1142 Records downloaded  - Tue Jul 02 14:06:57 UTC 2019


RECORD 1
TITLE
  Morbidity During Adult Congenital Heart Surgery Admissions
AUTHOR NAMES
  Setton M.; He W.; Benavidez O.J.
AUTHOR ADDRESSES
  (Setton M.; He W.; Benavidez O.J., ojbenavidez@mgh.harvard.edu) Division of 
Pediatric-Congenital Cardiology, Department of Pediatric, MassGeneral 
Hospital for Children, Massachusetts General Hospital, Harvard Medical 
School, 175 Cambridge Street, Suite 510, Boston, United States.
CORRESPONDENCE ADDRESS
  O.J. Benavidez, Division of Pediatric-Congenital Cardiology, Department of 
Pediatric, MassGeneral Hospital for Children, Massachusetts General 
Hospital, Harvard Medical School, 175 Cambridge Street, Suite 510, Boston, 
United States. Email: ojbenavidez@mgh.harvard.edu
AiP/IP ENTRY DATE
  2019-05-31
FULL RECORD ENTRY DATE
  2019-06-14
SOURCE
  Pediatric Cardiology (2019) 40:5 (987-993). Date of Publication: 15 Jun 2019
VOLUME
  40
ISSUE
  5
FIRST PAGE
  987
LAST PAGE
  993
DATE OF PUBLICATION
  15 Jun 2019
ISSN
  1432-1971 (electronic)
  0172-0643
BOOK PUBLISHER
  Springer New York LLC, barbara.b.bertram@gsk.com
ABSTRACT
  The frequency of complications during Adult Congenital Heart Disease (ACHD) 
surgery admissions and their association to patient outcome is not well 
known. Our study objectives are to (1) define the frequency of complications 
during ACHD surgery admissions, (2) identify their risk factors, and (3) 
explore their association with death and resource use. We identified ACHD 
surgery admissions ages 18 to 49 during the years 2005–2009 from the 
Nationwide Inpatient Sample database. Complications were defined according 
to the Society of Thoracic Surgeons Short List of Complications for 
congenital heart surgery. We identified 16,841 ACHD surgery admissions, of 
which 46.9% had at least one complication. Cardiac (19.4%), respiratory 
(18.2%), infectious (14.1%), and acute kidney injury (6.8%) were the most 
common. Admissions with a complication had a longer length of stay (10 days 
vs. 5 days; p < 0.001), increased charges ($139,522 vs. $84,672; p < 0.001), 
and higher mortality (4.6% vs. 0.9%; p < 0.001). Adjusted risk factors for 
complications included non-White race (AOR 1.17, p = 0.003), government 
insurance AOR 1.39, high surgical complexity RACHS-1 category 3 + AOR 1.81, 
non-elective admission OR 2.18, chronic kidney disease AOR 2.79, chronic 
liver disease AOR 2.47, and CHF AOR 1.40; all p < 0.001. Complications were 
independently associated with death AOR 2.49, p < 0.001. Complications occur 
frequently during ACHD surgery admissions and are associated with increased 
resource use and are a risk factor for death. Identification of preventable 
morbidity may improve the outcomes of these complex patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  congenital heart disease (surgery); heart surgery; hospital admission; morbidity; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication); adult; aortic coarctation (surgery); aortic regurgitation (surgery); aortic valve stenosis (surgery); article; bleeding (complication); chronic kidney failure; chronic liver disease; chylothorax (complication); controlled study; convulsion (complication); death; diaphragm paralysis (complication); endocarditis (complication); Fallot tetralogy (surgery); female; health care utilization; heart arrest (complication); heart arrhythmia (complication); heart atrium septum defect (surgery); heart disease (complication); heart failure (complication); heart ventricle septum defect (surgery); hospital charge; human; infection (complication); length of stay; lung insufficiency (complication); major clinical study; male; mortality; necrotizing enterocolitis (complication); nerve injury (complication); neurologic disease (complication); pericarditis (complication); pleura effusion (complication); pneumonia (complication); pneumothorax (complication); postoperative complication (complication); public health insurance; pulmonary artery malformation (surgery); pulmonary hypertension (complication); pulmonary vein obstruction (complication); race; respiratory tract disease (complication); risk factor; sepsis (complication); spinal cord injury (complication); surgical risk; tracheostomy; vein occlusion (complication); vocal cord paralysis (complication); wound dehiscence (complication); wound infection (complication); 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30976885 (http://www.ncbi.nlm.nih.gov/pubmed/30976885)
PUI
  L627801474
DOI
  10.1007/s00246-019-02103-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00246-019-02103-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14321971&id=doi:10.1007%2Fs00246-019-02103-5&atitle=Morbidity+During+Adult+Congenital+Heart+Surgery+Admissions&stitle=Pediatr.+Cardiol.&title=Pediatric+Cardiology&volume=40&issue=5&spage=987&epage=993&aulast=Setton&aufirst=Matan&auinit=M.&aufull=Setton+M.&coden=PECAD&isbn=&pages=987-993&date=2019&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 2
TITLE
  The Characteristics and Cost of Le Fort Fractures: A Review of 519 Cases 
From a Nationwide Sample
AUTHOR NAMES
  Lee K.C.; Chuang S.-K.; Eisig S.B.
AUTHOR ADDRESSES
  (Lee K.C., kcl2136@cumc.columbia.edu) Resident, Section of Hospital 
Dentistry, Division of Oral and Maxillofacial Surgery, 
NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia 
University College of Dental Medicine, New York, United States.
(Chuang S.-K.) Clinical Professor, Department of Oral and Maxillofacial 
Surgery, University of Pennsylvania, Philadelphia, PA; Private Practice, 
Brockton Oral and Maxillofacial Surgery Inc., Department of Oral and 
Maxillofacial Surgery, Good Samaritan Medical Center, Brockton, United 
States.
(Eisig S.B.) Chairman and George Guttman Professor of Craniofacial Surgery, 
Section of Hospital Dentistry, Division of Oral and Maxillofacial Surgery, 
NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia 
University College of Dental Medicine, New York, United States.
CORRESPONDENCE ADDRESS
  K.C. Lee, 630 West 168th Street, New York, United States. Email: 
kcl2136@cumc.columbia.edu
AiP/IP ENTRY DATE
  2019-03-29
FULL RECORD ENTRY DATE
  2019-05-23
SOURCE
  Journal of Oral and Maxillofacial Surgery (2019) 77:6 (1218-1226). Date of 
Publication: 1 Jun 2019
VOLUME
  77
ISSUE
  6
FIRST PAGE
  1218
LAST PAGE
  1226
DATE OF PUBLICATION
  1 Jun 2019
ISSN
  1531-5053 (electronic)
  0278-2391
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Purpose: The aims were to report the characteristics of Le Fort fractures 
and to quantify the associated hospital costs. Materials and Methods: From 
October 2015 to December 2016, the National Inpatient Sample was searched 
for patients admitted with a primary diagnosis of a Le Fort fracture. 
