 2016 Apr 15;113(15):270; PMID: 27151467 SO - Deutsches Arzteblatt International. 112(35-36):593-600, 2015 Aug 31 AS - Dtsch. Arztebl. int.. 112(35-36):593-600, 2015 Aug 31 NJ - Deutsches Arzteblatt international VO - 112 IP - 35-36 PG - 593-600 PI - Journal available in: Print PI - Citation processed from: Internet JC - 101475967 IO - Dtsch Arztebl Int PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577667 SB - Index Medicus CP - Germany MH - Adult MH - Aged MH - Causality MH - Combined Modality Therapy/ut [Utilization] MH - Comorbidity MH - *Esthetics MH - Female MH - Humans MH - *Mammaplasty/ut [Utilization] MH - *Mastectomy/ut [Utilization] MH - Middle Aged MH - *Neoplasms/ep [Epidemiology] MH - *Neoplasms/su [Surgery] MH - *Postoperative Complications/ep [Epidemiology] MH - Prevalence MH - Risk Factors MH - Treatment Outcome AB - BACKGROUND: About 8000 breast reconstructions after mastectomy are per - formed in Germany each year. It has become more difficult to advise patients because of the wide variety of heterologous and autologous techniques that are now available and because of changes in the recommendations about radiotherapy. AB - METHODS: This article is based on a review of pertinent articles (2005-2014) that were retrieved by a selective search employing the search terms "mastectomy" and "breast reconstruction." AB - RESULTS: The goal of reconstruction is to achieve an oncologically safe and aestically satisfactory result for the patient over the long term. Heterologous, i.e., implant-based, breast reconstruction (IBR) and autologous breast reconstruction (ABR) are complementary techniques. Immediate reconstruction preserves the skin of the breast and its natural form and prevents the psychological trauma associated with mastectomy. If post-mastectomy radiotherapy (PMRT) is not indicated, implant-based reconstruction with or without a net/acellular dermal matrix (ADM) is a common option. Complications such as seroma formation, infection, and explantation are significantly more common when an ADM is used (15.3% vs. 5.4% ). If PMRT is performed, then the complication rate of implant-based breast reconstruction is 1 to 48% ; in particular, Baker grade III/IV capsular fibrosis occurs in 7 to 22% of patients, and the prosthesis must be explanted in 9 to 41% . Primary or, preferably, secondary autologous reconstruction is an alternative. The results of ABR are more stable over the long term, but the operation is markedly more complex. Autologous breast reconstruction after PMRT does not increase the risk of serious complications (20.5% vs. 17.9% without radiotherapy). AB - CONCLUSION: No randomized controlled trials have yet been conducted to compare the reconstructive techniques with each other. If radiotherapy will not be performed, immediate reconstruction with an implant is recommended. On the other hand, if post-mastectomy radiotherapy is indicated, then secondary autologous breast reconstruction is the procedure of choice. Future studies should address patients' quality of life and the long-term aesthetic results after breast reconstruction. ES - 1866-0452 IL - 1866-0452 DI - arztebl.2015.0593 DO - https://dx.doi.org/10.3238/arztebl.2015.0593 PT - Journal Article PT - Meta-Analysis PT - Review ID - arztebl.2015.0593 [pii] ID - 10.3238/arztebl.2015.0593 [doi] ID - PMC4577667 [pmc] PP - ppublish PH - 2015/03/05 [received] PH - 2015/06/10 [revised] PH - 2015/06/10 [accepted] LG - English DP - 2015 Aug 31 EZ - 2015/09/18 06:00 DA - 2016/12/15 06:00 DT - 2015/09/18 06:00 YR - 2015 ED - 20161213 RD - 20171228 UP - 20171228 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=26377531 <88. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26313677 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chao AH FA - Chao, Albert H IN - Chao, Albert H. Albert H. Chao, MD, is Assistant Professor in the Department of Plastic Surgery at Ohio State University and a board-certified plastic surgeon with specialty training in oncologic reconstructive surgery. His clinical practice focuses on oncologic reconstruction and microsurgery, and his research interests include patient outcomes and the role of technology. TI - A Review of the Use of Acellular Dermal Matrices in Postmastectomy Immediate Breast Reconstruction. [Review] SO - Plastic Surgical Nursing. 35(3):131-4; quiz 135-6, 2015 Jul-Sep AS - Plast Surg Nurs. 35(3):131-4; quiz 135-6, 2015 Jul-Sep NJ - Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses VO - 35 IP - 3 PG - 131-4; quiz 135-6 PI - Journal available in: Print PI - Citation processed from: Internet JC - 8403490, p8m IO - Plast Surg Nurs SB - Nursing Journal CP - United States MH - Acellular Dermis/ae [Adverse Effects] MH - *Acellular Dermis MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Female MH - Humans MH - *Mastectomy MH - Postoperative Complications/et [Etiology] MH - Time Factors MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion Devices AB - Acellular dermal matrices (ADMs) are now commonly used in postmastectomy implant-based immediate breast reconstruction. In 2-stage reconstructions involving placement of a tissue expander followed by an implant, they can improve the aesthetic outcome and expedite the expansion process. The use of ADMs has also allowed for 1-stage immediate placement of an implant following mastectomy (direct-to-implant reconstruction). However, the use of ADMs is associated with an increased risk of certain types of complications. An understanding of the use of these materials is essential to the postoperative care of patients who undergo ADM-assisted breast reconstruction. In this article, the use of ADMs in postmastectomy immediate breast reconstruction is reviewed. ES - 1550-1841 IL - 0741-5206 DO - https://dx.doi.org/10.1097/PSN.0000000000000103 PT - Journal Article PT - Review ID - 10.1097/PSN.0000000000000103 [doi] ID - 00006527-201507000-00010 [pii] PP - ppublish LG - English DP - 2015 Jul-Sep EZ - 2015/08/28 06:00 DA - 2016/12/15 06:00 DT - 2015/08/28 06:00 YR - 2015 ED - 20161213 RD - 20161230 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26313677 <89. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26438439 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lee KT AU - Mun GH FA - Lee, Kyeong-Tae FA - Mun, Goo-Hyun IN - Lee, Kyeong-Tae. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. IN - Mun, Goo-Hyun. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. supramicro@gmail.com. TI - Updated Evidence of Acellular Dermal Matrix Use for Implant-Based Breast Reconstruction: A Meta-analysis. SO - Annals of Surgical Oncology. 23(2):600-10, 2016 Feb AS - Ann Surg Oncol. 23(2):600-10, 2016 Feb NJ - Annals of surgical oncology VO - 23 IP - 2 PG - 600-10 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - b9r, 9420840 IO - Ann. Surg. Oncol. SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - *Breast Implants/ae [Adverse Effects] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - *Postoperative Complications MH - Prognosis AB - BACKGROUND: Although the use of acellular dermal matrix (ADM) has increased exponentially, debates regarding its safety are still ongoing. There have been several meta-analyses; however, potential learning curve effects of using ADM might affect their outcomes. The present meta-analysis reappraised the potential benefits and risks of ADM on the outcome of implant-based breast reconstruction using recent publications. AB - METHODS: Electronic databases were searched to identify relevant studies comparing the outcome of ADM use with traditional submuscular technique, which were published from 2011 to 2014. The relative risks of postoperative complications and mean difference of expander dynamics between the two groups were computed. AB - RESULTS: A total of 23 studies representing 6199 cases were analyzed. There was one randomized controlled study and three prospective cohort studies. The use of ADM significantly elevated the risks of infection, seroma, and mastectomy flap necrosis, but did not affect the risks of implant loss, unplanned reoperation, and total complications. The risks of capsular contracture and implant malposition were significantly reduced by the application of ADM. The ADM allows for significantly greater intraoperative expansion and reduced frequency of injection to complete expansion. AB - CONCLUSIONS: According to this meta-analysis, the increasing risks for serious complication and overall morbidity related to ADM use might not be remarkable, while its benefits for preventing late complications and improving expander dynamics might be appreciable. Although future well-controlled studies would be required, the implant-based breast reconstruction using ADM may be reliable and advantageous. ES - 1534-4681 IL - 1068-9265 DO - https://dx.doi.org/10.1245/s10434-015-4873-9 PT - Journal Article PT - Meta-Analysis ID - 10.1245/s10434-015-4873-9 [doi] ID - 10.1245/s10434-015-4873-9 [pii] PP - ppublish PH - 2015/03/26 [received] LG - English EP - 20151005 DP - 2016 Feb EZ - 2015/10/07 06:00 DA - 2016/10/26 06:00 DT - 2015/10/07 06:00 YR - 2016 ED - 20161025 RD - 20161230 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26438439 <90. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27689049 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Park GY AU - Yoon ES AU - Cho HE AU - Lee BI AU - Park SH FA - Park, Gui-Yong FA - Yoon, Eul-Sik FA - Cho, Hee-Eun FA - Lee, Byung-Il FA - Park, Seung-Ha IN - Park, Gui-Yong. Department of Plastic Surgery and Reconstructive Surgery, Korea University College of Medicine, Seoul, Korea. IN - Yoon, Eul-Sik. Department of Plastic Surgery and Reconstructive Surgery, Korea University College of Medicine, Seoul, Korea. IN - Cho, Hee-Eun. Department of Plastic Surgery and Reconstructive Surgery, Korea University College of Medicine, Seoul, Korea. IN - Lee, Byung-Il. Department of Plastic Surgery and Reconstructive Surgery, Korea University College of Medicine, Seoul, Korea. IN - Park, Seung-Ha. Department of Plastic Surgery and Reconstructive Surgery, Korea University College of Medicine, Seoul, Korea. TI - Acellular Dermal Matrix as a Core Strut for Projection in Nipple Reconstruction: Approaches for Three Different Methods of Breast Reconstruction. SO - Archives of Plastic Surgery. 43(5):424-9, 2016 Sep AS - Arch. plast. surg.. 43(5):424-9, 2016 Sep NJ - Archives of plastic surgery VO - 43 IP - 5 PG - 424-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg CP - Korea (South) KW - Acellular dermis; Mammaplasty; Nipples AB - BACKGROUND: The objective of this paper was to describe a novel technique for improving the maintenance of nipple projection in primary nipple reconstruction by using acellular dermal matrix as a strut in one of three different configurations, according to the method of prior breast reconstruction. The struts were designed to best fill the different types of dead spaces in nipple reconstruction depending on the breast reconstruction method. AB - METHODS: A total of 50 primary nipple reconstructions were performed between May 2012 and May 2015. The prior breast reconstruction methods were latissimus dorsi (LD) flap (28 cases), transverse rectus abdominis myocutaneous (TRAM) flap (10 cases), or tissue expander/implant (12 cases). The nipple reconstruction technique involved the use of local flaps, including the C-V flap or star flap. A 1x2-cm acellular dermal matrix was placed into the core with O-, I-, and L-shaped struts for prior LD, TRAM, and expander/implant methods, respectively. The projection of the reconstructed nipple was measured at the time of surgery and at 3, 6, and 9 months postoperatively. AB - RESULTS: The nine-month average maintenance of nipple projection was 73.0%+/-9.67% for the LD flap group using an O-strut, 72.0%+/-11.53% for the TRAM flap group using an I-strut, and 69.0%+/-10.82% for the tissue expander/implant group using an L-strut. There were no cases of infection, wound dehiscence, or flap necrosis. AB - CONCLUSIONS: The application of an acellular dermal matrix with a different kind of strut for each of 3 breast reconstruction methods is an effective addition to current techniques for improving the maintenance of long-term projection in primary nipple reconstruction. CI - No potential conflict of interest relevant to this article was reported. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2016.43.5.424 PT - Journal Article ID - PMC5040844 [pmc] ID - 10.5999/aps.2016.43.5.424 [doi] PP - ppublish PH - 2016/05/13 [received] PH - 2016/09/04 [revised] PH - 2016/09/08 [accepted] LG - English EP - 20160921 DP - 2016 Sep EZ - 2016/10/01 06:00 DA - 2016/10/01 06:01 DT - 2016/10/01 06:00 YR - 2016 ED - 20160930 RD - 20170224 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27689049 <91. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26377821 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Zhao X AU - Wu X AU - Dong J AU - Liu Y AU - Zheng L AU - Zhang L FA - Zhao, Xiangyi FA - Wu, Xiaowei FA - Dong, Jie FA - Liu, Yingying FA - Zheng, Liang FA - Zhang, Liming IN - Zhao, Xiangyi. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China. IN - Wu, Xiaowei. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China. 904949860@qq.com. IN - Dong, Jie. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China. IN - Liu, Yingying. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China. IN - Zheng, Liang. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China. IN - Zhang, Liming. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China. TI - A Meta-analysis of Postoperative Complications of Tissue Expander/Implant Breast Reconstruction Using Acellular Dermal Matrix. SO - Aesthetic Plastic Surgery. 39(6):892-901, 2015 Dec AS - Aesthetic Plast Surg. 39(6):892-901, 2015 Dec NJ - Aesthetic plastic surgery VO - 39 IP - 6 PG - 892-901 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - *Tissue Expansion Devices/ae [Adverse Effects] KW - Acellular dermal matrix; Breast reconstruction; Meta-analysis AB - BACKGROUND: Acellular dermal matrix (ADM) is commonly used for tissue expander/implant breast (TE/I-based) reconstruction. But the relation between ADM and postoperative complications remains controversial. A few meta-analyses were conducted in 2011-2012 and the result revealed that ADM can increase the risk of complications. The purpose of our study is to offer updated evidence for ADM clinical application by analyzing the effect of ADM on complications of TE/I-based breast reconstruction. AB - METHODS: The literature published from January 2010 to February 2015 was searched in EMbase, Medline, Science Direct, the Cochrane Central Register of Controlled Trials (CENTRAL), CBMdisc, CNKI, VIP, and the references of those included studies were also searched by hand. According to inclusive criteria, 11 studies were selected and the values were extracted from the included literature. Complications with four different categories assigned for overall complications, infection, hematoma/seroma, and explantation were collected. RevMan 5.1 was used for meta-analysis. The evidence level was assessed by using the GRADE system. AB - RESULTS: Eleven published studies were included. The results showed that compared to the control group, the ADM group increased the rate of overall complications (OR = 1.33, 95% CI 1.03-1.70, p = 0.03), infection (OR = 1.47, 95% CI 1.04-2.06, p = 0.03), hematoma/seroma (OR = 1.66, 95% CI 1.13-2.44, p = 0.01), but there was no significant difference in explantation (OR = 1.37, 95% CI 0.89-2.11, p = 0.15). Based on the GRADE system, all the evidence was at level C and weak recommendation. AB - CONCLUSIONS: In TE/I-based breast reconstruction, ADM increased the incidence of overall complications, infection, and hematoma/seroma; the incidence of explantation remains unknown. For the poor quality of the original studies, a prudent choice is suggested; and more high-quality, large-sample studies are needed. AB - NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266. ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-015-0555-z PT - Journal Article PT - Meta-Analysis ID - 10.1007/s00266-015-0555-z [doi] ID - 10.1007/s00266-015-0555-z [pii] PP - ppublish PH - 2015/06/04 [received] PH - 2015/08/12 [accepted] LG - English EP - 20150916 DP - 2015 Dec EZ - 2015/09/18 06:00 DA - 2016/09/16 06:00 DT - 2015/09/18 06:00 YR - 2015 ED - 20160915 RD - 20151121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26377821 <92. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27622099 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Qureshi AA AU - Broderick K AU - Funk S AU - Reaven N AU - Tenenbaum MM AU - Myckatyn TM FA - Qureshi, Ali A FA - Broderick, Kristen FA - Funk, Susan FA - Reaven, Nancy FA - Tenenbaum, Marissa M FA - Myckatyn, Terence M IN - Qureshi, Ali A. Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo. Strategic Health Resources. IN - Broderick, Kristen. Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo. Strategic Health Resources. IN - Funk, Susan. Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo. Strategic Health Resources. IN - Reaven, Nancy. Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo. Strategic Health Resources. IN - Tenenbaum, Marissa M. Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo. Strategic Health Resources. IN - Myckatyn, Terence M. Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo. Strategic Health Resources. TI - Direct Hospital Cost of Outcome Pathways in Implant-Based Reconstruction with Acellular Dermal Matrices. SO - Plastic and Reconstructive Surgery - Global Open. 4(8):e831, 2016 Aug AS - Plast. reconstr. surg., Glob. open. 4(8):e831, 2016 Aug NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 8 PG - e831 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010322 CP - United States AB - BACKGROUND: Current cost data on tissue expansion followed by exchange for permanent implant (TE/I) reconstruction lack a necessary assessment of the experience of a heterogenous breast cancer patient population and their multiple outcome pathways. We extend our previous analysis to that of direct hospital cost as bundling of payments is likely to follow the changing centralization of cancer care at the hospital level. AB - METHODS: We performed a retrospective analysis (2003-2009) of TE/I reconstructions with or without an acellular dermal matrix (ADM), namely Alloderm RTM. Postreconstructive events were analyzed and organized into outcome pathways as previously described. Aggregated and normalized inpatient and outpatient hospital direct costs and physician reimbursement were generated for each outcome pathway with or without ADM. AB - RESULTS: Three hundred sixty-seven patients were analyzed. The average 2-year hospital direct cost per TE/I breast reconstruction patient was $11,862 in the +ADM and $12,319 in the -ADM groups (P > 0.05). Initial reconstructions were costlier in the +ADM ($6,868) than in the -ADM ($5,615) group, but the average cost of subsequent postreconstructive events within 2 years was significantly lower in +ADM ($5,176) than -ADM ($6,704) patients (P < 0.05). When a complication occurred, but reconstruction was still completed within 2 years, greater costs were incurred in the -ADM than in the +ADM group for most scenarios, leading to a net equalization of cost between study groups. AB - CONCLUSION: Although direct hospital cost is an important factor for resource and fund allocation, it should not remain the sole factor when deciding to use ADM in TE/I reconstruction. CI - Dr. Myckatyn receives grant funding from Lifecell Corporation. Funds from Lifecell Corporation were used to pay for third party statistician and salaries of data abstractors at Washington University. The Article Processing Charge was paid for by the authors. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000848 PT - Journal Article ID - 10.1097/GOX.0000000000000848 [doi] ID - PMC5010322 [pmc] PP - epublish PH - 2016/05/13 [received] PH - 2016/06/17 [accepted] LG - English EP - 20160809 DP - 2016 Aug EZ - 2016/09/14 06:00 DA - 2016/09/14 06:01 DT - 2016/09/14 06:00 YR - 2016 ED - 20160913 RD - 20170224 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27622099 <93. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27621667 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Ooi ASh AU - Song DH FA - Ooi, Adrian Sh FA - Song, David H IN - Ooi, Adrian Sh. Section of Plastic and Reconstructive Surgery, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA; Department of Plastic, Reconstructive, and Aesthetic Surgery, Singapore General Hospital, Singapore. IN - Song, David H. Section of Plastic and Reconstructive Surgery, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA. TI - Reducing infection risk in implant-based breast-reconstruction surgery: challenges and solutions. [Review] SO - Breast Cancer Targets and Therap. 8:161-72, 2016 AS - Breast Cancer (Dove Med Press). 8:161-72, 2016 NJ - Breast cancer (Dove Medical Press) VO - 8 PG - 161-72 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101591856 IO - Breast Cancer (Dove Med Press) PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012596 CP - New Zealand KW - acellular dermal matrix; implant infection; risk reduction AB - Implant-based procedures are the most commonly performed method for postmastectomy breast reconstruction. While donor-site morbidity is low, these procedures are associated with a higher risk of reconstructive loss. Many of these are related to infection of the implant, which can lead to prolonged antibiotic treatment, undesired additional surgical procedures, and unsatisfactory results. This review combines a summary of the recent literature regarding implant-related breast-reconstruction infections and combines this with a practical approach to the patient and surgery aimed at reducing this risk. Prevention of infection begins with appropriate reconstructive choice based on an assessment and optimization of risk factors. These include patient and disease characteristics, such as smoking, obesity, large breast size, and immediate reconstructive procedures, as well as adjuvant therapy, such as radiotherapy and chemotherapy. For implant-based breast reconstruction, preoperative planning and organization is key to reducing infection. A logical and consistent intraoperative and postoperative surgical protocol, including appropriate antibiotic choice, mastectomy-pocket creation, implant handling, and considered acellular dermal matrix use contribute toward the reduction of breast-implant infections. IS - 1179-1314 IL - 1179-1314 DO - https://dx.doi.org/10.2147/BCTT.S97764 PT - Journal Article PT - Review ID - 10.2147/BCTT.S97764 [doi] ID - bctt-8-161 [pii] ID - PMC5012596 [pmc] PP - epublish LG - English EP - 20160901 DP - 2016 EZ - 2016/09/14 06:00 DA - 2016/09/14 06:01 DT - 2016/09/14 06:00 YR - 2016 ED - 20160913 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27621667 <94. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27602176 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Zenn MR AU - Salzberg CA FA - Zenn, Michael R FA - Salzberg, C Andrew IN - Zenn, Michael R. Duke University Medical Center, Durham, NC. IN - Salzberg, C Andrew. Icahn School of Medicine, Mount Sinai Health System, New York. TI - A Direct Comparison of Alloderm-Ready to Use (RTU) and DermACELL in Immediate Breast Implant Reconstruction. SO - Eplasty [Electronic Resource]. 16:e23, 2016 AS - Eplasty. 16:e23, 2016 NJ - Eplasty VO - 16 PG - e23 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993036 CP - United States KW - ADM; Alloderm; DermACELL; breast implants; breast reconstruction AB - The objective of this study was to compare the 2 leading human acellular dermal matrices in breast reconstruction with implants. This retrospective study draws on the experience of 2 expert surgeons with a history of long-standing use of the Alloderm-RTU (LifeCell Corporation, Branchburg, NJ) product who switched to the DermACELL acellular dermal matrix (LifeNet Health, Virgina Beach, Va) product. The consecutive nature of these data over this change allowed comparison between the 2 products without the confounding effects of patient selection or change in technique. The postoperative complications of seroma, infection, implant loss, and unplanned return to the operating room were studied, and no statistical differences were noted between these 2 products. The overall complications rates were low, with implant loss and infection less than 2% in 249 cases. Recommendations are for continued use of acellular dermal matrix in breast reconstruction and product selection based on price and availability. IS - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC4993036 [pmc] PP - epublish LG - English EP - 20160811 DP - 2016 EZ - 2016/09/08 06:00 DA - 2016/09/08 06:01 DT - 2016/09/08 06:00 YR - 2016 ED - 20160907 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27602176 <95. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27579264 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Daar DA AU - Gandy JR AU - Clark EG AU - Mowlds DS AU - Paydar KZ AU - Wirth GA FA - Daar, David A FA - Gandy, Jessica R FA - Clark, Emily G FA - Mowlds, Donald S FA - Paydar, Keyianoosh Z FA - Wirth, Garrett A IN - Daar, David A. Department of Plastic Surgery, University of California, Irvine, Orange, CA. IN - Gandy, Jessica R. Department of Plastic Surgery, University of California, Irvine, Orange, CA. IN - Clark, Emily G. Department of Plastic Surgery, University of California, Irvine, Orange, CA. IN - Mowlds, Donald S. Department of Plastic Surgery, University of California, Irvine, Orange, CA. IN - Paydar, Keyianoosh Z. Department of Plastic Surgery, University of California, Irvine, Orange, CA. IN - Wirth, Garrett A. Department of Plastic Surgery, University of California, Irvine, Orange, CA. TI - Plastic Surgery and Acellular Dermal Matrix: Highlighting Trends from 1999 to 2013. [Review] SO - World Journal of Plastic Surgery. 5(2):97-108, 2016 May AS - World j. plast. surg.. 5(2):97-108, 2016 May NJ - World journal of plastic surgery VO - 5 IP - 2 PG - 97-108 PI - Journal available in: Print PI - Citation processed from: Print JC - 101639130 IO - World J Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003944 CP - Iran KW - Acellular dermal matrix; Bibliometrics; Global; Trends AB - The last decade has ushered in a rapidly expanding global discussion regarding acellular dermal matrix (ADM) applications, economic analyses, technical considerations, benefits, and risks, with recent emphasis on ADM use in breast surgery. This study aims to evaluate global trends in ADM research using bibliometric analysis. The top nine Plastic Surgery journals were determined by impact factor (IF). Each issue of the nine journals between 1999 and 2013 was accessed to compile a database of articles discussing ADM. Publications were further classified by IF, authors' geographic location, study design, and level of evidence (LOE, I-V). Productivity index and productivity share were calculated for each region. In total, 256 ADM articles were accessed. The annual global publication volume increased significantly by 4.2 (0.87) articles per year (p<0.001), with a mean productivity index of 36.3 (59.0). The mean impact factor of the nine journals increased significantly from 0.61 (0.11) to 2.47 (0.99) from 1993 to 2013 (p<0.001). Despite this increase in the global ADM literature, the majority of research was of weaker LOE (level I: 2.29% and level II: 9.17%). USA contributed the most research (87%), followed by Asia (4.76%) and Western Europe (4.71%). USA contributed the greatest volume of research. Regarding clinical application of ADM, the majority of publications focused on ADM use in breast surgery, specifically breast reconstruction (154 articles, 60.2%). The majority of research was of lower LOE; thus, efforts should be made to strengthen the body of literature, particularly with regard to cost analysis. IS - 2228-7914 IL - 2228-7914 PT - Journal Article PT - Review ID - PMC5003944 [pmc] PP - ppublish LG - English DP - 2016 May EZ - 2016/09/01 06:00 DA - 2016/09/01 06:01 DT - 2016/09/01 06:00 YR - 2016 ED - 20160831 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27579264 <96. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27579223 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University, Washington, DC. TI - Prosthetic Breast Reconstruction With Acellular Dermal Matrices: Achieving Predictability and Reproducibility. CM - Comment in: Plast Reconstr Surg. 2017 Oct;140(4):641e-643e; PMID: 28953753 SO - Plastic and Reconstructive Surgery - Global Open. 4(5):e698, 2016 May AS - Plast. reconstr. surg., Glob. open. 4(5):e698, 2016 May NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 5 PG - e698 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995706 CP - United States AB - The use of acellular dermal matrices in the setting of prosthetic breast reconstruction has captured the attention of many plastic surgeons. The regenerative capacity of these materials has provided additional tissue support to the mastectomy skin flaps with the ultimate result of improving surgical and aesthetic outcomes. Despite the benefits, there remains a significant diversity with regard to outcomes with some surgeons reporting increased morbidity. The reasons for this are varied but ultimately related to differences in patient selection and surgical techniques. The purpose of this article is to provide strategies for using acellular dermal matrix to achieve success in a manner that is usually associated with outcomes that are predictable and reproducible. CI - Dr. Nahabedian is a consultant for LifeCell. No assistance was obtained in preparation of this manuscript. The Article Processing Charge was paid by LifeCell. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000459 PT - Journal Article ID - 10.1097/GOX.0000000000000459 [doi] ID - PMC4995706 [pmc] PP - epublish PH - 2015/05/18 [received] PH - 2015/06/25 [accepted] LG - English EP - 20160504 DP - 2016 May EZ - 2016/09/01 06:00 DA - 2016/09/01 06:01 DT - 2016/09/01 06:00 YR - 2016 ED - 20160831 RD - 20171113 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27579223 <97. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26947961 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gschwantler-Kaulich D AU - Schrenk P AU - Bjelic-Radisic V AU - Unterrieder K AU - Leser C AU - Fink-Retter A AU - Salama M AU - Singer C FA - Gschwantler-Kaulich, D FA - Schrenk, P FA - Bjelic-Radisic, V FA - Unterrieder, K FA - Leser, C FA - Fink-Retter, A FA - Salama, M FA - Singer, C IN - Gschwantler-Kaulich, D. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: daphne.gschwantler@kaulich.at. IN - Schrenk, P. AKH Linz Breast Cancer Center, Krankenhausstrasse 9, 4021 Linz, Austria. IN - Bjelic-Radisic, V. Medical University of Graz, Department of Gynaecology, Auenbruggerplatz 1, 8036 Graz, Austria. IN - Unterrieder, K. Private Hospital Villach, Breast Cancer Center, Department of Gynaecology, Dr.-Walter-Hochsteiner-Strase 4, 9504 Villach, Austria. IN - Leser, C. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. IN - Fink-Retter, A. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. IN - Salama, M. Otto Wagner Hospital, Department of Surgery, Baumgartner Hoehe 1, 1140 Vienna, Austria. IN - Singer, C. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. TI - Mesh versus acellular dermal matrix in immediate implant-based breast reconstruction - A prospective randomized trial.[Erratum appears in Eur J Surg Oncol. 2017 Jul;43(7):1380-1381; PMID: 28526188] CM - Comment in: Eur J Surg Oncol. 2016 Nov;42(11):1767-1768; PMID: 27424788 SO - European Journal of Surgical Oncology. 42(5):665-71, 2016 May AS - Eur J Surg Oncol. 42(5):665-71, 2016 May NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 42 IP - 5 PG - 665-71 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis/ut [Utilization] MH - Austria MH - *Breast Implants MH - Esthetics MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Patient Satisfaction MH - Pilot Projects MH - Postoperative Complications MH - Prospective Studies MH - Quality of Life MH - Surgical Mesh MH - Surveys and Questionnaires KW - Acellular dermal matrix; Breast; Mesh; Reconstruction AB - BACKGROUND: Comparative studies on the use of meshes and acellular dermal matrices (ADM) in implant-based breast reconstruction (IBBR) have not yet been performed. AB - METHODS: This prospective, randomized, controlled, multicenter pilot study was performed at four Austrian breast cancer centers. Fifty patients with oncologic or prophylactic indication for mastectomy and IBBR were randomized to immediate IBBR with either an ADM (Protexa()) or a titanized mesh (TiLOOP() Bra). Complications, failed reconstruction, cosmetic outcome, patients' quality of life and the thickness of the overlying tissue were recorded immediately postoperatively and 3 and 6 months after surgery. AB - RESULTS: 48 patients participated in the study (Protexa() group: 23; TiLOOP() Bra group: 25 patients). The overall complication rate was 31.25% with similar rates in both groups (Protexa() group: 9 versus TiLOOP() Bra group: 6; p = 0.188). There was a higher incidence of severe complications leading to failed reconstructions with implant loss in the Protexa() group than in the TiLOOP() Bra group (7 versus 2; p < 0.0001). An inverted T-incision technique led to significantly more complications and reconstructive failure with Protexa() (p = 0.037, p = 0.012, respectively). There were no significant differences in patients' satisfaction with cosmetic results (p = 0.632), but surgeons and external specialists graded significantly better outcomes with TiLOOP() Bra (p = 0.034, p = 0.032). AB - CONCLUSION: This pilot study showed use of TiLOOP() Bra or Protexa() in IBBR is feasible leading to good cosmetic outcomes and high patient satisfaction. To validate the higher failure rates in the Protexa() group, data from a larger trial are required. NCT02562170. Copyright © 2016 Elsevier Ltd. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(16)00101-3 DO - https://dx.doi.org/10.1016/j.ejso.2016.02.007 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't ID - S0748-7983(16)00101-3 [pii] ID - 10.1016/j.ejso.2016.02.007 [doi] PP - ppublish PH - 2015/09/30 [received] PH - 2016/01/21 [revised] PH - 2016/02/02 [accepted] SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT02562170 SL - https://clinicaltrials.gov/search/term=NCT02562170 LG - English EP - 20160223 DP - 2016 May EZ - 2016/03/08 06:00 DA - 2016/08/23 06:00 DT - 2016/03/08 06:00 YR - 2016 ED - 20160822 RD - 20170907 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26947961 <98. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27536502 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lyons DA AU - Mendenhall SD AU - Neumeister MW AU - Cederna PS AU - Momoh AO FA - Lyons, Daniel A FA - Mendenhall, Shaun D FA - Neumeister, Michael W FA - Cederna, Paul S FA - Momoh, Adeyiza O IN - Lyons, Daniel A. Section of Plastic Surgery, University of Michigan School of Medicine, Ann Arbor, Mich.; and Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill. IN - Mendenhall, Shaun D. Section of Plastic Surgery, University of Michigan School of Medicine, Ann Arbor, Mich.; and Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill. IN - Neumeister, Michael W. Section of Plastic Surgery, University of Michigan School of Medicine, Ann Arbor, Mich.; and Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill. IN - Cederna, Paul S. Section of Plastic Surgery, University of Michigan School of Medicine, Ann Arbor, Mich.; and Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill. IN - Momoh, Adeyiza O. Section of Plastic Surgery, University of Michigan School of Medicine, Ann Arbor, Mich.; and Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill. TI - Aseptic versus Sterile Acellular Dermal Matrices in Breast Reconstruction: An Updated Review. SO - Plastic and Reconstructive Surgery - Global Open. 4(7):e823, 2016 Jul AS - Plast. reconstr. surg., Glob. open. 4(7):e823, 2016 Jul NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 7 PG - e823 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977151 CP - United States AB - BACKGROUND: As the use of acellular dermal matrices in breast reconstruction has become more commonplace and efforts are made to improve on postoperative outcomes, the method of acellular dermal matrix (ADM) processing (aseptic versus sterile) has become a subject of interest. This article provides an updated overview of the critical aspects of ADM processing in addition to application of ADMs in single- and two-stage breast reconstruction, a review of the morbidity associated with ADM use, and alternatives. AB - METHODS: A literature review was performed in PubMed identifying recent systematic reviews, meta-analyses, and head-to-head comparisons on aseptically processed ADM and sterile-processed ADM in implant-based breast reconstruction. AB - RESULTS: Recent meta-analyses have shown a 2- to 3-fold increase in infections and tissue expander/implant explantation rates and a 3- to 4-fold increase in seroma formation compared with non-ADM reconstruction techniques. Comparisons of aseptic and sterile ADMs in multiple studies have shown no significant difference in infection rates and equivocal findings for other specific complications such as seroma formation. AB - CONCLUSIONS: Current evidence on the impact of processing techniques that improve ADM sterility on postoperative morbidity in implant breast reconstruction is unclear. Deficiencies of the available data highlight the need for well-designed, multicenter, randomized controlled studies that will aid in optimizing outcomes in implant-based breast reconstruction. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000819 PT - Journal Article ID - 10.1097/GOX.0000000000000819 [doi] ID - PMC4977151 [pmc] PP - epublish PH - 2016/02/02 [received] PH - 2016/05/15 [accepted] LG - English EP - 20160722 DP - 2016 Jul EZ - 2016/08/19 06:00 DA - 2016/08/19 06:01 DT - 2016/08/19 06:00 YR - 2016 ED - 20160818 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27536502 <99. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27536500 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Downs RK AU - Hedges K FA - Downs, Ronald K FA - Hedges, Kellee IN - Downs, Ronald K. Department of Plastic Surgery, Indiana University School of Medicine, Indianapolis, Ind.; Department of Image Recovery, St. Joseph Regional Medical Center, Mishawaka, Ind.; and The Centre, P.C. Comprehensive Plastic Surgery, The Centre PC, Mishawaka, Ind. IN - Hedges, Kellee. Department of Plastic Surgery, Indiana University School of Medicine, Indianapolis, Ind.; Department of Image Recovery, St. Joseph Regional Medical Center, Mishawaka, Ind.; and The Centre, P.C. Comprehensive Plastic Surgery, The Centre PC, Mishawaka, Ind. TI - An Alternative Technique for Immediate Direct-to-Implant Breast Reconstruction-A Case Series. SO - Plastic and Reconstructive Surgery - Global Open. 4(7):e821, 2016 Jul AS - Plast. reconstr. surg., Glob. open. 4(7):e821, 2016 Jul NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 7 PG - e821 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977149 CP - United States AB - BACKGROUND: The practice of breast reconstruction continues to evolve with the introduction of new technologies. The authors describe a unique approach allowing immediate direct-to-implant reconstruction that can be performed on an outpatient basis. AB - METHODS: After a nipple-sparing mastectomy, acellular dermal matrix (ADM)-covered implants are placed in a prepectoral position in an immediate reconstruction. Assessment of results was performed via a retrospective review of demographic and procedural data. AB - RESULTS: Forty-five patients (79 breasts), mean age 46.8 years, were treated with direct-to-implant reconstruction using ADM-wrapped implants placed above the muscle with mean follow-up of 23.1 months (median 22 mo). Mean body mass index was 24.3, and 15 patients (33.3%) were current or former smokers. Twenty-seven patients (60%) had prior breast surgery with 22 (49%) exposed to chemotherapy and 34 (76%) radiation. Procedure time averaged 155 minutes and hospital length of stay averaged 0.6 days. Complications included flap necrosis in 22 cases (28%), seroma in 12 (15%), infection in 8 (10%), rippling in 28 (35%), and contracture in 8 (10%). In 14 breasts (18%), postoperative wound complications (flap necrosis or infection) led to implant loss. AB - CONCLUSIONS: The availability of ADM and cohesive gel implants has allowed us to perform above-the-muscle implant breast reconstruction in reduced time and often on an outpatient basis. Complication rates were comparable to expected results of standard expander-to-implant, staged breast reconstruction. This technique is a viable option delivering clinically and aesthetically acceptable results in select patients. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000839 PT - Journal Article ID - 10.1097/GOX.0000000000000839 [doi] ID - PMC4977149 [pmc] PP - epublish PH - 2016/04/08 [received] PH - 2016/06/08 [accepted] LG - English EP - 20160722 DP - 2016 Jul EZ - 2016/08/19 06:00 DA - 2016/08/19 06:01 DT - 2016/08/19 06:00 YR - 2016 ED - 20160818 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27536500 <100. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27536479 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Keifer OP Jr AU - Page EK AU - Hart A AU - Rudderman R AU - Carlson GW AU - Losken A FA - Keifer, Orion P Jr FA - Page, Eugenia K FA - Hart, Alexandra FA - Rudderman, Randall FA - Carlson, Grant W FA - Losken, Albert IN - Keifer, Orion P Jr. Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga. IN - Page, Eugenia K. Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga. IN - Hart, Alexandra. Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga. IN - Rudderman, Randall. Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga. IN - Carlson, Grant W. Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga. IN - Losken, Albert. Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta, Ga.; and Private Practice, Atlanta, Ga. TI - A Complication Analysis of 2 Acellular Dermal Matrices in Prosthetic-based Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 4(7):e800, 2016 Jul AS - Plast. reconstr. surg., Glob. open. 4(7):e800, 2016 Jul NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 7 PG - e800 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977128 CP - United States AB - BACKGROUND: Acellular dermal matrices (ADM) are now routine in postmastectomy prosthetic-based breast reconstruction. The goal of the current study was to compare the complications of 2 ADM products-AlloDerm and Cortiva. AB - METHODS: A retrospective analysis of prosthetic-based breast reconstruction in Atlanta, Ga., over 5 years. Inclusion criteria were the use of the ADM types (AlloDerm or Cortiva) and use of a tissue expander or implant. Statistical analysis compared group demographics, risk factors, and early complications. AB - RESULTS: Of the 298 breast reconstructions, 174 (58.4%) used AlloDerm and 124 (41.6%) used Cortiva. There was no difference in overall complication frequency (16 AlloDerm and 18 Cortiva; P = 0.195). Within specific categories, there was a difference in mastectomy skin flap necrosis, but, based on further regression analysis, this was attributable to differences in body mass index (P = 0.036). Furthermore, there were no differences in the rates of infection (6 AlloDerm and 5 Cortiva; P = 1.0), seroma/hematoma (9 AlloDerm and 7 Cortiva; P = 1.0), or drain duration (13.2 day AlloDerm and 14.2 day Cortiva, P = 0.2). By using a general estimating equation for binomial logistical regression, it was found that only current tobacco use (P = 0.033) was a significant predictor for a complication. Trending predictors were body mass index (P = 0.074) and age (P = 0.093). The type of matrix was not a significant predictor for any of the recorded complication (P = 0.160). AB - CONCLUSIONS: Although AlloDerm is well established, we have shown that Cortiva has an equivalent complication frequency. Future work will focus on long-term outcome measures and histological evaluation of vascularization and integration. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000790 PT - Journal Article ID - 10.1097/GOX.0000000000000790 [doi] ID - PMC4977128 [pmc] PP - epublish PH - 2016/03/28 [received] PH - 2016/04/27 [accepted] GI - No: T32 GM008169 Organization: (GM) *NIGMS NIH HHS* Country: United States LG - English EP - 20160713 DP - 2016 Jul EZ - 2016/08/19 06:00 DA - 2016/08/19 06:01 DT - 2016/08/19 06:00 YR - 2016 ED - 20160818 RD - 20170512 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27536479 <101. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26313265 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wang D AU - Hu K AU - Gao N AU - Zhang H AU - Jiang Y AU - Liu C AU - Wang S AU - Zhao Z FA - Wang, Dan FA - Hu, Kebang FA - Gao, Ningning FA - Zhang, Hao FA - Jiang, Yanlin FA - Liu, Caigang FA - Wang, Shouyu FA - Zhao, Zuowei IN - Wang, Dan. Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, China 116023. IN - Hu, Kebang. Department of Urology, First Hospital of Jilin University, Changchun, China 130021. IN - Gao, Ningning. Ultrasonic Diagnosis Department, The First Hospital of China Medical University, Shenyang, China 110001. IN - Zhang, Hao. Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, China 116023. IN - Jiang, Yanlin. Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, China 116023. IN - Liu, Caigang. Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, China 116023. IN - Wang, Shouyu. Department of Surgery, The First Hospital of Dalian Medical University, Dalian, China 114000. IN - Zhao, Zuowei. Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, China 116023. TI - High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery. SO - Oncotarget. 6(30):29296-310, 2015 Oct 06 AS - Oncotarget. 6(30):29296-310, 2015 Oct 06 NJ - Oncotarget VO - 6 IP - 30 PG - 29296-310 PI - Journal available in: Print PI - Citation processed from: Internet JC - 101532965 IO - Oncotarget PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745727 SB - Index Medicus CP - United States MH - *Body Fluids/en [Enzymology] MH - *Breast Neoplasms/en [Enzymology] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cell Movement MH - Cell Proliferation MH - *Chemokines/me [Metabolism] MH - Chemotherapy, Adjuvant MH - *Cytokines/me [Metabolism] MH - Disease Progression MH - Female MH - *High-Throughput Screening Assays MH - Humans MH - MCF-7 Cells MH - *Mastectomy/ae [Adverse Effects] MH - *Matrix Metalloproteinases/me [Metabolism] MH - Neoplasm Recurrence, Local MH - Neoplasm Staging MH - Signal Transduction MH - Time Factors MH - Treatment Outcome MH - *Wound Healing KW - breast cancer; proliferation; wound fluid AB - OBJECTIVE: To clarify the composition of wound fluid (WF) and investigate the impact of WF on breast cancer cell lines. AB - METHODS: The proliferation and migration of WF-treated breast cancer cells MDA-MB-231 and MCF-7 were assessed with colony formation test, MTT cell proliferation test and scratch wound test. The quantitative profiles of WF were analyzed using Bio-Plex Pro kits. AB - RESULTS: The proliferation and migration of WF-treated breast cancer cells were significantly higher than that of untreated cells. Fifteen cytokines, 29 chemokines and 9 matrix metalloproteinases (MMPs) were assessed in WF. The concentrations of these factors were influenced by post-surgery days, neoadjuvant chemotherapy (NAC), TNM stage, pathological type and molecular subtype. The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20. AB - CONCLUSIONS: Surgery-induced WF promotes the proliferation and migration of breast cancer cells. The composition of WF is influenced by various clinical features and provides potential therapeutic targets to control local recurrence and tumor progression. RN - 0 (Chemokines) RN - 0 (Cytokines) RN - EC 3-4-24 (Matrix Metalloproteinases) ES - 1949-2553 IL - 1949-2553 DO - https://dx.doi.org/10.18632/oncotarget.4828 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 4828 [pii] ID - 10.18632/oncotarget.4828 [doi] ID - PMC4745727 [pmc] PP - ppublish PH - 2015/03/30 [received] PH - 2015/07/29 [accepted] LG - English DP - 2015 Oct 06 EZ - 2015/08/28 06:00 DA - 2016/08/12 06:00 DT - 2015/08/28 06:00 YR - 2015 ED - 20160811 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26313265 <102. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27018669 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hidalgo DA AU - Sinno S FA - Hidalgo, David A FA - Sinno, Sammy IN - Hidalgo, David A. New York, N.Y. From the Division of Plastic Surgery, Weill Cornell Medical College; and the Department of Plastic Surgery, New York University Medical Center. TI - Current Trends and Controversies in Breast Augmentation. SO - Plastic & Reconstructive Surgery. 137(4):1142-50, 2016 Apr AS - Plast Reconstr Surg. 137(4):1142-50, 2016 Apr NJ - Plastic and reconstructive surgery VO - 137 IP - 4 PG - 1142-50 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Attitude of Health Personnel MH - Dissent and Disputes MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - Mammaplasty/mt [Methods] MH - Mammaplasty/sn [Statistics & Numerical Data] MH - *Mammaplasty/td [Trends] MH - Perioperative Care/mt [Methods] MH - Perioperative Care/sn [Statistics & Numerical Data] MH - Practice Patterns, Physicians'/sn [Statistics & Numerical Data] MH - *Practice Patterns, Physicians'/td [Trends] MH - United States AB - BACKGROUND: A survey was conducted to study current attitudes and common practices in breast augmentation. AB - METHODS: A 35-item electronic questionnaire was sent to the entire active American Society of Plastic Surgeons membership. It was divided into current controversies, new technologies, common practices, secondary procedures, and member demographics. AB - RESULTS: There were 1067 respondents. Fifty percent of surgeons never use anatomically shaped implants and another 42 percent do so less than half the time. Autologous fat is used infrequently as a primary technique but more often as a supplemental technique. Approximately 7 percent report a case of anaplastic large cell lymphoma. Eighty-five percent do not use preoperative three-dimensional imaging. More than half of surgeons use acellular dermal matrix in secondary procedures. Approximately half do not use insertion funnels. Preoperative sizing with silicone implants, inframammary incisions, partial submuscular pockets, and smooth silicone implants larger than 300 cc are dominant practice preferences. Postoperative massage is still popular with over half of respondents. Just over half do not use pharmacologic agents for capsular contracture. Capsular contracture and size change were the most frequent reasons for reoperation. Capsular contracture is typically treated with anterior capsulectomy the first time, and either total capsulectomy or anterior capsulectomy with acellular dermal matrix use when recurrent. Almost half of respondents perform fewer than 50 breast augmentations yearly. AB - CONCLUSIONS: There is an established most common approach to breast augmentation among respondents. Most surgeons are slow to embrace controversial practices and to adopt new technologies, although acellular dermal matrix use is becoming more popular. The 7 percent incidence of anaplastic large cell lymphoma was noteworthy. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000481110.31939.e4 PT - Journal Article PT - Video-Audio Media ID - 10.1097/01.prs.0000481110.31939.e4 [doi] ID - 00006534-201604000-00010 [pii] PP - ppublish LG - English DP - 2016 Apr EZ - 2016/03/29 06:00 DA - 2016/08/09 06:00 DT - 2016/03/29 06:00 YR - 2016 ED - 20160808 RD - 20160329 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27018669 <103. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27018665 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jordan SW AU - Khavanin N AU - Kim JY FA - Jordan, Sumanas W FA - Khavanin, Nima FA - Kim, John Y S IN - Jordan, Sumanas W. Chicago, Ill. From the Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine. TI - Seroma in Prosthetic Breast Reconstruction. [Review] CM - Comment in: Plast Reconstr Surg. 2017 Aug;140(2):347e-348e; PMID: 28376029 SO - Plastic & Reconstructive Surgery. 137(4):1104-16, 2016 Apr AS - Plast Reconstr Surg. 137(4):1104-16, 2016 Apr NJ - Plastic and reconstructive surgery VO - 137 IP - 4 PG - 1104-16 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Implantation MH - Female MH - Humans MH - Incidence MH - Models, Statistical MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/pc [Prevention & Control] MH - Risk Factors MH - Seroma/ep [Epidemiology] MH - *Seroma/et [Etiology] MH - Seroma/pp [Physiopathology] MH - Seroma/pc [Prevention & Control] AB - BACKGROUND: Seroma, as a complication of prosthetic breast reconstruction, results in patient distress, increased office visits, undesirable aesthetic outcomes, and--importantly--may escalate to infection and frank prosthesis loss. Herein, the authors review the pathophysiology and risk factors and attempt to collate published practices for avoidance and management of seroma. AB - METHODS: A systematic literature review was performed using MEDLINE, Web of Science, Embase, and Cochrane Library for studies published between 2000 and January of 2015. Random-effects meta-analysis was used to estimate the overall pooled incidence of seroma and to examine the effect of drain number and acellular dermal matrix use. AB - RESULTS: Seventy-two relevant primary articles and three systematic reviews were identified. Fifty-one citations met inclusion criteria, including two randomized controlled trials. The overall pooled incidence was 5.4 percent (95 percent CI, 4.1 to 6.7 percent). Obesity, acellular dermal matrix, and preoperative irradiation were cited risk factors. Pooled relative risk for acellular dermal matrix was 1.83 (95 percent CI, 1.28 to 2.62). Drain practices were collated from 34 articles. AB - CONCLUSIONS: Seromas following prosthetic breast reconstruction are complicated by the hypovascular, proinflammatory milieu of the mastectomy skin flap, the geometrically complex dead space, and the presence of a foreign body with potential contamination and biofilm. There is reasonable evidence to suggest that these factors contribute to a progression of seroma to infection and prosthesis loss. These findings have motivated this summary article on current practice guidelines and strategies to prevent and treat seromas. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, II. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000481102.24444.72 PT - Journal Article PT - Meta-Analysis PT - Review ID - 10.1097/01.prs.0000481102.24444.72 [doi] ID - 00006534-201604000-00005 [pii] PP - ppublish LG - English DP - 2016 Apr EZ - 2016/03/29 06:00 DA - 2016/08/09 06:00 DT - 2016/03/29 06:00 YR - 2016 ED - 20160808 RD - 20170809 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=27018665 <104. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26868167 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sisti A AU - Grimaldi L AU - Tassinari J AU - Cuomo R AU - Fortezza L AU - Bocchiotti MA AU - Roviello F AU - D'Aniello C AU - Nisi G FA - Sisti, A FA - Grimaldi, L FA - Tassinari, J FA - Cuomo, R FA - Fortezza, L FA - Bocchiotti, M A FA - Roviello, F FA - D'Aniello, C FA - Nisi, G IN - Sisti, A. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. Electronic address: asisti6@gmail.com. IN - Grimaldi, L. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. IN - Tassinari, J. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. IN - Cuomo, R. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. IN - Fortezza, L. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. IN - Bocchiotti, M A. Department of Plastic Surgery, University of Turin, San Giovanni Battista Hospital, Turin, Italy. IN - Roviello, F. Oncologic Surgery, General and Specialist Surgery Department, University of Siena, Siena, Italy. IN - D'Aniello, C. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. IN - Nisi, G. Plastic Surgery Division, General and Specialist Surgery Department, University of Siena, Siena, Italy. TI - Nipple-areola complex reconstruction techniques: A literature review. [Review] SO - European Journal of Surgical Oncology. 42(4):441-65, 2016 Apr AS - Eur J Surg Oncol. 42(4):441-65, 2016 Apr NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 42 IP - 4 PG - 441-65 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - Acellular Dermis MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Nipples/su [Surgery] MH - *Patient Satisfaction MH - *Skin Transplantation/mt [Methods] MH - *Surgical Flaps KW - Local flaps; Nipple-areola reconstruction; Tissue grafts AB - Many techniques for nipple-areola complex (NAC) reconstruction are described. Clarity is required on the currently available options. Since a complete list of all the techniques described until now is not available, a possibly comprehensive literature overview was carried out from 75 papers (years 1946-2015). The local flap was the most frequently described technique for the nipple reconstruction with no significant difference in complications' rate among the various types of techniques. Complications in nipple reconstruction were 46.9% after graft, 7.9% after local flap, and 5.3% in case of flaps with autologous graft/alloplastic/allograft augmentation, while complications in areola reconstruction were 10.1% after graft, and 1.6% after areola tattoo. Flaps appear to be more reliable than grafts in nipple reconstruction, while tattoo is thought to be safer than graft in areola reconstruction. The loss of projection, although considerable (45%-75%), had not significant impact on patients' satisfaction. Due to contraction, overcorrection of 25-50% of the desired result is advisory when adopting local flaps, in order to prevent loss of projection. The use of flaps with autologous graft/alloplastic/allograft augmentation (cartilage, fat, calcium hydroxylapatite, acellular dermal matrix, polymethylmethacrylate, biologic collagen) showed a minor loss of nipple projection but may expose to a relative increased number of postoperative flap necrosis. Copyright © 2016 Elsevier Ltd. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(16)00045-7 DO - https://dx.doi.org/10.1016/j.ejso.2016.01.003 PT - Journal Article PT - Review ID - S0748-7983(16)00045-7 [pii] ID - 10.1016/j.ejso.2016.01.003 [doi] PP - ppublish PH - 2015/09/21 [received] PH - 2015/12/07 [revised] PH - 2016/01/06 [accepted] LG - English EP - 20160130 DP - 2016 Apr EZ - 2016/02/13 06:00 DA - 2016/08/03 06:00 DT - 2016/02/13 06:00 YR - 2016 ED - 20160802 RD - 20160321 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26868167 <105. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27482500 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Klein GM AU - Nasser AE AU - Phillips BT AU - Gersch RP AU - Fourman MS AU - Lilo SE AU - Fritz JR AU - Khan SU AU - Dagum AB AU - Bui DT FA - Klein, Gabriel M FA - Nasser, Ahmed E FA - Phillips, Brett T FA - Gersch, Robert P FA - Fourman, Mitchell S FA - Lilo, Sarit E FA - Fritz, Jason R FA - Khan, Sami U FA - Dagum, Alexander B FA - Bui, Duc T IN - Klein, Gabriel M. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Nasser, Ahmed E. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Phillips, Brett T. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Gersch, Robert P. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Fourman, Mitchell S. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Lilo, Sarit E. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Fritz, Jason R. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Khan, Sami U. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Dagum, Alexander B. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. IN - Bui, Duc T. Division of Plastic Surgery, Department of Surgery, Stony Brook University of Medical Center, Stony Brook, N.Y.; Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham N.C.; Department of Surgery, Hospitals of the University of Pennsylvania, Philadelphia, Pa.; Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa; and The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhassett, N.Y. TI - Is Sterile Better Than Aseptic? Comparing the Microbiology of Acellular Dermal Matrices. SO - Plastic and Reconstructive Surgery - Global Open. 4(6):e761, 2016 Jun AS - Plast. reconstr. surg., Glob. open. 4(6):e761, 2016 Jun NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 6 PG - e761 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956873 CP - United States AB - INTRODUCTION: Postoperative infections are a major complication associated with tissue-expander-based breast reconstruction. The use of acellular dermal matrix (ADM) in this surgery has been identified as a potential reservoir of infection, prompting the development of sterile ADM. Although aseptic and sterile ADMs have been investigated, no study has focused on the occurrence and clinical outcome of bacterial colonization before implantation. AB - METHODS: Samples of aseptic AlloDerm, sterile Ready-To-Use AlloDerm, and AlloMax were taken before implantation. These samples were incubated in Tryptic soy broth overnight before being streaked on Trypticase soy agar, MacConkey agar, and 5% blood agar plates for culture and incubated for 48 hours. Culture results were cross-referenced with patient outcomes for 1 year postoperatively. AB - RESULTS: A total of 92 samples of ADM were collected from 63 patients. There were 15 cases of postoperative surgical site infection (16.3%). Only 1 sample of ADM (AlloMax) showed growth of Escherichia coli, which was likely a result of contamination. That patient did not develop any infectious sequelae. Patient outcomes showed no difference in the incidence of seroma or infection between sterile and aseptic ADMs. AB - CONCLUSIONS: This study evaluates the microbiology of acellular dermal matrices before use in breast reconstruction. No difference was found in the preoperative bacterial load of either aseptic or sterile ADM. No significant difference was noted in infection or seroma formation. Given these results, we believe aseptic processing used on ADMs is equivalent to sterile processing in our patient cohort in terms of clinical infection and seroma occurrence postoperatively. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000705 PT - Journal Article ID - 10.1097/GOX.0000000000000705 [doi] ID - PMC4956873 [pmc] PP - epublish PH - 2016/01/05 [received] PH - 2016/03/09 [accepted] LG - English EP - 20160628 DP - 2016 Jun EZ - 2016/08/03 06:00 DA - 2016/08/03 06:01 DT - 2016/08/03 06:00 YR - 2016 ED - 20160802 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27482500 <106. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27441190 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - DeGeorge BR Jr AU - Campbell CA FA - DeGeorge, Brent R Jr FA - Campbell, Christopher A IN - DeGeorge, Brent R Jr. Department of Plastic and Maxillofacial Surgery, University of Virginia Medical Center, Charlottesville, Virginia, USA. IN - Campbell, Christopher A. Department of Plastic and Maxillofacial Surgery, University of Virginia Medical Center, Charlottesville, Virginia, USA. TI - Techniques to refine the upper outer breast aesthetic subunit in alloplastic breast reconstruction: The lateral capsular flap. SO - Plastic Surgery. 24(2):83-8, 2016 AS - Plast Surg (Oakv). 24(2):83-8, 2016 NJ - Plastic surgery (Oakville, Ont.) VO - 24 IP - 2 PG - 83-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101623618 IO - Plast Surg (Oakv) PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942241 CP - United States KW - Breast aesthetic subunits; Breast surgery; Capsular flap; Lateral breast border AB - BACKGROUND: Lateral displacement of breast implants and axillary fullness are common causes of patient dissatisfaction and reoperation following prosthetic breast reconstruction. Suture plication of the capsule and acellular dermal matrix slings have been described to address lateral implant malposition, but with unacceptably high rates of recurrence and additional cost, respectively. AB - OBJECTIVE: To describe a novel technique using a lateral capsular flap to provide durable correction of implant malposition and, at the same time, redefinition of the lateral breast border, thereby restoring balance to the breast aesthetic subunits. AB - METHODS: Sixteen patients presented with lateral malposition of tissue expanders or breast implants during staged implant-based breast reconstruction, four of whom had additional unwanted axillary soft tissue fullness. An anteriorly based lateral capsular flap was performed for each breast to reconstruct the lateral border of the breast, return the implant to its appropriate position and address axillary fullness when indicated. AB - RESULTS: Lateral capsular flaps were performed for 16 patients (20 breasts) resulting in durable medial repositioning of the implant for a minimum of six months follow-up (range six to 60 months). Eight patients presented after implant placement with subsequent malposition while the remainder presented after tissue expander placement alone. For the eight patients with axillary fullness, elevation of the capsular flap allowed access to axillary contents for excision (four cases) or incorporation of axillary fat into the flap to prevent lateral implant palpability. No major complications, infectious complications or wound healing complications were reported. All patients showed satisfactory results, and reported high cosmetic and functional satisfaction with the appearance of their reconstructed breasts and axillary comfort. AB - CONCLUSIONS: In the authors' experience, the lateral capsular flap represents a simple, safe and reliable technique to correct breast implant lateral malposition, reconstruct the lateral breast border, and address unwanted axillary fullness in primary or revision implant-based breast reconstruction with improved cosmetic appearance and balance of the breast. OA - Publisher: Le deplacement lateral des implants mammaires et de la plenitude axillaire sont des causes courantes d'insatisfaction des patientes et de reoperation apres une reconstruction mammaire prosthetique. La plication de la suture de la capsule et les attelles de la matrice dermique acellulaire corrigent la malposition laterale des implants, mais s'associent a un taux inacceptable de recurrence et a des couts supplementaires, respectivement.; Language: French IS - 2292-5503 IL - 2292-5503 PT - Journal Article ID - PMC4942241 [pmc] PP - ppublish LG - English EP - 20160527 DP - 2016 EZ - 2016/07/22 06:00 DA - 2016/07/22 06:01 DT - 2016/07/22 06:00 YR - 2016 ED - 20160721 RD - 20170601 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27441190 <107. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26910663 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wan D AU - Rohrich RJ FA - Wan, Dinah FA - Rohrich, Rod J IN - Wan, Dinah. Dallas, Texas From the Department of Plastic Surgery, University of Texas Southwestern Medical Center. TI - Revisiting the Management of Capsular Contracture in Breast Augmentation: A Systematic Review. [Review] SO - Plastic & Reconstructive Surgery. 137(3):826-41, 2016 Mar AS - Plast Reconstr Surg. 137(3):826-41, 2016 Mar NJ - Plastic and reconstructive surgery VO - 137 IP - 3 PG - 826-41 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants/ae [Adverse Effects] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - *Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Prosthesis Failure MH - Reoperation/mt [Methods] MH - Risk Assessment MH - *Skin Transplantation/mt [Methods] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - BACKGROUND: Capsular contracture is a complication of breast augmentation that frequently requires revision surgery. "Capsulectomy, site change, and implant exchange" has been referred to as the gold standard treatment of clinically significant contractures. However, the actual clinical evidence behind this algorithm remains elusive at best. A systematic review of the literature was performed to clarify the true evidence behind the surgical management of capsular contracture. AB - METHODS: A search of the MEDLINE database was performed for clinical studies involving the surgical treatment of capsular contracture following breast augmentation. Resulting articles were reviewed using a priori criteria. AB - RESULTS: The systematic review was performed in April of 2015. The primary search for "breast augmentation" yielded 9490 articles. When filtered for "treatment of capsular contracture," 461 articles resulted. Review of these articles and pertinent references using a priori criteria yielded 24 final articles. No controlled trials met final inclusion criteria. AB - CONCLUSIONS: There is limited clinical evidence behind the surgical management of capsular contracture. Site change and implant exchange are associated with reduced contracture recurrence rates and likely play a beneficial role in treating capsular contracture. The data on capsulectomy are less conclusive. Acellular dermal matrix may be a useful adjunct but still requires long-term data. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000480095.23356.ae PT - Journal Article PT - Review ID - 10.1097/01.prs.0000480095.23356.ae [doi] ID - 00006534-201603000-00013 [pii] PP - ppublish LG - English DP - 2016 Mar EZ - 2016/02/26 06:00 DA - 2016/07/07 06:00 DT - 2016/02/25 06:00 YR - 2016 ED - 20160706 RD - 20160225 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26910663 <108. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25462044 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Xie F AU - Nabulyato WM AU - Malata CM FA - Xie, F FA - Nabulyato, W M FA - Malata, C M IN - Xie, F. University of Cambridge School of Clinical Medicine, Cambridge, UK. IN - Nabulyato, W M. Department of Plastic & Reconstructive Surgery at Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Malata, C M. Department of Plastic & Reconstructive Surgery at Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit at Addenbrooke's Hospital, Cambridge, UK; Anglia Ruskin University Postgraduate Medical Institute, Cambridge & Chelmsford, UK. Electronic address: cmalata@hotmail.com. TI - Dermal fat graft from simultaneous abdominoplasty as an adjunct to revision aesthetic and reconstructive breast surgery: A poor man's acellular dermal matrix?. SO - International Journal of Surgery Case Reports. 5(11):829-32, 2014 AS - Int J Surg Case Rep. 5(11):829-32, 2014 NJ - International journal of surgery case reports VO - 5 IP - 11 PG - 829-32 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101529872 IO - Int J Surg Case Rep PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245689 CP - Netherlands KW - Abdominoplasty; Acellular dermal matrix (strattice; Breast implants; Capsulectomy; Dermal fat graft; Health economics; Implant exchange; Periareolar breast implant surgery; Revision breast implant surgery; alloderm) AB - INTRODUCTION: The global use of acellular dermal matrices as an adjunct to tissue expander or implant-based breast reconstruction, by surgeons wishing to cover and support the inferior breast pole, has increased in frequency in the last two decades. However despite the reported enhanced cosmetic outcomes, issues regarding their cost effectiveness have led to their infrequent use within the UK National Health Service and the need for an equally efficacious but cheaper alternative. AB - PRESENTATION OF CASE: We report two patients requiring bilateral revision breast surgery for severely asymmetrical, tender, ptotic breasts and cosmetically poor abdomens. Both were denied assisted acellular dermal matrix reconstructive surgery on the state NHS system and unable to afford the private costs. We therefore utilised free dermal fat grafts, harvested from concomitant abdominoplasties to extend the pectoralis major muscle and smoothen surface irregularities. AB - DISCUSSION: Both patients achieved excellent cosmetic outcomes and aside from a small, spontaneously resolving abdominal site seroma in one patient, have remained free of any complications for over two years. This cost effective procedure is only feasible in patients with an adequate pannus who are amenable to the extra surgery and resultant scarring. AB - CONCLUSION: We herein report the use of free dermal fat graft in revision aesthetic and reconstructive surgery in a manner akin to recent acellular dermal matrix use. The comparable enhanced aesthetic outcomes, minimal complication rate and substantial cost savings merit dissemination to a global audience and encourage surgeons to consider this economic alternative. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved. IS - 2210-2612 IL - 2210-2612 DI - S2210-2612(14)00212-0 DO - https://dx.doi.org/10.1016/j.ijscr.2014.08.026 PT - Journal Article ID - S2210-2612(14)00212-0 [pii] ID - 10.1016/j.ijscr.2014.08.026 [doi] ID - PMC4245689 [pmc] PP - ppublish PH - 2014/07/17 [received] PH - 2014/08/29 [revised] PH - 2014/08/30 [accepted] LG - English EP - 20140916 DP - 2014 EZ - 2014/12/03 06:00 DA - 2014/12/03 06:01 DT - 2014/12/03 06:00 YR - 2014 ED - 20160629 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25462044 <109. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26776905 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Agusti A AU - Ward A AU - Montgomery C AU - Mohammed K AU - Gui GP FA - Agusti, A FA - Ward, A FA - Montgomery, C FA - Mohammed, K FA - Gui, G P H IN - Agusti, A. Academic Surgery (Breast Unit), Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. IN - Ward, A. Academic Surgery (Breast Unit), Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. IN - Montgomery, C. Academic Surgery (Breast Unit), Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. IN - Mohammed, K. Academic Surgery (Breast Unit), Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. IN - Gui, G P H. Academic Surgery (Breast Unit), Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. Electronic address: gerald.gui@rmh.nhs.uk. TI - Aesthetic and oncologic outcomes after one-stage immediate breast reconstruction using a permanent biodimensional expandable implant. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 69(2):211-20, 2016 Feb AS - J Plast Reconstr Aesthet Surg. 69(2):211-20, 2016 Feb NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 69 IP - 2 PG - 211-20 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Adult MH - Aged MH - Breast Neoplasms/di [Diagnosis] MH - Breast Neoplasms/mo [Mortality] MH - *Breast Neoplasms/su [Surgery] MH - *Esthetics MH - Female MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Neoplasm Recurrence, Local/ep [Epidemiology] MH - Neoplasm Staging MH - Prosthesis Design MH - Reoperation MH - Retrospective Studies MH - *Surgical Flaps MH - Survival Rate/td [Trends] MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome MH - United Kingdom/ep [Epidemiology] MH - Young Adult KW - Biodimensional anatomical implants; Cancer recurrence; Expandable implants; Immediate breast reconstruction; One-stage implant reconstruction; Skin-sparing mastectomy AB - INTRODUCTION: Immediate breast reconstruction (IBR) with implants is the commonest method of reconstructive surgery after mastectomy. With careful patient selection, a stable implant pocket can be created at the primary operation to decrease the likelihood of further surgery to adjust the reconstructed side. One-stage IBR is cost effective but failed procedures requiring early revision may be costly as permanent expanders are expensive. AB - METHODS: Data were prospectively collected on all women undergoing a planned one-stage immediate breast reconstruction between 1997 and 2010. All patients had a Style 150 implant (Allergan, Marlow, UK). Descriptive statistics, Kaplan-Meier plots and, where applicable, Cox Proportional Hazards Regression was used to compare outcomes between groups. AB - RESULTS: 249 planned one-stage IBRs were performed in 193 women, median age 45 years (range 20-77) with median follow-up of 101 months (range 27-159 months). 18/193 (9%) patients required implant exchange at 12 months and 66% of patients maintained their original implants at the time of census. Implant assisted latissimus appears to be robust even when radiotherapy was delivered. Disease free survival and breast cancer mortality were as expected for the breast cancer stage treated. AB - CONCLUSION: With careful patient selection, one-stage implant IBR using a definitive anatomical expandable implant provides good long term reconstruction and safe oncologic outcome. Direct to implant decision algorithms may be influenced by future developments in acellular dermal matrix technology, but the ability to create a single-stage stable implant pocket with good surgical technique should not be forgotten. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(15)00450-7 DO - https://dx.doi.org/10.1016/j.bjps.2015.09.017 PT - Journal Article ID - S1748-6815(15)00450-7 [pii] ID - 10.1016/j.bjps.2015.09.017 [doi] PP - ppublish PH - 2014/06/07 [received] PH - 2015/07/07 [revised] PH - 2015/09/27 [accepted] LG - English EP - 20151020 DP - 2016 Feb EZ - 2016/01/19 06:00 DA - 2016/06/22 06:00 DT - 2016/01/19 06:00 YR - 2016 ED - 20160621 RD - 20161126 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26776905 <110. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26723835 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dikmans RE AU - El Morabit F AU - Ottenhof MJ AU - Tuinder SM AU - Twisk JW AU - Moues C AU - Bouman MB AU - Mullender MG FA - Dikmans, R E G FA - El Morabit, F FA - Ottenhof, M J FA - Tuinder, S M H FA - Twisk, J W R FA - Moues, C FA - Bouman, M B FA - Mullender, M G IN - Dikmans, R E G. Department of Plastic, Reconstructive & Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: r.dikmans@vumc.nl. IN - El Morabit, F. Department of Plastic, Reconstructive & Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands. IN - Ottenhof, M J. Department of Plastic, Reconstructive & Hand Surgery, BovenIJ Hospital, Amsterdam, The Netherlands. IN - Tuinder, S M H. Department of Plastic, Reconstructive & Hand Surgery, Maastricht University Medical Center/NUTRIUM, Maastricht, Maastricht, The Netherlands. IN - Twisk, J W R. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. IN - Moues, C. Department of Plastic, Reconstructive & Hand Surgery, Medisch Spectrum Twente, Enschede, The Netherlands. IN - Bouman, M B. Department of Plastic, Reconstructive & Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands. IN - Mullender, M G. Department of Plastic, Reconstructive & Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands. TI - Single-stage breast reconstruction using StratticeTM: A retrospective study. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 69(2):227-33, 2016 Feb AS - J Plast Reconstr Aesthet Surg. 69(2):227-33, 2016 Feb NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 69 IP - 2 PG - 227-33 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Prosthesis Design MH - Reoperation MH - Retrospective Studies MH - Treatment Outcome KW - Acellular dermal matrix; Breast reconstruction; Implant based reconstruction; Single-stage breast reconstruction; Strattice AB - INTRODUCTION: StratticeTM, a porcine acellular dermal matrix, has emerged as a product to augment implant-based breast reconstruction. It aims to resolve problems related to poor tissue coverage of the implant. Presently, evidence justifying the use of Strattice in breast reconstruction is lacking. The objective of this study is to assess the clinical outcomes of a patient cohort that underwent single-stage implant-based breast reconstruction with the additional use of Strattice. AB - METHODS: We conducted a retrospective chart review of patients who underwent single-stage breast reconstruction with the use of Strattice. All cases of breast reconstruction after oncologic or prophylactic mastectomy between 2010 and 2014 in one of eight different centres in the Netherlands were included. Patient demographics, treatment characteristics and clinical outcome data were collected. The outcomes were presented using descriptive statistics, and the associations were evaluated using Fisher's exact test. AB - RESULTS: Eighty-eight patients who underwent either unilateral (60 patients) or bilateral (25 patients) (n = 110 breasts) single-stage breast reconstruction with the use of Strattice were identified. The indication for mastectomy was therapeutic in 69.1% (76) of cases and prophylactic in 30.9% (34) of cases. The reported minor complications included seroma (20.9%), skin necrosis (20.0%), wound dehiscence (11.8%), erythema/inflammation (14.5%) and infection (11.8%). In 22 breasts (22.7%), reoperation was necessary, with explantation of the implant in 11 breasts (11.8%). AB - CONCLUSIONS: In this cohort, the total complication rate was very high (78%). Although most complications were minor, reoperation was performed in 22.7%, with explantation of the implant in 11.8% of breasts. We suggest that patient selection, experience of the surgeon and handling of early complications are factors playing a crucial role in the success of the operation. The use of a Strattice sheet in single-stage implant-based breast reconstruction may be a promising technique, but more evidence from prospective, randomized studies is necessary to justify its use. AB - LEVEL OF EVIDENCE: IV. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(15)00554-9 DO - https://dx.doi.org/10.1016/j.bjps.2015.11.008 PT - Journal Article PT - Multicenter Study ID - S1748-6815(15)00554-9 [pii] ID - 10.1016/j.bjps.2015.11.008 [doi] PP - ppublish PH - 2015/04/02 [received] PH - 2015/11/09 [revised] PH - 2015/11/14 [accepted] LG - English EP - 20151127 DP - 2016 Feb EZ - 2016/01/03 06:00 DA - 2016/06/22 06:00 DT - 2016/01/03 06:00 YR - 2016 ED - 20160621 RD - 20160215 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26723835 <111. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26132336 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Avraham T AU - Weichman KE AU - Wilson S AU - Weinstein A AU - Haddock NT AU - Szpalski C AU - Choi M AU - Karp NS FA - Avraham, Tomer FA - Weichman, Katie E FA - Wilson, Stelios FA - Weinstein, Andrew FA - Haddock, Nicholas T FA - Szpalski, Caroline FA - Choi, Mihye FA - Karp, Nolan S IN - Avraham, Tomer. Institute of Reconstructive Plastic Surgery, New York University, New York, New York. IN - Weichman, Katie E. Institute of Reconstructive Plastic Surgery, New York University, New York, New York. IN - Wilson, Stelios. Institute of Reconstructive Plastic Surgery, New York University, New York, New York. IN - Weinstein, Andrew. Institute of Reconstructive Plastic Surgery, New York University, New York, New York. IN - Haddock, Nicholas T. University of Texas Southwestern, Dallas, Texas. IN - Szpalski, Caroline. Department of Surgery, University Libre de Bruxelles, Brussels, Belgium. IN - Choi, Mihye. Institute of Reconstructive Plastic Surgery, New York University, New York, New York. IN - Karp, Nolan S. Institute of Reconstructive Plastic Surgery, New York University, New York, New York. TI - Postoperative Expansion is not a Primary Cause of Infection in Immediate Breast Reconstruction with Tissue Expanders. SO - Breast Journal. 21(5):501-7, 2015 Sep-Oct AS - Breast J. 21(5):501-7, 2015 Sep-Oct NJ - The breast journal VO - 21 IP - 5 PG - 501-7 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - Adult MH - Biocompatible Materials/ad [Administration & Dosage] MH - *Biocompatible Materials/ae [Adverse Effects] MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Neoplasms/th [Therapy] MH - Female MH - Humans MH - *Mastectomy/ae [Adverse Effects] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Complications MH - *Reconstructive Surgical Procedures/ae [Adverse Effects] MH - Reconstructive Surgical Procedures/mt [Methods] MH - Retrospective Studies MH - *Surgical Wound Infection/et [Etiology] MH - Surgical Wound Infection/pc [Prevention & Control] MH - *Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion/mt [Methods] KW - breast cancer; breast reconstruction; tissue expander AB - Perioperative infection is the most common and dreaded complication associated with tissue expander (TE) breast reconstruction. Historically, the expansion period was thought to be the time of greatest hazard to the implant. However, recent institutional observations suggest infectious complications occur prior to expansion. This investigation, therefore, was conducted to determine the timing of infectious complications associated with two-stage TE breast reconstructions. Following IRB approval, a retrospective review of all consecutive two-stage immediate TE breast reconstructions at a single institution from November 2007 to November 2011 was conducted. Reconstructions were then divided into two cohorts: those suffering infectious complications and those that did not. Infectious complications including minor cellulitis, major cellulitis, abscess drainage, and explantation were identified. Various operative and patient variables were evaluated in comparison. Eight hundred ninety immediate two-stage TE breast reconstructions met inclusion criteria. Patients suffering infection were older (55.4 years versus 49.3 years; p < 0.001), and more likely to have therapeutic mastectomy (94% versus 61%; p < 0.0001), the use of acellular dermal matrix (ADM; 72.5% versus 54.9%; p = 0.001), and greater initial TE fill (448.6 mL versus 404.7 mL; p = 0.0078). The average time to developing of infectious symptoms was 29.6 days (range 9-142 days), with 94.6% (n = 87) of infections prior to the start of expansion. Perioperative infections in immediate two-stage TE to implant breast reconstructions are significant and occur mostly prior to the start of expansion. Thus, challenging the conventional wisdom that instrumentation during expander filling as the primary cause of implant infections. Possible etiologic factors include greater age, therapeutic mastectomy versus prophylactic mastectomy, larger initial TE fill, and the use of ADM. Copyright © 2015 Wiley Periodicals, Inc. RN - 0 (Biocompatible Materials) ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12448 PT - Journal Article ID - 10.1111/tbj.12448 [doi] PP - ppublish LG - English EP - 20150701 DP - 2015 Sep-Oct EZ - 2015/07/02 06:00 DA - 2016/06/09 06:00 DT - 2015/07/02 06:00 YR - 2015 ED - 20160608 RD - 20150903 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26132336 <112. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27190645 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Rose JF AU - Zafar SN AU - Ellsworth Iv WA AI - Rose, Jessica F; ORCID: https://orcid.org/0000-0002-9135-1943 AI - Zafar, Sarosh N; ORCID: https://orcid.org/0000-0002-2213-5980 AI - Ellsworth Iv, Warren A; ORCID: https://orcid.org/0000-0002-8273-3747 FA - Rose, Jessica F FA - Zafar, Sarosh N FA - Ellsworth Iv, Warren A IN - Rose, Jessica F. Division of Plastic Surgery, Department of Surgery, Houston Methodist Hospital, Medical Office Building, 118400 Katy Freeway, Suite 500, Houston, TX 77094, USA. IN - Zafar, Sarosh N. Division of Plastic Surgery, Department of Surgery, Houston Methodist Hospital, Medical Office Building, 118400 Katy Freeway, Suite 500, Houston, TX 77094, USA. IN - Ellsworth Iv, Warren A. Division of Plastic Surgery, Department of Surgery, Houston Methodist Hospital, Medical Office Building, 118400 Katy Freeway, Suite 500, Houston, TX 77094, USA. TI - Does Acellular Dermal Matrix Thickness Affect Complication Rate in Tissue Expander Based Breast Reconstruction?. SO - Plastic Surgery International Print. 2016:2867097, 2016 AS - Plast Surg Int. 2016:2867097, 2016 NJ - Plastic surgery international VO - 2016 PG - 2867097 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101578808 IO - Plast Surg Int PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844898 CP - United States AB - Background. While the benefits of using acellular dermal matrices (ADMs) in breast reconstruction are well described, their use has been associated with additional complications. The purpose of this study was to determine if ADM thickness affects complications in breast reconstruction. Methods. A retrospective chart review was performed including all tissue expander based breast reconstructions with AlloDerm (LifeCell, Branchburg, NJ) over 4 years. We evaluated preoperative characteristics and assessed postoperative complications including seroma, hematoma, infection, skin necrosis, and need for reintervention. We reviewed ADM thickness and time to Jackson-Pratt (JP) drain removal. Results. Fifty-five patients underwent 77 ADM-associated tissue expander based breast reconstructions, with average age of 48.1 years and average BMI of 25.9. Average ADM thickness was 1.21mm. We found higher complication rates in the thick ADM group. Significant associations were found between smokers and skin necrosis (p < 0.0001) and seroma and prolonged JP drainage (p = 0.0004); radiated reconstructed breasts were more likely to suffer infections (p = 0.0085), and elevated BMI is a significant predictor for increased infection rate (p = 0.0037). Conclusion. We found a trend toward increased complication rates with thicker ADMs. In the future, larger prospective studies evaluating thickness may provide more information. IS - 2090-1461 IL - 2090-1461 DO - https://dx.doi.org/10.1155/2016/2867097 PT - Journal Article ID - 10.1155/2016/2867097 [doi] ID - PMC4844898 [pmc] PP - ppublish PH - 2015/12/10 [received] PH - 2016/03/13 [revised] PH - 2016/03/27 [accepted] LG - English EP - 20160412 DP - 2016 EZ - 2016/05/18 06:00 DA - 2016/05/18 06:01 DT - 2016/05/19 06:00 YR - 2016 ED - 20160518 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27190645 <113. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26651226 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Apte A AU - Walsh M AU - Chandrasekharan S AU - Chakravorty A FA - Apte, A FA - Walsh, M FA - Chandrasekharan, S FA - Chakravorty, A IN - Apte, A. Colchester Hospital University NHS Foundation Trust, Colchester General Hospital, Turner Rd, Essex, CO4 5JL, UK. Electronic address: anuapte@gmail.com. IN - Walsh, M. Colchester Hospital University NHS Foundation Trust, Colchester General Hospital, Turner Rd, Essex, CO4 5JL, UK. Electronic address: maia.walsh@hotmail.com. IN - Chandrasekharan, S. Colchester Hospital University NHS Foundation Trust, Colchester General Hospital, Turner Rd, Essex, CO4 5JL, UK. Electronic address: Sekharan.Chandra@colchesterhospital.nhs.uk. IN - Chakravorty, A. Colchester Hospital University NHS Foundation Trust, Colchester General Hospital, Turner Rd, Essex, CO4 5JL, UK. Electronic address: arunmoy.chakravorty@colchesterhospital.nhs.uk. TI - Single-stage immediate breast reconstruction with acellular dermal matrix: Experience gained and lessons learnt from patient reported outcome measures. SO - European Journal of Surgical Oncology. 42(1):39-44, 2016 Jan AS - Eur J Surg Oncol. 42(1):39-44, 2016 Jan NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 42 IP - 1 PG - 39-44 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Esthetics MH - Female MH - Humans MH - Length of Stay MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Pain, Postoperative/pp [Physiopathology] MH - *Patient Outcome Assessment MH - *Patient Satisfaction/sn [Statistics & Numerical Data] MH - Postoperative Care/mt [Methods] MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/th [Therapy] MH - Prospective Studies MH - Risk Assessment MH - Surveys and Questionnaires MH - Tissue Expansion/mt [Methods] MH - Treatment Outcome MH - United Kingdom MH - Wound Healing/ph [Physiology] KW - Acellular dermal matrix; Patient reported outcome measures AB - INTRODUCTION: Acellular Dermal Matrix (ADM) assisted breast reconstruction has transformed the single-stage Immediate Breast Reconstruction (IBR) with an impact on the cosmetic outcomes. However, there is limited data available on patient reported outcomes. This study highlights the Patient Reported Outcome Measures (PROMs), post-operative complications and lessons learnt from ADM assisted single-stage immediate breast reconstruction. AB - METHODS: This prospective study enrolled consecutive patients from Feb 2012 - May 2015 undergoing mastectomy with direct-to-implant ADM assisted breast reconstruction, using StratticeTM (Acelity, San Antonio, TX, USA). Patients were recruited from the beginning of our unit's use of ADMs and completed a post-operative questionnaire at 6 weeks, covering pre-operative, operative and post-operative outcomes. Information on tumour biology and post-operative complications was obtained from the medical notes. AB - RESULTS: This study included 49 patients undergoing a total of 53 procedures. Following surgery 93.3% of women reported a high level of body confidence when clothed. 6.7% of patients reported severe post-operative pain during the first week. Mean length of hospital stay was 1.7 days, return to light activities was within 2.5 weeks and normal activities in 5.4 weeks. Implant loss at 3 months occurred in 5.7% of procedures, of which two thirds were smokers. AB - CONCLUSIONS: PROMs for StratticeTM ADM based reconstruction show high levels of satisfaction with cosmetic outcomes, low incidences of severe post-operative pain and a short recovery process. PROMs help us to better describe patients' experience, allowing women to make more informed choices about ADM based breast reconstruction, which reassures and helps to achieve better outcomes. Copyright © 2015 Elsevier Ltd. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(15)00831-8 DO - https://dx.doi.org/10.1016/j.ejso.2015.10.009 PT - Journal Article ID - S0748-7983(15)00831-8 [pii] ID - 10.1016/j.ejso.2015.10.009 [doi] PP - ppublish PH - 2015/07/24 [received] PH - 2015/09/27 [revised] PH - 2015/10/19 [accepted] LG - English EP - 20151102 DP - 2016 Jan EZ - 2015/12/15 06:00 DA - 2016/05/14 06:00 DT - 2015/12/15 06:00 YR - 2016 ED - 20160513 RD - 20161126 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26651226 <114. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25369836 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bee YS AU - Alonzo B AU - Ng JD FA - Bee, Youn-Shen FA - Alonzo, Brock FA - Ng, John D IN - Bee, Youn-Shen. *Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung; +National Defense Medical Center, Taipei; ++Yuh-Ing Junior College of Health Care and Management, Kaohsiung, Taiwan; Scripps Mercy Hospital, San Diego, California; and ||Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, U.S.A. TI - Review of AlloDerm Acellular Human Dermis Regenerative Tissue Matrix in Multiple Types of Oculofacial Plastic and Reconstructive Surgery. SO - Ophthalmic Plastic & Reconstructive Surgery. 31(5):348-51, 2015 Sep-Oct AS - Ophthal Plast Reconstr Surg. 31(5):348-51, 2015 Sep-Oct NJ - Ophthalmic plastic and reconstructive surgery VO - 31 IP - 5 PG - 348-51 PI - Journal available in: Print PI - Citation processed from: Internet JC - ay2, 8508431 IO - Ophthal Plast Reconstr Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Child MH - Child, Preschool MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Ophthalmologic Surgical Procedures MH - *Reconstructive Surgical Procedures/is [Instrumentation] MH - Retrospective Studies MH - *Skin, Artificial MH - *Surgery, Plastic AB - PURPOSE: AlloDerm acellular human dermis is used for repair or replacement of damaged or inadequate skin tissue. It has been used successfully in multiple types of surgeries, including abdominal wall reconstruction, breast reconstruction, and head and neck reconstruction. Its application to ophthalmic plastic and reconstructive surgery is less well described. This study seeks to evaluate the efficacy and factors influencing surgical outcomes using Alloderm in multiple types of oculofacial plastic surgery. AB - METHODS: Institutional Review Board-approved retrospective review of 84 patients who underwent surgical procedures using Alloderm. Preoperative demographic data, comorbidities, smoking, clinical etiology, surgical methods, Alloderm type, and outcome (cosmetic and functional) were evaluated. AB - RESULTS: This study included 84 patients, accounting for a total of 98 procedures. Mean age was 52.5 years (3-93 years). Etiologies necessitating surgery included malignancy in 26 patients (31.0%), trauma in 19 patients (22.6%), congenital lesions in 15 patients (17.9%), and senile change in 11 patients (13.1%). Surgical procedures included lower eyelid posterior lamella elongation, socket and fornix reconstruction, scar repair, patch grafts, and filler. Mean duration of follow up was 530 days. Overall, 92.8% of patients had favorable outcomes. Factors associated with significantly worse outcomes included smoking, congenital anomaly etiologies, and previous graft/flaps in the same area (p = 0.03, p = 0.029, and p = 0.007, respectively). AB - CONCLUSIONS: This study suggests that Alloderm acellular human dermis can be used safely and effectively in multiple types of oculofacial procedures. Smoking, congenital anomaly etiologies, and previous graft/flap were associated with poor cosmetic and functional outcomes. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1537-2677 IL - 0740-9303 DO - https://dx.doi.org/10.1097/IOP.0000000000000339 PT - Journal Article ID - 10.1097/IOP.0000000000000339 [doi] PP - ppublish LG - English DP - 2015 Sep-Oct EZ - 2014/11/06 06:00 DA - 2016/05/10 06:00 DT - 2014/11/06 06:00 YR - 2015 ED - 20160509 RD - 20150910 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25369836 <115. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26229127 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Deva AK FA - Deva, Anand K IN - Deva, Anand K. Dr Deva is a Co-director of the Surgical Infection Research Group at Macquarie University, Sydney, Australia. TI - Commentary on: Histologic, Molecular, and Clinical Evaluation of Explanted Breast Prostheses, Capsules, and Acellular Dermal Matrices for Bacteria. CM - Comment on: Aesthet Surg J. 2015 Aug;35(6):653-68; PMID: 26229126 SO - Aesthetic Surgery Journal. 35(6):669-71, 2015 Aug AS - Aesthet. surg. j.. 35(6):669-71, 2015 Aug NJ - Aesthetic surgery journal VO - 35 IP - 6 PG - 669-71 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - *Acellular Dermis/ae [Adverse Effects] MH - *Breast Implantation/ae [Adverse Effects] MH - *Breast Implants/ae [Adverse Effects] MH - *Device Removal MH - Female MH - Humans MH - *Implant Capsular Contracture/su [Surgery] MH - *Prosthesis-Related Infections/su [Surgery] ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sjv038 PT - Comment PT - Journal Article ID - sjv038 [pii] ID - 10.1093/asj/sjv038 [doi] PP - ppublish LG - English DP - 2015 Aug EZ - 2015/08/01 06:00 DA - 2016/05/04 06:00 DT - 2015/08/01 06:00 YR - 2015 ED - 20160503 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26229127 <116. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26229126 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Poppler L AU - Cohen J AU - Dolen UC AU - Schriefer AE AU - Tenenbaum MM AU - Deeken C AU - Chole RA AU - Myckatyn TM FA - Poppler, Louis FA - Cohen, Justin FA - Dolen, Utku Can FA - Schriefer, Andrew E FA - Tenenbaum, Marissa M FA - Deeken, Corey FA - Chole, Richard A FA - Myckatyn, Terence M IN - Poppler, Louis. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Cohen, Justin. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Dolen, Utku Can. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Schriefer, Andrew E. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Tenenbaum, Marissa M. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Deeken, Corey. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Chole, Richard A. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. IN - Myckatyn, Terence M. Drs Poppler and Dr Cohen are Residents, Dr Dolen is a Breast Fellow, Dr Tenenbaum is Residency Program Director and Assistant Professor, and Dr Myckatyn is Breast Fellowship Director and Associate Professor, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO. Mr. Schriefer is a Physicist, Genome Technology Access Center, Department of Genetics, Washington University School of Medicine, Saint Louis, MO. Dr Deeken is Director of Biomedical Engineering and Biomaterials Laboratory, Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, MO. and Dr Chole is Lindburg Professor and Chairman, Department of Otolaryngology, and Director of the Biofilm Core Facility, Washington University School of Medicine, Saint Louis, MO. TI - Histologic, Molecular, and Clinical Evaluation of Explanted Breast Prostheses, Capsules, and Acellular Dermal Matrices for Bacteria. CM - Comment in: Aesthet Surg J. 2015 Aug;35(6):669-71; PMID: 26229127 SO - Aesthetic Surgery Journal. 35(6):653-68, 2015 Aug AS - Aesthet. surg. j.. 35(6):653-68, 2015 Aug NJ - Aesthetic surgery journal VO - 35 IP - 6 PG - 653-68 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649701 SB - Index Medicus CP - England MH - *Acellular Dermis/ae [Adverse Effects] MH - Acellular Dermis/mi [Microbiology] MH - Adult MH - Biofilms MH - Biopsy MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/is [Instrumentation] MH - *Breast Implants/ae [Adverse Effects] MH - Breast Implants/mi [Microbiology] MH - Collagen/an [Analysis] MH - *Device Removal MH - Female MH - Humans MH - Implant Capsular Contracture/me [Metabolism] MH - Implant Capsular Contracture/mi [Microbiology] MH - Implant Capsular Contracture/pa [Pathology] MH - *Implant Capsular Contracture/su [Surgery] MH - Microscopy, Confocal MH - Microscopy, Electron, Scanning MH - Microscopy, Fluorescence MH - Middle Aged MH - Predictive Value of Tests MH - Prosthesis-Related Infections/me [Metabolism] MH - Prosthesis-Related Infections/mi [Microbiology] MH - Prosthesis-Related Infections/pa [Pathology] MH - *Prosthesis-Related Infections/su [Surgery] MH - Reoperation MH - Ribotyping MH - Risk Factors MH - Time Factors MH - Tissue Expansion AB - BACKGROUND: Subclinical infections, manifest as biofilms, are considered an important cause of capsular contracture. Acellular dermal matrices (ADMs) are frequently used in revision surgery to prevent recurrent capsular contractures. AB - OBJECTIVE: We sought to identify an association between capsular contracture and biofilm formation on breast prostheses, capsules, and ADMs in a tissue expander/implant (TE/I) exchange clinical paradigm. AB - METHODS: Biopsies of the prosthesis, capsule, and ADM from patients (N = 26) undergoing TE/I exchange for permanent breast implant were evaluated for subclinical infection. Capsular contracture was quantified with Baker Grade and intramammary pressure. Biofilm formation was evaluated with specialized cultures, rtPCR, bacterial taxonomy, live:dead staining, and scanning electron microscopy (SEM). Collagen distribution, capsular histology, and ADM remodeling were quantified following fluorescent and light microscopy. AB - RESULTS: Prosthetic devices were implanted from 91 to 1115 days. Intramammary pressure increased with Baker Grade. Of 26 patients evaluated, one patient had a positive culture and one patient demonstrated convincing evidence of biofilm morphology on SEM. Following PCR amplification 5 samples randomly selected for 16S rRNA gene sequencing demonstrated an abundance of suborder Micrococcineae, consistent with contamination. AB - CONCLUSIONS: Our data suggest that bacterial biofilms likely contribute to a proportion, but not all diagnosed capsular contractures. Biofilm formation does not appear to differ significantly between ADMs or capsules. While capsular contracture remains an incompletely understood but common problem in breast implant surgery, advances in imaging, diagnostic, and molecular techniques can now provide more sophisticated insights into the pathophysiology of capsular contracture. AB - LEVEL OF EVIDENCE: 4 Therapeutic. Copyright © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com. RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sjv017 PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't ID - sjv017 [pii] ID - 10.1093/asj/sjv017 [doi] ID - PMC4649701 [pmc] PP - ppublish GI - No: P30 DC004665 Organization: (DC) *NIDCD NIH HHS* Country: United States GI - No: P30DC04665 Organization: (DC) *NIDCD NIH HHS* Country: United States GI - No: P30 CA91842 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: UL1TR000448 Organization: (TR) *NCATS NIH HHS* Country: United States GI - No: P30 CA091842 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: UL1 TR000448 Organization: (TR) *NCATS NIH HHS* Country: United States LG - English DP - 2015 Aug EZ - 2015/08/01 06:00 DA - 2016/05/03 06:00 DT - 2015/08/01 06:00 YR - 2015 ED - 20160502 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26229126 <117. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26790621 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Zhong T AU - Temple-Oberle C AU - Hofer SO AU - Beber B AU - Semple J AU - Brown M AU - Macadam S AU - Lennox P AU - Panzarella T AU - McCarthy C AU - Baxter N AU - MCCAT Study Group FA - Zhong, Toni FA - Temple-Oberle, Claire FA - Hofer, Stefan O P FA - Beber, Brett FA - Semple, John FA - Brown, Mitchell FA - Macadam, Sheina FA - Lennox, Peter FA - Panzarella, Tony FA - McCarthy, Colleen FA - Baxter, Nancy FA - MCCAT Study Group IN - Zhong, Toni. Division of Plastic and Reconstructive Surgery, University Health Network, Toronto, ON, Canada. toni.zhong@uhn.ca. IN - Temple-Oberle, Claire. Plastic Surgery Oncology, Tom Baker Cancer Centre, Alberta Health Services, Calgary, AB, Canada. Claire.Temple-Oberle@albertahealthservices.ca. IN - Hofer, Stefan O P. Division of Plastic and Reconstructive Surgery, University Health Network, Toronto, ON, Canada. stefan.hofer@uhn.ca. IN - Beber, Brett. Division of Plastic and Reconstructive Surgery, University Health Network, Toronto, ON, Canada. b.beber@utoronto.ca. IN - Semple, John. Division of Plastic and Reconstructive Surgery, University Health Network, Toronto, ON, Canada. john.semple@wchospital.ca. IN - Brown, Mitchell. Division of Plastic and Reconstructive Surgery, University Health Network, Toronto, ON, Canada. Mitchell.brown@wchospital.ca. IN - Macadam, Sheina. Division of Plastic and Reconstructive Surgery, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada. drsmacadam@gmail.com. IN - Lennox, Peter. Division of Plastic and Reconstructive Surgery, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada. klennox@telus.net. IN - Panzarella, Tony. Division of Biostatistics, University Health Network, Toronto, ON, Canada. panzar@uhnresearch.ca. IN - McCarthy, Colleen. Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. McCarthC@mskcc.org. IN - Baxter, Nancy. Department of Surgery, St Michael's Hospital, Toronto, and Keenan Research Centre, Toronto, ON, Canada. BaxterN@smh.ca. TI - Erratum to: The Multi Centre Canadian Acellular Dermal Matrix Trial (MCCAT): study protocol for a randomized controlled trial in implant-based breast reconstruction.[Erratum for Trials. 2013;14:356 Note: Hofer, Stefan [Corrected to Hofer, Stefan O P]; PMID: 24165392] SO - Trials [Electronic Resource]. 17:39, 2016 Jan 20 AS - Trials. 17:39, 2016 Jan 20 NJ - Trials VO - 17 PG - 39 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101263253 IO - Trials PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719656 CP - England ES - 1745-6215 IL - 1745-6215 DO - https://dx.doi.org/10.1186/s13063-016-1179-6 PT - Published Erratum ID - 10.1186/s13063-016-1179-6 [doi] ID - 10.1186/s13063-016-1179-6 [pii] ID - PMC4719656 [pmc] PP - epublish LG - English EP - 20160120 DP - 2016 Jan 20 EZ - 2016/01/23 06:00 DA - 2016/01/23 06:01 DT - 2016/01/22 06:00 YR - 2016 ED - 20160428 RD - 20160124 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26790621 <118. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27058152 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - James J AU - Jackson L AU - Saunders C FA - James, Justin FA - Jackson, Lee FA - Saunders, Christobel IN - James, Justin. Breast Surgery Unit, Fiona Stanley Hospital, 102-118 Murdoch Drive, Murdoch,WA 6150, Australia; Monash University, Faculty of Medicine, Nursing and Health Sciences, VIC 3800, Australia. Electronic address: drjustinjamesj@yahoo.co.uk. IN - Jackson, Lee. Breast Surgery Unit, Fiona Stanley Hospital, 102-118 Murdoch Drive, Murdoch,WA 6150, Australia. Electronic address: lee.jackson@health.wa.gov.au. IN - Saunders, Christobel. Breast Surgery Unit, Fiona Stanley Hospital, 102-118 Murdoch Drive, Murdoch,WA 6150, Australia; University of Western Australia, School of Surgery, Harry Perkins Institute of Medical Research, Fiona Stanley Hospital, Murdoch, WA 6150, Australia. TI - Florid pustular dermatitis of breast: A case report on a unusual complication from acellular dermal matrix use. SO - International Journal of Surgery Case Reports. 22:59-61, 2016 AS - Int J Surg Case Rep. 22:59-61, 2016 NJ - International journal of surgery case reports VO - 22 PG - 59-61 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101529872 IO - Int J Surg Case Rep PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832039 CP - Netherlands KW - Acellular dermal matrix; Case report; Pustular dermatitis; Red breast syndrome AB - INTRODUCTION: Idiopathic erythematous reaction of the breast (Red breast syndrome) is a known complication following breast reconstruction with acellular dermal matrix. However pustular dermatitis like presentation is not previously known. AB - PRESENTATION OF CASE: We present a 42-year-old lady who developed bilateral pustular dermatitis like appearance following breast reconstruction with acellular dermal matrix slings. Though surgical washout was done, both expanders and flex HD could be preserved. AB - DISCUSSION: Acellular dermal matrix use is the only possible explanation for such a presentation and this can be considered a variant of red breast syndrome. AB - CONCLUSION: Pustular dermatitis like presentation can be associated with acelluar dermal matrix use and should be considered in similar clinical presentations, since this can avoid unnecessary surgical procedures. Copyright © 2016. Published by Elsevier Ltd. IS - 2210-2612 IL - 2210-2612 DI - S2210-2612(16)30005-0 DO - https://dx.doi.org/10.1016/j.ijscr.2016.02.040 PT - Journal Article ID - S2210-2612(16)30005-0 [pii] ID - 10.1016/j.ijscr.2016.02.040 [doi] ID - PMC4832039 [pmc] PP - ppublish PH - 2015/11/11 [received] PH - 2016/02/28 [revised] PH - 2016/02/28 [accepted] LG - English EP - 20160304 DP - 2016 EZ - 2016/04/09 06:00 DA - 2016/04/09 06:01 DT - 2016/04/09 06:00 YR - 2016 ED - 20160426 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27058152 <119. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26085227 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - M D AU - J A AU - A S AU - A G AU - T R AU - B G AU - J S FA - M, Dieterich FA - J, Angres FA - A, Stachs FA - A, Glass FA - T, Reimer FA - B, Gerber FA - J, Stubert IN - M, Dieterich. Breast Unit, Department of Obstetrics and Gynecology, Interdisciplinary Breast Center, University of Rostock, Suedring 81, 18059, Rostock, Germany, max.dieterich@uni-rostock.de. TI - Patient-Report Satisfaction and Health-Related Quality of Life in TiLOOP Bra-Assisted or Implant-Based Breast Reconstruction Alone. SO - Aesthetic Plastic Surgery. 39(4):523-33, 2015 Aug AS - Aesthetic Plast Surg. 39(4):523-33, 2015 Aug NJ - Aesthetic plastic surgery VO - 39 IP - 4 PG - 523-33 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adult MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty MH - Middle Aged MH - *Patient Satisfaction MH - Polypropylenes MH - Prosthesis Design MH - *Quality of Life MH - Retrospective Studies MH - *Self Report MH - Surgical Mesh MH - Titanium AB - INTRODUCTION: Implant-based breast reconstructions (IBBR) using alternatives to acellular dermal matrixes are increasing. Data on complications are limited, and information concerning health-related quality of life (HR-QoL) following the use of these synthetic meshes do not exist. AB - METHODS: Between January 2006 and January 2013, patients undergoing immediate or delayed-immediate IBBR with or without titanium covered polypropylene mesh (TiLOOP Bra) were investigated. HR-QoL was assessed using the validated self-reporting BREAST-Q questionnaire. Patient demographics and complications were evaluated retrospectively. Stepwise regression backward elimination analysis was performed to identify influential factors on each BREAST-Q domain. AB - RESULTS: Of the 90 women, 42 had IBBR alone and 48 in combination with TiLOOP Bra. The mean follow-up was 18 months in the TiLOOP Bra and 17.5 months in the implant alone group (p = 0.827). The overall complication rate was 21.1 %, with 14.6 % in the TiLOOP Bra and in 28.6 % in the implant alone group (p = 0.105). Capsular contraction rate was 4.4 % in the TiLOOP Bra and 16.7 % in the implant alone group (p = 0.052). The analysis of the HR-QoL showed no significant differences between the groups. Surgeries prior to IBBR had a positive influence on HR-QoL. TiLOOP Bra was associated with a negative effect on "satisfaction with breast" (beta = -5.72; p < 0.001), as it was no longer observed for "satisfaction with outcome" and other domains. RN - 0 (Polypropylenes) RN - D1JT611TNE (Titanium) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-015-0520-x PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't ID - 10.1007/s00266-015-0520-x [doi] PP - ppublish PH - 2015/02/02 [received] PH - 2015/06/10 [accepted] LG - English EP - 20150618 DP - 2015 Aug EZ - 2015/06/19 06:00 DA - 2016/04/15 06:00 DT - 2015/06/19 06:00 YR - 2015 ED - 20160414 RD - 20150716 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26085227 <120. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25568233 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Leong M AU - Basu CB AU - Hicks MJ FA - Leong, Mimi FA - Basu, C Bob FA - Hicks, M John IN - Leong, Mimi. Dr Leong is a plastic surgeon at Michael E. DeBakey VA Medical Center, and Clinical Assistant Professor of Surgery and Pediatrics, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas. Dr Basu is a plastic surgeon in private practice in Houston, Texas. Dr Hicks is a professor in the Department of Pathology, Baylor College of Medicine, Houston, Texas. IN - Basu, C Bob. Dr Leong is a plastic surgeon at Michael E. DeBakey VA Medical Center, and Clinical Assistant Professor of Surgery and Pediatrics, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas. Dr Basu is a plastic surgeon in private practice in Houston, Texas. Dr Hicks is a professor in the Department of Pathology, Baylor College of Medicine, Houston, Texas. IN - Hicks, M John. Dr Leong is a plastic surgeon at Michael E. DeBakey VA Medical Center, and Clinical Assistant Professor of Surgery and Pediatrics, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas. Dr Basu is a plastic surgeon in private practice in Houston, Texas. Dr Hicks is a professor in the Department of Pathology, Baylor College of Medicine, Houston, Texas. TI - Further evidence that human acellular dermal matrix decreases inflammatory markers of capsule formation in implant-based breast reconstruction. SO - Aesthetic Surgery Journal. 35(1):40-7, 2015 Jan AS - Aesthet. surg. j.. 35(1):40-7, 2015 Jan NJ - Aesthetic surgery journal VO - 35 IP - 1 PG - 40-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Biomarkers/me [Metabolism] MH - Biopsy MH - Breast/im [Immunology] MH - Breast/pa [Pathology] MH - *Breast/su [Surgery] MH - Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Down-Regulation MH - Female MH - Fibrosis MH - Humans MH - Immunohistochemistry MH - Implant Capsular Contracture/im [Immunology] MH - Implant Capsular Contracture/pa [Pathology] MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - *Inflammation Mediators/me [Metabolism] MH - Middle Aged MH - Retrospective Studies MH - Treatment Outcome AB - BACKGROUND: Human acellular dermal matrix (HADM; previously termed "acellular cadaveric dermis") may limit inflammatory changes believed to play a role in capsular contracture, a common complication of implant-based breast reconstruction. AB - OBJECTIVES: Differences between HADM and native breast capsule specimens were evaluated by immunohistochemical analysis of key inflammatory markers involved in capsule formation. AB - METHODS: Twenty consecutive patients underwent immediate, 2-stage, implant-based breast reconstruction with dual-plane HADM. During tissue expander-implant exchange, full-thickness biopsies of biointegrated HADM and native breast capsule (internal control) from the tissue-expander envelope were obtained. Immunohistochemical analysis was performed for endothelial cells (CD31), B cells (CD20), T cells (CD3), macrophages (CD68), collagen I and III, and myofibroblasts (alpha-smooth muscle actin). Observed levels of marker labeling were semiquantitatively scored from 0 (none) to 3 (severe) by a blinded histopathologist and were statistically analyzed with the Wilcoxon rank sum test. AB - RESULTS: A bilateral sample was obtained from 1 patient; all other samples were unilateral. Compared with capsule samples from native breast tissue, HADM samples had significantly lower levels of all inflammatory markers (P < .001). AB - CONCLUSIONS: These lower levels of inflammatory markers support previous evidence that HADM may inhibit inflammatory and profibrotic signaling characteristics of breast capsule development and decrease the risk of capsular contracture. Further investigation is needed to determine the mechanism by which HADM inhibits these inflammatory cells, whether HADM reduces the incidence of breast capsular contracture, and if so, the longevity of this effect. Copyright © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com. RN - 0 (Biomarkers) RN - 0 (Inflammation Mediators) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sju014 PT - Journal Article PT - Observational Study ID - sju014 [pii] ID - 10.1093/asj/sju014 [doi] PP - ppublish LG - English DP - 2015 Jan EZ - 2015/01/09 06:00 DA - 2016/04/15 06:00 DT - 2015/01/09 06:00 YR - 2015 ED - 20160414 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25568233 <121. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25894022 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ibrahim AM AU - Koolen PG AU - Ganor O AU - Markarian MK AU - Tobias AM AU - Lee BT AU - Lin SJ AU - Mureau MA FA - Ibrahim, Ahmed M S FA - Koolen, Pieter G L FA - Ganor, Oren FA - Markarian, Mark K FA - Tobias, Adam M FA - Lee, Bernard T FA - Lin, Samuel J FA - Mureau, Marc A M IN - Ibrahim, Ahmed M S. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, aibrahim@bidmc.harvard.edu. TI - Does acellular dermal matrix really improve aesthetic outcome in tissue expander/implant-based breast reconstruction?. SO - Aesthetic Plastic Surgery. 39(3):359-68, 2015 Jun AS - Aesthetic Plast Surg. 39(3):359-68, 2015 Jun NJ - Aesthetic plastic surgery VO - 39 IP - 3 PG - 359-68 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Chi-Square Distribution MH - Cohort Studies MH - *Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Observer Variation MH - Prosthesis Design MH - Prosthesis Failure MH - Retrospective Studies MH - Risk Assessment MH - Statistics, Nonparametric MH - *Tissue Expansion Devices/ut [Utilization] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - BACKGROUND: The expectation for improved results by women undergoing postmastectomy reconstruction has steadily risen. A majority of these operations are tissue expander/implant-based breast reconstructions. Acellular dermal matrix (ADM) offers numerous advantages in these procedures. Thus far, the evidence to justify improved aesthetic outcome has solely been based on surgeon opinion. The purpose of this study was to assess aesthetic outcome following ADM use in tissue expander/implant-based breast reconstruction by a panel of blinded plastic surgeons. AB - METHODS: Mean aesthetic results of patients who underwent tissue expander/implant-based breast reconstruction with (n = 18) or without ADM (n = 20) were assessed with objective grading of preoperative and postoperative photographs by five independent blinded plastic surgeons. Absolute observed agreement as well as weighted Fleiss Kappa (kappa) test statistics were calculated to assess inter-rater variability. AB - RESULTS: When ADM was incorporated, the overall aesthetic score was improved by an average of 12.1 %. In addition, subscale analyses revealed improvements in breast contour (35.2 %), implant placement (20.7 %), lower pole projection (16.7 %), and inframammary fold definition (13.8 %). Contour (p = 0.039), implant placement (p = 0.021), and overall aesthetic score (p = 0.022) reached statistical significance. Inter-rater reliability showed mostly moderate agreement. AB - CONCLUSIONS: Mean aesthetic scores were higher in the ADM-assisted breast reconstruction cohort including the total aesthetic score which was statistically significant. Aesthetic outcome alone may justify the added expense of incorporating biologic mesh. Moreover, ADM has other benefits which may render it cost-effective. Larger prospective studies are needed to provide plastic surgeons with more definitive guidelines for ADM use. AB - LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-015-0484-x PT - Comparative Study PT - Journal Article ID - 10.1007/s00266-015-0484-x [doi] PP - ppublish PH - 2014/12/24 [received] PH - 2015/03/26 [accepted] LG - English EP - 20150417 DP - 2015 Jun EZ - 2015/04/22 06:00 DA - 2016/04/09 06:00 DT - 2015/04/21 06:00 YR - 2015 ED - 20160408 RD - 20150518 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25894022 <122. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27047784 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Cabalag MS AU - Rostek M AU - Miller GS AU - Chae MP AU - Quinn T AU - Rozen WM AU - Hunter-Smith DJ FA - Cabalag, Miguel S FA - Rostek, Marie FA - Miller, George S FA - Chae, Michael P FA - Quinn, Tam FA - Rozen, Warren M FA - Hunter-Smith, David J IN - Cabalag, Miguel S. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. IN - Rostek, Marie. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. IN - Miller, George S. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. IN - Chae, Michael P. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. IN - Quinn, Tam. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. IN - Rozen, Warren M. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. IN - Hunter-Smith, David J. 1 Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, Frankston, Victoria 3199, Australia ; 2 Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, Frankston, Victoria 3199, Australia ; 3 Department of Surgery, Townsville Hospital, School of Medicine and Dentistry, James Cook University Clinical School, Townsville, Queensland 4814, Australia. TI - Alloplastic adjuncts in breast reconstruction. [Review] SO - Gland Surgery. 5(2):158-73, 2016 Apr AS - Gland surg.. 5(2):158-73, 2016 Apr NJ - Gland surgery VO - 5 IP - 2 PG - 158-73 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791350 CP - China (Republic : 1949- ) KW - Breast reconstruction; acellular dermal matrices (ADMs); alloplastic implants; breast implants AB - BACKGROUND: There has been an increasing role of acellular dermal matrices (ADMs) and synthetic meshes in both single- and two-stage implant/expander breast reconstruction. Numerous alloplastic adjuncts exist, and these vary in material type, processing, storage, surgical preparation, level of sterility, available sizes and cost. However, there is little published data on most, posing a significant challenge to the reconstructive surgeon trying to compare and select the most suitable product. The aims of this systematic review were to identify, summarize and evaluate the outcomes of studies describing the use of alloplastic adjuncts for post-mastectomy breast reconstruction. The secondary aims were to determine their cost-effectiveness and analyze outcomes in patients who also underwent radiotherapy. AB - METHODS: Using the PRSIMA 2009 statement, a systematic review was conducted to find articles reporting on the outcomes on the use of alloplastic adjuncts in post-mastectomy breast reconstruction. Multiple databases were searched independently by three authors (Cabalag MS, Miller GS and Chae MP), including: Ovid MEDLINE (1950 to present), Embase (1980 to 2015), PubMed and Cochrane Database of Systematic Reviews. AB - RESULTS: Current published literature on available alloplastic adjuncts are predominantly centered on ADMs, both allogeneic and xenogeneic, with few outcome studies available for synthetic meshes. Outcomes on the 89 articles, which met the inclusion criteria, were summarized and analyzed. The reported outcomes on alloplastic adjunct-assisted breast reconstruction were varied, with most data available on the use of ADMs, particularly AlloDerm() (LifeCell, Branchburg, New Jersey, USA). The use of ADMs in single-stage direct-to-implant breast reconstruction resulted in lower complication rates (infection, seroma, implant loss and late revision), and was more cost effective when compared to non-ADM, two-stage reconstruction. The majority of studies demonstrated inferior outcomes in ADM assisted, two-stage expander-to-implant reconstruction compared to non-ADM use. Multiple studies suggest that the use of ADMs results in a reduction of capsular contracture rates. Additionally, the reported beneficial effects of ADM use in irradiated tissue were varied. AB - CONCLUSIONS: ADM assisted two-stage breast reconstruction was associated with inferior outcomes when compared to non-ADM use. However, alloplastic adjuncts may have a role in single stage, direct-to-implant breast reconstruction. Published evidence comparing the long-term outcomes between the different types of adjuncts is lacking, and further level one studies are required to identify the ideal product. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2015.06.02 PT - Journal Article PT - Review ID - 10.3978/j.issn.2227-684X.2015.06.02 [doi] ID - gs-05-02-158 [pii] ID - PMC4791350 [pmc] PP - ppublish LG - English DP - 2016 Apr EZ - 2016/04/06 06:00 DA - 2016/04/06 06:01 DT - 2016/04/06 06:00 YR - 2016 ED - 20160406 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27047784 <123. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25911626 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dent BL AU - Cordeiro CN AU - Small K AU - Clemons JA AU - Kessler EG AU - Swistel A AU - Talmor M FA - Dent, Briar L FA - Cordeiro, Christina N FA - Small, Kevin FA - Clemons, Jessica A FA - Kessler, Evan G FA - Swistel, Alexander FA - Talmor, Mia IN - Dent, Briar L. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. IN - Cordeiro, Christina N. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. IN - Small, Kevin. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. IN - Clemons, Jessica A. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. IN - Kessler, Evan G. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. IN - Swistel, Alexander. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. IN - Talmor, Mia. Dr Dent is a Resident and Dr Talmor is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. Dr Cordeiro is a Resident, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr Small is a Fellow, Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Ms. Clemons is a Medical Student, Weill Cornell Medical College, Cornell University, New York, New York. Dr Kessler is a Resident, Department of Surgery, University at Buffalo, Buffalo General Medical Center, Buffalo, New York. Dr Swistel is an Attending Surgeon and Associate Professor of Clinical Surgery, Division of Breast Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. TI - Nipple-Sparing Mastectomy via an Inframammary Fold Incision with Implant-Based Reconstruction in Patients with Prior Cosmetic Breast Surgery. CM - Comment in: Aesthet Surg J. 2015 Jul;35(5):558-60; PMID: 26116743 SO - Aesthetic Surgery Journal. 35(5):548-57, 2015 Jul AS - Aesthet. surg. j.. 35(5):548-57, 2015 Jul NJ - Aesthetic surgery journal VO - 35 IP - 5 PG - 548-57 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Adult MH - Aged MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/is [Instrumentation] MH - *Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty MH - Mastectomy/ae [Adverse Effects] MH - *Mastectomy MH - Middle Aged MH - Nipples/pa [Pathology] MH - *Nipples/su [Surgery] MH - *Organ Sparing Treatments MH - Patient Selection MH - Postoperative Complications/et [Etiology] MH - Retrospective Studies MH - Risk Factors MH - Surgical Flaps MH - Time Factors MH - Treatment Outcome AB - BACKGROUND: Nipple-sparing mastectomy through an inframammary fold incision (NSM-IMF) with implant-based reconstruction (IBR) is a cosmetically preferable approach to breast cancer treatment in appropriate candidates. However, patients who have undergone prior cosmetic breast surgery (CBS) may be at increased risk for postoperative complications secondary to existing surgical scars. AB - OBJECTIVE: To assess whether prior CBS increases the risk of complications following NSM-IMF with IBR. AB - METHODS: A retrospective chart review was conducted for 398 NSM-IMFs with IBR performed between July 2006 and December 2013. CBS cases were identified. Outcomes were reviewed. AB - RESULTS: Of 398 NSM-IMF cases, 41 had prior CBS: 24 augmentations, 12 reductions, three mastopexies, and two augmentation mastopexies. NSM-IMF was performed an average of 8 years following CBS. CBS cases had lower BMIs (P = .040), more breast tissue resected (P = .021), wider breast bases (P = .0002), more single-stage reconstructions (P < .0001), more ADM use (P < .0001), and larger permanent implants (P = .0051) than those without CBS. Postoperatively, CBS cases had higher rates of mastectomy flap ischemia (P = .0392) and hematoma (P = .0335). Among CBS cases, single-stage reconstruction was associated with increased full-thickness flap ischemia (P = .0066). Compared to prior augmentation cases, prior reduction/mastopexy cases had higher rates of capsular contracture (P = .0409) and seroma (P = .0226). AB - CONCLUSIONS: This series is the largest to date to evaluate the success of NSM-IMF with IBR in CBS patients. These women should be cautiously considered for IBR, particularly in the setting of single-stage reconstruction. AB - LEVEL OF EVIDENCE: 4 Therapeutic. Copyright © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com. ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sju158 PT - Journal Article ID - sju158 [pii] ID - 10.1093/asj/sju158 [doi] PP - ppublish PH - 2014/12/03 [accepted] LG - English EP - 20150424 DP - 2015 Jul EZ - 2015/04/26 06:00 DA - 2016/04/05 06:00 DT - 2015/04/26 06:00 YR - 2015 ED - 20160404 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25911626 <124. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25825421 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gabriel A AU - Champaneria MC AU - Maxwell GP FA - Gabriel, Allen FA - Champaneria, Manish C FA - Maxwell, G Patrick IN - Gabriel, Allen. Drs Gabriel and Maxwell are Associate Clinical Professors in the Department of Plastic Surgery at the Loma Linda University Medical Center, Loma Linda, CA. Dr Champaneria is a plastic surgeon in private practice in Vancouver, WA. IN - Champaneria, Manish C. Drs Gabriel and Maxwell are Associate Clinical Professors in the Department of Plastic Surgery at the Loma Linda University Medical Center, Loma Linda, CA. Dr Champaneria is a plastic surgeon in private practice in Vancouver, WA. IN - Maxwell, G Patrick. Drs Gabriel and Maxwell are Associate Clinical Professors in the Department of Plastic Surgery at the Loma Linda University Medical Center, Loma Linda, CA. Dr Champaneria is a plastic surgeon in private practice in Vancouver, WA. TI - The efficacy of botulinum toxin A in post-mastectomy breast reconstruction: a pilot study. SO - Aesthetic Surgery Journal. 35(4):402-9, 2015 May AS - Aesthet. surg. j.. 35(4):402-9, 2015 May NJ - Aesthetic surgery journal VO - 35 IP - 4 PG - 402-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Acellular Dermis MH - Adult MH - *Botulinum Toxins, Type A/ad [Administration & Dosage] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Neuromuscular Agents/ad [Administration & Dosage] MH - Pain Measurement MH - Pain, Postoperative/pc [Prevention & Control] MH - Pilot Projects MH - Prospective Studies MH - Tissue Expansion/mt [Methods] AB - BACKGROUND: Botulinum toxin A has been successfully used in a variety of areas to temporarily obliterate muscle mobility for either functional or aesthetic gain. Tissue expander-based breast reconstruction has been plagued with pain and discomfort. AB - OBJECTIVE: The purpose of this pilot study was to evaluate the role of a neurotoxin (Botulinum toxin A) in expander-based breast reconstruction. AB - METHODS: Thirty patients underwent mastectomies with immediate expander or acellular dermal matrix reconstruction. The neurotoxin group (n = 15) received 40 units of neurotoxin (Botulinum toxin A, Allergan, Inc, Irvine, CA) into each pectoralis major muscle through 4 serial injections and the placebo group (n = 15) received 4 serial injections of 0.9% NaCl. All patients were followed over 1 year, and patient demographics, VAS (visual analog score), laterality, office visits, amount of expansion and number of times to full expansion, and amount of narcotics required were recorded. Statistical significance was considered as p < .05. AB - RESULTS: There were no significant differences between the two groups in terms of age, laterality, expander size, or complications (p = .46-.66). There was a significant difference between the two groups in the VAS score, demonstrating decreased pain in the neurotoxin group (p < .05). In addition, there was a significant increase in the volume of expansion per visit in the neurotoxin group as compared to the placebo group (p < .05). There was no significant difference in narcotic use in the first 3 days after surgery; however, there was a significant decrease in use of narcotics from 7 to 45 days in the neurotoxin group (p < .05). There were no complications associated with the use of the neurotoxin. AB - CONCLUSIONS: The infiltration of the pectoralis major muscle with neurotoxin in immediate, expander-based reconstruction may be beneficial in reducing pain and expediting expansions. Copyright © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com. RN - 0 (Neuromuscular Agents) RN - EC 3-4-24-69 (Botulinum Toxins, Type A) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sjv040 PT - Journal Article PT - Randomized Controlled Trial ID - sjv040 [pii] ID - 10.1093/asj/sjv040 [doi] PP - ppublish PH - 2015/02/24 [accepted] LG - English EP - 20150329 DP - 2015 May EZ - 2015/04/01 06:00 DA - 2016/03/22 06:00 DT - 2015/04/01 06:00 YR - 2015 ED - 20160321 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25825421 <125. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25910026 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cavallo JA AU - Gangopadhyay N AU - Dudas J AU - Roma AA AU - Jasielec MS AU - Baty J AU - Baalman S AU - Frisella MM AU - Tenenbaum MM AU - Myckatyn TM AU - Matthews BD AU - Deeken CR FA - Cavallo, Jaime A FA - Gangopadhyay, Noopur FA - Dudas, Jason FA - Roma, Andres A FA - Jasielec, Mateusz S FA - Baty, Jack FA - Baalman, Sara FA - Frisella, Margaret M FA - Tenenbaum, Marissa M FA - Myckatyn, Terence M FA - Matthews, Brent D FA - Deeken, Corey R IN - Cavallo, Jaime A. From the *Section of Minimally Invasive Surgery, Department of Surgery, +Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO; ++Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH; and Department of Biostatistics, Washington University School of Medicine, St. Louis, MO. TI - Remodeling Characteristics and Collagen Distributions of Biologic Scaffold Materials Biopsied From Postmastectomy Breast Reconstruction Sites. SO - Annals of Plastic Surgery. 75(1):74-83, 2015 Jul AS - Ann Plast Surg. 75(1):74-83, 2015 Jul NJ - Annals of plastic surgery VO - 75 IP - 1 PG - 74-83 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466066 OI - Source: NLM. NIHMS673368 SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - *Biocompatible Materials MH - Biopsy MH - *Breast/pa [Pathology] MH - *Breast/su [Surgery] MH - Collagen/an [Analysis] MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty MH - Mastectomy MH - Middle Aged MH - Prospective Studies MH - *Tissue Scaffolds MH - Young Adult AB - OBJECTIVE: The study purpose was to evaluate the associations between patient characteristics and the histologic remodeling scores of acellular dermal matrices (ADMs) biopsied from breast reconstruction sites in the first attempt to generate a multivariable risk prediction model of nonconstructive remodeling. It was hypothesized that host characteristics and surgical site assessments predict the degree of graft remodeling for ADMs used during breast reconstruction. AB - METHODS: The ADMs were biopsied from the breast reconstruction sites of n = 62 patients during a subsequent breast procedure, stained with hematoxylin-eosin, and evaluated according to a semi-quantitative scoring system for remodeling characteristics (cell types, cell infiltration, extracellular matrix deposition, scaffold degradation, fibrous encapsulation, and neovascularization) and a mean composite score. Biopsies were stained with Sirius Red and Fast Green, and analyzed to determine the collagen I:III ratio. Based on univariate analyses between subject clinical characteristics and the histologic remodeling scores, cohort variables were selected for multivariable regression models using a P value of 0.20 or less. AB - RESULTS: The composite score model yielded 3 variables: pack-year history, corticosteroid use, and radiation timing (r pseudo = 0.81). The model for collagen I yielded 2 variables: corticosteroid use and reason for reoperation (r pseudo = 0.78). The model for collagen III yielded 1 variable: reason for reoperation (r pseudo = 0.35). AB - CONCLUSIONS: These preliminary results constitute the first steps in generating a risk prediction model that predicts the patients and clinical circumstances most likely to experience nonconstructive remodeling of biologic grafts used to reconstruct the breast. RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000538 PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't ID - 10.1097/SAP.0000000000000538 [doi] ID - PMC4466066 [pmc] ID - NIHMS673368 [mid] PP - ppublish GI - No: P30CA091842 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: P30DK052574 Organization: (DK) *NIDDK NIH HHS* Country: United States GI - No: UL1TR000448 Organization: (TR) *NCATS NIH HHS* Country: United States GI - No: P30 CA091842 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: UL1 TR000448 Organization: (TR) *NCATS NIH HHS* Country: United States GI - No: P30 DK052574 Organization: (DK) *NIDDK NIH HHS* Country: United States GI - No: KM1CA156708 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: KM1 CA156708 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2015 Jul EZ - 2015/04/25 06:00 DA - 2016/03/11 06:00 DT - 2015/04/25 06:00 YR - 2015 ED - 20160310 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25910026 <126. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25003412 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Adkinson JM AU - Miller NF AU - Eid SM AU - Miles MG AU - Murphy RX Jr FA - Adkinson, Joshua M FA - Miller, Nathan F FA - Eid, Sherrine M FA - Miles, Marshall G FA - Murphy, Robert X Jr IN - Adkinson, Joshua M. From the *Department of Surgery, Section of Plastic Surgery, University of Michigan Health System, Ann Arbor, MI; and +Department of Surgery, Division of Plastic Surgery, and ++Department of Community Health and Health Studies, Lehigh Valley Health Network, Allentown, PA. TI - Tissue Expander Complications Predict Permanent Implant Complications and Failure of Breast Reconstruction. CM - Comment in: Ann Plast Surg. 2016 Feb;76(2):259; PMID: 26756603 SO - Annals of Plastic Surgery. 75(1):24-8, 2015 Jul AS - Ann Plast Surg. 75(1):24-8, 2015 Jul NJ - Annals of plastic surgery VO - 75 IP - 1 PG - 24-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - Retrospective Studies MH - *Tissue Expansion/ae [Adverse Effects] MH - *Tissue Expansion Devices/ae [Adverse Effects] MH - Treatment Failure AB - BACKGROUND: Two-stage tissue expander-based breast reconstruction is the most commonly used reconstructive modality following mastectomy. We sought to determine if patients who experienced complications during the expansion phase were at increased risk for complications or reconstructive failure after the exchange procedure. AB - METHODS: A retrospective review of tissue expander-based breast reconstructions was performed from January 2007 through December 2011. Variables evaluated included age, presence of cancer, tobacco use, body mass index, comorbidities, use of acellular dermal matrix, chemotherapy, radiation, timing of reconstruction (delayed/immediate), intraoperative tissue expander fill, complications, and explantation or salvage of the reconstruction by means of debridement and closure or myocutaneous flap. AB - RESULTS: A total of 196 patients underwent mastectomy with 304 tissue expander reconstructions. Tobacco use (active and remote), hypertension, and radiation were associated with complications. Patients with a salvaged tissue expander complication were 3 times more likely to have a complication after placement of a permanent implant and 9 times more likely to fail permanent implant reconstruction (ie, require explantation). AB - CONCLUSIONS: Women with complications after placement of a tissue expander are at significantly increased risk for both complications and reconstructive failure after placement of a permanent implant. Consideration for earlier autologous reconstruction as a salvage should be strongly considered in patients with a tissue expander complication, particularly in smokers and those undergoing radiation therapy. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000142 PT - Clinical Study PT - Journal Article ID - 10.1097/SAP.0000000000000142 [doi] PP - ppublish LG - English DP - 2015 Jul EZ - 2014/07/09 06:00 DA - 2016/03/11 06:00 DT - 2014/07/09 06:00 YR - 2015 ED - 20160310 RD - 20160504 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25003412 <127. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23644440 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chauviere MV AU - Schutter RJ AU - Steigelman MB AU - Clark BZ AU - Grayson JK AU - Sahar DE FA - Chauviere, Matthew V FA - Schutter, Ryan J FA - Steigelman, Megan B FA - Clark, Beth Z FA - Grayson, John Kevin FA - Sahar, David E IN - Chauviere, Matthew V. From the *Department of Surgery, +Department of Pathology, and ++Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, CA; and Division of Plastic Surgery, UC Davis School of Medicine, Sacramento, CA. TI - Comparison of AlloDerm and AlloMax tissue incorporation in rats. SO - Annals of Plastic Surgery. 73(3):282-5, 2014 Sep AS - Ann Plast Surg. 73(3):282-5, 2014 Sep NJ - Annals of plastic surgery VO - 73 IP - 3 PG - 282-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - Biocompatible Materials MH - *Collagen MH - Male MH - Rats MH - Rats, Sprague-Dawley AB - BACKGROUND: Human acellular dermal matrices (HADMs) are used in a variety of settings. AlloMax is a new HADM currently being used for breast reconstruction and hernia repair. We compared the in vivo tissue integration of AlloMax to AlloDerm, a well-studied HADM, in rats. AB - METHODS: We implanted AlloDerm and AlloMax patches into subcutaneous pockets on the backs of 32 male Sprague-Dawley rats. The animals were killed after either 4 or 8 weeks, and the patches were recovered and stained for histopathologic analyses. Microscopic end points included patch thickness, vascularization, tissue in-growth, fibroblast proliferation, and inflammation. AB - RESULTS: All animals completed the study without complications or infection. There were no significant differences in graft thicknesses at 4 and 8 weeks. Microscopically, at 4 weeks, AlloDerm sections had significantly more microvessels than AlloMax (P = 0.02). This disparity increased by 8 weeks (P < 0.01). Similarly, we found greater tissue in-growth and fibroblast proliferation in AlloDerm than AlloMax sections at 4 (P < 0.01) and at 8 (P < 0.01) weeks. Inflammatory infiltrates consisted of lymphocytes, histiocytes, eosinophils, and plasma cells. Deep graft infiltration by predominately lymphocytic inflammatory cells was significantly higher in AlloDerm than AlloMax grafts at 4 (P = 0.01) and 8 (P = 0.02) weeks. Graft necrosis was uncommon, but marginal fibrosis was similar in both. AB - CONCLUSIONS: AlloDerm grafts had greater neovascularization, tissue infiltration, fibroblast proliferation, and inflammatory reaction than AlloMax grafts when placed subcutaneously in rats. AlloDerm may be better incorporated than AlloMax when placed in vivo. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31827a2d00 PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. ID - 10.1097/SAP.0b013e31827a2d00 [doi] PP - ppublish LG - English DP - 2014 Sep EZ - 2013/05/07 06:00 DA - 2016/03/11 06:00 DT - 2013/05/07 06:00 YR - 2014 ED - 20160310 RD - 20140815 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=23644440 <128. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26021276 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Duxbury PJ AU - Gandhi A AU - Kirwan CC AU - Jain Y AU - Harvey JR FA - Duxbury, Paula J FA - Gandhi, Ashu FA - Kirwan, Cliona C FA - Jain, Yogesh FA - Harvey, James R IN - Duxbury, Paula J. Manchester Academic Health Science Centre, The University of Manchester, University Hospital of South Manchester, Wythenshawe Hospital, Southmoor Road, M23 9LT, UK Manchester, UK. Electronic address: paula.duxbury@uhsm.nhs.uk. IN - Gandhi, Ashu. Manchester Academic Health Science Centre, The University of Manchester, University Hospital of South Manchester, Wythenshawe Hospital, Southmoor Road, M23 9LT, UK Manchester, UK. IN - Kirwan, Cliona C. Manchester Academic Health Science Centre, The University of Manchester, University Hospital of South Manchester, Wythenshawe Hospital, Southmoor Road, M23 9LT, UK Manchester, UK. IN - Jain, Yogesh. Manchester Academic Health Science Centre, The University of Manchester, University Hospital of South Manchester, Wythenshawe Hospital, Southmoor Road, M23 9LT, UK Manchester, UK. IN - Harvey, James R. Manchester Academic Health Science Centre, The University of Manchester, University Hospital of South Manchester, Wythenshawe Hospital, Southmoor Road, M23 9LT, UK Manchester, UK. TI - Current attitudes to breast reconstruction surgery for women at risk of post-mastectomy radiotherapy: A survey of UK breast surgeons. SO - Breast. 24(4):502-12, 2015 Aug AS - BREAST. 24(4):502-12, 2015 Aug NJ - Breast (Edinburgh, Scotland) VO - 24 IP - 4 PG - 502-12 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9213011 IO - Breast SB - Index Medicus CP - Netherlands MH - *Attitude of Health Personnel MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Clinical Decision-Making MH - Combined Modality Therapy/px [Psychology] MH - Female MH - Humans MH - Male MH - *Mammaplasty/px [Psychology] MH - Mastectomy MH - Patient Selection MH - Radiotherapy, Adjuvant MH - *Surgeons/px [Psychology] MH - Surveys and Questionnaires MH - United Kingdom KW - Breast cancer; Breast reconstruction; Mastectomy; Radiotherapy; Reconstructive surgical procedures AB - Decision-making for women requiring reconstruction and post-mastectomy radiotherapy (PMRT) includes oncological safety, cosmesis, patient choice, potential delay/interference with adjuvant treatment and surgeon/oncologist preference. This study aimed to quantitatively assess surgeons' attitudes and perceptions about reconstructive options in this setting, and to ascertain if surgical volume influenced advice given. A questionnaire was sent to surgical members of the UK Association of Breast Surgery (ABS) in March-June 2014. The questionnaire elicited information on surgeon volume, reconstructive practice and drivers influencing decision-making. Response rate was 42% (148/355), representing 71% of UK breast units. Delayed breast reconstruction (DBR) was offered more commonly than immediate implant, delayed-immediate or immediate autologous reconstruction (p < 0.05). Cosmesis was thought to be equivalent between IBR and DBR by 15% of surgeons, and 26% believe IBR and DBR offer similar Health-related Quality of Life (HRQoL). Surgeon volume had no effect on reconstruction choice. Common decision-making drivers included negative effects of radiotherapy upon reconstructive and cosmetic outcome. The majority of surgeons (77%) believe the current evidence base is insufficient to guide decision-making. Despite surgeons believing that cosmesis and quality of life are not equivalent between IBR and DBR, DBR remains the commonest approach to this difficult clinical scenario. Surgeons perceive they are using a variety of newer techniques such as Delayed-Immediate Reconstruction and Acellular Dermal Matrices to try to ameliorate the effects of PMRT. This survey demonstrates that there is wide variation in reported surgical practice in this difficult setting. There is widespread acknowledgement of the lack of evidence to guide decision-making. Copyright © 2015 Elsevier Ltd. All rights reserved. ES - 1532-3080 IL - 0960-9776 DI - S0960-9776(15)00108-3 DO - https://dx.doi.org/10.1016/j.breast.2015.05.002 PT - Journal Article ID - S0960-9776(15)00108-3 [pii] ID - 10.1016/j.breast.2015.05.002 [doi] PP - ppublish PH - 2015/01/07 [received] PH - 2015/03/24 [revised] PH - 2015/05/03 [accepted] GI - No: NIHR-CS-011-014 Organization: *Department of Health* Country: United Kingdom LG - English EP - 20150526 DP - 2015 Aug EZ - 2015/05/30 06:00 DA - 2016/03/05 06:00 DT - 2015/05/30 06:00 YR - 2015 ED - 20160304 RD - 20170922 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26021276 <129. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23486129 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gaster RS AU - Berger AJ AU - Monica SD AU - Sweeney RT AU - Endress R AU - Lee GK FA - Gaster, Richard S FA - Berger, Aaron J FA - Monica, Stefanie D FA - Sweeney, Robert T FA - Endress, Ryan FA - Lee, Gordon K IN - Gaster, Richard S. From the *Division of Plastic and Reconstructive Surgery, Department of General Surgery, and +Department of Pathology, Stanford University Medical Center, Stanford, CA. TI - Histologic analysis of fetal bovine derived acellular dermal matrix in tissue expander breast reconstruction. SO - Annals of Plastic Surgery. 70(4):447-53, 2013 Apr AS - Ann Plast Surg. 70(4):447-53, 2013 Apr NJ - Annals of plastic surgery VO - 70 IP - 4 PG - 447-53 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Animals MH - Breast Implantation/mt [Methods] MH - *Breast Implantation MH - *Breast Implants MH - Cattle MH - Female MH - Fetus MH - Humans MH - Middle Aged MH - Prospective Studies MH - *Tissue Expansion Devices AB - BACKGROUND: This study seeks to determine human host response to fetal bovine acellular dermal matrix (ADM) in staged implant-based breast reconstruction. AB - METHODS: A prospective study was performed for patients undergoing immediate breast reconstruction with tissue expander placement and SurgiMend acellular fetal bovine dermis. At the time of exchange for permanent implant, we obtained tissue specimens of SurgiMend and native capsule. Histological and immunohistochemical assays were performed to characterize the extent of ADM incorporation/degradation, host cell infiltration, neovascularization, inflammation, and host replacement of acellular fetal bovine collagen. AB - RESULTS: Seventeen capsules from 12 patients were included in our study. The average "implantation" time of SurgiMend was 7.8 months (range, 2-23 months). Histological analysis of the biopsy of tissue revealed rare infiltration of host inflammatory cells, even at 23 months. One patient had an infection requiring removal of the tissue expander at 2 months. Contracture, inflammatory changes, edema, and polymorphonuclear leukocyte infiltration were rare in the ADM. An acellular capsule was seen in many cases, at the interface of SurgiMend with the tissue expander. AB - CONCLUSIONS: SurgiMend demonstrated a very infrequent inflammatory response. An antibody specific to bovine collagen allowed for direct identification of bovine collagen separate from human collagen. Cellular infiltration and neovascularization of SurgiMend correlated with the quality of the mastectomy skin flap rather than the duration of implantation. Future studies are needed to further characterize the molecular mechanisms underlying tissue incorporation of this product. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31827e55af PT - Journal Article ID - 10.1097/SAP.0b013e31827e55af [doi] PP - ppublish LG - English DP - 2013 Apr EZ - 2013/03/15 06:00 DA - 2016/03/05 06:00 DT - 2013/03/15 06:00 YR - 2013 ED - 20160303 RD - 20150610 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23486129 <130. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25942234 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Winocour S AU - Habermann EB AU - Thomsen KM AU - Lemaine V FA - Winocour, Sebastian FA - Habermann, Elizabeth B FA - Thomsen, Kristine M FA - Lemaine, Valerie IN - Winocour, Sebastian. Mayo Clinic, Rochester, MN. TI - Abstract 123: Early Surgical Site Infection Following Tissue Expander Breast Reconstruction With And Without Acellular Dermal Matrix: National Benchmarking Using NSQIP. SO - Plastic & Reconstructive Surgery. 133(3 Suppl):138-9, 2014 Mar AS - Plast Reconstr Surg. 133(3 Suppl):138-9, 2014 Mar NJ - Plastic and reconstructive surgery VO - 133 IP - 3 Suppl PG - 138-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000444949.39099.67 PT - Journal Article ID - 10.1097/01.prs.0000444949.39099.67 [doi] ID - 00006534-201403001-00127 [pii] PP - ppublish LG - English DP - 2014 Mar EZ - 2014/03/01 00:00 DA - 2014/03/01 00:01 DT - 2015/05/06 06:00 YR - 2014 ED - 20160301 RD - 20150506 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25942234 <131. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25942211 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Yu D AU - Hanna K AU - LeGallo R AU - Drake D FA - Yu, Deborah FA - Hanna, Kasandra FA - LeGallo, Robin FA - Drake, David IN - Yu, Deborah. University of Virginia, Charlottesville, VA. TI - Abstract 100: Comparison of the Histological Characteristics of ADM Capsules to No-ADM Breast Capsules in ADM-Assisted Breast Reconstruction. SO - Plastic & Reconstructive Surgery. 133(3 Suppl):113, 2014 Mar AS - Plast Reconstr Surg. 133(3 Suppl):113, 2014 Mar NJ - Plastic and reconstructive surgery VO - 133 IP - 3 Suppl PG - 113 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000444924.68700.50 PT - Journal Article ID - 10.1097/01.prs.0000444924.68700.50 [doi] ID - 00006534-201403001-00104 [pii] PP - ppublish LG - English DP - 2014 Mar EZ - 2014/03/01 00:00 DA - 2014/03/01 00:01 DT - 2015/05/06 06:00 YR - 2014 ED - 20160301 RD - 20150506 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25942211 <132. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25942117 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Mendenhall SD AU - Anderson LA AU - Ying J AU - Boucher KM AU - Neumayer LA AU - Agarwal JP FA - Mendenhall, Shaun D FA - Anderson, Layla A FA - Ying, Jian FA - Boucher, Kenneth M FA - Neumayer, Leigh A FA - Agarwal, Jayant P IN - Mendenhall, Shaun D. 1Southern Illinois University School of Medicine, Springfield, IL, 2University of Utah School of Medicine, Department of Surgery, Salt Lake City, UT, 3University of Utah School of Medicine, Division of Epidemiology and Biostatistics, Salt Lake City, UT, 4University of Utah School of Medicine, Division of Plastic and Reconstructive Surgery, Salt Lake City, UT. TI - Abstract 6: The BREASTrial: Breast Reconstruction Evaluation of Acellular Dermal Matrix as a Sling Trial, Design and Stage I Outcomes of a Randomized Trial. SO - Plastic & Reconstructive Surgery. 133(3 Suppl):13-4, 2014 Mar AS - Plast Reconstr Surg. 133(3 Suppl):13-4, 2014 Mar NJ - Plastic and reconstructive surgery VO - 133 IP - 3 Suppl PG - 13-4 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000444919.45830.d0 PT - Journal Article ID - 10.1097/01.prs.0000444919.45830.d0 [doi] ID - 00006534-201403001-00010 [pii] PP - ppublish LG - English DP - 2014 Mar EZ - 2014/03/01 00:00 DA - 2014/03/01 00:01 DT - 2015/05/06 06:00 YR - 2014 ED - 20160301 RD - 20150506 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25942117 <133. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26894010 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Vu MM AU - De Oliveira GS Jr AU - Mayer KE AU - Blough JT AU - Kim JY FA - Vu, Michael M FA - De Oliveira, Gildasio S Jr FA - Mayer, Kristen E FA - Blough, Jordan T FA - Kim, John Y S IN - Vu, Michael M. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill. IN - De Oliveira, Gildasio S Jr. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill. IN - Mayer, Kristen E. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill. IN - Blough, Jordan T. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill. IN - Kim, John Y S. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill. TI - A Prospective Study Assessing Complication Rates and Patient-Reported Outcomes in Breast Reconstructions Using a Novel, Deep Dermal Human Acellular Dermal Matrix. SO - Plastic and Reconstructive Surgery - Global Open. 3(12):e585, 2015 Dec AS - Plast. reconstr. surg., Glob. open. 3(12):e585, 2015 Dec NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 12 PG - e585 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727694 CP - United States AB - UNLABELLED: The value proposition of an acellular dermal matrix (ADM) taken from the deep dermis is that the allograft may be more porous, allowing for enhanced integration and revascularization. In turn, this characteristic may attenuate complications related to foreign body reactions, seromas, and infection. However, this is juxtaposed against the potential loss of allograft structural integrity, with subsequent risk of malposition and extrusion. Despite the active use of novel, deep dermal ADMs, the clinical outcomes of this new technology has not been well studied. AB - METHODS: This is a prospective study to evaluate surgical and patient-reported outcomes using a deep dermal ADM, FlexHD Pliable. Surgical outcomes and BREAST-Q patient-reported outcomes were evaluated postoperatively at 2- and 6-month time points. AB - RESULTS: Seventy-two breasts (41 patients) underwent reconstruction. Complication rate was 12.5%, including 2 hematomas and 7 flap necroses. One case of flap necrosis led to reconstructive failure. Notably, there were no cases of infection, seroma, or implant extrusion or malposition. Average BREAST-Q scores were satisfaction with outcome (70.13 +/- 23.87), satisfaction with breasts (58.53 +/- 20.00), psychosocial well being (67.97 +/- 20.93), sexual well being (54.11 +/- 27.72), and physical well being (70.45 +/- 15.44). Two-month postoperative BREAST-Q scores decreased compared with baseline and returned to baseline by 6 months. Postoperative radiation therapy had a negative effect on satisfaction with breasts (P = 0.004) and sexual well being (P = 0.006). AB - CONCLUSIONS: Deep dermal ADM is a novel modification of traditional allograft technology. Use of the deep dermal ADM yielded acceptably low complication rates and satisfactory patient-reported outcomes. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000574 PT - Journal Article ID - 10.1097/GOX.0000000000000574 [doi] ID - PMC4727694 [pmc] PP - epublish PH - 2015/07/31 [received] PH - 2015/11/09 [accepted] GI - No: P30 CA060553 Organization: (CA) *NCI NIH HHS* Country: United States LG - English EP - 20160107 DP - 2015 Dec EZ - 2016/02/20 06:00 DA - 2016/02/20 06:01 DT - 2016/02/20 06:00 YR - 2015 ED - 20160219 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26894010 <134. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26893994 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Palaia DA AU - Arthur KS AU - Cahan AC AU - Rosenberg MH FA - Palaia, David A FA - Arthur, Karen S FA - Cahan, Anthony C FA - Rosenberg, Michael H IN - Palaia, David A. Northern Westchester Surgical Services, Mount Kisco, N.Y.; Northern Westchester Hospital, Mt. Kisco, N.Y. IN - Arthur, Karen S. Northern Westchester Surgical Services, Mount Kisco, N.Y.; Northern Westchester Hospital, Mt. Kisco, N.Y. IN - Cahan, Anthony C. Northern Westchester Surgical Services, Mount Kisco, N.Y.; Northern Westchester Hospital, Mt. Kisco, N.Y. IN - Rosenberg, Michael H. Northern Westchester Surgical Services, Mount Kisco, N.Y.; Northern Westchester Hospital, Mt. Kisco, N.Y. TI - Incidence of Seromas and Infections Using Fenestrated versus Nonfenestrated Acellular Dermal Matrix in Breast Reconstructions. SO - Plastic and Reconstructive Surgery - Global Open. 3(11):e569, 2015 Nov AS - Plast. reconstr. surg., Glob. open. 3(11):e569, 2015 Nov NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 11 PG - e569 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727721 CP - United States AB - BACKGROUND: Acellular dermal matrices (ADMs) provide clinical benefits in breast reconstruction but have been associated with increased postoperative complications, most frequently seromas. Fenestration of the ADM before insertion into the reconstructed breast may reduce the incidence of postoperative complications. In this retrospective analysis, postoperative complications were assessed after breast reconstruction with or without fenestrated ADMs. AB - METHODS: Patients who underwent immediate 2-staged implant breast reconstructions using ADM at a single center were assessed. The number of reconstructed breasts was stratified by ADM fenestration status and ADM type. The incidence of seroma, infection, extrusion, and explantation, and cosmetic score, was compared within the 2 stratified groups. A multivariable regression was performed to identify independent risk factors associated with these complications and aesthetic outcome. AB - RESULTS: In total, data from 450 patients who had 603 breast reconstructions using either AlloDerm or FlexHD demonstrated a significantly higher incidence of seroma with nonfenestrated ADMs (20%) versus fenestrated ADMs (11%; P = 0.0098). Rates of infection and explantation, and cosmetic score, were not influenced by fenestration status. In the multivariable analysis, ADM fenestration remained a significant protective factor for seroma formation. FlexHD also yielded a lower incidence of extrusion (P = 0.0031) and a higher cosmetic score (P = 0.0466) compared with AlloDerm after adjusting for other risk factors. AB - CONCLUSIONS: The results of this study support ADM fenestration for reduction of seroma incidence in breast reconstruction, without affecting cosmetic results. Additionally, the choice of ADM may reduce extrusion incidence and improve aesthetic outcomes. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000559 PT - Journal Article ID - 10.1097/GOX.0000000000000559 [doi] ID - PMC4727721 [pmc] PP - epublish PH - 2015/09/02 [received] PH - 2015/10/09 [accepted] LG - English EP - 20151209 DP - 2015 Nov EZ - 2016/02/20 06:00 DA - 2016/02/20 06:01 DT - 2016/02/20 06:00 YR - 2015 ED - 20160219 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26893994 <135. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26374273 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lee KT AU - Mun GH FA - Lee, Kyeong-Tae FA - Mun, Goo-Hyun IN - Lee, Kyeong-Tae. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea. IN - Mun, Goo-Hyun. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea. TI - Prosthetic breast reconstruction in previously irradiated breasts: A meta-analysis. SO - Journal of Surgical Oncology. 112(5):468-75, 2015 Oct AS - J Surg Oncol. 112(5):468-75, 2015 Oct NJ - Journal of surgical oncology VO - 112 IP - 5 PG - 468-75 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - k79, 0222643 IO - J Surg Oncol SB - Index Medicus CP - United States MH - *Breast Implants MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Postoperative Complications MH - Prognosis MH - *Prosthesis Design MH - Radiotherapy, Adjuvant MH - *Surgical Flaps KW - breast reconstruction; complications; implant; prosthesis; radiation AB - BACKGROUND AND OBJECTIVES: The present review evaluated the impacts of pre-reconstruction radiotherapy on outcome of prosthetic breast reconstruction and compared the safety of prosthetic reconstruction with that of other modalities, including autologous tissue reconstruction and the combination of flap and implant in the setting of pre-reconstruction radiation. AB - METHODS: Studies presenting outcomes of prosthetic breast reconstruction in the setting of pre-reconstruction radiation published in the past 10 years were identified and reviewed. AB - RESULTS: Twenty studies were analyzed. Prosthetic reconstruction in previously irradiated breasts showed significantly increased risks for complications, including reconstruction failure (relative risk, 2.58; 95% confidence interval, 1.86-3.57) than those cases without radiation, regardless of the specific surgical technique used, including one-/two-stage reconstruction, use of an acellular dermal matrix or not, and the timing of the reconstruction (immediate/delayed). Autologous tissue reconstruction and a combination flap and implant showed a 92% and 72% decreased risk of reconstruction failure, respectively, in previously irradiated breasts compared with that of prosthetic reconstruction. AB - CONCLUSIONS: The results suggest that prior irradiation significantly increases the risk of complications in patients undergoing prosthetic reconstruction, and using an autologous flap or combining it with an implant can be considered to reconstruct previously irradiated breasts. Copyright © 2015 Wiley Periodicals, Inc. ES - 1096-9098 IL - 0022-4790 DO - https://dx.doi.org/10.1002/jso.24032 PT - Journal Article PT - Meta-Analysis ID - 10.1002/jso.24032 [doi] PP - ppublish PH - 2015/02/10 [received] PH - 2015/08/19 [accepted] LG - English EP - 20150916 DP - 2015 Oct EZ - 2015/09/17 06:00 DA - 2016/02/18 06:00 DT - 2015/09/17 06:00 YR - 2015 ED - 20160216 RD - 20151027 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26374273 <136. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25003464 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Huston TL AU - Small K AU - Swistel AJ AU - Dent BL AU - Talmor M FA - Huston, Tara L FA - Small, Kevin FA - Swistel, Alexander J FA - Dent, Briar L FA - Talmor, Mia IN - Huston, Tara L. From the *Divisions of Plastic Surgery and +Breast Surgery,Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY. TI - Nipple-sparing mastectomy via an inframammary fold incision for patients with scarring from prior lumpectomy. SO - Annals of Plastic Surgery. 74(6):652-7, 2015 Jun AS - Ann Plast Surg. 74(6):652-7, 2015 Jun NJ - Annals of plastic surgery VO - 74 IP - 6 PG - 652-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Cicatrix/et [Etiology] MH - Female MH - Follow-Up Studies MH - Humans MH - Ischemia/ep [Epidemiology] MH - Ischemia/et [Etiology] MH - *Mastectomy, Segmental/mt [Methods] MH - Middle Aged MH - *Nipples/bs [Blood Supply] MH - Nipples/su [Surgery] MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications MH - Reoperation/mt [Methods] MH - Retrospective Studies AB - BACKGROUND: Nipple-sparing mastectomy (NSM) through an inframammary fold (IMF) incision can provide superior cosmesis and a high level of patient satisfaction. Because of concerns for nipple-areolar complex (NAC) viability using this incision, selection criteria may be limited. Here, we evaluate the impact of scarring from prior lumpectomy on NAC viability. AB - METHODS: A retrospective chart review was conducted on a prospectively collected database at a single institution between July 2006 and October 2012. A total of 318 NSMs through IMF incisions were performed. We compared the incidence of NAC ischemia in 122 NSM cases with prior lumpectomy with 196 NSM cases without prior lumpectomy. All 318 mastectomies were followed by implant-based reconstruction. Clinicopathologic factors analyzed included indications for surgery, technical details, patient demographics, comorbidities, and adjuvant therapy. AB - RESULTS: The overall incidence of NAC ischemia was 20.4% (65/318). Nipple-areolar complex ischemia occurred in 24.6% (30/122) of cases with prior lumpectomy and 17.9% (35/196) of cases without prior lumpectomy (P = 0.1477). Among the 30 ischemic events in the 122 cases with prior lumpectomy, epidermolysis occurred in 20 (16.4%) and necrosis occurred in 10 (8.2%). Two cases (1.6%) required operative debridement. Seven cases (5.7%) were left with areas of residual NAC depigmentation. All other cases completely resolved with conservative management. There was no significant correlation between the incidence of ischemia and surgical indication, tumor staging, age, body mass index, tissue resection volume, sternal notch to nipple distance, prior radiation, single-stage reconstruction, sentinel or axillary lymph node dissection, acellular dermal matrix use, presence of periareolar lumpectomy scars, diabetes, or smoking history. At a mean follow-up of 505 days (range, 7-1504 days), patient satisfaction was excellent. Local recurrence of breast cancer occurred in 3 cases (2.5%), and distant recurrence occurred in 2 cases (1.6%). AB - CONCLUSIONS: Patients with scarring from prior lumpectomy do not have a higher rate of NAC ischemia and may be considered for NSM via an IMF incision. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000004 PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0000000000000004 [doi] PP - ppublish LG - English DP - 2015 Jun EZ - 2014/07/09 06:00 DA - 2016/02/10 06:00 DT - 2014/07/09 06:00 YR - 2015 ED - 20160209 RD - 20150514 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25003464 <137. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25389715 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lynch MP AU - Chung MT AU - Rinker BD FA - Lynch, Michael P FA - Chung, Michael T FA - Rinker, Brian D IN - Lynch, Michael P. From the *Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Kentucky; and +University of Kentucky College of Medicine, Lexington, KY. TI - A Comparison of Dermal Autograft and Acellular Dermal Matrix in Tissue Expander Breast Reconstruction: Long-term Aesthetic Outcomes and Capsular Contracture. SO - Annals of Plastic Surgery. 74 Suppl 4:S214-7, 2015 Jun AS - Ann Plast Surg. 74 Suppl 4:S214-7, 2015 Jun NJ - Annals of plastic surgery VO - 74 Suppl 4 PG - S214-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - *Implant Capsular Contracture/et [Etiology] MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Single-Blind Method MH - *Skin Transplantation MH - *Tissue Expansion MH - Transplantation, Autologous AB - BACKGROUND: The use of acellular dermal matrix (ADM) in tissue expander breast reconstruction has been touted to reduce capsular contracture rates and improve aesthetic outcomes. Autogenous dermal grafts have shown to be a safer and more cost-effective alternative to ADM. The purpose of this study was to compare the capsular contracture rates and long-term aesthetic outcomes of tissue expander breast reconstruction using dermal autografts with ADM-assisted reconstruction. AB - METHODS: Patients undergoing tissue expander breast reconstruction with either ADM or dermal autografts were enrolled. Autografts were harvested from the lower abdomen. The capsular contracture rate was assessed via physical examination using the Baker scale. Standardized patient photographs were scored for aesthetic appearance on a 7-point Likert scale by blinded female observers. The ADM and autograft groups were compared using Student t test. Significance was defined as P < 0.05. AB - RESULTS: Forty-eight patients were enrolled (76 breasts). The average follow-up time for the ADM group was 9.6 months and 9.9 months for the dermal autograft group. Twenty-seven patients received ADM, and 21 patients received dermal autograft. Capsular contracture scores were identical between the 2 groups (mean Baker grade = 1.15, P = 0.55). The average long-term aesthetic outcome score for dermal autograft-assisted breast reconstruction was 3.85, compared to 3.79 for ADM-assisted reconstruction. This difference was not statistically significant (P = 0.87). AB - CONCLUSIONS: In addition to an improved safety profile and lower cost, dermal autograft-assisted tissue expander breast reconstruction affords equivalent aesthetic results and capsular contracture rates, when compared to ADM. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000375 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0000000000000375 [doi] PP - ppublish LG - English DP - 2015 Jun EZ - 2014/11/13 06:00 DA - 2016/02/09 06:00 DT - 2014/11/13 06:00 YR - 2015 ED - 20160208 RD - 20150518 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25389715 <138. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25608912 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wu PS AU - Winocour S AU - Jacobson SR FA - Wu, Peter S FA - Winocour, Sebastian FA - Jacobson, Steven R IN - Wu, Peter S. Division of Plastic and Reconstructive Surgery, Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. TI - Red breast syndrome: a review of available literature. [Review] SO - Aesthetic Plastic Surgery. 39(2):227-30, 2015 Apr AS - Aesthetic Plast Surg. 39(2):227-30, 2015 Apr NJ - Aesthetic plastic surgery VO - 39 IP - 2 PG - 227-30 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Erythema/et [Etiology] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Syndrome AB - UNLABELLED: There is scant literature regarding a recently identified clinical entity termed red breast syndrome. Its clinical presentation has been described as a non-infectious, self-limited erythema of a post-mastectomy breast reconstructed using acellular dermal matrix. Its incidence, risk factors, pathophysiology, clinical course, management, and long-term sequelae are largely unknown. We present a review of the available literature on this phenomenon and highlight some opportunities for further research. AB - LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-014-0444-x PT - Journal Article PT - Review ID - 10.1007/s00266-014-0444-x [doi] PP - ppublish PH - 2014/11/27 [received] PH - 2014/12/20 [accepted] LG - English EP - 20150122 DP - 2015 Apr EZ - 2015/01/23 06:00 DA - 2016/02/05 06:00 DT - 2015/01/23 06:00 YR - 2015 ED - 20160204 RD - 20150311 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25608912 <139. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26816672 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Citron I AU - Dower R AU - Ho-Asjoe M FA - Citron, Isabelle FA - Dower, Rory FA - Ho-Asjoe, Mark IN - Citron, Isabelle. Department of Plastic Surgery, Guy's and St Thomas' Hospital, London, United Kingdom. IN - Dower, Rory. Department of Plastic Surgery, Guy's and St Thomas' Hospital, London, United Kingdom. IN - Ho-Asjoe, Mark. Department of Plastic Surgery, Guy's and St Thomas' Hospital, London, United Kingdom. TI - Protocol for the prevention and management of complications related to ADM implant-based breast reconstructions. [Review] SO - Gms Interdisciplinary Plastic & Reconstructive Surgery Dgpw. 5:Doc06, 2016 AS - GMS, Interdiscip. plast. reconstr. surg. DGPW. 5:Doc06, 2016 NJ - GMS Interdisciplinary plastic and reconstructive surgery DGPW VO - 5 PG - Doc06 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101654993 IO - GMS Interdiscip Plast Reconstr Surg DGPW PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724755 CP - Germany KW - Strattice; acellular dermis; breast reconstruction; complications; implant-based; learning curve AB - Acellular dermal matrix (ADM) implant-based reconstructions have transformed direct-to-implant breast reconstruction (DTI). But like all surgery, it is not deplete of complications such as seroma, infections and wound healing problems. These are cited with varying frequencies in the literature. With increased experience and through a series of measures instituted to minimize complications, we have been able to improve outcomes for our patients. We report our technical refinements for prevention of ADM reconstruction associated complications including patient selection, implant selection, drains, dressing and our post operative antibiotic regime. We also outline our protocol for the management of ADM associated complications including seroma, simple and complex infection and red breast syndrome, such that the sequelae of complications are minimized and patients achieve a better long-term outcome. OA - Publisher: Acellulare Gewebematrix (ADM) wird routinemasig bei implantatbasierten Brustrekonstruktionen verwendet. Wie bei allen operativen Eingriffen kann es zu Komplikationen wie z.B. Seromen, Infektionen und einer gestorten Wundheilung kommen. Die Haufigkeitsangaben in der Literatur sind sehr unterschiedlich. Mit zunehmender Erfahrung und einer Reihe von Masnahmen zur Verringerung der Komplikationsraten konnten die Ergebnisse fur unsere Patientinnen verbessert werden. Eine Pravention ADM-assoziierter Komplikationen beinhaltet die Auswahl geeigneter Patientinnen und Implantate, Drainagen und Wundverbande sowie das postoperative Antibiotika-Regime. Daruberhinaus stellen wir unser Protokoll zur Vorgehensweise bei ADM-assoziierten Komplikationen wie Seromen, einfachen und komplexen Infektionen und dem Syndrom der roten Brust vor, mit dem der Schweregrad verringert und die Langzeitergebnisse verbessert werden.; Language: German IS - 2193-8091 IL - 2193-8091 DO - https://dx.doi.org/10.3205/iprs000085 PT - Journal Article PT - Review ID - 10.3205/iprs000085 [doi] ID - iprs000085 [pii] ID - Doc06 [pii] ID - PMC4724755 [pmc] PP - epublish LG - English EP - 20160121 DP - 2016 EZ - 2016/01/28 06:00 DA - 2016/01/28 06:01 DT - 2016/01/28 06:00 YR - 2016 ED - 20160128 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26816672 <140. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25695440 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lewis P AU - Jewell J AU - Mattison G AU - Gupta S AU - Kim H FA - Lewis, Priya FA - Jewell, James FA - Mattison, Gennaya FA - Gupta, Subhas FA - Kim, Hahns IN - Lewis, Priya. From the Department of Plastic Surgery, Loma Linda University, Loma Linda, CA. TI - Reducing postoperative infections and red breast syndrome in patients with acellular dermal matrix-based breast reconstruction: the relative roles of product sterility and lower body mass index. SO - Annals of Plastic Surgery. 74 Suppl 1:S30-2, 2015 May AS - Ann Plast Surg. 74 Suppl 1:S30-2, 2015 May NJ - Annals of plastic surgery VO - 74 Suppl 1 PG - S30-2 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Bacterial Infections/et [Etiology] MH - *Bacterial Infections/pc [Prevention & Control] MH - Body Mass Index MH - *Breast Diseases/et [Etiology] MH - *Breast Diseases/pc [Prevention & Control] MH - Collagen MH - Female MH - Humans MH - Infertility MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Postoperative Complications/et [Etiology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Syndrome AB - PURPOSE: The use of human acellular dermal matrices (ADM) has become routinely used in implant-based breast surgery. Notwithstanding the many benefits for tissue support, the morbidity associated with its use includes seroma and infection, among other potential complications. Some patients experience a specific complication called red breast syndrome (RBS), which has been linked to ADM use, but its exact etiology remains elusive. In our institution, AlloDerm aseptic regenerative tissue matrix was recently replaced with a ready-to-use sterile version that undergoes terminal sterilization, eliminating the need for rehydration. We want to determine if this change in processing affected complications, including RBS. AB - METHODS: We conducted a retrospective chart review analyzing patients from January 1, 2011, to June 1, 2013, who underwent breast surgery with human ADM. Patients with aseptic AlloDerm were compared to patients with sterile AlloDerm. Data were analyzed using the Fisher exact test. AB - RESULTS: A total of 167 reconstructed breasts from 105 patients met inclusion criteria: 56% (n=93) with aseptic ADM, 44% (n=74) with sterile ADM. When comparing the two, patients had a decrease in overall necrosis, infection, seroma, and RBS with sterile ADM. However, the rates did not reach statistical significance. For example, the incidence of RBS decreased from 7.5% to 2.7% (P=0.301) and seroma decreased from 8.6% to 2.7% (P=0.188). The infection rate proved to be equivocal at 11.8% with aseptic ADM to 10.8% with sterile ADM (P=1.000). The only statistically significant change was a decrease in the total complication rate from 41.9% to 27.0% (P=0.046). The absolute risk reduction for total complications was 14.9% with a number-needed-to-treat of 7. AB - CONCLUSION: According to our study, sterile AlloDerm has a clinically decreased incidence of complications compared to aseptic AlloDerm. Whereas RBS decreased, it was interesting to see that it was not eliminated altogether. This suggests that the etiology may be unrelated to ADM processing and warrants further investigation. Overall, the most notable difference was the statistically significant decrease in the total complication rate. Therefore, the change to sterile AlloDerm seems to be beneficial. Further benefit arises from ease of preparation in the operating room. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000475 PT - Clinical Study PT - Journal Article ID - 10.1097/SAP.0000000000000475 [doi] PP - ppublish LG - English DP - 2015 May EZ - 2015/02/20 06:00 DA - 2016/01/28 06:00 DT - 2015/02/20 06:00 YR - 2015 ED - 20160127 RD - 20150416 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25695440 <141. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26275493 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rodriguez-Unda N AU - Leiva S AU - Cheng HT AU - Seal SM AU - Cooney CM AU - Rosson GD FA - Rodriguez-Unda, Nelson FA - Leiva, Stephanie FA - Cheng, Hsu-Tang FA - Seal, Stella M FA - Cooney, Carisa M FA - Rosson, Gedge D IN - Rodriguez-Unda, Nelson. Department of Plastic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, USA. IN - Leiva, Stephanie. Department of Plastic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, USA. IN - Cheng, Hsu-Tang. Department of Plastic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, USA. IN - Seal, Stella M. William H. Welch Medical Library, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. IN - Cooney, Carisa M. Department of Plastic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, USA. IN - Rosson, Gedge D. Department of Plastic Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD, USA. Electronic address: gedge@jhmi.edu. TI - Low incidence of complications using polyglactin 910 (Vicryl) mesh in breast reconstruction: A systematic review. [Review] SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 68(11):1543-9, 2015 Nov AS - J Plast Reconstr Aesthet Surg. 68(11):1543-9, 2015 Nov NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 68 IP - 11 PG - 1543-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Female MH - Global Health MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - *Polyglactin 910 MH - *Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Prosthesis Design MH - *Surgical Mesh KW - Breast reconstruction; Implant tissue expander; Mastectomy; Systematic review; Vicryl mesh AB - BACKGROUND: Mastectomy and breast reconstruction are essential parts of the treatment of breast cancer. Acellular dermal matrices (ADMs) have been used for the reconstruction of the lower pole due to many advantages; however, its cost is seen as a major drawback in this era of concern for the allocation of health-care funds. Recently, polyglactin 910 (Vicryl; Ethicon, Somerville, NJ, USA) mesh has been published as an alternative. We assessed the published literature, in particular investigating for studies that compare Vicryl mesh with ADM. AB - METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Searched databases included Medline/PubMed, Cochrane Reviews, Embase, Web of Science, ClinicalTrials, and SCOPUS. Search criteria were as follows: (1) reporting of clinical data using Vicryl mesh in breast reconstruction, (2) reporting of original data, and (3) outcome of interest reported. AB - RESULTS: We retrieved 290 de-duplicated articles. After title and abstract screening, we dismissed 258 articles, and thus full text was reviewed for 32 articles; only three retrospective articles met inclusion criteria. The total population included 112 patients and 156 breasts. The reported incidence of complications was as follows: infection 2.6% (confidence interval (CI): 0.7-6.6%), reconstruction failure 3.2% (CI: 1.0-7%), and seroma 1.3% (CI: 0.2-4.6%). A seven- to 12-fold cost difference was reported. Follow-up length ranged from 1.2 to 3.6 years. No studies directly compared Vicryl mesh with ADM. AB - CONCLUSIONS: Although the evidence is limited, polyglactin 910 (Vicryl) mesh for immediate breast reconstruction appears to be a potentially safe, effective, and less expensive alternative to ADM. Prospective studies are needed to further compare mesh with ADM. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 34346-01-5 (Polyglactin 910) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(15)00309-5 DO - https://dx.doi.org/10.1016/j.bjps.2015.06.018 PT - Journal Article PT - Meta-Analysis PT - Review ID - S1748-6815(15)00309-5 [pii] ID - 10.1016/j.bjps.2015.06.018 [doi] PP - ppublish PH - 2015/02/27 [received] PH - 2015/06/06 [revised] PH - 2015/06/20 [accepted] LG - English EP - 20150629 DP - 2015 Nov EZ - 2015/08/16 06:00 DA - 2016/01/27 06:00 DT - 2015/08/16 06:00 YR - 2015 ED - 20160126 RD - 20151027 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26275493 <142. