Date: 11 October 2024

Dataset Title: Experimental & numerical investigations of ultra-high-speed dynamics of optically induced droplet cavitation in soft materials

Dataset Creators: Bachir A. Abeid, Mario L. Fabiilli, Mitra Aliabouzar, Jon B. Estrada

Dataset Contact: Bachir A. Abeid babeid@umich.edu

Funding: NIH Grant R01HL139656 (MLF), startup funding from University of Michigan - Department of Mechanical Engineering (JBE),funding for experimental platform development from NSF grant CMMI2232426 (JBE)

Key Points:
- We examined effects such as droplet size and PFC core on bubble dynamics and material viscoelastic properties within three different hydrogels, each of different concentrations.
- Gelatin hydrogels reveal concentration-dependent impacts on bubble expansion and material elasticity. 
- Embedding PFC droplets in gelatin increases internal pressure, resulting in higher equilibrium radius and continuous bubble growth during quasi-static evolution. 
- Similar trends are observed in fibrin and polyacrylamide matrices, with differences in bubble behavior attributed to matrix properties and droplet presence. 
- Droplet size exhibits minimal impact on bubble expansion during inertial dynamics but influences quasi-static evolution, with larger droplets leading to continuous growth beyond 60 seconds. 
- The core composition of PFC droplets significantly affects bubble behavior, with higher boiling point droplets exhibiting higher maximum expansion and faster quasi-static dissolution rates. 

Research Overview:
Perfluorocarbon (PFC) droplets represent a novel class of phase-shift contrast agent with a promise in applications in biomedical and bioengineering fields. PFC droplets undergo a fast liquid-gas transition upon exposure to acoustic or optical triggering, 
offering a potential adaptable and versatile tool as contrast agent in diagnostics imaging and localized drug delivery vehicles in therapeutics systems. In this paper, we utilize advanced imaging techniques to investigate ultra-high-speed inertial dynamics and
rectified quasi-static (low-speed) diffusion evolution of optically induced PFC droplet vaporization. The study sheds light on the intricate interplay between droplet characteristics, matrix properties, and multi-timescale bubble dynamics, offering valuable insights into their behavior within biomimetic hydrogels.

Methodology:
The data are the output of the microcavitation experimental setup, which generates and records single, sub-millimeter laser-induced cavitation (LIC) bubble events at 1 million fps in soft hydrogels and materials using a combination of single 4 ns pulses of a user-adjustable, 
frequencydoubled Q-switched 532 nm Nd:YAG laser (Continuum Minilite II, San Jose, CA), an ultra-high-speed imaging camera (HPV-X2; Shimadzu, Kyoto, Japan) and a low-speed imaging camera (FLIR).

Instrument and/or Software specifications: Videos where processed using Matlab R2023a

Files contained here:
Matlab file (.mat) include all processed experiments.  

Three folders contain raw AVI videos. 
The videos names end in time(HH_MM_SS). The prefixes are described below. 

AVI24_Gelatin
- Geletin_05w_w : 05% Native Gelatin
- Geletin_10w_w : 10% Native Gelatin
- Geletin_15w_w : 15% Native Gelatin
- pfh_12_Gel_10w_w : 10% Gelatin with 12 um diameter PFH droplets
- pfo_12_Gel_10w_w : 10% Gelatin with 12 um diameter PF0 droplets
- pfp_3_Gel_10w_w : 10% Gelatin with 3 um diameter PFP droplets
- pfp_6_Gel_10w_w : 10% Gelatin with 6 um diameter PFP droplets
- pfp_Gelat_05w_w : 05% Gelatin with 12 um diameter PFP droplets
- pfp_Gelat_10w_w : 10% Gelatin with 12 um diameter PFP droplets
- pfp_Gelat_15w_w : 15% Gelatin with 12 um diameter PFP droplets 

AVI24_Fibrin
- Fib_02_10X : 0.2% Native Fibrin
- Fib_02_10X_pfp : 0.2% Fibrin with 6 um diameter PFP droplets
- Fib_01_10X : 1% Native Fibrin
- Fib_01_10X_pfp : 1% Fibrin with 6 um diameter PFP droplets
- Fib_04_10X : 4% Native Fibrin
- Fib_04_10X_pfp : 4% Fibrin with 6 um diameter PFP droplets

AVI24_PA
PA_B_S1 : 3/0.1 Native Polyacrylamide (Acry/Bis %)
PA_B_pfp_S1 : 3/0.1 Polyacrylamide (Acry/Bis %) with 6 um diameter PFP droplets
PA_D_S1 : 5/0.15 Native Polyacrylamide (Acry/Bis %)
PA_D_pfp_S1 : 5/0.15 Polyacrylamide (Acry/Bis %) with 6 um diameter PFP droplets
PA_E_S1 : 5/0.3 Native Polyacrylamide (Acry/Bis %)
PA_E_pfp_S1 : 5/0.3 Polyacrylamide (Acry/Bis %) with 6 um diameter PFP droplets
PA_F_S1 : 8/0.26 Native Polyacrylamide (Acry/Bis %)
PA_F_pfp_S1 : 8/0.26 Polyacrylamide (Acry/Bis %) with 6 um diameter PFP droplets


Each files has the following variables: 


Roft = Bubble radius during inertial dynamics in (m) 
t = time during inertial dynamics in (s)
t_norm = Normalized time 
R_norm = Normalized Radius 
t0 = maximum expansion time (s)
R0 = Maximum expansion (m)
Req = equilibrium radius during inertial dynamics in (m) 
Related publication(s):
Abeid, Bachir A, et al. (2024). Experimental and numerical investigations of ultra-high-speed dynamics of optically induced droplet cavitation in soft materials  

Use and Access:
This data set is made available under a Creative Commons Public Domain license (CC0 1.0).

To Cite Data:
 Bachir A. Abeid, Mario L. Fabiilli, Mitra Aliabouzar, Jon B. Estrada. (2024). Experimental and numerical investigations of ultra-high-speed dynamics of optically induced droplet cavitation in soft materials [Data set]. University of Michigan - Deep Blue. https://doi.org/10.7302/yb8v-pp71