Predictor variables were drawn from demographic, admission, and injury 
characteristics. The outcome variable was hospital cost. Summary statistics 
were calculated and compared among Le Fort patterns. Univariate comparisons 
and multivariate regression analyses were conducted to determine predictors 
associated with cost. Results: A total of 519 patients were identified in 
this cohort. Associated injuries included skull fractures (28%), 
intracranial hemorrhage (13%), cervical spine injury (9.8%), and concussion 
(9.1%). Seventy-three percent of patients received open reduction and 
internal fixation (ORIF) for their facial fractures during their admission, 
13% received a tracheostomy, and 10% were mechanically ventilated for at 
least 1 day. The ventilation (P < .01) and tracheostomy (P < .01) rates 
increased with Le Fort complexity, as did length of stay (LOS; P < .01), 
costs (P < .01), and charges (P < .01). The mean costs of treating Le Fort 
I, II, and III fractures were $25,836, $28,415, and $47,333, respectively. 
Increased cost was independently associated with younger age, male gender, 
African-American ethnicity, Le Fort II and III patterns, motor vehicle 
accident etiology, mechanical ventilation requirement, tracheostomy, ORIF, 
transfer to an outside facility, and increased LOS. Conclusions: The 
prevalence of head injuries and the need for respiratory support 
substantially increased with Le Fort complexity. Hospital costs were not 
markedly influenced by the diagnosis and management of associated injuries. 
Instead, costs were predominantly driven by fracture complexity and the need 
for necessary procedures, such as ORIF, tracheostomy, and mechanical 
ventilation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hospital cost; le fort fracture (diagnosis, disease management, surgery); Le Fort I osteotomy; maxilla fracture (diagnosis, disease management, surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; brain hemorrhage (surgery); cervical spine injury (surgery); child; cohort analysis; comparative study; concussion (surgery); controlled study; demography; ethnic difference; face fracture (surgery); female; health insurance; hospital admission; human; ICD-10-CM; length of stay; major clinical study; male; open reduction (procedure); osteosynthesis; retrospective study; skull fracture; tracheostomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Public Health, Social Medicine and Epidemiology (17)
  Gerontology and Geriatrics (20)
  Health Policy, Economics and Management (36)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30853420 (http://www.ncbi.nlm.nih.gov/pubmed/30853420)
PUI
  L2001730941
DOI
  10.1016/j.joms.2019.01.060
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.joms.2019.01.060
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15315053&id=doi:10.1016%2Fj.joms.2019.01.060&atitle=The+Characteristics+and+Cost+of+Le+Fort+Fractures%3A+A+Review+of+519+Cases+From+a+Nationwide+Sample&stitle=J.+Oral+Maxillofac.+Surg.&title=Journal+of+Oral+and+Maxillofacial+Surgery&volume=77&issue=6&spage=1218&epage=1226&aulast=Lee&aufirst=Kevin+C.&auinit=K.C.&aufull=Lee+K.C.&coden=JOMSD&isbn=&pages=1218-1226&date=2019&auinit1=K&auinitm=C
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 3
TITLE
  Novel approach using ultrasonic bone curettage and transoral robotic surgery 
for en bloc resection of cervical spine chordoma: Case report
AUTHOR NAMES
  Petrov D.; Spadola M.; Berger C.; Glauser G.; Mahmoud A.F.; O’Malley B.; Malhotra N.R.
AUTHOR ADDRESSES
  (Petrov D.; Spadola M.; Berger C.; Glauser G.; Malhotra N.R., 
neil.malhotra@uphs.upenn.edu) University of Pennsylvania Perelman, School of 
Medicine, Department of Neurological Surgery, United States.
(Mahmoud A.F.; O’Malley B.) University of Pennsylvania Perelman, School of 
Medicine, Department of Otorhinolaryngology, United States.
(Malhotra N.R., neil.malhotra@uphs.upenn.edu) Translational Spine Research 
Lab, University of Pennsylvania, Philadelphia, United States.
CORRESPONDENCE ADDRESS
  N.R. Malhotra, University of Pennsylvania Perelman, School of Medicine, 
Department of Neurological Surgery, United States. Email: 
neil.malhotra@uphs.upenn.edu
AiP/IP ENTRY DATE
  2019-06-07
FULL RECORD ENTRY DATE
  2019-06-11
SOURCE
  Journal of Neurosurgery: Spine (2019) 30:6 (788-793). Date of Publication: 1 
Jun 2019
VOLUME
  30
ISSUE
  6
FIRST PAGE
  788
LAST PAGE
  793
DATE OF PUBLICATION
  1 Jun 2019
ISSN
  1547-5646 (electronic)
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons
ABSTRACT
  Chordomas are rare, locally aggressive neoplasms that develop from remnants 
of the notochord. The typical approach to chordomas of the clivus and axial 
cervical spine often limits successful en bloc resection. In this case 
report, authors describe the first-documented transoral approach using both 
transoral robotic surgery (TORS) for exposure and the Sonopet bone scalpel 
under navigational guidance to achieve en bloc resection of a cervical 
chordoma. This 27-year-old man had no significant past medical history 
(Charlson Comorbidity Index 0). During a trauma workup following a motor 
vehicle collision, a CT of the patient’s cervical spine demonstrated an 
incidental 2.2-cm lesion situated along the posterior aspect of the C2 
vertebral body. Postoperative imaging showed successful en bloc resection 
with adequate placement of hardware, and the pathology report demonstrated 
negative resection margins. The patient tolerated the procedure well, and 
because of the successful en bloc resection, radiation has been deferred. At 
7 months postoperatively, the patient returned to work in New York City. 
Contrasted MRI at 15 months postoperatively showed the patient to be disease 
free. This approach offers a promising way forward in the treatment of these 
complex tumors.
EMTREE DRUG INDEX TERMS
  antibiotic agent (intravenous drug administration); proton; titanium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine chordoma (diagnosis, radiotherapy, surgery); chordoma (diagnosis, radiotherapy, surgery); curettage; en bloc resection; robot assisted surgery; spine tumor (diagnosis, radiotherapy, surgery); transoral robotic surgery; ultrasonic bone curettage; 
EMTREE MEDICAL INDEX TERMS
  adult; article; assessment of humans; cancer diagnosis; cancer radiotherapy; case report; cervical spine; charlson comorbidity index 0; clinical article; dissector; human; laminectomy; male; medical device complication; needle biopsy; nuclear magnetic resonance imaging; osteotomy; postoperative period; proton therapy; surgical margin; surgical navigation system; tracheostomy; traffic accident; vertebra body; wound dehiscence; 
CAS REGISTRY NUMBERS
  proton (12408-02-5, 12586-59-3)
  titanium (7440-32-6)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L2002056194
DOI
  10.3171/2018.11.SPINE181162
FULL TEXT LINK
  http://dx.doi.org/10.3171/2018.11.SPINE181162
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475646&id=doi:10.3171%2F2018.11.SPINE181162&atitle=Novel+approach+using+ultrasonic+bone+curettage+and+transoral+robotic+surgery+for+en+bloc+resection+of+cervical+spine+chordoma%3A+Case+report&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=30&issue=6&spage=788&epage=793&aulast=Petrov&aufirst=Dmitriy&auinit=D.&aufull=Petrov+D.&coden=&isbn=&pages=788-793&date=2019&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 4
TITLE
  Tracheostomy in trauma patients with rib fractures
AUTHOR NAMES
  Fokin A.; Wycech J.; Chin Shue K.; Stalder R.; Lozada J.; Puente I.