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26713264 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Brunnert KE FA - Brunnert, Klaus E IN - Brunnert, Klaus E. Klinik fur Senologie, Osnabruck, Germany. TI - The micropolyurethane foam-coated Diagon/Gel()4Two implant in aesthetic and reconstructive breast surgery - 3-year results of an ongoing study. SO - Gms Interdisciplinary Plastic & Reconstructive Surgery Dgpw. 4:Doc20, 2015 AS - GMS, Interdiscip. plast. reconstr. surg. DGPW. 4:Doc20, 2015 NJ - GMS Interdisciplinary plastic and reconstructive surgery DGPW VO - 4 PG - Doc20 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101654993 IO - GMS Interdiscip Plast Reconstr Surg DGPW PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686800 CP - Germany KW - Diagon/gel4Two implants; acellular dermal matrices; lipofilling; micropolyurethane foam-coating; synthetic meshes AB - BACKGROUND: Breast implants are worldwide in use since 1962. Initially there were some problems with capsular contracture and the palpability of the rim of the implant. In 1968 this led to the introduction of the micropolyurethane foam-coating and then in 1970 to the first micropolyurethane foam-coated implant by F.A. Ashley. As a result of additional technical refinements in manufacturing this new implant design significantly reduced complications i.e. capsular contracture and implant rotation. AB - METHODS: This study reports a single surgeon's experience with aesthetic and reconstructive breast surgery, in primary and secondary cases with the sole use of micropolyurethane foam-coated Diagon/gel()4Two implants, partly in combination with the additional use of synthetic meshes, acellular dermal matrices and lipofilling. The trial is a prospective, single center cohort study designed to demonstrate the safety and effectiveness of the new implant design in primary and secondary aesthetic and reconstructive breast surgery. The reported data provide an interim report of the implantations performed from November 2010 to December 2013. AB - RESULTS: 90 patients were admitted to the study with 152 implants. The majority of the implants (n=95, 62.5%) were used in reoperative cases for either oncological (n=52, 34.2%) or aesthetic reasons (n=43, 28.3%). The median age of the study cohort was 45 years; the median body mass index was 21; the median observation time is 41 months. There was a very low complication rate, both short term within 6 weeks after the implantation of the silicone gel implant and in the follow up in November 2015. There were no serious complications needing explantation, no capsular fibrosis or implant rotation or rupture so far. There were only 4 minor complications (1.97%). There was 1 local recurrence 4 years after skin and nipple sparing mastectomy. AB - CONCLUSION: The micropolyurethane foam-coated Diagon/gel()4Two implant is a very reliable silicone gel implant filled with two high cross-linked, cohesive and form stable gels. The study demonstrated a very high safety profile of the 4Two implant and its effectiveness in both primary and secondary reoperative aesthetic, oncological and reconstructive breast surgery. The study is ongoing, a longer follow-up will be needed to consolidate the data. OA - Publisher: Hintergrund: Brustimplantate sind weltweit seit 1962 in Gebrauch. Von Beginn an gab es Probleme mit der Kapselfibrose und der Tastbarkeit der Implantatrander. 1968 fuhrte dies zu der Einfuhrung des mikropolyurethanbeschichteten Schaums zur Beschichtung der Implantate. 1970 wurde das erste mikropolyurethanschaumbeschichtete Implantat durch F.A. Ashley vorgestellt. Als Resultat spaterer erganzender technischer Verbesserungen in der Herstellung am neuen Implantatdesign konnte die Komplikationsrate z.B. von Kapselfibrose und Implantatrotation signifikant verringert werden. Methode: Diese Studie berichtet uber die Erfahrung mit dem ausschlieslichen Gebrauch von mikropolyurethanbeschichteten Diagon/Gel4Two-Implantaten fur primare und reoperative Falle in der asthetischen und rekonstruktiven Mammachirurgie, teilweise in Kombination mit dem zusatzlichen Gebrauch synthetischer Netze, azellularer Dermis und Lipofilling. Die Studie ist prospektiv angelegt als Kohortenstudie in einem Zentrum, initiiert um die Sicherheit und Effektivitat dieses neuen Implantatdesigns in der primaren und reoperativen asthetischen und rekonstruktiven Brustchirurgie zu demonstrieren. Die berichteten Ergebnisse stellen einen Zwischenbericht uber Implantateinlagen dar, die von November 2010 bis Dezember 2013 durchgefuhrt wurden.Resultate: 90 Patienten wurden in die Studie aufgenommen, mit der Einlage von 152 Implantaten. Die Mehrheit der Implantate (N=95, 62,5%) wurden in reoperativen Fallen aus entweder onkologischer (N=52, 34,2%) oder asthetischer Indikation (N=43, 28,3%) eingesetzt. Das mediane Alter in der Studienkohorte war 45 Jahre, der mediane Body Mass Index 21; die mediane Beobachtungszeit ist 41 Monate. Die Komplikationsrate war sehr niedrig und zwar sowohl in der unmittelbaren postoperativen Zeit von 6 Wochen nach der Implantation des Silikongelimplantates als auch in der anschliesenden Nachbeobachtungszeit bis November 2015. Es gab keine ernsten Komplikationen, die eine Explantation erforderten, bis zu diesem Zeitpunkt keine Kapselfibrosen oder Implantatrotationen oder Rupturen. Es gab nur 4 geringfugige Komplikationen (1,97%). Ferner 1 lokales Rezidiv 4 Jahre nach einer haut- und mamillensparenden Mastektomie.Zusammenfassung: Das mikropolyurethanbeschichtete Diagon/Gel4Two Implantat ist ein sehr zuverlassiges, Silikongel-gefulltes Implantat mit 2 hochvernetzten, kohasiven und formstabilen Gelen. Die Studie demonstriert ein sehr hohes Sicherheitsprofil des 4Two Implantats und seine Effektivitat sowohl in primarer wie auch reoperativer asthetischer, onkologischer und rekonstruktiver Brustchirurgie. Die Studie wird fortgesetzt, zumal ein langeres Follow-Up benotigt wird, um die Daten zu konsolidieren.; Language: German IS - 2193-8091 IL - 2193-8091 DO - https://dx.doi.org/10.3205/iprs000079 PT - Journal Article ID - 10.3205/iprs000079 [doi] ID - iprs000079 [pii] ID - Doc20 [pii] ID - PMC4686800 [pmc] PP - epublish LG - English EP - 20151221 DP - 2015 EZ - 2015/12/30 06:00 DA - 2015/12/30 06:01 DT - 2015/12/30 06:00 YR - 2015 ED - 20151229 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26713264 <143. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26397243 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wagner DS FA - Wagner, Douglas S IN - Wagner, Douglas S. Akron, Ohio From Northeast Ohio Medical University and Akron Plastic Surgeons, LLC. TI - Discussion: Use of Acellular Dermal Matrix in Postmastectomy Breast Reconstruction: Are All Acellular Dermal Matrices Created Equal?. CM - Comment in: Plast Reconstr Surg. 2016 Jul;138(1):146e-7e; PMID: 27348677 CM - Comment on: Plast Reconstr Surg. 2015 Oct;136(4):647-53; PMID: 26397242 SO - Plastic & Reconstructive Surgery. 136(4):654-6, 2015 Oct AS - Plast Reconstr Surg. 136(4):654-6, 2015 Oct NJ - Plastic and reconstructive surgery VO - 136 IP - 4 PG - 654-6 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - *Collagen MH - Female MH - Humans MH - *Postoperative Complications/et [Etiology] RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001625 PT - Comment PT - Journal Article ID - 10.1097/PRS.0000000000001625 [doi] ID - 00006534-201510000-00005 [pii] PP - ppublish LG - English DP - 2015 Oct EZ - 2015/09/24 06:00 DA - 2015/12/23 06:00 DT - 2015/09/24 06:00 YR - 2015 ED - 20151222 RD - 20171025 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26397243 <144. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26397241 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Aliotta R AU - Gurunluoglu R FA - Aliotta, Rachel FA - Gurunluoglu, Raffi IN - Aliotta, Rachel. Cleveland, Ohio From the Department of Plastic Surgery, Cleveland Clinic. TI - Discussion: Capsular Contracture in Implant-Based Breast Reconstruction: Examining the Role of Acellular Dermal Matrix Fenestrations. CM - Comment on: Plast Reconstr Surg. 2015 Oct;136(4):629-35; PMID: 26090760 SO - Plastic & Reconstructive Surgery. 136(4):636-7, 2015 Oct AS - Plast Reconstr Surg. 136(4):636-7, 2015 Oct NJ - Plastic and reconstructive surgery VO - 136 IP - 4 PG - 636-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Implant Capsular Contracture/pc [Prevention & Control] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001627 PT - Comment PT - Journal Article ID - 10.1097/PRS.0000000000001627 [doi] ID - 00006534-201510000-00002 [pii] PP - ppublish LG - English DP - 2015 Oct EZ - 2015/09/24 06:00 DA - 2015/12/23 06:00 DT - 2015/09/24 06:00 YR - 2015 ED - 20151222 RD - 20150924 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26397241 <145. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26397242 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ranganathan K AU - Santosa KB AU - Lyons DA AU - Mand S AU - Xin M AU - Kidwell K AU - Brown DL AU - Wilkins EG AU - Momoh AO FA - Ranganathan, Kavitha FA - Santosa, Katherine B FA - Lyons, Daniel A FA - Mand, Simanjit FA - Xin, Minqiang FA - Kidwell, Kelley FA - Brown, David L FA - Wilkins, Edwin G FA - Momoh, Adeyiza O IN - Ranganathan, Kavitha. Ann Arbor, Mich. From the Section of Plastic Surgery, Department of Surgery, Department of Biostatistics, University of Michigan Health System, and the University of Michigan Medical School. TI - Use of Acellular Dermal Matrix in Postmastectomy Breast Reconstruction: Are All Acellular Dermal Matrices Created Equal?. CM - Comment in: Plast Reconstr Surg. 2015 Oct;136(4):654-6; PMID: 26397243 CM - Comment in: Plast Reconstr Surg. 2016 Jul;138(1):148e-9e; PMID: 27351473 SO - Plastic & Reconstructive Surgery. 136(4):647-53, 2015 Oct AS - Plast Reconstr Surg. 136(4):647-53, 2015 Oct NJ - Plastic and reconstructive surgery VO - 136 IP - 4 PG - 647-53 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - Logistic Models MH - Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/et [Etiology] MH - Surgical Wound Infection/pc [Prevention & Control] AB - BACKGROUND: AlloDerm and FlexHD are two types of acellular dermal matrices commonly used in implant-based reconstruction. Although the use of acellular dermal matrix has revolutionized immediate breast reconstruction in the setting of breast cancer, it remains unclear which type of acellular dermal matrix is best. The purpose of this retrospective cohort study was to compare postoperative complication rates between these two types of acellular dermal matrix. AB - METHODS: The authors reviewed the records of all patients who underwent implant-based breast reconstruction at their institution between 1998 and 2013. Dependent variables of seroma, hematoma, infection, delayed wound healing, implant exposure, and return to the operating room for management of complications were recorded. AB - RESULTS: A total of 309 consecutive patients were identified. Of these, AlloDerm was used in 123 patients (39.8 percent) and FlexHD was used in 186 patients (60.2 percent). Most patients in the authors' cohort underwent immediate reconstruction [n = 288 (93.2 percent)], with a mean follow-up of 20.0 months. Patients receiving AlloDerm were half as likely to have major infections compared with patients receiving FlexHD (OR, 0.50; 95 percent CI, 0.16 to 1.00; p < 0.05). The rates of other complications were similar between the two groups. AB - CONCLUSION: There are significantly increased odds of a major infection in patients who undergo implant-based breast reconstruction using FlexHD compared with AlloDerm. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001569 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/PRS.0000000000001569 [doi] ID - 00006534-201510000-00004 [pii] PP - ppublish LG - English DP - 2015 Oct EZ - 2015/09/24 06:00 DA - 2015/12/22 06:00 DT - 2015/09/24 06:00 YR - 2015 ED - 20151221 RD - 20170707 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26397242 <146. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26090760 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mowlds DS AU - Salibian AA AU - Scholz T AU - Paydar KZ AU - Wirth GA FA - Mowlds, Donald S FA - Salibian, Ara A FA - Scholz, Thomas FA - Paydar, Keyianoosh Z FA - Wirth, Garrett A IN - Mowlds, Donald S. Orange, Calif. From the Department of Plastic Surgery, University of California, Irvine. TI - Capsular Contracture in Implant-Based Breast Reconstruction: Examining the Role of Acellular Dermal Matrix Fenestrations. CM - Comment in: Plast Reconstr Surg. 2015 Oct;136(4):636-7; PMID: 26397241 SO - Plastic & Reconstructive Surgery. 136(4):629-35, 2015 Oct AS - Plast Reconstr Surg. 136(4):629-35, 2015 Oct NJ - Plastic and reconstructive surgery VO - 136 IP - 4 PG - 629-35 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Female MH - Follow-Up Studies MH - Humans MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - Mastectomy MH - Middle Aged MH - Retrospective Studies MH - Silicone Gels MH - Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Acellular dermal matrices have been proposed to decrease the incidence of capsular contracture in implant-based breast reconstructions. The authors have modified acellular dermal matrices with fenestrations to facilitate greater lower pole expansion and improve contour. The effect of fenestrations on the ability of matrices to suppress capsule formation, however, has not been examined. AB - METHODS: A retrospective review of all fenestrated acellular dermal matrix-assisted, implant-based breast reconstructions performed by the two senior authors, with a minimum of 1-year follow-up after permanent implant placement, was completed. Patient demographics, details of extirpative and reconstructive procedures, and complications were examined. Capsular contractures were scored according to the Baker grading scale and compared to those reported in the literature. AB - RESULTS: Thirty patients (50 breasts) underwent fenestrated acellular dermal matrix-assisted reconstruction, with mean follow-up times of 3.3 and 2.6 years after expander placement and implant exchange, respectively. Seven patients (23 percent) had a body mass index greater than 30 kg/m, three (10 percent) were active smokers, and six breasts (12 percent) were irradiated. Complications included one infection (2 percent), six cases (12 percent) of incisional superficial skin necrosis, and one (2 percent) tissue expander extrusion. Zero breasts had clinically significant Baker grade III/IV capsular contracture. The average Baker grade was 1.1. AB - CONCLUSIONS: Fenestrated acellular dermal matrices decrease capsular contracture to rates similar to what is seen with nonfenestrated matrices. Further research is necessary to determine whether this observation is a result of decreased need for inferolateral acellular dermal matrix coverage to achieve these effects or modified physical interaction of acellular dermal matrices with surrounding soft tissues. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 0 (Silicone Gels) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001570 PT - Evaluation Studies PT - Journal Article PT - Video-Audio Media ID - 10.1097/PRS.0000000000001570 [doi] PP - ppublish LG - English DP - 2015 Oct EZ - 2015/06/20 06:00 DA - 2015/12/22 06:00 DT - 2015/06/20 06:00 YR - 2015 ED - 20151221 RD - 20150924 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26090760 <147. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25300607 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hille-Betz U AU - Kniebusch N AU - Wojcinski S AU - Henseler H AU - Heyl V AU - Ohlinger R AU - Paepke S AU - Klapdor R AU - Krause-Bergmann B FA - Hille-Betz, U FA - Kniebusch, N FA - Wojcinski, S FA - Henseler, H FA - Heyl, V FA - Ohlinger, R FA - Paepke, S FA - Klapdor, R FA - Krause-Bergmann, B IN - Hille-Betz, U. Frauenklinik/Brustzentrum der Medizinischen Hochschule Hannover, Hannover, Germany, hille-betz.ursula@mh-hannover.de. TI - Breast reconstruction and revision surgery for implant-associated breast deformities using porcine acellular dermal matrix: a multicenter study of 156 cases. SO - Annals of Surgical Oncology. 22(4):1146-52, 2015 Apr AS - Ann Surg Oncol. 22(4):1146-52, 2015 Apr NJ - Annals of surgical oncology VO - 22 IP - 4 PG - 1146-52 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - b9r, 9420840 IO - Ann. Surg. Oncol. SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - *Breast Implants/ae [Adverse Effects] MH - *Breast Neoplasms/su [Surgery] MH - Cattle MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty MH - Middle Aged MH - Neoplasm Staging MH - *Postoperative Complications MH - Prognosis MH - *Reoperation MH - Retrospective Studies MH - Seroma/et [Etiology] MH - Swine AB - BACKGROUND: Acellular dermal matrix is increasingly used as caudolateral coverage for breast implants in immediate breast reconstruction after skin-sparing mastectomy or in the correction of implant-associated breast deformities. Matrices of human, bovine, and porcine origin are available. The purpose of this retrospective multicenter study was to report experiences with porcine acellular dermal matrices, as only limited data can be found in the literature. AB - METHODS: In the hospital databases of five institutions, 127 patients were identified who underwent breast reconstructions in 156 breasts using an acellular porcine dermal matrix. Medical records were reviewed. Patients were divided into three groups: immediate expander-implant or direct to implant reconstructions (n = 98), delayed expander-implant reconstructions (n = 14), and revision surgery for implant-associated breast deformities (n = 44). AB - RESULTS: With a mean follow-up of 19.6 months, total major complication rate was 7.1 %: implant loss (3.2 %), skin flap necrosis (2.6 %), delayed skin healing (2.6 %), hematoma (1.9 %), seroma (1.3 %), infection (0.6 %), and capsular contracture (0.6 %). Total minor complication rate was 22.9 %, with seroma being the most frequent complication (19.2 %). In the group of immediate breast reconstructions, 20.4 % of the breasts had received radiotherapy in the past. These patients exhibited a significantly higher rate of seroma than patients without prior radiotherapy (35.0 vs. 14.9 %, p = 0.031). AB - CONCLUSIONS: Complication rates using porcine acellular dermal matrix in breast reconstruction are comparable to complication rates reported in studies using human acellular dermal matrices. Thus, porcine acellular dermal matrices can safely be applied in breast reconstructive surgery. ES - 1534-4681 IL - 1068-9265 DO - https://dx.doi.org/10.1245/s10434-014-4098-3 PT - Journal Article PT - Multicenter Study ID - 10.1245/s10434-014-4098-3 [doi] PP - ppublish PH - 2014/05/16 [received] LG - English EP - 20141010 DP - 2015 Apr EZ - 2014/10/11 06:00 DA - 2015/12/17 06:00 DT - 2014/10/11 06:00 YR - 2015 ED - 20151215 RD - 20150302 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25300607 <148. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25818416 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kyle DJ AU - Oikonomou A AU - Hill E AU - Bayat A FA - Kyle, Daniel J T FA - Oikonomou, Antonios FA - Hill, Ernie FA - Bayat, Ardeshir IN - Kyle, Daniel J T. Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK; School of Computer Science, Centre for Mesoscience and Nanotechnology, The University of Manchester, Manchester, UK. IN - Oikonomou, Antonios. School of Computer Science, Centre for Mesoscience and Nanotechnology, The University of Manchester, Manchester, UK. IN - Hill, Ernie. School of Computer Science, Centre for Mesoscience and Nanotechnology, The University of Manchester, Manchester, UK. IN - Bayat, Ardeshir. Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. Electronic address: Ardeshir.Bayat@manchester.ac.uk. TI - Development and functional evaluation of biomimetic silicone surfaces with hierarchical micro/nano-topographical features demonstrates favourable in vitro foreign body response of breast-derived fibroblasts. SO - Biomaterials. 52:88-102, 2015 Jun AS - Biomaterials. 52:88-102, 2015 Jun NJ - Biomaterials VO - 52 PG - 88-102 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - a4p, 8100316 IO - Biomaterials SB - Index Medicus CP - Netherlands MH - Adult MH - *Biomimetic Materials/ch [Chemistry] MH - Biomimetics/mt [Methods] MH - *Breast/cy [Cytology] MH - Breast/im [Immunology] MH - *Breast Implants/ae [Adverse Effects] MH - Cell Adhesion MH - Cells, Cultured MH - *Dimethylpolysiloxanes/ch [Chemistry] MH - Female MH - *Fibroblasts/cy [Cytology] MH - Fibroblasts/im [Immunology] MH - *Foreign-Body Reaction/et [Etiology] MH - Foreign-Body Reaction/im [Immunology] MH - Humans MH - Inflammation/et [Etiology] MH - Inflammation/im [Immunology] MH - Middle Aged MH - Silicones/ch [Chemistry] MH - Surface Properties KW - Acellular dermal matrix (ADM); Biomimetic topography; Capsular contracture; Cell-implant interface; Micro and nano patterning; Silicone breast implant AB - Reproducing extracellular matrix topographical cues, such as those present within acellular dermal matrix (ADM), in synthetic implant surfaces, may augment cellular responses, independent of surface chemistry. This could lead to enhanced implant integration and performance while reducing complications. In this work, the hierarchical micro and nanoscale features of ADM were accurately and reproducibly replicated in polydimethylsiloxane (PDMS), using an innovative maskless 3D grayscale fabrication process not previously reported. Human breast derived fibroblasts (n=5) were cultured on PDMS surfaces and compared to commercially available smooth and textured silicone implant surfaces, for up to one week. Cell attachment, proliferation and cytotoxicity, in addition to immunofluorescence staining, SEM imaging, qRT-PCR and cytokine array were performed. ADM PDMS surfaces promoted cell adhesion, proliferation and survival (p=<0.05), in addition to increased focal contact formation and spread fibroblast morphology when compared to commercially available implant surfaces. PCNA, vinculin and collagen 1 were up-regulated in fibroblasts on biomimetic surfaces while IL8, TNFalpha, TGFbeta1 and HSP60 were down-regulated (p=<0.05). A reduced inflammatory cytokine response was also observed (p=<0.05). This study represents a novel approach to the development of functionalised biomimetic prosthetic implant surfaces which were demonstrated to significantly attenuate the acute in vitro foreign body reaction to silicone. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. RN - 0 (Dimethylpolysiloxanes) RN - 0 (Silicones) RN - 63148-62-9 (baysilon) ES - 1878-5905 IL - 0142-9612 DI - S0142-9612(15)00113-1 DO - https://dx.doi.org/10.1016/j.biomaterials.2015.02.003 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S0142-9612(15)00113-1 [pii] ID - 10.1016/j.biomaterials.2015.02.003 [doi] PP - ppublish PH - 2014/07/31 [received] PH - 2015/01/25 [revised] PH - 2015/02/01 [accepted] LG - English EP - 20150221 DP - 2015 Jun EZ - 2015/03/31 06:00 DA - 2015/12/15 06:00 DT - 2015/03/31 06:00 YR - 2015 ED - 20151214 RD - 20150330 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25818416 <149. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26644999 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Govshievich A AU - Somogyi RB AU - Brown MH FA - Govshievich, Alexander FA - Somogyi, Ron B FA - Brown, Mitchell H IN - Govshievich, Alexander. Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. IN - Somogyi, Ron B. Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. IN - Brown, Mitchell H. Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. TI - Conservative mastectomies and immediate reconstruction with the use of ADMs. SO - Gland Surgery. 4(6):453-62, 2015 Dec AS - Gland surg.. 4(6):453-62, 2015 Dec NJ - Gland surgery VO - 4 IP - 6 PG - 453-62 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647009 CP - China (Republic : 1949- ) KW - Acellular dermis; breast reconstruction; conservative mastectomy; direct to implant; implant-based AB - BACKGROUND: In recent years, a novel approach to immediate breast reconstruction has been introduced with the advent of acellular dermal matrix (ADM). In the setting of conservative mastectomies where the native skin envelope is preserved, placement of ADM at the lower pole in continuity with the pectoralis major muscle (PMM) provides additional support, allowing direct-to-implant breast reconstruction. The following manuscript presents the senior author's experience with ADM-assisted reconstruction and provides a detailed description of surgical technique along with a comprehensive discussion of patient selection and potential complications. AB - METHODS: A retrospective chart review of patients undergoing direct-to-implant breast reconstruction following skin sparing or nipple sparing mastectomy with the use of ADM (AlloDerm; LifeCell Corp., Branchburg, USA) was conducted at Women's College Hospital in Toronto over a 5-year period [2008-2013]. Demographic data, previous radiation therapy and post-operative complications were recorded. AB - RESULTS: A total of 72 patients representing 119 breasts were identified. Average follow-up was 16 months (range, 3-51 months). Twenty-seven complications were recorded for a complication rate of 22.7% (27/119). Complications included six cases of capsular contracture (Baker III/IV), five cases of red skin syndrome, four cases of rippling, three cases of dehiscence and two cases of seroma. Overall, direct-to-implant reconstruction was successfully completed in 97.5% of breasts (116/119). One case of infection was treated with explantation and conversion to autogenous reconstruction. Two breasts with tissue necrosis or dehiscence had the implants removed and replaced with tissue expanders. Overall reoperation rate was 9.7% (7/72 patients). AB - CONCLUSIONS: ADM assisted direct-to-implant breast reconstruction has been shown to be a safe option for women who are candidates for skin sparing or nipple sparing mastectomies. Judicious patient selection, effective collaboration between the oncologic and reconstructive surgeon, careful evaluation of post-mastectomy skin flaps and precise surgical technique are paramount to the success of this technique. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2015.02.03 PT - Journal Article ID - 10.3978/j.issn.2227-684X.2015.02.03 [doi] ID - gs-04-06-453 [pii] ID - PMC4647009 [pmc] PP - ppublish LG - English DP - 2015 Dec EZ - 2015/12/09 06:00 DA - 2015/12/09 06:01 DT - 2015/12/09 06:00 YR - 2015 ED - 20151208 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26644999 <150. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25853352 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jacobs JM AU - Salzberg CA FA - Jacobs, Jordan Ms FA - Salzberg, C Andrew IN - Jacobs, Jordan Ms. Assistant Professor of Plastic Surgery, Mount Sinai Medical System, New York, NY, USA. TI - Implant-based breast reconstruction with meshes and matrices: biological vs synthetic. [Review] SO - British Journal of Hospital Medicine. 76(4):211-6, 2015 Apr AS - Br J Hosp Med (Lond). 76(4):211-6, 2015 Apr NJ - British journal of hospital medicine (London, England : 2005) VO - 76 IP - 4 PG - 211-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 101257109 IO - Br J Hosp Med (Lond) SB - Index Medicus CP - England MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - *Surgical Mesh AB - This article presents an overview of the different acellular dermal matrices and synthetic meshes used in modern-day primary and secondary implant-based breast reconstruction. Case examples are given, along with a description of the senior author's pioneering direct-to-implant reconstruction. IS - 1750-8460 IL - 1750-8460 DO - https://dx.doi.org/10.12968/hmed.2015.76.4.211 PT - Journal Article PT - Review ID - 10.12968/hmed.2015.76.4.211 [doi] PP - ppublish LG - English DP - 2015 Apr EZ - 2015/04/09 06:00 DA - 2015/10/28 06:00 DT - 2015/04/09 06:00 YR - 2015 ED - 20151027 RD - 20150409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25853352 <151. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26495224 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Singh M AU - Carty M AU - Nuutila K AU - Ricci JA AU - Caterson EJ AU - Caterson SA FA - Singh, Mansher FA - Carty, Matthew FA - Nuutila, Kristo FA - Ricci, Joseph A FA - Caterson, Edward J FA - Caterson, Stephanie A IN - Singh, Mansher. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. IN - Carty, Matthew. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. IN - Nuutila, Kristo. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. IN - Ricci, Joseph A. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. IN - Caterson, Edward J. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. IN - Caterson, Stephanie A. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. TI - Saved by De-epithelialization: DIEP Flap Dermal Skin Regeneration Salvage after Mastectomy Skin Flap Loss. SO - Plastic and Reconstructive Surgery - Global Open. 3(9):e511, 2015 Sep AS - Plast. reconstr. surg., Glob. open. 3(9):e511, 2015 Sep NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 9 PG - e511 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596436 CP - United States AB - BACKGROUND: Wound re-epithelialization has been traditionally described to occur from the dermal appendages of the wound edges. As such, the role of the dermal wound bed in re-epithelialization has been questioned. In a patient undergoing breast reconstruction with free tissue transfer, the buried portions of the free flap skin paddle could be either de-epithelialized or deskinned. In case of mastectomy skin flap loss, the role of de-epithelialized skin in wound healing has not been described before. AB - METHODS: We report a patient with bilateral mastectomies and bilateral deep inferior epigastric perforator flaps whose postoperative course was complicated by bilateral full-thickness mastectomy skin flap loss. Multiple debridements of nonviable skin resulted in exposure of previously buried de-epithelialized skin paddle of the deep inferior epigastric perforator flap. AB - RESULTS: Our study demonstrates self re-epithelialization of the dermal wound bed from the dermal appendages. We noticed multiple noncontiguous neoepidermal islands in the dermal wound bed, which did not communicate with the wound edges. AB - CONCLUSIONS: In case of full-thickness mastectomy skin flap loss, deep vascular plexus present in the dermal bed of the underlying de-epithelialized skin paddle of the free flap converts an otherwise full-thickness wound to a partial-thickness wound. Our study demonstrates the self-epithelialization potential of the de-epithelialized dermal wound bed from the dermal appendages when exposed to air and in the presence of wound healing elements. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000466 PT - Journal Article ID - 10.1097/GOX.0000000000000466 [doi] ID - PMC4596436 [pmc] PP - epublish PH - 2015/06/22 [received] PH - 2015/07/01 [accepted] LG - English EP - 20150910 DP - 2015 Sep EZ - 2015/10/27 06:00 DA - 2015/10/27 06:01 DT - 2015/10/24 06:00 YR - 2015 ED - 20151023 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26495224 <152. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26495218 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Frey JD AU - Alperovich M AU - Weichman KE AU - Wilson SC AU - Hazen A AU - Saadeh PB AU - Levine JP AU - Choi M AU - Karp NS FA - Frey, Jordan D FA - Alperovich, Michael FA - Weichman, Katie E FA - Wilson, Stelios C FA - Hazen, Alexes FA - Saadeh, Pierre B FA - Levine, Jamie P FA - Choi, Mihye FA - Karp, Nolan S IN - Frey, Jordan D. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Alperovich, Michael. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Weichman, Katie E. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Wilson, Stelios C. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Hazen, Alexes. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Saadeh, Pierre B. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Levine, Jamie P. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Choi, Mihye. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. IN - Karp, Nolan S. Department of Plastic Surgery, NYU Langone Medical Center, New York, N.Y.; and Division of Plastic and Reconstructive Surgery, Montefiore Medical Center, New York, N.Y. TI - Breast Reconstruction Using Contour Fenestrated AlloDerm: Does Improvement in Design Translate to Improved Outcomes?. SO - Plastic and Reconstructive Surgery - Global Open. 3(9):e505, 2015 Sep AS - Plast. reconstr. surg., Glob. open. 3(9):e505, 2015 Sep NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 9 PG - e505 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596430 CP - United States AB - BACKGROUND: Acellular dermal matrices are used in implant-based breast reconstruction. The introduction of contour fenestrated AlloDerm (Life-Cell, Branchburg, N.J.) offers sterile processing, a crescent shape, and prefabricated fenestrations. However, any evidence comparing reconstructive outcomes between this newer generation acellular dermal matrices and earlier versions is lacking. AB - METHODS: Patients undergoing implant-based breast reconstruction from 2010 to 2014 were identified. Reconstructive outcomes were stratified by 4 types of implant coverage: aseptic AlloDerm, sterile "ready-to-use" AlloDerm, contour fenestrated AlloDerm, or total submuscular coverage. Outcomes were compared with significance set at P < 0.05. AB - RESULTS: A total of 620 patients (1019 reconstructions) underwent immediate, implant-based breast reconstruction; patients with contour fenestrated AlloDerm were more likely to have nipple-sparing mastectomy (P = 0.0001, 0.0004, and 0.0001) and immediate permanent implant reconstructions (P = 0.0001). Those with contour fenestrated AlloDerm coverage had lower infection rates requiring oral (P = 0.0016) and intravenous antibiotics (P = 0.0012) compared with aseptic AlloDerm coverage. Compared with sterile "ready-to-use" AlloDerm coverage, those with contour fenestrated AlloDerm had similar infection outcomes but significantly more minor mastectomy flap necrosis (P = 0.0023). Compared with total submuscular coverage, those with contour fenestrated AlloDerm coverage had similar infection outcomes but significantly more explantations (P = 0.0001), major (P = 0.0130) and minor mastectomy flap necrosis (P = 0.0001). Significant independent risk factors for increased infection were also identified. AB - CONCLUSIONS: Contour fenestrated AlloDerm reduces infections compared with aseptic AlloDerm, but infection rates are similar to those of sterile, ready-to-use AlloDerm and total submuscular coverage. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000482 PT - Journal Article ID - 10.1097/GOX.0000000000000482 [doi] ID - PMC4596430 [pmc] PP - epublish PH - 2015/03/03 [received] PH - 2015/07/13 [accepted] LG - English EP - 20150904 DP - 2015 Sep EZ - 2015/10/27 06:00 DA - 2015/10/27 06:01 DT - 2015/10/24 06:00 YR - 2015 ED - 20151023 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26495218 <153. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24754867 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Peker F AU - Yuksel F AU - Karagoz H AU - Ozturk S FA - Peker, Fatih FA - Yuksel, Fuat FA - Karagoz, Huseyin FA - Ozturk, Sinan IN - Peker, Fatih. Plastic and Reconstructive Surgery, Private Practice, Istanbul, Turkey. TI - Breast reconstruction using de-epithelialized dermal flap after vertical-pattern skin-sparing mastectomy in macromastia. SO - ANZ Journal of Surgery. 85(1-2):64-8, 2015 Jan AS - ANZ J Surg. 85(1-2):64-8, 2015 Jan NJ - ANZ journal of surgery VO - 85 IP - 1-2 PG - 64-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dze, 101086634 IO - ANZ J Surg SB - Index Medicus CP - Australia MH - Adult MH - *Breast/ab [Abnormalities] MH - Breast/pa [Pathology] MH - Breast/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - Hypertrophy/pa [Pathology] MH - *Hypertrophy/su [Surgery] MH - *Mammaplasty MH - *Mastectomy MH - Retrospective Studies MH - *Surgical Flaps MH - Treatment Outcome KW - breast cancer; de-epithelialized dermal flap; macromastia; skin-reducing mastectomy; skin-sparing mastectomy AB - INTRODUCTION: Prophylactic mastectomy is performed to reduce the risk of breast cancer in high-risk conditions, and expectations about reconstruction are too high. Implant coverage with healthy tissue and skin reducing as an envelope are two concerns in the treatment of macromastia cases. We present our results obtained with a prosthetic reconstruction technique using an inferior pedicled de-epithelialized dermal flap after vertical-pattern skin-sparing mastectomy in this retrospective study. AB - METHODS: Fourteen patients with macromastia and with a high risk of breast malignancy were treated with breast prosthesis using an inferior pedicled de-epithelialized dermal flap after vertical-pattern skin-sparing mastectomy, and were followed for 6 months to 2 years. AB - RESULTS: Good aesthetic results were obtained in all of the patients with increased patient satisfaction. There were no serious complications and the patients were all satisfied. AB - DISCUSSION: Since there is no dangerous T-point in vertical-pattern skin-sparing mastectomy in contrast to an inverted-T wise-pattern technique, where flaps are connected under great tension and susceptible to separation, it can be used safely in macromastia cases, as in smaller breasts. In addition, a de-epithelialized dermal flap is quite useful to cover the inferior pole of the prosthesis and it eliminates the need for an acellular dermal matrix. Copyright © 2014 Royal Australasian College of Surgeons. RS - Gigantomastia ES - 1445-2197 IL - 1445-1433 DO - https://dx.doi.org/10.1111/ans.12570 PT - Journal Article ID - 10.1111/ans.12570 [doi] PP - ppublish PH - 2014/01/13 [accepted] LG - English EP - 20140422 DP - 2015 Jan EZ - 2014/04/24 06:00 DA - 2015/10/22 06:00 DT - 2014/04/24 06:00 YR - 2015 ED - 20151021 RD - 20150126 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24754867 <154. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26218372 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rodriguez-Feliz J AU - Codner MA FA - Rodriguez-Feliz, Jose FA - Codner, Mark A IN - Rodriguez-Feliz, Jose. Atlanta, Ga. From Emory University and Mark Codner MD Plastic Surgery. TI - Embrace the Change: Incorporating Single-Stage Implant Breast Reconstruction into Your Practice. SO - Plastic & Reconstructive Surgery. 136(2):221-31, 2015 Aug AS - Plast Reconstr Surg. 136(2):221-31, 2015 Aug NJ - Plastic and reconstructive surgery VO - 136 IP - 2 PG - 221-31 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Adipose Tissue/tr [Transplantation] MH - Adult MH - Aged MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Esthetics MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - *Nipples MH - Organ Sparing Treatments MH - Patient Selection MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/su [Surgery] MH - Practice Patterns, Physicians'/td [Trends] MH - Reconstructive Surgical Procedures/st [Standards] MH - Reconstructive Surgical Procedures/td [Trends] MH - Retrospective Studies MH - Transplantation, Autologous MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - BACKGROUND: Multiple studies have reported on the safety of nipple-sparing mastectomy and low complication rates associated with single-stage implant breast reconstruction. Yet many plastic surgeons continue to be resistant to change. This article presents the senior author's (M.A.C.) experience during his transition period from the latissimus dorsi flap with adjustable implants to a "one-and-done" approach using shaped implants and fetal bovine acellular dermal matrix. AB - METHODS: A literature review was performed selecting articles discussing single-stage implant reconstruction, indications, outcomes, technique, and complications. Additional articles were selected after review of the references of identified articles. Clinical pearls discussed include patient selection, implant selection, and mastectomy incision choices, with a detailed description of the senior author's operative technique. AB - RESULTS: Twenty-seven single-stage implant reconstructions were performed. Average mastectomy weight was 343.82 g. The average implant volume was 367 cc. Shaped implants were most commonly used. Acellular dermal matrix was used in all breasts. Complications included erythema requiring intravenous antibiotics (three patients), skin ischemia caused by methylene blue (one patient), seroma (one patient), unilateral partial nipple necrosis (one patient), mastectomy skin necrosis (one patient), and exposed/infected implants that were salvaged using a sequential irrigation protocol described by Sforza et al. in 2014 (two patients). AB - CONCLUSIONS: Breast reconstruction after mastectomy has evolved toward less invasive, single-stage procedures. Aesthetic refinements include nipple-sparing mastectomy, use of acellular dermal matrix, shaped implants, and fat grafting. Selected patients will benefit from a one-and-done breast implant reconstruction with no additional oncologic risk. Surgeons must embrace the change and provide their patients with a procedure that will offer the best aesthetic outcomes. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001448 PT - Journal Article ID - 10.1097/PRS.0000000000001448 [doi] ID - 00006534-201508000-00002 [pii] PP - ppublish LG - English DP - 2015 Aug EZ - 2015/07/29 06:00 DA - 2015/10/20 06:00 DT - 2015/07/29 06:00 YR - 2015 ED - 20151019 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26218372 <155. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26430623 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Headon H AU - Kasem A AU - Mokbel K FA - Headon, Hannah FA - Kasem, Adbul FA - Mokbel, Kefah IN - Headon, Hannah. King's College London Medical School, London, UK. IN - Kasem, Adbul. Oncoplastic Breast Surgeon Medway NHS Trust, Kent, UK. IN - Mokbel, Kefah. Aesthetic and Reconstructive Breast Surgery, The London Breast Institute, London, UK. TI - Capsular Contracture after Breast Augmentation: An Update for Clinical Practice. [Review] SO - Archives of Plastic Surgery. 42(5):532-43, 2015 Sep AS - Arch. plast. surg.. 42(5):532-43, 2015 Sep NJ - Archives of plastic surgery VO - 42 IP - 5 PG - 532-43 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579163 CP - Korea (South) KW - Breast implants; Capsular contracture; Mammoplasty AB - Capsular contracture is the most common complication following implant based breast surgery and is one of the most common reasons for reoperation. Therefore, it is important to try and understand why this happens, and what can be done to reduce its incidence. A literature search using the MEDLINE database was conducted including search terms 'capsular contracture breast augmentation', 'capsular contracture pathogenesis', 'capsular contracture incidence', and 'capsular contracture management', which yielded 82 results which met inclusion criteria. Capsular contracture is caused by an excessive fibrotic reaction to a foreign body (the implant) and has an overall incidence of 10.6%. Risk factors that were identified included the use of smooth (vs. textured) implants, a subglandular (vs. submuscular) placement, use of a silicone (vs. saline) filled implant and previous radiotherapy to the breast. The standard management of capsular contracture is surgical via a capsulectomy or capsulotomy. Medical treatment using the off-label leukotriene receptor antagonist Zafirlukast has been reported to reduce severity and help prevent capsular contracture from forming, as has the use of acellular dermal matrices, botox and neopocket formation. However, nearly all therapeutic approaches are associated with a significant rate of recurrence. Capsular contracture is a multifactorial fibrotic process the precise cause of which is still unknown. The incidence of contracture developing is lower with the use of textured implants, submuscular placement and the use of polyurethane coated implants. Symptomatic capsular contracture is usually managed surgically, however recent research has focussed on preventing capsular contracture from occurring, or treating it with autologous fat transfer. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2015.42.5.532 PT - Journal Article PT - Review ID - 10.5999/aps.2015.42.5.532 [doi] ID - PMC4579163 [pmc] PP - ppublish PH - 2015/03/08 [received] PH - 2015/04/09 [revised] PH - 2015/04/13 [accepted] LG - English EP - 20150915 DP - 2015 Sep EZ - 2015/10/03 06:00 DA - 2015/10/03 06:01 DT - 2015/10/03 06:00 YR - 2015 ED - 20151002 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26430623 <156. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26109277 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Potter S AU - Browning D AU - Savovic J AU - Holcombe C AU - Blazeby JM FA - Potter, S FA - Browning, D FA - Savovic, J FA - Holcombe, C FA - Blazeby, J M IN - Potter, S. Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, UK. IN - Browning, D. Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, UK. IN - Browning, D. Department of Surgery, Royal United Hospital, Bath, UK. IN - Savovic, J. Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, UK. IN - Holcombe, C. Breast Unit, Linda McCartney Centre, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. IN - Blazeby, J M. Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, UK. IN - Blazeby, J M. Division of Surgery, Head and Neck, University Hospitals Bristol NHS Foundation Trust, Bristol, UK. TI - Systematic review and critical appraisal of the impact of acellular dermal matrix use on the outcomes of implant-based breast reconstruction. [Review] SO - British Journal of Surgery. 102(9):1010-25, 2015 Aug AS - Br J Surg. 102(9):1010-25, 2015 Aug NJ - The British journal of surgery VO - 102 IP - 9 PG - 1010-25 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - b34, 0372553 IO - Br J Surg SB - Core Clinical Journals (AIM) SB - Index Medicus CP - England MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - Outcome Assessment (Health Care) AB - BACKGROUND: Acellular dermal matrix (ADM) may improve outcomes in implant-based breast reconstruction (IBBR). The aim of this study was critically to appraise and evaluate the current evidence for ADM-assisted IBBR. AB - METHODS: Comprehensive electronic searches identified complete papers published in English between January 2000 and August 2013, reporting any outcome of ADM-assisted IBBR. All systematic reviews, randomized clinical trials (RCTs) and non-randomized studies (NRSs) with more than 20 ADM recipients were included. Studies were critically appraised using AMSTAR for systematic reviews, the Cochrane risk-of-bias tool for RCTs and its adaptation for NRSs. Characteristics and results of identified studies were summarized. AB - RESULTS: A total of 69 papers (8 systematic reviews, 1 RCT, 40 comparative studies and 20 case series) were identified, all of which were considered at high risk of bias, mostly due to patient selection and selective outcome reporting. The median ADM group sample size was 51.0 (i.q.r. 33.0-127.0). Most studies were single-centre (54), and they were often single-surgeon (16). ADM was most commonly used for immediate (40) two-stage IBBR (36) using human ADM (47), with few studies evaluating ADM-assisted single-stage procedures (10). All reported clinical outcomes (for example implant loss) and more than half of the papers (33) assessed process outcomes, but few evaluated cosmesis (16) or patient-reported outcomes (10). Heterogeneity between study design and, especially, outcome measurement precluded meaningful data synthesis. AB - CONCLUSION: Current evidence for the value of ADMs in IBBR is limited. Use in practice should therefore be considered experimental, and evaluation within registries or well designed and conducted studies, ideally RCTs, is recommended to prevent widespread adoption of a potentially inferior intervention. Copyright © 2015 BJS Society Ltd Published by John Wiley & Sons Ltd. ES - 1365-2168 IL - 0007-1323 DO - https://dx.doi.org/10.1002/bjs.9804 PT - Journal Article PT - Review ID - 10.1002/bjs.9804 [doi] PP - ppublish PH - 2014/09/06 [received] PH - 2014/11/30 [revised] PH - 2015/02/10 [accepted] GI - No: MR/K025643/1 Organization: *Medical Research Council* Country: United Kingdom LG - English EP - 20150624 DP - 2015 Aug EZ - 2015/06/26 06:00 DA - 2015/09/26 06:00 DT - 2015/06/26 06:00 YR - 2015 ED - 20150925 RD - 20171110 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26109277 <157. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24941900 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Carruthers CA AU - Dearth CL AU - Reing JE AU - Kramer CR AU - Gagne DH AU - Crapo PM AU - Garcia O Jr AU - Badhwar A AU - Scott JR AU - Badylak SF FA - Carruthers, Christopher A FA - Dearth, Christopher L FA - Reing, Janet E FA - Kramer, Caroline R FA - Gagne, Darcy H FA - Crapo, Peter M FA - Garcia, Onelio Jr FA - Badhwar, Amit FA - Scott, Jeffrey R FA - Badylak, Stephen F IN - Carruthers, Christopher A. 1 Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania. TI - Histologic characterization of acellular dermal matrices in a porcine model of tissue expander breast reconstruction. SO - Tissue engineering. Part A.. 21(1-2):35-44, 2015 Jan AS - Tissue Eng Part A. 21(1-2):35-44, 2015 Jan NJ - Tissue engineering. Part A VO - 21 IP - 1-2 PG - 35-44 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101466659 IO - Tissue Eng Part A PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292858 SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - Disease Models, Animal MH - Female MH - Giant Cells/pa [Pathology] MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mammary Glands, Animal/su [Surgery] MH - Materials Testing MH - Mice MH - NIH 3T3 Cells MH - Neovascularization, Physiologic MH - Sus scrofa MH - *Tissue Expansion Devices AB - BACKGROUND: Acellular dermal matrices (ADMs) have been commonly used in expander-based breast reconstruction to provide inferolateral prosthesis coverage. Although the clinical performance of these biologic scaffold materials varies depending on a number of factors, an in-depth systematic characterization of the host response is yet to be performed. The present study evaluates the biochemical composition and structure of two ADMs, AlloDerm() Regenerative Tissue Matrix and AlloMaxTM Surgical Graft, and provides a comprehensive spatiotemporal characterization in a porcine model of tissue expander breast reconstruction. AB - METHODS: Each ADM was characterized with regard to thickness, permeability, donor nucleic acid content, (residual double-stranded DNA [dsDNA]), and growth factors (basic fibroblast growth factor [bFGF], vascular endothelial growth factor [VEGF], and transforming growth factor-beta 1 [TGF-beta1]). Cytocompatibility was evaluated by in vitro cell culture on the ADMs. The host response was evaluated at 4 and 12 weeks at various locations within the ADMs using established metrics of the inflammatory and tissue remodeling response: cell infiltration, multinucleate giant cell formation, extent of ADM remodeling, and neovascularization. AB - RESULTS: AlloMax incorporated more readily with surrounding host tissue as measured by earlier and greater cell infiltration, fewer foreign body giant cells, and faster remodeling of ADM. These findings correlated with the in vitro composition and cytocompatibility analysis, which showed AlloMax to more readily support in vitro cell growth. AB - CONCLUSIONS: AlloMax and AlloDerm demonstrated distinct remodeling characteristics in a porcine model of tissue expander breast reconstruction. ES - 1937-335X IL - 1937-3341 DO - https://dx.doi.org/10.1089/ten.TEA.2014.0095 PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. ID - 10.1089/ten.TEA.2014.0095 [doi] ID - PMC4292858 [pmc] PP - ppublish GI - No: T32 EB003392 Organization: (EB) *NIBIB NIH HHS* Country: United States LG - English EP - 20140929 DP - 2015 Jan EZ - 2014/06/20 06:00 DA - 2015/09/17 06:00 DT - 2014/06/20 06:00 YR - 2015 ED - 20150916 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24941900 <158. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26111310 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Selber JC AU - Wren JH AU - Garvey PB AU - Zhang H AU - Erickson C AU - Clemens MW AU - Butler CE FA - Selber, Jesse C FA - Wren, James H FA - Garvey, Patrick B FA - Zhang, Hong FA - Erickson, Cameron FA - Clemens, Mark W FA - Butler, Charles E IN - Selber, Jesse C. Houston, Texas From the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center. TI - Critical Evaluation of Risk Factors and Early Complications in 564 Consecutive Two-Stage Implant-Based Breast Reconstructions Using Acellular Dermal Matrix at a Single Center. SO - Plastic & Reconstructive Surgery. 136(1):10-20, 2015 Jul AS - Plast Reconstr Surg. 136(1):10-20, 2015 Jul NJ - Plastic and reconstructive surgery VO - 136 IP - 1 PG - 10-20 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - Adult MH - Animals MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - Cattle MH - Device Removal/sn [Statistics & Numerical Data] MH - Female MH - Follow-Up Studies MH - Humans MH - Logistic Models MH - Middle Aged MH - Multivariate Analysis MH - Outcome Assessment (Health Care) MH - *Postoperative Complications/et [Etiology] MH - Retrospective Studies MH - Risk Factors AB - BACKGROUND: Acellular dermal matrix for implant-based breast reconstruction appears to cause higher early complication rates, but long-term outcomes are perceived to be superior. This dichotomy is the subject of considerable debate. The authors hypothesized that patient characteristics and operative variables would have a greater impact on complications than the type of acellular dermal matrix used. AB - METHODS: A retrospective cohort study was performed of consecutive patients who underwent two-stage, implant-based breast reconstruction with human cadaveric or bovine acellular dermal matrix from 2006 to 2012 at a single institution. Patient characteristics and operative variables were analyzed using logistic regression analyses to identify risk factors for complications. AB - RESULTS: The authors included 564 reconstructions in the study. Radiation therapy and obesity increased the odds of all complications. Every 100-ml increase in preoperative breast volume increased the odds of any complication by 1 percent, the odds of infection by 27 percent, and the risk of explantation by 16 percent. The odds of seroma increased linearly with increasing surface area of acellular dermal matrix. Odds of infection were higher with an intraoperative expander fill volume greater than 50 percent of the total volume. Risk of explantation was twice as high when intraoperative expander fill volume was greater than 300 ml. AB - CONCLUSIONS: Radiation therapy, obesity, larger breasts, higher intraoperative fill volumes, and larger acellular dermal matrices are all independent risk factors for early complications. Maximizing the initial mastectomy skin envelope fill must be balanced with the understanding that higher complication rates may result from a larger intraoperative breast mound. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001327 PT - Evaluation Studies PT - Journal Article ID - 10.1097/PRS.0000000000001327 [doi] ID - 00006534-201507000-00002 [pii] PP - ppublish LG - English DP - 2015 Jul EZ - 2015/06/26 06:00 DA - 2015/09/08 06:00 DT - 2015/06/26 06:00 YR - 2015 ED - 20150907 RD - 20150626 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26111310 <159. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25311295 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kilchenmann AJ AU - Lardi AM AU - Ho-Asjoe M AU - Junge K AU - Farhadi J FA - Kilchenmann, Ashley J R FA - Lardi, Alessia M FA - Ho-Asjoe, Mark FA - Junge, Klaus FA - Farhadi, Jian IN - Kilchenmann, Ashley J R. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Plastic and Reconstructive Surgery, Guy's and St. Thomas' Hospital, Westminster Bridge Rd, SE1 7EH London, United Kingdom. Electronic address: ashley.kilchenmann@stud.unibas.ch. IN - Lardi, Alessia M. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Plastic and Reconstructive Surgery, Guy's and St. Thomas' Hospital, Westminster Bridge Rd, SE1 7EH London, United Kingdom. IN - Ho-Asjoe, Mark. Department of Plastic and Reconstructive Surgery, Guy's and St. Thomas' Hospital, Westminster Bridge Rd, SE1 7EH London, United Kingdom. IN - Junge, Klaus. Premier Research Germany Ltd., Europaplatz 5, 64293 Darmstadt, Germany. IN - Farhadi, Jian. Department of Plastic and Reconstructive Surgery, Guy's and St. Thomas' Hospital, Westminster Bridge Rd, SE1 7EH London, United Kingdom. TI - An evaluation of resource utilisation of single stage porcine acellular dermal matrix assisted breast reconstruction: A comparative study. SO - Breast. 23(6):876-82, 2014 Dec AS - BREAST. 23(6):876-82, 2014 Dec NJ - Breast (Edinburgh, Scotland) VO - 23 IP - 6 PG - 876-82 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9213011 IO - Breast SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - Aged MH - Ambulatory Care/sn [Statistics & Numerical Data] MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/pc [Prevention & Control] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - *Health Resources/ut [Utilization] MH - Hospitalization/sn [Statistics & Numerical Data] MH - Humans MH - Length of Stay/sn [Statistics & Numerical Data] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Operative Time MH - Patient Readmission/sn [Statistics & Numerical Data] MH - Prophylactic Surgical Procedures/mt [Methods] MH - Retrospective Studies MH - *Surgical Flaps MH - *Tissue Expansion Devices KW - Acellular dermal matrix; Breast reconstruction; Health-care analysis; Resource utilisation AB - OBJECTIVES: To evaluate resource utilization of single stage porcine acellular dermal matrix (ADM) assisted breast reconstruction compared with tissue expander (TE), latissimus dorsi flap and implant (LD/I) and latissimus dorsi flap and TE (LD/TE) reconstructive techniques. AB - MATERIALS AND METHODS: Clinical data was collected for length of stay, operative time, additional hospitalisations and operative procedures, and outpatient appointments for 101 patients undergoing unilateral implant based breast reconstruction. Resources utilised by ADM (Strattice Reconstructive Tissue MatrixTM) patients were analysed and compared to the resource usage of traditional techniques. AB - RESULTS: 25 patients undergoing single stage ADM (ADM/I) were compared with 27 having TE, 32 having LD/I and 17 having LD/TE reconstructions. Follow up was 24 months. Compared to TE, ADM/I had similar length of stay and operative time, lower rate and number of additional procedures, fewer, shorter re-admissions (p < 0.05) and fewer appointments (p < 0.05). Compared to LD/TE, ADM/I had shorter length of stay and operative time (p < 0.05), lower rate and number of additional procedures, fewer, shorter re-admissions (p < 0.05) and fewer appointments (p < 0.05). Compared to LD/I, ADM/I had shorter length of stay (p < 0.05) and operative time (p < 0.05), fewer appointments, similar rate and number of additional procedures but required more and longer re-admissions. AB - CONCLUSION: In our experience, unilateral single stage ADM/I was associated with fewer resources utilised in comparison with two staged TE and LD/TE reconstructions in both complication-free and complicated settings over a 24-month period, despite requiring aesthetic revision in 60.9% of patients. Compared to LD/I, resource utilisation was commensurate in complication-free and complicated settings. Copyright © 2014 Elsevier Ltd. All rights reserved. ES - 1532-3080 IL - 0960-9776 DI - S0960-9776(14)00176-3 DO - https://dx.doi.org/10.1016/j.breast.2014.09.008 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S0960-9776(14)00176-3 [pii] ID - 10.1016/j.breast.2014.09.008 [doi] PP - ppublish PH - 2014/06/13 [received] PH - 2014/09/05 [revised] PH - 2014/09/22 [accepted] LG - English EP - 20141011 DP - 2014 Dec EZ - 2014/10/15 06:00 DA - 2015/08/25 06:00 DT - 2014/10/15 06:00 YR - 2014 ED - 20150824 RD - 20141222 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25311295 <160. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26301161 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Hadad I AU - Liu AS AU - Guo L FA - Hadad, Ivan FA - Liu, Allen S FA - Guo, Lifei IN - Hadad, Ivan. Division of Plastic Surgery, Indiana University, Indianapolis, Ind.; Arizona Center for Hand Surgery, Phoenix, Ariz.; and Department of Plastic Surgery, Lahey Hospital & Medical Center, Burlington, Mass. IN - Liu, Allen S. Division of Plastic Surgery, Indiana University, Indianapolis, Ind.; Arizona Center for Hand Surgery, Phoenix, Ariz.; and Department of Plastic Surgery, Lahey Hospital & Medical Center, Burlington, Mass. IN - Guo, Lifei. Division of Plastic Surgery, Indiana University, Indianapolis, Ind.; Arizona Center for Hand Surgery, Phoenix, Ariz.; and Department of Plastic Surgery, Lahey Hospital & Medical Center, Burlington, Mass. TI - A New Approach to Minimize Acellular Dermal Matrix Use in Prosthesis-based Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 3(7):e472, 2015 Jul AS - Plast. reconstr. surg., Glob. open. 3(7):e472, 2015 Jul NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 7 PG - e472 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527646 CP - United States AB - BACKGROUND: Acellular dermal matrices (ADMs) are often used to improve lower-pole contour, as well as allow for single-stage reconstruction, but numerous studies have shown an increased complication rate using ADM. As such, our group has developed a minimal-ADM-use technique to lower complications while effectively recreating lower-pole contour. AB - METHODS: A total of 380 postmastectomy prosthesis-based breast reconstructions were performed in 265 patients by a single surgeon. One hundred eight reconstructions were performed using the traditional ADM technique, with a large piece of ADM along the entire inferior and lateral borders. Two hundred twenty-five reconstructions were performed with the minimal-use technique, patching only the lateral area of the reconstruction. Thirty-five reconstructions were performed without the use of any ADM for high-risk reconstructions, most often in morbidly obese patients. AB - RESULTS: Comparing the traditional technique with the minimal-use technique, the seroma rate dropped from 3% to 0%. The rate of infection and reconstruction loss fell from 9% to 1%. Upon greatly reducing or eliminating the use of ADM use in obese patients, the seroma rate decreased from 15.4% to 5.7%, and the reconstruction loss rate decreased from 38% to 9%. AB - CONCLUSIONS: This article describes a new surgical approach to minimize the amount of ADM necessary to create an aesthetically pleasing breast reconstruction. We believe that this approach helps avoid the complications of seroma, infection, and loss of the reconstruction. In certain obese patients, total avoidance of ADM may be the better choice. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000433 PT - Journal Article ID - 10.1097/GOX.0000000000000433 [doi] ID - PMC4527646 [pmc] PP - epublish PH - 2013/09/10 [received] PH - 2015/05/28 [accepted] LG - English EP - 20150810 DP - 2015 Jul EZ - 2015/08/25 06:00 DA - 2015/08/25 06:01 DT - 2015/08/25 06:00 YR - 2015 ED - 20150824 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26301161 <161. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24051466 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Madsen RJ Jr AU - Chim J AU - Ang B AU - Fisher O AU - Hansen J FA - Madsen, Russell J Jr FA - Chim, Jimmy FA - Ang, Brian FA - Fisher, Orna FA - Hansen, Juliana IN - Madsen, Russell J Jr. From the Division of Plastic and Reconstructive Surgery, Oregon Health & Science University, Portland, OR. TI - Variance in the origin of the pectoralis major muscle: implications for implant-based breast reconstruction. SO - Annals of Plastic Surgery. 74(1):111-3, 2015 Jan AS - Ann Plast Surg. 74(1):111-3, 2015 Jan NJ - Annals of plastic surgery VO - 74 IP - 1 PG - 111-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adolescent MH - Adult MH - Aged MH - *Breast Implantation MH - Female MH - Humans MH - Mastectomy MH - Middle Aged MH - *Pectoralis Muscles/ah [Anatomy & Histology] MH - Pectoralis Muscles/su [Surgery] MH - *Surgical Flaps MH - Young Adult AB - BACKGROUND: The pectoralis major muscle plays a crucial role in implant-based breast reconstruction. The goal of this study is to document variations of the origin of the pectoralis major muscle (PM). We hope to understand how many women have anatomy allowing for total submuscular coverage of an implant with the PM alone in immediate breast reconstruction. AB - METHODS: Fifty patients undergoing mastectomy were recruited. Breast width and the costal origin of the natural inframammary fold (IMF) were measured preoperatively and intraoperatively. The PM width at its origin and the rib origin of the PM were measured intraoperatively. A ratio of the PM origin width to breast width was calculated. AB - RESULTS: Forty-four percent of breasts studied had the IMF at the level of the seventh rib, 53% at the sixth rib, and 3% at the fifth rib. Twenty percent of PM muscles originated from the seventh rib, 68% from the sixth rib, and 12% from the fifth rib. Thirty-six percent of chests showed a PM originating one rib level above the IMF, 61% at the same level, and 3% one level below the IMF. Seventy-seven percent of chests showed a PM origin width to breast width ratio of <0.8. AB - CONCLUSIONS: Overall, 72% of chests had either a high origin of the PM, a narrow PM relative to the breast width, or both. This anatomy is suboptimal for implant coverage using the PM alone. Surgeons performing implant-based breast reconstruction should be prepared to utilize wide dissection, alternative muscle recruitment, or supplemental acellular dermal matrix. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3182858881 PT - Journal Article ID - 10.1097/SAP.0b013e3182858881 [doi] PP - ppublish LG - English DP - 2015 Jan EZ - 2013/09/21 06:00 DA - 2015/08/22 06:00 DT - 2013/09/21 06:00 YR - 2015 ED - 20150821 RD - 20141216 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24051466 <162. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25936815 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fowble B AU - Park C AU - Wang F AU - Peled A AU - Alvarado M AU - Ewing C AU - Esserman L AU - Foster R AU - Sbitany H AU - Hanlon A FA - Fowble, Barbara FA - Park, Catherine FA - Wang, Frederick FA - Peled, Anne FA - Alvarado, Michael FA - Ewing, Cheryl FA - Esserman, Laura FA - Foster, Robert FA - Sbitany, Hani FA - Hanlon, Alex IN - Fowble, Barbara. Department of Radiation Oncology, University of California San Francisco, San Francisco, California. Electronic address: BFowble@radonc.ucsf.edu. IN - Park, Catherine. Department of Radiation Oncology, University of California San Francisco, San Francisco, California. IN - Wang, Frederick. Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California. IN - Peled, Anne. Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California. IN - Alvarado, Michael. Carol Franc Buck Breast Care Center, Department of Surgery, University of California San Francisco, San Francisco, California. IN - Ewing, Cheryl. Carol Franc Buck Breast Care Center, Department of Surgery, University of California San Francisco, San Francisco, California. IN - Esserman, Laura. Carol Franc Buck Breast Care Center, Department of Surgery, University of California San Francisco, San Francisco, California. IN - Foster, Robert. Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California. IN - Sbitany, Hani. Division of Plastic and Reconstructive Surgery, University of California San Francisco, San Francisco, California. IN - Hanlon, Alex. University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania. TI - Rates of Reconstruction Failure in Patients Undergoing Immediate Reconstruction With Tissue Expanders and/or Implants and Postmastectomy Radiation Therapy. SO - International Journal of Radiation Oncology, Biology, Physics. 92(3):634-41, 2015 Jul 01 AS - Int J Radiat Oncol Biol Phys. 92(3):634-41, 2015 Jul 01 NJ - International journal of radiation oncology, biology, physics VO - 92 IP - 3 PG - 634-41 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - g97, 7603616 IO - Int. J. Radiat. Oncol. Biol. Phys. SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - Analysis of Variance MH - Body Weight MH - *Breast Implants MH - Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/ge [Genetics] MH - *Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Cicatrix/co [Complications] MH - Cicatrix/pa [Pathology] MH - Female MH - Genes, BRCA1 MH - Genes, BRCA2 MH - Humans MH - Intermediate Back Muscles/tr [Transplantation] MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - *Mastectomy MH - Middle Aged MH - Molecular Targeted Therapy MH - Organ Sparing Treatments/mt [Methods] MH - Radiotherapy Dosage MH - Radiotherapy, Conformal/mt [Methods] MH - Retrospective Studies MH - *Tissue Expansion Devices MH - Treatment Failure AB - OBJECTIVES: Mastectomy rates for breast cancer have increased, with a parallel increase in immediate reconstruction. For some women, tissue expander and implant (TE/I) reconstruction is the preferred or sole option. This retrospective study examined the rate of TE/I reconstruction failure (ie, removal of the TE or I with the inability to replace it resulting in no final reconstruction or autologous tissue reconstruction) in patients receiving postmastectomy radiation therapy (PMRT). AB - METHODS AND MATERIALS: Between 2004 and 2012, 99 women had skin-sparing mastectomies (SSM) or total nipple/areolar skin-sparing mastectomies (TSSM) with immediate TE/I reconstruction and PMRT for pathologic stage II to III breast cancer. Ninety-seven percent had chemotherapy (doxorubicin and taxane-based), 22% underwent targeted therapies, and 78% had endocrine therapy. Radiation consisted of 5000 cGy given in 180 to 200 cGy to the reconstructed breast with or without treatment to the supraclavicular nodes. Median follow-up was 3.8 years. AB - RESULTS: Total TE/I failure was 18% (12% without final reconstruction, 6% converted to autologous reconstruction). In univariate analysis, the strongest predictor of reconstruction failure (RF) was absence of total TE/I coverage (acellular dermal matrix and/or serratus muscle) at the time of radiation. RF occurred in 32.5% of patients without total coverage compared to 9% with coverage (P=.0069). For women with total coverage, the location of the mastectomy scar in the inframammary fold region was associated with higher RF (19% vs 0%, P=.0189). In multivariate analysis, weight was a significant factor for RF, with lower weight associated with a higher RF. Weight appeared to be a surrogate for the interaction of total coverage, thin skin flaps, interval to exchange, and location of the mastectomy scar. AB - CONCLUSIONS: RFs in patients receiving PMRT were lowered with total TE/I coverage at the time of radiation by avoiding inframammary fold incisions and with a preferred interval of 6 months to exchange. Copyright © 2015 Elsevier Inc. All rights reserved. ES - 1879-355X IL - 0360-3016 DI - S0360-3016(15)00219-9 DO - https://dx.doi.org/10.1016/j.ijrobp.2015.02.031 PT - Journal Article ID - S0360-3016(15)00219-9 [pii] ID - 10.1016/j.ijrobp.2015.02.031 [doi] PP - ppublish PH - 2014/12/18 [received] PH - 2015/02/06 [revised] PH - 2015/02/17 [accepted] LG - English EP - 20150428 DP - 2015 Jul 01 EZ - 2015/05/06 06:00 DA - 2015/08/21 06:00 DT - 2015/05/05 06:00 YR - 2015 ED - 20150820 RD - 20150613 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25936815 <163. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26020380 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wilson HB FA - Wilson, Henry Benjamin IN - Wilson, Henry Benjamin. From the Centra Health, Inc., Division of Plastic Surgery and Liberty University College of Osteopathic Medicine, Lynchburg, Virginia, USA. TI - New Deep Dermal ADM Incorporates Well in Case Series of Complex Breast Reconstruction Patients. SO - Medicine. 94(21):e745, 2015 May AS - Medicine (Baltimore). 94(21):e745, 2015 May NJ - Medicine VO - 94 IP - 21 PG - e745 PI - Journal available in: Print PI - Citation processed from: Internet JC - mny, 2985248r IO - Medicine (Baltimore) PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616406 SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - *Breast Neoplasms/su [Surgery] MH - Collagen MH - Female MH - Humans MH - Length of Stay MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Patient Satisfaction MH - Postoperative Care MH - Prosthesis-Related Infections/ep [Epidemiology] MH - Tissue Expansion Devices AB - Breast cancer patients with significant comorbidities present reconstructive challenges due to a predictably high complication rate. During expander-based breast reconstruction, human acellular dermal matrix (ADM) is often used to prevent pectoralis muscle retraction, facilitate early expansion, and improve cosmetic outcome. Device infection and chronic seroma have been correlated to the addition of the graft by some large database reports but not others. This study describes the first reported experience with a new deep dermal ADM, FlexHD PliableTM (MTF, Edison, NJ). Sixteen breasts in 10 consecutive patients identified retrospectively and followed prospectively had immediate expander-based breast reconstruction utilizing the new ADM. Patient comorbidities were catalogued, complications were recorded, and overall reconstructive success was assessed. At implant exchange, the ADM was examined for tissue ingrowth and biopsied for histologic examination. All 16 breasts had successful reconstructions. Two breasts (12.5%) developed device infection, requiring removal and later replacement of the expander. One breast (6.7%) developed chronic seroma, also requiring expander removal and later replacement. All the complicated patients had significant comorbidities, including obesity in all 3. At expander removal, the FlexHD Pliable showed near-complete visual tissue incorporation in 14 of 16 breasts (88%). This case series demonstrates significant reconstructive success in challenging patients utilizing a novel ADM. Visual and histologic assessment of tissue ingrowth into the graft suggests the high rate of complication may be due to patient comorbidities rather than addition of ADM. Additional experience is needed to confirm and the study is ongoing. RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1536-5964 IL - 0025-7974 DO - https://dx.doi.org/10.1097/MD.0000000000000745 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/MD.0000000000000745 [doi] ID - 00005792-201505050-00005 [pii] ID - PMC4616406 [pmc] PP - ppublish LG - English DP - 2015 May EZ - 2015/05/29 06:00 DA - 2015/08/12 06:00 DT - 2015/05/29 06:00 YR - 2015 ED - 20150811 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26020380 <164. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26017603 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Banyard DA AU - Bourgeois JM AU - Widgerow AD AU - Evans GR FA - Banyard, Derek A FA - Bourgeois, Jenna Martin FA - Widgerow, Alan D FA - Evans, Gregory R D IN - Banyard, Derek A. Orange, Calif. From the Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine. TI - Regenerative biomaterials: a review. [Review] SO - Plastic & Reconstructive Surgery. 135(6):1740-8, 2015 Jun AS - Plast Reconstr Surg. 135(6):1740-8, 2015 Jun NJ - Plastic and reconstructive surgery VO - 135 IP - 6 PG - 1740-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Abdominal Wall/su [Surgery] MH - Acellular Dermis MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mammaplasty/mt [Methods] MH - Patient Safety MH - Reconstructive Surgical Procedures/ae [Adverse Effects] MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Rhinoplasty/mt [Methods] MH - Risk Assessment MH - Surgical Mesh MH - Thoracic Wall/su [Surgery] MH - *Wound Healing/ph [Physiology] AB - The authors present a review of biomaterials, substances traditionally derived from human or animal tissue or, more recently, biodegradable synthetics modeled after naturally occurring resources. These constructs differ from purely synthetic materials in that they are degraded or incorporated into a host's tissue. These biomaterials include a diverse array of medical products, such as acellular dermal matrix, bone substitutes, and injectables. In this review, the authors examine various clinical applications, including burn reconstruction and wound healing, breast surgery, complex abdominal wall reconstruction, craniofacial repair, and cosmetic surgery. Biomaterials such as acellular dermal matrix have proven beneficial in difficult-to-treat applications; however, more prospective data are needed to determine their true efficacy and cost-effectiveness. RN - 0 (Biocompatible Materials) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001272 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000001272 [doi] ID - 00006534-201506000-00035 [pii] PP - ppublish LG - English DP - 2015 Jun EZ - 2015/05/29 06:00 DA - 2015/08/06 06:00 DT - 2015/05/29 06:00 YR - 2015 ED - 20150805 RD - 20150528 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=26017603 <165. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24859403 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gubitosi A AU - Docimo G AU - Parmeggiani D AU - Pirozzi R AU - Vitiello C AU - Schettino P AU - Avellino M AU - Casalino G AU - Amato M AU - Ruggiero R AU - Docimo L FA - Gubitosi, A FA - Docimo, G FA - Parmeggiani, D FA - Pirozzi, R FA - Vitiello, C FA - Schettino, P FA - Avellino, M FA - Casalino, G FA - Amato, M FA - Ruggiero, R FA - Docimo, L IN - Gubitosi, A. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Docimo, G. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Parmeggiani, D. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Pirozzi, R. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Vitiello, C. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Schettino, P. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Avellino, M. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Casalino, G. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. IN - Amato, M. Department of Clinical Medicine and Surgery, University of Naples Federico II, Italy. IN - Ruggiero, R. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. Electronic address: roberto.ruggiero@unina2.it. IN - Docimo, L. Department of Surgery, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. TI - Acellular bovine pericardium dermal matrix in immediate breast reconstruction after Skin Sparing Mastectomy. SO - International Journal Of Surgery. 12 Suppl 1:S205-8, 2014 AS - Int J Surg. 12 Suppl 1:S205-8, 2014 NJ - International journal of surgery (London, England) VO - 12 Suppl 1 PG - S205-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101228232 IO - Int J Surg SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Aged MH - Animals MH - Breast Neoplasms/su [Surgery] MH - Cattle MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Pericardium/tr [Transplantation] MH - Prospective Studies MH - Retrospective Studies MH - *Skin Transplantation/mt [Methods] AB - INTRODUCTION: Mastectomy for breast cancer may bring the patient to develop long term issues concerning the psychological and physical status. Immediate breast reconstruction (IBR) should be considered and proposed by physicians as an integrated procedure in the surgical approach to breast cancer to reduce further surgery. Acellular dermal matrix (ADM) has been used in revision breast reconstruction for fold malposition, capsular contracture and rippling also, showing good outcomes with low risk of complications. Aim of this study was to verify if the known advantages in using ADM for IBR would led to lower rates of seroma formation, infection, skin flap necrosis and overall complication related to the implant. AB - METHODS: We performed a prospective study, including all consecutive patients undergone to IBR with biological graft with ADM between January 2012 and January 2013 at our Institution. Data on major issues of the patients and complications were recorded. All patients underwent to IBR with ADM (Tutomesh) implant with or without fibrin sealant positioning. AB - RESULTS: A total of 24 patients underwent 28 immediate breast reconstruction with Tutomesh ADM implant. Main postoperative complications included seroma formation in 20.8% (5 pts), infection in 8.3% (2 pts) and hematoma in 4.2% (1 pt). There were any skin flap necrosis in the study. Diabetes was associated in two cases with edema and ecchymosis; hypertension with infection in one case (implant removal) and seroma in one case. First class of obesity (BMI 30-32.7) was associated with seroma in 3 cases, and with infection in one. In patient without fibrin sealant (12 patients - 13 breasts) complications were represented by hematoma (1 pt. 4.2%), infection (1 pt. 4.2%; implant removal) and seroma (4 pts 16.8%). AB - CONCLUSIONS: The use of Tutomesh() bovine pericardium for immediate breast is safe and technically useful. Complications rate is not high, except for seroma formation that can be reduced by the contemporary use of fibrin sealant. Copyright © 2014. Published by Elsevier Ltd. ES - 1743-9159 IL - 1743-9159 DI - S1743-9191(14)00106-X DO - https://dx.doi.org/10.1016/j.ijsu.2014.05.007 PT - Journal Article ID - S1743-9191(14)00106-X [pii] ID - 10.1016/j.ijsu.2014.05.007 [doi] PP - ppublish PH - 2014/03/23 [received] PH - 2014/05/03 [accepted] LG - English EP - 20140522 DP - 2014 EZ - 2014/05/27 06:00 DA - 2015/08/05 06:00 DT - 2014/05/27 06:00 YR - 2014 ED - 20150804 RD - 20140809 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24859403 <166. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25778875 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Borsen-Koch M AU - Gunnarsson GL AU - Udesen A AU - Arffmann S AU - Jacobs J AU - Salzberg A AU - Thomsen JB FA - Borsen-Koch, Mikkel FA - Gunnarsson, Gudjon L FA - Udesen, Ann FA - Arffmann, Susanne FA - Jacobs, Jordan FA - Salzberg, Andrew FA - Thomsen, Jorn B IN - Borsen-Koch, Mikkel. Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Vejle, Denmark. IN - Gunnarsson, Gudjon L. Department of Plastic Surgery, Telemark Hospital, Skien, Norway. IN - Udesen, Ann. Department of Plastic Surgery, Odense University Hospital, Odense, Denmark. IN - Arffmann, Susanne. Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Vejle, Denmark. IN - Jacobs, Jordan. Division of Plastic Surgery, New York Medical College, New York, NY, USA. IN - Salzberg, Andrew. Division of Plastic Surgery, New York Medical College, New York, NY, USA. IN - Thomsen, Jorn B. Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Vejle, Denmark. Electronic address: jbth@dadlnet.dk. TI - Direct delayed breast reconstruction with TAP flap, implant and acellular dermal matrix (TAPIA). SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 68(6):815-21, 2015 Jun AS - J Plast Reconstr Aesthet Surg. 68(6):815-21, 2015 Jun NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 68 IP - 6 PG - 815-21 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implants MH - Female MH - Hematoma/et [Etiology] MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Necrosis/et [Etiology] MH - *Perforator Flap/pa [Pathology] MH - Time Factors MH - Tissue and Organ Harvesting/ae [Adverse Effects] MH - *Tissue and Organ Harvesting/mt [Methods] MH - Transplant Donor Site KW - Acellular dermal matrix; Breast cancer; Breast reconstruction; Latissimus dorsi flap; Thoracodorsal perforator flap AB - BACKGROUND: The latissimus dorsi (LD) flap is considered one of the working horses within the field of breast reconstruction and it offers several advantages. However, donor-site morbidity may pose a problem. This article describes a new and modified technique for delayed breast reconstruction combining the use of a propeller thoracodorsal artery perforator (TAP) flap with an acellular dermal matrix (ADM) and an implant. AB - METHODS: The paper presents 43 delayed breast reconstructions in 38 women using a modified technique for harvesting the TAP flap in combination with an ADM and an implant for total breast reconstruction. The focus of this paper is the refinements of our technique and short-term outcome in complication rates. The data presented were collected retrospectively. AB - RESULTS: Three patients experienced major complications including hematoma, partial flap necrosis, and venous congestion. In addition, seven patients experienced minor complications including small partial flap necrosis and epidermolysis. There were no cases of infection and all flaps survived. The reconstructive goal was achieved in a single-stage procedure in all but one, 42/43 cases (98%). AB - CONCLUSIONS: The propeller TAP flap combined with an ADM and an implant can safely be used for delayed breast reconstruction. The technique offers a single-stage reconstruction and the donor-site morbidity is limited. The method is safe and reliable with complication rates comparable to those of similar methods. Although there is a learning curve, this simple modified technique does not demand any perforator or other vessel dissection. Any trained plastic surgeon should be able to adopt the technique into the growing armamentarium of breast reconstruction possibilities. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(15)00071-6 DO - https://dx.doi.org/10.1016/j.bjps.2015.02.004 PT - Journal Article PT - Video-Audio Media ID - S1748-6815(15)00071-6 [pii] ID - 10.1016/j.bjps.2015.02.004 [doi] PP - ppublish PH - 2014/02/18 [received] PH - 2014/12/15 [revised] PH - 2015/02/03 [accepted] LG - English EP - 20150213 DP - 2015 Jun EZ - 2015/03/18 06:00 DA - 2015/07/30 06:00 DT - 2015/03/18 06:00 YR - 2015 ED - 20150729 RD - 20150525 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25778875 <167. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26180740 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Eichler C AU - Vogt N AU - Brunnert K AU - Sauerwald A AU - Puppe J AU - Warm M FA - Eichler, Christian FA - Vogt, Nadine FA - Brunnert, Klaus FA - Sauerwald, Axel FA - Puppe, Julian FA - Warm, Mathias IN - Eichler, Christian. Breast Center, Municipal Hospital Holweide, Cologne, Germany; Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany; Department of Senology, Clinic for Senology, Osnabrueck, Germany; Department of Gynecology and Obstetrics, Hospital Duren GmbH, Duren, Germany; and Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Vogt, Nadine. Breast Center, Municipal Hospital Holweide, Cologne, Germany; Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany; Department of Senology, Clinic for Senology, Osnabrueck, Germany; Department of Gynecology and Obstetrics, Hospital Duren GmbH, Duren, Germany; and Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Brunnert, Klaus. Breast Center, Municipal Hospital Holweide, Cologne, Germany; Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany; Department of Senology, Clinic for Senology, Osnabrueck, Germany; Department of Gynecology and Obstetrics, Hospital Duren GmbH, Duren, Germany; and Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Sauerwald, Axel. Breast Center, Municipal Hospital Holweide, Cologne, Germany; Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany; Department of Senology, Clinic for Senology, Osnabrueck, Germany; Department of Gynecology and Obstetrics, Hospital Duren GmbH, Duren, Germany; and Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Puppe, Julian. Breast Center, Municipal Hospital Holweide, Cologne, Germany; Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany; Department of Senology, Clinic for Senology, Osnabrueck, Germany; Department of Gynecology and Obstetrics, Hospital Duren GmbH, Duren, Germany; and Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. IN - Warm, Mathias. Breast Center, Municipal Hospital Holweide, Cologne, Germany; Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany; Department of Senology, Clinic for Senology, Osnabrueck, Germany; Department of Gynecology and Obstetrics, Hospital Duren GmbH, Duren, Germany; and Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. TI - A Head-to-head Comparison between SurgiMend and Epiflex in 127 Breast Reconstructions. SO - Plastic and Reconstructive Surgery - Global Open. 3(6):e439, 2015 Jun AS - Plast. reconstr. surg., Glob. open. 3(6):e439, 2015 Jun NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 6 PG - e439 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494509 CP - United States AB - BACKGROUND: The use of acellular dermal matrices (ADM) has become a widely used option in breast reconstruction. A great deal of literature is available, totaling over 2400 ADM reconstructions. Nonetheless, head-to-head comparisons between SurgiMend and Epiflex are not yet reported. In fact, this is the first clinical data report on the use of Epiflex. This work will, therefore, compare postoperative complication rates and costs for these ADMs. AB - METHODS: This analysis is a retrospective review of a single surgeon's 6-year experience with both SurgiMend-an acellular bovine dermal collagen matrix for soft-tissue reconstruction and Epiflex-a decellularized human skin tissue from 2008 to 2013. AB - RESULTS: One hundred patients had a total of 127 implant-based reconstructions using SurgiMend (64 cases; 50.4%) or Epiflex (63 cases; 49.6%). Gross complication rates were 11.1% for SurgiMend and 40.6% for Epiflex including hematoma, postoperative skin irritation, infection, necrosis, and revision surgery. The most common complication was postoperative red breast syndrome. Severe complications requiring revision surgery were significantly increased in patients treated with Epiflex (12.5%) compared with SurgiMend (4.8%). AB - CONCLUSIONS: This retrospective analysis favors the use of SurgiMend over Epiflex because of significantly lower gross complication rates. Severe complication rates are comparable with those reported in literature for both products. Although results promote the use of SurgiMend, the single surgeon retrospective nature of this work limits its clinical impact. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000409 PT - Journal Article ID - 10.1097/GOX.0000000000000409 [doi] ID - PMC4494509 [pmc] PP - epublish PH - 2014/12/20 [received] PH - 2013/05/04 [accepted] LG - English EP - 20150708 DP - 2015 Jun EZ - 2015/07/17 06:00 DA - 2015/07/17 06:01 DT - 2015/07/17 06:00 YR - 2015 ED - 20150716 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26180740 <168. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26180713 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Becker H AU - Lind JG 2nd AU - Hopkins EG FA - Becker, Hilton FA - Lind, Jeffrey G 2nd FA - Hopkins, Elizabeth G IN - Becker, Hilton. Hilton Becker Clinic of Plastic Surgery, Boca Raton, Fla.; Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Fla.; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Fla.; and Florida Atlantic University, Boca Raton, Fla. IN - Lind, Jeffrey G 2nd. Hilton Becker Clinic of Plastic Surgery, Boca Raton, Fla.; Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Fla.; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Fla.; and Florida Atlantic University, Boca Raton, Fla. IN - Hopkins, Elizabeth G. Hilton Becker Clinic of Plastic Surgery, Boca Raton, Fla.; Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Fla.; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Fla.; and Florida Atlantic University, Boca Raton, Fla. TI - Immediate Implant-based Prepectoral Breast Reconstruction Using a Vertical Incision. SO - Plastic and Reconstructive Surgery - Global Open. 3(6):e412, 2015 Jun AS - Plast. reconstr. surg., Glob. open. 3(6):e412, 2015 Jun NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 6 PG - e412 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494482 CP - United States AB - BACKGROUND: Ideally, breast reconstruction is performed at the time of mastectomy in a single stage with minimal scarring. However, postoperative complications with direct-to-implant subpectoral reconstruction remain significant. These include asymmetry, flap necrosis, animation deformity, and discomfort. We report on a series of patients who have undergone immediate single-stage prepectoral, implant-based breast reconstruction with a smooth, adjustable saline implant covered with mesh/acellular dermal matrix for support using a vertical mastectomy incision. This technique, when combined with an adjustable implant, addresses the complications related to subpectoral implant placement of traditional expanders. Our follow-up time, 4.6 years (55 months), shows a low risk of implant loss and elimination of animation deformity while also providing patients with a safe and aesthetically pleasing result. AB - METHODS: All patients who underwent immediate implant-based prepectoral breast reconstruction using a vertical mastectomy incision as a single-staged procedure were included. Charts were reviewed retrospectively. Adjustable smooth round saline implants and mesh/acellular dermal matrix were used for fixation in all cases. AB - RESULTS: Thirty-one patients (62 breasts) underwent single-staged implant-based prepectoral breast reconstruction using a vertical mastectomy incision. Postoperative complications occurred in 9 patients, 6 of which were resolved with postoperative intervention while only 2 cases resulted in implant loss. AB - CONCLUSIONS: There can be significant morbidity associated with traditional subpectoral implant-based breast reconstruction. As an alternative, the results of this study show that an immediate single-stage prepectoral breast reconstruction with a smooth saline adjustable implant, using a vertical incision, in conjunction with mesh/matrix support can be performed with excellent aesthetic outcomes and minimal complications. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000384 PT - Journal Article ID - 10.1097/GOX.0000000000000384 [doi] ID - PMC4494482 [pmc] PP - epublish PH - 2014/10/06 [received] PH - 2015/04/15 [accepted] LG - English EP - 20150708 DP - 2015 Jun EZ - 2015/07/17 06:00 DA - 2015/07/17 06:01 DT - 2015/07/17 06:00 YR - 2015 ED - 20150716 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26180713 <169. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26180710 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Macarios D AU - Griffin L AU - Chatterjee A AU - Lee LJ AU - Milburn C AU - Nahabedian MY FA - Macarios, David FA - Griffin, Leah FA - Chatterjee, Abhishek FA - Lee, Lauren J FA - Milburn, Cheryl FA - Nahabedian, Maurice Y IN - Macarios, David. LifeCell, an Acelity Company, Bridgewater, N.J.; Acelity, San Antonio, Tex.; Divisions of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Hospital, Philadelphia, Pa.; and Department of Plastic Surgery, Georgetown University, Washington, D.C. IN - Griffin, Leah. LifeCell, an Acelity Company, Bridgewater, N.J.; Acelity, San Antonio, Tex.; Divisions of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Hospital, Philadelphia, Pa.; and Department of Plastic Surgery, Georgetown University, Washington, D.C. IN - Chatterjee, Abhishek. LifeCell, an Acelity Company, Bridgewater, N.J.; Acelity, San Antonio, Tex.; Divisions of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Hospital, Philadelphia, Pa.; and Department of Plastic Surgery, Georgetown University, Washington, D.C. IN - Lee, Lauren J. LifeCell, an Acelity Company, Bridgewater, N.J.; Acelity, San Antonio, Tex.; Divisions of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Hospital, Philadelphia, Pa.; and Department of Plastic Surgery, Georgetown University, Washington, D.C. IN - Milburn, Cheryl. LifeCell, an Acelity Company, Bridgewater, N.J.; Acelity, San Antonio, Tex.; Divisions of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Hospital, Philadelphia, Pa.; and Department of Plastic Surgery, Georgetown University, Washington, D.C. IN - Nahabedian, Maurice Y. LifeCell, an Acelity Company, Bridgewater, N.J.; Acelity, San Antonio, Tex.; Divisions of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Hospital, Philadelphia, Pa.; and Department of Plastic Surgery, Georgetown University, Washington, D.C. TI - A Meta-analysis Assessing Postsurgical Outcomes between Aseptic and Sterile AlloDerm Regenerative Tissue Matrix. [Review] SO - Plastic and Reconstructive Surgery - Global Open. 3(6):e409, 2015 Jun AS - Plast. reconstr. surg., Glob. open. 3(6):e409, 2015 Jun NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 6 PG - e409 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494479 CP - United States AB - BACKGROUND: AlloDerm, a human acellular dermal matrix, is available in a ready-to-use (RTU) or freeze-dried (FD) form. A limited number of studies have compared complication rates between RTU and FD in implant-based breast reconstruction. The objective of this report was to conduct a meta-analysis of previously reported complication rates between RTU and FD. AB - METHODS: A systematic literature review was conducted from 2010 to 2014 and supplemented by hand searches. Included studies compared both RTU and FD. Odds ratios and relative risks (RRs) with 95% confidence interval (CI), taking into account study heterogeneity, were calculated. Studies reporting patient-level results as opposed to breast-level results were excluded from the primary analysis but included in subsequent sensitivity analyses. Variable follow-up time within and between studies was also considered in a sensitivity analysis. AB - RESULTS: Of the 275 identified studies, 115 studies were eligible for detailed review. Only 5 studies compared RTU with FD, and of these, 2 studies had breast-level data and 1 study had patient-level data appropriate for meta-analysis. The 2 studies included in the primary meta-analysis had a pooled sample size: n = 116 RTU and n = 109 FD patients, or 205 and 186 breasts, respectively. Age and body mass index were similar between groups. Across all meta-analyses, there were no differences in complication rates between RTU and FD: cellulitis (RR = 0.863; 95% CI, 0.272-2.740), seroma (RR = 0.553; 95% CI, 0.026-11.830), and explantation (RR = 0.593; 95% CI, 0.247-1.425). Results remained nonsignificant even after adjustment for variable follow-up time. AB - CONCLUSION: The results suggest that there are no differences in complication rates between RTU and FD forms. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000387 PT - Journal Article PT - Review ID - 10.1097/GOX.0000000000000387 [doi] ID - PMC4494479 [pmc] PP - epublish PH - 2015/02/19 [received] PH - 2015/04/16 [accepted] LG - English EP - 20150708 DP - 2015 Jun EZ - 2015/07/17 06:00 DA - 2015/07/17 06:01 DT - 2015/07/17 06:00 YR - 2015 ED - 20150716 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26180710 <170. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26161312 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lee J AU - Bae Y FA - Lee, Jeeyeon FA - Bae, Youngtae IN - Lee, Jeeyeon. 1 Department of Surgery, Breast Cancer Center, Kyungpook National University School of Medicine, Daegu, Republic of Korea ; 2 Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. IN - Bae, Youngtae. 1 Department of Surgery, Breast Cancer Center, Kyungpook National University School of Medicine, Daegu, Republic of Korea ; 2 Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. TI - Use of latissimus dorsi muscle onlay patch alternative to acellular dermal matrix in implant-based breast reconstruction. SO - Gland Surgery. 4(3):270-6, 2015 Jun AS - Gland surg.. 4(3):270-6, 2015 Jun NJ - Gland surgery VO - 4 IP - 3 PG - 270-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461708 CP - China (Republic : 1949- ) KW - Breast; latissimus dorsi muscle; reconstruction AB - BACKGROUND: An acellular dermal matrix (ADM) is applied to release the surrounding muscles and prevent dislocation or rippling of the implant. We compared implant-based breast reconstruction using the latissimus dorsi (LD) muscle, referred to as an "LD muscle onlay patch," with using an ADM. AB - METHOD: A total of 56 patients (60 breasts) underwent nipple sparing mastectomy with implant-based breast reconstruction using an ADM or LD muscle onlay patch. Cosmetic outcomes were assessed 4 weeks after chemotherapy or radiotherapy, and statistical analyses were performed. AB - RESULTS: Mean surgical time and hospital stay were significantly longer in the LD muscle onlay patch group than the ADM group. However, there were no statistically significant differences between groups in postoperative complications. Cosmetic outcomes for breast symmetry and shape were higher in the LD muscle onlay patch group. AB - CONCLUSIONS: Implant-based breast reconstruction with an LD muscle onlay patch would be a feasible alternative to using an ADM. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2015.01.07 PT - Journal Article ID - 10.3978/j.issn.2227-684X.2015.01.07 [doi] ID - gs-04-03-270 [pii] ID - PMC4461708 [pmc] PP - ppublish PH - 2014/11/29 [received] PH - 2014/12/30 [accepted] LG - English DP - 2015 Jun EZ - 2015/07/15 06:00 DA - 2015/07/15 06:01 DT - 2015/07/11 06:00 YR - 2015 ED - 20150710 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26161312 <171. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26161310 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Kaminsky AJ AU - Patel KM AU - Cocilovo C AU - Nahabedian MY AU - Miraliakbari R FA - Kaminsky, Alexander J FA - Patel, Ketan M FA - Cocilovo, Costanza FA - Nahabedian, Maurice Y FA - Miraliakbari, Reza IN - Kaminsky, Alexander J. 1 INOVA Fairfax Hospital, Falls Church, VA 22042, USA ; 2 Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA ; 3 Private Practice, Fairfax Virginia, USA. IN - Patel, Ketan M. 1 INOVA Fairfax Hospital, Falls Church, VA 22042, USA ; 2 Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA ; 3 Private Practice, Fairfax Virginia, USA. IN - Cocilovo, Costanza. 1 INOVA Fairfax Hospital, Falls Church, VA 22042, USA ; 2 Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA ; 3 Private Practice, Fairfax Virginia, USA. IN - Nahabedian, Maurice Y. 1 INOVA Fairfax Hospital, Falls Church, VA 22042, USA ; 2 Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA ; 3 Private Practice, Fairfax Virginia, USA. IN - Miraliakbari, Reza. 1 INOVA Fairfax Hospital, Falls Church, VA 22042, USA ; 2 Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA ; 3 Private Practice, Fairfax Virginia, USA. TI - The biplanar oncoplastic technique case series: a 2-year review. SO - Gland Surgery. 4(3):257-62, 2015 Jun AS - Gland surg.. 4(3):257-62, 2015 Jun NJ - Gland surgery VO - 4 IP - 3 PG - 257-62 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461703 CP - China (Republic : 1949- ) KW - Breast; breast reconstruction; lumpectomy; oncoplasty; partial mastectomy AB - BACKGROUND: Oncoplastic techniques for breast reconstruction following partial mastectomy are now commonly included in the armamentarium of most reconstructive plastic surgeons. These techniques have been frequently used for women with large breast volume and less frequently used form women with small to moderate breast volume. Most women with smaller breast volumes have been typically considered for mastectomy. As an alternative to mastectomy, the biplanar technique was designed and described as an oncoplastic option. The purpose of this manuscript is to review our 2-year experience using this technique in a series of women with small to moderate breast volume. AB - METHODS: A retrospective review of patients who underwent oncoplastic surgery from 2011-2012 by the senior authors (RM and MYN) was completed. Ten patients were identified that had the biplanar technique involving glandular tissue rearrangement in conjunction with the immediate placement of a submuscular implant or tissue expander. Patient demographics, perioperative details, and post-operative outcomes were evaluated. AB - RESULTS: The mean age and BMI of the ten patients in the study was 56 years (range, 40-68 years) and 24.1 years (range, 20.3-28.6 years) respectively. The mean resection volume was 76.5 g (range, 25-164 g). Eight patients had placement of a permanent implant and two patients had placement of a tissue expander. The average volume of the implanted devices was 138 cc (range, 90-300 cc). In eight patients, a sheet of acellular dermal matrix was used. Immediate biplanar reconstruction was performed in seven patients and a staged-immediate biplanar reconstruction was performed in three patients. Complications included a positive margin on final pathology requiring mastectomy (n=1), infection (n=1), incisional dehiscence following radiation (n=1), and loss of nipple sensation (n=2). Follow-up ranged from 4.5-27 months (mean of 19.5 months). AB - CONCLUSIONS: The biplanar oncoplastic technique may represent a valuable option in women with small to moderate breast volumes that choose to have breast conservation therapy (BCT). This technique has demonstrated success with minimizing contour irregularities and maintaining breast volume. Based on our early experience, patient satisfaction is favorable. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2015.04.07 PT - Journal Article ID - 10.3978/j.issn.2227-684X.2015.04.07 [doi] ID - gs-04-03-257 [pii] ID - PMC4461703 [pmc] PP - ppublish PH - 2015/01/08 [received] PH - 2015/03/25 [accepted] LG - English DP - 2015 Jun EZ - 2015/07/15 06:00 DA - 2015/07/15 06:01 DT - 2015/07/11 06:00 YR - 2015 ED - 20150710 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26161310 <172. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26161304 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Vu MM AU - Kim JY FA - Vu, Michael M FA - Kim, John Y S IN - Vu, Michael M. Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, USA. IN - Kim, John Y S. Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, USA. TI - Current opinions on indications and algorithms for acellular dermal matrix use in primary prosthetic breast reconstruction. [Review] SO - Gland Surgery. 4(3):195-203, 2015 Jun AS - Gland surg.. 4(3):195-203, 2015 Jun NJ - Gland surgery VO - 4 IP - 3 PG - 195-203 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461706 CP - China (Republic : 1949- ) KW - Breast reconstruction; acellular dermal matrix (ADM); algorithm AB - Acellular dermal matrix (ADM) is widely used in primary prosthetic breast reconstruction. Many indications and contraindications to use ADM have been reported in the literature, and their use varies by institution and surgeon. Developing rational, tested algorithms to determine when ADM is appropriate can significantly improve surgical outcomes and reduce costs associated with ADM use. We review the important indications and contraindications, and discuss the algorithms that have been put forth so far. Further research into algorithmic decision-making for ADM use will allow optimized balancing of cost with risk and benefit. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2015.05.07 PT - Journal Article PT - Review ID - 10.3978/j.issn.2227-684X.2015.05.07 [doi] ID - gs-04-03-195 [pii] ID - PMC4461706 [pmc] PP - ppublish PH - 2015/01/07 [received] PH - 2015/05/05 [accepted] GI - No: P30 CA060553 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2015 Jun EZ - 2015/07/15 06:00 DA - 2015/07/15 06:01 DT - 2015/07/11 06:00 YR - 2015 ED - 20150710 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26161304 <173. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24691314 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ganske I AU - Hoyler M AU - Fox SE AU - Morris DJ AU - Lin SJ AU - Slavin SA FA - Ganske, Ingrid FA - Hoyler, Marguerite FA - Fox, Sharon E FA - Morris, Donald J FA - Lin, Samuel J FA - Slavin, Sumner A IN - Ganske, Ingrid. From the *Harvard Combined Plastic Surgery Residency, Boston; +Harvard Medical School, Boston; ++Beth Israel Deaconess Medical Center Pathology Residency, Boston; and Division of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA. TI - Delayed hypersensitivity reaction to acellular dermal matrix in breast reconstruction: the red breast syndrome?. [Review] SO - Annals of Plastic Surgery. 73 Suppl 2:S139-43, 2014 Dec AS - Ann Plast Surg. 73 Suppl 2:S139-43, 2014 Dec NJ - Annals of plastic surgery VO - 73 Suppl 2 PG - S139-43 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - Erythema/di [Diagnosis] MH - *Erythema/et [Etiology] MH - Female MH - Humans MH - Hypersensitivity, Delayed/di [Diagnosis] MH - *Hypersensitivity, Delayed/et [Etiology] MH - Middle Aged MH - Postoperative Complications/di [Diagnosis] MH - *Postoperative Complications/et [Etiology] MH - Syndrome AB - BACKGROUND: Acellular dermal matrix (ADM) has become a valuable tool in reconstructive breast surgery, in part because it has been considered to be a non-reactive and non-immunogenic entity. However, some patients who undergo breast reconstruction with ADMs develop postoperative erythema overlying their ADM grafts. The etiology of this phenomenon is poorly understood. AB - METHODS: In this article, we summarize clinical cases in which patients developed localized breast erythema following reconstruction with ADMs. We review what is known about postoperative breast erythema after ADM-based breast reconstructions and the possible antigenicity of biologic mesh implants. AB - RESULTS: We report 4 implant-based breast reconstruction patients who developed erythematous reactions overlying the region where ADM was placed: one demonstrated a delayed-type hypersensitivity reaction on punch biopsy of the affected skin, leading to removal of the biologic product; 2 others had a similar clinical presentation that responded to corticosteroids without removal of the biologic material, with 1 patient experiencing recrudescence of erythema that responded fully to a second course of corticosteroids; and a fourth showed erythema that was only moderately responsive to antibiotic therapy but which improved consistently after the patient initiated chemotherapy. AB - CONCLUSION: We propose that the etiology of erythema overlying ADM grafts, and the so-called red breast syndrome, may in some patients be a delayed-type hypersensitivity reaction to the ADM product. Affected patients may benefit from treatment with corticosteroids or similar medications, and that such treatment may, in some cases, enable patients to retain the ADM grafts and enable salvage of the reconstructed breast. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000130 PT - Case Reports PT - Journal Article PT - Review ID - 10.1097/SAP.0000000000000130 [doi] PP - ppublish LG - English DP - 2014 Dec EZ - 2014/04/03 06:00 DA - 2015/07/07 06:00 DT - 2014/04/03 06:00 YR - 2014 ED - 20150706 RD - 20141115 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24691314 <174. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25811587 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kronowitz SJ FA - Kronowitz, Steven J IN - Kronowitz, Steven J. Houston, Texas From the Department of Plastic and Reconstructive Surgery, The University of Texas M. D. Anderson Cancer Center. TI - State of the art and science in postmastectomy breast reconstruction. SO - Plastic & Reconstructive Surgery. 135(4):755e-71e, 2015 Apr AS - Plast Reconstr Surg. 135(4):755e-71e, 2015 Apr NJ - Plastic and reconstructive surgery VO - 135 IP - 4 PG - 755e-71e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Algorithms MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - Surgical Flaps AB - LEARNING OBJECTIVES: After reading this article, the participant should be able to: 1. Examine clinicopathologic factors to determine the best timing for breast reconstruction. 2. Develop treatment plans for all patients for breast preserving reconstruction. 3. Determine the best approaches for partial and whole breast reconstruction. 4. Be familiar with advanced techniques in breast reconstruction. AB - BACKGROUND: Often, the decision to perform a partial or total mastectomy hinges on reconstructive issues, not oncology-related considerations. AB - METHODS: Innovative timing and reconstruction approaches are being implemented after partial mastectomy and breast reconstruction after mastectomy. AB - RESULTS: Among patients undergoing repair of a partial mastectomy defect, immediate or delayed repair before radiation allows for use of remaining breast tissue for repair. Innovative approaches include breast remodeling, local rotation advancement, and concentric mastopexy and breast reduction techniques to recontour remaining breast tissue. Delayed repair after whole-breast radiation usually is not preferred and is performed with autologous fat grafting or a flap. However, partial breast radiation allows for safe delayed repair after irradiation using the same techniques used for preradiation repair. The optimal timing for breast reconstruction after mastectomy remains a topic of controversy. Adjunct techniques for implant-based postmastectomy reconstruction include the use of acellular dermal matrix and autologous fat grafting, especially in the setting of radiation therapy. Techniques also include a more focused use of flaps only in the setting of radiation therapy with increasing use of new perforator-based autologous tissue flap options. AB - CONCLUSION: Innovative approaches to breast reconstruction have evolved to provide restorative healing for patients and hasten return to their modern, active lifestyles. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000001118 PT - Journal Article PT - Research Support, N.I.H., Extramural ID - 10.1097/PRS.0000000000001118 [doi] ID - 00006534-201504000-00035 [pii] PP - ppublish GI - No: CA016672 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2015 Apr EZ - 2015/03/27 06:00 DA - 2015/06/02 06:00 DT - 2015/03/27 06:00 YR - 2015 ED - 20150601 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25811587 <175. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26015888 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Caputo GG AU - Franchini Z AU - Maritan M AU - Dalla Pozza E AU - Vigato E AU - Tedeschi U AU - Governa M FA - Caputo, Glenda Giorgia FA - Franchini, Zeno FA - Maritan, Monia FA - Dalla Pozza, Edoardo FA - Vigato, Enrico FA - Tedeschi, Umberto FA - Governa, Maurizio IN - Caputo, Glenda Giorgia. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Franchini, Zeno. General Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Maritan, Monia. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Dalla Pozza, Edoardo. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Vigato, Enrico. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Tedeschi, Umberto. General Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Governa, Maurizio. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. TI - Daily serum collection after acellular dermal matrix-assisted breast reconstruction. SO - Archives of Plastic Surgery. 42(3):321-6, 2015 May AS - Arch. plast. surg.. 42(3):321-6, 2015 May NJ - Archives of plastic surgery VO - 42 IP - 3 PG - 321-6 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439592 CP - Korea (South) KW - Acellular dermis; Inflammation; Mammaplasty; Mastectomy; Seroma AB - BACKGROUND: The acellular dermal matrix (ADM)-assisted breast reconstruction technique is widely known, but discouraging results due to early postoperative complications have been reported. As the literature identifies seroma as the most common issue after breast surgery without identifying its pathogenesis, we aimed to report the trend of postoperative daily serum collection after ADM-assisted breast reconstruction and compare it with data in the literature in order to discover more about this little-known topic. AB - METHODS: A retrospective study on 28 consecutive patients who received ADM-assisted breast reconstruction between February 2013 and February 2014 was performed. In order to reduce the number of variables that could affect serum production, only one brand of ADM was used and all tissues were handled gently and precisely. The daily drainage volume was recorded per patient during the first four days of hospitalization. Likewise, postoperative complications were noted during routine follow-up. AB - RESULTS: In total, five (17.9%) bilateral and 23 (82.1%) unilateral ADM-assisted breast reconstructions (33 implants) were performed. The mean age, body mass index, and length of hospital stay were 53.6 years, 21.3 kg/m(2), and 4.5 days, respectively. One major complication led to implant loss (3.0%), and nine minor complications were successfully treated with ambulatory surgery (27.3%). Serum collection linearly decreased after 24 hours postoperatively. AB - CONCLUSIONS: Daily drainage decreased following the theoretical decline of acute inflammation. In concordance with the literature, daily serum production may not be related to the use of ADM. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2015.42.3.321 PT - Journal Article ID - 10.5999/aps.2015.42.3.321 [doi] ID - PMC4439592 [pmc] PP - ppublish PH - 2014/09/05 [received] PH - 2014/11/05 [revised] PH - 2014/11/05 [accepted] LG - English EP - 20150514 DP - 2015 May EZ - 2015/05/28 06:00 DA - 2015/05/28 06:01 DT - 2015/05/28 06:00 YR - 2015 ED - 20150527 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26015888 <176. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26015887 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Kim SY AU - Lim SY AU - Mun GH AU - Bang SI AU - Oh KS AU - Pyon JK FA - Kim, So-Young FA - Lim, So Young FA - Mun, Goo-Hyun FA - Bang, Sa-Ik FA - Oh, Kap Sung FA - Pyon, Jai-Kyong IN - Kim, So-Young. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. IN - Lim, So Young. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. IN - Mun, Goo-Hyun. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. IN - Bang, Sa-Ik. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. IN - Oh, Kap Sung. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. IN - Pyon, Jai-Kyong. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. TI - Evaluating the effectiveness of cryopreserved acellular dermal matrix in immediate expander-based breast reconstruction: a comparison study. SO - Archives of Plastic Surgery. 42(3):316-20, 2015 May AS - Arch. plast. surg.. 42(3):316-20, 2015 May NJ - Archives of plastic surgery VO - 42 IP - 3 PG - 316-20 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439591 CP - Korea (South) KW - Acelluar dermis; Seroma; Tissue expander devices AB - BACKGROUND: CGCryoDerm was first introduced in 2010 and offers a different matrix preservation processes for freezing without drying preparation. From a theoretical perspective, CGCryoDerm has a more preserved dermal structure and more abundant growth factors for angiogenesis and recellularization. In the current study, the authors performed a retrospective study to evaluate freezing- and freeze-drying-processed acellular dermal matrix (ADM) to determine whether any differences were present in an early complication profile. AB - METHODS: Patients who underwent ADM-assisted tissue expander placement for two stage breast reconstruction between January of 2013 and March of 2014 were retrospectively reviewed and divided into two groups based on the types of ADM-assisted expander reconstruction (CGDerm vs. CGCryoDerm). Complications were divided into four main categories and recorded as follows: seroma, hematoma, infection, and mastectomy skin flap necrosis. AB - RESULTS: In a total of 82 consecutive patients, the CGCryoDerm group had lower rates of seroma when compared to the CGDerm group without statistical significance (3.0% vs. 10.2%, P=0.221), respectively. Other complications were similar in both groups. Reconstructions with CGCryoDerm were found to have a significantly longer period of drainage when compared to reconstructions with CGDerm (11.91 days vs. 10.41 days, P=0.043). AB - CONCLUSIONS: Preliminary findings indicate no significant differences in early complications between implant/expander-based reconstructions using CGCryoderm and those using CGDerm. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2015.42.3.316 PT - Journal Article ID - 10.5999/aps.2015.42.3.316 [doi] ID - PMC4439591 [pmc] PP - ppublish PH - 2014/10/08 [received] PH - 2014/11/22 [revised] PH - 2014/12/03 [accepted] LG - English EP - 20150514 DP - 2015 May EZ - 2015/05/28 06:00 DA - 2015/05/28 06:01 DT - 2015/05/28 06:00 YR - 2015 ED - 20150527 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26015887 <177. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25909549 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Zikiriakhodzhaev AD AU - Ermoshchenkova MV FA - Zikiriakhodzhaev, A D FA - Ermoshchenkova, M V IN - Zikiriakhodzhaev, A D. Moskovskii nauchno-issledovatel'skii onkologicheskii institut im. P.A. Gertsena Minzdrava Rossii, Moskva. IN - Ermoshchenkova, M V. Moskovskii nauchno-issledovatel'skii onkologicheskii institut im. P.A. Gertsena Minzdrava Rossii, Moskva. TI - [Biological implant in single-stage reconstruction of mammary gland for cancer]. [Review] [Russian] SO - Khirurgiia. (1):35-40, 2015 AS - Khirurgiia (Mosk). (1):35-40, 2015 NJ - Khirurgiia IP - 1 PG - 35-40 PI - Journal available in: Print PI - Citation processed from: Print JC - kv3, 0412765 IO - Khirurgiia (Mosk) SB - Index Medicus CP - Russia (Federation) MH - *Acellular Dermis MH - Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - *Breast Implantation MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - *Mammaplasty MH - Mastectomy/mt [Methods] MH - Patient Outcome Assessment MH - Postoperative Complications/cl [Classification] MH - *Postoperative Complications/pc [Prevention & Control] MH - Skin Transplantation/ae [Adverse Effects] MH - Skin Transplantation/mt [Methods] AB - Brief literature review about features of biological implants application for mammary gland reconstruction is presented in the article. Possible complications after such materials use, first experience of acellular dermal matrix administration for single-stage mammary gland reconstruction in 6 patients with breast cancer are also described. We offered surgical techniques, complications and methods of its treatment. We presented advantages of biological implant use which are consisted in decrease of surgical damage and duration of surgery, opportunity for enlargement of pocket for implant, decrease of pain syndrome. OA - Publisher: B cTaTbe pedcTaBeHbl kpaTk ob3op TepaTypbl, ocBeHHo ocobeHHocTM cob3oBaH booeckx MaHTaToB p pekoHcTpyk MooHo ee3bl, Bo3MoHble ocoHeH pMeHeH Tx MaTepaoB, epBbl cobcTBeHHbl oblT pMeHeH aeyupHoo depMabHoo MaTpkca p odHoMoMeHTHo pekoHcTpyk MooHo ee3bl y 6 bobHblx pakoM MooHo ee3bl. OcaHbl MeTodka oepa, ocoHeH MeTodbl x eeH. Uka3aHbl peMyecTBa pMeHeH booeckoo MaTpkca, 3akyuayuec B cHeH TpaBMaTHocT oepaTBHoo BMeaTebcTBa p odHoMoMeHTHo pekoHcTpyk, cokpaeH dTebHocT oepa, Bo3MoHocT pacpeH kapMaHa d HdopoTe3a, cHeH BblpaeHHocT boeBoo cHdpoMa.; Language: Russian IS - 0023-1207 IL - 0023-1207 DO - https://dx.doi.org/10.17116/hirurgia22015135-40 PT - English Abstract PT - Journal Article PT - Review PP - ppublish LG - Russian DP - 2015 EZ - 2015/04/25 06:00 DA - 2015/05/27 06:00 DT - 2015/04/25 06:00 YR - 2015 ED - 20150526 RD - 20170614 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25909549 <178. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25620484 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chen Y AU - Chen J AU - Chen J AU - Yang B AU - Li L AU - Huang X AU - Shao Z AU - Shen Z AU - Yu P AU - Wu J FA - Chen, Ying FA - Chen, Jiajian FA - Chen, Jiaying FA - Yang, Benlong FA - Li, Lin FA - Huang, Xiaoyan FA - Shao, Zhimin FA - Shen, Zhenzhou FA - Yu, Peirong FA - Wu, Jiong IN - Chen, Ying. Department of Breast Surgery, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. IN - Wu, Jiong. Email: wujiong1122@vip.sina.com. TI - [Current trends of breast reconstruction after mastectomy for breast cancer patients in China: a survey report]. [Chinese] SO - Chung-Hua Chung Liu Tsa Chih [Chinese Journal of Oncology]. 36(11):851-7, 2014 Nov AS - Chung Hua Chung Liu Tsa Chih. 36(11):851-7, 2014 Nov NJ - Zhonghua zhong liu za zhi [Chinese journal of oncology] VO - 36 IP - 11 PG - 851-7 PI - Journal available in: Print PI - Citation processed from: Print JC - ebh, 7910681 IO - Zhonghua Zhong Liu Za Zhi SB - Index Medicus CP - China MH - Breast Neoplasms/ep [Epidemiology] MH - *Breast Neoplasms/su [Surgery] MH - China/ep [Epidemiology] MH - Humans MH - Mammaplasty MH - *Mastectomy/td [Trends] MH - Postoperative Complications MH - Postoperative Period MH - Quality of Life MH - Reconstructive Surgical Procedures MH - Surgical Flaps MH - Surveys and Questionnaires AB - OBJECTIVE: To explore the current trends of breast reconstruction (BR) for breast cancer patients in China. AB - METHODS: A questionnaire was designed for this study, and it included questions on surgeon demographics, number of mastectomy and BR, type and timing of BR, reconstructive choices in the setting of preoperative or postoperative radiotherapy or chemotherapy, etc. All data were collected until December 2012. Questionnaires were sent to 52 members of the Committee of Breast Cancer Society by e-mail or mail. AB - RESULTS: By July 2013, 41 questionnaires had been returned. Among all, 5 were excluded for not performing BR. These 36 hospitals covered 22 provinces and municipalities in China. A total of 538 surgeons working in the general surgery or oncological surgery department, but only 123 (22.9%) were qualified to perform BR. In 2012, except for 4 missing data, 24, 763 mastectomies were performed in 32 hospitals; among them, 1120 (4.5%) received BR. According to these 36 respondents, 32 (88.9%) performed prosthetic (1, 843 cases in all) while 4 (11.1%) performed prosthetic BR with acellular dermal matrix (17 cases in all) from the time of their first BR operation to the end of 2012. During the same period, 965 latissimus dorsi myocutaneous flaps with implant were performed in 23 (63.9%) hospitals while 738 latissimus dorsi myocutaneous flaps without implant were performed in 32 (88.9%) hospitals. At the same time, 366 pedicled transverse rectus abdominis myocutaneous flap BRs were performed in 28 (77.8%) hospitals, while 155 abdominal free flap BRs were carried out in 9 (25.0%) hospitals. The overall complication rate was 18.2%. Postoperative radiotherapy had some effect on influencing the esthetic outcomes of BR, so the autologous BR was recommended, but the timing remained controversial. Regarding chemotherapy, most respondents concluded that it had no effect or only a mild effect. The overall cosmetic outcomes of the reconstructed breasts satisfied the majority of physicians and patients. AB - CONCLUSIONS: With more attention paid to the quality of life after mastectomy, more and more BRs are needed, but the ratio is still low in China. To improve this situation, more efforts are needed, including the improvement of the intrahospital framework of multi-disciplinary service, the training for doctors and the educational program for patients, etc. IS - 0253-3766 IL - 0253-3766 PT - English Abstract PT - Journal Article PP - ppublish LG - Chinese DP - 2014 Nov EZ - 2015/01/27 06:00 DA - 2015/05/21 06:00 DT - 2015/01/27 06:00 YR - 2014 ED - 20150520 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25620484 <179. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25041092 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Parvizi D AU - Haas F AU - Peintinger F AU - Hubmer M AU - Rappl T AU - Koch H AU - Schintler M AU - Spendel S AU - Kamolz LP AU - Wurzer P AU - Tuca A AU - Fuchsjaeger M AU - Weinke R FA - Parvizi, Daryousch FA - Haas, Franz FA - Peintinger, Florentia FA - Hubmer, Martin FA - Rappl, Thomas FA - Koch, Horst FA - Schintler, Michael FA - Spendel, Stephan FA - Kamolz, Lars-Peter FA - Wurzer, Paul FA - Tuca, Alexandru FA - Fuchsjaeger, Michael FA - Weinke, Roland IN - Parvizi, Daryousch. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria. TI - First experience using contrast-enhanced ultrasound to evaluate vascularisation of acellular dermal matrices after implant-based breast reconstruction. SO - Breast Journal. 20(5):461-7, 2014 Sep-Oct AS - Breast J. 20(5):461-7, 2014 Sep-Oct NJ - The breast journal VO - 20 IP - 5 PG - 461-7 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast/bs [Blood Supply] MH - *Breast Implantation MH - Breast Implants MH - Contrast Media MH - Female MH - Humans MH - *Mastectomy MH - Middle Aged MH - Retrospective Studies MH - Treatment Outcome MH - Ultrasonography, Mammary MH - Wound Healing KW - ADM; CEUS; IBBR; NSM; SSM; breast reconstruction; mastectomy AB - UNLABELLED: Acellular dermal matrices (ADM) have been used frequently in therapeutic and prophylactic breast procedures. To date there have been no reports on vascularisation of ADMs and formation of tissue around them as seen with modern non-invasive imaging techniques such as contrast-enhanced ultrasound (CEUS). In this case series, we used CEUS to investigate the features of ADM in relation to vascular ingrowth and scaffold for "new" tissue formation. This is a retrospective evaluation of patients who underwent successful skin- and nipple-sparing mastectomy (SSM, NSM) with immediate IBBR using ADM from May 31, 2010, through December 28, 2012. Over a 24-month period, 16 patients, with an average age of 44 years (range 27-70 years), were evaluated with CEUS. No contrast agent allergies or side effects were reported for the ultrasound examination. After contrast agent injection (1-18 months postoperatively), homogeneous normal enhancement in the ADM and peripheral region with physiological tissue formation was seen in all patients. In this small study, the most obvious contribution of CEUS is the in vivo evaluation of vascular ingrowth and tissue formation after IBBR with ADM after follow-up of 1-18 months postoperatively. AB - LEVEL OF EVIDENCE III: Retrospective cohort or comparative study; case-control study; or systematic review of these studies. Copyright © 2014 Wiley Periodicals, Inc. RN - 0 (Contrast Media) ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12301 PT - Journal Article ID - 10.1111/tbj.12301 [doi] PP - ppublish LG - English EP - 20140707 DP - 2014 Sep-Oct EZ - 2014/07/22 06:00 DA - 2015/05/15 06:00 DT - 2014/07/22 06:00 YR - 2014 ED - 20150514 RD - 20140904 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25041092 <180. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25973359 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Ibrahim AM AU - Koolen PG AU - Ashraf AA AU - Kim K AU - Mureau MA AU - Lee BT AU - Lin SJ FA - Ibrahim, Ahmed M S FA - Koolen, Pieter G L FA - Ashraf, Azra A FA - Kim, Kuylhee FA - Mureau, Marc A M FA - Lee, Bernard T FA - Lin, Samuel J IN - Ibrahim, Ahmed M S. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. IN - Koolen, Pieter G L. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. IN - Ashraf, Azra A. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. IN - Kim, Kuylhee. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. IN - Mureau, Marc A M. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. IN - Lee, Bernard T. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. IN - Lin, Samuel J. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.; and Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. TI - Acellular Dermal Matrix in Reconstructive Breast Surgery: Survey of Current Practice among Plastic Surgeons. SO - Plastic and Reconstructive Surgery - Global Open. 3(4):e381, 2015 Apr AS - Plast. reconstr. surg., Glob. open. 3(4):e381, 2015 Apr NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 4 PG - e381 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422212 CP - United States AB - BACKGROUND: Acellular dermal matrices (ADMs) in plastic surgery have become increasingly popular particularly for breast reconstruction. Despite their advantages, questions exist regarding their association with a possible increased incidence of complications. We describe a collective experience of plastic surgeons' use of ADMs in reconstructive breast surgery using an internet-based survey. AB - METHODS: Members of the American Society of Plastic Surgeons were recruited through voluntary, anonymous participation in an online survey. The web-based survey garnered information about participant demographics and their experience with ADM use in breast reconstruction procedures. After responses were collected, all data were anonymously processed. AB - RESULTS: Data were ascertained through 365 physician responses of which 99% (n = 361) completed the survey. The majority of participants were men (84.5%) between 51 and 60 years (37.4%); 84.2% used ADM in breast reconstruction, including radiated patients (79.7%). ADM use was not favored for nipple reconstruction (81.5%); 94.6% of participants used drains, and 87.8% administered antibiotics postoperatively. The most common complications were seroma (70.9%) and infection (16%), although 57.4% claimed anecdotally that overall complication rate was unchanged after incorporating ADM into their practice. High cost was a deterrent for ADM use (37.5%). AB - CONCLUSIONS: Plastic surgeons currently use ADM in breast reconstruction for both immediate and staged procedures. Of those responding, a majority of plastic surgeons will incorporate drains and use postoperative antibiotics for more than 48 hours. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000148 PT - Journal Article ID - 10.1097/GOX.0000000000000148 [doi] ID - PMC4422212 [pmc] PP - epublish PH - 2014/06/13 [received] PH - 2015/03/30 [accepted] LG - English EP - 20150507 DP - 2015 Apr EZ - 2015/05/15 06:00 DA - 2015/05/15 06:01 DT - 2015/05/15 06:00 YR - 2015 ED - 20150514 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25973359 <181. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24907100 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kim YW AU - Kim YJ AU - Kong JS AU - Cheon YW FA - Kim, Yang Woo FA - Kim, Yoon Ji FA - Kong, Jung Sik FA - Cheon, Young Woo IN - Kim, Yang Woo. Department of Plastic and Reconstructive Surgery, Gachon University Gil Medical Center, School of Medicine, Gachon University, 1198 Guwol-Dong, Namdong-Gu, Incheon, 405-760, Korea. TI - Use of the pectoralis major, serratus anterior, and external oblique fascial flap for immediate one-stage breast reconstruction with implant. SO - Aesthetic Plastic Surgery. 38(4):704-10, 2014 Aug AS - Aesthetic Plast Surg. 38(4):704-10, 2014 Aug NJ - Aesthetic plastic surgery VO - 38 IP - 4 PG - 704-10 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Breast Implantation/mt [Methods] MH - *Composite Tissue Allografts MH - Humans MH - Patient Selection MH - Quality of Life AB - BACKGROUND: Skin- or nipple-sparing mastectomy facilitates immediate one-stage reconstruction with an implant. Traditionally, an acellular dermal matrix or a muscle flap has been used because the inferolateral portion of the implant cannot be covered by the pectoralis major muscle. However, this method has drawbacks, including infection, cost, and donor-site morbidity. Therefore, we used an autologous conjoined fascial flap composed of the pectoralis major, serratus anterior, and external oblique fascia in patients with small-to-medium breasts. AB - METHODS: A series of 11 immediate breast reconstructions in 11 patients was carried out from March 2010 to June 2011. The conjoined fascial flap and smooth round implants were used in all patients. Postoperative photographs were evaluated by a blinded panel and scored on a four-point scale. Patient satisfaction was evaluated by a postoperative questionnaire that had five items designed to evaluate quality of life with the reconstruction. AB - RESULTS: The mean body mass index was 23.2 kg/m(2), follow-up period was 30.9 months, and implant volume was 286.3 cc. Regarding complications, we observed one case of partial skin flap necrosis and one case of seroma accumulation in the axilla, both of which healed with conservative care. The mean overall breast satisfaction score was 3.18 +/- 0.5. AB - CONCLUSIONS: The conjoined fascial flap is a viable alternative for immediate one-stage breast reconstruction with an implant. We recommend appropriate patient selection with a body mass index greater than 20 kg/m(2) and small-to-medium sized nonptotic breasts. AB - LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-014-0351-1 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1007/s00266-014-0351-1 [doi] PP - ppublish PH - 2014/02/08 [received] PH - 2014/05/05 [accepted] LG - English EP - 20140607 DP - 2014 Aug EZ - 2014/06/08 06:00 DA - 2015/04/25 06:00 DT - 2014/06/08 06:00 YR - 2014 ED - 20150424 RD - 20140722 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24907100 <182. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25626807 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gfrerer L AU - Mattos D AU - Mastroianni M AU - Weng QY AU - Ricci JA AU - Heath MP AU - Lin A AU - Specht MC AU - Haynes AB AU - Austen WG Jr AU - Liao EC FA - Gfrerer, Lisa FA - Mattos, David FA - Mastroianni, Melissa FA - Weng, Qing Y FA - Ricci, Joseph A FA - Heath, Martha P FA - Lin, Alex FA - Specht, Michelle C FA - Haynes, Alex B FA - Austen, William G Jr FA - Liao, Eric C IN - Gfrerer, Lisa. Boston, Mass. From the Division of Plastic and Reconstructive Surgery, the Division of Surgical Oncology, and the Codman Center for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Harvard Medical School; and the Center for Regenerative Medicine, Harvard Stem Cell Institute. TI - Assessment of patient factors, surgeons, and surgeon teams in immediate implant-based breast reconstruction outcomes. [Review] SO - Plastic & Reconstructive Surgery. 135(2):245e-52e, 2015 Feb AS - Plast Reconstr Surg. 135(2):245e-52e, 2015 Feb NJ - Plastic and reconstructive surgery VO - 135 IP - 2 PG - 245e-52e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Breast/pa [Pathology] MH - Breast Implantation/mt [Methods] MH - *Breast Implantation/sn [Statistics & Numerical Data] MH - Breast Neoplasms/ep [Epidemiology] MH - Breast Neoplasms/su [Surgery] MH - Breast Neoplasms/th [Therapy] MH - Combined Modality Therapy MH - Comorbidity MH - Cooperative Behavior MH - Female MH - Humans MH - Logistic Models MH - Mammaplasty/mt [Methods] MH - *Mammaplasty/sn [Statistics & Numerical Data] MH - Mastectomy/mt [Methods] MH - *Mastectomy/sn [Statistics & Numerical Data] MH - *Medical Oncology/sn [Statistics & Numerical Data] MH - Necrosis/pa [Pathology] MH - Obesity/ep [Epidemiology] MH - Odds Ratio MH - *Patient Care Team/sn [Statistics & Numerical Data] MH - Patient Selection MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pa [Pathology] MH - Prosthesis-Related Infections/ep [Epidemiology] MH - Prosthesis-Related Infections/su [Surgery] MH - Retrospective Studies MH - Smoking MH - *Surgery, Plastic/sn [Statistics & Numerical Data] MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/su [Surgery] MH - Tertiary Care Centers/sn [Statistics & Numerical Data] MH - Treatment Outcome AB - BACKGROUND: Outcome studies of immediate implant-based breast reconstruction have focused largely on patient factors, whereas the relative impact of the surgeon as a contributing variable is not known. As the procedure requires collaboration of both a surgical oncologist and a plastic surgeon, the effect of the surgeon team interaction can have a significant impact on outcome. This study examines outcomes in implant-based breast reconstruction and the association with patient characteristics, surgeon, and surgeon team familiarity. AB - METHODS: A retrospective review of 3142 consecutive implant-based breast reconstruction mastectomy procedures at one institution was performed. Infection and skin necrosis rates were measured. Predictors of outcomes were identified by unadjusted logistic regression followed by multivariate logistic regression. Surgeon teams were grouped according to number of cases performed together. AB - RESULTS: Patient characteristics remain the most important predictors for outcomes in implant-based breast reconstruction, with odds ratios above those of surgeon variables. The authors observed significant differences in the rate of skin necrosis between surgical oncologists with an approximately two-fold difference between surgeons with the highest and lowest rates. Surgeon teams that worked together on fewer than 150 procedures had higher rates of infection. AB - CONCLUSIONS: Patient characteristics are the most important predictors for surgical outcomes in implant-based breast reconstruction, but surgeons and surgeon teams are also important variables. High-volume surgeon teams achieve lower rates of infection. This study highlights the need to examine modifiable risk factors associated with optimum implant-based breast reconstruction outcomes, which include patient and provider characteristics and the surgical team treating the patient. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000912 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000000912 [doi] ID - 00006534-201502000-00005 [pii] PP - ppublish LG - English DP - 2015 Feb EZ - 2015/01/30 06:00 DA - 2015/04/18 06:00 DT - 2015/01/29 06:00 YR - 2015 ED - 20150417 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25626807 <183. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25502862 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fine NA AU - Lehfeldt M AU - Gross JE AU - Downey S AU - Kind GM AU - Duda G AU - Kulber D AU - Horan R AU - Ippolito J AU - Jewell M FA - Fine, Neil A FA - Lehfeldt, Max FA - Gross, John E FA - Downey, Susan FA - Kind, Gabriel M FA - Duda, Gloria FA - Kulber, David FA - Horan, Rebecca FA - Ippolito, Jeff FA - Jewell, Mark IN - Fine, Neil A. Chicago, Ill.; South Pasadena, Los Angeles, and San Francisco, Calif.; McLean, Va.; Medford, Mass.; and Portland and Eugene, Ore. From the Northwestern Specialists in Plastic Surgery; private practice; University of Southern California Keck School of Medicine; California-Pacific Medical Center; Aesthetic Center for Plastic Surgery; Cedars Sinai Medical Center; Silk Therapeutics, Inc.; and Oregon Health Science University. TI - SERI surgical scaffold, prospective clinical trial of a silk-derived biological scaffold in two-stage breast reconstruction: 1-year data. SO - Plastic & Reconstructive Surgery. 135(2):339-51, 2015 Feb AS - Plast Reconstr Surg. 135(2):339-51, 2015 Feb NJ - Plastic and reconstructive surgery VO - 135 IP - 2 PG - 339-51 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Combined Modality Therapy MH - Equipment Failure MH - Female MH - Follow-Up Studies MH - Hematoma/ep [Epidemiology] MH - Hematoma/et [Etiology] MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - Male MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/is [Instrumentation] MH - Mammaplasty/mt [Methods] MH - Mastitis/ep [Epidemiology] MH - Middle Aged MH - Patient Satisfaction MH - Postoperative Complications/ep [Epidemiology] MH - Prospective Studies MH - Radiotherapy, Adjuvant MH - Seroma/ep [Epidemiology] MH - Seroma/et [Etiology] MH - Silk MH - Surgical Mesh/ae [Adverse Effects] MH - *Surgical Mesh MH - Surgical Wound Infection/ep [Epidemiology] MH - Tissue Expansion Devices MH - Tissue Scaffolds/ae [Adverse Effects] MH - *Tissue Scaffolds AB - BACKGROUND: SERI Surgical Scaffold is a long-term bioresorbable silk-derived biological scaffold developed to provide soft-tissue support and repair. AB - METHODS: SURE-001 (ClinicalTrials.gov identification no. NCT01256502) is a prospective, single-arm study in the United States of patients undergoing two-stage, implant-based breast reconstruction using SERI. AB - RESULTS: A total of 139 patients were enrolled and will be followed for 2 years; in this article, the authors report interim data on 71 patients followed for 1 year. Investigator satisfaction scores (mean +/- SD) at 6 and 12 months were 9.2 +/- 0.98 and 9.4 +/- 0.91, respectively (10 = very satisfied). SERI was rated easy/very easy to use in 98 percent or more of cases across five categories in stage I surgery. Patient satisfaction with the treated breast(s) (mean +/- SD) was higher at 6 (4.3 +/- 0.87; 5 = very satisfied) and 12 months (4.5 +/- 0.82) compared with screening (3.6 +/- 1.09; p < 0.0001). Key complication rates (per breast) were tissue necrosis (6.7 percent), seroma (5.7 percent), hematoma (4.8 percent), implant loss (3.8 percent), capsular contracture (1.9 percent), and breast infection (1.0 percent). None were attributed to SERI by the investigators. In 13 patients (14 breasts) who underwent unplanned radiation therapy, one complication was reported. AB - CONCLUSIONS: In this interim report, high levels of investigator and patient satisfaction, and ease of use of SERI were reported. Prospectively collected complication rates were similar to those reported in primarily retrospective studies of two-stage, implant-based breast reconstructions using other implantable soft-tissue support materials such as acellular dermal matrices. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 0 (Silk) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000987 PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0000000000000987 [doi] PP - ppublish SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT01256502 SL - https://clinicaltrials.gov/search/term=NCT01256502 LG - English DP - 2015 Feb EZ - 2014/12/17 06:00 DA - 2015/04/18 06:00 DT - 2014/12/16 06:00 YR - 2015 ED - 20150417 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25502862 <184. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25878928 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Wilson HB FA - Wilson, Henry B IN - Wilson, Henry B. Division of Plastic Surgery, Centra Health, Lynchburg, Va. TI - Early Results Show Reduced Infection Rate Using No-touch Technique for Expander/ADM Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 3(3):e317, 2015 Mar AS - Plast. reconstr. surg., Glob. open. 3(3):e317, 2015 Mar NJ - Plastic and reconstructive surgery. Global open VO - 3 IP - 3 PG - e317 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387139 CP - United States AB - Infection is a common complication of immediate breast reconstruction that often leads to device removal, a result emotionally devastating to the patient and frustrating for her surgeon. "No-touch" techniques have been used in other surgical disciplines and plastic surgery, but they have not been reported for breast reconstruction with tissue expanders or implants and acellular dermis. We report a novel technique of tissue expander and acellular dermis placement using no-touch principles with a self-retaining retractor system that holds promise to decrease infectious complications of breast reconstruction. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000294 PT - Journal Article ID - 10.1097/GOX.0000000000000294 [doi] ID - PMC4387139 [pmc] PP - epublish PH - 2014/10/06 [received] PH - 2015/01/27 [accepted] LG - English EP - 20150407 DP - 2015 Mar EZ - 2015/04/17 06:00 DA - 2015/04/17 06:01 DT - 2015/04/17 06:00 YR - 2015 ED - 20150416 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25878928 <185. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24355452 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gunnarsson GL AU - Borsen-Koch M AU - Arffmann S AU - Guldvog I AU - Wamberg P AU - Kjaer C AU - Westvik T AU - Thomsen JB FA - Gunnarsson, Gudjon Leifur FA - Borsen-Koch, Mikkel FA - Arffmann, Susanne FA - Guldvog, Ivar FA - Wamberg, Peter FA - Kjaer, Christina FA - Westvik, Tormod FA - Thomsen, Jorn Bo IN - Gunnarsson, Gudjon Leifur. Plastikkirurgisk Afdeling Z, Vejle Sygehus, Kabbeltoft 25, 7100 Vejle, Denmark. jbth@dadlnet.dk. TI - Successful breast reconstruction using acellular dermal matrix can be recommended in healthy non-smoking patients. SO - Danish Medical Journal. 60(12):A4751, 2013 Dec AS - Dan Med J. 60(12):A4751, 2013 Dec NJ - Danish medical journal VO - 60 IP - 12 PG - A4751 PI - Journal available in: Print PI - Citation processed from: Internet JC - 101576205 IO - Dan Med J SB - Index Medicus CP - Denmark MH - *Acellular Dermis MH - Adult MH - Age Factors MH - Aged MH - Breast Neoplasms/co [Complications] MH - *Breast Neoplasms/th [Therapy] MH - Chemotherapy, Adjuvant MH - Female MH - Humans MH - *Hypertension/co [Complications] MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Segmental MH - Middle Aged MH - Necrosis/et [Etiology] MH - Radiotherapy, Adjuvant MH - Retrospective Studies MH - *Smoking/ae [Adverse Effects] MH - Surgical Wound Dehiscence/et [Etiology] MH - Surgical Wound Infection/et [Etiology] MH - Time Factors MH - Treatment Failure MH - Treatment Outcome AB - INTRODUCTION: We present Scandinavia's first series of immediate alloplastic breast reconstructions with an acellular dermal matrix. AB - MATERIAL AND METHODS: Data were collected retrospectively in 76 cases of immediate breast reconstruction using an acellular dermal matrix (ADM) and an implant. AB - RESULTS: A total of 59 women were reconstructed between June 2011 and January 2013. Cases included 42 unilateral and 17 bilateral reconstructions. A large number of patients had adjuvant therapy, hormone therapy (34), radiation therapy (27) or chemotherapy (38). The median age was 51 years (30-70 years) and the median follow-up period was 326 days (68-624 days). The co-morbidity factors included hypertension (n = 11), diabetes (n = 2) and 19 patients were smokers. Unsuccessful reconstructions counted ten cases (13%), eight of these due to necrosis and/or wound dehiscence (10%) and two due to infection (3%). The failure rate in non-smokers was 2/52 (4%) compared with 8/24 (33%) in smokers, p = 0.001. In hypertensive patients, the failure rate was 6/12 (50%) compared with 4/64 (6%)in normotensive patients, p = 0.001. 70% of the failed reconstructions occurred in patients older than 65 years of age. AB - CONCLUSION: Immediate alloplastic breast reconstruction using an ADM can be recommended to healthy non-smoking patients. AB - FUNDING: not relevant. AB - TRIAL REGISTRATION: not relevant. ES - 2245-1919 IL - 2245-1919 PT - Journal Article ID - A4751 [pii] PP - ppublish LG - English DP - 2013 Dec EZ - 2013/12/21 06:00 DA - 2015/04/14 06:00 DT - 2013/12/21 06:00 YR - 2013 ED - 20150413 RD - 20131220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24355452 <186. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24491626 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ortiz JA FA - Ortiz, Juan A IN - Ortiz, Juan A. Department of Surgery, Womack Army Medical Center, 2817 Reilly Road, Stop A, Fort Bragg, NC 28310. TI - Poland's breast reconstruction with decellularized human dermal allograft. SO - Military Medicine. 179(2):e249-52, 2014 Feb AS - Mil Med. 179(2):e249-52, 2014 Feb NJ - Military medicine VO - 179 IP - 2 PG - e249-52 PI - Journal available in: Print PI - Citation processed from: Internet JC - 2984771r, n1a IO - Mil Med SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Breast Implants MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - *Poland Syndrome/su [Surgery] MH - Skin Transplantation MH - Tissue Expansion MH - Transplantation, Homologous AB - The eponym of Poland's syndrome is given to a condition described by Sir Alfred Poland in 1941. The condition is characterized by a myriad of anomalies of the chest wall with multiple theories of its etiology. Usually, the patient that presents to the reconstructive breast surgeon is a female with some degree of abnormal development of her affected ipsilateral breast. Numerous options of breast reconstruction have been described in the literature for patients with Poland's breast anomalies. These include the use of autologous tissue, prosthetic material, or a combination of both. The use of dermal allograft for breast reconstruction in breast cancer has become extremely helpful and prevalent. Currently, the use of dermal allograft with the aid of the pectoralis major muscle is one of the most common techniques for breast reconstruction. However, with the absence of the pectoralis major muscle as is in the case of Poland's syndrome the utility of this technique is unknown. In this article the author describes the case of a patient with severe breast hypoplasia secondary to Poland's syndrome and the successful use of decellularized human dermal allograft only and a tissue expander, followed by postoperative adjustable mammary prosthesis. Reprint & Copyright © 2014 Association of Military Surgeons of the U.S. ES - 1930-613X IL - 0026-4075 DO - https://dx.doi.org/10.7205/MILMED-D-13-00276 PT - Case Reports PT - Journal Article ID - 10.7205/MILMED-D-13-00276 [doi] PP - ppublish LG - English DP - 2014 Feb EZ - 2014/02/05 06:00 DA - 2015/04/08 06:00 DT - 2014/02/05 06:00 YR - 2014 ED - 20150407 RD - 20171206 UP - 20171207 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medc&AN=24491626 <187. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25455288 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Reitsamer R AU - Peintinger F FA - Reitsamer, Roland FA - Peintinger, Florentia IN - Reitsamer, Roland. University Hospital Salzburg, Breast Center Salzburg, Paracelsus Medical University Salzburg, Salzburg, Austria. Electronic address: r.reitsamer@salk.at. IN - Peintinger, Florentia. University Hospital Salzburg, Breast Center Salzburg, Paracelsus Medical University Salzburg, Salzburg, Austria; Institute of Pathology Graz, Medical University Graz, Graz, Austria. TI - Prepectoral implant placement and complete coverage with porcine acellular dermal matrix: a new technique for direct-to-implant breast reconstruction after nipple-sparing mastectomy. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 68(2):162-7, 2015 Feb AS - J Plast Reconstr Aesthet Surg. 68(2):162-7, 2015 Feb NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 68 IP - 2 PG - 162-7 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Animals MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Breast Neoplasms/pc [Prevention & Control] MH - Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - *Nipples MH - *Organ Sparing Treatments/mt [Methods] MH - Patient Satisfaction MH - Pectoralis Muscles MH - Suture Techniques KW - Acellular dermal matrix; Direct-to-implant Breast reconstruction; Implant-based breast reconstruction; Nipple-sparing mastectomy AB - BACKGROUND: Nipple-sparing mastectomy (NSM) and implant-based breast reconstruction are increasingly replacing conventional mastectomy for risk-reducing purposes in high-risk patients as well as for therapeutic purposes in breast cancer patients. For implant-based breast reconstruction, generally, subpectoral implant placement with partial detachment of the pectoralis major muscle (PMM) is recommended. The advantage of a potentially better cosmetic result has to be balanced with the disadvantages, such as partial injury of the PMM with subsequent muscular deficit, breast animation, and postoperative pain. We hypothesize that prepectoral implant placement and complete coverage with a porcine acellular dermal matrix (ADM) may provide an alternative to subpectoral implant placement with an excellent cosmetic result, avoiding the disadvantages of subpectoral implant placement. AB - METHODS: In a total of 22 breasts in 13 patients (nine bilateral and four unilateral), NSM and immediate direct-to-implant breast reconstruction were performed with prepectoral implant placement. The implant was completely covered by a porcine ADM, which was sutured to the fascia of the PMM and the inframammary fold to keep the implant in place. AB - RESULTS: The cosmetic results were excellent and patients were fully satisfied at a median follow-up of 6 months. Breast animation and implant dislocation could not be observed. Implant rims were not visible, and capsular contractures grade III and IV could not be observed. The complications comprised minimal nipple necrosis in two patients and hemorrhage with evacuation in one patient. AB - CONCLUSION: Prepectoral implant placement and complete coverage with porcine ADM represents a novel approach and a feasible alternative to subpectoral implant placement after NSM and implant-based breast reconstruction for patients who prefer their PMM to be left intact. Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(14)00605-6 DO - https://dx.doi.org/10.1016/j.bjps.2014.10.012 PT - Journal Article ID - S1748-6815(14)00605-6 [pii] ID - 10.1016/j.bjps.2014.10.012 [doi] PP - ppublish PH - 2014/04/19 [received] PH - 2014/06/30 [revised] PH - 2014/10/05 [accepted] LG - English EP - 20141016 DP - 2015 Feb EZ - 2014/12/03 06:00 DA - 2015/03/27 06:00 DT - 2014/12/03 06:00 YR - 2015 ED - 20150326 RD - 20150127 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25455288 <188. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25798391 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Winocour S AU - Martinez-Jorge J AU - Habermann E AU - Thomsen K AU - Lemaine V FA - Winocour, Sebastian FA - Martinez-Jorge, Jorys FA - Habermann, Elizabeth FA - Thomsen, Kristine FA - Lemaine, Valerie IN - Winocour, Sebastian. Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA. IN - Martinez-Jorge, Jorys. Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA. IN - Habermann, Elizabeth. Department of Health Sciences Research, Rochester, NM, USA. IN - Thomsen, Kristine. Department of Health Sciences Research, Rochester, NM, USA. IN - Lemaine, Valerie. Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA. TI - Early Surgical Site Infection Following Tissue Expander Breast Reconstruction with or without Acellular Dermal Matrix: National Benchmarking Using National Surgical Quality Improvement Program. SO - Archives of Plastic Surgery. 42(2):194-200, 2015 Mar AS - Arch. plast. surg.. 42(2):194-200, 2015 Mar NJ - Archives of plastic surgery VO - 42 IP - 2 PG - 194-200 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366701 CP - Korea (South) KW - Acellular dermis; Benchmarking; Breast implantation; Surgical wound infection AB - BACKGROUND: Surgical site infections (SSIs) result in significant patient morbidity following immediate tissue expander breast reconstruction (ITEBR). This study determined a single institution's 30-day SSI rate and benchmarked it against that among national institutions participating in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). AB - METHODS: Women who underwent ITEBR with/without acellular dermal matrix (ADM) were identified using the ACS-NSQIP database between 2005 and 2011. Patient characteristics associated with the 30-day SSI rate were determined, and differences in rates between our institution and the national database were assessed. AB - RESULTS: 12,163 patients underwent ITEBR, including 263 at our institution. SSIs occurred in 416 (3.4%) patients nationwide excluding our institution, with lower rates observed at our institution (1.9%). Nationwide, SSIs were significantly more common in ITEBR patients with ADM (4.5%) compared to non-ADM patients (3.2%, P=0.005), and this trend was observed at our institution (2.1% vs. 1.6%, P=1.00). A multivariable analysis of all institutions identified age >=50 years (odds ratio [OR], 1.4; confidence interval [CI], 1.1-1.7), body mass index >=30 kg/m(2) vs. <25 kg/m(2) (OR, 3.4; CI, 2.6-4.5), and operative time >4.25 hours (OR, 1.9; CI, 1.5-2.4) as risk factors for SSIs. Our institutional SSI rate was lower than the nationwide rate (OR, 0.4; CI, 0.2-1.1), although this difference was not statistically significant (P=0.07). AB - CONCLUSIONS: The 30-day SSI rate at our institution in patients who underwent ITEBR was lower than the nation. SSIs occurred more frequently in procedures involving ADM both nationally and at our institution. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2015.42.2.194 PT - Journal Article ID - 10.5999/aps.2015.42.2.194 [doi] ID - PMC4366701 [pmc] PP - ppublish PH - 2014/08/16 [received] PH - 2014/11/09 [revised] PH - 2014/11/18 [accepted] LG - English EP - 20150316 DP - 2015 Mar EZ - 2015/03/24 06:00 DA - 2015/03/24 06:01 DT - 2015/03/24 06:00 YR - 2015 ED - 20150323 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25798391 <189. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25238954 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Barber MD AU - Williams L AU - Anderson ED AU - Neades GT AU - Raine C AU - Young O AU - Kulkarni D AU - Young I AU - Dixon JM FA - Barber, M D FA - Williams, L FA - Anderson, E D C FA - Neades, G T FA - Raine, C FA - Young, O FA - Kulkarni, D FA - Young, I FA - Dixon, J M IN - Barber, M D. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. Electronic address: matthew.barber@luht.scot.nhs.uk. IN - Williams, L. Centre for Population Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom. IN - Anderson, E D C. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. IN - Neades, G T. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. IN - Raine, C. Department of Plastic Surgery, St John's Hospital, Livingston EH54 6PP, United Kingdom. IN - Young, O. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. IN - Kulkarni, D. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. IN - Young, I. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. IN - Dixon, J M. Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. TI - Outcome of the use of acellular-dermal matrix to assist implant-based breast reconstruction in a single centre. SO - European Journal of Surgical Oncology. 41(1):100-5, 2015 Jan AS - Eur J Surg Oncol. 41(1):100-5, 2015 Jan NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 41 IP - 1 PG - 100-5 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - *Carcinoma/su [Surgery] MH - *Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - Chemotherapy, Adjuvant MH - Collagen/tu [Therapeutic Use] MH - Device Removal/sn [Statistics & Numerical Data] MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Prosthesis Failure MH - Radiotherapy, Adjuvant MH - Retrospective Studies MH - Smoking/ep [Epidemiology] MH - Time-to-Treatment MH - Treatment Outcome MH - Young Adult KW - Acellular dermal matrix; Breast; Breast reconstruction; Mastectomy; Surgical complications AB - INTRODUCTION: The use of acellular dermal matrix (ADM) has transformed the technique of implant-based breast reconstruction. It offers the option of a one-stage procedure and is felt to have benefits in cosmetic outcome but the medium and long-term outcomes are unknown. AB - METHODS: All cases where ADM was used in a breast reconstructive procedure in the Edinburgh Breast Unit from its initial use on 7/7/2008 to 31/7/2012 were reviewed retrospectively. Follow up was completed to 30/11/2012. AB - RESULTS: 147 patients received 232 sheets of ADM (156 Strattice, 73 Permacol and 3 Alloderm). Mean follow up was 687 days. In 40 cases unplanned implant explantation occurred (17.2% or 27.2% of patients). 7 of 27 (25.9%) patients requiring adjuvant therapy had this delayed due to problems with the reconstruction. 30 of 80 patients (37.5%) undergoing unilateral surgery have undergone contralateral surgery. Implant loss varied significantly with smoking (34.6% loss rate in smokers vs 13.2% in non-smokers, p = 0.001), with radiotherapy (28.1% loss rate vs 13.8% with no radiotherapy, p = 0.001) and with incision type. There was no statistically significant variation by operating surgeon, type of ADM used, chemotherapy use, patient weight, breast weight or nipple preservation. Patients underwent a mean of 1.54 further operations (range 0-7). AB - CONCLUSIONS: While offering potential cosmetic and financial benefits, the use of ADM with implant-based reconstructions has a significant rate of implant loss, further surgery and potential delay in adjuvant therapy. These must be considered when planning treatment and consenting patients. Copyright © 2014 Elsevier Ltd. All rights reserved. RN - 0 (Alloderm) RN - 0 (Permacol) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(14)01057-9 DO - https://dx.doi.org/10.1016/j.ejso.2014.08.475 PT - Journal Article ID - S0748-7983(14)01057-9 [pii] ID - 10.1016/j.ejso.2014.08.475 [doi] PP - ppublish PH - 2014/05/11 [received] PH - 2014/08/04 [revised] PH - 2014/08/19 [accepted] LG - English EP - 20140906 DP - 2015 Jan EZ - 2014/09/23 06:00 DA - 2015/03/19 06:00 DT - 2014/09/21 06:00 YR - 2015 ED - 20150318 RD - 20150708 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25238954 <190. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24011501 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Potter S AU - Chambers A AU - Govindajulu S AU - Sahu A AU - Warr R AU - Cawthorn S FA - Potter, S FA - Chambers, A FA - Govindajulu, S FA - Sahu, A FA - Warr, R FA - Cawthorn, S IN - Potter, S. Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. IN - Chambers, A. Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom. IN - Govindajulu, S. Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom. IN - Sahu, A. Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom. IN - Warr, R. Department of Plastic Surgery, North Bristol NHS Trust, Bristol, United Kingdom. IN - Cawthorn, S. Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom. Electronic address: simon.cawthorn@nbt.nhs.uk. TI - Early complications and implant loss in implant-based breast reconstruction with and without acellular dermal matrix (Tecnoss Protexa): a comparative study. SO - European Journal of Surgical Oncology. 41(1):113-9, 2015 Jan AS - Eur J Surg Oncol. 41(1):113-9, 2015 Jan NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 41 IP - 1 PG - 113-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Breast Neoplasms/pc [Prevention & Control] MH - *Breast Neoplasms/su [Surgery] MH - *Device Removal/sn [Statistics & Numerical Data] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - *Postoperative Complications MH - *Prophylactic Surgical Procedures/mt [Methods] MH - Prosthesis Failure MH - Retrospective Studies MH - Treatment Outcome KW - ADM; Breast reconstruction; Early complications; Implant loss; Retrospective; Tecnoss Protexa AB - INTRODUCTION: Acellular dermal matrix (ADM) may improve outcomes in implant-based breast reconstruction, but recent evidence suggests complication rates may be higher when ADM is used. We retrospectively compared early complications and implant loss in implant-based breast reconstruction (BR) with and without ADM to evaluate the safety of the procedure in our centre. AB - METHODS: Case-notes of consecutive women undergoing implant-based BR from May 2011 to November 2012 were retrospectively reviewed. Data were extracted using a standardised pro-forma and the rate of early complications, major complications and implant loss compared between procedure groups. AB - RESULTS: Forty-six implant-based reconstructions were performed for malignancy (n = 31, 67.4%) or prophylaxis (n = 15, 32.6%) in 31 women over the 18-month study period. ADM (Tecnoss Protexa(), Tecnoss S.r.l.) was used in 31 (67.4%) cases. There were no differences in patient age, BMI, co-morbidities, smoking or chemotherapy between groups, but patients receiving ADM were more likely to have received radiotherapy prior to their reconstruction (n = 6, 30% vs. n = 0, 0%, p = 0.043). The overall rate of early complications was 26.1% (n = 12) but there was no significant difference between procedure groups (standard-n = 4, 27.7% vs. ADM-n = 8, 25.8%; p = 0.950). There were 2 (4.3%) major complications none of which were associated with ADM use (standard-n = 2, 13.3% vs. ADM-n = 0, 0.0%; p = 0.038). There were 6 (13.0%) implant losses of which 4 were in the ADM group (standard-n = 2, 13.3% vs. ADM-n = 4, 12.9%; p = 0.968). All of these were associated with pre-reconstruction radiotherapy. AB - CONCLUSIONS: ADM-assisted implant-based reconstruction with Tecnoss Protexa() is safe and may improve outcomes for women by facilitating a single-stage procedure. Robust prospective evaluation is now needed to definitively evaluate the role of ADM in implant-based BR. Copyright © 2013 Elsevier Ltd. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(13)00755-5 DO - https://dx.doi.org/10.1016/j.ejso.2013.08.016 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S0748-7983(13)00755-5 [pii] ID - 10.1016/j.ejso.2013.08.016 [doi] PP - ppublish PH - 2013/05/28 [received] PH - 2013/08/08 [revised] PH - 2013/08/13 [accepted] LG - English EP - 20130822 DP - 2015 Jan EZ - 2013/09/10 06:00 DA - 2015/03/19 06:00 DT - 2013/09/10 06:00 YR - 2015 ED - 20150318 RD - 20150116 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24011501 <191. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25347629 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Loma Linda, Calif. From the Department of Plastic Surgery, Loma Linda University Medical Center. TI - Acellular dermal matrix for reoperative breast augmentation. [Review] SO - Plastic & Reconstructive Surgery. 134(5):932-8, 2014 Nov AS - Plast Reconstr Surg. 134(5):932-8, 2014 Nov NJ - Plastic and reconstructive surgery VO - 134 IP - 5 PG - 932-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ut [Utilization] MH - Adult MH - *Breast Implants/ae [Adverse Effects] MH - Esthetics MH - Evidence-Based Medicine MH - Female MH - Follow-Up Studies MH - Humans MH - Implant Capsular Contracture/pp [Physiopathology] MH - *Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Middle Aged MH - Prosthesis Failure MH - Reoperation/mt [Methods] MH - Risk Assessment MH - Treatment Outcome MH - Wound Healing/ph [Physiology] MH - Young Adult AB - Revisionary breast surgery in previously augmented patients is complex, with many variables that have to be considered. Obtaining durable repairs is challenging because these patients often present with thinned breast tissue, inadequate local tissue, and/or scarred breast envelope from multiple procedures. Capsular contracture, ptosis, tissue atrophy, and wrinkling/rippling are some of the most frequent reasons for reoperation. Conventional repair techniques generally involve a combination of capsule modification (capsular flaps), site change, mastopexy, and implant exchange. Recently, acellular dermal matrices have been introduced into revision surgery to reinforce soft tissue, reinforce the implant pocket, and potentially mitigate capsular contracture. Clinical outcomes of acellular dermal matrix-assisted revision surgery are reviewed from the published literature to evaluate the efficacy and safety of acellular dermal matrices for this indication. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000777 PT - Journal Article PT - Review ID - 10.1097/PRS.0000000000000777 [doi] ID - 00006534-201411000-00014 [pii] PP - ppublish LG - English DP - 2014 Nov EZ - 2014/10/28 06:00 DA - 2015/03/17 06:00 DT - 2014/10/28 06:00 YR - 2014 ED - 20150316 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25347629 <192. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25347626 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Martin JB AU - Moore R AU - Paydar KZ AU - Wirth GA FA - Martin, Jenna B FA - Moore, Ryan FA - Paydar, Keyianoosh Z FA - Wirth, Garrett A IN - Martin, Jenna B. Orange, Calif. From the Department of Plastic Surgery, University of California, Irvine. TI - Use of fenestrations in acellular dermal allograft in two-stage tissue expander/implant breast reconstruction. SO - Plastic & Reconstructive Surgery. 134(5):901-4, 2014 Nov AS - Plast Reconstr Surg. 134(5):901-4, 2014 Nov NJ - Plastic and reconstructive surgery VO - 134 IP - 5 PG - 901-4 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ut [Utilization] MH - Allografts MH - *Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - California MH - Cohort Studies MH - Esthetics MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Hospitals, University MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/su [Surgery] MH - Retrospective Studies MH - Risk Assessment MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome AB - UNLABELLED: The authors present a new technique of alteration of the acellular dermal matrix through strategically placed fenestrations, improving the reconstructive experience and overall cosmetic outcome. The authors present a retrospective chart review following two surgeons' experience at the University of California, Irvine, Department of Plastic Surgery using surgeon-designed fenestrated acellular dermal matrices in two-stage tissue expander breast reconstruction. The authors found that this leads to improved intraoperative fill volume, decreased number of postoperative expansions, increased expansion rate with subjectively less pain, decreased time to full expansion, and subjectively improved cosmetic outcome. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000598 PT - Evaluation Studies PT - Journal Article ID - 10.1097/PRS.0000000000000598 [doi] ID - 00006534-201411000-00008 [pii] PP - ppublish LG - English DP - 2014 Nov EZ - 2014/10/28 06:00 DA - 2015/03/17 06:00 DT - 2014/10/28 06:00 YR - 2014 ED - 20150316 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25347626 <193. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25347625 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Haynes DF AU - Kreithen JC FA - Haynes, Daniel F FA - Kreithen, Joshua C IN - Haynes, Daniel F. Johnson City, Tenn.; and Bradenton, Fla. From the Division of Plastic Surgery, East Tennessee State University; and Lakewood Ranch Plastic Surgery. TI - Vicryl mesh in expander/implant breast reconstruction: long-term follow-up in 38 patients. SO - Plastic & Reconstructive Surgery. 134(5):892-9, 2014 Nov AS - Plast Reconstr Surg. 134(5):892-9, 2014 Nov NJ - Plastic and reconstructive surgery VO - 134 IP - 5 PG - 892-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Breast Implants MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Databases, Factual MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - *Polyglactin 910/pd [Pharmacology] MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/su [Surgery] MH - Prosthesis Failure MH - Radiotherapy, Adjuvant MH - Retrospective Studies MH - Risk Assessment MH - Surgical Mesh MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome MH - United States AB - BACKGROUND: Acellular dermal matrix has proven to be a useful adjunct in tissue expander or direct-to-implant breast reconstruction. Although versatile, acellular dermal matrix adds considerable cost. Vicryl (polyglactin) mesh has an established track record in many fields of surgery, and is considerably less costly than acellular dermal matrix. This study examines the use and long-term follow-up of Vicryl mesh in breast reconstruction. AB - METHODS: Vicryl mesh was used in 46 breast reconstructions (38 patients; 35 immediate and three delayed). The mesh was used along the inframammary fold to maintain position of the inferior pectoral edge, and/or along the lateral border to maintain expander position and prevent lateral migration. Eight breasts received adjuvant radiation therapy. AB - RESULTS: Mean follow-up at the time of review was 43 months. In the nonirradiated group (38 breasts), there was one postoperative infection (2.6 percent), which required expander removal. In the irradiated group, there were three complications requiring expander removal (37.5 percent): two infections and one device exposure after irradiation. Significant malposition was not observed in any breast where Vicryl mesh was used, and no visible mesh remained at the time of implant placement. The incidence of symptomatic capsular contracture in nonirradiated breasts was 3.2 percent. At latest follow-up, nonirradiated breasts had an average Baker capsule grade of 1.1, compared with 1.5 in the irradiated group. AB - CONCLUSIONS: Vicryl mesh is an effective alternative to acellular dermal matrix in nonirradiated breast reconstruction and is available at approximately one-twentieth the cost. Acellular dermal matrix or full muscle coverage may be preferable in irradiated reconstructions. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 34346-01-5 (Polyglactin 910) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000610 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0000000000000610 [doi] ID - 00006534-201411000-00006 [pii] PP - ppublish LG - English DP - 2014 Nov EZ - 2014/10/28 06:00 DA - 2015/03/17 06:00 DT - 2014/10/28 06:00 YR - 2014 ED - 20150316 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25347625 <194. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25539350 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Myckatyn TM AU - Cavallo JA AU - Sharma K AU - Gangopadhyay N AU - Dudas JR AU - Roma AA AU - Baalman S AU - Tenenbaum MM AU - Matthews BD AU - Deeken CR FA - Myckatyn, Terence M FA - Cavallo, Jaime A FA - Sharma, Ketan FA - Gangopadhyay, Noopur FA - Dudas, Jason R FA - Roma, Andres A FA - Baalman, Sara FA - Tenenbaum, Marissa M FA - Matthews, Brent D FA - Deeken, Corey R IN - Myckatyn, Terence M. St. Louis, Mo.; and Cleveland, Ohio From the Division of Plastic and Reconstructive Surgery, the Department of Surgery, Section of Minimally Invasive Surgery, Washington University School of Medicine; and the Department of Anatomic Pathology, Cleveland Clinic. TI - The impact of chemotherapy and radiation therapy on the remodeling of acellular dermal matrices in staged, prosthetic breast reconstruction. SO - Plastic & Reconstructive Surgery. 135(1):43e-57e, 2015 Jan AS - Plast Reconstr Surg. 135(1):43e-57e, 2015 Jan NJ - Plastic and reconstructive surgery VO - 135 IP - 1 PG - 43e-57e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515029 OI - Source: NLM. NIHMS707929 SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/de [Drug Effects] MH - *Acellular Dermis/re [Radiation Effects] MH - Adult MH - *Breast Implantation MH - *Breast Neoplasms/th [Therapy] MH - Female MH - Humans MH - Middle Aged MH - Retrospective Studies AB - BACKGROUND: An acellular dermal matrix will typically incorporate, in time, with the overlying mastectomy skin flap. This remodeling process may be adversely impacted in patients who require chemotherapy and radiation, which influence neovascularization and cellular proliferation. AB - METHODS: Multiple biopsy specimens were procured from 86 women (n = 94 breasts) undergoing exchange of a tissue expander for a breast implant. These were divided by biopsy location: submuscular capsule (control) as well as superiorly, centrally, and inferiorly along the paramedian acellular dermis. Specimens were assessed for cellular infiltration, cell type, fibrous encapsulation, scaffold degradation, extracellular matrix deposition, neovascularization, mean composite remodeling score, and type I and III collagen. Patients were compared based on five oncologic treatment groups: no adjuvant therapy (untreated), neoadjuvant chemotherapy with or without radiation, and chemotherapy with or without radiation. AB - RESULTS: Biopsy specimens were procured 45 to 1805 days after implantation and demonstrated a significant reduction in type I collagen over time. Chemotherapy adversely impacted fibrous encapsulation (p = 0.03). Chemotherapy with or without radiation adversely impacted type I collagen (p = 0.02), cellular infiltration (p < 0.01), extracellular matrix deposition (p < 0.04), and neovascularization (p < 0.01). Radiation exacerbated the adverse impact of chemotherapy for several remodeling parameters. Neoadjuvant chemotherapy also caused a reduction in type I (p = 0.01) and III collagen (p = 0.05), extracellular matrix deposition (p = 0.03), and scaffold degradation (p = 0.02). AB - CONCLUSION: Chemotherapy and radiation therapy limit acellular dermal matrix remodeling. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000807 PT - Journal Article PT - Research Support, N.I.H., Extramural ID - 10.1097/PRS.0000000000000807 [doi] ID - 00006534-201501000-00011 [pii] ID - PMC4515029 [pmc] ID - NIHMS707929 [mid] PP - ppublish GI - No: P30CA091842 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: UL1TR000448 Organization: (TR) *NCATS NIH HHS* Country: United States GI - No: P30 CA091842 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: UL1 TR000448 Organization: (TR) *NCATS NIH HHS* Country: United States GI - No: KM1CA156708 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: KM1 CA156708 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2015 Jan EZ - 2014/12/30 06:00 DA - 2015/03/10 06:00 DT - 2014/12/25 06:00 YR - 2015 ED - 20150309 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25539350 <195. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25539349 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mendenhall SD AU - Anderson LA AU - Ying J AU - Boucher KM AU - Liu T AU - Neumayer LA AU - Agarwal JP FA - Mendenhall, Shaun D FA - Anderson, Layla A FA - Ying, Jian FA - Boucher, Kenneth M FA - Liu, Ting FA - Neumayer, Leigh A FA - Agarwal, Jayant P IN - Mendenhall, Shaun D. Salt Lake City, Utah; and Springfield, Ill. From the Division of Plastic and Reconstructive Surgery, the Department of Surgery, the Division of Epidemiology, Department of Internal Medicine, and the Department of Pathology, University of Utah School of Medicine; and the Institute for Plastic Surgery, Southern Illinois University School of Medicine. TI - The BREASTrial: stage I. Outcomes from the time of tissue expander and acellular dermal matrix placement to definitive reconstruction. SO - Plastic & Reconstructive Surgery. 135(1):29e-42e, 2015 Jan AS - Plast Reconstr Surg. 135(1):29e-42e, 2015 Jan NJ - Plastic and reconstructive surgery VO - 135 IP - 1 PG - 29e-42e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Skin, Artificial MH - *Tissue Expansion MH - Treatment Outcome AB - BACKGROUND: Use of acellular dermal matrix in tissue expander breast reconstruction has become a popular adjunct to the total submuscular technique. The question remains as to which matrix, if any, is ideal for breast reconstruction. AB - METHODS: A randomized trial was conducted to analyze outcomes of immediate staged tissue expander breast reconstruction using either AlloDerm or DermaMatrix. The impact of obesity, radiation, and chemotherapy on complications and biointegration of matrix was investigated. The trial was divided into three stages, with stage I results reported here. AB - RESULTS: One hundred twenty-eight patients (199 breasts) were randomized equally over 2.5 years. Most patients were white, healthy nonsmokers. The overall complication rate was 36.2 percent; half of the complications were minor. The AlloDerm and DermaMatrix groups had similar rates of complications (33.6 percent versus 38.8 percent; p = 0.52), consisting mostly of skin necrosis (17.8 percent versus 21.4 percent; p = 0.66) and infections (13.9 percent versus 16.3 percent; p = 0.29), both of which led to tissue expander losses (5 percent versus 11.2 percent; p = 0.11). The AlloDerm group required less time for completion of expansion (42 days versus 70 days; p < 0.001). Obesity was associated with poor matrix biointegration and a longer drain time, both of which were associated with higher complication rates. AB - CONCLUSION: The Breast Reconstruction Evaluation Using Acellular Dermal Matrix as a Sling Trial is the largest randomized trial to date in matrix breast reconstruction and emphasizes the importance of careful patient and allograft selection to minimize complications. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000758 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0000000000000758 [doi] ID - 00006534-201501000-00009 [pii] PP - ppublish LG - English DP - 2015 Jan EZ - 2014/12/30 06:00 DA - 2015/03/10 06:00 DT - 2014/12/25 06:00 YR - 2015 ED - 20150309 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25539349 <196. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25539330 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Agarwal JP AU - Mendenhall SD AU - Anderson LA AU - Ying J AU - Boucher KM AU - Liu T AU - Neumayer LA FA - Agarwal, Jayant P FA - Mendenhall, Shaun D FA - Anderson, Layla A FA - Ying, Jian FA - Boucher, Kenneth M FA - Liu, Ting FA - Neumayer, Leigh A IN - Agarwal, Jayant P. Salt Lake City, Utah; and Springfield, Ill. From the Division of Plastic and Reconstructive Surgery, the Department of Surgery, the Division of Epidemiology, Department of Internal Medicine, and the Department of Pathology, University of Utah School of Medicine; and the Institute for Plastic Surgery, Southern Illinois University School of Medicine. TI - The breast reconstruction evaluation of acellular dermal matrix as a sling trial (BREASTrial): design and methods of a prospective randomized trial. SO - Plastic & Reconstructive Surgery. 135(1):20e-8e, 2015 Jan AS - Plast Reconstr Surg. 135(1):20e-8e, 2015 Jan NJ - Plastic and reconstructive surgery VO - 135 IP - 1 PG - 20e-8e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Prospective Studies MH - Randomized Controlled Trials as Topic/mt [Methods] MH - Research Design MH - Single-Blind Method MH - Young Adult AB - BACKGROUND: Recent literature has focused on the advantages and disadvantages of using acellular dermal matrix in breast reconstruction. Many of the reported data are from low level-of-evidence studies, leaving many questions incompletely answered. The present randomized trial provides high-level data on the incidence and severity of complications in acellular dermal matrix breast reconstruction between two commonly used types of acellular dermal matrix. AB - METHODS: A prospective randomized trial was conducted to compare outcomes of immediate staged tissue expander breast reconstruction using either AlloDerm or DermaMatrix. The impact of body mass index, smoking, diabetes, mastectomy type, radiation therapy, and chemotherapy on outcomes was analyzed. Acellular dermal matrix biointegration was analyzed clinically and histologically. Patient satisfaction was assessed by means of preoperative and postoperative surveys. Logistic regression models were used to identify predictors of complications. AB - RESULTS: This article reports on the study design, surgical technique, patient characteristics, and preoperative survey results, with outcomes data in a separate report. After 2.5 years, we successfully enrolled and randomized 128 patients (199 breasts). The majority of patients were healthy nonsmokers, with 41 percent of patients receiving radiation therapy and 49 percent receiving chemotherapy. Half of the mastectomies were prophylactic, with nipple-sparing mastectomy common in both cancer and prophylactic cases. Preoperative survey results indicate that patients were satisfied with their premastectomy breast reconstruction education. AB - CONCLUSION: Results from the Breast Reconstruction Evaluation Using Acellular Dermal Matrix as a Sling Trial will assist plastic surgeons in making evidence-based decisions regarding acellular dermal matrix-assisted tissue expander breast reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000809 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0000000000000809 [doi] ID - 00006534-201501000-00008 [pii] PP - ppublish LG - English DP - 2015 Jan EZ - 2014/12/30 06:00 DA - 2015/03/10 06:00 DT - 2014/12/25 06:00 YR - 2015 ED - 20150309 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25539330 <197. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24304366 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mestak O AU - Matouskova E AU - Spurkova Z AU - Benkova K AU - Vesely P AU - Mestak J AU - Molitor M AU - Pombinho A AU - Sukop A FA - Mestak, Ondrej FA - Matouskova, Eva FA - Spurkova, Zuzana FA - Benkova, Kamila FA - Vesely, Pavel FA - Mestak, Jan FA - Molitor, Martin FA - Pombinho, Antonio FA - Sukop, Andrej IN - Mestak, Ondrej. Department of Plastic Surgery, 1st Faculty of Medicine, Charles University in Prague, Bulovka Hospital, Prague, Czech Republic. TI - Mesenchymal stem cells seeded on cross-linked and noncross-linked acellular porcine dermal scaffolds for long-term full-thickness hernia repair in a small animal model. SO - Artificial Organs. 38(7):572-9, 2014 Jul AS - Artif Organs. 