AUTHOR ADDRESSES
  (Fokin A., Alexander.Fokin@tenethealth.com; Wycech J.; Puente I.) Division 
of Trauma and Critical Care Services, Delray Medical Center, 5352 Linton 
Boulevard, Delray Beach, United States.
(Wycech J.; Lozada J.; Puente I.) Division of Trauma and Critical Care 
Services, Broward Health Medical Center, 1600 S Andrews Ave, Fort 
Lauderdale, United States.
(Chin Shue K.; Puente I.) Charles E. Schmidt College of Medicine, Department 
of Surgery, Florida Atlantic University, 777 Glades Rd, Boca Raton, United 
States.
(Stalder R.) Wake Forest University, 1834 Wake Forest Rd, Winston-Salem, 
United States.
(Puente I.) Herbert Wertheim College of Medicine, Department of Surgery, 
Florida International University, 11200 SW 8th St, Miami, United States.
SOURCE
  European journal of trauma and emergency surgery : official publication of 
the European Trauma Society (2019). Date of Publication: 22 May 2019
DATE OF PUBLICATION
  22 May 2019
ISSN
  1863-9941 (electronic)
BOOK PUBLISHER
  NLM (Medline)
ABSTRACT
  PURPOSE: Patients with rib fractures (RF) may require prolonged mechanical 
ventilation and tracheostomy. Indications for tracheostomy in trauma 
patients with RF remain debatable. The goal was to delineate characteristics 
of patients who underwent tracheostomy due to thoracic versus extra-thoracic 
causes, such as maxillofacial-mandibular injury (MFM), traumatic brain 
injury (TBI), and cervical vertebrae trauma (CVT), and to analyze clinical 
outcomes. The predictive values of chest trauma scoring systems for 
tracheostomy were also evaluated. We hypothesized that tracheostomized 
patients were more severely injured with more ribs fractured and had more 
pulmonary co-injuries. METHODS: Retrospective review included 471 patients 
with RF admitted to two Level 1 trauma centers. Patients with tracheostomy 
(n = 124, 26.3%) were compared to patients with endotracheal intubation (n = 
347, 73.7%). Analyzed variables included age, gender, injury severity score 
(ISS), Glasgow Coma Scale, number of ribs fractured, total fractures of 
ribs, prevalence of bilateral rib fractures, flail chest, clavicle 
fractures, MFM, TBI, CVT, co-injuries, comorbidities, RF treatment options, 
hospital length of stay (HLOS), intensive care unit LOS (ICULOS), duration 
of mechanical ventilation (DMV). RESULTS: Tracheostomized compared to 
intubated patients had statistically higher ISS, more ribs fractured, total 
fractures of the ribs, bilateral and clavicle fractures, MFM, spine, chest, 
and orthopedic co-injuries and longer HLOS, ICULOS and DMV. Tracheostomy for 
thoracic reasons was performed in 64 patients (51.6%) and for extra-thoracic 
reasons in 60 patients (48.4%). Mean tracheostomy timing was 9.9 days and 
was significantly shorter in the extra-thoracic compared to the thoracic 
group (8.0 versus 11.6 days, p < 0.001). All chest trauma scoring system 
values were significantly higher in tracheostomized patients. Predictive 
values of scoring systems for tracheostomy increased in patients with 
thoracic trauma only. CONCLUSIONS: A quarter of mechanically ventilated 
patients with RF required tracheostomy. Tracheostomized compared to 
intubated patients were more severely injured with more ribs fractured and 
were intubated longer. An increased amount of RF was associated with an 
increase in tracheostomies, especially for thoracic reasons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  flail chest; scoring system; thorax injury; tracheostomy; traumatic brain injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; clavicle fracture; comorbidity; controlled study; emergency health service; endotracheal intubation; female; gender; Glasgow coma scale; human; intensive care unit; jaw disease; length of stay; major clinical study; male; multicenter study; predictive value; prevalence; retrospective study; rib fracture; spine; ventilated patient; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  31119319 (http://www.ncbi.nlm.nih.gov/pubmed/31119319)
PUI
  L627950406
DOI
  10.1007/s00068-019-01149-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00068-019-01149-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18639941&id=doi:10.1007%2Fs00068-019-01149-7&atitle=Tracheostomy+in+trauma+patients+with+rib+fractures&stitle=Eur+J+Trauma+Emerg+Surg&title=European+journal+of+trauma+and+emergency+surgery+%3A+official+publication+of+the+European+Trauma+Society&volume=&issue=&spage=&epage=&aulast=Fokin&aufirst=Alexander&auinit=A.&aufull=Fokin+A.&coden=&isbn=&pages=-&date=2019&auinit1=A&auinitm=
COPYRIGHT
  This record is sourced from MEDLINE/PubMed, a database of the U.S. National 
Library of Medicine

RECORD 5
TITLE
  Anaesthetic management for caesarean section of a parturient with a known 
difficult airway and closed spinal dysraphism
AUTHOR NAMES
  Katz R.; McCaul C.L.
AUTHOR ADDRESSES
  (Katz R., stackskatz@gmail.com; McCaul C.L.) Department of Anaesthesia, 
Rotunda Hospital, Dublin, Ireland.
CORRESPONDENCE ADDRESS
  R. Katz, Department of Anaesthesia, Rotunda Hospital, Parnell Square East, 
Dublin 1, Ireland. Email: stackskatz@gmail.com
AiP/IP ENTRY DATE
  2018-11-13
FULL RECORD ENTRY DATE
  2019-05-17
SOURCE
  International Journal of Obstetric Anesthesia (2019) 38 (137-142). Date of 
Publication: 1 May 2019
VOLUME
  38
FIRST PAGE
  137
LAST PAGE
  142
DATE OF PUBLICATION
  1 May 2019
ISSN
  1532-3374 (electronic)
  0959-289X
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  Many anaesthetists consider patients with existing neurological deficits, 
untreated spinal pathology or those having undergone major spinal 
intervention to be precluded from undergoing neuraxial anaesthesia. While 
this is partly rooted in fears of litigation there is also a lack of 
consensus of the best practice in the anaesthetic management of these 
patients. We present our management of a parturient who attended our 
institution, having a number of anaesthetic complexities including a known 
difficult airway, spinal fusion and persistent spinal cord tethering. She 
successfully underwent delivery under neuraxial blockade for the delivery of 
her fourth child. We believe that by undergoing a thorough multidisciplinary 
clinical evaluation, including the extensive use of neuroimaging and 
ultrasound, it may be possible to plan and perform safe neuraxial 
anaesthesia.