38(7):572-9, 2014 Jul NJ - Artificial organs VO - 38 IP - 7 PG - 572-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8zk, 7802778 IO - Artif Organs SB - Index Medicus CP - United States MH - Adipose Tissue/cy [Cytology] MH - Animals MH - Cell Differentiation MH - Cells, Cultured MH - Cross-Linking Reagents/ch [Chemistry] MH - *Dermis/cy [Cytology] MH - *Extracellular Matrix/ch [Chemistry] MH - Female MH - *Hernia/th [Therapy] MH - *Mesenchymal Stromal Cells/cy [Cytology] MH - Rats, Wistar MH - Swine MH - Tissue Engineering MH - *Tissue Scaffolds/ch [Chemistry] KW - Acellular matrix; Adipose-derived stem cells; Animal model; Biocompatibility; Cross-linking; Extracellular matrix; Hernia; Mesenchymal stem cells; Scaffold AB - Biological meshes are biomaterials consisting of extracellular matrix that are used in surgery particularly for hernia treatment, thoracic wall reconstruction, or silicone implant-based breast reconstruction. We hypothesized that combination of extracellular matrices with autologous mesenchymal stem cells used for hernia repair would result in increased vascularization and increased strength of incorporation. We cultured autologous adipose-derived stem cells harvested from the inguinal region of Wistar rats on cross-linked and noncross-linked porcine extracellular matrices. In 24 Wistar rats, a standardized 2x4cm fascial defect was created and repaired with either cross-linked or noncross-linked grafts enriched with stem cells. Non-MSC-enriched grafts were used as controls. The rats were sacrificed at 3 months of age. The specimens were examined for the strength of incorporation, vascularization, cell invasion, foreign body reaction, and capsule formation. Both materials showed cellular ingrowth and neovascularization. Comparison of both tested groups with the controls showed no significant differences in the capsule thickness, foreign body reaction, cellularization, or vascularization. The strength of incorporation of the stem cell-enriched cross-linked extracellular matrix specimens was higher than in acellular specimens, but this result was statistically nonsignificant. In the noncross-linked extracellular matrix, the strength of incorporation was significantly higher in the stem cell group than in the acellular group. Seeding of biological meshes with stem cells does not significantly contribute to their increased vascularization. In cross-linked materials, it does not ensure increased strength of incorporation, in contrast to noncross-linked materials. Owing to the fact that isolation and seeding of stem cells is a very complex procedure, we do not see sufficient benefits for its use in the clinical setting. Copyright © 2013 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. RN - 0 (Cross-Linking Reagents) ES - 1525-1594 IL - 0160-564X DO - https://dx.doi.org/10.1111/aor.12224 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1111/aor.12224 [doi] PP - ppublish LG - English EP - 20131204 DP - 2014 Jul EZ - 2013/12/07 06:00 DA - 2015/03/10 06:00 DT - 2013/12/06 06:00 YR - 2014 ED - 20150309 RD - 20140721 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24304366 <198. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24882349 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ballard TN AU - Momoh AO FA - Ballard, Tiffany Nicole S FA - Momoh, Adeyiza O IN - Ballard, Tiffany Nicole S. Section of Plastic Surgery, Department of General Surgery, University of Michigan Health System, 1500 East Medical Center Drive, 2130 Taubman Center, SPC 5340, Ann Arbor, MI 48109-5340, USA. IN - Momoh, Adeyiza O. Section of Plastic Surgery, Department of General Surgery, University of Michigan Health System, 1500 East Medical Center Drive, 2130 Taubman Center, SPC 5340, Ann Arbor, MI 48109-5340, USA. Electronic address: amomoh@umich.edu. TI - Advances in breast reconstruction of mastectomy and lumpectomy defects. [Review] SO - Surgical Oncology Clinics of North America. 23(3):525-48, 2014 Jul AS - Surg Oncol Clin N Am. 23(3):525-48, 2014 Jul NJ - Surgical oncology clinics of North America VO - 23 IP - 3 PG - 525-48 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9211789, CAF IO - Surg. Oncol. Clin. N. Am. SB - Index Medicus CP - United States MH - Acellular Dermis MH - Algorithms MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Obesity MH - Surgical Flaps MH - Tissue Expansion MH - *Wounds and Injuries/su [Surgery] KW - Acellular dermal matrix; Autologous fat grafting; Autologous flap; Breast reconstruction; Implant; Radiation; Tissue expander; Tissue transfer AB - Breast reconstruction continues to evolve along with advances in the detection and management of breast cancer. With more patients diagnosed with breast cancer earlier in life and increased identification of genetic mutations predisposing patients to breast cancer, patients' desires and expectations regarding reconstruction have become more sophisticated. Restoration of the breast to a form as close as possible to its presurgical state continues to be a primary goal. The past decade has seen many advances in implant and autologous tissue-based reconstruction. The future of reconstruction for breast cancer patients is promising with continued research in ways to improve the care provided. Copyright © 2014 Elsevier Inc. All rights reserved. ES - 1558-5042 IL - 1055-3207 DI - S1055-3207(14)00029-5 DO - https://dx.doi.org/10.1016/j.soc.2014.03.012 PT - Journal Article PT - Review ID - S1055-3207(14)00029-5 [pii] ID - 10.1016/j.soc.2014.03.012 [doi] PP - ppublish LG - English EP - 20140426 DP - 2014 Jul EZ - 2014/06/03 06:00 DA - 2015/02/13 06:00 DT - 2014/06/03 06:00 YR - 2014 ED - 20150212 RD - 20140602 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24882349 <199. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25610697 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Busse B AU - Orbay H AU - Sahar DE FA - Busse, Brittany FA - Orbay, Hakan FA - Sahar, David E IN - Busse, Brittany. Department of Surgery, UC Davis School of Medicine, Sacramento, CA 95817, USA. IN - Orbay, Hakan. Division of Plastic Surgery, UC Davis School of Medicine, Sacramento, CA 95817, USA. IN - Sahar, David E. Division of Plastic Surgery, UC Davis School of Medicine, Sacramento, CA 95817, USA ; Division of Plastic Surgery, University of California Davis Medical Center, Cypress Building 2221 Stockton Boulevard, Suite 2125, Sacramento, CA 95817, USA. TI - Sterile acellular dermal collagen as a treatment for rippling deformity of breast. SO - Case Reports in Surgery. 2014:876254, 2014 AS - Case Rep Surg. 2014:876254, 2014 NJ - Case reports in surgery VO - 2014 PG - 876254 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101580191 IO - Case Rep Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290364 CP - United States AB - Prosthetic implants are frequently used for breast augmentation and breast reconstruction following mastectomy. Unfortunately, long-term aesthetic results of prosthetic breast restoration may be hindered by complications such as rippling, capsular contracture, and implant malposition. The advent of use of acellular dermal matrices has greatly improved the outcomes of prosthetic breast reconstruction. We describe a case of rippling deformity of breast that was treated using an acellular dermal matrix product, AlloMax. The patient presented with visible rippling of bilateral prosthetic breast implants as well as significant asymmetry of the breasts after multiple excisional biopsies for right breast ductal carcinoma in situ. A 6 x 10cm piece of AlloMax was placed on the medial aspect of each breast between the implant and the skin flap. Follow-up was performed at 1 week, 3 months, and 1 year following the procedure. The patient recovered well from the surgery and there were no complications. At her first postoperative follow-up the patient was extremely satisfied with the result. At her 3-month and 1-year follow-up she had no recurrence of her previous deformity and no new deformity. IS - 2090-6900 DO - https://dx.doi.org/10.1155/2014/876254 PT - Journal Article ID - 10.1155/2014/876254 [doi] ID - PMC4290364 [pmc] PP - ppublish PH - 2014/06/23 [received] PH - 2014/12/11 [accepted] LG - English EP - 20141225 DP - 2014 EZ - 2015/01/23 06:00 DA - 2015/01/23 06:01 DT - 2015/01/23 06:00 YR - 2014 ED - 20150122 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25610697 <200. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25360653 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Long X AU - Bai M AU - Zeng A AU - Zhao R AU - Wang XJ FA - Long, Xiao FA - Bai, Ming FA - Zeng, Ang FA - Zhao, Ru FA - Wang, Xiao-jun IN - Long, Xiao. Department of Plastic and Aesthetic Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. IN - Bai, Ming. Department of Plastic and Aesthetic Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. IN - Zeng, Ang. Department of Plastic and Aesthetic Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. IN - Zhao, Ru. Department of Plastic and Aesthetic Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. IN - Wang, Xiao-jun. Department of Plastic and Aesthetic Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. TI - [Application of acellular allograft dermal matrix in breast implants for secondary breast deformity post polyacrylamide hydrogel removal]. [Chinese] SO - Chung-Kuo i Hsueh Ko Hsueh Yuan Hsueh Pao Acta Academiae Medicinae Sinicae. 36(5):530-3, 2014 Oct AS - Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 36(5):530-3, 2014 Oct NJ - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae VO - 36 IP - 5 PG - 530-3 PI - Journal available in: Print PI - Citation processed from: Print JC - czs, 8006230 IO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao SB - Index Medicus CP - China MH - *Acellular Dermis MH - Acrylic Resins/ae [Adverse Effects] MH - Adult MH - Allografts MH - *Breast/ab [Abnormalities] MH - *Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - Device Removal/ae [Adverse Effects] MH - Female MH - Follow-Up Studies MH - Humans MH - Middle Aged MH - Postoperative Complications/su [Surgery] MH - Retrospective Studies AB - OBJECTIVE: To evaluate the safety and efficiency of acellular dermal matrix combined with implant in correcting the secondary deformity post polyacrylamide hydrogel removal. AB - METHODS: A retrospective study enrolling 23 female patients (42 breasts) who received breast deformity correction from June 2008 to June 2012 with acellular dermal matrix and implant were performed. AB - RESULTS: One patient suffered bilateral seroma and 1 patient suffered infection in one side. None of the implants were removed. Patients were followed up for (15.0+/-11.7) months (range: 3-36 months), and the results were satisfactory. AB - CONCLUSION: Acelluar dermal matrix and implant can be safely used simultaneously in correcting the secondary breast deformity post polyacrylamide hydrogel removal. RN - 0 (Acrylic Resins) RN - 0 (polyacrylamide gels) IS - 1000-503X IL - 1000-503X DO - https://dx.doi.org/10.3881/j.issn.1000-503X.2014.05.014 PT - English Abstract PT - Journal Article ID - 10.3881/j.issn.1000-503X.2014.05.014 [doi] PP - ppublish LG - Chinese DP - 2014 Oct EZ - 2014/11/02 06:00 DA - 2015/01/16 06:00 DT - 2014/11/01 06:00 YR - 2014 ED - 20150115 RD - 20141101 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25360653 <201. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24570179 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Farias-Eisner GT AU - Small K AU - Swistel A AU - Ozerdem U AU - Talmor M FA - Farias-Eisner, Gina T FA - Small, Kevin FA - Swistel, Alexander FA - Ozerdem, Ugur FA - Talmor, Mia IN - Farias-Eisner, Gina T. Division of Plastic Surgery, Weill Cornell Medical College, 425 East 61st Street, 10th Floor, New York, NY, 10065, USA. TI - Immediate implant breast reconstruction with acellular dermal matrix for treatment of a large recurrent malignant phyllodes tumor. SO - Aesthetic Plastic Surgery. 38(2):373-8, 2014 Apr AS - Aesthetic Plast Surg. 38(2):373-8, 2014 Apr NJ - Aesthetic plastic surgery VO - 38 IP - 2 PG - 373-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Biopsy, Needle MH - *Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - Immunohistochemistry MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Neoplasm Invasiveness/pa [Pathology] MH - Neoplasm Recurrence, Local/pa [Pathology] MH - *Neoplasm Recurrence, Local/su [Surgery] MH - Neoplasm Staging MH - Phyllodes Tumor/pa [Pathology] MH - *Phyllodes Tumor/su [Surgery] MH - Rare Diseases MH - Tomography, X-Ray Computed/mt [Methods] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - UNLABELLED: Phyllodes tumors (PT) are rare fibroepithelial breast tumors representing less than 1 % of all breast malignancies. These tumors are unpredictable and fast growing with a high local recurrence rate, making this disease challenging to treat. Previous literature focused on surgical resection, and breast reconstruction following a mastectomy in patients with PT is rarely addressed. We report a case of a recurrent malignant PT treated with a nipple-sparing mastectomy followed by immediate single-stage silicone implant breast reconstruction. While PT is a rare breast malignancy that presents challenges with both surgical resection and reconstruction, we demonstrate that nipple-sparing mastectomy with immediate implant breast reconstruction with AlloMax is curative and can offer an appealing cosmetic option. AB - LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-014-0283-9 PT - Case Reports PT - Journal Article ID - 10.1007/s00266-014-0283-9 [doi] PP - ppublish PH - 2013/06/13 [received] PH - 2014/01/19 [accepted] LG - English EP - 20140226 DP - 2014 Apr EZ - 2014/02/27 06:00 DA - 2015/01/08 06:00 DT - 2014/02/27 06:00 YR - 2014 ED - 20150107 RD - 20140429 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24570179 <202. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24835873 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rinker B AU - Thornton BP FA - Rinker, Brian FA - Thornton, Brian P IN - Rinker, Brian. From the *Department of Surgery, Division of Plastic Surgery, University of Kentucky, Lexington, KY; and +The Kentucky Aesthetic Plastic Surgery Institute, Louisville, KY. TI - Skin-sparing mastectomy and immediate tissue expander breast reconstruction in patients with macromastia using the Passot breast reduction pattern. SO - Annals of Plastic Surgery. 72(6):S158-64, 2014 AS - Ann Plast Surg. 72(6):S158-64, 2014 NJ - Annals of plastic surgery VO - 72 IP - 6 PG - S158-64 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - *Breast/ab [Abnormalities] MH - Breast/su [Surgery] MH - Breast Neoplasms/su [Surgery] MH - Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - Female MH - Humans MH - *Hypertrophy/su [Surgery] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Retrospective Studies MH - Tissue Expansion MH - Tissue Expansion Devices AB - Skin-sparing mastectomy (SSM) with immediate tissue expander reconstruction poses a challenge in the patient with macromastia or excessive ptosis. Skin reduction via the Wise pattern has been described but is associated with high rates of skin necrosis. The study group consisted of 43 women with grade 2 or 3 ptosis who underwent SSM and immediate reconstruction with tissue expanders, using the Passot (horizontal) skin reduction pattern. Age ranged from 31 to 67 years (mean, 51 years). The endpoints measured were time to final expansion, mastectomy skin flap necrosis, infectious complications, and total complications. Thirty reconstructions were bilateral and 13 were unilateral (73 breasts total). Follow-up ranged from 6 to 55 months (mean, 20). Common comorbid conditions included hypertension (n = 16), obesity (n = 22), and smoking (n = 9). The mean body mass index was 30.6 (range, 19.4-58.6). Twenty-one patients underwent chemotherapy; 12 received radiation. The mean initial fill was 196 mL (range, 0-420 mL), and the mean time to final expansion was 84 days (range, 28-225 days). Five patients did not complete the reconstruction, 2 because of cancer recurrence and 3 because of infection. There were 3 cases of mastectomy flap necrosis occurring after tissue expander placement (7%). There were 7 infectious complications (16%). The use of a horizontal breast reduction pattern at the time of expander placement produces consistently good esthetic outcomes and a low rate of skin necrosis, and it should be considered as an option in patients with macromastia or ptosis undergoing SSM and immediate reconstruction. RS - Gigantomastia ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/01.sap.0000435768.51143.c9 PT - Journal Article ID - 10.1097/01.sap.0000435768.51143.c9 [doi] ID - 00000637-201406000-00042 [pii] PP - ppublish LG - English DP - 2014 EZ - 2014/05/20 06:00 DA - 2015/01/06 06:00 DT - 2014/05/20 06:00 YR - 2014 ED - 20150105 RD - 20140519 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24835873 <203. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24691348 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chapman-Jackson ED AU - Griner D AU - Brzezienski MA FA - Chapman-Jackson, Emme D FA - Griner, Devan FA - Brzezienski, Mark A IN - Chapman-Jackson, Emme D. From the Department of Plastic Surgery, University of Tennessee College of Medicine, Chattanooga, TN. TI - Circumvertical mastectomy incision: refinement in the surgical scar of implant-based breast reconstruction. SO - Annals of Plastic Surgery. 72(6):S97-102, 2014 AS - Ann Plast Surg. 72(6):S97-102, 2014 NJ - Annals of plastic surgery VO - 72 IP - 6 PG - S97-102 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implantation MH - *Breast Neoplasms/su [Surgery] MH - *Cicatrix/pc [Prevention & Control] MH - Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Skin, Artificial AB - Different surgical incisions have been proposed for skin-sparing mastectomy in an attempt to better disguise the remaining scar. These techniques are more hidden than the Stewart incision but can still leave scars in visible places and can restrict the natural shape of the upper pole. They can also add complexity and time to the mastectomy, requiring extensive retraction that could damage the salvaged skin flaps to perform an adequate mastectomy. We present a circumvertical mastectomy incision technique, which limits the mastectomy scar to the inferior pole, provides natural lateral contour, superior pole fullness, and contributes to a more youthful breast projection. Between November 2011 and November 2012, 51 women underwent circumvertical AlloDerm/tissue expansion reconstruction at our institution by a single surgeon. The reconstruction was bilateral in 30 patients and unilateral in 21 patients for a total of 81 breasts. Of the 81 reconstructed breasts, 5 patients went on to require a latissimus dorsi flap for definitive reconstruction and 3 failed breast reconstruction for a completion rate of 96%. The goal of creating breast reconstruction results comparable to those of cosmetic breast surgery is becoming a reality. Circumvertical incision is a technique that can prevent visible upper hemispheric breast scarring, limit upper pole constriction by scar placement, and preserves or restores breast projection. Following the principles of aesthetic breast surgery and repositioning the mastectomy scar, one can reconstruct a breast with a more disguised scar, which can be hidden from the patient's downward gaze. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000094 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/SAP.0000000000000094 [doi] PP - ppublish LG - English DP - 2014 EZ - 2014/04/03 06:00 DA - 2015/01/06 06:00 DT - 2014/04/03 06:00 YR - 2014 ED - 20150105 RD - 20140519 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24691348 <204. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24374400 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Showalter BM AU - Crantford JC AU - Russell GB AU - Marks MW AU - DeFranzo AJ AU - Thompson JT AU - Pestana IA AU - David LR FA - Showalter, Brian M FA - Crantford, J Clayton FA - Russell, Gregory B FA - Marks, Malcolm W FA - DeFranzo, Anthony J FA - Thompson, James T FA - Pestana, Ivo A FA - David, Lisa R IN - Showalter, Brian M. From the *Department of Plastic and Reconstructive Surgery, Wake Forest Baptist Health, Winston-Salem, NC; and +Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC. TI - The effect of reusable versus disposable draping material on infection rates in implant-based breast reconstruction: a prospective randomized trial. SO - Annals of Plastic Surgery. 72(6):S165-9, 2014 AS - Ann Plast Surg. 72(6):S165-9, 2014 NJ - Annals of plastic surgery VO - 72 IP - 6 PG - S165-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - *Breast Implantation MH - *Breast Neoplasms/su [Surgery] MH - Disposable Equipment MH - Equipment Reuse MH - Female MH - Humans MH - Middle Aged MH - Prospective Studies MH - Surgical Drapes/mi [Microbiology] MH - *Surgical Drapes MH - *Surgical Wound Infection/pc [Prevention & Control] AB - BACKGROUND: Clinical infection remains a significant problem in implant-based breast reconstruction and is a physical and emotional strain to the breast reconstruction patient. Bacterial strikethrough of draping and gown material is a likely source of infection. Strategies to reduce infection in implant-based breast reconstruction are essential to improve patient outcomes. AB - OBJECTIVE: The aim of this study is to determine if a disposable draping system is superior to reusable draping materials in the prevention of implant-based breast reconstruction infection. AB - METHODS: This single-institution, prospective, randomized, single-blinded, IRB-approved study enrolled women with breast cancer who were eligible for implant-based breast reconstruction. The primary endpoint was clinical infection by postoperative day 30. Secondary endpoints included all other complications encountered throughout the follow-up period and culture data. Demographic data recorded included patient age, body mass index, diabetes, smoking, chemotherapy, radiation, and follow-up. Procedural data recorded included procedure type, procedure length, estimated blood loss, use of acellular dermal matrix, use of muscle flap, and inpatient versus outpatient setting. AB - RESULTS: From March 2010 through January 2012, 107 women were randomized and 102 completed the study. Five patients were determined not to be candidates for reconstruction after randomization. There were 43 patients in the Reusable Group and 59 patients in the Disposable Group. There were no significant differences in patient demographic data, procedural data, or the type of procedure performed between groups. In the Reusable Group, there were 5 infections (12%) within 30 days compared to 0 (0%) infections in the Disposable Group (P = 0.012). There was no significant difference in secondary complications. There was a trend for positive wound cultures (11% vs. 3%, P = 0.10) and positive drape cultures (17% vs.4%, P = 0.08) in patients with clinical infection. There were no differences in the number of colony-forming units or positive cultures between groups. AB - CONCLUSIONS: Disposable draping material is superior to a reusable draping system in the prevention of clinical infection within the immediate postoperative period. This study did not demonstrate a clear link between intraoperative culture data and the development of clinical infection. A completely disposable gown and draping system is recommended during implant-based breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000086 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial ID - 10.1097/SAP.0000000000000086 [doi] PP - ppublish LG - English DP - 2014 EZ - 2014/01/01 06:00 DA - 2015/01/06 06:00 DT - 2013/12/31 06:00 YR - 2014 ED - 20150105 RD - 20140519 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24374400 <205. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24374398 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Forsberg CG AU - Kelly DA AU - Wood BC AU - Mastrangelo SL AU - DeFranzo AJ AU - Thompson JT AU - David LR AU - Marks MW FA - Forsberg, Clay G FA - Kelly, David A FA - Wood, Benjamin C FA - Mastrangelo, Stephanie L FA - DeFranzo, Anthony J FA - Thompson, James T FA - David, Lisa R FA - Marks, Malcolm W IN - Forsberg, Clay G. From the *Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, NC; and+Department of Surgery, University of Louisville, Louisville, KY. TI - Aesthetic outcomes of acellular dermal matrix in tissue expander/implant-based breast reconstruction. SO - Annals of Plastic Surgery. 72(6):S116-20, 2014 AS - Ann Plast Surg. 72(6):S116-20, 2014 NJ - Annals of plastic surgery VO - 72 IP - 6 PG - S116-20 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/ep [Epidemiology] MH - Breast Neoplasms/su [Surgery] MH - Comorbidity MH - Humans MH - Male MH - Middle Aged MH - Tissue Expansion MH - Treatment Outcome AB - INTRODUCTION: Tissue expander and implant-based breast reconstruction after mastectomy is the most common method of breast reconstruction. Modifications of the traditional total submuscular reconstruction (TSR) have been made using acellular dermal matrix (ADM) to create an inferolateral sling and a more natural implant pocket for superior aesthetic results. The objective of this study was to assess aesthetic outcomes when using ADM in breast reconstruction. AB - METHODS: A retrospective chart review identified all patients who underwent implant-based breast reconstruction from 2005 to 2009 at our institution. Demographic information, complications, reoperations, and aesthetic outcome data were collected for all patients meeting inclusion criteria related to adequate follow-up and postoperative photographs. Five aesthetic outcomes were evaluated for all study patients by 18 blinded evaluators using postoperative photographs. Outcomes were scored on a scale of 1 to 5, with 5 representing the best possible aesthetic score. AB - RESULTS: A total of 122 patients underwent 183 tissue expander-based reconstructions (ADM, n = 58; TSR, n = 125). The infection rate in patients with ADM was 16.2% compared to 5.9% in TSR patients, but this was not statistically significant (P = 0.09). Capsular contracture was more common in TSR patients (23.5%), compared to those with ADM (8.1%), P = 0.048. Aesthetic scores from the attending plastic surgeons were as follows: natural contour (ADM, 3.36; TSR, 3.02; P = 0.0001), symmetry of shape (ADM, 3.57; TSR, 3.27; P = 0.005), symmetry of size (ADM, 3.68; TSR, 3.42; P = 0.002), position on chest wall (ADM, 3.75; TSR, 3.45; P = 0.004), and overall aesthetic appearance (ADM, 3.56; TSR, 3.20; P = 0.0001). AB - CONCLUSIONS: For all 5 aesthetic parameters evaluated, the ADM group scored significantly higher than the TSR group by 18 blinded evaluators. These consistent findings suggest that the use of ADM in breast reconstruction does confer a significant advantage in aesthetic outcomes for breast reconstruction. This is likely at the cost of a higher infection rate when using ADM; however, that may be offset by the advantage of a lower rate of capsular contracture in patients with ADM. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000000098 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/SAP.0000000000000098 [doi] PP - ppublish LG - English DP - 2014 EZ - 2014/01/01 06:00 DA - 2015/01/06 06:00 DT - 2013/12/31 06:00 YR - 2014 ED - 20150105 RD - 20140519 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24374398 <206. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25357060 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Alderman A AU - Gutowski K AU - Ahuja A AU - Gray D AU - Postmastectomy Expander Implant Breast Reconstruction Guideline Work Group FA - Alderman, Amy FA - Gutowski, Karol FA - Ahuja, Amy FA - Gray, Diedra FA - Postmastectomy Expander Implant Breast Reconstruction Guideline Work Group IN - Alderman, Amy. Arlington Heights, Ill. From the American Society of Plastic Surgeons. TI - ASPS clinical practice guideline summary on breast reconstruction with expanders and implants. SO - Plastic & Reconstructive Surgery. 134(4):648e-55e, 2014 Oct AS - Plast Reconstr Surg. 134(4):648e-55e, 2014 Oct NJ - Plastic and reconstructive surgery VO - 134 IP - 4 PG - 648e-55e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Breast Neoplasms/th [Therapy] MH - Combined Modality Therapy MH - Female MH - Humans MH - *Mammaplasty/st [Standards] MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - *Tissue Expansion Devices AB - LEARNING OBJECTIVES: After reading this article, participants should be able to: 1. Understand the evidence regarding the timing of expander/implant breast reconstruction in the setting of radiation therapy. 2. Discuss the implications of a patient's risk factors for possible outcomes and complications of expander/implant breast reconstruction. 3. Implement proper prophylactic antibiotic protocols. 4. Use the guidelines to improve their own clinical outcomes and reduce complications. AB - SUMMARY: In March of 2013, the Executive Committee of the American Society of Plastic Surgeons approved an evidence-based guideline on breast reconstruction with expanders and implants, as developed by a guideline-specific work group commissioned by the society's Health Policy Committee. The guideline addresses ten clinical questions: patient education, immediate versus delayed reconstruction, risk factors, radiation therapy, chemotherapy, hormonal therapy, antibiotic prophylaxis, acellular dermal matrix, monitoring for cancer recurrence, and oncologic outcomes associated with implant-based reconstruction. The evidence indicates that patients undergoing mastectomy should be offered a preoperative referral to a plastic surgeon. Evidence varies regarding the association between postoperative complications and timing of postmastectomy expander/implant breast reconstruction. Evidence is limited regarding the optimal timing of expand/implant reconstruction in the setting of radiation therapy but suggests that irradiation to the expander or implant is associated with an increased risk of postoperative complications. Evidence also varies regarding the association between acellular dermal matrix and surgical complications in the setting of postmastectomy expander/implant reconstruction. Data support the use of an appropriate preoperative antibiotic, but antibiotics should be discontinued within 24 hours of the procedure, unless a surgical drain is present. Furthermore, postmastectomy expander/implant breast reconstruction does not adversely affect oncologic outcomes. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000541 PT - Journal Article PT - Practice Guideline ID - 10.1097/PRS.0000000000000541 [doi] ID - 00006534-201410000-00044 [pii] PP - ppublish LG - English DP - 2014 Oct EZ - 2014/10/31 06:00 DA - 2014/12/30 06:00 DT - 2014/10/31 06:00 YR - 2014 ED - 20141229 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25357060 <207. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25525481 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Phillips BT AU - Bishawi M AU - Dagum AB AU - Bui DT AU - Khan SU FA - Phillips, Brett T FA - Bishawi, Muath FA - Dagum, Alexander B FA - Bui, Duc T FA - Khan, Sami U IN - Phillips, Brett T. Division of Plastic, Maxillofacial, & Oral Surgery, Duke University Medical Center, Durham, NC. IN - Bishawi, Muath. Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC. IN - Dagum, Alexander B. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook University School of Medicine, Stony Brook, NY. IN - Bui, Duc T. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook University School of Medicine, Stony Brook, NY. IN - Khan, Sami U. Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook University School of Medicine, Stony Brook, NY. TI - A systematic review of infection rates and associated antibiotic duration in acellular dermal matrix breast reconstruction. SO - Eplasty [Electronic Resource]. 14:e42, 2014 AS - Eplasty. 14:e42, 2014 NJ - Eplasty VO - 14 PG - e42 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233926 CP - United States KW - ADM; acellular dermal matrix; antibiotics; breast reconstruction; infection AB - INTRODUCTION: Reported infection rates in breast reconstruction with acellular dermal matrix (ADM) can exceed 31%. Prophylactic antibiotics remain controversial due to the absence of evidence-based literature. The purpose of this study was to examine published antibiotic regimens and their associated infection rates in this population. AB - METHODS: Systematic electronic searches were performed in PubMed, OVID, and the Cochrane databases for studies that reported on prophylactic antibiotic use and infection in patients undergoing ADM breast reconstruction. Two independent authors reviewed studies between 1970 and 2012 for inclusion and data extraction. AB - RESULTS: A total of 863 studies were identified and abstracts reviewed. A total of 24 articles were included, with 2148 patients and 3189 ADM reconstructions. Mean infection rates varied between 0% and 31.25%, with a combined average of 11.59%. When comparing antibiotic protocols of less than 24 hours and more than 24 hours, the average infection rate was 2.48% and 13.21%, respectively. AB - CONCLUSION: The current literature lacks consensus on the necessary duration for postoperative antibiotic prophylaxis following breast reconstruction. The potential increased risk of infection associated with ADM remains controversial. Because of the lack of supportive evidence, we do not recommend prolonged postoperative antibiotics in ADM breast reconstruction. AB - LEVEL OF EVIDENCE: Therapeutic level III evidence. IS - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC4233926 [pmc] PP - epublish LG - English EP - 20141111 DP - 2014 EZ - 2014/12/20 06:00 DA - 2014/12/20 06:01 DT - 2014/12/20 06:00 YR - 2014 ED - 20141219 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25525481 <208. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25493257 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Gunnarsson GL AU - Borsen-Koch M AU - Wamberg P AU - Thomsen JB FA - Gunnarsson, Gudjon Leifur FA - Borsen-Koch, Mikkel FA - Wamberg, Peter FA - Thomsen, Jorn Bo IN - Gunnarsson, Gudjon Leifur. 1 Department of Plastic Surgery, Telemark Hospital, Skien, Norway ; 2 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 3 Department of Surgery Section for Breast Surgery, Lillebaelt Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 4 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 5 Institute of Regional Health Services Research Center Lillebaelt Faculty of Health Sciences University of Southern Denmark, Denmark. IN - Borsen-Koch, Mikkel. 1 Department of Plastic Surgery, Telemark Hospital, Skien, Norway ; 2 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 3 Department of Surgery Section for Breast Surgery, Lillebaelt Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 4 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 5 Institute of Regional Health Services Research Center Lillebaelt Faculty of Health Sciences University of Southern Denmark, Denmark. IN - Wamberg, Peter. 1 Department of Plastic Surgery, Telemark Hospital, Skien, Norway ; 2 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 3 Department of Surgery Section for Breast Surgery, Lillebaelt Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 4 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 5 Institute of Regional Health Services Research Center Lillebaelt Faculty of Health Sciences University of Southern Denmark, Denmark. IN - Thomsen, Jorn Bo. 1 Department of Plastic Surgery, Telemark Hospital, Skien, Norway ; 2 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 3 Department of Surgery Section for Breast Surgery, Lillebaelt Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 4 Department of Plastic Surgery, Lillebaelt Hospital/Odense University Hospital, Kabbeltoft 25, 7100 Vejle, Denmark ; 5 Institute of Regional Health Services Research Center Lillebaelt Faculty of Health Sciences University of Southern Denmark, Denmark. TI - How to perform a NAC sparing mastectomy using an ADM and an implant. SO - Gland Surgery. 3(4):252-7, 2014 Nov AS - Gland surg.. 3(4):252-7, 2014 Nov NJ - Gland surgery VO - 3 IP - 4 PG - 252-7 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244500 CP - China (Republic : 1949- ) KW - Nipple sparing; acellular dermal matrix (ADM); implant; mastectomy; reconstruction AB - BACKGROUND: Preservation of the nipple areolar complex (NAC) provides the optimal conditions for immediate breast reconstruction (IBR). Growing evidence suggests the oncological safety of nipple sparing mastectomy (NSM) when neither NAC nor skin is affected by tumor. This paper presents our initial experience performing NSM and IBR in a selected group of patients through the inframammary incision assisted by hydrodissection. AB - MATERIAL AND METHODS: The study includes 20 healthy women, aged 23-53, and referred for bilateral risk-reducing mastectomy. NSM was carried out using inframammary crease incision assisted by hydrodissection followed by IBR with an acellular dermal matrix (ADM) and an implant as presented in the attached video. Exclusions criteria were hypertension, diabetes, active smoking and previous chest radiation therapy. Data was collected retrospectively. AB - RESULTS: We achieved the reconstructive goal for all 40 breasts (100%). There were no cases of NAC necrosis. Minor complications were registered in two reconstructions (5%), including one case of small partial necrosis and one case of wound dehiscence. The median follow-up was 13 months (range, 1-32 months). AB - CONCLUSIONS: Bilateral risk-reducing NSM and IBR can be successfully achieved through an inframammary crease incision assisted by hydrodissection. Patient selection is the key to a successful outcome. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2014.08.01 PT - Journal Article ID - 10.3978/j.issn.2227-684X.2014.08.01 [doi] ID - gs-03-04-252 [pii] ID - PMC4244500 [pmc] PP - ppublish PH - 2014/07/09 [received] PH - 2014/08/19 [accepted] LG - English DP - 2014 Nov EZ - 2014/12/11 06:00 DA - 2014/12/11 06:01 DT - 2014/12/11 06:00 YR - 2014 ED - 20141210 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25493257 <209. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24692599 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, California. TI - Non-cross-linked porcine acellular dermal matrix in revision breast surgery: long-term outcomes and safety with neopectoral pockets. SO - Aesthetic Surgery Journal. 34(4):551-9, 2014 May 01 AS - Aesthet. surg. j.. 34(4):551-9, 2014 May 01 NJ - Aesthetic surgery journal VO - 34 IP - 4 PG - 551-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast/su [Surgery] MH - *Breast Implantation/ae [Adverse Effects] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Middle Aged MH - Postoperative Complications/di [Diagnosis] MH - Postoperative Complications/et [Etiology] MH - *Postoperative Complications/su [Surgery] MH - Reoperation MH - Retrospective Studies MH - Time Factors MH - Treatment Outcome MH - Young Adult KW - Strattice; breast revision surgery; capsular contracture; implant malposition; mastopexy; porcine acellular dermal matrix; ptosis; revision augmentation; rippling AB - BACKGROUND: Revision breast surgery represents a significant problem among patients who have undergone augmentation mammaplasty. Current techniques do not adequately prevent recurrence, thus requiring novel approaches, including placement of Strattice (LifeCell, Branchburg, New Jersey), a non-cross-linked porcine acellular dermal matrix, to minimize recurrence. AB - OBJECTIVE: The authors review their experience and long-term outcomes with placement of Strattice in revision breast surgery patients who underwent previous augmentation mammaplasty. AB - METHODS: All patients in the authors' practice with a previous history of augmentation mammaplasty who underwent revision breast surgery with placement of Strattice between January 2007 and December 2011, and who had a minimum of 12 months of follow-up, were included in this retrospective study. A total of 106 patients met the study's inclusion criteria. AB - RESULTS: Average patient age was 42.3 years and average follow-up time was 3.1 years. Indications for revision surgery included capsular contracture (51.9%), implant malposition (38.7%), and ptosis (8.5%); approximately 40% had >=1 previous attempts to correct the presenting complaint. Revision surgery included creation of neosubpectoral pockets with retention of previous noncalcified capsules in 81% of patients with subpectoral implants. Presenting complaints were successfully resolved in all patients. The overall complication rate was 0.9%. AB - CONCLUSIONS: Adding Strattice to traditional revision surgery procedures results in reliable, durable repair of the presenting complaint with minimal associated complications. Treatment with Strattice in conjunction with noncalcified capsules retained during site change also appears to be safe. The data support a role for Strattice in revision breast surgery for patients who have undergone previous augmentation mammaplasty. RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X14528207 PT - Journal Article ID - 1090820X14528207 [pii] ID - 10.1177/1090820X14528207 [doi] PP - ppublish LG - English EP - 20140401 DP - 2014 May 01 EZ - 2014/04/03 06:00 DA - 2014/12/15 06:00 DT - 2014/04/03 06:00 YR - 2014 ED - 20141208 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24692599 <210. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24682442 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dent BL AU - Small K AU - Swistel A AU - Talmor M FA - Dent, Briar L FA - Small, Kevin FA - Swistel, Alexander FA - Talmor, Mia IN - Dent, Briar L. Department of Surgery at New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York. TI - Nipple-areolar complex ischemia after nipple-sparing mastectomy with immediate implant-based reconstruction: risk factors and the success of conservative treatment. SO - Aesthetic Surgery Journal. 34(4):560-70, 2014 May 01 AS - Aesthet. surg. j.. 34(4):560-70, 2014 May 01 NJ - Aesthetic surgery journal VO - 34 IP - 4 PG - 560-70 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Administration, Cutaneous MH - Adult MH - Aged MH - Anti-Bacterial Agents/ad [Administration & Dosage] MH - Bacitracin/ad [Administration & Dosage] MH - *Breast Implantation/ae [Adverse Effects] MH - Female MH - Humans MH - Ischemia/di [Diagnosis] MH - Ischemia/dt [Drug Therapy] MH - *Ischemia/et [Etiology] MH - *Mastectomy, Subcutaneous/ae [Adverse Effects] MH - Middle Aged MH - *Nipples/bs [Blood Supply] MH - *Nipples/su [Surgery] MH - Ointments MH - Retrospective Studies MH - Risk Factors MH - Time Factors MH - Treatment Outcome KW - breast reconstruction; complications; conservative treatment; implant-based reconstruction; implants; inframammary fold; ischemia; nipple-areolar complex; nipple-sparing mastectomy; tissue expanders AB - BACKGROUND: Nipple-sparing mastectomy performed via an inframammary fold incision with implant-based reconstruction is an oncologically safe procedure that provides excellent cosmesis. AB - OBJECTIVES: The authors report their experience with conservative treatment of postoperative nipple-areolar complex (NAC) ischemia and an analysis of risk factors for NAC ischemia and conservative treatment failure. AB - METHODS: A retrospective chart review was conducted of 318 nipple-sparing mastectomies performed through inframammary fold incisions with implant-based reconstruction between July 2006 and October 2012. NAC dressings consisted of topical nitroglycerin, external warming for 24 hours, antibacterial petrolatum gauze, and a loose bra for 1 week. Patients were monitored for NAC ischemia as the primary endpoint. NAC ischemia was treated with bacitracin ointment. In cases of full-thickness ischemia, expanders were also partially deflated. AB - RESULTS: Partial- and full-thickness NAC ischemia occurred in 44 (13.8%) and 21 (6.6%) cases, respectively. All partial- and 17 full-thickness cases resolved with conservative treatment. Of these, 7 partial- and 2 full-thickness cases suffered residual depigmentation. Four full-thickness cases required operative debridement. Factors associated with NAC ischemia included increasing age (P = .035), higher body mass index (P = .0009), greater breast volume (P = .0023), and diabetes (P = .0046). Factors associated with conservative treatment failure included increasing age (P < .0001), higher body mass index (P = .014), greater breast volume (P = .020), smoking (P = .0449), acellular dermal matrix use (P < .0001), and single-stage reconstruction (P = .0090). AB - CONCLUSIONS: Postoperative NAC ischemia can be effectively managed conservatively to preserve cosmesis and implant viability. Knowledge of risk factors for NAC ischemia and conservative treatment failure may improve future patient counseling and outcomes. RN - 0 (Anti-Bacterial Agents) RN - 0 (Ointments) RN - 1405-87-4 (Bacitracin) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X14528352 PT - Journal Article ID - 1090820X14528352 [pii] ID - 10.1177/1090820X14528352 [doi] PP - ppublish LG - English EP - 20140328 DP - 2014 May 01 EZ - 2014/04/01 06:00 DA - 2014/12/15 06:00 DT - 2014/04/01 06:00 YR - 2014 ED - 20141208 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24682442 <211. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25426375 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Scheflan M AU - Colwell AS FA - Scheflan, Michael FA - Colwell, Amy S IN - Scheflan, Michael. Assuta and Herzlia Medical Centers, Tel Aviv, Israel; and Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass. IN - Colwell, Amy S. Assuta and Herzlia Medical Centers, Tel Aviv, Israel; and Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass. TI - Tissue Reinforcement in Implant-based Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 2(8):e192, 2014 Aug AS - Plast. reconstr. surg., Glob. open. 2(8):e192, 2014 Aug NJ - Plastic and reconstructive surgery. Global open VO - 2 IP - 8 PG - e192 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236353 CP - United States AB - BACKGROUND: Tissue reinforcement with allogeneic or xenogeneic acellular dermal matrices (ADMs) is increasingly used in single-stage (direct-to-implant) and 2-stage implant-based breast reconstruction following mastectomy. ADMs allow surgeons to control implant position and obviate the need for submuscular implant placement. Here, we review the benefits and risks of using ADMs in implant-based breast reconstruction based on available data. AB - METHODS: A comprehensive analysis of the literature with focus on recent publications was performed. Additional information regarding the proper use of ADMs was based on our institutional experience. AB - RESULTS: ADM use may improve definition of the lateral confines of the breast and lower pole projection. It may facilitate direct-to-implant procedures and improve aesthetic outcomes. The effect of ADMs on complication rates remains controversial. Known patient risk factors such as obesity, smoking, and radiotherapy should be considered during patient selection. For patients with healthy, well-vascularized skin envelopes, ADM-assisted direct-to- implant reconstruction is a safe and cost-effective alternative to 2-stage implant reconstruction, with low complication rates. ADMs may be used to treat capsular contracture, and limited available data further suggest the possibility that ADMs may reduce the risk of capsular contracture. Novel synthetic or biosynthetic tissue reinforcement devices with different physical and ease-of-use properties than ADMs are emerging options for reconstructive surgeons and patients who seek to avoid tissue products from human or mammalian cadavers. AB - CONCLUSIONS: ADM-assisted implant-based breast reconstruction may improve aesthetic outcomes. However, appropriate patient selection, surgical technique, and postoperative management are critical for its success, including minimizing the risk of complications. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000140 PT - Journal Article ID - 10.1097/GOX.0000000000000140 [doi] ID - PMC4236353 [pmc] PP - epublish PH - 2014/04/03 [received] PH - 2014/04/29 [accepted] LG - English EP - 20140908 DP - 2014 Aug EZ - 2014/11/27 06:00 DA - 2014/11/27 06:01 DT - 2014/11/27 06:00 YR - 2014 ED - 20141126 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25426375 <212. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23636114 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Liu DZ AU - Mathes DW AU - Neligan PC AU - Said HK AU - Louie O FA - Liu, Daniel Z FA - Mathes, David W FA - Neligan, Peter C FA - Said, Hakim K FA - Louie, Otway IN - Liu, Daniel Z. From the Department of Surgery, Division of Plastic Surgery, University of Washington School of Medicine, Seattle, Washington. TI - Comparison of outcomes using AlloDerm versus FlexHD for implant-based breast reconstruction. SO - Annals of Plastic Surgery. 72(5):503-7, 2014 May AS - Ann Plast Surg. 72(5):503-7, 2014 May NJ - Annals of plastic surgery VO - 72 IP - 5 PG - 503-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Cellulitis/dt [Drug Therapy] MH - Cellulitis/ep [Epidemiology] MH - Cellulitis/et [Etiology] MH - *Collagen/ad [Administration & Dosage] MH - *Collagen/ae [Adverse Effects] MH - Collagen/tu [Therapeutic Use] MH - Comorbidity MH - Diabetes Mellitus/ep [Epidemiology] MH - Equipment Failure Analysis MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Mastectomy/sn [Statistics & Numerical Data] MH - Middle Aged MH - Multivariate Analysis MH - Obesity/ep [Epidemiology] MH - *Prosthesis Failure/et [Etiology] MH - Retrospective Studies MH - Risk Factors MH - *Skin Transplantation/ae [Adverse Effects] MH - Skin Transplantation/mt [Methods] MH - Smoking/ep [Epidemiology] MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/et [Etiology] MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - Treatment Outcome MH - Wound Healing AB - BACKGROUND: Prosthetic reconstruction using human acellular dermis (ADM) is a common practice in breast reconstruction. AlloDerm and FlexHD are two different forms of ADM, each with unique characteristics. No studies have directly compared the postoperative complications of these 2 products. AB - METHODS: The outcomes of 547 consecutive implant-based breast reconstructions were reviewed. AB - RESULTS: Reconstruction was performed in 382 consecutive women (547 total breasts), employing mostly immediate reconstruction (81%). Mean follow-up was 6.4 months. Among immediate reconstructions, 165 used AlloDerm and 97 used FlexHD. Complications were similar by univariate analysis. In multivariate analysis, smoking and higher initial implant fill were risk factors for delayed healing. The use of FlexHD, single-stage reconstruction, and smoking were independent risk factors for implant loss. AB - CONCLUSIONS: There is no significant difference in the complication rates between AlloDerm and FlexHD in immediate breast reconstruction. Multivariate analysis suggests that FlexHD may be a risk factor for implant loss. RN - 0 (Alloderm) RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e318268a87c PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e318268a87c [doi] PP - ppublish LG - English DP - 2014 May EZ - 2013/05/03 06:00 DA - 2014/12/15 06:00 DT - 2013/05/03 06:00 YR - 2014 ED - 20141124 RD - 20140415 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=23636114 <213. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23503439 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rao SS AU - Seaman BJ AU - Davison SP FA - Rao, Samir S FA - Seaman, Bradley J FA - Davison, Steven P IN - Rao, Samir S. From the *Departments of Plastic Surgery, +Otolaryngology, and ++DAVinci Plastic Surgery, Department of Otolaryngology, Georgetown University, Washington, DC. TI - The acellular dermal matrix onlay graft for areolar reconstruction. SO - Annals of Plastic Surgery. 72(5):508-12, 2014 May AS - Ann Plast Surg. 72(5):508-12, 2014 May NJ - Annals of plastic surgery VO - 72 IP - 5 PG - 508-12 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - *Breast Neoplasms/su [Surgery] MH - Cicatrix/et [Etiology] MH - Cicatrix/pc [Prevention & Control] MH - Feasibility Studies MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - *Nipples/su [Surgery] MH - Patient Satisfaction MH - Skin Transplantation/ae [Adverse Effects] MH - *Skin Transplantation/mt [Methods] MH - Surgical Flaps MH - Suture Techniques MH - Tattooing AB - BACKGROUND: Acellular dermal matrix (ADM) has been well described for use in breast reconstruction. The purpose of this study was to describe a novel use for ADM in areolar reconstruction. AB - METHODS: A total of 19 patients and 24 nipple-areolar complexes of breast cancer or BRCA-positive patients status postmastectomy were treated. After nipple flap reconstruction was completed, the areolar complex was marked at 40-45 mm and de-epithelialized. ADM was reconstituted and cut to size. This was sewn into place as an areolar onlay graft using 5-0 chromic running sutures and a vaseline gauze bolster. AB - RESULTS: All 24 areola re-epithelialized in an average of 8.1 weeks. Graft take was 100% in 23 areolas, while 1 areola had only 75% graft take. Two patients underwent subsequent nipple projection procedures. Sixteen areolas were tattooed for color, with plans to tattoo the others. All patients had satisfactory transition from native skin to nipple-areolar complex. All surveyed patients stated they would undergo the procedure again. Average follow-up was 15.7 months. AB - CONCLUSION: The ADM onlay graft for areolar reconstruction is a feasible addition to the plastic surgeon's armamentarium. The primary benefits of this technique are grafting the donor bed of nipple reconstruction, avoidance of a skin graft donor site wound, and prevention of flattening of the breast dome, as seen with primary closure after nipple flap reconstruction. The cost of ADM must be taken into account ($31 per square centimeter), which could be offset by banking excess ADM at the time of breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e318268a83d PT - Journal Article ID - 10.1097/SAP.0b013e318268a83d [doi] PP - ppublish LG - English DP - 2014 May EZ - 2013/03/19 06:00 DA - 2014/12/15 06:00 DT - 2013/03/19 06:00 YR - 2014 ED - 20141124 RD - 20140415 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=23503439 <214. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25245748 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Siddique K AU - Azmy I FA - Siddique, K FA - Azmy, I IN - Siddique, K. Chesterfield Royal Hospital NHS Foundation Trust, UK. TI - A timesaving technique for shaping of acellular dermal matrix in primary breast reconstruction. SO - Annals of the Royal College of Surgeons of England. 96(7):555-6, 2014 Oct AS - Ann R Coll Surg Engl. 96(7):555-6, 2014 Oct NJ - Annals of the Royal College of Surgeons of England VO - 96 IP - 7 PG - 555-6 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vv, 7506860 IO - Ann R Coll Surg Engl SB - Index Medicus CP - England MH - *Acellular Dermis MH - Esthetics MH - Female MH - Graft Survival MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Subcutaneous/mt [Methods] MH - *Operative Time MH - *Skin Transplantation/mt [Methods] ES - 1478-7083 IL - 0035-8843 DO - https://dx.doi.org/10.1308/rcsann.2014.96.7.555a PT - Journal Article ID - 10.1308/rcsann.2014.96.7.555a [doi] ID - PMC4473456 [pmc] PP - ppublish LG - English DP - 2014 Oct EZ - 2014/09/24 06:00 DA - 2014/12/15 06:00 DT - 2014/09/24 06:00 YR - 2014 ED - 20141121 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25245748 <215. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24337173 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mayer HF AU - Loustau HD FA - Mayer, Horacio F FA - Loustau, Hugo D IN - Mayer, Horacio F. Plastic Surgery Department, Hospital Italiano de Buenos Aires, University of Buenos Aires School of Medicine, Peron 4190, 1st Floor (1181), Buenos Aires, Argentina. horacio.mayer@hospitalitaliano.org.ar. IN - Loustau, Hugo D. Plastic Surgery Department, Hospital Italiano de Buenos Aires, University of Buenos Aires School of Medicine, Peron 4190, 1st Floor (1181), Buenos Aires, Argentina. TI - Capsular grafts and flaps in immediate prosthetic breast reconstruction. SO - Aesthetic Plastic Surgery. 38(1):129-138, 2014 Feb AS - Aesthetic Plast Surg. 38(1):129-138, 2014 Feb NJ - Aesthetic plastic surgery VO - 38 IP - 1 PG - 129-138 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adult MH - *Breast Implantation MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - *Postoperative Complications/su [Surgery] MH - Retrospective Studies MH - *Surgical Flaps AB - BACKGROUND: Patients with previously augmented breasts and a diagnosis of breast cancer who are candidates for immediate prosthetic reconstruction can benefit from capsular tissues used for splinting the position of the pectoralis major muscle. AB - METHODS: A retrospective clinical review of patients with previously augmented breasts who are undergoing mastectomy and immediate prosthetic reconstruction with capsular tissues was undertaken. The bottom of the periprosthetic capsule was tailored in a novel and versatile fashion as grafts or flaps and used as a sling between the pectoralis major and the inframammary fold. AB - RESULTS: Of the 21 patients in this study, 19 had unilateral reconstruction, whereas 2 had bilateral reconstructions. Capsular tissues were harvested as free capsular grafts in 15 cases and raised as a capsular flap in the remaining 8 cases. During the follow-up period, complications were detected in 7 patients (1 seroma, 1 infection, 1 hematoma, 1 superficial epidermolysis, 2 cases of rippling, and 1 mild capsular contracture). AB - CONCLUSIONS: For eligible patients, the use of capsular tissues offers a readily available and cost-effective alternative to acellular dermal matrices with a negligible complication rate. Patient selection is key to ensuring a safe oncologic approach and must be carefully carried out in close collaboration with the breast surgeon. AB - LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-013-0249-3 PT - Journal Article ID - 10.1007/s00266-013-0249-3 [doi] ID - 10.1007/s00266-013-0249-3 [pii] PP - ppublish PH - 2013/09/15 [received] PH - 2013/11/13 [accepted] LG - English EP - 20131214 DP - 2014 Feb EZ - 2013/12/18 06:00 DA - 2014/11/15 06:00 DT - 2013/12/17 06:00 YR - 2014 ED - 20141114 RD - 20170418 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24337173 <216. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24917371 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rundell VL AU - Beck RT AU - Wang CE AU - Gutowski KA AU - Sisco M AU - Fenner G AU - Howard MA FA - Rundell, V L M FA - Beck, R T FA - Wang, C E FA - Gutowski, K A FA - Sisco, M FA - Fenner, G FA - Howard, M A IN - Rundell, V L M. Division of Plastic Surgery, NorthShore University HealthSystem, Evanston, IL, USA. IN - Beck, R T. Division of Plastic Surgery, NorthShore University HealthSystem, Evanston, IL, USA. IN - Wang, C E. Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA; The Center for Clinical Research Informatics, NorthShore University HealthSystem, Evanston, IL, USA. IN - Gutowski, K A. Department of Plastic Surgery, Ohio State University School of Medicine, Columbus, OH, USA. IN - Sisco, M. Division of Plastic Surgery, NorthShore University HealthSystem, Evanston, IL, USA. IN - Fenner, G. Division of Plastic Surgery, NorthShore University HealthSystem, Evanston, IL, USA. IN - Howard, M A. Division of Plastic Surgery, NorthShore University HealthSystem, Evanston, IL, USA. Electronic address: mhoward@northshore.org. TI - Complication prevalence following use of tutoplast-derived human acellular dermal matrix in prosthetic breast reconstruction: a retrospective review of 203 patients. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 67(10):1345-51, 2014 Oct AS - J Plast Reconstr Aesthet Surg. 67(10):1345-51, 2014 Oct NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 67 IP - 10 PG - 1345-51 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis/ae [Adverse Effects] MH - Adult MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - Cellulitis/ep [Epidemiology] MH - Contracture/ep [Epidemiology] MH - Female MH - Humans MH - Phthalazines MH - Retrospective Studies MH - Seroma/ep [Epidemiology] MH - Tissue Expansion Devices KW - Acellular dermal matrix; Breast reconstruction; Complications; Nipple sparing mastectomy AB - Use of human acellular dermal matrix (ADM) during prosthetic breast reconstruction has increased. Several ADM products are available produced by differing manufacturing techniques. It is not known if outcomes vary with different products. This study reports the complication prevalence following use of a tutoplast-derived ADM (T-ADM) in prosthetic breast reconstruction. We performed a retrospective chart review of 203 patients (mean follow-up times 12.2 months) who underwent mastectomy and immediate prosthetic breast reconstruction utilizing T-ADM, recording demographic data, surgical indications and complication (infection, seroma, hematoma, wound healing exceeding three weeks and reconstruction failure). During a four-year period, 348 breast reconstructions were performed Complications occurred in 16.4% of reconstructed breasts. Infection occurred in 6.6% of breast reconstructions (3.7% - major infection, requiring intravenous antibiotics and 2.9% minor infection, requiring oral antibiotics only). Seromas occurred in 3.4% and reconstruction failure occurred in 0.6% of breast reconstructions. Analysis suggested that complication prevalence was significantly higher in patients with a BMI >30 (p = 0.03). The complication profile following T-ADM use is this series is comparable to that reported for with other ADM products. T-ADM appears to be a safe and acceptable option for use in ADM-assisted breast reconstruction. Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (Phthalazines) RN - ZQI909440X (azelastine) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(14)00260-5 DO - https://dx.doi.org/10.1016/j.bjps.2014.05.032 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S1748-6815(14)00260-5 [pii] ID - 10.1016/j.bjps.2014.05.032 [doi] PP - ppublish PH - 2013/10/11 [received] PH - 2014/05/16 [revised] PH - 2014/05/16 [accepted] LG - English EP - 20140528 DP - 2014 Oct EZ - 2014/06/12 06:00 DA - 2014/11/11 06:00 DT - 2014/06/12 06:00 YR - 2014 ED - 20141110 RD - 20140915 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24917371 <217. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24844024 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fan X AU - Tian C AU - Fu Y AU - Li X AU - Deng L AU - Lu Q FA - Fan, Xuejiao FA - Tian, Chunxiang FA - Fu, Yuehe FA - Li, Xiuqun FA - Deng, Li FA - Lu, Qing TI - [Preparation and characterization of acellular adipose tissue matrix]. [Chinese] SO - Chung-Kuo Hsiu Fu Chung Chien Wai Ko Tsa Chih/Chinese Journal of Reparative & Reconstructive Surgery. 28(3):377-83, 2014 Mar AS - Chung Kuo Hsiu Fu Chung Chien Wai Ko Tsa Chih. 28(3):377-83, 2014 Mar NJ - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery VO - 28 IP - 3 PG - 377-83 PI - Journal available in: Print PI - Citation processed from: Print JC - 9425194, cnp IO - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi SB - Index Medicus CP - China MH - *Adipose Tissue/cy [Cytology] MH - Biocompatible Materials MH - Cell Adhesion MH - Cell Culture Techniques MH - Cell Proliferation MH - Cell Separation/mt [Methods] MH - Cells, Cultured MH - *Extracellular Matrix MH - Female MH - Humans MH - Materials Testing MH - Microscopy, Electron, Scanning MH - Staining and Labeling MH - *Stem Cells/cy [Cytology] MH - *Tissue Engineering/mt [Methods] MH - *Tissue Scaffolds AB - OBJECTIVE: To prepare human acellular adipose tissue matrix and to evaluate the cellular compatibility so as to explore a suitable bio-derived scaffold for adipose tissue engineering. AB - METHODS: The adipose tissue was harvested from abdominal skin graft of breast cancer patients undergoing radical mastectomy or modified radical mastectomy, and then was treated with a series of decellularization processes including repeated freeze-thaw, enzyme digestion, and organic solvent extraction. The matrix was examined by histology, immunohistochemistry, DAPI fluorescence staining, and scanning electron microscopy to observe the the removal of cells and to analyze its composition of collagen type IV, laminin, and fibronectin, and microstructure. The 3rd passage human adipose-derived stem cells (hADSCs) were co-cultured with acellular adipose tissue matrix and different concentrations of extracted liquid (100%, 75%, 50%, and 25%). The cytotoxic effects of the matrix were tested by MTT. The biocompatibility of the matrix was detected by live/dead staining and scanning electron microscopy observation. AB - RESULTS: The acellular adipose tissue matrix basically maintains intrinsical morphology. The matrix after acellular treatment consisted of extracellular matrix without any cell components, but there were abundant collagen type I; neither DNA nor lipid residual was detected. Moreover, the collagen was the main component of the matrix which was rich in laminin and fibronectin. At 1, 3, and 5 days after co-cultured with hADSCs, the cytotoxic effect of matrix was grade 0-1. The matrix displayed good cell compatibility and proliferation. AB - CONCLUSION: The acellular adipose tissue matrix prepared by repeated freeze-thaw, enzyme digestion, and organic solvent extraction method remains abundant extracellular matrix and has good cellular compatibility, so it is expected to be an ideal bio-derived scaffold for adipose tissue engineering. RN - 0 (Biocompatible Materials) IS - 1002-1892 IL - 1002-1892 PT - English Abstract PT - Journal Article PP - ppublish LG - Chinese DP - 2014 Mar EZ - 2014/05/23 06:00 DA - 2014/10/31 06:00 DT - 2014/05/22 06:00 YR - 2014 ED - 20141030 RD - 20140521 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24844024 <218. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25068353 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Baxter R FA - Baxter, Richard IN - Baxter, Richard. 6100 219th Street S.W., Suite 290, Mountlake Terrace, Wash. 98043, drbaxter@drbaxter.com. TI - Discussion: Applications of acellular dermal matrix in revision breast reconstruction surgery. CM - Comment on: Plast Reconstr Surg. 2014 Jan;133(1):11-3; PMID: 24374665 CM - Comment on: Plast Reconstr Surg. 2014 Jan;133(1):1-10; PMID: 24105085 SO - Plastic & Reconstructive Surgery. 134(2):323e, 2014 Aug AS - Plast Reconstr Surg. 134(2):323e, 2014 Aug NJ - Plastic and reconstructive surgery VO - 134 IP - 2 PG - 323e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/ae [Adverse Effects] MH - *Postoperative Complications/su [Surgery] MH - *Reoperation/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000335 PT - Comment PT - Letter ID - 10.1097/PRS.0000000000000335 [doi] ID - 00006534-201408000-00047 [pii] PP - ppublish LG - English DP - 2014 Aug EZ - 2014/07/30 06:00 DA - 2014/10/17 06:00 DT - 2014/07/29 06:00 YR - 2014 ED - 20141016 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25068353 <219. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25068319 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hanasono MM FA - Hanasono, Matthew M IN - Hanasono, Matthew M. Houston, Texas From the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center. TI - Discussion: An algorithmic approach for selective acellular dermal matrix use in immediate two-stage breast reconstruction: indications and outcomes. CM - Comment on: Plast Reconstr Surg. 2014 Aug;134(2):178-88; PMID: 25068318 SO - Plastic & Reconstructive Surgery. 134(2):189-90, 2014 Aug AS - Plast Reconstr Surg. 134(2):189-90, 2014 Aug NJ - Plastic and reconstructive surgery VO - 134 IP - 2 PG - 189-90 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Algorithms MH - *Decision Support Techniques MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000328 PT - Comment PT - Journal Article ID - 10.1097/PRS.0000000000000328 [doi] ID - 00006534-201408000-00005 [pii] PP - ppublish LG - English DP - 2014 Aug EZ - 2014/07/30 06:00 DA - 2014/10/17 06:00 DT - 2014/07/29 06:00 YR - 2014 ED - 20141016 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25068319 <220. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25068318 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jordan SW AU - Khavanin N AU - Fine NA AU - Kim JY FA - Jordan, Sumanas W FA - Khavanin, Nima FA - Fine, Neil A FA - Kim, John Y S IN - Jordan, Sumanas W. Chicago, Ill. From the Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine. TI - An algorithmic approach for selective acellular dermal matrix use in immediate two-stage breast reconstruction: indications and outcomes. CM - Comment in: Plast Reconstr Surg. 2014 Aug;134(2):189-90; PMID: 25068319 SO - Plastic & Reconstructive Surgery. 134(2):178-88, 2014 Aug AS - Plast Reconstr Surg. 134(2):178-88, 2014 Aug NJ - Plastic and reconstructive surgery VO - 134 IP - 2 PG - 178-88 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis/ec [Economics] MH - Acellular Dermis/ut [Utilization] MH - *Acellular Dermis MH - Adult MH - *Algorithms MH - Breast Neoplasms/su [Surgery] MH - Chicago MH - Contraindications MH - *Decision Support Techniques MH - Esthetics MH - Female MH - Humans MH - Incidence MH - Logistic Models MH - Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - Retrospective Studies AB - BACKGROUND: Acellular dermal matrix use has gained widespread acceptance--despite higher material costs--because of its ease of use and potential for enhanced cosmesis. The authors developed a resource-sensitive algorithm for selective acellular dermal matrix use with indications and contraindications based on body mass index, breast size, radiation therapy, flap vascularity, and pectoralis anatomy. AB - METHODS: The algorithm incorporates preoperative and intraoperative decision points. Complication rates and aesthetic scores were compared for procedures performed before and after adoption of the algorithm. Multiple logistic regression was used to determine the independent influence of the algorithm on postoperative outcomes. AB - RESULTS: One hundred ninety-three breasts underwent reconstruction before and 179 underwent reconstruction after implementation of the algorithm. Overall complication rates did not differ between the cohorts (22.8 percent versus 20.7 percent; p=0.138). After adjusting for potential confounders, the algorithm did not significantly affect the incidence of infection, seroma, flap necrosis, explantation, or overall complications (all p>0.05). Aesthetic scores were not affected (2.75 of 4 versus 3.03 of 4; p=0.138). Acellular dermal matrix use decreased from 84 percent to 36 percent, resulting in a materials cost savings of $270,000 over the study period. AB - CONCLUSIONS: This algorithm obviated placement of acellular dermal matrix in an estimated 48 percent of immediate tissue-expander reconstructions. Patients treated after adoption of this algorithm experienced similar complication rates and aesthetic outcomes as those who underwent reconstruction before. The authors' preliminary outcomes demonstrate that evidence-based measures can be taken to selectively use acellular dermal matrix without a concomitant worsening of patient outcomes. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000366 PT - Evaluation Studies PT - Journal Article ID - 10.1097/PRS.0000000000000366 [doi] ID - 00006534-201408000-00004 [pii] PP - ppublish LG - English DP - 2014 Aug EZ - 2014/07/30 06:00 DA - 2014/10/17 06:00 DT - 2014/07/29 06:00 YR - 2014 ED - 20141016 RD - 20171116 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=25068318 <221. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25289340 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lee MA AU - Miteff KG FA - Lee, Mark A FA - Miteff, Kirstin G IN - Lee, Mark A. Department of Plastic Surgery, St John of God Hospital, Subiaco, Western Australia, Australia; and Department of Plastic, Reconstructive and Maxillofacial Surgery, Royal Perth Hospital, Perth, Western Australia, Australia. IN - Miteff, Kirstin G. Department of Plastic Surgery, St John of God Hospital, Subiaco, Western Australia, Australia; and Department of Plastic, Reconstructive and Maxillofacial Surgery, Royal Perth Hospital, Perth, Western Australia, Australia. TI - The scarless latissimus dorsi flap provides effective lower pole prosthetic coverage in breast reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 2(5):e147, 2014 May AS - Plast. reconstr. surg., Glob. open. 2(5):e147, 2014 May NJ - Plastic and reconstructive surgery. Global open VO - 2 IP - 5 PG - e147 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174076 CP - United States AB - BACKGROUND: The evolution of surgical breast cancer treatment has led to the oncologically safe preservation of greater amounts of native skin, yet we are still often using flaps with large skin paddles, thereby resulting in significant donor-site scars. This explains the increasing appeal of acellular dermal matrix reconstructions. Acellular dermal matrices can, however, have significant problems, particularly if there is any vascular compromise of the mastectomy skin flaps. We have developed a method of raising the latissimus dorsi flap through the anterior mastectomy incisions without requiring special instruments or repositioning. This can provide autologous vascularized cover of the prosthesis. AB - METHODS: A clear surgical description of the scarless latissimus dorsi flap harvest is provided, and our results of a retrospective cohort review of 20 consecutive patients with 27 traditional latissimus dorsi breast reconstructions were compared with those of 20 consecutive patients with 30 scarless latissimus dorsi breast reconstructions. AB - RESULTS: Operative time, length of stay, and complication rates were reduced in the scarless group. Patients Breast-Q scores were equivalent in each group. The aesthetic assessment was good/excellent in 77% of both groups; however, subscale assessment was better in the scarless group. This was statistically significant (P = 0.0). AB - CONCLUSIONS: Breast reconstruction using the scarless latissimus dorsi flap is time effective, requires no patient repositioning, and uses standard breast instrumentation. It is safe and versatile while reducing the risk of exposed prosthesis if native skin necrosis occurs. It is a vascularized alternative to acellular dermal matrices. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000089 PT - Journal Article ID - 10.1097/GOX.0000000000000089 [doi] ID - PMC4174076 [pmc] PP - epublish PH - 2013/07/31 [received] PH - 2014/02/26 [accepted] LG - English EP - 20140606 DP - 2014 May EZ - 2014/10/08 06:00 DA - 2014/10/08 06:01 DT - 2014/10/08 06:00 YR - 2014 ED - 20141007 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25289340 <222. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25289313 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Yuen JC AU - Yue CJ AU - Erickson SW AU - Cooper S AU - Boneti C AU - Henry-Tillman R AU - Klimberg S FA - Yuen, James C FA - Yue, Connie J FA - Erickson, Stephen W FA - Cooper, Shannon FA - Boneti, Cristiano FA - Henry-Tillman, Ronda FA - Klimberg, Suzanne IN - Yuen, James C. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. IN - Yue, Connie J. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. IN - Erickson, Stephen W. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. IN - Cooper, Shannon. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. IN - Boneti, Cristiano. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. IN - Henry-Tillman, Ronda. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. IN - Klimberg, Suzanne. Division of Plastic Surgery, University of Arkansas for Medical Sciences, Little Rock, Ark.; College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Ark.; Division of Plastic Surgery, University of Alabama, Birmingham, Ala.; and Division of Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, Ark. TI - Comparison between Freeze-dried and Ready-to-use AlloDerm in Alloplastic Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 2(3):e119, 2014 Mar AS - Plast. reconstr. surg., Glob. open. 2(3):e119, 2014 Mar NJ - Plastic and reconstructive surgery. Global open VO - 2 IP - 3 PG - e119 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174145 CP - United States AB - BACKGROUND: AlloDerm, a brand of acellular dermal matrix, is commonly used as an internal hammock to support the tissue expander or permanent implant in breast reconstruction. The aim of our study is to evaluate the complication rates associated with the freeze-dried (FD) AlloDerm and the ready-to-use (RTU) AlloDerm. AB - METHODS: This institutional review board-approved retrospective study involved 103 patients who underwent immediate postmastectomy breast reconstructions from June 2011 to August 2012. The first 51 patients underwent 96 immediate breast reconstructions with FD AlloDerm. The subsequent 52 patients underwent 100 immediate breast reconstructions with RTU AlloDerm. Patient demographics, postoperative complication rates in study cohort, and complication rates stratified by body mass index (BMI) were analyzed. AB - RESULTS: Multiple patient demographics in the 2 cohorts are closely matched (P > 0.05). RTU AlloDerm was associated with higher rates of seroma and cellulitis compared with FD AlloDerm (22.0% vs 18.8%, P = 0.599 and 21.0% vs 12.5%, P = 0.129, respectively). Significantly higher rates of seroma and cellulitis were found in patients with BMI >= 30 compared with BMI < 30 (34.5% vs 9.2%, P < 0.001 and 29.9% vs 6.4%, P < 0.001, respectively). A generalized linear mixed model shows that obesity and RTU AlloDerm are statistically significant predictors of cellulitis (adjusted odds ratio = 10.413, P < 0.001 and adjusted odds ratio = 3.712, P = 0.011, respectively). AB - CONCLUSIONS: Our study demonstrates a clinically higher postoperative complication rate in immediate breast reconstruction with RTU AlloDerm compared with FD AlloDerm and highlights the unfavorable risk factor correlation with significant obesity. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000061 PT - Journal Article ID - 10.1097/GOX.0000000000000061 [doi] ID - PMC4174145 [pmc] PP - epublish PH - 2013/12/15 [received] PH - 2014/01/13 [accepted] LG - English EP - 20140407 DP - 2014 Mar EZ - 2014/10/08 06:00 DA - 2014/10/08 06:01 DT - 2014/10/08 06:00 YR - 2014 ED - 20141007 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25289313 <223. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25289272 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Mitchell RE FA - Mitchell, Robert E IN - Mitchell, Robert E. Aesthetic Surgery of Tulsa, Tulsa, Okla. TI - Porcine acellular dermis-assisted breast reconstruction: influence of adjuvant radiotherapy on complications and outcomes. SO - Plastic and Reconstructive Surgery - Global Open. 1(8):e77, 2013 Nov AS - Plast. reconstr. surg., Glob. open. 1(8):e77, 2013 Nov NJ - Plastic and reconstructive surgery. Global open VO - 1 IP - 8 PG - e77 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186295 CP - United States AB - BACKGROUND: Implant-based reconstruction is the most frequently performed breast reconstruction procedure. A persistent issue with this approach is optimizing outcomes in the setting of radiotherapy. Experimental evidence suggests that acellular dermal matrix use may provide a protective benefit, but clinical evidence is lacking. The purpose of this study was to assess postoperative complications and the effect of radiotherapy on complications and outcomes in women who underwent immediate, porcine acellular dermal matrix (PADM, Strattice)-assisted, implant-based breast reconstruction postmastectomy. AB - METHODS: Patients with at least 1 year of follow-up were included in this retrospective study. Patient charts were reviewed for demographic data, adjunctive therapy use, duration of follow-up, and type and incidence of complications during follow-up. AB - RESULTS: A total of 158 reconstructions were performed in 103 patients. Adjuvant therapy included chemotherapy in 51% of patients and radiotherapy in 25% of breasts. Mean follow-up was 36.2 months. Complications occurred in 17 breasts (10.8%): implant/expander loss (8.2%); infection (5.7%); dehiscence (3.8%); eschar (1.9%); and ischemia, hematoma, and seroma (0.6% each). Nine breasts with complications had been irradiated; all were irradiated prereconstruction. Rate of total complications, implant/expander loss, and dehiscence was significantly higher in irradiated breasts. Breasts irradiated postreconstruction had no complications. AB - CONCLUSIONS: Addition of PADM to implant-based reconstruction is associated with acceptable complication rates comparable to those observed with standard submuscular reconstructions. Complications are increased in the setting of radiotherapy; but PADM use may protect against the adverse effects of postreconstruction radiotherapy. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000000020 PT - Journal Article ID - 10.1097/GOX.0000000000000020 [doi] ID - PMC4186295 [pmc] PP - epublish PH - 2013/07/19 [received] PH - 2013/10/03 [accepted] LG - English EP - 20131206 DP - 2013 Nov EZ - 2014/10/08 06:00 DA - 2014/10/08 06:01 DT - 2014/10/08 06:00 YR - 2013 ED - 20141007 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25289272 <224. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25289245 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Cicilioni OJ Jr AU - Foles VB AU - Sieger B AU - Musselman K FA - Cicilioni, Orlando J Jr FA - Foles, Van Brandon FA - Sieger, Barry FA - Musselman, Kelly IN - Cicilioni, Orlando J Jr. Department of Plastic Surgery, Florida Hospital, Orlando, Fla.; Florida Hospital General Surgery Residency Program, Orlando, Fla.; Department of Infectious Disease, Orlando Health, Orlando, Fla.; and Nursing & Clinical Research, Orlando Cosmetic Surgery, LLC, Orlando, Fla. IN - Foles, Van Brandon. Department of Plastic Surgery, Florida Hospital, Orlando, Fla.; Florida Hospital General Surgery Residency Program, Orlando, Fla.; Department of Infectious Disease, Orlando Health, Orlando, Fla.; and Nursing & Clinical Research, Orlando Cosmetic Surgery, LLC, Orlando, Fla. IN - Sieger, Barry. Department of Plastic Surgery, Florida Hospital, Orlando, Fla.; Florida Hospital General Surgery Residency Program, Orlando, Fla.; Department of Infectious Disease, Orlando Health, Orlando, Fla.; and Nursing & Clinical Research, Orlando Cosmetic Surgery, LLC, Orlando, Fla. IN - Musselman, Kelly. Department of Plastic Surgery, Florida Hospital, Orlando, Fla.; Florida Hospital General Surgery Residency Program, Orlando, Fla.; Department of Infectious Disease, Orlando Health, Orlando, Fla.; and Nursing & Clinical Research, Orlando Cosmetic Surgery, LLC, Orlando, Fla. TI - Mycobacterium fortuitum Infection following Reconstructive Breast Surgery: Differentiation from Classically Described Red Breast Syndrome. SO - Plastic and Reconstructive Surgery - Global Open. 1(7):e50, 2013 Oct AS - Plast. reconstr. surg., Glob. open. 1(7):e50, 2013 Oct NJ - Plastic and reconstructive surgery. Global open VO - 1 IP - 7 PG - e50 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174052 CP - United States AB - BACKGROUND: Red breast syndrome (RBS) has been described as an erythema that may be associated with 2-stage prosthetic reconstructive breast surgery using biologic mesh. RBS is differentiated from infectious cellulitis through absence of fever and laboratory abnormalities and usually has a self-limiting course. There have been no clinical reports on etiology, risk factors, or management of RBS. This report describes patient data that raise the need to rule out mycobacterial infection when RBS is being considered as a diagnosis. AB - METHODS: We present 6 cases of Mycobacterium fortuitum infection occurring after prosthetic breast reconstruction performed with a human-derived acellular dermal matrix, including the timing and course of erythema, laboratory results, treatments used, and long-term outcomes. We also describe the differential diagnoses of RBS in the context of these cases, including emergence of acid-fast bacilli and diagnostic and treatment considerations. Exact two-tailed 95% confidence intervals based on the F-distribution are provided with estimates of the incidence rates of infection. AB - RESULTS: The 6 cases presented here do not fit the typical description of RBS and were caused by mycobacterium infection. Statistical evaluation of the estimated incidence rate of M. fortuitum infection in a patient thought to have RBS, which occurred 100% of the time in this series, revealed a 95% confidence interval of 54.1-100%. AB - CONCLUSIONS: When presented with possible RBS, surgeons must rule out cellulitis, culture for acid-fast bacilli such as mycobacterium species, and then determine the best course of treatment. Patient counseling regarding potential household sources of infection is warranted to minimize postoperative infection risk. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0b013e3182a939ed PT - Journal Article ID - 10.1097/GOX.0b013e3182a939ed [doi] ID - PMC4174052 [pmc] PP - epublish PH - 2013/08/17 [received] PH - 2013/08/17 [accepted] LG - English EP - 20131107 DP - 2013 Oct EZ - 2014/10/08 06:00 DA - 2014/10/08 06:01 DT - 2014/10/08 06:00 YR - 2013 ED - 20141007 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25289245 <225. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25289211 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Baxter RA FA - Baxter, Richard A IN - Baxter, Richard A. Baxter Plastic Surgery, Mountlake Terrace, Wash. TI - Long-term Follow-up with AlloDerm in Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 1(2):1-2, 2013 May AS - Plast. reconstr. surg., Glob. open. 1(2):1-2, 2013 May NJ - Plastic and reconstructive surgery. Global open VO - 1 IP - 2 PG - 1-2 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184054 CP - United States AB - SUMMARY: Little is known about the long-term fate of acellular dermal matrices in breast implant surgery. A 12-year follow-up case with tissue analysis of AlloDerm in revision breast reconstruction reveals retention of graft volume and integration with an organized collagen structure, minimal capsule formation, and little or no indication of inflammation. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0b013e318293a160 PT - Journal Article ID - 10.1097/GOX.0b013e318293a160 [doi] ID - PMC4184054 [pmc] PP - epublish PH - 2013/03/21 [received] PH - 2013/03/22 [accepted] LG - English EP - 20130607 DP - 2013 May EZ - 2013/05/01 00:00 DA - 2013/05/01 00:01 DT - 2014/10/08 06:00 YR - 2013 ED - 20141007 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25289211 <226. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25276645 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Kim SE AU - Jung DW AU - Chung KJ AU - Lee JH AU - Kim TG AU - Kim YH AU - Lee SJ AU - Kang SH AU - Choi JE FA - Kim, Sung-Eun FA - Jung, Dong-Woo FA - Chung, Kyu-Jin FA - Lee, Jun Ho FA - Kim, Tae Gon FA - Kim, Yong-Ha FA - Lee, Soo Jung FA - Kang, Su Hwan FA - Choi, Jung Eun IN - Kim, Sung-Eun. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Jung, Dong-Woo. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Chung, Kyu-Jin. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Lee, Jun Ho. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Kim, Tae Gon. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Kim, Yong-Ha. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Lee, Soo Jung. Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Kang, Su Hwan. Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Choi, Jung Eun. Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea. TI - Immediate direct-to-implant breast reconstruction using anatomical implants. SO - Archives of Plastic Surgery. 41(5):529-34, 2014 Sep AS - Arch. plast. surg.. 41(5):529-34, 2014 Sep NJ - Archives of plastic surgery VO - 41 IP - 5 PG - 529-34 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179357 CP - Korea (South) KW - Breast implantation; Breast implants; Breast neoplasms; Mammoplasty; Mastectomy AB - BACKGROUND: In 2012, a new anatomic breast implant of form-stable silicone gel was introduced onto the Korean market. The intended use of this implant is in the area of aesthetic breast surgery, and many reports are promising. Thus far, however, there have been no reports on the use of this implant for breast reconstruction in Korea. We used this breast implant in breast reconstruction surgery and report our early experience. AB - METHODS: From November 2012 to April 2013, the Natrelle Style 410 form-stable anatomically shaped cohesive silicone gel-filled breast implant was used in 31 breasts of 30 patients for implant breast reconstruction with an acellular dermal matrix. Patients were treated with skin-sparing mastectomies followed by immediate breast reconstruction. AB - RESULTS: The mean breast resection volume was 240 mL (range, 83-540 mL). The mean size of the breast implants was 217 mL (range, 125-395 mL). Breast shape outcomes were considered acceptable. Infection and skin thinning occurred in one patient each, and hematoma and seroma did not occur. Three cases of wound dehiscence occurred, one requiring surgical intervention, while the others healed with conservative treatment in one month. Rippling did not occur. So far, complications such as capsular contracture and malrotation of breast implant have not yet arisen. AB - CONCLUSIONS: By using anatomic breast implants in breast reconstruction, we achieved satisfactory results with aesthetics better than those obtained with round breast implants. Therefore, we concluded that the anatomical implant is suitable for breast reconstruction. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2014.41.5.529 PT - Journal Article ID - 10.5999/aps.2014.41.5.529 [doi] ID - PMC4179357 [pmc] PP - ppublish PH - 2013/09/16 [received] PH - 2014/04/22 [revised] PH - 2014/04/22 [accepted] LG - English EP - 20140915 DP - 2014 Sep EZ - 2014/10/03 06:00 DA - 2014/10/03 06:01 DT - 2014/10/03 06:00 YR - 2014 ED - 20141003 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25276645 <227. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24308736 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kocak E AU - Nagel TW AU - Hulsen JH 3rd AU - Carruthers KH AU - Povoski SP AU - Salgado CJ AU - Chao AH FA - Kocak, Ergun FA - Nagel, Theodore W FA - Hulsen, John H 3rd FA - Carruthers, Katherine H FA - Povoski, Stephen P FA - Salgado, Christopher J FA - Chao, Albert H IN - Kocak, Ergun. Department of Plastic Surgery, The Ohio State University, 915 Olentangy River Road, Suite 2100, Columbus, OH 43212, USA. TI - Biologic matrices in oncologic breast reconstruction after mastectomy. [Review] SO - Expert Review of Medical Devices. 11(1):65-75, 2014 Jan AS - Expert Rev Med Devices. 11(1):65-75, 2014 Jan NJ - Expert review of medical devices VO - 11 IP - 1 PG - 65-75 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101230445 IO - Expert Rev Med Devices SB - Index Medicus CP - England MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty MH - *Mastectomy MH - Postoperative Complications/et [Etiology] MH - *Tissue Scaffolds/ch [Chemistry] AB - As the demand for post-mastectomy breast reconstruction has continued to rise, options for the implantable soft-tissue replacement products which enhance the aesthetic and reconstructive outcome of these procedures has grown as well. While the most common product used in an alloplastic breast reconstruction is an acellular dermal matrix derived from human sources, many other options are currently available, each offering their own unique properties and benefits. This review presents a concise description of each of the biologic matrices currently available and discusses their use in the context of one-stage and two-stage breast reconstructions. ES - 1745-2422 IL - 1743-4440 DO - https://dx.doi.org/10.1586/17434440.2014.864087 PT - Journal Article PT - Review ID - 10.1586/17434440.2014.864087 [doi] PP - ppublish LG - English EP - 20131122 DP - 2014 Jan EZ - 2013/12/07 06:00 DA - 2014/09/30 06:00 DT - 2013/12/07 06:00 YR - 2014 ED - 20140929 RD - 20140116 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24308736 <228. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24409778 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dong J AU - Wu XW AU - Tian FX FA - Dong, Jie FA - Wu, Xiao-Wei FA - Tian, Fang-Xing IN - Dong, Jie. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. IN - Wu, Xiao-Wei. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. IN - Tian, Fang-Xing. Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. TI - [The impact of acellular dermal matrix on complications of breast reconstruction using tissue expander/implant: a meta-analysis]. [Chinese] SO - Zhonghua Zheng Xing Wai Ke Za Zhi. 29(5):356-61, 2013 Sep AS - Zhonghua Zheng Xing Wai Ke Za Zhi. 29(5):356-61, 2013 Sep NJ - Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery VO - 29 IP - 5 PG - 356-61 PI - Journal available in: Print PI - Citation processed from: Print JC - 100957850, dp9 IO - Zhonghua Zheng Xing Wai Ke Za Zhi SB - Index Medicus CP - China MH - *Acellular Dermis MH - Breast Implants/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - *Postoperative Complications/et [Etiology] MH - *Tissue Expansion Devices/ae [Adverse Effects] AB - OBJECTIVE: To analyze the effect of acellular dermal matrix (ADM) on complications of breast reconstruction using tissue expander/implant, and to offer preliminary evidences for ADM clinical application. AB - METHODS: Articles published from Jan. 2010 to Oct. 2012 were searched in Pubmed, EMbase, Science Direct and CNKI database. Literatures were filtrated according to inclusive criteria. Values were extracted from included literatures; factors regarding complications were collected. Meta-analysis was performed with Stata 12. 0. AB - RESULTS: 10 researches were included. Comparing to control group, the pooled odds ratio (OR) of overall complications, infections, hematomas/seromas, explantations are 1.51(P=0.038), 1.91(P=0.032), 1.80(P=0.005) and 2.37 (P=0.138) in ADM group In breast reconstruction using tissue expander/implant, ADM increases the respectively. AB - CONCLUSIONS: occurrence of hematomas/sarcomas as well as risks of infections and overall complications. IS - 1009-4598 IL - 1009-4598 PT - English Abstract PT - Journal Article PT - Meta-Analysis PP - ppublish LG - Chinese DP - 2013 Sep EZ - 2014/01/15 06:00 DA - 2014/09/26 06:00 DT - 2014/01/14 06:00 YR - 2013 ED - 20140925 RD - 20140113 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24409778 <229. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23864532 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Brosious JP AU - Wong N AU - Fowler G AU - Stephenson LL AU - Wang WZ AU - Zamboni WA AU - Taghipour-Khiabani K FA - Brosious, John P FA - Wong, Nancy FA - Fowler, Gia FA - Stephenson, Linda L FA - Wang, Wei Z FA - Zamboni, William A FA - Taghipour-Khiabani, Kayvan IN - Brosious, John P. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. IN - Wong, Nancy. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. IN - Fowler, Gia. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. IN - Stephenson, Linda L. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. IN - Wang, Wei Z. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. IN - Zamboni, William A. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. IN - Taghipour-Khiabani, Kayvan. Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada. TI - Evaluation of AlloMax acellular dermal matrix for objective collagen deposition. SO - Journal of Reconstructive Microsurgery. 30(1):31-4, 2014 Jan AS - J Reconstr Microsurg. 30(1):31-4, 2014 Jan NJ - Journal of reconstructive microsurgery VO - 30 IP - 1 PG - 31-4 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - jvx, 8502670 IO - J Reconstr Microsurg SB - Index Medicus CP - United States MH - *Acellular Dermis/me [Metabolism] MH - Animals MH - *Collagen/me [Metabolism] MH - Dermis/me [Metabolism] MH - Hydroxyproline/me [Metabolism] MH - Male MH - Rats MH - Rats, Wistar MH - *Skin Transplantation MH - *Wound Healing/ph [Physiology] AB - Acellular dermal matrix products are popular in various aspects of surgical reconstruction including hernia repairs and breast reconstructions. The goal of this study was to determine quantitative collagen weights of AlloMax (C. R. Bard, Inc. [Davol], Warwick, RI) and of contralateral dermis for composition comparison. A rehydrated sample of AlloMax was subcutaneously implanted on the dorsum of 18 male Wistar rats. Rats were randomly assigned to groups on the basis of in vivo implant time: 1, 3, and 6 weeks. At the end of the implant time, the AlloMax was removed and a section of contralateral dermis was excised as a control. Hydroxyproline, rat Collagen I and Collagen III, and neoangiogenesis were determined in the sections. The results are reported as mean +/- standard error of the mean. Analysis of variance was used to evaluate the between-group differences. A p value of 0.05 or less was considered significant. Hydroxyproline was significantly increased in the 6-week AlloMax implant (26.19 +/- 1.05 vs. 15.03 +/- 3.29). Collagen I and Collagen III were significantly increased following 3 weeks in vivo (612.5% +/- 98.0 vs. 312.9% +/- 82.7, p < 0.05 Collagen I). Neoangiogenesis was significantly increased at 3 and 6 weeks in vivo (2.3 +/- 0.3 and 1.9 +/- 0.3). Acellular AlloMax was rapidly incorporated into the rat dorsum. The measurement parameters were greater than or equivalent to contralateral dermis in this study. Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. RN - 9007-34-5 (Collagen) RN - RMB44WO89X (Hydroxyproline) ES - 1098-8947 IL - 0743-684X DO - https://dx.doi.org/10.1055/s-0033-1349721 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1055/s-0033-1349721 [doi] PP - ppublish LG - English EP - 20130717 DP - 2014 Jan EZ - 2013/07/19 06:00 DA - 2014/09/10 06:00 DT - 2013/07/19 06:00 YR - 2014 ED - 20140908 RD - 20160526 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=23864532 <230. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24165392 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Zhong T AU - Temple-Oberle C AU - Hofer SO AU - Beber B AU - Semple J AU - Brown M AU - Macadam S AU - Lennox P AU - Panzarella T AU - McCarthy C AU - Baxter N AU - MCCAT Study Group FA - Zhong, Toni FA - Temple-Oberle, Claire FA - Hofer, Stefan O P FA - Beber, Brett FA - Semple, John FA - Brown, Mitchell FA - Macadam, Sheina FA - Lennox, Peter FA - Panzarella, Tony FA - McCarthy, Colleen FA - Baxter, Nancy FA - MCCAT Study Group IN - Zhong, Toni. Division of Plastic & Reconstructive Surgery, University Health Network, Toronto, ON, Canada. toni.zhong@uhn.ca. TI - The Multi Centre Canadian Acellular Dermal Matrix Trial (MCCAT): study protocol for a randomized controlled trial in implant-based breast reconstruction.[Erratum appears in Trials. 2016;17:39 Note: Hofer, Stefan [Corrected to Hofer, Stefan O P]; PMID: 26790621] SO - Trials [Electronic Resource]. 14:356, 2013 Oct 28 AS - Trials. 14:356, 2013 Oct 28 NJ - Trials VO - 14 PG - 356 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101263253 IO - Trials PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842809 SB - Index Medicus CP - England MH - Acellular Dermis/ec [Economics] MH - *Acellular Dermis MH - Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/ec [Economics] MH - *Breast Implantation/is [Instrumentation] MH - Breast Implants/ec [Economics] MH - *Breast Implants MH - Breast Neoplasms/ec [Economics] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Canada MH - Clinical Protocols MH - Cost-Benefit Analysis MH - Female MH - Health Care Costs MH - Humans MH - *Mastectomy MH - Neoplasm Staging MH - Patient Satisfaction MH - Prosthesis Design MH - Quality of Life MH - Quality-Adjusted Life Years MH - *Research Design MH - Surveys and Questionnaires MH - Time Factors MH - Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: The two-stage tissue expander/implant (TE/I) reconstruction is currently the gold standard method of implant-based immediate breast reconstruction in North America. Recently, however, there have been numerous case series describing the use of one-stage direct to implant reconstruction with the aid of acellular dermal matrix (ADM). In order to rigorously investigate the novel application of ADM in one-stage implant reconstruction, we are currently conducting a multicentre randomized controlled trial (RCT) designed to evaluate the impact on patient satisfaction and quality of life (QOL) compared to the two-stage TE/I technique. AB - METHODS/DESIGNS: The MCCAT study is a multicenter Canadian ADM trial designed as a two-arm parallel superiority trial that will compare ADM-facilitated one-stage implant reconstruction compared to two-stage TE/I reconstruction following skin-sparing mastectomy (SSM) or nipple-sparing mastectomy (NSM) at 2 weeks, 6 months, and 12 months. The source population will be members of the mastectomy cohort with stage T0 to TII disease, proficient in English, over the age of 18 years, and planning to undergo SSM or NSM with immediate implant breast reconstruction. Stratified randomization will maintain a balanced distribution of important prognostic factors (study site and unilateral versus bilateral procedures). The primary outcome is patient satisfaction and QOL as measured by the validated and procedure-specific BREAST-Q. Secondary outcomes include short- and long-term complications, long-term aesthetic outcomes using five standardized photographs graded by three independent blinded observers, and a cost effectiveness analysis. AB - DISCUSSION: There is tremendous interest in using ADM in implant breast reconstruction, particularly in the setting of one-stage direct to implant reconstruction where it was previously not possible without the intermediary use of a temporary tissue expander (TE). This unique advantage has led many patients and surgeons alike to believe that one-stage ADM-assisted implant reconstruction should be the procedure of choice and should be offered to patients as the first-line treatment. We argue that it is crucial that this technique be scientifically evaluated in terms of patient selection, surgical technique, complications, aesthetic outcomes, cost-effectiveness, and most importantly patient-reported outcomes before it is promoted as the new gold standard in implant-based breast reconstruction. AB - TRIAL REGISTRATION: ClinicalTrials.gov: NCT00956384. ES - 1745-6215 IL - 1745-6215 DO - https://dx.doi.org/10.1186/1745-6215-14-356 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't ID - 1745-6215-14-356 [pii] ID - 10.1186/1745-6215-14-356 [doi] ID - PMC3842809 [pmc] PP - epublish PH - 2013/04/29 [received] PH - 2013/10/01 [accepted] SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT00956384 SL - https://clinicaltrials.gov/search/term=NCT00956384 LG - English EP - 20131028 DP - 2013 Oct 28 EZ - 2013/10/30 06:00 DA - 2014/09/03 06:00 DT - 2013/10/30 06:00 YR - 2013 ED - 20140902 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24165392 <231. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24927863 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lardi AM AU - Ho-Asjoe M AU - Mohanna PN AU - Farhadi J FA - Lardi, Alessia M FA - Ho-Asjoe, Mark FA - Mohanna, Pari-Naz FA - Farhadi, Jian IN - Lardi, Alessia M. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK; Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland. Electronic address: Alessia.Lardi@usb.ch. IN - Ho-Asjoe, Mark. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK. IN - Mohanna, Pari-Naz. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK. IN - Farhadi, Jian. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK; Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland; Center for Plastic Surgery, Clinic Pyramide at the Lake, Zurich, Switzerland. TI - Immediate breast reconstruction with acellular dermal matrix: factors affecting outcome. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 67(8):1098-105, 2014 Aug AS - J Plast Reconstr Aesthet Surg. 67(8):1098-105, 2014 Aug NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 67 IP - 8 PG - 1098-105 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - Aged MH - Animals MH - Body Mass Index MH - Breast Implants MH - Chemotherapy, Adjuvant/ae [Adverse Effects] MH - Cohort Studies MH - Humans MH - Learning Curve MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Multivariate Analysis MH - Neoadjuvant Therapy MH - Patient Outcome Assessment MH - Postoperative Complications MH - Retrospective Studies MH - Risk Factors MH - Smoking/ae [Adverse Effects] KW - Acellular dermis; Breast reconstruction; Complications; Implant-based; Learning curve; Strattice AB - BACKGROUND: The use of acellular dermal matrix (ADM) for coverage of the lower pole in immediate implant-based breast reconstruction has changed surgeons' practice. We present our experience using a porcine ADM (Strattice), focusing on short-term outcomes, patient selection, and technique adaptations that may influence outcome. AB - METHODS: A two-center, retrospective, cohort study was performed from December 2008 to October 2012 at Guy's and St. Thomas' Hospitals, London, and Clinic Pyramide, Zurich. The study period was divided into two periods: Period 1 which spanned from December 2008 to October 2010 and Period 2 from January 2011 to October 2012 wherein technique adaptations were introduced. Short-term complications after reconstructive surgery were compared between Periods 1 and 2. AB - RESULTS: A total of 149 patients underwent 200 reconstructions (110 one-stage and 90 two-stage) following oncologic (134 breasts) or prophylactic (66 breasts) mastectomy. The mean follow-up was 22.2 months. The total complication rate was 32.5%, including infection, 11.5%; hematoma, 5%; seroma, 10.5%; skin necrosis, 3.5%; and serious wound breakdowns with implant exposure, 1.5%. Complications resulted in 3% requiring an early exchange of implant/expander and in 12.5% requiring explantation. A significant reduction in total complications, infection, implant exposure, and implant loss were noted in Period 2. Multivariate analysis showed time period of surgery (Period 1), single-stage reconstruction, and patient characteristics (mastectomy weight>600 g, or body mass index (BMI)>30, or smoking) to be statistically significant risk factors for the development of postoperative complications. Neoadjuvant chemotherapy showed a trend towards higher complication rates. AB - CONCLUSION: The high rate of early complications in this study was mostly related to patient characteristics and learning curves and highlights the importance of patient selection and technique principles in optimizing the outcome. Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(14)00248-4 DO - https://dx.doi.org/10.1016/j.bjps.2014.05.020 PT - Journal Article PT - Multicenter Study ID - S1748-6815(14)00248-4 [pii] ID - 10.1016/j.bjps.2014.05.020 [doi] PP - ppublish PH - 2013/09/10 [received] PH - 2014/03/27 [revised] PH - 2014/05/03 [accepted] LG - English EP - 20140520 DP - 2014 Aug EZ - 2014/06/15 06:00 DA - 2014/08/27 06:00 DT - 2014/06/15 06:00 YR - 2014 ED - 20140826 RD - 20140630 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24927863 <232. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24867763 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H FA - Sbitany, Hani IN - Sbitany, Hani. University of California, San Francisco, 505 Parnassus Avenue, Suite M-593, San Francisco, Calif. 94143, hani.sbitany@ucsfmedctr.org. TI - Management of the post-breast reconstruction "hyperanimation deformity". SO - Plastic & Reconstructive Surgery. 133(6):897e-898e, 2014 Jun AS - Plast Reconstr Surg. 133(6):897e-898e, 2014 Jun NJ - Plastic and reconstructive surgery VO - 133 IP - 6 PG - 897e-898e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - Cicatrix/pp [Physiopathology] MH - Female MH - Humans MH - *Muscle Contraction MH - Pectoralis Muscles/pa [Pathology] MH - *Pectoralis Muscles/pp [Physiopathology] MH - Pectoralis Muscles/su [Surgery] MH - *Skin Transplantation ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000450 PT - Journal Article ID - 10.1097/PRS.0000000000000450 [doi] ID - 00006534-201406000-00056 [pii] PP - ppublish LG - English DP - 2014 Jun EZ - 2014/05/29 06:00 DA - 2014/08/13 06:00 DT - 2014/05/29 06:00 YR - 2014 ED - 20140812 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24867763 <233. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24867734 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gdalevitch P AU - Ho A AU - Genoway K AU - Alvrtsyan H AU - Bovill E AU - Lennox P AU - Van Laeken N AU - Macadam S FA - Gdalevitch, Perry FA - Ho, Adelyn FA - Genoway, Krista FA - Alvrtsyan, Hasmik FA - Bovill, Esta FA - Lennox, Peter FA - Van Laeken, Nancy FA - Macadam, Sheina IN - Gdalevitch, Perry. Vancouver, British Columbia, Canada From the Division of Plastic and Reconstructive Surgery, University of British Columbia. TI - Direct-to-implant single-stage immediate breast reconstruction with acellular dermal matrix: predictors of failure. SO - Plastic & Reconstructive Surgery. 133(6):738e-747e, 2014 Jun AS - Plast Reconstr Surg. 133(6):738e-747e, 2014 Jun NJ - Plastic and reconstructive surgery VO - 133 IP - 6 PG - 738e-747e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - Logistic Models MH - Middle Aged MH - Patient Selection MH - Postoperative Complications/ep [Epidemiology] MH - Reoperation/sn [Statistics & Numerical Data] MH - Retrospective Studies MH - Risk Factors MH - Treatment Failure AB - BACKGROUND: Direct-to-implant single-stage immediate breast reconstruction using acellular dermal matrix is a cost-effective alternative to two-stage expander-implant reconstruction. The purpose of this study was to identify predictors of direct-to-implant single-stage immediate breast reconstruction failure, defined as need for early (<=6 months) revision surgery. AB - METHODS: The authors conducted a retrospective cohort study of all patients with direct-to-implant single-stage immediate breast reconstruction in 2010 and 2011 at three University of British Columbia hospitals. Data were compared between successful and failed single-stage reconstructions. Predictors of failure were identified using multivariate logistic regression. Patient demographics and complications were compared to a random sample of control patients with two-stage alloplastic reconstruction without acellular dermal matrix. AB - RESULTS: Of 164 breasts that underwent direct-to-implant single-stage immediate breast reconstruction, 52 (31.7 percent) required early revision. Increasing breast cup size was the only significant predictor of early revision compared with bra size A (OR for bra size B, 4.86; C, 4.96; D, 6.01; p < 0.05). Prophylactic mastectomies showed a trend toward successful single stage (OR, 0.47; p = 0.061), whereas smoking history trended toward failure (OR, 1.79; p = 0.065). Mastectomy flap necrosis was significantly higher in direct-to-implant single-stage immediate reconstruction cases compared to two-stage controls. AB - CONCLUSIONS: Direct-to-implant breast reconstruction can be reliably performed in a single stage in patients with small breast size. Increasing breast cup size confers a higher chance of early revision. A two-stage approach may be more cost-effective in larger breasted patients. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000171 PT - Journal Article PT - Multicenter Study ID - 10.1097/PRS.0000000000000171 [doi] ID - 00006534-201406000-00002 [pii] PP - ppublish LG - English DP - 2014 Jun EZ - 2014/05/29 06:00 DA - 2014/08/13 06:00 DT - 2014/05/29 06:00 YR - 2014 ED - 20140812 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24867734 <234. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24867714 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lopez J AU - Prifogle E AU - Nyame TT AU - Milton J AU - May JW Jr FA - Lopez, Joseph FA - Prifogle, Erin FA - Nyame, Theodore T FA - Milton, Jacqueline FA - May, James W Jr IN - Lopez, Joseph. Boston and Waltham, Mass. From Harvard Medical School; the Division of Clinical Studies, TEI Biosciences; the Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital; and the Department of Biostatistics, Boston University School of Public Health. TI - The impact of conflicts of interest in plastic surgery: an analysis of acellular dermal matrix, implant-based breast reconstruction.[Erratum appears in Plast Reconstr Surg. 2014 Aug;134(2):373] SO - Plastic & Reconstructive Surgery. 133(6):1328-34, 2014 Jun AS - Plast Reconstr Surg. 133(6):1328-34, 2014 Jun NJ - Plastic and reconstructive surgery VO - 133 IP - 6 PG - 1328-34 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis/ec [Economics] MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/ec [Economics] MH - *Breast Implantation/mt [Methods] MH - Conflict of Interest MH - Cost-Benefit Analysis MH - Female MH - Humans MH - Logistic Models MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Reoperation MH - *Skin Transplantation MH - Treatment Failure AB - BACKGROUND: Although conflicts of interest in biomedical research have received significant attention, the impact of conflicts of interest on surgical outcomes has not been fully explored. AB - METHODS: A systematic electronic search of the literature was performed for studies that evaluated surgical outcomes in acellular dermal matrix and non-acellular dermal matrix implant-based breast reconstruction. Surgical complications, including infection, seroma, hematoma, necrosis, and explantation, were used as outcome metrics and extracted from studies. Surgical outcomes were then pooled and compared between studies that disclosed conflicts of interest and those that did not disclose conflicts of interest. AB - RESULTS: A total of 776 abstracts were identified, of which only 35 fulfilled the authors' inclusion criteria. Conflicts of interest were reported in 14 of these abstracts (40 percent). The pooled data from studies that reported no conflicts of interest and studies that reported conflicts of interest included a total of 8241 and 5384 breasts and 2852 and 1864 patients, respectively. Considered collectively, surgical complications were less common in studies that reported a conflict of interest than in studies that reported no conflicts of interest. When surgical outcome data were further stratified by acellular dermal matrix use, surgical complications were less common in studies with conflicts of interest when acellular dermal matrix was used. However, when acellular dermal matrix was not used, surgical complications were similar between authors that reported a conflict of interest and those that did not report a conflict of interest. AB - CONCLUSIONS: Self-reported conflicts of interest are common in implant-based breast reconstruction research. Studies authored by groups with conflicts of interest are significantly associated with reporting lower surgical complications and therefore describing positive research findings, especially when industry-marketed products are being used in the study. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000172 PT - Journal Article ID - 10.1097/PRS.0000000000000172 [doi] ID - 00006534-201406000-00004 [pii] PP - ppublish LG - English DP - 2014 Jun EZ - 2014/05/29 06:00 DA - 2014/08/13 06:00 DT - 2014/05/29 06:00 YR - 2014 ED - 20140812 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24867714 <235. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25114623 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Shea-Budgell M AU - Quan ML AU - Mehling B AU - Temple-Oberle C FA - Shea-Budgell, Melissa FA - Quan, May Lynn FA - Mehling, Blair FA - Temple-Oberle, Claire IN - Shea-Budgell, Melissa. CancerControl Alberta, Alberta Health Services; IN - Quan, May Lynn. Division of Surgical Oncology, University of Calgary, Calgary; IN - Mehling, Blair. Division of Plastic Surgery, University of Alberta, Edmonton; IN - Temple-Oberle, Claire. Divisions of Plastic Surgery and Surgical Oncology, Calgary, Alberta. TI - Breast reconstruction following prophylactic or therapeutic mastectomy for breast cancer: Recommendations from an evidence-based provincial guideline. [Review] SO - Plastic Surgery. 22(2):103-11, 2014 AS - Plast Surg (Oakv). 22(2):103-11, 2014 NJ - Plastic surgery (Oakville, Ont.) VO - 22 IP - 2 PG - 103-11 PI - Journal available in: Print PI - Citation processed from: Print JC - 101623618 IO - Plast Surg (Oakv) PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116309 CP - United States KW - Breast cancer; Breast reconstruction; Guideline; Mastectomy AB - The side effects of mastectomy can be significant. Breast reconstruction may alleviate some distress; however, there are currently no provincial recommendations regarding the integration of reconstruction with breast cancer therapy. The purpose of the present article is to provide evidence-based strategies for the management of patients who are candidates for reconstruction. A systematic review of meta-analyses, guidelines, clinical trials and comparative studies published between 1980 and 2013 was conducted using the PubMed and EMBASE databases. Reference lists of publications were manually searched for additional literature. The National Guidelines Clearinghouse and SAGE directory, as well as guideline developers' websites, were also searched. Recommendations were developed based on the available evidence. Reconstruction consultation should be made available for patients undergoing mastectomy. Tumour characteristics, cancer therapy, patient comorbidities, body habitus and smoking history may affect reconstruction outcomes. Although immediate reconstruction should be considered whenever possible, delayed reconstruction is acceptable when immediate is not available or appropriate. The integration of reconstruction and postmastectomy radiotherapy should be addressed in a multidisciplinary setting. The decision as to which type of procedure to perform (autologous or alloplastic with or without acellular dermal matrices) should be left to the discretion of the surgeons and the patient after providing counselling. Skin-sparing mastectomy is safe and appropriate. Nipple-sparing is generally not recommended for patients with malignancy, but could be considered for carefully selected patients. Immediate reconstruction requires resources to coordinate operating room time between the general and plastic surgeons, to provide supplies including acellular dermal matrices, and to develop the infrastructure needed to facilitate multidisciplinary discussions. OA - Publisher: La mastectomie peut avoir des effets secondaires importants. La reconstruction mammaire peut soulager une certaine detresse, mais il n'existe pas de recommandations provinciales sur l'integration de la reconstruction au traitement du cancer du sein. Le present article vise a fournir des strategies fondees sur des donnees probantes sur la prise en charge des patientes candidates a la reconstruction. Les auteurs ont effectue une analyse systematique des meta-analyses, des lignes directrices, des essais cliniques et des etudes comparatives publiees entre 1980 et 2013 obtenus dans les bases de donnees PubMed et EMBASE. Ils ont fait des recherches manuelles dans les listes de reference des publications pour trouver d'autres articles. Ils ont egalement fouille le National Guidelines Clearinghouse et le repertoire SAGE, de meme que les sites Web des developpeurs de lignes directrices. Ils ont fait des recommandations d'apres les donnees probantes disponibles. Les patientes qui subissent une mastectomie devraient profiter d'une consultation sur la reconstruction. Les caracteristiques des tumeurs, le traitement du cancer, les comorbidites des patients, le phenotype corporel et les antecedents de tabagisme peuvent nuire aux resultats de la reconstruction. Meme s'il faut envisager une reconstruction immediate dans la mesure du possible, il est acceptable de la reporter lorsque ce n'est pas possible ou envisageable. Une equipe multidisciplinaire doit discuter de l'integration de la reconstruction et de la radiotherapie apres la mastectomie. Il faut laisser le chirurgien et le patient decider du type d'intervention a privilegier (autologue ou alloplastique, accompagnee ou non de matrices dermiques acellulaires) apres avoir offert des conseils therapeutiques. La mastectomie qui epargne la peau est securitaire et pertinente. Il n'est generalement pas recommande d'epargner le mamelon chez les patientes ayant une tumeur maligne, mais on peut l'envisager aupres de patientes soigneusement selectionnees. Il faut des ressources pour effectuer une reconstruction immediate afin de coordonner le temps operatoire entre les plasticiens generaux et plastiques, de fournir le materiel, y compris les matrices dermiques acellulaires, et de prevoir l'infrastructure necessaire pour faciliter les discussions multidisciplinaires.; Language: French IS - 2292-5503 IL - 2292-5503 PT - Journal Article PT - Review ID - PMC4116309 [pmc] PP - ppublish LG - English DP - 2014 EZ - 2014/08/13 06:00 DA - 2014/08/13 06:01 DT - 2014/08/13 06:00 YR - 2014 ED - 20140812 RD - 20170309 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25114623 <236. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25083434 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Rozen WM AU - Ashton MW FA - Rozen, Warren M FA - Ashton, Mark W IN - Rozen, Warren M. The Taylor Lab, Room E533, Department of Anatomy and Neurosciences, The University of Melbourne, Grattan St, Parkville, 3050, Victoria, Australia. IN - Ashton, Mark W. The Taylor Lab, Room E533, Department of Anatomy and Neurosciences, The University of Melbourne, Grattan St, Parkville, 3050, Victoria, Australia. TI - Radiotherapy and breast reconstruction: oncology, cosmesis and complications. [Review] SO - Gland Surgery. 1(2):119-27, 2012 Aug AS - Gland surg.. 1(2):119-27, 2012 Aug NJ - Gland surgery VO - 1 IP - 2 PG - 119-27 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115692 CP - China (Republic : 1949- ) KW - Implant; adjuvant therapy; breast reconstruction; radiation; reconstructive surgery AB - Breast reconstruction plays a highly important role in the management of patients with breast cancer, from a psycho-social and sexual stand-point. Given that immediate breast reconstruction does not impair the oncologic safety of breast cancer management, with no increase in local recurrence rates, and no delays in the initiation of adjuvant chemotherapy or radiotherapy, the need to balance cosmesis in reconstruction with the oncologic needs of breast cancer patients is no more evident than in the discussion of radiotherapy. Radiotherapy is essential adjuvant therapy in the treatment of breast cancer, with the use of adjuvant radiotherapy widely shown to reduce local recurrence after both partial and total mastectomy and shown to prolong both disease-free and overall survival in patients with nodal disease. In the setting of breast reconstruction, the effects of radiotherapy are potentially two-fold, with consideration required of the impact of breast reconstruction on the administration of and the initiation of radiotherapy, as well as the effects of radiotherapy on operative complications and cosmetic outcome following immediate breast reconstruction. The current editorial piece aims to analyze this balance, contrasting both autologous and implant-based reconstruction. The literature is still evolving as to the relative role of autologous vs. alloplastic reconstruction in the setting of radiotherapy, and the more recent introduction of acellular dermal matrix and other compounds further complicate the evidence. Fat grafting and evolving techniques in breast reconstruction will herald new discussions on this front. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.3978/j.issn.2227-684X.2012.05.02 PT - Journal Article PT - Review ID - 10.3978/j.issn.2227-684X.2012.05.02 [doi] ID - gs-01-02-119 [pii] ID - PMC4115692 [pmc] PP - ppublish PH - 2012/04/22 [received] PH - 2012/05/28 [accepted] LG - English DP - 2012 Aug EZ - 2012/08/01 00:00 DA - 2012/08/01 00:01 DT - 2014/08/02 06:00 YR - 2012 ED - 20140801 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25083434 <237. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24091489 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bank J AU - Phillips NA AU - Park JE AU - Song DH FA - Bank, Jonathan FA - Phillips, Nicole A FA - Park, Julie E FA - Song, David H IN - Bank, Jonathan. Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL, 60637, USA. TI - Economic analysis and review of the literature on implant-based breast reconstruction with and without the use of the acellular dermal matrix. [Review] SO - Aesthetic Plastic Surgery. 37(6):1194-201, 2013 Dec AS - Aesthetic Plast Surg. 37(6):1194-201, 2013 Dec NJ - Aesthetic plastic surgery VO - 37 IP - 6 PG - 1194-201 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis/ec [Economics] MH - Adult MH - Aged MH - *Breast Implantation/ec [Economics] MH - Breast Implantation/mt [Methods] MH - *Breast Implants/ec [Economics] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - *Collagen/ec [Economics] MH - Combined Modality Therapy MH - Cost-Benefit Analysis MH - Databases, Factual MH - Female MH - *Health Care Costs MH - Humans MH - Mammaplasty/ec [Economics] MH - Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Prosthesis Failure MH - Retrospective Studies MH - Risk Assessment MH - Treatment Outcome MH - United States AB - BACKGROUND: Use of the acellular dermal matrix (ADM) in two-stage implant-based breast reconstruction has been widely adopted. Despite an increasing focus on health care costs, few reports have addressed the financial implications of ADM use. This study sought to examine the costs of the two-stage technique with and without ADM, concentrating on the direct variable costs of patient care during the expansion process. AB - METHODS: A retrospective review of a prospectively maintained database was conducted. Data were collected on 132 cases resulting in a second-stage exchange for a permanent implant. The findings showed that AlloDerm was used in 61 reconstructions and Strattice in 23 reconstructions. The primary outcome was the number of fills required to achieve the final expander fill volume. The cost of subsequent patient encounters for expansion was estimated using institutional cost data. AB - RESULTS: The number of fills required to achieve the final volume was higher in the non-ADM group (6.5 +/- 1.7) than in the ADM group (3.6 +/- 1.4) (p < 0.0001). No significant difference was found in the small fill volumes (<350 ml; 5.3 vs. 3.7; p > 0.05). The difference was significant in the larger fill volumes (>500 ml; 8.3 vs. 3.7; p < 0.05). Relative to non-ADM reconstruction, with AlloDerm at current prices, the cost increase ranged from $2,727.75 for large reconstructions to $3,290.25 for small reconstructions ($2,167.75-$2,739.25 with Strattice). AB - CONCLUSION: The use of ADM in two-stage reconstruction reduces the number of visits required for reconstructions with 350 ml or more. However, at current pricings, the direct cost of ADM use does not offset the cost savings from the reduced number of visits. AB - LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-013-0213-2 PT - Comparative Study PT - Journal Article PT - Review ID - 10.1007/s00266-013-0213-2 [doi] PP - ppublish PH - 2013/05/01 [received] PH - 2013/08/29 [accepted] LG - English EP - 20131003 DP - 2013 Dec EZ - 2013/10/05 06:00 DA - 2014/07/17 06:00 DT - 2013/10/05 06:00 YR - 2013 ED - 20140716 RD - 20131111 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24091489 <238. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24987566 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lee CU AU - Clapp AJ AU - Jacobson SR FA - Lee, Christine U FA - Clapp, Allison J FA - Jacobson, Steven R IN - Lee, Christine U. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 Rochester, MN 55905, USA. IN - Clapp, Allison J. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 Rochester, MN 55905, USA. IN - Jacobson, Steven R. Department of Plastic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 Rochester, MN 55905, USA. TI - Imaging Features of AlloDerm() Used in Postmastectomy Breast Reconstructions. SO - Journal of Clinical Imaging Science. 4:19, 2014 AS - J Clin Imaging Sci. 4:19, 2014 NJ - Journal of clinical imaging science VO - 4 PG - 19 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101564708 IO - J Clin Imaging Sci PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060408 CP - India KW - AlloDerm; breast reconstruction; imaging; mastectomy; radiology AB - The purpose of this pictorial essay is to demonstrate the imaging features (ultrasound, mammogram, and magnetic resonance imaging (MRI)) of AlloDerm()(LifeCell Corp.; Branchburg, NJ), an acellular dermal matrix sometimes used in both primary and reconstructive breast surgeries. AlloDerm() is derived from cadaveric dermis and provides an immunologically inert scaffold in tissue reconstruction. Since there is little literature on the imaging of this substance, radiologists may be unfamiliar with its appearance in breast imaging. For this manuscript, ex vivo and in vivo images of AlloDerm() in postmastectomy patients were evaluated using different imaging modalities. The appearance of AlloDerm() can vary based on length of time postsurgery and incorporation into the host. AlloDerm() appears as an isodense to glandular tissue on a mammogram and isoechoic to glandular tissue on ultrasound imaging. On MRI, in comparison with normal breast parenchyma, AlloDerm() is hyperintense on T2-weighted imaging and isointense on T1-weighted imaging and demonstrates mild enhancement. To the best of the authors' knowledge, this is the first multimodality imaging description of AlloDerm() used in postmastectomy patients. The conformation of AlloDerm() at surgical placement and the degree of host cell migration and neoangiogenesis are factors to take into consideration when performing diagnostic evaluations; and, familiarity with the various imaging appearances of AlloDerm() can be helpful to exclude residual or recurrent disease. IS - 2156-7514 IL - 2156-5597 DO - https://dx.doi.org/10.4103/2156-7514.131641 PT - Journal Article ID - 10.4103/2156-7514.131641 [doi] ID - JCIS-4-19 [pii] ID - PMC4060408 [pmc] PP - epublish PH - 2014/01/29 [received] PH - 2014/03/26 [accepted] LG - English EP - 20140429 DP - 2014 EZ - 2014/07/06 06:00 DA - 2014/07/06 06:01 DT - 2014/07/03 06:00 YR - 2014 ED - 20140702 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24987566 <239. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24987526 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Valdatta L AU - Cattaneo AG AU - Pellegatta I AU - Scamoni S AU - Minuti A AU - Cherubino M AI - Cattaneo, Anna Giulia; ORCID: https://orcid.org/0000-0001-5685-3684 AI - Pellegatta, Igor; ORCID: https://orcid.org/0000-0002-7963-4262 FA - Valdatta, Luigi FA - Cattaneo, Anna Giulia FA - Pellegatta, Igor FA - Scamoni, Stefano FA - Minuti, Anna FA - Cherubino, Mario IN - Valdatta, Luigi. Department of Biotechnology & Life Science (DBSV), University of Insubria, 21100 Varese, Italy ; Plastic and Reconstructive Surgery Division, Ospedale di Circolo di Varese, Viale Borri 57, 21100 Varese, Italy. IN - Cattaneo, Anna Giulia. Department of Biotechnology & Life Science (DBSV), University of Insubria, 21100 Varese, Italy. IN - Pellegatta, Igor. Plastic and Reconstructive Surgery Division, Ospedale di Circolo di Varese, Viale Borri 57, 21100 Varese, Italy. IN - Scamoni, Stefano. Plastic and Reconstructive Surgery Division, Ospedale di Circolo di Varese, Viale Borri 57, 21100 Varese, Italy. IN - Minuti, Anna. Department of Biotechnology & Life Science (DBSV), University of Insubria, 21100 Varese, Italy. IN - Cherubino, Mario. Department of Biotechnology & Life Science (DBSV), University of Insubria, 21100 Varese, Italy ; Plastic and Reconstructive Surgery Division, Ospedale di Circolo di Varese, Viale Borri 57, 21100 Varese, Italy. TI - Acellular dermal matrices and radiotherapy in breast reconstruction: a systematic review and meta-analysis of the literature. [Review] SO - Plastic Surgery International Print. 2014:472604, 2014 AS - Plast Surg Int. 2014:472604, 2014 NJ - Plastic surgery international VO - 2014 PG - 472604 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101578808 IO - Plast Surg Int PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055390 CP - United States AB - The increasing use of commercially available acellular dermis matrices for postmastectomy breast reconstruction seems to have simplified the surgical procedure and enhanced the outcome. These materials, generally considered to be highly safe or with only minor contraindications due to the necessary manipulation in preparatory phases, allow an easier one-phase surgical procedure, in comparison with autologous flaps, offering a high patient satisfaction. Unfortunately, the claim for a higher rate of complications associated with irradiation at the implant site, especially when the radiation therapy was given before the reconstructive surgery, suggested a careful behaviour when this technique is preferred. However, this hypothesis was never submitted to a crucial test, and data supporting it are often discordant or incomplete. To provide a comprehensive analysis of the field, we searched and systematically reviewed papers published after year 2005 and registered clinical trials. On the basis of a meta-analysis of data, we conclude that the negative effect of the radiotherapy on the breast reconstruction seems to be evident even in the case of acellular dermis matrices aided surgery. However, more trials are needed to make solid conclusions and clarify the poor comprehension of all the factors negatively influencing outcome. IS - 2090-1461 IL - 2090-1461 DO - https://dx.doi.org/10.1155/2014/472604 PT - Journal Article PT - Review ID - 10.1155/2014/472604 [doi] ID - PMC4055390 [pmc] PP - ppublish PH - 2014/02/04 [received] PH - 2014/04/22 [accepted] LG - English EP - 20140521 DP - 2014 EZ - 2014/07/06 06:00 DA - 2014/07/06 06:01 DT - 2014/07/03 06:00 YR - 2014 ED - 20140702 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24987526 <240. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24445873 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Small K AU - Kelly KM AU - Swistel A AU - Dent BL AU - Taylor EM AU - Talmor M FA - Small, Kevin FA - Kelly, Kathleen M FA - Swistel, Alexander FA - Dent, Briar L FA - Taylor, Erin M FA - Talmor, Mia IN - Small, Kevin. New York, N.Y. From the Division of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medical College. TI - Surgical treatment of nipple malposition in nipple-sparing mastectomy device-based reconstruction. SO - Plastic & Reconstructive Surgery. 133(5):1053-62, 2014 May AS - Plast Reconstr Surg. 133(5):1053-62, 2014 May NJ - Plastic and reconstructive surgery VO - 133 IP - 5 PG - 1053-62 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Implantation/sn [Statistics & Numerical Data] MH - Breast Neoplasms/ep [Epidemiology] MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Carcinoma in Situ/ep [Epidemiology] MH - Carcinoma in Situ/rt [Radiotherapy] MH - Carcinoma in Situ/su [Surgery] MH - Carcinoma, Ductal/ep [Epidemiology] MH - Carcinoma, Ductal/rt [Radiotherapy] MH - *Carcinoma, Ductal/su [Surgery] MH - Carcinoma, Lobular/ep [Epidemiology] MH - Carcinoma, Lobular/rt [Radiotherapy] MH - Carcinoma, Lobular/su [Surgery] MH - Female MH - Humans MH - *Mastectomy, Segmental/ae [Adverse Effects] MH - Mastectomy, Segmental/sn [Statistics & Numerical Data] MH - Middle Aged MH - *Nipples/su [Surgery] MH - *Postoperative Complications/ep [Epidemiology] MH - Reoperation/sn [Statistics & Numerical Data] MH - Retrospective Studies MH - Risk Factors AB - BACKGROUND: This article discusses the senior author's (M.T.) experience with nipple-areola complex malposition following nipple-sparing mastectomy, surgical options for treatment, and an analysis of risk factors. AB - METHODS: A retrospective review was conducted on a prospectively collected institutional review board-approved database of nipple-sparing mastectomy cases with immediate device-based reconstruction performed between July of 2006 and October of 2012. Malposition was graded as mild (1 cm), moderate (2 cm), or severe (>3 cm) displacement. AB - RESULTS: Three hundred nineteen nipple-sparing mastectomies were reviewed. Malposition occurred in 44 (13.79 percent). Significant factors were age (p < 0.0001), diabetes mellitus (p = 0.0025), body mass index (p = 0.0093), preoperative sternal notch-to-nipple distance (p = 0.015), preoperative breast base width (p = 0.0001), periareolar mastectomy incision with lateral extension (p < 0.0001), prior radiation (p = 0.0004), prior lumpectomy (p = 0.0125), unilateral nipple-sparing mastectomy (p = 0.0004), and postoperative nipple-areola complex ischemia (p = 0.0174). Smoking status, breast volume resected, implant size, ablative surgeon, acellular dermal matrix, and single-stage reconstruction were not significant. Nineteen patients were satisfied. Eight were not offered surgical correction because of an inadequate skin envelope. Eight had crescent mastopexy, three had implant exchange and pocket revision, four had free nipple grafts, and two had pedicled nipple transposition. There were no incidences of necrosis or malposition after surgical correction. AB - CONCLUSIONS: Nipple-sparing mastectomy followed by immediate device-based reconstruction has a risk of nipple malposition. Various surgical procedures are available to correct nipple malposition based on clinical presentation and are safe in certain populations. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000000094 PT - Journal Article ID - 10.1097/PRS.0000000000000094 [doi] PP - ppublish LG - English DP - 2014 May EZ - 2014/01/22 06:00 DA - 2014/06/27 06:00 DT - 2014/01/22 06:00 YR - 2014 ED - 20140626 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24445873 <241. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24126333 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ganske I AU - Verma K AU - Rosen H AU - Eriksson E AU - Chun YS FA - Ganske, Ingrid FA - Verma, Kapil FA - Rosen, Heather FA - Eriksson, Elof FA - Chun, Yoon S IN - Ganske, Ingrid. From the *Brigham and Women's Hospital, Boston, MA; +Georgetown University Hospital, Washington, DC; ++Vanderbilt University Medical Center, Nashville, TN; and Brigham and Women's Faulkner Hospital, Boston, MA. TI - Minimizing complications with the use of acellular dermal matrix for immediate implant-based breast reconstruction. SO - Annals of Plastic Surgery. 71(5):464-70, 2013 Nov AS - Ann Plast Surg. 71(5):464-70, 2013 Nov NJ - Annals of plastic surgery VO - 71 IP - 5 PG - 464-70 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Care/mt [Methods] MH - Retrospective Studies MH - Seroma/et [Etiology] MH - *Seroma/pc [Prevention & Control] MH - Surgical Flaps MH - Surgical Wound Infection/et [Etiology] MH - *Surgical Wound Infection/pc [Prevention & Control] MH - *Tissue Expansion/mt [Methods] MH - Treatment Outcome AB - BACKGROUND: Acellular dermal matrix (ADM) use in implant-based breast reconstruction has been associated with higher rates of postoperative seroma and infection. This follow-up study was performed to determine whether specific modifications in technique are associated with a reduction in the rate of complications. AB - METHODS: The authors performed a retrospective analysis of immediate ADM-assisted implant-based breast reconstructions performed by the lead author (Y.C.) during an 18-month period after instituting specific modifications to prevent seroma. These included draining both the submastectomy and sub-ADM planes, lowering the threshold for drain removal, and addition of postoperative soft compression dressings and surgical bras. A total of 179 implant-based reconstructions were evaluated for rates of complications, including infection, hematoma, seroma, and skin flap necrosis. These were compared to results of a series of 150 similar procedures performed by the lead author before institution of the procedural modifications described. AB - RESULTS: Seroma rate decreased from 18.6% to 4.7% (P = 0.0022), and major infection rate decreased from 7% to 1.9% (0.0250). AB - CONCLUSIONS: Although implant-based breast reconstruction using ADM has been associated with increased seroma and possible infection rates, the use of specific clinical practices designed to prevent seroma has minimized our rate of these postoperative complications. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3182a7cc9b PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0b013e3182a7cc9b [doi] ID - 00000637-201311000-00008 [pii] PP - ppublish LG - English DP - 2013 Nov EZ - 2013/10/16 06:00 DA - 2014/06/11 06:00 DT - 2013/10/16 06:00 YR - 2013 ED - 20140610 RD - 20131015 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24126333 <242. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23860816 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Becker H AU - Lind JG 2nd FA - Becker, Hilton FA - Lind, Jeffrey G 2nd IN - Becker, Hilton. Hilton Becker Clinic of Plastic Surgery, 670 Glades Road #220, Boca Raton, FL, 33431, USA, hbecker100@aol.com. TI - The use of synthetic mesh in reconstructive, revision, and cosmetic breast surgery. SO - Aesthetic Plastic Surgery. 37(5):914-21, 2013 Oct AS - Aesthetic Plast Surg. 37(5):914-21, 2013 Oct NJ - Aesthetic plastic surgery VO - 37 IP - 5 PG - 914-21 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778996 SB - Index Medicus CP - United States MH - *Absorbable Implants MH - Acellular Dermis MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Female MH - Humans MH - Male MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Prosthesis Design MH - Reoperation MH - Retrospective Studies MH - *Surgical Mesh MH - Tissue Expansion AB - BACKGROUND: Recent evidence suggests that the use of acellular dermal matrices in prosthetic breast reconstruction, revision, or augmentation may be associated with an increased risk of complications. In this article we report our results of a potential alternative, using a new long-term resorbable synthetic matrix in these cases. AB - METHODS: A retrospective study was performed evaluating 11 primary breast reconstructions (19 breasts), 43 secondary reconstructions (77 breasts), 3 augmentation/augmentation mastopexys (6 breasts), and 5 mastopexys (10 breasts) in 62 patients using TIGR() Matrix Surgical Mesh. AB - RESULTS: Follow-up ranged from 9.4 to 26.1 months with an average follow-up of 16.5 months. Average age was 54 years. The number of patients who had prior radiation was 9 (14.5 %). Four patients (6.5 %) were smokers. Postoperative breast complications included necrosis of two flaps (1.8 %), two seromas requiring drainage (1.8 %), four infection/extrusions (3.6 %), two relapses of inframammary fold/malposition (1.8 %), and two with rippling (1.8 %). Other complications included six cases of asymmetry that required a corrective procedure. In a variety of breast surgery cases very good aesthetic results were achieved. AB - CONCLUSION: The long-term absorbable synthetic matrix, TIGR() Matrix Surgical Mesh, shows potential when used as temporary reinforcement in patients undergoing breast reconstruction or breast surgery revisions and in primary aesthetic procedures, and it appears to be a viable alternative to the use of acellular dermal matrices. ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-013-0171-8 PT - Journal Article ID - 10.1007/s00266-013-0171-8 [doi] ID - PMC3778996 [pmc] PP - ppublish PH - 2012/10/25 [received] PH - 2013/05/26 [accepted] LG - English EP - 20130717 DP - 2013 Oct EZ - 2013/07/19 06:00 DA - 2014/05/31 06:00 DT - 2013/07/18 06:00 YR - 2013 ED - 20140530 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23860816 <243. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23850413 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tamai N AU - Horii M AU - Takehara K AU - Kato S AU - Yamamoto Y AU - Naito A AU - Tayama M AU - Tamahashi Y AU - Nakamura S AU - Kadono T AU - Oe M AU - Nagase T AU - Sanada H FA - Tamai, Nao FA - Horii, Motoko FA - Takehara, Kimie FA - Kato, Shizuko FA - Yamamoto, Yuko FA - Naito, Ayumi FA - Tayama, Mikiko FA - Tamahashi, Yoko FA - Nakamura, Seigo FA - Kadono, Takafumi FA - Oe, Makoto FA - Nagase, Takashi FA - Sanada, Hiromi IN - Tamai, Nao. Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: ntamai-tky@umin.ac.jp. TI - Morphological characteristics of and factors related to moisture-associated dermatitis surrounding malignant wounds in breast cancer patients. SO - European Journal of Oncology Nursing. 17(5):673-80, 2013 Oct AS - EUR J ONCOL NURS. 17(5):673-80, 2013 Oct NJ - European journal of oncology nursing : the official journal of European Oncology Nursing Society VO - 17 IP - 5 PG - 673-80 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100885136 IO - Eur J Oncol Nurs SB - Index Medicus SB - Nursing Journal CP - Scotland MH - Adult MH - Aged MH - Aged, 80 and over MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cross-Sectional Studies MH - *Dermatitis/nu [Nursing] MH - *Dermatitis/pa [Pathology] MH - Evaluation Studies as Topic MH - Exudates and Transudates MH - Female MH - Humans MH - Japan MH - *Mastectomy/ae [Adverse Effects] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/nu [Nursing] MH - Postoperative Complications/pa [Pathology] MH - Prognosis MH - Risk Factors MH - Severity of Illness Index MH - Skin Care/mt [Methods] MH - Surgical Wound Infection/et [Etiology] MH - *Surgical Wound Infection/nu [Nursing] MH - *Surgical Wound Infection/pa [Pathology] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] KW - Breast cancer; Malignant fungating wound; Nursing; Palliative; Qualitative study; Wound care AB - PURPOSE: Patients with malignant breast wounds (MBWs) have multiple symptoms. In particular, care for exudates or peri-wound moisture-associated dermatitis (MAD) is difficult. However, MAD has not been distinguished from peri-wound dermatitis. Therefore, care for patients with MAD has not been well established. The aim of this study was to describe morphological characteristics of MAD in MBWs and link morphological characteristics of MAD to related factors. AB - METHODS: We conducted a qualitative descriptive study and a cross-sectional study. Data were collected by qualitative participant observation and structured interviews. The qualitative descriptive study was conducted using the 'morphoqualitative analysis' method. Data analyses were performed using qualitative research methods. In the cross-sectional study, the participants were classified into 2 groups for comparison: with MAD (MAD group) and without MAD (non-MAD group). AB - RESULTS: Characteristics of 24 MBWs were examined. Morphoqualitative analyses of data generated 17 subcategories and 3 categories. We could morphologically define MAD by findings of 'radial shape matching the dressing' and 'half-fusiform shape over the dressing'. Regarding factors related to MAD, necrotic tissue type was significantly more severe in the MAD group than in the non-MAD group (p = 0.048). Wound exudate leakage was significantly more frequent in the MAD group than in the non-MAD group (p = 0.013). AB - CONCLUSION: Our study provides several points for nursing MBWs. Morphoqualitative analyses of MAD are quite important for evaluating possible causes of MAD as well as selecting effective interventions. Copyright © 2013. Published by Elsevier Ltd. ES - 1532-2122 IL - 1462-3889 DI - S1462-3889(13)00057-4 DO - https://dx.doi.org/10.1016/j.ejon.2013.05.005 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S1462-3889(13)00057-4 [pii] ID - 10.1016/j.ejon.2013.05.005 [doi] PP - ppublish PH - 2013/02/08 [received] PH - 2013/05/11 [revised] PH - 2013/05/14 [accepted] LG - English EP - 20130711 DP - 2013 Oct EZ - 2013/07/16 06:00 DA - 2014/05/21 06:00 DT - 2013/07/16 06:00 YR - 2013 ED - 20140520 RD - 20130916 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23850413 <244. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24829848 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Kasem A AU - Mokbel K FA - Kasem, Abdul FA - Mokbel, Kefah IN - Kasem, Abdul. Abdul Kasem, Kefah Mokbel, London Breast Institute, Princess Grace Hospital, London, W1U 5NY, United Kingdom. IN - Mokbel, Kefah. Abdul Kasem, Kefah Mokbel, London Breast Institute, Princess Grace Hospital, London, W1U 5NY, United Kingdom. TI - Evolving role of skin sparing mastectomy. SO - World Journal of Clinical Oncology. 5(2):33-5, 2014 May 10 AS - World J Clin Oncol. 5(2):33-5, 2014 May 10 NJ - World journal of clinical oncology VO - 5 IP - 2 PG - 33-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 101549149 IO - World J Clin Oncol PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014793 CP - United States KW - Acellular dermal matrix; Breast reconstruction; Flaps; Implants; Skin sparing mastectomy AB - Skin sparing mastectomy (SSM) can facilitate immediate breast reconstruction and is associated with an excellent aesthetic result. The procedure is safe in selected cases; including invasive tumours < 5 cm, multi-centric tumours, ductal carcinoma in situ and for risk-reduction surgery. Inflammatory breast cancers and tumours with extensive involvement of the skin represent contra-indications to SSM due to an unacceptable risk of local recurrence. Prior breast irradiation or the need for post-mastectomy radiotherapy do not preclude SSM, however the aesthetic outcome may be compromised. Preservation of the nipple areola complex is safe for peripherally located node negative tumours. An intraoperative frozen section protocol for the retro-areolar tissue should be considered in these cases. The advent of acellular tissue matrix systems has enhanced the scope of implant-based immediate reconstruction following SSM. Cell-assisted fat transfer is emerging as a promising technique to optimise the aesthetic outcome. IS - 2218-4333 IL - 2218-4333 DO - https://dx.doi.org/10.5306/wjco.v5.i2.33 PT - Journal Article ID - 10.5306/wjco.v5.i2.33 [doi] ID - PMC4014793 [pmc] PP - ppublish PH - 2013/11/09 [received] PH - 2014/02/20 [revised] PH - 2014/03/13 [accepted] LG - English DP - 2014 May 10 EZ - 2014/05/16 06:00 DA - 2014/05/16 06:01 DT - 2014/05/16 06:00 YR - 2014 ED - 20140515 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24829848 <245. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23710792 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Thomsen JB AU - Bille C AU - Wamberg P AU - Jakobsen EH AU - Arffmann S FA - Thomsen, Jorn Bo FA - Bille, Camilla FA - Wamberg, Peter FA - Jakobsen, Erik H FA - Arffmann, Susanne IN - Thomsen, Jorn Bo. Department of Plastic Surgery, Vejle Hospital/Odense University Hospital , Vejle , Denmark. TI - Propeller TAP flap: is it usable for breast reconstruction?. SO - Journal of Plastic Surgery and Hand Surgery. 47(5):379-82, 2013 Oct AS - J Plast Surg Hand Surg. 47(5):379-82, 2013 Oct NJ - Journal of plastic surgery and hand surgery VO - 47 IP - 5 PG - 379-82 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg SB - Index Medicus CP - Sweden MH - Adult MH - Aged MH - Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Denmark MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Patient Satisfaction/sn [Statistics & Numerical Data] MH - *Perforator Flap/bs [Blood Supply] MH - Postoperative Complications/di [Diagnosis] MH - Postoperative Complications/su [Surgery] MH - Preoperative Care MH - Reoperation MH - Risk Assessment MH - Sampling Studies MH - Skin, Artificial MH - Thoracic Arteries/su [Surgery] MH - *Thoracic Arteries/tr [Transplantation] MH - Time Factors MH - Treatment Outcome MH - Ultrasonography, Doppler, Color/mt [Methods] MH - Wound Healing/ph [Physiology] AB - The aim of this study was to examine if a propeller thoracodorsal artery perforator (TAP) flap can be used for breast reconstruction. Fifteen women were reconstructed using a propeller TAP flap, an implant, and an ADM. Preoperative colour Doppler ultrasonography was used for patient selection to identify the dominant perforator in all cases. A total of 16 TAP flaps were performed; 12 flaps were based on one perforator and four were based on two. A permanent silicone implant was used in 14 cases and an expander implant in two. Minor complications were registered in three patients. Two cases had major complications needing additional surgery. One flap was lost due to a vascular problem. Breast reconstruction can be performed by a propeller TAP flap without cutting the descending branch of the thoracodorsal vessels. However, the authors would recommend that a small cuff of muscle is left around the perforator to ensure a sufficient venous return. ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.3109/2000656X.2013.770401 PT - Comparative Study PT - Journal Article ID - 10.3109/2000656X.2013.770401 [doi] PP - ppublish LG - English EP - 20130528 DP - 2013 Oct EZ - 2013/05/29 06:00 DA - 2014/05/10 06:00 DT - 2013/05/29 06:00 YR - 2013 ED - 20140509 RD - 20130916 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23710792 <246. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24615338 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Winters ZE AU - Colwell AS FA - Winters, Z E FA - Colwell, A S IN - Winters, Z E. Breast Cancer Surgery Patient Reported and Clinical Outcomes Research Group, School of Clinical Sciences, University of Bristol, Bristol Breast Care Centre, Southmead Hospital, Bristol BS10 5NB, UK. zoe.winters@bristol.ac.uk. TI - Role of acellular dermal matrix-assisted implants in breast reconstruction. SO - British Journal of Surgery. 101(5):444-5, 2014 Apr AS - Br J Surg. 101(5):444-5, 2014 Apr NJ - The British journal of surgery VO - 101 IP - 5 PG - 444-5 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - b34, 0372553 IO - Br J Surg SB - Core Clinical Journals (AIM) SB - Index Medicus CP - England MH - *Acellular Dermis MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] ES - 1365-2168 IL - 0007-1323 DO - https://dx.doi.org/10.1002/bjs.9415 PT - Journal Article ID - 10.1002/bjs.9415 [doi] PP - ppublish PH - 2013/12/03 [accepted] LG - English EP - 20140224 DP - 2014 Apr EZ - 2014/03/13 06:00 DA - 2014/05/08 06:00 DT - 2014/03/12 06:00 YR - 2014 ED - 20140507 RD - 20140317 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24615338 <247. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24508194 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Krishnan NM AU - Chatterjee A AU - Rosenkranz KM AU - Powell SG AU - Nigriny JF AU - Vidal DC FA - Krishnan, Naveen M FA - Chatterjee, Abhishek FA - Rosenkranz, Kari M FA - Powell, Stephen G FA - Nigriny, John F FA - Vidal, Dale C IN - Krishnan, Naveen M. Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: Naveen.Krishnan07@gmail.com. IN - Chatterjee, Abhishek. Division of Plastic Surgery, Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. IN - Rosenkranz, Kari M. Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. IN - Powell, Stephen G. Tuck School of Business at Dartmouth, Hanover, NH, USA. IN - Nigriny, John F. Division of Plastic Surgery, Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. IN - Vidal, Dale C. Division of Plastic Surgery, Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. TI - The cost effectiveness of acellular dermal matrix in expander-implant immediate breast reconstruction. [Review] SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 67(4):468-76, 2014 Apr AS - J Plast Reconstr Aesthet Surg. 67(4):468-76, 2014 Apr NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 67 IP - 4 PG - 468-76 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - *Breast Implantation/ec [Economics] MH - Breast Implantation/mt [Methods] MH - *Breast Implants/ec [Economics] MH - *Cost-Benefit Analysis MH - Decision Support Techniques MH - Female MH - Humans MH - Mastectomy MH - Middle Aged MH - *Tissue Expansion/ec [Economics] MH - Tissue Expansion/mt [Methods] KW - Acellular dermal matrix; Cost effectiveness analysis AB - BACKGROUND: Expander-implant breast reconstruction is often supplemented with acellular dermal matrix (ADM). The use of acellular dermal matrix has allowed for faster, less painful expansions and improved aesthetics, but with increased cost. Our goal was to provide the first cost utility analysis of using acellular dermal matrix in two-stage, expander-implant immediate breast reconstruction following mastectomy. AB - METHODS: A comprehensive literature review was conducted to identify complication rates for two-stage, expander-implant immediate breast reconstruction with and without acellular dermal matrix. The probabilities of the most common complications were combined with Medicare Current Procedural Terminology reimbursement codes and expert utility estimates to fit into a decision model. The decision model evaluated the cost effectiveness of acellular dermal matrix relative to reconstructions without it. Retail costs for ADM were derived from the LifeCell 2012 company catalogue for Alloderm. AB - RESULTS: The overall complication rates were 30% and 34.5% with and without ADM. The decision model revealed a baseline cost increase of $361.96 when acellular dermal matrix is used. The increase in Quality-Adjusted Life Years (QALYs) is 1.37 in the population with acellular dermal matrix. This yields a cost effective incremental cost-utility ratio (ICUR) of $264.20/QALY. Univariate sensitivity analysis confirmed that using acellular dermal matrix is cost effective even when using retail costs for unilateral and bilateral reconstructions. AB - CONCLUSIONS: Our study shows that, despite an increased cost, acellular dermal matrix is a cost effective technology for patients undergoing two-stage, expander-implant immediate breast reconstruction due to its increased utility in successful procedures. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00699-2 DO - https://dx.doi.org/10.1016/j.bjps.2013.12.035 PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review ID - S1748-6815(13)00699-2 [pii] ID - 10.1016/j.bjps.2013.12.035 [doi] PP - ppublish PH - 2013/02/08 [received] PH - 2013/10/26 [revised] PH - 2013/12/21 [accepted] LG - English EP - 20140123 DP - 2014 Apr EZ - 2014/02/11 06:00 DA - 2014/04/29 06:00 DT - 2014/02/11 06:00 YR - 2014 ED - 20140428 RD - 20140317 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24508194 <248. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24572859 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Patel KM AU - Shuck J AU - Hung R AU - Hannan L AU - Nahabedian MY FA - Patel, Ketan M FA - Shuck, John FA - Hung, Rex FA - Hannan, Lindsay FA - Nahabedian, Maurice Y IN - Patel, Ketan M. Washington, D.C. From the Department of Plastic Surgery, Georgetown University Hospital. TI - Reinforcement of the abdominal wall following breast reconstruction with abdominal flaps: a comparison of synthetic and biological mesh. SO - Plastic & Reconstructive Surgery. 133(3):700-7, 2014 Mar AS - Plast Reconstr Surg. 133(3):700-7, 2014 Mar NJ - Plastic and reconstructive surgery VO - 133 IP - 3 PG - 700-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Abdominal Wall/su [Surgery] MH - *Abdominal Wound Closure Techniques MH - Female MH - Hernia, Ventral/su [Surgery] MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Reconstructive Surgical Procedures MH - Retrospective Studies MH - Surgical Flaps MH - *Surgical Mesh AB - BACKGROUND: Breast reconstruction using muscle-preserving abdominal flaps occasionally results in an abdominal bulge or hernia. The authors analyzed outcomes and complications following use of a synthetic or biological mesh for abdominal reinforcement following initial harvest or secondary repair of a bulge or hernia. AB - METHODS: A retrospective review was conducted of all patients (n = 818) who had abdominal flap-based breast reconstruction between 1995 and 2011. Ninety-seven patients met inclusion criteria; 61 had synthetic mesh and 36 had biological mesh (porcine acellular dermal matrix). Complications and outcomes were reviewed. Statistical analysis was performed to determine contributing factors and differences between cohorts. AB - RESULTS: Overall complication rates for the synthetic and biological cohorts were 6.5 and 5.5 percent (p = 0.61), respectively, with slightly higher bulge rates in patients with synthetic compared with biological mesh (18 percent versus 8.3 percent; p = 0.25). Complication rates in primary and secondary placement of synthetic mesh were 5 and 7.3 percent, respectively; bulge rates were 15 and 19.5 percent, respectively. Complication rates in primary and secondary placement of biological mesh were 6.3 and 0 percent, respectively; bulge rates were 9.4 and 0 percent, respectively. AB - CONCLUSIONS: Synthetic and biological mesh reconstruction for primary abdominal repair and secondary contouring have similar, low complication rates. Postoperative abdominal wall laxity and bulge occurred in an equal distribution following unilateral or bilateral flap reconstruction. Early investigation demonstrates that porcine acellular dermal matrix is as effective as synthetic mesh for abdominal wall reinforcement and repair, with limited morbidity associated with each. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000438047.91139.d5 PT - Comparative Study PT - Journal Article ID - 10.1097/01.prs.0000438047.91139.d5 [doi] ID - 00006534-201403000-00043 [pii] PP - ppublish LG - English DP - 2014 Mar EZ - 2014/02/28 06:00 DA - 2014/04/25 06:00 DT - 2014/02/28 06:00 YR - 2014 ED - 20140424 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24572859 <249. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24572843 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Colwell AS AU - Tessler O AU - Lin AM AU - Liao E AU - Winograd J AU - Cetrulo CL AU - Tang R AU - Smith BL AU - Austen WG Jr FA - Colwell, Amy S FA - Tessler, Oren FA - Lin, Alex M FA - Liao, Eric FA - Winograd, Jonathan FA - Cetrulo, Curtis L FA - Tang, Rong FA - Smith, Barbara L FA - Austen, William G Jr IN - Colwell, Amy S. Boston, Mass. From the Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School. TI - Breast reconstruction following nipple-sparing mastectomy: predictors of complications, reconstruction outcomes, and 5-year trends. SO - Plastic & Reconstructive Surgery. 133(3):496-506, 2014 Mar AS - Plast Reconstr Surg. 133(3):496-506, 2014 Mar NJ - Plastic and reconstructive surgery VO - 133 IP - 3 PG - 496-506 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/td [Trends] MH - *Mastectomy MH - Middle Aged MH - *Nipples/su [Surgery] MH - Retrospective Studies MH - Treatment Outcome AB - BACKGROUND: Nipple-sparing mastectomy is increasingly used for treatment and prevention of breast cancer. Few data exist on risk factors for complications and reconstruction outcomes. AB - METHODS: A single-institution retrospective review was performed between 2007 and 2012. AB - RESULTS: Two hundred eighty-five patients underwent 500 nipple-sparing mastectomy procedures for breast cancer (46 percent) or risk reduction (54 percent). The average body mass index was 24, and 6 percent were smokers. The mean follow-up was 2.17 years. Immediate breast reconstruction (reconstruction rate, 98.8 percent) was performed with direct-to-implant (59 percent), tissue expander/implant (38 percent), or autologous (2 percent) reconstruction. Acellular dermal matrix was used in 71 percent and mesh was used in 11 percent. Seventy-seven reconstructions had radiotherapy. Complications included infection (3.3 percent), skin necrosis (5.2 percent), nipple necrosis (4.4 percent), seroma (1.7 percent), hematoma (1.7 percent), and implant loss (1.9 percent). Positive predictors for total complications included smoking (OR, 3.3; 95 percent CI, 1.289 to 8.486) and periareolar incisions (OR, 3.63; 95 percent CI, 1.850 to 7.107). Increasing body mass index predicted skin necrosis (OR, 1.154; 95 percent CI, 1.036 to 1.286) and preoperative irradiation predicted nipple necrosis (OR, 4.86; 95 percent CI, 1.0197 to 23.169). An inframammary fold incision decreased complications (OR, 0.018; 95 percent CI, 0.0026 to 0.12089). Five-year trends showed increasing numbers of nipple-sparing mastectomy with immediate reconstruction and more single-stage versus two-stage reconstructions (p < 0.05). AB - CONCLUSIONS: Nipple-sparing mastectomy reconstructions have a low number of complications. Smoking, body mass index, preoperative irradiation, and incision type were predictors of complications. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000438056.67375.75 PT - Journal Article ID - 10.1097/01.prs.0000438056.67375.75 [doi] ID - 00006534-201403000-00008 [pii] PP - ppublish LG - English DP - 2014 Mar EZ - 2014/02/28 06:00 DA - 2014/04/25 06:00 DT - 2014/02/28 06:00 YR - 2014 ED - 20140424 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24572843 <250. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24738030 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Vashi C FA - Vashi, Christopher IN - Vashi, Christopher. The Plastic Surgery Group, Chapel Place II, 340 Thomas More Parkway, Crestview Hills, KY 41017, USA ; The Plastic Surgery Group of Greater Cincinnati, 4850 Red Bank Expressway, Cincinnati, OH 45227, USA. TI - Clinical Outcomes for Breast Cancer Patients Undergoing Mastectomy and Reconstruction with Use of DermACELL, a Sterile, Room Temperature Acellular Dermal Matrix. SO - Plastic Surgery International Print. 2014:704323, 2014 AS - Plast Surg Int. 2014:704323, 2014 NJ - Plastic surgery international VO - 2014 PG - 704323 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101578808 IO - Plast Surg Int PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967821 CP - United States AB - Background. Decellularized human skin has been used in a variety of medical applications, primarily involving soft tissue reconstruction, wound healing, and tendon augmentation. Theoretically, decellularization removes potentially immunogenic material and provides a clean scaffold for cellular and vascular in growth. The use of acellular dermal matrix in two-stage postmastectomy breast reconstruction is described. Methods. Ten consecutive breast cancer patients were treated with mastectomies and immediate reconstruction from August to November 2011. There were 8 bilateral and 1 unilateral mastectomies for a total of 17 breasts, with one exclusion for chronic tobacco use. Reconstruction included the use of a new 6 x 16cm sterile, room temperature acellular dermal matrix patch (DermACELL) soaked in a cefazolin bath. Results. Of the 17 breasts, 15 reconstructions were completed; 14 of them with expander to implant sequence and acellular dermal matrix. Histological analysis of biopsies obtained during trimming of the matrix at the second stage appeared nonremarkable with evidence of normal healing, cellularity, and vascular infiltration. Conclusion. Postoperative observations showed that this cellular dermal matrix appears to be an appropriate adjunct to reconstruction with expanders. This acellular dermal matrix appeared to work well with all patients, even those receiving postoperative chemotherapy, postoperative radiation, prednisone, or warfarin sodium. IS - 2090-1461 IL - 2090-1461 DO - https://dx.doi.org/10.1155/2014/704323 PT - Journal Article ID - 10.1155/2014/704323 [doi] ID - PMC3967821 [pmc] PP - ppublish PH - 2014/01/06 [received] PH - 2014/02/07 [revised] PH - 2014/02/07 [accepted] LG - English EP - 20140311 DP - 2014 EZ - 2014/04/17 06:00 DA - 2014/04/17 06:01 DT - 2014/04/17 06:00 YR - 2014 ED - 20140416 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24738030 <251. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23975284 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Torstenson T AU - Boughey JC AU - Saint-Cyr M FA - Torstenson, Tiffany FA - Boughey, Judy C FA - Saint-Cyr, Michel IN - Torstenson, Tiffany. Department of Surgery, Mayo Clinic, Rochester, MN, USA. TI - Inferior dermal flap in immediate breast reconstruction. SO - Annals of Surgical Oncology. 20(10):3349, 2013 Oct AS - Ann Surg Oncol. 20(10):3349, 2013 Oct NJ - Annals of surgical oncology VO - 20 IP - 10 PG - 3349 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - b9r, 9420840 IO - Ann. Surg. Oncol. SB - Index Medicus CP - United States MH - *Breast Neoplasms/su [Surgery] MH - *Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - *Dermis/tr [Transplantation] MH - Female MH - Humans MH - *Mammaplasty MH - Middle Aged MH - Prognosis MH - *Surgical Flaps AB - BACKGROUND: The inferior dermal flap can be used in conjunction with implants or tissue expanders to avoid need for acellular dermal matrix in breast reconstruction and on occasion can serve as an alternative to an autologous flap by functioning as a reconstructed breast mound. Candidates for this procedure are women with high BMI or breast ptosis who desire a decrease in breast size at time of mastectomy with reconstruction. This procedure recruits the de-epithelialized excess skin inferiorly and laterally from a skin-sparing mastectomy and uses this to eliminate the need for acellular dermal matrix in a cost-conscious environment. AB - METHODS: The skin-sparing mastectomy is performed, and the inferior skin flap is de-epithelialized to create the inferior dermal pedicle. A gel implant is placed retropectorally, and the inferior dermal flap is sutured to the inferior border of the pectoralis major muscle and laterally to a muscle-sparing serratus pedicle to provide support and coverage of the implant. AB - RESULTS: We have performed this procedure in several patients and present a video outlining the technique of this procedure in a 54-year-old female diagnosed with left breast DCIS. Postoperative pictures taken at 6 weeks showed an excellent cosmetic result without complications. AB - CONCLUSIONS: The inferior dermal flap is a simple and reproducible procedure that can reduce cost by eliminating the use of acellular dermal matrix. It provides an excellent cosmetic outcome in women undergoing mastectomy with large BMI and breast ptosis seeking reduction in breast size. ES - 1534-4681 IL - 1068-9265 DO - https://dx.doi.org/10.1245/s10434-013-3109-0 PT - Case Reports PT - Journal Article ID - 10.1245/s10434-013-3109-0 [doi] PP - ppublish PH - 2013/03/11 [received] LG - English EP - 20130822 DP - 2013 Oct EZ - 2013/08/27 06:00 DA - 2014/04/16 06:00 DT - 2013/08/27 06:00 YR - 2013 ED - 20140415 RD - 20130904 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23975284 <252. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23788150 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Michelotti BF AU - Brooke S AU - Mesa J AU - Wilson MZ AU - Moyer K AU - Mackay DR AU - Neves RI AU - Potochny J FA - Michelotti, Brett F FA - Brooke, Sebastian FA - Mesa, John FA - Wilson, Matthew Z FA - Moyer, Kurtis FA - Mackay, Donald R FA - Neves, Rogerio I FA - Potochny, John IN - Michelotti, Brett F. Division of Plastic Surgery, Department of Surgery, Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, USA. TI - Analysis of clinically significant seroma formation in breast reconstruction using acellular dermal grafts. SO - Annals of Plastic Surgery. 71(3):274-7, 2013 Sep AS - Ann Plast Surg. 71(3):274-7, 2013 Sep NJ - Annals of plastic surgery VO - 71 IP - 3 PG - 274-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - Adult MH - Aged MH - Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - *Collagen/ae [Adverse Effects] MH - Drainage MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - Logistic Models MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/th [Therapy] MH - Retrospective Studies MH - Risk Factors MH - Seroma/ep [Epidemiology] MH - *Seroma/et [Etiology] MH - Seroma/th [Therapy] MH - Tissue Expansion/is [Instrumentation] MH - Tissue Expansion Devices MH - Treatment Outcome AB - With a rise in tissue expander-based breast reconstructions (TEBRs) using acellular dermal matrix (ADM), we have seen an increase in ADM-specific complications. In this study, we aimed to evaluate clinically significant seroma (CSS) formation-defined by the need for a drainage procedure-to determine if there was a difference in incidence between product types: AlloDerm (AL), DermaMatrix (DM), and FlexHD (FHD). This was a retrospective review of consecutive patients who underwent TEBR at a single institution. The total number of reconstructed breasts was separated into the following 4 groups according to the product type: AL, DM, FHD, or no ADM. We identified the total number of CSSs and compared these data between product types. A logistic regression was performed in an attempt to identify independent risk factors associated with seroma formation. In total, we identified 284 consecutive TEBRs. Overall, there were 17 (7.7%) seromas in 220 breast reconstructions in which ADM was used. When comparing the number of CSS between groups-AL (n = 2, 4.0%), DM (n = 6, 5.4%), FHD (n = 9, 14.75%), and no ADM (n = 1, 1.5%)-we found a significant difference in seroma incidence between product types (P = 0.016). Multivariate analysis identified a strong trend toward FHD as an independent predictor of seroma formation (P = 0.061). Our review suggests that there is strong trend in CSS formation with the use of FHD as compared to other product types and reconstructions in which no ADM was used. RN - 0 (Alloderm) RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3182923dc9 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e3182923dc9 [doi] PP - ppublish LG - English DP - 2013 Sep EZ - 2013/06/22 06:00 DA - 2014/04/12 06:00 DT - 2013/06/22 06:00 YR - 2013 ED - 20140411 RD - 20130814 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23788150 <253. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23710783 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Israeli Ben-Noon H AU - Farber N AU - Weissman O AU - Tessone A AU - Stavrou D AU - Shabtai M AU - Maor Y AU - Haik J AU - Winkler E FA - Israeli Ben-Noon, Hadar FA - Farber, Nimrod FA - Weissman, Oren FA - Tessone, Ariel FA - Stavrou, Demetris FA - Shabtai, Moshe FA - Maor, Yasmin FA - Haik, Joseph FA - Winkler, Eyal IN - Israeli Ben-Noon, Hadar. Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel-Hashomer, Israel. israelihmd@gmail.com TI - The effect of acellular dermal matrix on drain secretions after immediate prosthetic breast reconstruction. SO - Journal of Plastic Surgery and Hand Surgery. 47(4):308-12, 2013 Sep AS - J Plast Surg Hand Surg. 47(4):308-12, 2013 Sep NJ - Journal of plastic surgery and hand surgery VO - 47 IP - 4 PG - 308-12 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg SB - Index Medicus CP - Sweden MH - Adult MH - Analysis of Variance MH - Antibiotic Prophylaxis MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Case-Control Studies MH - Chi-Square Distribution MH - Evaluation Studies as Topic MH - Female MH - Follow-Up Studies MH - Humans MH - Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Preoperative Care MH - Prospective Studies MH - Prosthesis Failure MH - Risk Assessment MH - Skin Transplantation/mt [Methods] MH - *Skin, Artificial MH - Statistics, Nonparametric MH - *Suction/mt [Methods] MH - Time Factors MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - In recent years the acellular dermal matrix (ADM) has gained popularity in prosthetic breast reconstruction. These procedures involve placement of a closed suction drain in the reconstructed breast. Although it is now widely accepted that ADM has an overall positive effect on the outcome of breast reconstruction, data regarding its effect on postoperative drain secretions is lacking. This study was designed to quantitatively evaluate the influence of ADM on postoperative drain secretions in the setting of immediate prosthetic breast reconstruction (IPBR). This is a prospective, comparative controlled study. Two groups of 16 patients each underwent skin sparing mastectomies (SSM) and IPBR with or without ADM. Closed suction drains were left in all the reconstructed breasts and daily secretion volumes were recorded and compared. Postoperative complications were also noted. Patients in the ADM group showed higher daily and overall secretion volumes compared with patients in the control group (p = 0.014) and the time for removal of the drains was higher by an average of 5 days (13 compared with 8 days, respectively; p = 0.004). There was no correlation between ADM and infection. This study provides the first objective evidence that ADM contributes to elevated and prolonged drain secretions when used for IPBR. This might affect possible prosthesis-related complications (e.g., rotation and malposition, capsular contraction, seroma formation, and infection). This study also noted erythema of the post-mastectomy skin flaps in selected patients, which may be attributable to a local inflammatory reaction to the ADM rather than infection. ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.3109/2000656X.2013.766202 PT - Comparative Study PT - Journal Article ID - 10.3109/2000656X.2013.766202 [doi] PP - ppublish LG - English EP - 20130528 DP - 2013 Sep EZ - 2013/05/29 06:00 DA - 2014/04/09 06:00 DT - 2013/05/29 06:00 YR - 2013 ED - 20140408 RD - 20130819 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23710783 <254. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24469217 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tessler O AU - Reish RG AU - Maman DY AU - Smith BL AU - Austen WG Jr FA - Tessler, Oren FA - Reish, Richard G FA - Maman, Daniel Y FA - Smith, Barbara L FA - Austen, William G Jr IN - Tessler, Oren. Boston, Mass. From the Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School. TI - Beyond biologics: absorbable mesh as a low-cost, low-complication sling for implant-based breast reconstruction. CM - Comment in: Plast Reconstr Surg. 2014 Aug;134(2):323e-324e; PMID: 25068354 SO - Plastic & Reconstructive Surgery. 133(2):90e-9e, 2014 Feb AS - Plast Reconstr Surg. 133(2):90e-9e, 2014 Feb NJ - Plastic and reconstructive surgery VO - 133 IP - 2 PG - 90e-9e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Absorbable Implants/ae [Adverse Effects] MH - *Absorbable Implants/ec [Economics] MH - Adult MH - Aged MH - Biocompatible Materials MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/ec [Economics] MH - *Breast Implantation/mt [Methods] MH - Costs and Cost Analysis MH - Female MH - Humans MH - Middle Aged MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Surgical Mesh/ae [Adverse Effects] MH - *Surgical Mesh/ec [Economics] AB - BACKGROUND: There is an intense push to decrease overall healthcare costs in the United States. Although the use of acellular dermal matrix in implant-based reconstruction has grown significantly over the past decade, potential drawbacks remain a source of debate. Matrices are costly and not universally available across institutions, whereas Vicryl mesh is widely available, relatively inexpensive, and resistant to bacteria biofilm formation. With the intent of maximizing the reconstructive and economic advantages of direct-to-implant breast reconstruction, the authors report the first experience in the literature using an absorbable mesh as an inferolateral sling. AB - METHODS: A retrospective review was performed of the first 50 consecutive patients (76 reconstructions) who underwent implant-based breast reconstruction with Vicryl mesh from August of 2011 until June of 2012. AB - RESULTS: Fifty patients underwent 76 direct-to-implant reconstructions with Vicryl mesh between August of 2011 and June of 2012 (mean follow-up, 1.2 years). Five breasts (6.6 percent) had complications, with only one complication resulting in implant loss (1.3 percent). Implant positioning and contour were excellent, with only two patients [three breasts (3.9 percent)] undergoing revision procedures, for size enlargement. Using costs available at the authors' institution, use of Vicryl mesh instead of acellular dermal matrix resulted in a direct material cost savings of $172,112 in 10 months. AB - CONCLUSIONS: Results to date have been encouraging, with a low complication rate (6.6 percent) and excellent aesthetic results. The technique has resulted in $172,112 in direct material cost savings over 10 months. Continued follow-up is planned to evaluate long-term results. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 0 (Biocompatible Materials) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000437253.55457.63 PT - Journal Article ID - 10.1097/01.prs.0000437253.55457.63 [doi] ID - 00006534-201402000-00003 [pii] PP - ppublish LG - English DP - 2014 Feb EZ - 2014/01/29 06:00 DA - 2014/03/25 06:00 DT - 2014/01/29 06:00 YR - 2014 ED - 20140324 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24469217 <255. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24469157 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Moyer HR AU - Pinell-White X AU - Losken A FA - Moyer, Hunter R FA - Pinell-White, Ximena FA - Losken, Albert IN - Moyer, Hunter R. Atlanta, Ga. From the Division of Plastic and Reconstructive Surgery, Emory University; and Atlanta Plastic Surgery. TI - The effect of radiation on acellular dermal matrix and capsule formation in breast reconstruction: clinical outcomes and histologic analysis. SO - Plastic & Reconstructive Surgery. 133(2):214-21, 2014 Feb AS - Plast Reconstr Surg. 133(2):214-21, 2014 Feb NJ - Plastic and reconstructive surgery VO - 133 IP - 2 PG - 214-21 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/re [Radiation Effects] MH - Adult MH - Female MH - Humans MH - *Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pa [Pathology] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Radiotherapy/ae [Adverse Effects] MH - *Tissue Expansion MH - Treatment Outcome AB - BACKGROUND: The authors compared clinical outcomes to determine whether acellular dermal matrix altered the capsular tissue architecture in irradiated and nonirradiated breasts following matrix-assisted expander reconstruction. AB - METHODS: Part I included all 27 patients who underwent bilateral tissue expander reconstruction with acellular dermal matrix between 2007 and 2012 and subsequent unilateral radiation therapy. Part II included a subset of patients with capsular biopsy specimens taken at the time of implant exchange for histologic analysis. Specimens included irradiated and nonirradiated acellular dermal matrix and irradiated and nonirradiated native capsule. Clinical outcomes were analyzed in relation to capsule architecture and acellular dermal matrix performance. AB - RESULTS: In part I, mean follow-up was 28 months. Grade III/IV contractures were identified in nine patients (all on the irradiated side), and 12 developed noncontracture complications (75 percent on the irradiated side). Nine patients were unable to continue with implant reconstruction and required salvage with autologous tissue. In part II, postirradiation biopsy specimens were taken of the peri-implant capsule in six patients at the time of secondary surgery. Elastin content and the total cellular infiltrate were significantly greater in the irradiated versus nonirradiated native capsules (p = 0.0015). Conversely, the irradiated matrix capsule was composed of similar amounts of cellular infiltrate and collagen as the nonirradiated matrix capsules and nonirradiated native capsules. Irradiated acellular dermal matrix showed the least amount of alpha-smooth actin staining but a similar number of blood vessels. AB - CONCLUSION: Acellular dermal matrix appears to limit the elastosis and chronic inflammation seen in irradiated implant reconstructions and is potentially beneficial in these patients. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000437255.01199.42 PT - Journal Article ID - 10.1097/01.prs.0000437255.01199.42 [doi] ID - 00006534-201402000-00002 [pii] PP - ppublish LG - English DP - 2014 Feb EZ - 2014/01/29 06:00 DA - 2014/03/25 06:00 DT - 2014/01/29 06:00 YR - 2014 ED - 20140324 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24469157 <256. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24374665 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dumanian GA FA - Dumanian, Gregory A IN - Dumanian, Gregory A. Chicago, Ill. From Northwestern Memorial Hospital. TI - Discussion: Applications of acellular dermal matrix in revision breast reconstruction surgery. CM - Comment in: Plast Reconstr Surg. 2014 Aug;134(2):323e; PMID: 25068353 CM - Comment on: Plast Reconstr Surg. 2014 Jan;133(1):1-10; PMID: 24105085 SO - Plastic & Reconstructive Surgery. 133(1):11-3, 2014 Jan AS - Plast Reconstr Surg. 133(1):11-3, 2014 Jan NJ - Plastic and reconstructive surgery VO - 133 IP - 1 PG - 11-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/ae [Adverse Effects] MH - *Postoperative Complications/su [Surgery] MH - *Reoperation/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000437226.85058.10 PT - Comment PT - Journal Article ID - 10.1097/01.prs.0000437226.85058.10 [doi] ID - 00006534-201401000-00002 [pii] PP - ppublish LG - English DP - 2014 Jan EZ - 2014/01/01 06:00 DA - 2014/03/04 06:00 DT - 2013/12/31 06:00 YR - 2014 ED - 20140303 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24374665 <257. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24105085 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL AU - Sher SR AU - Al-Attar A AU - Pittman T FA - Spear, Scott L FA - Sher, Sarah R FA - Al-Attar, Ali FA - Pittman, Troy IN - Spear, Scott L. Washington, D.C. From the Department of Plastic Surgery, Georgetown University Hospital. TI - Applications of acellular dermal matrix in revision breast reconstruction surgery. CM - Comment in: Plast Reconstr Surg. 2014 Jan;133(1):11-3; PMID: 24374665 CM - Comment in: Plast Reconstr Surg. 2014 Aug;134(2):323e; PMID: 25068353 SO - Plastic & Reconstructive Surgery. 133(1):1-10, 2014 Jan AS - Plast Reconstr Surg. 133(1):1-10, 2014 Jan NJ - Plastic and reconstructive surgery VO - 133 IP - 1 PG - 1-10 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adolescent MH - Adult MH - Aged MH - Breast/su [Surgery] MH - Breast Implants/ae [Adverse Effects] MH - Female MH - Follow-Up Studies MH - Humans MH - Implant Capsular Contracture MH - *Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/ae [Adverse Effects] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - *Postoperative Complications/su [Surgery] MH - *Reoperation/mt [Methods] MH - Surgical Flaps MH - Thoracic Wall/su [Surgery] MH - Young Adult AB - BACKGROUND: Acellular dermal matrix has been used for over a decade in primary breast reconstruction. Few articles have specifically examined its use in revision breast reconstruction for fold malposition, capsular contracture, rippling, and symmastia. AB - METHODS: One hundred thirty-five revision breast reconstructive procedures using acellular dermal matrix (AlloDerm) in 118 patients (154 breasts) over a 5-year period were reviewed. Most procedures were revisions or part of the second stage of previous mastectomy reconstructions; three were revisions after reconstruction of congenital chest wall deformities. AB - RESULTS: Fifty-seven revisions (37 percent) were for inferior fold malposition, followed by 40 (25.9 percent) for inferior pole support, 42 (27.2 percent) for capsular contracture, 10 (6.4 percent) for rippling, and five (3.2 percent) for symmastia. The overall complication rate was 5 percent. Revisions with acellular dermal matrix were successful in 147 of 154 breasts (95.5 percent). The most common complication was capsular contracture, occurring in five breasts (3.2 percent). There was one infection (0.6 percent), failure to lower the inframammary fold in one breast (0.6 percent), and one persistence of rippling (0.6 percent). The mean follow-up was 207 days. AB - CONCLUSIONS: Acellular dermal matrix has proven to be a reliable tool for managing some of the most common and challenging problems in implant-based breast reconstruction. Although there are few published data on the success of more conventional solutions to fold malposition, lower pole support, and capsular contracture, the addition of acellular dermal matrix to buttress these repairs has been shown to provide a high likelihood of success with a low risk of complications. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000436810.88659.36 PT - Journal Article ID - 10.1097/01.prs.0000436810.88659.36 [doi] PP - ppublish LG - English DP - 2014 Jan EZ - 2013/10/10 06:00 DA - 2014/03/04 06:00 DT - 2013/10/10 06:00 YR - 2014 ED - 20140303 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&AN=24105085 <258. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24378075 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Kornstein A FA - Kornstein, Andrew IN - Kornstein, Andrew. Museum Mile Surgery Center, 1050 Fifth Avenue, New York, NY 10028, USA. andrewkornstein@gmail.com. TI - Porcine-derived acellular dermal matrix in primary augmentation mammoplasty to minimize implant-related complications and achieve an internal mastopexy: a case series. SO - Journal of Medical Case Reports [Electronic Resource]. 7:275, 2013 Dec 30 AS - J Med Case Reports. 7:275, 2013 Dec 30 NJ - Journal of medical case reports VO - 7 PG - 275 PI - Journal available in: Electronic PI - Citation processed from: Print JC - 101293382 IO - J Med Case Rep PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917530 CP - England AB - INTRODUCTION: Patients who present for augmentation mammoplasty with poor quality mammary soft-tissue support may be at increased risk for post-operative complications. Non-crosslinked intact porcine-derived acellular dermal matrix (StratticeTM Reconstructive Tissue Matrix, LifeCell Corp., Branchburg, NJ, USA) may enhance soft-tissue support in such patients and reduce implant-related complications, including capsular contracture, rippling, palpability, and malposition. The objective of this case report series was to describe the outcomes of three patients with poor quality mammary soft-tissue support who underwent primary cosmetic breast augmentation with pre-emptive implantation of porcine-derived acellular dermal matrix. AB - CASE PRESENTATION: Case 1 concerns a 40-year-old Caucasian woman with post-partum soft tissue laxity and grade II ptosis. Case 2 concerns a 30-year-old Caucasian woman with congenital soft-tissue laxity and grade I+ptosis. Case 3 concerns a 49-year-old Caucasian woman with post-partum and post-weight-loss-induced laxity and grade III ptosis. In all three of our patients, porcine-derived acellular dermal matrix was sutured to the chest wall along the infra-mammary and/or a neo-infra-mammary fold and then laid passively superiorly or sutured under tension to the breast parenchyma or caudal edge of the pectoralis major muscle. In cases 1 and 2, a modified internal mastopexy technique was performed. Suturing the porcine-derived acellular dermal matrix to the posterior aspect of the breast parenchyma and/or caudal pectoralis muscle under appropriate tension in conjunction with radial plication of the porcine-derived acellular dermal matrix created a snug 'hand-in-glove' pocket and resulted in only minimal peri-areolar scarring. Case 3 required a vertical scar mastopexy. During a mean of 18 months of follow-up, all three patients had positive outcomes and no complications (that is, infection, hematoma, seroma, rippling, malposition, or capsular contracture). The surgeon and patients were generally highly satisfied with the aesthetic outcome of the breasts. AB - CONCLUSIONS: Pre-emptive use of porcine-derived acellular dermal matrix may be beneficial in patients with primary augmentation with poor quality mammary soft-tissue support. IS - 1752-1947 IL - 1752-1947 DO - https://dx.doi.org/10.1186/1752-1947-7-275 PT - Journal Article ID - 1752-1947-7-275 [pii] ID - 10.1186/1752-1947-7-275 [doi] ID - PMC3917530 [pmc] PP - epublish PH - 2013/04/23 [received] PH - 2013/10/15 [accepted] LG - English EP - 20131230 DP - 2013 Dec 30 EZ - 2014/01/01 06:00 DA - 2014/01/01 06:01 DT - 2014/01/01 06:00 YR - 2013 ED - 20140210 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24378075 <259. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24281573 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Handel N FA - Handel, Neal IN - Handel, Neal. Santa Barbara, Calif. From the Division of Plastic Surgery, David Geffen School of Medicine, University of California, Los Angeles. TI - The double-bubble deformity: cause, prevention, and treatment. [Review] CM - Comment in: Plast Reconstr Surg. 2013 Dec;132(6):1444-5; PMID: 24281574 CM - Comment in: Plast Reconstr Surg. 2014 Jul;134(1):161e-162e; PMID: 25028831 SO - Plastic & Reconstructive Surgery. 132(6):1434-43, 2013 Dec AS - Plast Reconstr Surg. 132(6):1434-43, 2013 Dec NJ - Plastic and reconstructive surgery VO - 132 IP - 6 PG - 1434-43 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Breast/ah [Anatomy & Histology] MH - Breast/su [Surgery] MH - *Breast Implantation/ae [Adverse Effects] MH - *Breast Implants MH - Female MH - Humans MH - Middle Aged MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Postoperative Complications/su [Surgery] MH - *Postoperative Complications MH - *Reoperation/mt [Methods] AB - BACKGROUND: The double-bubble deformity is a widely recognized complication of breast augmentation, but there have been very few articles in the peer-reviewed literature devoted exclusively to this topic. AB - METHODS: Prior publications addressing the anatomy of the inframammary fold and its relationship to the double-bubble deformity are systematically reviewed. Disagreements among authorities regarding the precise anatomical structure of the inframammary fold are addressed. The cause and surgical correction of the double-bubble deformity are discussed in detail as they relate to the anatomy of the fold. AB - RESULTS: The key to understanding the causes and correction of the double bubble lies in an appreciation of the anatomy of the inframammary fold. Correction of the deformity varies depending on whether or not patients had preexisting anatomical features predisposing them to development of a double bubble. AB - CONCLUSION: A variety of surgical strategies, including use of a dual-plane pocket, form-stable shaped implants, capsulorrhaphy, pocket plane conversion, and use of acellular dermal matrices can play a role in prevention and treatment of the double-bubble deformity. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/01.prs.0000434405.91316.96 PT - Case Reports PT - Journal Article PT - Review ID - 10.1097/01.prs.0000434405.91316.96 [doi] ID - 00006534-201312000-00011 [pii] PP - ppublish LG - English DP - 2013 Dec EZ - 2013/11/28 06:00 DA - 2014/01/29 06:00 DT - 2013/11/28 06:00 YR - 2013 ED - 20140128 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24281573 <260. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23823832 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Qi Y AU - You WT AU - Li D AU - Li JN FA - Qi, Yue FA - You, Wei-tao FA - Li, Dong FA - Li, Jian-ning IN - Qi, Yue. Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100041, China. TI - Application of acellular dermal matrix in breast reconstruction. [Review] SO - Chinese Medical Journal. 126(13):2548-52, 2013 Jul AS - Chin Med J. 126(13):2548-52, 2013 Jul NJ - Chinese medical journal VO - 126 IP - 13 PG - 2548-52 PI - Journal available in: Print PI - Citation processed from: Internet JC - 0005256, d3b, 7513795 IO - Chin. Med. J. SB - Index Medicus CP - China MH - *Acellular Dermis MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Nipples/su [Surgery] IS - 0366-6999 IL - 0366-6999 PT - Journal Article PT - Review PP - ppublish LG - English DP - 2013 Jul EZ - 2013/07/05 06:00 DA - 2014/01/24 06:00 DT - 2013/07/05 06:00 YR - 2013 ED - 20140123 RD - 20130704 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23823832 <261. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24454465 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Khavanin N AU - Jordan S AU - Lovecchio F AU - Fine NA AU - Kim J FA - Khavanin, Nima FA - Jordan, Sumanas FA - Lovecchio, Francis FA - Fine, Neil A FA - Kim, John IN - Khavanin, Nima. Northwestern University Feinberg School of Medicine, Chicago, USA. IN - Jordan, Sumanas. Northwestern University Feinberg School of Medicine, Chicago, USA. IN - Lovecchio, Francis. Northwestern University Feinberg School of Medicine, Chicago, USA. IN - Fine, Neil A. Northwestern University Feinberg School of Medicine, Chicago, USA. IN - Kim, John. Northwestern University Feinberg School of Medicine, Chicago, USA. TI - Synergistic interactions with a high intraoperative expander fill volume increase the risk for mastectomy flap necrosis. SO - Journal of Breast Cancer. 16(4):426-31, 2013 Dec AS - J. Breast Cancer. 16(4):426-31, 2013 Dec NJ - Journal of breast cancer VO - 16 IP - 4 PG - 426-31 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101314183 IO - J Breast Cancer PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893345 CP - Korea (South) KW - Complications; Mammaplasty; Mastectomy; Necrosis; Tissue expansion devices AB - PURPOSE: Prosthetic-based breast reconstruction is performed with increasing frequency in the United States. Major mastectomy skin flap necrosis is a significant complication with outcomes ranging from poor aesthetic appearance to reconstructive failure. The present study aimed to explore the interactions between intraoperative fill and other risk factors on the incidence of flap necrosis in patients undergoing mastectomy with immediate expander/implant-based reconstruction. AB - METHODS: A retrospective review of 966 consecutive patients (1,409 breasts) who underwent skin or nipple sparing mastectomy with immediate tissue expander reconstruction at a single institution was conducted. Age, body mass index, hypertension, smoking status, premastectomy and postmastectomy radiation, acellular dermal matrix use, and application of the tumescent mastectomy technique were analyzed as potential predictors of flap necrosis both independently and as synergistic variables with high intraoperative fill. The following three measures of interaction were calculated: relative excess risk due to interaction, attributable proportion of risk due to interaction, and synergy index (SI). AB - RESULTS: Intraoperative tissue expander fill volume was high (>=66.7% of the maximum volume) in 40.9% (576 of 1,409 breasts) of cases. The unadjusted flap necrosis rate was greater in the high intraoperative fill cohort than in the low fill cohort (10.4% vs. 7.1%, p=0.027). Multivariate logistic regression did not identify high intraoperative fill volume as an independent risk factor for flap necrosis (odds ratio 1.442, 95% confidence interval 0.973-2.137, p=0.068). However, four risk factors were identified that interacted significantly with intraoperative fill volume, namely tumescence, age, hypertension, and obesity. The SI, or the departure from additive risks, was largest for tumescence (SI, 25.3), followed by hypertension (SI, 2.39), obesity (SI, 2.28), and age older than 50 years (SI, 1.17). AB - CONCLUSION: In the postmastectomy, hypovascular milieu, multiple risk factors decreasing flap perfusion interact with high intraoperative fill volume to cross a threshold and synergistically increase the risk of flap necrosis. IS - 1738-6756 IL - 1738-6756 DO - https://dx.doi.org/10.4048/jbc.2013.16.4.426 PT - Journal Article ID - 10.4048/jbc.2013.16.4.426 [doi] ID - PMC3893345 [pmc] PP - ppublish PH - 2013/08/21 [received] PH - 2013/10/27 [accepted] LG - English EP - 20131231 DP - 2013 Dec EZ - 2014/01/24 06:00 DA - 2014/01/24 06:01 DT - 2014/01/24 06:00 YR - 2013 ED - 20140123 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24454465 <262. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24165587 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ibrahim AM AU - Shuster M AU - Koolen PG AU - Kim K AU - Taghinia AH AU - Sinno HH AU - Lee BT AU - Lin SJ FA - Ibrahim, Ahmed M S FA - Shuster, Marina FA - Koolen, Pieter G L FA - Kim, Kuylhee FA - Taghinia, Amir H FA - Sinno, Hani H FA - Lee, Bernard T FA - Lin, Samuel J IN - Ibrahim, Ahmed M S. Boston, Mass. From the Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School. TI - Analysis of the National Surgical Quality Improvement Program database in 19,100 patients undergoing implant-based breast reconstruction: complication rates with acellular dermal matrix. SO - Plastic & Reconstructive Surgery. 132(5):1057-66, 2013 Nov AS - Plast Reconstr Surg. 132(5):1057-66, 2013 Nov NJ - Plastic and reconstructive surgery VO - 132 IP - 5 PG - 1057-66 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - Adult MH - Biocompatible Materials/ae [Adverse Effects] MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implants/ae [Adverse Effects] MH - *Breast Neoplasms/su [Surgery] MH - Databases, Factual MH - Female MH - Humans MH - Male MH - Middle Aged MH - Quality Improvement MH - Retrospective Studies MH - Tissue Expansion AB - BACKGROUND: The use of acellular dermal matrices has become increasingly popular in immediate and delayed tissue expander/implant-based breast reconstruction. However, it is unclear whether their use is associated with increased postoperative complication rates. Using the American College of Surgeons National Surgical Quality Improvement Program database, the authors assessed baseline differences in demographics and comorbidities with and without acellular dermal matrix and determined whether postoperative complication rates varied. AB - METHODS: Using the national surgical database (2005 to 2011), tissue expander/implant-based breast reconstruction cases were extracted using Current Procedural Terminology codes. Differences in preoperative demographics and comorbidities were assessed using chi-square and t test analysis using SPSS. The authors analyzed variations in complication rates and determined whether demographics and comorbidities affected outcomes using multivariate logistical analysis. A post hoc power study was calculated. AB - RESULTS: Of 19,100 cases, 3301 involved acellular dermal matrix use. Overall complication rates were not statistically significant (acellular dermal matrix, 5.3 percent; non-acellular dermal matrix, 4.9 percent; p=0.396). Several risk factors were statistically significant associated factors of complications. Higher body mass index was associated with wound complications in both cohorts. In the non-acellular dermal matrix group, body mass index, smoking, and diabetes were associated with major complications, and radiotherapy and steroid use with minor complications. AB - CONCLUSIONS: Acellular dermal matrix use did not appear to increase complication rates in tissue expander/implant-based breast reconstruction in this survey of a national surgical database. There was no significant difference in complication rates between the acellular dermal matrix and non-acellular dermal matrix groups. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Biocompatible Materials) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182a3beec PT - Journal Article ID - 10.1097/PRS.0b013e3182a3beec [doi] ID - 00006534-201311000-00004 [pii] PP - ppublish LG - English DP - 2013 Nov EZ - 2013/10/30 06:00 DA - 2014/01/17 06:00 DT - 2013/10/30 06:00 YR - 2013 ED - 20140116 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24165587 <263. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23429218 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Seth AK AU - Persing S AU - Connor CM AU - Davila A AU - Hirsch E AU - Fine NA AU - Kim JY FA - Seth, Akhil K FA - Persing, Scott FA - Connor, Caitlin M FA - Davila, Armando FA - Hirsch, Elliot FA - Fine, Neil A FA - Kim, John Y S IN - Seth, Akhil K. Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. TI - A comparative analysis of cryopreserved versus prehydrated human acellular dermal matrices in tissue expander breast reconstruction. SO - Annals of Plastic Surgery. 70(6):632-5, 2013 Jun AS - Ann Plast Surg. 70(6):632-5, 2013 Jun NJ - Annals of plastic surgery VO - 70 IP - 6 PG - 632-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - *Collagen MH - *Cryopreservation MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - Regression Analysis MH - Retrospective Studies MH - Risk Factors MH - *Specimen Handling/mt [Methods] MH - *Tissue Expansion AB - BACKGROUND: The use of human acellular dermal matrices (HADMs) in breast reconstruction has become routine practice for many reconstructive surgeons. Comparative studies between 2 more common iterations of human acellular dermis are scarce. Our study evaluated reconstructive outcomes of cryopreserved and prehydrated HADMs in comparative fashion. AB - METHODS: This study is a retrospective review of 369 consecutive tissue expander breast reconstructions performed by 2 board-certified plastic surgeons whose practice focuses on breast reconstruction. Data were collected independently by 2 reviewers, and a comparative analysis for statistical significance of outcomes was performed using the Fisher exact test, 2-tailed independent t tests, and regression analysis where appropriate. AB - RESULTS: Over a 5-year period, 255 patients (369 breasts) underwent breast reconstruction utilizing either cryopreserved or prehydrated HADM. Of the total, 136 breasts received cryopreserved and 233 breasts received prehydrated HADMs. The total complication rates for cryopreserved and prehydrated HADMs were 19.1% and 19.3% (P = 1.0), respectively. Additional complication rates were calculated for flap necrosis (8.1% vs 9.0%, P = 0.849), infection requiring intravenous antibiotics (10.3% vs 5.2%, P = 0.09), hematoma (2.9% vs 1.3%, P = 0.431), seroma (2.2% vs 1.0%, P = 1.0), expander exposure/dehiscence (5.9% vs 6.4%, P = 1.0), and number of breasts requiring autologous reconstruction after a complication (4.4% vs 6.4%, P = 0.491). On regression analysis, HADM type was not an independent risk factor for any complication subtype. AB - CONCLUSIONS: The results of this study suggest that there are no significant differences in complication rates between cryopreserved and prehydrated HADMs. RN - 0 (Alloderm) RN - 0 (FlexHD) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e318250f0b4 PT - Comparative Study PT - Evaluation Studies PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/SAP.0b013e318250f0b4 [doi] PP - ppublish LG - English DP - 2013 Jun EZ - 2013/02/23 06:00 DA - 2014/01/17 06:00 DT - 2013/02/23 06:00 YR - 2013 ED - 20140116 RD - 20130514 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23429218 <264. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23407245 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ibrahim AM AU - Ayeni OA AU - Hughes KB AU - Lee BT AU - Slavin SA AU - Lin SJ FA - Ibrahim, Ahmed M S FA - Ayeni, Olubimpe A FA - Hughes, Kenneth B FA - Lee, Bernard T FA - Slavin, Sumner A FA - Lin, Samuel J IN - Ibrahim, Ahmed M S. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. TI - Acellular dermal matrices in breast surgery: a comprehensive review. [Review] SO - Annals of Plastic Surgery. 70(6):732-8, 2013 Jun AS - Ann Plast Surg. 70(6):732-8, 2013 Jun NJ - Annals of plastic surgery VO - 70 IP - 6 PG - 732-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Biomechanical Phenomena MH - Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Reoperation MH - Tensile Strength MH - Weight-Bearing AB - INTRODUCTION: Acellular dermal matrices (ADMs) have become increasingly popular for use in plastic surgery. There has been an increase in the number of products that have paralleled their usage in various clinical settings and specifically breast surgery. AB - METHODS: A direct comparison of the most common ADMs used in breast surgery was performed including physical characteristics, level of sterility, maximum load sustained (N), stiffness (N/mm), and tensile strength (N/cm). A comprehensive review of the literature was also performed, detailing known results and complications. AB - RESULTS: The direct comparison of most common ADMs is detailed along with a review of 26 series of breast reconstruction manuscripts involving the usage of ADMs. Specifically, Strattice and Permacol had the highest values of maximum loads sustained, stiffness, and tensile strength. AB - CONCLUSIONS: ADMs have a role in breast surgery that continues to be defined. Future long-term follow-up remains crucial to the identification of the optimal biologic mesh. RN - 0 (Alloderm) RN - 0 (FlexHD) RN - 0 (Permacol) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31824b3d30 PT - Comparative Study PT - Journal Article PT - Review ID - 10.1097/SAP.0b013e31824b3d30 [doi] PP - ppublish LG - English DP - 2013 Jun EZ - 2013/02/15 06:00 DA - 2014/01/17 06:00 DT - 2013/02/15 06:00 YR - 2013 ED - 20140116 RD - 20130514 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23407245 <265. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24367186 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Borgognone A AU - Anniboletti T AU - De Vita F FA - Borgognone, Alessandro FA - Anniboletti, Tommaso FA - De Vita, Francesco IN - Borgognone, Alessandro. Department of Plastic and Reconstructive Surgery, CTO Hospital, Rome, Italy. IN - Anniboletti, Tommaso. Department of Plastic and Reconstructive Surgery, CTO Hospital, Rome, Italy. IN - De Vita, Francesco. Department of Plastic and Reconstructive Surgery, CTO Hospital, Rome, Italy. TI - Does Veritas play a role in breast reconstruction? a case report. SO - Breast Cancer Targets and Therap. 3:175-7, 2011 AS - Breast Cancer (Dove Med Press). 3:175-7, 2011 NJ - Breast cancer (Dove Medical Press) VO - 3 PG - 175-7 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101591856 IO - Breast Cancer (Dove Med Press) PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846867 CP - New Zealand KW - Veritas; bovine collagen; breast reconstruction; implant-based; patch AB - To reduce operative times and surgical complications in implant-based breast reconstruction, many authors advocate the use of exogenous material (modified xenograft) to support tissue regeneration. In this article, a case is presented in which a bovine collagen patch (Veritas Collagen Matrix; Synovis Surgical Innovations, St Paul, MN) was used in the immediate breast reconstruction with an implant. The good results obtained in this case confirm Veritas as a viable alternative to AlloDerm Regenerative Tissue Matrix (LifeCell Corporation, Branchburg, NJ) and further support its ability to sustain and stimulate recovery of the surrounding tissues. IS - 1179-1314 IL - 1179-1314 DO - https://dx.doi.org/10.2147/BCTT.S27954 PT - Journal Article ID - 10.2147/BCTT.S27954 [doi] ID - bctt-3-175 [pii] ID - PMC3846867 [pmc] PP - epublish LG - English EP - 20111220 DP - 2011 EZ - 2011/01/01 00:00 DA - 2011/01/01 00:01 DT - 2013/12/25 06:00 YR - 2011 ED - 20131224 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24367186 <266. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23871569 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lynch MP AU - Chung MT AU - Rinker BD FA - Lynch, Michael P FA - Chung, Michael T FA - Rinker, Brian D IN - Lynch, Michael P. University of Kentucky, Department of Surgery, Division of Plastic and Reconstructive Surgery, Lexington, KY, USA. Electronic address: michael.lynch@uky.edu. TI - Dermal autografts as a substitute for acellular dermal matrices (ADM) in tissue expander breast reconstruction: a prospective comparative study. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(11):1534-42, 2013 Nov AS - J Plast Reconstr Aesthet Surg. 66(11):1534-42, 2013 Nov NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 11 PG - 1534-42 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Abdomen/su [Surgery] MH - Acellular Dermis/ae [Adverse Effects] MH - *Acellular Dermis MH - Adult MH - Aged MH - Cicatrix/et [Etiology] MH - Female MH - Health Care Costs MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Microvessels MH - Middle Aged MH - Operative Time MH - Patient Satisfaction MH - Prospective Studies MH - Skin/bs [Blood Supply] MH - Skin Transplantation/ae [Adverse Effects] MH - *Skin Transplantation MH - Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion/ec [Economics] MH - *Tissue Expansion/mt [Methods] MH - Transplant Donor Site/su [Surgery] MH - Wound Healing KW - Acellular dermal matrices; AlloDerm(); Breast reconstruction; Dermal autograft; Tissue expander AB - The use of acellular dermal matrix (ADM) in tissue expander breast reconstruction has several advantages but increased complications have been reported. Dermal autografts may offer a safer and more cost-effective alternative. The purpose of this prospective study was to compare the outcomes of tissue expander breast reconstruction using dermal autografts with ADM-assisted reconstruction. Patients undergoing tissue expander breast reconstruction with either ADM or dermal autografts were enrolled. Autografts were harvested from the lower abdomen. At each follow-up visit, patients were surveyed on a seven-point scale for scar and overall satisfaction. Biopsies taken at the time of device exchange were evaluated histologically with CD34 staining to assess tissue integration and vessel ingrowth. Expansion parameters, complications, procedural costs, and operative times were compared. Forty-eight patients were enrolled (76 breasts). Twenty-seven patients received ADM, and twenty-one patients received dermal autograft. Wound healing complications were significantly higher in the ADM group (14.8% versus 4.8%, p-value = 0.03), as were major complications (18.5% versus 0%, p-value < 0.01). Histologic vessel counts in the autograft group averaged 21 vessels/mm(2), compared to 7 vessels/mm(2) in the ADM group (p-value < 0.01). There was no difference between the two groups in scar satisfaction or overall satisfaction. Patients receiving dermal autograft had a lower incidence of major complications and delayed wound healing than patients who received ADM. Despite harvest time, the overall cost of the ADM-assisted expander placement was higher. Dermal autograft-assisted breast reconstruction offers many of the benefits of ADM, but with a lower cost and improved safety profile. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00412-9 DO - https://dx.doi.org/10.1016/j.bjps.2013.07.002 PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S1748-6815(13)00412-9 [pii] ID - 10.1016/j.bjps.2013.07.002 [doi] PP - ppublish PH - 2013/02/19 [received] PH - 2013/05/01 [revised] PH - 2013/07/01 [accepted] LG - English EP - 20130717 DP - 2013 Nov EZ - 2013/07/23 06:00 DA - 2013/12/24 06:00 DT - 2013/07/23 06:00 YR - 2013 ED - 20131223 RD - 20131008 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23871569 <267. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23810606 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tan BK FA - Tan, Benny K H IN - Tan, Benny K H. Banner MD Anderson Cancer Center, Plastic and Reconstructive Surgery, 2940 E Banner Gateway Drive, Gilbert, AZ 85234, United States. Electronic address: bennytanmd@gmail.com. TI - Pie crusting of acellular dermal matrix may help decrease incidence of seromas in breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(11):1629-30, 2013 Nov AS - J Plast Reconstr Aesthet Surg. 66(11):1629-30, 2013 Nov NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 11 PG - 1629-30 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Humans MH - Seroma/et [Etiology] MH - *Seroma/pc [Prevention & Control] ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00350-1 DO - https://dx.doi.org/10.1016/j.bjps.2013.06.013 PT - Letter ID - S1748-6815(13)00350-1 [pii] ID - 10.1016/j.bjps.2013.06.013 [doi] PP - ppublish PH - 2013/05/15 [received] PH - 2013/06/02 [accepted] LG - English EP - 20130627 DP - 2013 Nov EZ - 2013/07/03 06:00 DA - 2013/12/24 06:00 DT - 2013/07/02 06:00 YR - 2013 ED - 20131223 RD - 20131008 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23810606 <268. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23751974 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Veneroso A AU - Gianquinto D AU - Trapasso M AU - Falco E FA - Veneroso, A FA - Gianquinto, D FA - Trapasso, M FA - Falco, E IN - Veneroso, A. Department of Surgery, S.Andrea Hospital of La Spezia, 19100 La Spezia, Italy. TI - Breast reconstruction using implant and acellular dermal matrix: "the trapezoidal technique". SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(11):e332-3, 2013 Nov AS - J Plast Reconstr Aesthet Surg. 66(11):e332-3, 2013 Nov NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 11 PG - e332-3 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - *Breast Implants MH - Humans MH - *Mammaplasty/mt [Methods] ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00308-2 DO - https://dx.doi.org/10.1016/j.bjps.2013.05.033 PT - Letter ID - S1748-6815(13)00308-2 [pii] ID - 10.1016/j.bjps.2013.05.033 [doi] PP - ppublish PH - 2013/04/22 [received] PH - 2013/05/14 [accepted] LG - English EP - 20130607 DP - 2013 Nov EZ - 2013/06/12 06:00 DA - 2013/12/24 06:00 DT - 2013/06/12 06:00 YR - 2013 ED - 20131223 RD - 20131008 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23751974 <269. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24128977 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Thiruchelvam PT AU - McNeill F AU - Jallali N AU - Harris P AU - Hogben K FA - Thiruchelvam, Paul T R FA - McNeill, Fiona FA - Jallali, Navid FA - Harris, Paul FA - Hogben, Katy IN - Thiruchelvam, Paul T R. Imperial College NHS Trust, Charing Cross Hospital, London W6 8RF, UK. TI - Post-mastectomy breast reconstruction. [Review][Erratum appears in BMJ. 2013;347:f6810] SO - BMJ. 347:f5903, 2013 Oct 15 AS - BMJ. 347:f5903, 2013 Oct 15 NJ - BMJ (Clinical research ed.) VO - 347 PG - f5903 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 8900488, bmj, 101090866 IO - BMJ SB - Core Clinical Journals (AIM) SB - Index Medicus CP - England MH - Acellular Dermis MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Breast Neoplasms/th [Therapy] MH - Chemotherapy, Adjuvant MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/ae [Adverse Effects] MH - Mastectomy/px [Psychology] MH - *Mastectomy MH - Radiotherapy, Adjuvant MH - Surgical Flaps MH - Time Factors ES - 1756-1833 IL - 0959-535X DI - bmj.f5903 DO - https://dx.doi.org/10.1136/bmj.f5903 PT - Journal Article PT - Review PP - epublish LG - English EP - 20131015 DP - 2013 Oct 15 EZ - 2013/10/17 06:00 DA - 2013/12/18 06:00 DT - 2013/10/17 06:00 YR - 2013 ED - 20131217 RD - 20131219 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24128977 <270. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23790562 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wu C AU - Cipriano J AU - Osgood G Jr AU - Tepper D AU - Siddiqui A FA - Wu, Chaowen FA - Cipriano, Joseph FA - Osgood, Geoffery Jr FA - Tepper, Donna FA - Siddiqui, Aamir IN - Wu, Chaowen. Wayne State University School of Medicine, Detroit, MI, USA. TI - Human acellular dermal matrix (AlloDerm) dimensional changes and stretching in tissue expander/implant breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(10):1376-81, 2013 Oct AS - J Plast Reconstr Aesthet Surg. 66(10):1376-81, 2013 Oct NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 10 PG - 1376-81 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Adult MH - *Breast Implants MH - *Collagen/tu [Therapeutic Use] MH - Elasticity MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Patient Satisfaction MH - Postoperative Complications MH - Prospective Studies MH - Quality of Life MH - Surveys and Questionnaires MH - *Tissue Expansion Devices MH - Treatment Outcome KW - AlloDerm; Breast reconstruction; Human acellular dermal matrix; Tissue expansion AB - BACKGROUND: Human acellular dermal matrix (HADM) is widely used for post-mastectomy tissue expander/implant breast reconstruction. Since HADM has been shown to stretch following placement in other surgical settings, we hypothesised that stretching would occur in breast reconstruction as well. The goal of the study was to quantify the in situ stretch properties of HADM over time in patients undergoing this procedure. AB - METHODS: This was an open-label, prospective case series in adult women who underwent post-mastectomy tissue expander/implant breast reconstruction using HADM. HADM construct size was determined at postoperative day 1 and month 3 via ultrasound tracking of metallic 3-mm vessel clips embedded in the graft. Dimensional changes were further examined in four equally sized segments (medial, lateral and two central) of the matrix. Patient satisfaction was evaluated at month 3 (a modified version of the Breast QTM patient questionnaire) and compared with satisfaction reported by a non-HADM reconstruction cohort. AB - RESULTS: A total of 31 patients underwent breast reconstruction with HADM. Mean (standard deviation) perimeter increased from 38 (6) cm on postoperative day 1-42 (7) cm at month 3 (+11%; P=0.002). Surface area increased from 73 (22) to 88 (28) cm2 (+21%; range, 4-35%; P=0.002). The greatest expansion occurred in the HADM medial and lateral segments (range, 18-30% across the four segments). Patient satisfaction was comparable with that of non-HADM patients. Complications in the HADM group included late seroma, red breast syndrome and urinary tract infection. Complications in the non-HADM cohort included cellulitis, expander explantation, delayed wound healing and skin necrosis. AB - CONCLUSIONS: During short-term follow-up, HADM exhibited a modest degree of stretching during tissue expander/implant breast reconstruction and was associated with few complications and a high level of patient satisfaction. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00293-3 DO - https://dx.doi.org/10.1016/j.bjps.2013.05.018 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S1748-6815(13)00293-3 [pii] ID - 10.1016/j.bjps.2013.05.018 [doi] PP - ppublish PH - 2012/12/10 [received] PH - 2013/03/20 [revised] PH - 2013/05/05 [accepted] LG - English EP - 20130620 DP - 2013 Oct EZ - 2013/06/25 06:00 DA - 2013/12/16 06:00 DT - 2013/06/25 06:00 YR - 2013 ED - 20131204 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23790562 <271. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23764323 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Schmitz M AU - Bertram M AU - Kneser U AU - Keller AK AU - Horch RE FA - Schmitz, Marweh FA - Bertram, Martin FA - Kneser, Ulrich FA - Keller, Andrea K FA - Horch, Raymund E IN - Schmitz, Marweh. Department of Plastic and Hand Surgery, Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany. marweh.schmitz@uk-erlangen.de TI - Experimental total wrapping of breast implants with acellular dermal matrix: a preventive tool against capsular contracture in breast surgery?. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(10):1382-9, 2013 Oct AS - J Plast Reconstr Aesthet Surg. 66(10):1382-9, 2013 Oct NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 10 PG - 1382-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Animals MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - *Contracture/pa [Pathology] MH - *Contracture/pc [Prevention & Control] MH - Gels MH - Immunohistochemistry MH - *Postoperative Complications/pa [Pathology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Prosthesis Design MH - Random Allocation MH - Rats MH - Rats, Inbred Lew MH - Silicones KW - Acellular dermal matrix; Capsular contracture; Silicone breast implants; Total wrapping of implants AB - BACKGROUND: Capsular contracture remains a hitherto unsolved complication after implantation of silicone gel-filled breast prostheses. Based on clinical and experimental data, the use of an acellular dermal matrix as a sheath around implants may lead to lesser capsular contracture acting as a proposed biological environment mimicking wound bed tissue. The aim of our study was to analyse the tissue reaction after implantation of silicone prosthesis with and without an envelope of acellular dermal matrix. AB - METHODS: Implantation of 60 silicone prostheses in the back of Lewis rats were carried out, randomly paired taking one rat from group A and one from group B. Group A included implants completely enveloped with xenogenic acellular dermis and group B undraped silicone implants. At 3, 6 and 12 weeks postoperatively, the samples were explanted and subjected to histological and immunohistochemical evaluation. AB - RESULTS: A new myofibroblast tissue layer was identified in proximity to the implant in both groups. The thickness of the layer in group A was continuously thinner than in group B regarding the different explantation time points. Implants completely wrapped with acellular dermal matrix showed significantly lesser inflammatory signs at 3 and 12 weeks after implantation compared to controls. Cell proliferation after 12 weeks was significantly decreased in group A. AB - CONCLUSION: The slight myofibroblast layer and reduced rate of inflammation and proliferation in the treatment group show a positive effect of total acellular dermal matrix envelope and hypothesise the decrease of capsular contracture in long-term periods. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (Gels) RN - 0 (Silicones) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00295-7 DO - https://dx.doi.org/10.1016/j.bjps.2013.05.020 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S1748-6815(13)00295-7 [pii] ID - 10.1016/j.bjps.2013.05.020 [doi] PP - ppublish PH - 2013/03/15 [received] PH - 2013/05/05 [accepted] LG - English EP - 20130610 DP - 2013 Oct EZ - 2013/06/15 06:00 DA - 2013/12/16 06:00 DT - 2013/06/15 06:00 YR - 2013 ED - 20131204 RD - 20130906 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23764323 <272. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 24076737 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Koltz PF AU - Frey JD AU - Langstein HN FA - Koltz, Peter F FA - Frey, Jordan D FA - Langstein, Howard N IN - Koltz, Peter F. Division of Plastic Surgery, University of Rochester Medical Center, Rochester, N.Y. TI - The use of human acellular dermal matrix in the first stage of implant-based breast reconstruction simplifies the exchange procedure. SO - Plastic & Reconstructive Surgery. 132(4):691e-692e, 2013 Oct AS - Plast Reconstr Surg. 132(4):691e-692e, 2013 Oct NJ - Plastic and reconstructive surgery VO - 132 IP - 4 PG - 691e-692e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Treatment Outcome ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31829fe3d2 PT - Journal Article ID - 10.1097/PRS.0b013e31829fe3d2 [doi] ID - 00006534-201310000-00087 [pii] PP - ppublish LG - English DP - 2013 Oct EZ - 2013/10/01 06:00 DA - 2013/12/16 06:00 DT - 2013/10/01 06:00 YR - 2013 ED - 20131203 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=24076737 <273. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23783060 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Weichman KE AU - Wilson SC AU - Saadeh PB AU - Hazen A AU - Levine JP AU - Choi M AU - Karp NS FA - Weichman, Katie E FA - Wilson, Stelios C FA - Saadeh, Pierre B FA - Hazen, Alexes FA - Levine, Jamie P FA - Choi, Mihye FA - Karp, Nolan S IN - Weichman, Katie E. New York, N.Y. From the New York University Medical Center, Institute of Reconstructive Plastic Surgery. TI - Sterile "ready-to-use" AlloDerm decreases postoperative infectious complications in patients undergoing immediate implant-based breast reconstruction with acellular dermal matrix. SO - Plastic & Reconstructive Surgery. 132(4):725-36, 2013 Oct AS - Plast Reconstr Surg. 132(4):725-36, 2013 Oct NJ - Plastic and reconstructive surgery VO - 132 IP - 4 PG - 725-36 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Asepsis MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Prospective Studies MH - Risk Factors MH - Sterilization MH - Surgical Wound Infection/ep [Epidemiology] MH - *Surgical Wound Infection/pc [Prevention & Control] MH - Tissue Expansion Devices AB - BACKGROUND: Acellular dermal matrix is a commonly used adjunct in implant-based breast reconstruction. Several investigations have shown increased complications associated with its use. Therefore, the authors' institution placed strict limitations on its use and transitioned to sterile "ready-to-use" acellular dermal matrix. The purpose of this investigation was to compare the infectious complications associated with aseptic versus sterile acellular dermal matrix. AB - METHODS: A prospective study of all patients undergoing immediate implant-based breast reconstruction at a single academic medical center between November of 2010 and October of 2012 was conducted. AlloDerm (Life Cell Corporation, Branchburg, N.J.) was used as the source of acellular dermal matrix. Breasts were divided into three cohorts: total submuscular coverage, aseptic acellular dermal matrix, and sterile, ready-to-use acellular dermal matrix. Breasts were then compared based on demographic information, cancer qualities, and complications. AB - RESULTS: A total of 546 reconstructed breasts met inclusion criteria: 64.3 percent (n = 351) with no acellular dermal matrix, 16.5 percent (n = 90) with aseptic matrix, and 19.2 percent (n = 105) with ready-to-use matrix. When comparing reconstructions with ready-to-use versus aseptic acellular dermal matrix, patients had a decrease in overall infection (8.5 percent versus 20.0 percent; p = 0.0088), major infection (4.7 percent versus 12.2 percent; p = 0.069), and need for explantation (1.9 percent versus 6.6 percent; p = 0.1470). When comparing patients undergoing reconstruction with ready-to-use matrix to total submuscular coverage, patients had similar overall infectious complications (8.5 percent versus 5.7 percent; p = 0.3602). Diabetes mellitus, seroma, mastectomy skin flap necrosis, and aseptic acellular dermal matrix were independent predictors of infectious complications. AB - CONCLUSIONS: Ready-to-use acellular dermal matrix in immediate implant-based breast reconstruction provides a useful adjunct. In addition, it mitigates the risks of infectious complications when compared with aseptic acellular dermal matrix. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31829fe35b PT - Clinical Trial PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e31829fe35b [doi] PP - ppublish LG - English DP - 2013 Oct EZ - 2013/06/21 06:00 DA - 2013/12/16 06:00 DT - 2013/06/21 06:00 YR - 2013 ED - 20131203 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23783060 <274. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23985628 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20007, USA. drnahabedian@aol.com TI - Discussion: Treatment of capsular contracture using complete implant coverage by acellular dermal matrix: a novel technique. CM - Comment on: Plast Reconstr Surg. 2013 Sep;132(3):519-29; PMID: 23985627 SO - Plastic & Reconstructive Surgery. 132(3):530-1, 2013 Sep AS - Plast Reconstr Surg. 132(3):530-1, 2013 Sep NJ - Plastic and reconstructive surgery VO - 132 IP - 3 PG - 530-1 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - *Collagen MH - Female MH - Humans MH - *Implant Capsular Contracture/su [Surgery] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318290f712 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318290f712 [doi] ID - 00006534-201309000-00003 [pii] PP - ppublish LG - English DP - 2013 Sep EZ - 2013/08/30 06:00 DA - 2013/12/16 06:00 DT - 2013/08/30 06:00 YR - 2013 ED - 20131202 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23985628 <275. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23985627 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cheng A AU - Lakhiani C AU - Saint-Cyr M FA - Cheng, Angela FA - Lakhiani, Chrisovalantis FA - Saint-Cyr, Michel IN - Cheng, Angela. University of Texas Southwestern Medical Center, Dallas, Texas, USA. TI - Treatment of capsular contracture using complete implant coverage by acellular dermal matrix: a novel technique. CM - Comment in: Plast Reconstr Surg. 2013 Sep;132(3):530-1; PMID: 23985628 SO - Plastic & Reconstructive Surgery. 132(3):519-29, 2013 Sep AS - Plast Reconstr Surg. 132(3):519-29, 2013 Sep NJ - Plastic and reconstructive surgery VO - 132 IP - 3 PG - 519-29 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - Implant Capsular Contracture/pc [Prevention & Control] MH - *Implant Capsular Contracture/su [Surgery] MH - Mastectomy MH - Middle Aged MH - Retrospective Studies MH - Treatment Outcome AB - BACKGROUND: Capsular contracture is a frequent complication of breast reconstruction that affects 2.8 to 15.9 percent of patients. Use of acellular dermal matrix has been reported for treatment of contracture, with a recurrence rate of 6.3 percent, but this was limited to partial implant coverage only. The authors describe a novel surgical technique using acellular dermal matrix to completely cover the implant anteriorly to treat and prevent capsular contracture. AB - METHODS: Charts were reviewed to identify patients who had received implant insertion with complete acellular dermal matrix coverage performed by a single surgeon. Patient demographic information, history of irradiation or capsular contracture, prior treatment, and postoperative complications were recorded. AB - RESULTS: Eleven patients (16 breasts) were identified. Mean age and body mass index were 52.3 +/- 6.9 years and 23.6 +/- 4.4 kg/m, respectively. Four patients (five breasts) had a history of capsular contracture requiring previous capsulectomy and implant exchange. Ten cases were for correction of new-onset grade III (n = 2) or IV (n = 8) capsular contracture and one was to prevent future capsular contracture. Mean acellular dermal matrix size was 229.8 +/- 46.5 cm (range, 144 to 256 cm). Average follow-up was 9.2 months (range, 2.4 to 18.8 months). One patient (one breast) developed an infection requiring implant removal. No patients experienced recurrent capsular contracture. AB - CONCLUSIONS: Capsular contracture may be treated successfully using complete acellular dermal matrix coverage. This technique may be a useful addition to therapies currently used to treat recalcitrant capsular contracture (early recurrence or refractory to standard therapy). RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31829acc1e PT - Case Reports PT - Evaluation Studies PT - Journal Article PT - Video-Audio Media ID - 10.1097/PRS.0b013e31829acc1e [doi] ID - 00006534-201309000-00002 [pii] PP - ppublish LG - English DP - 2013 Sep EZ - 2013/08/30 06:00 DA - 2013/12/16 06:00 DT - 2013/08/30 06:00 YR - 2013 ED - 20131202 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23985627 <276. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23542856 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Buseman J AU - Wong L AU - Kemper P AU - Hill JL AU - Nimtz J AU - Rinker B AU - Vasconez HC FA - Buseman, Jason FA - Wong, Lesley FA - Kemper, Pamela FA - Hill, Joseph L FA - Nimtz, Jared FA - Rinker, Brian FA - Vasconez, Henry C IN - Buseman, Jason. Division of Plastic Surgery, Department of Surgery, University of Kentucky, Lexington, KY 40536-0284, USA. TI - Comparison of sterile versus nonsterile acellular dermal matrices for breast reconstruction. SO - Annals of Plastic Surgery. 70(5):497-9, 2013 May AS - Ann Plast Surg. 70(5):497-9, 2013 May NJ - Annals of plastic surgery VO - 70 IP - 5 PG - 497-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Asepsis MH - *Breast Implantation/is [Instrumentation] MH - Breast Implantation/mt [Methods] MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Seroma/ep [Epidemiology] MH - *Seroma/et [Etiology] MH - Seroma/pc [Prevention & Control] MH - *Sterilization MH - Tissue Expansion Devices AB - BACKGROUND: Acellular dermal matrix (ADM) has been associated with an increased incidence of complications after implant-based breast reconstruction. Recently, sterile ADM has been introduced in an attempt to minimize these complications. To analyze the impact of this product on patient outcomes, we created a database of patients undergoing implant-based breast reconstruction. AB - METHODS: Patients undergoing implant-based breast reconstruction at the University of Kentucky Medical Center from January 1, 2011, to December 31, 2011 were identified. A database of patient characteristics and outcomes was created. Outcomes investigated included mastectomy flap necrosis, dehiscence, infection, red breast, capsular contracture, hematoma, and seroma. Statistical analysis was performed. AB - RESULTS: Fifty-eight patients underwent breast reconstruction with implants or tissue expanders. Of the 58 patients, 9 had the sterile form of ADM placed, 25 had the original aseptic but not sterile ADM, and 24 were not reconstructed with ADM. The most frequent complication noted was seroma, occurring in 6/9 patients with sterile ADM as compared to 2/25 with the aseptic ADM. This was statistically significant (P = 0.003). AB - CONCLUSIONS: The use of sterile ADM is associated with a statistically significant increase in seroma formation. The etiology of this increased incidence remains unknown, but it correlates with the introduction of the sterile form of ADM at our institution. A different preparation or sterilization process, or some other variable as yet unknown, may be responsible. Further studies comparing the different forms of ADM in an animal model may serve to clarify this issue. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31827f52c8 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e31827f52c8 [doi] PP - ppublish LG - English DP - 2013 May EZ - 2013/04/02 06:00 DA - 2013/10/26 06:00 DT - 2013/04/02 06:00 YR - 2013 ED - 20131025 RD - 20130412 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23542856 <277. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23542851 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Pestana IA AU - Campbell DC AU - Bharti G AU - Thompson JT FA - Pestana, Ivo A FA - Campbell, Douglas C FA - Bharti, Gaurav FA - Thompson, James T IN - Pestana, Ivo A. From the Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, 27157-1075, USA. TI - Factors affecting complications in radiated breast reconstruction. SO - Annals of Plastic Surgery. 70(5):542-5, 2013 May AS - Ann Plast Surg. 70(5):542-5, 2013 May NJ - Annals of plastic surgery VO - 70 IP - 5 PG - 542-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis/ae [Adverse Effects] MH - Breast Implants/ae [Adverse Effects] MH - *Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Collagen/ae [Adverse Effects] MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/is [Instrumentation] MH - Mammaplasty/mt [Methods] MH - *Mammaplasty MH - *Mastectomy MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Radiotherapy, Adjuvant MH - Reoperation MH - Retrospective Studies MH - Risk Factors MH - Treatment Outcome AB - INTRODUCTION: Breast irradiation in combination with breast reconstruction is associated with increased complications. Because of the diminishing threshold for radiotherapy, breast reconstruction irradiation is rising. Our aim was to evaluate factors affecting outcomes in irradiated breast reconstructions. AB - METHODS: A review of consecutive patients who underwent mastectomy, radiation, and breast reconstruction was conducted. Patient demographics, operative procedure, breast irradiation timing, and postoperative complications were collected. AB - RESULTS: One hundred fifty-four patients (157 breast reconstructions) were included with a mean follow-up of 6 years. Average age at reconstruction was 50 years. One hundred nine cases were immediate and 48 cases were delayed. Sixty-eight cases were autologous reconstructions and 89 cases were implant-based. Thirty-seven cases used acellular dermal matrices (ADMs); 60% of cases were radiated before reconstruction and 40% were radiated afterward. Major complications occurred in 43% of patients and minor complications occurred in 17%. The presence of ADM led to an increase in complication rate with a 2.3-fold greater chance of requiring reoperation (P = 0.03). No significant difference in complication rates was associated with presence of hypertension, diabetes, smoking, elevated body mass index, autologous versus implant-based reconstructions, delayed versus immediate reconstructions, and time between radiation and reconstruction. AB - CONCLUSIONS: Radiation after prosthetic reconstruction may produce an increase in failure rates. The use of ADMs in the face of breast irradiation increases the likelihood of a complication requiring reoperation. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31827eacff PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e31827eacff [doi] PP - ppublish LG - English DP - 2013 May EZ - 2013/04/02 06:00 DA - 2013/10/26 06:00 DT - 2013/04/02 06:00 YR - 2013 ED - 20131025 RD - 20130412 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23542851 <278. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23542848 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Brzezienski MA AU - Jarrell JA 4th AU - Mooty RC FA - Brzezienski, Mark A FA - Jarrell, John A 4th FA - Mooty, Robert Clark IN - Brzezienski, Mark A. From the Department of Plastic Surgery, University of Tennessee College of Medicine Chattanooga, Chattanooga, TN 37403, USA. TI - Classification and management of seromas in immediate breast reconstruction using the tissue expander and acellular dermal matrix technique. SO - Annals of Plastic Surgery. 70(5):488-92, 2013 May AS - Ann Plast Surg. 70(5):488-92, 2013 May NJ - Annals of plastic surgery VO - 70 IP - 5 PG - 488-92 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/is [Instrumentation] MH - Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Drainage/mt [Methods] MH - Drainage/sn [Statistics & Numerical Data] MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - Middle Aged MH - Postoperative Complications/cl [Classification] MH - Postoperative Complications/di [Diagnosis] MH - Postoperative Complications/th [Therapy] MH - *Postoperative Complications MH - Retrospective Studies MH - Seroma/cl [Classification] MH - Seroma/di [Diagnosis] MH - *Seroma/et [Etiology] MH - Seroma/th [Therapy] MH - *Tissue Expansion Devices MH - Treatment Outcome AB - Tissue expander (TE)/acellular dermal matrix (ADM)-based breast reconstruction used in immediate postmastectomy breast reconstruction, although a popular technique, is not without complications.Although seroma formation is recognized and reported in the literature as a complication, little information addresses seroma(s) management. We conducted a retrospective review of 100 consecutive TE/ADM immediate reconstructions during a 2-year period, performed by a single surgeon. Data collection included patient demographics, adjuvant therapy, initial TE fill volume, time to completion of expansion, seroma formation, management of seroma, and wound complications, up to the time of definitive implant exchange. From December 2009 to December 2011, 67 patients (100 reconstructions) underwent TE/ADM immediate breast reconstruction. Thirty-one reconstructions were identified having clinically significant seroma(s). Eighteen of the reconstructions required multiple drainage procedures. With these data, a 3-group classification system was created based on the number of aspirations. In review of the 3 groups, 71% of group III required either Seroma-Cath or operative drainage beyond simple aspiration(s). Of the 100 reconstructions, 3 (3%) ended in TE explantation. Only 1 (3%) TE explantation, interestingly from group I, was attributable to seroma formation. Using the data, we devised a management strategy emphasizing attentiveness to seroma formation, recognition, and treatment. Seroma formation is a known entity linked to complications in TE/ADM reconstructive course. A seroma classification system and treatment algorithm is offered to minimize abandonment of the reconstruction and optimize outcomes. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31827eac93 PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e31827eac93 [doi] PP - ppublish LG - English DP - 2013 May EZ - 2013/04/02 06:00 DA - 2013/10/26 06:00 DT - 2013/04/02 06:00 YR - 2013 ED - 20131025 RD - 20130412 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23542848 <279. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23813397 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Pozner JN AU - White JB AU - Newman MI FA - Pozner, Jason N FA - White, Jeremy B FA - Newman, Martin I IN - Pozner, Jason N. Department of Plastic Surgery, Cleveland Clinic Florida, Weston, FL, USA. JeremyWhiteMD@gmail.com TI - Use of porcine acellular dermal matrix in revisionary cosmetic breast augmentation. SO - Aesthetic Surgery Journal. 33(5):681-90, 2013 Jul AS - Aesthet. surg. j.. 33(5):681-90, 2013 Jul NJ - Aesthetic surgery journal VO - 33 IP - 5 PG - 681-90 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Acellular Dermis MH - Adult MH - Aged MH - Animals MH - *Breast Implants/ae [Adverse Effects] MH - Cohort Studies MH - Esthetics MH - Female MH - Graft Survival MH - Humans MH - Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications/di [Diagnosis] MH - Postoperative Complications/su [Surgery] MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Reoperation/mt [Methods] MH - Retrospective Studies MH - Risk Assessment MH - Surgical Flaps MH - Swine MH - Treatment Outcome MH - Young Adult KW - acellular dermal matrix; breast augmentation; breast implant; capsular contracture; malposition; ptosis; revision; rippling AB - BACKGROUND: Aesthetic breast augmentation can be fraught with postoperative complications, particularly capsular contracture (CC), skin surface irregularities, and implant or inframammary fold malposition. Similar complications have been addressed successfully in reconstructive breast surgery with acellular dermal matrix (ADM) products. AB - OBJECTIVE: The authors present their initial experience with porcine ADM (PADM) in aesthetic breast augmentation. AB - METHODS: Retrospective chart review was performed for 93 consecutive patients (179 breasts) who underwent revisionary cosmetic breast augmentation with or without mastopexy between May 2009 and September 2012. Porcine ADM (Strattice; Lifecell Corp, Branchburg, New Jersey) was placed bilaterally in 74 patients and unilaterally in 19 patients. All patients were operated upon by 1 surgeon (J.N.P.). Product use description and complications were recorded, including infection, extrusion, CC, and implant malposition. AB - RESULTS: Average follow-up was 12 months (range, 1-39 months). There were 2 major complications (1.6% of breasts): an infection in 1 breast that required implant explantation approximately 2 weeks postoperatively and an extrusion that required PADM removal. Two additional patients had high-riding implants resulting from folded PADM that required revision; both cases were corrected by excising the folded PADM segment. Seven other patients required office procedures to correct minor imperfections. Two CC recurrences were suspected (1 patient) in the 76 breasts that underwent capsulectomy and PADM placement. AB - CONCLUSIONS: Porcine ADM demonstrated great utility as an adjunct in revisionary cosmetic breast surgery. The product helped to provide good aesthetic outcomes with low complication rates. Prospective, randomized trials may prove helpful in defining the role of PADM further in these challenging cases. ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X13491279 PT - Journal Article ID - 33/5/681 [pii] ID - 10.1177/1090820X13491279 [doi] PP - ppublish LG - English DP - 2013 Jul EZ - 2013/07/03 06:00 DA - 2013/10/24 06:00 DT - 2013/07/02 06:00 YR - 2013 ED - 20131023 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23813397 <280. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23768943 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ohkuma R AU - Buretta KJ AU - Mohan R AU - Rosson GD AU - Rad AN FA - Ohkuma, Rika FA - Buretta, Kate J FA - Mohan, Raja FA - Rosson, Gedge D FA - Rad, Ariel N IN - Ohkuma, Rika. The Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. TI - Initial experience with the use of foetal/neonatal bovine acellular dermal collagen matrix (SurgiMendTM) for tissue-expander breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(9):1195-201, 2013 Sep AS - J Plast Reconstr Aesthet Surg. 66(9):1195-201, 2013 Sep NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 9 PG - 1195-201 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis/ut [Utilization] MH - Adult MH - Animals MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cattle MH - Cohort Studies MH - Confidence Intervals MH - Esthetics MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Humans MH - Logistic Models MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/ae [Adverse Effects] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Odds Ratio MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/su [Surgery] MH - Retrospective Studies MH - Risk Assessment MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - Treatment Outcome MH - Wound Healing/ph [Physiology] KW - ADM; BMI; Bovine acellular dermal matrix; Breast reconstruction; CDC; Centers for Disease Control; ETO; IMF; IRB; Institutional Review Board; SurgiMendTM; TE; acellular dermal matrix; body-mass index; ethylene oxide; inframammary fold; tissue expander AB - BACKGROUND: Acellular dermal matrix (ADM) is commonly used in staged breast reconstruction using tissue expanders (TEs). The literature on human ADM has reported variable outcomes, and there is a paucity of data for xenogenic sources of ADM. The aim of this study is to evaluate the early complications, risk factors and outcomes using SurgiMendTM in staged breast reconstruction. AB - METHODS: An Institutional Review Board (IRB)-approved, retrospective analysis of a single surgeon's experience was performed. From August 2009 to May 2011, 65 patients underwent staged breast reconstruction using 95 sheets of SurgiMendTM. The nominal TE fill volume was 383 +/- 83 cc (range 250-550), mean intra-operative fill volume was 148 +/- 86 cc (range 0-350) and mean final fill volume was 413 +/- 176 cc (range 100-800). The mean clinic follow-up time was 16.9 +/- 8.7 months; mean age was 50.9 +/- 11.7 years; and average body mass index (BMI) was 26.0 +/- 5.5 kg m(-2). Correlation with risk factors and clinical outcomes were analysed. AB - RESULTS: The incidences of postoperative complications were: haematoma 3.2%, seroma 7.5% and re-operation due to infection 2.1%. Age, diabetes mellitus, and hypertension had a significant correlation with an increased overall complication rate. With respect to early complications, such as infection requiring re-operation, diabetes demonstrated a trend with an odds ratio of 11.69. AB - CONCLUSION: This study demonstrates that the use of SurgiMendTM is associated with low early complication rates and is well tolerated in staged breast reconstruction. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(13)00279-9 DO - https://dx.doi.org/10.1016/j.bjps.2013.05.004 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S1748-6815(13)00279-9 [pii] ID - 10.1016/j.bjps.2013.05.004 [doi] PP - ppublish PH - 2012/10/12 [received] PH - 2013/03/18 [revised] PH - 2013/05/01 [accepted] LG - English EP - 20130613 DP - 2013 Sep EZ - 2013/06/19 06:00 DA - 2013/10/18 06:00 DT - 2013/06/18 06:00 YR - 2013 ED - 20131017 RD - 20130731 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23768943 <281. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23439064 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, California 92354, USA. TI - Efficacy of acellular dermal matrices in revisionary aesthetic breast surgery: a 6-year experience. SO - Aesthetic Surgery Journal. 33(3):389-99, 2013 Mar AS - Aesthet. surg. j.. 33(3):389-99, 2013 Mar NJ - Aesthetic surgery journal VO - 33 IP - 3 PG - 389-99 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast/su [Surgery] MH - Breast Implantation/ae [Adverse Effects] MH - *Esthetics MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications/et [Etiology] MH - *Postoperative Complications/su [Surgery] MH - Reoperation MH - Retrospective Studies MH - Skin Transplantation/ae [Adverse Effects] MH - Skin Transplantation/mt [Methods] MH - *Skin Transplantation MH - Suture Techniques MH - Time Factors MH - Treatment Outcome MH - Young Adult AB - BACKGROUND: Augmentation mammaplasty and augmentation mastopexy are associated with a substantial primary and secondary revision rate. Capsular contracture (CC), implant malposition, ptosis, asymmetry, and rippling are the main reasons for revisionary surgery in these patients. Traditional corrective techniques have not been completely reliable in preventing or treating these complications. Recently, acellular dermal matrices (ADM) have been used to assist with revisionary surgery with promising results. AB - OBJECTIVE: The authors review their 6-year experience using ADM for revisionary surgery in aesthetic patients and evaluate long-term outcomes with this approach. AB - METHODS: Patients who underwent revisionary breast augmentation or augmentation mastopexy with ADM in conjunction with standard techniques over a 6-year period between October 2005 and December 2011 were retrospectively reviewed. Only patients with at least 1 year of follow-up were included in the analysis. AB - RESULTS: A total of 197 revisions were performed (197 patients). Reasons for revision included CC (61.8%), implant malposition (31.2%), rippling (4.8%), ptosis (4.8%), implant exposure (1.6%), and breast wound (0.5%). The mean +/- SD follow-up period was 3.1 +/- 1.1 years (range, 0.1-6.1 years). The complication rate was 4.8%, including Baker grade III/IV CC (1.6%), infection (1.6%), implant malposition (0.5%), hematoma (0.5%), and seroma (0.5%). Most (98%) revisions were successful, with no recurrence of the presenting complaint. AB - CONCLUSIONS: The use of ADM in conjunction with standard techniques for the reinforcement of weak tissue in revision augmentation and augmentation mastopexy patients appears to be effective. ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X13478967 PT - Journal Article ID - 1090820X13478967 [pii] ID - 10.1177/1090820X13478967 [doi] PP - ppublish LG - English EP - 20130225 DP - 2013 Mar EZ - 2013/02/27 06:00 DA - 2013/09/26 06:00 DT - 2013/02/27 06:00 YR - 2013 ED - 20130925 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23439064 <282. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23435509 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bogdanov-Berezovsky A AU - Silberstein E AU - Shoham Y AU - Krieger Y FA - Bogdanov-Berezovsky, A FA - Silberstein, E FA - Shoham, Y FA - Krieger, Y IN - Bogdanov-Berezovsky, A. Department of Plastic and Reconstructive Surgery and Burn Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101, Beer-Sheva, Israel. alexb@bgu.ac.il TI - Capsular flap: new applications. SO - Aesthetic Plastic Surgery. 37(2):395-7, 2013 Apr AS - Aesthetic Plast Surg. 37(2):395-7, 2013 Apr NJ - Aesthetic plastic surgery VO - 37 IP - 2 PG - 395-7 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - *Breast Implants/ae [Adverse Effects] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Graft Survival MH - Humans MH - Prosthesis Design MH - Prosthesis Failure MH - Reoperation/mt [Methods] MH - Risk Assessment MH - Silicone Gels/ae [Adverse Effects] MH - *Surgical Flaps MH - Treatment Outcome AB - UNLABELLED: Breast augmentation with silicone implants is one of the most commonly performed procedures for women seeking improvement in their body image. Because the number of breast augmentation operations is growing, the number of subsequent reoperations is increasing. Causes for repeated operative procedures include infection, capsular contracture, silicone implant replacement, and breast reaugmentation. As the average volume of silicone implants used is steadily growing according to patients' wishes and fashion requirements, the plastic surgeon often is asked to replace the silicone implants with larger implants. Replacing breast implants with a similar sized implant is a relatively simple operation, but insertion of larger implants may present a challenge due to insufficient soft tissue coverage of the lower pole of the larger breast implant, especially in thin subjects. Total coverage of the breast implant can be achieved by use of tissue substitutes (TS), such as acellular dermal matrices. Usage of TS, however, is prone to complications and very costly, and these factors influence the implementation of TS in a private practice setup. This report describes a capsular flap used to cover the lower pole of breast implants. The flap guarantees multilayered stable wound closure and prevents displacement of the inframammary fold. The capsular flap also was used to correct an inferiorly displaced inframammary fold as a consequence of the breast augmentation. AB - LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . RN - 0 (Silicone Gels) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-013-0094-4 PT - Case Reports PT - Journal Article ID - 10.1007/s00266-013-0094-4 [doi] PP - ppublish PH - 2012/11/15 [received] PH - 2013/01/31 [accepted] LG - English EP - 20130222 DP - 2013 Apr EZ - 2013/02/26 06:00 DA - 2013/09/21 06:00 DT - 2013/02/26 06:00 YR - 2013 ED - 20130919 RD - 20131106 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23435509 <283. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23806958 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dieterich M AU - Paepke S AU - Zwiefel K AU - Dieterich H AU - Blohmer J AU - Faridi A AU - Klein E AU - Gerber B AU - Nestle-Kraemling C FA - Dieterich, Max FA - Paepke, Stefan FA - Zwiefel, Karin FA - Dieterich, Holger FA - Blohmer, Jens FA - Faridi, Andree FA - Klein, Evelyn FA - Gerber, Bernd FA - Nestle-Kraemling, Carolin IN - Dieterich, Max. Department of Obstetrics and Gynecology, Interdisciplinary Breast Center, University of Rostock, Rostock, Germany. max.dieterich@uni-rostock.de TI - Implant-based breast reconstruction using a titanium-coated polypropylene mesh (TiLOOP Bra): a multicenter study of 231 cases. SO - Plastic & Reconstructive Surgery. 132(1):8e-19e, 2013 Jul AS - Plast Reconstr Surg. 132(1):8e-19e, 2013 Jul NJ - Plastic and reconstructive surgery VO - 132 IP - 1 PG - 8e-19e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Coated Materials, Biocompatible MH - Female MH - Follow-Up Studies MH - Germany/ep [Epidemiology] MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Patient Satisfaction MH - *Polypropylenes MH - Postoperative Complications/ep [Epidemiology] MH - Prognosis MH - Retrospective Studies MH - Risk Factors MH - *Surgical Mesh MH - Time Factors MH - *Titanium MH - Young Adult AB - BACKGROUND: An alternative to implant-based breast reconstruction using acellular dermal matrix is the use of a titanium-coated polypropylene mesh. The mesh was approved for implant-based breast reconstruction in Europe in 2008, but only limited clinical data are available. AB - METHODS: Two hundred seven patients (231 breasts) with skin-sparing/nipple-sparing or modified radical mastectomy and immediate or delayed implant-based breast reconstruction using titanium-coated polypropylene mesh were evaluated retrospectively. The primary endpoints were identification of patient-related and surgical factors that were predictive for an adverse outcome and the development of recommendations for patients eligible for implant-based breast reconstruction using the mesh. Complications were divided into major (need for additional surgery), minor (conservative treatment), and implant loss. Univariate and multivariate logistic regression analyses were performed to determine the influence of the patient- and procedure-related characteristics on postoperative complications and implant loss. AB - RESULTS: No risk factors were observed for patient-associated complications. Major complications occurred in 13.4 percent, minor complications in 15.6 percent, and implant loss in 8.7 percent of patients. Univariate analysis revealed procedure-related risk factors for postoperative complications with a bilateral procedure (p = 0.013) or skin expansion before implant surgery (p = 0.043). Multivariate analysis confirmed these risk factors and revealed an increased risk for implant loss in patients with skin necrosis (p < 0.001) and capsule fibrosis (p < 0.001). AB - CONCLUSIONS: This titanium-coated polypropylene mesh shows acceptable complication rates and can be a helpful device in implant-based breast reconstruction. The mesh should only be used in primary cases and, when adhering to the proposed indications, is a safe and convenient option in implant-based breast reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. RN - 0 (Coated Materials, Biocompatible) RN - 0 (Polypropylenes) RN - D1JT611TNE (Titanium) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318290f8a0 PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial ID - 10.1097/PRS.0b013e318290f8a0 [doi] ID - 00006534-201307000-00006 [pii] PP - ppublish SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT01544023 SL - https://clinicaltrials.gov/search/term=NCT01544023 LG - English DP - 2013 Jul EZ - 2013/06/29 06:00 DA - 2013/09/18 06:00 DT - 2013/06/29 06:00 YR - 2013 ED - 20130917 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23806958 <284. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23806905 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gurunluoglu R FA - Gurunluoglu, Raffi IN - Gurunluoglu, Raffi. Plastic and Reconstructive Surgery, Denver Health Medical Center, Denver, CO 80204, USA. raffi.gurunluoglu@dhha.org TI - Discussion: impact and outcome of human acellular dermal matrix size for immediate and two-stage breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2013 Jul;132(1):11-8; PMID: 23806904 SO - Plastic & Reconstructive Surgery. 132(1):19-21, 2013 Jul AS - Plast Reconstr Surg. 132(1):19-21, 2013 Jul NJ - Plastic and reconstructive surgery VO - 132 IP - 1 PG - 19-21 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/st [Standards] MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Postoperative Complications/pc [Prevention & Control] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318290f6fc PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318290f6fc [doi] ID - 00006534-201307000-00003 [pii] PP - ppublish LG - English DP - 2013 Jul EZ - 2013/06/29 06:00 DA - 2013/09/18 06:00 DT - 2013/06/29 06:00 YR - 2013 ED - 20130917 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23806905 <285. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23806904 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cayci C AU - Santner F AU - Jacobson SR FA - Cayci, Cenk FA - Santner, Florian FA - Jacobson, Steven R IN - Cayci, Cenk. Section of Plastic Surgery, University of Michigan; and the Division of Plastic Surgery, University of Illinois-Chicago, Chicago, IL, USA. TI - Impact and outcome of human acellular dermal matrix size for immediate and two-stage breast reconstruction. CM - Comment in: Plast Reconstr Surg. 2013 Jul;132(1):19-21; PMID: 23806905 SO - Plastic & Reconstructive Surgery. 132(1):11-8, 2013 Jul AS - Plast Reconstr Surg. 132(1):11-8, 2013 Jul NJ - Plastic and reconstructive surgery VO - 132 IP - 1 PG - 11-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/st [Standards] MH - Adult MH - Aged MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Time Factors MH - Tissue Expansion Devices/st [Standards] MH - United States/ep [Epidemiology] AB - BACKGROUND: Following mastectomy, patients may choose to have breast reconstruction with autologous tissue or implants. Human acellular dermal matrix has been described as a tissue supplement where the implant is covered, without requiring further muscle elevation or dissection. The authors evaluated the impact of different matrix sizes. AB - METHODS: Fifty-two patients (average age, 48.5 years) and 88 operated breasts were evaluated. The cohort was divided into two, depending on matrix size. In group A, a small matrix with a surface area of 48 or 96 cm was used. In group B, a larger matrix with either 128 or 160 cm was used. Intraoperative fill volumes, expansion procedure, and complications were analyzed. AB - RESULTS: Size difference was significant (69.2 versus 135.5 cm). The calculated mean initial filling volume-to-excised pathology tissue weight ratio and the initial filling-to-final implant volume ratio were significant. Average number of fills to reach final expansion volume was 62.3 percent, or 4.7 times lower in group B. Seven complications were reported without any statistical difference between groups. AB - CONCLUSIONS: This study suggests that using a larger human acellular dermal matrix in breast reconstruction offers a potential to increase the initial expander fill volume-to-breast pathology weight ratio and initial expander fill volume-to-final implant volume ratio. Larger matrices can reduce the number of subsequent expansions and may even decrease the risk of postoperative complications. This study also revealed that using a larger matrix is a safe method that does not increase complications. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31829194eb PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e31829194eb [doi] ID - 00006534-201307000-00002 [pii] PP - ppublish LG - English DP - 2013 Jul EZ - 2013/06/29 06:00 DA - 2013/09/18 06:00 DT - 2013/06/29 06:00 YR - 2013 ED - 20130917 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23806904 <286. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23508050 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Pannucci CJ AU - Antony AK AU - Wilkins EG FA - Pannucci, Christopher J FA - Antony, Anuja K FA - Wilkins, Edwin G IN - Pannucci, Christopher J. Section of Plastic Surgery, University of Michigan, Ann Arbor, MI 48109, USA. cpannucc@umich.edu TI - The impact of acellular dermal matrix on tissue expander/implant loss in breast reconstruction: an analysis of the tracking outcomes and operations in plastic surgery database. SO - Plastic & Reconstructive Surgery. 132(1):1-10, 2013 Jul AS - Plast Reconstr Surg. 132(1):1-10, 2013 Jul NJ - Plastic and reconstructive surgery VO - 132 IP - 1 PG - 1-10 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - Adult MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - *Mammaplasty/mt [Methods] MH - *Medical Records MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Retrospective Studies MH - *Risk Assessment/mt [Methods] MH - *Surgery, Plastic/sn [Statistics & Numerical Data] MH - Time Factors MH - *Tissue Expansion Devices MH - United States/ep [Epidemiology] AB - BACKGROUND: Use of acellular dermal matrix in breast reconstruction has been associated with increased complications. However, existing studies are generally small, from single centers, and underpowered to control for confounding using regression techniques. Here, the Tracking Outcomes and Operations in Plastic Surgery database was used to examine the effect of acellular dermal matrix on expander/implant loss when controlling for other confounders. AB - METHODS: Analysis was limited to patients having tissue expander or implant-based breast reconstruction. Surgeon-reported data, International Classification of Diseases, Ninth Edition codes, and Current Procedural Terminology codes were used to identify independent variables. The dependent variable of interest was 30-day rates of tissue expander or implant loss. Bivariate statistics were performed. Multivariable logistic regression identified independent predictors of expander/implant loss when controlling for other confounders. AB - RESULTS: Data were available for 14,249 patients. The overall rate of expander/implant loss was 2.05 percent. Bivariate analysis demonstrated acellular dermal matrix was associated with an absolute increase in expander/implant loss of 0.7 percent (1.88 percent versus 2.58 percent, p = 0.012). The regression model demonstrated that rising body mass index, current smoking, and presence of diabetes were each independent predictors of expander/implant loss. When controlling for all other identified confounders, use of acellular dermal matrix was associated with a significant increase in expander/implant loss (odds ratio, 1.42; 95 percent confidence interval, 1.04 to 1.94; p = 0.026). AB - CONCLUSIONS: Thirty-day risk for expander/implant loss after tissue expander or implant-based breast reconstruction was 2.05 percent. Use of acellular dermal matrix was associated with a 0.7 percent absolute risk increase for expander/implant loss. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318290f917 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e318290f917 [doi] PP - ppublish LG - English DP - 2013 Jul EZ - 2013/03/20 06:00 DA - 2013/09/18 06:00 DT - 2013/03/20 06:00 YR - 2013 ED - 20130917 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23508050 <287. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23714788 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Reish RG AU - Damjanovic B AU - Austen WG Jr AU - Winograd J AU - Liao EC AU - Cetrulo CL AU - Balkin DM AU - Colwell AS FA - Reish, Richard G FA - Damjanovic, Branimir FA - Austen, William G Jr FA - Winograd, Jonathan FA - Liao, Eric C FA - Cetrulo, Curtis L FA - Balkin, Daniel M FA - Colwell, Amy S IN - Reish, Richard G. Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. TI - Infection following implant-based reconstruction in 1952 consecutive breast reconstructions: salvage rates and predictors of success. SO - Plastic & Reconstructive Surgery. 131(6):1223-30, 2013 Jun AS - Plast Reconstr Surg. 131(6):1223-30, 2013 Jun NJ - Plastic and reconstructive surgery VO - 131 IP - 6 PG - 1223-30 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Anti-Bacterial Agents/tu [Therapeutic Use] MH - Body Mass Index MH - *Breast Implants MH - Breast Neoplasms/th [Therapy] MH - Chemoradiotherapy, Adjuvant MH - Female MH - Humans MH - Infusions, Intravenous MH - *Mammaplasty MH - Mastectomy MH - Methicillin-Resistant Staphylococcus aureus MH - Middle Aged MH - Necrosis MH - Postoperative Complications/et [Etiology] MH - *Postoperative Complications/su [Surgery] MH - Prosthesis-Related Infections/et [Etiology] MH - *Prosthesis-Related Infections/su [Surgery] MH - Recurrence MH - Reoperation MH - Retrospective Studies MH - Risk Factors MH - *Salvage Therapy MH - Skin/pa [Pathology] MH - Smoking/ae [Adverse Effects] MH - Staphylococcal Infections/et [Etiology] MH - Staphylococcal Infections/su [Surgery] MH - Surgical Wound Infection/et [Etiology] MH - *Surgical Wound Infection/su [Surgery] MH - Treatment Outcome AB - BACKGROUND: Few studies address salvage rates for infection in implant-based breast reconstruction. An understanding of success rates and clinical predictors of failure may help guide management. AB - METHOD: A retrospective analysis of multisurgeon consecutive implant reconstructions from 2004 to 2010 was performed. AB - RESULTS: Immediate implant-based reconstructions (n=1952) were performed in 1241 patients. Ninety-nine reconstruction patients (5.1 percent) were admitted for breast erythema and had a higher incidence of smoking (p=0.007), chemotherapy (p=0.007), radiation therapy (p=0.001), and mastectomy skin necrosis (p<0.0001). There was no difference in age, body mass index, or acellular dermal matrix usage. With intravenous antibiotics, 25 (25.3 percent) reconstruction patients cleared the infection, whereas 74 (74.7 percent) underwent attempted operative salvage (n=18) or explantation (n=56). Patients who failed to clear infection had a higher mean white blood cell count at admission (p<0.0001). Of the attempted operative salvage group, 12 cleared the infection with immediate implant exchange and six eventually lost the implant. Patients who failed implant salvage were more likely to have methicillin-resistant Staphylococcus aureus (p=0.004). The total explantation rate was 3.2 percent. Following explantation, 32 patients underwent attempted secondary tissue expander insertion. Twenty-six were successful and six had recurrent infection and implant loss. There were no differences in time interval to tissue expander insertion between successful and unsuccessful secondary operations. AB - CONCLUSIONS: Salvage with intravenous antibiotics and implant exchange was successful in 37.3 percent of patients. Smoking, irradiation, chemotherapy, and mastectomy skin necrosis were predictors for developing infection. Patients with a higher white blood cell count at admission and methicillin-resistant S. aureus were more likely to fail implant salvage. There was no association with time interval to tissue expander insertion and secondary explantation. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 0 (Anti-Bacterial Agents) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31828bd377 PT - Journal Article ID - 10.1097/PRS.0b013e31828bd377 [doi] ID - 00006534-201306000-00002 [pii] PP - ppublish LG - English DP - 2013 Jun EZ - 2013/05/30 06:00 DA - 2013/08/03 06:00 DT - 2013/05/30 06:00 YR - 2013 ED - 20130802 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23714788 <288. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23426233 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fahrenbach EN AU - Qi C AU - Ibrahim O AU - Kim JY AU - Alam M FA - Fahrenbach, Elizabeth N FA - Qi, Chao FA - Ibrahim, Omer FA - Kim, John Y FA - Alam, Murad IN - Fahrenbach, Elizabeth N. Department of Medicine, Loyola-Stritch School of Medicine, Maywood, Illinois, USA. TI - Resistance of acellular dermal matrix materials to microbial penetration. SO - JAMA Dermatology. 149(5):571-5, 2013 May AS - JAMA Dermatol.. 149(5):571-5, 2013 May NJ - JAMA dermatology VO - 149 IP - 5 PG - 571-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 101589530 IO - JAMA Dermatol SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis/ae [Adverse Effects] MH - *Acellular Dermis/mi [Microbiology] MH - Biocompatible Materials MH - Candida albicans MH - Collagen/ae [Adverse Effects] MH - Humans MH - *Materials Testing MH - Pseudomonas aeruginosa MH - Staphylococcus aureus MH - Streptococcus pyogenes AB - IMPORTANCE: Acellular dermal matrices have many current and potential applications, but their long-term safety has not been extensively studied. In particular, limited information exists regarding such materials' resistance to infection. AB - OBJECTIVE: To assess the resistance to microbial penetration of common acellular dermal matrix materials used in reconstruction after skin cancer excision, treatment of chronic ulcers and burns, breast reconstruction, hernia repairs, and other applications. AB - DESIGN: Comparative in vitro study of 4 commercially available dermal substitutes for their ability to act as barriers to penetration by common skin pathogens. AB - SETTING: University-based dermatology and plastic surgery departments and a hospital microbiology laboratory. AB - MATERIALS: Four commercially available dermal substitutes, including AlloDerm (LifeCell), FlexHD (Musculoskeletal Transplant Foundation), Strattice (LifeCell), and NeoForm (Mentor Corporation). AB - INTERVENTION: We tested the 4 dermal matrix materials with the following 4 organisms commonly implicated in wound infections: Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes, and Candida albicans. Each material was inoculated with the same concentration of each pathogen. AB - MAIN OUTCOME MEASURE: The number of bacterial colonies grown on blood agar plates. AB - RESULTS: AlloDerm and rehydrated FlexHD were found to be the best barriers to penetration by P. aeruginosa. AlloDerm, FlexHD, and Strattice also prevented penetration by S. aureus and S. pyogenes; NeoForm was less effective in withstanding these organisms. The results of this study were inconclusive with regard to C. albicans penetration. AB - CONCLUSIONS AND RELEVANCE: Three of the 4 commonly used acellular dermal matrix materials are resistant to in vitro penetration by S. aureus and S. pyogenes and partially resistant to P. aeruginosa. Resistance to fungal pathogens is uncertain. Antimicrobial differences across matrix materials may influence their selection for particular uses, such as treatment of refractory leg ulcers or reconstruction after skin cancer excision. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 0 (FlexHD) RN - 0 (NeoForm) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 2168-6084 IL - 2168-6068 DO - https://dx.doi.org/10.1001/jamadermatol.2013.1741 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 1654911 [pii] ID - 10.1001/jamadermatol.2013.1741 [doi] PP - ppublish LG - English DP - 2013 May EZ - 2013/02/22 06:00 DA - 2013/08/02 06:00 DT - 2013/02/22 06:00 YR - 2013 ED - 20130801 RD - 20160524 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23426233 <289. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23898434 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lee JH AU - Park KR AU - Kim TG AU - Ha JH AU - Chung KJ AU - Kim YH AU - Lee SJ AU - Kang SH FA - Lee, Jun Ho FA - Park, Ki Rin FA - Kim, Tae Gon FA - Ha, Ju-Ho FA - Chung, Kyu-Jin FA - Kim, Yong-Ha FA - Lee, Soo Jung FA - Kang, Soo Hwan IN - Lee, Jun Ho. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. TI - A Comparative Study of CG CryoDerm and AlloDerm in Direct-to-Implant Immediate Breast Reconstruction. SO - Archives of Plastic Surgery. 40(4):374-9, 2013 Jul AS - Arch. plast. surg.. 40(4):374-9, 2013 Jul NJ - Archives of plastic surgery VO - 40 IP - 4 PG - 374-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723998 CP - Korea (South) KW - Acellular dermis; Breast implantation; Mammaplasty AB - BACKGROUND: To date, various types of acellular dermal matrix (ADM) have been developed for clinical use. AlloDerm is the most familiar type of ADM to most surgeons in breast reconstruction. It is prepared by freeze-drying. CG CryoDerm is the first form of ADM that requires no drying process. Therefore, theoretically, it has a higher degree of preservation of the dermal structures than AlloDerm. We conducted this study to compare the clinical course and postoperative outcomes of patients who underwent direct-to-implant breast reconstructions using AlloDerm and those who did using CG CryoDerm. AB - METHODS: We performed a retrospective analysis of the medical records in a consecutive series of 50 patients who underwent direct-to-implant breast reconstruction using AlloDerm (n=31) or CryoDerm (n=19). We then compared the clinical course and postoperative outcomes of the two groups based on the overall incidence of complications and the duration of drainage. AB - RESULTS: The mean follow-up period was 16 months. There were no significant differences in the overall incidence of complications (seroma, infection, skin flap necrosis, capsular contracture, and implant loss) between the two groups. Nor was there any significant difference in the duration of drainage. AB - CONCLUSIONS: CG CryoDerm has the merits of short preparation time and easy handling during surgery. Our results indicate that CG CryoDerm might be an alternative allograft material to AlloDerm in direct-to-implant breast reconstruction. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2013.40.4.374 PT - Journal Article ID - 10.5999/aps.2013.40.4.374 [doi] ID - PMC3723998 [pmc] PP - ppublish PH - 2013/03/15 [received] PH - 2013/04/26 [revised] PH - 2013/05/12 [accepted] LG - English EP - 20130717 DP - 2013 Jul EZ - 2013/07/31 06:00 DA - 2013/07/31 06:01 DT - 2013/07/31 06:00 YR - 2013 ED - 20130730 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23898434 <290. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23629113 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Garcia O Jr AU - Scott JR FA - Garcia, Onelio Jr FA - Scott, Jeffrey R IN - Garcia, Onelio Jr. Division of Plastic Surgery, University of Miami, Miami, Fl, USA. TI - Analysis of acellular dermal matrix integration and revascularization following tissue expander breast reconstruction in a clinically relevant large-animal model. SO - Plastic & Reconstructive Surgery. 131(5):741e-51e, 2013 May AS - Plast Reconstr Surg. 131(5):741e-51e, 2013 May NJ - Plastic and reconstructive surgery VO - 131 IP - 5 PG - 741e-51e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mammary Glands, Animal/su [Surgery] MH - Mastectomy/mt [Methods] MH - Microcirculation/ph [Physiology] MH - *Models, Animal MH - *Neovascularization, Physiologic/ph [Physiology] MH - Postoperative Complications MH - *Sus scrofa MH - *Tissue Expansion Devices MH - Tissue Scaffolds AB - BACKGROUND: Postmastectomy breast reconstruction remains one of the most frequently performed plastic surgery procedures in the United States. Acellular dermal matrix has been used extensively in expander-implant breast reconstruction and therefore is an appropriate material to be used to develop a clinically relevant animal model of breast reconstruction. AB - METHODS: The study population consisted of 18 female Yorkshire pigs, which were assigned randomly to bilateral expander breast reconstruction with either AlloMax Surgical Graft or AlloDerm Regenerative Tissue Matrix (n = 9 per group). Each group was further randomized to 4-, 8-, or 12-week time points (n = 3), to evaluate integration and neovascularization by means of microcirculatory and histologic techniques. AB - RESULTS: Microcirculatory analysis revealed early acellular dermal matrix angiogenesis at 4 weeks on the skin flap surfaces only, and well-formed vasculature on both acellular dermal matrix surfaces at 8 weeks. Both surfaces were vascularized and exhibited detectable flow at 12 weeks after implantation. Progressive acellular dermal matrix angiogenesis was also histologically observed over time by means of hematoxylin and eosin-stained slides, as indicated by direct vascular identification/scoring at 4, 8, and 12 weeks. AB - CONCLUSIONS: The authors have developed a clinically relevant large-animal model of breast reconstruction using acellular dermal matrix. The acellular dermal matrix inflammatory, neovascularization, and tissue integration response should be evaluated in an in vivo setting that accurately simulates the anatomy, biomaterials, surgical techniques, and timeframes encountered in human postmastectomy breast reconstruction to appropriately predict clinical performance. Neovascularization of the acellular dermal matrix with detectable blood flow took place after postimplantation week 8, a much slower process than previously reported in models not clinically relevant to acellular dermal matrix-assisted tissue expander breast reconstruction. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182865c6d PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e3182865c6d [doi] ID - 00006534-201305000-00021 [pii] PP - ppublish LG - English DP - 2013 May EZ - 2013/05/01 06:00 DA - 2013/07/17 06:00 DT - 2013/05/01 06:00 YR - 2013 ED - 20130716 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23629113 <291. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23629094 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL AU - Sinkin JC AU - Al-Attar A FA - Spear, Scott L FA - Sinkin, Jeremy C FA - Al-Attar, Ali IN - Spear, Scott L. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC20007 , USA. spears@gunet.georgetown.edu TI - Porcine acellular dermal matrix (strattice) in primary and revision cosmetic breast surgery. SO - Plastic & Reconstructive Surgery. 131(5):1140-8, 2013 May AS - Plast Reconstr Surg. 131(5):1140-8, 2013 May NJ - Plastic and reconstructive surgery VO - 131 IP - 5 PG - 1140-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Animals MH - Breast/su [Surgery] MH - *Breast Implants MH - *Collagen MH - Contracture/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Postoperative Complications/pc [Prevention & Control] MH - Postoperative Complications/su [Surgery] MH - *Reoperation/mt [Methods] MH - Retrospective Studies MH - *Surgery, Plastic/mt [Methods] MH - Swine MH - Young Adult AB - BACKGROUND: Although acellular dermal matrix materials have been in use for over a decade in primary and secondary breast reconstruction and in some cosmetic breast surgery, little has been published on the outcomes of these materials for cosmetic applications. AB - METHODS: A retrospective institutional review board-approved review was conducted of all patients who had a specific acellular dermal matrix, Strattice, used for cosmetic breast surgery performed by the senior author (S.L.S.). Patient demographics, indications, surgical findings, and postoperative course were collected and data analyzed using descriptive statistical tools. AB - RESULTS: Between 2008 and 2012, Strattice was used in 43 cosmetic breast operations (75 breasts) performed by the senior author (S.L.S.). Sixty-nine of the 75 breasts (92 percent) were revision operations. Indications included inferior pole support [39 breasts (52 percent)], fold malpositions [28 breasts (37 percent)], capsular contracture [25 breasts (33 percent)], and rippling/palpability [six breasts (8 percent)]. Three patients (six breasts) had Strattice placed during primary augmentation/mastopexy. Seventy-four of the 75 breasts (98.7 percent) had successfully achieved the indication for which the Strattice was placed; one breast (1.2 percent) had some degree of relapse. The global complication rate for all patients in this study is 5.3 percent-two breasts (2.7 percent) had postoperative malposition, one breast (1.2 percent) had bottoming out, and one breast (1.2 percent) developed an infection that resulted in temporary device explantation. AB - CONCLUSIONS: The use of Strattice is safe and may be helpful in the management of certain situations in cosmetic breast surgery, including needed lower pole support, capsular contracture, rippling, and implant malposition. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182865d0c PT - Journal Article ID - 10.1097/PRS.0b013e3182865d0c [doi] ID - 00006534-201305000-00042 [pii] PP - ppublish LG - English DP - 2013 May EZ - 2013/05/01 06:00 DA - 2013/07/17 06:00 DT - 2013/05/01 06:00 YR - 2013 ED - 20130716 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23629094 <292. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23629077 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Krishnan NM AU - Chatterjee A AU - Van Vliet MM AU - Powell SG AU - Rosen JM AU - Nigriny JF FA - Krishnan, Naveen M FA - Chatterjee, Abhishek FA - Van Vliet, Michael M FA - Powell, Stephen G FA - Rosen, Joseph M FA - Nigriny, John F IN - Krishnan, Naveen M. Geisel School of Medicine at Dartmouth 1 Rope Ferry Road, Hanover, N.H. 03755, USA. naveen.m.krishnan@dartmouth.edu TI - A comparison of acellular dermal matrix to autologous dermal flaps in single-stage, implant-based immediate breast reconstruction: a cost-effectiveness analysis. [Review] SO - Plastic & Reconstructive Surgery. 131(5):953-61, 2013 May AS - Plast Reconstr Surg. 131(5):953-61, 2013 May NJ - Plastic and reconstructive surgery VO - 131 IP - 5 PG - 953-61 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implants/ec [Economics] MH - Cost-Benefit Analysis MH - Female MH - Humans MH - *Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Postoperative Complications/ec [Economics] MH - Postoperative Complications/pc [Prevention & Control] MH - Quality-Adjusted Life Years MH - *Surgical Flaps/ec [Economics] AB - BACKGROUND: The use of acellular dermal matrix has allowed for single-stage immediate breast reconstruction after mastectomy at a significantly decreased cost compared with two-stage expander/implant reconstruction. The use of a pedicled autologous dermal flap in the same fashion as acellular dermal matrix in women with larger, ptotic breasts has also allowed for single-stage immediate breast reconstruction with similarly low complication rates and without the added procedural cost of using acellular dermal matrix. There have been no prior studies evaluating whether the added procedural cost for acellular dermal matrix is cost-effective relative to using an autologous dermal flap in single-stage immediate breast reconstruction following mastectomy. AB - METHODS: A comprehensive literature review was conducted to identify published complication rates for single-stage, implant-based immediate breast reconstruction using either acellular dermal matrix or an autologous dermal flap. The probabilities of the most common complications were combined with Medicare Current Procedural Terminology reimbursement codes and expert utility estimates to fit into a decision model to evaluate the cost-effectiveness of acellular dermal matrix. AB - RESULTS: : The decision model revealed a baseline cost difference of $261.72 and a 0.001 increase in the quality-adjusted life years when using acellular dermal matrix, yielding an incremental cost-utility ratio of $261,720 per quality-adjusted life year. Sensitivity analysis showed that acellular dermal matrix was not cost-effective when the complication rate for autologous dermal flaps was below 20 percent. AB - CONCLUSIONS: The authors' study demonstrates that acellular dermal matrix is not a cost-effective technology in patients who can have an autologous dermal flap in single-stage immediate breast reconstruction. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182865a24 PT - Comparative Study PT - Journal Article PT - Meta-Analysis PT - Review ID - 10.1097/PRS.0b013e3182865a24 [doi] ID - 00006534-201305000-00008 [pii] PP - ppublish LG - English DP - 2013 May EZ - 2013/05/01 06:00 DA - 2013/07/17 06:00 DT - 2013/05/01 06:00 YR - 2013 ED - 20130716 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23629077 <293. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23629076 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Butterfield JL FA - Butterfield, Jennifer L IN - Butterfield, Jennifer L. Women's Plastic Surgery & Rejuvenation Centre 4750 East Galbraith Road, Suite 215, Cincinnati, Ohio 45236, USA. butterjl@yahoo.com TI - 440 Consecutive immediate, implant-based, single-surgeon breast reconstructions in 281 patients: a comparison of early outcomes and costs between SurgiMend fetal bovine and AlloDerm human cadaveric acellular dermal matrices. SO - Plastic & Reconstructive Surgery. 131(5):940-51, 2013 May AS - Plast Reconstr Surg. 131(5):940-51, 2013 May NJ - Plastic and reconstructive surgery VO - 131 IP - 5 PG - 940-51 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Animals MH - Breast Implants/ec [Economics] MH - *Breast Implants MH - Breast Neoplasms/ec [Economics] MH - *Breast Neoplasms/su [Surgery] MH - Cadaver MH - Cattle MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Hospital Costs/sn [Statistics & Numerical Data] MH - Humans MH - Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications/ec [Economics] MH - Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Tissue Expansion Devices/ec [Economics] MH - Treatment Outcome AB - BACKGROUND: A 2010 nationwide survey of plastic and reconstructive surgeons indicated that approximately 83 percent performed predominantly implant-based breast reconstruction, with acellular dermal matrix used by approximately half of those practitioners. Although the medical literature documents well over 2000 cases of breast reconstruction with matrices, relatively few cases using other than human cadaveric acellular dermal matrices have been reported. The author compared complications and costs using SurgiMend fetal bovine and AlloDerm human cadaveric acellular dermal matrices. AB - METHODS: A retrospective review of a single surgeon's 5-year experience was performed for consecutive, nonrandomized immediate breast reconstructions with acellular dermal matrix from 2005 to 2010. AB - RESULTS: Two hundred eighty-one patients had 440 implant-based reconstructions using SurgiMend [222 patients (79.0 percent)] or AlloDerm [59 patients (21.0 percent)]. No significant differences in complication rates were observed between SurgiMend and AlloDerm for hematoma, infection, major skin necrosis, or breast implant removal. Seroma was the most prevalent complication; the seroma rate for AlloDerm (15.7 percent) was significantly greater than that for SurgiMend (8.3 percent). Using recent product costs for equivalently sized AlloDerm and SurgiMend units, the cost of SurgiMend was $1024 less per breast than AlloDerm. AB - CONCLUSIONS: SurgiMend fetal bovine and AlloDerm human cadaveric acellular dermal matrices demonstrate similar rates of major early complications in breast reconstruction in this study. This similarity in complication rates between SurgiMend and AlloDerm and the cost savings seen with the use of SurgiMend are factors for the surgeon to consider in choosing a matrix for breast reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: : Therapeutic, III. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182865ab3 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e3182865ab3 [doi] ID - 00006534-201305000-00006 [pii] PP - ppublish LG - English DP - 2013 May EZ - 2013/05/01 06:00 DA - 2013/07/17 06:00 DT - 2013/05/01 06:00 YR - 2013 ED - 20130716 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23629076 <294. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23385983 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Weichman KE AU - Cemal Y AU - Albornoz CR AU - McCarthy CM AU - Pusic AL AU - Mehrara BJ AU - Disa JJ FA - Weichman, Katie E FA - Cemal, Yeliz FA - Albornoz, Claudia R FA - McCarthy, Colleen M FA - Pusic, Andrea L FA - Mehrara, Babak J FA - Disa, Joseph J IN - Weichman, Katie E. Department of Plastic Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. TI - Unilateral preoperative chest wall irradiation in bilateral tissue expander breast reconstruction with acellular dermal matrix: a prospective outcomes analysis. SO - Plastic & Reconstructive Surgery. 131(5):921-7, 2013 May AS - Plast Reconstr Surg. 131(5):921-7, 2013 May NJ - Plastic and reconstructive surgery VO - 131 IP - 5 PG - 921-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Body Mass Index MH - Breast Neoplasms/ep [Epidemiology] MH - *Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Case-Control Studies MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy, Segmental MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pa [Pathology] MH - Postoperative Complications/pc [Prevention & Control] MH - Prospective Studies MH - Radiation Injuries/ep [Epidemiology] MH - Retrospective Studies MH - Risk Factors MH - Smoking/ep [Epidemiology] MH - Surgical Flaps/pa [Pathology] MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Prior breast irradiation increases the rate of postoperative complications, including capsular contracture, in tissue expander/implant reconstruction. Acellular dermal matrix is heralded to decrease capsular contracture, but recent evidence suggests a possible increase in postoperative complications. The authors evaluated outcomes in patients undergoing bilateral tissue expander/implant reconstruction with acellular dermal matrix in the setting of prior unilateral irradiation. AB - METHODS: A case-control study was conducted on all patients undergoing bilateral, acellular dermal matrix-assisted, tissue expander/implant reconstruction with a history of previous unilateral irradiation at Memorial Sloan-Kettering Cancer Center. Complication rates were compared. AB - RESULTS: Twenty-three patients met inclusion criteria and had an average follow-up of 19 months (range, 4 to 60 months). The perioperative infection rate was 21.7 percent (n = 5) in irradiated breasts and 4.3 percent (n = 1) in control breasts (p = 0.079). Mastectomy skin flap necrosis, explantation, hematoma, and seroma rates were not significantly different between the groups. Sixty percent of patients had irradiated breast contracture that was one Baker grade greater than that in the nonirradiated breast. Body mass index greater than 25 and smoking history were significant independent risk factors for early postoperative complications in univariate analysis (p = 0.01). AB - CONCLUSIONS: Previous irradiation does not appear to increase the risk of early postoperative complications associated with acellular dermal matrix use in tissue expander/implant breast reconstruction. However, body mass index greater than 25 and smoking history are cause for caution. In addition, acellular dermal matrix does not appear to affect the degree of capsular contracture formation in the setting of prior irradiation. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: : Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31828659c1 PT - Journal Article ID - 10.1097/PRS.0b013e31828659c1 [doi] PP - ppublish LG - English DP - 2013 May EZ - 2013/02/07 06:00 DA - 2013/07/17 06:00 DT - 2013/02/07 06:00 YR - 2013 ED - 20130716 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23385983 <295. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23204883 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Rawlani V AU - Fiuk J AU - Johnson SA AU - Buck DW 2nd AU - Hirsch E AU - Hansen N AU - Khan S AU - Fine NA AU - Kim JY FA - Rawlani, Vinay FA - Fiuk, Julia FA - Johnson, Sarah A FA - Buck, Donald W 2nd FA - Hirsch, Elliot FA - Hansen, Nora FA - Khan, Seema FA - Fine, Neil A FA - Kim, John Ys IN - Rawlani, Vinay. Division of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. TI - The effect of incision choice on outcomes of nipple-sparing mastectomy reconstruction. SO - Canadian Journal of Plastic Surgery. 19(4):129-33, 2011 AS - Can. j. plast. surg.. 19(4):129-33, 2011 NJ - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique VO - 19 IP - 4 PG - 129-33 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9434932 IO - Can J Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269196 CP - Canada KW - Acellular dermis; Breast reconstruction; Nipple necrosis; Nipple-areola complex; Nipple-sparing mastectomy; Tissue expansion AB - INTRODUCTION: The indications for nipple-sparing mastectomy (NSM) are broadening as more breast surgeons appreciate the utility of preserving the nipple-areolar complex. A number of incision locations are available to the mastectomy surgeon, including inframammary, lateral and periareolar approaches. The present study investigated the effect of these three incisions on reconstructive outcomes; specifically, nipple necrosis. AB - METHODS: A single-centre, retrospective review of 37 breast NSM reconstructions treated with immediate tissue expander reconstruction with acellular dermis between 2007 and 2008 was performed. The primary outcome was the incidence of nipple necrosis associated with periareolar, lateral and inframammary incisions. Secondary outcomes were the effects of radiation, chemotherapy and breast size on nipple necrosis. AB - RESULTS: Thirty-seven breast procedures performed on 20 patients were included in the present study. Periareolar incisions were used in 21 cases, lateral incisions in 14 and inframammary incisions in two. The periareolar incision was associated with a significantly higher incidence of nipple necrosis compared with lateral or inframammary incisions (38.1% versus 6.3%, P=0.028). Patients receiving breast radiation (45.5% versus 15.4%, P=0.066) and those with larger breast size (540.4 g versus 425.7 g, P=0.130) also demonstrated a modest trend toward an increased rate of nipple necrosis. AB - CONCLUSION: The periareolar incision results in a higher rate of nipple necrosis following NSM and immediate tissue expander breast reconstruction. Using the lateral or inframammary incision reduces the incidence of nipple necrosis and may help improve overall reconstructive and cosmetic outcomes. ES - 1918-1507 IL - 1195-2199 PT - Journal Article ID - PMC3269196 [pmc] PP - ppublish LG - English DP - 2011 EZ - 2011/01/01 00:00 DA - 2011/01/01 00:01 DT - 2012/12/04 06:00 YR - 2011 ED - 20130704 RD - 20130705 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23204883 <296. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23252505 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Blechman KM AU - Karp NS AU - Levovitz C AU - Guth AA AU - Axelrod DM AU - Shapiro RL AU - Choi M FA - Blechman, Keith M FA - Karp, Nolan S FA - Levovitz, Chaya FA - Guth, Amber A FA - Axelrod, Deborah M FA - Shapiro, Richard L FA - Choi, Mihye IN - Blechman, Keith M. New York University, School of Medicine, NY, USA. TI - The lateral inframammary fold incision for nipple-sparing mastectomy: outcomes from over 50 immediate implant-based breast reconstructions. SO - Breast Journal. 19(1):31-40, 2013 Jan-Feb AS - Breast J. 19(1):31-40, 2013 Jan-Feb NJ - The breast journal VO - 19 IP - 1 PG - 31-40 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adipose Tissue/tr [Transplantation] MH - Adult MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/pc [Prevention & Control] MH - *Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/pa [Pathology] MH - Carcinoma, Ductal, Breast/pc [Prevention & Control] MH - *Carcinoma, Ductal, Breast/su [Surgery] MH - Cellulitis/et [Etiology] MH - Debridement MH - Dissection MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Subcutaneous/ae [Adverse Effects] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Necrosis/et [Etiology] MH - Necrosis/su [Surgery] MH - Nipples/pa [Pathology] MH - *Nipples/su [Surgery] MH - Organ Sparing Treatments MH - Retrospective Studies MH - Sentinel Lymph Node Biopsy MH - Surgical Flaps/ae [Adverse Effects] MH - Surgical Flaps/pa [Pathology] MH - Surgical Flaps/su [Surgery] MH - *Surgical Flaps MH - Time Factors MH - Treatment Outcome AB - Nipple-sparing mastectomy (NSM) as a therapeutic or prophylactic procedure for breast cancer is rapidly gaining popularity as the literature continues to support it safety. The lateral inframammary fold (IMF) approach provides adequate exposure and eliminates visible scars on the anterior surface of the breast, making this incision cosmetically superior to radial or periareolar approaches. We reviewed 55 consecutive NSMs performed through a lateral IMF incision with immediate implant-based reconstruction, with or without tissue expansion, between June 2008 and June 2011. Prior to incision, breasts were lightly infiltrated with dilute anesthetic solution with epinephrine. Sharp dissection, rather than electrocautery, was used as much as possible to minimize thermal injury to the mastectomy flap. When indicated, acellular dermal matrix was placed as an inferolateral sling. Subsequent fat grafting to correct contour deformities was performed in select patients. Three-dimensional (3D) photographs assessed changes in volume, antero-posterior projection, and ptosis. Mean patient age was 46 years, and mean follow-up time was 12 months. Twelve mastectomies (22%) were therapeutic, and the remaining 43 (78%) were prophylactic. Seven of the nine sentinel lymph node biopsies (including one axillary dissection) (78%) were performed through the lateral IMF incision without the need for a counter-incision. Acellular dermal matrix was used in 34 (62%) breasts. Average permanent implant volume was 416 cc (range 176-750 cc), and average fat grafting volume was 86 cc (range 10-177 cc). In one patient a positive intraoperative subareolar biopsy necessitated resection of the nipple-areola complex (NAC), and in two other patients NAC resection was performed at a subsequent procedure based on the final pathology report. Mastectomy flap necrosis, requiring operative debridement, occurred in two breasts (4%), both in the same patient. One of these breasts required a salvage latissimus dorsi myocutaneous flap to complete the reconstruction. Three nipples (6%) required office debridement for partial necrosis and operative reconstruction later. No patient had complete nipple necrosis. No statistically significant differences existed between therapeutic and prophylactic mastectomies for developing partial skin and/or nipple necrosis (p = 0.35). Three episodes (5%) of cellulitis occurred, which responded to antibiotics without the need for explantation. Morphological outcomes using 3D scan measurements showed reconstructed breasts were larger, more projected, and less ptotic than the preoperative breasts (196 versus 248 cc, 80 versus 90 mm, 146 versus 134 mm, p < 0.01 for each parameter). Excellent results can be achieved with immediate implant-based reconstruction of NSM through a lateral IMF incision. NAC survival is reliable, and complication rates are low. Copyright © 2012 Wiley Periodicals, Inc. ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12043 PT - Journal Article ID - 10.1111/tbj.12043 [doi] PP - ppublish LG - English EP - 20121217 DP - 2013 Jan-Feb EZ - 2012/12/21 06:00 DA - 2013/06/26 06:00 DT - 2012/12/21 06:00 YR - 2013 ED - 20130624 RD - 20130110 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23252505 <297. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23321393 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Martin L AU - O'Donoghue JM AU - Horgan K AU - Thrush S AU - Johnson R AU - Gandhi A AU - Association of Breast Surgery and the British Association of Plastic, Reconstructive and Aesthetic Surgeons FA - Martin, L FA - O'Donoghue, J M FA - Horgan, K FA - Thrush, S FA - Johnson, R FA - Gandhi, A FA - Association of Breast Surgery and the British Association of Plastic, Reconstructive and Aesthetic Surgeons IN - Martin, L. Aintree University Hospital, Longmoor Lane, Aintree, Liverpool L9 7AL, UK. lee.martin@aintree.nhs.uk TI - Acellular dermal matrix (ADM) assisted breast reconstruction procedures: joint guidelines from the Association of Breast Surgery and the British Association of Plastic, Reconstructive and Aesthetic Surgeons. SO - European Journal of Surgical Oncology. 39(5):425-9, 2013 May AS - Eur J Surg Oncol. 39(5):425-9, 2013 May NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 39 IP - 5 PG - 425-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis MH - Breast Implantation/mt [Methods] MH - Female MH - Humans MH - Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Pectoralis Muscles/su [Surgery] MH - *Postoperative Complications/pc [Prevention & Control] MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices MH - United Kingdom MH - United States AB - Tissue expansion with delayed insertion of a definitive prosthesis is the most common form of immediate breast reconstruction performed in the United Kingdom. However, achieving total muscle coverage of the implant and natural ptosis is a key technical challenge. The use of acellular dermal matrices (ADM) to supplement the pectoralis major muscle at the lower and lateral aspects of the breast has been widely adopted in the UK, potentially allowing for a single stage procedure. There is however little published data on the clinical and quality criteria for its use, and no long term follow-up. The guidelines have been jointly produced by the Association of Breast Surgery and the British Association of Plastic, Reconstructive and Aesthetic Surgeons and their aims are: to inform those wishing to undertake ADM assisted breast reconstruction and, to identify clinical standards and quality indicators for audit purposes. The guidelines are based on expert opinion of a multi-disciplinary working group, who are experienced in the technique, and a review of the published data. Copyright © 2012 Elsevier Ltd. All rights reserved. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(12)01351-0 DO - https://dx.doi.org/10.1016/j.ejso.2012.12.012 PT - Journal Article PT - Practice Guideline ID - S0748-7983(12)01351-0 [pii] ID - 10.1016/j.ejso.2012.12.012 [doi] PP - ppublish PH - 2012/08/09 [received] PH - 2012/11/28 [revised] PH - 2012/12/10 [accepted] LG - English EP - 20130113 DP - 2013 May EZ - 2013/01/17 06:00 DA - 2013/06/15 06:00 DT - 2013/01/17 06:00 YR - 2013 ED - 20130614 RD - 20161125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23321393 <298. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23730154 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Macadam SA AU - Lennox PA FA - Macadam, Sheina A FA - Lennox, Peter A IN - Macadam, Sheina A. Division of Plastic and Reconstructive Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia. TI - Acellular dermal matrices: Use in reconstructive and aesthetic breast surgery. SO - Canadian Journal of Plastic Surgery. 20(2):75-89, 2012 AS - Can. j. plast. surg.. 20(2):75-89, 2012 NJ - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique VO - 20 IP - 2 PG - 75-89 PI - Journal available in: Print PI - Citation processed from: Print JC - 9434932 IO - Can J Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383551 CP - Canada KW - Acelluar dermal matrices; Breast aesthetic surgery; Breast reconstruction; Economic analysis AB - Acellular dermal matrices (ADMs) were first described for use in breast surgery in 2001. Since this initial report, ADMs have become an increasingly common component of implant-based breast procedures. ADMs have shown promise for use in both aesthetic and reconstructive breast surgery; however, concerns about their use remain because of the significant costs associated with these products. The present article reviews the history of ADM use in breast surgery and the outcomes reported to date. Common techniques for placement of ADMs in aesthetic revisionary and breast reconstruction surgery are provided, and use in the setting of chest wall irradiation and capsular contracture is discussed. Finally, the authors comment on the cost implications of these products in the Canadian and American health care systems. OA - Publisher: Les matrices dermiques acellulaires (MDA) ont d'abord ete decrites dans le cadre d'une utilisation en chirurgie mammaire en 2001. Depuis ce premier rapport, l'utilisation des MDA se generalise pour les interventions d'implants mammaires. Les MDA sont prometteuses en chirurgie mammaire esthetique et reconstructive, mais il reste des preoccupations quant a leur utilisation en raison a leur cout tres eleve. Le present article permet d'analyser l'evolution de l'utilisation des MDA en chirurgie mammaire et les issues declarees jusqu'a maintenant. Les techniques courantes d'implantation des MDA dans le cadre de chirurgies mammaires de revision esthetique et de reconstruction sont presentees, et leur utilisation en irradiation de la paroi thoracique et de la contracture capsulaire est exposee. Enfin, les auteurs commentent les repercussions sur les couts de ces produits dans le systeme de sante canadien et americain.; Language: French IS - 1195-2199 IL - 1195-2199 PT - Journal Article ID - PMC3383551 [pmc] PP - ppublish LG - English DP - 2012 EZ - 2013/06/05 06:00 DA - 2013/06/05 06:01 DT - 2013/06/05 06:00 YR - 2012 ED - 20130605 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23730154 <299. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21862916 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gurunluoglu R AU - Gurunluoglu A AU - Williams SA AU - Tebockhorst S FA - Gurunluoglu, Raffi FA - Gurunluoglu, Aslin FA - Williams, Susan A FA - Tebockhorst, Seth IN - Gurunluoglu, Raffi. Plastic and Reconstructive Surgery, Denver Health Medical Center, University of Colorado Health Sciences, Denver, Colorado 80204, USA. raffi.gurunluoglu@dhha.org TI - Current trends in breast reconstruction: survey of American Society of Plastic Surgeons 2010. SO - Annals of Plastic Surgery. 70(1):103-10, 2013 Jan AS - Ann Plast Surg. 70(1):103-10, 2013 Jan NJ - Annals of plastic surgery VO - 70 IP - 1 PG - 103-10 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Attitude of Health Personnel MH - Female MH - Health Care Surveys MH - Humans MH - Male MH - Mammaplasty/mt [Methods] MH - Mammaplasty/sn [Statistics & Numerical Data] MH - *Mammaplasty/td [Trends] MH - Mastectomy MH - Middle Aged MH - Patient Satisfaction/sn [Statistics & Numerical Data] MH - Postoperative Complications/ep [Epidemiology] MH - Practice Patterns, Physicians'/sn [Statistics & Numerical Data] MH - *Practice Patterns, Physicians'/td [Trends] MH - Retrospective Studies MH - Surgical Flaps/ut [Utilization] MH - Surveys and Questionnaires MH - United States AB - BACKGROUND: We conducted a retrospective survey of American Society of Plastic Surgeons to ascertain the current trends in breast reconstruction (BR). AB - METHODS: Surveys were sent to 2250 active American Society of Plastic Surgeons members by e-mail with a cover letter including the link using Survey Monkey for the year 2010. In all, 489 surveys (a response rate of 21.7%) were returned. Three hundred fifty-eight surveys from respondents performing BR in their practices were included in the study. The survey included questions on surgeon demographics, practice characteristics, BR after mastectomy, number of BR per year, type and timing of BR, use of acellular dermal matrix, reconstructive choices in the setting of previous irradiation and in patients requiring postmastectomy radiation therapy, timing of contralateral breast surgery, fat grafting, techniques used for nipple-areola reconstruction, the complications, and physician satisfaction and physician reported patient satisfaction. Returned responses were tabulated and assessed. AB - RESULTS: After prophylactic mastectomy, 16% of BRs were performed. In all, 81.2% of plastic surgeons predominantly performed immediate BR. In patients requiring postmastectomy radiation therapy, 81% did not perform immediate BR. Regardless of practice setting and laterality of reconstruction, 82.7% of respondents predominantly performed implant-based BR. Half of the plastic surgeons performing prosthetic BR used acellular dermal matrix. Only 14% of plastic surgeons predominantly performed autologous BR. Surgeons in solo, plastic surgery group practices, and multispecialty group practices preferred implant-based BR for both unilateral and bilateral cases more frequently than those in academic practices (P < 0.05). Overall, plastic surgeons in academic settings preferred autologous BR more frequently than those in other practice locations (P < 0.05). Of total respondents, 64.8% did not perform microsurgical BR at all; 28% reported performing deep inferior epigastric perforator flap BR. Pedicled transverse rectus abdominis myocutaneous flap was the most often used option for unilateral autologous reconstruction, whereas deep inferior epigastric perforator flap was the most commonly used technique for bilateral BR. The overall complication rate reported by respondents was 11%. AB - CONCLUSION: The survey provides an insight to the current trends in BR practice with respect to surgeon and practice setting characteristics. Although not necessarily the correct best practices, the survey does demonstrate a likely portrayal of what is being practiced in the United States in the area of BR. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31822ed5ce PT - Journal Article ID - 10.1097/SAP.0b013e31822ed5ce [doi] PP - ppublish LG - English DP - 2013 Jan EZ - 2011/08/25 06:00 DA - 2013/05/25 06:00 DT - 2011/08/25 06:00 YR - 2013 ED - 20130523 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21862916 <300. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21862915 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hanna KR AU - DeGeorge BR Jr AU - Mericli AF AU - Lin KY AU - Drake DB FA - Hanna, Kasandra R FA - DeGeorge, Brent R Jr FA - Mericli, Alexander F FA - Lin, Kant Y FA - Drake, David B IN - Hanna, Kasandra R. Department of Plastic and Reconstructive Surgery, University of Virginia, Charlottesville, VA 22908, USA. TI - Comparison study of two types of expander-based breast reconstruction: acellular dermal matrix-assisted versus total submuscular placement. SO - Annals of Plastic Surgery. 70(1):10-5, 2013 Jan AS - Ann Plast Surg. 70(1):10-5, 2013 Jan NJ - Annals of plastic surgery VO - 70 IP - 1 PG - 10-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy MH - Middle Aged MH - Patient Satisfaction/sn [Statistics & Numerical Data] MH - Postoperative Complications/ep [Epidemiology] MH - Reoperation/sn [Statistics & Numerical Data] MH - Retrospective Studies MH - Surveys and Questionnaires MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion/mt [Methods] MH - *Tissue Expansion Devices AB - Recent reported complications have called some authors to express concern regarding the increased popularity of acellular dermal matrix (ADM)-based breast reconstruction, and its role as an alternative to traditional total submuscular approaches. To address this issue, we compared tissue expansion properties, complication rates, and patient satisfaction for both operative techniques at the same institution. A retrospective review was completed on 75 patients and 100 tissue expander/implant-based breast reconstructions at a single academic institution from 2007 to 2010. Of these cases, 31 patients were reconstructed with ADM and 44 with a submuscular coverage technique. Total complications including seroma, hematoma, infection, skin necrosis, and explantation did not significantly differ between groups (n = 13 for ADM vs. 17 for submuscular, P = 0.814). Consistent with prior reports, ADM-based reconstructions were associated with significantly increased intraoperative fill volumes and lower total number of sessions to achieve final volume. Submuscular reconstructions required a significantly higher tissue expander fill volume. Eight patients in the submuscular group required surgical revision of the breast and inframammary fold, compared with 4 in the ADM group; however, this difference was not significant. Patient satisfaction was equivalent between the 2 groups; however, it was higher in patients with bilateral reconstruction and lower among those who had received adjuvant radiation therapy. Satisfaction with nipple reconstruction was inversely proportional to time elapsed from the procedure to survey conduction. This is the first study to perform a head-to-head comparison on the basis of patient satisfaction, the results of which may be useful in preoperative planning and counseling. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31822f6765 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e31822f6765 [doi] PP - ppublish LG - English DP - 2013 Jan EZ - 2011/08/25 06:00 DA - 2013/05/25 06:00 DT - 2011/08/25 06:00 YR - 2013 ED - 20130523 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21862915 <301. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23274425 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bovill ES AU - Jansen L AU - Macadam S AU - Lennox P FA - Bovill, E S FA - Jansen, L FA - Macadam, S FA - Lennox, P TI - Reduction-pattern mastectomy: vascularity of the inferior dermal flap. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(4):587-8, 2013 Apr AS - J Plast Reconstr Aesthet Surg. 66(4):587-8, 2013 Apr NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 4 PG - 587-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Female MH - Humans MH - Indocyanine Green MH - *Mastectomy/mt [Methods] MH - Surgical Flaps/bs [Blood Supply] MH - *Surgical Flaps RN - IX6J1063HV (Indocyanine Green) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(12)00653-5 DO - https://dx.doi.org/10.1016/j.bjps.2012.11.022 PT - Letter ID - S1748-6815(12)00653-5 [pii] ID - 10.1016/j.bjps.2012.11.022 [doi] PP - ppublish PH - 2012/11/08 [received] PH - 2012/11/15 [accepted] LG - English EP - 20121227 DP - 2013 Apr EZ - 2013/01/01 06:00 DA - 2013/05/18 06:00 DT - 2013/01/01 06:00 YR - 2013 ED - 20130517 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23274425 <302. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23153519 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA AU - Dunavant C AU - Nocera N FA - Salzberg, C Andrew FA - Dunavant, Courtney FA - Nocera, Nadia IN - Salzberg, C Andrew. Division of Plastic Surgery, New York Medical College, NY, United States. asalzbergmd@yahoo.com TI - Immediate breast reconstruction using porcine acellular dermal matrix (StratticeTM): long-term outcomes and complications. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 66(3):323-8, 2013 Mar AS - J Plast Reconstr Aesthet Surg. 66(3):323-8, 2013 Mar NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 66 IP - 3 PG - 323-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis MH - Adult MH - *Breast Implants MH - Breast Neoplasms/pc [Prevention & Control] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Follow-Up Studies MH - Humans MH - Immunohistochemistry MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Care/mt [Methods] MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pa [Pathology] MH - Retrospective Studies MH - Risk Assessment MH - Time Factors MH - Treatment Outcome AB - BACKGROUND: There has been limited reported experience with the use of StratticeTM (LifeCell Corp., Branchburg, NJ), a porcine-derived acellular dermal matrix, in implant-based breast reconstruction. The purpose of this study is to evaluate our experience with this matrix. AB - METHODS: Patients who underwent immediate single-stage or two-stage implant-based breast reconstruction with the assistance of Strattice were included in this study. Patient charts were reviewed for indications for mastectomy, adjunctive radiotherapy use, implant or expander volume, length of follow-up period, and type and incidence of complications during the follow-up period. Biopsies of Strattice were taken for histological analyses. AB - RESULTS: A total of 105 reconstructions were performed in 54 patients: 77% were prophylactic and 23% were oncologic. All, but 4, reconstructions were single stage. Mean implant volume of single-stage reconstructions were 444.1 (range: 150-700 cc) and mean expander volume after completion of expansion was 400 (range: 350-450). Mean follow-up period was 41.3 months (range: 35.5-48.4 months). Total complication rate was 8.6%. Complications occurred in 9 breasts: implant loss or explantation (3.8%), infection (3.8%), skin breakdown or necrosis (2.9%), seroma (1.9%), implant exposure (1.0%), and delayed skin healing (1.0%). Histological analyses of implanted Strattice revealed a viable matrix with fibroblast infiltration and revascularization. AB - CONCLUSIONS: Over a mean 3.5-year follow-up period, low complication rates and good outcomes were observed with the use of Strattice that are comparable to those reported with human acellular dermal matrices. Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(12)00616-X DO - https://dx.doi.org/10.1016/j.bjps.2012.10.015 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - S1748-6815(12)00616-X [pii] ID - 10.1016/j.bjps.2012.10.015 [doi] PP - ppublish PH - 2012/04/26 [received] PH - 2012/09/18 [revised] PH - 2012/10/21 [accepted] LG - English EP - 20121113 DP - 2013 Mar EZ - 2012/11/17 06:00 DA - 2013/04/24 06:00 DT - 2012/11/17 06:00 YR - 2013 ED - 20130423 RD - 20130212 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23153519 <303. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23464695 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - DellaCroce FJ AU - Wolfe ET FA - DellaCroce, Frank J FA - Wolfe, Emily T IN - DellaCroce, Frank J. Department of Plastic Surgery, Center for Restorative Breast Surgery, 1717 Saint Charles Avenue, New Orleans, LA 70130, USA. drd@breastcenter.com TI - Breast reconstruction. [Review] SO - Surgical Clinics of North America. 93(2):445-54, 2013 Apr AS - Surg Clin North Am. 93(2):445-54, 2013 Apr NJ - The Surgical clinics of North America VO - 93 IP - 2 PG - 445-54 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - van, 0074243 IO - Surg. Clin. North Am. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis MH - Breast Implantation/is [Instrumentation] MH - Breast Implantation/mt [Methods] MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Contraindications MH - Female MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Postoperative Complications/et [Etiology] MH - Surgical Flaps/tr [Transplantation] AB - As diagnostic technology has progressed and the understanding of the disease process has evolved, the number of mastectomies performed in the United States has increased. Breast reconstructive techniques have commensurately become more sophisticated along the same timeline. The result is that those facing mastectomy have the potential to simultaneously retain physical beauty and wholeness. Only 33% of women who are otherwise candidates for immediate reconstruction at the time of mastectomy choose reconstruction. Patients generally have a high level of satisfaction with the option they choose, contributing to a feeling of overall recovery and physical and emotional wholeness. Copyright © 2013 Elsevier Inc. All rights reserved. ES - 1558-3171 IL - 0039-6109 DI - S0039-6109(12)00257-5 DO - https://dx.doi.org/10.1016/j.suc.2012.12.004 PT - Journal Article PT - Review ID - S0039-6109(12)00257-5 [pii] ID - 10.1016/j.suc.2012.12.004 [doi] PP - ppublish LG - English EP - 20130129 DP - 2013 Apr EZ - 2013/03/08 06:00 DA - 2013/04/23 06:00 DT - 2013/03/08 06:00 YR - 2013 ED - 20130422 RD - 20171116 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23464695 <304. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23446560 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Avashia YJ AU - Mohan R AU - Berhane C AU - Oeltjen JC FA - Avashia, Yash J FA - Mohan, Raja FA - Berhane, ChiChi FA - Oeltjen, John C IN - Avashia, Yash J. Division of Plastic and Reconstructive Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Health System, Miami, FL 33136, USA. TI - Postoperative antibiotic prophylaxis for implant-based breast reconstruction with acellular dermal matrix. SO - Plastic & Reconstructive Surgery. 131(3):453-61, 2013 Mar AS - Plast Reconstr Surg. 131(3):453-61, 2013 Mar NJ - Plastic and reconstructive surgery VO - 131 IP - 3 PG - 453-61 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Antibiotic Prophylaxis MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Postoperative Care MH - *Prosthesis-Related Infections/pc [Prevention & Control] MH - Retrospective Studies AB - BACKGROUND: The use of acellular dermal matrix in implant-based breast reconstruction has been described for improving inferolateral prosthesis coverage and support and inframammary fold reconstruction. Recommended guidelines for infection prophylaxis are the same as for any clean procedure-antibiotic administration only before surgery. Previous studies have demonstrated increased postoperative rates of infection and seroma associated with the use of acellular dermal matrix. The authors evaluated the impact of postoperative antibiotic prophylaxis on infection rates in postmastectomy expander-based breast reconstruction with acellular dermal matrix. AB - METHODS: : A retrospective study reviewed data of 96 patients who underwent either immediate or delayed expander-based breast reconstruction using AlloDerm allogenic acellular dermal matrix. Infection rates were analyzed after patients received postoperative antibiotic prophylaxis for at least 48 hours compared with those who received only perioperative antibiotics. AB - RESULTS: Infection rates for breast reconstructions with a postoperative antibiotic course were 7.9 and 3.2 percent. Patients with only perioperative antibiotics had an infection rate of 31.6 percent. Infections were defined by the endpoint of implant removal. Patient demographics, comorbidities, and intraoperative variables were recorded. Uncontrolled variables were time course between mastectomy and reconstruction, nodal dissection, operative history, and whether reconstruction was unilateral or bilateral. AB - CONCLUSIONS: This study demonstrates significant differences in the rate of infection between the groups of patients undergoing the first stage of two-stage implant-based breast reconstruction who received postoperative antibiotic prophylaxis and the group that received only perioperative antibiotics. This study suggests that the optimal duration of postoperative antibiotic prophylaxis is at least 48 hours. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31827c6d90 PT - Journal Article ID - 10.1097/PRS.0b013e31827c6d90 [doi] ID - 00006534-201303000-00004 [pii] PP - ppublish LG - English DP - 2013 Mar EZ - 2013/03/01 06:00 DA - 2013/04/23 06:00 DT - 2013/03/01 06:00 YR - 2013 ED - 20130422 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23446560 <305. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22616636 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Leyngold MM AU - Stutman RL AU - Khiabani KT AU - Shah H AU - Fong E AU - Ho CH AU - Zamboni WA FA - Leyngold, Mark M FA - Stutman, Ross L FA - Khiabani, Kayvan T FA - Shah, Himansu FA - Fong, Elvis FA - Ho, Chih-Hsiang FA - Zamboni, William A IN - Leyngold, Mark M. Division of Plastic Surgery, Department of Surgery, University of Nevada School of Medicine, Las Vegas, Nevada 89102-2227, USA. TI - Contributing variables to post mastectomy tissue expander infection. SO - Breast Journal. 18(4):351-6, 2012 Jul-Aug AS - Breast J. 18(4):351-6, 2012 Jul-Aug NJ - The breast journal VO - 18 IP - 4 PG - 351-6 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Logistic Models MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Mastectomy/ae [Adverse Effects] MH - Middle Aged MH - Necrosis MH - Odds Ratio MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Prosthesis-Related Infections/ep [Epidemiology] MH - *Prosthesis-Related Infections/et [Etiology] MH - Retrospective Studies MH - Smoking MH - Surgical Flaps/pa [Pathology] MH - Surgical Wound Infection/ep [Epidemiology] MH - *Surgical Wound Infection/et [Etiology] MH - *Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - Tissue expander breast reconstruction is a common post mastectomy breast procedure performed by plastic surgeons. The purpose of this study was to define the incidence of breast reconstruction prosthetic infection, relate patient characteristics with increased rate of infection, and analyze the influence of postoperative complications to expander/implant infection. A retrospective, single-institution chart review of 195 women with post mastectomy tissue expander/implant reconstructions performed from 2006 through 2008 was conducted. Total periprosthetic infection rate was calculated. Patient factors, operative technique, and noninfectious complications were analyzed and related to increased periprosthetic infection rate. A binary logistic regression model was fitted using periprosthetic infection as the dependent variable and 12 patient characteristics as independent variables, followed by a step-wise model for best fit with a limited number of independent variables. The overall periprosthetic infection rate per patient over the 2 year period was 5.1%. The incidence of periprosthetic infection per reconstructed breast was 3.2%. Odds ratio estimates indicated that the presence of cellulitis increased the odds of periprosthetic infection more than 200 times (p = <0.0001), and inpatient procedures increased the odds 16 times (p = 0.02). Other variables (i.e., age > 65, DM, flap necrosis, smoking, dehiscence, AlloDerm, etc) failed to reach statistical significance (p > 0.05). Postoperative breast cellulitis and inpatient status appear to be significant risk factors for increased periprosthetic infection. No significant increase in periprosthetic infection rate was noted with other variables in this model. Copyright © 2012 Wiley Periodicals, Inc. ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/j.1524-4741.2012.01253.x PT - Clinical Trial PT - Journal Article ID - 10.1111/j.1524-4741.2012.01253.x [doi] PP - ppublish LG - English EP - 20120523 DP - 2012 Jul-Aug EZ - 2012/05/24 06:00 DA - 2013/04/23 06:00 DT - 2012/05/24 06:00 YR - 2012 ED - 20130419 RD - 20120704 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22616636 <306. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21587037 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - de Blacam C AU - Momoh AO AU - Colakoglu S AU - Slavin SA AU - Tobias AM AU - Lee BT FA - de Blacam, Catherine FA - Momoh, Adeyiza O FA - Colakoglu, Salih FA - Slavin, Sumner A FA - Tobias, Adam M FA - Lee, Bernard T IN - de Blacam, Catherine. Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. TI - Cost analysis of implant-based breast reconstruction with acellular dermal matrix. SO - Annals of Plastic Surgery. 69(5):516-20, 2012 Nov AS - Ann Plast Surg. 69(5):516-20, 2012 Nov NJ - Annals of plastic surgery VO - 69 IP - 5 PG - 516-20 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis/ec [Economics] MH - *Breast Implantation/ec [Economics] MH - Breast Implantation/mt [Methods] MH - *Breast Implants/ec [Economics] MH - Costs and Cost Analysis MH - Female MH - Humans MH - Prospective Studies AB - A comparative cost analysis of breast reconstruction using acellular dermal matrix (ADM) and traditional tissue expander-/implant-based techniques was carried out. Medicare reimbursement costs were calculated for tissue expander/implant alone (TE/I), TE/I with ADM (TE/I + ADM), and single-stage implant (SSI) with ADM (SSI + ADM). The most expensive procedure at baseline was TE/I + ADM ($11,255.78), followed by TE/I alone ($10,934.18), and SSI + ADM ($5,423.02). Incorporating the probability of complications as derived from the published literature into the cost analysis resulted in an increase in the excess cost of ADM-based procedures (TE/I + ADM, $11,829.02; TE/I, $11,238.60; SSI + ADM, $5,909.83). Although SSI + ADM have the lowest cost, not all patients are suitable candidates for this type of procedure. With increasing focus on healthcare expenditure, it is important that plastic surgeons are aware of the cost implications of using ADM products. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e318217fb21 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/SAP.0b013e318217fb21 [doi] PP - ppublish LG - English DP - 2012 Nov EZ - 2011/05/19 06:00 DA - 2013/04/16 06:00 DT - 2011/05/19 06:00 YR - 2012 ED - 20130415 RD - 20121030 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21587037 <307. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23313013 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lotter O AU - Stahl S AU - Schiefer JL AU - Townley WA AU - Schaller HE AU - Jaminet P FA - Lotter, O FA - Stahl, S FA - Schiefer, J L FA - Townley, W A FA - Schaller, H-E FA - Jaminet, P IN - Lotter, O. Clinic for Plastic, Hand and Reconstructive Surgery, Burn and Trauma Center, Eberhard-Karls-University, Schnarrenbergstrasse 95, 72076 Tuebingen, Germany. oliver.lotter@freenet.de TI - A European comparison of reimbursement in breast reconstruction. SO - European Journal of Surgical Oncology. 39(3):273-8, 2013 Mar AS - Eur J Surg Oncol. 39(3):273-8, 2013 Mar NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 39 IP - 3 PG - 273-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - Acellular Dermis/ec [Economics] MH - Adult MH - Aged MH - Austria MH - Breast Diseases/ec [Economics] MH - Breast Diseases/su [Surgery] MH - Breast Implantation/ec [Economics] MH - Breast Neoplasms/ec [Economics] MH - Breast Neoplasms/su [Surgery] MH - Diagnosis-Related Groups MH - Fee-for-Service Plans/ec [Economics] MH - Female MH - Germany MH - Humans MH - Italy MH - Length of Stay MH - *Mammaplasty/ec [Economics] MH - Mammaplasty/mt [Methods] MH - Middle Aged MH - *Reimbursement Mechanisms/ec [Economics] MH - Reimbursement Mechanisms/sn [Statistics & Numerical Data] MH - Surgical Flaps MH - Sweden MH - United Kingdom AB - AIMS: Case payment mechanisms have become the principal means of remunerating hospitals in most developed countries. The purpose of this study was to make an international comparison of reimbursement for breast reconstructive surgery. AB - METHODS: We analysed remuneration for unilateral and bilateral female breast reconstruction (pedicled flaps, free flaps, alloplastic procedures) across five different European countries. National grouper software was used to identify Diagnosis Related Groups from which the proceeds were derived. AB - RESULTS: The mean reimbursement was 5593 for pedicled flaps, 9149 for free flaps and 4037 for implant-based reconstructions. The highest payments were in Sweden and the lowest in Italy. When adjusting payments by purchasing power parities, the relation among the countries did not change. The Austrian system makes a clear distinction between one-stage and two-stage delayed reconstructive interventions whereas reimbursement in other countries favoured a two-stage approach. Only one of five national reimbursement systems distinguishes between unilateral and bilateral reconstructions. AB - CONCLUSIONS: Across a spectrum of European countries, reimbursement for breast reconstruction was based on similar procedure-specific systems, although there was a wide variation in tariffs and consideration of other factors such as underlying diagnosis. As delivery of healthcare becomes more rationalised, there is a need for individualised reimbursement which correlates directly with activity. Drawing on the experience of different healthcare systems may lead to development of a more robust and fair system of reimbursement. Copyright © 2012. Published by Elsevier Ltd. ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(12)01381-9 DO - https://dx.doi.org/10.1016/j.ejso.2012.12.021 PT - Comparative Study PT - Journal Article ID - S0748-7983(12)01381-9 [pii] ID - 10.1016/j.ejso.2012.12.021 [doi] PP - ppublish PH - 2012/07/28 [received] PH - 2012/11/05 [revised] PH - 2012/12/20 [accepted] LG - English EP - 20130110 DP - 2013 Mar EZ - 2013/01/15 06:00 DA - 2013/04/06 06:00 DT - 2013/01/15 06:00 YR - 2013 ED - 20130405 RD - 20161125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23313013 <308. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23266307 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Johnson RK AU - Wright CK AU - Gandhi A AU - Charny MC AU - Barr L FA - Johnson, R K FA - Wright, C K FA - Gandhi, A FA - Charny, M C FA - Barr, L IN - Johnson, R K. Nightingale Centre and Genesis Breast Cancer Prevention Centre, University Hospital South Manchester, Wythenshawe, M23 9LT Manchester, UK. richard.johnson@uhsm.nhs.uk TI - Cost minimisation analysis of using acellular dermal matrix (StratticeTM) for breast reconstruction compared with standard techniques. SO - European Journal of Surgical Oncology. 39(3):242-7, 2013 Mar AS - Eur J Surg Oncol. 39(3):242-7, 2013 Mar NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 39 IP - 3 PG - 242-7 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - *Acellular Dermis/ec [Economics] MH - *Acellular Dermis/ut [Utilization] MH - Adult MH - Aged MH - Biocompatible Materials/ec [Economics] MH - Biocompatible Materials/tu [Therapeutic Use] MH - *Collagen/ec [Economics] MH - *Collagen/tu [Therapeutic Use] MH - Costs and Cost Analysis MH - Female MH - Humans MH - Length of Stay MH - *Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Modified Radical MH - Middle Aged MH - Operative Time MH - United Kingdom AB - BACKGROUND: We performed a cost analysis (using UK 2011/12 NHS tariffs as a proxy for cost) comparing immediate breast reconstruction using the new one-stage technique of acellular dermal matrix (StratticeTM) with implant versus the standard alternative techniques of tissue expander (TE)/implant as a two-stage procedure and latissimus dorsi (LD) flap reconstruction. AB - METHODS: Clinical report data were collected for operative time, length of stay, outpatient procedures, and number of elective and emergency admissions in our first consecutive 24 patients undergoing one-stage Strattice reconstruction. Total cost to the NHS based on tariff, assuming top-up payments to cover Strattice acquisition costs, was assessed and compared to the two historical control groups matched on key variables. AB - RESULTS: Eleven patients having unilateral Strattice reconstruction were compared to 10 having TE/implant reconstruction and 10 having LD flap and implant reconstruction. Thirteen patients having bilateral Strattice reconstruction were compared to 12 having bilateral TE/implant reconstruction. Total costs were: unilateral Strattice, 3685; unilateral TE, 4985; unilateral LD and implant, 6321; bilateral TE, 5478; and bilateral Strattice, 6771. AB - CONCLUSIONS: The cost analysis shows a financial advantage of using acellular dermal matrix (Strattice) in unilateral breast reconstruction versus alternative procedures. The reimbursement system in England (Payment by Results) is based on disease-related groups similar to that of many countries across Europe and tariffs are based on reported hospital costs, making this analysis of relevance in other countries. Copyright © 2013 Elsevier Ltd. All rights reserved. RN - 0 (Biocompatible Materials) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(12)01341-8 DO - https://dx.doi.org/10.1016/j.ejso.2012.12.002 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S0748-7983(12)01341-8 [pii] ID - 10.1016/j.ejso.2012.12.002 [doi] PP - ppublish PH - 2012/09/11 [received] PH - 2012/11/09 [revised] PH - 2012/12/06 [accepted] LG - English EP - 20121221 DP - 2013 Mar EZ - 2012/12/26 06:00 DA - 2013/04/06 06:00 DT - 2012/12/26 06:00 YR - 2013 ED - 20130405 RD - 20161125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23266307 <309. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23140923 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Semprini G AU - Cattin F AU - De Biasio F AU - Cedolini C AU - Parodi PC FA - Semprini, G FA - Cattin, F FA - De Biasio, F FA - Cedolini, C FA - Parodi, P C IN - Semprini, G. Plastic and Reconstructive Surgery Department, University of Udine, Udine, Italy. TI - The bovine pericardial patch in breast reconstruction: a case report. SO - Giornale di Chirurgia. 33(11-12):392-4, 2012 Nov-Dec AS - G Chir. 33(11-12):392-4, 2012 Nov-Dec NJ - Il Giornale di chirurgia VO - 33 IP - 11-12 PG - 392-4 PI - Journal available in: Print PI - Citation processed from: Print JC - avi, 9011768 IO - G Chir SB - Index Medicus CP - Italy MH - Acellular Dermis MH - Animals MH - Breast Implantation/mt [Methods] MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Cattle MH - *Collagen MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Pericardium/tr [Transplantation] MH - Reconstructive Surgical Procedures MH - Transplantation, Heterologous MH - Treatment Outcome MH - Wound Healing AB - In the last years there has been a growing demand of plastic surgery for soft tissue reconstruction. In response to this, many biological and synthetic devices have been produced, aiming to allow wide and complex body reshapings. Acellular dermal matrices are one of these devices, and are made of human or animal tissues made acellular after their sampling. They are used for cervical, breast and abdominal wall reconstruction. Tutopatch, generally used for face reconstruction or neurosurgery, is made of acellular bovine pericardium, and its high amount of collagen allows a fast tissue healing and a scaffold for the surrounding tissue regeneration. In our case report Tutopatch has been used in immediate breast reconstruction after mastectomy. This device has been used to close laterally the subpectoral pocket, allowing a bigger volume prosthesis to be placed We have not experienced particular postoperatory complications, and after 12 months of follow up we have found a valid functional and aesthetic result. We consider Tutopatch as a valid alternative to other acellular dermal matrices specifically designed for breast reconstruction. RN - 9007-34-5 (Collagen) IS - 0391-9005 IL - 0391-9005 PT - Case Reports PT - Journal Article ID - 5500 [pii] PP - ppublish LG - English DP - 2012 Nov-Dec EZ - 2012/11/13 06:00 DA - 2013/04/06 06:00 DT - 2012/11/13 06:00 YR - 2012 ED - 20130405 RD - 20121112 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23140923 <310. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23358028 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Peled AW AU - Esserman LJ FA - Peled, Anne Warren FA - Esserman, Laura J TI - Reply: The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy. CM - Comment on: Plast Reconstr Surg. 2013 Feb;131(2):278e-279e; PMID: 23358027 CM - Comment on: Plast Reconstr Surg. 2012 Jun;129(6):901e-908e; PMID: 22634688 SO - Plastic & Reconstructive Surgery. 131(2):279e, 2013 Feb AS - Plast Reconstr Surg. 131(2):279e, 2013 Feb NJ - Plastic and reconstructive surgery VO - 131 IP - 2 PG - 279e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Dermis/tr [Transplantation] MH - *Extracellular Matrix/tr [Transplantation] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - *Postoperative Care/mt [Methods] MH - *Skin Transplantation/mt [Methods] MH - *Tissue Expansion/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318278d739 PT - Comment PT - Letter ID - 10.1097/PRS.0b013e318278d739 [doi] ID - 00006534-201302000-00058 [pii] PP - ppublish LG - English DP - 2013 Feb EZ - 2013/01/30 06:00 DA - 2013/04/02 06:00 DT - 2013/01/30 06:00 YR - 2013 ED - 20130401 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23358028 <311. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23358027 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Perez-Garcia A AU - del Mar Luis-Hidalgo M AU - Perales-Puchalt A FA - Perez-Garcia, Alberto FA - del Mar Luis-Hidalgo, Maria FA - Perales-Puchalt, Alfredo TI - The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy. CM - Comment in: Plast Reconstr Surg. 2013 Feb;131(2):279e; PMID: 23358028 CM - Comment on: Plast Reconstr Surg. 2012 Jun;129(6):901e-908e; PMID: 22634688 SO - Plastic & Reconstructive Surgery. 131(2):278e-279e, 2013 Feb AS - Plast Reconstr Surg. 131(2):278e-279e, 2013 Feb NJ - Plastic and reconstructive surgery VO - 131 IP - 2 PG - 278e-279e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Dermis/tr [Transplantation] MH - *Extracellular Matrix/tr [Transplantation] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - *Postoperative Care/mt [Methods] MH - *Skin Transplantation/mt [Methods] MH - *Tissue Expansion/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318278d62e PT - Comment PT - Letter ID - 10.1097/PRS.0b013e318278d62e [doi] ID - 00006534-201302000-00057 [pii] PP - ppublish LG - English DP - 2013 Feb EZ - 2013/01/30 06:00 DA - 2013/04/02 06:00 DT - 2013/01/30 06:00 YR - 2013 ED - 20130401 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23358027 <312. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22990174 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Venturi ML AU - Mesbahi AN AU - Boehmler JH 4th AU - Marrogi AJ FA - Venturi, Mark L FA - Mesbahi, Ali N FA - Boehmler, James H 4th FA - Marrogi, Aizen J IN - Venturi, Mark L. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC, USA. TI - Evaluating sterile human acellular dermal matrix in immediate expander-based breast reconstruction: a multicenter, prospective, cohort study.[Erratum appears in Plast Reconstr Surg. 2013 Mar;131(3):669] SO - Plastic & Reconstructive Surgery. 131(1):9e-18e, 2013 Jan AS - Plast Reconstr Surg. 131(1):9e-18e, 2013 Jan NJ - Plastic and reconstructive surgery VO - 131 IP - 1 PG - 9e-18e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Breast/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - Cellulitis/ep [Epidemiology] MH - Cellulitis/et [Etiology] MH - Cohort Studies MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Necrosis/ep [Epidemiology] MH - Necrosis/et [Etiology] MH - Postoperative Complications/ep [Epidemiology] MH - Prospective Studies MH - Seroma/ep [Epidemiology] MH - Seroma/et [Etiology] MH - *Sterilization MH - Surgical Wound Infection/ep [Epidemiology] MH - *Tissue Expansion/mt [Methods] MH - Treatment Outcome AB - BACKGROUND: Human acellular dermal matrices have gained increasing use in immediate expander-based breast reconstruction. However, some studies suggest that these grafts may be associated with a higher incidence of infection and seroma. To evaluate complication rates after matrix-based breast reconstruction, the authors conducted a prospective, multicenter, cohort study to evaluate a sterile human acellular dermal matrix in immediate expander-based breast reconstruction, specifically, to determine whether it offered a more favorable risk profile with respect to infection and seroma. A secondary purpose was to determine whether the sterilization process affects graft incorporation. AB - METHODS: The authors performed 65 consecutive tissue expander-based breast reconstructions in a cohort of patients over a 1-year period using a single protocol. Sterile human matrix was used in all cases. The patients were evaluated for early complications (infection, seroma) and graft incorporation at the time of exchange or definitive reconstruction. Biopsies were performed in the first 20 reconstructions to provide histologic correlation of graft incorporation. AB - RESULTS: Complications occurred in three breasts (4.6 percent), including one case of cellulitis (1.5 percent) and two cases of partial mastectomy flap necrosis (3.0 percent) that required debridement. There were no seromas or explantations. The grafts were incorporated in all cases and verified histologically in the first 20 biopsies. AB - CONCLUSIONS: Sterile human acellular dermal matrix can offer reliable matrix incorporation and a low complication rate. Sterilization does not negatively impact incorporation of the graft. The infection and seroma rates in this prospective study compare favorably to those in previous studies with nonsterilized (aseptic) acellular dermal matrix. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182729d4f PT - Clinical Trial PT - Journal Article PT - Multicenter Study ID - 10.1097/PRS.0b013e3182729d4f [doi] PP - ppublish SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT01372917 SL - https://clinicaltrials.gov/search/term=NCT01372917 LG - English DP - 2013 Jan EZ - 2012/09/20 06:00 DA - 2013/02/26 06:00 DT - 2012/09/20 06:00 YR - 2013 ED - 20130225 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22990174 <313. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22097307 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Zeng A AU - Liu ZF AU - Qiao Q AU - Wang Z AU - Zhang HL AU - Long X AU - Si LB AU - Bai M FA - Zeng, Ang FA - Liu, Zhi-fei FA - Qiao, Qun FA - Wang, Zhi FA - Zhang, Hai-lin FA - Long, Xiao FA - Si, Lou-bin FA - Bai, Ming IN - Zeng, Ang. Plastic Surgery Department, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100032, China. TI - [Acellular cadaveric dermis-assisted immediate breast reconstruction: the preliminary experience]. [Chinese] SO - Zhonghua Zheng Xing Wai Ke Za Zhi. 27(4):250-3, 2011 Jul AS - Zhonghua Zheng Xing Wai Ke Za Zhi. 27(4):250-3, 2011 Jul NJ - Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery VO - 27 IP - 4 PG - 250-3 PI - Journal available in: Print PI - Citation processed from: Print JC - 100957850, dp9 IO - Zhonghua Zheng Xing Wai Ke Za Zhi SB - Index Medicus CP - China MH - *Acellular Dermis MH - Adult MH - Breast Implants MH - *Dermis/tr [Transplantation] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Skin Transplantation MH - Surgical Flaps MH - Tissue Expansion Devices MH - Treatment Outcome AB - OBJECTIVE: To investigate the feasibility and therapeutic effect of acellular cadaveric dermis (ACD)-assisted immediate breast reconstruction. AB - METHODS: From Sep. 2009 to May 2010, 10 cases received ACD-assisted immediate breast reconstruction. During the operation, the ACD was used to cover inferior and lateral portion of the implants in 2 cases and expanders in 8 cases. AB - RESULTS: The patients were followed up for an average period of 4 months with satisfactory breast appearance. The complications included infection in 2 cases and dehiscence in 2 cases. But no implant or expander was taken out. AB - CONCLUSIONS: The ACD-assisted immediate breast reconstruction is a technically simple procedure with minimal morbidity. Satisfactory clinical outcome can be achieved with appropriate candidates. IS - 1009-4598 IL - 1009-4598 PT - English Abstract PT - Journal Article PP - ppublish LG - Chinese DP - 2011 Jul EZ - 2011/11/22 06:00 DA - 2013/02/16 06:00 DT - 2011/11/22 06:00 YR - 2011 ED - 20130215 RD - 20111117 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22097307 <314. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22868313 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Brooke S AU - Mesa J AU - Uluer M AU - Michelotti B AU - Moyer K AU - Neves RI AU - Mackay D AU - Potochny J FA - Brooke, Sebastian FA - Mesa, John FA - Uluer, Mehmet FA - Michelotti, Brett FA - Moyer, Kurtis FA - Neves, Rogerio I FA - Mackay, Donald FA - Potochny, John IN - Brooke, Sebastian. Division of Plastic Surgery, The Pennsylvania State University, College of Medicine, Penn State Milton S. Hershey Medicine Center, Hershey, PA 17033-0850, USA. sbrooke@hmc.psu.edu TI - Complications in tissue expander breast reconstruction: a comparison of AlloDerm, DermaMatrix, and FlexHD acellular inferior pole dermal slings. SO - Annals of Plastic Surgery. 69(4):347-9, 2012 Oct AS - Ann Plast Surg. 69(4):347-9, 2012 Oct NJ - Annals of plastic surgery VO - 69 IP - 4 PG - 347-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - Collagen MH - Female MH - Humans MH - Incidence MH - Mastectomy MH - Middle Aged MH - Patient Readmission MH - Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/su [Surgery] MH - Reoperation MH - Retrospective Studies MH - *Skin Transplantation MH - *Tissue Expansion AB - Acellular dermal matrix (ADM) is frequently used in tissue expander breast reconstruction (TEBR) for coverage of the inferior pole. Several published studies have suggested increased rates of complications with the use of ADM. It is unknown, however, if the type of ADM used for TEBR impacts complication rates. The aim of this study is to compare 3 different types of ADM for TEBR in regard to clinically significant complications, specifically infection. We performed a retrospective analysis of primary breast cancer-related TEBR with or without ADM. Exclusion criteria consisted of prior major breast surgery, inadequate data, or loss to follow-up. Reconstructions were grouped by dermal sling type, AlloDerm, DermaMatrix (DM), FlexHD (FHD), or no ADM. Complications included cellulitis, abscess, seroma, expander leak or puncture, skin necrosis, wound dehiscence, or hematoma. Those requiring admission to hospital or reoperation were considered significant. Of 284 breasts reconstructed, 49 used AlloDerm, 110 used DM, 62 used FHD, and 64 used no ADM. The total complication rate with AlloDerm was 22% [95% confidence interval (CI), 11-34], with DM was 15% (95% CI, 8-21), and with FHD was 18% (95% CI, 8-28) (P=0.47). Infectious complication rates for AlloDerm, DM, and FHD were equal at 10% (P=0.97). The total complication rate of all ADM reconstructions as a grouped cohort was 17% compared to 11% without ADM (P=0.48). The overall incidence of infectious complications with ADM was 10% compared to 2% without ADM (P=0.09). There is no difference in the clinically significant overall complication rate or incidence of infection between AlloDerm, DM, and FHD. Isolating infectious complications, there is a trend toward increased incidence with ADM compared to reconstructions without. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31824b3d97 PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e31824b3d97 [doi] PP - ppublish LG - English DP - 2012 Oct EZ - 2012/08/08 06:00 DA - 2013/02/14 06:00 DT - 2012/08/08 06:00 YR - 2012 ED - 20130213 RD - 20120914 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22868313 <315. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22883962 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gandhi A AU - Barr L AU - Johnson R FA - Gandhi, A FA - Barr, L FA - Johnson, R TI - Bioprosthetics: changing the landscape for breast reconstruction?. [Review] SO - European Journal of Surgical Oncology. 39(1):24-5, 2013 Jan AS - Eur J Surg Oncol. 39(1):24-5, 2013 Jan NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 39 IP - 1 PG - 24-5 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - Acellular Dermis/ae [Adverse Effects] MH - *Acellular Dermis MH - Biocompatible Materials/ae [Adverse Effects] MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Surgical Flaps MH - Treatment Outcome RN - 0 (Biocompatible Materials) RN - 0 (Permacol) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(12)01030-X DO - https://dx.doi.org/10.1016/j.ejso.2012.07.109 PT - Editorial PT - Review ID - S0748-7983(12)01030-X [pii] ID - 10.1016/j.ejso.2012.07.109 [doi] PP - ppublish PH - 2012/06/21 [received] PH - 2012/07/19 [accepted] LG - English EP - 20120809 DP - 2013 Jan EZ - 2012/08/14 06:00 DA - 2013/02/05 06:00 DT - 2012/08/14 06:00 YR - 2013 ED - 20130204 RD - 20121211 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22883962 <316. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23362476 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Davila AA AU - Seth AK AU - Wang E AU - Hanwright P AU - Bilimoria K AU - Fine N AU - Kim JY FA - Davila, Armando A FA - Seth, Akhil K FA - Wang, Edward FA - Hanwright, Philip FA - Bilimoria, Karl FA - Fine, Neil FA - Kim, John Ys IN - Davila, Armando A. Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. TI - Human Acellular Dermis versus Submuscular Tissue Expander Breast Reconstruction: A Multivariate Analysis of Short-Term Complications. SO - Archives of Plastic Surgery. 40(1):19-27, 2013 Jan AS - Arch. plast. surg.. 40(1):19-27, 2013 Jan NJ - Archives of plastic surgery VO - 40 IP - 1 PG - 19-27 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556529 CP - Korea (South) KW - Alloderm; Breast implantation; Complications; Mammaplasty; Tissue expansion devices AB - BACKGROUND: Acellular dermal matrix (ADM) allografts and their putative benefits have been increasingly described in prosthesis based breast reconstruction. There have been a myriad of analyses outlining ADM complication profiles, but few large-scale, multi-institutional studies exploring these outcomes. In this study, complication rates of acellular dermis-assisted tissue expander breast reconstruction were compared with traditional submuscular methods by evaluation of the American College of Surgeon's National Surgical Quality Improvement Program (NSQIP) registry. AB - METHODS: Patients who underwent immediate tissue expander breast reconstruction from 2006-2010 were identified using surgical procedure codes. Two hundred forty tracked variables from over 250 participating sites were extracted for patients undergoing acellular dermis-assisted versus submuscular tissue expander reconstruction. Thirty-day postoperative outcomes and captured risk factors for complications were compared between the two groups. AB - RESULTS: A total of 9,159 patients underwent tissue expander breast reconstruction; 1,717 using acellular dermis and 7,442 with submuscular expander placement. Total complications and reconstruction related complications were similar in both cohorts (5.5% vs. 5.3%, P=0.68 and 4.7% vs. 4.3%, P=0.39, respectively). Multivariate logistic regression revealed body mass index and smoking as independent risk factors for reconstructive complications in both cohorts (P<0.01). AB - CONCLUSIONS: The NSQIP database provides large-scale, multi-institutional, independent outcomes for acellular dermis and submuscular breast reconstruction. Both thirty-day complication profiles and risk factors for post operative morbidity are similar between these two reconstructive approaches. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2013.40.1.19 PT - Journal Article ID - 10.5999/aps.2013.40.1.19 [doi] ID - PMC3556529 [pmc] PP - ppublish PH - 2012/09/19 [received] PH - 2012/10/23 [revised] PH - 2012/11/07 [accepted] LG - English EP - 20130114 DP - 2013 Jan EZ - 2013/01/31 06:00 DA - 2013/01/31 06:01 DT - 2013/01/31 06:00 YR - 2013 ED - 20130131 RD - 20161114 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23362476 <317. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23190846 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hajifathalian K AU - Zacharias DG AU - Gonzalez-Gonzalez LA AU - Goodman J FA - Hajifathalian, Kaveh FA - Zacharias, David G FA - Gonzalez-Gonzalez, Luis A FA - Goodman, Julie TI - A meta-analysis of human acellular dermis and submuscular tissue expander breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2012 Jan;129(1):28-41; PMID: 22186498 SO - Plastic & Reconstructive Surgery. 130(6):896e; author reply 896e-898e, 2012 Dec AS - Plast Reconstr Surg. 130(6):896e; author reply 896e-898e, 2012 Dec NJ - Plastic and reconstructive surgery VO - 130 IP - 6 PG - 896e; author reply 896e-898e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Implantation/mt [Methods] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Skin, Artificial MH - *Tissue Expansion Devices RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31826d9e2e PT - Comment PT - Letter ID - 10.1097/PRS.0b013e31826d9e2e [doi] ID - 00006534-201212000-00052 [pii] PP - ppublish LG - English DP - 2012 Dec EZ - 2012/11/30 06:00 DA - 2013/01/29 06:00 DT - 2012/11/30 06:00 YR - 2012 ED - 20130128 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23190846 <318. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23190802 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rinker B FA - Rinker, Brian IN - Rinker, Brian. Department of Surgery, Division of Plastic Surgery, University of Kentucky, Lexington, Ky 40536-0284, USA. brink2@email.uky.edu TI - The use of dermal autograft as an adjunct to breast reconstruction with tissue expanders. CM - Comment in: Plast Reconstr Surg. 2013 Jun;131(6):928e-929e; PMID: 23714828 CM - Comment in: Plast Reconstr Surg. 2013 Jun;131(6):926e-928e; PMID: 23714827 SO - Plastic & Reconstructive Surgery. 130(6):1179-85, 2012 Dec AS - Plast Reconstr Surg. 130(6):1179-85, 2012 Dec NJ - Plastic and reconstructive surgery VO - 130 IP - 6 PG - 1179-85 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - Carcinoma, Intraductal, Noninfiltrating/su [Surgery] MH - Carcinoma, Lobular/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/is [Instrumentation] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Patient Satisfaction MH - *Skin Transplantation/mt [Methods] MH - Tissue Expansion/is [Instrumentation] MH - *Tissue Expansion MH - Tissue Expansion Devices MH - Transplantation, Autologous AB - BACKGROUND: Acellular dermal matrices are commonly used in breast reconstruction but add cost to the procedure and have been associated with complications. Dermal autograft may represent a useful alternative to matrices. AB - METHODS: Sixteen patients (26 breasts) underwent breast reconstruction using tissue expanders and dermal autograft. Their ages ranged from 41 to 66 years (median, 51 years). Autografts were harvested by wide excision of preexisting abdominal scars. Demographic data, clinical history, and harvest and preparation time were recorded. The initial fill volume, number of expansions, and complications were recorded and compared with published data for acellular dermal matrix-assisted reconstruction. Patients rated their satisfaction with scar appearance on a seven-point scale. AB - RESULTS: Follow-up ranged from 6 to 16 months (mean, 10 months). Three patients were smokers. Mean body mass index was 30.5 (range, 19.1 to 48.8). Three patients received chemotherapy between reconstructive stages, and none required irradiation. The mean time of autograft harvest was 38 minutes, the mean initial fill was 190 cc, and the average number of expansions was 3.5. There were no implant losses. There were three minor complications (19 percent). Initial expander fill, number of expansions, and complication rate were equivalent to historical values for matrix-assisted breast reconstruction. Fourteen of 16 patients (88 percent) were "very satisfied" with their scars. AB - CONCLUSIONS: The use of dermal autograft in tissue expander breast reconstruction offers the advantages of acellular dermal matrix, without the associated expense. The technique adds minimally to the operative time and morbidity and is associated with a low complication rate. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31826d0f87 PT - Evaluation Studies PT - Journal Article ID - 10.1097/PRS.0b013e31826d0f87 [doi] ID - 00006534-201212000-00002 [pii] PP - ppublish LG - English DP - 2012 Dec EZ - 2012/11/30 06:00 DA - 2013/01/29 06:00 DT - 2012/11/30 06:00 YR - 2012 ED - 20130128 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23190802 <319. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096993 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA FA - Salzberg, C Andrew IN - Salzberg, C Andrew. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, 675 N. Saint Clair Street, Galter Suite 19-250, Chicago, Ill. 60611, USA. jokim@nmh.org TI - Focus on technique: one-stage implant-based breast reconstruction. [Review][Erratum appears in Plast Reconstr Surg. 2013 Mar;131(3):669] SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):95S-103S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):95S-103S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 95S-103S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Patient Selection MH - Pectoralis Muscles/su [Surgery] MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Suction MH - Surgical Flaps MH - Suture Techniques MH - *Tissue Expansion Devices AB - BACKGROUND: Direct-to-implant reconstruction with acellular dermal matrix has expanded the surgeon's repertoire and given the patient an opportunity to have a one-stage option after skin- or nipple-sparing mastectomy. The technique produces total implant coverage without the need for expansion, repeated operations, and delayed return of normal body image. AB - METHODS: In patients with adequate, good-quality mastectomy skin, a subpectoral pocket is created after mastectomy. The inferomedial pectoralis major muscle is elevated for implant placement. The acellular dermal matrix is sutured to the released inferior pole of the pectoralis muscle along its entire lower course and to the lateral mammary fold. The implant is introduced beneath the muscle-matrix layer, and the matrix is sutured to the inframammary fold at its desired position. Two suction drains are placed, one subpectorally and the other subcutaneously, through separate stab incisions, followed by skin closure. AB - RESULTS: Over a 10-year period, the author has performed this technique in 439 patients (790 breasts). Consistently low complication rates and good aesthetic outcomes have been obtained. Major complications, including implant loss (1.6 percent), skin necrosis requiring reoperation (1.3 percent), infection (1.1 percent), hematoma (0.6 percent), seroma (0.5 percent), and capsular contracture (0.5 percent), have remained at an incidence of less than 2 percent. AB - CONCLUSIONS: The author's 10-year results using acellular dermal matrix in direct-to-implant breast reconstructions demonstrate the effectiveness of the procedure, as well as its long-term safety and aesthetic benefits. Its success, however, relies on appropriate patient selection and specific intraoperative technique principles. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318262e1a1 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e318262e1a1 [doi] ID - 00006534-201211002-00015 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096993 <320. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096992 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL AU - Sher SR AU - Al-Attar A FA - Spear, Scott L FA - Sher, Sarah R FA - Al-Attar, Ali IN - Spear, Scott L. Department of Plastic Surgery, Georgetown University Hospital, 3800 Reservoir Road, N.W., Washington, DC 20007, USA. spears@gunet.georgetown.edu TI - Focus on technique: supporting the soft-tissue envelope in breast reconstruction. [Review] SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):89S-94S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):89S-94S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 89S-94S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - Esthetics MH - Evidence-Based Medicine MH - Female MH - Humans MH - *Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Muscle, Skeletal/su [Surgery] MH - Surgical Flaps MH - Suture Techniques MH - Tissue Expansion Devices MH - Treatment Outcome AB - Prosthetic-based breast reconstruction commonly involves device placement in either a total submuscular pocket or a partial subpectoral position for just superior pole coverage, with various possible strategies for inferior pole coverage. Historically, the pectoralis major muscle is managed either by suturing the muscle to the inferior flap or with marionette sutures; alternatively, the device is placed under total muscle/fascia coverage (under the pectoralis major, plus the serratus anterior and rectus abdominis muscles or fascia). For many plastic surgeons, acellular dermal matrix is now used instead to function as a sling or "hammock" supporting the periprosthetic pocket and thus covering the inferior pole of the device, attached to the pectoralis major muscle above and to the inframammary fold below. In addition to its added soft-tissue support in the inferior pole, acellular dermal matrix may help to stabilize the pectoralis major muscle along its inferolateral margin, create a well-defined inframammary fold, provide the opportunity to significantly increase intraoperative fill volume of the tissue expander, and reduce the incidence or severity of significant or symptomatic capsular contracture, particularly in a patient whose breast has been treated with radiation. In addition to its indications in primary breast reconstruction, acellular dermal matrix has been increasingly used in secondary revision reconstruction cases. It can be used to buttress capsulorrhapy and capsulotomy sites and it can be used to replace periprosthetic capsule following capsulectomy. While clinical experience is accruing for these indications, acellular dermal matrix continues to be used in primary and secondary breast reconstruction. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182625852 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e3182625852 [doi] ID - 00006534-201211002-00014 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096992 <321. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096991 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Namnoum JD FA - Namnoum, James D IN - Namnoum, James D. Atlanta Plastic Surgery, 975 Johnson Ferry Road, Atlanta, GA 30342, USA. TI - Discussion: The use of acellular dermal matrices in revisional breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):70S-85S; PMID: 23096989 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):86S-8S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):86S-8S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 86S-8S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - *Breast/re [Radiation Effects] MH - *Breast Implantation/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Reoperation/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f23dd PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e31825f23dd [doi] ID - 00006534-201211002-00013 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096991 <322. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096989 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Slavin SA AU - Lin SJ FA - Slavin, Sumner A FA - Lin, Samuel J IN - Slavin, Sumner A. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. TI - The use of acellular dermal matrices in revisional breast reconstruction. [Review] CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):86S-8S; PMID: 23096991 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):70S-85S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):70S-85S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 70S-85S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis/ec [Economics] MH - *Acellular Dermis MH - Animals MH - Breast/pa [Pathology] MH - *Breast/re [Radiation Effects] MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Neoplasms/su [Surgery] MH - Collagen/tu [Therapeutic Use] MH - Costs and Cost Analysis MH - Esthetics MH - Female MH - Follow-Up Studies MH - Foreign-Body Reaction/et [Etiology] MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/su [Surgery] MH - Implants, Experimental MH - Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/ae [Adverse Effects] MH - Meta-Analysis as Topic MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Reoperation/ec [Economics] MH - *Reoperation/mt [Methods] MH - Tissue Expansion Devices AB - BACKGROUND: The use of acellular dermal matrices in breast surgery has become popular in the last two decades, with a corresponding increase in experience and literature. The authors reviewed the literature and summarize key technical points regarding use of acellular dermal matrices in reconstructive breast surgery. AB - METHODS: Current applications have emphasized both primary and secondary breast reconstruction. Newer approaches focus on breast revisional surgery, especially when matrix material is used to correct deformities commonly arising after breast implant placement. In these situations, matrices have widened the indications and improved results by providing additional support to the lower pole, extending the pectoralis major muscle, and smoothing surface irregularities. Increased use of these products has also spurred our understanding of their biological properties of cell infiltration, tolerance, and inflammation. AB - RESULTS: Acquired deformities, such as symmastia, rippling, malposition, and lower pole bottoming out, that were previously difficult to treat are significantly improved by placement of acellular dermal matrix in the affected area. Although most of the available studies demonstrate short-term results (1 to 2 years of follow-up), our technical ability to treat complications after breast augmentation and mastopexy has expanded. Use of onlay grafts of matrix in areas of capsulectomy and capsulorrhaphy, placement of grafts of varying thickness for thinned tissues, and the wide variety of shapes and sizes of product available are reducing unfavorable aesthetic results. AB - CONCLUSIONS: Increased complications, including seroma formation, infection, wound dehiscence, and implant exposure, remain challenging problems. Long-term studies will be needed to prove the durability of acellular dermal matrices in breast revisional surgery. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f23ca PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e31825f23ca [doi] ID - 00006534-201211002-00012 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096989 <323. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096987 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - McCarthy CM AU - Lee CN AU - Halvorson EG AU - Riedel E AU - Pusic AL AU - Mehrara BJ AU - Disa JJ FA - McCarthy, Colleen M FA - Lee, Clara N FA - Halvorson, Eric G FA - Riedel, Elyn FA - Pusic, Andrea L FA - Mehrara, Babak J FA - Disa, Joseph J IN - McCarthy, Colleen M. Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. mccarthc@mskcc.org TI - The use of acellular dermal matrices in two-stage expander/implant reconstruction: a multicenter, blinded, randomized controlled trial. CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):67S-9S; PMID: 23096988 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):57S-66S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):57S-66S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 57S-66S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100590 OI - Source: NLM. NIHMS511507 SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Aged MH - Analgesia, Patient-Controlled MH - Antineoplastic Agents/ad [Administration & Dosage] MH - Antineoplastic Agents/tu [Therapeutic Use] MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/su [Surgery] MH - Chemotherapy, Adjuvant MH - *Collagen/tu [Therapeutic Use] MH - Combined Modality Therapy MH - Esthetics MH - Female MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - *Mammaplasty/mt [Methods] MH - Mammaplasty/px [Psychology] MH - Mastectomy MH - Middle Aged MH - Narcotics/ad [Administration & Dosage] MH - Narcotics/tu [Therapeutic Use] MH - Pain Measurement MH - Pain, Postoperative/dt [Drug Therapy] MH - Pain, Postoperative/ep [Epidemiology] MH - *Pain, Postoperative/pc [Prevention & Control] MH - Patient Satisfaction MH - Quality of Life MH - Single-Blind Method MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Current efficacy data supporting the routine use of acellular dermal matrices in postmastectomy tissue expander/implant reconstruction are limited. A multicenter, blinded, randomized controlled study was designed to evaluate the effectiveness of acellular dermal matrix in the setting of tissue expander/implant reconstruction. The primary objective of the study was to determine whether the use of matrix would decrease patient-reported postoperative pain. The secondary objective was to determine whether its use would accelerate the rate of postoperative expansion. AB - METHODS: The randomized controlled trial was conducted at two U.S. centers from 2008 to 2011. Immediately following mastectomy, all patients were randomized to one of two treatment arms: (1) acellular dermal matrix-assisted, tissue expander/implant reconstruction; and (2) submuscular tissue expander/implant placement. All patients were blinded to their treatment arm. AB - RESULTS: One hundred eight consented to participate; 38 were excluded prior to randomization. In total, 70 patients were randomized. There were no differences seen in immediate postoperative pain (p = 0.19) or pain during the expansion phase (p = 0.65) between treatment arms. There was similarly no difference in postoperative narcotic use (p = 0.38). The rate of postoperative expansion did not differ between groups (p = 0.83). AB - CONCLUSIONS: The results suggest that the use of acellular dermal matrix in the setting of tissue expander/implant reconstruction neither reduces postoperative pain nor accelerates the rate of postoperative expansion. An examination of its efficacy in improving long-term outcomes following tissue expander/implant reconstruction is warranted. RN - 0 (Alloderm) RN - 0 (Antineoplastic Agents) RN - 0 (Narcotics) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f05b4 PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural ID - 10.1097/PRS.0b013e31825f05b4 [doi] ID - 00006534-201211002-00010 [pii] ID - PMC4100590 [pmc] ID - NIHMS511507 [mid] PP - ppublish SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT00639106 SL - https://clinicaltrials.gov/search/term=NCT00639106 GI - No: K07 CA154850 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: KL2 RR025746 Organization: (RR) *NCRR NIH HHS* Country: United States GI - No: 1KL2RR025746-01 Organization: (RR) *NCRR NIH HHS* Country: United States LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096987 <324. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096988 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Georgetown University Hospital, 3800 Reservoir Road, N.W., Washington, DC 20007, USA. drnahabedian@aol.com TI - Discussion: The use of acellular dermal matrices in two-stage expander/implant reconstruction: a multicenter, blinded, randomized controlled trial. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):57S-66S; PMID: 23096987 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):67S-9S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):67S-9S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 67S-9S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Pain, Postoperative/pc [Prevention & Control] MH - *Tissue Expansion Devices RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f020e PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e31825f020e [doi] ID - 00006534-201211002-00011 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096988 <325. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096986 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gabriel A AU - Maxwell GP FA - Gabriel, Allen FA - Maxwell, G Patrick IN - Gabriel, Allen. Department of Plastic Surgery, Loma Linda University Medical Center, 11175 Campus Street, Suite 21126, Loma Linda, CA 92350, USA. gabrielallen@yahoo.com TI - Discussion: Acellular dermal matrices in primary breast reconstruction: principles, concepts, and indications. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):44S-53S; PMID: 23096984 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):54S-6S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):54S-6S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 54S-6S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f222c PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e31825f222c [doi] ID - 00006534-201211002-00009 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096986 <326. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096984 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University, 3800 Reservoir Road, N.W., Washington, DC 20007, USA. drnahabedian@aol.com TI - Acellular dermal matrices in primary breast reconstruction: principles, concepts, and indications. [Review] CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):54S-6S; PMID: 23096986 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):44S-53S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):44S-53S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 44S-53S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Combined Modality Therapy MH - Esthetics MH - Female MH - Fibrosis/pc [Prevention & Control] MH - Foreign-Body Reaction/et [Etiology] MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Neovascularization, Physiologic MH - Obesity, Morbid/co [Complications] MH - Pectoralis Muscles/su [Surgery] MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Radiotherapy, Adjuvant MH - Smoking/ae [Adverse Effects] MH - Sodium Chloride/ad [Administration & Dosage] MH - Tissue Expansion Devices AB - Prosthetic breast reconstruction using acellular dermal matrix is currently used by many plastic surgeons. As our understanding of these matrices expands, our results and outcomes are becoming more reproducible and predictable. As with most new technologies, there is a learning curve associated with using acellular dermal matrix. There are principles and concepts that should be heeded when considering their use. The purpose of this article is to review some of the important principles and concepts to improve our understanding of how these matrices perform and what can be expected of them. RN - 451W47IQ8X (Sodium Chloride) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f2215 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e31825f2215 [doi] ID - 00006534-201211002-00008 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096984 <327. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096982 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Clemens MW AU - Kronowitz SJ FA - Clemens, Mark W FA - Kronowitz, Steven J IN - Clemens, Mark W. Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA. TI - Acellular dermal matrix in irradiated tissue expander/implant-based breast reconstruction: evidence-based review. [Review] SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):27S-34S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):27S-34S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 27S-34S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/re [Radiation Effects] MH - Animals MH - Breast/pa [Pathology] MH - *Breast/re [Radiation Effects] MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Clinical Trials as Topic MH - Combined Modality Therapy MH - Esthetics MH - Evaluation Studies as Topic MH - Evidence-Based Medicine MH - Female MH - Humans MH - *Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - Implants, Experimental MH - *Mammaplasty/mt [Methods] MH - Mastectomy, Segmental MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - *Radiotherapy, Adjuvant/ae [Adverse Effects] MH - Sodium Chloride/ad [Administration & Dosage] MH - Suction MH - Surgical Wound Infection/et [Etiology] MH - Surgical Wound Infection/pc [Prevention & Control] MH - *Tissue Expansion Devices AB - BACKGROUND: The benefits of acellular dermal matrix for breast reconstruction have been well described. However, its clinical impact for breast reconstruction in the setting of radiation therapy has not been well reported. AB - METHODS: The MEDLINE and EMBASE databases were reviewed for articles published between January of 2005 and February of 2012 on breast reconstruction using acellular dermal matrix in the setting of radiation therapy. The authors also reviewed their institutional experience of consecutive patients who met these criteria between January of 2008 and October of 2011. AB - RESULTS: Thirteen articles were identified for review: three animal studies on acellular dermal matrix and 10 with level III evidence of its use in humans. The 10 clinical studies included 246 irradiated patients. The M. D. Anderson experience included 30 irradiated acellular dermal matrix patients for a total of 276 irradiated patients evaluated in this review. Use of acellular dermal matrix in implant-based breast reconstruction in the setting of radiation therapy did not predispose to higher infection or overall complication rates or prevent bioprosthetic mesh incorporation. However, the rate of mesh incorporation may be slowed. Its use allowed for increased intraoperative saline fill volumes, which improved aesthetic outcomes and allowed patients to awake from surgery with a formed breast. AB - CONCLUSIONS: Use of acellular dermal matrix for implant-based breast reconstruction does not appear to increase or decrease the risk of complications, but it might provide psychological and aesthetic benefits. Multicenter or single-center randomized controlled trials that provide high-quality, level I evidence are warranted. RN - 451W47IQ8X (Sodium Chloride) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318265f690 PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review ID - 10.1097/PRS.0b013e318265f690 [doi] ID - 00006534-201211002-00006 [pii] PP - ppublish GI - No: P30 CA016672 Organization: (CA) *NCI NIH HHS* Country: United States GI - No: CA016672 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20161019 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096982 <328. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096967 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fosnot J AU - Serletti JM FA - Fosnot, Joshua FA - Serletti, Joseph M IN - Fosnot, Joshua. Division of Plastic Surgery, University of Pennsylvania Health System, 10 Penn Tower, 3400 Spruce Street, Philadelphia, PA 19104, USA. TI - Discussion: Complications of acellular dermal matrices in breast surgery. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):159S-72S; PMID: 23096966 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):173S-4S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):173S-4S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 173S-4S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Postoperative Complications/et [Etiology] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318262e2ec PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318262e2ec [doi] ID - 00006534-201211002-00025 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096967 <329. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096966 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Israeli R FA - Israeli, Ron IN - Israeli, Ron. Department of Surgery, Division of Plastic Surgery, Hofstra University School of Medicine in Partnership with the North Shore-LIJ Health System, Great Neck, NY 11021, USA. risraeli@nybra.com TI - Complications of acellular dermal matrices in breast surgery. [Review] CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):173S-4S; PMID: 23096967 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):159S-72S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):159S-72S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 159S-72S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ae [Adverse Effects] MH - Breast/pa [Pathology] MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Combined Modality Therapy MH - Esthetics MH - Female MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Meta-Analysis as Topic MH - Necrosis MH - Nipples/su [Surgery] MH - Patient Selection MH - Pectoralis Muscles/su [Surgery] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Radiotherapy, Adjuvant/ae [Adverse Effects] MH - Retrospective Studies MH - Risk Factors MH - Seroma/et [Etiology] MH - Suction MH - Surgical Flaps MH - Surgical Wound Infection/et [Etiology] MH - Suture Techniques MH - Tissue Expansion Devices AB - Acellular dermal matrices have been used in breast surgery for a decade. They are widely used in implant-based breast reconstruction to provide coverage of the inferolateral aspects of the prosthesis. Numerous benefits have been reported with this approach including improved fold control, better support and control of the implant pocket with concomitant reduced risk of malposition, and improved lower pole expansion. Seroma, infection, mastectomy skin necrosis, and expander/implant loss are the most commonly reported complications with this approach, and the incidences vary widely among studies. Patient selection and adherence to established intraoperative technique principles related to acellular dermal matrix use are both critical to minimizing the risk of complications. Acellular dermal matrices are also being used in aesthetic breast surgery, revision breast surgery, and nipple reconstruction, but clinical experience is limited. This article reviews the complications associated with the use of matrices in breast surgery from the published literature. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182634e62 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e3182634e62 [doi] ID - 00006534-201211002-00024 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096966 <330. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096965 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hammond DC FA - Hammond, Dennis C IN - Hammond, Dennis C. Partners in Plastic Surgery, Grand Rapids, MI, USA. hammonddc@aol.com TI - Discussion: Acellular dermal matrices in secondary aesthetic breast surgery: indications, techniques, and outcomes. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):142S-56S; PMID: 23096964 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):157S-8S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):157S-8S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 157S-8S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Animals MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318260e34a PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318260e34a [doi] ID - 00006534-201211002-00023 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096965 <331. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096964 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bengtson B FA - Bengtson, Bradley IN - Bengtson, Bradley. Bengtson Center for Aesthetics and Plastic Surgery and Michigan State University School of Medicine, MI, USA. drb@bengtsoncenter.com TI - Acellular dermal matrices in secondary aesthetic breast surgery: indications, techniques, and outcomes. CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):157S-8S; PMID: 23096965 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):142S-56S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):142S-56S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 142S-56S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Acellular Dermis/ec [Economics] MH - *Acellular Dermis MH - Animals MH - Biomechanical Phenomena MH - Breast Implantation/ec [Economics] MH - *Breast Implantation/mt [Methods] MH - Collagen/ad [Administration & Dosage] MH - Collagen/tu [Therapeutic Use] MH - Costs and Cost Analysis MH - Esthetics MH - Female MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pa [Pathology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - Implant Capsular Contracture/su [Surgery] MH - Implants, Experimental MH - *Mammaplasty/mt [Methods] MH - Pectoralis Muscles/su [Surgery] MH - Postoperative Care MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Reoperation/mt [Methods] MH - Skin Aging MH - Suture Techniques MH - Tissue Expansion Devices AB - Acellular dermal matrices are integrally involved in the majority of expander-implant reconstructions and complex hernia repairs today, and they are now making their way into secondary aesthetic breast surgery. The number of revisional breast surgery cases has continued to increase as the materials and repair techniques have improved. The aesthetic outcome bar is constantly being raised, and the complexity of patient deformities often requires additional tissues to achieve a successful repair. The most common complications in breast augmentation are reviewed, along with indications and some current repair techniques, general principles, and specific caveats to help plastic surgeons deal with these complex and challenging patient problems utilizing acellular dermal matrices. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318261ef9c PT - Journal Article ID - 10.1097/PRS.0b013e318261ef9c [doi] ID - 00006534-201211002-00022 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096964 <332. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096963 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bengtson B FA - Bengtson, Bradley IN - Bengtson, Bradley. Bengtson Center for Aesthetics and Plastic Surgery and Michigan State University School of Medicine, Grand Rapids, MI, USA. drb@bengtsoncenter.com TI - Discussion: Use of dermal matrix to prevent capsular contracture in aesthetic breast surgery. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):126S-36S; PMID: 23096962 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):137S-41S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):137S-41S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 137S-41S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182639104 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e3182639104 [doi] ID - 00006534-201211002-00021 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096963 <333. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096962 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hester TR Jr AU - Ghazi BH AU - Moyer HR AU - Nahai FR AU - Wilton M AU - Stokes L FA - Hester, T Roderick Jr FA - Ghazi, Bahair H FA - Moyer, Hunter R FA - Nahai, Farzad R FA - Wilton, Melissa FA - Stokes, Lou IN - Hester, T Roderick Jr. Paces Plastic Surgery, 3200 Downwood Circle, Suite 640, Atlanta, GA 30327, USA. viper09.rh@gmail.com TI - Use of dermal matrix to prevent capsular contracture in aesthetic breast surgery. CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):137S-41S; PMID: 23096963 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):126S-36S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):126S-36S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 126S-36S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Coated Materials, Biocompatible MH - Collagen/ad [Administration & Dosage] MH - *Collagen/tu [Therapeutic Use] MH - Device Removal MH - Equipment Design MH - Esthetics MH - Female MH - Foreign-Body Reaction/et [Etiology] MH - Foreign-Body Reaction/pa [Pathology] MH - Foreign-Body Reaction/pc [Prevention & Control] MH - Hematoma/et [Etiology] MH - Hematoma/su [Surgery] MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - Implant Capsular Contracture/pa [Pathology] MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty/mt [Methods] MH - Pectoralis Muscles/su [Surgery] MH - Polyurethanes MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Postoperative Complications/su [Surgery] MH - Retrospective Studies MH - Seroma/et [Etiology] MH - Seroma/su [Surgery] MH - Suture Techniques MH - Tissue Expansion Devices MH - Treatment Failure AB - Capsular contracture remains a challenging complication of implant-based aesthetic breast surgery despite improvements in implant design. The lowering of capsular contracture rates noted with the past use of polyurethane foam-covered implants has increased awareness of the importance of the biologic response at the interface between the implant surface and breast tissue. Emerging evidence indicates that much like the polyurethane foam, acellular dermal matrices alter the biologic response at the surface interface, resulting in a more vascular and less constrictive pattern of collagen deposition. This study reports on the authors' clinical experience using Strattice Reconstructive Tissue Matrix (LifeCell Corporation, Branchburg, N.J.) for the treatment of capsular contracture in patients with established capsules and for prevention in patients undergoing primary augmentation or augmentation/mastopexy. Of 80 patients (154 breasts) in whom Strattice was used, clinically significant contracture (Baker grade III/IV) occurred in three breasts (3.75 percent), all of which were in the treatment of previous contracture group. In addition, the authors noted two seromas requiring implant removal (both patients developed capsules, as mentioned above) and two hematomas requiring revision, for an overall failure rate of 6.25 percent for Strattice-assisted surgery. The data confirm that the use of Strattice significantly lowers the incidence of capsular contracture in the first 3.5 years after implant placement. RN - 0 (Coated Materials, Biocompatible) RN - 0 (Polyurethanes) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182605d18 PT - Evaluation Studies PT - Journal Article ID - 10.1097/PRS.0b013e3182605d18 [doi] ID - 00006534-201211002-00020 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096962 <334. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096961 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Zienowicz RJ FA - Zienowicz, Richard J IN - Zienowicz, Richard J. Department of Plastic Surgery, Brown University School of Medicine, Corliss Landing, 10 Bridge Street, Providence, RI 02905, USA. rzienowicz@lifespan.org TI - Discussion: The role of acellular dermal matrices in capsular contracture: a review of the evidence. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):118S-24S; PMID: 23096960 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):125S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):125S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 125S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - *Tissue Expansion Devices ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318263ad1e PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318263ad1e [doi] ID - 00006534-201211002-00019 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096961 <335. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096960 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Basu CB AU - Jeffers L FA - Basu, C Bob FA - Jeffers, Lynn IN - Basu, C Bob. Private Practice, Houston, Texas, USA. drbasu@basuplasticsurgery.com TI - The role of acellular dermal matrices in capsular contracture: a review of the evidence. [Review] CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):125S; PMID: 23096961 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):118S-24S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):118S-24S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 118S-24S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Clinical Trials as Topic MH - Collagen/tu [Therapeutic Use] MH - Esthetics MH - Female MH - Fibrosis MH - Follow-Up Studies MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pa [Pathology] MH - *Implant Capsular Contracture/pc [Prevention & Control] MH - Implant Capsular Contracture/su [Surgery] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Pectoralis Muscles/su [Surgery] MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Radiotherapy, Adjuvant/ae [Adverse Effects] MH - Retrospective Studies MH - Surgical Flaps MH - *Tissue Expansion Devices AB - Despite advances in breast implant surgery, capsular contracture remains a challenging sequela of reconstructive and cosmetic breast implant surgery. Although there are established modalities for treatment, most recently, acellular dermal matrix products have been suggested to have a role in preventing or diminishing the pathologic process of capsular contracture. In this article, the author presents a review of the literature to highlight the level of evidence on the role of acellular dermal matrices in the treatment of capsular contracture. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318262df58 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e318262df58 [doi] ID - 00006534-201211002-00018 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096960 <336. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096959 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cordeiro PG FA - Cordeiro, Peter G IN - Cordeiro, Peter G. Plastic and Reconstructive Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. TI - Discussion: Focus on technique: two-stage implant-based breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):104S-15S; PMID: 23096958 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):116S-7S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):116S-7S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 116S-7S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Tissue Expansion Devices ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f2549 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e31825f2549 [doi] ID - 00006534-201211002-00017 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096959 <337. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23096958 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kim JY AU - Connor CM FA - Kim, John Y S FA - Connor, Caitlin M IN - Kim, John Y S. Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, 675 N. Saint Clair Street, Galter Suite 19-250, Chicago, IL 60611, USA. jokim@nmh.org TI - Focus on technique: two-stage implant-based breast reconstruction. [Review] CM - Comment in: Plast Reconstr Surg. 2012 Nov;130(5 Suppl 2):116S-7S; PMID: 23096959 SO - Plastic & Reconstructive Surgery. 130(5 Suppl 2):104S-15S, 2012 Nov AS - Plast Reconstr Surg. 130(5 Suppl 2):104S-15S, 2012 Nov NJ - Plastic and reconstructive surgery VO - 130 IP - 5 Suppl 2 PG - 104S-15S PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - Equipment Design MH - Esthetics MH - Evidence-Based Medicine MH - Female MH - Forecasting MH - Humans MH - Implant Capsular Contracture/et [Etiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Nipples/su [Surgery] MH - Patient Selection MH - Pectoralis Muscles/su [Surgery] MH - Postoperative Complications/et [Etiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Preoperative Care/mt [Methods] MH - Retrospective Studies MH - Risk MH - Surgical Flaps MH - Suture Techniques MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Acellular dermal matrix has become a frequent adjunct to traditional expander-based breast reconstruction. Its putative advantages include improved positioning of the prosthesis, better definition of the inframammary fold, amelioration of potential contracture, and overall enhancement of cosmesis. Concomitantly, there may be an increased risk of seroma, infection, and reconstructive failure. AB - METHODS: A thorough review of the techniques and outcomes of two-stage acellular dermis-assisted breast reconstruction was performed. AB - RESULTS: Key technical aspects of two-stage acellular dermal matrix-based reconstruction are presented. Indications, techniques of handling and inset, and select strategies to avoid and manage common complications are discussed. Evidence-based outcomes are reviewed. AB - CONCLUSIONS: Acellular dermal matrix-based two-stage reconstruction continues to evolve as a viable option in breast reconstruction. Future studies will better delineate the risks and benefits of the technique. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31825f2538 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e31825f2538 [doi] ID - 00006534-201211002-00016 [pii] PP - ppublish LG - English DP - 2012 Nov EZ - 2012/11/01 06:00 DA - 2013/01/25 06:00 DT - 2012/10/26 06:00 YR - 2012 ED - 20130124 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23096958 <338. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23308305 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Nguyen KT AU - Mioton LM AU - Smetona JT AU - Seth AK AU - Kim JY FA - Nguyen, Khang T FA - Mioton, Lauren M FA - Smetona, John T FA - Seth, Akhil K FA - Kim, John Y IN - Nguyen, Khang T. Northwestern University Feinberg School of Medicine, Chicago, Ill. TI - Esthetic Outcomes of ADM-Assisted Expander-Implant Breast Reconstruction. SO - Eplasty [Electronic Resource]. 12:e58, 2012 AS - Eplasty. 12:e58, 2012 NJ - Eplasty VO - 12 PG - e58 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528352 CP - United States AB - OBJECTIVE: Adjunct acellular dermal matrices (ADM) are thought to improve esthetic outcomes of breast reconstruction but the existing evidence is largely anecdotal. In this study, we provide comparative data on esthetic outcomes of expander-implant breast reconstruction with and without ADM. AB - METHODS: Chart review was performed on a consecutive series of expander-implant reconstructions by the senior author. Demographic, oncologic, surgical, and photographic data were obtained for each patient. Photographic data were scored using a 3-point (0-1-2) breast-specific esthetic scale by 3 blinded, independent reviewers not involved in patient care. AB - RESULTS: ADM-assisted breast reconstructions had significantly higher scores than the non-ADM reconstructions for breast mound volume (1.38 vs 1.11; P = .0102), breast mound placement (1.57 vs 1.39; P = .0217), and the inframammary fold (1.39 vs 1.23; P = .0458). AB - CONCLUSIONS: ADM may improve breast volume, placement, and inframammary fold definition. These specific findings may help plastic surgeons better utilize ADM to improve outcomes for breast reconstruction. ES - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC3528352 [pmc] PP - ppublish LG - English EP - 20121219 DP - 2012 EZ - 2013/01/12 06:00 DA - 2013/01/12 06:01 DT - 2013/01/12 06:00 YR - 2012 ED - 20130114 RD - 20140731 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23308305 <339. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22981749 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Dieterich M AU - Reimer T AU - Dieterich H AU - Stubert J AU - Gerber B FA - Dieterich, M FA - Reimer, T FA - Dieterich, H FA - Stubert, J FA - Gerber, B IN - Dieterich, M. Department of Obstetrics and Gynecology, Breast Unit, University of Rostock, Interdisciplinary Breast Center, Suedring 81, 18059 Rostock, Germany. max.dieterich@uni-rostock.de TI - A short-term follow-up of implant based breast reconstruction using a titanium-coated polypropylene mesh (TiLoop() Bra). SO - European Journal of Surgical Oncology. 38(12):1225-30, 2012 Dec AS - Eur J Surg Oncol. 38(12):1225-30, 2012 Dec NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 38 IP - 12 PG - 1225-30 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol SB - Index Medicus CP - England MH - Adolescent MH - Adult MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Coated Materials, Biocompatible MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - *Polypropylenes MH - Prosthesis Design MH - Retrospective Studies MH - *Surgical Mesh MH - Time Factors MH - *Titanium MH - Treatment Outcome MH - Young Adult AB - INTRODUCTION: A new approach for implant based breast reconstruction (IBBR) is the use of a titanium-coated polypropylene mesh (TCPM) as an alternative to acellular dermal matrix (ADM). This TCPM has a good biocompatibility and can be used similarly to ADM. The aim of this study is to discuss indications, limitations and complications of TCPM in IBBR. AB - METHODS: A retrospective analysis of 42 patients undergoing immediate or delayed IBBR using a TCPM was performed. Primary endpoints were incidence of infection and expander/implant with mesh removal due to infected fluid collection or extrusion. AB - RESULTS: In two patients, mild hematoma, seroma or infection occurred. Skin necrosis or capsular contraction was observed in one patient. Mesh explantation was needed in 3 cases. These events were higher among the first cases and in patients with postoperative skin infection (p = 0.003). AB - CONCLUSION: In selected patients with adequate soft tissue cover TCPM seems to be a helpful tool for implant stabilization in terms of lateral stabilization and fixation of the musculus pectoralis major. In comparison to ADM, TCPM is cheaper and initial results are promising, but further follow-up data are necessary. In patients with poor soft tissue cover ADM should be used. Copyright © 2012 Elsevier Ltd. All rights reserved. RN - 0 (Coated Materials, Biocompatible) RN - 0 (Polypropylenes) RN - D1JT611TNE (Titanium) ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(12)01235-8 DO - https://dx.doi.org/10.1016/j.ejso.2012.08.026 PT - Comparative Study PT - Journal Article PT - Multicenter Study ID - S0748-7983(12)01235-8 [pii] ID - 10.1016/j.ejso.2012.08.026 [doi] PP - ppublish PH - 2012/06/18 [received] PH - 2012/08/09 [revised] PH - 2012/08/23 [accepted] LG - English EP - 20120913 DP - 2012 Dec EZ - 2012/09/18 06:00 DA - 2013/01/09 06:00 DT - 2012/09/18 06:00 YR - 2012 ED - 20130108 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22981749 <340. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22929292 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Larcher L AU - Riml S AU - Campisi C AU - Lazzeri D AU - Huemer GM FA - Larcher, Lorenz FA - Riml, Stefan FA - Campisi, Corrado FA - Lazzeri, Davide FA - Huemer, Georg M IN - Larcher, Lorenz. Section of Plastic, Aesthetic, and Reconstructive Surgery General Hospital Linz Linz, Austria. TI - Acellular dermis-assisted prosthetic breast reconstruction: mission accomplished?. CM - Comment on: Plast Reconstr Surg. 2011 Dec;128(6):1162-9; PMID: 22094735 SO - Plastic & Reconstructive Surgery. 130(3):499e-500e, 2012 Sep AS - Plast Reconstr Surg. 130(3):499e-500e, 2012 Sep NJ - Plastic and reconstructive surgery VO - 130 IP - 3 PG - 499e-500e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Biocompatible Materials MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Postoperative Complications/et [Etiology] RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Comment PT - Letter ID - 10.1097/PRS.0b013e31825dc5d4 [doi] ID - 00006534-201209000-00065 [pii] PP - ppublish LG - English DP - 2012 Sep EZ - 2012/08/30 06:00 DA - 2012/12/21 06:00 DT - 2012/08/30 06:00 YR - 2012 ED - 20121220 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22929292 <341. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23018740 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Abood A AU - Rhodes N FA - Abood, Ahid FA - Rhodes, Nicholas IN - Abood, Ahid. Royal Adelaide Hospital, Adelaide, South Australia, Australia. ahidabood@hotmail.com TI - A simple technique to enhance breast aesthetics using porcine acellular dermal matrix (Strattice) in breast reconstruction. SO - Plastic & Reconstructive Surgery. 130(4):633e-634e, 2012 Oct AS - Plast Reconstr Surg. 130(4):633e-634e, 2012 Oct NJ - Plastic and reconstructive surgery VO - 130 IP - 4 PG - 633e-634e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - *Collagen MH - Esthetics MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Skin Transplantation/mt [Methods] MH - Wound Healing/ph [Physiology] RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Journal Article ID - 10.1097/PRS.0b013e318262f698 [doi] ID - 00006534-201210000-00064 [pii] PP - ppublish LG - English DP - 2012 Oct EZ - 2012/09/29 06:00 DA - 2012/12/15 06:00 DT - 2012/09/29 06:00 YR - 2012 ED - 20121214 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23018740 <342. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23018687 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Seth AK AU - Hirsch EM AU - Fine NA AU - Kim JY FA - Seth, Akhil K FA - Hirsch, Elliot M FA - Fine, Neil A FA - Kim, John Y S IN - Seth, Akhil K. Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Ill. 60611, USA. TI - Utility of acellular dermis-assisted breast reconstruction in the setting of radiation: a comparative analysis. CM - Comment in: Plast Reconstr Surg. 2012 Oct;130(4):759-60; PMID: 23018688 SO - Plastic & Reconstructive Surgery. 130(4):750-8, 2012 Oct AS - Plast Reconstr Surg. 130(4):750-8, 2012 Oct NJ - Plastic and reconstructive surgery VO - 130 IP - 4 PG - 750-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ut [Utilization] MH - Adult MH - *Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Multivariate Analysis MH - Odds Ratio MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/su [Surgery] MH - Postoperative Period MH - Radiotherapy, Adjuvant MH - Regression Analysis MH - Retrospective Studies MH - Risk Assessment MH - Skin Transplantation/ae [Adverse Effects] MH - *Skin Transplantation/mt [Methods] MH - Time Factors MH - *Tissue Expansion MH - Tissue Expansion Devices MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - BACKGROUND: The role of acellular dermis in immediate prosthetic breast reconstruction remains unclear, particularly within a radiated field. The authors evaluated and compare outcomes following reconstruction with and without acellular dermis, and analyzed patients exposed to radiation therapy. AB - METHODS: Retrospective review of 417 consecutive patients (592 breasts) treated from January of 2006 to October of 2008 at one institution was performed. Relevant patient characteristics and follow-up were recorded. Complications were categorized by type and end outcome, including nonoperative, operative, or explantation. Both groups had comparable follow-up (acellular dermis, 23.2 +/- 8.9 months; no acellular dermis, 24.4 +/- 12.7 months; p = 0.23). Appropriate statistical analyses, including multiple regression, were performed. AB - RESULTS: Acellular dermis patients (n = 199 breasts) had larger body mass indexes (p = 0.0001) and more nipple-sparing mastectomies (p = 0.04) than non-acellular dermis patients (n = 393 breasts). Breasts with acellular dermis had larger intraoperative fill volumes (p < 0.0001) and decreased postoperative expansions (p = 0.02), but no decrease in time to implant exchange. There were no significant differences in complication profiles between acellular dermis and non-acellular dermis breasts, after adjusting for other relevant patient variables on regression analysis. After stratifying patients by exposure to radiation, acellular dermis breasts had a decreased risk of all complications related to radiation as compared with non-acellular dermis breasts. AB - CONCLUSIONS: This study suggests that acellular dermis does not adversely affect complication rates following prosthetic breast reconstruction. It may be advantageous, however, in select patients, particularly those undergoing postoperative radiation therapy. Therefore, the choice to use acellular dermis does not compromise outcomes but should be individualized to each patient. ES - 1529-4242 IL - 0032-1052 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e318262f009 [doi] ID - 00006534-201210000-00004 [pii] PP - ppublish LG - English DP - 2012 Oct EZ - 2012/09/29 06:00 DA - 2012/12/15 06:00 DT - 2012/09/29 06:00 YR - 2012 ED - 20121214 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23018687 <343. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23018688 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - McCarthy CM AU - Cordeiro PG FA - McCarthy, Colleen M FA - Cordeiro, Peter G IN - McCarthy, Colleen M. Memorial Sloan-Kettering Cancer Center, New York, NY 10021-6007, USA. TI - Discussion: Utility of acellular dermis-assisted breast reconstruction in the setting of radiation: a comparative analysis. CM - Comment on: Plast Reconstr Surg. 2012 Oct;130(4):750-8; PMID: 23018687 SO - Plastic & Reconstructive Surgery. 130(4):759-60, 2012 Oct AS - Plast Reconstr Surg. 130(4):759-60, 2012 Oct NJ - Plastic and reconstructive surgery VO - 130 IP - 4 PG - 759-60 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis/ut [Utilization] MH - *Breast Neoplasms/rt [Radiotherapy] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Skin Transplantation/mt [Methods] MH - *Tissue Expansion ES - 1529-4242 IL - 0032-1052 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e3182639ace [doi] ID - 00006534-201210000-00005 [pii] PP - ppublish LG - English DP - 2012 Oct EZ - 2012/09/29 06:00 DA - 2012/12/15 06:00 DT - 2012/09/29 06:00 YR - 2012 ED - 20121214 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23018688 <344. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23018685 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Parks JW AU - Hammond SE AU - Walsh WA AU - Adams RL AU - Chandler RG AU - Luce EA FA - Parks, Joseph W FA - Hammond, Sarah E FA - Walsh, William A FA - Adams, Robert L FA - Chandler, Robert G FA - Luce, Edward A IN - Parks, Joseph W. Plastic Surgery Group of Memphis, Tenn., USA. TI - Human acellular dermis versus no acellular dermis in tissue expansion breast reconstruction. CM - Comment in: Plast Reconstr Surg. 2012 Oct;130(4):747-8; PMID: 23018686 SO - Plastic & Reconstructive Surgery. 130(4):739-46, 2012 Oct AS - Plast Reconstr Surg. 130(4):739-46, 2012 Oct NJ - Plastic and reconstructive surgery VO - 130 IP - 4 PG - 739-46 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Adult MH - Age Factors MH - Aged MH - Body Mass Index MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Collagen MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Humans MH - Logistic Models MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Complications/pp [Physiopathology] MH - Postoperative Complications/su [Surgery] MH - Postoperative Period MH - Retrospective Studies MH - Risk Assessment MH - Seroma/et [Etiology] MH - Seroma/pp [Physiopathology] MH - *Skin Transplantation/mt [Methods] MH - Time Factors MH - *Tissue Expansion/mt [Methods] MH - *Tissue Expansion Devices MH - Transplantation, Autologous MH - Wound Healing/ph [Physiology] AB - BACKGROUND: Human acellular dermis has been adopted for routine use in tissue expander reconstruction. The purported benefits include higher intraoperative fill volume, facilitation of lower pole expansion, and enhanced definition of the lower pole of the breast. Recently, concerns have arisen about an increase in postoperative complications with its use. AB - METHODS: A retrospective review was conducted of patients who had immediate postmastectomy breast reconstruction with a tissue expander from July of 2001 to July of 2011. All tissue expander reconstructions before 2005 were performed submuscularly only and all subsequent to 2005 with the use of AlloDerm (LifeCell, Branchburg, N.J.) acellular dermis. Patient demographics were collected, and complications were recorded. AB - RESULTS: The study cohort included 346 patients and 511 immediate breast reconstructions; 232 patients and 346 breasts were reconstructed with and 114 patients and 165 breasts without acellular dermis. Age, body mass index, diabetes, and tobacco use were equivalent in the two groups. Seroma occurrence in the acellular dermis group was nearly twice (30.0 versus 15.1 percent) that of the no acellular dermis breasts, but the tissue expander loss was only slightly higher (11.6 versus 8.5 percent) and not statistically significant. Body mass index in patients who lost their tissue expander was 31 kg/m, statistically significantly higher than in those who did not. AB - CONCLUSIONS: The presence of acellular dermis did not increase the incidence of tissue expander loss, despite a doubling of frequency of seroma. Prior radiation and use of acellular dermis did culminate in a prohibitively high loss rate of the tissue expander. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e318262f06e [doi] ID - 00006534-201210000-00001 [pii] PP - ppublish LG - English DP - 2012 Oct EZ - 2012/09/29 06:00 DA - 2012/12/15 06:00 DT - 2012/09/29 06:00 YR - 2012 ED - 20121214 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23018685 <345. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23018686 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Slavin SA FA - Slavin, Sumner A IN - Slavin, Sumner A. Harvard Medical School, Brookline, Mass. 02446, USA. ssbsj@aol.com TI - Discussion: Human acellular dermis versus no acellular dermis in tissue expansion breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2012 Oct;130(4):739-46; PMID: 23018685 SO - Plastic & Reconstructive Surgery. 130(4):747-8, 2012 Oct AS - Plast Reconstr Surg. 130(4):747-8, 2012 Oct NJ - Plastic and reconstructive surgery VO - 130 IP - 4 PG - 747-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Acellular Dermis MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Skin Transplantation/mt [Methods] MH - *Tissue Expansion/mt [Methods] MH - *Tissue Expansion Devices ES - 1529-4242 IL - 0032-1052 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318265ac8f [doi] ID - 00006534-201210000-00002 [pii] PP - ppublish LG - English DP - 2012 Oct EZ - 2012/09/29 06:00 DA - 2012/12/15 06:00 DT - 2012/09/29 06:00 YR - 2012 ED - 20121214 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23018686 <346. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22382372 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Himsl I AU - Drinovac V AU - Lenhard M AU - Stockl D AU - Weissenbacher T AU - Dian D FA - Himsl, I FA - Drinovac, V FA - Lenhard, M FA - Stockl, D FA - Weissenbacher, T FA - Dian, D IN - Himsl, I. Department of Obstetrics and Gynaecology, Ludwig-Maximillians-University Hospital, Munich, Germany. Isabelle.himsl@med.uni-muenchen.de TI - The use of porcine acellular dermal matrix in silicone implant-based breast reconstruction. SO - Archives of Gynecology & Obstetrics. 286(1):187-92, 2012 Jul AS - Arch Gynecol Obstet. 286(1):187-92, 2012 Jul NJ - Archives of gynecology and obstetrics VO - 286 IP - 1 PG - 187-92 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 6ys, 8710213 IO - Arch. Gynecol. Obstet. SB - Index Medicus CP - Germany MH - Adult MH - Aged MH - Animals MH - Biocompatible Materials MH - Breast Implants/ae [Adverse Effects] MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Esthetics MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Patient Satisfaction MH - Silicones MH - *Skin, Artificial MH - Swine MH - Tissue Scaffolds MH - Touch AB - INTRODUCTION: The most frequently occurring long-term complication in implant-based breast reconstruction is fibrotic capsule formation at the recipient site, with concurrent dysesthesia and poor aesthetic results. Using porcine acellular dermal matrix (PADM) as a connective tissue graft material is supposed to improve the quality and quantity of soft tissue in implant-based breast reconstruction. This study investigates the indications for and the results and the costs of using PADM for the correction or prevention of implant-associated breast deformities. AB - MATERIALS AND METHODS: This study reviewed a single surgeon's experience in the correction or prevention of implant-associated breast deformities with PADM in breast cancer-related breast reconstruction from 2009 to 2011. A total of 23 patients (27 breasts) were included in the study. The aesthetic outcome, the incidence and the type of complication were analysed. Twenty-three women underwent breast cancer-related breast reconstruction: 19 women underwent single-breast reconstruction and four women underwent bilateral reconstruction. AB - RESULTS: Of the 23 patients who underwent breast reconstruction, 18 (78%) were "satisfied" with the aesthetic and haptic outcome after implant-based reconstruction with PADM. One patient (one breast) required another breast operation because of ipsilateral breast cancer recurrence during the follow-up period. PADM-assisted implant-based breast reconstruction has a satisfactory safety profile. AB - CONCLUSION: The use of PADM as an interface matrix for implant-based breast reconstruction yielded predictable and acceptable aesthetic and haptic results by preventing capsular contracture, rippling, implant malposition, soft-tissue thinning and failure of the silicone implant-based breast augmentation. RN - 0 (Biocompatible Materials) RN - 0 (Silicones) ES - 1432-0711 IL - 0932-0067 DO - https://dx.doi.org/10.1007/s00404-012-2266-x PT - Journal Article ID - 10.1007/s00404-012-2266-x [doi] PP - ppublish PH - 2011/11/25 [received] PH - 2012/02/16 [accepted] LG - English EP - 20120302 DP - 2012 Jul EZ - 2012/03/03 06:00 DA - 2012/12/12 06:00 DT - 2012/03/03 06:00 YR - 2012 ED - 20121207 RD - 20120613 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22382372 <347. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23006719 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rocco G AU - Mori S AU - Fazioli F AU - La Rocca A AU - Martucci N AU - Setola S FA - Rocco, Gaetano FA - Mori, Stefano FA - Fazioli, Flavio FA - La Rocca, Antonello FA - Martucci, Nicola FA - Setola, Sergio IN - Rocco, Gaetano. Division of Thoracic Surgery, Department of Thoracic Surgery and Oncology, National Cancer Institute, Pascale Foundation, Naples, Italy. gaetano.rocco@btopenworld.com TI - The use of biomaterials for chest wall reconstruction 30 years after radical surgery and radiation. SO - Annals of Thoracic Surgery. 94(4):e109-10, 2012 Oct AS - Ann Thorac Surg. 94(4):e109-10, 2012 Oct NJ - The Annals of thoracic surgery VO - 94 IP - 4 PG - e109-10 PI - Journal available in: Print PI - Citation processed from: Internet JC - 15030100R IO - Ann. Thorac. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - Netherlands MH - Acellular Dermis MH - Aged MH - *Biocompatible Materials MH - *Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy, Radical/mt [Methods] MH - Prosthesis Design MH - Skin Transplantation MH - *Surgical Flaps MH - *Thoracoplasty/mt [Methods] MH - Time Factors MH - Titanium AB - The combination of titanium plates and acellular collagen matrix was used to restore anterior chest wall integrity in a 68-year-old woman more than 30 years after a Halsted mastectomy and radiation treatment. A vertical rectus abdominis muscle flap was used for myocutaneous coverage of the reconstructed chest wall. Partial necrosis of the flap caused prolonged exposure of the collagen matrix and the titanium plates, which were then covered with a free skin graft. Long-term results were satisfactory despite continued infection treated with vacuum-assisted closure and surgical debridement. Recently introduced materials for chest wall reconstruction may offer resilience to infection, tolerability, and stability, and their use may be contemplated when the potential for local morbidity is high. Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. RN - 0 (Biocompatible Materials) RN - D1JT611TNE (Titanium) ES - 1552-6259 IL - 0003-4975 DI - S0003-4975(12)01828-0 DO - https://dx.doi.org/10.1016/j.athoracsur.2012.08.029 PT - Case Reports PT - Journal Article ID - S0003-4975(12)01828-0 [pii] ID - 10.1016/j.athoracsur.2012.08.029 [doi] PP - ppublish PH - 2012/03/30 [received] PH - 2012/07/23 [revised] PH - 2012/08/01 [accepted] LG - English DP - 2012 Oct EZ - 2012/09/26 06:00 DA - 2012/12/10 06:00 DT - 2012/09/26 06:00 YR - 2012 ED - 20121204 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=23006719 <348. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22633394 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fox PM AU - Lee GK FA - Fox, Paige M FA - Lee, Gordon K IN - Fox, Paige M. Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford, CA, United States. TI - Tissue expander with acellular dermal matrix for breast reconstruction infected by an unusual pathogen: Candida parapsilosis. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 65(10):e286-9, 2012 Oct AS - J Plast Reconstr Aesthet Surg. 65(10):e286-9, 2012 Oct NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 65 IP - 10 PG - e286-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Acellular Dermis/ae [Adverse Effects] MH - Antifungal Agents/tu [Therapeutic Use] MH - Breast Implants/ae [Adverse Effects] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - *Candida/cl [Classification] MH - *Candidiasis/et [Etiology] MH - Candidiasis/th [Therapy] MH - Combined Modality Therapy MH - Drainage/mt [Methods] MH - Female MH - Follow-Up Studies MH - Graft Survival MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Postoperative Care/mt [Methods] MH - *Prosthesis-Related Infections/mi [Microbiology] MH - Prosthesis-Related Infections/th [Therapy] MH - Reoperation/mt [Methods] MH - Risk Assessment MH - Therapeutic Irrigation/mt [Methods] MH - *Tissue Expansion Devices/ae [Adverse Effects] MH - Wound Healing/ph [Physiology] AB - Infections occur in approximately 2-5% percent of women undergoing breast reconstruction by tissue expansion depending on patient characteristics and timing of reconstruction. Bacteria, specifically Staphylococci, are the most common pathogens. Treatment varies depending on the surgeon and the aggressiveness of the infection. We report a case of unilateral tissue expander infection with Candida parapsilosis in an otherwise healthy female undergoing immediate tissue expander placement after bilateral nipple-sparing mastectomies. The patient was treated with a one-stage irrigation, debridement, and tissue expander exchange as well as a 21-day course of oral antifungal therapy. Her infection resolved and she was able to complete her implant-based reconstruction. C. parapsilosis is usually responsible for infections in critically ill patients found in association with central lines, peritoneal dialysis catheters and prosthetic heart valves. The affinity of C. parapsilosis for foreign material makes it a causative agent worth considering in difficult to treat tissue expander infections. Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (Antifungal Agents) ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(12)00257-4 DO - https://dx.doi.org/10.1016/j.bjps.2012.04.049 PT - Case Reports PT - Journal Article ID - S1748-6815(12)00257-4 [pii] ID - 10.1016/j.bjps.2012.04.049 [doi] PP - ppublish PH - 2011/06/30 [received] PH - 2012/03/11 [revised] PH - 2012/04/30 [accepted] LG - English EP - 20120525 DP - 2012 Oct EZ - 2012/05/29 06:00 DA - 2012/12/10 06:00 DT - 2012/05/29 06:00 YR - 2012 ED - 20121128 RD - 20120917 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22633394 <349. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21734545 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cassileth L AU - Kohanzadeh S AU - Amersi F FA - Cassileth, Lisa FA - Kohanzadeh, Som FA - Amersi, Farin IN - Cassileth, Lisa. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. info@drcassileth.com TI - One-stage immediate breast reconstruction with implants: a new option for immediate reconstruction. SO - Annals of Plastic Surgery. 69(2):134-8, 2012 Aug AS - Ann Plast Surg. 69(2):134-8, 2012 Aug NJ - Annals of plastic surgery VO - 69 IP - 2 PG - 134-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Acellular Dermis MH - Adult MH - Aged MH - Breast Implantation/is [Instrumentation] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Collagen MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy MH - Middle Aged MH - Outcome Assessment (Health Care) MH - Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/et [Etiology] MH - Risk Factors MH - Silicone Gels MH - Time Factors AB - BACKGROUND: The current standard of care for breast implant reconstruction after mastectomy is 2-stage reconstruction with placement of tissue expanders followed by implants. The immediate use of implants at the time of mastectomy, which eliminates the need for a second operative procedure, has been sparsely reported and is not yet accepted as the standard of care. This study describes a 1-stage immediate implant reconstruction technique and evaluates its risks. AB - METHODS: Between 2005 and 2010, immediate implant reconstruction was performed in 43 sequential patients on a total of 78 breasts. Permanent silicone implants were placed at the time of mastectomy with the assistance of acellular dermal matrix (ADM). Follow-up was for an average of 575 days. Implant sizes varied widely from 175 to 800 mL. In order to create the correct breast shape and implant placement, specific techniques of acellular dermal matrix placement in the reconstruction were critically important. Aesthetic evaluation of the patients was performed, evaluating pre- and postoperative photos by 20 evaluators. Pictures were rated according to a 4-point Harris breast scale. A 2-sided paired t test was then used to compare the rating scores. AB - RESULTS: Complication rates were as follows: seroma occurred in 6.4% of breasts; infection resolving with antibiotics occurred in 2.6%; infection requiring implant removal occurred in 3.8%; and hematoma occurred in 1.3%. Neither preoperative breast size nor implant size correlated to an increased risk of complications (P>0.05). Complication rate increased with age (P=0.02). The average score for the preoperative images was 2.1, whereas the postoperative average was 2.4. This represented a statistically significant improvement above the baseline (preoperative) breasts with a P<0.001, according to a 2-sided paired t test. AB - CONCLUSIONS: With complication rates similar to previously reported tissue expander reconstructions, immediate implant reconstruction is a viable alternative to 2-stage expander reconstruction, presenting many advantages over expander reconstruction while offering the same risk profile and eliminating the additional risks, costs, and discomfort of a second procedure. Additionally, aesthetic results were highly satisfactory according to patients themselves and based on evaluation by independent observers. RN - 0 (Alloderm) RN - 0 (Silicone Gels) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3182250c60 PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e3182250c60 [doi] PP - ppublish LG - English DP - 2012 Aug EZ - 2011/07/08 06:00 DA - 2012/12/10 06:00 DT - 2011/07/08 06:00 YR - 2012 ED - 20121127 RD - 20120718 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21734545 <350. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22406261 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chepla KJ AU - Dagget JR AU - Soltanian HT FA - Chepla, Kyle J FA - Dagget, Justin R FA - Soltanian, Hooman T IN - Chepla, Kyle J. University Hospitals-Case Medical Center, Department of Plastic Surgery, 11100 Euclid Ave., Mailstop LKS 5044, Cleveland, OH 44106, USA. TI - The partial AlloDerm sling: reducing allograft costs associated with breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 65(7):924-30, 2012 Jul AS - J Plast Reconstr Aesthet Surg. 65(7):924-30, 2012 Jul NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 65 IP - 7 PG - 924-30 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Adult MH - Aged MH - *Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Chi-Square Distribution MH - Collagen/ec [Economics] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - Middle Aged MH - Postoperative Complications MH - Retrospective Studies MH - *Skin, Artificial MH - *Tissue Expansion Devices MH - Treatment Outcome AB - BACKGROUND: Many surgeons now incorporate Acellular Dermal Matrix (ADM) into expander-based breast reconstruction. ADM is safe, provides full expander coverage, eliminates the need for additional muscular dissection and has improved aesthetic outcomes. However, its use increases surgical costs. Whether this cost is offset by decreased operative times or a reduced number of revision procedures is unknown. AB - METHODS: We have developed a new technique that minimises the amount of ADM required in many patients. The 'partial sling' approach has been used for 145 consecutive patients (197 breasts) by a single surgeon from 2007 to 2010. After mastectomy, any portion of the pectoralis major insertion at, or <1 cm from, the planned inframmary fold is left intact and becomes the inferior margin of the expander pocket. The minimal size of ADM required is then determined by measuring from the pectoralis to the lateral breast margin. In this study, we exclusively used AlloDerm. Preoperative breast measurements, intra-operative fill volume, time to exchange procedure, number of expansion procedures and complications were recorded for all patients. AB - RESULTS: Patients were grouped according to the surface area (cm(2)) of ADM required. Good aesthetic outcomes were obtained in all groups. Two groups had a significant difference in intra-operative fill volumes but this did not correlate to an increase in the number of expansion procedures required. Of 197 reconstructed breasts less than 64 cm(2) of ADM was used for 40 breasts (20%). AB - CONCLUSIONS: The partial AlloDerm sling can minimise the costs associated with ADM use in breast reconstruction for many patients without increasing complications or altering aesthetic outcomes. Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DO - https://dx.doi.org/10.1016/j.bjps.2012.02.016 PT - Journal Article ID - S1748-6815(12)00097-6 [pii] ID - 10.1016/j.bjps.2012.02.016 [doi] PP - ppublish PH - 2011/05/03 [received] PH - 2011/11/21 [revised] PH - 2012/02/04 [accepted] LG - English EP - 20120309 DP - 2012 Jul EZ - 2012/03/13 06:00 DA - 2012/09/21 06:00 DT - 2012/03/13 06:00 YR - 2012 ED - 20120920 RD - 20120618 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22406261 <351. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22743916 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bonomi S AU - Settembrini F AU - Salval A AU - Gilardi R AU - Musumarra G FA - Bonomi, Stefano FA - Settembrini, Fernanda FA - Salval, Andre FA - Gilardi, Roberta FA - Musumarra, Gaetano TI - Implant-based breast reconstruction with acellular dermal matrix. CM - Comment on: Plast Reconstr Surg. 2011 Dec;128(6):1162-9; PMID: 22094735 SO - Plastic & Reconstructive Surgery. 130(1):190e-191e; author reply 191e-192e, 2012 Jul AS - Plast Reconstr Surg. 130(1):190e-191e; author reply 191e-192e, 2012 Jul NJ - Plastic and reconstructive surgery VO - 130 IP - 1 PG - 190e-191e; author reply 191e-192e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Biocompatible Materials MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Postoperative Complications/et [Etiology] RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318254fc89 PT - Comment PT - Letter ID - 10.1097/PRS.0b013e318254fc89 [doi] ID - 00006534-201207000-00069 [pii] PP - ppublish LG - English DP - 2012 Jul EZ - 2012/06/30 06:00 DA - 2012/09/05 06:00 DT - 2012/06/30 06:00 YR - 2012 ED - 20120904 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22743916 <352. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22743866 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL AU - Seruya M AU - Rao SS AU - Rottman S AU - Stolle E AU - Cohen M AU - Rose KM AU - Parikh PM AU - Nahabedian MY FA - Spear, Scott L FA - Seruya, Mitchel FA - Rao, Samir S FA - Rottman, Steven FA - Stolle, Ellen FA - Cohen, Michael FA - Rose, Kirsten M FA - Parikh, Pranay M FA - Nahabedian, Maurice Y IN - Spear, Scott L. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. spears@gunet.georgetown.edu TI - Two-stage prosthetic breast reconstruction using AlloDerm including outcomes of different timings of radiotherapy. SO - Plastic & Reconstructive Surgery. 130(1):1-9, 2012 Jul AS - Plast Reconstr Surg. 130(1):1-9, 2012 Jul NJ - Plastic and reconstructive surgery VO - 130 IP - 1 PG - 1-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implants MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/re [Radiation Effects] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Prosthesis Design MH - Prosthesis Failure MH - Radiation Dosage MH - Retrospective Studies MH - Skin, Artificial MH - Time Factors MH - Tissue Expansion/mt [Methods] MH - Young Adult AB - BACKGROUND: The authors compared the outcomes of two-stage, acellular dermal matrix (AlloDerm)-assisted prosthetic breast reconstruction including different timings of radiotherapy. AB - METHODS: A review of two-stage, AlloDerm-assisted, prosthetic breast reconstructions from 2004 to 2010 was performed. All data were recorded prospectively and the study population was stratified by the timing of radiotherapy. Complications were analyzed following first- and second-stage reconstruction. The Spear-Baker classification of capsular contracture was modified for irradiated devices. Reconstructive failure was defined as nonelective removal of a breast prosthesis. AB - RESULTS: : AlloDerm-assisted prosthetic reconstruction was performed in 289 women (428 breasts). After first-stage reconstruction, clinically significant capsular contracture rates (grade III/IV) were higher in the radiation therapy during expansion group and in the radiation therapy before mastectomy group compared with the no-radiation therapy group. Three hundred fifty-three breasts (85.9 percent) successfully underwent second-stage reconstruction, with a median follow-up of 15.2 months. Of those 353 breasts, clinically significant capsular contracture (grade III/IV) was highest in the radiation therapy during expansion group. More often than in the other groups, the radiation therapy during expansion group failed two-stage reconstruction and required flaps in addition or as replacement. AB - CONCLUSIONS: In AlloDerm-assisted prosthetic breast reconstruction, irradiated devices demonstrated higher rates of clinically significant capsular contracture following the first stage. These rates declined considerably on completion of reconstruction, with prostheses irradiated during expansion still having the highest frequency of clinically significant capsular contracture. With the follow-up reported, irradiated devices failed breast reconstruction less frequently and required autologous tissue less often than has been historically reported without acellular dermal matrix. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182547a45 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e3182547a45 [doi] ID - 00006534-201207000-00001 [pii] PP - ppublish LG - English DP - 2012 Jul EZ - 2012/06/30 06:00 DA - 2012/09/05 06:00 DT - 2012/06/30 06:00 YR - 2012 ED - 20120904 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22743866 <353. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22654532 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Craft RO AU - Rebecca AM AU - Flahive C AU - Casey WJ 3rd AU - Dueck A AU - Harold KL FA - Craft, Randall O FA - Rebecca, Alanna M FA - Flahive, Colleen FA - Casey, William J 3rd FA - Dueck, Amylou FA - Harold, Kristi L IN - Craft, Randall O. Harvard Plastic Surgery, Harvard College, Boston, Massachusetts; TI - Does size matter? Technical considerations of a regenerative tissue matrix for use in reconstructive surgery. SO - Canadian Journal of Plastic Surgery. 19(2):51-2, 2011 AS - Can. j. plast. surg.. 19(2):51-2, 2011 NJ - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique VO - 19 IP - 2 PG - 51-2 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9434932 IO - Can J Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328118 CP - Canada KW - Acellular dermis; AlloDerm; Biological; Reconstructive AB - INTRODUCTION: Acellular dermal matrices have been used with increasing frequency in both reconstructive and cosmetic surgery. While many studies have described the safety and morbidity profiles of these materials, little is known about the relative mechanical properties of individual sheets of allograft harvested from distinct donors. AB - METHODS: Sixty-two individual sheets of an acellular dermal matrix from distinct lot numbers (signifying different donors of the dermis) were prospectively analyzed before use. Distribution of thickness according to manufacturer specifications in the dry state were as follows: 0.009 inches to 0.013 inches (1 [1.6%]); 0.79 mm to 1.78 mm (3 [4.8%]); 0.79 mm to 2.03 mm (5 [8%]); 0.8 mm to 3.3 mm (1 [1.6%]); 1.8 mm to 3.3 mm (10 [16.1%]) and 28 mm (6 [9.7%]). The size of the matrix was recorded while dry, after hydration and following stretch. The percentage change in surface area was recorded for each lot. AB - RESULTS: The 62 reconstructive cases included breast implant reconstruction (2 [3.2%]); ventral hernia repair (11 [17.7%]); abdominal closure following autologous tissue harvest (6 [9.6%]); autologous breast reconstruction (37 [59.6%]); extremity wound closures (3 [4.8%]) and reinforcement of vertical rectus abdominis muscle closure (3 [4.8%]). The mean percentage change in the size of the acellular dermal matrix to the hydrated state was 58% (36 of 62; thickness 0.06 mm to 3.30 mm); the mean percentage change in size from dry state was 7.14% (range 0% to 18.7%). The mean percentage change in the size of the hydrated matrix to the stretched state was 25.7% (range 0.25% to 70.6%). The variability in elasticity among the individual sheets was significant (P<0.0005). AB - CONCLUSION: The acellular dermal matrix displayed highly variable elastic properties among distinct donors. This may be significant in procedures in which symmetry is critical. ES - 1918-1507 IL - 1195-2199 PT - Journal Article ID - PMC3328118 [pmc] PP - ppublish LG - English DP - 2011 EZ - 2012/06/02 06:00 DA - 2012/06/02 06:01 DT - 2012/06/02 06:00 YR - 2011 ED - 20120823 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=22654532 <354. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22654531 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Chopp D AU - Rawlani V AU - Ellis M AU - Johnson SA AU - Buck DW 2nd AU - Khan S AU - Bethke K AU - Hansen N AU - Kim JY FA - Chopp, David FA - Rawlani, Vinay FA - Ellis, Marco FA - Johnson, Sarah A FA - Buck, Donald W 2nd FA - Khan, Seema FA - Bethke, Kevin FA - Hansen, Nora FA - Kim, John Ys IN - Chopp, David. Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago; TI - A geometric analysis of mastectomy incisions: Optimizing intraoperative breast volume. SO - Canadian Journal of Plastic Surgery. 19(2):45-50, 2011 AS - Can. j. plast. surg.. 19(2):45-50, 2011 NJ - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique VO - 19 IP - 2 PG - 45-50 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9434932 IO - Can J Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328110 CP - Canada KW - Mastectomy incision; Mathematical model; Tissue expander; Volume AB - INTRODUCTION: The advent of acellular dermis-based tissue expander breast reconstruction has placed an increased emphasis on optimizing intraoperative volume. Because skin preservation is a critical determinant of intraoperative volume expansion, a mathematical model was developed to capture the influence of incision dimension on subsequent tissue expander volumes. AB - METHODS: A mathematical equation was developed to calculate breast volume via integration of a geometrically modelled breast cross-section. The equation calculates volume changes associated with excised skin during the mastectomy incision by reducing the arc length of the cross-section. The degree of volume loss is subsequently calculated based on excision dimensions ranging from 35 mm to 60 mm. AB - RESULTS: A quadratic relationship between breast volume and the vertical dimension of the mastectomy incision exists, such that incrementally larger incisions lead to a disproportionally greater amount of volume loss. The vertical dimension of the mastectomy incision - more so than the horizontal dimension - is of critical importance to maintain breast volume. Moreover, the predicted volume loss is more profound in smaller breasts and primarily occurs in areas that affect breast projection on ptosis. AB - CONCLUSIONS: The present study is the first to model the relationship between the vertical dimensions of the mastectomy incision and subsequent volume loss. These geometric principles will aid in optimizing intra-operative volume expansion during expander-based breast reconstruction. ES - 1918-1507 IL - 1195-2199 PT - Journal Article ID - PMC3328110 [pmc] PP - ppublish LG - English DP - 2011 EZ - 2012/06/02 06:00 DA - 2012/06/02 06:01 DT - 2012/06/02 06:00 YR - 2011 ED - 20120823 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=22654531 <355. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22531395 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hill JL AU - Wong L AU - Kemper P AU - Buseman J AU - Davenport DL AU - Vasconez HC FA - Hill, Joseph L FA - Wong, Lesley FA - Kemper, Pamela FA - Buseman, Jason FA - Davenport, Daniel L FA - Vasconez, Henry C IN - Hill, Joseph L. Division of Plastic Surgery, University of Kentucky College of Medicine, Lexington, KY, USA. TI - Infectious complications associated with the use of acellular dermal matrix in implant-based bilateral breast reconstruction. SO - Annals of Plastic Surgery. 68(5):432-4, 2012 May AS - Ann Plast Surg. 68(5):432-4, 2012 May NJ - Annals of plastic surgery VO - 68 IP - 5 PG - 432-4 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Biocompatible Materials/ad [Administration & Dosage] MH - *Biocompatible Materials/ae [Adverse Effects] MH - *Breast Implantation/is [Instrumentation] MH - Dermis MH - Female MH - Humans MH - Logistic Models MH - Middle Aged MH - Multivariate Analysis MH - Retrospective Studies MH - Risk Factors MH - Surgical Wound Infection/ep [Epidemiology] MH - *Surgical Wound Infection/et [Etiology] AB - BACKGROUND: The use of acellular dermal matrix (ADM) has become a routine practice in implant-based breast reconstruction. Bilateral mastectomy is becoming more popular in cases of unilateral breast cancer. ADM has been associated with an increased incidence of complications. AB - METHODS: We identified cases of bilateral implant-based breast reconstruction over a 5-year period. Data collection included medical comorbities, details of operative management, and details of postoperative cancer treatment. AB - RESULTS: On univariate analysis, the use of ADM (31% vs. 7%, P = 0.018), smoking (37% vs. 13%, P = 0.045), and open wound (55% vs. 13%, P = 0.006) were significantly associated with increased risk of infection. Multivariate analysis revealed open wound as the strongest predictor of infection. AB - CONCLUSIONS: The use of ADM is associated with an increased risk of infection in bilateral implant-based breast reconstruction. However, it does not appear to be an independent risk factor by itself. RN - 0 (Biocompatible Materials) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31823b6ac6 PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e31823b6ac6 [doi] ID - 00000637-201205000-00005 [pii] PP - ppublish LG - English DP - 2012 May EZ - 2012/04/26 06:00 DA - 2012/08/21 06:00 DT - 2012/04/26 06:00 YR - 2012 ED - 20120820 RD - 20120425 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22531395 <356. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21825969 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Collis GN AU - TerKonda SP AU - Waldorf JC AU - Perdikis G FA - Collis, George N FA - TerKonda, Sarvam P FA - Waldorf, James C FA - Perdikis, Galen IN - Collis, George N. Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA. TI - Acellular dermal matrix slings in tissue expander breast reconstruction: are there substantial benefits?. SO - Annals of Plastic Surgery. 68(5):425-8, 2012 May AS - Ann Plast Surg. 68(5):425-8, 2012 May NJ - Annals of plastic surgery VO - 68 IP - 5 PG - 425-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Biocompatible Materials/ad [Administration & Dosage] MH - Breast Implantation MH - Breast Neoplasms/su [Surgery] MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty/is [Instrumentation] MH - Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - Retrospective Studies MH - *Tissue Expansion Devices MH - Treatment Outcome AB - Acellular dermal matrix (ADM) slings in breast reconstruction are increasingly used but are not yet validated. This study compares immediate, expander-based breast reconstruction with and without the use of inferolateral ADM slings. There were 63 patients (106 breasts) in the ADM group and 42 patients (68 breasts) in the control group. Initial intraoperative fill volumes were significantly greater in the ADM group, median 69% full (250 mL) versus 50% full (180 mL; P < 0.001). However, the number of days to complete expansion between the 2 groups was similar. One less office visit was required to complete the fills in the ADM group (P < 0.01). Drains were removed 3 days later in the ADM group (P < 0.01). Overall complication rate was greater in the ADM group (18.9% vs. 7.4%, P < 0.05), with a slightly higher percentage of expanders requiring removal due to infection in the ADM group (5.7% vs. 4.4%, P = NS). This study suggests inferolateral ADM slings in expander-based breast reconstruction allow for significantly increased initial fill volumes and may offer an aesthetic advantage; however, its use is costly and increases complications. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e318225833f PT - Comparative Study PT - Evaluation Studies PT - Journal Article ID - 10.1097/SAP.0b013e318225833f [doi] PP - ppublish LG - English DP - 2012 May EZ - 2011/08/10 06:00 DA - 2012/08/21 06:00 DT - 2011/08/10 06:00 YR - 2012 ED - 20120820 RD - 20120426 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21825969 <357. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22634688 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Peled AW AU - Foster RD AU - Garwood ER AU - Moore DH AU - Ewing CA AU - Alvarado M AU - Hwang ES AU - Esserman LJ FA - Peled, Anne Warren FA - Foster, Robert D FA - Garwood, Elisabeth R FA - Moore, Dan H FA - Ewing, Cheryl A FA - Alvarado, Michael FA - Hwang, E Shelley FA - Esserman, Laura J IN - Peled, Anne Warren. Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco, USA. TI - The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement study. CM - Comment in: Plast Reconstr Surg. 2013 Feb;131(2):279e; PMID: 23358028 CM - Comment in: Plast Reconstr Surg. 2013 Feb;131(2):278e-279e; PMID: 23358027 SO - Plastic & Reconstructive Surgery. 129(6):901e-908e, 2012 Jun AS - Plast Reconstr Surg. 129(6):901e-908e, 2012 Jun NJ - Plastic and reconstructive surgery VO - 129 IP - 6 PG - 901e-908e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Breast Neoplasms/su [Surgery] MH - *Dermis/tr [Transplantation] MH - *Extracellular Matrix/tr [Transplantation] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - Middle Aged MH - Nipples/su [Surgery] MH - *Postoperative Care/mt [Methods] MH - Prospective Studies MH - Quality Improvement MH - *Skin Transplantation/mt [Methods] MH - Surgical Flaps MH - *Tissue Expansion/mt [Methods] AB - BACKGROUND: Neither outcome after total skin-sparing mastectomy and expander-implant reconstruction using acellular dermal matrix nor a strategy for optimal acellular dermal matrix selection criteria has been well described. AB - METHODS: Prospective review of three patient cohorts undergoing total skin-sparing mastectomy with preservation of the nipple-areola complex and immediate expander-implant reconstruction from 2006 to 2010 was performed. Cohort 1 (no acellular dermal matrix) comprised 90 cases in which acellular dermal matrix was not used. Cohort 2 (consecutive acellular dermal matrix) included the next 100 consecutive cases, which all received acellular dermal matrix. Cohort 3 (selective acellular dermal matrix) consisted of the next 260 cases, in which acellular dermal matrix was selectively used based on mastectomy skin flap thickness. Complication rates were compared using chi-square analysis. AB - RESULTS: The study included 450 cases in 288 patients. Mean follow-up was 25.5 months. Infection occurred in 27.8 percent of the no-acellular dermal matrix cases, 20 percent of the consecutive cases, and 15.8 percent of the selective cases (p = 0.04). Unplanned return to the operating room was required in 23.3, 11, and 10 percent of cases, respectively (p = 0.004). Expander-implant loss occurred in 17.8, 7, and 5 percent of cases, respectively (p = 0.001). Additional analysis of the odds ratios of developing complications after postmastectomy radiation therapy demonstrated a specific protective benefit of acellular dermal matrix in irradiated patients. AB - CONCLUSIONS: Acellular dermal matrix use in expander-implant reconstruction after total skin-sparing mastectomy reduced major postoperative complications in this study. Maximal benefit is achieved with selected use in patients with thin mastectomy skin flaps and those receiving radiation therapy. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31824ec447 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e31824ec447 [doi] ID - 00006534-201206000-00003 [pii] PP - ppublish LG - English DP - 2012 Jun EZ - 2012/05/29 06:00 DA - 2012/08/08 06:00 DT - 2012/05/29 06:00 YR - 2012 ED - 20120807 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22634688 <358. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22634641 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hirsch EM AU - Dumanian GA FA - Hirsch, Elliot M FA - Dumanian, Gregory A IN - Hirsch, Elliot M. Division of Plastic Surgery, Department of Surgery, Northwestern Feinberg School of Medicine, Chicago, IL, USA. TI - Discussion: AlloDerm and Strattice in breast reconstruction: a comparison and techniques for optimizing outcomes. CM - Comment on: Plast Reconstr Surg. 2012 Jun;129(6):1223-33; PMID: 22327891 SO - Plastic & Reconstructive Surgery. 129(6):1234-5, 2012 Jun AS - Plast Reconstr Surg. 129(6):1234-5, 2012 Jun NJ - Plastic and reconstructive surgery VO - 129 IP - 6 PG - 1234-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Bandages MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] RN - 0 (Alloderm) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182546517 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e3182546517 [doi] ID - 00006534-201206000-00002 [pii] PP - ppublish LG - English DP - 2012 Jun EZ - 2012/05/29 06:00 DA - 2012/08/08 06:00 DT - 2012/05/29 06:00 YR - 2012 ED - 20120807 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22634641 <359. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22327891 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Glasberg SB AU - Light D FA - Glasberg, Scot B FA - Light, David IN - Glasberg, Scot B. Lenox Hill Hospital, New York, NY, USA. scotbg@juno.com TI - AlloDerm and Strattice in breast reconstruction: a comparison and techniques for optimizing outcomes. CM - Comment in: Plast Reconstr Surg. 2012 Jun;129(6):1234-5; PMID: 22634641 SO - Plastic & Reconstructive Surgery. 129(6):1223-33, 2012 Jun AS - Plast Reconstr Surg. 129(6):1223-33, 2012 Jun NJ - Plastic and reconstructive surgery VO - 129 IP - 6 PG - 1223-33 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Bandages MH - Breast Neoplasms/su [Surgery] MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Period MH - Retrospective Studies MH - Skin, Artificial MH - Tissue Expansion/mt [Methods] MH - Treatment Outcome MH - Wound Healing MH - Young Adult AB - BACKGROUND: Acellular dermal matrices are increasingly used to reinforce the lower pole of the breast during tissue expander/implant breast reconstruction. Although a low complication rate and good aesthetic outcome have been reported, meticulous technique is important for success. This retrospective study compared the clinical course and postoperative outcome of women who underwent breast reconstruction using AlloDerm or Strattice in the authors' practice and highlights key technical considerations that are important for optimizing outcomes. AB - METHODS: Patient records were reviewed for demographic data, operative parameters (length and volume of drainage), and type and frequency of postoperative complications, which were compared between the AlloDerm and Strattice groups. Biopsy specimens of acellular dermal matrices were taken for histologic analyses. AB - RESULTS: Ninety-six patients (126 reconstructions) received AlloDerm, and 90 (144 reconstructions) received Strattice. Total complications were significantly higher with AlloDerm (21.4 percent versus 6.3 percent; p = 0.0003) and were driven by a significantly higher seroma rate (12.7 percent versus 1.4 percent; p = 0.0003). All other complications were similar between the groups. The capsular contracture rate (grade 1 or 2) was 2.4 percent with AlloDerm and 2.8 percent with Strattice, indicating that both may play a role in capsule formation. This was supported by histologic analyses indicating an absence of synovia-like metaplasia at the acellular dermal matrix/tissue expander interface. AB - CONCLUSIONS: : Complications in this series were of low severity, which, together with consistent clinical outcomes seen in the authors' practice, justifies the cost associated with the use of acellular dermal matrices in breast reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic: III. RN - 0 (Alloderm) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31824ec429 PT - Comparative Study PT - Journal Article PT - Multicenter Study ID - 10.1097/PRS.0b013e31824ec429 [doi] PP - ppublish LG - English DP - 2012 Jun EZ - 2012/02/14 06:00 DA - 2012/08/08 06:00 DT - 2012/02/14 06:00 YR - 2012 ED - 20120807 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22327891 <360. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482361 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Baxter RA FA - Baxter, Richard A IN - Baxter, Richard A. Plastic Surgery Clinic, 6100 219th Street SW, Mountlake Terrace, WA 98043, USA. drbaxter@drbaxter.com TI - Current state of the art for acellular dermal matrices in breast surgery. SO - Clinics in Plastic Surgery. 39(2):ix, 2012 Apr AS - Clin Plast Surg. 39(2):ix, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - ix PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Skin, Artificial MH - *Surgical Flaps MH - *Tissue Expansion/mt [Methods] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.008 PT - Editorial ID - S0094-1298(12)00010-7 [pii] ID - 10.1016/j.cps.2012.02.008 [doi] PP - ppublish LG - English EP - 20120229 DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482361 <361. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482360 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Macadam SA AU - Lennox PA FA - Macadam, Sheina A FA - Lennox, Peter A IN - Macadam, Sheina A. Division of Plastic & Reconstructive Surgery, University of British Columbia and Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada. drsamacadam@gmail.com TI - Acellular dermal matrices: economic considerations in reconstructive and aesthetic breast surgery. [Review] SO - Clinics in Plastic Surgery. 39(2):187-216, 2012 Apr AS - Clin Plast Surg. 39(2):187-216, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 187-216 PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Collagen/ec [Economics] MH - Cost-Benefit Analysis MH - Female MH - Humans MH - *Mammaplasty/ec [Economics] MH - Mammaplasty/mt [Methods] MH - Mastectomy MH - Skin, Artificial AB - This article is a review of cost considerations and outcomes pertaining to the use of acellular dermal matrices (ADMs) in reconstructive and aesthetic breast surgery. The history of the use of ADMs in breast surgery and all case series describing outcomes and use of ADM in breast reconstructive and aesthetic surgery are reviewed. Weighted averages for clinically relevant outcomes for reconstructive and aesthetic breast surgery are provided. Cost considerations of ADM use in breast surgery are described and as an example, a single institution's experience with implementation of ADM into a preexisting breast surgery program, is used. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.007 PT - Journal Article PT - Review ID - S0094-1298(12)00009-0 [pii] ID - 10.1016/j.cps.2012.02.007 [doi] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482360 <362. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482359 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ayeni OA AU - Ibrahim AM AU - Lin SJ AU - Slavin SA FA - Ayeni, Olubimpe A FA - Ibrahim, Ahmed M S FA - Lin, Samuel J FA - Slavin, Sumner A IN - Ayeni, Olubimpe A. Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Boston, MA 02215, USA. TI - Acellular dermal matrices in breast surgery: tips and pearls. [Review] SO - Clinics in Plastic Surgery. 39(2):177-86, 2012 Apr AS - Clin Plast Surg. 39(2):177-86, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 177-86 PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Materials Testing MH - Skin, Artificial AB - Acellular dermal matrices (ADMs) have been used for postmastectomy breast reconstruction, primary and secondary breast augmentation, and reduction mammaplasty. In postmastectomy breast reconstruction, ADMs can be used to either create an implant pocket in single-stage reconstruction or to create the inferolateral portion of the tissue expander pocket in two-stage reconstruction. Specific deformities after cosmetic breast augmentation such as contour irregularities and implant malposition can be addressed with ADMs. The use of ADMs is a safe alternative for the correction of breast deformities after reconstructive and aesthetic breast surgery. Copyright © 2012. Published by Elsevier Inc. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.003 PT - Journal Article PT - Review ID - S0094-1298(12)00005-3 [pii] ID - 10.1016/j.cps.2012.02.003 [doi] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482359 <363. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482358 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cheng A AU - Saint-Cyr M FA - Cheng, Angela FA - Saint-Cyr, Michel IN - Cheng, Angela. Department of Plastic Surgery, UT Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390-9132, USA. TI - Comparison of different ADM materials in breast surgery. [Review] SO - Clinics in Plastic Surgery. 39(2):167-75, 2012 Apr AS - Clin Plast Surg. 39(2):167-75, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 167-75 PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Materials Testing MH - Skin, Artificial AB - This is a brief review of the history of the role of acellular dermal matrices in breast reconstruction surgery, with a summary of several currently available products, including a table of comparisons. Key features, including biologic tissue source, surgical preparation, sterility, polarity, contraindications, shelf life, and cost, are examined. A paucity of data exists to directly compare AlloDerm, DermaMatrix, StratticeTM, PermacolTM, DermACELL, FlexHD, SurgiMend, and ALLOMAXTM for breast reconstruction; most studies relate to hernia repair. An ideal acellular dermal matrix product is still unavailable but the information provided in this review should facilitate a breast surgeons decision-making process. Copyright Published by Elsevier Inc. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.004 PT - Journal Article PT - Review ID - S0094-1298(12)00006-5 [pii] ID - 10.1016/j.cps.2012.02.004 [doi] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482358 <364. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482357 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bengtson BP AU - Baxter RA FA - Bengtson, Bradley P FA - Baxter, Richard A IN - Bengtson, Bradley P. Bengtson Center for Aesthetics and Plastic Surgery, 555 MidTowne Street NE, Grand Rapids, MI 49503, USA. drb@bengtsoncenter.com TI - Emerging applications for acellular dermal matrices in mastopexy. [Review] SO - Clinics in Plastic Surgery. 39(2):159-66, 2012 Apr AS - Clin Plast Surg. 39(2):159-66, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 159-66 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Skin, Artificial AB - This article explores whether some new acellular dermal matrices (ADMs) can be applied to breast augmentation or reconstruction revision, and particularly whether they can withstand the centripetal pull and prevent recurrent stretch deformities following periareolar mastopexy. Acellular dermis use in breast reconstruction and aesthetic breast revision is a fortuitous development, because their original purpose was for burn reconstruction. Although level 1 evidence remains lacking, ADMs have become integral adjuncts in breast reconstruction, complex hernia, and aesthetic breast revision. New applications continue to be explored, although these are in early stages of development and their long-term value remains to be confirmed. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.006 PT - Journal Article PT - Review ID - S0094-1298(12)00008-9 [pii] ID - 10.1016/j.cps.2012.02.006 [doi] PP - ppublish LG - English EP - 20120319 DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482357 <365. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482356 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Topol BM FA - Topol, Bruce M IN - Topol, Bruce M. Division of Plastic Surgery, The Elliot Hospital, Catholic Medical Center, 36 Bay Street, Manchester, NH 03104, USA. drtopol@drtopol.com TI - The use of human acellular dermal matrices in irradiated breast reconstruction. [Review] SO - Clinics in Plastic Surgery. 39(2):149-58, 2012 Apr AS - Clin Plast Surg. 39(2):149-58, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 149-58 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - Animals MH - *Breast Neoplasms/rt [Radiotherapy] MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Radiation Injuries/et [Etiology] MH - *Radiation Injuries/su [Surgery] MH - Skin, Artificial AB - This article examines the effects of radiation on prosthetic breast reconstruction when human dermal allograft is used in the reconstruction. A brief review of radiation terminology and techniques as applied to the breast is given, followed by a review of the effects of radiation on wound healing in human tissue. The effects of radiation on prosthetic breast reconstruction before the advent of dermal allografting are reviewed. The addition of dermal allograft in reconstruction has led to a reduced number of complications. An algorithm for surgical treatment of irradiated prosthetic breast reconstructions is presented, with a discussion of the authors technique. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.002 PT - Journal Article PT - Review ID - S0094-1298(12)00004-1 [pii] ID - 10.1016/j.cps.2012.02.002 [doi] PP - ppublish LG - English EP - 20120308 DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482356 <366. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482355 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kaufman D FA - Kaufman, David IN - Kaufman, David. Kaufman and Clark Plastic Surgery, 2220 East Bidwell Street, Folsom, CA 95630, USA. David@thenaturalresult.com TI - Pocket reinforcement using acellular dermal matrices in revisionary breast augmentation. [Review] SO - Clinics in Plastic Surgery. 39(2):137-48, 2012 Apr AS - Clin Plast Surg. 39(2):137-48, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 137-48 PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Reoperation MH - Skin, Artificial AB - Revision breast augmentation to treat implant malposition is fraught with challenges. This article focuses on treatment of implant malposition by using acellular dermal matrices (ADMs) with the intent of creating more reliable and accurate results. The article discusses the use of ADMs in patients with breast implant complications such as bottoming out, lateral implant displacement, or synmastia. ADM is a foreign material, thereby adding potential complications to consider. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.001 PT - Journal Article PT - Review ID - S0094-1298(12)00003-X [pii] ID - 10.1016/j.cps.2012.02.001 [doi] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482355 <367. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482354 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Namnoum JD AU - Moyer HR FA - Namnoum, James D FA - Moyer, Hunter R IN - Namnoum, James D. Atlanta Plastic Surgery, Emory University, 975 Johnson Ferry Road, Atlanta, GA 30319, USA. jdnamnoum@atlplastic.com TI - The role of acellular dermal matrix in the treatment of capsular contracture. SO - Clinics in Plastic Surgery. 39(2):127-36, 2012 Apr AS - Clin Plast Surg. 39(2):127-36, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 127-36 PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Contracture/et [Etiology] MH - *Contracture/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Skin, Artificial AB - Capsular contracture is one of the most common complications following breast surgery with implants and is a common cause for reoperation. Many techniques have been described to treat or prevent recurrent capsular contracture with varying success. Acellular dermal matrix (ADM), in combination with periprosthetic capsulectomy, is a powerful tool to delay or prevent recurrent contracture. Excellent results have been obtained when this approach has been used in patients with capsular contracture, but at increased cost. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.02.005 PT - Case Reports PT - Journal Article ID - S0094-1298(12)00007-7 [pii] ID - 10.1016/j.cps.2012.02.005 [doi] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482354 <368. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482353 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA FA - Salzberg, C Andrew IN - Salzberg, C Andrew. New York Medical College, Grasslands Road, Valhalla, NY 10591, USA. asalzbergmd@yahoo.com TI - Direct-to-implant breast reconstruction. [Review] SO - Clinics in Plastic Surgery. 39(2):119-26, 2012 Apr AS - Clin Plast Surg. 39(2):119-26, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 119-26 PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Nipples/su [Surgery] MH - *Surgical Flaps MH - *Tissue Expansion/mt [Methods] MH - Treatment Outcome AB - The expectations for improved results in postmastectomy reconstruction for women have increased in the past decade. The modified radical mastectomy has given way to breast conservation techniques using principles of skin preservation. Skin-sparing and nipple-sparing mastectomies have allowed plastic surgeons to perform breast reconstruction with the advantage of an intact skin envelope. Acellular dermal matrix is a biotechnological tissue prepared from either human or porcine skin. During processing, the cellular components that cause rejection and inflammation are removed, producing a structurally intact tissue matrix that serves as the biologic scaffold necessary for tissue ingrowth, angiogenesis, and tissue regeneration. Copyright © 2012 Elsevier Inc. All rights reserved. ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2012.01.001 PT - Journal Article PT - Review ID - S0094-1298(12)00002-8 [pii] ID - 10.1016/j.cps.2012.01.001 [doi] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482353 <369. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482352 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Draper LB AU - Disa JJ FA - Draper, Lawrence B FA - Disa, Joseph J IN - Draper, Lawrence B. Institute for Reconstructive Plastic Surgery, New York University School of Medicine, 1275 York Avenue, New York, NY 10065, USA. TI - Do acellularized dermal matrices change the rationale for immediate versus delayed breast reconstruction?. [Review] SO - Clinics in Plastic Surgery. 39(2):113-8, 2012 Apr AS - Clin Plast Surg. 39(2):113-8, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 113-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Skin, Artificial MH - Surgical Flaps MH - Time Factors MH - Tissue Expansion/mt [Methods] MH - Treatment Outcome AB - This article focuses on the contribution of acellular dermal matrices (ADMs) to immediate breast reconstruction. The current literature on ADMs is reviewed and the potential advantages and disadvantages of their use are highlighted. Technical considerations on how to effectively use these materials is presented. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2011.12.002 PT - Journal Article PT - Review ID - S0094-1298(11)00217-3 [pii] ID - 10.1016/j.cps.2011.12.002 [doi] PP - ppublish LG - English EP - 20120121 DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482352 <370. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22482351 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Baxter RA FA - Baxter, Richard A IN - Baxter, Richard A. Plastic Surgery Clinic, 6100 219th Street SW, Mountlake Terrace, WA 98043, USA. drbaxter@drbaxter.com TI - Acellular dermal matrices in breast implant surgery: defining the problem and proof of concept. SO - Clinics in Plastic Surgery. 39(2):103-12, 2012 Apr AS - Clin Plast Surg. 39(2):103-12, 2012 Apr NJ - Clinics in plastic surgery VO - 39 IP - 2 PG - 103-12 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - Adult MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Skin, Artificial MH - *Surgical Flaps MH - *Tissue Expansion/mt [Methods] AB - The use of acellular dermal matrices (ADMs) has become a useful adjunct to implant-based breast reconstruction and revision of the augmented breast. In both instances, the goal is replacement or reinforcement of thinned or missing tissues for implant support and control of the implant pocket. This article reviews the factors that contribute to periprosthetic tissue thinning, and the advantages and limitations of the use of ADMs for revision breast surgery and breast reconstruction. Proof of concept for the use of ADMs in the periprosthetic space is detailed from early clinical experience and histologic analysis documenting vascular ingrowth and cellular repopulation. Copyright © 2012 Elsevier Inc. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2011.12.001 PT - Case Reports PT - Journal Article ID - S0094-1298(11)00216-1 [pii] ID - 10.1016/j.cps.2011.12.001 [doi] PP - ppublish LG - English EP - 20120127 DP - 2012 Apr EZ - 2012/04/10 06:00 DA - 2012/08/01 06:00 DT - 2012/04/10 06:00 YR - 2012 ED - 20120731 RD - 20120409 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22482351 <371. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22544089 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Butler CE AU - Selber JC FA - Butler, Charles E FA - Selber, Jesse C IN - Butler, Charles E. Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA. cbutler@mdanderson.org TI - Discussion: the use of acellular dermal matrix in immediate two-stage tissue expander breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2012 May;129(5):1049-58; PMID: 22544088 SO - Plastic & Reconstructive Surgery. 129(5):1059-60, 2012 May AS - Plast Reconstr Surg. 129(5):1059-60, 2012 May NJ - Plastic and reconstructive surgery VO - 129 IP - 5 PG - 1059-60 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Implantation/ae [Adverse Effects] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mastectomy MH - *Tissue Expansion/ae [Adverse Effects] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31824a29dc PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e31824a29dc [doi] ID - 00006534-201205000-00006 [pii] PP - ppublish LG - English DP - 2012 May EZ - 2012/05/01 06:00 DA - 2012/06/26 06:00 DT - 2012/05/01 06:00 YR - 2012 ED - 20120625 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22544089 <372. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22544088 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Weichman KE AU - Wilson SC AU - Weinstein AL AU - Hazen A AU - Levine JP AU - Choi M AU - Karp NS FA - Weichman, Katie E FA - Wilson, Stelios C FA - Weinstein, Andrew L FA - Hazen, Alexes FA - Levine, Jamie P FA - Choi, Mihye FA - Karp, Nolan S IN - Weichman, Katie E. New York University Langone Medical Center, Institute of Reconstructive Plastic Surgery, New York, NY, USA. TI - The use of acellular dermal matrix in immediate two-stage tissue expander breast reconstruction. CM - Comment in: Plast Reconstr Surg. 2012 May;129(5):1059-60; PMID: 22544089 SO - Plastic & Reconstructive Surgery. 129(5):1049-58, 2012 May AS - Plast Reconstr Surg. 129(5):1049-58, 2012 May NJ - Plastic and reconstructive surgery VO - 129 IP - 5 PG - 1049-58 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Breast Implantation/ae [Adverse Effects] MH - Breast Implants/ae [Adverse Effects] MH - Breast Neoplasms/pc [Prevention & Control] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/ae [Adverse Effects] MH - Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - *Mastectomy MH - Middle Aged MH - Retrospective Studies MH - *Tissue Expansion/ae [Adverse Effects] MH - Tissue Expansion Devices/ae [Adverse Effects] AB - BACKGROUND: Acellular dermal matrix is commonly used in implant-based breast reconstruction to allow for quicker tissue expansion with better coverage and definition of the lower pole of the breast. This study was performed to analyze complications associated with its use in immediate two-stage, implant-based breast reconstruction and to subsequently develop guidelines for its use. AB - METHODS: A retrospective analysis of 628 consecutive immediate two-stage tissue expander breast reconstructions at a single institution over a 3-year period was conducted. The reconstructions were divided into two groups: reconstruction with acellular dermal matrix and reconstruction without it. Demographic information, patient characteristics, surface area of acellular dermal matrix, and complications were analyzed and compared. AB - RESULTS: A total of 407 patients underwent 628 immediate two-stage, implant-based breast reconstructions; 442 reconstructions (70.3 percent) used acellular dermal matrix and 186 (29.6 percent) did not. The groups had similar patient characteristics; however, major complications were significantly increased in the acellular dermal matrix group (15.3 versus 5.4 percent; p = 0.001). These complications included infection requiring intravenous antibiotics (8.6 versus 2.7 percent; p = 0.001), flap necrosis requiring excision (6.7 versus 2.7 percent; p = 0.015), and explantation of the tissue expander (7.7 versus 2.7 percent; p = 0.004). AB - CONCLUSIONS: Use of acellular dermal matrix in immediate two-stage, implant-based breast cancer reconstruction is associated with a significant increase in major complications. Therefore, it should only be used in specific patients and in minimal amounts. Indications for its use include single-stage permanent implant reconstruction and inadequate local muscle coverage of the tissue expander. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31824a2acb PT - Journal Article ID - 10.1097/PRS.0b013e31824a2acb [doi] ID - 00006534-201205000-00005 [pii] PP - ppublish LG - English DP - 2012 May EZ - 2012/05/01 06:00 DA - 2012/06/26 06:00 DT - 2012/05/01 06:00 YR - 2012 ED - 20120625 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22544088 <373. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22421476 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ho G AU - Nguyen TJ AU - Shahabi A AU - Hwang BH AU - Chan LS AU - Wong AK FA - Ho, Goretti FA - Nguyen, T JoAnna FA - Shahabi, Ahva FA - Hwang, Brian H FA - Chan, Linda S FA - Wong, Alex K IN - Ho, Goretti. Division of Plastic and Reconstructive Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA. TI - A systematic review and meta-analysis of complications associated with acellular dermal matrix-assisted breast reconstruction. [Review] CM - Comment in: Aesthetic Plast Surg. 2017 Apr;41(2):282-283; PMID: 28233127 SO - Annals of Plastic Surgery. 68(4):346-56, 2012 Apr AS - Ann Plast Surg. 68(4):346-56, 2012 Apr NJ - Annals of plastic surgery VO - 68 IP - 4 PG - 346-56 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Implants/ae [Adverse Effects] MH - Cellulitis/ep [Epidemiology] MH - Cellulitis/et [Etiology] MH - Contracture/ep [Epidemiology] MH - Contracture/et [Etiology] MH - Female MH - Graft Rejection MH - Hematoma/ep [Epidemiology] MH - Hematoma/et [Etiology] MH - Humans MH - Incidence MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Middle Aged MH - *Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pa [Pathology] MH - Prognosis MH - Risk Assessment MH - Seroma/ep [Epidemiology] MH - Seroma/et [Etiology] MH - *Skin Transplantation/ae [Adverse Effects] MH - Skin Transplantation/mt [Methods] MH - *Skin, Artificial/ae [Adverse Effects] MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/pa [Pathology] MH - Tissue Expansion/mt [Methods] MH - United States AB - BACKGROUND: Multiple outcome studies have been published on the use of acellular dermal matrix (ADM) in breast reconstruction with disparate results. The purpose of this study was to conduct a systematic review and meta-analysis to determine an aggregate estimate of risks associated with ADM-assisted breast reconstruction. AB - METHODS: The MEDLINE, Web of Science, and Cochrane Library databases were queried, and relevant articles published up to September 2010 were analyzed based on specific inclusion criteria. Seven complications were studied including seroma, cellulitis, infection, hematoma, skin flap necrosis, capsular contracture, and reconstructive failure. A pooled random effects estimate for each complication and 95% confidence intervals (CI) were derived. For comparisons of ADM and non-ADM, the pooled random effects odds ratio (OR) and 95% CI were derived. Heterogeneity was measured using the I2 statistic. AB - RESULTS: Sixteen studies met the inclusion criteria. The pooled complication rates were seroma (6.9%; 95% CI, 5.3%-8.8%), cellulitis (2.0%; 95% CI, 1.2%-3.1%), infection (5.7%; 95% CI, 4.3%-7.3%), skin flap necrosis (10.9%; 95% CI, 8.7%-13.5%), hematoma (1.3%; 95% CI, 0.6%-2.4%), capsular contracture (0.6%; 95% CI, 0.1%-1.7%), and reconstructive failure (5.1%; 95% CI, 3.8%-6.7%). Five studies reported findings for both the ADM and non-ADM patients and were used in the meta-analysis to calculate pooled OR. ADM-assisted breast reconstructions had a higher likelihood of seroma (pooled OR, 3.9; 95% CI, 2.4-6.2), infection (pooled OR, 2.7; 95% CI, 1.1-6.4), and reconstructive failure (pooled OR, 3.0; 95% CI, 1.3-6.8) than breast reconstructions without the use of ADM. The relation of ADM use to hematoma (pooled OR, 2.0; 95% CI, 0.8-5.2), cellulitis (pooled OR, 2.0; 95% CI, 0.9-4.3), and skin flap necrosis (pooled OR, 1.9; 95% CI, 0.6-5.4) was inconclusive. AB - CONCLUSIONS: In the studies evaluated, ADM-assisted breast reconstructions exhibited a higher likelihood of seroma, infection, and reconstructive failure than prosthetic-based breast reconstructions using traditional musculofascial flaps. ADM is associated with a lower rate of capsular contracture. A careful risk/benefit analysis should be performed when choosing to use ADM in implant-based breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31823f3cd9 PT - Journal Article PT - Meta-Analysis PT - Review ID - 10.1097/SAP.0b013e31823f3cd9 [doi] ID - 00000637-201204000-00005 [pii] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/03/17 06:00 DA - 2012/06/26 06:00 DT - 2012/03/17 06:00 YR - 2012 ED - 20120625 RD - 20170825 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22421476 <374. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22421474 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Endress R AU - Choi MS AU - Lee GK FA - Endress, Ryan FA - Choi, M Seung Suk FA - Lee, Gordon K IN - Endress, Ryan. Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA, USA. TI - Use of fetal bovine acellular dermal xenograft with tissue expansion for staged breast reconstruction. SO - Annals of Plastic Surgery. 68(4):338-41, 2012 Apr AS - Ann Plast Surg. 68(4):338-41, 2012 Apr NJ - Annals of plastic surgery VO - 68 IP - 4 PG - 338-41 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Animals MH - Biocompatible Materials MH - Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Cattle MH - Cohort Studies MH - Esthetics MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Care/mt [Methods] MH - Postoperative Complications/pp [Physiopathology] MH - Retrospective Studies MH - *Skin Transplantation/mt [Methods] MH - *Tissue Expansion/mt [Methods] MH - Transplantation, Heterologous/ae [Adverse Effects] MH - *Transplantation, Heterologous/mt [Methods] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] MH - Young Adult AB - INTRODUCTION: Staged breast reconstruction with implants and human acellular cadaveric dermis offers advantages of precise expander positioning, higher initial expander fill volumes, and improved outcomes. This study reports breast reconstruction using fetal bovine acellular dermal matrix (FBADM). The high type III collagen content of FBADM may allow for more rapid tissue incorporation and healing. AB - METHODS: A total of 49 breast reconstructions in 28 patients (group A) with FBADM were retrospectively compared with 123 reconstructions in 91 patients operated without FBADM (group B). AB - RESULTS: FBADM sizes ranged from 48 to 100 cm2 (mean size: 70.6 cm2). The mean immediate fill volume in group A was 181.2 +/- 148.3 mL and 117.7 +/- 66.3 mL in group B (P < 0.001). The duration of drainage was significantly shorter in group A (8.51 +/- 3.4 days) as compared with controls (11.07 +/- 5.1 days), t-test (P = 0.015). There was no significant difference in the overall complication rate (20.8% in group A, 13.0% in group B). Further subgroup analysis of group A patients with complications and without complications, showed that group with complications had significantly longer drain removal time (9.48 vs. 7.97 days), larger initial fill volumes (238.1 vs. 145.3 mL), and a higher BMI (25.8 vs. 22.6 kg/m2) when compared with the complication-free subgroup. AB - CONCLUSIONS: The use of FBADM in breast reconstruction offers results comparable with that of human acellular dermal matrix as reported in the literature. However, FBADM significantly reduced wound drainage time in our study when compared with patients without FBADM. RN - 0 (Biocompatible Materials) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31823b68d0 PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0b013e31823b68d0 [doi] ID - 00000637-201204000-00003 [pii] PP - ppublish LG - English DP - 2012 Apr EZ - 2012/03/17 06:00 DA - 2012/06/26 06:00 DT - 2012/03/17 06:00 YR - 2012 ED - 20120625 RD - 20120316 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22421474 <375. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21862920 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cicilioni O Jr AU - Araujo G AU - Mimbs N AU - Cox MD FA - Cicilioni, Orlando Jr FA - Araujo, Gerson FA - Mimbs, Nancy FA - Cox, Matthew D IN - Cicilioni, Orlando Jr. Department of Plastic Surgery for Florida Hospital, 2501 North Orange Avenue, Orlando, FL 32804, USA. ocicilioni@aol.com TI - Initial experience with the use of porcine acellular dermal matrix (Strattice) for abdominal wall reinforcement after transverse rectus abdominis myocutaneous flap breast reconstruction. SO - Annals of Plastic Surgery. 68(3):265-70, 2012 Mar AS - Ann Plast Surg. 68(3):265-70, 2012 Mar NJ - Annals of plastic surgery VO - 68 IP - 3 PG - 265-70 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Abdominal Muscles/su [Surgery] MH - *Abdominal Wall/su [Surgery] MH - Animals MH - *Collagen/tu [Therapeutic Use] MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Middle Aged MH - Muscle Weakness/et [Etiology] MH - *Muscle Weakness/su [Surgery] MH - Postoperative Complications/cl [Classification] MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Retrospective Studies MH - *Surgical Flaps/ae [Adverse Effects] MH - Suture Techniques MH - Swine AB - Reestablishing anterior rectus fascial integrity remains a clinical challenge after transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction. The main concerns include herniation and bulging due to abdominal weakness. Mesh-assisted closure of the fascial defect has improved bulging and herniation rates but infection, extrusion, and encapsulation are serious concerns with mesh use. Biologic tissue matrices may overcome some of these mesh-related complications. The initial experience of using Strattice for fascial closure after TRAM flap procedure is described in this article. Strattice was in-lain and sutured between the anterior and posterior layers of the rectus fascia, at the rectus muscle donor site. The abdominal wall was closed with progressive tension sutures. Postoperative complications at the donor site were assessed. A total of 16 unilateral and 9 bilateral reconstructions were performed in 25 patients. Length of hospital stay was 2 to 3 days which is shorter than with mesh repair (typically 4-5 days). During a mean follow-up period of 14.0 months, complications occurred in 7 patients (28%): seroma formation (2), minor skin separation (2), superficial skin infection (2), and superficial wound dehiscence (1). Complications were not directly related to Strattice and all, except one (superficial skin infection), were resolved without surgical intervention. In all patients, routine abdominal functions were restored 4 months postoperatively. Strattice is a safe, alternative option to synthetic mesh for fascial repair following TRAM flap breast reconstruction. When used in conjunction with progressive tension suture closure of the abdominal wall, dynamic reconstruction of the abdominal wall with resumption of abdominal function is possible with Strattice. RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31822af89d PT - Journal Article ID - 10.1097/SAP.0b013e31822af89d [doi] PP - ppublish LG - English DP - 2012 Mar EZ - 2011/08/25 06:00 DA - 2012/06/19 06:00 DT - 2011/08/25 06:00 YR - 2012 ED - 20120618 RD - 20120223 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21862920 <376. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21607537 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Parikh RP AU - Pappas-Politis E AU - Smith PD FA - Parikh, Rajiv P FA - Pappas-Politis, Effie FA - Smith, Paul D IN - Parikh, Rajiv P. Division of Plastic Surgery, Department of Surgery, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 2, Tampa, FL 33612, USA. rajpparikh@gmail.com TI - Acellular dermal matrix masking detection of recurrent breast carcinoma: a novel complication. SO - Aesthetic Plastic Surgery. 36(1):149-52, 2012 Feb AS - Aesthetic Plast Surg. 36(1):149-52, 2012 Feb NJ - Aesthetic plastic surgery VO - 36 IP - 1 PG - 149-52 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Biocompatible Materials MH - Breast/su [Surgery] MH - *Breast Implantation/ae [Adverse Effects] MH - *Breast Neoplasms/di [Diagnosis] MH - Breast Neoplasms/su [Surgery] MH - *Carcinoma, Ductal, Breast/di [Diagnosis] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - *Diagnostic Errors MH - Female MH - Humans MH - *Neoplasm Recurrence, Local/di [Diagnosis] MH - *Skin, Artificial/ae [Adverse Effects] AB - Acellular dermal matrix (ADM) use in prosthetic breast reconstruction has become increasingly popular. Several benefits have been reported with this technique including diminished donor-site morbidity and improved aesthetic outcomes. Recently, in an effort to ascertain the overall safety and efficacy of this approach, an emphasis has been placed on identifying potential postoperative complications. This report describes a unique complication experienced with ADM use in which ADM conceals the detection of recurrent breast carcinoma. RN - 0 (Biocompatible Materials) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-011-9744-6 PT - Case Reports PT - Journal Article ID - 10.1007/s00266-011-9744-6 [doi] PP - ppublish PH - 2011/03/16 [received] PH - 2011/04/21 [accepted] LG - English EP - 20110524 DP - 2012 Feb EZ - 2011/05/25 06:00 DA - 2012/06/19 06:00 DT - 2011/05/25 06:00 YR - 2012 ED - 20120618 RD - 20120302 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21607537 <377. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22157603 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gabriel A AU - Maxwell GP FA - Gabriel, Allen FA - Maxwell, G Patrick IN - Gabriel, Allen. Department of Surgery, Southwest Washington Medical Center, Vancouver, WA, USA. gabrielallen@yahoo.com TI - Evolving role of alloderm in breast surgery. [Review] SO - Plastic Surgical Nursing. 31(4):141-50, 2011 Oct-Dec AS - Plast Surg Nurs. 31(4):141-50, 2011 Oct-Dec NJ - Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses VO - 31 IP - 4 PG - 141-50 PI - Journal available in: Print PI - Citation processed from: Internet JC - 8403490, p8m IO - Plast Surg Nurs SB - Nursing Journal CP - United States MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty MH - Mastectomy AB - The adjunctive use of acellular dermal matrices in breast surgery is expanding. The purpose of this article is to provide an overview of the various applications of acellular dermal matrices in breast surgery, the benefits and complications associated with their use, and best practices to optimize outcomes using a human acellular dermal matrix (AlloDerm [LifeCell Corp., Branchburg, NJ]) as an example. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1550-1841 IL - 0741-5206 DO - https://dx.doi.org/10.1097/PSN.0b013e31823b2c30 PT - Journal Article PT - Review ID - 10.1097/PSN.0b013e31823b2c30 [doi] ID - 00006527-201110000-00004 [pii] PP - ppublish LG - English DP - 2011 Oct-Dec EZ - 2011/12/14 06:00 DA - 2012/06/01 06:00 DT - 2011/12/14 06:00 YR - 2011 ED - 20120531 RD - 20111214 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22157603 <378. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22374028 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Seaman BJ AU - Akbari SR AU - Davison SP FA - Seaman, Bradley J FA - Akbari, Stephanie R FA - Davison, Steven P TI - A novel technique for nipple-areola complex reconstruction: the acellular dermal matrix onlay graft. SO - Plastic & Reconstructive Surgery. 129(3):580e-581e, 2012 Mar AS - Plast Reconstr Surg. 129(3):580e-581e, 2012 Mar NJ - Plastic and reconstructive surgery VO - 129 IP - 3 PG - 580e-581e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Nipples/su [Surgery] MH - *Skin, Artificial RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182419c68 PT - Editorial ID - 10.1097/PRS.0b013e3182419c68 [doi] ID - 00006534-201203000-00074 [pii] PP - ppublish LG - English DP - 2012 Mar EZ - 2012/03/01 06:00 DA - 2012/04/24 06:00 DT - 2012/03/01 06:00 YR - 2012 ED - 20120423 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22374028 <379. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22286439 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kobraei EM AU - Nimtz J AU - Wong L AU - Buseman J AU - Kemper P AU - Wright H AU - Rinker BD FA - Kobraei, Edward M FA - Nimtz, Jared FA - Wong, Lesley FA - Buseman, Jason FA - Kemper, Pamela FA - Wright, Heather FA - Rinker, Brian D IN - Kobraei, Edward M. University of Kentucky College of Medicine, Lexington, KY, USA. TI - Risk factors for adverse outcome following skin-sparing mastectomy and immediate prosthetic reconstruction. CM - Comment in: Plast Reconstr Surg. 2012 Oct;130(4):613e-614e; author reply 614e-615e; PMID: 23018724 SO - Plastic & Reconstructive Surgery. 129(2):234e-241e, 2012 Feb AS - Plast Reconstr Surg. 129(2):234e-241e, 2012 Feb NJ - Plastic and reconstructive surgery VO - 129 IP - 2 PG - 234e-241e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implantation/ae [Adverse Effects] MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Mastectomy/ae [Adverse Effects] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Retrospective Studies MH - Risk Factors MH - Skin MH - Time Factors AB - BACKGROUND: Attempts to identify risk factors for adverse outcome following skin-sparing mastectomy and immediate prosthetic reconstruction have yielded inconsistent results, and no clear patient selection criteria have emerged. The authors identified patient- and procedure-related characteristics that predict unfavorable postoperative outcomes. Knowledge of these risk factors will facilitate preoperative patient screening to reduce the rate of implant loss and other postoperative complications. AB - METHODS: The authors retrospectively evaluated the postoperative outcomes of implant loss and major and minor complications in 102 patients (155 breasts) undergoing the combined operation from January of 2005 to December of 2010. Univariate logistic regression analysis was performed to determine the influence of six patient-related and three procedure-related characteristics on implant loss and postoperative complications. AB - RESULTS: The use of acellular dermis was associated with a greater than three-fold increased risk of postoperative complications. Radiotherapy exposure was found to have a significant association with implant loss. None of the patient-related characteristics studied behaved as risk factors for postoperative complications, and none of the procedure-related characteristics acted as risk factors for implant loss. AB - CONCLUSIONS: A cautious and conservative approach to using acelluar dermal matrix in this setting is warranted until its effect on postoperative outcomes is more clearly defined. The authors' data support findings from other studies of the deleterious effect of breast radiotherapy on postoperative outcomes. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, IV. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31823aec7f PT - Journal Article ID - 10.1097/PRS.0b013e31823aec7f [doi] ID - 00006534-201202000-00012 [pii] PP - ppublish LG - English DP - 2012 Feb EZ - 2012/01/31 06:00 DA - 2012/03/20 06:00 DT - 2012/01/31 06:00 YR - 2012 ED - 20120319 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22286439 <380. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22186542 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Larcher L AU - Helml GH AU - Huemer GM FA - Larcher, Lorenz FA - Helml, Gudrun H FA - Huemer, Georg M TI - An easy method of acellular dermal matrix fixation to the submammary fold in prosthetic breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2011 May;127(5):1755-62; PMID: 21228744 SO - Plastic & Reconstructive Surgery. 129(1):170e-171e; author reply 171e-172e, 2012 Jan AS - Plast Reconstr Surg. 129(1):170e-171e; author reply 171e-172e, 2012 Jan NJ - Plastic and reconstructive surgery VO - 129 IP - 1 PG - 170e-171e; author reply 171e-172e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Collagen/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - *Postoperative Complications/ep [Epidemiology] RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182362dfe PT - Comment PT - Letter ID - 10.1097/PRS.0b013e3182362dfe [doi] ID - 00006534-201201000-00070 [pii] PP - ppublish LG - English DP - 2012 Jan EZ - 2011/12/22 06:00 DA - 2012/03/07 06:00 DT - 2011/12/22 06:00 YR - 2012 ED - 20120306 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22186542 <381. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22186498 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kim JY AU - Davila AA AU - Persing S AU - Connor CM AU - Jovanovic B AU - Khan SA AU - Fine N AU - Rawlani V FA - Kim, John Y S FA - Davila, Armando A FA - Persing, Scott FA - Connor, Caitlin M FA - Jovanovic, Borko FA - Khan, Seema A FA - Fine, Neil FA - Rawlani, Vinay IN - Kim, John Y S. Division of Plastic and Reconstructive Surgery, Department of Preventative Medicine, and the Lynn Sage Breast Center, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA. jokim@nmh.org TI - A meta-analysis of human acellular dermis and submuscular tissue expander breast reconstruction. CM - Comment in: Plast Reconstr Surg. 2012 Aug;130(2):359e-361e; author reply 361e-362e; PMID: 22842432 CM - Comment in: Plast Reconstr Surg. 2012 Dec;130(6):896e; author reply 896e-898e; PMID: 23190846 SO - Plastic & Reconstructive Surgery. 129(1):28-41, 2012 Jan AS - Plast Reconstr Surg. 129(1):28-41, 2012 Jan NJ - Plastic and reconstructive surgery VO - 129 IP - 1 PG - 28-41 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Biocompatible Materials MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Skin, Artificial MH - *Tissue Expansion Devices AB - BACKGROUND: Human acellular dermal matrix has become an increasingly used adjunct to traditional submuscular tissue expander/implant breast reconstruction, but there is no strong consensus regarding complication outcomes. This study stratified outcomes based on a meta-analysis of complications. AB - METHODS: A query of the MEDLINE database for articles on human acellular dermal matrix and submuscular tissue expander breast reconstruction yielded 901 citations. Two levels of screening identified 48 relevant studies. The DerSimonian and Laird random-effects model was used to perform the meta-analysis. Risk ratios and pooled complication rates were calculated for each outcome of interest. AB - RESULTS: Nineteen studies reporting human acellular dermal matrix (n = 2037) and 35 reporting submuscular outcomes (n = 12,847) were used to estimate complication rates. Rates were generally higher in acellular dermis patients: total complications, 15.4 versus 14.0 percent; seroma, 4.8 versus 3.5 percent; infection, 5.3 versus 4.7 percent; and flap necrosis, 6.9 versus 4.9 percent. Six studies reporting both acellular dermis and submuscular outcomes were used to estimate relative risks. There was an increased risk of total complications (relative risk, 2.05; 95 percent CI, 1.55 to 2.70), seroma (relative risk, 2.73; 95 percent CI, 1.67 to 4.46), infection (relative risk, 2.47; 95 percent CI, 1.71 to 3.57), and reconstructive failure (relative risk, 2.80; 95 percent CI, 1.76 to 4.45) in acellular dermis patients. AB - CONCLUSIONS: The meta-analysis suggests that the use of human acellular dermal matrix increases complication rates vis-a-vis submuscular expander/implant reconstruction. This must be weighed against its reported advantages in enhancing cosmesis and ameliorating contracture. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: : Therapeutic, III. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182361fd6 PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e3182361fd6 [doi] ID - 00006534-201201000-00009 [pii] PP - ppublish LG - English DP - 2012 Jan EZ - 2011/12/22 06:00 DA - 2012/03/07 06:00 DT - 2011/12/22 06:00 YR - 2012 ED - 20120306 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22186498 <382. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21908827 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Shestak KC FA - Shestak, Kenneth C IN - Shestak, Kenneth C. Plastic Surgery Service at Magee-Womens Hospital, Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 5213, USA. shestakkc@upmc.edu TI - Acellular dermal matrix inlays to correct significant implant malposition in patients with compromised local tissues. SO - Aesthetic Surgery Journal. 31(7 Suppl):85S-94S, 2011 Sep AS - Aesthet. surg. j.. 31(7 Suppl):85S-94S, 2011 Sep NJ - Aesthetic surgery journal VO - 31 IP - 7 Suppl PG - 85S-94S PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Adult MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants/ae [Adverse Effects] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Middle Aged MH - Reoperation MH - Retrospective Studies AB - Breast implant malposition is an increasingly recognized complication of breast augmentation and implant-based breast reconstruction. Etiologic factors include technical imprecision during surgery with overdissection or inadequate dissection of the pocket, inappropriately large implant selection, and the compromise of the local breast tissues, which produces an inability of a patient's natural tissues to support an implant in the placed position. In this article, the author describes a series of 19 patients with significant breast implant malposition following staged implant breast reconstruction in the setting of locally compromised tissues. Given the results, the author believes that an effective technique in the correction of severe implant malposition is reconfiguration and reconstruction of the periprosthetic capsular space, with a combination of focal "mirror image" capsule excision and permanent suture repair to restore breast folds, along with an acellular dermal matrix inlay technique designed to confer structural support to this repair. This strategy merits consideration in patients who have significant implant malposition in the face of severely compromised local breast tissues. RN - 0 (Alloderm) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11418337 PT - Case Reports PT - Journal Article ID - 31/7_suppl/85S [pii] ID - 10.1177/1090820X11418337 [doi] PP - ppublish LG - English DP - 2011 Sep EZ - 2011/09/23 06:00 DA - 2012/01/20 06:00 DT - 2011/09/13 06:00 YR - 2011 ED - 20120119 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21908827 <383. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21908826 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mofid MM FA - Mofid, M Mark IN - Mofid, M Mark. Division of Plastic Surgery, University of California, San Diego, California, USA. drmofid@mofidplasticsurgery.com TI - Acellular dermal matrix in cosmetic breast procedures and capsular contracture. [Review] SO - Aesthetic Surgery Journal. 31(7 Suppl):77S-84S, 2011 Sep AS - Aesthet. surg. j.. 31(7 Suppl):77S-84S, 2011 Sep NJ - Aesthetic surgery journal VO - 31 IP - 7 Suppl PG - 77S-84S PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Animals MH - Biocompatible Materials/tu [Therapeutic Use] MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Implant Capsular Contracture/pa [Pathology] MH - *Implant Capsular Contracture/su [Surgery] AB - Prevention and treatment of capsular contracture after breast augmentation is a controversial and oftentimes vexing problem. While there are traditional methods of addressing this condition, acellular dermal matrix materials offer a new and promising modality that is gaining momentum in the field of plastic surgery. In this article, the author examines the etiology and pathophysiology of capsular contracture and review the existing literature on acellular dermal matrix in breast surgery related to capsular contracture. RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11418201 PT - Journal Article PT - Review ID - 31/7_suppl/77S [pii] ID - 10.1177/1090820X11418201 [doi] PP - ppublish LG - English DP - 2011 Sep EZ - 2011/09/23 06:00 DA - 2012/01/20 06:00 DT - 2011/09/13 06:00 YR - 2011 ED - 20120119 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21908826 <384. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21908825 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, California, USA. TI - Acellular dermal matrix in aesthetic revisionary breast surgery. SO - Aesthetic Surgery Journal. 31(7 Suppl):65S-76S, 2011 Sep AS - Aesthet. surg. j.. 31(7 Suppl):65S-76S, 2011 Sep NJ - Aesthetic surgery journal VO - 31 IP - 7 Suppl PG - 65S-76S PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Biocompatible Materials/tu [Therapeutic Use] MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - *Breast Implants MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Implant Capsular Contracture/su [Surgery] MH - Postoperative Complications MH - Reoperation/mt [Methods] AB - Breast augmentation is one of the most commonly-performed cosmetic procedures worldwide. Unfortunately, many women require revisionary surgery related to unsatisfactory results or complications such as capsular contracture, implant malposition, and ptosis. While, historically, surgeons have relied on often-imperfect native tissue to correct these deformities, acellular dermal matrix (ADM) offers a new option for solving these difficult aesthetic problems. In this article, the authors provide background information about the role of ADM in providing excellent and lasting results to cosmetic breast augmentation patients, and they describe their method of subpectoral revisionary augmentation with ADM. RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11418333 PT - Journal Article ID - 31/7_suppl/65S [pii] ID - 10.1177/1090820X11418333 [doi] PP - ppublish LG - English DP - 2011 Sep EZ - 2011/09/23 06:00 DA - 2012/01/20 06:00 DT - 2011/09/13 06:00 YR - 2011 ED - 20120119 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21908825 <385. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21908824 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Israeli R AU - Feingold RS FA - Israeli, Ron FA - Feingold, Randall S IN - Israeli, Ron. Division of Plastic Surgery, Department of Surgery, Hofstra University School of Medicine, in partnership with North Shore-LIJ Health System, Hempstead, New York, USA. risraeli@bodyplasticsurgery.com TI - Acellular dermal matrix in breast reconstruction in the setting of radiotherapy. [Review] SO - Aesthetic Surgery Journal. 31(7 Suppl):51S-64S, 2011 Sep AS - Aesthet. surg. j.. 31(7 Suppl):51S-64S, 2011 Sep NJ - Aesthetic surgery journal VO - 31 IP - 7 Suppl PG - 51S-64S PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Animals MH - Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Mammaplasty/mt [Methods] MH - Radiotherapy, Adjuvant/mt [Methods] AB - Acellular dermal matrices (ADM) are becoming an integral component of immediate implant-based breast reconstruction, providing inferolateral coverage and support of the implant. Currently, five ADM products are available on the market for this purpose. Although their application has resulted in improved aesthetic results with low complication rates, the clinical performance of ADM when radiotherapy is a component of breast cancer treatment has yet to be defined. In this article, we present a thorough review of the current literature on the performance of ADM in the setting of radiotherapy from both animal and human studies, including our own experience with two proprietary ADM products. The other three products have little literature documenting their application for this type of reconstruction, and further studies specifically evaluating the performance of all ADM formulations in the setting of radiotherapy are still needed. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11418089 PT - Journal Article PT - Review ID - 31/7_suppl/51S [pii] ID - 10.1177/1090820X11418089 [doi] PP - ppublish LG - English DP - 2011 Sep EZ - 2011/09/23 06:00 DA - 2012/01/20 06:00 DT - 2011/09/13 06:00 YR - 2011 ED - 20120119 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21908824 <386. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21908823 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY AU - Spear SL FA - Nahabedian, Maurice Y FA - Spear, Scott L IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. DrNahabedian@aol.com TI - Acellular dermal matrix for secondary procedures following prosthetic breast reconstruction. [Review] SO - Aesthetic Surgery Journal. 31(7 Suppl):38S-50S, 2011 Sep AS - Aesthet. surg. j.. 31(7 Suppl):38S-50S, 2011 Sep NJ - Aesthetic surgery journal VO - 31 IP - 7 Suppl PG - 38S-50S PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implantation/mt [Methods] MH - Breast Implants/ae [Adverse Effects] MH - Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Nipples/su [Surgery] MH - Patient Selection AB - Acellular dermal matrices (ADM) have generated interest for their possible applications in secondary revisions following prosthetic breast reconstruction. These materials can be effective in a variety of situations, including implant displacement, synmastia, capsular contracture, incisional support, and pocket conversion. ADM can also be placed in the setting of delayed breast reconstruction and to augment nipple projection. These biomaterials have demonstrated feasibility and success for many complex deformities. However, there is an associated learning curve that includes an understanding of proper technique and patient selection. The authors review their cumulative experience between 2004 and 2010 with ADM for the correction of secondary deformities following prosthetic breast reconstruction, focusing on the indications for repair, traditional management, and management with ADM. RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11418093 PT - Journal Article PT - Review ID - 31/7_suppl/38S [pii] ID - 10.1177/1090820X11418093 [doi] PP - ppublish LG - English DP - 2011 Sep EZ - 2011/09/23 06:00 DA - 2012/01/20 06:00 DT - 2011/09/13 06:00 YR - 2011 ED - 20120119 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21908823 <387. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21908822 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H AU - Langstein HN FA - Sbitany, Hani FA - Langstein, Howard N IN - Sbitany, Hani. Division of Plastic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. Hani.Sbitany@gmail.com TI - Acellular dermal matrix in primary breast reconstruction. [Review] SO - Aesthetic Surgery Journal. 31(7 Suppl):30S-7S, 2011 Sep AS - Aesthet. surg. j.. 31(7 Suppl):30S-7S, 2011 Sep NJ - Aesthetic surgery journal VO - 31 IP - 7 Suppl PG - 30S-7S PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Animals MH - *Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implantation/mt [Methods] MH - Breast Implants MH - Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] AB - The use of acellular dermal matrix (ADM) in many plastic surgery procedures, including breast reconstruction, has increased dramatically in recent years. While expander/implant reconstruction can be performed successfully with standard techniques, the introduction of ADM has added a new tool with which to achieve lasting, predictable results. This article is a summary of existing literature on ADM for primary implant reconstruction, to provide a more thorough understanding of the benefits of ADM in single- and to two-stage breast reconstruction and to identify the areas where further investigation is needed. RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11417577 PT - Journal Article PT - Review ID - 31/7_suppl/30S [pii] ID - 10.1177/1090820X11417577 [doi] PP - ppublish LG - English DP - 2011 Sep EZ - 2011/09/23 06:00 DA - 2012/01/20 06:00 DT - 2011/09/13 06:00 YR - 2011 ED - 20120119 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21908822 <388. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21664204 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Flurry M AU - Natoli NB AU - Mesa JM AU - Moyer KE FA - Flurry, M FA - Natoli, N B FA - Mesa, J M FA - Moyer, K E IN - Flurry, M. Division of Plastic & Reconstructive Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA. TI - Tunneling of a leech into a free flap breast reconstruction. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 64(12):1687-8, 2011 Dec AS - J Plast Reconstr Aesthet Surg. 64(12):1687-8, 2011 Dec NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 64 IP - 12 PG - 1687-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Adult MH - Animals MH - *Carcinoma, Ductal, Breast/su [Surgery] MH - Dilatation, Pathologic MH - Female MH - Hirudo medicinalis MH - Humans MH - *Hyperemia/th [Therapy] MH - Leeching/ae [Adverse Effects] MH - *Leeching MH - Mammaplasty MH - Surgical Flaps/pa [Pathology] MH - *Surgical Flaps AB - Leeches are well known to migrate over the surface of the treated tissues. At times, they can be located in remote locations once they become engorged and detach. We report the first case of a leech tunneling through a dermal bite wound on a breast free flap. Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DO - https://dx.doi.org/10.1016/j.bjps.2011.05.014 PT - Case Reports PT - Journal Article ID - S1748-6815(11)00253-1 [pii] ID - 10.1016/j.bjps.2011.05.014 [doi] PP - ppublish PH - 2011/03/14 [received] PH - 2011/05/09 [revised] PH - 2011/05/14 [accepted] LG - English EP - 20110612 DP - 2011 Dec EZ - 2011/06/15 06:00 DA - 2012/01/20 06:00 DT - 2011/06/14 06:00 YR - 2011 ED - 20120119 RD - 20111114 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21664204 <389. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21388901 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - JoAnna Nguyen T AU - Carey JN AU - Wong AK FA - JoAnna Nguyen, T FA - Carey, Joseph N FA - Wong, Alex K IN - JoAnna Nguyen, T. Division of Plastic and Reconstructive Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St. Suite 415, Los Angeles, CA 90033, USA. TI - Use of human acellular dermal matrix in implant- based breast reconstruction: evaluating the evidence. [Review] SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 64(12):1553-61, 2011 Dec AS - J Plast Reconstr Aesthet Surg. 64(12):1553-61, 2011 Dec NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 64 IP - 12 PG - 1553-61 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - *Breast Implantation MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Implant Capsular Contracture/ep [Epidemiology] MH - Implant Capsular Contracture/pc [Prevention & Control] MH - Mastectomy MH - *Skin, Artificial MH - Tissue Expansion Devices MH - Treatment Outcome AB - The use of acellular dermal matrix (ADM) in implant based breast reconstruction has become increasingly popular to the point that a subset of surgeons use ADM for virtually every tissue expander/implant based reconstruction. While there may be a number of perceived and anecdotal advantages such as decreased post-operative pain, increased initial expander fill volume, and improved aesthetic outcome, it remains unclear as to whether there is sufficient evidence to support these as well as other claims or its routine use. In this review, we identified all papers in the PubMed and Medline databases that addressed outcomes of the use of ADM in single and multiple staged implant based breast reconstruction. Papers were evaluated for any claim of benefit in using ADM in breast reconstruction. The following perceived advantages were supported solely by anecdotal reports and opinions: reduction in post-op pain, decreased operative time, precise control of the lateral and IMF, maximal use of mastectomy skin flaps, and improved lower pole expansion. There was inconsistent data for commonly perceived advantages, such as: eliminating the need for expanders, increased initial fill volumes, fewer expansions, faster time to reconstruction completion, decreased rate of revision, and improved aesthetic outcome. We found consistent support for a decreased incidence of capsular contracture; however the existing reports have limited long term follow-up. Despite the many heralded benefits of ADM in breast reconstruction, the data supporting these claims is mostly anecdotal. Both long term outcomes and randomized controlled prospective studies are needed in order to definitively evaluate the perceived advantages of ADM in breast reconstruction. Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DO - https://dx.doi.org/10.1016/j.bjps.2011.02.001 PT - Journal Article PT - Review ID - S1748-6815(11)00043-X [pii] ID - 10.1016/j.bjps.2011.02.001 [doi] PP - ppublish PH - 2010/07/29 [received] PH - 2011/01/26 [revised] PH - 2011/02/02 [accepted] LG - English EP - 20110308 DP - 2011 Dec EZ - 2011/03/11 06:00 DA - 2012/01/20 06:00 DT - 2011/03/11 06:00 YR - 2011 ED - 20120119 RD - 20111114 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21388901 <390. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22094736 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Colwell AS AU - Damjanovic B AU - Zahedi B AU - Medford-Davis L AU - Hertl C AU - Austen WG Jr FA - Colwell, Amy S FA - Damjanovic, Branimir FA - Zahedi, Bita FA - Medford-Davis, Laura FA - Hertl, Catherine FA - Austen, William G Jr IN - Colwell, Amy S. Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. acolwell@partners.org TI - Retrospective review of 331 consecutive immediate single-stage implant reconstructions with acellular dermal matrix: indications, complications, trends, and costs. SO - Plastic & Reconstructive Surgery. 128(6):1170-8, 2011 Dec AS - Plast Reconstr Surg. 128(6):1170-8, 2011 Dec NJ - Plastic and reconstructive surgery VO - 128 IP - 6 PG - 1170-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Aged, 80 and over MH - Biocompatible Materials/ec [Economics] MH - *Biocompatible Materials MH - Breast Implants/ec [Economics] MH - Breast Implants/td [Trends] MH - *Breast Implants MH - *Collagen MH - Costs and Cost Analysis MH - Female MH - Humans MH - Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mammaplasty/td [Trends] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Complications/ec [Economics] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/su [Surgery] MH - Reoperation MH - Retrospective Studies MH - Risk Factors AB - BACKGROUND: Immediate single-stage direct-to-implant breast reconstruction with acellular dermal matrix optimizes aesthetics by preserving the mastectomy skin envelope. The authors report trends, early complications, and costs. AB - METHODS: A retrospective review of three surgeons' experience was performed for immediate single-stage implant reconstruction with acellular dermal matrix and tissue expander reconstruction without it at Massachusetts General Hospital. AB - RESULTS: Two hundred eleven patients had 331 direct-to-implant reconstructions using AlloDerm following nipple-sparing (n = 66) or skin-sparing (n = 265) mastectomy for cancer (n = 216) or prophylaxis (n = 115). The number of single-stage implant reconstructions increased from seven in 2006 to 116 in 2009. The percentage performed for prophylaxis increased from 29 percent to 41 percent. Fifty-one patients underwent preoperative (n = 33) or postoperative (n = 18) irradiation. Total complications included 10 infections (3.0 percent), five seromas (1.5 percent), four hematomas (1.2 percent), and 30 reconstructions (9.1 percent), with skin necrosis leading to five implant losses (1.5 percent). Tissue expander reconstruction without AlloDerm had a similar total complication rate (158 reconstructions) (p = 0.18), including nine infections (5.7 percent), three seromas (1.9 percent), three hematomas (1.9 percent), and 16 reconstructions (10.1 percent), with skin necrosis leading to 11 implant losses (7.0 percent). A higher complication rate occurred in the surgeons' combined first year performing single-stage implant reconstruction (21.4 percent) compared with subsequent years (10.9 percent) (p < 0.02) and in one- or two-stage reconstruction patients undergoing irradiation (p = 0.005). There was no significant difference in total overall costs (p = 0.8). AB - CONCLUSIONS: Immediate single-stage implant reconstruction using acellular dermal matrix offers a cost-effective reconstruction with a low complication rate. This may be the procedure of choice in select patients. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318230c2f6 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e318230c2f6 [doi] ID - 00006534-201112000-00005 [pii] PP - ppublish LG - English DP - 2011 Dec EZ - 2011/11/19 06:00 DA - 2012/01/04 06:00 DT - 2011/11/19 06:00 YR - 2011 ED - 20120103 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22094736 <391. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22094735 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H AU - Serletti JM FA - Sbitany, Hani FA - Serletti, Joseph M IN - Sbitany, Hani. University of Pennsylvania, Philadelphia, PA, USA. hani.sbitany@uphs.upenn.edu TI - Acellular dermis-assisted prosthetic breast reconstruction: a systematic and critical review of efficacy and associated morbidity. [Review] CM - Comment in: Plast Reconstr Surg. 2012 Sep;130(3):499e-500e; PMID: 22929292 CM - Comment in: Plast Reconstr Surg. 2012 Jul;130(1):190e-191e; author reply 191e-192e; PMID: 22743916 SO - Plastic & Reconstructive Surgery. 128(6):1162-9, 2011 Dec AS - Plast Reconstr Surg. 128(6):1162-9, 2011 Dec NJ - Plastic and reconstructive surgery VO - 128 IP - 6 PG - 1162-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Biocompatible Materials MH - *Breast Implants MH - Cohort Studies MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Postoperative Complications/et [Etiology] MH - Postoperative Complications/su [Surgery] MH - Prosthesis-Related Infections/et [Etiology] MH - Prosthesis-Related Infections/su [Surgery] MH - Reoperation MH - Seroma/et [Etiology] MH - Surgical Wound Infection/et [Etiology] MH - Surgical Wound Infection/su [Surgery] MH - Tissue Expansion Devices AB - BACKGROUND: The use of acellular dermal matrix to assist in two-stage expander/implant breast reconstruction has increased over recent years. However, there are questions regarding the potential for increased morbidity when using these techniques relative to standard submuscular coverage techniques. This systematic review combines published data comparing the techniques, to compare morbidity and advantages of acellular dermal matrix relative to standard submuscular coverage techniques. AB - METHODS: An English language literature search was performed to find articles reporting outcomes of two-stage expander/implant reconstruction using acellular dermal matrix. The outcome categories analyzed were patient/treatment demographics, tissue expander characteristics, and complications. AB - RESULTS: Nine articles met inclusion criteria for this analysis. Six of these were matched cohort studies comparing outcomes of acellular dermal matrix techniques to standard submuscular techniques. The remaining three were case series of acellular dermal matrix techniques. The only difference found in complications was a higher rate of seroma for the acellular dermal matrix group (4.3 percent versus 8.4 percent, p = 0.03). Despite this, both groups illustrated similar rates of infection leading to explantation (3.2 percent for submuscular and 3.4 percent for acellular dermal matrix, p = 0.18). In addition, acellular dermal matrix techniques illustrated greater intraoperative fill volumes and consistently fewer fills required to reach expander capacity. AB - CONCLUSIONS: The use of acellular dermal matrix in two-stage expander/implant reconstruction offers a safety profile similar to that of standard submuscular techniques. Both techniques have shown similar rates of infection ultimately requiring explantation. In addition, acellular dermal matrix offers the advantage of a more rapid reconstruction with less need for manipulation of the prosthetic through filling. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318230c29e PT - Comparative Study PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e318230c29e [doi] ID - 00006534-201112000-00004 [pii] PP - ppublish LG - English DP - 2011 Dec EZ - 2011/11/19 06:00 DA - 2012/01/04 06:00 DT - 2011/11/19 06:00 YR - 2011 ED - 20120103 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22094735 <392. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21359980 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Eisenberg T FA - Eisenberg, Ted TI - Implant exposure through a breast augmentation incision repaired with porcine acellular dermal matrix (StratticeTM): a technique to ensure graft take. SO - Aesthetic Plastic Surgery. 35(4):681-3, 2011 Aug AS - Aesthetic Plast Surg. 35(4):681-3, 2011 Aug NJ - Aesthetic plastic surgery VO - 35 IP - 4 PG - 681-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Biocompatible Materials MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implants/ae [Adverse Effects] MH - *Collagen MH - Humans MH - *Mammaplasty/ae [Adverse Effects] RN - 0 (Biocompatible Materials) RN - 0 (strattice) RN - 9007-34-5 (Collagen) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-011-9672-5 PT - Letter ID - 10.1007/s00266-011-9672-5 [doi] PP - ppublish LG - English DP - 2011 Aug EZ - 2011/03/02 06:00 DA - 2012/01/04 06:00 DT - 2011/03/02 06:00 YR - 2011 ED - 20120103 RD - 20110801 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21359980 <393. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22030500 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Vardanian AJ AU - Clayton JL AU - Roostaeian J AU - Shirvanian V AU - Da Lio A AU - Lipa JE AU - Crisera C AU - Festekjian JH FA - Vardanian, Andrew J FA - Clayton, John L FA - Roostaeian, Jason FA - Shirvanian, Vaheh FA - Da Lio, Andrew FA - Lipa, Joan E FA - Crisera, Christopher FA - Festekjian, Jaco H IN - Vardanian, Andrew J. Division of Plastic and Reconstructive Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA. TI - Comparison of implant-based immediate breast reconstruction with and without acellular dermal matrix. SO - Plastic & Reconstructive Surgery. 128(5):403e-410e, 2011 Nov AS - Plast Reconstr Surg. 128(5):403e-410e, 2011 Nov NJ - Plastic and reconstructive surgery VO - 128 IP - 5 PG - 403e-410e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - *Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - *Collagen MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - Logistic Models MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - Multivariate Analysis MH - Odds Ratio MH - Postoperative Care/mt [Methods] MH - Postoperative Complications/pp [Physiopathology] MH - Retrospective Studies MH - Risk Assessment MH - *Surgical Flaps MH - Time Factors MH - Tissue Expansion/mt [Methods] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - BACKGROUND: Acellular dermal matrix is frequently used in implant-based breast reconstruction to cover the inferior aspect of the breast pocket. Its performance profile remains equivocal. The authors studied whether adding it in implant-based immediate breast reconstruction improved outcomes when compared with non-acellular dermal matrix reconstruction. AB - METHODS: Patients undergoing implant-based immediate breast reconstruction at a single academic medical center were evaluated. Aesthetic outcomes and postoperative complications were assessed and direct comparisons were made between acellular dermal matrix and non-acellular dermal matrix cohorts. AB - RESULTS: A total of 203 patients underwent 337 immediate expander-based breast reconstructions [with acellular dermal matrix, n=208 (61.7 percent); without, n=129 (38.3 percent)]. Patient characteristics, including age at time of reconstruction (mean, 49+/-11 versus 47+/-10 years) and body mass index (mean, 23+/-5 versus 23+/-3 kg/m) were similar between groups (p>0.05). Complications occurred in one-third of patients (33.5 percent). In univariate analyses, acellular dermal matrix use had fewer overall complications (odds ratio, 0.61; 95 percent CI, 0.38 to 0.97). The incidences of seroma/hematoma (p=0.59), infection (p=0.31), and wound complications (p=0.26) did not differ. Aesthetic outcomes were higher in the acellular dermal matrix group. In multivariate logistic regression, acellular dermal matrix use was associated with less capsular contracture (odds ratio, 0.18; 95 percent CI, 0.08 to 0.43) and mechanical shift (odds ratio, 0.23; 95 percent CI, 0.06 to 0.78). AB - CONCLUSIONS: Optimizing the inframammary fold with acellular dermal matrix creates a superior aesthetic result. Its use appears safe and is associated with less capsular contracture and mechanical shift and improvement in the inframammary fold appearance, without increasing postoperative complications. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31822b6637 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e31822b6637 [doi] ID - 00006534-201111000-00006 [pii] PP - ppublish LG - English DP - 2011 Nov EZ - 2011/10/28 06:00 DA - 2011/12/17 06:00 DT - 2011/10/28 06:00 YR - 2011 ED - 20111216 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22030500 <394. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22030489 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nyame TT AU - Lemon KP AU - Kolter R AU - Liao EC FA - Nyame, Theodore T FA - Lemon, Katherine P FA - Kolter, Roberto FA - Liao, Eric C IN - Nyame, Theodore T. Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. TI - High-throughput assay for bacterial adhesion on acellular dermal matrices and synthetic surgical materials. SO - Plastic & Reconstructive Surgery. 128(5):1061-8, 2011 Nov AS - Plast Reconstr Surg. 128(5):1061-8, 2011 Nov NJ - Plastic and reconstructive surgery VO - 128 IP - 5 PG - 1061-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766523 OI - Source: NLM. NIHMS509333 SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Bacterial Adhesion/ph [Physiology] MH - Biocompatible Materials MH - *Collagen MH - Culture Media MH - Humans MH - *Materials Testing/mt [Methods] MH - Prostheses and Implants MH - Skin, Artificial MH - *Staphylococcus aureus/gd [Growth & Development] MH - Staphylococcus aureus/ph [Physiology] MH - *Surgical Mesh MH - Tissue Engineering AB - BACKGROUND: There has been increasing use of synthetic and acellular dermal matrix materials in surgery, ranging from breast reconstruction to hernia repairs. There is a paucity of data on how acellular dermal matrix compares with other surgical materials as a substrate for bacterial adhesion, the first step in formation biofilm, which occurs in prosthetic wound infections. The authors have designed a high-throughput assay to evaluate Staphylococcus aureus adherence on various synthetic and biologically derived materials. AB - METHODS: Clinical isolates of S. aureus (strains SC-1 and UAMS-1) were cultured with different materials, and bacterial adherence was measured using a resazurin cell vitality assay. Four materials that are commonly used in surgery were evaluated: Prolene mesh, Vicryl mesh, and two different acellular dermal matrix preparations (AlloDerm and FlexHD). The authors were able to develop a high-throughput and reliable assay for quantifying bacterial adhesion on synthetic and biologically derived materials. AB - RESULTS: The resazurin vitality assay can be reliably used to quantify bacterial adherence to acellular dermal matrix material and synthetic material. S. aureus strains SC-1 and UAMS-1 both adhered better to acellular dermal matrix materials (AlloDerm versus FlexHD) than to the synthetic material Prolene. S. aureus also adhered better to Vicryl than to Prolene. Strain UAMS-1 adhered better to Vicryl and acellular dermal matrix materials than did strain SC-1. AB - CONCLUSIONS: The results show that S. aureus adheres more readily to acellular dermal matrix material than to synthetic material. The resazurin assay provides a standard method for evaluating surgical materials with regard to bacterial adherence and potential propensity for biofilm development. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 0 (Culture Media) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31822b65af PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e31822b65af [doi] ID - 00006534-201111000-00015 [pii] ID - PMC3766523 [pmc] ID - NIHMS509333 [mid] PP - ppublish GI - No: K08 AI070561 Organization: (AI) *NIAID NIH HHS* Country: United States GI - No: R01 GM058213 Organization: (GM) *NIGMS NIH HHS* Country: United States GI - No: GM58213 Organization: (GM) *NIGMS NIH HHS* Country: United States LG - English DP - 2011 Nov EZ - 2011/10/28 06:00 DA - 2011/12/17 06:00 DT - 2011/10/28 06:00 YR - 2011 ED - 20111216 RD - 20161019 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=22030489 <395. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21813885 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Department of Plastic Surgery, Loma Linda University Medical Center, California, USA. TI - Revisionary breast surgery with acellular dermal matrices. SO - Aesthetic Surgery Journal. 31(6):700-10, 2011 Aug AS - Aesthet. surg. j.. 31(6):700-10, 2011 Aug NJ - Aesthetic surgery journal VO - 31 IP - 6 PG - 700-10 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Female MH - Humans MH - *Implant Capsular Contracture/th [Therapy] AB - Revisionary breast surgeries are challenging, and advanced techniques must often be utilized in the correction of the underlying anatomical deformities. In this Featured Operative Technique, the authors describe their method, which includes a combination of revisionary surgery techniques with site change and acellular dermal matrices. This use of acellular dermal matrices has four indications based on the underlying clinical presentation: (1) as a lower pole implant interface (usually for revision mastopexy), (2) as a capsular contracture treatment (technically similar to lower pole interface), (3) as a tissue thickener (superomedial or inferolateral implant interface), or (4) as an implant stabilizer (malposition correction). ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X11415395 PT - Journal Article ID - 31/6/700 [pii] ID - 10.1177/1090820X11415395 [doi] PP - ppublish LG - English DP - 2011 Aug EZ - 2011/08/05 06:00 DA - 2011/12/13 00:00 DT - 2011/08/05 06:00 YR - 2011 ED - 20111123 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21813885 <396. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 22084645 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Hoppe IC AU - Yueh JH AU - Wei CH AU - Ahuja NK AU - Patel PP AU - Datiashvili RO FA - Hoppe, Ian C FA - Yueh, Janet H FA - Wei, Cindy H FA - Ahuja, Naveen K FA - Patel, Priti P FA - Datiashvili, Ramazi O IN - Hoppe, Ian C. Department of Surgery, Division of Plastic Surgery, New Jersey Medical School-University of Medicine and Dentistry of New Jersey. TI - Complications following expander/implant breast reconstruction utilizing acellular dermal matrix: a systematic review and meta-analysis. SO - Eplasty [Electronic Resource]. 11:e40, 2011 AS - Eplasty. 11:e40, 2011 NJ - Eplasty VO - 11 PG - e40 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208410 CP - United States AB - BACKGROUND: The recent increase in popularity of acellular dermal matrix assistance in immediate expander/implant breast reconstruction has led to variety of viewpoints. Many studies are published indicating an increase in complications with the use of acellular dermal matrix, while others indicate there is no increase in complications. AB - METHODS: This meta-analysis utilizes information from available studies that directly compare one specific type of acellular dermal matrix with traditional methods of immediate expander/implant breast reconstruction. Eight studies were found through a meticulous literature search that met these criteria. AB - RESULTS: There was more than a 2-fold increase in the number of infections and explanations in the acellular dermal matrix group compared to the control. There was a 3-fold increase in seroma formation in the acellular dermal matrix group compared to the control. There was a significant difference of intraoperative fill volumes between the acellular dermal matrix group compared to the control. AB - CONCLUSIONS: This study illustrates that after pooling all available date regarding the use of acellular dermal matrix in immediate expander/implant breast reconstruction there appears to be an increased rate of complications. However, the increased intraoperative fill volume may lead to ultimately greater patient satisfaction. ES - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC3208410 [pmc] PP - ppublish LG - English EP - 20111103 DP - 2011 EZ - 2011/11/16 06:00 DA - 2011/11/16 06:01 DT - 2011/11/16 06:00 YR - 2011 ED - 20111123 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=22084645 <397. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21679622 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Huston TL AU - Taback B AU - Rohde CH FA - Huston, Tara L FA - Taback, Bret FA - Rohde, Christine H IN - Huston, Tara L. Columbia University Medical Center, New York-Presbyterian Hospital, New York, New York, USA. tarahustonmd@gmail.com TI - Chest wall reconstruction with porcine acellular dermal matrix (strattice) and a latissimus myocutaneous flap. SO - American Surgeon. 77(6):e115-6, 2011 Jun AS - Am Surg. 77(6):e115-6, 2011 Jun NJ - The American surgeon VO - 77 IP - 6 PG - e115-6 PI - Journal available in: Print PI - Citation processed from: Internet JC - 43e, 0370522 IO - Am Surg SB - Index Medicus CP - United States MH - *Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - Mastectomy, Radical MH - Middle Aged MH - *Reconstructive Surgical Procedures/mt [Methods] MH - *Ribs/pa [Pathology] MH - *Ribs/su [Surgery] MH - *Skin, Artificial MH - *Thoracic Wall/su [Surgery] ES - 1555-9823 IL - 0003-1348 PT - Case Reports PT - Journal Article PP - ppublish LG - English DP - 2011 Jun EZ - 2011/06/18 06:00 DA - 2011/09/02 06:00 DT - 2011/06/18 06:00 YR - 2011 ED - 20110901 RD - 20110617 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21679622 <398. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21701324 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chang DW FA - Chang, David W IN - Chang, David W. Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. dchang@mdanderson.org TI - Discussion: The scarless latissimus dorsi flap for full muscle coverage in device-based immediate breast reconstruction: an autologous alternative to acellular dermal matrix. CM - Comment on: Plast Reconstr Surg. 2011 Jul;128(1):71-9; PMID: 21701323 SO - Plastic & Reconstructive Surgery. 128(1):80-3, 2011 Jul AS - Plast Reconstr Surg. 128(1):80-3, 2011 Jul NJ - Plastic and reconstructive surgery VO - 128 IP - 1 PG - 80-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Body Mass Index MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Muscle, Skeletal/tr [Transplantation] MH - Skin Transplantation/mt [Methods] MH - *Surgical Flaps MH - Time Factors ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318218fcf6 PT - Comment PT - Journal Article ID - 10.1097/PRS.0b013e318218fcf6 [doi] ID - 00006534-201107000-00014 [pii] PP - ppublish LG - English DP - 2011 Jul EZ - 2011/06/28 06:00 DA - 2011/08/31 06:00 DT - 2011/06/25 06:00 YR - 2011 ED - 20110830 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21701324 <399. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21701323 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Elliott LF AU - Ghazi BH AU - Otterburn DM FA - Elliott, L Franklyn FA - Ghazi, Bahair H FA - Otterburn, David M IN - Elliott, L Franklyn. Department of Plastic and Reconstructive Surgery, Emory University, Atlanta, Ga, USA. felliott@atlplastic.com TI - The scarless latissimus dorsi flap for full muscle coverage in device-based immediate breast reconstruction: an autologous alternative to acellular dermal matrix. CM - Comment in: Plast Reconstr Surg. 2012 Mar;129(3):552e-554e; author reply 554e; PMID: 22374008 CM - Comment in: Plast Reconstr Surg. 2011 Jul;128(1):80-3; PMID: 21701324 CM - Comment in: Plast Reconstr Surg. 2012 Jan;129(1):167e-168e; PMID: 22186538 SO - Plastic & Reconstructive Surgery. 128(1):71-9, 2011 Jul AS - Plast Reconstr Surg. 128(1):71-9, 2011 Jul NJ - Plastic and reconstructive surgery VO - 128 IP - 1 PG - 71-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Body Mass Index MH - *Breast Implants MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Muscle, Skeletal/tr [Transplantation] MH - Retrospective Studies MH - Skin Transplantation/mt [Methods] MH - *Surgical Flaps MH - Time Factors AB - BACKGROUND: Thin patients have fewer autologous options in postmastectomy reconstruction and are frequently limited to device-based techniques. The latissimus dorsi flap remains a viable option with which to provide autologous coverage, although for certain patients the donor scar can be a point of contention. The scarless latissimus dorsi flap is a way of mitigating these concerns. The authors present their 6-year single-surgeon experience with scarless latissimus dorsi flap reconstruction. AB - METHODS: A retrospective review of scarless latissimus dorsi flap reconstruction was performed. Charts from 2003 to 2009 were queried for demographic characteristics, nonoperative therapies, and short- and long-term complications. Results were compared with historical data. AB - RESULTS: Thirty-one patients with 52 flaps were identified. Fifty-one flaps were immediate reconstructions, with an average age of 47 years and body mass index of 22.8 kg/m. Thirteen patients were treated with chemotherapy and four were irradiated, two preoperatively. The single drain was removed on average at 21 days. Complications included three hematomas (5.8 percent), two capsular contractures (3.8 percent), and two infections (3.8 percent). Average time to secondary reconstruction was 143 days. There were five unplanned revisions (9.6 percent). There were no flap failures or tissue expander losses. AB - CONCLUSIONS: The scarless latissimus dorsi flap is an effective method for providing durable homogenous device coverage in the thinner patient (body mass index <24). With the advent of acellular dermal matrices, device coverage has been made simpler, but this comes at a cost. Coverage is thin, the matrix is not initially vascularized, and products are expensive. For these reasons, use of the scarless latissimus dorsi flap is an excellent alternative, particularly in the patient with a low body mass index. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.(Figure is included in full-text article.). ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318218fcc6 PT - Journal Article ID - 10.1097/PRS.0b013e318218fcc6 [doi] ID - 00006534-201107000-00013 [pii] PP - ppublish LG - English DP - 2011 Jul EZ - 2011/06/28 06:00 DA - 2011/08/31 06:00 DT - 2011/06/25 06:00 YR - 2011 ED - 20110830 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21701323 <400. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21701307 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tom L AU - Broer N AU - Hoang D AU - Narayan D FA - Tom, Laura FA - Broer, Niclas FA - Hoang, Don FA - Narayan, Deepak TI - Novel use of acellularized dermis for breast reconstruction. SO - Plastic & Reconstructive Surgery. 128(1):31e-3e, 2011 Jul AS - Plast Reconstr Surg. 128(1):31e-3e, 2011 Jul NJ - Plastic and reconstructive surgery VO - 128 IP - 1 PG - 31e-3e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Skin Transplantation/mt [Methods] MH - *Skin Transplantation ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182174501 PT - Case Reports PT - Editorial ID - 10.1097/PRS.0b013e3182174501 [doi] ID - 00006534-201107000-00085 [pii] PP - ppublish LG - English DP - 2011 Jul EZ - 2011/06/28 06:00 DA - 2011/08/31 06:00 DT - 2011/06/25 06:00 YR - 2011 ED - 20110830 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21701307 <401. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21508823 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Serra-Renom JM AU - Munoz-Olmo J AU - Serra-Mestre JM FA - Serra-Renom, Jose M FA - Munoz-Olmo, Juan FA - Serra-Mestre, Jose M IN - Serra-Renom, Jose M. From the Aesthetic Plastic Surgery Department, Hospital Quiron Barcelona, Universidad Internacional de Cataluna, Barcelona, Spain. serrarenom@gmail.com TI - Breast reconstruction with fat grafting alone. SO - Annals of Plastic Surgery. 66(6):598-601, 2011 Jun AS - Ann Plast Surg. 66(6):598-601, 2011 Jun NJ - Annals of plastic surgery VO - 66 IP - 6 PG - 598-601 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Adipose Tissue/tr [Transplantation] MH - Aged MH - Humans MH - Injections MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged AB - We describe our technique for breast reconstruction using fat grafting alone in patients with flaccid, elastic skin, via multiple injections of fat tissue. The technique involves following 3 stages: puckering stitches, to remodel the mass each time fat grafting is performed; cone formation-pexia, the creation and lifting of a cone with the tissue from the area; and neoformation of the inframammary fold, in which the cone is anchored in the pectoralis major and the fold at the level of the sixth rib. Using fat grafting and these 3 maneuvers, we obtain satisfactory breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3181f3e33e PT - Case Reports PT - Journal Article ID - 10.1097/SAP.0b013e3181f3e33e [doi] PP - ppublish LG - English DP - 2011 Jun EZ - 2011/04/22 06:00 DA - 2011/08/30 06:00 DT - 2011/04/22 06:00 YR - 2011 ED - 20110829 RD - 20110511 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21508823 <402. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21233698 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Rawlani V AU - Buck DW 2nd AU - Johnson SA AU - Heyer KS AU - Kim JY FA - Rawlani, Vinay FA - Buck, Donald W 2nd FA - Johnson, Sarah A FA - Heyer, Kamaldeep S FA - Kim, John Y S IN - Rawlani, Vinay. Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. TI - Tissue expander breast reconstruction using prehydrated human acellular dermis. SO - Annals of Plastic Surgery. 66(6):593-7, 2011 Jun AS - Ann Plast Surg. 66(6):593-7, 2011 Jun NJ - Annals of plastic surgery VO - 66 IP - 6 PG - 593-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Aged, 80 and over MH - *Biocompatible Materials/ad [Administration & Dosage] MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Tissue Expansion Devices AB - INTRODUCTION: Human acellular dermal matrices help facilitate immediate tissue expander-implant breast reconstruction by providing support to the inferolateral pole, improving control of implant position, and enhancing early volume expansion. Although several freeze-dried human acellular dermal products have demonstrated reasonable safety and efficacy in immediate tissue expander-implant breast reconstruction, no dedicated studies have evaluated clinical outcomes of prehydrated human acellular dermal matrix (PHADM) in breast reconstruction. AB - METHODS: The outcomes of 121 consecutive tissue expander reconstructions performed by the senior author using PHADM were evaluated. AB - RESULTS: Mean intraoperative tissue expander fill volume was 256.6 +/- 133 mL, 60% of final expander volume. Patients required an average of 3.2 additional expansions prior to tissue expander-to-implant exchange. Mean follow-up period after reconstruction was 44 +/- 26.5 weeks. Complications occurred in 20 (16.5%) breasts, including 9 (7.4%) soft-tissue infections, 8 (6.6%) partial mastectomy flap necroses, and 2 (1.7%) seromas. Eleven (9.1%) breasts ultimately required explantation. Patients receiving radiation demonstrated a strong trend toward greater complications (30.8% vs. 13.7%, P = 0.0749). AB - CONCLUSIONS: The outcomes and complication rates of PHADM tissue expander breast reconstruction are comparable to those reported with freeze-dried human acellular dermis. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3181f3ed0a PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/SAP.0b013e3181f3ed0a [doi] PP - ppublish LG - English DP - 2011 Jun EZ - 2011/01/15 06:00 DA - 2011/08/30 06:00 DT - 2011/01/15 06:00 YR - 2011 ED - 20110829 RD - 20110511 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21233698 <403. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21407050 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Phillips BT AU - Wang ED AU - Mirrer J AU - Lanier ST AU - Khan SU AU - Dagum AB AU - Bui DT FA - Phillips, Brett T FA - Wang, Eric D FA - Mirrer, Joshua FA - Lanier, Steven T FA - Khan, Sami U FA - Dagum, Alexander B FA - Bui, Duc T IN - Phillips, Brett T. Division of Plastic and Reconstructive Surgery, Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY, USA. brett.phillips@stonybrook.edu TI - Current practice among plastic surgeons of antibiotic prophylaxis and closed-suction drains in breast reconstruction: experience, evidence, and implications for postoperative care. SO - Annals of Plastic Surgery. 66(5):460-5, 2011 May AS - Ann Plast Surg. 66(5):460-5, 2011 May NJ - Annals of plastic surgery VO - 66 IP - 5 PG - 460-5 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Antibiotic Prophylaxis/st [Standards] MH - Antibiotic Prophylaxis/td [Trends] MH - Attitude of Health Personnel MH - Canada MH - Chi-Square Distribution MH - Esthetics MH - Evidence-Based Medicine MH - Female MH - Follow-Up Studies MH - Health Care Surveys MH - Humans MH - Male MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - *Postoperative Care/mt [Methods] MH - Practice Patterns, Physicians' MH - Risk Assessment MH - Societies, Medical MH - Suction/is [Instrumentation] MH - *Suction/mt [Methods] MH - *Surgery, Plastic/st [Standards] MH - Surgery, Plastic/td [Trends] MH - Surgical Wound Infection/pc [Prevention & Control] MH - Surveys and Questionnaires MH - Treatment Outcome MH - United States AB - BACKGROUND: Despite their widespread use, there are no evidence-based guidelines on the management of closed-suction drains or antibiotics in postmastectomy breast reconstruction. The purpose of this study was to assess consensus and variation in postoperative care among plastic surgeons. AB - METHODS: The authors designed and administered a self-reported, anonymous survey to 4669 American Society of Plastic Surgeons and Canadian Society of Plastic Surgeons members in October 2009. AB - RESULTS: A total of 650 completed surveys were available for analysis. A majority (>81%) of respondents reported using closed-suction drains in breast reconstruction. Most surgeons (>93%) used a volume criteria for drain removal, most commonly when drain output was <=30 mL over 24 hours (>86%). Preoperative antibiotic use was nearly universal (98%), usually consisting of intravenous cefazolin (97%). Postoperative care demonstrated less uniformity with outpatient antibiotics administered by 72% of respondents. Surgeons were divided on when to discontinue outpatient antibiotics: 46% preferred concomitant discontinuation with drains, whereas 52% preferred a specific postoperative day. No clear consensus was observed for the number (1 or 2) or type (Jackson-Pratt or Blake) of drains used. Respondents were further divided on the restriction of postoperative showering with drains and the use of acellular dermal matrix. AB - CONCLUSIONS: These results demonstrate a consensus for drain use, drain removal, and preoperative antibiotic administration. There was no consensus for number or type of drain used, postoperative antibiotic use, shower restrictions, and use of acellular dermal matrix. Our results further emphasize the need for evidence-based postoperative-care guidelines specific to breast reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31820c0593 PT - Comparative Study PT - Journal Article ID - 10.1097/SAP.0b013e31820c0593 [doi] PP - ppublish LG - English DP - 2011 May EZ - 2011/03/17 06:00 DA - 2011/08/20 06:00 DT - 2011/03/17 06:00 YR - 2011 ED - 20110819 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21407050 <404. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20091328 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - O'Brien JA AU - Ignotz R AU - Montilla R AU - Broderick GB AU - Christakis A AU - Dunn RM FA - O'Brien, J A FA - Ignotz, R FA - Montilla, R FA - Broderick, G B FA - Christakis, A FA - Dunn, R M IN - O'Brien, J A. Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Julie.O'Brien@umassmemorial.org TI - Long-term histologic and mechanical results of a PermacolTM abdominal wall explant. SO - Hernia. 15(2):211-5, 2011 Apr AS - Hernia. 15(2):211-5, 2011 Apr NJ - Hernia : the journal of hernias and abdominal wall surgery VO - 15 IP - 2 PG - 211-5 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d01, 9715168 IO - Hernia SB - Index Medicus CP - France MH - *Abdominal Wall/pa [Pathology] MH - *Abdominal Wall/su [Surgery] MH - Biocompatible Materials/ch [Chemistry] MH - *Biocompatible Materials MH - Collagen/ch [Chemistry] MH - *Collagen/ph [Physiology] MH - Collagen Type I/an [Analysis] MH - Collagen Type III/an [Analysis] MH - Elastin/an [Analysis] MH - Female MH - Fibroblasts/ph [Physiology] MH - *Hematoma/su [Surgery] MH - Humans MH - Immunohistochemistry MH - Materials Testing MH - Middle Aged MH - Tensile Strength AB - PURPOSE: We hypothesize that PermacolTM may allow controlled integration over time while providing long-term mechanical stability and native tissue remodeling. The purpose of this report is to investigate these properties in an explanted piece of PermacolTM after 2 years in vivo. AB - METHODS: A 62-year-old female presented with a complex abdominal wall history having undergone a transverse rectus abdominis musculocutaneous (TRAM) flap breast reconstruction 10 years ago, followed by an abdominal wall repair with MarlexTM mesh for weakness 3 years later. Two years ago, she developed an abdominal bulge repaired with a PermacolTM overlay. Twenty-three months postoperatively, she presented with abdominal distension. Computed tomography (CT) scanning demonstrated a fluid collection behind the PermacolTM. She underwent incision and drainage of the hematoma/bursa and quilting repair of the abdominal wall. A 1 x 6-cm PermacolTM section was resected as part of closure. Histology, immunohistochemistry, and mechanical testing of the PermacolTM explant were performed. AB - RESULTS: Histology showed fibroblast and blood vessel ingrowth with no cellular infiltrates reflective of inflammation. Immunohistochemistry for human-specific collagen types I and III and elastin detected staining throughout. Sections stained with non-specific control antibody exhibited no discernable staining. Elastin highlighted blood vessels. Native PermacolTM had a breaking strength of ~20 N, while for explanted PermacolTM, it was ~33 N. AB - CONCLUSIONS: PermacolTM maintained durability while allowing vascular ingrowth without residual inflammation. Explant demonstrated integration with human collagen and elastin remodeling throughout. Increase in mechanical strength may reflect newly synthesized collagen and elastin. These histologic findings and clinical result support the use of PermacolTM in complex abdominal wall reconstruction. RN - 0 (Biocompatible Materials) RN - 0 (Collagen Type I) RN - 0 (Collagen Type III) RN - 0 (Permacol) RN - 9007-34-5 (Collagen) RN - 9007-58-3 (Elastin) ES - 1248-9204 IL - 1248-9204 DO - https://dx.doi.org/10.1007/s10029-010-0628-5 PT - Case Reports PT - Journal Article ID - 10.1007/s10029-010-0628-5 [doi] PP - ppublish PH - 2009/10/15 [received] PH - 2010/01/08 [accepted] LG - English EP - 20100121 DP - 2011 Apr EZ - 2010/01/22 06:00 DA - 2011/08/20 06:00 DT - 2010/01/22 06:00 YR - 2011 ED - 20110819 RD - 20171013 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=20091328 <405. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21617459 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jansen LA AU - Macadam SA FA - Jansen, Leigh A FA - Macadam, Sheina A IN - Jansen, Leigh A. Department of Surgery, Division of Plastic and Reconstructive Surgery, University of British Columbia, Vancouver, British Columbia, Canada. jansen.leigh@gmail.com TI - The use of AlloDerm in postmastectomy alloplastic breast reconstruction: part II. A cost analysis. [Review] SO - Plastic & Reconstructive Surgery. 127(6):2245-54, 2011 Jun AS - Plast Reconstr Surg. 127(6):2245-54, 2011 Jun NJ - Plastic and reconstructive surgery VO - 127 IP - 6 PG - 2245-54 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Biocompatible Materials/ae [Adverse Effects] MH - Biocompatible Materials/ec [Economics] MH - Breast Implants/ae [Adverse Effects] MH - *Breast Implants/ec [Economics] MH - Breast Neoplasms/su [Surgery] MH - Canada MH - Collagen/ae [Adverse Effects] MH - *Collagen/ec [Economics] MH - Cost-Benefit Analysis MH - Costs and Cost Analysis MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/ec [Economics] MH - Mammaplasty/mt [Methods] MH - *Mastectomy AB - BACKGROUND: Increasingly, AlloDerm is being used in alloplastic breast reconstruction, and has been the subject of a recent systematic review. The authors' objective was to perform a cost analysis comparing direct-to-implant with AlloDerm reconstruction to two-stage non-AlloDerm reconstruction. AB - METHODS: Seven clinically important health outcomes and their probabilities for both types of reconstruction were derived from the recent review. A decision analytic model from the Canadian provincial payer's perspective was constructed based on these health states. Direct medical costs were estimated from a university-based hospital, yielding expected costs for direct-to-implant reconstruction with AlloDerm and two-stage non-AlloDerm reconstruction. Sensitivity analyses were conducted. AB - RESULTS: Baseline and expected costs were calculated for direct-to-implant AlloDerm and two-stage non-AlloDerm reconstruction. Direct-to-implant reconstruction with AlloDerm was found to be less expensive in the baseline ($10,240 versus $10,584) and expected cost ($10,734 versus $11,251) using a 6 x 16-cm AlloDerm sheet. With a 6 x 12-cm sheet, expected cost falls to $9673. By increasing direct-to-implant operative time from 2 hours to 2.5 hours, expected cost rises to $11,784. If capsular contracture rate requiring revision is set at 15 percent for both procedures, expected costs are $10,926 and $11,251 for direct-to-implant and two-stage procedures, respectively. If the capsular contracture rate is lowered for either procedure, this has minimal impact on expected cost. AB - CONCLUSIONS: Although AlloDerm is expensive, it appears to be cost-effective if used for direct-to-implant breast reconstruction. The methods used here may be extrapolated to different centers incorporating local costs and complication rates. A formal randomized controlled trial, including costs, is recommended. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182131c6b PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e3182131c6b [doi] ID - 00006534-201106000-00013 [pii] PP - ppublish LG - English DP - 2011 Jun EZ - 2011/05/28 06:00 DA - 2011/08/11 06:00 DT - 2011/05/28 06:00 YR - 2011 ED - 20110810 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21617459 <406. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21617458 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Jansen LA AU - Macadam SA FA - Jansen, Leigh A FA - Macadam, Sheina A IN - Jansen, Leigh A. Department of Surgery, Division of Plastic and Reconstructive Surgery, University of British Columbia, Vancouver, British Columbia, Canada. jansen.leigh@gmail.com TI - The use of AlloDerm in postmastectomy alloplastic breast reconstruction: part I. A systematic review. [Review] SO - Plastic & Reconstructive Surgery. 127(6):2232-44, 2011 Jun AS - Plast Reconstr Surg. 127(6):2232-44, 2011 Jun NJ - Plastic and reconstructive surgery VO - 127 IP - 6 PG - 2232-44 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Biocompatible Materials MH - Breast Implants/ae [Adverse Effects] MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - Collagen/ae [Adverse Effects] MH - *Collagen MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - *Mammaplasty MH - *Mastectomy MH - Tissue Expansion AB - BACKGROUND: Postmastectomy alloplastic breast reconstruction is a common procedure that continues to evolve. Increasingly, AlloDerm is being used in both direct-to-implant and two-stage breast reconstruction. The objective of this systematic review was to summarize the outcomes from studies describing this use of AlloDerm, and to compare outcomes to those from studies reviewing non-AlloDerm alloplastic reconstruction. AB - METHODS: A computerized search was performed across multiple databases. Studies involving patients undergoing alloplastic breast reconstruction with AlloDerm were included. A systematic review was performed to include randomized controlled trials, comparative observational studies, noncomparative observational studies, and case series. AB - RESULTS: A systematic review of the literature revealed 14 studies that satisfied inclusion criteria. Both acute and long-term complication rates were obtained. No objective validated outcomes were reported. Ninety-three percent of included studies were level IV evidence. Complication rates were as follows: infection, 0 to 11 percent; hematoma, 0 to 6.7 percent; seroma, 0 to 9 percent; partial flap necrosis, 0 to 25 percent; implant exposure with removal, 0 to 14 percent; implant exposure with salvage, 0 to 4 percent; capsular contracture, 0 to 8 percent; and rippling, 0 to 6 percent. No study included a cost analysis. AB - CONCLUSIONS: Complications using AlloDerm are comparable to those of non-AlloDerm alloplastic reconstructions. AlloDerm appears to confer a low rate of capsular contracture. A formal analysis is required to determine AlloDerm's cost effectiveness in use for direct-to-implant reconstructions. In addition, a randomized controlled trial comparing AlloDerm use to conventional two-stage reconstruction is currently absent from the literature. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182131c56 PT - Journal Article PT - Review ID - 10.1097/PRS.0b013e3182131c56 [doi] ID - 00006534-201106000-00012 [pii] PP - ppublish LG - English DP - 2011 Jun EZ - 2011/05/28 06:00 DA - 2011/08/11 06:00 DT - 2011/05/28 06:00 YR - 2011 ED - 20110810 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21617458 <407. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21617431 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Craft RO AU - May JW Jr FA - Craft, Randall O FA - May, James W Jr TI - Staged nipple reconstruction with vascularized SurgiMend acellular dermal matrix. SO - Plastic & Reconstructive Surgery. 127(6):148e-9e, 2011 Jun AS - Plast Reconstr Surg. 127(6):148e-9e, 2011 Jun NJ - Plastic and reconstructive surgery VO - 127 IP - 6 PG - 148e-9e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty MH - *Nipples/su [Surgery] MH - *Skin, Artificial RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3182131e74 PT - Journal Article ID - 10.1097/PRS.0b013e3182131e74 [doi] ID - 00006534-201106000-00073 [pii] PP - ppublish LG - English DP - 2011 Jun EZ - 2011/05/28 06:00 DA - 2011/08/11 06:00 DT - 2011/05/28 06:00 YR - 2011 ED - 20110810 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21617431 <408. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21418652 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Crenshaw SA AU - Roller MD AU - Chapman JK FA - Crenshaw, Shirley A FA - Roller, Michael D FA - Chapman, Jeffery K IN - Crenshaw, Shirley A. Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA. screnshs@rams.colostate.edu TI - Immediate breast reconstruction with a saline implant and AlloDerm, following removal of a Phyllodes tumor. SO - World Journal of Surgical Oncology. 9:34, 2011 Mar 21 AS - World J Surg Oncol. 9:34, 2011 Mar 21 NJ - World journal of surgical oncology VO - 9 PG - 34 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101170544 IO - World J Surg Oncol PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070675 SB - Index Medicus CP - England MH - Adult MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Phyllodes Tumor/pa [Pathology] MH - *Phyllodes Tumor/su [Surgery] MH - Sodium Chloride AB - BACKGROUND: Phyllodes tumors are uncommon tumors of the breast that exhibit aggressive growth. While surgical management of the tumor has been reported, a single surgical approach with immediate breast reconstruction using AlloDerm has not been reported. AB - CASE PRESENTATION: A 22-year-old woman presented with a 4 cm mass in the left breast upon initial examination. Although the initial needle biopsy report indicated a fibroadenoma, the final pathologic report revealed a 6.5 cm x 6.4 cm x 6.4 cm benign phyllodes tumor ex vivo. Treatment was a simple nipple-sparing mastectomy coupled with immediate breast reconstruction. After the mastectomy, a subpectoral pocket was created for a saline implant and AlloDerm was stitched to the pectoralis and serratus muscle in the lower-pole of the breast. AB - CONCLUSIONS: Saline implant with AlloDerm can be used for immediate breast reconstruction post-mastectomy for treatment of a phyllodes tumor. RN - 0 (Alloderm) RN - 451W47IQ8X (Sodium Chloride) RN - 9007-34-5 (Collagen) ES - 1477-7819 IL - 1477-7819 DO - https://dx.doi.org/10.1186/1477-7819-9-34 PT - Case Reports PT - Journal Article ID - 1477-7819-9-34 [pii] ID - 10.1186/1477-7819-9-34 [doi] ID - PMC3070675 [pmc] PP - epublish PH - 2010/10/04 [received] PH - 2011/03/21 [accepted] LG - English EP - 20110321 DP - 2011 Mar 21 EZ - 2011/03/23 06:00 DA - 2011/08/05 06:00 DT - 2011/03/23 06:00 YR - 2011 ED - 20110804 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21418652 <409. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19597865 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Isken T AU - Onyedi M AU - Izmirli H AU - Alagoz S AU - Katz R FA - Isken, Tonguc FA - Onyedi, Murat FA - Izmirli, Hakki FA - Alagoz, Sahin FA - Katz, Ryan IN - Isken, Tonguc. Department of Plastic and Reconstructive Surgery, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. tongucisken@yahoo.com TI - Abdominal fascial flaps for providing total implant coverage in one-stage breast reconstruction: an autologous solution.[Erratum appears in Aesthetic Plast Surg. 2009 Nov;33(6):852 Note: Katz, Ryan [added]] SO - Aesthetic Plastic Surgery. 33(6):853-8, 2009 Nov AS - Aesthetic Plast Surg. 33(6):853-8, 2009 Nov NJ - Aesthetic plastic surgery VO - 33 IP - 6 PG - 853-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Abdominal Muscles/tr [Transplantation] MH - Adult MH - Aged MH - *Breast Implants MH - Fascia/tr [Transplantation] MH - Female MH - Follow-Up Studies MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Silicones MH - *Surgical Flaps MH - Treatment Outcome AB - BACKGROUND: Silicone implants are often used in immediate breast reconstruction. Complications associated with silicone-based implant reconstruction, such as capsular contracture, implant palpability, and visibility, are best avoided by placing the implant under a reliable soft-tissue cover such as the pectoralis major muscle. This muscle, however, is not always sufficient for complete coverage of the silicone implant. This is especially true for large implants. By including the fascia of the upper abdominal muscles in the reconstruction, this problem can be overcome. We describe our experience with one-stage breast reconstruction utilizing the fascia of the upper abdominal muscles to provide adequate soft-tissue coverage of the implant. AB - METHODS: This technique was used in the reconstructions of ten patients over 4 years (2005-2009). This method was selected by the operating surgeon at the time of surgery if the pectoralis major muscle was felt to be of inadequate size to provide adequate implant coverage. The pectoralis major muscle was released from its sternal and caudal attachments to the chest wall. The rectus abdominis fascia and external oblique fascia were elevated as a combined cephalic-based flap. This fascial flap was advanced cranially and sutured to the released pectoralis major muscle after insertion of the implant. AB - RESULTS: The mean size of the silicone implant was 448.2 cc and mean follow-up was 19.7 months. All implants were adequately covered with soft tissue at the end of each case. Complications included one patient with a hematoma, one patient with skin necrosis at the suture line, and one patient with an implant infection necessitating removal. AB - CONCLUSION: There are many ways to provide soft-tissue coverage of silicone breast implants in breast reconstruction. These include acellular dermis slings, polyglycolic mesh, deepithelialized skin, and muscle. The ideal soft-tissue cover would be supple, easily harvested, of minimal morbidity, of minimal cost, and preferably autologous. We feel that the technique described here has these qualities and allows for complete coverage of silicone implants. An additional benefit of this technique is that it helps to increase the definition of the inframammary sulcus. This method is a good alternative in providing implant coverage during breast reconstruction, especially when there is a large implant or small pectoralis major muscle. RN - 0 (Silicones) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-009-9384-2 PT - Journal Article ID - 10.1007/s00266-009-9384-2 [doi] PP - ppublish PH - 2008/07/23 [received] PH - 2009/06/09 [accepted] LG - English EP - 20090714 DP - 2009 Nov EZ - 2009/07/15 09:00 DA - 2011/07/16 06:00 DT - 2009/07/15 09:00 YR - 2009 ED - 20110715 RD - 20100121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19597865 <410. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20628580 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Nguyen MD AU - Chen C AU - Colakoglu S AU - Morris DJ AU - Tobias AM AU - Lee BT FA - Nguyen, Minh-Doan FA - Chen, Chen FA - Colakoglu, Salih FA - Morris, Donald J FA - Tobias, Adam M FA - Lee, Bernard T TI - Infectious Complications Leading to Explantation in Implant-Based Breast Reconstruction With AlloDerm. SO - Eplasty [Electronic Resource]. 10:e48, 2010 Jun 30 AS - Eplasty. 10:e48, 2010 Jun 30 NJ - Eplasty VO - 10 PG - e48 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900825 CP - United States AB - OBJECTIVE: The role for acellular dermal matrix in implant-based breast reconstruction-providing coverage of the inferolateral border of the underlying prosthesis and allowing control over the inframammary fold-has become increasingly popular. Although AlloDerm (LifeCell, Branchburg, NJ) is free of cellular components responsible for the antigenic response, its processing does not guarantee sterility. In this study, we examine the infectious complications in tissue expander/implant-based reconstruction with AlloDerm. AB - METHODS: A retrospective cohort analysis was completed on 321 implant-based breast reconstructions over a 10-year period (1998-2008) at an academic institution. Of these cases, 75 reconstructions used AlloDerm and 246 reconstructions did not. The incidence of infections that required readmission for intravenous (IV) antibiotics and explantation was determined. Prosthetic explants due to hematoma or patient dissatisfaction were excluded from analysis. AB - RESULTS: There were no differences in rates of readmission for IV antibiotics (2.8% vs 5.3%; P = .291). The rate of explantation due to infected fluid collections and extrusion was higher in the AlloDerm group (8.0%, n = 6) than that in the control group (1.6%, n = 4). This result was statistically significant (P = .013). AB - CONCLUSION: In this study, the rates of IV antibiotic administration for the treatment of cellulitis in implant-based breast reconstructions did not differ because of the presence of AlloDerm; however, the rate of explantation was statistically higher in reconstructions using AlloDerm. This technique has great potential in breast reconstruction, especially for single-staged implant-based reconstruction, but careful counseling of patients with regard to the higher risk of explantation is necessary. ES - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC2900825 [pmc] PP - epublish LG - English EP - 20100630 DP - 2010 Jun 30 EZ - 2010/07/16 06:00 DA - 2010/07/16 06:01 DT - 2010/07/15 06:00 YR - 2010 ED - 20110714 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=20628580 <411. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20190908 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Murray JD AU - Elwood ET AU - Jones GE AU - Barrick R AU - Feng J FA - Murray, John D FA - Elwood, Eric T FA - Jones, Glyn E FA - Barrick, Rebecca FA - Feng, Jack IN - Murray, John D. Division of Plastic Surgery, University of Illinois College of Medicine at Peoria; TI - Decreasing expander breast infection: A new drain care protocol. SO - Canadian Journal of Plastic Surgery. 17(1):17-21, 2009 AS - Can. j. plast. surg.. 17(1):17-21, 2009 NJ - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique VO - 17 IP - 1 PG - 17-21 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9434932 IO - Can J Plast Surg PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705308 CP - Canada KW - Adult; Alloderm; Breast expander; Breast implants; Breast neoplasms; Breast reconstruction; Closed suction drains; Combined modality therapy; Drains; Female; Humans; Infection; Mammaplasty; Mastectomy; Mupirocin; Tissue expansion devices AB - BACKGROUND: Risk factors for expander reconstruction infection are well known. However, drain use as a risk factor for the development of infection is unclear. AB - OBJECTIVE: To review a simple method for drain use to help reduce rates of infection in expander breast reconstruction. AB - METHODS: Two hundred consecutive single-surgeon (JDM) immediate first-stage expander breast reconstructions were retrospectively reviewed. The records were reviewed for history and physical examination, intra-operative technique, perioperative management, adjuvant therapy, and outcome with respect to expander infection necessitating premature explantation within the first eight weeks. Infection was defined on clinical basis, with or without culture positivity. All expanders (Mentor, USA) were the same model (textured, port-integrated and biodimensional). Two consecutive series of reconstructions were then created. The first series included 177 reconstructions while the second series included 23 reconstructions. Unlike the first series, the second series introduced a protocol in which all reconstructions received mupirocin 2% cream to the drain sites and all drains were removed at the end of the first week. Additionally, in the second series, all expanders were secluded from direct in vivo contact with the closed suction drain either by the use of an intervening Alloderm sling (LifeCell Corporation, USA, 15 of 23 breasts) or by subdermally tunnelling the drain superficial to an adequate fatty subcutaneous layer (eight of 23 breasts). AB - RESULTS: Patients who developed infection in the first series and all patients in the second series shared statistically the same level of aggregate risk factors (P=0.531). The infection rate (5.65%, 10 infections in 177 breasts) in the first series was statistically greater than in the second series (0%, 0 in 23 breasts, P=0.001). AB - CONCLUSIONS: The present study found that percutaneous closed suction drains do serve as an increased risk for expander infection. However, early results indicate that in vivo protection of the expander with Alloderm or subdermal tunnelling, topical antibiotic ointment use and early drain removal may significantly reduce expander infection. ES - 1918-1507 IL - 1195-2199 PT - Journal Article ID - PMC2705308 [pmc] PP - ppublish LG - English DP - 2009 EZ - 2010/03/02 06:00 DA - 2010/03/02 06:01 DT - 2010/03/02 06:00 YR - 2009 ED - 20110714 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=20190908 <412. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19526050 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Breuing KH AU - Colwell AS FA - Breuing, Karl H FA - Colwell, Amy S IN - Breuing, Karl H. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. kbreuing@partners.org TI - Immediate breast tissue expander-implant reconstruction with inferolateral AlloDerm hammock and postoperative radiation: a preliminary report. SO - Eplasty [Electronic Resource]. 9:e16, 2009 May 15 AS - Eplasty. 9:e16, 2009 May 15 NJ - Eplasty VO - 9 PG - e16 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683576 CP - United States AB - OBJECTIVE: To preserve the mastectomy skin envelope in select patients destined to receive radiation following mastectomy, we performed immediate tissue expander-implant reconstruction with a subpectoral tissue expander and an inferolateral AlloDerm hammock for complete implant coverage. We hypothesized that the AlloDerm hammock may allow greater intraoperative volume expansion and potentially avoid the need for an autologous construct. AB - METHODS: Tissue expanders were filled to 75%-85% capacity intraoperatively and 85%-100% prior to radiation therapy. This allowed for maximum preservation of the mastectomy skin envelope prior to radiation therapy and provided a sizable breast mound immediately following mastectomy. Histology of irradiated and nonirradiated capsules was compared. AB - RESULTS: Five patients aged 29-51 years had immediate implant (1) or expander-implant (4) breast reconstruction followed by postreconstruction radiation 2-6 months following the procedure. Patients were followed for 2.5-5.5 years following implant reconstruction and 2-5 years following radiation. No capsular contracture or implant loss was observed in any patient. No patients required or requested autologous reconstruction following radiation and all currently have silicone implants. Capsular biopsies from radiated and nonradiated implants showed identical collagen architecture on histology, confirming clinical observations. AB - CONCLUSION: Tissue expander-implant breast reconstruction following mastectomy preserves the skin envelope in patients who receive postmastectomy radiation. Further investigation is warranted to determine whether complete implant coverage with the pectoralis muscle and AlloDerm hammock mitigates the deleterious effects of radiation. ES - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC2683576 [pmc] PP - epublish LG - English EP - 20090515 DP - 2009 May 15 EZ - 2009/06/16 09:00 DA - 2009/06/16 09:01 DT - 2009/06/16 09:00 YR - 2009 ED - 20110714 RD - 20090615 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=19526050 <413. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21228744 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Liu AS AU - Kao HK AU - Reish RG AU - Hergrueter CA AU - May JW Jr AU - Guo L FA - Liu, Allen S FA - Kao, Huang-Kai FA - Reish, Richard G FA - Hergrueter, Charles A FA - May, James W Jr FA - Guo, Lifei IN - Liu, Allen S. Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Mass. 02115, USA. TI - Postoperative complications in prosthesis-based breast reconstruction using acellular dermal matrix. CM - Comment in: Plast Reconstr Surg. 2012 Jan;129(1):170e-171e; author reply 171e-172e; PMID: 22186542 SO - Plastic & Reconstructive Surgery. 127(5):1755-62, 2011 May AS - Plast Reconstr Surg. 127(5):1755-62, 2011 May NJ - Plastic and reconstructive surgery VO - 127 IP - 5 PG - 1755-62 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Body Mass Index MH - *Collagen/ae [Adverse Effects] MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Massachusetts/ep [Epidemiology] MH - Patient Selection MH - *Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Risk Factors MH - Skin, Artificial/ae [Adverse Effects] MH - Time Factors AB - BACKGROUND: Acellular dermal matrix has become a common adjunct in prosthesis-based breast reconstruction. The authors' aim was to determine whether acellular dermal matrix use in immediate prosthesis-based breast reconstruction is associated with higher rate of complications. AB - METHODS: Over a 51/2-year period at the Brigham and Women's Hospital, 470 postmastectomy defects were reconstructed immediately using tissue expanders or implants. These were divided into two groups: reconstructions with or without acellular dermal matrix. Data were collected on patient comorbidities, radiation, intraoperative tumescent solution use, prosthesis size, initial fill volume, and complications. AB - RESULTS: The risk for major infections that required prosthesis removal was elevated in the acellular dermal matrix group (4.9 versus 2.5 percent), but this increase did not reach statistical significance (p = 0.172). There was a statistically significant increase in overall wound infection rate in the acellular dermal matrix group (6.8 versus 2.5 percent, p = 0.031), but in a multivariate analysis, the use of acellular dermal matrix did not materialize as a significant risk factor for overall wound infection. Overall surgical complication rate was significantly higher in the acellular dermal matrix group at 19.5 percent, compared with the non-acellular dermal matrix group at 12.3 percent (p < 0.001). Other significant risk factors for overall surgical complication included smoking, higher body mass index, higher initial volume, and larger implant size. AB - CONCLUSIONS: Patient selection for prosthesis reconstruction involving acellular dermal matrix should be judicious, especially among smokers and patients with elevated body mass index. Even though the use of acellular dermal matrix allows higher initial volumes and reduced number of expansions, one should be careful about putting in too high of an initial volume. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31820cf233 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e31820cf233 [doi] PP - ppublish LG - English DP - 2011 May EZ - 2011/01/14 06:00 DA - 2011/07/06 06:00 DT - 2011/01/14 06:00 YR - 2011 ED - 20110705 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21228744 <414. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21184070 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Newman MI AU - Swartz KA AU - Samson MC AU - Mahoney CB AU - Diab K FA - Newman, Martin I FA - Swartz, Kimberly A FA - Samson, Michel C FA - Mahoney, Chris Brown FA - Diab, Khaled IN - Newman, Martin I. Department of Plastic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL 33331, USA. newmanm@ccf.org TI - The true incidence of near-term postoperative complications in prosthetic breast reconstruction utilizing human acellular dermal matrices: a meta-analysis. [Review] SO - Aesthetic Plastic Surgery. 35(1):100-6, 2011 Feb AS - Aesthetic Plast Surg. 35(1):100-6, 2011 Feb NJ - Aesthetic plastic surgery VO - 35 IP - 1 PG - 100-6 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Biocompatible Materials/ae [Adverse Effects] MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Breast Implants/ae [Adverse Effects] MH - *Breast Implants/sn [Statistics & Numerical Data] MH - Breast Neoplasms/su [Surgery] MH - Collagen/ae [Adverse Effects] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Mammaplasty/mt [Methods] MH - *Mammaplasty/sn [Statistics & Numerical Data] MH - *Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pc [Prevention & Control] MH - Risk Factors MH - Surgical Flaps MH - Surgical Wound Infection/ep [Epidemiology] MH - Tissue Expansion Devices/ae [Adverse Effects] MH - *Tissue Expansion Devices/sn [Statistics & Numerical Data] MH - Wound Healing AB - BACKGROUND: The use of human acellular dermal matrix (HADM) materials in prosthetic-based breast reconstruction has gained popularity in recent years. Questions remain, however, regarding the nature and incidence of postoperative complications associated with this technique. The results reported in the available literature vary widely. This meta-analysis examines this question further with a broad review of the available literature in an effort to better define the true nature and incidence of near-term complications associated with the use of HADM in prosthetic-based breast reconstruction. It does not aim to compare this method of reconstruction to others. AB - METHODS: A review of the available literature was performed in July 2009. The goal was to identify all previous works describing the placement of HADM at prosthetic-based breast reconstruction. Included were studies that documented the use of HADM for coverage of tissue expanders or permanent implants following therapeutic or prophylactic mastectomy. Excluded were studies that reported on the use of HADM in cosmetic breast surgery or studies that included the use of xenografts. Data collected included demographics as well as the nature and incidence of complications, with separate categories assigned for seroma, infection, flap necrosis, and "other." Data were analyzed using Comprehensive Meta-Analysis() software (Biostat, Englewood, NJ). Raw proportions, fixed-effect models, and random-effect models were used to assess the complication rates across studies. AB - RESULTS: Eleven published articles and one abstract that was later published as an article were identified. Within these 12 studies, a total of 789 breasts were identified that had undergone reconstruction with HADM. The mean follow-up was 13.7 months. Under the random-effects model, the total complication rate was 12.0%. The most common complications were flap necrosis (3.3%), seroma (3.3%), and infection (5.6%). All complications not included in these categories were set apart in a separate category, "Other," and totaled 3.0% AB - CONCLUSION: The true incidence of postoperative complications in the near term utilizing HADM in prosthetic-based breast reconstruction appears to be approximately 12%. The incidence of long-term complications such as capsular contracture remains unknown. However, as surgical experience with HADM grows, operative techniques designed at reducing risks will mature, strategies for managing complications will advance, and more advanced products designed to reduce the incidence of complications are likely to become available. RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-010-9631-6 PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review ID - 10.1007/s00266-010-9631-6 [doi] PP - ppublish PH - 2010/05/15 [received] PH - 2010/10/29 [accepted] LG - English EP - 20101224 DP - 2011 Feb EZ - 2010/12/25 06:00 DA - 2011/06/22 06:00 DT - 2010/12/25 06:00 YR - 2011 ED - 20110621 RD - 20110210 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21184070 <415. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21088648 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL AU - Seruya M AU - Clemens MW AU - Teitelbaum S AU - Nahabedian MY FA - Spear, Scott L FA - Seruya, Mitchel FA - Clemens, Mark W FA - Teitelbaum, Steven FA - Nahabedian, Maurice Y IN - Spear, Scott L. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. spears@gunet.georgetown.edu TI - Acellular dermal matrix for the treatment and prevention of implant-associated breast deformities. SO - Plastic & Reconstructive Surgery. 127(3):1047-58, 2011 Mar AS - Plast Reconstr Surg. 127(3):1047-58, 2011 Mar NJ - Plastic and reconstructive surgery VO - 127 IP - 3 PG - 1047-58 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implants/ae [Adverse Effects] MH - *Collagen MH - *Dermis/tr [Transplantation] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Reoperation MH - Retrospective Studies MH - Time Factors MH - *Tissue Expansion Devices MH - Treatment Outcome MH - Young Adult AB - BACKGROUND: Acellular dermal matrix has been increasingly accepted in prosthetic breast reconstruction. Observed benefits include improved control and support of implant position, better implant coverage, and the suggestion of a decreased capsular contracture rate. Based on this positive experience, it is not surprising that acellular dermal matrix would be applied to other challenging implant-related problems. This study investigates the use of acellular dermal matrix for correction or prevention of implant-associated breast deformities. AB - METHODS: Patients who underwent primary aesthetic breast surgery or secondary aesthetic or reconstructive breast surgery using acellular dermal matrix and implants between November of 2003 and October of 2009 were reviewed retrospectively. Patient demographics, indications for acellular dermal matrix, and acellular dermal matrix type and inset pattern were identified. Preoperative and postoperative photographs, success or failure of the procedure, complications, and need for related or unrelated revision surgery were recorded. AB - RESULTS: Fifty-two patients had acellular dermal matrix placed alongside 77 breast prostheses, with a mean follow-up of 8.6 months (range, 0.4 to 30.4 months). Indications included prevention of implant bottoming-out (n = 6), treatment of malposition (n = 32), rippling (n = 20), capsular contracture (n = 16), and skin flap deficiency (n = 16). Seventy-four breasts (96.1 percent) were managed successfully with acellular dermal matrix. Three failures consisted of one breast with bottoming-out following treatment of capsular contracture, one breast with major infection requiring device explantation, and one breast with recurrent rippling. There was a 9.1 percent total complication rate, consisting of three mild infections, one major infection necessitating explantation, one hematoma, and one seroma. AB - CONCLUSION: Based on this experience in 77 breasts, acellular dermal matrix has shown promise in treating and preventing capsular contracture, rippling, implant malposition, and soft-tissue thinning. RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31820436af PT - Journal Article ID - 10.1097/PRS.0b013e31820436af [doi] PP - ppublish LG - English DP - 2011 Mar EZ - 2010/11/23 06:00 DA - 2011/04/27 06:00 DT - 2010/11/20 06:00 YR - 2011 ED - 20110426 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21088648 <416. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20978439 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Roostaeian J AU - Crisera C FA - Roostaeian, Jason FA - Crisera, Christopher IN - Roostaeian, Jason. Division of Plastic and Reconstructive Surgery, University of California Los Angeles, Los Angeles, California 90095, USA. TI - Current options in breast reconstruction with or without radiotherapy. [Review] SO - Current Opinion in Obstetrics & Gynecology. 23(1):44-50, 2011 Feb AS - Curr Opin Obstet Gynecol. 23(1):44-50, 2011 Feb NJ - Current opinion in obstetrics & gynecology VO - 23 IP - 1 PG - 44-50 PI - Journal available in: Print PI - Citation processed from: Internet JC - a50, 9007264 IO - Curr. Opin. Obstet. Gynecol. SB - Index Medicus CP - England MH - Biomedical Technology MH - Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/rt [Radiotherapy] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Transplantation, Autologous AB - PURPOSE OF REVIEW: A brief overview of the current options in breast reconstruction with special consideration given to the effect of radiotherapy is presented. AB - RECENT FINDINGS: Breast reconstruction is an important part of the overall care of mastectomy patients. Studies have demonstrated improved psychological well being, better quality of life, and most recently increased survival in women who have undergone breast reconstruction. Advancements such as nipple and skin sparing mastectomies, acellular dermal matrix, and improved implant technology have improved the results of implant-based breast reconstruction. The development of perforator flaps has further minimized donor-site morbidity with autologous tissue breast reconstruction. Despite much progress, difficulties remain in the management of patients with locally advanced breast cancer who will require radiation. AB - SUMMARY: Informed physician counseling of current breast reconstruction options is an integral part of the overall care of patients undergoing mastectomy. Special consideration needs to be made for patients with locally advanced breast cancer who require radiotherapy. ES - 1473-656X IL - 1040-872X DO - https://dx.doi.org/10.1097/GCO.0b013e328340e18a PT - Journal Article PT - Review ID - 10.1097/GCO.0b013e328340e18a [doi] PP - ppublish LG - English DP - 2011 Feb EZ - 2010/10/28 06:00 DA - 2011/04/19 06:00 DT - 2010/10/28 06:00 YR - 2011 ED - 20110418 RD - 20101230 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=20978439 <417. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21285756 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA AU - Ashikari AY AU - Koch RM AU - Chabner-Thompson E FA - Salzberg, C Andrew FA - Ashikari, Andrew Y FA - Koch, R Michael FA - Chabner-Thompson, Elizabeth IN - Salzberg, C Andrew. Division of Plastic Surgery, New York Medical College, New York, NY, USA. asalzbergmd@yahoo.com TI - An 8-year experience of direct-to-implant immediate breast reconstruction using human acellular dermal matrix (AlloDerm). SO - Plastic & Reconstructive Surgery. 127(2):514-24, 2011 Feb AS - Plast Reconstr Surg. 127(2):514-24, 2011 Feb NJ - Plastic and reconstructive surgery VO - 127 IP - 2 PG - 514-24 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implantation/mt [Methods] MH - Breast Neoplasms/pc [Prevention & Control] MH - Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Male MH - Retrospective Studies MH - *Skin, Artificial AB - BACKGROUND: The advent of skin- and nipple-sparing mastectomy in conjunction with the use of human acellular dermal matrix to provide lower pole coverage has made direct-to-implant immediate breast reconstruction following mastectomy feasible. The purpose of this study was to evaluate long-term complications associated with this technique. AB - METHODS: All human acellular dermal matrix-assisted direct-to-implant immediate reconstructions performed over an 8-year period were included in this analysis. Patient charts were reviewed for type of mastectomy (oncologic or prophylactic), incision type, complications during follow-up, length of follow-up, rate and type of revision surgery in breasts without postoperative complications, contralateral procedures, and adjuvant radiotherapy. AB - RESULTS: A total of 466 breasts (260 patients) were reconstructed; 68 percent were prophylactic and 32 percent were oncologic cases. Twenty-one breasts (4.5 percent) received radiotherapy. Mean implant size placed was 412.8 +/- 24.7 cc (range, 150 to 600 cc). Mean follow-up was 28.9 +/- 21.3 months (range, 0.3 to 97.7 months). The overall complication rate was 3.9 percent (implant loss, 1.3 percent; skin breakdown/necrosis, 1.1 percent; hematoma, 1.1 percent; human acellular dermal matrix exposure, 0.6 percent; capsular contracture, 0.4 percent; and infection, 0.2 percent). Type, incidence, and overall rate of complications did not differ significantly between prophylactic and oncologic breasts. Irradiated breasts had a fourfold higher rate of complications. In 354 breasts with more than 1 year of follow-up (mean, 36.7 +/- 18.6 months; range, 12.1 to 97.7 months), there were no long-term complications. AB - CONCLUSIONS: Human acellular dermal matrix-assisted direct-to-implant breast reconstruction following mastectomy is safe and reliable, with a low overall long-term complication rate. The low incidence of capsular contracture supports the growing body of evidence that human acellular dermal matrix mitigates capsular contracture. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318200a961 PT - Journal Article ID - 10.1097/PRS.0b013e318200a961 [doi] ID - 00006534-201102000-00004 [pii] PP - ppublish LG - English DP - 2011 Feb EZ - 2011/02/03 06:00 DA - 2011/04/16 06:00 DT - 2011/02/03 06:00 YR - 2011 ED - 20110414 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21285756 <418. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20602099 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Brown RH AU - Izaddoost S AU - Bullocks JM FA - Brown, Rodger H FA - Izaddoost, Shayan FA - Bullocks, Jamal M IN - Brown, Rodger H. Baylor College of Medicine, Clinical Care Center, Houston, TX 77030, USA. Rb140110@bcm.edu TI - Preventing the "bottoming out" and "star-gazing" phenomena in inferior pedicle breast reduction with an acellular dermal matrix internal brassiere. CM - Comment in: Aesthetic Plast Surg. 2010 Dec;34(6):768; PMID: 20585947 SO - Aesthetic Plastic Surgery. 34(6):760-7, 2010 Dec AS - Aesthetic Plast Surg. 34(6):760-7, 2010 Dec NJ - Aesthetic plastic surgery VO - 34 IP - 6 PG - 760-7 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adult MH - *Breast Diseases/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Nipples/su [Surgery] MH - Patient Satisfaction MH - Treatment Outcome AB - BACKGROUND: The phenomena of "bottoming out" (pseudoptosis) and "star-gazing" (the upward rotation of the nipple-areola complex) is a common postoperative problem when using the inferior pedicle breast reduction technique. Multiple techniques have been described to help prevent this problem, including internal suspension techniques and the use of mesh to support the pedicle. We describe our technique and present a case series in which acellular dermal matrix (AlloDerm()) is used as an internal brassiere or sling to support the inferior pedicle and prevent postoperative "bottoming out" and "star-gazing." AB - METHODS: Twenty-seven patients underwent inferior pedicle reduction mammaplasty through a Wise pattern performed by a single surgeon. In each case, acellular dermal matrix (0.79-2.03 mm thick) was sutured to the chest wall as a sling or internal brassiere to support the inferior pedicle. The pedicle was also plicated in a horizontal fashion to increase the projection of the breast and to improve the position of the nipple-areola complex. AB - RESULTS: The mean weight of reduction per breast was 850 g. The mean distance from the nipple to the inframammary fold was 16.4 cm. The mean distance from the sternal notch to the nipple was 32.2 cm. Only one patient developed cellulitis and one patient had partial skin flap necrosis. There was no nipple loss. At routine follow-up it was found that the aesthetic breast shape has been retained and pseudoptosis or "bottoming out" was not significant in any patient. The longest follow-up is 29 months. AB - CONCLUSION: The use of an acellular dermal matrix internal brassiere is a safe and effective technique for preventing the "bottoming out" and "star-gazing" phenomena that occurs after inferior pedicle breast reduction. Longer-term follow-up will be required to assess the longevity of these results. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-010-9538-2 PT - Journal Article ID - 10.1007/s00266-010-9538-2 [doi] PP - ppublish PH - 2010/01/27 [received] PH - 2010/05/18 [accepted] LG - English EP - 20100703 DP - 2010 Dec EZ - 2010/07/06 06:00 DA - 2011/03/30 06:00 DT - 2010/07/06 06:00 YR - 2010 ED - 20110329 RD - 20101130 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20602099 <419. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20585947 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Goes JC FA - Goes, Joao Carlos Sampaio IN - Goes, Joao Carlos Sampaio. clinica@sampaiogoes.com TI - Preventing the "bottoming out and star-gazing" phenomenon in inferior pedicle breast reduction with an acellular dermal matrix internal brassiere. CM - Comment on: Aesthetic Plast Surg. 2010 Dec;34(6):760-7; PMID: 20602099 SO - Aesthetic Plastic Surgery. 34(6):768, 2010 Dec AS - Aesthetic Plast Surg. 34(6):768, 2010 Dec NJ - Aesthetic plastic surgery VO - 34 IP - 6 PG - 768 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - *Breast Diseases/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Esthetics MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Nipples/su [Surgery] MH - Treatment Outcome RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-010-9539-1 PT - Comment PT - Journal Article ID - 10.1007/s00266-010-9539-1 [doi] PP - ppublish PH - 2010/03/22 [received] PH - 2010/03/22 [accepted] LG - English EP - 20100629 DP - 2010 Dec EZ - 2010/06/30 06:00 DA - 2011/03/30 06:00 DT - 2010/06/30 06:00 YR - 2010 ED - 20110329 RD - 20101130 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20585947 <420. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21078486 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Buck DW 2nd AU - Shenaq D AU - Heyer K AU - Kato C AU - Kim JY FA - Buck, Donald W 2nd FA - Shenaq, Deana FA - Heyer, Kamaldeep FA - Kato, Caroline FA - Kim, John Y S IN - Buck, Donald W 2nd. Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, 675 North St Clair Street, Galter Suite 19-250, Chicago, IL 60611, United States. TI - Patient-subjective cosmetic outcomes following the varying stages of tissue expander breast reconstruction: the importance of completion. SO - Breast. 19(6):521-6, 2010 Dec AS - BREAST. 19(6):521-6, 2010 Dec NJ - Breast (Edinburgh, Scotland) VO - 19 IP - 6 PG - 521-6 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9213011 IO - Breast SB - Index Medicus CP - Netherlands MH - Breast/ah [Anatomy & Histology] MH - Breast/su [Surgery] MH - Breast Implants MH - Dermis/tr [Transplantation] MH - *Esthetics/px [Psychology] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mammaplasty/px [Psychology] MH - Middle Aged MH - Nipples/ah [Anatomy & Histology] MH - Nipples/su [Surgery] MH - *Patient Satisfaction MH - Statistics, Nonparametric MH - Surveys and Questionnaires MH - *Tissue Expansion Devices MH - Treatment Outcome AB - INTRODUCTION: Tissue expander breast reconstruction consists of three major surgical steps: placement of the expander after mastectomy, exchange of the expander for an implant, and nipple-areola complex reconstruction. The evolution of patient satisfaction throughout this process has not been evaluated. Here we performed a stratified analysis of patient-subjective cosmetic outcomes during the stages of breast reconstruction. AB - METHODS: Twenty-eight consecutive tissue expander-implant reconstructions were performed by the senior author using human acellular dermis. Cosmetic outcomes were assessed after each reconstructive stage using a validated Breast Evaluation Questionnaire consisting of questions related to breast size, shape and firmness in three separate contexts: intimate or sexual activities, leisure or social activities, and professional or job-related activities. AB - RESULTS: Eighteen patients underwent unilateral reconstruction, while 10 underwent bilateral reconstruction. Satisfaction scores were statistically higher following Stage I and II procedures for bilateral reconstructions. For unilateral reconstructions, there was a statistically significant elevation in scores following Stage II. The addition of nipple-areola reconstruction resulted in the highest scores for both unilateral and bilateral reconstructions. These score elevations were significant (p < 0.05) in nearly every measured context for unilateral reconstructions and as such, the significant differences in scores between unilateral and bilateral cohorts after stages I and II were nearly eliminated after completion of the entire reconstructive process. AB - CONCLUSION: Satisfaction with tissue expander reconstruction is significantly affected by the patients' stage during the reconstructive process. Completion of all three stages, including nipple-areolar complex reconstruction, achieves maximal patient satisfaction. For unilateral reconstructions, completion of the entire reconstructive process, including contralateral symmetry procedures and nipple-areolar complex reconstruction, results in cosmesis scores that are similar to those in bilateral cases. Copyright © 2010 Elsevier Ltd. All rights reserved. ES - 1532-3080 IL - 0960-9776 DO - https://dx.doi.org/10.1016/j.breast.2010.05.017 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - S0960-9776(10)00149-9 [pii] ID - 10.1016/j.breast.2010.05.017 [doi] PP - ppublish PH - 2009/10/28 [received] PH - 2010/03/18 [revised] PH - 2010/05/25 [accepted] LG - English EP - 20100617 DP - 2010 Dec EZ - 2010/11/17 06:00 DA - 2011/03/25 06:00 DT - 2010/11/17 06:00 YR - 2010 ED - 20110324 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=21078486 <421. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21200253 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y TI - Acellular human dermis implantation in 153 immediate two-stage tissue expander breast reconstructions: determining the incidence and significant predictors of complications. CM - Comment on: Plast Reconstr Surg. 2010 Jun;125(6):1606-14; PMID: 20517083 SO - Plastic & Reconstructive Surgery. 127(1):481-2; author reply 482-3, 2011 Jan AS - Plast Reconstr Surg. 127(1):481-2; author reply 482-3, 2011 Jan NJ - Plastic and reconstructive surgery VO - 127 IP - 1 PG - 481-2; author reply 482-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Implantation MH - *Dermis/tr [Transplantation] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Tissue Expansion Devices MH - Treatment Failure ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181fad5cc PT - Comment PT - Comparative Study PT - Letter ID - 10.1097/PRS.0b013e3181fad5cc [doi] ID - 00006534-201101000-00074 [pii] PP - ppublish LG - English DP - 2011 Jan EZ - 2011/01/05 06:00 DA - 2011/02/04 06:00 DT - 2011/01/05 06:00 YR - 2011 ED - 20110203 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med7&AN=21200253 <422. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20633009 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Staton CA AU - Valluru M AU - Hoh L AU - Reed MW AU - Brown NJ FA - Staton, C A FA - Valluru, M FA - Hoh, L FA - Reed, M W R FA - Brown, N J IN - Staton, C A. Microcirculation Research Group, Academic Unit of Surgical Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2RX, UK. c.a.staton@shef.ac.uk TI - Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring. SO - British Journal of Dermatology. 163(5):920-7, 2010 Nov AS - Br J Dermatol. 163(5):920-7, 2010 Nov NJ - The British journal of dermatology VO - 163 IP - 5 PG - 920-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - aw0, 0004041 IO - Br. J. Dermatol. SB - Index Medicus CP - England MH - *Angiopoietin-1/me [Metabolism] MH - *Angiopoietin-2/me [Metabolism] MH - Biopsy MH - *Cicatrix/me [Metabolism] MH - Cicatrix/pa [Pathology] MH - Endothelial Cells/me [Metabolism] MH - Female MH - Fibroblasts/me [Metabolism] MH - Humans MH - Immunohistochemistry MH - Myofibroblasts/me [Metabolism] MH - *Neovascularization, Physiologic/ph [Physiology] MH - *Receptor, TIE-2/me [Metabolism] MH - *Skin/me [Metabolism] MH - Skin/pa [Pathology] MH - Vascular Endothelial Growth Factor A/me [Metabolism] MH - *Wound Healing/ph [Physiology] AB - BACKGROUND: The angiopoietin (Ang)/Tie-2 ligand/receptor system is known to interact with the vascular endothelial growth factor (VEGF) pathway to determine the fate of blood vessels during angiogenesis. However, the precise contribution of this system to angiogenesis and the mechanisms of vascular maturation and remodelling in human tissue repair have yet to be elucidated. AB - OBJECTIVES: To examine the spatial and temporal expression of Ang-1, Ang-2, Tie-2 and VEGF in relation to angiogenesis in human surgical wounds. AB - METHODS: Punch biopsies were taken either from normal unwounded skin (controls) during surgery or from mastectomy scars between 3 days and 2 years postsurgery. Ang-1, Ang-2, Tie-2 and VEGF fibroblast/myofibroblast and endothelial expression were characterized by immunohistochemistry, analysed semiquantitatively and correlated with microvessel density (MVD) and scar age. AB - RESULTS: The expression of VEGF, Ang-1, Ang-2 and Tie-2 in fibroblasts/myofibroblasts was increased significantly in early scars, decreased in older scars and was related to scar age (P < 0.001) and MVD (P < 0.0004), with strong correlations between all factors. In contrast, vascular expression of Ang-1 was decreased slightly in early scars, vascular Ang-2 remained constant and Tie-2 vascular expression increased, although there were no correlations with scar age or MVD. AB - CONCLUSIONS: These data demonstrate that angiopoietins and their receptor, Tie-2, are expressed in both fibroblasts/myofibroblasts and endothelial cells in healing human wounds. Fibroblast/myofibroblast expression correlates with angiogenesis and VEGF expression, suggesting a role for the angiopoietin/Tie-2 system in normal wound repair and scarring. Copyright © 2010 The Authors. BJD © 2010 British Association of Dermatologists. RN - 0 (Angiopoietin-1) RN - 0 (Angiopoietin-2) RN - 0 (Vascular Endothelial Growth Factor A) RN - EC 2-7-10-1 (Receptor, TIE-2) ES - 1365-2133 IL - 0007-0963 DO - https://dx.doi.org/10.1111/j.1365-2133.2010.09940.x PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - BJD9940 [pii] ID - 10.1111/j.1365-2133.2010.09940.x [doi] PP - ppublish LG - English DP - 2010 Nov EZ - 2010/07/17 06:00 DA - 2011/01/11 06:00 DT - 2010/07/17 06:00 YR - 2010 ED - 20110110 RD - 20101027 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20633009 <423. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21124125 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Basu CB AU - Leong M AU - Hicks MJ FA - Basu, C Bob FA - Leong, Mimi FA - Hicks, M John IN - Basu, C Bob. Institute of Advanced Breast Reconstruction, the Section of Plastic Surgery, Michael E. DeBakey Veterans Affairs Medical Center, and the Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. drbasu@basuplasticsurgery.com TI - Acellular cadaveric dermis decreases the inflammatory response in capsule formation in reconstructive breast surgery. SO - Plastic & Reconstructive Surgery. 126(6):1842-7, 2010 Dec AS - Plast Reconstr Surg. 126(6):1842-7, 2010 Dec NJ - Plastic and reconstructive surgery VO - 126 IP - 6 PG - 1842-7 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Biopsy MH - Breast/pa [Pathology] MH - *Breast Implantation/mt [Methods] MH - *Breast Neoplasms/su [Surgery] MH - Case-Control Studies MH - *Collagen MH - Female MH - Fibrosis/pa [Pathology] MH - *Fibrosis/pc [Prevention & Control] MH - Foreign-Body Reaction/pa [Pathology] MH - *Foreign-Body Reaction/pc [Prevention & Control] MH - Humans MH - Middle Aged MH - Postoperative Complications/pa [Pathology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Reoperation/mt [Methods] MH - Tissue Expansion/mt [Methods] AB - BACKGROUND: Acellular cadaveric dermis in implant-based breast reconstruction provides an alternative to total submuscular placement. To date, there has been no detailed in vivo human analysis of the histopathologic sequelae of acellular cadaveric dermis in implant-based breast reconstruction. Based on clinical observations, we hypothesize that acellular cadaveric dermis decreases the inflammatory response and foreign body reaction normally seen around breast implants. AB - METHODS: Twenty patients underwent tissue expander reconstruction using the "dual-plane" acellular cadaveric dermis technique (AlloDerm). During implant exchange, intraoperative biopsy specimens were obtained of (1) biointegrated acellular cadaveric dermis and (2) native subpectoral capsule (internal control). Histopathologic analysis was performed. Masked biopsy specimens were scored semiquantitatively by an experienced histopathologist to reflect observed granulation tissue formation, vessel proliferation, chronic inflammatory changes, capsule fibrosis, fibroblast cellularity, and foreign body giant cell inflammatory reaction. Scores were analyzed statistically using the Wilcoxon signed rank test. AB - RESULTS: Acellular cadaveric dermis (AlloDerm) had statistically diminished levels for all parameters compared with corresponding native breast capsules (p<0.001). AB - CONCLUSIONS: This represents the first detailed histopathologic comparative analysis between biointegrated acellular cadaveric dermis and native capsules in implant-based breast reconstruction. These histopathologic findings suggest that certain properties intrinsic to acellular cadaveric dermis may limit capsule formation by diminishing inflammatory changes that initiate capsule formation. Further investigation is needed to determine whether acellular cadaveric dermis reduces the incidence of breast capsular contracture. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181f44674 PT - Controlled Clinical Trial PT - Journal Article ID - 10.1097/PRS.0b013e3181f44674 [doi] ID - 00006534-201012000-00006 [pii] PP - ppublish LG - English DP - 2010 Dec EZ - 2010/12/03 06:00 DA - 2011/01/08 06:00 DT - 2010/12/03 06:00 YR - 2010 ED - 20110107 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=21124125 <424. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21105625 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tran Cao HS AU - Tokin C AU - Konop J AU - Ojeda-Fournier H AU - Chao J AU - Blair SL FA - Tran Cao, Hop S FA - Tokin, Christopher FA - Konop, Jason FA - Ojeda-Fournier, Haydee FA - Chao, James FA - Blair, Sarah L IN - Tran Cao, Hop S. University of California, San Diego Medical Center, San Diego, California 92093-0987, USA. TI - A preliminary report on the clinical experience with AlloDerm in breast reconstruction and its radiologic appearance. SO - American Surgeon. 76(10):1123-6, 2010 Oct AS - Am Surg. 76(10):1123-6, 2010 Oct NJ - The American surgeon VO - 76 IP - 10 PG - 1123-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 43e, 0370522 IO - Am Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Neoplasms/dt [Drug Therapy] MH - *Breast Neoplasms/su [Surgery] MH - Chemotherapy, Adjuvant MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - *Mammaplasty/mt [Methods] MH - *Mammography MH - Mastectomy, Segmental MH - Middle Aged MH - Retrospective Studies MH - *Skin, Artificial AB - Human acellular tissue matrix (AlloDerm) use in breast reconstruction has become popular. Traditionally used for prosthesis coverage, it is also used in our practice as a filler for lumpectomy defects and a contouring device. However, no report presently exists that describes its appearance on oncologic surveillance studies. We performed a retrospective review of all charts of patients having undergone cancer-related breast reconstruction using AlloDerm as a filler at a single institution between 2005 and 2009. Postoperative mammograms and dynamic contrast enhanced breast magnetic resonance imaging were reviewed with a dedicated breast imager. Sixteen women underwent surgery involving placement of an AlloDerm roll in the breast. Postoperative films were unavailable for two of them. Of the remaining 14 patients, nine had postoperative mammograms only, three had postoperative dynamic contrast enhanced breast magnetic resonance imaging only, and two patients had both. In all cases, evaluation of the postoperative images was not affected by the presence of AlloDerm. In our short-term, retrospective experience, we find that a thorough radiographic evaluation of the breast tissue remains possible when AlloDerm rolls are used in reconstruction. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 0003-1348 IL - 0003-1348 PT - Journal Article PP - ppublish LG - English DP - 2010 Oct EZ - 2010/11/26 06:00 DA - 2011/01/05 06:00 DT - 2010/11/26 06:00 YR - 2010 ED - 20110104 RD - 20101125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=21105625 <425. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20885218 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Curtis MS AU - Mahmood F AU - Nguyen MD AU - Lee BT FA - Curtis, Michael S FA - Mahmood, Faraz FA - Nguyen, Minh-Doan FA - Lee, Bernard T IN - Curtis, Michael S. Department of Surgery, Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. TI - Use of AlloDerm for correction of symmastia. SO - Plastic & Reconstructive Surgery. 126(4):192e-193e, 2010 Oct AS - Plast Reconstr Surg. 126(4):192e-193e, 2010 Oct NJ - Plastic and reconstructive surgery VO - 126 IP - 4 PG - 192e-193e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Breast Diseases/et [Etiology] MH - Breast Diseases/th [Therapy] MH - *Breast Implants/ae [Adverse Effects] MH - Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/su [Surgery] MH - Chemotherapy, Adjuvant MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Postoperative Care/mt [Methods] MH - Postoperative Complications/su [Surgery] MH - Reoperation/mt [Methods] MH - Skin, Artificial MH - Treatment Outcome RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) RS - Symmastia ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181ea92a3 PT - Case Reports PT - Journal Article ID - 10.1097/PRS.0b013e3181ea92a3 [doi] ID - 00006534-201010000-00061 [pii] PP - ppublish LG - English DP - 2010 Oct EZ - 2010/10/05 06:00 DA - 2010/12/14 06:00 DT - 2010/10/02 06:00 YR - 2010 ED - 20101210 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20885218 <426. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20885216 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ellsworth WA AU - Rizvi M AU - Lypka M AU - Bass BL AU - Friedman JD FA - Ellsworth, Warren A FA - Rizvi, Mort FA - Lypka, Mike FA - Bass, Barbara L FA - Friedman, Jeffrey D IN - Ellsworth, Warren A. Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas, USA. we042844@bcm.edu TI - Breast Implant Salvage with the Use of Acellular Dermal Matrix following Partial Mastectomy. SO - Plastic & Reconstructive Surgery. 126(4):189e-190e, 2010 Oct AS - Plast Reconstr Surg. 126(4):189e-190e, 2010 Oct NJ - Plastic and reconstructive surgery VO - 126 IP - 4 PG - 189e-190e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Breast Implantation/mt [Methods] MH - *Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Carcinoma, Ductal, Breast/pa [Pathology] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Segmental/mt [Methods] MH - Middle Aged MH - *Salvage Therapy/mt [Methods] MH - Treatment Outcome RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181ea9267 PT - Case Reports PT - Journal Article ID - 10.1097/PRS.0b013e3181ea9267 [doi] ID - 00006534-201010000-00059 [pii] PP - ppublish LG - English DP - 2010 Oct EZ - 2010/10/05 06:00 DA - 2010/12/14 06:00 DT - 2010/10/02 06:00 YR - 2010 ED - 20101210 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20885216 <427. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21042149 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kim N AU - McCue JD AU - Cunningham BL FA - Kim, Nicholas FA - McCue, Jonathan D FA - Cunningham, Bruce L TI - A commentary on acellular dermal matrix in preventing capsule formation around implants in a primate model. CM - Comment on: Plast Reconstr Surg. 2009 Jul;124(1):82-91; PMID: 19568048 SO - Plastic & Reconstructive Surgery. 126(5):1791-2; author reply 1792-3, 2010 Nov AS - Plast Reconstr Surg. 126(5):1791-2; author reply 1792-3, 2010 Nov NJ - Plastic and reconstructive surgery VO - 126 IP - 5 PG - 1791-2; author reply 1792-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Animals MH - *Breast Implants/ae [Adverse Effects] MH - Cercopithecus aethiops MH - *Collagen RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181ef9261 PT - Comment PT - Letter ID - 10.1097/PRS.0b013e3181ef9261 [doi] ID - 00006534-201011000-00060 [pii] PP - ppublish LG - English DP - 2010 Nov EZ - 2010/11/03 06:00 DA - 2010/12/14 06:00 DT - 2010/11/03 06:00 YR - 2010 ED - 20101130 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=21042149 <428. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21042129 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University, Washington, DC 20007, USA. drnahabedian@aol.com TI - Discussion. The use of human acellular dermal matrix for the correction of secondary deformities after breast augmentation: results and costs. SO - Plastic & Reconstructive Surgery. 126(5):1721-2, 2010 Nov AS - Plast Reconstr Surg. 126(5):1721-2, 2010 Nov NJ - Plastic and reconstructive surgery VO - 126 IP - 5 PG - 1721-2 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Biocompatible Materials/ad [Administration & Dosage] MH - *Breast Implantation MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Reoperation RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181ef91a9 PT - Journal Article ID - 10.1097/PRS.0b013e3181ef91a9 [doi] ID - 00006534-201011000-00038 [pii] PP - ppublish LG - English DP - 2010 Nov EZ - 2010/11/03 06:00 DA - 2010/12/14 06:00 DT - 2010/11/03 06:00 YR - 2010 ED - 20101130 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=21042129 <429. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 21042128 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hartzell TL AU - Taghinia AH AU - Chang J AU - Lin SJ AU - Slavin SA FA - Hartzell, Tristan L FA - Taghinia, Amir H FA - Chang, Jerry FA - Lin, Samuel J FA - Slavin, Sumner A IN - Hartzell, Tristan L. Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02446, USA. TI - The use of human acellular dermal matrix for the correction of secondary deformities after breast augmentation: results and costs. SO - Plastic & Reconstructive Surgery. 126(5):1711-20, 2010 Nov AS - Plast Reconstr Surg. 126(5):1711-20, 2010 Nov NJ - Plastic and reconstructive surgery VO - 126 IP - 5 PG - 1711-20 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Biocompatible Materials/ad [Administration & Dosage] MH - *Breast Implantation MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Middle Aged MH - Reoperation MH - Young Adult AB - BACKGROUND: Secondary breast deformities following breast augmentation constitute some of the most challenging and difficult problems to correct. Although the application and efficacy of human acellular dermal matrix in breast reconstruction has been previously reported, there is little information in the literature relating to its indications, results, or cost in aesthetic breast surgery. AB - METHODS: This study retrospectively reviewed a single surgeon's experience in correcting secondary deformities with human acellular dermal matrix after breast augmentation from 2005 to 2009. A total of 23 patients (38 breasts) were included in the study. AB - RESULTS: There were 28 breasts with surface irregularities and 22 breasts with implant malposition (12 had both). On average, 1.13 sheets of human acellular dermal matrix were used per breast per operation. At the authors' institution, this material equates to a cost to the patient of $3536 to $4856 per breast (depending on sheet size and thickness). Twenty of 23 patients (87 percent) [32 of 38 breasts (84 percent)] had improvement in their breast deformity after breast revision surgery. Three patients (six breasts) needed another cosmetic breast operation before the end of the follow-up period: two because of persistent surface irregularities and one with a request for larger implants. One patient (3 percent) had an infection in one breast, requiring removal of the human acellular dermal matrix. AB - CONCLUSIONS: Human acellular dermal matrix is a useful and safe adjunct for correction of contour deformities after breast augmentation. Its high cost, however, may be a deterrent to widespread use in self-pay patients. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181ef900c PT - Journal Article ID - 10.1097/PRS.0b013e3181ef900c [doi] ID - 00006534-201011000-00037 [pii] PP - ppublish LG - English DP - 2010 Nov EZ - 2010/11/03 06:00 DA - 2010/12/14 06:00 DT - 2010/11/03 06:00 YR - 2010 ED - 20101130 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=21042128 <430. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20811255 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H FA - Sbitany, Hani TI - Techniques to reduce seroma and infection in acellular dermis-assisted prosthetic breast reconstruction. CM - Comment on: Plast Reconstr Surg. 2010 Feb;125(2):429-36; PMID: 20124828 SO - Plastic & Reconstructive Surgery. 126(3):1121-2; author reply 1122, 2010 Sep AS - Plast Reconstr Surg. 126(3):1121-2; author reply 1122, 2010 Sep NJ - Plastic and reconstructive surgery VO - 126 IP - 3 PG - 1121-2; author reply 1122 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants/ae [Adverse Effects] MH - *Collagen/ae [Adverse Effects] MH - Humans MH - Seroma/et [Etiology] MH - *Seroma/pc [Prevention & Control] MH - Surgical Wound Infection/et [Etiology] MH - *Surgical Wound Infection/pc [Prevention & Control] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181e3b795 PT - Comment PT - Letter ID - 10.1097/PRS.0b013e3181e3b795 [doi] ID - 00006534-201009000-00059 [pii] PP - ppublish LG - English DP - 2010 Sep EZ - 2010/09/03 06:00 DA - 2010/10/05 06:00 DT - 2010/09/03 06:00 YR - 2010 ED - 20101004 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20811255 <431. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20811254 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Newman MI AU - Hanabergh E AU - Samson MC FA - Newman, Martin I FA - Hanabergh, Enrique FA - Samson, Michel C TI - AlloDerm performance in the setting of prosthetic breast surgery, infection, and irradiation. CM - Comment on: Plast Reconstr Surg. 2009 Dec;124(6):1743-53; PMID: 19952629 SO - Plastic & Reconstructive Surgery. 126(3):1120; author reply 1120-1, 2010 Sep AS - Plast Reconstr Surg. 126(3):1120; author reply 1120-1, 2010 Sep NJ - Plastic and reconstructive surgery VO - 126 IP - 3 PG - 1120; author reply 1120-1 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Diseases/et [Etiology] MH - *Breast Implantation/ae [Adverse Effects] MH - *Breast Implants/ae [Adverse Effects] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - *Breast Neoplasms MH - *Collagen/ae [Adverse Effects] MH - Female MH - Humans MH - *Surgical Wound Infection/et [Etiology] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181e60652 PT - Comment PT - Letter ID - 10.1097/PRS.0b013e3181e60652 [doi] ID - 00006534-201009000-00057 [pii] PP - ppublish LG - English DP - 2010 Sep EZ - 2010/09/03 06:00 DA - 2010/10/05 06:00 DT - 2010/09/03 06:00 YR - 2010 ED - 20101004 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20811254 <432. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20595842 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Uflacker AB AU - Janis JE FA - Uflacker, Andre B FA - Janis, Jeffrey E TI - The use of acellular dermal matrix in the correction of visible parasternal deformities after breast reconstruction. SO - Plastic & Reconstructive Surgery. 126(1):34e-36e, 2010 Jul AS - Plast Reconstr Surg. 126(1):34e-36e, 2010 Jul NJ - Plastic and reconstructive surgery VO - 126 IP - 1 PG - 34e-36e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Biocompatible Materials MH - *Breast Neoplasms/su [Surgery] MH - *Carcinoma/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy/ae [Adverse Effects] MH - Mastectomy/mt [Methods] MH - Pectoralis Muscles/su [Surgery] MH - *Postoperative Complications/su [Surgery] MH - Sternum MH - Surgical Flaps MH - *Thoracic Wall/su [Surgery] RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181dab369 PT - Case Reports PT - Letter ID - 10.1097/PRS.0b013e3181dab369 [doi] ID - 00006534-201007000-00061 [pii] PP - ppublish LG - English DP - 2010 Jul EZ - 2010/07/03 06:00 DA - 2010/09/03 06:00 DT - 2010/07/03 06:00 YR - 2010 ED - 20100902 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20595842 <433. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20395795 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Lanier ST AU - Wang ED AU - Chen JJ AU - Arora BP AU - Katz SM AU - Gelfand MA AU - Khan SU AU - Dagum AB AU - Bui DT FA - Lanier, Steven T FA - Wang, Eric D FA - Chen, John J FA - Arora, Balvant P FA - Katz, Steven M FA - Gelfand, Mark A FA - Khan, Sami U FA - Dagum, Alexander B FA - Bui, Duc T IN - Lanier, Steven T. Stony Brook University School of Medicine, Stony Brook, NY, USA. TI - The effect of acellular dermal matrix use on complication rates in tissue expander/implant breast reconstruction. SO - Annals of Plastic Surgery. 64(5):674-8, 2010 May AS - Ann Plast Surg. 64(5):674-8, 2010 May NJ - Annals of plastic surgery VO - 64 IP - 5 PG - 674-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Biocompatible Materials MH - *Breast Implantation/mt [Methods] MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Necrosis MH - *Postoperative Complications/ep [Epidemiology] MH - Retrospective Studies MH - *Tissue Expansion Devices MH - Treatment Outcome AB - Tissue expander/implant breast reconstructions by 5 surgeons at a single institution from 2005 to 2008 were retrospectively identified and divided into 2 cohorts: use of acellular dermal matrix (ADM, n = 75) versus standard submuscular placement (n = 52). The ADM group had a statistically significant higher rate of infection (28.9% vs. 12.0%, P = 0.022), reoperation (25.0% vs. 8.0%, P = 0.011), expander explantation (19.2% vs. 5.3%, P = 0.020), and overall complications (46.2% vs. 22.7%, P = 0.007). When stratifying by breast size, a higher complication rate was not observed with the use of ADM in breasts less than 600 g, whereas ADM use in breasts larger than 600 g was associated with a statistically significant higher rate of infection when controlling for the occurrence of skin necrosis. The ADM cohort had a significantly higher mean initial tissue expander fill volume (256 mL vs. 74 mL, P < 0.001) and a significantly higher mean initial tissue expander fill ratio (49% vs. 17%, P < 0.001). Further work is needed to define the ideal patient population for ADM use in tissue expander/implant breast reconstruction. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3181dba892 PT - Journal Article ID - 10.1097/SAP.0b013e3181dba892 [doi] PP - ppublish LG - English DP - 2010 May EZ - 2010/04/17 06:00 DA - 2010/09/02 06:00 DT - 2010/04/17 06:00 YR - 2010 ED - 20100901 RD - 20100421 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20395795 <434. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19929887 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Haddock N AU - Levine J FA - Haddock, Nicholas FA - Levine, Jamie IN - Haddock, Nicholas. The Institute of Reconstructive Plastic Surgery, 550 First Ave, TH169, New York, NY 10016, USA. TI - Breast reconstruction with implants, tissue expanders and AlloDerm: predicting volume and maximizing the skin envelope in skin sparing mastectomies. SO - Breast Journal. 16(1):14-9, 2010 Jan-Feb AS - Breast J. 16(1):14-9, 2010 Jan-Feb NJ - The breast journal VO - 16 IP - 1 PG - 14-9 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implants MH - Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Follow-Up Studies MH - Humans MH - Linear Models MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Organ Size MH - Predictive Value of Tests MH - Probability MH - Prosthesis Design MH - Prosthesis Failure MH - Registries MH - Retrospective Studies MH - Risk Assessment MH - Time Factors MH - Tissue Expansion Devices MH - Treatment Outcome AB - AlloDerm has been used as a tissue supplement in conjunction with the pectoralis major muscle to provide full coverage over an implant in breast reconstruction. While this method of reconstruction has shown promising results there is little known on the relationship of AlloDerm size and potential immediate expansion volume. A retrospective chart review was completed evaluating all tissue expander or primary implant reconstructions using AlloDerm. Data recorded included: The type/size of implant/expander, dimensions of the AlloDerm used, initial fill volume, number of expansions and time period of expansion. Statistical analysis was completed with a linear regression model. AlloDerm was used on 49 patients (72 reconstructions). Thirty-four patients (50 reconstructions) underwent reconstruction with a tissue expander and 15 patients (22 reconstructions) underwent a single stage reconstruction with a permanent implant. The tissue expander volume filled (cc) could be predicted by 5 x surface area of AlloDerm (cm(2)) - 12 (R(2) = 0.62) and 80 x height of AlloDerm (cm) - 15 (R(2) = 0.59). The tissue expanders could be filled to an average of 75% of total size and required three to four injections in the postoperative period to reach full expansion. Obviously, a requirement for maximal implant expansion is an appropriate skin sparing mastectomy. There is a mathematical relationship between fill volume and surface area as well as height of AlloDerm used in breast reconstruction. This analysis provides a guideline for immediate implant expansion to surgeons using AlloDerm in reconstructive breast surgery. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/j.1524-4741.2009.00866.x PT - Comparative Study PT - Journal Article ID - TBJ866 [pii] ID - 10.1111/j.1524-4741.2009.00866.x [doi] PP - ppublish LG - English EP - 20091119 DP - 2010 Jan-Feb EZ - 2009/11/26 06:00 DA - 2010/08/18 06:00 DT - 2009/11/26 06:00 YR - 2010 ED - 20100817 RD - 20101129 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19929887 <435. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20442096 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Buck DW 2nd AU - Heyer K AU - DiBardino D AU - Bethke K AU - Kim JY FA - Buck, Donald W 2nd FA - Heyer, Kamaldeep FA - DiBardino, David FA - Bethke, Kevin FA - Kim, John Y S IN - Buck, Donald W 2nd. Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. TI - Acellular dermis-assisted breast reconstruction with the use of crescentric tissue expansion: a functional cosmetic analysis of 40 consecutive patients. SO - Aesthetic Surgery Journal. 30(2):194-200, 2010 Mar AS - Aesthet. surg. j.. 30(2):194-200, 2010 Mar NJ - Aesthetic surgery journal VO - 30 IP - 2 PG - 194-200 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Adult MH - Aged MH - Aged, 80 and over MH - *Breast Implants MH - Esthetics MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications MH - Retrospective Studies MH - Surveys and Questionnaires MH - *Tissue Expansion/mt [Methods] MH - Treatment Outcome AB - BACKGROUND: Crescentric tissue expanders have the potential to improve postoperative aesthetic results via selective lower pole expansion; however, limited data are available on their efficacy. AB - OBJECTIVES: The authors assess postoperative functional and cosmetic outcomes of acellular dermis-assisted breast reconstruction with crescentric tissue expansion. AB - METHODS: This study is a single-institution, retrospective review of 40 consecutive patients who underwent acellular dermis-assisted breast reconstruction with crescentric tissue expansion. Demographic data, operative details, and procedural outcomes were recorded and assessed. Cosmetic outcomes were assessed using the Breast Evaluation Questionnaire. AB - RESULTS: Fifty-eight breasts representing 36 bilateral and 22 unilateral reconstructions were analyzed. Of these, 45 (78%) underwent tissue expander (TE) to implant exchange. The mean interval between stage 1 and stage 2 was 92 +/- 20 days, with a total follow-up time of 141 +/- 16 days. The average intraoperative expander fill volume was 213.5 mL, with an average final fill of 285 mL (range, 180-740 mL). The average number of expansions was 1.6. Overall, there were five complications (8.6%). Eighty-three percent of patients participated in the breast evaluation questionnaire. Answers to each question were reported using a qualitative five-point scale that ranged from 1 (very dissatisfied) to 5 (very satisfied). For the bilateral reconstructions, the average score in all contexts was 4.5 +/- 0.3, 4.33 +/- 0.5, and 4.36 +/- 0.33 for size, shape, and firmness, respectively. For unilateral reconstructions, the average scores were 4.0 +/- 0.58, 3.93 +/- 0.38, and 4.13 +/- 0.21, respectively. AB - CONCLUSIONS: Crescentric expander-based reconstruction with acellular dermis assistance is well tolerated, especially in smaller breasted women. Functional and cosmetic outcomes were acceptable and comparable to previous reports of traditional expander-based reconstructions. ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1177/1090820X10366547 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 30/2/194 [pii] ID - 10.1177/1090820X10366547 [doi] PP - ppublish LG - English DP - 2010 Mar EZ - 2010/05/06 06:00 DA - 2010/08/14 06:00 DT - 2010/05/06 06:00 YR - 2010 ED - 20100813 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20442096 <436. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20011582 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Grabov-Nardini G AU - Haik J AU - Regev E AU - Winkler E FA - Grabov-Nardini, G FA - Haik, J FA - Regev, E FA - Winkler, E IN - Grabov-Nardini, G. Department of Plastic & Reconstructive Surgery, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel (Affiliated to Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel). ggn207@gmail.com TI - AlloDerm Sling for Correction of Synmastia After Immediate, Tissue Expander, Breast Reconstruction in Thin Women. SO - Eplasty [Electronic Resource]. 9:e54, 2009 Nov 12 AS - Eplasty. 9:e54, 2009 Nov 12 NJ - Eplasty VO - 9 PG - e54 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101316107 IO - Eplasty PM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779996 CP - United States AB - INTRODUCTION: Synmastia is a condition in which the breasts are conjoint and the natural intermammary sulcus is obliterated. It is the rarest type of breast implant malpositioning during breast augmentation; however, it is the most difficult one to correct. AlloDerm is an acellular dermal matrix that is assuming a major role in immediate breast reconstruction in recent years. AB - METHODS: In the past 2 years, we have treated 3 thin women, a total of 6 breasts, for correction of synmastia after bilateral immediate breast reconstruction, using tissue expanders and skin sparing mastectomy. All of them suffered from synmastia, which manifested immediately after the mastectomy and accelerated during tissue expander inflation. We exchanged the expander into silicone implants, and during the same procedure we corrected the synmastia, using an AlloDerm sling. A thick sheet of AlloDerm (Life-Cell Corp, Branchbung, NJ) is used and the AlloDerm sheet is designed into a long narrow sling. Then, the sling is sutured into place. AB - RESULTS: This technique successfully resolved the synmastia. AB - CONCLUSION: The use of an AlloDerm sling to reinforce the capsule and the AlloDerm incorporation into it ensures a sound solution with a low recurrence rate. ES - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC2779996 [pmc] PP - epublish LG - English EP - 20091112 DP - 2009 Nov 12 EZ - 2009/12/17 06:00 DA - 2009/12/17 06:01 DT - 2009/12/17 06:00 YR - 2009 ED - 20100628 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=20011582 <437. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20517083 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Antony AK AU - McCarthy CM AU - Cordeiro PG AU - Mehrara BJ AU - Pusic AL AU - Teo EH AU - Arriaga AF AU - Disa JJ FA - Antony, Anuja K FA - McCarthy, Colleen M FA - Cordeiro, Peter G FA - Mehrara, Babak J FA - Pusic, Andrea L FA - Teo, Esther H FA - Arriaga, Alexander F FA - Disa, Joseph J IN - Antony, Anuja K. Plastic and Reconstructive Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. TI - Acellular human dermis implantation in 153 immediate two-stage tissue expander breast reconstructions: determining the incidence and significant predictors of complications. CM - Comment in: Plast Reconstr Surg. 2011 Jan;127(1):481-2; author reply 482-3; PMID: 21200253 SO - Plastic & Reconstructive Surgery. 125(6):1606-14, 2010 Jun AS - Plast Reconstr Surg. 125(6):1606-14, 2010 Jun NJ - Plastic and reconstructive surgery VO - 125 IP - 6 PG - 1606-14 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Cellulitis/ep [Epidemiology] MH - Cellulitis/pa [Pathology] MH - *Dermis/su [Surgery] MH - Female MH - Humans MH - Incidence MH - Logistic Models MH - *Mammaplasty/mt [Methods] MH - *Mammaplasty/sn [Statistics & Numerical Data] MH - Mastectomy/mt [Methods] MH - Mastectomy/sn [Statistics & Numerical Data] MH - Middle Aged MH - Necrosis MH - *Postoperative Complications/ep [Epidemiology] MH - Postoperative Complications/pa [Pathology] MH - Predictive Value of Tests MH - Retrospective Studies MH - Risk Factors MH - Seroma/ep [Epidemiology] MH - Seroma/pa [Pathology] MH - Surgical Wound Infection/ep [Epidemiology] MH - Young Adult AB - BACKGROUND: Little information exists on the incidence of complications after acellular human dermis implantation in two-stage tissue expander breast reconstruction. The purpose of this study was to evaluate the incidence of postoperative adverse events and identify significant predictors of complications in acellular human dermis tissue expander breast reconstruction. AB - METHODS: This study accrued all patients from January of 2004 through April of 2008 undergoing two-stage immediate tissue expander breast reconstruction using acellular human dermis. A total of 153 expanders were placed. Complications were assessed. Univariate and multivariate logistic regression modeling was performed. Comparison of complication rates using the traditional (non-acellular human dermis) technique from concurrent (2004 to 2008) and consecutive time periods (2001 to 2003) for 2910 and 1170 expanders, respectively, is provided. AB - RESULTS: A total of 153 expanders were implanted in 96 women: 39 unilateral and 57 bilateral. Eleven (7.2 percent) were removed due to infection (n = 5, 3.3 percent), exposure (n = 4, 2.6 percent), or patient preference (n = 2, 1.3 percent). Other complications included cellulitis (3.9 percent), seroma (7.2 percent), hematoma (2.0 percent), mastectomy flap necrosis (4.6 percent), and leak/failed expansion (0.0 percent); 92.8 percent were successfully expanded and exchanged for a permanent implant. Eleven seromas (7.2 percent) were identified; nine underwent aspiration. None of these resulted in infection or reconstructive failure. Univariate analysis revealed age, body mass index, axillary dissection, and postoperative chemotherapy to be associated with reconstructive failure (p < 0.05). Multivariate analysis revealed that age, body mass index, and axillary dissection are independent risk factors for developing complications (p < 0.05). AB - CONCLUSION: Acellular human dermis is a useful adjunct for intraoperative pocket development in immediate tissue expander reconstruction but can result in an increased risk of complications, in particular, seroma and reconstructive failure. RN - 0 (Biocompatible Materials) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181d4fb2a PT - Journal Article ID - 10.1097/PRS.0b013e3181d4fb2a [doi] ID - 00006534-201006000-00004 [pii] PP - ppublish LG - English DP - 2010 Jun EZ - 2010/06/03 06:00 DA - 2010/06/19 06:00 DT - 2010/06/03 06:00 YR - 2010 ED - 20100618 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20517083 <438. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19568065 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Vendemia N AU - Rohde C FA - Vendemia, Nicholas FA - Rohde, Christine IN - Vendemia, Nicholas. Division of Plastic and Reconstructive Surgery, New York-Presbyterian Medical Center, New York, NY 10032, USA. TI - Toxic shock syndrome after prosthetic breast reconstruction with AlloDerm. SO - Plastic & Reconstructive Surgery. 124(1):173e-4e, 2009 Jul AS - Plast Reconstr Surg. 124(1):173e-4e, 2009 Jul NJ - Plastic and reconstructive surgery VO - 124 IP - 1 PG - 173e-4e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Collagen/ae [Adverse Effects] MH - Female MH - Humans MH - *Mammaplasty/ae [Adverse Effects] MH - Middle Aged MH - *Shock, Septic/et [Etiology] MH - *Skin, Artificial/ae [Adverse Effects] MH - *Staphylococcal Infections/et [Etiology] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181a83a19 PT - Case Reports PT - Journal Article ID - 10.1097/PRS.0b013e3181a83a19 [doi] ID - 00006534-200907000-00088 [pii] PP - ppublish LG - English DP - 2009 Jul EZ - 2009/07/02 09:00 DA - 2010/06/04 06:00 DT - 2009/07/02 09:00 YR - 2009 ED - 20100603 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19568065 <439. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19568066 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Buck DW 2nd AU - Heyer K AU - Wayne JD AU - Yeldandi A AU - Kim JY FA - Buck, Donald W 2nd FA - Heyer, Kamaldeep FA - Wayne, Jeffrey D FA - Yeldandi, Anjana FA - Kim, John Y S IN - Buck, Donald W 2nd. Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA. TI - Diagnostic dilemma: acellular dermis mimicking a breast mass after immediate tissue expander breast reconstruction. SO - Plastic & Reconstructive Surgery. 124(1):174e-6e, 2009 Jul AS - Plast Reconstr Surg. 124(1):174e-6e, 2009 Jul NJ - Plastic and reconstructive surgery VO - 124 IP - 1 PG - 174e-6e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Breast MH - *Breast Neoplasms/di [Diagnosis] MH - *Collagen/ae [Adverse Effects] MH - Diagnosis, Differential MH - Female MH - *Foreign Bodies/di [Diagnosis] MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Skin, Artificial/ae [Adverse Effects] MH - *Tissue Expansion RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181a83c69 PT - Case Reports PT - Journal Article ID - 10.1097/PRS.0b013e3181a83c69 [doi] ID - 00006534-200907000-00089 [pii] PP - ppublish LG - English DP - 2009 Jul EZ - 2009/07/02 09:00 DA - 2010/06/04 06:00 DT - 2009/07/02 09:00 YR - 2009 ED - 20100603 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19568066 <440. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19568048 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Stump A AU - Holton LH 3rd AU - Connor J AU - Harper JR AU - Slezak S AU - Silverman RP FA - Stump, Amy FA - Holton, Luther H 3rd FA - Connor, Jerome FA - Harper, John R FA - Slezak, Sheri FA - Silverman, Ronald P IN - Stump, Amy. Division of Plastic Surgery, University of Maryland Medical Center, and LifeCell Corporation, Baltimore, MD 21201, USA. amyshinminato@yahoo.com TI - The use of acellular dermal matrix to prevent capsule formation around implants in a primate model. CM - Comment in: Plast Reconstr Surg. 2010 Nov;126(5):1791-2; author reply 1792-3; PMID: 21042149 SO - Plastic & Reconstructive Surgery. 124(1):82-91, 2009 Jul AS - Plast Reconstr Surg. 124(1):82-91, 2009 Jul NJ - Plastic and reconstructive surgery VO - 124 IP - 1 PG - 82-91 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Animals MH - *Breast Implants/ae [Adverse Effects] MH - Cercopithecus aethiops MH - *Collagen MH - Postoperative Complications/pc [Prevention & Control] MH - *Skin, Artificial AB - BACKGROUND: Implant-based breast reconstruction is a popular option after mastectomy, but capsular contracture may detract from long-term outcomes. The authors have observed that breast implants covered with acellular dermal matrix (AlloDerm) are less likely to develop a capsule in the area where the implant is in direct contact with the acellular matrix. The authors tested this observation experimentally by comparing capsular formation around implants in the presence and absence of AlloDerm in primates. AB - METHODS: Eight smooth-surfaced tissue expanders were implanted into eight African green monkeys. In four experimental animals, a sheet of AlloDerm was draped over the tissue expander so as to cover the implant. Four control animals underwent placement of a tissue expander only. Animals were killed after 10 weeks and specimens underwent histologic and immunohistochemical analysis. AB - RESULTS: Hematoxylin and eosin staining of control specimens revealed the presence of a distinct layer of wavy, parallel arrays of collagen fibers consistent with capsule formation. Immunostaining identified abundant myofibroblasts, a profibrotic cell found in breast capsules. In the AlloDerm-covered specimens, no capsule layer was visible, and specimens stained weakly for myofibroblasts. The difference in myofibroblast staining intensity was statistically significant. AB - CONCLUSIONS: The use of AlloDerm to partially enclose implants effectively prevented formation of a capsule in areas where AlloDerm contacted the implant at 10 weeks. Long-term studies will be required to determine whether this is a durable result that can be reproduced in humans. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181ab112d PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e3181ab112d [doi] ID - 00006534-200907000-00013 [pii] PP - ppublish LG - English DP - 2009 Jul EZ - 2009/07/02 09:00 DA - 2010/06/04 06:00 DT - 2009/07/02 09:00 YR - 2009 ED - 20100603 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19568048 <441. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19944993 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, CA 92354, USA. TI - Use of the acellular dermal matrix in revisionary aesthetic breast surgery. SO - Aesthetic Surgery Journal. 29(6):485-93, 2009 Nov-Dec AS - Aesthet. surg. j.. 29(6):485-93, 2009 Nov-Dec NJ - Aesthetic surgery journal VO - 29 IP - 6 PG - 485-93 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Adult MH - Breast Implantation/ae [Adverse Effects] MH - Breast Implantation/mt [Methods] MH - *Breast Implantation MH - *Breast Implants MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Follow-Up Studies MH - Humans MH - Medical Illustration MH - Postoperative Complications/et [Etiology] MH - *Postoperative Complications/su [Surgery] MH - Reoperation MH - Retrospective Studies MH - Silicone Gels MH - Suture Techniques MH - Treatment Outcome AB - BACKGROUND: Revisionary augmentation and revision of augmentation mastopexy are of considerable interest to plastic surgeons who perform breast surgery because of the procedures' complexity. In these cases, surgeons are faced with either thinned breast tissues resulting from large breast implants with tissue stretch or encapsulation caused by excessive scarring. To our knowledge, there are currently no large-series studies describing the use of acellular dermal matrices (ADM) in cosmetic breast surgery. AB - OBJECTIVE: The authors describe the use of the ADM in revisionary breast surgery to establish the aesthetic breast form. AB - METHODS: A retrospective chart review was conducted of 78 consecutive patients who underwent revisionary breast augmentation and augmentation mastopexies with ADM during a period of just over two years (October 2005 to January 2008). Data collected included patient characteristics, complications, outcomes, and reoperation rates. AB - RESULTS: Seventy-eight procedures were performed with ADM during the two-year period, with a minimum of 12 months of follow-up. There were two complications requiring reoperations for a hematoma and implant malposition, respectively. There were no Baker III or IV capsular contractures at one year postprocedure. AB - CONCLUSIONS: Revisionary augmentation and revision of augmentation mastopexy are commonly performed procedures and they have a significantly higher complication rate than primary procedures. This series shows that the ADM can be used both safely and effectively in revisionary cases, resulting in decreased rates of capsular contracture and implant cushioning/stabilization. RN - 0 (Alloderm) RN - 0 (Silicone Gels) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1016/j.asj.2009.09.007 PT - Journal Article ID - S1090-820X(09)00361-6 [pii] ID - 10.1016/j.asj.2009.09.007 [doi] PP - ppublish PH - 2009/01/26 [received] PH - 2009/02/16 [accepted] LG - English DP - 2009 Nov-Dec EZ - 2009/12/01 06:00 DA - 2010/03/23 06:00 DT - 2009/12/01 06:00 YR - 2009 ED - 20100322 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19944993 <442. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20124833 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chen WF AU - Barounis D AU - Kalimuthu R FA - Chen, Wei F FA - Barounis, David FA - Kalimuthu, Ramasamy IN - Chen, Wei F. Division of Plastic and Reconstructive Surgery, Department of Surgery, and the School of Medicine, University of Illinois at Chicago, Chicago, Ill, USA. weifchen@hotmail.com TI - A novel cost-saving approach to the use of acellular dermal matrix (AlloDerm) in postmastectomy breast and nipple reconstructions. SO - Plastic & Reconstructive Surgery. 125(2):479-81, 2010 Feb AS - Plast Reconstr Surg. 125(2):479-81, 2010 Feb NJ - Plastic and reconstructive surgery VO - 125 IP - 2 PG - 479-81 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Aged, 80 and over MH - *Biocompatible Materials/ec [Economics] MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Breast/su [Surgery] MH - Breast Implants/ec [Economics] MH - Cost Savings MH - Female MH - Humans MH - Insurance, Health MH - *Mammaplasty/ec [Economics] MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Nipples/su [Surgery] MH - Patient Satisfaction MH - Retrospective Studies MH - Tissue Expansion Devices/ec [Economics] RN - 0 (Biocompatible Materials) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181c82da6 PT - Journal Article ID - 10.1097/PRS.0b013e3181c82da6 [doi] ID - 00006534-201002000-00007 [pii] PP - ppublish LG - English DP - 2010 Feb EZ - 2010/02/04 06:00 DA - 2010/03/02 06:00 DT - 2010/02/04 06:00 YR - 2010 ED - 20100301 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20124833 <443. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20124828 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Chun YS AU - Verma K AU - Rosen H AU - Lipsitz S AU - Morris D AU - Kenney P AU - Eriksson E FA - Chun, Yoon S FA - Verma, Kapil FA - Rosen, Heather FA - Lipsitz, Stuart FA - Morris, Donald FA - Kenney, Pardon FA - Eriksson, Elof IN - Chun, Yoon S. Division of Plastic Surgery, Department of Surgery, Harvard Medical School, Brigham and Women's Hospital/Faulkner Hospital, Boston, Mass, USA. ychun@partners.org TI - Implant-based breast reconstruction using acellular dermal matrix and the risk of postoperative complications. CM - Comment in: Plast Reconstr Surg. 2010 Sep;126(3):1121-2; author reply 1122; PMID: 20811255 SO - Plastic & Reconstructive Surgery. 125(2):429-36, 2010 Feb AS - Plast Reconstr Surg. 125(2):429-36, 2010 Feb NJ - Plastic and reconstructive surgery VO - 125 IP - 2 PG - 429-36 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Biocompatible Materials/tu [Therapeutic Use] MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - Comorbidity MH - Female MH - Humans MH - Logistic Models MH - *Mammaplasty/mt [Methods] MH - *Mammaplasty/sn [Statistics & Numerical Data] MH - Mastectomy MH - Middle Aged MH - *Postoperative Complications/ep [Epidemiology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Retrospective Studies MH - Risk Factors MH - Surgical Flaps MH - Surgical Wound Infection/ep [Epidemiology] MH - Surgical Wound Infection/pc [Prevention & Control] MH - Tissue Expansion Devices AB - BACKGROUND: Acellular dermal matrix has been popularized as an adjunct to tissue expander or implant breast reconstruction given its utility in providing additional coverage and support for the inferior pole. This study was performed to assess the risk of postoperative complications associated with the use of acellular dermal matrix-assisted implant-based reconstruction. AB - METHODS: The authors performed a retrospective analysis of consecutive immediate breast reconstructions performed over a 6-year period. A total of 415 implant-based reconstructions were divided into two groups: tissue expander or implant-based reconstruction with or without acellular dermal matrix. Demographic information, comorbidities, oncologic data, adjuvant therapy, and complications were collected for comparison. AB - RESULTS: A total of 283 patients underwent 415 immediate breast reconstructions (151 unilateral and 132 bilateral); 269 reconstructions were performed using tissue expander or implants with acellular dermal matrix, and 146 reconstructions were performed without acellular dermal matrix. The seroma and infection rates were higher in the acellular dermal matrix group (14.1 versus 2.7 percent, p = 0.0003, for seroma; 8.9 versus 2.1 percent, p = 0.0328, for infection). Multiple logistic regression analysis showed that acellular dermal matrix and body mass index were statistically significant risk factors for developing seroma and infection. The use of acellular dermal matrix increased the odds of seroma by 4.24 times (p = 0.018) and infection by 5.37 times (p = 0.006). AB - CONCLUSIONS: Acellular dermal matrix has enhanced implant-based reconstruction and remains useful in immediate prosthetic breast reconstruction. It is associated, however, with higher rates of postoperative seroma and infection. Careful patient selection, choice of tissue expander/implant volume, and postoperative management are warranted to optimize overall reconstructive outcome. RN - 0 (Biocompatible Materials) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181c82d90 PT - Journal Article ID - 10.1097/PRS.0b013e3181c82d90 [doi] ID - 00006534-201002000-00001 [pii] PP - ppublish LG - English DP - 2010 Feb EZ - 2010/02/04 06:00 DA - 2010/03/02 06:00 DT - 2010/02/04 06:00 YR - 2010 ED - 20100301 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20124828 <444. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20124811 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Heyer K AU - Buck DW 2nd AU - Kato C AU - Khan SA AU - Alam M AU - Kim JY FA - Heyer, Kamaldeep FA - Buck, Donald W 2nd FA - Kato, Caroline FA - Khan, Seema A FA - Alam, Murad FA - Kim, John Y S IN - Heyer, Kamaldeep. Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA. TI - Reversed acellular dermis: failure of graft incorporation in primary tissue expander breast reconstruction resulting in recurrent breast cellulitis. SO - Plastic & Reconstructive Surgery. 125(2):66e-68e, 2010 Feb AS - Plast Reconstr Surg. 125(2):66e-68e, 2010 Feb NJ - Plastic and reconstructive surgery VO - 125 IP - 2 PG - 66e-68e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Breast Diseases/et [Etiology] MH - Breast Implants MH - *Breast Neoplasms/su [Surgery] MH - *Cellulitis/et [Etiology] MH - Female MH - *Graft Rejection MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - Postoperative Complications/et [Etiology] MH - Recurrence MH - *Skin Transplantation MH - Skin, Artificial MH - *Tissue Expansion Devices ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181c7264e PT - Case Reports PT - Journal Article ID - 10.1097/PRS.0b013e3181c7264e [doi] ID - 00006534-201002000-00069 [pii] PP - ppublish LG - English DP - 2010 Feb EZ - 2010/02/04 06:00 DA - 2010/03/02 06:00 DT - 2010/02/04 06:00 YR - 2010 ED - 20100301 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20124811 <445. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20037339 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Miura T AU - Takeuchi I AU - Kikuoka S AU - Miura T FA - Miura, Tsuyoshi FA - Takeuchi, Ikuya FA - Kikuoka, Shuichi FA - Miura, Takako IN - Miura, Tsuyoshi. Department of Surgery, Miura Hospital. TI - [Intra-arterial infusion chemotherapy for advanced breast cancer--5 cases of marked response]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 36(12):2108-10, 2009 Nov AS - Gan To Kagaku Ryoho. 36(12):2108-10, 2009 Nov NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 36 IP - 12 PG - 2108-10 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Breast Neoplasms/dt [Drug Therapy] MH - *Carcinoma, Ductal, Breast/dt [Drug Therapy] MH - Female MH - Humans MH - Infusions, Intra-Arterial MH - Mastectomy, Radical AB - In order to obtain less severe toxic reactions, while attaining maximal therapeutic effects, CPA, 5-FU and ADM or EPI have been administered through the catheter inserted into the internal thoracic artery with the IVR technique and the implantable infusion port system. Of the 181 patients with the unresectable or recurrent breast cancers attempted with intra- arterial infusion chemotherapy for the past 19 years, more than half of the patients showed a good response to this modality of the chemotherapy. In 4 out of the 5 patients with unresectable breast cancer, radical mastectomy became feasible following the marked response with the intra-arterial infusion chemotherapy. However, a distant metastasis proved to be a limiting factor for improvement of survival. IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2009 Nov EZ - 2009/12/29 06:00 DA - 2010/02/19 06:00 DT - 2009/12/29 06:00 YR - 2009 ED - 20100218 RD - 20091228 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20037339 <446. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 20009806 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Colwell AS AU - Breuing KH FA - Colwell, Amy S FA - Breuing, Karl H IN - Colwell, Amy S. Division of Plastic Surgery, Massachusetts General Hospital, Boston, Mass 02115, USA. TI - Primary nipple reconstruction with AlloDerm: is a dermal flap always necessary?. SO - Plastic & Reconstructive Surgery. 124(5):260e-2e, 2009 Nov AS - Plast Reconstr Surg. 124(5):260e-2e, 2009 Nov NJ - Plastic and reconstructive surgery VO - 124 IP - 5 PG - 260e-2e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implantation MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mastectomy, Modified Radical MH - *Nipples MH - Skin, Artificial MH - *Surgical Flaps MH - Sutures RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181b98e42 PT - Journal Article ID - 10.1097/PRS.0b013e3181b98e42 [doi] ID - 00006534-200911000-00065 [pii] PP - ppublish LG - English DP - 2009 Nov EZ - 2009/12/17 06:00 DA - 2010/01/12 06:00 DT - 2009/12/17 06:00 YR - 2009 ED - 20100111 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=20009806 <447. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19952629 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. drnahabedian@aol.com TI - AlloDerm performance in the setting of prosthetic breast surgery, infection, and irradiation. CM - Comment in: Plast Reconstr Surg. 2010 Sep;126(3):1120; author reply 1120-1; PMID: 20811254 SO - Plastic & Reconstructive Surgery. 124(6):1743-53, 2009 Dec AS - Plast Reconstr Surg. 124(6):1743-53, 2009 Dec NJ - Plastic and reconstructive surgery VO - 124 IP - 6 PG - 1743-53 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adolescent MH - Adult MH - Aged MH - *Breast/re [Radiation Effects] MH - Breast Implantation/ae [Adverse Effects] MH - *Breast Implantation/mt [Methods] MH - *Breast Implants/ae [Adverse Effects] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - *Collagen/tu [Therapeutic Use] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Graft Rejection MH - Graft Survival MH - Humans MH - Incidence MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Reoperation MH - Retrospective Studies MH - Risk Assessment MH - Surgical Wound Infection/di [Diagnosis] MH - *Surgical Wound Infection/ep [Epidemiology] MH - Tissue Expansion Devices/ae [Adverse Effects] MH - Treatment Outcome MH - Wound Healing/ph [Physiology] MH - Young Adult AB - BACKGROUND: The performance of AlloDerm (LifeCell Corp., Branchburg, N.J.) in the setting of prosthetic breast reconstruction, infection, and radiation therapy has not been well documented. The purpose of this study was to review the author's experience with AlloDerm-assisted prosthetic breast surgery and determine the tolerance in the setting of infection and irradiation. AB - METHODS: A total of 361 women and 476 breasts underwent reconstruction or revision with prosthetic devices. Of these, 76 women and 100 breasts underwent reconstruction using AlloDerm assistance. AB - RESULTS: The incidence of postoperative infection was 5.85 percent (22 of 376) when prosthetic devices were used without AlloDerm and 5 percent (five of 100) when prosthetic devices were used with AlloDerm. Radiation therapy was a factor in 23 of 100 breasts reconstructed with AlloDerm. Adherence of AlloDerm was noted in 100 percent (23 of 23) and infection was noted in 8.7 percent (two of 23). The timing of irradiation (before or after AlloDerm insertion) did not affect the adherence or the infection rate. The overall incidence of seroma was 5 percent, the incidence of skin necrosis was 3 percent, and the incidence of incisional dehiscence was 4 percent. AB - CONCLUSIONS: This study demonstrates that prosthetic breast surgery using AlloDerm is safe and well-tolerated. AlloDerm viability has been demonstrated in the setting of infection and radiation therapy. The risk of prosthetic breast infection in the setting with AlloDerm is no different from in the setting without AlloDerm. Local complications such as dehiscence, skin necrosis, and seroma formation can occur in accordance with radiotherapy. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181bf8087 PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e3181bf8087 [doi] ID - 00006534-200912000-00003 [pii] PP - ppublish LG - English DP - 2009 Dec EZ - 2009/12/03 06:00 DA - 2010/01/12 06:00 DT - 2009/12/03 06:00 YR - 2009 ED - 20100111 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19952629 <448. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19952628 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL FA - Spear, Scott L IN - Spear, Scott L. Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. spears@gunet.georgetown.edu TI - Discussion. Acellular dermis-assisted prosthetic breast reconstruction versus complete submuscular coverage: a head-to-head comparison of outcomes. CM - Comment on: Plast Reconstr Surg. 2009 Dec;124(6):1735-40; PMID: 19952627 SO - Plastic & Reconstructive Surgery. 124(6):1741-2, 2009 Dec AS - Plast Reconstr Surg. 124(6):1741-2, 2009 Dec NJ - Plastic and reconstructive surgery VO - 124 IP - 6 PG - 1741-2 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Breast Implants MH - Esthetics MH - Female MH - Graft Rejection MH - Graft Survival MH - Humans MH - *Mammaplasty/mt [Methods] MH - Pectoralis Muscles/tr [Transplantation] MH - Prognosis MH - Skin Transplantation/mt [Methods] MH - *Skin, Artificial MH - *Surgical Flaps MH - Wound Healing/ph [Physiology] ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181bf7f3a PT - Comment PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e3181bf7f3a [doi] ID - 00006534-200912000-00002 [pii] PP - ppublish LG - English DP - 2009 Dec EZ - 2009/12/03 06:00 DA - 2010/01/12 06:00 DT - 2009/12/03 06:00 YR - 2009 ED - 20100111 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19952628 <449. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19952627 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sbitany H AU - Sandeen SN AU - Amalfi AN AU - Davenport MS AU - Langstein HN FA - Sbitany, Hani FA - Sandeen, Sven N FA - Amalfi, Ashley N FA - Davenport, Mark S FA - Langstein, Howard N IN - Sbitany, Hani. Division of Plastic and Reconstructive Surgery, University of Rochester, NY, USA. TI - Acellular dermis-assisted prosthetic breast reconstruction versus complete submuscular coverage: a head-to-head comparison of outcomes. CM - Comment in: Plast Reconstr Surg. 2010 Aug;126(2):672-3; author reply 673-4; PMID: 20679855 CM - Comment in: Plast Reconstr Surg. 2009 Dec;124(6):1741-2; PMID: 19952628 SO - Plastic & Reconstructive Surgery. 124(6):1735-40, 2009 Dec AS - Plast Reconstr Surg. 124(6):1735-40, 2009 Dec NJ - Plastic and reconstructive surgery VO - 124 IP - 6 PG - 1735-40 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast Implants MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Cohort Studies MH - Esthetics MH - Female MH - Graft Rejection MH - Graft Survival MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Middle Aged MH - Pectoralis Muscles/tr [Transplantation] MH - Probability MH - Retrospective Studies MH - Risk Assessment MH - Skin Transplantation/mt [Methods] MH - *Skin, Artificial MH - *Surgical Flaps MH - Treatment Outcome MH - Wound Healing/ph [Physiology] AB - BACKGROUND: Complete submuscular tissue expander coverage affords the best protection against implant exposure but restricts lower pole expansion. Techniques using acellular dermis as a pectoralis muscle extension can allow for more rapid fill of the expander and better control of the inframammary fold. This study compares both techniques with regard to relevant outcomes. AB - METHODS: Results of 100 consecutive breast expander reconstructions performed by two surgeons between 2004 and 2007 were retrospectively reviewed. Patient demographics, expander coverage type, adjuvant treatment, length and characteristics of the expansion, and incidence and types of complications were analyzed. AB - RESULTS: One hundred women underwent breast reconstruction with 172 expanders, in 50 using complete submuscular placement and in 50 using partial subpectoral placement with acellular dermis. The patient groups were similar in terms of demographic data. Mean number of fills to complete reconstruction was 4.31 in the submuscular group and 1.72 in the acellular dermis group (p = 0.0001). Mean intraoperative fill volume was 130 cc in the submuscular group, compared with 412 cc per expander in the acellular dermis group (p = 0.0001). Fisher's exact test demonstrated no significant difference in total complication rate between the two groups (14 percent versus 18 percent; p = 0.79). AB - CONCLUSIONS: Acellular dermis allowed for a greater initial fill of saline. This potentially improves cosmetic outcome, as it better capitalizes on preserved mastectomy skin for reconstruction. The authors conclude that acellular dermis-assisted implant breast reconstruction has a safety profile no worse than that of complete submuscular coverage but offers the benefit of fewer expansions and the potential for more predictable secondary revisions. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181bf803d PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e3181bf803d [doi] ID - 00006534-200912000-00001 [pii] PP - ppublish LG - English DP - 2009 Dec EZ - 2009/12/03 06:00 DA - 2010/01/12 06:00 DT - 2009/12/03 06:00 YR - 2009 ED - 20100111 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19952627 <450. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19644305 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mangano A AU - Albertin A AU - LaColla L FA - Mangano, Alberto FA - Albertin, Andrea FA - LaColla, Luca TI - Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: a prospective, randomized intervention study. "tips and tricks" to improve statistical analysis and significance of results. CM - Comment on: Plast Reconstr Surg. 2008 Jul;122(1):10-8; PMID: 18594354 SO - Plastic & Reconstructive Surgery. 124(2):669, 2009 Aug AS - Plast Reconstr Surg. 124(2):669, 2009 Aug NJ - Plastic and reconstructive surgery VO - 124 IP - 2 PG - 669 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Cyanoacrylates/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty MH - Prospective Studies MH - Research Design MH - Statistics as Topic MH - *Tissue Adhesives/ad [Administration & Dosage] RN - 0 (Cyanoacrylates) RN - 0 (Tissue Adhesives) RN - 6C655P1XVG (octyl 2-cyanoacrylate) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181adde55 PT - Letter PT - Comment ID - 10.1097/PRS.0b013e3181adde55 [doi] ID - 00006534-200908000-00061 [pii] PP - ppublish LG - English DP - 2009 Aug EZ - 2009/08/01 09:00 DA - 2009/09/23 06:00 DT - 2009/08/01 09:00 YR - 2009 ED - 20090922 RD - 20161125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19644305 <451. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19644253 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Namnoum JD FA - Namnoum, James D IN - Namnoum, James D. Atlanta Plastic Surgery, Atlanta, Ga 30342, USA. jdnamnoum@atlplastic.com TI - Expander/implant reconstruction with AlloDerm: recent experience. SO - Plastic & Reconstructive Surgery. 124(2):387-94, 2009 Aug AS - Plast Reconstr Surg. 124(2):387-94, 2009 Aug NJ - Plastic and reconstructive surgery VO - 124 IP - 2 PG - 387-94 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implantation/mt [Methods] MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Pectoralis Muscles/su [Surgery] MH - *Skin, Artificial MH - Suture Techniques MH - *Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices AB - BACKGROUND: Expander/implant reconstruction with acellular dermal matrix (AlloDerm) has become an increasingly popular technique. Potential advantages include lengthening of the pectoralis major muscle, preventing "window-shading" after muscle release; precise control of the inframammary fold and lateral breast border; and complete coverage of the device without resorting to additional muscle or fascial elevation. AB - METHODS: Patients undergoing immediate breast reconstruction with tissue expanders underwent acellular dermal matrix augmentation of the pectoralis major muscle. After inferior pectoralis muscle release and creation of a subpectoral pocket, the acellular dermal matrix was draped out to length and sutured to the inframammary fold. An integral port, low-height tissue expander was placed into the pocket and the acellular dermal matrix was sewn to the cut edge of the muscle inferiorly. Subsequent placement of either a smooth-walled silicone gel implant or anatomically shaped cohesive gel device was performed secondarily. AB - RESULTS: Twenty consecutive patients (29 breasts) undergoing immediate breast reconstruction with tissue expanders had acellular dermal matrix augmentation of the pectoralis major muscle. Follow-up averaged 21 months (range, 3 to 32 months). Infection occurred in one of 29 breasts (3.4 percent). One patient had a small area of suture line necrosis requiring revision. AB - CONCLUSIONS: Acellular dermal matrix augmentation of the pectoralis major muscle in the setting of prosthetic breast reconstruction improves the soft-tissue drapery around devices without resorting to additional muscle or fascial flaps. Total device coverage and precise control of the pocket dimensions permit more predictably superior results in these patients. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181aee95b PT - Journal Article ID - 10.1097/PRS.0b013e3181aee95b [doi] ID - 00006534-200908000-00008 [pii] PP - ppublish LG - English DP - 2009 Aug EZ - 2009/08/01 09:00 DA - 2009/09/23 06:00 DT - 2009/08/01 09:00 YR - 2009 ED - 20090922 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19644253 <452. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19309648 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Centeno RF FA - Centeno, Robert F IN - Centeno, Robert F. St. Croix Plastic Surgery and MediSpa, St. Croix, VI, USA. rfcenteno@gmail.com TI - Surgisis acellular collagen matrix in aesthetic and reconstructive plastic surgery soft tissue applications. SO - Clinics in Plastic Surgery. 36(2):229-40, vii, 2009 Apr AS - Clin Plast Surg. 36(2):229-40, vii, 2009 Apr NJ - Clinics in plastic surgery VO - 36 IP - 2 PG - 229-40, vii PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Breast/su [Surgery] MH - *Cell Transplantation/mt [Methods] MH - Coated Materials, Biocompatible MH - *Collagen/me [Metabolism] MH - *Extracellular Matrix/tr [Transplantation] MH - Female MH - Humans MH - Mammaplasty MH - Middle Aged MH - *Reconstructive Surgical Procedures/mt [Methods] MH - *Skin/me [Metabolism] MH - Tissue Extracts/tu [Therapeutic Use] MH - Transplantation, Heterologous AB - Tissue engineering in aesthetic and reconstructive plastic surgery remains an elusive goal. The advent of Surgisis extracellular collagen matrix and its performance characteristics suggest that the use of a bioengineered tissue substitute can meet some of our reconstructive requirements. Incorporation and replacement by host tissue with minimal allergic or immune response seems to be achievable today. The ability to engineer the device, the ready availability of substrate, and its cost effectiveness support the use of Surgisis in aesthetic and reconstructive plastic surgery applications. Future product innovations and engineering seem promising. The permanent role of Surgisis in aesthetic and reconstructive plastic surgery will be determined by its documented long-term performance. RN - 0 (Coated Materials, Biocompatible) RN - 0 (Tissue Extracts) RN - 9007-34-5 (Collagen) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2008.12.004 PT - Case Reports PT - Journal Article ID - S0094-1298(08)00147-8 [pii] ID - 10.1016/j.cps.2008.12.004 [doi] PP - ppublish LG - English DP - 2009 Apr EZ - 2009/03/25 09:00 DA - 2009/07/30 09:00 DT - 2009/03/25 09:00 YR - 2009 ED - 20090729 RD - 20090324 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19309648 <453. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19483545 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Newman MI AU - Samson MC AU - Berho M FA - Newman, Martin I FA - Samson, Michel C FA - Berho, Mariana IN - Newman, Martin I. Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Fla 33331, USA. ewmanm@ccf.org TI - AlloDerm in breast reconstruction: 2 years later. SO - Plastic & Reconstructive Surgery. 123(6):205e-6e, 2009 Jun AS - Plast Reconstr Surg. 123(6):205e-6e, 2009 Jun NJ - Plastic and reconstructive surgery VO - 123 IP - 6 PG - 205e-6e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Treatment Outcome RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181a3f595 PT - Journal Article ID - 10.1097/PRS.0b013e3181a3f595 [doi] ID - 00006534-200906000-00067 [pii] PP - ppublish LG - English DP - 2009 Jun EZ - 2009/06/02 09:00 DA - 2009/07/01 09:00 DT - 2009/06/02 09:00 YR - 2009 ED - 20090630 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19483545 <454. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19010755 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ramsden AJ AU - Allen V AU - O'Donoghue JM FA - Ramsden, A J FA - Allen, V FA - O'Donoghue, J M TI - Anterior rectus sheath repair with porcine collagen (Permacol) in patients undergoing breast reconstruction with free abdominal flaps. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 62(6):e170-1, 2009 Jun AS - J Plast Reconstr Aesthet Surg. 62(6):e170-1, 2009 Jun NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 62 IP - 6 PG - e170-1 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Biocompatible Materials MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Hernia, Abdominal/pc [Prevention & Control] MH - Humans MH - *Mammaplasty/mt [Methods] MH - Polypropylenes/tu [Therapeutic Use] MH - Retrospective Studies MH - *Surgical Flaps RN - 0 (Biocompatible Materials) RN - 0 (Permacol) RN - 0 (Polypropylenes) RN - 9007-34-5 (Collagen) ES - 1878-0539 IL - 1748-6815 DO - https://dx.doi.org/10.1016/j.bjps.2008.08.072 PT - Comparative Study PT - Evaluation Studies PT - Letter ID - S1748-6815(08)01004-8 [pii] ID - 10.1016/j.bjps.2008.08.072 [doi] PP - ppublish PH - 2008/07/10 [received] PH - 2008/08/10 [accepted] LG - English EP - 20081117 DP - 2009 Jun EZ - 2008/11/18 09:00 DA - 2009/06/30 09:00 DT - 2008/11/18 09:00 YR - 2009 ED - 20090629 RD - 20090525 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19010755 <455. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19387155 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Derderian CA AU - Karp NS AU - Choi M FA - Derderian, Christopher A FA - Karp, Nolan S FA - Choi, Mihye IN - Derderian, Christopher A. Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, NY, USA. TI - Wise-pattern breast reconstruction: modification using AlloDerm and a vascularized dermal-subcutaneous pedicle. SO - Annals of Plastic Surgery. 62(5):528-32, 2009 May AS - Ann Plast Surg. 62(5):528-32, 2009 May NJ - Annals of plastic surgery VO - 62 IP - 5 PG - 528-32 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Breast/ah [Anatomy & Histology] MH - *Breast/su [Surgery] MH - Breast Implantation/mt [Methods] MH - *Collagen/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - Organ Size MH - Retrospective Studies MH - Skin, Artificial AB - Immediate implant-based breast mound reconstruction offers many advantages over staged implant reconstruction techniques. For large volume breast reconstruction, a Wise-pattern skin resection may provide very good aesthetic results; however, the submuscular implant pocket is inadequate to cover the inferior pole of the breast. In this patient population, the risk of implant exposure from T-point breakdown is significant. We present our technique of Wise-pattern breast reconstruction using AlloDerm (LifeCell, Branchburg, NJ) and a vascularized dermal-subcutaneous pedicle (DSP) to augment the volume and quality of immediate breast implant coverage, particularly in the area of the T-point suture lines. We reviewed a series of 20 consecutive patients with large breasts who were treated with an immediate implant reconstruction of greater than 400 mL volume using the Wise-pattern with DSP. Preoperative and postoperative 3-dimensional surface scan studies were performed to evaluate breast symmetry. The average volume of breast reconstruction in this study group was 458 mL. T-point breakdown occurred in 5 patients (25%). These patients were treated with local wound care and healed with an excellent aesthetic result. None of these patients required implant removal, implant exchange, or operative debridement. Pre- and postoperative 3-dimensional surface scan analysis of these patients demonstrated comparable differences between the affected and unaffected sides in women undergoing immediate breast implant reconstruction when compared with a matched group of patients undergoing 2-stage breast reconstruction with tissue expanders. Wise-pattern skin-reducing mastectomy is an excellent strategy to provide an aesthetically pleasing, immediate implant breast reconstruction. This technique provides breast symmetry that is at least comparable to that of tissue expander-based, staged implant reconstructions. The reliability of the Wise-pattern technique is significantly improved with the addition of AlloDerm to the muscular pocket and a vascularized DSP to preserve the integrity of the reconstruction in the presence of T-point breakdown. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e3181a0cfee PT - Journal Article ID - 10.1097/SAP.0b013e3181a0cfee [doi] ID - 00000637-200905000-00017 [pii] PP - ppublish LG - English DP - 2009 May EZ - 2009/04/24 09:00 DA - 2009/06/23 09:00 DT - 2009/04/24 09:00 YR - 2009 ED - 20090622 RD - 20090423 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19387155 <456. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19319043 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Komorowska-Timek E AU - Oberg KC AU - Timek TA AU - Gridley DS AU - Miles DA FA - Komorowska-Timek, Ewa FA - Oberg, Kerby C FA - Timek, Tomasz A FA - Gridley, Daila S FA - Miles, Duncan A G IN - Komorowska-Timek, Ewa. Division of Plastic and Reconstructive Surgery, Loma Linda University and Loma Linda University Medical Center, Loma Linda, Calif. 92345, USA. etimek@sbcglobal.net TI - The effect of AlloDerm envelopes on periprosthetic capsule formation with and without radiation. CM - Comment in: Plast Reconstr Surg. 2009 Oct;124(4):1368-9; author reply 1369-70; PMID: 19935334 SO - Plastic & Reconstructive Surgery. 123(3):807-16, 2009 Mar AS - Plast Reconstr Surg. 123(3):807-16, 2009 Mar NJ - Plastic and reconstructive surgery VO - 123 IP - 3 PG - 807-16 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Animals MH - *Breast Implants MH - *Collagen MH - Postoperative Complications/pa [Pathology] MH - *Postoperative Complications/pc [Prevention & Control] MH - Radiation Injuries, Experimental/pa [Pathology] MH - *Radiation Injuries, Experimental/pc [Prevention & Control] MH - Rats MH - Rats, Sprague-Dawley MH - *Skin, Artificial AB - BACKGROUND: The pathobiology of radiation-induced periprosthetic capsular formation and factors that may ameliorate its development have not been fully elucidated. The authors hypothesized that AlloDerm would diminish radiation-induced capsular formation. AB - METHODS: Two 5-ml implants were placed submuscularly in the backs of 41 rats. The right implant was wrapped with AlloDerm and the left remained bare. After 48 hours, 20 animals underwent irradiation to each implant, and 21 animals underwent no further treatment and served as controls. After 3 and 12 weeks, the capsules were harvested and submitted for tensile strength and histologic examination. Intraprosthetic pressures were measured in each implant at the time of surgery and when the animals were killed. AB - RESULTS: The intraprosthetic pressure decrease was uniform among all groups at 3 and 12 weeks. Between 3 and 12 weeks, capsular tensile strength increased in nonirradiated bare implants. There was considerable invasion of nonirradiated AlloDerm by inflammatory infiltrates at 3 weeks, and AlloDerm thickness decreased over time. Cellular invasion of AlloDerm was decreased with irradiation at both time points. Capsular tensile strength and thickness of the irradiated bare and AlloDerm capsules did not change between 3 and 12 weeks. Radiation increased inflammation of bare capsules at 12 weeks, but it was significantly reduced in irradiated AlloDerm capsules. The majority of irradiated bare capsules developed pseudoepithelium, whereas AlloDerm protected capsules from this transformation. AB - CONCLUSION: AlloDerm decreases radiation-related inflammation and delays or diminishes pseudoepithelium formation and thus may slow progression of capsular formation, fibrosis, and contraction. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318199eef3 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e318199eef3 [doi] ID - 00006534-200903000-00005 [pii] PP - ppublish LG - English DP - 2009 Mar EZ - 2009/03/26 09:00 DA - 2009/05/06 09:00 DT - 2009/03/26 09:00 YR - 2009 ED - 20090505 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19319043 <457. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19319039 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Boehmler JH 4th AU - Butler CE AU - Ensor J AU - Kronowitz SJ FA - Boehmler, James H 4th FA - Butler, Charles E FA - Ensor, Joseph FA - Kronowitz, Steven J IN - Boehmler, James H 4th. Department of Plastic Surgery and the Division of Quantitative Sciences, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. TI - Outcomes of various techniques of abdominal fascia closure after TRAM flap breast reconstruction. SO - Plastic & Reconstructive Surgery. 123(3):773-81, 2009 Mar AS - Plast Reconstr Surg. 123(3):773-81, 2009 Mar NJ - Plastic and reconstructive surgery VO - 123 IP - 3 PG - 773-81 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Fasciotomy MH - Female MH - Humans MH - Mammaplasty/mt [Methods] MH - *Mammaplasty MH - Middle Aged MH - Postoperative Complications/ep [Epidemiology] MH - *Rectus Abdominis/su [Surgery] MH - *Skin Transplantation MH - *Surgical Flaps MH - *Surgical Mesh MH - Treatment Outcome AB - BACKGROUND: There is no consensus regarding the optimal technique for closure of the abdominal fascia after transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction. The authors reviewed outcomes with various techniques to identify the optimal one. AB - METHODS: The authors reviewed the charts of 81 consecutive patients who underwent TRAM flap breast reconstruction at their institution from 2002 to 2005. Various amounts of anterior rectus sheath fascia were harvested with the TRAM flap. Patients were divided into five groups based on fascia closure technique: (1) human acellular dermal matrix bridging inlay graft, (2) human acellular dermal matrix bridging inlay graft with primary closure of overlying anterior rectus sheath, (3) polypropylene mesh inlay graft, (4) polypropylene mesh inlay graft with primary closure, and (5) primary closure. For comparative analysis, three additional groups were created: all human acellular dermal matrix bridging inlay graft (groups 1 and 2), all mesh (groups 3 and 4), and all inlay (groups 1 and 3). Rates of donor-site complications were compared between groups. AB - RESULTS: Rates of abdominal bulge formation were as follows: overall, 14.8 percent; human acellular dermal matrix bridging inlay graft alone, 31 percent; human acellular dermal matrix bridging inlay graft plus primary closure, 20 percent; mesh alone, 10 percent; mesh plus primary closure, 5 percent; and primary closure alone, 5 percent. Rates of any complication (including bulge) were as follows: overall, 23.5 percent; human acellular dermal matrix bridging inlay graft alone, 42 percent; human acellular dermal matrix plus primary closure, 20 percent; mesh alone, 30 percent; mesh plus primary closure, 10 percent; and primary closure alone, 5 percent. Time to bulge formation was longer for all human acellular dermal matrix versus all mesh (p = 0.021. Time to any complication was longer for all inlay versus primary closure alone (p = 0.048), human acellular dermal matrix alone versus primary closure alone (p = 0.041). AB - CONCLUSIONS: For abdominal fascia repair after TRAM flap breast reconstruction, primary closure, when feasible, is preferable to an inlay graft; polypropylene mesh is preferable to human acellular dermal matrix if an inlay graft is required; adding primary closure to a mesh or human acellular dermal matrix inlay graft reduces bulge formation and other complications; and bulge occurs later with human acellular dermal matrix than with synthetic mesh. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318199ef4f PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e318199ef4f [doi] ID - 00006534-200903000-00001 [pii] PP - ppublish LG - English DP - 2009 Mar EZ - 2009/03/26 09:00 DA - 2009/05/06 09:00 DT - 2009/03/26 09:00 YR - 2009 ED - 20090505 RD - 20161125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19319039 <458. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19233000 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mofid MM AU - Singh NK FA - Mofid, M Mark FA - Singh, Navin K IN - Mofid, M Mark. Department of Surgery, Division of Plastic Surgery, University of California-San Diego School of Medicine, San Diego, CA, USA. drmofid@mofidplasticsurgery.com TI - Pocket conversion made easy: a simple technique using alloderm to convert subglandular breast implants to the dual-plane position. SO - Aesthetic Surgery Journal. 29(1):12-8, 2009 Jan-Feb AS - Aesthet. surg. j.. 29(1):12-8, 2009 Jan-Feb NJ - Aesthetic surgery journal VO - 29 IP - 1 PG - 12-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J SB - Index Medicus CP - England MH - Adult MH - *Biocompatible Materials/tu [Therapeutic Use] MH - *Breast Implants MH - Case-Control Studies MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Pectoralis Muscles/su [Surgery] MH - Postoperative Complications/pc [Prevention & Control] MH - Reoperation MH - Treatment Outcome AB - BACKGROUND: The advantages of dual-plane, partially submuscular breast implants are well documented. Standard conversion techniques to dual-plane positioning use marionette sutures and internal capsulorrhaphy sutures from the lower edge of the pectoralis major muscle to the anterior capsule or breast fascia within the subglandular plane. These techniques are limited by high rates of postoperative implant malposition and technical limitations that make combined mastopexy procedures difficult to perform. AB - OBJECTIVE: We describe a simple technique familiar to most plastic surgeons accustomed to placing tissue expanders for use in breast reconstruction using Alloderm (LifeCell Corp., Branchburg, NJ) as a sling beneath the pectoralis major muscle to the chest wall. AB - METHODS: We studied 25 women who underwent breast augmentation revision from the subglandular to the dual-plane position by performing a 9-year retrospective review from 1999 to 2007 of 2 surgeons' experience. We identified 10 women for whom Alloderm, sutured from the lower edge of the pectoralis major muscle to the chest wall, was used to create a composite pectoralis-Alloderm pocket for partial submuscular transfer of implants and 15 case controls who underwent pocket conversion using standard capsulorrhaphy and marionette suture techniques. AB - RESULTS: The principal outcome variable of at least 1 complication was 73.3% without Alloderm, resulting in a 40% need for revision surgery, versus 0% with Alloderm (Fisher exact test; P < .05). AB - CONCLUSIONS: The standard techniques available for conversion of subglandular breast implants to the dual-plane position using capsulorrhaphy and marionette sutures are limited by a high complication rate for the reliable positioning into a stable dual-plane pocket during implant exchange. A commonly used technique in reconstructive breast surgery using Alloderm is shown to reliably convert subglandular implants to the dual-plane position. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1016/j.asj.2008.12.005 PT - Journal Article ID - S1090-820X(08)00370-1 [pii] ID - 10.1016/j.asj.2008.12.005 [doi] PP - ppublish PH - 2008/09/10 [accepted] LG - English DP - 2009 Jan-Feb EZ - 2009/02/24 09:00 DA - 2009/04/10 09:00 DT - 2009/02/24 09:00 YR - 2009 ED - 20090409 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19233000 <459. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19055971 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Maxwell GP AU - Gabriel A FA - Maxwell, G Patrick FA - Gabriel, Allen IN - Maxwell, G Patrick. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA. gabrielallen@yahoo.com TI - Possible future development of implants and breast augmentation. SO - Clinics in Plastic Surgery. 36(1):167-72, viii, 2009 Jan AS - Clin Plast Surg. 36(1):167-72, viii, 2009 Jan NJ - Clinics in plastic surgery VO - 36 IP - 1 PG - 167-72, viii PI - Journal available in: Print PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg SB - Index Medicus CP - United States MH - Adipose Tissue/tr [Transplantation] MH - Biocompatible Materials MH - *Breast Implantation/td [Trends] MH - *Breast Implants/td [Trends] MH - Equipment Design MH - Female MH - Forecasting MH - Humans MH - Silicone Gels MH - Tissue Engineering AB - Since the introduction of the silicone gel prosthesis in 1962, breast augmentation has become one of the most frequently performed operations in plastic surgery. As we strive for perfect results, it is important to continue to gather and review data evaluating innovative techniques and devices. Now we even have more options available for breast augmentation, whether we use them in combination or alone. By combining all of the available options (acellular dermal matrix products, silicone implant, fat grafting), we have been able to create "bioengineered breasts" with high patient and surgeon satisfaction. As always in plastic surgery, our concern is with safety; as newer technology and products are introduced to us, patient education, consent, and follow-up remain important. RN - 0 (Biocompatible Materials) RN - 0 (Silicone Gels) ES - 1558-0504 IL - 0094-1298 DO - https://dx.doi.org/10.1016/j.cps.2008.08.005 PT - Journal Article ID - S0094-1298(08)00090-4 [pii] ID - 10.1016/j.cps.2008.08.005 [doi] PP - ppublish LG - English DP - 2009 Jan EZ - 2008/12/06 09:00 DA - 2009/03/20 09:00 DT - 2008/12/06 09:00 YR - 2009 ED - 20090319 RD - 20081205 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19055971 <460. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19182584 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Otterburn D AU - Losken A FA - Otterburn, David FA - Losken, Albert IN - Otterburn, David. Emory Division of Plastic and Reconstructive Surgery, Atlanta, GA 30308, USA. TI - The use of porcine acellular dermal material for TRAM flap donor-site closure. SO - Plastic & Reconstructive Surgery. 123(2):74e-76e, 2009 Feb AS - Plast Reconstr Surg. 123(2):74e-76e, 2009 Feb NJ - Plastic and reconstructive surgery VO - 123 IP - 2 PG - 74e-76e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Abdominal Wall/su [Surgery] MH - Adult MH - Aged MH - Animals MH - *Biocompatible Materials MH - Collagen MH - *Dermis MH - Fasciotomy MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications MH - *Rectus Abdominis/su [Surgery] MH - *Surgical Flaps MH - Swine RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31819597d4 PT - Clinical Trial PT - Journal Article ID - 10.1097/PRS.0b013e31819597d4 [doi] ID - 00006534-200902000-00072 [pii] PP - ppublish LG - English DP - 2009 Feb EZ - 2009/02/03 09:00 DA - 2009/03/03 09:00 DT - 2009/02/03 09:00 YR - 2009 ED - 20090302 RD - 20161125 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19182584 <461. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19116505 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Becker S AU - Saint-Cyr M AU - Wong C AU - Dauwe P AU - Nagarkar P AU - Thornton JF AU - Peng Y FA - Becker, Stephen FA - Saint-Cyr, Michel FA - Wong, Corrine FA - Dauwe, Phillip FA - Nagarkar, Purushottam FA - Thornton, James F FA - Peng, Yan IN - Becker, Stephen. Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9132, USA. TI - AlloDerm versus DermaMatrix in immediate expander-based breast reconstruction: a preliminary comparison of complication profiles and material compliance. SO - Plastic & Reconstructive Surgery. 123(1):1-6; discussion 107-8, 2009 Jan AS - Plast Reconstr Surg. 123(1):1-6; discussion 107-8, 2009 Jan NJ - Plastic and reconstructive surgery VO - 123 IP - 1 PG - 1-6; discussion 107-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Biocompatible Materials/tu [Therapeutic Use] MH - Breast Neoplasms/ge [Genetics] MH - Breast Neoplasms/su [Surgery] MH - *Collagen MH - Genes, BRCA1 MH - Humans MH - *Mammaplasty MH - Mastectomy MH - Middle Aged MH - Prospective Studies MH - Retrospective Studies MH - Skin, Artificial MH - *Tissue Expansion Devices AB - BACKGROUND: Allogenic acellular dermal matrix can be used in single-stage, expander-based immediate and delayed breast reconstructions to provide inferolateral prosthesis coverage and reconstruction of the inframammary fold. Two allogenic dermal matrix products currently available, AlloDerm and DermaMatrix, differ in method of storage, cost, and intraoperative preparation. The purpose of this study was to determine, first, whether there are any significant differences in the rates of postoperative complications, material compliance, or capsule characteristics; and second, if differences are present, whether they had any impact on final outcome. AB - METHODS: After institutional review board approval, a retrospective analysis of prospectively collected data of 30 patients (50 breasts) who underwent immediate expander-based breast reconstructions using either AlloDerm (n = 25) or DermaMatrix (n = 25) dermal substitutes was performed. Primary endpoints were (1) incidence of seroma, (2) wound infection, (3) number of days requiring drains, (4) rate of tissue expansion, (5) final expanded volume, (6) final implant volume, and (7) neovascularization. AB - RESULTS: The mean follow-up was 6.7 months. During this time, no significant differences in the complication profile were found between the two groups. Both dermal substitutes were found to be well incorporated, with evidence of neovascularization, on histologic examination. AB - CONCLUSIONS: This study demonstrated no significant differences in the rate of complications or material compliance. The total complication rate was 4 percent, with seroma and wound infection being the most common complications. The authors' preliminary findings indicate no significant difference between implant/expander-based reconstructions using AlloDerm and those using DermaMatrix. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e3181904bff PT - Clinical Trial PT - Comparative Study PT - Journal Article ID - 10.1097/PRS.0b013e3181904bff [doi] ID - 00006534-200901000-00001 [pii] PP - ppublish LG - English DP - 2009 Jan EZ - 2009/01/01 09:00 DA - 2009/02/24 09:00 DT - 2009/01/01 09:00 YR - 2009 ED - 20090223 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=19116505 <462. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18948774 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Topol BM AU - Dalton EF AU - Ponn T AU - Campbell CJ FA - Topol, Bruce M FA - Dalton, Edward F FA - Ponn, Teresa FA - Campbell, Connie J IN - Topol, Bruce M. Department of Surgery, Section of Plastic Surgery, The Elliot Hospital and Catholic Medical Center, Manchester, NH, USA. drtopol@drtopol.com TI - Immediate single-stage breast reconstruction using implants and human acellular dermal tissue matrix with adjustment of the lower pole of the breast to reduce unwanted lift. SO - Annals of Plastic Surgery. 61(5):494-9, 2008 Nov AS - Ann Plast Surg. 61(5):494-9, 2008 Nov NJ - Annals of plastic surgery VO - 61 IP - 5 PG - 494-9 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty MH - Surgical Flaps AB - Breast reconstruction using implants remains an aesthetic challenge toward achieving symmetry and natural appearance. Closing the areolar defect results in a vertically elevated breast mound. The use of human acellular dermal tissue matrix has been reported to provide coverage and durability over breast implants while allowing for improved shape of the reconstructed breast. This study reports the operative technique used in a series of breast reconstructions using saline implants and human acellular dermal tissue matrix in an immediate one-stage procedure. Complications and appearance were evaluated for all reconstructions. Indications for inframammary fold reconstruction and lower pole breast enhancement using chest skin advancement were discussed. Twenty-three patients were included in the study; 11 had unilateral reconstruction and 12 had bilateral reconstruction for 35 total reconstructions. All patients had immediate reconstruction following skin-sparing mastectomy. Nine patients had inframammary fold reconstruction and 11 patients had a lower chest advancement flap with fold reconstruction. The mean follow-up was 9.5 months with a range of 1 to 24 months. Complications occurred in 3 patients. Human acellular dermal tissue matrix can successfully be used in conjunction with breast implants to achieve an aesthetically pleasing breast reconstruction in one stage at the time of skin-sparing mastectomy. The use of a tissue expander and its associated risks and costs are eliminated. The complication rate is low. In addition, either inframammary fold reconstruction or lower chest advancement and fold reconstruction to augment lower pole skin coverage can improve symmetry with the opposite breast. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31816d82d9 PT - Case Reports PT - Journal Article ID - 10.1097/SAP.0b013e31816d82d9 [doi] ID - 00000637-200811000-00005 [pii] PP - ppublish LG - English DP - 2008 Nov EZ - 2008/10/25 09:00 DA - 2009/02/07 09:00 DT - 2008/10/25 09:00 YR - 2008 ED - 20090206 RD - 20081024 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18948774 <463. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18575951 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ashikari RH AU - Ashikari AY AU - Kelemen PR AU - Salzberg CA FA - Ashikari, Roy H FA - Ashikari, Andrew Y FA - Kelemen, Pond R FA - Salzberg, C Andrew IN - Ashikari, Roy H. Ashikari Breast Center, 128 Ashford Avenue, Dobbs Ferry, NY 10522, USA. TI - Subcutaneous mastectomy and immediate reconstruction for prevention of breast cancer for high-risk patients. SO - Breast Cancer. 15(3):185-91, 2008 AS - Breast Cancer. 15(3):185-91, 2008 NJ - Breast cancer (Tokyo, Japan) VO - 15 IP - 3 PG - 185-91 PI - Journal available in: Print PI - Citation processed from: Internet JC - 100888201, due IO - Breast Cancer SB - Index Medicus CP - Japan MH - Adult MH - Aged MH - Breast Neoplasms/di [Diagnosis] MH - *Breast Neoplasms/pc [Prevention & Control] MH - Breast Neoplasms/su [Surgery] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - *Mastectomy, Subcutaneous/mt [Methods] MH - Middle Aged MH - Patient Satisfaction MH - Quality of Life MH - Retrospective Studies MH - Risk Factors MH - Treatment Outcome AB - Breast cancer is the most common malignant tumor among females in the USA, with one out of eight American females developing breast cancer in their lifetimes. The latest studies show that 212,920 new cases of invasive cancer developed in 2006, which is 2.5 times more common than the incidence of lung cancer, and that 40,970 females will die from this disease each year. Therefore, awareness of this cancer is an important health issue, with more women beginning to assess their risk of breast cancer, either informally or with instruments such as the GAIL model. The availability of genetic testing for BRCA-1 and BRCA-2 has revealed many women who are at significantly increased risk. Many aggressive surveillance programs have been developed using advanced MRI and ultrasound, and reductions in breast cancer risk of 50% or more have been proven using chemoprevention strategies with tamoxifen and raloxifene. However, many women are starting to seriously consider prophylactic mastectomy for near-total reduction of breast cancer risk. At our institution, we have developed a procedure for prophylactic subcutaneous mastectomy via an inframammary incision that spares the nipple and is combined with immediate silicone implant reconstruction with the assistance of Alloderm. In this article we will describe the procedure and some of the important issues surrounding its implementation from our experience. ES - 1880-4233 IL - 1340-6868 DO - https://dx.doi.org/10.1007/s12282-008-0059-7 PT - Lectures ID - 10.1007/s12282-008-0059-7 [doi] PP - ppublish LG - English DP - 2008 EZ - 2008/06/26 09:00 DA - 2009/02/04 09:00 DT - 2008/06/26 09:00 YR - 2008 ED - 20090203 RD - 20080701 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18575951 <464. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18338102 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Spear SL AU - Parikh PM AU - Reisin E AU - Menon NG FA - Spear, S L FA - Parikh, P M FA - Reisin, E FA - Menon, N G IN - Spear, S L. Department of Plastic Surgery, Georgetown University, 1st Floor PHC Building, 3800 Reservoir Road NW, Washington, DC 20007, USA. TI - Acellular dermis-assisted breast reconstruction. SO - Aesthetic Plastic Surgery. 32(3):418-25, 2008 May AS - Aesthetic Plast Surg. 32(3):418-25, 2008 May NJ - Aesthetic plastic surgery VO - 32 IP - 3 PG - 418-25 PI - Journal available in: Print PI - Citation processed from: Print JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast/su [Surgery] MH - Breast Implants MH - *Dermis/tr [Transplantation] MH - Female MH - Humans MH - *Mastectomy MH - Middle Aged MH - Prospective Studies MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Tissue Expansion Devices MH - Transplantation, Homologous AB - BACKGROUND: In 2004, the authors reported their findings with placement of tissue expanders for breast reconstruction in the partial submuscular position, the equivalent of the "dual-plane" technique for breast augmentation. Limitations with subpectoral expander placement include difficulty controlling the lower pole of the pocket during expansion, unprotected device coverage by a thin inferior mastectomy flap, possible effacement of the inframammary fold, and limited control over the superior migration of the pectoralis major muscle. This study aimed to examine the safety and efficacy of an acellular dermal sling in providing inferolateral support to the device during immediate breast reconstruction and expansion. AB - METHODS: This study prospectively investigated 58 breasts of 43 consecutive women who underwent immediate breast reconstruction with tissue expanders and acellular dermis. After completion of adjuvant therapy and expansion, the devices were exchanged for implants. The patients were tracked through January, 2007. The study parameters included demographic information, oncologic data, complications, and aesthetic outcomes. AB - RESULTS: The mean time required to complete reconstruction was 8.6 months. The overall complication rate after expander/acellular dermis placement was 12%, whereas the complication rate after exchange to implants was 2.2%. The aesthetic outcome for reconstructed breasts did not differ significantly from that for the control subjects who had no surgery. AB - CONCLUSIONS: Acellular dermis appears to be a useful adjunct in immediate prosthetic breast reconstruction. Acellular dermis-assisted breast reconstruction has a low complication rate, helps to reconstruct an aesthetically pleasing breast, and facilitates expeditious completion of the reconstruction. IS - 0364-216X IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-008-9128-8 PT - Journal Article ID - 10.1007/s00266-008-9128-8 [doi] PP - ppublish LG - English DP - 2008 May EZ - 2008/03/14 09:00 DA - 2008/10/24 09:00 DT - 2008/03/14 09:00 YR - 2008 ED - 20081023 RD - 20080602 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18338102 <465. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18650604 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Colwell AS AU - Breuing KH FA - Colwell, Amy S FA - Breuing, Karl H IN - Colwell, Amy S. Division of Plastic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. TI - Improving shape and symmetry in mastopexy with autologous or cadaveric dermal slings. SO - Annals of Plastic Surgery. 61(2):138-42, 2008 Aug AS - Ann Plast Surg. 61(2):138-42, 2008 Aug NJ - Annals of plastic surgery VO - 61 IP - 2 PG - 138-42 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Algorithms MH - *Body Image MH - Body Mass Index MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty MH - Middle Aged MH - Retrospective Studies MH - Skin Transplantation MH - *Somatotypes MH - *Transplantation, Autologous MH - Weight Loss AB - Mastopexy and reduction mammaplasty reshape breast parenchyma and restore youthful contour in women with ptotic breasts. However, recurrent ptosis and breast base widening are common. We have been using internal autologous or cadaveric (AlloDerm) dermal slings to circumferentially support and shape the breasts for symmetry or rejuvenation. Ten patients underwent unilateral mastopexy (3), unilateral reduction-mastopexy (1), bilateral mastopexy (5), or bilateral reduction-mastopexy (1) with an internal dermal sling to correct breast reconstruction asymmetry (2), congenital asymmetry (2), or acquired ptosis (6). Three of 6 patients acquired breast ptosis after massive weight loss. Autologous dermis was used in 5 patients, and 5 patients were reconstructed with AlloDerm. Patients have maintained projection and breast base width after 6 months to 3 years. In conclusion, internal dermal slings improve shape, breast projection, and base width in select patients undergoing mastopexy. An algorithm based on quantity and quality of native skin is provided. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31815bfe7c PT - Journal Article ID - 10.1097/SAP.0b013e31815bfe7c [doi] ID - 00000637-200808000-00005 [pii] PP - ppublish LG - English DP - 2008 Aug EZ - 2008/07/25 09:00 DA - 2008/10/03 09:00 DT - 2008/07/25 09:00 YR - 2008 ED - 20081002 RD - 20080724 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18650604 <466. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18594354 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nipshagen MD AU - Hage JJ AU - Beekman WH FA - Nipshagen, Martine D FA - Hage, J Joris FA - Beekman, Werner H IN - Nipshagen, Martine D. Department of Plastic Surgery, Tergooi Hospital, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Hilversum, The Netherlands. md.nipshagen@tiscali.nl TI - Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: a prospective, randomized intervention study. CM - Comment in: Plast Reconstr Surg. 2009 Aug;124(2):669; PMID: 19644305 SO - Plastic & Reconstructive Surgery. 122(1):10-8, 2008 Jul AS - Plast Reconstr Surg. 122(1):10-8, 2008 Jul NJ - Plastic and reconstructive surgery VO - 122 IP - 1 PG - 10-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Administration, Topical MH - Adult MH - *Cyanoacrylates/ad [Administration & Dosage] MH - Female MH - Humans MH - *Mammaplasty MH - Middle Aged MH - Prospective Studies MH - *Tissue Adhesives/ad [Administration & Dosage] MH - Wounds and Injuries/et [Etiology] MH - *Wounds and Injuries/th [Therapy] AB - BACKGROUND: 2-Octyl-cyanoacrylate skin adhesive may be used for surgical wound closure. However, its use in plastic surgery has not been properly assessed. AB - METHODS: The authors conducted a prospective, randomized, controlled clinical intervention study in which the scar characteristics after use of skin adhesive were compared with those after suture closure. Bilateral reduction mammaplasty was performed in 50 patients. The method of closure (sutures versus skin adhesive) applied to each breast was determined randomly, using each patient as her own control. Scars were assessed by the patient and by a blinded panel, at 1 week, 6 weeks, and 6 months after surgery, using a visual analogue scale, the modified Hollander Wound Evaluation Scale, and the Patient and Observer Scar Assessment Scale. AB - RESULTS: Both patients and panelists expressed an overall preference for the adhesive side as of 1 week after surgery. Patients' visual analogue scale scores for scar comfort and scar appearance and panelists' visual analogue scale scores for aesthetic outcome were significantly better for the adhesive side after 6 weeks and 6 months (p < 0.05), as was the total Hollander Wound Evaluation Scale score of the panelists after 6 weeks (p < 0.02). The total Patient and Observer Scar Assessment Scale score after 6 months was significantly better for the adhesive side according to the patients (p < 0.01), but not according to the panelists (p = 0.11). AB - CONCLUSION: The authors conclude that 2-octyl-cyanoacrylate is a sound alternative for wound closure. RN - 0 (Cyanoacrylates) RN - 0 (Tissue Adhesives) RN - 6C655P1XVG (octyl 2-cyanoacrylate) ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e318171524b PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't ID - 10.1097/PRS.0b013e318171524b [doi] ID - 00006534-200807000-00002 [pii] PP - ppublish LG - English DP - 2008 Jul EZ - 2008/07/03 09:00 DA - 2008/07/30 09:00 DT - 2008/07/03 09:00 YR - 2008 ED - 20080729 RD - 20161124 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18594354 <467. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18434824 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Preminger BA AU - McCarthy CM AU - Hu QY AU - Mehrara BJ AU - Disa JJ FA - Preminger, Beth Aviva FA - McCarthy, Collen M FA - Hu, Qunying Y FA - Mehrara, Babak J FA - Disa, Joseph J IN - Preminger, Beth Aviva. Division of Plastic and Reconstructive Surgery, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10065, USA. bap2104@columbia.edu TI - The influence of AlloDerm on expander dynamics and complications in the setting of immediate tissue expander/implant reconstruction: a matched-cohort study. SO - Annals of Plastic Surgery. 60(5):510-3, 2008 May AS - Ann Plast Surg. 60(5):510-3, 2008 May NJ - Annals of plastic surgery VO - 60 IP - 5 PG - 510-3 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Biomechanical Phenomena MH - Breast Neoplasms/th [Therapy] MH - Cohort Studies MH - Collagen MH - Female MH - Humans MH - *Mammaplasty MH - *Mastectomy MH - Retrospective Studies MH - Tissue Expansion/mt [Methods] MH - Tissue Expansion Devices/ae [Adverse Effects] AB - AlloDerm (LifeCell, Branchburg, NJ) is gaining acceptance in tissue expander/implant (TE/I) breast reconstruction. Anecdotal evidence suggests its use limits postoperative musculoskeletal morbidity and allows injection of greater initial fill-volumes and rapid postoperative expansion. The objective of this study was to evaluate AlloDerm's impact on expansion rates in immediate TE/I reconstruction. A matched, retrospective cohort study was performed. Medical records of patients who underwent immediate TE/I reconstruction from 2004 to 2005 were reviewed. Two cohorts were identified: (1) underwent TE/I reconstruction with AlloDerm, and (2) underwent standard TE/I reconstruction. Individuals were matched 1:1 on the basis of: expander size (+/-100 mL), history of irradiation, and indication for mastectomy. Cohorts were compared for intraoperative volume injected (mL), rate of postoperative expansion (mL/ injection), number of expansions, and time to completion of expansion (days). Incidence of complications was evaluated. Pairwise comparisons were performed using the Wilcoxon sign rank test and McNemar test. Ninety immediate TE/I reconstructions were evaluated. Forty-five TE/I-AlloDerm reconstructions were matched to standard TE/I reconstructions. Intraoperatively, expanders in the AlloDerm and non-AlloDerm cohorts were filled to a mean volume of 223.8 and 201.1 mL (P = 0.180). Median number of expansions performed was 5 and 6 in the AlloDerm and non-AlloDerm cohorts (P = 0.117). There was no difference in the mean rate of postoperative tissue expansion (AlloDerm: 97 mL/injection versus non-AlloDerm: 95 mL/injection [P = 0.907]), nor in the incidence of complications (P = 0.289). Minor complications occurred in 13.1% of AlloDerm cases (cellulitis [n = 3], seroma [n = 3], hematoma [n = 1]. Although this study does not address AlloDerm's efficacy in decreasing morbidity or improving esthetic outcomes in TE/I reconstruction, it indicates that AlloDerm does not increase the rate of tissue expansion after immediate TE placement. It does not, however, appear to increase the risk of postoperative complications. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0b013e31816f2836 PT - Journal Article ID - 10.1097/SAP.0b013e31816f2836 [doi] ID - 00000637-200805000-00009 [pii] PP - ppublish LG - English DP - 2008 May EZ - 2008/04/25 09:00 DA - 2008/06/25 09:00 DT - 2008/04/25 09:00 YR - 2008 ED - 20080624 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18434824 <468. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 18186871 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Schulman MR AU - Lipper J AU - Skolnik RA FA - Schulman, Matthew R FA - Lipper, Justin FA - Skolnik, Richard A IN - Schulman, Matthew R. Division of Plastic and Reconstructive Surgery, The Mount Sinai School of Medicine and The Mount Sinai Hospital, New York, New York, USA. matthewschulman.md@gmail.com TI - Correction of chest wall deformity after implant-based breast reconstruction using poly-L-lactic acid (Sculptra). SO - Breast Journal. 14(1):92-6, 2008 Jan-Feb AS - Breast J. 14(1):92-6, 2008 Jan-Feb NJ - The breast journal VO - 14 IP - 1 PG - 92-6 PI - Journal available in: Print PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J SB - Index Medicus CP - United States MH - *Biocompatible Materials MH - *Breast Implantation MH - *Cellulose MH - Collagen MH - Cosmetic Techniques MH - Female MH - Humans MH - *Lactic Acid MH - *Mannitol MH - *Mastectomy/ae [Adverse Effects] MH - Middle Aged MH - *Polymers MH - Postoperative Complications MH - Reoperation MH - Thoracic Surgical Procedures MH - *Thoracic Wall/su [Surgery] MH - Treatment Outcome AB - Implant-based breast reconstruction after mastectomy offers excellent cosmetic results in select individuals. However, this technique may result in a step-off between the implant and the soft tissue of the chest wall, which can be problematic in the extremely thin patient. Also, the removal of soft tissue can result in prominent ribs and visible intercostal spaces. A number of surgical options exist to correct these defects and include dermal grafts, flap reconstruction, and implant exchange. We present the case of a thin woman with a persistent "step-off" deformity and visible intercostal spaces after mastectomy and two-stage implant reconstruction. Placement of acellular cadaveric dermis (Alloderm) failed to improve the appearance of her chest wall. The authors utilized poly-L-lactic acid (Sculptra) for soft tissue augmentation of her chest wall with significant esthetic improvement. This novel use of poly-L-lactic acid offers a useful alternative to invasive surgical procedures to correct a soft tissue deformity of the chest wall. While poly-L-lactic acid has recently gained popularity for soft tissue augmentation of the face, to date, no reports in the literature exist describing its use in the correction of difficult chest wall defects after mastectomy and implant reconstruction. We maintain that poly-L-lactic acid may also be useful to improve a variety of soft tissue deformities of the breast. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 0 (New-Fill) RN - 0 (Polymers) RN - 33X04XA5AT (Lactic Acid) RN - 3OWL53L36A (Mannitol) RN - 9004-34-6 (Cellulose) RN - 9007-34-5 (Collagen) ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/j.1524-4741.2007.00529.x PT - Case Reports PT - Journal Article ID - TBJ529 [pii] ID - 10.1111/j.1524-4741.2007.00529.x [doi] PP - ppublish LG - English DP - 2008 Jan-Feb EZ - 2008/01/12 09:00 DA - 2008/02/22 09:00 DT - 2008/01/12 09:00 YR - 2008 ED - 20080221 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&AN=18186871 <469. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17459797 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Bindingnavele V AU - Gaon M AU - Ota KS AU - Kulber DA AU - Lee DJ FA - Bindingnavele, Vijay FA - Gaon, Mark FA - Ota, Ken S FA - Kulber, David A FA - Lee, Dong-Joon IN - Bindingnavele, Vijay. Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Southern California, Los Angeles, CA, USA. TI - Use of acellular cadaveric dermis and tissue expansion in postmastectomy breast reconstruction. [Review] [22 refs] SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 60(11):1214-8, 2007 AS - J Plast Reconstr Aesthet Surg. 60(11):1214-8, 2007 NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 60 IP - 11 PG - 1214-8 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101264239 IO - J Plast Reconstr Aesthet Surg SB - Index Medicus CP - Netherlands MH - Adult MH - Aged MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mammaplasty/sn [Statistics & Numerical Data] MH - Mastectomy/mt [Methods] MH - Mastectomy/sn [Statistics & Numerical Data] MH - Middle Aged MH - Patient Satisfaction MH - Retrospective Studies MH - Tissue Expansion Devices/ut [Utilization] MH - Treatment Outcome AB - Tissue expander or permanent implant coverage in postmastectomy breast reconstruction is often challenging. Multiple authors have demonstrated the use of acellular cadaveric dermis (ACD) in nonexpansive, single-stage breast reconstruction. The literature also suggests that tissue expansion may be accomplished with ACD as well for stage reconstructions. In many cases tissue expansion is necessary to create a submuscular and subACD pocket to accommodate a subsequent permanent prosthesis. In this study we report the outcomes and complication rates of using ACD in staged breast reconstruction. We reviewed the charts of 41 patients (65 breasts) in whom ACD was used in staged reconstructions. We analysed the patients' charts and operative records to determine postoperative complication rates and results. Complication rates for wound infection, expander removal, haematoma, and seroma were: 3.1% (two of 65), 1.5% (one of 65), 1.5% (one of 65), and 4.6% (three of 65), respectively. The use of ACD in expansive postmastectomy breast reconstruction has an extremely low complication rate, results in good cosmetic outcome, and should be in the repertoire of plastic surgeons. Further follow up is needed to evaluate the long term outcomes of ACD use in postmastectomy breast reconstruction. [References: 22] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 1748-6815 IL - 1748-6815 PT - Journal Article PT - Review ID - S1748-6815(07)00194-5 [pii] ID - 10.1016/j.bjps.2007.03.015 [doi] PP - ppublish PH - 2006/10/09 [received] PH - 2006/12/09 [revised] PH - 2007/03/13 [accepted] LG - English EP - 20070425 DP - 2007 EZ - 2007/04/27 09:00 DA - 2008/01/15 09:00 DT - 2007/04/27 09:00 YR - 2007 ED - 20080114 RD - 20071022 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17459797 <470. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17721209 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Breuing KH AU - Colwell AS FA - Breuing, Karl H FA - Colwell, Amy S IN - Breuing, Karl H. Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. kbreuing@partners.org TI - Inferolateral AlloDerm hammock for implant coverage in breast reconstruction. SO - Annals of Plastic Surgery. 59(3):250-5, 2007 Sep AS - Ann Plast Surg. 59(3):250-5, 2007 Sep NJ - Annals of plastic surgery VO - 59 IP - 3 PG - 250-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - *Biocompatible Materials MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Pectoralis Muscles/su [Surgery] AB - PURPOSE: Implant reconstruction is commonly performed to reconstruct mastectomy defects or to correct breast hypoplasia. We have been using an inferolateral AlloDerm hammock as an inferior extension of the pectoralis major muscle to provide a mechanical barrier between the implant and skin and to control implant position. AB - METHODS: The inferior border of the AlloDerm hammock is attached inferiorly to the rectus abdominis fascia and laterally to the serratus anterior fascia to create the borders of the implant pocket. The AlloDerm is then sewn to the pectoralis major muscle to enclose the implant. AB - RESULTS: The AlloDerm hammock was used in 43 patients and 67 breasts for immediate expander-implant reconstruction (10), immediate silicone implant reconstruction (30), delayed expander-implant reconstruction (4), and revisional implant reconstruction for capsular contracture following capsulectomy (23). The AlloDerm hammock allowed complete coverage of the implant and symmetric positioning of the inframammary fold. In delayed reconstructions with existing skin redundancy at the mastectomy site, inferior epigastric tissue was recruited and tissue expanders filled over 75% of the desired volume, thus decreasing the need for subsequent filling. Patients were overall satisfied with their results and had few complications. No capsular contracture, hematoma, or seroma was observed in 6 months to 3 years of follow-up. AB - CONCLUSION: Implant reconstruction with an inferolateral AlloDerm hammock facilitates positioning of the implant in immediate or revisional breast reconstruction and simplifies expander-implant reconstruction. This safe technique is easy to learn and should be considered a viable option for breast reconstruction. RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) IS - 0148-7043 IL - 0148-7043 PT - Journal Article ID - 10.1097/SAP.0b013e31802f8426 [doi] ID - 00000637-200709000-00003 [pii] PP - ppublish LG - English DP - 2007 Sep EZ - 2007/08/28 09:00 DA - 2007/11/02 09:00 DT - 2007/08/28 09:00 YR - 2007 ED - 20071101 RD - 20070827 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17721209 <471. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17898600 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Department of Plastic Surgery, Georgetown University, Washington, DC, USA. drnahabedian@aol.com TI - Does AlloDerm stretch?. SO - Plastic & Reconstructive Surgery. 120(5):1276-80, 2007 Oct AS - Plast Reconstr Surg. 120(5):1276-80, 2007 Oct NJ - Plastic and reconstructive surgery VO - 120 IP - 5 PG - 1276-80 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Abdomen MH - *Biocompatible Materials MH - *Collagen/ph [Physiology] MH - Elasticity MH - Female MH - Humans MH - Mammaplasty MH - Middle Aged MH - *Postoperative Complications/th [Therapy] MH - Recurrence MH - Surgical Flaps MH - Surgical Mesh RN - 0 (Alloderm) RN - 0 (Biocompatible Materials) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Case Reports PT - Journal Article ID - 10.1097/01.prs.0000279342.48795.9a [doi] ID - 00006534-200710000-00021 [pii] PP - ppublish LG - English DP - 2007 Oct EZ - 2007/09/28 09:00 DA - 2007/10/20 09:00 DT - 2007/09/28 09:00 YR - 2007 ED - 20071019 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17898600 <472. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17667419 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Liao EC AU - Breuing KH FA - Liao, Eric C FA - Breuing, Karl H IN - Liao, Eric C. Division of Plastic Surgery, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02115, USA. TI - Breast mound salvage using vacuum-assisted closure device as bridge to reconstruction with inferolateral AlloDerm hammock. SO - Annals of Plastic Surgery. 59(2):218-24, 2007 Aug AS - Ann Plast Surg. 59(2):218-24, 2007 Aug NJ - Annals of plastic surgery VO - 59 IP - 2 PG - 218-24 PI - Journal available in: Print PI - Citation processed from: Print JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Aged, 80 and over MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Salvage Therapy MH - *Skin, Artificial MH - Vacuum RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 0148-7043 IL - 0148-7043 PT - Case Reports PT - Journal Article ID - 10.1097/SAP.0b013e31802c148c [doi] ID - 00000637-200708000-00019 [pii] PP - ppublish LG - English DP - 2007 Aug EZ - 2007/08/02 09:00 DA - 2007/10/04 09:00 DT - 2007/08/02 09:00 YR - 2007 ED - 20071003 RD - 20070801 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17667419 <473. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17632337 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Zienowicz RJ AU - Karacaoglu E FA - Zienowicz, Richard J FA - Karacaoglu, Ercan IN - Zienowicz, Richard J. School of Medicine, Brown University, Providence, RI, USA. TI - Implant-based breast reconstruction with allograft. SO - Plastic & Reconstructive Surgery. 120(2):373-81, 2007 Aug AS - Plast Reconstr Surg. 120(2):373-81, 2007 Aug NJ - Plastic and reconstructive surgery VO - 120 IP - 2 PG - 373-81 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - *Breast Implants MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Middle Aged MH - *Skin, Artificial AB - BACKGROUND: Reconstructive breast surgeons often prefer autologous tissue for those patients who can tolerate it. However, reconstruction with implants is technically easier, quicker, less traumatic, and less costly. Nevertheless, inherent problems associated with implants present some limitations to their use in reconstruction. In this study, a multipurpose application of allogenic dermal grafts to solve the problems seen in immediate breast reconstruction with implants was examined. AB - METHODS: After skin-sparing mastectomy, a subpectoral pocket is created for the implant. After the origins of the pectoralis major muscle are released, AlloDerm is sewn to the lower pole of the released muscle. Grafts are tailored according to the dimensions of the defect. AlloDerm, an allogenic dermal graft, is fixed to the pectoralis major superiorly, to the chest wall inferiorly and inferomedially, and to the serratus anterior flap laterally. A postoperative adjustable implant is placed into the pocket that has bene created. AB - RESULT: Allografts were used to reconstruct 30 breasts in 24 patients immediately after skin- or nipple-sparing mastectomy. There was no complication related to simultaneous allograft application. No rippling, symmastia, or bottoming-out deformity was seen. AB - CONCLUSIONS: Breast reconstruction with implant and AlloDerm enables the surgeon to create a submuscular pocket large enough to place a fully inflated breast implant. Interposition of a lower-pole internal sling, to increase the capacity of the pectoralis major pocket while providing immediate ability to achieve full or subtotal prosthetic fill and optimal aesthetic breast contouring and to maintain thicker muscle coverage in the upper and medial pole areas and stronger lower pole support, would obviate many of the current disadvantages to implant reconstruction. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Journal Article ID - 10.1097/01.prs.0000267340.31742.1 [doi] ID - 00006534-200708000-00002 [pii] PP - ppublish LG - English DP - 2007 Aug EZ - 2007/07/17 09:00 DA - 2007/07/26 09:00 DT - 2007/07/17 09:00 YR - 2007 ED - 20070725 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17632337 <474. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17440338 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Garramone CE AU - Lam B FA - Garramone, Charles E FA - Lam, Benjamin IN - Garramone, Charles E. Department of Plastic and Reconstructive Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA. cgarramone@yahoo.com TI - Use of AlloDerm in primary nipple reconstruction to improve long-term nipple projection. SO - Plastic & Reconstructive Surgery. 119(6):1663-8, 2007 May AS - Plast Reconstr Surg. 119(6):1663-8, 2007 May NJ - Plastic and reconstructive surgery VO - 119 IP - 6 PG - 1663-8 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/su [Surgery] MH - *Collagen/tu [Therapeutic Use] MH - Esthetics MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy/mt [Methods] MH - *Nipples/su [Surgery] MH - Patient Satisfaction MH - Prospective Studies MH - Risk Assessment MH - Skin, Artificial MH - Tissue Expansion/mt [Methods] MH - Wound Healing/ph [Physiology] AB - BACKGROUND: The objective of this study was to demonstrate the use of the authors' technique to improve long-term maintenance of nipple projection by using AlloDerm (LifeCell Corp., Branchburg, N.J.) as a central core in nipple reconstruction. AB - METHODS: The nipple reconstruction technique involved the use of a modified star dermal flap pattern measuring 5 cm in length and 1.0 to 1.5 cm in width, depending on the amount of desired projection to match the opposite nipple. Then, a 1.5 x 4.5-cm piece of AlloDerm was placed into the core of the newly reconstructed nipple and sutured closed. After the incisions were closed, an ocular eye bubble protector was used to prevent compressive forces on the newly reconstructed nipple, and strict postoperative use of this protector was maintained for 6 weeks. AB - RESULTS: A total of 30 nipple reconstructions were performed [14 transverse rectus abdominis musculocutaneous (TRAM) flaps and 16 tissue-expanded breast mounds]. Caliper measurements of nipple projection were recorded at the time of surgery and at 3, 6, and 12 months postoperatively. Twelve-month average maintenance of nipple projection was 56 percent for the TRAM flap group and 47 percent for the tissue-expanded group. There were no infections or associated complications. AB - CONCLUSIONS: The authors' results demonstrate that the use of a modified star dermal flap pattern with the placement of an AlloDerm graft core is a safe, easily performed, and reproducible technique for improving the long-term maintenance of projection in reconstructed nipples. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Comparative Study PT - Journal Article ID - 10.1097/01.prs.0000258831.38615.80 [doi] ID - 00006534-200705000-00004 [pii] PP - ppublish LG - English DP - 2007 May EZ - 2007/04/19 09:00 DA - 2007/05/03 09:00 DT - 2007/04/19 09:00 YR - 2007 ED - 20070502 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17440338 <475. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 16799299 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Salzberg CA FA - Salzberg, C Andrew IN - Salzberg, C Andrew. Department of Surgery-Section of Plastic Surgery, New York Medical College, Valhalla, 10591, USA. asalzbergmd@yahoo.com TI - Nonexpansive immediate breast reconstruction using human acellular tissue matrix graft (AlloDerm). SO - Annals of Plastic Surgery. 57(1):1-5, 2006 Jul AS - Ann Plast Surg. 57(1):1-5, 2006 Jul NJ - Annals of plastic surgery VO - 57 IP - 1 PG - 1-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Biopsy MH - Breast/pa [Pathology] MH - Breast Implantation MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Follow-Up Studies MH - Humans MH - *Mammaplasty/mt [Methods] MH - Mastectomy MH - Treatment Outcome AB - Immediate breast reconstruction has become a standard of care following mastectomy for cancer, largely due to improved esthetic and psychologic outcomes achieved with this technique. However, the current historical standards--transverse rectus abdominis myocutaneous flap reconstruction and expander--implant surgery-still have limitations as regards patient morbidity, short-term body-image improvements, and even cost. To address these shortcomings, we employ a novel concept of human tissue replacement to enhance breast shape and provide total coverage, enabling immediate mound reconstruction without the need for breast expansion prior to permanent implant placement. AlloDerm (human acellular tissue matrix) is a human-derived graft tissue with extensive experience in various settings of skin and soft tissue replacement surgery. This report describes the success using acellular tissue matrix to provide total coverage over the prosthesis in immediate reconstruction, with limited muscle dissection. In this population, 49 patients (76 breasts) successfully underwent the acellular tissue matrix-based immediate reconstruction, resulting in durable breast reconstruction with good symmetry. These findings may predict that acellular tissue matrix-supplemented immediate breast reconstruction will become a new technique for the immediate reconstruction of the postmastectomy breast. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 0148-7043 IL - 0148-7043 PT - Journal Article ID - 10.1097/01.sap.0000214873.13102.9f [doi] ID - 00000637-200607000-00001 [pii] PP - ppublish LG - English DP - 2006 Jul EZ - 2006/06/27 09:00 DA - 2006/12/09 09:00 DT - 2006/06/27 09:00 YR - 2006 ED - 20061207 RD - 20060626 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16799299 <476. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 17033231 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Inaji H AU - Sakai K AU - Oka T AU - Ozawa K AU - Saito Y AU - Senoo T AU - Taguchi T AU - Terasawa T AU - Nakao K AU - Mori T AU - Koyama H AU - Oshima A FA - Inaji, Hideo FA - Sakai, Katsuji FA - Oka, Takahiro FA - Ozawa, Kazue FA - Saito, Yoichi FA - Senoo, Tsuneaki FA - Taguchi, Tetsuo FA - Terasawa, Toshio FA - Nakao, Kazuyasu FA - Mori, Takesada FA - Koyama, Hiroki FA - Oshima, Akira IN - Inaji, Hideo. Osaka Medical Center for Cancer and Cardiovascular Diseases. TI - [A randomized controlled study comparing uracil-tegafur (UFT)+tamoxifen (UFT+TAM therapy) with cyclophosphamide+adriamycin+5-fluorouracil (CAF therapy) for women with stage I , II, or IIIa breast cancer with four or more involved nodes in the adjuvant setting]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 33(10):1423-9, 2006 Oct AS - Gan To Kagaku Ryoho. 33(10):1423-9, 2006 Oct NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 33 IP - 10 PG - 1423-9 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Anorexia/ci [Chemically Induced] MH - Antineoplastic Agents, Hormonal/ad [Administration & Dosage] MH - Antineoplastic Combined Chemotherapy Protocols/ad [Administration & Dosage] MH - Antineoplastic Combined Chemotherapy Protocols/ae [Adverse Effects] MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/mo [Mortality] MH - *Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Chemotherapy, Adjuvant MH - Combined Modality Therapy MH - Cyclophosphamide/ad [Administration & Dosage] MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - Leukopenia/ci [Chemically Induced] MH - *Lymph Nodes/pa [Pathology] MH - Lymphatic Metastasis MH - Mastectomy MH - Middle Aged MH - Neoplasm Staging MH - Survival Rate MH - Tamoxifen/ad [Administration & Dosage] MH - Tegafur/ad [Administration & Dosage] MH - Uracil/ad [Administration & Dosage] MH - Vomiting, Anticipatory/et [Etiology] AB - We performed a controlled study to compare the response to cyclophosphamide (CPA), adriamycin (ADM), and fluorouracil (5-FU) (CAF therapy) with that to uracil-tegafur (UFT) plus tamoxifen (TAM) (UFT+TAM therapy), when given as postoperative adjuvant therapy to women with breast cancer. The patients were registered from September 1991 through February 1995 at 51 institutions in the Kinki district of Japan. All patients had stage I, II, or IIIa breast cancer with four or more lymph-node metastases and underwent mastectomy. CAF therapy and UFT+TAM therapy were started within 4 weeks after surgery. CAF therapy consisted of CPA (100 mg/day) on days 1 to 14, followed by 2 weeks of rest, plus ADM (20 mg/m(2)/day) on days 1 and 8 and 5-FU (300 mg/m(2)/day) on days 1 and 8. A total of 6 courses were delivered. UFT+TAM therapy consisted of 3 years of UFT (400 mg/day) plus TAM (20 mg/day), given daily. CAF therapy and UFT+TAM therapy were each assigned to 82 patients. The 5-year survival rate was significantly higher in the UFT+TAM group (82.1%) than in the CAF group (66.2%; p=0.04, logrank test). The 5-year relapse-free survival rate was higher in the UFT+TAM group (61.8%) than in the CAF group (46.3%; p=0.07, logrank test). As for adverse events, the rates of leukopenia, anorexia, nausea and vomiting, general malaise, and hair loss were lower in the UFT+TAM group than in the CAF group. These results suggest that long-term treatment with UFT+TAM may be a useful alternative adjuvant therapy for the management of breast cancer, especially in elderly patients. RN - 0 (Antineoplastic Agents, Hormonal) RN - 094ZI81Y45 (Tamoxifen) RN - 1548R74NSZ (Tegafur) RN - 56HH86ZVCT (Uracil) RN - 80168379AG (Doxorubicin) RN - 8N3DW7272P (Cyclophosphamide) RN - U3P01618RT (Fluorouracil) PS - 1-UFT protocol; CAF protocol IS - 0385-0684 IL - 0385-0684 PT - Comparative Study PT - English Abstract PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PP - ppublish LG - Japanese DP - 2006 Oct EZ - 2006/10/13 09:00 DA - 2006/11/11 09:00 DT - 2006/10/13 09:00 YR - 2006 ED - 20061109 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17033231 <477. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 16816665 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Glasberg SB AU - D'Amico RA FA - Glasberg, Scot B FA - D'Amico, Richard A IN - Glasberg, Scot B. Division of Plastic Surgery, Lenox Hill Hospital, New York, NY, USA. scotbg@juno.com TI - Use of regenerative human acellular tissue (AlloDerm) to reconstruct the abdominal wall following pedicle TRAM flap breast reconstruction surgery. SO - Plastic & Reconstructive Surgery. 118(1):8-15, 2006 Jul AS - Plast Reconstr Surg. 118(1):8-15, 2006 Jul NJ - Plastic and reconstructive surgery VO - 118 IP - 1 PG - 8-15 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Abdominal Wall/su [Surgery] MH - Adult MH - *Collagen MH - Female MH - Humans MH - Mammaplasty/ae [Adverse Effects] MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - *Prostheses and Implants MH - Seroma/ep [Epidemiology] MH - *Skin, Artificial MH - *Surgical Flaps MH - Tissue and Organ Harvesting AB - BACKGROUND: Harvest of transverse rectus abdominis musculocutaneous (TRAM) flaps for breast reconstruction leaves a variable defect in the anterior rectus fascia. Inadequate closure of the defect could lead to the development of hernia or abdominal wall bulging. Various techniques have been developed to reduce the incidence of hernia and abdominal wall bulging. The authors describe a novel technique of using a regenerative human acellular matrix (AlloDerm) as a fascial substitute in closing the defect. AB - METHODS: Fifty-four consecutive patients who opted for pedicle TRAM flap procedures for breast reconstruction postmastectomy were scheduled for donor-site repair with the use of AlloDerm. AlloDerm was placed interpositionally as an inlay graft to mimic the anterior rectus fascia. AB - RESULTS: Hernia or infection did not develop in any of the patients. There was a greater incidence of seroma and bulging among the first 18 patients, with eight seromas (44.4 percent) and six bulges (33.3 percent). When the technique was ameliorated in the next 36 patients, there was a reduction in the incidence of seromas (16.7 percent, p = 0.03) and bulges (16.7 percent, p = 0.17). Of the three patients who experienced wound dehiscence, partial AlloDerm exposure occurred in two, but was resolved without further consequences. Biopsy specimens of AlloDerm, obtained 12 and 14 months after TRAM donor-site repair, showed full tissue integration. The cell density, vasculature, and collagen orientation in the biopsies were consistent with abdominal fascia tissue. AB - CONCLUSION: Based on these results, the authors recommend the use of AlloDerm as an alternative option for abdominal fascia closure after TRAM flap harvest for breast reconstruction. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Journal Article ID - 10.1097/01.prs.0000220470.97776.f5 [doi] ID - 00006534-200607000-00003 [pii] PP - ppublish LG - English DP - 2006 Jul EZ - 2006/07/04 09:00 DA - 2006/08/09 09:00 DT - 2006/07/04 09:00 YR - 2006 ED - 20060808 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16816665 <478. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 16374090 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gamboa-Bobadilla GM FA - Gamboa-Bobadilla, G Mabel IN - Gamboa-Bobadilla, G Mabel. Section of Plastic Surgery, Department of Surgery, Medical College of Georgia, Augusta, GA 30901-4080, USA. MGamboa@mcg.edu TI - Implant breast reconstruction using acellular dermal matrix. SO - Annals of Plastic Surgery. 56(1):22-5, 2006 Jan AS - Ann Plast Surg. 56(1):22-5, 2006 Jan NJ - Annals of plastic surgery VO - 56 IP - 1 PG - 22-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Implantation/mt [Methods] MH - *Collagen MH - Female MH - Humans MH - *Matrix Bands MH - Middle Aged MH - Pectoralis Muscles/su [Surgery] MH - *Reconstructive Surgical Procedures/mt [Methods] AB - Thirteen breast reconstructions in 11 patients, averaging 58 years of age, underwent mastectomies. The technique uses a saline implant either totally or partially covered with a human acellular dermal matrix. The mean postoperative follow-up time was 14 months. Ninety percent of the patients were considered high risk; the thickness of the human acellular dermal matrix was an average of 1.3 mm, with an average area per breast of 121 cm. There were 12 successful breast reconstructions (92%) that provided stability, increased soft tissue padding, which allowed a greater resemblance to normal breast shape and decreased rippling and implant visibility. The graft was used in an onlay fashion or as an extension of the pectoralis major muscle that covers the implant. A representative histologic cross-section of well-integrated human acellular dermal matrix is presented. The use of a human acellular dermal matrix in breast reconstruction is an alternative protocol in high-risk patients, resulting in a minimal increase in operative time and a decrease in morbidity compared with more extensive procedures. RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 0148-7043 IL - 0148-7043 PT - Journal Article ID - 00000637-200601000-00004 [pii] PP - ppublish LG - English DP - 2006 Jan EZ - 2005/12/24 09:00 DA - 2006/05/04 09:00 DT - 2005/12/24 09:00 YR - 2006 ED - 20060502 RD - 20091103 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16374090 <479. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 15923855 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nahabedian MY FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Division of Plastic and Reconstructive Surgery, The Johns Hopkins University, Baltimore, MD, USA. moandanissa@aol.com TI - Secondary nipple reconstruction using local flaps and AlloDerm. SO - Plastic & Reconstructive Surgery. 115(7):2056-61, 2005 Jun AS - Plast Reconstr Surg. 115(7):2056-61, 2005 Jun NJ - Plastic and reconstructive surgery VO - 115 IP - 7 PG - 2056-61 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Collagen/tu [Therapeutic Use] MH - Female MH - Humans MH - Mammaplasty/mt [Methods] MH - *Mammaplasty MH - *Nipples/su [Surgery] MH - Reoperation MH - Retrospective Studies MH - *Skin, Artificial MH - Surgical Flaps RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) ES - 1529-4242 IL - 0032-1052 PT - Journal Article ID - 00006534-200506000-00034 [pii] PP - ppublish LG - English DP - 2005 Jun EZ - 2005/06/01 09:00 DA - 2006/01/18 09:00 DT - 2005/06/01 09:00 YR - 2005 ED - 20060113 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=15923855 <480. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 16307944 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Margulies AG AU - Hochberg J AU - Kepple J AU - Henry-Tillman RS AU - Westbrook K AU - Klimberg VS FA - Margulies, Aaron G FA - Hochberg, Julio FA - Kepple, Julie FA - Henry-Tillman, Ronda S FA - Westbrook, Kent FA - Klimberg, V Suzanne IN - Margulies, Aaron G. Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA. TI - Total skin-sparing mastectomy without preservation of the nipple-areola complex. SO - American Journal of Surgery. 190(6):907-12, 2005 Dec AS - Am J Surg. 190(6):907-12, 2005 Dec NJ - American journal of surgery VO - 190 IP - 6 PG - 907-12 PI - Journal available in: Print PI - Citation processed from: Print JC - 3z4, 0370473 IO - Am. J. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - Adult MH - Aged MH - *Breast Neoplasms/su [Surgery] MH - *Dermatologic Surgical Procedures MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy/mt [Methods] MH - Middle Aged MH - *Nipples/su [Surgery] MH - *Reconstructive Surgical Procedures/mt [Methods] MH - Retrospective Studies MH - Surgical Flaps MH - Treatment Outcome AB - BACKGROUND: We hypothesized that total skin-sparing mastectomy (TSM) including where the skin overlying the nipple and areola is preserved would be oncologically safe and facilitate improved cosmetic reconstruction. AB - METHODS: A review (May 2003 through January 2005) was completed on all procedures that were performed through an inframammary incision or a previous scar with reconstruction using Botox, AlloDerm, and a subpectoral tissue implant. AB - RESULTS: Thirty-one patients had 50 TSMs. Twelve percent (6/50) of TSMs had the skin of the nipple and areola resected: 4 (14% of tumors) because of tumor involvement and 2 (4%) because of skin necrosis. Fourteen percent of patients had other complications: 4% (2/50) had infection and/or flap necrosis and 10% (5/50) had superficial epidermolysis requiring no intervention, for a total complication rate of 18%. Average cosmetic score was 8.5 (range 4 to 10). No recurrences are evident after mean follow-up of 7.9 +/- 5.4 months. AB - CONCLUSION: Our short-term experience suggests that TSM has an acceptable complication rate, is theoretically oncologically safe, and facilitates an improved cosmetic result. IS - 0002-9610 IL - 0002-9610 PT - Comparative Study PT - Journal Article ID - S0002-9610(05)00717-8 [pii] ID - 10.1016/j.amjsurg.2005.08.019 [doi] PP - ppublish PH - 2005/04/11 [received] PH - 2005/08/08 [revised] PH - 2005/08/08 [accepted] LG - English DP - 2005 Dec EZ - 2005/11/26 09:00 DA - 2006/01/04 09:00 DT - 2005/11/26 09:00 YR - 2005 ED - 20060103 RD - 20121115 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16307944 <481. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 16106158 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Breuing KH AU - Warren SM FA - Breuing, Karl H FA - Warren, Stephen M IN - Breuing, Karl H. Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. kbreuing@partners.org TI - Immediate bilateral breast reconstruction with implants and inferolateral AlloDerm slings. SO - Annals of Plastic Surgery. 55(3):232-9, 2005 Sep AS - Ann Plast Surg. 55(3):232-9, 2005 Sep NJ - Annals of plastic surgery VO - 55 IP - 3 PG - 232-9 PI - Journal available in: Print PI - Citation processed from: Print JC - 5vb, 7805336 IO - Ann Plast Surg SB - Index Medicus CP - United States MH - *Breast Implants MH - *Collagen MH - Female MH - Humans MH - *Mammaplasty/mt [Methods] MH - Middle Aged MH - Postoperative Complications AB - To shorten the reconstructive process, improve results, and provide additional options for women seeking mastectomy, we used an acellular cryopreserved dermal matrix (AlloDerm) sling to reestablish the lower pole of the pectoralis major muscle. This technique creates a subpectoral-sub-AlloDerm pocket that completely encloses the breast implant. By tailoring the width of the AlloDerm, we can precisely control the degree of lower-pole fullness. This technique shortens or eliminates the need for tissue expansion and provides an additional option for single-stage breast reconstruction with implants. We have selectively used this technique as a reconstructive option for 10 women undergoing bilateral mastectomy (20 breasts). RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 0148-7043 IL - 0148-7043 PT - Case Reports PT - Journal Article ID - 00000637-200509000-00002 [pii] PP - ppublish LG - English DP - 2005 Sep EZ - 2005/08/18 09:00 DA - 2005/12/15 09:00 DT - 2005/08/18 09:00 YR - 2005 ED - 20051213 RD - 20050817 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16106158 <482. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 15225208 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gillard JA AU - Reed MW AU - Buttle D AU - Cross SS AU - Brown NJ FA - Gillard, Judith A FA - Reed, Malcolm W R FA - Buttle, David FA - Cross, Simon S FA - Brown, Nicola J IN - Gillard, Judith A. Academic Unit of Surgical Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom. TI - Matrix metalloproteinase activity and immunohistochemical profile of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human dermal wound healing. SO - Wound Repair & Regeneration. 12(3):295-304, 2004 May-Jun AS - Wound Repair Regen. 12(3):295-304, 2004 May-Jun NJ - Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society VO - 12 IP - 3 PG - 295-304 PI - Journal available in: Print PI - Citation processed from: Print JC - c81, 9310939 IO - Wound Repair Regen SB - Index Medicus CP - United States MH - Adult MH - Aged MH - Aged, 80 and over MH - Biopsy MH - *Breast/pa [Pathology] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Cicatrix/pa [Pathology] MH - Cicatrix/pp [Physiopathology] MH - Dermis/pa [Pathology] MH - Dermis/ph [Physiology] MH - Extracellular Matrix/pa [Pathology] MH - Extracellular Matrix/ph [Physiology] MH - Female MH - Humans MH - Immunohistochemistry MH - Mastectomy MH - *Matrix Metalloproteinase 2/ph [Physiology] MH - *Matrix Metalloproteinase 9/ph [Physiology] MH - Middle Aged MH - *Tissue Inhibitor of Metalloproteinase-1/ph [Physiology] MH - *Wound Healing/ph [Physiology] AB - Proteolytic activity is required for the turnover of the extracellular matrix during wound healing. Matrix metalloproteinases can collectively cleave all components of the extracellular matrix, with the endogenous tissue inhibitor of metalloproteinase-1 regulating their activity. Breast tissue taken at varying postoperative times (n= 92) or during surgery (controls, n= 17), was used to investigate the temporal and spatial activity of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human wound healing. Matrix metalloproteinase activity, determined using a quenched fluorescence substrate assay, increased during early healing (3-8 weeks) compared to controls, and then decreased between 24 and 36 weeks after surgery (p < 0.05 until 24 weeks, Mann-Whitney U-test). Immunohistochemistry scores for matrix metalloproteinase-9 expression were significantly elevated compared to controls in scar endothelial cells and fibroblasts from 2 until 12 and 20 weeks, respectively. Matrix metalloproteinase-2 staining was observed exclusively in fibroblasts, reaching maximum levels 8-12 weeks after surgery, decreasing by 1.5 years but remaining significantly increased. Tissue inhibitor of metalloproteinase-1 staining was relatively sparse but was significantly increased until 8 weeks after surgery. These results show that matrix metalloproteinases are present at elevated levels during early wound healing, when angiogenesis occurs, and suggest that matrix metalloproteinase-9 may play a significant role. The later expression of matrix metalloproteinase-2 and -9 in fibroblasts suggests a role in extracellular matrix remodeling. RN - 0 (Tissue Inhibitor of Metalloproteinase-1) RN - EC 3-4-24-24 (Matrix Metalloproteinase 2) RN - EC 3-4-24-35 (Matrix Metalloproteinase 9) IS - 1067-1927 IL - 1067-1927 PT - Journal Article PT - Research Support, Non-U.S. Gov't ID - 10.1111/j.1067-1927.2004.012314.x [doi] ID - WRR12314 [pii] PP - ppublish LG - English DP - 2004 May-Jun EZ - 2004/07/01 05:00 DA - 2004/12/16 09:00 DT - 2004/07/01 05:00 YR - 2004 ED - 20041123 RD - 20061115 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=15225208 <483. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 15449446 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Megha T AU - D'Amuri A AU - Benvenuto A AU - De Santi MM AU - De Luca F AU - Civitelli S FA - Megha, T FA - D'Amuri, A FA - Benvenuto, A FA - De Santi, M M FA - De Luca, F FA - Civitelli, S IN - Megha, T. Dipartimento di Patologia Umana e Oncologia, Sezione di Anatomia Patologica, Universita di Siena. TI - [Primary squamous cell carcinoma of the breast: a case report]. [Italian] OT - Carcinoma squamoso primitivo della mammella: descrizione di un caso. SO - Pathologica. 96(2):45-8, 2004 Apr AS - Pathologica. 96(2):45-8, 2004 Apr NJ - Pathologica VO - 96 IP - 2 PG - 45-8 PI - Journal available in: Print PI - Citation processed from: Print JC - ot6, 0401123 IO - Pathologica SB - Index Medicus CP - Italy MH - Adenocarcinoma/di [Diagnosis] MH - Adenocarcinoma/pa [Pathology] MH - Biomarkers, Tumor/an [Analysis] MH - Breast Neoplasms/ch [Chemistry] MH - Breast Neoplasms/di [Diagnosis] MH - *Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Carcinoma, Squamous Cell/ch [Chemistry] MH - Carcinoma, Squamous Cell/di [Diagnosis] MH - *Carcinoma, Squamous Cell/pa [Pathology] MH - Carcinoma, Squamous Cell/su [Surgery] MH - Cell Differentiation MH - Diagnosis, Differential MH - Female MH - Humans MH - Keratins/an [Analysis] MH - Mastectomy, Radical MH - Microscopy, Electron MH - Middle Aged MH - Neoplasm Proteins/an [Analysis] MH - Receptor, ErbB-2/an [Analysis] AB - INTRODUCTION: Primary squamous cell carcinoma (SCC) of the breast is an extremely rare entity and it has a low incidence in comparison with all other mammary cancers. AB - MATERIAL AND METHODS: We describe a case of SCC of the breast in a 55 year old woman who presented with a painless mass located in the external quadrant of the left breast. The neoformation, once removed, was tamponate formalin fixed and routinely processed for inclusion in paraffin. Sections were stained with haematoxilin-eosin and immunohistochemical and electron microscopy investigations were performed. AB - RESULTS: Histologically, the neoplasia was characterized by cystic cavities covered by nests and sheaths of poorly differentiated squamous cells with keratinized areas. Mitotic activity was high, as well as cellular proliferative index, evaluated by Mib-1 (ki 67) antibody. At immunohistochemistry, the tumor cells were diffusely positive for high molecular weight cytokeratins and c-erbB-2, negative for vimentin, estrogen and progesterone. CD68 and LCA were positive only in the inflammatory cells. Electron microscopy confirmed the epithelial nature of the neoplastic cells. A diagnosis of SCC of the breast was made, and a radical mastectomy was performed. AB - CONCLUSIONS: We make a brief review of the literature and discuss the main histologic criteria for the differential diagnosis with adenocarcinoma of the breast with squamous metaplasia. RN - 0 (Biomarkers, Tumor) RN - 0 (Neoplasm Proteins) RN - 68238-35-7 (Keratins) RN - EC 2-7-10-1 (Receptor, ErbB-2) IS - 0031-2983 IL - 0031-2983 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Italian DP - 2004 Apr EZ - 2004/09/29 05:00 DA - 2004/10/30 09:00 DT - 2004/09/29 05:00 YR - 2004 ED - 20041029 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=15449446 <484. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 15468424 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cothren CC AU - Gallego K AU - Anderson ED AU - Schmidt D FA - Cothren, C Clay FA - Gallego, Kelly FA - Anderson, Erica D FA - Schmidt, Douglas TI - Chest wall reconstruction with acellular dermal matrix (AlloDerm) and a latissimus muscle flap. SO - Plastic & Reconstructive Surgery. 114(4):1015-7, 2004 Sep 15 AS - Plast Reconstr Surg. 114(4):1015-7, 2004 Sep 15 NJ - Plastic and reconstructive surgery VO - 114 IP - 4 PG - 1015-7 PI - Journal available in: Print PI - Citation processed from: Print JC - 1306050, p9s IO - Plast. Reconstr. Surg. SB - Core Clinical Journals (AIM) SB - Index Medicus CP - United States MH - *Breast Neoplasms/su [Surgery] MH - *Carcinoma, Ductal/su [Surgery] MH - *Collagen MH - Female MH - Follow-Up Studies MH - Humans MH - *Mastectomy, Segmental MH - Middle Aged MH - *Neoplasm Recurrence, Local/su [Surgery] MH - *Neoplasms, Second Primary/su [Surgery] MH - *Postoperative Complications/su [Surgery] MH - *Prosthesis Implantation MH - *Sarcoma/su [Surgery] MH - *Surgical Flaps MH - Suture Techniques MH - *Thoracic Wall/su [Surgery] RN - 0 (Alloderm) RN - 9007-34-5 (Collagen) IS - 0032-1052 IL - 0032-1052 PT - Case Reports PT - Letter PP - ppublish LG - English DP - 2004 Sep 15 EZ - 2004/10/07 09:00 DA - 2004/10/23 09:00 DT - 2004/10/07 09:00 YR - 2004 ED - 20041022 RD - 20150624 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=15468424 <485. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 15222111 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Saito Y AU - Amano S AU - Kashio M AU - Abe H AU - Kuboi Y AU - Sakurai K AU - Aoki N AU - Hata S AU - Negishi N FA - Saito, Yoshihito FA - Amano, Sadao FA - Kashio, Mitsuhiko FA - Abe, Hideo FA - Kuboi, Youichi FA - Sakurai, Kenichi FA - Aoki, Nobuhiko FA - Hata, Satoshi FA - Negishi, Nanao IN - Saito, Yoshihito. Dept. of Breast and Endocrine Surgery, Nihon University School of Medicine. TI - [A case of breast cancer with multiple bone metastases demonstrating complete remission with high-dose toremifene therapy]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 31(6):911-4, 2004 Jun AS - Gan To Kagaku Ryoho. 31(6):911-4, 2004 Jun NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 31 IP - 6 PG - 911-4 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Antineoplastic Agents, Hormonal/ad [Administration & Dosage] MH - *Bone Neoplasms/sc [Secondary] MH - *Breast Neoplasms/dt [Drug Therapy] MH - *Breast Neoplasms/pa [Pathology] MH - *Carcinoma, Ductal, Breast/dt [Drug Therapy] MH - *Carcinoma, Ductal, Breast/sc [Secondary] MH - Chemotherapy, Adjuvant MH - Dose-Response Relationship, Drug MH - Drug Administration Schedule MH - Female MH - Humans MH - Mastectomy MH - Middle Aged MH - Remission Induction MH - *Toremifene/ad [Administration & Dosage] AB - We report a 64-year-old woman who underwent mastectomy for stage II (T2N1M0) advanced breast cancer, in whom multiple spine metastases developed 18 months postoperatively. She received 6 cycles of CA (cyclophosphamide 500 mg/m2, ADM 50 mg/m2 3 wq) therapy and oral tamoxifen (20 mg/body) administration for adjuvant therapy. The multiple bone metastases of the spine were revealed by technetium bone scan. The level of serum tumor marker CA15-3 increased two times over the normal range 18 months after surgery. She also developed osteoporosis a few years later, so we selected high-dose toremifene administration (120 mg/body) as a second-line therapy. No adverse effects have occurred and bone metastases disappeared. Moreover, the tumor marker was also normalized 6 months after toremifene therapy started. It was shown that high-dose treatment of toremifene was useful for recurrent breast cancer with bone metastasis. RN - 0 (Antineoplastic Agents, Hormonal) RN - 7NFE54O27T (Toremifene) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2004 Jun EZ - 2004/06/30 05:00 DA - 2004/07/09 05:00 DT - 2004/06/30 05:00 YR - 2004 ED - 20040708 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=15222111 <486. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 12744090 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Gioffre Florio MA AU - Fama F AU - Giacobbe G AU - Pollicino A AU - Scarfo P FA - Gioffre Florio, Maria Antonietta FA - Fama, Fausto FA - Giacobbe, Giuseppa FA - Pollicino, Andrea FA - Scarfo, Paola IN - Gioffre Florio, Maria Antonietta. Universita degli Studi di Messina. TI - [Surgical treatment of breast cancer after neoadjuvant therapy]. [Italian] OT - La chirurgia del cancro della mammella dopo terapia neoadiuvante. SO - Chirurgia Italiana. 55(2):173-8, 2003 Mar-Apr AS - Chir Ital. 55(2):173-8, 2003 Mar-Apr NJ - Chirurgia italiana VO - 55 IP - 2 PG - 173-8 PI - Journal available in: Print PI - Citation processed from: Print JC - czz, 0151753 IO - Chir Ital SB - Index Medicus CP - Italy MH - Adult MH - Aged MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - Breast Neoplasms/dg [Diagnostic Imaging] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/px [Psychology] MH - *Breast Neoplasms/su [Surgery] MH - Female MH - Humans MH - *Mastectomy, Segmental MH - Middle Aged MH - *Neoadjuvant Therapy/mt [Methods] MH - Quality of Life MH - Retrospective Studies MH - Treatment Outcome MH - Ultrasonography AB - Primary chemotherapy represents a new therapeutic strategy that allows the implementation of conservative surgical treatment in locally advanced breast cancer or in cancers measuring > 3 cm. Of 127 patients with breast cancers measuring > 2.5 cm, 86 were treated with primary chemotherapy. This consisted in the administration of the ADM + TAX protocol in 28 cases and CNF in 58 cases. Three complete responses, 8 cases of stable disease and 75 partial responses were observed. Eleven radical mastectomies and 74 conservative treatments were performed. The chemotherapy protocol enabled us to convert 87% of the patients treated to conservative treatment, thus affording a treatment that offers a better quality of life despite the existence of a voluminous cancer and is of considerable psychological help in patients suffering from cancer of the breast. IS - 0009-4773 IL - 0009-4773 PT - Journal Article PP - ppublish LG - Italian DP - 2003 Mar-Apr EZ - 2003/05/15 05:00 DA - 2003/06/19 05:00 DT - 2003/05/15 05:00 YR - 2003 ED - 20030618 RD - 20161124 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12744090 <487. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 12610876 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Sawada M AU - Ono Y AU - Fukushima M FA - Sawada, Mitsuhiro FA - Ono, Yuichi FA - Fukushima, Matsuro IN - Sawada, Mitsuhiro. Dept. of Surgery, Hirosaki Central Hospital. TI - [A case of advanced recurrent breast cancer responding to treatment with weekly docetaxel combined with doxorubicin]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 30(2):259-62, 2003 Feb AS - Gan To Kagaku Ryoho. 30(2):259-62, 2003 Feb NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 30 IP - 2 PG - 259-62 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - *Carcinoma, Ductal, Breast/dt [Drug Therapy] MH - Carcinoma, Ductal, Breast/sc [Secondary] MH - Carcinoma, Ductal, Breast/su [Surgery] MH - Combined Modality Therapy MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - Floxuridine/ad [Administration & Dosage] MH - Humans MH - Lung Neoplasms/sc [Secondary] MH - Lymphatic Metastasis MH - Mastectomy, Modified Radical MH - Medroxyprogesterone Acetate/ad [Administration & Dosage] MH - Middle Aged MH - Paclitaxel/ad [Administration & Dosage] MH - *Paclitaxel/aa [Analogs & Derivatives] MH - Skin Neoplasms/sc [Secondary] MH - *Taxoids AB - The patient was a 60-year-old women who had undergone left modified radical mastectomy on April 7, 1999, and was treated with chemo- and hormonal therapy of UFT and TAM. Two years and 6 months later, she showed multiple lung metastases. Because 5'-DFUR + MPA therapy was not effective, weekly docetaxel (TXT) + adriamycin (ADM) was carried out, and definite improvement in the lung and lymph nodes metastases was observed. It is suggested that this combination therapy may be useful for advanced recurrent breast cancer patients with multiple lung metastases. RN - 0 (Taxoids) RN - 039LU44I5M (Floxuridine) RN - 15H5577CQD (docetaxel) RN - 80168379AG (Doxorubicin) RN - C2QI4IOI2G (Medroxyprogesterone Acetate) RN - P88XT4IS4D (Paclitaxel) RN - V1JK16Y2JP (doxifluridine) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2003 Feb EZ - 2003/03/04 04:00 DA - 2003/03/11 04:00 DT - 2003/03/04 04:00 YR - 2003 ED - 20030310 RD - 20151123 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12610876 <488. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 12610875 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Koga Y AU - Ohchi T AU - Kudo S AU - Ogata K AU - Nakamura T AU - Ishiodori H AU - Ochiai T AU - Muranaka T AU - Ishihara A FA - Koga, Yoshikatsu FA - Ohchi, Tetsufumi FA - Kudo, Shunsuke FA - Ogata, Kenichi FA - Nakamura, Takeshi FA - Ishiodori, Hiroyuki FA - Ochiai, Takashi FA - Muranaka, Takahiro FA - Ishihara, Akira IN - Koga, Yoshikatsu. Dept. of Surgery, Miyazaki Prefectural Nobeoka Hospital. TI - [Effective transarterial neoadjuvant chemotherapy with paclitaxel (TXL) in a case of locally advanced breast cancer]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 30(2):255-8, 2003 Feb AS - Gan To Kagaku Ryoho. 30(2):255-8, 2003 Feb NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 30 IP - 2 PG - 255-8 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Antineoplastic Agents, Phytogenic/ad [Administration & Dosage] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/su [Surgery] MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - Humans MH - Infusions, Intra-Arterial MH - Mastectomy, Radical MH - Middle Aged MH - Neoadjuvant Therapy MH - *Paclitaxel/ad [Administration & Dosage] MH - Subclavian Artery MH - Thoracic Arteries AB - The patient was a 49-year-old woman who had locally advanced breast cancer with skin invasion. She was placed on neoadjuvant weekly systemic chemotherapy of TXL (65 mg/m2) and ADM (20 mg/m2). After systemic chemotherapy, she underwent 2 courses of transarterial neoadjuvant chemotherapy of TXL (day 1, 8, 15). We administered TXL (45 mg/m2) into the subclavian artery and TXL (20 mg/m2) into the internal thoracic artery. Although she experienced grade 3 leukopenia during systemic chemotherapy, she experienced only grade 2 alopecia and grade 1 nausea during transarterial chemotherapy. After chemotherapy, she underwent radical mastectomy. We report herein a case in which transarterial neoadjuvant chemotherapy with TXL was effective. RN - 0 (Antineoplastic Agents, Phytogenic) RN - 80168379AG (Doxorubicin) RN - P88XT4IS4D (Paclitaxel) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2003 Feb EZ - 2003/03/04 04:00 DA - 2003/03/11 04:00 DT - 2003/03/04 04:00 YR - 2003 ED - 20030310 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12610875 <489. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 12484084 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Hasegawa S AU - Yamamoto Y AU - Ishiwa N AU - Yoshikawa T AU - Morinaga S AU - Noguchi Y AU - Matsumoto A AU - Nishimura J AU - Okoshi T FA - Hasegawa, Shinichi FA - Yamamoto, Yuji FA - Ishiwa, Naoki FA - Yoshikawa, Takaki FA - Morinaga, Soichirou FA - Noguchi, Yoshikazu FA - Matsumoto, Akihiko FA - Nishimura, Junichi FA - Okoshi, Takafumi IN - Hasegawa, Shinichi. Dept. of Surgery, Kowan Hospital. TI - [Recurrence of right breast cancer at the thoracic wall successfully treated with intra-arterial infusion of doxorubicin hydrochloride--a case report]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 29(12):2399-401, 2002 Nov AS - Gan To Kagaku Ryoho. 29(12):2399-401, 2002 Nov NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 29 IP - 12 PG - 2399-401 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - *Antineoplastic Agents/ad [Administration & Dosage] MH - Antineoplastic Combined Chemotherapy Protocols/ad [Administration & Dosage] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/su [Surgery] MH - Cyclophosphamide/ad [Administration & Dosage] MH - *Doxorubicin/ad [Administration & Dosage] MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - *Infusions, Intra-Arterial MH - Injections, Intra-Arterial MH - Mastectomy MH - Neoplasm Recurrence, Local MH - Thoracic Neoplasms/dt [Drug Therapy] AB - We report a recurrent case of breast cancer successfully treated with intra-arterial infusion of doxorubicin hydrochloride (ADM) combined with systemic CAF therapy. The patient, a 37-year-old woman, was diagnosed with a recurrence at the thoracic wall 55 months after curative resection for right breast cancer. She was treated with intra-arterial infusion chemotherapy of ADM, 30 mg, combined with systemic CAF therapy of cyclophosphamide, 100 mg from days 1 to 14, ADM, 30 mg on days 1 and 8, and 5-fluorouracil, 500 mg on days 1 and 8, as one course. Two courses of the treatment resulted in a complete response of the tumor. This result suggests that local and systemic chemotherapy could be effective for the treatment of local recurrence of breast cancer. RN - 0 (Antineoplastic Agents) RN - 80168379AG (Doxorubicin) RN - 8N3DW7272P (Cyclophosphamide) RN - U3P01618RT (Fluorouracil) PS - CAF protocol IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2002 Nov EZ - 2002/12/18 04:00 DA - 2003/01/15 04:00 DT - 2002/12/18 04:00 YR - 2002 ED - 20030114 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12484084 <490. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 12404900 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cammisuli F AU - Catania V AU - Santuccio A AU - Mirone I AU - Pagano P AU - Cavallaro A FA - Cammisuli, F FA - Catania, V FA - Santuccio, A FA - Mirone, I FA - Pagano, P FA - Cavallaro, A IN - Cammisuli, F. Cattedra di Chirurgia Oncologica, Universita di Catania. TI - [Breast carcinoma in pregnancy: a clinical case]. [Italian] OT - Carcinoma della mammella in gravidanza: caso clinico. SO - Annali Italiani di Chirurgia. 73(3):317-21, 2002 May-Jun AS - Ann Ital Chir. 73(3):317-21, 2002 May-Jun NJ - Annali italiani di chirurgia VO - 73 IP - 3 PG - 317-21 PI - Journal available in: Print PI - Citation processed from: Print JC - 5c0, 0372343 IO - Ann Ital Chir SB - Index Medicus CP - Italy MH - Adult MH - *Breast Neoplasms/th [Therapy] MH - *Carcinoma, Ductal, Breast/th [Therapy] MH - Combined Modality Therapy MH - Female MH - Humans MH - Pregnancy MH - *Pregnancy Complications, Neoplastic/th [Therapy] AB - Breast cancer is a rare, but frequently hidden pathology. A woman, 36 years old, during the early months of pregnancy found a little tumor in her right breast. A fine needle biopsy was negative for cancer. Despite this, the tumor rose and two months after delivery (the patient breast-fed her daughter for a month), she had pain in the right axillary region and the tumors involved all superior dials of the right breast. A Madden mastectomy was performed. The histopathological report was: ductal invasive breast cancer 3 of 19 lymph nodes involved, stage IIIA, TNM pT3N2M0, ER -, PgR +--. Chemotherapeutic regimens were: at first ADM 75 mg/m2 for 5 cycles, and after CMF 1-8 for 6 cycles. After six months the woman had a cutaneous recurrence in the scar of mastectomy, treated with surgery and RT. Thirteen months after, she had lung MTS and then brain MTS. The patient died thirty months after the mastectomy. The surgeons have to discover the women high-risk for the breast cancer before and during the pregnancy. Excisional biopsy is the diagnostic procedure of choice for breast lump during pregnancy. When a breast cancer develops during a pregnancy, the surgeon has to operate immediately the tumors. Chemotherapeutic regimens should be delayed until the second o third trimester or after delivery. IS - 0003-469X IL - 0003-469X PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Italian DP - 2002 May-Jun EZ - 2002/10/31 04:00 DA - 2002/12/31 04:00 DT - 2002/10/31 04:00 YR - 2002 ED - 20021230 RD - 20061115 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12404900 <491. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 12465425 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Akin J FA - Akin, Judy TI - Office education: sharing your knowledge. SO - Plastic Surgical Nursing. 22(3):157-60, 2002 AS - Plast Surg Nurs. 22(3):157-60, 2002 NJ - Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses VO - 22 IP - 3 PG - 157-60 PI - Journal available in: Print PI - Citation processed from: Print JC - 8403490, p8m IO - Plast Surg Nurs SB - Nursing Journal CP - United States MH - Breast Implantation/nu [Nursing] MH - *Breast Implantation MH - Humans MH - *Patient Education as Topic MH - Postoperative Care MH - Preoperative Care MH - United States AB - The author's passion for plastic surgery nursing emerged from a life-changing experience involving skin grafting and skin reconstruction on her face from basal cell carcinoma. After many more skin cancer excisions, she decided to leave the hospital environment to pursue further study and work in the field of dermatology and wound care. This helped to expand her specialized knowledge of skin anatomy/physiology and prepare for a career in plastic/reconstructive surgery. During her masters degree program, the author developed educational guidelines and materials to facilitate her new role in plastic surgery as a nurse/patient/community educator. She finished her masters degree in nursing education and completed her clinical preceptor/internship with two board certified plastic and reconstructive surgeons in December of 2000. IS - 0741-5206 IL - 0741-5206 PT - Journal Article PP - ppublish LG - English DP - 2002 EZ - 2002/12/06 04:00 DA - 2002/12/28 04:00 DT - 2002/12/06 04:00 YR - 2002 ED - 20021227 RD - 20071115 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=12465425 <492. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 11865641 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Otsuka T AU - Terashima Y AU - Tashiro S FA - Otsuka, Toshihiro FA - Terashima, Yoshiyasu FA - Tashiro, Seiki IN - Otsuka, Toshihiro. First Dept. of Surgery, Tokushima University School of Medicine. TI - [A case of long surviving advanced recurrent breast cancer with multiple bone metastases responding to treatment with 5'-DFUR combined with MPA]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 29(2):313-6, 2002 Feb AS - Gan To Kagaku Ryoho. 29(2):313-6, 2002 Feb NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 29 IP - 2 PG - 313-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Adenocarcinoma, Scirrhous/dt [Drug Therapy] MH - *Adenocarcinoma, Scirrhous/sc [Secondary] MH - Adenocarcinoma, Scirrhous/su [Surgery] MH - Aged MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Bone Neoplasms/dt [Drug Therapy] MH - *Bone Neoplasms/sc [Secondary] MH - *Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Drug Administration Schedule MH - Female MH - Floxuridine/ad [Administration & Dosage] MH - Humans MH - Mastectomy, Radical MH - Medroxyprogesterone/ad [Administration & Dosage] MH - Survivors AB - The patient was a 69-year-old woman who had undergone right standard radical mastectomy on August 8, 1991, and was treated with chemo- and hormonal therapy of ADM, UFT and TMA. Three years later she showed multiple bone metastases with elevation of CEA, and 5'-DFUR 1,200 mg/day and MPA 800 mg/day were administered. Two years later her CEA levels were decreased, 5'-DFUR was discontinued and MPA 1,200 mg/day only was continued. Two months later a side effect of MPA, her body weight gain, was observed, and the dosage of MPA was reduced from 1,200 mg/day to 800 mg/day. Then the side effect was resolved. Bone scintigraphy and MRI showed that bone metastatic lesions were reduced 6 years after 5'-DFUR and MPA therapy. It is suggested that this combination therapy may be useful for advanced recurrent breast cancer patients with multiple bone metastases. RN - 039LU44I5M (Floxuridine) RN - HSU1C9YRES (Medroxyprogesterone) RN - V1JK16Y2JP (doxifluridine) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2002 Feb EZ - 2002/02/28 10:00 DA - 2002/03/07 10:01 DT - 2002/02/28 10:00 YR - 2002 ED - 20020305 RD - 20151123 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11865641 <493. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 11712345 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Matsuo K AU - Honda O AU - Hiraga K FA - Matsuo, K FA - Honda, O FA - Hiraga, K IN - Matsuo, K. Department of Anesthesiology, Department of Surgical Oncology, National Cancer Center Hospital, Tokyo 104-0045. TI - [Cardiac conduction abnormalities after neoadjuvant chemotherapy with doxorubicin and docetaxel for primary breast carcinoma: a case report]. [Japanese] SO - Masui - Japanese Journal of Anesthesiology. 50(10):1113-5, 2001 Oct AS - Masui. 50(10):1113-5, 2001 Oct NJ - Masui. The Japanese journal of anesthesiology VO - 50 IP - 10 PG - 1113-5 PI - Journal available in: Print PI - Citation processed from: Print JC - khr, 0413707 IO - Masui SB - Index Medicus CP - Japan MH - Aged MH - *Anesthesia/ae [Adverse Effects] MH - *Antineoplastic Combined Chemotherapy Protocols/ae [Adverse Effects] MH - Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/th [Therapy] MH - Chemotherapy, Adjuvant MH - Doxorubicin/ad [Administration & Dosage] MH - Doxorubicin/ae [Adverse Effects] MH - Female MH - *Heart Block/et [Etiology] MH - Humans MH - *Intraoperative Complications/et [Etiology] MH - Mastectomy, Segmental MH - Paclitaxel/ad [Administration & Dosage] MH - Paclitaxel/ae [Adverse Effects] MH - *Paclitaxel/aa [Analogs & Derivatives] MH - *Postoperative Complications/et [Etiology] MH - *Taxoids AB - A 65-year-old woman with primary breast carcinoma (T 3 N 0 M 0) received neoadjuvant chemotherapy consisting of 4 cycles of 50 mg.m-2 doxorubicin (ADM) and 60 mg.m-2 docetaxel (TXT). The patient received 50 mg.m-2 ADM and 60 mg.m-2 TXT intravenously on day 1 of each cycle every three weeks. The patient underwent transthoracic echocardiography and electrocardiography (ECG) before surgery and these results were normal. ECG showed bigeminy, trigeminy after intubation and incomplete AV block (Mobitz type II) during and after surgery. The patient recovered from these arrhythmias on the first postoperative day. Our data indicate one possibility that the management of anesthetic condition might easily induce the cardiac conduction abnormalities of this patient using ADM as neoadjuvant chemotherapy. RN - 0 (Taxoids) RN - 15H5577CQD (docetaxel) RN - 80168379AG (Doxorubicin) RN - P88XT4IS4D (Paclitaxel) IS - 0021-4892 IL - 0021-4892 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2001 Oct EZ - 2001/11/20 10:00 DA - 2002/01/05 10:01 DT - 2001/11/20 10:00 YR - 2001 ED - 20011228 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11712345 <494. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 10700906 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fujitomi Y AU - Fujiyoshi K AU - Yasue K FA - Fujitomi, Y FA - Fujiyoshi, K FA - Yasue, K IN - Fujitomi, Y. Dept. of Surgery, Oita Ken Koseiren Tsurumi Hospital. TI - [Improved QOL with cancer chemotherapy in two patients with breast cancer suffering form carcinomatous pleurisy and carcinomatous peritonitis]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 27(2):303-6, 2000 Feb AS - Gan To Kagaku Ryoho. 27(2):303-6, 2000 Feb NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 27 IP - 2 PG - 303-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/px [Psychology] MH - Cyclophosphamide/ad [Administration & Dosage] MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - Medroxyprogesterone Acetate/ad [Administration & Dosage] MH - Middle Aged MH - *Peritonitis/dt [Drug Therapy] MH - *Pleurisy/dt [Drug Therapy] MH - *Quality of Life MH - Tegafur/ad [Administration & Dosage] MH - Uracil/ad [Administration & Dosage] AB - One of the breast cancer patients introduced here suffered from recurrent carcinomatous pleurisy and the other from recurrent carcinomatous peritonitis. The patient with recurrent carcinomatous pleurisy was a 47-year-old female with stage IIIa breast cancer. She underwent a standard mastectomy and, following surgery, radiotherapy (50 Gy) and CAF therapy (30 mg of ADM, 1,800 mg of futraful and 100 mg of CPA, administered p.o.). Dyspnea occurred 4 years after surgery. Pleural exudate cytodiagnosis proved positive and the patient was diagnosed with carcinomatous peritonitis. Continuous thoracic cavity drainage was carried out, and 30 mg of ADM was injected into the thoracic cavity. CAF therapy was performed. The dyspnea and thoracic effusion disappeared. At present, after one year and 7 months, the patient is receiving outpatient treatment and remains under observation. The patient with recurrent carcinomatous pleurisy was a 43-year-old female. The breast cancer was detected in a diagnosis of metastasis to the axillary lymph nodes. An increased CA15-3 level and ascitic retention were observed postoperatively at 5 months. Following administration of 600 mg of UFT and 1,200 mg of MPA, the ascites decreased and improvement of the thickened peritoneum was noted. The CA15-3 level was also lowered. It is anticipated that chemotherapy for carcinomatous pleurisy and carcinomatous peritonitis will contribute to an improvement in patients' QOL. RN - 1548R74NSZ (Tegafur) RN - 56HH86ZVCT (Uracil) RN - 80168379AG (Doxorubicin) RN - 8N3DW7272P (Cyclophosphamide) RN - C2QI4IOI2G (Medroxyprogesterone Acetate) RN - U3P01618RT (Fluorouracil) PS - 1-UFT protocol; CAF protocol IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 2000 Feb EZ - 2000/03/04 09:00 DA - 2000/03/11 09:00 DT - 2000/03/04 09:00 YR - 2000 ED - 20000308 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=10700906 <495. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 10483138 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Uno H AU - Fujita M AU - Hino N AU - Nakagawa H AU - Miyagawa H AU - Aoki J AU - Taniyama K AU - Sasaki N FA - Uno, H FA - Fujita, M FA - Hino, N FA - Nakagawa, H FA - Miyagawa, H FA - Aoki, J FA - Taniyama, K FA - Sasaki, N IN - Uno, H. Department of Internal Medicine, Kure Kyosai Hospital, Japan. TI - [High-dose chemotherapy with autologous peripheral blood stem cell transplantation support in a patient with breast cancer metastasis to bone marrow: immunocytochemical monitoring of cancer-cell contamination]. [Japanese] SO - Rinsho Ketsueki - Japanese Journal of Clinical Hematology. 40(7):556-62, 1999 Jul AS - Rinsho Ketsueki. 40(7):556-62, 1999 Jul NJ - [Rinsho ketsueki] The Japanese journal of clinical hematology VO - 40 IP - 7 PG - 556-62 PI - Journal available in: Print PI - Citation processed from: Print JC - kii, 2984782r IO - Rinsho Ketsueki SB - Index Medicus CP - Japan MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/ad [Administration & Dosage] MH - *Bone Marrow Neoplasms/sc [Secondary] MH - *Bone Marrow Neoplasms/th [Therapy] MH - *Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/th [Therapy] MH - *Carcinoma, Ductal, Breast/sc [Secondary] MH - *Carcinoma, Ductal, Breast/th [Therapy] MH - Cisplatin/ad [Administration & Dosage] MH - Combined Modality Therapy MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - *Hematopoietic Stem Cell Transplantation MH - Humans MH - Immunohistochemistry MH - Methotrexate/ad [Administration & Dosage] MH - *Transplantation, Autologous MH - Vinblastine/ad [Administration & Dosage] AB - A 32-year-old woman who 1 year earlier underwent a right mastectomy for stage II breast cancer with the histology of invasive ductal carcinoma (scirrhus type) was admitted due to recurrent, metastatic breast cancer in January 1997. She presented multiple metastatic lesions in the skin, lymph nodes, bone, lungs, liver, and spleen, and her bone marrow was replaced almost entirely by tumor cells. The patient was sequentially treated with 5 courses of cyclophosphamide (CPA) and adriamycin (ADM) (CA); 2 courses of CPA, ADM, and 5-fluorouracil; 5 caurses of docetaxel hydrate; and 1 course of CA. After recovery of the normal bone marrow by standard-dose chemotherapies, peripheral blood stem cells (PBSC) were then collected after mobilization with G-CSF. The number of breast cancer cells in bone marrow and PBSC samples was determined by immunocytochemical staining with an anti-cytokeratin monoclonal antibody. The number of tumor cells in PBSC sample was within the level for non-metastatic breast cancer. Complete remission was obtained with high-dose chemotherapy consisting of CPA and Thio-TEPA, and supported by autologous PBSC transplantation. RN - 5V9KLZ54CY (Vinblastine) RN - 80168379AG (Doxorubicin) RN - Q20Q21Q62J (Cisplatin) RN - YL5FZ2Y5U1 (Methotrexate) PS - M-VAC protocol IS - 0485-1439 IL - 0485-1439 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1999 Jul EZ - 1999/09/14 DA - 1999/09/14 00:01 DT - 1999/09/14 00:00 YR - 1999 ED - 19990922 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=10483138 <496. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 10431584 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kusama M AU - Kaise H AU - Nakayama S AU - Ohta D AU - Aoki T AU - Koyanagi Y FA - Kusama, M FA - Kaise, H FA - Nakayama, S FA - Ohta, D FA - Aoki, T FA - Koyanagi, Y IN - Kusama, M. Third Dept. of Surgery, Tokyo Medical University. TI - [A case of breast cancer patient of CAF (cyclophosphamide, adriamycin, 5-fluorouracil) resistant lung metastasis with remarkable response to reverse drug-resistance by toremifene]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 26(8):1171-5, 1999 Jul AS - Gan To Kagaku Ryoho. 26(8):1171-5, 1999 Jul NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 26 IP - 8 PG - 1171-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/ad [Administration & Dosage] MH - *Breast Neoplasms/pa [Pathology] MH - Chemotherapy, Adjuvant MH - Cyclophosphamide/ad [Administration & Dosage] MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Resistance, Neoplasm MH - *Estrogen Antagonists/ad [Administration & Dosage] MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - *Lung Neoplasms/dt [Drug Therapy] MH - *Lung Neoplasms/sc [Secondary] MH - Mastectomy MH - *Toremifene/ad [Administration & Dosage] AB - A 43-year-old female underwent muscle preserving mastectomy with 6 cycles of adjuvant CMF chemotherapy for breast cancer. She developed multiple lung metastases 16 months later. The metastases were refractory to 3 cycles of CAF administration, and worsened (PD). We therefore added high-dose toremifene to her treatment. This combination therapy brought a marked decrease in the lung metastases. After 9 cycles of CAF with high-dose toremifene therapy, lung metastatic findings had almost disappeared from her chest X-ray. Following this treatment, UFT and toremifene were orally administered for maintenance therapy. Thirty-two months later at present, no increase in these lesions has been observed. High-dose antiestrogen drugs have the potential to inhibit P-glycoprotein. The combination of high-dose toremifene with CAF is potentially effective against ADM-resistant breast cancer. RN - 0 (Estrogen Antagonists) RN - 7NFE54O27T (Toremifene) RN - 80168379AG (Doxorubicin) RN - 8N3DW7272P (Cyclophosphamide) RN - U3P01618RT (Fluorouracil) PS - CAF protocol IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1999 Jul EZ - 1999/08/04 DA - 1999/08/04 00:01 DT - 1999/08/04 00:00 YR - 1999 ED - 19990827 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=10431584 <497. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 9838917 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kihara M AU - Matsusaka K AU - Miyauchi A AU - Maeda M FA - Kihara, M FA - Matsusaka, K FA - Miyauchi, A FA - Maeda, M IN - Kihara, M. Second Dept. of Surgery, Kagawa Medical University. TI - [A case of stage IV breast cancer showing long-term complete response to combination therapy with 5'-DFUR and MPA]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 25(13):2123-6, 1998 Nov AS - Gan To Kagaku Ryoho. 25(13):2123-6, 1998 Nov NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 25 IP - 13 PG - 2123-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Adenocarcinoma, Scirrhous/dt [Drug Therapy] MH - Adenocarcinoma, Scirrhous/sc [Secondary] MH - Adenocarcinoma, Scirrhous/su [Surgery] MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - Bone Neoplasms/sc [Secondary] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Combined Modality Therapy MH - Female MH - Floxuridine/ad [Administration & Dosage] MH - Humans MH - Lymphatic Metastasis MH - Mastectomy MH - Medroxyprogesterone Acetate/ad [Administration & Dosage] MH - Middle Aged MH - Remission Induction AB - We report a 62-year-old woman with supraclavicular lymph node, pleural and bone metastases from breast cancer showing a long-term complete response to combination therapy with 5'-DFUR and MPA. A large amount of pleural effusion was drained followed by administration of ADM, which improved the amount of effusion. Treatment with CAF and TAM decreased tumor size, but CAF was abandoned due to severe leukopenia. Mastectomy was performed for local control. However, levels of tumor markers increased progressively. Administration of CMF was tried, but tumor markers continued to increase. Therefore, combined chemoendocrine therapy with 5'-DFUR and MPA was undertaken. Levels of tumor markers normalized and a complete response was obtained 13 months after starting this combination therapy. There are no further metastatic lesions evident, and this status has been consistently maintained for more than three years (six years and five months after diagnosis of breast cancer). There were no significant side effects of this combination therapy except for mild weight gain and moon face. This combination regimen with 5'-DFUR and MPA is considered useful as a second-line treatment for advanced breast cancer. RN - 039LU44I5M (Floxuridine) RN - C2QI4IOI2G (Medroxyprogesterone Acetate) RN - V1JK16Y2JP (doxifluridine) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1998 Nov EZ - 1998/12/05 DA - 1998/12/05 00:01 DT - 1998/12/05 00:00 YR - 1998 ED - 19981210 RD - 20151123 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=9838917 <498. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 9456357 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Personelle J AU - Bolivar de Souza Pinto E AU - Ruiz RO FA - Personelle, J FA - Bolivar de Souza Pinto, E FA - Ruiz, R O TI - Injection of vitamin A acid, vitamin E, and vitamin C for treatment of tissue necrosis. SO - Aesthetic Plastic Surgery. 22(1):58-64, 1998 Jan-Feb AS - Aesthetic Plast Surg. 22(1):58-64, 1998 Jan-Feb NJ - Aesthetic plastic surgery VO - 22 IP - 1 PG - 58-64 PI - Journal available in: Print PI - Citation processed from: Print JC - 2wn, 7701756 IO - Aesthetic Plast Surg SB - Index Medicus CP - United States MH - Adolescent MH - Adult MH - Aged MH - Animals MH - *Antioxidants/ad [Administration & Dosage] MH - *Ascorbic Acid/ad [Administration & Dosage] MH - Gangrene/dt [Drug Therapy] MH - Humans MH - Injections, Intradermal MH - Male MH - Middle Aged MH - Rats MH - *Skin Diseases/dt [Drug Therapy] MH - *Skin Diseases/pa [Pathology] MH - *Vitamin A/ad [Administration & Dosage] MH - *Vitamin E/ad [Administration & Dosage] AB - Experimental studies concerning All-Trans Retinoic acid 0.1% with the antioxidant action of the Vitamin E (tocopherol acetate 0.20%) and Vitamin C (coated ascorbic acid 0.20%) efficacy in both the vascular neoformation induction and cellular membrane stabilization have been conducted by us to improve skin necrosis regression after routine plastic surgeries. Patients after rhytidectomy, breast reduction, and abdominoplasty with localized skin flap necrosis, were submitted to daily intradermic injections for a period of 15 days and had their skin healed by the effects of these vitamins. RN - 0 (Antioxidants) RN - 11103-57-4 (Vitamin A) RN - 1406-18-4 (Vitamin E) RN - PQ6CK8PD0R (Ascorbic Acid) IS - 0364-216X IL - 0364-216X PT - Journal Article PP - ppublish LG - English DP - 1998 Jan-Feb EZ - 1998/05/09 DA - 1998/05/09 00:01 DT - 1998/05/09 00:00 YR - 1998 ED - 19980504 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=9456357 <499. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 9043277 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Wysocki AB FA - Wysocki, A B IN - Wysocki, A B. Department of Nursing, New York University Medical Center, NY 10016, USA. TI - Wound fluids and the pathogenesis of chronic wounds. SO - Journal of Wound, Ostomy, & Continence Nursing. 23(6):283-90, 1996 Nov AS - J Wound Ostomy Continence Nurs. 23(6):283-90, 1996 Nov NJ - Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society VO - 23 IP - 6 PG - 283-90 PI - Journal available in: Print PI - Citation processed from: Print JC - bv2, 9435679 IO - J Wound Ostomy Continence Nurs SB - Nursing Journal CP - United States MH - Acute Disease MH - Adult MH - Aged MH - Chronic Disease MH - *Collagenases/ph [Physiology] MH - *Exudates and Transudates/ch [Chemistry] MH - Female MH - *Fibronectins/ph [Physiology] MH - Humans MH - Male MH - *Matrix Metalloproteinase 3/ph [Physiology] MH - Matrix Metalloproteinase 9 MH - Middle Aged MH - *Wound Healing MH - Wounds and Injuries/en [Enzymology] MH - *Wounds and Injuries/pp [Physiopathology] AB - PURPOSE: To describe two areas of ongoing investigation into analysis of wound fluids that may eventually lead to better understanding of pathophysiology of chronic wounds and to improved care and treatment. AB - METHODS: Studies used Lowry protein assay, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western blotting, and zymography to analyze fluids from acute and chronic wounds and serum samples collected from healthy and affected volunteers. AB - SUBJECTS: Thirty-one subjects with ages ranging from 32 to 79 years participated in the research; fluid was collected from chronic wounds in 10 patients (two female, four male, and four unrecorded), fluid was collected from acute mastectomy wounds in 15 patients (all female); blister fluid and blood were collected from two volunteers (one male, one female); and blood for serum preparation was collected from four volunteers (two female, two male). AB - PRIMARY OUTCOME VARIABLES: (1) Fibronectin degradation and (2) expression of matrix metalloproteinases. AB - RESULTS: Fibronectin can be degraded in fluid from chronic wounds but remains intact in blood-derived serum, plasma-derived serum, blister fluid, and mastectomy wound fluid. Matrix metalloproteinases are overexpressed in fluid from chronic wounds compared with mastectomy wound fluid, blood-derived serum, and plasma-derived serum. Matrix metalloproteinases are also expressed of somewhat higher levels in mastectomy fluid than in blood-derived and plasma-derived serum. AB - CONCLUSIONS: These studies identified two factors that may contribute to delayed healing of chronic wound: fibronectin degradation and overexpression of matrix metalioproteinases. RN - 0 (Fibronectins) RN - EC 3-4-24 (Collagenases) RN - EC 3-4-24-17 (Matrix Metalloproteinase 3) RN - EC 3-4-24-35 (Matrix Metalloproteinase 9) IS - 1071-5754 IL - 1071-5754 PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PP - ppublish GI - No: NR03212 Organization: (NR) *NINR NIH HHS* Country: United States GI - No: NR03809 Organization: (NR) *NINR NIH HHS* Country: United States GI - No: NR03898 Organization: (NR) *NINR NIH HHS* Country: United States etc. LG - English DP - 1996 Nov EZ - 1996/11/01 DA - 1996/11/01 00:01 DT - 1996/11/01 00:00 YR - 1996 ED - 19970313 RD - 20161020 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=9043277 <500. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 8751807 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kimura M AU - Koida T AU - Sekihara M FA - Kimura, M FA - Koida, T FA - Sekihara, M IN - Kimura, M. Dept. of Surgery, Gunma Cancer Center, Japan. TI - [A case of recurrent breast cancer responding to long-term treatment with 5'-DFUR combined with MPA]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 23(9):1183-5, 1996 Aug AS - Gan To Kagaku Ryoho. 23(9):1183-5, 1996 Aug NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 23 IP - 9 PG - 1183-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Adenocarcinoma, Scirrhous/dt [Drug Therapy] MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Drug Administration Schedule MH - Female MH - Floxuridine/ad [Administration & Dosage] MH - Humans MH - Medroxyprogesterone Acetate/ad [Administration & Dosage] MH - Middle Aged MH - *Neoplasm Recurrence, Local/dt [Drug Therapy] AB - A 55-year-old woman with recurrent breast cancer treated with sequential mastectomies, chemo-and hormonal therapy of UFT, CPM and TAM, achieved remission. Six months later she was admitted with a diagnosis of carcinomatous pleurisy. A large pleural effusion was drained followed by administration of ADM, which improved her effusion and accompanying dyspnea. The effusion recurred but the patient desired outpatient treatment. Thus, we prescribed oral 5'-DFUR and MPA. One month later, her cough had improved and her sputum cytology was negative, while on chest radiograph the pleural effusion had decreased and the patch-like shadows in her right lung field had disappeared. She was considered as a case of PR. At one year and 3 months after starting concomitant 5'-DFUR and MPA the pleural effusion disappeared. The patient has received this outpatient treatment for 2 years without adverse reactions. RN - 039LU44I5M (Floxuridine) RN - C2QI4IOI2G (Medroxyprogesterone Acetate) RN - V1JK16Y2JP (doxifluridine) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1996 Aug EZ - 1996/08/01 DA - 1996/08/01 00:01 DT - 1996/08/01 00:00 YR - 1996 ED - 19960920 RD - 20151123 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=8751807 <501. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 7887649 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kinoshita S AU - Yoshida Y AU - Matsuda R AU - Takatsuki H AU - Shimahara Y AU - Kobayashi N FA - Kinoshita, S FA - Yoshida, Y FA - Matsuda, R FA - Takatsuki, H FA - Shimahara, Y FA - Kobayashi, N IN - Kinoshita, S. Ehime College of Health Science. TI - [A case of bilateral multiple lung metastases from breast cancer successfully treated with carboplatin]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 22(4):557-60, 1995 Mar AS - Gan To Kagaku Ryoho. 22(4):557-60, 1995 Mar NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 22 IP - 4 PG - 557-60 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Adenocarcinoma/dt [Drug Therapy] MH - *Adenocarcinoma/sc [Secondary] MH - Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/rt [Radiotherapy] MH - Breast Neoplasms/su [Surgery] MH - *Carboplatin/ad [Administration & Dosage] MH - Female MH - Humans MH - Infusions, Intravenous MH - *Lung Neoplasms/dt [Drug Therapy] MH - *Lung Neoplasms/sc [Secondary] MH - Lymphatic Metastasis MH - Mastectomy, Modified Radical MH - Medroxyprogesterone/ad [Administration & Dosage] MH - Middle Aged MH - Tegafur/ad [Administration & Dosage] MH - Uracil/ad [Administration & Dosage] AB - A 57-year-old female was admitted for right breast tumor. Modified radical mastectomy (Kodama method) was carried out. A prophylactic postoperative radiation was undertaken because of large tumor (T4b) and histologic metastasis to a Rotter's lymph node. At the end of irradiation, bilateral lung metastases were found on chest CT gram. The combination endocrine chemotherapy using MPA 600 mg and UFT 3 capsules p.o. daily and ADM 10 or 20 mg i.v. every two weeks was performed on an outpatient basis. As the lung metastases were increased four months later, carboplatin 150 mg i.v. was replaced with ADM. Four months later, the metastases almost disappeared on CT gram. These results suggested the possibility of one of the therapeutic options for metastatic breast cancer. RN - 1548R74NSZ (Tegafur) RN - 56HH86ZVCT (Uracil) RN - BG3F62OND5 (Carboplatin) RN - HSU1C9YRES (Medroxyprogesterone) PS - 1-UFT protocol IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1995 Mar EZ - 1995/03/01 DA - 1995/03/01 00:01 DT - 1995/03/01 00:00 YR - 1995 ED - 19950410 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=7887649 <502. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 7944459 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Yokoyama S AU - Sugenoya A AU - Kasuga Y AU - Fujimori M AU - Oguchi M AU - Abe N AU - Tsuchiya S AU - Iida F FA - Yokoyama, S FA - Sugenoya, A FA - Kasuga, Y FA - Fujimori, M FA - Oguchi, M FA - Abe, N FA - Tsuchiya, S FA - Iida, F IN - Yokoyama, S. Dept. of Surgery, Shinshu University School of Medicine. TI - [Combination neoadjuvant therapy with continuous intra-arterial CDDP infusion and radiotherapy for locally advanced breast cancer]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 21(13):2278-81, 1994 Sep AS - Gan To Kagaku Ryoho. 21(13):2278-81, 1994 Sep NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 21 IP - 13 PG - 2278-81 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/rt [Radiotherapy] MH - Chemotherapy, Adjuvant MH - *Cisplatin/ad [Administration & Dosage] MH - Female MH - Humans MH - *Infusions, Intra-Arterial MH - Radiotherapy, High-Energy AB - Neoadjuvant therapy combined with intra-arterial continuous infusion of CDDP and external radiation was evaluated in a patient with locally advanced breast cancer. Although only MR was observed on the primary tumor, PR was found in several metastatic lymph nodes and daughter nodules. All tumor markers elevated before treatment decreased to normal ranges only by this therapy, and histological damage was also recognized remarkably with a high concentration of free Pt (8.89 micrograms/g) in cancer tissues. Since no severe side effects appeared during the present therapy, extended radical mastectomy with wide skin resection could be performed following additional intra-arterial chemotherapy using 5-FU, epi-ADM and MMC. From this experience, it was suggested that CDDP was an useful drug in the chemotherapy for breast cancer. RN - Q20Q21Q62J (Cisplatin) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1994 Sep EZ - 1994/09/01 DA - 1994/09/01 00:01 DT - 1994/09/01 00:00 YR - 1994 ED - 19941102 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=7944459 <503. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 8373227 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kan N AU - Harada T AU - Kodama H AU - Ichinose Y AU - Moriguchi Y AU - Sugie T AU - Li L AU - Sato K AU - Imamura M FA - Kan, N FA - Harada, T FA - Kodama, H FA - Ichinose, Y FA - Moriguchi, Y FA - Sugie, T FA - Li, L FA - Sato, K FA - Imamura, M IN - Kan, N. First Dept of Surgery, Kyoto University, Faculty of Medicine. TI - [Transarterial immuno-chemotherapy including adoptive transfer of autologous cultured lymphocytes for stage IV breast cancer patients with locally-advanced tumor]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 20(11):1593-6, 1993 Aug AS - Gan To Kagaku Ryoho. 20(11):1593-6, 1993 Aug NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 20 IP - 11 PG - 1593-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - Aged MH - *Antineoplastic Combined Chemotherapy Protocols/ad [Administration & Dosage] MH - Breast Neoplasms/pa [Pathology] MH - *Breast Neoplasms/th [Therapy] MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - *Immunotherapy, Adoptive MH - Infusions, Intra-Arterial MH - *Lymphocytes, Tumor-Infiltrating/tr [Transplantation] MH - Middle Aged MH - Picibanil/ad [Administration & Dosage] MH - Subclavian Artery AB - Immuno-chemotherapy via a catheter in the subclavian artery using sequential treatment with OK-432, chemotherapeutic agents (ADM, 5-FU), and cultured autologous lymphocytes, was performed for 9 Stage IV breast cancer patients with locally-advanced primary tumor. Tumor reduction of more than 50% was observed in 8 patients including 4 whose breast tumors had disappeared. Among 11 evaluable distant metastatic lesions, 7 (1 pleural effusion, 2 lung, 2 liver, 2 bone metastases) regressed after local immunotherapy of breast or additional regional immunotherapy (1 lung, 1 liver, 1 pleural effusion). Median survival time to date is 56 months. Five patients are currently alive, although 3 of them did not undergo mastectomy. Local immuno-chemotherapy may be useful because (a) toxicity is limited, (b) low doses of anti-cancer agents during the therapy (median dose of ADM, 60 mg) do not limit subsequent systemic chemotherapy, and (c) distant metastases often regress concomitantly with the primary lesions. RN - 39325-01-4 (Picibanil) RN - 80168379AG (Doxorubicin) RN - U3P01618RT (Fluorouracil) IS - 0385-0684 IL - 0385-0684 PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1993 Aug EZ - 1993/08/01 DA - 1993/08/01 00:01 DT - 1993/08/01 00:00 YR - 1993 ED - 19931008 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=8373227 <504. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 8373226 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mukai S AU - Sato N AU - Tamegai Y AU - Morikoshi E AU - Watanabe K FA - Mukai, S FA - Sato, N FA - Tamegai, Y FA - Morikoshi, E FA - Watanabe, K IN - Mukai, S. Dept. of Surgery, Kosei General Hospital. TI - [Two cases of stage IIIb breast cancer treated by intra-arterial infusion chemotherapy using implantable reservoir combined with rectus-abdominis musculocutaneous flap reconstruction after mastectomy]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 20(11):1589-92, 1993 Aug AS - Gan To Kagaku Ryoho. 20(11):1589-92, 1993 Aug NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 20 IP - 11 PG - 1589-92 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Chemotherapy, Adjuvant MH - *Doxorubicin/ad [Administration & Dosage] MH - Female MH - Humans MH - *Infusion Pumps, Implantable MH - Infusions, Intra-Arterial MH - *Mammaplasty/mt [Methods] MH - *Mastectomy MH - Middle Aged MH - Subclavian Artery MH - Surgical Flaps AB - Intra-arterial infusion chemotherapy was performed using implantable reservoir for 2 cases of Stage IIIb breast cancer followed by rectus-abdominis musculocutaneous flap reconstruction after mastectomy. The first case is a 47-year-old female. A total dose of 150 mg ADM was injected via reservoir. After satisfactory local response, mastectomy followed by giant rectus-abdominis musculocutaneous flap reconstruction was performed. The other case is a 64-year-old female. A total dose of 160 mg ADM was injected via reservoir. She was also operated in the same manner as in the first case. Complications of both cases were minimal. It was concluded that this combined treatment was useful for controlling local lesion and sustaining QOL. RN - 80168379AG (Doxorubicin) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1993 Aug EZ - 1993/08/01 DA - 1993/08/01 00:01 DT - 1993/08/01 00:00 YR - 1993 ED - 19931008 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=8373226 <505. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 1877841 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Mukai S AU - Sato N AU - Saito M AU - Tamegai Y AU - Morikoshi E FA - Mukai, S FA - Sato, N FA - Saito, M FA - Tamegai, Y FA - Morikoshi, E IN - Mukai, S. Dept. of Surgery, Kosei General Hospital. TI - [Two cases of stage IV breast cancer with locally advanced lesion treated by intra-arterial infusion chemotherapy using implantable reservoir]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 18(11):1972-5, 1991 Aug AS - Gan To Kagaku Ryoho. 18(11):1972-5, 1991 Aug NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 18 IP - 11 PG - 1972-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Aged MH - Bone Neoplasms/sc [Secondary] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - Catheterization MH - Combined Modality Therapy MH - *Doxorubicin/ad [Administration & Dosage] MH - Female MH - Humans MH - *Infusion Pumps, Implantable MH - Infusions, Intra-Arterial MH - Lymphatic Metastasis MH - Mastectomy, Radical MH - Middle Aged AB - Intra-arterial infusion chemotherapy was used for 2 cases of Stage IV breast cancer with locally advanced lesions using implantable reservoir. The first case is a 64-year-old female who had multiple bone metastases with locally advanced breast lesion. A total dose of 220 mg ADM was injected via reservoir at outpatient department. The other case is a 66-year-old female who had multiple bone metastases with locally advanced breast lesions. A total dose of 235 mg ADM was injected via reservoir. After obtaining satisfactory response of local lesions, a standard radical mastectomy was performed for both cases. It was concluded that this method was useful for controlling locally advanced lesions of Stage IV breast cancer and beneficial for patient QOL. RN - 80168379AG (Doxorubicin) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1991 Aug EZ - 1991/08/01 DA - 1991/08/01 00:01 DT - 1991/08/01 00:00 YR - 1991 ED - 19910924 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=1877841 <506. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 2522156 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Kusama M AU - Kimura K AU - Aoki T AU - Suzuki K AU - Kakuta T AU - Ishikawa M AU - Yoshimatsu A FA - Kusama, M FA - Kimura, K FA - Aoki, T FA - Suzuki, K FA - Kakuta, T FA - Ishikawa, M FA - Yoshimatsu, A IN - Kusama, M. Dept. of Surgery, Tokyo Medical College. TI - [Complete remission, obtained by multidisciplinary treatment of recurrent breast cancer with carcinomatous pleuritis, and cervical lymph node and diver metastasis]. [Japanese] SO - Gan No Rinsho - Japanese Journal of Cancer Clinics. 35(1):93-9, 1989 Jan AS - Gan No Rinsho. 35(1):93-9, 1989 Jan NJ - Gan no rinsho. Japan journal of cancer clinics VO - 35 IP - 1 PG - 93-9 PI - Journal available in: Print PI - Citation processed from: Print JC - kif, 1257753 IO - Gan No Rinsho SB - Index Medicus CP - Japan MH - Adenocarcinoma/dt [Drug Therapy] MH - *Adenocarcinoma/sc [Secondary] MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - Cisplatin/ad [Administration & Dosage] MH - Combined Modality Therapy MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Administration Schedule MH - Female MH - Humans MH - Infusions, Intra-Arterial MH - Liver Neoplasms/dt [Drug Therapy] MH - *Liver Neoplasms/sc [Secondary] MH - Lymphatic Metastasis MH - Medroxyprogesterone/ad [Administration & Dosage] MH - Medroxyprogesterone/aa [Analogs & Derivatives] MH - Medroxyprogesterone Acetate MH - *Pleurisy/dt [Drug Therapy] MH - Remission Induction AB - A 46-year-old female, who had undergone a radical mastectomy for cancer of the breast 5 years previously at another institution presented a pleural effusion, in which malignant cells were detected, along with cervical lymph node metastasis. Although the patient initially responded to the H-CMcF regimen and intrathoracic injections of adriamycin (ADM), her condition subsequently was exacerbated, with metastasis occurring in the liver. A complete remission however, was achieved by local treatment, which included intrathoracic infusions of ADM and cis-platinum plus hepatic artery infusions of ADM and lipiodol, in addition to a systemic treatment consisting of a modification of the FEMP regimen employing UFT, CPA, MMC, and PDN, to which were added the immunopotentiators OK-432 and MPA. At present, 18 months after treatment, the patient is apparently disease free. The results obtained in this case suggest that even a distant metastasis can be controlled by aggressive local treatment for each metastatic lesion, in addition to a multidisciplinary treatment based mainly on intensive chemotherapy. RN - 80168379AG (Doxorubicin) RN - C2QI4IOI2G (Medroxyprogesterone Acetate) RN - HSU1C9YRES (Medroxyprogesterone) RN - Q20Q21Q62J (Cisplatin) IS - 0021-4949 IL - 0021-4949 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1989 Jan EZ - 1989/01/01 DA - 1989/01/01 00:01 DT - 1989/01/01 00:00 YR - 1989 ED - 19890411 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=2522156 <507. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 3173706 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Fornero G AU - Ganio E AU - Trompetto M AU - Clerico G FA - Fornero, G FA - Ganio, E FA - Trompetto, M FA - Clerico, G TI - [Benign and malignant neoformations of the male breast. Our personal series]. [Italian] OT - Neoformazioni benigne e maligne della mammella maschile. Nostro contributo. SO - Minerva Chirurgica. 43(11):939-42, 1988 Jun 15 AS - Minerva Chir. 43(11):939-42, 1988 Jun 15 NJ - Minerva chirurgica VO - 43 IP - 11 PG - 939-42 PI - Journal available in: Print PI - Citation processed from: Print JC - n3i, 0400726 IO - Minerva Chir SB - Index Medicus CP - Italy MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Breast Neoplasms/su [Surgery] MH - Humans MH - Male MH - Mastectomy, Simple MH - Mastectomy, Subcutaneous MH - Middle Aged MH - Sex Factors IS - 0026-4733 IL - 0026-4733 PT - English Abstract PT - Journal Article PP - ppublish LG - Italian DP - 1988 Jun 15 EZ - 1988/06/15 DA - 1988/06/15 00:01 DT - 1988/06/15 00:00 YR - 1988 ED - 19881116 RD - 20061115 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=3173706 <508. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 3140732 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Ishikawa H AU - Murayama N AU - Kasahara M AU - Ikoma M AU - Takenaka Y AU - Yoshida H AU - Shimada A AU - Watanabe M FA - Ishikawa, H FA - Murayama, N FA - Kasahara, M FA - Ikoma, M FA - Takenaka, Y FA - Yoshida, H FA - Shimada, A FA - Watanabe, M IN - Ishikawa, H. Dept. of Surgery, Keiyu General Hospital. TI - [Preoperative intra-arterial infusion chemotherapy in locally advanced primary breast cancer-tissue concentrations of 5-fluorouracil and adriamycin, and the histological evaluation]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 15(10):2911-6, 1988 Oct AS - Gan To Kagaku Ryoho. 15(10):2911-6, 1988 Oct NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 15 IP - 10 PG - 2911-6 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - Aged MH - Aged, 80 and over MH - Antineoplastic Combined Chemotherapy Protocols/ad [Administration & Dosage] MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - *Breast/me [Metabolism] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/th [Therapy] MH - Combined Modality Therapy MH - Doxorubicin/ad [Administration & Dosage] MH - *Doxorubicin/pk [Pharmacokinetics] MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - *Fluorouracil/pk [Pharmacokinetics] MH - Humans MH - Infusions, Intra-Arterial MH - Lymph Nodes/me [Metabolism] MH - Mastectomy, Radical MH - Middle Aged MH - Mitomycin MH - Mitomycins/ad [Administration & Dosage] MH - Mitomycins/pk [Pharmacokinetics] MH - Preoperative Care MH - Prognosis AB - The effect of preoperative intra-arterial infusion of mitomycin C, 5-fluorouracil (5-FU) and adriamycin (ADM) were studied in seven patients with locally advanced breast cancer, including five inflammatory carcinomas, and a patient with stromal sarcoma of the breast. Reducing rate of the primary tumor of more than 30% was observed in all cases, and remarkable degenerative changes of tumor cells were histologically noted in six out of eight surgical specimens. The tissue concentrations of 5-FU and ADM were also studied in five breast cancer patients. There was no correlation between the concentration of 5-FU or ADM and histological effect. In intra-arterial infusion, ADM seemed to have a high affinity to the regional lymphnode and breast tumor, compared to normal breast tissue and might also be applicable to the control of lymphnode metastasis. Three out of six cases which received radical mastectomy subsequently had recurrence except in the regional lymphnodes and the prognosis was unsatisfactory (5 year survival was 2/4). Other alternative or multi-disciplinary treatment seems to be necessary for improving the survival rate. RN - 0 (Mitomycins) RN - 50SG953SK6 (Mitomycin) RN - 80168379AG (Doxorubicin) RN - U3P01618RT (Fluorouracil) IS - 0385-0684 IL - 0385-0684 PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1988 Oct EZ - 1988/10/01 DA - 1988/10/01 00:01 DT - 1988/10/01 00:00 YR - 1988 ED - 19881107 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=3140732 <509. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 3395141 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tachibana K AU - Furukawa M AU - Nakata T AU - Setoguchi M AU - Kusano T AU - Lin Y AU - Tashiro K AU - Suga K AU - Miyazaki K FA - Tachibana, K FA - Furukawa, M FA - Nakata, T FA - Setoguchi, M FA - Kusano, T FA - Lin, Y FA - Tashiro, K FA - Suga, K FA - Miyazaki, K IN - Tachibana, K. Dept. of Surgery, National Nagasaki Chuo Hospital. TI - [A case report of the effective arterial infusion for advanced recurrence breast cancer with 5-FU, ADM, CDDP and OK-432]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 15(7):2169-71, 1988 Jul AS - Gan To Kagaku Ryoho. 15(7):2169-71, 1988 Jul NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 15 IP - 7 PG - 2169-71 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] MH - Breast Neoplasms/pa [Pathology] MH - Breast Neoplasms/su [Surgery] MH - *Breast Neoplasms/th [Therapy] MH - Cisplatin/ad [Administration & Dosage] MH - Combined Modality Therapy MH - Doxorubicin/ad [Administration & Dosage] MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - Infusions, Intra-Arterial MH - Lymph Node Excision MH - Mastectomy MH - Picibanil/ad [Administration & Dosage] AB - A 42-year-old female visited our hospital because of left breast tumor and left arm swelling with severe pain. She had had right radical mastectomy and bilateral oophorectomy at 27 and 29 years of age, respectively. On admission, she had a hard mass, which seemed to be a severe invasion of the chest wall, on her left breast with a severe nipple ulcer. We inserted a catheter operatively through the thyrocervical truncus to the subclavian artery for the arterial infusion therapy. She was administered 250 mg of 5-FU daily, and 10 mg of ADM, 10 mg of CDDP, 10 KE of OK-432, every other week. During 70 days, 10,000 mg of 5-FU, 50 mg of ADM, 50 mg of CDDP and 50 KE of OK-432 were administered. As soon as the breast tumor became smaller, showed some mobility and the nipple ulcer healed, we carried out left mastectomy and axillary lymph node dissection. Pathological findings showed severe degeneration and necrosis of cancer cells. Lymphocytes surrounded necrotic tissue, and there was a follicular pattern of invasion. This phenomenon was considered to result from the promotion of cellular immunological reaction by OK-432. RN - 39325-01-4 (Picibanil) RN - 80168379AG (Doxorubicin) RN - Q20Q21Q62J (Cisplatin) RN - U3P01618RT (Fluorouracil) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PP - ppublish LG - Japanese DP - 1988 Jul EZ - 1988/07/01 DA - 1988/07/01 00:01 DT - 1988/07/01 00:00 YR - 1988 ED - 19880822 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=3395141 <510. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 3392846 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Iwasa Z AU - Matsunami N AU - Saeki Y AU - Kurooka K AU - Yamato M AU - Okuno K AU - Sagara N AU - Matsuda T AU - Yasutomi M FA - Iwasa, Z FA - Matsunami, N FA - Saeki, Y FA - Kurooka, K FA - Yamato, M FA - Okuno, K FA - Sagara, N FA - Matsuda, T FA - Yasutomi, M IN - Iwasa, Z. First Department of Surgery, Kinki University School of Medicine, Osaka, Japan. TI - The follow up study of intra-arterial infusion chemotherapy with local vein blocking as a surgical neo-adjuvant treatment for locally advanced breast cancer. SO - Japanese Journal of Surgery. 18(2):131-5, 1988 Mar AS - Jpn J Surg. 18(2):131-5, 1988 Mar NJ - The Japanese journal of surgery VO - 18 IP - 2 PG - 131-5 PI - Journal available in: Print PI - Citation processed from: Print JC - 1302176, kqb IO - Jpn J Surg SB - Index Medicus CP - Japan MH - *Breast/bs [Blood Supply] MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/su [Surgery] MH - *Doxorubicin/ad [Administration & Dosage] MH - Drug Therapy, Combination MH - Female MH - *Fluorouracil/ad [Administration & Dosage] MH - Follow-Up Studies MH - Humans MH - Infusions, Intra-Arterial MH - Ligation MH - Lymphatic Metastasis MH - Mastectomy MH - Neoplasm Recurrence, Local MH - *Premedication MH - Veins/su [Surgery] AB - Preoperative intra-arterial infusion neo-adjuvant chemotherapy, in combination with local vein blocking, was administered to thirty-one patients with locally advanced stage III breast cancer. The anti-cancer drugs and dosages used were 500 mg of 5-Fluorouracil (5FU), which was infused daily for 7-14 days, and 20 mg of Adriamycin (ADM), which was administered as a bolus dose twice into the subclavian and internal mammary arteries. The response rate of this method on the primary tumor was 48.4 per cent, and, histologically it was found to be as high as 90.3 per cent. The response rate of the clinical effects on the regional lymph nodes was 50.0 per cent, however, histologically, it was found to be lower than that of the primary tumor. In the long-term follow-up study the 5-year survival rate was 72.2 per cent. Thus, this method seems to be effective as a combined modality in cases of locally advanced stage III breast cancer. RN - 80168379AG (Doxorubicin) RN - U3P01618RT (Fluorouracil) IS - 0047-1909 IL - 0047-1909 PT - Journal Article PP - ppublish LG - English DP - 1988 Mar EZ - 1988/03/01 DA - 1988/03/01 00:01 DT - 1988/03/01 00:00 YR - 1988 ED - 19880818 RD - 20170812 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=3392846 <511. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 3631975 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Nakagawa H AU - Kikuhara M AU - Sato M AU - Sakai K AU - Kimura S FA - Nakagawa, H FA - Kikuhara, M FA - Sato, M FA - Sakai, K FA - Kimura, S TI - [A case report of inflammatory breast cancer effectively treated with cis-platinum]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 14(9):2767-70, 1987 Sep AS - Gan To Kagaku Ryoho. 14(9):2767-70, 1987 Sep NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 14 IP - 9 PG - 2767-70 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/su [Surgery] MH - Cisplatin/ad [Administration & Dosage] MH - *Cisplatin/tu [Therapeutic Use] MH - Drug Administration Schedule MH - Female MH - Humans MH - Mastectomy MH - Mastitis/dt [Drug Therapy] MH - Middle Aged MH - Skin Neoplasms/sc [Secondary] AB - A 50-year-old woman with bilateral inflammatory breast cancer (T4, N1b, M1, Stage IV) underwent right extended radical mastectomy and left modified radical mastectomy following pre-operative administration of carcinostatics (ADM, 5-FU) and irradiation. However, tumor recurrence was observed at the skin and right pleural cavity after the operation. Adriamycin-containing combination chemotherapy and radiation therapy were performed, but no significant response was obtained. CDDP was then administered intravenously at a daily dose of 62.5 mg/m2 at intervals of 60 days. The pleural effusion disappeared and the extent of skin metastasis was reduced, resulting in partial response which lasted for 90 days. The serum CEA level decreased from 13.1 ng/ml to 2.3 ng/ml. As the side effects of this therapy, slight nausea, vomiting and general fatigue were observed. This result suggested that CDDP is an effective drug for inflammatory breast cancer. RN - Q20Q21Q62J (Cisplatin) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1987 Sep EZ - 1987/09/01 DA - 1987/09/01 00:01 DT - 1987/09/01 00:00 YR - 1987 ED - 19871008 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med2&AN=3631975 <512. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 3457552 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Tokunaga Y AU - Konishi Y AU - Nakamoto K AU - Ohara H AU - Terai T AU - Yamauchi Y AU - Nagano Y FA - Tokunaga, Y FA - Konishi, Y FA - Nakamoto, K FA - Ohara, H FA - Terai, T FA - Yamauchi, Y FA - Nagano, Y TI - [Successful chemotherapy in postoperative brain metastasis of breast cancer using ACNU--two case reports]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 13(4 Pt 1):1070-3, 1986 Apr AS - Gan To Kagaku Ryoho. 13(4 Pt 1):1070-3, 1986 Apr NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 13 IP - 4 Pt 1 PG - 1070-3 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - *Antineoplastic Agents/tu [Therapeutic Use] MH - Brain Neoplasms/dt [Drug Therapy] MH - *Brain Neoplasms/sc [Secondary] MH - Breast Neoplasms/su [Surgery] MH - *Breast Neoplasms MH - Carcinoma/dt [Drug Therapy] MH - *Carcinoma/sc [Secondary] MH - Carcinoma, Papillary/dt [Drug Therapy] MH - *Carcinoma, Papillary/sc [Secondary] MH - Female MH - Humans MH - *Mastectomy MH - Middle Aged MH - Nimustine MH - *Nitrosourea Compounds/tu [Therapeutic Use] MH - Postoperative Period AB - Two cases of postoperative brain metastasis of breast cancer were evaluated after chemotherapy using ACNU. Case 1: A 47-year-old female, who had undergone right standard radical mastectomy in 1979 for breast cancer (T2 N0M0, papillo-tubular carcinoma), was treated with ADM, TAM, and 60Co irradiation for bone metastasis in 1983. In 1984, she complained of loss of consciousness and paralysis of the extremities due to brain metastasis. After chemotherapy using ACNU (100 mg X 3), brain metastasis could not be detected on CT. She remained asymptomatic for more than 9 months without recurrence after therapy. Case 2: A 46-year-old-female, who had undergone left standard radical mastectomy in 1980 for breast cancer (T1 N1 M0, medullar tubular carcinoma), complained of headache and vertigo accompanying a hard tumor in the scalp. Chest X-ray and CT demonstrated right lung metastasis and left cerebellar metastasis. After combination chemotherapy using ACNU (100 mg) + MMC (4 mg) i.v. and FT (600 mg/day) p.o., symptoms and tumor on CT disappeared for 10 months after therapy. However, the patient died of aggravation of angina pectoris and D.M. from which she had been suffering for several years previously. These two cases correspond to complete response (CR) according to the response criteria proposed by Koyama-Saitoh. RN - 0 (Antineoplastic Agents) RN - 0 (Nitrosourea Compounds) RN - 0S726V972K (Nimustine) IS - 0385-0684 IL - 0385-0684 PT - Case Reports PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1986 Apr EZ - 1986/04/01 DA - 1986/04/01 00:01 DT - 1986/04/01 00:00 YR - 1986 ED - 19860512 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med2&AN=3457552 <513. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 7184432 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Takatsuka Y AU - Imamotoh H AU - Tsuchiyama M AU - Numata N AU - Kawahara T FA - Takatsuka, Y FA - Imamotoh, H FA - Tsuchiyama, M FA - Numata, N FA - Kawahara, T TI - [Intra-arterial infusion chemotherapy with adriamycin for the treatment of locally advanced breast cancer--studies of serum and tissue concentrations of adriamycin]. [Japanese] SO - Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 9(5):880-7, 1982 May AS - Gan To Kagaku Ryoho. 9(5):880-7, 1982 May NJ - Gan to kagaku ryoho. Cancer & chemotherapy VO - 9 IP - 5 PG - 880-7 PI - Journal available in: Print PI - Citation processed from: Print JC - 7810034, 6t8 IO - Gan To Kagaku Ryoho SB - Index Medicus CP - Japan MH - Adult MH - Aged MH - *Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/me [Metabolism] MH - Breast Neoplasms/pa [Pathology] MH - *Doxorubicin/ad [Administration & Dosage] MH - Doxorubicin/bl [Blood] MH - Doxorubicin/me [Metabolism] MH - Female MH - Humans MH - Infusions, Intra-Arterial MH - Lymphatic Metastasis MH - Middle Aged AB - The effect of intra-arterial infusion chemotherapy with adriamycin (ADM), with special references to its pharmacokinetic behavior and also the tissue concentrations, was studied in 8 patients with locally advanced breast cancer. A high clinical response rate (CR + PR) of 70.0% was obtained by the treatment, and also remarkable degenerative changes of tumor cells were histologically noted in 5 out of 9 surgical specimens (55.6%). Side effects such as alopecia (100%), leukopenia (87.5%) and stomatitis (85.5%) were frequently observed, but none of them delayed the following mastectomy. Pharmacokinetic studies of intra-arterial administration of ADM showed a low serum concentration and its rapid clearance from serum. ADM also seemed to have a great affinity to the regional lymph nodes (1.21 micrograms/g tissue), compared to cancer (0.61 micrograms/g) and normal breast tissues (0.51 micrograms/g). These results suggested that intra-arterial infusion chemotherapy with ADM might be applicable not only for the preoperative treatment of locally advanced breast cancer, but also for the control of lymph node metastasis. RN - 80168379AG (Doxorubicin) IS - 0385-0684 IL - 0385-0684 PT - English Abstract PT - Journal Article PP - ppublish LG - Japanese DP - 1982 May EZ - 1982/05/01 DA - 1982/05/01 00:01 DT - 1982/05/01 00:00 YR - 1982 ED - 19830817 RD - 20131121 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med2&AN=7184432 <514. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 7048518 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - MEDLINE AU - Cavalli F AU - Beer M AU - Martz G AU - Jungi WF AU - Alberto P AU - Obrecht JP AU - Mermillod B AU - Brunner KW FA - Cavalli, F FA - Beer, M FA - Martz, G FA - Jungi, W F FA - Alberto, P FA - Obrecht, J P FA - Mermillod, B FA - Brunner, K W TI - [Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer]. [German] OT - Gleichzeitige oder sequentielle Hormono/Chemotherapie sowie Vergleich verschiedener Polychemotherapien in der Behandlung des metastasierenden Mammakarzinoms. SO - Schweizerische Medizinische Wochenschrift. Journal Suisse de Medecine. 112(22):774-83, 1982 May 29 AS - Schweiz Med Wochenschr. 112(22):774-83, 1982 May 29 NJ - Schweizerische medizinische Wochenschrift VO - 112 IP - 22 PG - 774-83 PI - Journal available in: Print PI - Citation processed from: Print JC - uei, 0404401 IO - Schweiz Med Wochenschr SB - Index Medicus CP - Switzerland MH - Adult MH - Aged MH - *Antineoplastic Agents/ad [Administration & Dosage] MH - Antineoplastic Agents/tu [Therapeutic Use] MH - Breast Neoplasms/dt [Drug Therapy] MH - Breast Neoplasms/mo [Mortality] MH - *Breast Neoplasms/th [Therapy] MH - Castration MH - Chlorambucil/ad [Administration & Dosage] MH - Clinical Trials as Topic MH - Doxorubicin/ad [Administration & Dosage] MH - Drug Therapy, Combination MH - Female MH - Fluorouracil/ad [Administration & Dosage] MH - Humans MH - Mastectomy MH - Menopause MH - Methotrexate/ad [Administration & Dosage] MH - Middle Aged MH - Neoplasm Metastasis MH - Prednisone/ad [Administration & Dosage] MH - *Tamoxifen/ad [Administration & Dosage] MH - Tamoxifen/tu [Therapeutic Use] MH - Vincristine/ad [Administration & Dosage] AB - Since in the treatment of advanced breast cancer chemotherapy and the various hormonal manipulations seem recently to have reached a plateau of effectiveness when used alone, it is widely assumed that the combination of both treatment modalities could improve therapeutic results. The outcome is reported of a study encompassing 109 pre- and 297 postmenopausal evaluable cases with previously untreated metastatic breast cancer. The patients were randomized either to a concurrent chemo/hormonotherapy or to the hormonal treatment alone, chemotherapy being delayed until the occurrence of tumor progression. All patients were further randomized to 3 chemotherapy regimens (LMFP, LMP/FVP, LMFP/ADM) representing three different degrees of intensity. Pre-menopausal patients tend to live longer with the concurrent combination of both modalities, whereas postmenopausal patients fare better when chemotherapy is delayed until the occurrence of tumor progression with hormonotherapy alone. However, the differences in survival are statistically significant only in postmenopausal patients with a less aggressive tumor ("low-risk"). The more aggressive cytotoxic combinations elicit higher response rates than "minimal chemotherapy", but the differences translate only marginally into different survivals. These findings are discussed with regard in particular to their importance in establishing widely acceptable therapeutic rules for the treatment of advanced breast cancer. RN - 0 (Antineoplastic Agents) RN - 094ZI81Y45 (Tamoxifen) RN - 18D0SL7309 (Chlorambucil) RN - 5J49Q6B70F (Vincristine) RN - 80168379AG (Doxorubicin) RN - U3P01618RT (Fluorouracil) RN - VB0R961HZT (Prednisone) RN - YL5FZ2Y5U1 (Methotrexate) IS - 0036-7672 IL - 0036-7672 PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial PP - ppublish LG - German DP - 1982 May 29 EZ - 1982/05/29 DA - 1982/05/29 00:01 DT - 1982/05/29 00:00 YR - 1982 ED - 19820917 RD - 20151119 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med2&AN=7048518 <515. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29632762 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Moyer HR AU - Hart AM AU - Yeager J AU - Losken A FA - Moyer, Hunter R FA - Hart, Alexandra M FA - Yeager, Jessica FA - Losken, Albert IN - Moyer, Hunter R. Emory University, Division of Plastic and Reconstructive Surgery, Atlanta, Ga.; Atlanta Plastic Surgery, Atlanta, Ga. IN - Hart, Alexandra M. Emory University, Division of Plastic and Reconstructive Surgery, Atlanta, Ga.; Atlanta Plastic Surgery, Atlanta, Ga. IN - Yeager, Jessica. Emory University, Division of Plastic and Reconstructive Surgery, Atlanta, Ga.; Atlanta Plastic Surgery, Atlanta, Ga. IN - Losken, Albert. Emory University, Division of Plastic and Reconstructive Surgery, Atlanta, Ga.; Atlanta Plastic Surgery, Atlanta, Ga. TI - A Histological Comparison of Two Human Acellular Dermal Matrix Products in Prosthetic-Based Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 5(12):e1576, 2017 Dec AS - Plast. reconstr. surg., Glob. open. 5(12):e1576, 2017 Dec NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 12 PG - e1576 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Background: Acellular dermal matrices (ADMs) are an integral component of breast reconstruction. The ideal matrix would be relatively immuno-inert, allow rapid vascularization, and be affordable. The purpose of this study was to histologically compare 2 commonly used ADM products. AB - Methods: This is a prospective histological study of 17 patients (20 breasts) following prosthetic-based breast reconstruction with ADM: Alloderm (LifeCell Corp, Branchburg, N.J.) or Cortiva (RTI Surgical, Alachua Fla.). Biopsies were taken from the dermal matrix and natural capsules surrounding the expander/implant during secondary surgery [Range, 72-694 days (mean, 217 days)]. Biopsy specimens were prepared via hematoxylin and eosin, Masson's trichrome, elastin, and transforming growth factor (TGF)-1 stains. Quantitative analysis of staining was performed with ImageJ software. The clinical outcome of each patient is analyzed in relation to capsule architecture and ADM performance. AB - Results: There were 7 breasts in the Alloderm group and 13 in the Cortiva group. Both groups had similar demographic, aesthetic results, and complication profiles. The TGF-1 staining demonstrated significantly lower levels in the Cortiva capsules (P = 0.0139). The percentage of elastin and collagen are similar in the Cortiva, Alloderm, and natural peri-implant capsules. The native capsules show a significantly greater number of blood vessels when compared with Cortiva and Alloderm (P = 0.0371 and P = 0.0347, respectively); however, there is no difference in vascular pattern between the 2 dermal matrices. AB - Discussion: Postoperatively, Cortiva demonstrates equal vascularity with less TGF-1 activation compared with Alloderm. The clinical success and complication profile were similar between the Alloderm and Cortiva patients. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001576 PT - Journal Article ID - 10.1097/GOX.0000000000001576 [doi] ID - PMC5889434 [pmc] PP - epublish PH - 2017/06/23 [received] PH - 2017/09/29 [accepted] LG - English EP - 20171227 DP - 2017 Dec EZ - 2018/04/11 06:00 DA - 2018/04/11 06:01 DT - 2018/04/11 06:00 YR - 2017 RD - 20180412 UP - 20180412 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29632762 <516. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29489547 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Sue GR AU - Sun BJ AU - Lee GK FA - Sue, Gloria R FA - Sun, Beatrice J FA - Lee, Gordon K IN - Sue, Gloria R. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford Health Care, Stanford, CA. TI - Complications After Two-Stage Expander Implant Breast Reconstruction Requiring Reoperation: A Critical Analysis of Outcomes. SO - Annals of Plastic Surgery. 80(5S Suppl 5):S292-S294, 2018 May AS - Ann Plast Surg. 80(5S Suppl 5):S292-S294, 2018 May NJ - Annals of plastic surgery VO - 80 IP - 5S Suppl 5 PG - S292-S294 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - BACKGROUND: Two-stage expander implant breast reconstruction is commonly performed after mastectomy. Salvage and long-term outcomes after development of complications have not been well described. We examined a single surgeon's experience to study the rate of reoperation secondary to complications after first-stage expander placement and to evaluate their outcomes. Better understanding of salvage techniques may help guide future management. AB - METHODS: We performed a retrospective analysis of consecutive patients who underwent placement of a tissue expander (TE) for breast reconstruction between December 2006 and August 2015 with the senior author. Patient demographics including age, body mass index, medical comorbidities, history of smoking, and history of radiation to the breast were collected. Surgical factors including timing of reconstruction (immediate vs delayed) and location of TE (total submuscular vs with acellular dermal matrix) were recorded. Complications were analyzed, as were patients who underwent reoperation in the setting of developing a complication. AB - RESULTS: We analyzed 282 patients who underwent 453 implant-based breast reconstructions. Of these, 39 patients and 45 breasts required a reoperation after development of a postoperative complication. Return to the operating room was associated with higher body mass index (29 vs 24, P < 0.001), higher TE initial fill volume (299 mL vs 169 mL, P < 0.001), and preoperative radiation (31% vs 13%, P = 0.001). Complications resulting in reoperation included infection (60%), mastectomy skin necrosis (27%), and TE extrusion through thin mastectomy skin (11%). The affected TE was removed and exchanged in 17 patients (38%), autologous flap reconstruction occurred in 16 patients (36%), and TE was explanted without replacement in 12 patients (27%). AB - CONCLUSIONS: Infectious complications including cellulitis and abscess formation accounted for most cases requiring reoperation after TE placement for breast reconstruction. More than a quarter of patients who underwent a reoperation ultimately lost their implants. Patients undergoing two-stage expander implant breast reconstruction should be appropriately counseled regarding the possibility of requiring a reoperation in the setting of developing a complication. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001382 PT - Journal Article ID - 10.1097/SAP.0000000000001382 [doi] PP - ppublish LG - English DP - 2018 May EZ - 2018/03/01 06:00 DA - 2018/03/01 06:00 DT - 2018/03/01 06:00 YR - 2018 RD - 20180410 UP - 20180411 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29489547 <517. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29616167 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Negenborn VL AU - Dikmans REG AU - Bouman MB AU - Wilschut JA AU - Mullender MG AU - Salzberg CA FA - Negenborn, Vera L FA - Dikmans, Rieky E G FA - Bouman, Mark-Bram FA - Wilschut, Janneke A FA - Mullender, Margriet G FA - Salzberg, C Andrew IN - Negenborn, Vera L. Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. IN - Dikmans, Rieky E G. Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. IN - Bouman, Mark-Bram. Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. IN - Wilschut, Janneke A. Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. IN - Mullender, Margriet G. Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. IN - Salzberg, C Andrew. Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research Amsterdam, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands; MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Medical System, New York, N.Y. TI - Patient-reported Outcomes after ADM-assisted Implant-based Breast Reconstruction: A Cross-sectional Study. SO - Plastic and Reconstructive Surgery - Global Open. 6(2):e1654, 2018 Feb AS - Plast. reconstr. surg., Glob. open. 6(2):e1654, 2018 Feb NJ - Plastic and reconstructive surgery. Global open VO - 6 IP - 2 PG - e1654 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Background: Although the use of acellular dermal matrices (ADMs) in implant-based reconstruction increases, there is a lack of studies evaluating patient-reported outcome measures after this reconstruction method. We aim to evaluate the patient satisfaction after ADM-assisted implant-based breast reconstruction (IBBR) in 1 of the largest series of patients undergoing ADM-assisted IBBR. AB - Methods: Patients with ADM-assisted IBBR were invited to fill out the BREAST-Q, a validated and standardized questionnaire to measure patient satisfaction after a breast reconstruction. A retrospective chart review was performed to identify patient and surgical characteristics. AB - Results: In total, 208 patients (38.4%) responded and reported a mean satisfaction of 70.6+/-20.2 with their breasts and 78.0+/-20.5 with the outcome. An overall complication rate of 7.7% was noted, with 1.5% severe complications leading to hospital readmission (0.5%) and implant removal (0.5%). Patients with complications and unilateral reconstruction for oncological reasons reported overall less satisfaction rates compared with patients with bilateral, preventive surgery, and an uncomplicated postoperative course. Strongly related domains indicate the importance of patient satisfaction with their breasts and outcome on psychosocial and sexual functioning and satisfaction with information on satisfaction with breasts, outcome, and surgeon. AB - Conclusion: There is an increased demand for patient-reported outcome measures in a changing practice to which the opinion of the patient assumes a larger role. With high satisfaction rates, ADM-assisted IBBR is a valuable reconstruction method, provided that complication rates remain low. Hence, it should only be performed in a selected group of women. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001654 PT - Journal Article ID - 10.1097/GOX.0000000000001654 [doi] ID - PMC5865927 [pmc] PP - epublish PH - 2017/11/21 [received] PH - 2017/12/05 [accepted] LG - English EP - 20180208 DP - 2018 Feb EZ - 2018/04/05 06:00 DA - 2018/04/05 06:01 DT - 2018/04/05 06:00 YR - 2018 RD - 20180408 UP - 20180409 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29616167 <518. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28727237 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - James J AU - Corrigan B AU - Saunders C FA - James, Justin FA - Corrigan, Brigid FA - Saunders, Christobel IN - James, Justin. Department of General Surgery, Royal Perth Hospital, Perth, Western Australia, Australia. IN - James, Justin. Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia. IN - Corrigan, Brigid. Department of General Surgery, Royal Perth Hospital, Perth, Western Australia, Australia. IN - Corrigan, Brigid. Department of Plastic and Reconstructive Surgery, Fiona Stanley Hospital, Perth, Western Australia, Australia. IN - Saunders, Christobel. Department of General Surgery, Royal Perth Hospital, Perth, Western Australia, Australia. IN - Saunders, Christobel. School of Surgery, The University of Western Australia, Harry Perkins Institute of Medical Research, Fiona Stanley Hospital, Perth, Western Australia, Australia. TI - Pre-hydrated sterile acellular dermal matrix allograft in breast reconstruction: review of a single unit's experience. SO - ANZ Journal of Surgery. 88(4):369-373, 2018 Apr AS - ANZ J Surg. 88(4):369-373, 2018 Apr NJ - ANZ journal of surgery VO - 88 IP - 4 PG - 369-373 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dze, 101086634 IO - ANZ J Surg CP - Australia KW - acellular dermal matrix; breast reconstruction; red breast syndrome AB - BACKGROUND: The acellular dermal matrix (Flex HD) (FHD) became available for use in Western Australia in 2014 to aid prosthetic breast reconstruction and this descriptive study aims to review and discuss a single institution's experience since its introduction. AB - METHODS: By retrospective case note, review data were collected for all patients who underwent prosthetic breast reconstruction with the aid of FHD between January 2014 and August 2015 in our institution. Data on basic demographic parameters, risk factors, surgery-related factors, post-operative factors and follow-up information were collected. All complications were recorded and described in detail. AB - RESULTS: FHD was used in 42 breast reconstructions in 26 patients. Procedure-related complications were seen in 26% (n=11) of cases. A major complication requiring return to theatre was seen in 11% (n=5) of cases. Cellulitis of the reconstructed breast (red breast syndrome) was seen in 16.67% (n=7) cases. Overall implant loss was 2.4% (n=1). Of the six possible risk factors for any complication, only current smoking was found to increase the risk of complications (odds ratio=9.667, 95% confidence interval=1.429-65.377). AB - CONCLUSION: FHD is associated with a relatively high overall complication rate. Use of this optional expensive material has to be carefully selected balancing its perceived advantages against this possible risk. The red breast syndrome merits further studies considering its frequent occurrence with FHD use. Copyright © 2017 Royal Australasian College of Surgeons. ES - 1445-2197 IL - 1445-1433 DO - https://dx.doi.org/10.1111/ans.13857 PT - Journal Article ID - 10.1111/ans.13857 [doi] PP - ppublish PH - 2016/06/24 [received] PH - 2016/10/24 [revised] PH - 2016/10/25 [accepted] LG - English EP - 20170720 DP - 2018 Apr EZ - 2017/07/21 06:00 DA - 2017/07/21 06:00 DT - 2017/07/21 06:00 YR - 2018 RD - 20180403 UP - 20180403 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28727237 <519. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29569868 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Bohac M AU - Danisovic L AU - Koller J AU - Dragunova J AU - Varga I FA - Bohac, Martin FA - Danisovic, Lubos FA - Koller, Jan FA - Dragunova, Jana FA - Varga, Ivan IN - Bohac, Martin. Comenius University and University Hospital Bratislava, Department of Plastic Surgery. bohac.md@gmail.com. TI - What happens to an acellular dermal matrix after implantation in the human body? A histological and electron microscopic study. SO - European Journal of Histochemistry. 62(1):2873, 2018 Jan 22 AS - Eur J Histochem. 62(1):2873, 2018 Jan 22 NJ - European journal of histochemistry : EJH VO - 62 IP - 1 PG - 2873 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - bal, 9207930 IO - Eur J Histochem CP - Italy KW - Acellular dermal matrix; breast reconstruction; histology. AB - Acellular matrices are used for various purposes and they have been studied extensively for their potential roles in regenerating tissues or organs. The acellular matrix generates physiological cues that mimic the native tissue microenvironment. Acellular dermal matrix (ADM) is a soft connective tissue graft generated by a decellularization process that preserves the intact extracellular skin matrix. Upon implantation, this structure serves as a scaffold for donor-side cells to facilitate subsequent incorporation and revascularization. In breast reconstruction, ADM is used mainly for lower pole coverage and the shaping of a new breast. It helps control the positioning of the implant in the inframammary fold, and prevent the formation of contractile pseudocapsule around the breast implant. In this study, we provide a comprehensive histological description of ADM used for human breast reconstruction over the course of several months following implementation. Using immunohistochemical methods (a panel of 12 antibodies) coupled with optical and transmission electron microscopy, we confirmed that the original acellular dermal matrix became recolonized by fibroblasts and myofibroblasts, and also by various other free cells of the connective tissue (lymphocytes, macrophages and multinucleated giant cells, granulocytes, mast cells) after implantation into the patient's body. Within the implanted ADM, there was a relatively rapid ingrowth of blood vessels. Lymphatic vessels were only detected in one case 9 months after the implantation of the ADM. These results suggest that lymphangiogenesis is a longer process than angiogenesis. ES - 2038-8306 IL - 1121-760X DO - https://dx.doi.org/10.4081/ejh.2018.2873 PT - Journal Article ID - 10.4081/ejh.2018.2873 [doi] ID - PMC5806504 [pmc] PP - epublish PH - 2017/11/14 [received] PH - 2018/01/03 [accepted] PH - 2017/12/27 [revised] LG - English EP - 20180122 DP - 2018 Jan 22 EZ - 2018/03/24 06:00 DA - 2018/03/24 06:00 DT - 2018/03/24 06:00 YR - 2018 RD - 20180325 UP - 20180326 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29569868 <520. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29320921 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Hallberg H AU - Rafnsdottir S AU - Selvaggi G AU - Strandell A AU - Samuelsson O AU - Stadig I AU - Svanberg T AU - Hansson E AU - Lewin R FA - Hallberg, Hakan FA - Rafnsdottir, Svanheidur FA - Selvaggi, Gennaro FA - Strandell, Annika FA - Samuelsson, Ola FA - Stadig, Ida FA - Svanberg, Therese FA - Hansson, Emma FA - Lewin, Richard IN - Hallberg, Hakan. a Department of clinical sciences , University of Gothenburg, The Sahlgrenska Academy , Gothenburg , Sweden. IN - Hallberg, Hakan. b Department of Reconstructive Plastic Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden. IN - Rafnsdottir, Svanheidur. a Department of clinical sciences , University of Gothenburg, The Sahlgrenska Academy , Gothenburg , Sweden. IN - Rafnsdottir, Svanheidur. c Department of Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden. IN - Selvaggi, Gennaro. a Department of clinical sciences , University of Gothenburg, The Sahlgrenska Academy , Gothenburg , Sweden. IN - Selvaggi, Gennaro. b Department of Reconstructive Plastic Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden. IN - Strandell, Annika. d Health Technology Assessment centre , Region Vastra Gotaland , Gothenburg , Sweden. IN - Samuelsson, Ola. d Health Technology Assessment centre , Region Vastra Gotaland , Gothenburg , Sweden. IN - Stadig, Ida. e Medical Library , Sahlgrenska University Hospital , Gothenburg , Sweden. IN - Svanberg, Therese. d Health Technology Assessment centre , Region Vastra Gotaland , Gothenburg , Sweden. IN - Hansson, Emma. a Department of clinical sciences , University of Gothenburg, The Sahlgrenska Academy , Gothenburg , Sweden. IN - Hansson, Emma. b Department of Reconstructive Plastic Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden. IN - Lewin, Richard. a Department of clinical sciences , University of Gothenburg, The Sahlgrenska Academy , Gothenburg , Sweden. IN - Lewin, Richard. b Department of Reconstructive Plastic Surgery , Sahlgrenska University Hospital , Gothenburg , Sweden. TI - Benefits and risks with acellular dermal matrix (ADM) and mesh support in immediate breast reconstruction: a systematic review and meta-analysis. SO - Journal of Plastic Surgery and Hand Surgery. 52(3):130-147, 2018 Jun AS - J Plast Surg Hand Surg. 52(3):130-147, 2018 Jun NJ - Journal of plastic surgery and hand surgery VO - 52 IP - 3 PG - 130-147 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg CP - Sweden KW - ADM; Breast reconstruction; aceullar dermal matrix; implant; matrix; mesh; systematic review; tissue expander AB - In modern implant-based immediate breast reconstruction, it has become common to use biological acellular dermal and synthetic matrices in combination with a tissue expander or an implant. The aim of this systematic review was to examine differences in recurrence of cancer, impact on oncological treatment, health related quality of life, complications and aesthetic outcome between matrix and no matrix in immediate breast reconstruction. Systematic searches, data extraction and assessment of methodological quality were performed according to predetermined criteria. Fifty-one studies were eligible and included in the review. The certainty of evidence for overall complication rate and implant loss is low (GRADE ). The certainty of evidence for delay of adjuvant treatment, implant loss, infection, capsular contraction and aesthetic outcome is very low (GRADE ). No study reported data on recurrence of cancer or health related quality of life. In conclusion, there is a lack of high quality studies that compare the use of matrix with no matrix in immediate breast reconstruction. Specifically, there are no data on risk of recurrence of cancer, delay of adjuvant treatment and Health related quality of life (HRQoL). In addition, there is a risk of bias in many studies. It is often unclear what complications have been included and how they have been diagnosed, and how and when capsular contracture and aesthetic outcome have been evaluated. Controlled trials that further analyse the impact of radiotherapy, type of matrix and type of procedure (one or two stages) are necessary. ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.1080/2000656X.2017.1419141 PT - Journal Article ID - 10.1080/2000656X.2017.1419141 [doi] PP - ppublish LG - English EP - 20180110 DP - 2018 Jun EZ - 2018/01/13 06:00 DA - 2018/01/13 06:00 DT - 2018/01/12 06:00 YR - 2018 RD - 20180314 UP - 20180314 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29320921 <521. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28854828 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Hammer-Hansen N AU - Juhl AA AU - Damsgaard TE FA - Hammer-Hansen, Niels FA - Juhl, Alexander Andersen FA - Damsgaard, Tine Engberg IN - Hammer-Hansen, Niels. a Plastic Surgery Research Unit, Department of Plastic and Breast Surgery , Aarhus University Hospital , Aarhus , Denmark. IN - Juhl, Alexander Andersen. a Plastic Surgery Research Unit, Department of Plastic and Breast Surgery , Aarhus University Hospital , Aarhus , Denmark. IN - Damsgaard, Tine Engberg. a Plastic Surgery Research Unit, Department of Plastic and Breast Surgery , Aarhus University Hospital , Aarhus , Denmark. TI - Laser-assisted indocyanine green angiography in implant-based immediate breast reconstruction: a retrospective study. SO - Journal of Plastic Surgery and Hand Surgery. 52(3):158-162, 2018 Jun AS - J Plast Surg Hand Surg. 52(3):158-162, 2018 Jun NJ - Journal of plastic surgery and hand surgery VO - 52 IP - 3 PG - 158-162 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg CP - Sweden KW - Fluorescence angiography; SPY; acellular dermal matrix; breast reconstruction; indocyanine green; necrosis AB - OBJECTIVE: Necrosis in implant-based immediate breast reconstruction is a feared complication. Accurate evaluation of mastectomy skin flaps per-operatively is necessary to decrease this risk. The present study is the first in Scandinavia to review the effects of perioperative evaluation with laser-assisted indocyanine green fluorescence angiography (LA-ICGA). AB - METHOD: A retrospective review was performed using data from the electronic patient record at the Department of Plastic and Breast Surgery at Aarhus University Hospital in Denmark on all patients who underwent implant-based skin-sparing immediate breast reconstruction with ADM in the time period March 2012 to October 2015. A total of 92 patients undergoing 128 breasts reconstructions were included in the study. An evaluation of complications before and after the implementation of LA-ICGA was performed. AB - RESULTS: No significant difference in necrosis rates requiring surgical revision (p=.411) or conservative treatment (p=.149) in patients undergoing implant-based immediate breast reconstruction were found. AB - CONCLUSION: Our results differ from previously published studies in that no beneficial effect on necrosis rates of was found after implementing LA-ICGA, possibly due to our limited sample size. ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.1080/2000656X.2017.1372289 PT - Journal Article ID - 10.1080/2000656X.2017.1372289 [doi] PP - ppublish LG - English EP - 20170830 DP - 2018 Jun EZ - 2017/09/01 06:00 DA - 2017/09/01 06:00 DT - 2017/09/01 06:00 YR - 2018 RD - 20180314 UP - 20180314 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28854828 <522. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29511877 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Park TH AU - Chung SW AU - Song SY AU - Lew DH AU - Roh TS AU - Lee DW FA - Park, Tae Hwan FA - Chung, Soon Won FA - Song, Seung Yong FA - Lew, Dae Hyun FA - Roh, Tai Suk FA - Lee, Dong Won IN - Park, Tae Hwan. Department of Plastic and Reconstructive Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. IN - Chung, Soon Won. Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. IN - Song, Seung Yong. Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. IN - Lew, Dae Hyun. Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. IN - Roh, Tai Suk. Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. IN - Lee, Dong Won. Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. psleedw@gmail.com. TI - The use of acellular dermal matrix in immediate two-stage prosthetic breast reconstruction provides protection from postmastectomy radiation therapy: a clinicopathologic perspective. SO - Journal of Materials Science-Materials in Medicine. 29(3):27, 2018 Mar 06 AS - J. mater. sci., Mater. med.. 29(3):27, 2018 Mar 06 NJ - Journal of materials science. Materials in medicine VO - 29 IP - 3 PG - 27 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 9013087 IO - J Mater Sci Mater Med CP - United States AB - Although there is ample evidence showing that radiation therapy increases the risk of complications of breast reconstruction, the efficacy of human acellular dermal matrix (CGCryoDerm) in immediate tissue expander breast reconstruction in the setting of postmastectomy radiation therapy has not been fully elucidated. In this study, we report our institutional experience with pertinent refined surgical technique, and determine whether acellular dermal matrices have a protective effect in this increasingly prevalent clinical setting. Twenty-six patients who underwent immediate two-stage breast reconstruction in the setting of postmastectomy radiation therapy with at least 2 years of follow-up were retrieved. Fifteen patents were reconstructed with ADM, whereas 11 patients were reconstructed without ADM. The occurrence of complications was assessed according to the reconstruction type (with ADM vs without ADM). Furthermore, in patients reconstructed with ADM (n=15), immunohistochemistry was performed to analyze the breast capsule with ADM compared with that without ADM in the same patient, according to the expression of alpha-smooth muscle actin (alpha-SMA). The occurrence of complications was significantly associated with the reconstruction type (with ADM vs. without ADM, p = 0.015). On the basis of the results of alpha-SMA staining, alpha-SMA+ myofibroblasts were relatively highly expressed throughout the breast capsule without ADM. On the contrary, alpha-SMA+ myofibroblasts present at the breast capsule adjacent to the ADM were scarce and irregularly scattered. Use of an acellular dermal matrix may be recommended to patients who are concerned about complications after immediate two-stage breast reconstruction in the setting of postmastectomy radiation therapy. ES - 1573-4838 IL - 0957-4530 DO - https://dx.doi.org/10.1007/s10856-018-6036-6 PT - Journal Article ID - 10.1007/s10856-018-6036-6 [doi] ID - 10.1007/s10856-018-6036-6 [pii] PP - epublish PH - 2017/08/29 [received] PH - 2018/02/09 [accepted] LG - English EP - 20180306 DP - 2018 Mar 06 EZ - 2018/03/08 06:00 DA - 2018/03/08 06:00 DT - 2018/03/08 06:00 YR - 2018 RD - 20180312 UP - 20180312 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29511877 <523. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 19342990 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Losken A FA - Losken, Albert IN - Losken, Albert. Emory Division of Plastic and Reconstructive Surgery, Emory University School of Medicine, Atlanta GA. TI - Early Results Using Sterilized Acellular Human Dermis (Neoform) in Post-Mastectomy Tissue Expander Breast Reconstruction. SO - Plastic & Reconstructive Surgery. 123(6):1654-1658, 2009 06 AS - Plast Reconstr Surg. 123(6):1654-1658, 2009 06 NJ - Plastic and reconstructive surgery VO - 123 IP - 6 PG - 1654-1658 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - Acellular dermal products play a beneficial role in immediate tissue expander breast reconstruction. They provide improved coverage and support in the lower pole, allowing the pectoralis muscle to drape over most of the expander and maximize lower pole expansion. Tissue incorporation is desired without any adverse affects on recovery. The purpose of this series is to evaluate the early safety and morbidity of preserved human allograft dermis sterilized using the Tutoplast(R) process.All patients who underwent tissue expander reconstruction with NeoForm(R) at Emory University Hospital between 6/07 and 4/08 were included in the series. Patient demographics, risk factors, surgical technique, early complications and outcomes were evaluated.Twenty-two consecutive patients were included, with a total of 31 breasts (bilateral n=9, left n=9, right n=4). The average age was 48 years (range: 31-71), with an average body mass index of 26.7 (range: 19-35). Fifteen patients had a diagnosis of invasive breast cancer and 7 patients had DCIS. Risk factors included hypertension n=5, history of smoking n=2, diabetes n=1, and post operative radiation therapy n=8. All reconstructions were immediate with lower pole tissue expanders. NeoForm was rehydrated for appropriately 3-5 minutes. It was sutured superiorly to the lower border of the pectoralis muscle and inferiorly to the inframammary fold. The 4x16 size was used in 18 breasts, and 6x16 cm in 13 breasts. Early post operative complications occurred in one patient with native mastectomy skin necrosis. All drains were removed by the third post-operative week. There were no cases with infection, foreign body reaction, rejection, seromas, or skin erythema. Tissue expansion was performed without any difficult. Expander removal and secondary implant insertion demonstrated adequate incorporation of the NeoForm in 16 patients. Encapsulation of the Neoform, infection or extrusion was not observed.Acellular dermal products have become a useful addition to tissue expander breast reconstruction. NeoForm was successfully used for lower pole coverage of the tissue expander in 31 immediate expander breast reconstructions. Good tissue incorporation was observed clinically and there were no post operative complications that could be related to the NeoForm. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0b013e31819c4337 PT - Journal Article ID - 10.1097/PRS.0b013e31819c4337 [doi] PP - ppublish LG - English EP - 20090323 DP - 2009 06 EZ - 2009/04/04 09:00 DA - 2009/04/04 09:00 DT - 2009/04/04 09:00 YR - 2009 RD - 20180312 UP - 20180312 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=19342990 <524. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29368031 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Lee KT AU - Eom Y AU - Mun GH AU - Bang SI AU - Jeon BJ AU - Pyon JK FA - Lee, Kyeong-Tae FA - Eom, Yeseul FA - Mun, Goo-Hyun FA - Bang, Sa Ik FA - Jeon, Byung-Joon FA - Pyon, Jai-Kyong IN - Lee, Kyeong-Tae. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, South Korea. IN - Eom, Yeseul. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, South Korea. IN - Mun, Goo-Hyun. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, South Korea. IN - Bang, Sa Ik. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, South Korea. IN - Jeon, Byung-Joon. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, South Korea. IN - Pyon, Jai-Kyong. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, South Korea. pspriest.pyon@samsung.com. TI - Efficacy of Partial- Versus Full-Sling Acellular Dermal Matrix Use in Implant-Based Breast Reconstruction: A Head-to-Head Comparison. SO - Aesthetic Plastic Surgery. 42(2):422-433, 2018 Apr AS - Aesthetic Plast Surg. 42(2):422-433, 2018 Apr NJ - Aesthetic plastic surgery VO - 42 IP - 2 PG - 422-433 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Acellular dermal matrix; Breast reconstruction; Implant; Malposition; Pectoralis major muscle; Rippling; Tissue expander AB - BACKGROUND: Acellular dermal matrix (ADM), popularly used in tissue expander-based breast reconstruction, is applied either as a partial or full sling, but without any consensus regarding which method of application produces better outcomes. We aimed to compare the outcomes between two patient groups who underwent tissue expander-based breast reconstruction using these techniques. AB - METHODS: A retrospective review was conducted for consecutive patients who underwent immediate two-stage implant-based breast reconstruction using ADM between January 2013 and June 2016. They were categorized into two cohorts: cohort 1 included patients in whom ADM was applied using the partial-sling technique, insetting it obliquely after releasing the pectoralis major muscle from its costal origin, and cohort 2 included those who underwent a full-sling technique, insetting it transversely after releasing the muscle from its costal and lower sternal origin. Postoperative complications and aesthetic outcomes were compared between the two groups. AB - RESULTS: We analysed 329 cases (167 in cohort 1 and 162 in cohort 2) with similar baseline characteristics in both cohorts. Reconstruction failure occurred in 2.4% of overall patients. The rates of each and overall acute complications did not differ significantly between the cohorts. Cohort 2 showed significantly lower rates of tissue expander displacement and malposition following the first-stage operation and rippling following the second-stage operation, differences that retained the influences in multivariate analyses. Higher aesthetic scores were obtained in cohort 2. AB - CONCLUSION: Using the full-sling ADM might reduce unintended migration of prostheses and enable proper tissue expansion, resulting in better overall outcomes without increasing morbidities. AB - LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-018-1084-3 PT - Journal Article ID - 10.1007/s00266-018-1084-3 [doi] ID - 10.1007/s00266-018-1084-3 [pii] PP - ppublish PH - 2017/09/29 [received] PH - 2018/01/15 [accepted] LG - English EP - 20180124 DP - 2018 Apr EZ - 2018/01/26 06:00 DA - 2018/01/26 06:00 DT - 2018/01/26 06:00 YR - 2018 RD - 20180307 UP - 20180307 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29368031 <525. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29302735 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Folli S AU - Curcio A AU - Melandri D AU - Bondioli E AU - Rocco N AU - Catanuto G AU - Falcini F AU - Purpura V AU - Mingozzi M AU - Buggi F AU - Marongiu F AI - Rocco, Nicola; ORCID: http://orcid.org/0000-0001-6941-7873 FA - Folli, Secondo FA - Curcio, Annalisa FA - Melandri, Davide FA - Bondioli, Elena FA - Rocco, Nicola FA - Catanuto, Giuseppe FA - Falcini, Fabio FA - Purpura, Valeria FA - Mingozzi, Matteo FA - Buggi, Federico FA - Marongiu, Francesco IN - Folli, Secondo. Department of Breast Surgery, Plastic and Reconstructive Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori Milano, Via Venezian 1, 20133, Milan, Italy. IN - Curcio, Annalisa. Breast Surgical Unit, Morgagni - Pierantoni Hospital, 47100, Forli, Italy. IN - Melandri, Davide. Burns Intensive Care Unit and "Regione Emilia Romagna" Skin Bank, "M.Bufalini" Hospital, Cesena, Italy. IN - Bondioli, Elena. Burns Intensive Care Unit and "Regione Emilia Romagna" Skin Bank, "M.Bufalini" Hospital, Cesena, Italy. IN - Rocco, Nicola. Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via S.Pansini 5, 80131, Naples, Italy. nicolarocco2003@gmail.com. IN - Rocco, Nicola. G.RE.T.A. Group for Recontructive and Therapeutic Advancements, Milan, Naples, Catania, Italy. nicolarocco2003@gmail.com. IN - Catanuto, Giuseppe. G.RE.T.A. Group for Recontructive and Therapeutic Advancements, Milan, Naples, Catania, Italy. IN - Catanuto, Giuseppe. Multidisciplinary Breast Unit, Azienda Ospedaliera Cannizzaro, Catania, Italy. IN - Falcini, Fabio. Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola, Forli, Italy. IN - Falcini, Fabio. Azienda USL della Romagna, Forli, Italy. IN - Purpura, Valeria. Burns Intensive Care Unit and "Regione Emilia Romagna" Skin Bank, "M.Bufalini" Hospital, Cesena, Italy. IN - Mingozzi, Matteo. Breast Surgical Unit, Morgagni - Pierantoni Hospital, 47100, Forli, Italy. IN - Buggi, Federico. Breast Surgical Unit, Morgagni - Pierantoni Hospital, 47100, Forli, Italy. IN - Marongiu, Francesco. Breast Surgical Unit, Morgagni - Pierantoni Hospital, 47100, Forli, Italy. TI - A New Human-Derived Acellular Dermal Matrix for Breast Reconstruction Available for the European Market: Preliminary Results. SO - Aesthetic Plastic Surgery. 42(2):434-441, 2018 Apr AS - Aesthetic Plast Surg. 42(2):434-441, 2018 Apr NJ - Aesthetic plastic surgery VO - 42 IP - 2 PG - 434-441 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Acellular dermal matrices; Alloplastic tissue; Breast implants; Breast reconstruction; Human acellular dermal matrices AB - INTRODUCTION: The introduction of acellular dermal matrices (ADMs) contributed to the growing diffusion of direct-to-implant breast reconstruction (DTI-BR) following mastectomy for breast cancer. According to specific legislations, European specialists could not benefit from the use of human-derived ADMs, even though most evidence in the literature are available for this kind of device, showed optimal outcomes in breast reconstruction. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of a new human cadaver-donor-derived ADM (named with the Italian acronym, MODA, for matrice omologa dermica acellulata) from the Italian National Transplant Center and National Health Institute. We report preliminary results of MODA application in direct-to-implant breast reconstruction following nipple-areola complex (NAC)-sparing mastectomy for breast cancer treatment. AB - MATERIALS AND METHODS: We prospectively enrolled all women undergoing NAC-sparing mastectomy for breast cancer and DTI-BR in our breast surgical unit from June 2015 to January 2017. We enrolled a selected population without previous chest wall irradiation, not being heavy tobacco smokers or diabetic, with a BMI < 30 kg/m² and requiring less than 550 cc silicone implants. We assessed short-term outcomes, defined as postoperative complications presenting in the first 30 postoperative days and long-term outcomes at 6 and 12 months. AB - RESULTS: From June 2015 to January 2017, we treated 56 breasts. At a mean follow-up of 14 months, we observed only two minor complications described as limited wound dehiscences, conservatively managed with complete resolution without implant exposure or re-intervention. AB - CONCLUSIONS: Our preliminary results show very good performance of MODA in direct-to-implant breast reconstruction following NAC-sparing mastectomy for breast cancer treatment. This is particularly relevant for the European market, where no other human-derived devices are available for breast reconstruction due to regulatory restrictions. AB - LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-1069-7 PT - Journal Article ID - 10.1007/s00266-017-1069-7 [doi] ID - 10.1007/s00266-017-1069-7 [pii] PP - ppublish PH - 2017/09/27 [received] PH - 2017/12/20 [accepted] LG - English EP - 20180104 DP - 2018 Apr EZ - 2018/01/06 06:00 DA - 2018/01/06 06:00 DT - 2018/01/06 06:00 YR - 2018 RD - 20180307 UP - 20180307 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29302735 <526. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28763153 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Nadeem R AI - Nadeem, Rana; ORCID: http://orcid.org/0000-0002-4070-3689 FA - Nadeem, Rana IN - Nadeem, Rana. Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK. TI - Prepectoral implant-based breast reconstruction; complete acellular dermal matrix wrap or anterior circumferential cover. SO - Breast Journal. 24(2):223-224, 2018 Mar AS - Breast J. 24(2):223-224, 2018 Mar NJ - The breast journal VO - 24 IP - 2 PG - 223-224 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J CP - United States ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12881 PT - Letter ID - 10.1111/tbj.12881 [doi] PP - ppublish PH - 2017/05/27 [received] PH - 2017/06/13 [accepted] LG - English EP - 20170801 DP - 2018 Mar EZ - 2017/08/02 06:00 DA - 2017/08/02 06:00 DT - 2017/08/02 06:00 YR - 2018 RD - 20180306 UP - 20180306 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28763153 <527. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28703387 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Maruccia M AU - Di Taranto G AU - Onesti MG FA - Maruccia, Michele FA - Di Taranto, Giuseppe FA - Onesti, Maria G IN - Maruccia, Michele. Department of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. IN - Di Taranto, Giuseppe. Department of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. IN - Onesti, Maria G. Department of Plastic and Reconstructive Surgery, Sapienza University, Rome, Italy. TI - One-stage muscle-sparing breast reconstruction in elderly patients: A new tool for retaining excellent quality of life. SO - Breast Journal. 24(2):180-183, 2018 Mar AS - Breast J. 24(2):180-183, 2018 Mar NJ - The breast journal VO - 24 IP - 2 PG - 180-183 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J CP - United States KW - acellular dermal matrix; breast cancer; breast reconstruction; elderly patient; muscle-sparing technique; quality of life AB - More than 50% of breast cancer care occurs in elderly but women aged 65 and over generally have lower breast reconstruction (BR) rates. In medical literature, few papers focused on BR in elderly patients and usually the reported techniques are multisteps such as expander-implant reconstruction, local, and free flaps. We present a one-stage reconstruction technique employed in elderly patients: muscle-sparing immediate BR with subcutaneous implant and Braxon acellular dermal matrix. We prove the feasibility and safety of the technique and believe that this new procedure could represent a potential benefit in elderly BR. Copyright © 2017 Wiley Periodicals, Inc. ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12860 PT - Journal Article ID - 10.1111/tbj.12860 [doi] PP - ppublish PH - 2016/06/14 [received] PH - 2016/10/17 [revised] PH - 2016/10/18 [accepted] LG - English EP - 20170713 DP - 2018 Mar EZ - 2017/07/14 06:00 DA - 2017/07/14 06:00 DT - 2017/07/14 06:00 YR - 2018 RD - 20180306 UP - 20180306 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28703387 <528. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28812172 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Bohac M AU - Varga I AU - Polak S AU - Dragunova J AU - Fedeles J Sr. AU - Koller J AI - Bohac, Martin; ORCID: http://orcid.org/0000-0003-4625-1326 FA - Bohac, Martin FA - Varga, Ivan FA - Polak, Stefan FA - Dragunova, Jana FA - Fedeles, Jozef Sr. FA - Koller, Jan IN - Bohac, Martin. Department of Plastic Surgery, Faculty of Medicine, University Hospital Bratislava, Comenius University in Bratislava, Ruzinovska 6, 826 06, Bratislava, Slovakia. bohac.md@gmail.com. IN - Bohac, Martin. Regenmed Ltd., Medena 29, 811 02, Bratislava, Slovakia. bohac.md@gmail.com. IN - Varga, Ivan. Faculty of Medicine, Institute of Histology and Embryology, Comenius University in Bratislava, Sasinkova 4, 811 08, Bratislava, Slovakia. IN - Polak, Stefan. Faculty of Medicine, Institute of Histology and Embryology, Comenius University in Bratislava, Sasinkova 4, 811 08, Bratislava, Slovakia. IN - Dragunova, Jana. Department of Burns and Reconstructive Surgery, Faculty of Medicine, University Hospital Bratislava, Comenius University in Bratislava, Bratislava, Slovakia. IN - Fedeles, Jozef Sr.. Department of Plastic Surgery, Faculty of Medicine, University Hospital Bratislava, Comenius University in Bratislava, Ruzinovska 6, 826 06, Bratislava, Slovakia. IN - Koller, Jan. Department of Burns and Reconstructive Surgery, Faculty of Medicine, University Hospital Bratislava, Comenius University in Bratislava, Bratislava, Slovakia. TI - Delayed post mastectomy breast reconstructions with allogeneic acellular dermal matrix prepared by a new decellularizationmethod. SO - Cell & Tissue Banking. 19(1):61-68, 2018 Mar AS - Cell Tissue Bank. 19(1):61-68, 2018 Mar NJ - Cell and tissue banking VO - 19 IP - 1 PG - 61-68 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100965121 IO - Cell Tissue Bank CP - Netherlands KW - A cellular dermal matrix; Breast reconstruction; Tissue expander AB - Acellular dermal matrix (ADM) is a tissue graft of allogeneic origin from post-mortem tissue donors prepared by an innovative decellularization process. The newly developed non-toxic and low cost decellularization process of cadaver origin dermis included ADM in breast reconstruction procedures proved to help coverage of the lower-pole of breast expanders or implants. As the results have shown, it did help to eliminate autologous dermis donor site morbidity along with shortening the operation time by avoiding elevation of additional muscle or fascia during the operation. Main aims of this article include histology evaluation of allogeneic acellular dermal matrix prepared by a new decellularization method and presentation of clinical results of its use. A total of 22 patients underwent 26 ADM based breast reconstructions. The mean patient's follow up was 12.6 months. Average total size of ADM used for one breast was 273 cm². Post-operative complications occurred in 3 patients including one expander infection, one expander extrusion and one expander pocket disfiguration. Microscopic analysis of tissue samples has confirmed incorporation of the acellular dermal matrices into the surrounding connective tissue without any noticeable immune reaction. In a majority of the ADM samples we found pseudocapsullar formation on implant side of samples without acute or chronic inflammatory cells. The use of ADM prepared by new preparation method in expansive post mastectomy breast reconstruction was associated by a relatively low complication rate resulting in good outcomes. ES - 1573-6814 IL - 1389-9333 DO - https://dx.doi.org/10.1007/s10561-017-9655-0 PT - Journal Article ID - 10.1007/s10561-017-9655-0 [doi] ID - 10.1007/s10561-017-9655-0 [pii] PP - ppublish PH - 2017/05/25 [received] PH - 2017/08/08 [accepted] SI - ClinicalTrials.gov SA - ClinicalTrials.gov/NCT02835781 SL - https://clinicaltrials.gov/search/term=NCT02835781 GI - No: 1/0297/14 Organization: *Slovak Ministry of Education. VEGA* GI - No: No. 1/0271/17 Organization: *Slovak Ministry of Education,VEGA* LG - English EP - 20170816 DP - 2018 Mar EZ - 2017/08/16 06:00 DA - 2017/08/16 06:00 DT - 2017/08/17 06:00 YR - 2018 RD - 20180228 UP - 20180228 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28812172 <529. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29481412 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Gougoutas AJ AU - Said HK AU - Um G AU - Chapin A AU - Mathes DW FA - Gougoutas, Alexander J FA - Said, Hakim K FA - Um, Grace FA - Chapin, Anne FA - Mathes, David W IN - Gougoutas, Alexander J. Seattle, Wash.; and Denver, Colo. From the Center for Reconstructive Surgery, University of Washington Medical Center; and the University of Colorado Hospital, University of Colorado. TI - Nipple-Areola Complex Reconstruction. SO - Plastic & Reconstructive Surgery. 141(3):404e-416e, 2018 Mar AS - Plast Reconstr Surg. 141(3):404e-416e, 2018 Mar NJ - Plastic and reconstructive surgery VO - 141 IP - 3 PG - 404e-416e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand how to determine nipple-areola complex positioning on the reconstructed breast. 2. Understand the multitude of local flap and distant graft options for nipple-areola complex reconstruction. 3. Draw at least three fundamental nipple-areola complex reconstruction patterns. 4. Understand the forces that are responsible for flattening of the reconstructed papule. 5. Understand the current techniques used in secondary nipple-areola complex reconstructions. AB - SUMMARY: Nipple-areola complex reconstruction and tattooing represent the final two stages of breast reconstruction. Nipple-areola complex reconstruction is typically accomplished with the use of local flaps, local flaps with augmentation grafts, or a combination thereof. Regardless of the technique used, however, all nipple-areola complex reconstructions lose a degree of projection over time. Options for secondary reconstruction include the use of local tissue flaps alone or in combination with acellular biological matrices. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004166 PT - Journal Article ID - 10.1097/PRS.0000000000004166 [doi] ID - 00006534-201803000-00040 [pii] PP - ppublish LG - English DP - 2018 Mar EZ - 2018/02/27 06:00 DA - 2018/02/27 06:00 DT - 2018/02/27 06:00 YR - 2018 RD - 20180226 UP - 20180227 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29481412 <530. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29481386 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Sobti N AU - Ji E AU - Brown RL AU - Cetrulo CL Jr. AU - Colwell AS AU - Winograd JM AU - Austen WG Jr. AU - Liao EC FA - Sobti, Nikhil FA - Ji, Emily FA - Brown, Rebecca L FA - Cetrulo, Curtis L Jr. FA - Colwell, Amy S FA - Winograd, Jonathan M FA - Austen, William G Jr. FA - Liao, Eric C IN - Sobti, Nikhil. Boston, Mass. From the Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital. TI - Evaluation of Acellular Dermal Matrix Efficacy in Prosthesis-Based Breast Reconstruction. SO - Plastic & Reconstructive Surgery. 141(3):541-549, 2018 Mar AS - Plast Reconstr Surg. 141(3):541-549, 2018 Mar NJ - Plastic and reconstructive surgery VO - 141 IP - 3 PG - 541-549 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - BACKGROUND: Although many studies have examined the safety of acellular dermal matrix in immediate prosthetic breast reconstruction, few studies have evaluated efficacy. This study examined initial tissue expander fill volume as a marker of efficacy, comparing patients after staged prosthetic breast reconstruction assisted with acellular dermal matrix versus breast reconstruction not assisted with acellular dermal matrix. Number of fill visits and time interval to implant exchange were examined as secondary endpoints. AB - METHODS: An institutional review board-approved retrospective chart review was conducted to identify consecutive staged prosthetic reconstruction cases over 12 years. AB - RESULTS: Mean initial tissue expander fill volume was significantly higher in the acellular dermal matrix group compared with the non-acellular dermal matrix group (180.8 +/- 150.0 versus 45.8 +/- 74.4; p = 0.00). Normalizing for final implant size, the acellular dermal matrix group exhibited significantly higher perioperative fill (0.33 +/- 0.24 versus 0.11 +/- 0.16; p = 0.00). A collinear trend was observed between acellular dermal matrix use and direct-to-implant reconstruction procedures during the study period. AB - CONCLUSIONS: These results suggest that acellular dermal matrix use is more efficacious in achieving greater initial fill volume, fewer visits for expansion, and a shorter time interval to implant exchange compared with non-acellular dermal matrix procedures. The authors also describe a collinear relationship between acellular dermal matrix use and transition to direct-to-implant procedures at their institution. This work serves as a framework for future studies evaluating acellular dermal matrix efficacy, and guides innovation of biomaterials to support breast reconstruction. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004109 PT - Journal Article ID - 10.1097/PRS.0000000000004109 [doi] ID - 00006534-201803000-00001 [pii] PP - ppublish LG - English DP - 2018 Mar EZ - 2018/02/27 06:00 DA - 2018/02/27 06:00 DT - 2018/02/27 06:00 YR - 2018 RD - 20180226 UP - 20180227 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29481386 <531. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29481388 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Checketts JX AU - Gordon J AU - Crawford JH AU - Adams H AU - Duckett L AU - Vassar M FA - Checketts, Jake X FA - Gordon, Joshua FA - Crawford, Julia H FA - Adams, Haley FA - Duckett, Laurie FA - Vassar, Matt IN - Checketts, Jake X. Tulsa and Oklahoma City, Okla. From Oklahoma State University Center for Health Sciences; the Department of Surgery, Oklahoma State University Medical Center; and the Departments of Anesthesiology and Pediatric Endocrinology, University of Oklahoma. TI - Is the Right Research Being Conducted to Advance Knowledge about Breast Reconstruction? An Analysis of the Research Pipeline. SO - Plastic & Reconstructive Surgery. 141(3):566-577, 2018 Mar AS - Plast Reconstr Surg. 141(3):566-577, 2018 Mar NJ - Plastic and reconstructive surgery VO - 141 IP - 3 PG - 566-577 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - BACKGROUND: It has been estimated that up to 85 percent of research is of limited value or wasted, in part because of the wrong research questions being addressed. In this study, the authors identified research gaps for breast reconstruction using guideline recommendations based on low-quality or no evidence. The authors then evaluated whether research was currently being conducted to fill these gaps. AB - METHODS: The authors extracted grade C and D options, which are based on limited evidence, from the American Society of Plastic Surgeon's clinical practice guideline for breast reconstruction. For each option, the authors created Participants, Intervention, Comparator, Outcome questions and search strings using a systematic process. Searches were conducted of ClinicalTrials.gov and the World Health Organization's International Clinical Trials Registry Platform to locate new and ongoing studies. The authors also catalogued studies on breast reconstruction funded by the Plastic Surgery Foundation. AB - RESULTS: Of the 10 research gaps, only six were being addressed by new and ongoing research. Timing of reconstruction (immediate or delayed) and use of acellular dermal matrix were most frequently studied. Preoperative referral of a plastic surgeon before mastectomy, complications associated with preoperative breast size, effects of hormone therapy on postoperative outcomes, and methods for detecting local recurrence after mastectomy were not being addressed by new research. Studies funded by the Plastic Surgery Foundation showed a similar pattern. AB - CONCLUSIONS: Of the areas identified, some have received more attention than others. Gaps remain. The authors' results should spark interest in conducting research on these topics and, by so doing, strengthen the clinical practice guideline recommendations. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004107 PT - Journal Article ID - 10.1097/PRS.0000000000004107 [doi] ID - 00006534-201803000-00003 [pii] PP - ppublish LG - English DP - 2018 Mar EZ - 2018/02/27 06:00 DA - 2018/02/27 06:00 DT - 2018/02/27 06:00 YR - 2018 RD - 20180226 UP - 20180227 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29481388 <532. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29464161 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Heidemann LN AU - Gunnarsson GL AU - Salzberg CA AU - Sorensen JA AU - Thomsen JB FA - Heidemann, Lene Nyhoj FA - Gunnarsson, Gudjon L FA - Salzberg, C Andrew FA - Sorensen, Jens Ahm FA - Thomsen, Jorn Bo IN - Heidemann, Lene Nyhoj. Department of Plastic- and Reconstructive Surgery, Odense University Hospital, Denmark; Department of Plastic Surgery, Telemark Hospital, Skien, Norway; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, N.Y. IN - Gunnarsson, Gudjon L. Department of Plastic- and Reconstructive Surgery, Odense University Hospital, Denmark; Department of Plastic Surgery, Telemark Hospital, Skien, Norway; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, N.Y. IN - Salzberg, C Andrew. Department of Plastic- and Reconstructive Surgery, Odense University Hospital, Denmark; Department of Plastic Surgery, Telemark Hospital, Skien, Norway; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, N.Y. IN - Sorensen, Jens Ahm. Department of Plastic- and Reconstructive Surgery, Odense University Hospital, Denmark; Department of Plastic Surgery, Telemark Hospital, Skien, Norway; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, N.Y. IN - Thomsen, Jorn Bo. Department of Plastic- and Reconstructive Surgery, Odense University Hospital, Denmark; Department of Plastic Surgery, Telemark Hospital, Skien, Norway; and Division of Plastic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, N.Y. TI - Complications following Nipple-Sparing Mastectomy and Immediate Acellular Dermal Matrix Implant-based Breast Reconstruction-A Systematic Review and Meta-analysis. SO - Plastic and Reconstructive Surgery - Global Open. 6(1):e1625, 2018 Jan AS - Plast. reconstr. surg., Glob. open. 6(1):e1625, 2018 Jan NJ - Plastic and reconstructive surgery. Global open VO - 6 IP - 1 PG - e1625 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Background: Acellular dermal matrix was introduced in breast reconstruction in 2001 and is gradually becoming a standard component for immediate breast reconstruction and nipple-sparing mastectomy. The reconstructive technique allows for improved aesthetic outcomes. However, there seems to be uncertainty regarding complication rates. The aim of this review was to systematically evaluate complication rates related to this method. AB - Methods: This systematic review was conducted according to the recommendations outlined in the Cochrane Handbook for reviews and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Relevant databases were searched for in the literature concerning the use of acellular dermal matrix in implant-based nipple-sparing mastectomy and immediate breast reconstruction. All studies underwent detailed quality assessment. Summarized outcome rates were computed using meta-analysis. AB - Results: Nine of 1,039 studies were eligible for inclusion yielding 778 procedures. The quality was acceptable for all included studies. The meta-analysis found the rate of skin necrosis to be 11%, nipple necrosis 5%, infection in 12%, hematoma in 1%, treated seroma in 5%, explantation 4%, and unplanned return to the operating room in 9%. AB - Conclusion: The use of acellular dermal matrix in nipple-sparing mastectomy and implant-based breast reconstruction can be done with acceptable complication rates in selected patients. We recommend future studies to include specific definitions when reporting complication rates. Furthermore, future studies should elaborate on demographic characteristics of the included study samples and include predictor analysis to enhance knowledge of high risk patients. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001625 PT - Journal Article ID - 10.1097/GOX.0000000000001625 [doi] ID - PMC5811291 [pmc] PP - epublish PH - 2017/04/05 [received] PH - 2017/11/08 [accepted] LG - English EP - 20180112 DP - 2018 Jan EZ - 2018/02/22 06:00 DA - 2018/02/22 06:01 DT - 2018/02/22 06:00 YR - 2018 RD - 20180223 UP - 20180223 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29464161 <533. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29464155 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Azzi AJ AU - Zammit D AU - Lessard L FA - Azzi, Alain J FA - Zammit, Dino FA - Lessard, Lucie IN - Azzi, Alain J. Division of Plastic and Reconstructive Surgery, McGill University, Montreal, QC, Canada. IN - Zammit, Dino. Division of Plastic and Reconstructive Surgery, McGill University, Montreal, QC, Canada. IN - Lessard, Lucie. Division of Plastic and Reconstructive Surgery, McGill University, Montreal, QC, Canada. TI - Single-Stage Breast Reconstruction Using an All-In-One Adjustable Expander/Implant. SO - Plastic and Reconstructive Surgery - Global Open. 6(1):e1609, 2018 Jan AS - Plast. reconstr. surg., Glob. open. 6(1):e1609, 2018 Jan NJ - Plastic and reconstructive surgery. Global open VO - 6 IP - 1 PG - e1609 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Background: When tissue expansion is necessary in breast reconstruction, a single-stage approach is possible using adjustable expander/implants, with or without the use of acellular dermal matrix. We aimed to present the senior author's single-stage experience over a period of 12 years using combined expander/implants in breast reconstruction. AB - Methods: This is a Single-institution, retrospective review of breast reconstruction with combined expander/implants from 2002 to 2014. Logistic regression was performed to evaluate the impact of multiple variables on long-term outcomes. AB - Results: A total of 162 implants in 105 patients were included in this study. Mean follow-up time was 81.7 months (SD, +/- 39.2; range, 15-151). Complication rates were as follows: 0.62% extrusion, 1.2% mastectomy flap necrosis, 1.2% hematoma, 1.9% dehiscence, 2.5% seroma, 4.9% infection, and 15.4% deflation. The following associations were identified by logistic regression: adjuvant radiotherapy and capsular contracture (P = 0.034), tumor size and deflation (P = 0014), and smoking history and infection (P = 0.013). AB - Conclusions: Overall, 81% of breasts were successfully reconstructed in a single stage. Single-stage reconstruction using all-in-one expander/implants reduces costs by eliminating the need for a second procedure under general anesthesia and can achieve results comparable with other alloplastic reconstructions reported in the literature. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001609 PT - Journal Article ID - 10.1097/GOX.0000000000001609 [doi] ID - PMC5811285 [pmc] PP - epublish PH - 2017/09/19 [received] PH - 2017/10/25 [accepted] LG - English EP - 20180111 DP - 2018 Jan EZ - 2018/02/22 06:00 DA - 2018/02/22 06:01 DT - 2018/02/22 06:00 YR - 2018 RD - 20180223 UP - 20180223 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29464155 <534. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29196176 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Sheckter CC AU - Matros E AU - Momeni A FA - Sheckter, Clifford C FA - Matros, Evan FA - Momeni, Arash IN - Sheckter, Clifford C. Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA; Clinical Excellence Research Center, Stanford University School of Medicine, Stanford, CA, USA. IN - Matros, Evan. The Plastic and Reconstructive Surgery Service at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. IN - Momeni, Arash. Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: amomeni@stanford.edu. TI - Assessing value in breast reconstruction: A systematic review of cost-effectiveness studies. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 71(3):353-365, 2018 Mar AS - J Plast Reconstr Aesthet Surg. 71(3):353-365, 2018 Mar NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 71 IP - 3 PG - 353-365 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg CP - Netherlands KW - Breast reconstruction; Cost-effectiveness; Cost-utility; Plastic surgery AB - INTRODUCTION: Breast reconstruction is one of the most common procedures performed by plastic surgeons and is achieved through various choices in both technology and method. Cost-effectiveness analyses are increasingly important in assessing differences in value between treatment options, which is relevant in a world of confined resources. A thorough evaluation of the cost-effectiveness literature can assist surgeons and health systems evaluate high-value care models. AB - METHODS: A systematic review of PubMed, Web of Science, and the Cost-Effectiveness Analysis Registry was conducted. Two reviewers independently evaluated all publications up until August 17, 2017. AB - RESULTS: After removal of duplicates, 1996 records were screened, from which 53 studies underwent full text review. All the 13 studies included for final analysis mention an incremental cost-effectiveness ratio. Five studies evaluated the cost-effectiveness of technologies including acellular dermal matrix (ADM) in staged prosthetic reconstruction, ADM in direct-to-implant (DTI) reconstruction, preoperative computed tomography angiography in autologous reconstruction, indocyanine green dye angiography in evaluating anastomotic patency, and abdominal mesh reinforcement in abdominal tissue transfer. The remaining eight studies evaluated the cost-effectiveness of different reconstruction methods. Cost-effective strategies included free vs. pedicled abdominal tissue transfer, DTI vs. staged prosthetic reconstruction, and fascia-sparing variants of free abdominal tissue transfer. AB - CONCLUSIONS: Current evidence demonstrates multiple cost-effective technologies and methods in accomplishing successful breast reconstruction. Plastic surgeons should be well informed of such economic models when engaging payers and policymakers in discussions regarding high-value breast reconstruction. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30388-1 DO - https://dx.doi.org/10.1016/j.bjps.2017.09.010 PT - Journal Article ID - S1748-6815(17)30388-1 [pii] ID - 10.1016/j.bjps.2017.09.010 [doi] PP - ppublish PH - 2017/04/13 [received] PH - 2017/08/17 [revised] PH - 2017/09/12 [accepted] LG - English EP - 20171009 DP - 2018 Mar EZ - 2017/12/03 06:00 DA - 2017/12/03 06:00 DT - 2017/12/03 06:00 YR - 2018 RD - 20180215 UP - 20180216 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29196176 <535. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29434662 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Cook LJ AU - Kovacs T FA - Cook, Lorna Jane FA - Kovacs, Tibor IN - Cook, Lorna Jane. Guy's and St Thomas' NHS Trust, London SE11 4TX, UK. IN - Kovacs, Tibor. Guy's and St Thomas' NHS Trust, London SE11 4TX, UK. TI - Novel devices for implant-based breast reconstruction: is the use of meshes to support the lower pole justified in terms of benefits? A review of the evidence. [Review] SO - Ecancermedicalscience. 12:796, 2018 AS - Ecancermedicalscience. 12:796, 2018 NJ - Ecancermedicalscience VO - 12 PG - 796 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101392236 IO - Ecancermedicalscience CP - England KW - acellular dermal matrices; breast reconstruction; complications and benefits; implants AB - The use of novel devices such as acellular dermal matrices (ADMs) to support the lower pole in implant-based breast reconstructions (IBBRs) has been described as one of the most important advances in breast reconstructive surgery following mastectomy. However, the majority of outcomes studies focus primarily on providing evidence for the rates of short-term complications associated with their use, as opposed to their reported benefits. Given the high costs associated with using ADMs, together with an increasing number of alternative, cheaper synthetic products entering the market, it is important to clarify whether their use is actually justified and whether the alternative products offer equivalent or superior outcomes. The purpose of this article is to present a comprehensive and updated review of the evidence for the benefits of using different products for lower pole support (LPS) in IBBR compared to reconstructions without. A secondary aim was to determine if there is any evidence to support the use of one product over another. IS - 1754-6605 IL - 1754-6605 DO - https://dx.doi.org/10.3332/ecancer.2018.796 PT - Journal Article PT - Review ID - 10.3332/ecancer.2018.796 [doi] ID - can-12-796 [pii] ID - PMC5804716 [pmc] PP - epublish PH - 2017/03/29 [received] LG - English EP - 20180110 DP - 2018 EZ - 2018/02/13 06:00 DA - 2018/02/13 06:01 DT - 2018/02/14 06:00 YR - 2018 RD - 20180214 UP - 20180214 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29434662 <536. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29076316 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Song JH AU - Kim YS AU - Jung BK AU - Lee DW AU - Song SY AU - Roh TS AU - Lew DH FA - Song, Joon Ho FA - Kim, Young Seok FA - Jung, Bok Ki FA - Lee, Dong Won FA - Song, Seung Yong FA - Roh, Tai Suk FA - Lew, Dae Hyun IN - Song, Joon Ho. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Severance Hospital, Seoul, Korea. IN - Kim, Young Seok. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Severance Hospital, Seoul, Korea. IN - Jung, Bok Ki. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Severance Hospital, Seoul, Korea. IN - Lee, Dong Won. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. IN - Song, Seung Yong. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. IN - Roh, Tai Suk. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Severance Hospital, Seoul, Korea. IN - Lew, Dae Hyun. Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. TI - Salvage of Infected Breast Implants. SO - Archives of Plastic Surgery. 44(6):516-522, 2017 Nov AS - Arch. plast. surg.. 44(6):516-522, 2017 Nov NJ - Archives of plastic surgery VO - 44 IP - 6 PG - 516-522 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg CP - Korea (South) KW - Breast implants; Infection; Methicillin-resistant Staphylococcus aureus; Seroma AB - BACKGROUND: Implant-based breast reconstruction is being performed more frequently, and implants are associated with an increased risk of infection. We reviewed the clinical features of cases of implant infection and investigated the risk factors for breast device salvage failure. AB - METHODS: We retrospectively analyzed 771 patients who underwent implant-based breast reconstruction between January 2010 and December 2016. Age, body mass index, chemotherapy history, radiation exposure, and smoking history were assessed as potential risk factors for postoperative infection. We also evaluated the presence and onset of infection symptoms, wound culture pathogens, and other complications, including seroma, hematoma, and mastectomy skin necrosis. Additionally, we examined the mastectomy type, the use of acellular dermal matrix, the presence of an underlying disease such as hypertension or diabetes, and axillary node dissection. AB - RESULTS: The total infection rate was 4.99% (58 of 1,163 cases) and the total salvage rate was 58.6% (34 of 58). The postoperative duration to closed suction drain removal was significantly different between the cellulitis and implant removal groups. Staphylococcus aureus infection was most frequently found, with methicillin resistance in 37.5% of the cases of explantation. Explantation after infection was performed more often in patients who had undergone 2-stage expander/implant reconstruction than in those who had undergone direct-to-implant reconstruction. AB - CONCLUSIONS: Preventing infection is essential in implant-based breast reconstruction. The high salvage rate argues against early implant removal. However, when infection is due to methicillin-resistant S. aureus and the patient's clinical symptoms do not improve, surgeons should consider implant removal. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2017.01025 PT - Journal Article ID - aps.2017.01025 [pii] ID - 10.5999/aps.2017.01025 [doi] ID - PMC5801791 [pmc] PP - ppublish PH - 2017/06/13 [received] PH - 2017/10/25 [revised] PH - 2017/10/31 [accepted] LG - English EP - 20171027 DP - 2017 Nov EZ - 2017/10/28 06:00 DA - 2017/10/28 06:01 DT - 2017/10/28 06:00 YR - 2017 RD - 20180213 UP - 20180213 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29076316 <537. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29327777 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Eichler C AU - Schulz C AU - Vogt N AU - Warm M FA - Eichler, Christian FA - Schulz, Carolin FA - Vogt, Nadine FA - Warm, Mathias IN - Eichler, Christian. Breast Center, Department of Gynecology and Obstetrics, Municipal Hospital Holweide, Cologne, Germany. IN - Schulz, Carolin. Breast Center, Municipal Hospital Holweide, Cologne, Germany, Medical School MD/PhD Program, University of Bonn, Bonn, Germany. IN - Vogt, Nadine. Breast Center, Municipal Hospital Holweide, Cologne, Germany. IN - Warm, Mathias. Breast Center, Municipal Hospital Holweide, Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany. TI - The Use of Acellular Dermal Matrices (ADM) in Breast Reconstruction: A Review. SO - Surgical Technology International. 31:53-60, 2017 Dec 22 AS - Surg Technol Int. 31:53-60, 2017 Dec 22 NJ - Surgical technology international VO - 31 PG - 53-60 PI - Journal available in: Print PI - Citation processed from: Print JC - 9604509 IO - Surg Technol Int CP - United States AB - The use of acellular dermal matrices (ADM), sometimes referred to as extracellular matrix (ECM), has become an interesting aspect of breast reconstruction. A great deal of literature is available, totaling over 7000 ADM-based reconstructions. Most often, ADMs are used in a skin sparing mastectomy (SSM) scenario, although heterologous breast augmentation with a sub-pectoral fixation may also require an ADM application. Their use has become an attractive, but expensive option. Available data shows head to head comparisons between individual ADMs to be mostly retrospective in nature with only a few prospective trials available. Points of interest include postoperative hematoma, postoperative skin irritation, infection, red breast syndrome, and revision surgery. This work will, therefore, highlight the individual properties of ADMs used in breast reconstruction and compare the available data on complication rates and costs for these devices. IS - 1090-3941 IL - 1090-3941 PT - Journal Article ID - sti31/870 [pii] PP - ppublish LG - English DP - 2017 Dec 22 EZ - 2018/01/13 06:00 DA - 2018/01/13 06:00 DT - 2018/01/13 06:00 YR - 2017 RD - 20180207 UP - 20180208 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29327777 <538. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28916881 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Tsay C AU - Zhu V AU - Sturrock T AU - Shah A AU - Kwei S FA - Tsay, Cynthia FA - Zhu, Victor FA - Sturrock, Tracy FA - Shah, Ajul FA - Kwei, Stephanie IN - Tsay, Cynthia. Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, PO Box 208041, New Haven, CT, 06520-8041, USA. IN - Zhu, Victor. Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, PO Box 208041, New Haven, CT, 06520-8041, USA. IN - Sturrock, Tracy. Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, PO Box 208041, New Haven, CT, 06520-8041, USA. IN - Shah, Ajul. Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, PO Box 208041, New Haven, CT, 06520-8041, USA. IN - Kwei, Stephanie. Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, PO Box 208041, New Haven, CT, 06520-8041, USA. kweistephanie@gmail.com. TI - A 3D Mammometric Comparison of Implant-Based Breast Reconstruction With and Without Acellular Dermal Matrix (ADM). SO - Aesthetic Plastic Surgery. 42(1):49-58, 2018 Feb AS - Aesthetic Plast Surg. 42(1):49-58, 2018 Feb NJ - Aesthetic plastic surgery VO - 42 IP - 1 PG - 49-58 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - 3D imaging; Acellular dermal matrix; Aesthetics; Breast reconstruction; Mammometrics AB - This retrospective study utilizes 3D imaging and mammometrics to compare implant-based breast reconstruction with and without the use of ADM. Previous studies have suggested improved aesthetic outcomes with the use of ADM, but none have been able to quantify this difference. Images were obtained at early and late time points following the expander-implant exchange procedure. Measurements included the point of maximum projection, the superior, inferior, medial and lateral volumetric distribution, and the distance from the point of maximum projection to the inframammary fold along the breast meridian. The patients' demographic information, implant size, and complication rate between the two cohorts were similar. In the early post-operative period, the patients with ADM demonstrated higher medial pole volume; however, this difference did not persist in the late post-operative period. Patients with ADM demonstrated a small but statistically significant greater point of maximum projection and length of lower pole curvature in comparison with the non-ADM cohort. In summary, the results of this study demonstrate improved mammometric measurements when ADM is used in implant-based breast reconstruction, supporting superior aesthetic outcomes in early and late post-operative time points. AB - LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0967-z PT - Journal Article ID - 10.1007/s00266-017-0967-z [doi] ID - 10.1007/s00266-017-0967-z [pii] PP - ppublish PH - 2017/05/25 [received] PH - 2017/08/24 [accepted] LG - English EP - 20170915 DP - 2018 Feb EZ - 2017/09/17 06:00 DA - 2017/09/17 06:00 DT - 2017/09/17 06:00 YR - 2018 RD - 20180127 UP - 20180129 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28916881 <539. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28605205 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Woo KJ AU - Paik JM AU - Mun GH AU - Pyon JK AU - Jeon BJ AU - Bang SI AI - Woo, Kyong-Je; ORCID: http://orcid.org/0000-0002-7349-6743 AI - Jeon, Byung-Joon; ORCID: http://orcid.org/0000-0001-6809-9439 FA - Woo, Kyong-Je FA - Paik, Joo Myong FA - Mun, Goo-Hyun FA - Pyon, Jai-Kyong FA - Jeon, Byung-Joon FA - Bang, Sa Ik IN - Woo, Kyong-Je. a Department of Plastic Surgery , School of Medicine, Ewha Womans University , Seoul , South Korea. IN - Paik, Joo Myong. b Department of Plastic Surgery , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea. IN - Mun, Goo-Hyun. b Department of Plastic Surgery , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea. IN - Pyon, Jai-Kyong. b Department of Plastic Surgery , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea. IN - Jeon, Byung-Joon. b Department of Plastic Surgery , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea. IN - Bang, Sa Ik. b Department of Plastic Surgery , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea. TI - Analysis of factors influencing drain amount, time to drain removal, and seroma formation in patients undergoing immediate expander-implant breast reconstruction. SO - Journal of Plastic Surgery and Hand Surgery. 52(1):53-59, 2018 Feb AS - J Plast Surg Hand Surg. 52(1):53-59, 2018 Feb NJ - Journal of plastic surgery and hand surgery VO - 52 IP - 1 PG - 53-59 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101534130 IO - J Plast Surg Hand Surg CP - Sweden KW - Breast reconstruction; acellular dermal matrix; drainage; seroma; tissue expander AB - BACKGROUND: Placement of a closed suction drain is a common cause of patient complaints, such as postoperative pain or discomfort following immediate expander-implant breast reconstruction. This study aims to identify factors that affect drainage volume, time to drain removal, and seroma formation. AB - METHODS: A retrospective chart review of prospectively collected data was conducted on patients who underwent immediate expander-implant breast reconstructions following nipple-sparing or skin-sparing mastectomy without skin excision (nipple areolar complex excision only) between February 2010 and April 2015. Daily drainage volume was measured until the drain was removed. Eight independent variables, including acellular dermal matrix (ADM) usage and inflation ratio (the rate of initial inflation volume to mastectomy weight) were analysed by univariable and multivariable analyses. AB - RESULTS: A total of 162 breasts in 148 patients were included in this study. The inflation ratio did not influence the drain amount or days to drain removal. Although the use of ADM was significantly associated with increased drainage during the first 5 postoperative days (p=0.015), it was not significant when adjusted for time. Old age, larger expander size, and larger drain amount on the first postoperative day were predictors for longer days to drain removal (p<0.001). Old age had a trend toward higher risk of seroma formation that approached statistical significance (p=0.057). AB - CONCLUSIONS: The use of ADM and initial inflation ratio do not influence days to drain removal or seroma formation. A longer period of drain placement is expected when a larger expander is used or in elderly patients. ES - 2000-6764 IL - 2000-6764 DO - https://dx.doi.org/10.1080/2000656X.2017.1330208 PT - Journal Article ID - 10.1080/2000656X.2017.1330208 [doi] PP - ppublish LG - English EP - 20170612 DP - 2018 Feb EZ - 2017/06/13 06:00 DA - 2017/06/13 06:00 DT - 2017/06/13 06:00 YR - 2018 RD - 20180127 UP - 20180129 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28605205 <540. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29369979 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Mazari FAK AU - Wattoo GM AU - Kazzazi NH AU - Kolar KM AU - Olubowale OO AU - Rogers CE AU - Azmy IA FA - Mazari, Fayyaz A K FA - Wattoo, Ghulam M FA - Kazzazi, Nazar H FA - Kolar, Kadappa M FA - Olubowale, Olumuyiwa O FA - Rogers, Clare E FA - Azmy, Iman A IN - Mazari, Fayyaz A K. Nottingham, Doncaster, and Chesterfield, United Kingdom From the Nottingham Breast Institute, Nottingham University Hospitals NHS Trust, City Hospital; the Department of Breast Surgery, Doncaster & Bassetlaw Hospitals NHS Foundation Trust, Doncaster Royal Infirmary; and the Department of Breast Surgery, Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield Royal Hospital. TI - The Comparison of Strattice and SurgiMend in Acellular Dermal Matrix-Assisted, Implant-Based Immediate Breast Reconstruction. SO - Plastic & Reconstructive Surgery. 141(2):283-293, 2018 Feb AS - Plast Reconstr Surg. 141(2):283-293, 2018 Feb NJ - Plastic and reconstructive surgery VO - 141 IP - 2 PG - 283-293 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - BACKGROUND: Strattice (porcine derivative) and SurgiMend (bovine derivative) are the two most common acellular dermal matrices used in breast reconstruction in the United Kingdom. This retrospective study compared clinical outcomes in immediate implant-based breast reconstruction patients. AB - METHODS: The study, conducted across three hospitals, included all patients who underwent immediate implant-based breast reconstruction using Strattice and SurgiMend. The primary outcome measure was implant loss rate. Secondary outcome measures included acellular dermal matrix loss rate, seroma formation, and minor and major complication rates. Intergroup comparison was performed. AB - RESULTS: Eighty-two patients (Strattice, n = 45; SurgiMend, n = 37) underwent 97 immediate implant-based breast reconstructions (Strattice, n = 54; SurgiMend, n = 43). There were no differences between groups for age, comorbidities, specimen weight, or implant volume. Drains were used in all Strattice and 36 (84 percent) SurgiMend cases. The implant loss rate was higher for Strattice (n = 10, 20 percent) compared with SurgiMend (n = 3, 7 percent) but failed to reach statistical significance (chi-square test, p = 0.077). The acellular dermal matrix loss rate was significantly higher (Fisher's exact test, p = 0.014) in the Strattice group (n = 7, 14 percent), with no acellular dermal matrix loss with SurgiMend. The reoperation rate was also significantly higher (chi-square test, p = 0.002) in the Strattice group (n = 17, 33 percent, versus n = 3, 7 percent). The incidence of red breast was significantly higher (chi-square test, p = 0.022) in the SurgiMend group (n = 9, 21 percent, versus n = 3, 6 percent). Seroma, wound problems, and infection rates were similar. AB - CONCLUSIONS: Clinical outcomes, including implant loss, acellular dermal matrix loss, and reoperation rates, are significantly better when using SurgiMend in immediate implant-based breast reconstruction compared with Strattice. An appropriately powered randomized trial is needed to provide further information. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000004018 PT - Journal Article ID - 10.1097/PRS.0000000000004018 [doi] ID - 00006534-201802000-00006 [pii] PP - ppublish LG - English DP - 2018 Feb EZ - 2018/01/26 06:00 DA - 2018/01/26 06:00 DT - 2018/01/26 06:00 YR - 2018 RD - 20180125 UP - 20180126 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29369979 <541. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28455604 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Bertasi G AU - Cole W AU - Samsell B AU - Qin X AU - Moore M FA - Bertasi, Giampietro FA - Cole, Windy FA - Samsell, Brian FA - Qin, Xiaofei FA - Moore, Mark IN - Bertasi, Giampietro. University of Padua, Padua, Italy. bertasi.g@sis.it. IN - Cole, Windy. Robinson Wound Care Center, 1533 South Water Street, Kent, OH, 44240, USA. IN - Samsell, Brian. LifeNet Health, 1864 Concert Drive, Virginia Beach, VA, 23453, USA. IN - Qin, Xiaofei. LifeNet Health, 1864 Concert Drive, Virginia Beach, VA, 23453, USA. IN - Moore, Mark. LifeNet Health, 1864 Concert Drive, Virginia Beach, VA, 23453, USA. TI - Biological incorporation of human acellular dermal matrix used in Achilles tendon repair. SO - Cell & Tissue Banking. 18(3):403-411, 2017 Sep AS - Cell Tissue Bank. 18(3):403-411, 2017 Sep NJ - Cell and tissue banking VO - 18 IP - 3 PG - 403-411 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100965121 IO - Cell Tissue Bank CP - Netherlands KW - ADM; Acellular dermal matrix; Allograft; Histology; Matracell; Tendon augmentation AB - Human acellular dermal matrices (ADMs) are used successfully in a variety of procedures, including sports medicine related, wound repair, and breast reconstructions, but the mechanism of repair is still not fully understood. An opportunity to explore this mechanism presented itself when a patient experienced a rerupture of the native tendon due to a fall that occurred 2 months after undergoing an Achilles tendon repair using Matracell treated ADM. The ADM was removed and an extensive histology analysis was performed on the tissue. Additionally, a literature review was conducted to determine the mechanism of ADM integration into the tendon structure and explore if differences in this mechanism exist for different types of human ADMS. The histology analysis demonstrated that the healing process during a tendon reconstruction procedure is similar to that of wound healing. Furthermore, the literature review showed that differences exist in the mechanism for integration among various human ADMs and that these differences may be due to variances in the methods and technologies that manufactures use to process human ADMs. ES - 1573-6814 IL - 1389-9333 DO - https://dx.doi.org/10.1007/s10561-017-9628-3 PT - Journal Article ID - 10.1007/s10561-017-9628-3 [doi] ID - 10.1007/s10561-017-9628-3 [pii] ID - PMC5587623 [pmc] PP - ppublish PH - 2017/01/13 [received] PH - 2017/04/18 [accepted] LG - English EP - 20170428 DP - 2017 Sep EZ - 2017/04/30 06:00 DA - 2017/04/30 06:00 DT - 2017/04/30 06:00 YR - 2017 RD - 20171130 UP - 20171130 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28455604 <542. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28806288 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Sorkin M AU - Qi J AU - Kim HM AU - Hamill JB AU - Kozlow JH AU - Pusic AL AU - Wilkins EG FA - Sorkin, Michael FA - Qi, Ji FA - Kim, Hyungjin M FA - Hamill, Jennifer B FA - Kozlow, Jeffrey H FA - Pusic, Andrea L FA - Wilkins, Edwin G IN - Sorkin, Michael. Ann Arbor, Mich.; and New York, N.Y. From the Section of Plastic Surgery, Department of Surgery, and the Center for Statistical Consultation and Research, Department of Biostatistics, University of Michigan; and Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center. TI - Acellular Dermal Matrix in Immediate Expander/Implant Breast Reconstruction: A Multicenter Assessment of Risks and Benefits. SO - Plastic & Reconstructive Surgery. 140(6):1091-1100, 2017 Dec AS - Plast Reconstr Surg. 140(6):1091-1100, 2017 Dec NJ - Plastic and reconstructive surgery VO - 140 IP - 6 PG - 1091-1100 PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - BACKGROUND: Acellular dermal matrix has gained widespread acceptance in immediate expander/implant reconstruction because of perceived benefits, including improved expansion dynamics and superior aesthetic results. Although previous investigators have evaluated its risks, few studies have assessed the impact of acellular dermal matrix on other outcomes, including patient-reported measures. AB - METHODS: The Mastectomy Reconstruction Outcomes Consortium Study used a prospective cohort design to evaluate patients undergoing postmastectomy reconstruction from 10 centers and 58 participating surgeons between 2012 and 2015. The analysis focused on women undergoing immediate tissue expander reconstruction following mastectomies for cancer treatment or prophylaxis. Medical records and patient-reported outcome data, using the BREAST-Q and Numeric Pain Rating Scale instruments, were reviewed. Bivariate analyses and mixed-effects regression models were applied. AB - RESULTS: A total of 1297 patients were evaluated, including 655 (50.5 percent) with acellular dermal matrix and 642 (49.5 percent) without acellular dermal matrix. Controlling for demographic and clinical covariates, no significant differences were seen between acellular dermal matrix and non-acellular dermal matrix cohorts in overall complications (OR, 1.21; p = 0.263), major complications (OR, 1.43; p = 0.052), wound infections (OR, 1.49; p = 0.118), or reconstructive failures (OR, 1.55; p = 0.089) at 2 years after reconstruction. There were also no significant differences between the cohorts in the time to expander/implant exchange (p = 0.78). No significant differences were observed in patient-reported outcome scores, including satisfaction with breasts, psychosocial well-being, sexual well-being, physical well-being, and postoperative pain. AB - CONCLUSIONS: In this multicenter, prospective analysis, the authors found no significant acellular dermal matrix effects on complications, time to exchange, or patient-reported outcome in immediate expander/implant breast reconstruction. Further studies are needed to develop criteria for more selective use of acellular dermal matrix in these patients. AB - CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003842 PT - Journal Article ID - 10.1097/PRS.0000000000003842 [doi] ID - PMC5705287 [pmc] ID - NIHMS894398 [mid] PP - ppublish GI - No: R01 CA152192 Organization: (CA) *NCI NIH HHS* Country: United States LG - English DP - 2017 Dec PQ - 2018/12/01 EZ - 2017/08/15 06:00 DA - 2017/08/15 06:00 DT - 2017/08/15 06:00 YR - 2017 RD - 20171130 UP - 20171201 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28806288 <543. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28545662 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Serre A AU - Guillier D AU - Moris V AU - Rem K AU - Revol M AU - Francois C AU - Cristofari S FA - Serre, A FA - Guillier, D FA - Moris, V FA - Rem, K FA - Revol, M FA - Francois, C FA - Cristofari, S IN - Serre, A. AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: axelleserre@hotmail.fr. IN - Guillier, D. AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. IN - Moris, V. AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. IN - Rem, K. AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. IN - Revol, M. Universite Paris-Diderot, Sorbonne Paris Cite, 100-104, avenue de France, 75013 Paris, France; AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. IN - Francois, C. AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. IN - Cristofari, S. Universite Paris-Diderot, Sorbonne Paris Cite, 100-104, avenue de France, 75013 Paris, France; AP-HP, hopital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. TI - [Nipple projection augmentation in breast reconstruction by artificial derm injection]. [French] OT - Augmentation de la projection du mamelon dans les reconstructions mammaires par injection de derme artificiel. SO - Annales de Chirurgie Plastique et Esthetique. 62(6):625-629, 2017 Dec AS - Ann Chir Plast Esthet. 62(6):625-629, 2017 Dec NJ - Annales de chirurgie plastique et esthetique VO - 62 IP - 6 PG - 625-629 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 529, 8305839 IO - Ann Chir Plast Esthet CP - France KW - Artificial dermal; Breast; Derme artificiel; Hypoprojection; Injection; Mamelon; Mammaire; Nipple; Reconstruction AB - INTRODUCTION: The reconstruction of the Nipple-Areola Complex (NAC) is the last step and a key part in breast reconstruction. The technique to be used should be chosen as to avoid any complications on previous reconstruction steps. The use of local flaps for NAC reconstruction could be associated with implant exposure especially in the presence of a history of radiation therapy. The pure dermal flap could be indicated for the nipple reconstruction after breast reconstruction by implant after radiotherapy. The limit stay in the nipple hypoprojection. We suggest to assess the increase of the nipple projection, reconstructed by pure dermal flap, by injection of Integra Flowable Wound Matrix (Integra LifeSciences, Plainsboro, New jersey). AB - PATIENTS AND METHOD: Nipple projection has been measured among patients enclosed from february to March 2016 reconstructed by pure dermal flap: before, after and also at a 6months term from the injection of Integra Flowable Wound Matrix. Patient satisfaction and complications have been measured retrospectively. AB - RESULTS: Ten patients with an average of 55years have been enclosed, with an average limit of time of 19months (7 to 33months) between the breast nipple reconstruction by dermal flap and the injection. A volume of 1 to 1.6cc has been injected. A significative increase projection of 2mm at a 6months term has been measured (1.5 to 2.5mm, P<0.01), without complication and a satisfaction rate of 4.5/5. AB - CONCLUSION: The injection of an artificial derm-like Integra Flowable Wound Matrix seems to be efficient to increase the nipple projection reconstructed by pure dermal flap after a breast reconstruction and moreover, without complications. Copyright © 2017 Elsevier Masson SAS. All rights reserved. ES - 1768-319X IL - 0294-1260 DI - S0294-1260(17)30046-8 DO - https://dx.doi.org/10.1016/j.anplas.2017.03.007 PT - English Abstract PT - Journal Article ID - S0294-1260(17)30046-8 [pii] ID - 10.1016/j.anplas.2017.03.007 [doi] PP - ppublish PH - 2017/02/27 [received] PH - 2017/03/23 [accepted] LG - French EP - 20170522 DP - 2017 Dec EZ - 2017/05/27 06:00 DA - 2017/05/27 06:00 DT - 2017/05/27 06:00 YR - 2017 RD - 20171211 UP - 20171211 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28545662 <544. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28917935 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Kankam HKN AU - Hourston GJM AU - Fopp LJ AU - Benson JR AU - Benyon SL AU - Irwin MS AU - Agrawal A AU - Forouhi P AU - Malata CM FA - Kankam, Hadyn K N FA - Hourston, George J M FA - Fopp, Laura J FA - Benson, John R FA - Benyon, Sarah L FA - Irwin, Michael S FA - Agrawal, Amit FA - Forouhi, Parto FA - Malata, Charles M IN - Kankam, Hadyn K N. Cambridge University Medical School, Cambridge, UK. IN - Hourston, George J M. Cambridge University Medical School, Cambridge, UK. IN - Fopp, Laura J. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Benson, John R. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Postgraduate Medical Institute, Faculty of Health Sciences, Anglia Ruskin University, Cambridge & Chelmsford, UK. IN - Benyon, Sarah L. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Irwin, Michael S. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Agrawal, Amit. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Forouhi, Parto. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. IN - Malata, Charles M. Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Postgraduate Medical Institute, Faculty of Health Sciences, Anglia Ruskin University, Cambridge & Chelmsford, UK. Electronic address: cmalata@hotmail.com. TI - Trends in post-mastectomy breast reconstruction types at a breast cancer tertiary referral centre before and after introduction of acellular dermal matrices. SO - Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 71(1):21-27, 2018 Jan AS - J Plast Reconstr Aesthet Surg. 71(1):21-27, 2018 Jan NJ - Journal of plastic, reconstructive & aesthetic surgery : JPRAS VO - 71 IP - 1 PG - 21-27 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101264239 IO - J Plast Reconstr Aesthet Surg CP - Netherlands KW - Acellular dermal matrix; Immediate breast reconstruction; Outcomes; Trends AB - BACKGROUND: Reconstructive breast surgery has continued to evolve over the last decade with a key change being the adoption of acellular dermal matrices (ADMs) as an adjunct for implant-based procedures. This retrospective observational study assesses the effect of ADMs on post-mastectomy reconstructive practice performed in a single institution. AB - METHODS: We conducted a review of all patients undergoing breast reconstruction at a University Teaching Hospital for an 18-month period before and after adopting ADMs. Demographic, procedural and complication data for these two cohorts were compared (chi² and Student's t-tests). AB - RESULTS: A total of 264 women (336 breasts), mean age 47.5 years, were identified: 137 before and 127 after the introduction of ADM. Implant-only reconstructions increased from 16% to 52% following the adoption of ADM (p < 0.01), whereas the proportion of both latissimus dorsi and deep inferior epigastric perforator flap reconstructions decreased significantly (31%-11% and 49%-34%, respectively, p < 0.01). The rate of early complications for the implant-only procedures was not significantly different with or without ADM (26% versus 20%, respectively, p = 0.44), despite there being no difference in the rate of adjuvant radiotherapy (22% versus 35%, respectively, p = 0.30). AB - CONCLUSIONS: This study showed that since ADM introduction to our centre, more breast reconstructions have been of the implant-only type with consequent reductions in the more complex and expensive autologous techniques. Implant-only procedures that incorporated ADM use had similar complication rates to those that did not. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. ES - 1878-0539 IL - 1748-6815 DI - S1748-6815(17)30343-1 DO - https://dx.doi.org/10.1016/j.bjps.2017.08.016 PT - Journal Article ID - S1748-6815(17)30343-1 [pii] ID - 10.1016/j.bjps.2017.08.016 [doi] PP - ppublish PH - 2017/03/20 [received] PH - 2017/07/20 [revised] PH - 2017/08/14 [accepted] LG - English EP - 20170831 DP - 2018 Jan EZ - 2017/09/18 06:00 DA - 2017/09/18 06:00 DT - 2017/09/18 06:00 YR - 2018 RD - 20171218 UP - 20171218 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28917935 <545. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28820815 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Parisi D AU - Ciancio F AU - Portincasa A AU - Innocenti A FA - Parisi, Domenico FA - Ciancio, Francesco FA - Portincasa, Aurelio FA - Innocenti, Alessandro IN - Parisi, Domenico. Department of Plastic and Reconstructive Surgery, University of Foggia, Foggia, Italy Department of Plastic and Reconstructive Surgery, University of Bari, Foggia, Italy Department of Plastic and Reconstructive Surgery, University of Foggia, Foggia, Italy Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy. TI - Direct-to-Implant Breast Reconstruction without the Use of an Acellular Dermal Matrix Is Cost Effective and Oncologically Safe. CM - Comment in: Plast Reconstr Surg. 2017 Dec;140(6):821e-822e; PMID: 29176426 CM - Comment on: Plast Reconstr Surg. 2017 Apr;139(4):809-817; PMID: 28350650 SO - Plastic & Reconstructive Surgery. 140(6):820e-821e, 2017 12 AS - Plast Reconstr Surg. 140(6):820e-821e, 2017 12 NJ - Plastic and reconstructive surgery VO - 140 IP - 6 PG - 820e-821e PI - Journal available in: Print PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States ES - 1529-4242 IL - 0032-1052 DO - https://dx.doi.org/10.1097/PRS.0000000000003836 PT - Journal Article PT - Comment ID - 10.1097/PRS.0000000000003836 [doi] PP - ppublish LG - English DP - 2017 12 EZ - 2017/08/19 06:00 DA - 2017/08/19 06:00 DT - 2017/08/19 06:00 YR - 2017 RD - 20171215 UP - 20171215 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28820815 <546. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29335394 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Kolacinska A AU - Hodorowicz-Zaniewska D AU - Bocian A AU - Michalik D AU - Matkowski R AU - Kurylcio A AU - Pyka P AU - Charytonowicz M AU - Berkan M FA - Kolacinska, Agnieszka FA - Hodorowicz-Zaniewska, Diana FA - Bocian, Artur FA - Michalik, Dariusz FA - Matkowski, Rafal FA - Kurylcio, Andrzej FA - Pyka, Pawel FA - Charytonowicz, Michal FA - Berkan, Maciej IN - Kolacinska, Agnieszka. Dept of Head and Neck Cancer Surgery, Medical University of Lodz, Dept of Surgical Oncology, Cancer Center, Paderewskiego 4, 93-509 Lodz, Poland. IN - Hodorowicz-Zaniewska, Diana. I Chair of General Surgery, Dept of General, Oncological and Gastroenterological Surgery, Jagiellonian University Medical College, Cracow, Poland. IN - Bocian, Artur. Dept of Surgical Oncology, Holy Cross Cancer Center, , Poland. IN - Michalik, Dariusz. Dept of General Surgery, Ministry of the Interior and Administration Hospital, Olsztyn, Poland. IN - Matkowski, Rafal. Chair of Oncology, Dept of Surgical Oncology, Wroclaw, Poland. IN - Kurylcio, Andrzej. Dept of Surgical Oncology, Medical University, Lublin, Poland. IN - Pyka, Pawel. Dept of Surgical Oncology, District Hospital, Walbrzych, Poland. IN - Charytonowicz, Michal. Dept of Plastic Surgery, Center of Postgraduate Medical Education, Warsaw, Poland. IN - Berkan, Maciej. Dept of Oncological Gynecology with Breast Surgery Division, Copernicus Memorial Hospital, Lodz, Poland. TI - Landscape of oncoplastic breast surgery across Poland. SO - Polski Przeglad Chirurgiczny. 89(6):14-19, 2017 Dec 30 AS - Pol Przegl Chir. 89(6):14-19, 2017 Dec 30 NJ - Polski przeglad chirurgiczny VO - 89 IP - 6 PG - 14-19 PI - Journal available in: Print PI - Citation processed from: Internet JC - pb8, 0376426 IO - Pol Przegl Chir CP - Poland KW - breast cancer; oncoplastic surgery; patient reported outcomes AB - Oncoplastic and reconstructive techniques are essential tools in the armamentarium of contemporary breast surgeons. The aim of the study was to identify oncoplastic reconstructive patterns in breast cancer centers across Poland. A questionnaire of 18 questions was sent by email to the members of the Polish Society of Surgical Oncology and the Polish Society of Plastic, Reconstructive and Esthetic Surgery via their dedicated websites. The numbers of breast cancer patients operated on in each center ranged from 120 to 904 per year. Breast-conserving surgery (BCS) predominated in all but one center (range 50-70%). Immediate breast reconstructions (IBR) accounted for 6-42% of procedures, The most frequent type of IBR was either a two-stage expander followed by a permanent implant or one-stage implant- based with or without synthetic mesh. The most frequent type of delayed breast reconstruction (DBR) was a two-stage expander followed by implant-based reconstruction. None of the surveyed cancer centers performed free flap reconstruction. Deep inferior epigastric perforator (DIEP) flaps were performed in the plastic surgery department. Reconstructions based on pedicled flaps were performed in cancer centers. Acellular dermal matrices (ADM) and fat transfer were used in selected centers. In the clinical scenario of adjuvant radiotherapy, delayed breast reconstruction was favored. The full range of oncoplastic BCS was performed. Patient-reported outcome measures (PROM) and complications were assessed. Our findings can act as a platform for further improvement in skills, certification, data collection and audit, including patient reported expectation measures. There is also an urgent need to address pan-European inconsistencies in procedural reimbursement. ES - 2299-2847 IL - 0032-373X DO - https://dx.doi.org/10.5604/01.3001.0010.6735 PT - Journal Article ID - 10.5604/01.3001.0010.6735 [doi] ID - 01.3001.0010.6735 [pii] PP - ppublish LG - English DP - 2017 Dec 30 DT - 2018/01/17 06:00 YR - 2017 RD - 20180116 UP - 20180116 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29335394 <547. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29302486 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Jafferbhoy S AU - Chandarana M AU - Houlihan M AU - Parmeshwar R AU - Narayanan S AU - Soumian S AU - Harries S AU - Jones L AU - Clarke D FA - Jafferbhoy, Sadaf FA - Chandarana, Mihir FA - Houlihan, Maria FA - Parmeshwar, Rishikesh FA - Narayanan, Sankaran FA - Soumian, Soni FA - Harries, Simon FA - Jones, Lucie FA - Clarke, Dayalan IN - Jafferbhoy, Sadaf. Department of Breast Surgery, University Hospital of North Midlands, Stoke-on-Trent, UK. IN - Chandarana, Mihir. Department of Breast Surgery, University Hospital of North Midlands, Stoke-on-Trent, UK. IN - Houlihan, Maria. Department of Breast Surgery, University Hospital of North Midlands, Stoke-on-Trent, UK. IN - Parmeshwar, Rishikesh. Department of Breast Surgery, Royal Lancaster Infirmary, Lancashire, UK. IN - Narayanan, Sankaran. Department of Breast Surgery, University Hospital of North Midlands, Stoke-on-Trent, UK. IN - Soumian, Soni. Department of Breast Surgery, University Hospital of North Midlands, Stoke-on-Trent, UK. IN - Harries, Simon. Department of Breast Surgery, South Warwickshire NHS Foundation Trust, Warwick, UK. IN - Jones, Lucie. Department of Breast Surgery, South Warwickshire NHS Foundation Trust, Warwick, UK. IN - Clarke, Dayalan. Department of Breast Surgery, South Warwickshire NHS Foundation Trust, Warwick, UK. TI - Early multicentre experience of pre-pectoral implant based immediate breast reconstruction using Braxon. SO - Gland Surgery. 6(6):682-688, 2017 Dec AS - Gland surg.. 6(6):682-688, 2017 Dec NJ - Gland surgery VO - 6 IP - 6 PG - 682-688 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg CP - China (Republic : 1949- ) KW - Acellular dermal matrix (ADM); breast cancer; breast implants AB - Background: The last two decades have seen significant changes in surgical management of breast cancer. The offer of immediate breast reconstruction (IBR) following mastectomy is currently standard practice. Skin sparing and nipple sparing mastectomy with implant-based IBR have emerged as oncologically safe treatment options. Prepectoral implant placement and complete coverage of implant with acellular dermal matrix (ADM) eliminates the need to detach the muscle from underlying chest wall in contrast to the subpectoral technique. We report short-term outcomes of a multicentre study from the United Kingdom (UK) using Braxon in women having an IBR. AB - Methods: A prospective study was conducted from December 2015 to October 2016 and included all patients from three breast units in the UK who underwent a mastectomy and an implant-based IBR using Braxon. The demographic details, co-morbidities, operative details, immediate and delayed complications were recorded. Specific complications recorded were infection, seroma, unplanned readmission and loss of implant. A comparison was made with complications reported in the National Mastectomy and Reconstruction Audit. AB - Results: Seventy-eight IBRs were included in the analysis with a median follow-up of 9.98 months. Mean age of the cohort was 50 years with a mean body mass index of 25.7 kg/m². Mean implant volume was 365 cc. The inpatient hospital stay was 1.48 days. About 23% of patients had a seroma, 30% had erythema requiring antibiotics and the explant rate was 10.2 percent. Bilateral reconstructions were significantly associated with implant loss and peri-operative complications on univariate analysis. AB - Conclusions: Our early experience with this novel prepectoral technique using Braxon has shown it to be an effective technique with complication rates comparable to subpectoral IBR. The advantages of prepectoral implant-based IBR are quicker postoperative recovery and short post-operative hospital stay. Long-term studies are required to assess rippling, post-operative animation, capsular contracture and impact of radiotherapy. CI - Conflicts of Interest: The authors have no conflicts of interest to declare. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.21037/gs.2017.07.07 PT - Journal Article ID - 10.21037/gs.2017.07.07 [doi] ID - gs-06-06-682 [pii] ID - PMC5750316 [pmc] PP - ppublish LG - English DP - 2017 Dec EZ - 2018/01/06 06:00 DA - 2018/01/06 06:01 DT - 2018/01/06 06:00 YR - 2017 RD - 20180107 UP - 20180108 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29302486 <548. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29184748 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Becker H AU - Zhadan O FA - Becker, Hilton FA - Zhadan, Olga IN - Becker, Hilton. Hilton Becker Clinic of Plastic Surgery, Boca Raton, Fla.; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Fla.; Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Fla. IN - Zhadan, Olga. Hilton Becker Clinic of Plastic Surgery, Boca Raton, Fla.; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Fla.; Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, Fla. TI - Filling the Spectrum Expander with Air-A New Alternative. SO - Plastic and Reconstructive Surgery - Global Open. 5(10):e1541, 2017 Oct AS - Plast. reconstr. surg., Glob. open. 5(10):e1541, 2017 Oct NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 10 PG - e1541 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - The Spectrum adjustable saline implant is optimal for prepectoral breast reconstruction as it can be placed virtually empty and thus flat, applying no pressure on the overlying skin flap. However, when saline is added, it tends to pool at the bottom of the implant resulting in its uneven surface and rippling. Air filling results in the uniform distribution within the implant shell and smooth even implant surface, which facilitates acellular dermal matrix adhesion. Pressure to the skin flap is averted, patients are more comfortable, and rippling is not seen. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001541 PT - Journal Article ID - 10.1097/GOX.0000000000001541 [doi] ID - PMC5682184 [pmc] PP - epublish PH - 2017/06/06 [received] PH - 2017/09/01 [accepted] LG - English EP - 20171025 DP - 2017 Oct EZ - 2017/12/01 06:00 DA - 2017/12/01 06:01 DT - 2017/11/30 06:00 YR - 2017 RD - 20171219 UP - 20171220 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29184748 <549. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29098159 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Bertozzi N AU - Pesce M AU - Santi P AU - Raposio E AI - Bertozzi, Nicolo; ORCID: https://orcid.org/0000-0002-3209-3737 FA - Bertozzi, Nicolo FA - Pesce, Marianna FA - Santi, Pierluigi FA - Raposio, Edoardo IN - Bertozzi, Nicolo. Department of Medicine and Surgery, Plastic Surgery Division, University of Parma, Parma, Italy. IN - Bertozzi, Nicolo. Cutaneous, Mini-Invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy. IN - Pesce, Marianna. Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy. IN - Pesce, Marianna. Plastic Surgery Department, IRCCS San Martino University Hospital, National Institute for Cancer Research Genoa, Genoa, Italy. IN - Santi, Pierluigi. Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy. IN - Santi, Pierluigi. Plastic Surgery Department, IRCCS San Martino University Hospital, National Institute for Cancer Research Genoa, Genoa, Italy. IN - Raposio, Edoardo. Department of Medicine and Surgery, Plastic Surgery Division, University of Parma, Parma, Italy. IN - Raposio, Edoardo. Cutaneous, Mini-Invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy. TI - One-Stage Immediate Breast Reconstruction: A Concise Review. [Review] SO - BioMed Research International. 2017:6486859, 2017 AS - Biomed Res Int. 2017:6486859, 2017 NJ - BioMed research international VO - 2017 PG - 6486859 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101600173 IO - Biomed Res Int CP - United States AB - Background: One-stage direct-to-implant immediate breast reconstruction (IBR) is performed simultaneously with breast cancer resection. We explored indications, techniques, and outcomes of IBR to determine its feasibility, safety, and effectiveness. AB - Material and Methods: We reviewed the available literature on one-stage direct-to-implant IBR, with or without acellular dermal matrix (ADM), synthetic mesh, or autologous fat grafting. We analyzed the indications, preoperative work-up, surgical technique, postoperative care, outcomes, and complications. AB - Results: IBR is indicated for small-to-medium nonptotic breasts and contraindicated in patients who require or have undergone radiotherapy, due to unacceptably high complications rates. Only patients with thick, well-vascularized mastectomy flaps are IBR candidates. Expandable implants should be used for ptotic breasts, while anatomical shaped implants should be used to reconstruct small-to-medium nonptotic breasts. ADMs can be used to cover the implant during IBR and avoid muscle elevation, thereby minimizing postoperative pain. Flap necrosis, reoperation, and implant loss are more common with IBR than conventional two-staged reconstruction, but IBR has advantages such as lack of secondary surgery, faster recovery, and better quality of life. AB - Conclusions: IBR has good outcomes and patient-satisfaction rates. With ADM use, a shift from conventional reconstruction to IBR has occurred. Drawbacks of IBR can be overcome by careful patient selection. ES - 2314-6141 DO - https://dx.doi.org/10.1155/2017/6486859 PT - Journal Article PT - Review ID - 10.1155/2017/6486859 [doi] ID - PMC5643043 [pmc] PP - ppublish PH - 2017/07/21 [received] PH - 2017/08/24 [accepted] LG - English EP - 20171002 DP - 2017 EZ - 2017/11/04 06:00 DA - 2017/11/04 06:00 DT - 2017/11/04 06:00 YR - 2017 RD - 20171219 UP - 20171220 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29098159 <550. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29070989 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Vidya R AU - Cawthorn SJ FA - Vidya, Raghavan FA - Cawthorn, Simon J IN - Vidya, Raghavan. Breast Care Centre, Royal Wolverhampton Hospital NHS Trust, Wolverhampton, United Kingdom. IN - Cawthorn, Simon J. Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. TI - Muscle-Sparing ADM-Assisted Breast Reconstruction Technique Using Complete Breast Implant Coverage: A Dual-Institute UK-Based Experience. SO - Breast Care. 12(4):251-254, 2017 Sep AS - Breast Care (Basel). 12(4):251-254, 2017 Sep NJ - Breast care (Basel, Switzerland) VO - 12 IP - 4 PG - 251-254 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101254060 IO - Breast Care (Basel) CP - Switzerland KW - Acellular dermis; Breast; Breast implants; Mammaplasty; Mastectomy; Pectoralis muscles AB - BACKGROUND: We report our early experience of a novel muscle-sparing breast (prepectoral) reconstruction technique using a pre-shaped Braxon mesh (acellular dermal matrix) which completely wraps around the breast implant. AB - METHODS: All patients who underwent prepectoral implant-based breast reconstruction between April 2014 and September 2015 were included in the analysis. The dermal matrix Braxon used is a pre-shaped matrix which forms a complete implant mesh wrap. The new breast created is placed over the chest wall without disturbing the pectoralis musculature. AB - RESULTS: A total of 51 (42 unilateral and 9 bilateral) muscle-sparing breast reconstructions were carried out. Complications included implant loss (n = 1; 1.7%) secondary to wound infection, seroma (n = 4; 6.7%), and superficial wound dehiscence (n = 1; 1.7%) which was re-sutured without further complication. The median follow-up period was 16.4 (range 8-25) months. AB - CONCLUSION: The early experience appears highly satisfactory with good clinical outcome. The novel prepectoral implant-based breast reconstruction using the mesh wrap provides an effective alternative to the more traditional submuscular implant-based technique. IS - 1661-3791 IL - 1661-3791 DO - https://dx.doi.org/10.1159/000464401 PT - Journal Article ID - 10.1159/000464401 [doi] ID - brc-0012-0251 [pii] ID - PMC5649275 [pmc] PP - ppublish LG - English EP - 20170829 DP - 2017 Sep PQ - 2018/09/01 EZ - 2017/10/27 06:00 DA - 2017/10/27 06:01 DT - 2017/10/27 06:00 YR - 2017 RD - 20171219 UP - 20171220 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29070989 <551. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29062655 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Highton L AU - Johnson R AU - Kirwan C AU - Murphy J FA - Highton, Lyndsey FA - Johnson, Richard FA - Kirwan, Cliona FA - Murphy, John IN - Highton, Lyndsey. Nightingale Breast Centre, University Hospital of South Manchester NHS Foundation Trust, United Kingdom. IN - Johnson, Richard. Nightingale Breast Centre, University Hospital of South Manchester NHS Foundation Trust, United Kingdom. IN - Kirwan, Cliona. Nightingale Breast Centre, University Hospital of South Manchester NHS Foundation Trust, United Kingdom. IN - Murphy, John. Nightingale Breast Centre, University Hospital of South Manchester NHS Foundation Trust, United Kingdom. TI - Prepectoral Implant-Based Breast Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 5(9):e1488, 2017 Sep AS - Plast. reconstr. surg., Glob. open. 5(9):e1488, 2017 Sep NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 9 PG - e1488 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - BACKGROUND: The development of acellular dermal matrices (ADMs) has facilitated single-stage implant breast reconstruction (IBR) following skin-sparing mastectomy. The conventional approach of postpectoral implant placement with lower pole ADM confers a good cosmetic result by improving lower pole projection and control, while minimizing issues of implant visibility, palpability, and rippling. This is balanced with potential disadvantages including pain, disruption of pectoral muscle function, and animation. We report the results of a prospective study of prepectoral IBR with total ADM coverage. AB - METHODS: Prepectoral IBR with total ADM coverage was performed in 106 patients (166 breasts) in our institution from 2013 to 2017. The cohort included patients undergoing immediate IBR (113 breasts) and revision of existing submuscular IBR (53 breasts). Patient demographics, surgical complications, and outcomes from a prospective database were analyzed. AB - RESULTS: At a mean follow-up of 485 days, patient satisfaction and cosmetic outcomes have been good, with no significant capsular contractures or animation deformity. Minor complications including delayed healing, red breast, or seroma occurred in 14 breasts (8.4%). Major complications including necrosis and implant loss occurred in 5 breasts (3 patients), with a total explantation rate of 3%. No patients required more than an overnight stay in hospital, and there were no delays to adjuvant treatment in therapeutic cases. AB - CONCLUSION: Prepectoral implant placement with ADM cover is emerging as an alternative approach for IBR. This method facilitates breast reconstruction with a good cosmetic outcome for patients who want a quick recovery without potential compromise of pectoral muscle function and associated problems. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001488 PT - Journal Article ID - 10.1097/GOX.0000000000001488 [doi] ID - PMC5640360 [pmc] PP - epublish PH - 2017/05/05 [received] PH - 2017/07/19 [accepted] LG - English EP - 20170919 DP - 2017 Sep EZ - 2017/10/25 06:00 DA - 2017/10/25 06:01 DT - 2017/10/25 06:00 YR - 2017 RD - 20171219 UP - 20171220 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29062655 <552. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29062631 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Highton LR AU - Murphy JA FA - Highton, Lyndsey R FA - Murphy, John A IN - Highton, Lyndsey R. Nightingale Breast Centre, University Hospital of South Manchester NHS Foundation Trust, United Kingdom. IN - Murphy, John A. Nightingale Breast Centre, University Hospital of South Manchester NHS Foundation Trust, United Kingdom. TI - Immediate Nipple-Areolar Complex Reconstruction for Patients Undergoing Implant-Based Reconstruction or Therapeutic Mammoplasty. SO - Plastic and Reconstructive Surgery - Global Open. 5(9):e1243, 2017 Sep AS - Plast. reconstr. surg., Glob. open. 5(9):e1243, 2017 Sep NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 9 PG - e1243 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - BACKGROUND: We report a technique of immediate nipple-areolar complex (NAC) reconstruction for patients undergoing skin-sparing mastectomy and implant-based breast reconstruction or therapeutic mammoplasty with central excision. AB - METHODS: Immediate nipple reconstruction is performed using a modified C-V flap planned along the edge of the incision. The areola is reconstructed using a full-thickness skin graft taken from skin usually discarded during the procedure. Immediate NAC reconstruction using this technique was performed on 32 breasts in 21 patients. This included 19 risk-reducing mastectomies, 9 therapeutic mastectomies, and 2 major revisions to existing implant reconstruction. Reconstruction was direct to implant in 29 breasts and by expander in 1 breast. The device was placed in a pre- or post-pectoral plane utilizing dermal sling and/or acellular dermal matrix as determined on a case-by-case basis. Immediate NAC reconstruction was also performed on 2 patients undergoing therapeutic mammoplasty with central excision. AB - RESULTS: Mean follow-up is 12 months (5-27 months), and cosmetic results have been good. There have been no significant complications, and no revisional surgery has been required. AB - CONCLUSION: The application of simple techniques for NAC reconstruction in the primary procedure allows reconstruction of the whole breast in a single stage. There is an immediate focal point to the reconstruction to improve cosmesis, patient satisfaction, and psychosocial function without delay. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001423 PT - Journal Article ID - 10.1097/GOX.0000000000001423 [doi] ID - PMC5640328 [pmc] PP - epublish PH - 2017/01/26 [received] PH - 2017/06/02 [accepted] LG - English EP - 20170920 DP - 2017 Sep EZ - 2017/10/25 06:00 DA - 2017/10/25 06:01 DT - 2017/10/25 06:00 YR - 2017 RD - 20171219 UP - 20171220 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29062631 <553. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29037204 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Hashem T AU - Farahat A FA - Hashem, Tarek FA - Farahat, Ahmed IN - Hashem, Tarek. Department of Breast Surgery, National Cancer Institute, Cairo University, Cairo, Egypt. hashimotoo@hotmail.com. IN - Hashem, Tarek. Department of Surgical Oncology, National Cancer Institute, Nr 1.Fom el Khalig, Kasr el Aini str, Cairo, Egypt. hashimotoo@hotmail.com. IN - Farahat, Ahmed. Department of Breast Surgery, National Cancer Institute, Cairo University, Cairo, Egypt. TI - Thoracodorsal artery perforator flap as an autologous alternative to acellular dermal matrix. SO - World Journal of Surgical Oncology. 15(1):185, 2017 Oct 16 AS - World J Surg Oncol. 15(1):185, 2017 Oct 16 NJ - World journal of surgical oncology VO - 15 IP - 1 PG - 185 PI - Journal available in: Electronic PI - Citation processed from: Internet JC - 101170544 IO - World J Surg Oncol CP - England KW - Breast reconstruction; Nipple-sparing mastectomy; Perforator flaps; Subpectoral implants; Thoracodorsal artery AB - BACKGROUND: Thoracodorsal artery perforator (TDAP) flap is one of the relatively new techniques in breast reconstruction. This pedicled flap retains the benefits of perforator flaps as regards minimal donor site morbidity without the need for microvascular anastomosis. Its role in partial breast reconstruction has been well documented. However, there are few reports about the role of this flap in total breast reconstruction. AB - METHODS: This study included 47 cases who presented to the breast unit of the National Cancer Institute of Cairo University from 2013 to 2015. All patients underwent nipple-sparing mastectomy with immediate implant-based reconstruction. The TDAP flap was used to complete the subpectoral pocket for the implants in a way similar to the acellular dermal matrix. AB - RESULTS: Overall complication rate was 14.9%. Capsular contracture occurred in 6.4%.There were no donor site complications. The majority of patients were satisfied with their cosmetic results. Sixty-eight percent rated their result as "excellent" or "good." AB - CONCLUSION: Thoracodorsal artery perforator flap can play a significant role in total breast reconstruction. In settings with limited resources, this flap can serve as an available autologous alternative to acellular dermal matrix. ES - 1477-7819 IL - 1477-7819 DO - https://dx.doi.org/10.1186/s12957-017-1254-9 PT - Journal Article ID - 10.1186/s12957-017-1254-9 [doi] ID - 10.1186/s12957-017-1254-9 [pii] ID - PMC5644174 [pmc] PP - epublish PH - 2017/04/03 [received] PH - 2017/10/09 [accepted] LG - English EP - 20171016 DP - 2017 Oct 16 EZ - 2017/10/19 06:00 DA - 2017/10/19 06:00 DT - 2017/10/18 06:00 YR - 2017 RD - 20171219 UP - 20171220 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29037204 <554. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29080661 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Pompei S AU - Evangelidou D AU - Arelli F AU - Ferrante G FA - Pompei, Stefano FA - Evangelidou, Dora FA - Arelli, Floriana FA - Ferrante, Gianluigi IN - Pompei, Stefano. Plastic and Reconstructive Surgery Unit, San Camillo General Hospital, Circonvallazione Gianicolense, 87, Rome 00152, Italy. IN - Evangelidou, Dora. Plastic and Reconstructive Surgery Department, CosmeSurge and Emirates Hospital, Jumeirah Beach Road, P.O. Box 71860, Dubai, United Arab Emirates. Electronic address: dr.evangelidou@gmail.com. IN - Arelli, Floriana. Plastic and Reconstructive Surgery Unit, San Camillo General Hospital, Circonvallazione Gianicolense, 87, Rome 00152, Italy. IN - Ferrante, Gianluigi. National Center of Disease Prevention and Health Promotion, Italian National Institute of Health, Viale Regina Elena, Rome 299 00161, Italy. TI - The Use of TIGR Matrix in Breast Aesthetic and Reconstructive Surgery: Is a Resorbable Synthetic Mesh a Viable Alternative to Acellular Dermal Matrices?. [Review] SO - Clinics in Plastic Surgery. 45(1):65-73, 2018 Jan AS - Clin Plast Surg. 45(1):65-73, 2018 Jan NJ - Clinics in plastic surgery VO - 45 IP - 1 PG - 65-73 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg CP - United States KW - ADM alternative; Mesh in aesthetic breast; Reconstruction with mesh; Resorbable mesh; Synthetic mesh; TIGR matrix AB - The authors document their experience in the use of synthetic 100% bioresorbable surgical mesh (TIGR Matrix, Novus Scientific, Uppsala, Sweden) in breast reconstruction as well as in breast aesthetic surgery. They performed a retrospective review on patients who underwent implant-based breast reconstruction as well as patients who underwent breast reduction mammoplasty procedures with the use of TIGR Matrix Surgical Mesh. When compared with other synthetic but nonresorbable meshes, it appears to show a potentially lower seroma and infection rates, but most importantly, a lower rate of revisional and mesh explantation surgeries. Copyright © 2017 Elsevier Inc. All rights reserved. ES - 1558-0504 IL - 0094-1298 DI - S0094-1298(17)30132-3 DO - https://dx.doi.org/10.1016/j.cps.2017.08.005 PT - Journal Article PT - Review ID - S0094-1298(17)30132-3 [pii] ID - 10.1016/j.cps.2017.08.005 [doi] PP - ppublish LG - English EP - 20170918 DP - 2018 Jan EZ - 2017/10/31 06:00 DA - 2017/10/31 06:00 DT - 2017/10/30 06:00 YR - 2018 RD - 20171029 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29080661 <555. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29080660 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Zenn MR FA - Zenn, Michael R IN - Zenn, Michael R. 2001 Weston Parkway, Cary, NC 27513, USA. Electronic address: drzenn@careplasticsurgery.com. TI - Indications and Controversies for Implant-Based Breast Reconstruction Utilizing Biological Meshes. [Review] SO - Clinics in Plastic Surgery. 45(1):55-63, 2018 Jan AS - Clin Plast Surg. 45(1):55-63, 2018 Jan NJ - Clinics in plastic surgery VO - 45 IP - 1 PG - 55-63 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - dhx, 0424767 IO - Clin Plast Surg CP - United States KW - ADM; DTI; Direct-to-implant nipple-sparing implant breast reconstruction; NSM; SSM AB - The advent of acellular dermal matrices (ADMs) has changed the way implant reconstruction is performed and has opened the door to muscle-sparing techniques that can be performed as an NSM (nipple-sparing mastectomy) with DTI (direct to implant) with excellent cosmesis and less patient morbidity. The article discusses differences in types of ADMs and outlines some current strategies and controversies with ADM use. Copyright © 2017 Elsevier Inc. All rights reserved. ES - 1558-0504 IL - 0094-1298 DI - S0094-1298(17)30131-1 DO - https://dx.doi.org/10.1016/j.cps.2017.08.004 PT - Journal Article PT - Review ID - S0094-1298(17)30131-1 [pii] ID - 10.1016/j.cps.2017.08.004 [doi] PP - ppublish LG - English EP - 20170914 DP - 2018 Jan EZ - 2017/10/31 06:00 DA - 2017/10/31 06:00 DT - 2017/10/30 06:00 YR - 2018 RD - 20171029 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=29080660 <556. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28916851 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Bailey CM AU - Pu LLQ FA - Bailey, Chad M FA - Pu, Lee L Q IN - Bailey, Chad M. Division of Plastic Surgery, Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA. IN - Pu, Lee L Q. Division of Plastic Surgery, Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA. llpu@ucdavis.edu. IN - Pu, Lee L Q. Division of Plastic Surgery, University of California at Davis, 2221 Stockton Blvd, Suite 2123, Sacramento, CA, 95817, USA. llpu@ucdavis.edu. TI - Commentary: Application of Human Acellular Breast Dermal Matrix (ABDM) in Implant-Based Breast Reconstruction: An Experimental Study. SO - Aesthetic Plastic Surgery. 41(6):1445-1446, 2017 Dec AS - Aesthetic Plast Surg. 41(6):1445-1446, 2017 Dec NJ - Aesthetic plastic surgery VO - 41 IP - 6 PG - 1445-1446 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0968-y PT - Journal Article ID - 10.1007/s00266-017-0968-y [doi] ID - 10.1007/s00266-017-0968-y [pii] PP - ppublish PH - 2017/08/15 [received] PH - 2017/08/25 [accepted] LG - English EP - 20170915 DP - 2017 Dec EZ - 2017/09/17 06:00 DA - 2017/09/17 06:00 DT - 2017/09/17 06:00 YR - 2017 RD - 20171122 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28916851 <557. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28831365 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Bettinger LN AU - Waters LM AU - Reese SW AU - Kutner SE AU - Jacobs DI FA - Bettinger, Lynne N FA - Waters, Linda M FA - Reese, Stephen W FA - Kutner, Susan E FA - Jacobs, Daniel I IN - Bettinger, Lynne N. Boston University Medical School, Boston, Mass.; Department of Surgery, Stanford University Medical Center, Stanford University School Stanford University Medical Center, Stanford School of Medicine, Stanford, Calif.; Department of Surgery Kaiser Permanente Medical Center San Jose, San Jose, Calif.; Adjunct Clinical Faculty, Division of Plastic Surgery, Department of Surgery, Stanford University, Stanford, Calif.; Columbia University, School of Professional Studies, Graduate Studies in Bioethics, New York, N.Y.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. IN - Waters, Linda M. Boston University Medical School, Boston, Mass.; Department of Surgery, Stanford University Medical Center, Stanford University School Stanford University Medical Center, Stanford School of Medicine, Stanford, Calif.; Department of Surgery Kaiser Permanente Medical Center San Jose, San Jose, Calif.; Adjunct Clinical Faculty, Division of Plastic Surgery, Department of Surgery, Stanford University, Stanford, Calif.; Columbia University, School of Professional Studies, Graduate Studies in Bioethics, New York, N.Y.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. IN - Reese, Stephen W. Boston University Medical School, Boston, Mass.; Department of Surgery, Stanford University Medical Center, Stanford University School Stanford University Medical Center, Stanford School of Medicine, Stanford, Calif.; Department of Surgery Kaiser Permanente Medical Center San Jose, San Jose, Calif.; Adjunct Clinical Faculty, Division of Plastic Surgery, Department of Surgery, Stanford University, Stanford, Calif.; Columbia University, School of Professional Studies, Graduate Studies in Bioethics, New York, N.Y.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. IN - Kutner, Susan E. Boston University Medical School, Boston, Mass.; Department of Surgery, Stanford University Medical Center, Stanford University School Stanford University Medical Center, Stanford School of Medicine, Stanford, Calif.; Department of Surgery Kaiser Permanente Medical Center San Jose, San Jose, Calif.; Adjunct Clinical Faculty, Division of Plastic Surgery, Department of Surgery, Stanford University, Stanford, Calif.; Columbia University, School of Professional Studies, Graduate Studies in Bioethics, New York, N.Y.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. IN - Jacobs, Daniel I. Boston University Medical School, Boston, Mass.; Department of Surgery, Stanford University Medical Center, Stanford University School Stanford University Medical Center, Stanford School of Medicine, Stanford, Calif.; Department of Surgery Kaiser Permanente Medical Center San Jose, San Jose, Calif.; Adjunct Clinical Faculty, Division of Plastic Surgery, Department of Surgery, Stanford University, Stanford, Calif.; Columbia University, School of Professional Studies, Graduate Studies in Bioethics, New York, N.Y.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. TI - Comparative Study of Prepectoral and Subpectoral Expander-Based Breast Reconstruction and Clavien IIIb Score Outcomes. SO - Plastic and Reconstructive Surgery - Global Open. 5(7):e1433, 2017 Jul AS - Plast. reconstr. surg., Glob. open. 5(7):e1433, 2017 Jul NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 7 PG - e1433 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Prepectoral breast reconstruction is increasingly popular. This study compares complications between 2 subpectoral and 1 prepectoral breast reconstruction technique. AB - METHODS: Between 2008 and 2015, 294 two-staged expander breast reconstructions in 213 patients were performed with 1 of 3 surgical techniques: (1) Prepectoral, (2) subpectoral with acellular dermal matrix (ADM) sling ("Classic"), or (3) subpectoral/subserratus expander placement without ADM ("No ADM"). Demographics, comorbidities, radiation therapy, and chemotherapy were assessed for correlation with Clavien IIIb score outcomes. Follow-up was a minimum of 6 months. AB - RESULTS: Surgical cohorts (n = 165 Prepectoral; n = 77 Classic; n = 52 No ADM) had comparable demographics except Classic had more cardiac disease (P = 0.03), No ADM had higher body mass index (BMI) (P = 0.01), and the Prepectoral group had more nipple-sparing mastectomies (P < 0.001). Univariate analysis showed higher expander complications with BMI >= 40 (P = 0.05), stage 4 breast cancer (P = 0.01), and contralateral prophylactic mastectomy (P = 0.1), whereas implant complications were associated with prior history of radiation (P < 0.01). There was more skin necrosis (P = 0.05) and overall expander complications (P = 0.01) in the Classic cohort, whereas the No ADM group trended toward the lowest expander complications among the 3. Multivariate analysis showed no difference in overall expander complication rates between the 3 groups matching demographics, mastectomy surgery, risks, and surgical technique. AB - CONCLUSIONS: Prepectoral and subpectoral Classic and No ADM breast reconstructions demonstrated comparable grade IIIb Clavien score complications. BMI > 40, stage 4 cancer, and contralateral prophylactic mastectomy were associated with adverse expander outcomes and a prior history of radiation therapy adversely impacted implant outcomes. Ninety-day follow-up for expander and implant complications may be a better National Surgical Quality Improvement Program measure. CI - Disclosure: None of the authors has a financial interest in any of the products or devices mentioned in this article. Dr. Daniel Jacobs is a co-founder for AirXpanders, Inc., not involved in this study. The Article Processing Charge was paid for by the authors. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001433 PT - Journal Article ID - 10.1097/GOX.0000000000001433 [doi] ID - PMC5548588 [pmc] PP - epublish PH - 2017/01/26 [received] PH - 2017/06/09 [accepted] LG - English EP - 20170726 DP - 2017 Jul EZ - 2017/08/24 06:00 DA - 2017/08/24 06:01 DT - 2017/08/24 06:00 YR - 2017 RD - 20170827 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28831365 <558. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28831349 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Brichacek M AU - Dalke K AU - Buchel E AU - Hayakawa TEJ FA - Brichacek, Michal FA - Dalke, Kimberly FA - Buchel, Edward FA - Hayakawa, Thomas E J IN - Brichacek, Michal. Section of Plastic Surgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada. IN - Dalke, Kimberly. Section of Plastic Surgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada. IN - Buchel, Edward. Section of Plastic Surgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada. IN - Hayakawa, Thomas E J. Section of Plastic Surgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada. TI - A Limited Submuscular Direct-to-Implant Technique Utilizing AlloMax. SO - Plastic and Reconstructive Surgery - Global Open. 5(7):e1408, 2017 Jul AS - Plast. reconstr. surg., Glob. open. 5(7):e1408, 2017 Jul NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 7 PG - e1408 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - This study evaluates a novel limited submuscular direct-to-implant technique utilizing AlloMax where only the upper few centimeters of the implant is covered by the pectoralis, whereas the majority of the implant including the middle and lower poles are covered by acellular dermal matrix. AB - METHODS: The pectoralis muscle is released off its inferior and inferior-medial origins and allowed to retract superiorly. Two sheets of AlloMax (6x16cm) are sutured together and secured to the inframammary fold, serratus fascia, and the superiorly retracted pectoralis. Thirty-seven breasts in 19 consecutive patients with follow-up at 6 months were reviewed. AB - RESULTS: Nineteen consecutive patients with 37 reconstructed breasts were studied. Average age was 50 years, average BMI was 24.3. Ptosis ranged from grade 0-III, and average cup size was B (range, A-DDD). Early minor complications included 1 seroma, 3 minor postoperative hematomas managed conservatively, and 3 minor wound healing problems. Three breasts experienced mastectomy skin flap necrosis and were managed with local excision. There were no cases of postoperative infection, red breast, grade III/IV capsular contractures, or implant loss. A single patient complained of animation postoperatively. One patient desired fat grafting for rippling. AB - CONCLUSIONS: The limited submuscular direct-to-implant technique utilizing AlloMax appears to be safe with a low complication rate at 6 months. This technique minimizes the action of the pectoralis on the implant, reducing animation deformities but still providing muscle coverage of the upper limit of the implant. Visible rippling is reduced, and a vascularized bed remains for fat grafting of the upper pole if required. CI - Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the authors. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001408 PT - Journal Article ID - 10.1097/GOX.0000000000001408 [doi] ID - PMC5548572 [pmc] PP - epublish PH - 2017/05/05 [received] PH - 2017/05/19 [accepted] LG - English EP - 20170705 DP - 2017 Jul EZ - 2017/08/24 06:00 DA - 2017/08/24 06:01 DT - 2017/08/24 06:00 YR - 2017 RD - 20170827 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28831349 <559. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28831348 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Nigro LC AU - Blanchet NP FA - Nigro, Lauren C FA - Blanchet, Nadia P IN - Nigro, Lauren C. Division of Plastic and Reconstructive Surgery, De partment of Surgery, Virginia Commonwealth University, Richmond, Va. IN - Blanchet, Nadia P. Division of Plastic and Reconstructive Surgery, De partment of Surgery, Virginia Commonwealth University, Richmond, Va. TI - Animation Deformity in Postmastectomy Implant-Based Reconstruction. SO - Plastic and Reconstructive Surgery - Global Open. 5(7):e1407, 2017 Jul AS - Plast. reconstr. surg., Glob. open. 5(7):e1407, 2017 Jul NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 7 PG - e1407 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Despite increasing interest in prepectoral implant-based reconstruction to avoid animation deformity (AD), the prevalence of this deformity and patient attitudes toward it have not been extensively studied. The purpose of this study was to report on AD in the breast reconstruction population and identify those at highest risk. AB - METHODS: A retrospective chart review was completed for patients at least 6 months postoperative from subpectoral, implant-based breast reconstruction using acellular dermal matrix in the lower pole. Patient age, BMI, and implant size were collected. A questionnaire was distributed to the patients. Returned questionnaires were compiled and data were analyzed. AB - RESULTS: Eighty-four of 108 patients (77.8%) returned the questionnaire with 62 (75.6%) reporting AD; 75.6% of patients were aware of AD, 14.6% considered it moderate, and 11% considered it severe. No statistically significant differences in age, body mass index, implant size, or athleticism were found between those who noted AD versus those who did not. Forty-one of 79 patients (51.9%) would have been interested in an initial surgical procedure without AD; interest dropped significantly if the alternative surgery involved increased risk, cost, or additional stages of reconstruction. AB - CONCLUSION: The prevalence of AD in subpectoral implant-based breast reconstruction is significantly higher than in subpectoral augmentation. The majority of patients expressed interest in an alternative procedure to avoid AD unless it involved increased risk, cost, or additional surgeries. We found insignificant differences in age, athleticism, BMI, and implant size between patients who note AD and those who do not. Further study is necessary to better define patients at risk for AD to guide patient-centered breast reconstruction. CI - Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the authors. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001407 PT - Journal Article ID - 10.1097/GOX.0000000000001407 [doi] ID - PMC5548571 [pmc] PP - epublish PH - 2017/05/10 [received] PH - 2017/05/19 [accepted] LG - English EP - 20170724 DP - 2017 Jul EZ - 2017/08/24 06:00 DA - 2017/08/24 06:01 DT - 2017/08/24 06:00 YR - 2017 RD - 20170827 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28831348 <560. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28831335 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Singla A AU - Singla A AU - Lai E AU - Caminer D FA - Singla, Apresh FA - Singla, Animesh FA - Lai, Eric FA - Caminer, David IN - Singla, Apresh. Department of Plastic Surgery, St Vincent's Hospital, Sydney, NSW, Australia; and University of New South Wales, Sydney, NSW, Australia. IN - Singla, Animesh. Department of Plastic Surgery, St Vincent's Hospital, Sydney, NSW, Australia; and University of New South Wales, Sydney, NSW, Australia. IN - Lai, Eric. Department of Plastic Surgery, St Vincent's Hospital, Sydney, NSW, Australia; and University of New South Wales, Sydney, NSW, Australia. IN - Caminer, David. Department of Plastic Surgery, St Vincent's Hospital, Sydney, NSW, Australia; and University of New South Wales, Sydney, NSW, Australia. TI - Subcutaneously Placed Breast Implants after a Skin-Sparing Mastectomy: Do We Always Need ADM?. SO - Plastic and Reconstructive Surgery - Global Open. 5(7):e1371, 2017 Jul AS - Plast. reconstr. surg., Glob. open. 5(7):e1371, 2017 Jul NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 7 PG - e1371 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Immediate breast reconstruction is an acceptable treatment option after mastectomy for prophylaxis of early breast cancer. Different options exist for implant placement, incision technique, patient suitability, and institutional experience. This article is a case series exploring the feasibility and outcomes of patients undergoing immediate breast reconstruction using skin-sparing mastectomy without mesh or acellular dermal matrix (ADM) and with a vertical inframammary incision. AB - METHODS: A single-institution retrospective analysis was performed for all patients who underwent immediate single-stage reconstruction with subcutaneous silicon implants without ADM between 2009 and 2014 inclusive. Patient, operative and treatment variables were extracted. All patients with viable mastectomy skin flaps intraoperatively and at least 5mm of subcutaneous tissue were eligible except for patients who were deemed too slim by the senior surgeon preoperatively and thus at risk of implant visibility or skin rippling. AB - RESULTS: There were 26 patients (bilateral n = 12 and unilateral n = 14) eligible for analysis, with a median long-term follow-up of 51.5 months. The majority of complications were classified as minor affecting 46.2% of the cohort (n = 12). There were 20 episodes of complications overall. The most frequent episodes were contour defects (x = 5), minor seroma (x = 4), and malrotation and minor infection (x = 3). There was 1 episode of capsular contracture. AB - CONCLUSION: Skin-sparing mastectomy with immediate subcutaneous silicon implant reconstruction with a vertical incision and without the need for mesh or ADM is an acceptable and safe treatment option. Accurate patient selection and skin flap viability is the key to achieving optimal outcomes with this approach. CI - Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the authors. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001371 PT - Journal Article ID - 10.1097/GOX.0000000000001371 [doi] ID - PMC5548558 [pmc] PP - epublish PH - 2016/11/20 [received] PH - 2017/04/20 [accepted] LG - English EP - 20170712 DP - 2017 Jul EZ - 2017/08/24 06:00 DA - 2017/08/24 06:01 DT - 2017/08/24 06:00 YR - 2017 RD - 20170827 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28831335 <561. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28765784 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Bertozzi N AU - Pesce M AU - Santi P AU - Raposio E FA - Bertozzi, Nicolo FA - Pesce, Marianna FA - Santi, PierLuigi FA - Raposio, Edoardo IN - Bertozzi, Nicolo. Department of Medicine and Surgery, Plastic Surgery Division, University of Parma, Cutaneous, Mini-invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy. IN - Bertozzi, Nicolo. Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Plastic Surgery Department, IRCCS San Martino University Hospital, National Institute for Cancer Research, Genoa, Italy. IN - Pesce, Marianna. Department of Plastic and Reconstructive Surgery, San Martino-IST University of Genova, Genova, Italy. IN - Santi, PierLuigi. Department of Plastic and Reconstructive Surgery, San Martino-IST University of Genova, Genova, Italy. IN - Raposio, Edoardo. Department of Medicine and Surgery, Plastic Surgery Division, University of Parma, Cutaneous, Mini-invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy. IN - Raposio, Edoardo. Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Plastic Surgery Department, IRCCS San Martino University Hospital, National Institute for Cancer Research, Genoa, Italy. TI - Tissue expansion for breast reconstruction: Methods and techniques. [Review] SO - Annals of Medicine & Surgery. 21:34-44, 2017 Sep AS - Ann Med Surg (Lond). 21:34-44, 2017 Sep NJ - Annals of medicine and surgery (2012) VO - 21 PG - 34-44 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101616869 IO - Ann Med Surg (Lond) CP - England KW - Breast cancer; Breast implants; Breast surgery; Reconstructive surgery; Tissue expansion AB - OBJECTIVE: In this work, the authors review recent data on the different methods and techniques of TE/implant-based reconstruction to determine the complication profiles and the advantages and disadvantages of the different techniques. This information will be valuable for surgeons performing breast reconstructions. AB - MATERIALS AND METHODS: A thorough literature review was conducted by the authors concerning the current strategy of tissue expander (TE)/implant-based breast reconstruction following breast cancer surgery. AB - RESULTS: Loss of the breast can strongly affect a woman's personal and social life while breast reconstruction reduces the sense of mutilation felt by women after a mastectomy, and provides psychosocial as well as aesthetic benefits. TE/implant-based reconstruction is the most common breast reconstructive strategy, constituting almost 65% of all breast reconstructions in the US. Although numerous studies have been published on various aspects of alloplastic breast reconstructions, most studies are single-center observations. No evidence-based guidelines are available as yet. Conventional TE/implant-based reconstruction can be performed as a two-stage procedure either in the immediate or delayed setting. Moreover, the adjunctive use of acellular dermal matrix further broadened the alloplastic breast reconstruction indication and also enhanced aesthetic outcomes. AB - CONCLUSIONS: TE/implant-based reconstruction has proved to be a safe, cost-effective, and reliable technique that can be performed in women with various comorbidities. Short operative time, fast recovery, and absence of donor site morbidity are other advantages over autologous breast reconstruction. IS - 2049-0801 IL - 2049-0801 DO - https://dx.doi.org/10.1016/j.amsu.2017.07.048 PT - Journal Article PT - Review ID - 10.1016/j.amsu.2017.07.048 [doi] ID - S2049-0801(17)30289-3 [pii] ID - PMC5526469 [pmc] PP - epublish PH - 2017/04/27 [received] PH - 2017/07/18 [revised] PH - 2017/07/18 [accepted] LG - English EP - 20170721 DP - 2017 Sep EZ - 2017/08/03 06:00 DA - 2017/08/03 06:01 DT - 2017/08/03 06:00 YR - 2017 RD - 20170824 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28765784 <562. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28740788 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Hon HH AU - Mubang RN AU - Wernick BD AU - Freedman SF AU - Stoltzfus JC AU - Miele LF AU - Stawicki SP AU - Morrissey WM Jr FA - Hon, Heidi H FA - Mubang, Ronnie N FA - Wernick, Brian D FA - Freedman, Samuel F FA - Stoltzfus, Jill C FA - Miele, Lino F FA - Stawicki, Stanislaw P FA - Morrissey, W Michael Jr IN - Hon, Heidi H. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Mubang, Ronnie N. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Wernick, Brian D. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Freedman, Samuel F. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Stoltzfus, Jill C. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Miele, Lino F. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Stawicki, Stanislaw P. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. IN - Morrissey, W Michael Jr. Department of Surgery, Section of Plastic Surgery, The Research Institute, St. Luke's University Health Network, Bethlehem, Pa.; and Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pa. TI - Acellular Dermal Matrix Versus Inferior Deepithelialized Flap Breast Reconstruction: Equivalent Outcomes, with Increased Cost. SO - Plastic and Reconstructive Surgery - Global Open. 5(6):e1382, 2017 Jun AS - Plast. reconstr. surg., Glob. open. 5(6):e1382, 2017 Jun NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 6 PG - e1382 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - BACKGROUND: Approximately 250,000 new cases of breast cancer are diagnosed yearly in the U.S. resulting in more postmastectomy breast reconstructions (PMBRs). The acellular dermal matrix (ADM) expander-implant method became popular in the mid-2000s, but newer techniques such as the inferior deepithelialized flap (IDF) has more recently been described. We hypothesize that ADMs and IDFs provide comparable aesthetic outcomes, with no difference in complication rates and operative characteristics. AB - METHODS: A retrospective, single-institution study was performed between July 1, 2012, and June 30, 2014, examining all PMBR's (ADM and IDF). Outcomes were categorized as clinical (e.g., complications requiring surgical intervention) or aesthetic. AB - RESULTS: A total of 65 patients (41 ADM; 24 IDF; mean age, 53.4+/-10.7 years) were included, with 101 PMBR's evaluated (63 ADM and 38 IDF). Patients who underwent IDFs had higher body mass index (32 versus 25; P < 0.01) and higher grades of breast ptosis. Major complication rates were similar between ADM and IDF groups (22% versus 31.5%; P = 0.34). There were no differences in aesthetic outcomes between groups (rater intraclass correlation, 0.92). The average IDF breast reconstruction took nearly 30 minutes longer per reconstructed side (192 minutes versus 166 minutes; P = 0.02), but operative costs were more expensive for the ADM breast reconstruction. AB - CONCLUSIONS: The IDF procedure took 30 minutes longer for each reconstructed side, without significant differences in complications or aesthetic outcomes between the 2 PMBRs. IDF reconstructions may be more suitable for patients with grade 3 breast ptosis and higher body mass index. Further studies should focus on long-term outcomes and value-based approaches to PMBR. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001382 PT - Journal Article ID - 10.1097/GOX.0000000000001382 [doi] ID - PMC5505849 [pmc] PP - epublish PH - 2016/11/16 [received] PH - 2017/04/25 [accepted] LG - English EP - 20170628 DP - 2017 Jun EZ - 2017/07/26 06:00 DA - 2017/07/26 06:01 DT - 2017/07/26 06:00 YR - 2017 RD - 20170728 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28740788 <563. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28740777 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Vidya R FA - Vidya, Raghavan IN - Vidya, Raghavan. Department of Breast Surgery, Royal Wolverhampton Hospital, Wolverhampton, United Kingdom. TI - Prepectoral Breast Reconstruction or Muscle-Sparing Technique with the Braxon Porcine Acellular Dermal Matrix. SO - Plastic and Reconstructive Surgery - Global Open. 5(6):e1364, 2017 Jun AS - Plast. reconstr. surg., Glob. open. 5(6):e1364, 2017 Jun NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 6 PG - e1364 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - Supplemental Digital Content is available in the text. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001364 PT - Journal Article ID - 10.1097/GOX.0000000000001364 [doi] ID - PMC5505838 [pmc] PP - epublish PH - 2016/12/22 [received] PH - 2017/04/20 [accepted] LG - English EP - 20170619 DP - 2017 Jun EZ - 2017/07/26 06:00 DA - 2017/07/26 06:01 DT - 2017/07/26 06:00 YR - 2017 RD - 20170728 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28740777 <564. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28710505 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Nafisi N AU - Akbari ME AU - Mahjoub F AU - Mohseni MJ AU - Sabetkish S AU - Khorramirouz R AU - Tehrani M AU - Kajbafzadeh AM FA - Nafisi, Nahid FA - Akbari, Mohammad Esmaeil FA - Mahjoub, Fatemeh FA - Mohseni, Mohammad Javad FA - Sabetkish, Shabnam FA - Khorramirouz, Reza FA - Tehrani, Mona FA - Kajbafzadeh, Abdol-Mohammad IN - Nafisi, Nahid. Iran University of Medical Science, RasoleAkram Hospital, Tehran, Islamic Republic of Iran. IN - Akbari, Mohammad Esmaeil. Iran University of Medical Science, RasoleAkram Hospital, Tehran, Islamic Republic of Iran. IN - Akbari, Mohammad Esmaeil. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. IN - Mahjoub, Fatemeh. Department of Pathology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. IN - Mohseni, Mohammad Javad. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Qarib's Street, Keshavarz Boulevard, Tehran, 1419433151, Islamic Republic of Iran. IN - Sabetkish, Shabnam. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Qarib's Street, Keshavarz Boulevard, Tehran, 1419433151, Islamic Republic of Iran. IN - Khorramirouz, Reza. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Qarib's Street, Keshavarz Boulevard, Tehran, 1419433151, Islamic Republic of Iran. IN - Tehrani, Mona. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Qarib's Street, Keshavarz Boulevard, Tehran, 1419433151, Islamic Republic of Iran. IN - Kajbafzadeh, Abdol-Mohammad. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Qarib's Street, Keshavarz Boulevard, Tehran, 1419433151, Islamic Republic of Iran. kajbafzd@sina.tums.ac.ir. TI - Application of Human Acellular Breast Dermal Matrix (ABDM) in Implant-Based Breast Reconstruction: An Experimental Study. SO - Aesthetic Plastic Surgery. 41(6):1435-1444, 2017 Dec AS - Aesthetic Plast Surg. 41(6):1435-1444, 2017 Dec NJ - Aesthetic plastic surgery VO - 41 IP - 6 PG - 1435-1444 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Acellularization; Breast; Dermal matrix; Reconstruction AB - BACKGROUND: The use of acellular dermal matrices (ABDM) has become more common for breast reconstruction to improve postoperative outcomes. We evaluated the efficacy of breast reconstruction by the application of human ABDM in a sheep model. AB - METHODS: The sheep in group I (GI) (N = 4) underwent the following procedures on the right side: (1) breast reconstruction using human ABDM after total mastectomy, (2) human ABDM under the skin, near the breast area and on the left side, (3) fat injection and human ABDM after partial mastectomy, and (4) replacement of ABDM in the abdominal wall far from the breast. Sheep in group II (GII) (N = 4) underwent the following procedures. On the right side: (1) breast reconstruction using ABDM after total mastectomy, (2) replacement of ABDM under the skin, near the breast area, and on the left side, (3) application of vicryl synthetic mesh after partial mastectomy and (4) replacement of mesh under the skin, near the breast area. AB - RESULTS: Histological evaluations of decellularized skin scaffolds demonstrated a collagen-based matrix with preserved ECM and complete nuclear removal. Histological evaluations of implanted ABDM demonstrated a viable matrix with fibroblast infiltration and revascularization in all follow-ups. The overall surgical complication rate was significantly lower in the ABDM implant under the skin and near the breast in both short- and long-term follow-ups. AB - CONCLUSION: The results of this study demonstrated that the application of novel prepared ABDMs has promising outcomes for breast reconstruction to provide total coverage without the need for breast expansion before implant placement. AB - NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266. ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0931-y PT - Journal Article ID - 10.1007/s00266-017-0931-y [doi] ID - 10.1007/s00266-017-0931-y [pii] PP - ppublish PH - 2017/01/29 [received] PH - 2017/06/21 [accepted] LG - English EP - 20170714 DP - 2017 Dec EZ - 2017/07/16 06:00 DA - 2017/07/16 06:00 DT - 2017/07/16 06:00 YR - 2017 RD - 20171122 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28710505 <565. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28695010 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Paprottka FJ AU - Krezdorn N AU - Sorg H AU - Konneker S AU - Bontikous S AU - Robertson I AU - Schlett CL AU - Dohse NK AU - Hebebrand D AI - Paprottka, Felix J; ORCID: https://orcid.org/0000-0002-6481-9504 FA - Paprottka, Felix J FA - Krezdorn, Nicco FA - Sorg, Heiko FA - Konneker, Soren FA - Bontikous, Stiliano FA - Robertson, Ian FA - Schlett, Christopher L FA - Dohse, Nils-Kristian FA - Hebebrand, Detlev IN - Paprottka, Felix J. Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, Agaplesion Diakonieklinikum Rotenburg, Elise-Averdieck-Strase 17, 27356 Rotenburg (Wumme), Germany. IN - Krezdorn, Nicco. Harvard Medical School, Brigham and Women's Hospital, Department of Surgery, Division of Plastic Surgery, 75 Francis Street, Boston, MA 02115, USA. IN - Sorg, Heiko. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, Alfried Krupp Krankenhaus, Hellweg 100, 45276 Essen, Germany. IN - Konneker, Soren. Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neubergstrase 1, 30625 Hannover, Germany. IN - Bontikous, Stiliano. Department of Pathology, Agaplesion Diakonieklinikum Rotenburg, Elise-Averdieck-Strase 17, 27356 Rotenburg, Germany. IN - Robertson, Ian. Department of Surgery, Royal Brompton Hospital, Sydney St, London, UK. IN - Schlett, Christopher L. Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. IN - Dohse, Nils-Kristian. Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, Agaplesion Diakonieklinikum Rotenburg, Elise-Averdieck-Strase 17, 27356 Rotenburg (Wumme), Germany. IN - Hebebrand, Detlev. Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, Agaplesion Diakonieklinikum Rotenburg, Elise-Averdieck-Strase 17, 27356 Rotenburg (Wumme), Germany. TI - Evaluation of Complication Rates after Breast Surgery Using Acellular Dermal Matrix: Median Follow-Up of Three Years. SO - Plastic Surgery International Print. 2017:1283735, 2017 AS - Plast Surg Int. 2017:1283735, 2017 NJ - Plastic surgery international VO - 2017 PG - 1283735 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101578808 IO - Plast Surg Int CP - United States AB - INTRODUCTION: Acellular dermal matrices (ADMs) are now commonly used for breast reconstruction surgery. There are various products available: ADMs derived from human (HADM), porcine (PADM), or bovine (BADM) sources. Detailed long-term follow-up studies are necessary to detect differences in complication rates between these products. AB - MATERIAL AND METHODS: From 2010 to 2015, forty-one patients underwent 52 ADM-breast reconstructions in our clinic, including oncologic breast reconstructions and breast augmentation revisions (n = 52). 15x HADMs (Epiflex/DIZG), 21x PADMs (Strattice/LifeCell), and 16x BADMs (Tutomesh/RTI Surgical) were implanted. Retrospective data collection with median follow-up of 36 months (range: 12-54 months) was performed. AB - RESULTS: Overall complication rate was 17% after ADM implantation (HADM: 7%; PADM: 14%; BADM: 31%). In a composite endpoint of complications and Red Breast Syndrome, a lower event probability was observed between BADMs, PADMs, and HADMs (44%, 19%, and 7%, resp.; p = 0.01 for the trend). Furthermore, capsular contracture occurred in 6%, more frequently as compared to the current literature. AB - CONCLUSIONS: When ADM-based reconstruction is indicated, the authors suggest primarily the use of HADMs and secondary the use of PADMs. It is shown that BADMs have the highest complication probability within our patient cohort; nevertheless, BADMs convey physical advantages in terms of flexibility and better aesthetic outcomes. The indication for the use of ADMs should be filled for each case individually. IS - 2090-1461 IL - 2090-1461 DO - https://dx.doi.org/10.1155/2017/1283735 PT - Journal Article ID - 10.1155/2017/1283735 [doi] ID - PMC5485347 [pmc] PP - ppublish PH - 2017/01/13 [received] PH - 2017/05/11 [accepted] LG - English EP - 20170612 DP - 2017 EZ - 2017/07/12 06:00 DA - 2017/07/12 06:01 DT - 2017/07/12 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28695010 <566. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28671886 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Ollech CJ AU - Block LM AU - Afifi AM AU - Poore SO FA - Ollech, Caleb J FA - Block, Lisa M FA - Afifi, Ahmed M FA - Poore, Samuel O IN - Ollech, Caleb J. From the *Department of Surgery, University of Wisconsin, Madison, WI; and +Department of Surgery, Cairo University, Cairo, Egypt. TI - Effect of Drain Placement on Infection, Seroma, and Return to Operating Room in Expander-Based Breast Reconstruction. SO - Annals of Plastic Surgery. 79(6):536-540, 2017 Dec AS - Ann Plast Surg. 79(6):536-540, 2017 Dec NJ - Annals of plastic surgery VO - 79 IP - 6 PG - 536-540 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - INTRODUCTION: There is significant variability in the location and management of drains in breast reconstruction, with most surgeons attempting to shorten the duration of drains while preventing complications possibly related to early removal. The aim of this work was to compare our experiences with placement of 1 versus 2 drains in tissue expander breast reconstruction. AB - METHODS: This is a retrospective cohort study comparing 2 groups of patients after breast tissue expander placement in a complete submuscular pocket and without the use of acellular dermal matrix. In the first group, a single subcutaneous drain was placed; in the second group, both a subcutaneous and a submuscular drain were placed. These groups were evaluated on their relative duration of drain placement, incidence of seroma formation, incidence of infection, and rates of complication necessitating return to operating room (OR). AB - RESULTS: The single-drain group was found to have a significantly shorter duration of drain placement (14.58 vs 22.84 days, P = < 0.01) as well as lower incidence of return to OR for complications after expander placement (8.3% vs 17.6%, P = 0.040), with no difference in rate of seroma formation (6.9% vs 14.7%, P = 0.114) or infection (1.4% in the single-drain group vs 8.8% in the 2-drain group, P = 0.054). AB - CONCLUSIONS: Compared with a two-drain approach, a single subcutaneous drain yields shorter total duration of drain placement and lower rate of complications requiring return to OR while not resulting in higher rates of seroma or infection. It has become our standard approach to use a single subcutaneous drain in patients having a breast tissue expander placed in a submuscular pocket. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001174 PT - Journal Article ID - 10.1097/SAP.0000000000001174 [doi] PP - ppublish LG - English DP - 2017 Dec EZ - 2017/07/04 06:00 DA - 2017/07/04 06:00 DT - 2017/07/04 06:00 YR - 2017 RD - 20171108 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28671886 <567. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28663773 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Zenn M AU - Venturi M AU - Pittman T AU - Spear S AU - Gurtner G AU - Robb G AU - Mesbahi A AU - Dayan J FA - Zenn, Michael FA - Venturi, Mark FA - Pittman, Troy FA - Spear, Scott FA - Gurtner, Geoffrey FA - Robb, Geoffrey FA - Mesbahi, Alex FA - Dayan, Joseph IN - Zenn, Michael. CARE Plastic Surgery, Cary, NC. IN - Venturi, Mark. Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC. IN - Pittman, Troy. Plastic and Reconstructive Surgery, Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC. IN - Spear, Scott. Private Practice Plastic Surgery, Chevy Chase, MD. IN - Gurtner, Geoffrey. Department of Plastic Surgery, Stanford University, Palo Alto, Calif. IN - Robb, Geoffrey. Department of Plastic Surgery, MD Anderson Cancer Center, Houston, Tex. IN - Mesbahi, Alex. Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC. IN - Dayan, Joseph. Department of Plastic Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY. TI - Optimizing Outcomes of Postmastectomy Breast Reconstruction With Acellular Dermal Matrix: A Review of Recent Clinical Data. SO - Eplasty [Electronic Resource]. 17:e18, 2017 AS - Eplasty. 17:e18, 2017 NJ - Eplasty VO - 17 PG - e18 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101316107 IO - Eplasty CP - United States KW - ADM; AlloDerm; DermACELL; ICG; NSM AB - Background: This article reports on the current use of acellular dermal matrix in breast reconstruction. Methods: A literature review of articles on acellular dermal matrix in breast reconstruction from January 1, 2010, through December 20, 2016, was performed and analyzed for trends in acellular dermal matrix use and differences between commonly used acellular dermal matrixes. Findings: Clinical findings varied but include improved cosmesis and more 1-stage reconstructions using acellular dermal matrix. Superiority of sterile versus aseptic acellular dermal matrixes was noted, and the increased incidence of red breast syndrome with AlloDerm was significant. The cost-effectiveness of acellular dermal matrix use despite increased upfront costs was also highlighted. Finally, the article emphasizes the importance of well-vascularized mastectomy flaps and the use of indocyanine green angiography as an adjunct in immediate reconstruction with acellular dermal matrix. IS - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC5475305 [pmc] PP - epublish LG - English EP - 20170612 DP - 2017 EZ - 2017/07/01 06:00 DA - 2017/07/01 06:01 DT - 2017/07/01 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28663773 <568. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28573099 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Grassetti L AU - Torresetti M AU - Scalise A AU - Lazzeri D AU - Di Benedetto G FA - Grassetti, Luca FA - Torresetti, Matteo FA - Scalise, Alessandro FA - Lazzeri, Davide FA - Di Benedetto, Giovanni IN - Grassetti, Luca. Department of Plastic and Reconstructive Surgery, Marche Polytechnic Medical School, Ancona, Italy. IN - Torresetti, Matteo. Department of Plastic and Reconstructive Surgery, Marche Polytechnic Medical School, Ancona, Italy. IN - Scalise, Alessandro. Department of Plastic and Reconstructive Surgery, Marche Polytechnic Medical School, Ancona, Italy. IN - Lazzeri, Davide. Plastic and Reconstructive Surgery Unit, Villa Salaria Clinic, Rome, Italy. IN - Di Benedetto, Giovanni. Department of Plastic and Reconstructive Surgery, Marche Polytechnic Medical School, Ancona, Italy. TI - Acellular Dermal Matrices and Paraffinoma: A Modern Tool for a Nearly Obsolete Disease. SO - Archives of Plastic Surgery. 44(3):234-237, 2017 May AS - Arch. plast. surg.. 44(3):234-237, 2017 May NJ - Archives of plastic surgery VO - 44 IP - 3 PG - 234-237 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg CP - Korea (South) KW - Acellular dermal; Knee; Paraffinoma AB - Paraffinoma is a destructive complication of paraffin oil injection, usually associated with massive tissue destruction, thus requiring radical surgery and subsequent complex reconstruction. Although breast and penile paraffinomas have been widely described and their management is quite standardized, paraffinomas of the knee are still rare and only few case reports or small case series are available in the current literature. We describe the case of a 77-year-old man with a large paraffinoma of the right knee that occurred after self-injection of paraffin oil, 58 years before. He underwent wide surgical resection of the soft tissues overlying the knee and subsequent two-stage reconstruction by using acellular dermal matrix and, after 20 days, split-thickness skin grafts. Follow-up after 16 months showed no signs of skin ulcerations or inflammation, with an overall improvement in function. Even though conventional flap reconstructions may be still useful, the authors believe that acellular dermal matrices represent a safe, reliable, and less invasive alternative for challenging soft tissue reconstructions even in elderly patients with multiple medical problems. CI - No potential conflict of interest relevant to this article was reported. IS - 2234-6163 IL - 2234-6163 DO - https://dx.doi.org/10.5999/aps.2017.44.3.234 PT - Journal Article ID - 10.5999/aps.2017.44.3.234 [doi] ID - PMC5447534 [pmc] PP - ppublish PH - 2016/05/27 [received] PH - 2016/08/24 [revised] PH - 2016/08/31 [accepted] LG - English EP - 20170522 DP - 2017 May EZ - 2017/06/03 06:00 DA - 2017/06/03 06:01 DT - 2017/06/03 06:00 YR - 2017 RD - 20170606 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28573099 <569. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28526188 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Gschwantler-Kaulich D AU - Schrenk P AU - Bjelic-Radisic V AU - Unterrieder K AU - Leser C AU - Fink-Retter A AU - Salama M AU - Singer C FA - Gschwantler-Kaulich, D FA - Schrenk, P FA - Bjelic-Radisic, V FA - Unterrieder, K FA - Leser, C FA - Fink-Retter, A FA - Salama, M FA - Singer, C IN - Gschwantler-Kaulich, D. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: daphne.gschwantler@kaulich.at. IN - Schrenk, P. AKH Linz Breast Cancer Center, Krankenhausstrasse 9, 4021 Linz, Austria. IN - Bjelic-Radisic, V. Medical University of Graz, Department of Gynaecology, Auenbruggerplatz 1, 8036 Graz, Austria. IN - Unterrieder, K. Private Hospital Villach, Breast Cancer Center, Department of Gynaecology, Dr.-Walter-Hochsteiner-Strase 4, 9504 Villach, Austria. IN - Leser, C. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. IN - Fink-Retter, A. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. IN - Salama, M. Otto Wagner Hospital, Department of Surgery, Baumgartner Hoehe 1, 1140 Vienna, Austria. IN - Singer, C. Medical University of Vienna, Breast Cancer Center, Department of Gynaecological Oncology, Waehringer Guertel 18-20, 1090 Vienna, Austria. TI - Corrigendum to "Mesh versus acellular dermal matrix in immediate implant-based breast reconstruction - A prospective randomized trial" [Eur J Surg Oncol 42 (5) (2016) 665-671].[Erratum for Eur J Surg Oncol. 2016 May;42(5):665-71; PMID: 26947961] SO - European Journal of Surgical Oncology. 43(7):1380-1381, 2017 07 AS - Eur J Surg Oncol. 43(7):1380-1381, 2017 07 NJ - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology VO - 43 IP - 7 PG - 1380-1381 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 8504356, eur IO - Eur J Surg Oncol CP - England ES - 1532-2157 IL - 0748-7983 DI - S0748-7983(17)30477-8 DO - https://dx.doi.org/10.1016/j.ejso.2017.05.001 PT - Journal Article PT - Published Erratum ID - S0748-7983(17)30477-8 [pii] ID - 10.1016/j.ejso.2017.05.001 [doi] PP - ppublish LG - English EP - 20170516 DP - 2017 07 EZ - 2017/05/21 06:00 DA - 2017/05/21 06:01 DT - 2017/05/21 06:00 YR - 2017 RD - 20170907 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28526188 <570. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28515964 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lee CU AU - Bobr A AU - Torres-Mora J FA - Lee, Christine U FA - Bobr, Aleh FA - Torres-Mora, Jorge IN - Lee, Christine U. Department of Radiology, Mayo Clinic, Rochester, MN, USA. IN - Bobr, Aleh. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. IN - Torres-Mora, Jorge. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. TI - Radiologic-Pathologic Correlation: Acellular Dermal Matrix (Alloderm) Used in Breast Reconstructive Surgery. SO - Journal of Clinical Imaging Science. 7:13, 2017 AS - J Clin Imaging Sci. 7:13, 2017 NJ - Journal of clinical imaging science VO - 7 PG - 13 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101564708 IO - J Clin Imaging Sci CP - India KW - Acellular dermal matrix; Alloderm; biopsy; pathology; ultrasound AB - Acellular dermal matrix (ADM) such as Alloderm is sometimes used in tissue reconstruction in primary and reconstructive breast surgeries. As ADM is incorporated into the native tissues, the evolving imaging findings that would correlate with varying degrees of host migration and neoangiogenesis into the matrix can be challenging to recognize. In the setting of a palpable or clinical area of concern after breast reconstructive surgery following breast cancer, confident diagnosis of a mass representing ADM rather than recurring or developing disease can be challenging. Such diagnostic imaging uncertainties generally result in short-term imaging and clinical follow-up, but occasionally, biopsy is performed for histopathological confirmation of benignity. A case of biopsy-proven Alloderm is described. To the best of our knowledge, this is the first radiologic-pathologic correlation of ADM in the literature. CI - There are no conflicts of interest. IS - 2156-7514 IL - 2156-5597 DO - https://dx.doi.org/10.4103/jcis.JCIS_7_17 PT - Journal Article ID - 10.4103/jcis.JCIS_7_17 [doi] ID - JCIS-7-13 [pii] ID - PMC5385699 [pmc] PP - epublish PH - 2017/01/27 [received] PH - 2017/02/17 [accepted] LG - English EP - 20170328 DP - 2017 EZ - 2017/05/19 06:00 DA - 2017/05/19 06:01 DT - 2017/05/19 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28515964 <571. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28509698 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Lee KT AU - Mun GH FA - Lee, Kyeong-Tae FA - Mun, Goo-Hyun IN - Lee, Kyeong-Tae. From the Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. TI - A Meta-analysis of Studies Comparing Outcomes of Diverse Acellular Dermal Matrices for Implant-Based Breast Reconstruction. SO - Annals of Plastic Surgery. 79(1):115-123, 2017 Jul AS - Ann Plast Surg. 79(1):115-123, 2017 Jul NJ - Annals of plastic surgery VO - 79 IP - 1 PG - 115-123 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - BACKGROUND: The current diversity of the available acellular dermal matrix (ADM) materials for implant-based breast reconstruction raises the issue of whether there are any differences in postoperative outcomes according to the kind of ADM used. The present meta-analysis aimed to investigate whether choice of ADM products can affect outcomes. AB - METHODS: Studies that used multiple kinds of ADM products for implant-based breast reconstruction and compared outcomes between them were searched. Outcomes of interest were rates of postoperative complications: infection, seroma, mastectomy flap necrosis, reconstruction failure, and overall complications. AB - RESULTS: A total of 17 studies met the selection criteria. There was only 1 randomized controlled trial, and the other 16 studies had retrospective designs. Comparison of FlexHD, DermaMatrix, and ready-to-use AlloDerm with freeze-dried AlloDerm was conducted in multiple studies and could be meta-analyzed, in which 12 studies participated. In the meta-analysis comparing FlexHD and freeze-dried AlloDerm, using the results of 6 studies, both products showed similar pooled risks for all kinds of complications. When comparing DermaMatrix and freeze-dried AlloDerm with the results from 4 studies, there were also no differences between the pooled risks of complications of the two. Similarly, the meta-analysis of 4 studies comparing ready-to-use and freeze-dried AlloDerm demonstrated that the pooled risks for the complications did not differ. AB - CONCLUSIONS: This meta-analysis demonstrates that the 3 recently invented, human cadaveric skin-based products of FlexHD, DermaMatrix, and ready-to-use AlloDerm have similar risks of complications compared with those of freeze-dried AlloDerm, which has been used for longer. However, as most studies had low levels of evidence, further investigations are needed. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001085 PT - Journal Article ID - 10.1097/SAP.0000000000001085 [doi] PP - ppublish LG - English DP - 2017 Jul EZ - 2017/05/17 06:00 DA - 2017/05/17 06:00 DT - 2017/05/17 06:00 YR - 2017 RD - 20170613 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28509698 <572. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28509694 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Woo KJ AU - Park JW AU - Mun GH AU - Pyon JK AU - Jeon BJ AU - Bang SI FA - Woo, Kyong-Je FA - Park, Jin-Woo FA - Mun, Goo-Hyun FA - Pyon, Jai-Kyong FA - Jeon, Byung-Joon FA - Bang, Sa Ik IN - Woo, Kyong-Je. From the *Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; and +Department of Plastic Surgery, Ewha Womans University Mokdong Hospital, Seoul, South Korea. TI - Does the Use of Acellular Dermal Matrix Increase Postoperative Complications of the First-Stage Reconstruction of Immediate Expander-Implant Breast Reconstruction: A Matched Cohort Study. SO - Annals of Plastic Surgery. 79(4):341-345, 2017 Oct AS - Ann Plast Surg. 79(4):341-345, 2017 Oct NJ - Annals of plastic surgery VO - 79 IP - 4 PG - 341-345 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - PURPOSE: Controversy exists regarding complications associated with the use of acellular dermal matrix (ADM). This likely stems from the heterogeneous and unmatched patient characteristics in study groups. The purpose of this study was to analyze complications in a matched cohort to identify whether ADM use increased postoperative complications of the first-stage immediate expander-implant breast reconstructions. AB - METHODS: A retrospective matched-cohort study was performed. We retrospectively reviewed prospectively collected data from patients who underwent immediate expander-implant breast reconstruction after mastectomy between February 2010 and January 2016. Independent variables included clinical characteristics, mastectomy weight, mastectomy type, expander size, initial inflation volume, number of days to drain removal, and adjuvant or neoadjuvant therapies. Different independent variables between the ADM and non-ADM groups were used for propensity score matching. After matching, a pairwise comparison of the 2 cohorts' independent variables was carried out using the Wilcoxon signed rank test and McNemar test. Incidence of complications was evaluated for the 2 matched cohorts. To adjust for ablative and reconstructive surgeons, a multivariable generalized estimating equation analysis was performed. AB - RESULTS: A total of 574 immediate expander-implant breast reconstructions in 533 patients were included in this study. We identified 398 reconstructions (199 for each group; ADM and non-ADM group) of matched cohorts using propensity score matching. Characteristics were similar between the 2 matched cohorts. In the matched analysis, there were no significant differences in the rate of skin flap complications (16.1% vs 16.1%, P > 0.999), seroma (4.0% vs 8.5%, P = 0.065), infection (3.0% vs 3.5%, P = 0.781), and overall complications (21.1% vs 26.1%, P = 0.251). Acellular dermal matrix was not associated with increased risk of complication when ablative and reconstructive surgeon factors were considered in a multivariable analysis (P = 0.511). AB - CONCLUSIONS: A matched cohort analysis demonstrated that ADM usage is not associated with an increased risk of complications, including skin flap complications, seroma, and infection. Our result suggests that ADM can be safely used in immediate expander-implant breast reconstruction when necessary. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001067 PT - Journal Article ID - 10.1097/SAP.0000000000001067 [doi] PP - ppublish LG - English DP - 2017 Oct EZ - 2017/05/17 06:00 DA - 2017/05/17 06:00 DT - 2017/05/17 06:00 YR - 2017 RD - 20170913 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28509694 <573. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28495572 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Fernando EJ AU - Eskenazi BR AU - Djohan RS AU - Grobmyer SR FA - Fernando, Emil J FA - Eskenazi, Benjamin R FA - Djohan, Risal S FA - Grobmyer, Stephen R IN - Fernando, Emil J. Division of Surgical Oncology, Department of General Surgery, Cleveland Clinic, Cleveland, OH. IN - Eskenazi, Benjamin R. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH. IN - Djohan, Risal S. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH. IN - Grobmyer, Stephen R. Division of Surgical Oncology, Department of General Surgery, Cleveland Clinic, Cleveland, OH. Electronic address: grobmys@ccf.org. TI - A Tumor Ultrasound-guided Incision (TUGI) Approach to Nipple-sparing Mastectomy: Balancing Oncologic Safety and Technical Outcomes. SO - Clinical Breast Cancer. 17(7):572-577, 2017 Nov AS - Clin Breast Cancer. 17(7):572-577, 2017 Nov NJ - Clinical breast cancer VO - 17 IP - 7 PG - 572-577 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100898731 IO - Clin. Breast Cancer CP - United States KW - Breast cancer; Breast reconstruction; Incision; Margins; Total skin sparing mastectomy AB - BACKGROUND: Nipple-sparing mastectomy (NSM) is a prevalent operation for patients with breast cancer. Indications have been limited to tumors accessible via radial, infra-mammary, or periareolar incisions out of concern for oncologic and technical safety. We study an alternative approach to NSM based on tumor ultrasound-guided incisions (TUGI) and report its oncologic and technical outcomes. AB - MATERIALS AND METHODS: A retrospective chart review examined patients who underwent TUGI NSM between 2013 and 2016. Operative notes, postoperative notes, pathology reports, and postoperative photography were analyzed. AB - RESULTS: Ninety-four patients had mastectomy with reconstruction performed over a 3-year period by the senior authors. Of those, 31 (33%) were NSM and 13 (14%) had the TUGI technique, forming the study group. The median tumor size was 1.5 cm, with a median distance from the nipple areolar complex of 5 cm. Sixty-two percent of the incisions were in the upper quadrants of the breast. Median operative time was 207 minutes. Zero patients had positive margins. One hundred percent of patients underwent immediate tissue expander placement, 46% with acellular dermal matrix. For final reconstruction, 23% had a free flap, 69% implant, and 8% are still pending. Eight percent of patients had wound infection, and 15% of patients had NAC necrosis. No cancer recurrence has been observed at a median follow-up of 17 months. AB - CONCLUSION: TUGI offers a valuable, oncologically sound alternative approach to traditional NSM. The technical results and outcomes support its use in selected patients with breast cancer undergoing NSM. Copyright © 2017 Elsevier Inc. All rights reserved. ES - 1938-0666 IL - 1526-8209 DI - S1526-8209(17)30018-6 DO - https://dx.doi.org/10.1016/j.clbc.2017.04.003 PT - Journal Article ID - S1526-8209(17)30018-6 [pii] ID - 10.1016/j.clbc.2017.04.003 [doi] PP - ppublish PH - 2017/01/15 [received] PH - 2017/04/02 [revised] PH - 2017/04/04 [accepted] LG - English EP - 20170412 DP - 2017 Nov EZ - 2017/05/13 06:00 DA - 2017/05/13 06:00 DT - 2017/05/13 06:00 YR - 2017 RD - 20171024 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28495572 <574. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28481477 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Vidya R AU - Masia J AU - Cawthorn S AU - Berna G AU - Bozza F AU - Gardetto A AU - Kolacinska A AU - Dell'Antonia F AU - Tiengo C AU - Bassetto F AU - Caputo GG AU - Governa M FA - Vidya, Raghavan FA - Masia, Jaume FA - Cawthorn, Simon FA - Berna, Giorgio FA - Bozza, Fernando FA - Gardetto, Alexander FA - Kolacinska, Agnieszka FA - Dell'Antonia, Francesco FA - Tiengo, Cesare FA - Bassetto, Franco FA - Caputo, Glenda G FA - Governa, Maurizio IN - Vidya, Raghavan. Breast Care Center, Royal Wolverhampton Hospital, Wolverhampton, UK. IN - Masia, Jaume. Plastic and Reconstructive Surgery Department, Hospital de la Santa Creu i Sant Pau (Universitat Autonoma de Barcelona), Barcelona, Spain. IN - Cawthorn, Simon. Breast Care Center, North Bristol NHS Trust, Bristol, UK. IN - Berna, Giorgio. Plastic and Reconstructive Surgery Department, Ulss 9 General Hospital, Treviso, Italy. IN - Bozza, Fernando. Breast Care Center, Venetian Oncology Institute, Padova, Italy. IN - Gardetto, Alexander. Plastic and Reconstructive Surgery Department, South Tyrol Healthcare Company, Brixen, Italy. IN - Kolacinska, Agnieszka. Department of Surgical Oncology and Head and Neck Cancer Surgery, Medical University of Lodz, Cancer Center Copernicus Memorial Hospital, Medical University of Lodz, Lodz, Poland. IN - Dell'Antonia, Francesco. Plastic and Reconstructive Surgery Department, Ulss 9 General Hospital, Treviso, Italy. IN - Tiengo, Cesare. Plastic and Reconstructive Surgery Department, University Hospital of Padua, Padua, Italy. IN - Bassetto, Franco. Plastic and Reconstructive Surgery Department, University Hospital of Padua, Padua, Italy. IN - Caputo, Glenda G. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. IN - Governa, Maurizio. Plastic and Reconstructive Surgery, Surgery and Odontology Department, University Hospital of Verona, Verona, Italy. TI - Evaluation of the effectiveness of the prepectoral breast reconstruction with Braxon dermal matrix: First multicenter European report on 100 cases. SO - Breast Journal. 23(6):670-676, 2017 Nov AS - Breast J. 23(6):670-676, 2017 Nov NJ - The breast journal VO - 23 IP - 6 PG - 670-676 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J CP - United States KW - acellular dermal matrix; breast reconstruction; muscle-sparing; pectoralis muscle; prepectoral AB - We report the outcomes of the European prospective study on prepectoral breast reconstruction using preshaped acellular dermal matrix for complete breast implant coverage. Seventy-nine patients were enrolled between April 2014 and August 2015 all over Europe using a single protocol for patient selection and surgical procedure, according to the Association of Breast Surgery and British Association of Plastic Reconstructive and Aesthetic Surgeons joint guidelines for the use of acellular dermal matrix in breast surgery. The preshaped matrix completely wraps the breast implant, which is placed above the pectoralis major, without detaching the muscle. A total of 100 prepectoral breast reconstructions with complete implant coverage were performed. This series, with mean follow-up of 17.9 months, had two cases of implant loss (2.0%) including one necrosis of the nipple and one wound breakdown (1.0% respectively). No implant rotations were observed. Good cosmetic outcomes were obtained with natural movement of the breasts and softness to the touch; none of the patients reported experiencing pain or reduction in the movements of the pectoralis major muscle postoperatively. The use of preshaped acellular dermal matrix for a complete breast implant coverage in selected patients is safe and gives satisfactory results, both from the aesthetic view point and the low postoperative complication rates. Further studies reporting long-term outcomes are planned. Copyright © 2017 Crown copyright. The Breast Journal © 2017 Wiley Periodicals, Inc. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland. ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12810 PT - Journal Article ID - 10.1111/tbj.12810 [doi] PP - ppublish PH - 2016/06/08 [received] PH - 2016/08/09 [revised] PH - 2016/08/17 [accepted] LG - English EP - 20170508 DP - 2017 Nov EZ - 2017/05/10 06:00 DA - 2017/05/10 06:00 DT - 2017/05/09 06:00 YR - 2017 RD - 20171107 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28481477 <575. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28374296 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Ciancio F AU - Parisi D AU - Portincasa A AU - Innocenti A FA - Ciancio, Francesco FA - Parisi, Domenico FA - Portincasa, Aurelio FA - Innocenti, Alessandro IN - Ciancio, Francesco. Department of Plastic and Reconstructive Surgery, University of Bari, Viale Luigi Pinto n 1, 71122, Foggia, Italy. francescociancio01@gmail.com. IN - Parisi, Domenico. Department of Plastic and Reconstructive Surgery, University of Foggia, Foggia, Italy. IN - Portincasa, Aurelio. Department of Plastic and Reconstructive Surgery, University of Foggia, Foggia, Italy. IN - Innocenti, Alessandro. Plastic and Reconstructive Microsurgery, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. TI - Innovative Management of Implant Exposure in ADM/Implant-Based Breast Reconstruction with Negative Pressure Wound Therapy. SO - Aesthetic Plastic Surgery. 41(5):1237-1238, 2017 Oct AS - Aesthetic Plast Surg. 41(5):1237-1238, 2017 Oct NJ - Aesthetic plastic surgery VO - 41 IP - 5 PG - 1237-1238 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Bacterial Load; Breast Reconstruction; Negative Pressure; Pressure System; Saline Solution ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0850-y PT - Journal Article ID - 10.1007/s00266-017-0850-y [doi] ID - 10.1007/s00266-017-0850-y [pii] PP - ppublish PH - 2017/02/21 [received] PH - 2017/03/06 [accepted] LG - English EP - 20170403 DP - 2017 Oct EZ - 2017/04/05 06:00 DA - 2017/04/05 06:00 DT - 2017/04/05 06:00 YR - 2017 RD - 20171117 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28374296 <576. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28364524 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Kolker AR AU - Piccolo PP FA - Kolker, Adam R FA - Piccolo, Paulo P IN - Kolker, Adam R. Dubin Breast Center and Department of Surgery, Division of Plastic Surgery, Icahn School of Medicine at Mount Sinai, New York, USA. IN - Piccolo, Paulo P. Dubin Breast Center and Department of Surgery, Division of Plastic Surgery, Icahn School of Medicine at Mount Sinai, New York, USA. TI - Extended Submuscular Implant-Based Breast Reconstruction with Pectoralis-Serratus Sling and Acellular Dermal Matrix. SO - Aesthetic Surgery Journal. 37(4):485-491, 2017 04 01 AS - Aesthet. surg. j.. 37(4):485-491, 2017 04 01 NJ - Aesthetic surgery journal VO - 37 IP - 4 PG - 485-491 PI - Journal available in: Print PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J CP - England ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sjw200 PT - Journal Article ID - 2459562 [pii] ID - 10.1093/asj/sjw200 [doi] PP - ppublish LG - English DP - 2017 04 01 EZ - 2017/04/02 06:00 DA - 2017/04/02 06:00 DT - 2017/04/02 06:00 YR - 2017 RD - 20170825 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28364524 <577. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28337618 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Data-Review AU - Accurso A AU - Rocco N AU - Mattera E AU - D'Andrea F AI - Rocco, Nicola; ORCID: http://orcid.org/0000-0001-6941-7873 FA - Accurso, Antonello FA - Rocco, Nicola FA - Mattera, Edi FA - D'Andrea, Francesco IN - Accurso, Antonello. Department of Surgery, Breast Unit, University Hospital "Federico II", Naples, Italy. IN - Rocco, Nicola. Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via S. Pansini 5, 80131, Naples, Italy. nicolarocco2003@gmail.com. IN - Mattera, Edi. Department of Clinical and Experimental Medicine Flaviano Magrassi, Clinical Medicine Hospital Unit, Ambulatory of Vulnology, Second University of Naples, Naples, Italy. IN - D'Andrea, Francesco. Department of Plastic and Reconstructive Surgery, University of Naples "Federico II", Naples, Italy. TI - Reply: Innovative Management of Implant Infection and Exposure in ADM/Implant-Based Breast Reconstruction with Negative Pressure Wound Therapy. SO - Aesthetic Plastic Surgery. 41(5):1239-1240, 2017 Oct AS - Aesthetic Plast Surg. 41(5):1239-1240, 2017 Oct NJ - Aesthetic plastic surgery VO - 41 IP - 5 PG - 1239-1240 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Breast Reconstruction; Full Description; Medical Cost; Negative Pressure; Psychological Distress ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-017-0845-8 PT - Journal Article ID - 10.1007/s00266-017-0845-8 [doi] ID - 10.1007/s00266-017-0845-8 [pii] PP - ppublish PH - 2017/03/01 [received] PH - 2017/03/01 [accepted] LG - English EP - 20170323 DP - 2017 Oct EZ - 2017/03/25 06:00 DA - 2017/03/25 06:00 DT - 2017/03/25 06:00 YR - 2017 RD - 20171117 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28337618 <578. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28295975 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Woo A AU - Harless C AU - Jacobson SR AI - Woo, Alice; ORCID: http://orcid.org/0000-0001-7383-9948 FA - Woo, Alice FA - Harless, Christin FA - Jacobson, Steven R IN - Woo, Alice. Department of Surgery Plastic, Surgery Mayo Clinic, Rochester, New York. IN - Harless, Christin. Department of Surgery Plastic, Surgery Mayo Clinic, Rochester, New York. IN - Jacobson, Steven R. Department of Surgery Plastic, Surgery Mayo Clinic, Rochester, New York. TI - Revisiting an Old Place: Single-Surgeon Experience on Post-Mastectomy Subcutaneous Implant-Based Breast Reconstruction. SO - Breast Journal. 23(5):545-553, 2017 Sep AS - Breast J. 23(5):545-553, 2017 Sep NJ - The breast journal VO - 23 IP - 5 PG - 545-553 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J CP - United States KW - breast implants; breast reconstruction; subcutaneous breast reconstruction AB - Significant advances have been made to the reconstructive tools available to plastic surgeons allowing for the re-exploration of subcutaneous breast reconstruction. The purpose of the current study is to examine the safety, efficacy, and aesthetic results of subcutaneous breast reconstruction by a single-surgeon. A retrospective chart review was performed on all patients undergoing subcutaneous implant-based breast reconstruction between April 2012 and September 2014. All implants were fully wrapped in Alloderm and placed in the subcutaneous (pre-pectoral) plane. Primary outcome was a successful subcutaneous breast reconstruction. All complications were recorded. Aesthetics of the preoperative and postoperative photographs were examined. A total of 135 breasts (79 patients) were reconstructed. Direct-to-implant reconstruction was performed in 8 patients (10%). Successful breast reconstruction was achieved for 130 breasts in 76 patients (96%). Sixty-nine patients (87%) had a course free of any unexpected event or complication. There were no patients with implant extrusion or skin necrosis requiring operative intervention. When comparing pre-mastectomy breasts with post-mastectomy reconstructions, there was an improvement in the overall aesthetic outcome. Subcutaneous post-mastectomy breast reconstruction is safe and effective with comparable complication rates to standard techniques. Yet, this minimally invasive approach does not sacrifice the aesthetic results. Long-term studies will be required to prove the durability of aesthetic results overtime. Copyright © 2017 Wiley Periodicals, Inc. ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12790 PT - Journal Article ID - 10.1111/tbj.12790 [doi] PP - ppublish LG - English EP - 20170313 DP - 2017 Sep EZ - 2017/03/16 06:00 DA - 2017/03/16 06:00 DT - 2017/03/16 06:00 YR - 2017 RD - 20170915 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28295975 <579. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28280672 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Yuen JC AU - Coleman CA AU - Erickson SW FA - Yuen, James C FA - Coleman, Cathryn A FA - Erickson, Stephen W IN - Yuen, James C. Division of Surgical Oncology, Banner MD Anderson, Gilbert, Ariz.; Department of Surgery, Baylor University Medical Center, Dallas, Tex.; and Genetic Epidemiology & Omics Research Program, RTI International, Research Triangle Park, N.C. IN - Coleman, Cathryn A. Division of Surgical Oncology, Banner MD Anderson, Gilbert, Ariz.; Department of Surgery, Baylor University Medical Center, Dallas, Tex.; and Genetic Epidemiology & Omics Research Program, RTI International, Research Triangle Park, N.C. IN - Erickson, Stephen W. Division of Surgical Oncology, Banner MD Anderson, Gilbert, Ariz.; Department of Surgery, Baylor University Medical Center, Dallas, Tex.; and Genetic Epidemiology & Omics Research Program, RTI International, Research Triangle Park, N.C. TI - Obesity-related Risk Factors in Implant-based Breast Reconstruction Using AlloDerm. SO - Plastic and Reconstructive Surgery - Global Open. 5(2):e1231, 2017 Feb AS - Plast. reconstr. surg., Glob. open. 5(2):e1231, 2017 Feb NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 2 PG - e1231 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - With a population in which 70% of the patients were overweight or obese, we reviewed retrospectively 135 breasts of 70 consecutive patients who underwent implant-based immediate breast reconstruction using freeze-dried AlloDerm as the acellular dermal matrix. Several obesity-related parameters were evaluated to determine their possible correlation to early postoperative complications. We found that breast width and surface area of AlloDerm usage correlated with the development of infection and mastectomy skin flap necrosis. Increased breast width and size of AlloDerm matrix implanted were correlated with higher rates of both minor and significant skin necrosis and of cellulitis. Body mass index was correlated with the development of cellulitis and minor and major skin necrosis but not with seroma or reconstruction failure. Preexisting breast cup size correlated with the development of seroma but not the other complications. We observed no statistically significant association between reconstruction failure and any of the parameters reviewed, but this is likely due to the small number of failures in our data set (n = 10). IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001231 PT - Journal Article ID - 10.1097/GOX.0000000000001231 [doi] ID - PMC5340487 [pmc] PP - epublish PH - 2016/11/29 [received] PH - 2016/12/20 [accepted] LG - English EP - 20170213 DP - 2017 Feb EZ - 2017/03/11 06:00 DA - 2017/03/11 06:01 DT - 2017/03/11 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28280672 <580. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28261372 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Grow JN AU - Butterworth J AU - Petty P FA - Grow, Jacob N FA - Butterworth, James FA - Petty, Paul IN - Grow, Jacob N. Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, Mo. IN - Butterworth, James. Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, Mo. IN - Petty, Paul. Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minn. TI - Alternatives to Acellular Dermal Matrix: Utilization of a Gore DualMesh Sling as a Cost-Conscious Adjunct for Breast Reconstruction. SO - Eplasty [Electronic Resource]. 17:e4, 2017 AS - Eplasty. 17:e4, 2017 NJ - Eplasty VO - 17 PG - e4 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101316107 IO - Eplasty CP - United States KW - acellular dermal matrix; breast reconstruction; cost; mesh; tissue expansion AB - Objective: This study seeks an alternative to acellular dermal matrix in 2-staged breast reconstruction while minimizing cost. It was hypothesized that use of a Gore DualMesh would allow for similar intraoperative tissue expander fill volumes, time to second-stage reconstruction, and number of postoperative fills compared with acellular dermal matrix at only a fraction of the expense. Methods: Retrospective analysis comparing Gore DualMesh (59 breasts, 34 patients), acellular dermal matrix (13 breasts, 8 patients), and total muscle coverage (25 breasts, 14 patients) for postmastectomy breast reconstruction was performed. Time to second-stage reconstruction, number of expansions, and relative initial fill volumes were compared between the 3 groups. Secondarily, complication rates were also considered, including seroma, infection, expander/implant explantation, removal of mesh, and capsular contracture. Statistical analysis was performed utilizing the Fisher exact test and the chi² test for categorical variables and the Mann-Whitney U test for continuous variables. Results: Relative initial fill volumes, number of expansions, and time to second-stage reconstruction showed no statistical difference between the acellular dermal matrix and Gore DualMesh groups (P = .494, P = .146, and P = .539, respectively). Furthermore, the Gore DualMesh group underwent significantly fewer fills (P < .001) and had a higher relative initial fill volume (P < .001) than the total muscle coverage group. The additional cost per breast as a result of including DualMesh was on average $385 versus $4287 for acellular dermal matrix. Complication rates were similar between all 3 groups without statistically significant differences. Conclusions: Gore DualMesh represents a safe alternative to acellular dermal matrix for breast reconstruction with similar aesthetic results in certain patients at a fraction of the cost. IS - 1937-5719 IL - 1937-5719 PT - Journal Article ID - PMC5314435 [pmc] PP - epublish LG - English EP - 20170210 DP - 2017 EZ - 2017/03/07 06:00 DA - 2017/03/07 06:01 DT - 2017/03/07 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28261372 <581. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28210552 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lardi AM AU - Ho-Asjoe M AU - Junge K AU - Farhadi J FA - Lardi, Alessia M FA - Ho-Asjoe, Mark FA - Junge, Klaus FA - Farhadi, Jian IN - Lardi, Alessia M. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK; ; Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland. IN - Ho-Asjoe, Mark. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK. IN - Junge, Klaus. Premier research statistics, Darmstadt, Germany. IN - Farhadi, Jian. Department of Plastic & Reconstructive Surgery, Guy's and St. Thomas Hospital, London, UK; ; Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland; ; Center for Plastic Surgery, Clinic Pyramide at the Lake, Zurich, Switzerland. TI - Capsular contracture in implant based breast reconstruction-the effect of porcine acellular dermal matrix. SO - Gland Surgery. 6(1):49-56, 2017 Feb AS - Gland surg.. 6(1):49-56, 2017 Feb NJ - Gland surgery VO - 6 IP - 1 PG - 49-56 PI - Journal available in: Print PI - Citation processed from: Print JC - 101606638 IO - Gland Surg CP - China (Republic : 1949- ) KW - Breast; acellular dermis; implant reconstruction AB - BACKGROUND: Irradiation of implant-based breast reconstructions (BR) is known to increase capsular contracture (CC) rates on average by 4-fold over non-irradiated reconstructions. The use of acellular dermal matrix (ADM) has been associated with lower CC rates in non-irradiated reconstructions (0-3%). Experimental and clinical studies suggest that ADM may also reduce CC rates in irradiated breasts. The aim of this study was to evaluate CC rates in non-irradiated and irradiated one- and two-stage BRs performed with the assistance of porcine ADM (PADM). AB - METHODS: A single centre, retrospective, cohort study was designed from December 2008 to October 2012. A total of 200 immediate implant-based BRs were performed using PADM for inferior pole reinforcement. We included non-irradiated BR with a minimum follow up of 6 month from primary surgery (one stage) or from explantation of expander and implantation of the definitive implant (two stage). Of the postoperatively irradiated BR we included patients with 1 year or more follow up time from termination of radiotherapy. CC was graded using the conventional Spear-Baker classification and modified version for irradiated BR. According to the literature Grade III and IV CC were defined as clinically significant CC. AB - RESULTS: Of 200 BRs with PADM, 122 were included in this study (84 non-irradiated and 38 irradiated). Sixty-five BR were one stage and 57 were two stage BR. Grade III/IV CC was remarkable low in non-irradiated (6%) and irradiated BR (13%). There was a non-significant trend to increased Grade III and IV CC in irradiated BR vs. non-irradiated BR (13% vs. 6%, P=0.216). In this study follow up time (P<0.001) and the stage of ADM reconstruction (two vs. one stage, P=0.022) were significant risk factors for occurrence of grade III/IV CC on univariate analysis and remained significant for the follow up time (P=0.013) and remarkable for the stages (P=0.093) in multivariate analysis. AB - CONCLUSIONS: Our data support the current clinical evidence that ADM use in implant-based BR is associated with a reduced risk of CC when compared to the standard submuscular techniques in literature. The reduced risk is maintained in the setting of radiotherapy. Two stage procedures in our study population showed increased grade III/IV CC compared to one stage procedures with or without exposure to radiation. CI - Conflicts of Interest: The authors have no conflicts of interest to declare. IS - 2227-684X IL - 2227-684X DO - https://dx.doi.org/10.21037/gs.2017.01.02 PT - Journal Article ID - 10.21037/gs.2017.01.02 [doi] ID - gs-06-01-049 [pii] ID - PMC5293652 [pmc] PP - ppublish LG - English DP - 2017 Feb EZ - 2017/02/18 06:00 DA - 2017/02/18 06:01 DT - 2017/02/18 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28210552 <582. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28203509 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Mendenhall SD AU - Anderson LA AU - Ying J AU - Boucher KM AU - Neumayer LA AU - Agarwal JP FA - Mendenhall, Shaun D FA - Anderson, Layla A FA - Ying, Jian FA - Boucher, Kenneth M FA - Neumayer, Leigh A FA - Agarwal, Jayant P IN - Mendenhall, Shaun D. The Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Department of Surgery, University of Arizona, Tucson, Ariz.; and Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, Salt Lake City, Utah. IN - Anderson, Layla A. The Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Department of Surgery, University of Arizona, Tucson, Ariz.; and Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, Salt Lake City, Utah. IN - Ying, Jian. The Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Department of Surgery, University of Arizona, Tucson, Ariz.; and Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, Salt Lake City, Utah. IN - Boucher, Kenneth M. The Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Department of Surgery, University of Arizona, Tucson, Ariz.; and Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, Salt Lake City, Utah. IN - Neumayer, Leigh A. The Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Department of Surgery, University of Arizona, Tucson, Ariz.; and Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, Salt Lake City, Utah. IN - Agarwal, Jayant P. The Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, Ill.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; Department of Surgery, University of Arizona, Tucson, Ariz.; and Division of Plastic and Reconstructive Surgery, University of Utah School of Medicine, Salt Lake City, Utah. TI - The BREASTrial Stage II: ADM Breast Reconstruction Outcomes from Definitive Reconstruction to 3 Months Postoperative. SO - Plastic and Reconstructive Surgery - Global Open. 5(1):e1209, 2017 Jan AS - Plast. reconstr. surg., Glob. open. 5(1):e1209, 2017 Jan NJ - Plastic and reconstructive surgery. Global open VO - 5 IP - 1 PG - e1209 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - BACKGROUND: The Breast Reconstruction Evaluation of Acellular Dermal Matrix as a Sling Trial is a prospective randomized trial comparing outcomes of tissue expander breast reconstruction using either AlloDerm or DermaMatrix. The trial was divided into 3 outcome stages; this study reports stage II outcomes, which are those from the time of definitive reconstruction to 3 months postoperative. AB - METHODS: A randomized trial was conducted to compare complication rates between AlloDerm and DermaMatrix groups. The impact of matrix type, age, obesity, radiation therapy, chemotherapy, and reconstruction type on complications was analyzed with regression models. AB - RESULTS: Of the 128 patients (199 breasts) who were randomly assigned into the trial, 111 patients (173 breasts) were available for analysis in stage II. There was no difference in overall rates of complications (15.4% vs 18.3%, P = 0.8) or implant loss (2.2% vs 3.7%, P = 0.5) between the AlloDerm and DermaMatrix groups, respectively. Obesity was the only significant predictor of complications on regression analysis (odds ratio, 4.31, P = 0.007). Matrix type, age, radiation therapy, chemotherapy, or reconstruction type had no impact on the incidence/severity of complications. AB - CONCLUSIONS: Acellular dermal matrix (ADM) will likely continue to have a role in breast reconstructive surgery; however, caution should be taken when using ADM because of relatively high complication rates, especially in obese patients. The particular ADM product should be selected based on individual surgeon preference, experience, and success rates. These data and forthcoming long-term outcomes from the Breast Reconstruction Evaluation of Acellular Dermal Matrix as a Sling Trial will enable surgeons to carefully weigh the risks and benefits of ADM use in breast reconstruction. IS - 2169-7574 IL - 2169-7574 DO - https://dx.doi.org/10.1097/GOX.0000000000001209 PT - Journal Article ID - 10.1097/GOX.0000000000001209 [doi] ID - PMC5293307 [pmc] PP - epublish PH - 2016/09/15 [received] PH - 2016/12/01 [accepted] LG - English EP - 20170125 DP - 2017 Jan EZ - 2017/02/17 06:00 DA - 2017/02/17 06:01 DT - 2017/02/17 06:00 YR - 2017 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28203509 <583. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28099173 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - In-Process AU - Laforgia R AU - Punzo C AU - Panebianco A AU - Volpi A AU - Minafra M AU - Sederino MG FA - Laforgia, Rita FA - Punzo, Clelia FA - Panebianco, Annunziata FA - Volpi, Annalisa FA - Minafra, Marina FA - Sederino, Maria Grazia TI - Surgical approach for ulcerated locally advanced breast cancer. A single Center experience: a retrospective study. SO - Annali Italiani di Chirurgia. 88, 2017 AS - Ann Ital Chir. 88, 2017 NJ - Annali italiani di chirurgia VO - 88 PI - Journal available in: Print PI - Citation processed from: Internet JC - 5c0, 0372343 IO - Ann Ital Chir CP - Italy AB - AIM: The aim of our retrospective study is to analyze surgical possibilities for the extended LABC in those cases not suitable for a neoadjuvant chemotherapy step and to consider various reconstruction techniques. AB - MATERIAL OF STUDY: Between 2009 and 2015 we enrolled 11 patients, admitted to the Emergency Department, presenting ulcerated LABC that needed palliative surgical demolitive procedures because of bleeding and anemia and in which was necessary to use natural tissues transposition or synthetic substitutes for the reconstruction of the skin flaps. AB - RESULTS: The mean follow up was 12 months. Mortality rate was 82% (9 patients); in 2 cases there was local relapse after 6 months; 9 months was the longest disease free survival. AB - DISCUSSION: Thanks to multidisciplinary strategies LABC's surgical treatment improved results with a five-year survival rate between 30-40% and better quality of survival. Despite extended demolitive approach, there is still a 50% of death because of metastases. AB - CONCLUSIONS: Our results confirm that musculocutaneous flap, skin anterior thigh grafts, bilayer matrix wound dressing are excellent reconstructive strategies in locally advanced ulcerated breast cancer after aggressive extended surgery even if palliative to improve patients' further survival. Our data also showed that those patients presenting medium level of malignancy as "luminal b" subtype (7 patients) if treated earlier with a radical surgical procedure would have better prognosis. AB - KEY WORDS: Oncoplastic techniques, Ulcerated breast cancer. OA - Publisher: L'obiettivo del nostro studio e la valutazione della strategia chirurgica piu idonea nei casi di LABC (Locally Advanced Breast Cancer) in condizioni di ulcerazione e sanguinamento. La diagnosi clinica del LABC prevede nella maggior parte dei casi una massa mammaria estesa associata ad edema, eritema, retrazione e sanguinamento, dolore, superficie cutanea irregolare e coinvolgimento linfonodale. L'intervento chirurgico di scelta per le forme T3-T4 e la mastectomia radicale che rappresenta un trattamento adeguato per il controllo locale della patologia. In caso di forme localmente avanzate e ulcerate, pur essendo forme inoperabili, l'exeresi chirurgica si rende necessaria per una bonifica locale. La presenza di fenomeni di ulcerazione e sanguinamento non rende possibile avviare un trattamento chemioterapico neoadiuvante ed e necessario eseguire interventi chirurgici palliativi. Il trattamento chirurgico stesso richiede mutilazioni ampie ed associate procedure di chirurgia plastica. Spesso per l'estensione della malattia ed il sovvertimento del corpus mammae durante l'exeresi chirurgica della mammella, la sezione su zone esenti da neoplasia non consente la chiusura immediata dei lembi. Abbiamo considerato, su un campione di 288 pazienti affette da carcinoma mammario, 11 donne con forme avanzate fra T4a e T4c (3.8%). E' stata posta indicazione a trattamento chirurgico perche pazienti provenienti dal Pronto Soccorso con anemizzazione per neoplasie avanzate ulcerate e sanguinanti, non candidabili in prima istanza a chemioterapia neoadiuvante citoriduttiva. Le procedure adoperate per la ricostruzione della mammella sono state in 2 pazienti la rotazione di un lembo muscolo cutaneo, in 4 casi un innesto cutaneo prelevato dalla coscia, in 4 casi e stata utilizzata una matrice dermica biologica - sostituto cutaneo (INTEGRA) che e stata poi sostituita con un successivo innesto cutaneo a distanza di circa 20-30 giorni. Sono state osservate recidive in 2 casi dopo 6 mesi dal trattamento ed exitus dopo 8 mesi dalla diagnosi primaria. In queste pazienti l'obiettivo principale e migliorare la qualita di vita e la gestione della malattia stessa e il chirurgo si trova di fronte al dilemma se affidarle ad un trattamento chemioterapico in prima istanza. Nel nostro studio retrospettivo il follow-up e stato breve, proprio perche essendo forme avanzate le pazienti non avevano una lunga aspettativa di vita e sono comunque decedute a distanza di pochi mesi (4 - 9 mesi) rendendo difficile la redazione di un database sulla qualita della vita. I nostri risultati confermano che l'innesto cutaneo e il sostituto acellulare biologico sono valide opzioni di ricostruzione nelle pazienti con carcinoma mammario localmente avanzato esteso, per migliorare la qualita della vita.; Language: Italian ES - 2239-253X IL - 0003-469X DI - S0003469X1702615X PT - Journal Article ID - S0003469X1702615X [pii] PP - ppublish LG - English DP - 2017 EZ - 2017/01/19 06:00 DA - 2017/01/19 06:00 DT - 2017/01/19 06:00 YR - 2017 RD - 20170612 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28099173 <584. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 28105410 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Knabben L AU - Kanagalingam G AU - Imboden S AU - Gunthert AR FA - Knabben, Laura FA - Kanagalingam, Gowthami FA - Imboden, Sara FA - Gunthert, Andreas R IN - Knabben, Laura. Department of Obstetrics and Gynaecology, University Hospital of Berne, University of Berne , Berne , Switzerland. IN - Kanagalingam, Gowthami. Department of Obstetrics and Gynaecology, University Hospital of Berne, University of Berne , Berne , Switzerland. IN - Imboden, Sara. Department of Obstetrics and Gynaecology, University Hospital of Berne, University of Berne , Berne , Switzerland. IN - Gunthert, Andreas R. Department of Obstetrics and Gynaecology, Cantonal Hospital of Lucerne , Lucerne , Switzerland. TI - Acellular Dermal Matrix (Permacol) for Heterologous Immediate Breast Reconstruction after Skin-Sparing Mastectomy in Patients with Breast Cancer: A Single-Institution Experience and a Review of the Literature. SO - Frontiers in Medicine. 3:72, 2016 AS - Front Med (Lausanne). 3:72, 2016 NJ - Frontiers in medicine VO - 3 PG - 72 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101648047 IO - Front Med (Lausanne) CP - Switzerland KW - Permacol; acellular dermal matrices; breast cancer; heterologous immediate breast reconstruction; skin-sparing mastectomy AB - OBJECTIVE: Skin-sparing mastectomy (SSM) with immediate heterologous reconstruction is a safe oncological option in surgical therapy of early breast cancer. Permacol is an acellular dermal matrix (ADM) placed between the implant and the skin to improve lower pole projection and implant coverage. The aim of our study was to evaluate the outcome with a focus on patient satisfaction after 6months and to analyze physical changes of ADM. AB - METHODS: 10 patients who underwent SSM with Permacol were analyzed retrospectively. All patients were followed using a satisfaction questionnaire and an ultrasound evaluation of the tissue thickness of the pectoralis muscle and the Permacol. AB - RESULTS: No intraoperative complications were observed. One patient required removal of the implant for necrosis after 3months. Half of the patients underwent secondary corrective surgery. A statistically significant thinning of the pectoralis muscle was observed, compared to the thickening of the Permacol. A majority of the patients were satisfied with the operation, and we found a correlation between lower body mass index and patient satisfaction. AB - CONCLUSION: In our small case series Permacol-assisted immediate reconstruction is shown to be an option for selected cases. Physical changes of Permacol result in a symmetrical coverage of the implant, which may improve cosmetic outcome. IS - 2296-858X IL - 2296-858X DO - https://dx.doi.org/10.3389/fmed.2016.00072 PT - Journal Article ID - 10.3389/fmed.2016.00072 [doi] ID - PMC5213735 [pmc] PP - epublish PH - 2016/10/16 [received] PH - 2016/12/16 [accepted] LG - English EP - 20170105 DP - 2016 EZ - 2017/01/21 06:00 DA - 2017/01/21 06:01 DT - 2017/01/21 06:00 YR - 2016 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=28105410 <585. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27975034 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Salibian AA AU - Frey JD AU - Choi M AU - Karp NS FA - Salibian, Ara A FA - Frey, Jordan D FA - Choi, Mihye FA - Karp, Nolan S IN - Salibian, Ara A. Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, N.Y. IN - Frey, Jordan D. Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, N.Y. IN - Choi, Mihye. Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, N.Y. IN - Karp, Nolan S. Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, N.Y. TI - Subcutaneous Implant-based Breast Reconstruction with Acellular Dermal Matrix/Mesh: A Systematic Review. SO - Plastic and Reconstructive Surgery - Global Open. 4(11):e1139, 2016 Nov AS - Plast. reconstr. surg., Glob. open. 4(11):e1139, 2016 Nov NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 11 PG - e1139 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - BACKGROUND: The availability of acellular dermal matrix (ADM) and synthetic mesh products has prompted plastic surgeons to revisit subcutaneous implant-based breast reconstruction. The literature is limited, however, with regards to evidence on patient selection, techniques, and outcomes. AB - METHODS: A systematic review of the Medline and Cochrane databases was performed for original studies reporting breast reconstruction with ADM or mesh, and subcutaneous implant placement. Studies were analyzed for level of evidence, inclusion/exclusion criteria for subcutaneous reconstruction, reconstruction characteristics, and outcomes. AB - RESULTS: Six studies (186 reconstructions) were identified for review. The majority of studies (66.7%) were level IV evidence case series. Eighty percent of studies had contraindications for subcutaneous reconstruction, most commonly preoperative radiation, high body mass index, and active smoking. Forty percent of studies commenting on patient selection assessed mastectomy flap perfusion for subcutaneous reconstruction. Forty-five percent of reconstructions were direct-to-implant, 33.3% 2-stage, and 21.5% single-stage adjustable implant, with ADM utilized in 60.2% of reconstructions versus mesh. Pooled complication rates included: major infection 1.2%, seroma 2.9%, hematoma 2.3%, full nipple-areola complex necrosis 1.1%, partial nipple-areola complex necrosis 4.5%, major flap necrosis 1.8%, wound healing complication 2.3%, explantation 4.1%, and grade III/IV capsular contracture 1.2%. AB - CONCLUSIONS: Pooled short-term complication rates in subcutaneous alloplastic breast reconstruction with ADM or mesh are low in preliminary studies with selective patient populations, though techniques and outcomes are variable across studies. Larger comparative studies and better-defined selection criteria and outcomes reporting are needed to develop appropriate indications for performing subcutaneous implant-based reconstruction. IS - 2169-7574 IL - 2169-7574 PT - Journal Article ID - 10.1097/GOX.0000000000001139 [doi] ID - PMC5142500 [pmc] PP - epublish PH - 2016/08/12 [received] PH - 2016/09/30 [accepted] LG - English EP - 20161123 DP - 2016 Nov EZ - 2016/12/16 06:00 DA - 2016/12/16 06:01 DT - 2016/12/16 06:00 YR - 2016 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27975034 <586. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27975023 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Schnarrs RH AU - Carman CM AU - Tobin C AU - Chase SA AU - Rossmeier KA FA - Schnarrs, Robert H FA - Carman, Claire M FA - Tobin, Chase FA - Chase, Serena A FA - Rossmeier, Kerri A IN - Schnarrs, Robert H. Hague Center for Cosmetic and Plastic Surgery, Norfolk, Va.; Breast Care Specialists, PC, Norfolk, Va.; Medical College of Wisconsin, Milwaukee, Wis.; and Bacterin International, Inc., Belgrade, Mont. IN - Carman, Claire M. Hague Center for Cosmetic and Plastic Surgery, Norfolk, Va.; Breast Care Specialists, PC, Norfolk, Va.; Medical College of Wisconsin, Milwaukee, Wis.; and Bacterin International, Inc., Belgrade, Mont. IN - Tobin, Chase. Hague Center for Cosmetic and Plastic Surgery, Norfolk, Va.; Breast Care Specialists, PC, Norfolk, Va.; Medical College of Wisconsin, Milwaukee, Wis.; and Bacterin International, Inc., Belgrade, Mont. IN - Chase, Serena A. Hague Center for Cosmetic and Plastic Surgery, Norfolk, Va.; Breast Care Specialists, PC, Norfolk, Va.; Medical College of Wisconsin, Milwaukee, Wis.; and Bacterin International, Inc., Belgrade, Mont. IN - Rossmeier, Kerri A. Hague Center for Cosmetic and Plastic Surgery, Norfolk, Va.; Breast Care Specialists, PC, Norfolk, Va.; Medical College of Wisconsin, Milwaukee, Wis.; and Bacterin International, Inc., Belgrade, Mont. TI - Complication Rates With Human Acellular Dermal Matrices: Retrospective Review of 211 Consecutive Breast Reconstructions. SO - Plastic and Reconstructive Surgery - Global Open. 4(11):e1118, 2016 Nov AS - Plast. reconstr. surg., Glob. open. 4(11):e1118, 2016 Nov NJ - Plastic and reconstructive surgery. Global open VO - 4 IP - 11 PG - e1118 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101622231 IO - Plast Reconstr Surg Glob Open CP - United States AB - BACKGROUND: Human acellular dermal matrix (HADM) is commonly used to provide coverage and support for breast reconstruction. The primary purpose of this study was to evaluate the complication rates associated with breast reconstruction procedures when performed in conjunction with multiple types of HADM in a consecutive series. AB - METHODS: After receiving institutional review board approval, medical records from a single surgeon were retrospectively reviewed for 126 consecutive patients (170 breasts and 211 procedures) who received a breast reconstruction or revision with implantation of HADM between 2012 and 2014. Patient demographics, surgical technique, and the complication profile of 4 major types of HADM were evaluated by procedure. Complication data were primarily evaluated for infection, seroma formation, necrosis, and other complications requiring additional surgery. AB - RESULTS: The total complication rate was 19.4%. The complication rates were not statistically different between all 4 types of HADM: Alloderm (n = 143); Alloderm RTU (n = 19); FlexHD (n = 18); hMatrix (n = 32) (P > 0.05). Smokers and large-breasted women (>=500g) had a significantly higher complication rate than the rest of the population (P < 0.01 and P < 0.03, respectively). The complication rates associated with all other patient cohorts analyzed (age, body mass index, comorbid conditions, cancer diagnosis, prepectoral technique) showed no influence on complication rates (P > 0.05). AB - CONCLUSIONS: In characteristically similar cohorts, there was no statistically significant difference in complication rates based on type of HADM; however, certain risk factors and anatomy should be considered before HADM-assisted breast reconstruction. IS - 2169-7574 IL - 2169-7574 PT - Journal Article ID - 10.1097/GOX.0000000000001118 [doi] ID - PMC5142489 [pmc] PP - epublish PH - 2016/05/13 [received] PH - 2016/09/13 [accepted] LG - English EP - 20161121 DP - 2016 Nov EZ - 2016/12/16 06:00 DA - 2016/12/16 06:01 DT - 2016/12/16 06:00 YR - 2016 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27975023 <587. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27896182 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Lee JH AU - Park Y AU - Choi KW AU - Chung KJ AU - Kim TG AU - Kim YH FA - Lee, Jun Ho FA - Park, Youngsoo FA - Choi, Kyoung Wook FA - Chung, Kyu-Jin FA - Kim, Tae Gon FA - Kim, Yong-Ha IN - Lee, Jun Ho. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Park, Youngsoo. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Choi, Kyoung Wook. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Chung, Kyu-Jin. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Kim, Tae Gon. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. IN - Kim, Yong-Ha. Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea. TI - The Effect of Sterile Acellular Dermal Matrix Use on Complication Rates in Implant-Based Immediate Breast Reconstructions. SO - Archives of Plastic Surgery. 43(6):523-528, 2016 Nov AS - Arch. plast. surg.. 43(6):523-528, 2016 Nov NJ - Archives of plastic surgery VO - 43 IP - 6 PG - 523-528 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 101577999 IO - Arch Plast Surg CP - Korea (South) KW - Acellular dermis; Breast implants; Mammaplasty AB - BACKGROUND: The use of acellular dermal matrix (ADM) in implant-based immediate breast reconstruction has been increasing. The current ADMs available for breast reconstruction are offered as aseptic or sterile. No published studies have compared aseptic and sterile ADM in implant-based immediate breast reconstruction. The authors performed a retrospective study to evaluate the outcomes of aseptic versus sterile ADM in implant-based immediate breast reconstruction. AB - METHODS: Implant-based immediate breast reconstructions with ADM conducted between April 2013 and January 2016 were included. The patients were divided into 2 groups: the aseptic ADM (AlloDerm) group and the sterile ADM (MegaDerm) group. Archived records were reviewed for demographic data and postoperative complication types and frequencies. The complications included were infection, flap necrosis, capsular contracture, seroma, hematoma, and explantation for any cause. AB - RESULTS: Twenty patients were reconstructed with aseptic ADM, and 68 patients with sterile ADM. Rates of infection (15.0% vs. 10.3%), flap necrosis (5.0% vs. 7.4%), capsular contracture (20.0% vs. 14.7%), seroma (10.0% vs. 14.7%), hematoma (0% vs. 1.5%), and explantation (10.0% vs. 8.8%) were not significantly different in the 2 groups. AB - CONCLUSIONS: Sterile ADM did not provide better results regarding infectious complications than aseptic ADM in implant-based immediate breast reconstruction. CI - No potential conflict of interest relevant to this article was reported. IS - 2234-6163 IL - 2234-6163 PT - Journal Article ID - 10.5999/aps.2016.43.6.523 [doi] ID - PMC5122540 [pmc] PP - ppublish PH - 2016/05/27 [received] PH - 2016/09/15 [revised] PH - 2016/09/28 [accepted] LG - English EP - 20161118 DP - 2016 Nov EZ - 2016/11/30 06:00 DA - 2016/11/30 06:01 DT - 2016/11/30 06:00 YR - 2016 RD - 20170224 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27896182 <588. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27878067 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - PubMed-not-MEDLINE AU - Seon Kim Y FA - Seon Kim, Young IN - Seon Kim, Young. Department of Radiology, College of Medicine, Yeungnam University, Daegu, Korea. TI - Ultrasonography Findings of AlloDerm Used in Postmastectomy Alloplastic Breast Reconstruction: A Case Report and Literature Review. SO - Iranian Journal of Radiology. 13(3):e38252, 2016 Jul AS - Iran. j. radiol.. 13(3):e38252, 2016 Jul NJ - Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society VO - 13 IP - 3 PG - e38252 PI - Journal available in: Electronic-eCollection PI - Citation processed from: Print JC - 101233229 IO - Iran J Radiol CP - Iran KW - Alloderm; Breast Reconstruction; Mastectomy; Ultrasonography AB - AlloDerm (LifeCell Corp.; Brancburg, NJ) is an acellular dermal matrix (ADM) that serves as an immunologically inert scaffold in plastic surgery. In breast reconstruction, it is used as a filler for lumpectomy defects and can be used to create the inferolateral portion of the tissue expander pocket or implant pocket in postmastectomy patients. However, there are limited reports of the radiologic findings of AlloDerm in patients who have undergone postmastectomy reconstruction. Familiarity with the imaging features of AlloDerm is essential for correct diagnosis. We report the ultrasonography features of AlloDerm in a 43-year-old female patient 3 months after postmastectomy reconstruction. It may help distinguish AlloDerm from tumor recurrence or other foreign body materials such as gossypiboma. This is important as misdiagnosis can often lead to unnecessary surgical intervention. IS - 1735-1065 IL - 1735-1065 PT - Journal Article ID - 10.5812/iranjradiol.38252 [doi] ID - PMC5110931 [pmc] PP - epublish PH - 2016/04/10 [received] PH - 2016/04/21 [accepted] LG - English EP - 20160528 DP - 2016 Jul EZ - 2016/11/24 06:00 DA - 2016/11/24 06:01 DT - 2016/11/24 06:00 YR - 2016 RD - 20170816 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=27878067 <589. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29631098 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Wu LH AU - Zhang MX AU - Chen CY AU - Fang QQ AU - Wang XF AU - Tan WQ FA - Wu, Li-Hong FA - Zhang, Min-Xia FA - Chen, Chun-Ye FA - Fang, Qing-Qing FA - Wang, Xiao-Feng FA - Tan, Wei-Qiang IN - Wu, Li-Hong. Department of Plastic Surgery, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China. IN - Zhang, Min-Xia. Department of Plastic Surgery, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China. IN - Chen, Chun-Ye. Department of Plastic Surgery, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China. IN - Fang, Qing-Qing. Department of Plastic Surgery, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China. IN - Wang, Xiao-Feng. Department of Plastic Surgery, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China. IN - Tan, Wei-Qiang. Department of Plastic Surgery, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang Province, China. Electronic address: tanweixxxx@zju.edu.cn. TI - Breast reconstruction with Alloderm Ready to Use: A meta-analysis of nine observational cohorts. SO - Breast. 39:89-96, 2018 Apr 06 AS - BREAST. 39:89-96, 2018 Apr 06 NJ - Breast (Edinburgh, Scotland) VO - 39 PG - 89-96 PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9213011 IO - Breast CP - Netherlands KW - Alloderm RTU; Allomax; Breast reconstruction; DermACELL; FD Alloderm; Meta-analysis AB - BACKGROUND: AlloDerm-RTU is a new member of human acellular dermal matrix (HADM) which was launched in 2012. The present meta-analysis aimed to investigate whether AlloDerm-RTU was superior compared with previous HADMs. AB - METHODS: All available databases were searched for retrospective or prospective studies regarding breast reconstruction with AlloDerm-RTU compared with other HADMs. The primary outcome was the incidence of complications among different HADMs. AB - RESULTS: Two prospective and seven retrospective studies with a total of 1406 patients were enrolled. There was no significant difference in any of the complications, including the incidence of hematoma (RR 0.78, 95%CI 0.19 to 3.19; P=0.73), seroma (RR 0.98, 95%CI 0.43 to 2.26; P=0.97), cellulitis (RR 0.82, 95%CI 0.32 to 2.11; P=0.68), necrosis (RR 0.69, 95%CI 0.44 to 1.10; P=0.12), infection (RR 0.68, 95%CI 0.37 to 1.25; P=0.22), explantation (RR 0.61, 95%CI 0.35 to 1.06; P=0.08), and total complications (RR 0.91, 95%CI 0.55 to 1.52; P=0.73). Subgroup analysis showed that AlloDerm-RTU demonstrated no superiority compared with FD AlloDerm, AlloMax, or DermACELL. Sensitivity analysis indicated that the outcomes were stabilized. No publication bias existed in the present meta-analysis. AB - CONCLUSION: Four HADM products, AlloDerm-RTU, FD AlloDerm, AlloMax, and DermACELL, showed similar risks of complications. However since most of the included studies had a low level of evidence, further random trials with large numbers of patients are needed. Copyright © 2018 Elsevier Ltd. All rights reserved. ES - 1532-3080 IL - 0960-9776 DI - S0960-9776(18)30055-9 DO - https://dx.doi.org/10.1016/j.breast.2018.03.007 PT - Journal Article ID - S0960-9776(18)30055-9 [pii] ID - 10.1016/j.breast.2018.03.007 [doi] PP - aheadofprint PH - 2018/01/22 [received] PH - 2018/03/10 [revised] PH - 2018/03/20 [accepted] LG - English EP - 20180406 DP - 2018 Apr 06 EZ - 2018/04/10 06:00 DA - 2018/04/10 06:00 DT - 2018/04/10 06:00 YR - 2018 RD - 20180409 UP - 20180410 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29631098 <590. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29546437 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Pantelides NM AU - Srinivasan JR FA - Pantelides, Nicholas M FA - Srinivasan, Jeyaram R IN - Pantelides, Nicholas M. Department of Plastic and Reconstructive Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital, Sharoe Green Lane, Preston, PR2 9HT, UK. nmpantelides@gmail.com. IN - Srinivasan, Jeyaram R. Department of Plastic and Reconstructive Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital, Sharoe Green Lane, Preston, PR2 9HT, UK. TI - Rippling Following Breast Augmentation or Reconstruction: Aetiology, Emerging Treatment Options and a Novel Classification of Severity. [Review] SO - Aesthetic Plastic Surgery. 2018 Mar 15 AS - Aesthetic Plast Surg. 2018 Mar 15 NJ - Aesthetic plastic surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Acellular dermal matrix; Breast augmentation; Breast reconstruction; Fat transfer; Implant rippling; Rippling AB - BACKGROUND: Implant rippling is a frequent complication following breast augmentation or implant-based reconstruction and results in significant patient dissatisfaction. Traditionally, the treatment has been to replace the implant, often placing it in a subpectoral pocket to reduce the risk of recurrence. Other techniques, such as increasing the implant size or tightening the capsule, can also be used. Recently, however, there has been much interest in alternative treatments, including fat grafting or insertion of an acellular dermal matrix. AB - METHODS: We review the evidence base for emerging treatments and propose a classification to grade severity, based on the typical clinical presentation of rippling: Grade 1-MILD-rippling is palpable but not visible: (1a) palpable in the lower outer quadrant, (1b) palpable in the upper inner quadrant (cleavage area); Grade 2-MODERATE-rippling is visible only when the patient bends forward; Grade 3-SEVERE-rippling is visible with the patient upright. AB - CONCLUSION: Our proposed classification aims to standardise the clinical description of rippling, which will be valuable in determining the efficacy of new treatments and better characterising long-term complications from breast augmentations or reconstructions. AB - LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-018-1117-y PT - Journal Article PT - Review ID - 10.1007/s00266-018-1117-y [doi] ID - 10.1007/s00266-018-1117-y [pii] PP - aheadofprint PH - 2018/01/09 [received] PH - 2018/03/04 [accepted] LG - English EP - 20180315 DP - 2018 Mar 15 DT - 2018/03/17 06:00 YR - 2018 RD - 20180316 UP - 20180316 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29546437 <591. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29365064 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Gabriel A AU - Sigalove S AU - Sigalove NM AU - Storm-Dickerson TL AU - Rice J AU - Pope N AU - Patrick Maxwell G FA - Gabriel, Allen FA - Sigalove, Steven FA - Sigalove, Noemi M FA - Storm-Dickerson, Toni L FA - Rice, Jami FA - Pope, Nicole FA - Patrick Maxwell, G IN - Gabriel, Allen. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, CA. IN - Sigalove, Steven. Department of Plastic Surgery, Central DuPage Hospital/Northwestern Medicine, Winfield IL. IN - Sigalove, Noemi M. Department of Breast Surgery, Central DuPage Hospital/Northwestern Medicine, Winfield, IL. IN - Storm-Dickerson, Toni L. Compass Oncology, Portland, OR and Vancouver, WA. IN - Rice, Jami. PeaceHealth Medical Group, Vancouver, WA. IN - Pope, Nicole. DuPage Medical Group, Winfield, IL. IN - Patrick Maxwell, G. Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, CA. TI - Prepectoral Revision Breast Reconstruction for Treatment of Implant-Associated Animation Deformity: A Review of 102 Reconstructions. SO - Aesthetic Surgery Journal. 2018 Jan 20 AS - Aesthet. surg. j.. 2018 Jan 20 NJ - Aesthetic surgery journal PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 9707469 IO - Aesthet Surg J CP - England AB - Background: Animation deformity is a direct consequence of subpectoral implant placement for breast reconstruction following mastectomy. Current treatment options ameliorate but do not address the source of the problem. Moving the implant from subpectoral to prepectoral has the potential to eliminate animation deformity. AB - Objectives: Describe the technique and outcomes of prepectoral revision reconstruction in over 100 cases and discuss patient selection criteria for a successful outcome. AB - Methods: Patients who presented with animation deformity following two-stage implant reconstruction were included in this retrospective study. Revision surgery involved removal of the existing implant via the previous incision site along the inframammary fold, suturing of the pectoralis major muscle back to the chest wall, creation of a prepectoral pocket for the new implant, use of acellular dermal matrix to reinforce the prepectoral pocket and completely cover the implant, and fat grafting to enhance soft tissue. Patients were evaluated for resolution of animation deformity and occurrence of complications during follow up. AB - Results: Fifty-seven patients (102 breasts) underwent prepectoral revision reconstruction with complete resolution of animation deformity. Complications occurred in 4 breasts (3.9%) and included seroma (2 breasts), skin necrosis (3 breasts), and wound dehiscence (1 breast). All 4 breasts with complications had their implants removed and replaced. There were no incidences of infection or clinically significant capsular contracture in this series. AB - Conclusions: Revision reconstruction with prepectoral implant placement and complete coverage with acellular dermal matrix resolves animation deformity and results in aesthetically pleasing soft breasts. Patient selection is critical for the success of this technique. AB - Level of Evidence 4: Copyright © 2018 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com ES - 1527-330X IL - 1090-820X DO - https://dx.doi.org/10.1093/asj/sjx261 PT - Journal Article ID - 4818351 [pii] ID - 10.1093/asj/sjx261 [doi] PP - aheadofprint LG - English EP - 20180120 DP - 2018 Jan 20 EZ - 2018/01/25 06:00 DA - 2018/01/25 06:00 DT - 2018/01/25 06:00 YR - 2018 RD - 20180308 UP - 20180308 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29365064 <592. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29498444 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Nahabedian MY AI - Nahabedian, Maurice Y; ORCID: http://orcid.org/0000-0002-2962-463X FA - Nahabedian, Maurice Y IN - Nahabedian, Maurice Y. Inova Fairfax Hospital, Falls Church, VA, USA. TI - Innovations and advancements with prosthetic breast reconstruction. SO - Breast Journal. 2018 Mar 02 AS - Breast J. 2018 Mar 02 NJ - The breast journal PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - d1h, 9505539 IO - Breast J CP - United States KW - acellular dermal matrix; breast implant; breast reconstruction; fat grafting; prepectoral reconstruction; radiation therapy; tissue expander AB - Prosthetic breast reconstruction has evolved over the years to provide results that now mimic that of a natural breast. This is due to a variety of innovations and advancements related to mastectomy techniques, acellular dermal matrices, autologous fat grafting, and improved breast implants. The evolution of prosthetic breast reconstruction has gone full-circle and included prepectoral placement in the 1970s and 80s, partial or total subpectoral placement from 1985 to 2015, and now gradually trending back to prepectoral. There are several techniques and strategies that now allow for patients to achieve results that are superior to any time over the past 50 years. This manuscript will review the salient aspects of prosthetic breast reconstruction and how its evolution has progressed over the years. Copyright © 2018 Wiley Periodicals, Inc. ES - 1524-4741 IL - 1075-122X DO - https://dx.doi.org/10.1111/tbj.12998 PT - Journal Article ID - 10.1111/tbj.12998 [doi] PP - aheadofprint PH - 2017/06/26 [received] PH - 2017/07/04 [revised] PH - 2017/07/06 [accepted] LG - English EP - 20180302 DP - 2018 Mar 02 DT - 2018/03/03 06:00 YR - 2018 RD - 20180302 UP - 20180302 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29498444 <593. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29481482 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Bletsis P AU - Bucknor A AU - Chattha A AU - Kamali P AU - Chen A AU - Flecha-Hirsch R AU - van der Lei B AU - Lee BT AU - Lin SJ FA - Bletsis, Patrick FA - Bucknor, Alexandra FA - Chattha, Anmol FA - Kamali, Parisa FA - Chen, Austin FA - Flecha-Hirsch, Renata FA - van der Lei, Berend FA - Lee, Bernard T FA - Lin, Samuel J TI - Evaluation of Contralateral and Bilateral Prophylactic Mastectomy and Reconstruction Outcomes: Comparing Alloplastic and Autologous Reconstruction. SO - Annals of Plastic Surgery. 2018 Feb 23 AS - Ann Plast Surg. 2018 Feb 23 NJ - Annals of plastic surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - BACKGROUND: Over the last decade, there has been a 12% increase in prophylactic mastectomy (PM) per year. The aim of the study was to analyze complication rates and associated risk factors in patients undergoing PM and reconstruction. AB - METHODS: We reviewed patients undergoing PM (contralateral and bilateral) from 2010 to 2015 at a single academic institution. Data on patient characteristics and postoperative outcomes were obtained. Postoperative complications were categorized into minor and major groups. We compared complication rates between autologous and alloplastic reconstruction. Patient characteristics were assessed using univariable and multivariable models. AB - RESULTS: Reconstruction after PM was performed on 390 breasts over the study period: 214 underwent autologous and 176 underwent alloplastic reconstruction. When comparing autologous and alloplastic reconstruction, significant differences were seen between the number of immediate breast reconstructions (96.3% vs 48.9%, P < 0.001, respectively) and 2-stage reconstructions (0.5% vs 44.9%, P < 0.001, respectively). The overall complication rate was 15.9%: 14.6% were minor complications, and 6.9% were major. Autologous reconstruction compared with alloplastic reconstruction had a lower incidence of minor complications (11.2% vs 18.8%, P = 0.036), breast infection (1.9% vs 13.1%, P < 0.001), and breast seroma (2.3% vs 7.4%, P = 0.018), respectively. Risk factors for complications included age (>=65), obesity, American Society of Anesthesiology class (>=3), smoking, hypertension, anxiety, tissue expander (with acellular dermal matrix), and implant-only reconstructions. AB - CONCLUSION: In our study, autologous reconstruction appeared to have a better complication profile than alloplastic reconstruction. Clinicians may potentially use this information to guide preoperative counseling of women considering PM and reconstruction. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001358 PT - Journal Article ID - 10.1097/SAP.0000000000001358 [doi] PP - aheadofprint LG - English EP - 20180223 DP - 2018 Feb 23 EZ - 2018/02/27 06:00 DA - 2018/02/27 06:00 DT - 2018/02/27 06:00 YR - 2018 RD - 20180226 UP - 20180227 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29481482 <594. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29397895 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Wazir U AU - Mokbel K FA - Wazir, Umar FA - Mokbel, Kefah IN - Wazir, Umar. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, UK. IN - Mokbel, Kefah. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, UK. Electronic address: kefahmokbel@hotmail.com. TI - The evolving role of pre-pectoral ADM-assisted implant-based immediate breast reconstruction following skin-sparing mastectomy. SO - American Journal of Surgery. 2018 Feb 02 AS - Am J Surg. 2018 Feb 02 NJ - American journal of surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 3z4, 0370473 IO - Am. J. Surg. CP - United States KW - Breast cancer; Breast implants; Breast reconstruction; Xenografts AB - INTRODUCTION: The increasing use of acellular dermal matrix (ADM) and fat transfer in the context of breast reconstruction, following skin sparing mastectomy (SSM) for therapeutic and risk reducing purposes, combined with the need to eliminate animation deformities, reduce post-operative dysfunctional pain and the risk of capsular contracture, has prompted surgeons to investigate the possibility of placing the mammary implant over the pectoralis major muscle with complete coverage with ADM thus reviving the pre-pectoral approach which was previously abandoned due to high complications rates and poor aesthetics in the pre-ADM era. AB - METHODS: We reviewed the literature regarding this evolving technique of muscle sparing ADM-assisted implant-based immediate breast reconstruction. AB - RESULTS AND CONCLUSIONS: Several authors have recently reported positive early results confirming the potential benefits of eliminating breast animation and reducing postoperative pain, however, most of these reports contain insufficient numbers of patients (<100) and were retrospective in nature with a very short-term follow-up and lack of data regarding objective aesthetic assessment. Prospective data are required for more definitive recommendations. Copyright © 2018. Published by Elsevier Inc. ES - 1879-1883 IL - 0002-9610 DI - S0002-9610(17)31753-1 DO - https://dx.doi.org/10.1016/j.amjsurg.2018.01.021 PT - Journal Article ID - S0002-9610(17)31753-1 [pii] ID - 10.1016/j.amjsurg.2018.01.021 [doi] PP - aheadofprint PH - 2017/12/12 [received] PH - 2018/01/03 [accepted] LG - English EP - 20180202 DP - 2018 Feb 02 DT - 2018/02/06 06:00 YR - 2018 RD - 20180205 UP - 20180205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29397895 <595. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29392359 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Zingaretti N AU - Guarneri GF AU - De Biasio F AU - Shoeib MA AU - Parodi PC AI - Zingaretti, Nicola; ORCID: http://orcid.org/0000-0002-1575-0029 FA - Zingaretti, Nicola FA - Guarneri, Gianni Franco FA - De Biasio, Fabrizio FA - Shoeib, Mohamed A FA - Parodi, Pier Camillo IN - Zingaretti, Nicola. Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, Department of Medical Science, University of Udine, Udine, Italy. zingarettin@gmail.com. IN - Guarneri, Gianni Franco. Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, Department of Medical Science, University of Udine, Udine, Italy. IN - De Biasio, Fabrizio. Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, Department of Medical Science, University of Udine, Udine, Italy. IN - Shoeib, Mohamed A. Department of Plastic Surgery, Sohag Faculty of Medicine, Sohag, Egypt. IN - Parodi, Pier Camillo. Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, Department of Medical Science, University of Udine, Udine, Italy. TI - The Use of Meshed Dermal Autograft in Breast Reconstruction. SO - Aesthetic Plastic Surgery. 2018 Feb 01 AS - Aesthetic Plast Surg. 2018 Feb 01 NJ - Aesthetic plastic surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 2wn, 7701756 IO - Aesthetic Plast Surg CP - United States KW - Acellular dermal matrices; Breast implant; Breast reconstruction; Dermal autograft; Meshed graft AB - The advantages and disadvantages of acellular dermal matrix (ADM) in breast reconstruction have been well documented. ADM is commonly used in breast reconstruction, but it adds cost to the procedure and has been associated with an increased risk of seroma, flap necrosis and infectious complications. A dermal autograft may be a useful alternative to matrices, and it has a lot of advantages: more biocompatible and more likely to be retained as a free graft, low cost, well tolerated, readily available and integrated. This report discusses a new surgical technique that uses an autologous dermis, which was harvested from the controlateral breast in patients having simultaneous breast reduction/mastopexy. Before the insertion, the autologous dermal matrix was meshed at a ratio of 3:1 to increase the graft surface area, to provide additional draining and to improve the engraftment of the autologous dermal matrix. Consequently, the resulting meshed graft allows for the cover of the inferior pole of a larger breast size implant and decreases the complication rate. In our clinic, this method was used on five women; there was one limited necrosis of the mastectomy flaps. The described technique is straightforward and reliable, it adds minimally to the operative time, and it eliminates costs and covers a bigger part of the prosthesis and promises good results. No Level Assigned This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ES - 1432-5241 IL - 0364-216X DO - https://dx.doi.org/10.1007/s00266-018-1090-5 PT - Letter ID - 10.1007/s00266-018-1090-5 [doi] ID - 10.1007/s00266-018-1090-5 [pii] PP - aheadofprint PH - 2018/01/12 [received] PH - 2018/01/20 [accepted] LG - English EP - 20180201 DP - 2018 Feb 01 DT - 2018/02/03 06:00 YR - 2018 RD - 20180202 UP - 20180202 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29392359 <596. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29389701 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Wilson H AU - Varnadore A FA - Wilson, Henry FA - Varnadore, Adam IN - Wilson, Henry. From the Centra Medical Group Plastic Surgery Center, Liberty University College of Medicine, Lynchburg, VA. TI - Evaluation of Modifications to Tissue-Expander Breast Reconstruction, a Quality Improvement Assessment Within a Private Practice. SO - Annals of Plastic Surgery. 2018 Jan 31 AS - Ann Plast Surg. 2018 Jan 31 NJ - Annals of plastic surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - BACKGROUND: As technology advances, surgical practice evolves over time. The author assesses a new approach to implant-based breast reconstruction and the impact of two changes implemented over several years. AB - METHODS: A series of tissue-expander reconstructions performed early in the author's experience were retrospectively compared with a similar number of cases prospectively performed. Demographics, perioperative characteristics, and postoperative outcomes were assessed. AB - RESULTS: Fifty-three patients (87 breasts) were analyzed, 29 treated earlier with one of the early acellular dermal matrices (ADMs) available and 24 current cases using a no-touch operative approach and pliable, perforated ADM. Demographics and perioperative characteristics between the cohorts were comparable. Mean age was 47.6 years, body mass index (BMI) of 25.8 and 18.9% had current or former nicotine use. Immediate reconstruction was performed in 75 (86.2%) breasts. Drains remained in situ 16 +/- 8.9 days, with a significantly lower number of days required in latter patients. At a mean follow-up of 9.6 months, complications included early capsular thickening in 7 (13.2%) patients requiring capsulectomy at the second stage exchange surgery, prosthetic (expander) removal in 3 (3.4%) breasts, significant infection requiring intervention in 3 (5.7%) patients, seroma in 3 (5.7%) patients, 2 (3.8%) cases of wound dehiscence, and 1 (1.9%) case of flap necrosis and hematoma. Incomplete ADM incorporation was observed in 9 (10.3%) breasts. Three reconstructive failures occurred in the early cohort. Patients in the later cohort reported significantly improved BREAST-Q scores (P < 0.005) postoperatively with a high level of satisfaction. AB - CONCLUSIONS: Using a no-touch technique and an ADM designed with functional characteristics advantageous to breast reconstructive surgery appears to have improved patient outcomes. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001320 PT - Journal Article ID - 10.1097/SAP.0000000000001320 [doi] PP - aheadofprint LG - English EP - 20180131 DP - 2018 Jan 31 EZ - 2018/02/02 06:00 DA - 2018/02/02 06:00 DT - 2018/02/02 06:00 YR - 2018 RD - 20180201 UP - 20180202 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29389701 <597. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29369110 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Weinstein B AU - Kumar A AU - Smith P AU - Dayicioglu D FA - Weinstein, Brielle FA - Kumar, Ambuj FA - Smith, Paul FA - Dayicioglu, Deniz IN - Weinstein, Brielle. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL. TI - Moffitt Cancer Center Experience of Tissue Expander Breast Reconstruction: Does Acellular Dermal Matrix Increase Return to the Operating Room?. SO - Annals of Plastic Surgery. 2018 Jan 24 AS - Ann Plast Surg. 2018 Jan 24 NJ - Annals of plastic surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 5vb, 7805336 IO - Ann Plast Surg CP - United States AB - BACKGROUND: Tissue expander and implant remains the most common technique for breast reconstruction. A controversial topic within this method is routine use of acellular dermal matrix (ADM). Acellular dermal matrices have increased risks of infection, seroma, hematoma, skin flap necrosis, and total complications. AB - METHODS: After an institutional review board approval, a retrospective chart review was conducted of 756 tissue expander with implant cases from November 2010 to November 2016 at Moffitt Cancer Center with 2 breast reconstruction surgeons. Patients were grouped in 2 groups: tissue expander alone reconstruction (TE) and tissue expander with ADM (TE + ADM). Complications were defined by return visits to the operating room for irrigation and debridement as well as for subsequent tissue expander placement. AB - RESULTS: There were 703 patients in the TE group and 53 in the TE + ADM group. Patients undergoing TE + ADM reconstruction were 3 times more likely to experience return to operating room compared with patients undergoing TE alone (7.5% vs 2.4%). Patients were significantly more likely to undergo 3 or more subsequent tissue expander placement procedures with TE + ADM (54.7%) compared with TE alone (4.8%) (P < 0.0001). AB - CONCLUSIONS: Although ADM may be appropriate for specific patients, its use in tissue expander breast reconstruction should be judiciously selected, because there is an observed increase in complications needing return to the operating room. ES - 1536-3708 IL - 0148-7043 DO - https://dx.doi.org/10.1097/SAP.0000000000001322 PT - Journal Article ID - 10.1097/SAP.0000000000001322 [doi] PP - aheadofprint LG - English EP - 20180124 DP - 2018 Jan 24 DT - 2018/01/26 06:00 YR - 2018 RD - 20180125 UP - 20180125 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29369110 <598. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29275104 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Cattelani L AU - Polotto S AU - Arcuri MF AU - Pedrazzi G AU - Linguadoca C AU - Bonati E FA - Cattelani, Leonardo FA - Polotto, Susanna FA - Arcuri, Maria Francesca FA - Pedrazzi, Giuseppe FA - Linguadoca, Chiara FA - Bonati, Elena IN - Cattelani, Leonardo. Breast Surgical Unit, University Hospital of Parma, Parma, Italy. Electronic address: cattelanil@hotmail.com. IN - Polotto, Susanna. University Plastic and Reconstructive Unit, University Hospital of Parma, Parma, Italy. IN - Arcuri, Maria Francesca. Breast Surgical Unit, University Hospital of Parma, Parma, Italy. IN - Pedrazzi, Giuseppe. Neuroscience Unit, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy. IN - Linguadoca, Chiara. Pharmacological and Drug Clinical Governance Service, University Hospital of Parma, Parma, Italy. IN - Bonati, Elena. Breast Surgical Unit, University Hospital of Parma, Parma, Italy. TI - One-Step Prepectoral Breast Reconstruction With Dermal Matrix-Covered Implant Compared to Submuscular Implantation: Functional and Cost Evaluation. SO - Clinical Breast Cancer. 2017 Dec 02 AS - Clin Breast Cancer. 2017 Dec 02 NJ - Clinical breast cancer PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 100898731 IO - Clin. Breast Cancer CP - United States KW - Mastectomy; Muscle-sparing; Postoperative pain; Tumor; Upper limb function AB - BACKGROUND: The breast reconstructive subpectoral technique commonly leads to functional consequences. Recently, a new conservative prepectoral breast reconstruction (PPBR) technique was proposed and its surgical safety and aesthetic effectiveness proved. The aim of this prospective nonrandomized study was to compare the functional and economical outcomes of the PPBR procedure versus the subpectoral one. AB - PATIENTS AND METHODS: From February 2015 to September 2016, 86 patients underwent mastectomy with immediate implant-based reconstruction. Thirty-nine patients were assigned to group 1 and received prepectoral acellular dermal matrix-wrapped implant reconstruction. The remaining 45 patients were assigned to group 2 and received a subpectoral implant or tissue expander. We recorded the operating time, length of hospital stay, analgesic consumption, postoperative pain, upper limb function, esthetic satisfaction, and quality of life. Additional surgical procedures for reconstruction completion or contralateral operation for symmetrization were also recorded. AB - RESULTS: Compared to group 2 patients, group 1 patients showed less postoperative pain and faster upper limb functional recovery. Patients in group 1 also recorded a lower analgesic consumption and an earlier return to usual work. Moreover, the muscle-sparing technique improved aesthetic outcomes and largely reduced the need for symmetrization. AB - CONCLUSION: Immediate breast reconstruction by using prepectoral muscle-sparing acellular dermal matrix-wrapped implant resulted in lower pain intensity and significant upper limb functional advantages compared to submuscular implant placement. Furthermore, when considering a series of ascertained benefits, PPBR is also economically advantageous, although future studies should better define its cost-effectiveness. Copyright © 2017 Elsevier Inc. All rights reserved. ES - 1938-0666 IL - 1526-8209 DI - S1526-8209(17)30603-1 DO - https://dx.doi.org/10.1016/j.clbc.2017.11.015 PT - Journal Article ID - S1526-8209(17)30603-1 [pii] ID - 10.1016/j.clbc.2017.11.015 [doi] PP - aheadofprint PH - 2017/09/13 [received] PH - 2017/11/14 [revised] PH - 2017/11/21 [accepted] LG - English EP - 20171202 DP - 2017 Dec 02 EZ - 2017/12/25 06:00 DA - 2017/12/25 06:00 DT - 2017/12/25 06:00 YR - 2017 RD - 20171224 UP - 20171226 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29275104 <599. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29233522 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Mitchell MP AU - Wagner J AU - Butterworth J FA - Mitchell, Melissa P FA - Wagner, Jamie FA - Butterworth, James IN - Mitchell, Melissa P. Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas. Electronic address: mmitchell2@kumc.edu. IN - Wagner, Jamie. Department of Surgery, The University of Kansas Medical Center, Kansas City, Kansas. IN - Butterworth, James. Department of Plastic Surgery, The University of Kansas Medical Center, Kansas City, Kansas. TI - Subcutaneous implant-based breast reconstruction, a modern challenge in postmastectomy radiation planning. SO - Practical Radiation Oncology. 2017 Sep 08 AS - Pract Radiat Oncol. 2017 Sep 08 NJ - Practical radiation oncology PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101558279 IO - Pract Radiat Oncol CP - United States AB - PURPOSE: A growing trend in breast reconstruction has been placement of tissue expanders in the pre pectoral space. This is a change from the practice of placement under the pectoralis major with or without an acellular dermal matrix (ADM) sling. The move toward pre pectoral placement with an ADM wrap has the intent of decreasing post-operative pain and decreasing animation deformities. The cosmesis of pre pectoral reconstructions in the setting of post mastectomy radiation has also appeared improved in our early experience, when compared to submuscular reconstructions. We sought to review the risks and benefits of this technique in the setting of post mastectomy radiation. AB - METHODS AND MATERIALS: Cases of ADM wrapped prepectoral tissue expander breast reconstructions in patients needing postmastectomy radiation therapy were reviewed in a single institution. AB - RESULTS: Thirty patients were treated with ADM wrapped prepectoral tissue expanders. On review of radiation plans, there were patients with anatomical variations, for whom standard dosimetric criteria were not met with partially wide tangent fields. Use of a medial electron field matched to steep photon tangents was not advised due to undercoverage of the tumor bed related to implant placement. Boost treatment was also omitted as a result of concerns regarding the implant location. AB - CONCLUSIONS: While new advances in plastic surgery may improve on cosmetic outcomes for breast cancer patients, increased discussion with radiation oncologists is needed to appropriately select candidates for these procedures. Prospective trials are necessary to ensure that these new techniques do not compromise oncologic outcomes. Copyright © 2017 Elsevier Inc. All rights reserved. ES - 1879-8519 IL - 1879-8500 DI - S1879-8500(17)30258-8 DO - https://dx.doi.org/10.1016/j.prro.2017.09.001 PT - Journal Article ID - S1879-8500(17)30258-8 [pii] ID - 10.1016/j.prro.2017.09.001 [doi] PP - aheadofprint PH - 2017/06/09 [received] PH - 2017/08/10 [revised] PH - 2017/09/05 [accepted] LG - English EP - 20170908 DP - 2017 Sep 08 EZ - 2017/12/14 06:00 DA - 2017/12/14 06:00 DT - 2017/12/14 06:00 YR - 2017 RD - 20171213 UP - 20171214 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29233522 <600. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 29202515 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Zarei F AU - Daraee H FA - Zarei, Farshad FA - Daraee, Hadis IN - Zarei, Farshad. Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran. IN - Daraee, Hadis. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical sciences, Tehran, Iran. TI - Recent Progresses in Breast Reconstruction: Stem Cells, Biomaterials, and Growth Factors. SO - Drug Research. 2017 Dec 04 AS - Drug Res (Stuttg). 2017 Dec 04 NJ - Drug research PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 101602406 IO - Drug Res (Stuttg) CP - Germany AB - Breast cancer is one of the most deadly tumors in women, and new procedures for post- surgical breast reconstruction have been developed which includes autologous stromal vascular fraction (SVF), platelet-derived growth factors, biomaterials and various stem cells. Adipose derived-stem cells (ASCs) has been reported to be one of the most widely used stem cell for breast reconstruction because of their ability to form new functional adipose tissue and vessels and in combination with stromal vascular fraction has been also reported efficient for breast reconstruction. Biomaterials include acellular dermal matrix, bone substitutes, and injectable have also been reported to be applicable for several clinical applications, including breast reconstruction surgery. Nevertheless, further studies are needed to explicitly define methodological procedures and to confirm the safety of all theses procedures during post-surgical breast reconstruction. The purpose of this mini-review is to summarize various recent and old applications of stem cells, biomaterials as well as growth factors in breast reconstruction. Copyright © Georg Thieme Verlag KG Stuttgart . New York. CI - Conflict of Interest: The authors have no conflict of interest in any terms or by any means during the study. All the funds were provided by research center and disbursed accordingly. ES - 2194-9387 IL - 2194-9379 DO - https://dx.doi.org/10.1055/s-0043-122490 PT - Journal Article ID - 10.1055/s-0043-122490 [doi] PP - aheadofprint LG - English EP - 20171204 DP - 2017 Dec 04 EZ - 2017/12/05 06:00 DA - 2017/12/05 06:00 DT - 2017/12/05 06:00 YR - 2017 RD - 20171204 UP - 20171205 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=29202515 <601. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27893634 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Pittman TA AU - Fan KL AU - Knapp A AU - Frantz S AU - Spear SL FA - Pittman, Troy A FA - Fan, Kenneth L FA - Knapp, Andrew FA - Frantz, Shelby FA - Spear, Scott L IN - Pittman, Troy A. 1Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, D.C. 2Georgetown University School of Medicine, Washington, D.C. 3Private Practice, Washington, D.C. TI - Comparison of Different Acellular Dermal Matrix (ADM) in Breast Reconstruction: The 50/50 Study. SO - Plastic & Reconstructive Surgery. 2016 Nov 21 AS - Plast Reconstr Surg. 2016 Nov 21 NJ - Plastic and reconstructive surgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - 1306050 IO - Plast. Reconstr. Surg. CP - United States AB - BACKGROUND: Acellular Dermal Matrix (ADM) has enjoyed extensive use in primary and secondary alloplastic breast aesthetic and reconstructive surgery. The objective of this study is to examine clinical outcomes between available ADM: DermACELL(LifeNet Health, Virginia Beach, VA) and AlloDerm RTU (LifeCell, Branchburg, New Jersey). AB - METHODS: A retrospective chart review was performed on 58 consecutive patients (100 breasts) reconstructed with either DermACELL(n=30 patients; 50 breasts) or AlloDerm RTU (n=28 patients; 50 breasts). The mastectomies were performed by three different breast surgeons. All reconstructions were performed by the same Plastic surgeon (TAP). Statistical analysis was performed by Fisher's exact test. AB - RESULTS: The average age, BMI, percent having neo-adjuvant/adjuvant chemotherapy or breast irradiation, and numbers of therapeutic and prophylactic mastectomies between the two groups was not statistically significant (p<0.05). Complications in both cohorts of patients were clinically recorded for 90 days post immediate reconstruction. When comparing outcomes, patients in the DermACELL group had significantly less incidence of 'red breast' (0% vs 26%, p=0.0001) and fewer days before drain removal(15.8 vs 20.6, p=0.017). No significant difference was seen in terms of seroma, hematoma, delayed healing, infection, flap necrosis, and explantation. AB - CONCLUSIONS: Patients reconstructed with DermACELL as compared to AlloDerm RTU have significantly decreased number of days to drain removal and 'red breast' syndrome and equivalent rates of other complications including seroma, infection, flap necrosis and explantation. ES - 1529-4242 IL - 0032-1052 PT - Journal Article ID - 10.1097/PRS.0000000000003048 [doi] PP - aheadofprint LG - English EP - 20161121 DP - 2016 Nov 21 EZ - 2016/11/29 06:00 DA - 2016/11/29 06:00 DT - 2016/11/29 06:00 YR - 2016 RD - 20161129 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27893634 <602. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 27770576 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Momeni A AU - Kanchwala SK FA - Momeni, Arash FA - Kanchwala, Suhail K IN - Momeni, Arash. Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Palo Alto, California. amomeni@stanford.edu. IN - Kanchwala, Suhail K. Division of Plastic Surgery, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania. TI - Improved pocket control in immediate microsurgical breast reconstruction with simultaneous implant placement through the use of mesh. SO - Microsurgery. 2016 Oct 22 AS - Microsurgery. 2016 Oct 22 NJ - Microsurgery PI - Journal available in: Print-Electronic PI - Citation processed from: Internet JC - mis, 8309230 IO - Microsurgery CP - United States KW - breast reconstruction; flap; implant; microsurgery; plastic surgery AB - BACKGROUND: Autologous breast reconstruction is associated with long-term patient satisfaction that is superior to implant-based approaches. Occasionally, however, patients who desire autologous reconstruction present with inadequate donor-site volume. A hybrid approach, combining free flap reconstruction with simultaneous implant placement, is a solution. We present our experience with the use of mesh for improved pocket control using this reconstructive modality. AB - METHODS: A retrospective analysis of a prospectively maintained database of patients undergoing autologous breast reconstruction was performed. Patients who underwent bilateral immediate breast reconstruction with free microsurgical abdominal tissue transfer with simultaneous implant placement were included for analysis. AB - RESULTS: A total of 19 patients (38 breasts) with a mean age of 42.7 years (range, 31-57 years) and mean BMI of 26.3 (range, 23.6-30.8) were included in the study. No flap loss or implant-related complications were encountered during a mean follow-up of 14.2 months. The most common implant volume was 150 cc (N=15; [78.9%]). No patient requested an implant change due to malposition or insufficient volume. Secondary fat grafting was performed in 5 patients (26.3%), 4 of which had undergone adjuvant radiotherapy. Three cases of red breast syndrome were observed following acellular dermal matrix placement. This prompted a transition to using polyglactin mesh thereafter without any untoward sequelae. AB - CONCLUSIONS: Abdominal flap transfer with simultaneous implant placement is a safe reconstructive option in select patients. Improved implant pocket control is achieved through the use of mesh, thus, minimizing problems related to implant malposition. Adjuvant radiotherapy does not appear to put the reconstruction at risk with the occasional flap volume loss being easily remedied by secondary fat grafting. Copyright © 2016 Wiley Periodicals, Inc. ES - 1098-2752 IL - 0738-1085 DO - https://dx.doi.org/10.1002/micr.30123 PT - Journal Article ID - 10.1002/micr.30123 [doi] PP - aheadofprint PH - 2016/08/18 [received] PH - 2016/09/17 [revised] PH - 2016/09/30 [accepted] LG - English EP - 20161022 DP - 2016 Oct 22 EZ - 2016/10/23 06:00 DA - 2016/10/23 06:00 DT - 2016/10/23 06:00 YR - 2016 RD - 20161023 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=27770576 <603. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 26635446 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Ng CE AU - Pieri A AU - Fasih T FA - Ng, Cho Ee FA - Pieri, Andrew FA - Fasih, Tarannum IN - Ng, Cho Ee. Surgical Department, Queen Elizabeth Hospital, Gateshead, NE9 6SX UK. IN - Pieri, Andrew. Surgical Department, Queen Elizabeth Hospital, Gateshead, NE9 6SX UK. IN - Fasih, Tarannum. Surgical Department, Queen Elizabeth Hospital, Gateshead, NE9 6SX UK. TI - Porcine acellular dermis-based breast reconstruction: complications and outcomes following adjuvant radiotherapy. SO - European Journal of Plastic Surgery. 38(6):459-462, 2015 AS - EUR. J. PLAST. SURG.. 38(6):459-462, 2015 NJ - European journal of plastic surgery VO - 38 IP - 6 PG - 459-462 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 8700891 IO - Eur J Plast Surg CP - Germany KW - Acellular dermal matrix; Breast reconstruction; Radiotherapy; StratticeTM AB - BACKGROUND: Acellular dermal matrices (ADM) such as Strattice^TM are increasingly used in UK during implant-based reconstruction. However, there are mixed opinions regarding the compatibility of radiotherapy treatment in pre- and post-reconstructed breasts. The aims of this study are to audit the rates of radiation induced complications in patients who underwent breast reconstruction using Strattice^TM and establish whether there is an association between timing of radiotherapy and complication rates. AB - METHODS: Retrospective data collection was performed for all patients who underwent skin-sparing mastectomy and immediate or delayed Strattice^TM-based reconstruction, and received pre- or post-reconstruction radiotherapy from July 2010 to November 2014. AB - RESULTS: The age ranged from 33 to 78 years (mean age 51+/-10.6) with a mean follow-up time of 21 months. There were 25 Strattice^TM-based reconstructions performed. Sixteen had delayed reconstruction, and 9 had skin-sparing mastectomy and immediate reconstruction. There were 4 (16 %) abandoned procedures due to inability to stretch the mastectomy flap secondary to poor skin compliance. Two women (8 %) presented 4 and 9 months later with wound breakdown. One case (4 %) developed severe capsular contracture following radiotherapy post-reconstruction and 1 case (4 %) of implant rupture. There were no episodes of extrusion or implant infection. Overall complication rates were 32 %. The majority (75 %) of complications occurred in breasts reconstructed post-radiotherapy; however, this is not significant when analysed using chi-square (p=0.43). AB - CONCLUSIONS: Our evidence suggests that there is no difference in complication rates in pre- and post-radiation individuals; this would suggest that implant-based reconstruction using Strattice^TM should not be an absolute contraindication in pre- or post-radiotherapy patients. However, when planning these procedures, it is paramount that the increased risks are emphasised to patients in order to better manage patient expectation in cases where complications arise. Level of Evidence: Level III, risk / prognostic study. IS - 0930-343X IL - 0930-343X PT - Journal Article ID - 10.1007/s00238-015-1130-1 [doi] ID - 1130 [pii] ID - PMC4656711 [pmc] PP - ppublish PH - 2015/02/22 [received] PH - 2015/07/01 [accepted] LG - English EP - 20150802 DP - 2015 EZ - 2015/12/05 06:00 DA - 2015/12/05 06:00 DT - 2015/12/05 06:00 YR - 2015 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=26635446 <604. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 25221385 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Bullocks JM FA - Bullocks, Jamal M IN - Bullocks, Jamal M. Plastic Surgery Division, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA. TI - DermACELL: a novel and biocompatible acellular dermal matrix in tissue expander and implant-based breast reconstruction. SO - European Journal of Plastic Surgery. 37(10):529-538, 2014 AS - EUR. J. PLAST. SURG.. 37(10):529-538, 2014 NJ - European journal of plastic surgery VO - 37 IP - 10 PG - 529-538 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 8700891 IO - Eur J Plast Surg CP - Germany KW - Acellular dermal matrix; Breast; Tissue expanders; Two-stage reconstruction AB - BACKGROUND: Acellular dermal matrices present a new alternative to supporting expanders and implants for breast reconstruction in breast cancer patients following mastectomy. However, some studies have suggested that acellular dermal matrix may increase the complication rates in certain clinical settings. DermACELL acellular dermal matrix offers advanced processing in order to attempt to decrease bio-intolerance and complications. AB - METHODS: Ten consecutive patients that presented for breast reconstruction and were candidates for tissue expanders underwent the procedure with the use of an acellular dermal matrix. The patients underwent postoperative expansion/adjuvant cancer therapy, then tissue expander exchange for permanent silicone breast prostheses. Patients were followed through the postoperative course to assess complication outcomes. Histologic evaluation of host integration into the dermal matrix was also assessed. AB - RESULTS: Of the ten patients, eight completed reconstruction while two patients failed reconstruction. The failures were related to chronic seromas and infection. Histology analysis confirms rapid integration of mesenchymal cells into the matrix compared to other acellular dermal matrices. AB - CONCLUSIONS: Based on our observations, DermACELL is an appropriate adjunct to reconstruction with expanders. Histological analysis of vascularization and recellularization support the ready incorporation of DermACELL into host tissue. Level of Evidence: Level IV, therapeutic study. IS - 0930-343X IL - 0930-343X PT - Journal Article ID - 10.1007/s00238-014-0995-8 [doi] ID - 995 [pii] ID - PMC4161921 [pmc] PP - ppublish PH - 2014/04/28 [received] PH - 2014/07/12 [accepted] LG - English EP - 20140731 DP - 2014 EZ - 2014/09/16 06:00 DA - 2014/09/16 06:00 DT - 2014/09/16 06:00 YR - 2014 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=25221385 <605. > VN - Ovid Technologies DB - Ovid MEDLINE(R) UI - 23002328 VI - 1 RO - From MEDLINE, a database of the U.S. National Library of Medicine. ST - Publisher AU - Mofid MM AU - Meininger MS AU - Lacey MS FA - Mofid, Mehrdad Mark FA - Meininger, Michael S FA - Lacey, Martin S IN - Mofid, Mehrdad Mark. Division of Plastic Surgery, University of California San Diego, 4150 Regents Park Row Suite #300, La Jolla, CA 92037 USA. TI - Veritas bovine pericardium for immediate breast reconstruction: a xenograft alternative to acellular dermal matrix products. SO - European Journal of Plastic Surgery. 35(10):717-722, 2012 Oct AS - EUR. J. PLAST. SURG.. 35(10):717-722, 2012 Oct NJ - European journal of plastic surgery VO - 35 IP - 10 PG - 717-722 PI - Journal available in: Print-Electronic PI - Citation processed from: Print JC - 8700891 IO - Eur J Plast Surg CP - Germany AB - BACKGROUND: The technical advantages in utilizing human acellular dermal matrix (ADM) products as pectoral extenders in immediate breast reconstruction with tissue expanders or implants are well documented in the medical literature. In this study, the authors examine a commonly used biologic xenograft product that has not yet been described in the medical literature for use in immediate breast reconstruction to determine whether a lower overall complication rate is identified compared to published data on ADM products. METHODS: A retrospective multicenter medical record review of data on 54 subjects in 93 tissue expander/implant-based, consecutive, immediate breast reconstructions from three surgeons at different institutions was performed in which Veritas bovine pericardium was used as the biologic graft material for the pectoral extender. RESULTS: Over a 24-month period with an average of 11-month follow-up, complication rates using Veritas in breast reconstruction for seroma formation (7.5 %), marginal skin flap necrosis (5.4 %) infection (6.5 %), and capsular contracture (0 %) were found to compare equally or favorably with statistically significant lower overall complications relative to one comparison study and lower rates of marginal skin flap necrosis relative to two comparison studies based upon previously published data from multisurgeon studies using ADM products. CONCLUSIONS: Overall complications were found to be lower with Veritas than ADM products in comparable multisurgeon studies, though this was found to be statistically significant in only one comparison study. Level of Evidence: Level II, theraputic study. IS - 0930-343X IL - 0930-343X PT - Journal Article ID - 10.1007/s00238-012-0736-9 [doi] ID - 736 [pii] ID - PMC3443340 [pmc] PP - ppublish PH - 2012/04/22 [received] PH - 2012/05/22 [accepted] LG - English EP - 20120617 DP - 2012 Oct EZ - 2012/09/25 06:00 DA - 2012/09/25 06:00 DT - 2012/09/25 06:00 YR - 2012 RD - 20170220 UP - 20171128 XL - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medp&AN=23002328