EMTREE DRUG INDEX TERMS
  bupivacaine (drug dose); fentanyl; metoclopramide; morphine; ranitidine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cesarean section; obstetric analgesia; postoperative analgesia; spinal dysraphism; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; clinical article; clinical evaluation; conus medullaris; echography; ectopic pregnancy; elective surgery; emergency surgery; face mask; female; general anesthesia; gestation period; Harrington instrumentation; human; laparoscopy; laryngoscope; neuroimaging; paresthesia; regional anesthesia; rigid laryngoscope; scoliosis; second lumbar vertebra; spine fusion; supraglottic airway device; third lumbar vertebra; tracheotomy; treatment planning; 
CAS REGISTRY NUMBERS
  bupivacaine (18010-40-7, 2180-92-9, 55750-21-5, 38396-39-3)
  fentanyl (437-38-7)
  metoclopramide (12707-59-4, 2576-84-3, 364-62-5, 7232-21-5)
  morphine (52-26-6, 57-27-2)
  ranitidine (66357-35-5, 66357-59-3)
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30415798 (http://www.ncbi.nlm.nih.gov/pubmed/30415798)
PUI
  L2001253038
DOI
  10.1016/j.ijoa.2018.10.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijoa.2018.10.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15323374&id=doi:10.1016%2Fj.ijoa.2018.10.003&atitle=Anaesthetic+management+for+caesarean+section+of+a+parturient+with+a+known+difficult+airway+and+closed+spinal+dysraphism&stitle=Int.+J.+Obstet.+Anesth.&title=International+Journal+of+Obstetric+Anesthesia&volume=38&issue=&spage=137&epage=142&aulast=Katz&aufirst=R.&auinit=R.&aufull=Katz+R.&coden=IOANE&isbn=&pages=137-142&date=2019&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 6
TITLE
  Open Thoracoabdominal Aortic Aneurysm Repair: Contemporary Outcomes for 393 
Elective Cases
AUTHOR NAMES
  Shimamura J.; Oshima S.; Ozaki K.; Sakurai S.; Hirai Y.; Hirokami T.; Fujikawa T.; Ozaki A.; Yamamoto S.
AUTHOR ADDRESSES
  (Shimamura J., junichi.shimamura@gmail.com; Oshima S.; Ozaki K.; Sakurai S.; 
Hirai Y.; Hirokami T.; Fujikawa T.; Yamamoto S.) Kawasaki Aortic Center, 
Kawasaki Saiwai Hospital, Kawasaki, Japan.
(Ozaki A.) Department of Epidemiology and Biostatistics, Graduate School of 
Public Health, Teikyo University, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  J. Shimamura, Kawasaki Aortic Center, 31-27 Omiya-cho, Saiwai-ku, Kawasaki, 
Japan. Email: junichi.shimamura@gmail.com
AiP/IP ENTRY DATE
  2019-03-26
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Annals of Thoracic Surgery (2019) 107:5 (1326-1332). Date of Publication: 1 
May 2019
VOLUME
  107
ISSUE
  5
FIRST PAGE
  1326
LAST PAGE
  1332
DATE OF PUBLICATION
  1 May 2019
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background: The purpose of this study was to reveal the midterm and 
long-term mortality rates among patients with thoracoabdominal aortic 
aneurysm (TAAA) after open TAAA repair and to clarify the effect of aneurysm 
type on mortality. Methods: We retrospectively analyzed data for 393 
patients (290 men; age, 63.2 ± 12.7 years) who underwent open TAAA repair of 
elective Crawford extent I, II, or III TAAAs (62, 197, and 134 patients, 
respectively) between June 2003 and December 2015. The overall survival 
probability and differences according to aneurysm type were assessed using 
the Kaplan-Meier product limit method. Also, the effect of aneurysm type on 
mortality was assessed using the hazard ratio and Cox proportional hazards 
regression. Results: The overall survival probabilities at 3 months, 1 year, 
5 years, and 10 years were 90%, 84%, 78%, and 75%, respectively. The 
age-adjusted relative mortality rate was significantly higher for patients 
with dissecting aneurysms than for those with nondissecting aneurysms 
(relative risk, 1.62; 95% confidence interval, 1.03 to 2.55). In the 
multivariate Cox proportional hazard regression model, the hazard ratio for 
all-cause mortality did not differ between patients with dissecting and 
those with nondissecting aneurysms. However, those with dissecting aneurysms 
had increased mortality rates as their percentage vital capacity decreased 
(hazard ratio, 0.7; 95% confidence interval, 0.5 to 1.0); a similar trend 
was not observed for those with nondissecting aneurysms. Conclusions: Open 
TAAA repair can be safely performed with acceptable midterm and long-term 
results. Poor pulmonary function can impair the survival outcome of patients 
with dissecting aneurysms.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm surgery; open surgery; thoracoabdominal aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; all cause mortality; article; brain infarction; chronic obstructive lung disease; computer assisted tomography; coronary angiography; diabetes mellitus; dissecting aneurysm (surgery); elective surgery; endovascular aneurysm repair; female; hemodialysis; human; Japan; long term survival; lung function; major clinical study; male; Marfan syndrome; middle aged; mortality rate; nuclear magnetic resonance imaging; operation duration; outcome assessment; overall survival; paraplegia; postoperative complication; priority journal; reoperation; retrospective study; spinal cord injury; surgical mortality; tracheotomy; transthoracic echocardiography; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30552886 (http://www.ncbi.nlm.nih.gov/pubmed/30552886)
PUI
  L2001728254
DOI
  10.1016/j.athoracsur.2018.11.021
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2018.11.021
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2018.11.021&atitle=Open+Thoracoabdominal+Aortic+Aneurysm+Repair%3A+Contemporary+Outcomes+for+393+Elective+Cases&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=107&issue=5&spage=1326&epage=1332&aulast=Shimamura&aufirst=Junichi&auinit=J.&aufull=Shimamura+J.&coden=ATHSA&isbn=&pages=1326-1332&date=2019&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 7
TITLE
  Giant De Novo Pleomorphic Adenoma of Parapharyngeal Space, Can It Cause 
Spinal Deformity? A Case Report
AUTHOR NAMES
  Sagar P.; Rajpurohit P.; Singh I.; Mandal S.
AUTHOR ADDRESSES
  (Sagar P., poonamsgr.mamc@gmail.com; Rajpurohit P.; Singh I.) Department of 
ENT & Head and Neck Surgery, Maulana Azad Medical College and associated Lok 
Nayak hospital, Bahadur Shah Zafar Marg, Delhi, India.
(Mandal S.) Department of Pathology, Maulana Azad Medical College and 
associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, Delhi, India.
CORRESPONDENCE ADDRESS
  P. Sagar, C-11A, Ram Dutt Enclave, Uttam Nagar, New Delhi, India. Email: 
poonamsgr.mamc@gmail.com
AiP/IP ENTRY DATE
  2018-10-25
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Spine Deformity (2019) 7:3 (505-508). Date of Publication: 1 May 2019
VOLUME
  7
ISSUE
  3
FIRST PAGE
  505
LAST PAGE
  508
DATE OF PUBLICATION
  1 May 2019
ISSN
  2212-1358 (electronic)
  2212-134X
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Study Design: Case report. Introduction: De novo giant pleomorphic adenoma 
is a rare tumor of the parapharyngeal space (PPS). Tumors of the PPS can 
grow to a large size, compromising the space of the upper aerodigestive 
tract. However, involvement of the paravertebral region is unexpected. In 
extremely exceptional circumstances, these tumors can produce spinal 
deformity. Case Report: A 25-year-old man presented with a longstanding mass 
in the neck and oral cavity. He had complaints of dysphagia, snoring, and 
restricted neck movements because of the large size of the tumor. Imaging 
showed a large mass occupying the PPS extending to the paravertebral region 
and causing deformity of the cervical spine. Excision was done uneventfully 
via a minimal access transcervical approach. Residual spinal deformity dealt 
with postoperative physiotherapy with improvement in lordosis and lateral 
tilt. No tumor recurrence occurred till 26 months of follow-up. Conclusion: 
Tumors of the PPS can grow to a large size and involve the neck and PPS, 
even causing spinal deformity. Careful evaluation is required for 
ascertaining the origin of the tumor and deciding the treatment plan.
EMTREE DRUG INDEX TERMS
  helium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  giant de novo pleomorphic adenoma (etiology); pharynx tumor; pleomorphic adenoma (etiology); spine malformation (etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; airway; article; bleeding; cancer surgery; case report; cervical spine; clinical article; computer assisted tomography; contrast enhancement; dysphagia; fine needle aspiration biopsy; follow up; histopathology; human; lateral pterygoid muscle; lordosis; male; mouth cavity; neck; neck muscle; neurologic examination; nuclear magnetic resonance imaging; oropharynx; physiotherapy; postoperative care; preoperative care; priority journal; snoring; tracheostomy; tumor recurrence; tumor volume; 
CAS REGISTRY NUMBERS
  helium (7440-59-7)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  31053323 (http://www.ncbi.nlm.nih.gov/pubmed/31053323)
PUI
  L2001200945
DOI
  10.1016/j.jspd.2018.09.009
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jspd.2018.09.009
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22121358&id=doi:10.1016%2Fj.jspd.2018.09.009&atitle=Giant+De+Novo+Pleomorphic+Adenoma+of+Parapharyngeal+Space%2C+Can+It+Cause+Spinal+Deformity%3F+A+Case+Report&stitle=Spine+Deform.&title=Spine+Deformity&volume=7&issue=3&spage=505&epage=508&aulast=Sagar&aufirst=Poonam&auinit=P.&aufull=Sagar+P.&coden=&isbn=&pages=505-508&date=2019&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 8
TITLE
  A Novel Pharyngeal Clearance Maneuver for Initial Tracheostomy Tube Cuff 
Deflation in High Cervical Tetraplegia
AUTHOR NAMES
  Ehsanian R.; Klein C.; Mohole J.; Rrt-Rspt J.C.; Pence B.T.; Crew J.; McKenna S.
AUTHOR ADDRESSES
  (Ehsanian R.; Mohole J.; Rrt-Rspt J.C.; Pence B.T.; Crew J.; McKenna S.) 
Rehabilitation Research Center at Santa Clara Valley Medical Center, San 
Jose, United States.
(Ehsanian R.; McKenna S.) Department of Neurosurgery, Stanford University, 
Australia.
(Klein C.) PM&R Section, Department of Orthopedic Surgery, Stanford 
University, Australia.
SOURCE
  American journal of physical medicine & rehabilitation (2019). Date of 
Publication: 9 Apr 2019
DATE OF PUBLICATION
  9 Apr 2019
ISSN
  1537-7385 (electronic)
BOOK PUBLISHER
  NLM (Medline)
ABSTRACT
  Mechanical insufflation-exsufflation (MIE), or "cough-assist" is a commonly 
used method of clearing tracheal and pulmonary secretions in patients with 
respiratory insufficiency secondary to spinal cord injury (SCI). This report 
presents a novel technique termed the Pharyngeal Clearance Maneuver (PCM) 
which utilizes a modified application of the MIE device to mobilize 
"secretion burden" at the portion of the trachea above the tracheostomy cuff 
during cuff deflation. Utilization of this strategy may reduce the risk of 
aspiration, infection, and respiratory compromise for patients with high 
cervical SCI in the acute rehabilitation setting. It is of particular 
benefit for those whose cuffs are being deflated for the first time and who 
may have large secretion volumes above the cuff. It can be further utilized 
as needed prior to speaking trials and swallow therapies. We anticipate that 
the Pharyngeal Clearance Maneuver may be used in other populations with 
impaired cough and need for invasive ventilator support due to ventilator 
pump failure (e.g. spinal muscular atrophy, congenital myopathies, obesity 
hypoventilation, amyotrophic lateral sclerosis, muscular dystrophy, and 
acute inflammatory demyelinating polyneuropathy).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  clearance; pharynx; pneumatic cuff; quadriplegia; tracheostomy tube; 
EMTREE MEDICAL INDEX TERMS
  acute inflammatory demyelinating polyneuropathy; adult; aeration; amyotrophic lateral sclerosis; article; artificial ventilation; aspiration; bodily secretions; cervical spinal cord injury; congenital disorder; controlled study; coughing; female; human; hypoventilation; infection; muscular dystrophy; non continuous ventilator; obesity; respiratory failure; speech; trachea; treatment failure; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30973517 (http://www.ncbi.nlm.nih.gov/pubmed/30973517)
PUI
  L627332325
DOI
  10.1097/PHM.0000000000001192
FULL TEXT LINK
  http://dx.doi.org/10.1097/PHM.0000000000001192
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15377385&id=doi:10.1097%2FPHM.0000000000001192&atitle=A+Novel+Pharyngeal+Clearance+Maneuver+for+Initial+Tracheostomy+Tube+Cuff+Deflation+in+High+Cervical+Tetraplegia&stitle=Am+J+Phys+Med+Rehabil&title=American+journal+of+physical+medicine+%26+rehabilitation&volume=&issue=&spage=&epage=&aulast=Ehsanian&aufirst=Reza&auinit=R.&aufull=Ehsanian+R.&coden=&isbn=&pages=-&date=2019&auinit1=R&auinitm=
COPYRIGHT
  This record is sourced from MEDLINE/PubMed, a database of the U.S. National 
Library of Medicine

RECORD 9
TITLE
  Development of Clinical Tracheostomy Score to Identify Cervical Spinal Cord 
Injury Patients Requiring Prolonged Ventilator Support
AUTHOR NAMES
  Scantling D.; Granche J.; Williamson J.; Gracely E.; Thosani D.; McCracken B.
AUTHOR ADDRESSES
  (Scantling D.; Williamson J.; Thosani D.; McCracken B.) Hahnemann University 
Hospital, Philadelphia, United States.
(Scantling D.; Williamson J.; Thosani D.; McCracken B.) Drexel University 
College of Medicine, Philadelphia, United States.
(Granche J.; Gracely E.) Dornsife School of Public Health of Drexel 
University, Department of Epidemiology and Biostatistics, Philadelphia, 
United States.
SOURCE
  The journal of trauma and acute care surgery (2019). Date of Publication: 1 
Apr 2019
DATE OF PUBLICATION
  1 Apr 2019
ISSN
  2163-0763 (electronic)
BOOK PUBLISHER
  NLM (Medline)
ABSTRACT
  OBJECTIVES: Cervical spinal cord injuries (CSCI) often necessitate 
ventilator support (VS). Prolonged endotracheal tube use has conveyed 
substantial morbidity in prospective study. Tracheostomy is recommended if 
VS is anticipated to be ≥7 days, which defines prolonged ventilation (PV). 
Identifying these patients on arrival and before tracheostomy need is 
readily evident could prevent morbidity while lowering hospital costs. We 
aimed to create a Tracheostomy Score to identify patients requiring PV and 
who could benefit from immediate tracheostomy. METHODS: A review of patients 
with cervical spine fractures and CSCI from 2005 to 2017 from the 
Pennsylvania Trauma Outcome Study database was performed. Patients were 
excluded for missing data, no use of VS or death in <7 days. Patients were 
selected for a training set or validation set by state identification 
number. We used automated forward stepwise selection to select a logistic 
model. Significant continuous variables were dichotomized to create a 
simplified screening score (Trach Score) and this was applied to the 
validation set. RESULTS: Needing ventilation for 7 or more days was 
positively associated with higher ISS scores, having a complete or anterior 
injury, and having a motor cord injury from C1-C4. Application of the 
logistic model to the validation data produced a ROC curve with AUC = 
0.7712, with 95% CL = (0.6943, 0.8481). The validation ROC curve was 
statistically better than chance using a contrast test with Chi with p < 
.01. In the validation set, a Tracheostomy Score of 0 correlated to 33% 
needing PV, a score of 1 with 67% needing PV, 2 with 85% and 3 with 98%. 
CONCLUSION: Use of the Trach Score identified the majority of patients 
requiring prolonged ventilator support in our study. An early tracheostomy 
protocol using predictive modeling could aid in reduction of ICU length of 
stay and improving ventilator weaning in these patients. External 
verification of this predictive tool and of an early tracheostomy protocol 
is needed. LEVEL OF EVIDENCE: this work is a retrospective prognostic cohort 
study and meets evidence level III criteria.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  adult; area under the curve; article; cervical spine fracture; cohort analysis; controlled study; death; female; hospital cost; human; length of stay; male; morbidity; Pennsylvania; prospective study; receiver operating characteristic; retrospective study; validation process; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30939580 (http://www.ncbi.nlm.nih.gov/pubmed/30939580)
PUI
  L627196901
DOI
  10.1097/TA.0000000000002286
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0000000000002286
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0000000000002286&atitle=Development+of+Clinical+Tracheostomy+Score+to+Identify+Cervical+Spinal+Cord+Injury+Patients+Requiring+Prolonged+Ventilator+Support&stitle=J+Trauma+Acute+Care+Surg&title=The+journal+of+trauma+and+acute+care+surgery&volume=&issue=&spage=&epage=&aulast=Scantling&aufirst=Dane&auinit=D.&aufull=Scantling+D.&coden=&isbn=&pages=-&date=2019&auinit1=D&auinitm=
COPYRIGHT
  This record is sourced from MEDLINE/PubMed, a database of the U.S. National 
Library of Medicine

RECORD 10
TITLE
  Spontaneous spinal epidural hematoma mimicking Guillain-Barre Syndrome
AUTHOR NAMES
  Kondo A.; Yamaguchi H.; Ishida Y.; Toyoshima D.; Azumi M.; Akutsu N.; Koyama J.; Kurosawa H.; Kawamura A.; Maruyama A.
AUTHOR ADDRESSES
  (Kondo A.; Yamaguchi H., hiyamaguchi_kch@hp.pref.hyogo.jp; Ishida Y.; 
Toyoshima D.; Maruyama A.) Department of Neurology, Hyogo Prefectural Kobe 
Children's Hospital, Kobe, Japan.
(Yamaguchi H., hiyamaguchi_kch@hp.pref.hyogo.jp) Department of Pediatrics, 
Kobe University Graduate School of Medicine, Kobe, Japan.
(Azumi M.; Akutsu N.; Koyama J.; Kawamura A.) Department of Neurosurgery, 
Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
(Kurosawa H.) Department of Pediatric Critical Care Medicine, Hyogo 
Prefectural Kobe Children's Hospital, Kobe, Japan.
CORRESPONDENCE ADDRESS
  H. Yamaguchi, Department of Neurology, Hyogo Prefectural Kobe Children's 
Hospital, 1-6-7 Minatojimaminamimachi, Chuo-Ku, Kobe, Japan. Email: 
hiyamaguchi_kch@hp.pref.hyogo.jp
AiP/IP ENTRY DATE
  2018-11-27
FULL RECORD ENTRY DATE
  2019-03-15
SOURCE
  Brain and Development (2019) 41:4 (392-395). Date of Publication: 1 Apr 2019
VOLUME
  41
ISSUE
  4
FIRST PAGE
  392
LAST PAGE
  395
DATE OF PUBLICATION
  1 Apr 2019
ISSN
  1872-7131 (electronic)
  0387-7604
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  Background: The initial symptoms of Guillain-Barre Syndrome (GBS) can be 
similar to a case of spontaneous spinal epidural hematoma (SSEH) located at 
the cervicothoracic junction. Therefore, SSEH may be misdiagnosed as GBS. 
Case Report: A previously healthy 6-year-old girl presented with a 2-day 
history of progressive pain in the lower extremities and an inability to 
walk. On initial evaluation, she was completely paraparetic in the lower 
extremities. Deep tendon reflexes were absent in the lower extremities, and 
Babinski reflexes were positive on both sides. She exhibited reduced 
response to light touch and pinprick with a sensory level below T10, and 
experienced difficulty during urination. However, the strength, sensation 
and flexion of upper extremities were normal. Because her presentation and 
examinations were consistent with GBS, we initiated intravenous 
immunoglobulin therapy. The next day, she also developed pain and muscle 
weakness of the right upper extremity. Three days after admission, 
respiratory depression progressed rapidly. Spinal MRI showed a mass 
extending from the level of C7-T3, with spinal cord compression. The patient 
underwent an emergency laminectomy with evacuation of hematoma, and was 
diagnosed with SSEH. Sixty days after admission, she was transferred to the 
rehabilitation hospital with severe neurologic sequelae of paralysis in both 
legs. Conclusion: SSEH might have severe consequences, including neurologic 
deficits and risk of death. This case report serves to raise the awareness 
of SSEH that mimics the initial presentation of GBS.
EMTREE DRUG INDEX TERMS
  immunoglobulin (drug therapy, intravenous drug administration); methylprednisolone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Guillain Barre syndrome (diagnosis, drug therapy); spinal hematoma (diagnosis, drug therapy, surgery); spontaneous spinal epidural hematoma (diagnosis, drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  article; Babinski reflex; case report; cerebrospinal fluid analysis; child; clinical article; clinical examination; female; fever; hospital admission; human; immunotherapy; laminectomy; leg pain; lower limb; lumbar puncture; medical history; muscle weakness; neuroimaging; neurologic examination; nuclear magnetic resonance imaging; paralysis; paraplegia; preschool child; rehabilitation center; respiration depression; spinal cord compression (drug therapy, surgery); tendon reflex; tension pneumothorax; tracheotomy; upper limb; upper respiratory tract obstruction (surgery); walking difficulty; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30471873 (http://www.ncbi.nlm.nih.gov/pubmed/30471873)
PUI
  L2001306575
DOI
  10.1016/j.braindev.2018.11.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.braindev.2018.11.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18727131&id=doi:10.1016%2Fj.braindev.2018.11.004&atitle=Spontaneous+spinal+epidural+hematoma+mimicking+Guillain-Barre+Syndrome&stitle=Brain+Dev.&title=Brain+and+Development&volume=41&issue=4&spage=392&epage=395&aulast=Kondo&aufirst=Aya&auinit=A.&aufull=Kondo+A.&coden=BDEVD&isbn=&pages=392-395&date=2019&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 11
TITLE
  Midterm Results of 2-Stage Hybrid Arch Repair for Extensive Aortic Arch 
Aneurysms
AUTHOR NAMES
  Yoshitake A.; Iida Y.; Yamazaki M.; Hayashi K.; Inaba Y.; Shimizu H.
AUTHOR ADDRESSES
  (Yoshitake A., akihiro197253@yahoo.co.jp; Iida Y.; Yamazaki M.; Hayashi K.; 
Inaba Y.; Shimizu H.) Department of Cardiovascular Surgery, Keio University 
School of Medicine, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  A. Yoshitake, Department of Cardiovascular Surgery, Keio University School 
of Medicine, 35 Shinanomachi, Shinjuku, Japan. Email: 
akihiro197253@yahoo.co.jp
AiP/IP ENTRY DATE
  2018-11-21
FULL RECORD ENTRY DATE
  2019-04-18
SOURCE
  Annals of Vascular Surgery (2019) 56 (97-102). Date of Publication: 1 Apr 
2019
VOLUME
  56
FIRST PAGE
  97
LAST PAGE
  102
DATE OF PUBLICATION
  1 Apr 2019
ISSN
  1615-5947 (electronic)
  0890-5096
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background: This report evaluated the perioperative and midterm results of 
the 2-stage hybrid arch procedure. This procedure involves total arch 
replacement with an elephant trunk as the first stage and thoracic 
endovascular aortic repair as the second stage for patients with extended 
aortic arch pathology. Methods: Between April 2010 and April 2017, 55 
consecutive patients (age, 74.2 ± 6.4 years) with extended aortic arch 
atherosclerotic pathology involving the aortic arch and descending aorta 
underwent first-stage total arch replacement with the elephant trunk 
procedure. The second stage was completed for 53 (96.4%) of the 55 patients. 
The mean duration between the 2 procedures was 2.4 ± 2.2 months. 
Postoperative follow-up was completed after a mean of 36.6 ± 24.9 months. 
Results: The in-hospital mortality rate for the first stage was 0%. Two 
patients died during the interval between surgeries. The in-hospital 
mortality rate for the second stage was 0%. Two (3.6%) of the 55 first-stage 
patients and none of the 53 second-stage patients experienced a 
postoperative stroke. No spinal cord dysfunction occurred during the 
first-stage and second-stage procedures. The 3- and 5-year survival rates 
were 88.2% and 67.0%, respectively. The 5-year thoracic aortic 
intervention-free rate was 95.5%. Conclusions: Extended aortic arch 
aneurysms were repaired using a 2-stage hybrid arch repair. Perioperative 
mortality and midterm results were acceptable. Use of an elephant trunk 
provided a secure landing zone for thoracic endovascular aneurysm repair. 
This 2-stage hybrid procedure is an alternative approach to extended aortic 
arch pathology.
EMTREE DRUG INDEX TERMS
  polyethylene terephthalate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic aneurysm (surgery); aortic arch; aortic arch aneurysm (surgery); endovascular aneurysm repair; 
EMTREE MEDICAL INDEX TERMS
  aged; air; aneurysm rupture; aortic aneurysm endovascular graft; aortic arch surgery; aortic dissection; aortic prosthesis; aortic valve replacement; artery anastomosis; article; brachiocephalic trunk; cardiopulmonary bypass; cerebrospinal fluid drainage; chronic kidney failure; chronic obstructive lung disease; computer assisted tomography; congestive heart failure; coronary artery bypass graft; descending aorta; descending aortic surgery; endoleak; erythrocyte concentrate; female; femoral artery; follow up; hospital mortality; hospitalization; human; length of stay; major clinical study; male; malignant neoplasm; Marfan syndrome; mortality rate; motor evoked potential; open surgery; operation duration; postoperative care; priority journal; respiratory failure; sepsis; spinal cord function; sternotomy; surgical technique; survival rate; tracheostomy; transluminal coronary angioplasty; very elderly; 
CAS REGISTRY NUMBERS
  polyethylene terephthalate (25038-59-9, 60527-88-0, 9003-68-3)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30342217 (http://www.ncbi.nlm.nih.gov/pubmed/30342217)
PUI
  L2001291036
DOI
  10.1016/j.avsg.2018.07.063
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.avsg.2018.07.063
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16155947&id=doi:10.1016%2Fj.avsg.2018.07.063&atitle=Midterm+Results+of+2-Stage+Hybrid+Arch+Repair+for+Extensive+Aortic+Arch+Aneurysms&stitle=Ann.+Vasc.+Surg.&title=Annals+of+Vascular+Surgery&volume=56&issue=&spage=97&epage=102&aulast=Yoshitake&aufirst=Akihiro&auinit=A.&aufull=Yoshitake+A.&coden=AVSUE&isbn=&pages=97-102&date=2019&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 12
TITLE
  Gender-related outcomes after open repair of descending thoracic and 
thoracoabdominal aortic aneurysms
AUTHOR NAMES
  Girardi L.N.; Leonard J.R.; Lau C.; Ohmes L.B.; Gambardella I.; Iannacone E.M.; Munjal M.; Schwann A.N.; Gaudino M.F.L.
AUTHOR ADDRESSES
  (Girardi L.N., lngirard@med.cornell.edu; Leonard J.R.; Lau C.; Ohmes L.B.; 
Gambardella I.; Iannacone E.M.; Munjal M.; Schwann A.N.; Gaudino M.F.L.) 
Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, 
United States.
CORRESPONDENCE ADDRESS
  L.N. Girardi, Department of Cardiothoracic Surgery, Weill Cornell Medicine, 
525 E 68th St, M-404, New York, United States. Email: 
lngirard@med.cornell.edu
AiP/IP ENTRY DATE
  2018-10-08
FULL RECORD ENTRY DATE
  2019-03-27
SOURCE
  Journal of Vascular Surgery (2019) 69:4 (1028-1035.e1). Date of Publication: 
1 Apr 2019
VOLUME
  69
ISSUE
  4
FIRST PAGE
  1028
LAST PAGE
  1035.e1
DATE OF PUBLICATION
  1 Apr 2019
ISSN
  1097-6809 (electronic)
  0741-5214
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Objective: Female sex has been associated with greater morbidity and 
mortality for a variety of major cardiovascular procedures. We sought to 
determine the influence of female sex on early and late outcomes after open 
descending thoracic aortic aneurysm (DTA) and thoracoabdominal aortic 
aneurysm (TAAA) repair. Methods: We searched our aortic surgery database to 
identify patients having open DTA or TAAA repair. Logistic regression and 
Cox regression analyses were used to assess the effect of sex on 
perioperative and long-term outcomes. Results: From 1997 until 2017, there 
were 783 patients who underwent DTA or TAAA repair. There were 462 male 
patients and 321 female patients. Female patients were significantly older 
(67.6 ± 13.9 years vs 62.6 ± 14.7 years; P <.001), had more chronic 
pulmonary disease (47.0% vs 35.7%; P =.001) and forced expiratory volume in 
1 second <50% (28.3% vs 18.2%; P <.001), and were more likely to have 
degenerative aneurysms (61.7% vs 41.6%; P <.001). Operative mortality was 
not different between women and men (5.6% vs 6.2%; P =.536). However, women 
were more likely to require a tracheostomy after surgery (10.6% vs 5.0%; P 
=.003) despite a reduced incidence of left recurrent nerve palsy (3.4% vs 
7.8%; P =.012). Logistic regression found female sex to be an independent 
risk factor for a composite of major adverse events (odds ratio, 2.68; 
confidence interval, 1.41-5.11) and need for tracheostomy (odds ratio, 3.73; 
confidence interval, 1.53-9.10). Women also had significantly lower 5-year 
survival. Conclusions: Women undergoing open DTA or TAAA repair are not at 
greater risk for operative mortality than their male counterparts are. 
Reduced preoperative pulmonary function may contribute to an increased risk 
for respiratory failure in the perioperative period.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  sex difference; thoracic aorta aneurysm (surgery); thoracoabdominal aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; artery transplantation; article; cerebrospinal fluid drainage; chronic lung disease; chronic obstructive lung disease; cohort analysis; connective tissue disease; female; follow up; forced expiratory volume; heart ejection fraction; human; major clinical study; male; middle aged; outcome assessment; perioperative period; postoperative period; preoperative period; priority journal; recurrent laryngeal nerve palsy; spinal cord injury; surgical mortality; survival; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30292619 (http://www.ncbi.nlm.nih.gov/pubmed/30292619)
PUI
  L2001153096
DOI
  10.1016/j.jvs.2018.06.213
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jvs.2018.06.213
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10976809&id=doi:10.1016%2Fj.jvs.2018.06.213&atitle=Gender-related+outcomes+after+open+repair+of+descending+thoracic+and+thoracoabdominal+aortic+aneurysms&stitle=J.+Vasc.+Surg.&title=Journal+of+Vascular+Surgery&volume=69&issue=4&spage=1028&epage=1035.e1&aulast=Girardi&aufirst=Leonard+N.&auinit=L.N.&aufull=Girardi+L.N.&coden=JVSUE&isbn=&pages=1028-1035.e1&date=2019&auinit1=L&auinitm=N
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 13
TITLE
  Multidisciplinary surgical planning for en bloc resection of malignant 
primary cervical spine tumors involving 3D-printed models and neoadjuvant 
therapies: Report of 2 cases
AUTHOR NAMES
  Karim Ahmed A.; Pennington Z.; Molina C.A.; Xia Y.; Goodwin C.R.; Sciubba D.M.
AUTHOR ADDRESSES
  (Karim Ahmed A.; Pennington Z.; Molina C.A.; Xia Y.; Sciubba D.M., 
dsciubb1@jhmi.edu) Department of Neurosurgery, Johns Hopkins School of 
Medicine, Baltimore, United States.
(Goodwin C.R.) Department of Neurosurgery, Duke University Medical Center, 
Durham, United States.
CORRESPONDENCE ADDRESS
  D.M. Sciubba, Department of Neurosurgery, Johns Hopkins School of Medicine, 
Baltimore, United States. Email: dsciubb1@jhmi.edu
AiP/IP ENTRY DATE
  2019-05-14
FULL RECORD ENTRY DATE
  2019-05-20
SOURCE
  Journal of Neurosurgery: Spine (2019) 30:4 (424-431). Date of Publication: 1 
Apr 2019
VOLUME
  30
ISSUE
  4
FIRST PAGE
  424
LAST PAGE
  431
DATE OF PUBLICATION
  1 Apr 2019
ISSN
  1547-5646 (electronic)
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons
ABSTRACT
  Effective en bloc resection of primary spinal tumors necessitates careful 
consideration of adjacent anatomical structures in order to achieve negative 
margins and reduce surgical morbidity. This can be particularly challenging 
in the cervical spine, where vital neurovascular and connective tissues are 
present in the region. Early multidisciplinary surgical planning that 
includes clinicians and engineers can both optimize surgical planning and 
enable a more feasible resection with oncological margins. The aim of the 
current work was to demonstrate two cases that involved multidisciplinary 
surgical planning for en bloc resection of primary cervical spine tumors, 
successfully utilizing 3D-printed patient models and neoadjuvant therapies.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  doxorubicin (drug therapy); ifosfamide (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer surgery; neoadjuvant chemotherapy; primary tumor (drug therapy, radiotherapy, surgery); spine tumor (drug therapy, radiotherapy, surgery); three dimensional printing; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cancer radiotherapy; cancer staging; case report; chordoma; clinical article; computed tomographic angiography; hand paresthesia; human; laminectomy; left common carotid artery; liquorrhea; male; middle aged; mobile x ray unit; multidisciplinary team; myxosarcoma; neck pain; pedicle screw; plastic surgery; positron emission tomography-computed tomography; preoperative chemotherapy; radiation oncology; radiosensitivity; stereotactic body radiation therapy; sternocleidomastoid muscle; thyroid gland; tracheostomy; tumor volume; wound infection; young adult; 
CAS REGISTRY NUMBERS
  doxorubicin (23214-92-8, 25316-40-9)
  ifosfamide (3778-73-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L2001877057
DOI
  10.3171/2018.9.SPINE18607
FULL TEXT LINK
  http://dx.doi.org/10.3171/2018.9.SPINE18607
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475646&id=doi:10.3171%2F2018.9.SPINE18607&atitle=Multidisciplinary+surgical+planning+for+en+bloc+resection+of+malignant+primary+cervical+spine+tumors+involving+3D-printed+models+and+neoadjuvant+therapies%3A+Report+of+2+cases&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=30&issue=4&spage=424&epage=431&aulast=Karim+Ahmed&aufirst=&auinit=A.&aufull=Karim+Ahmed+A.&coden=&isbn=&pages=424-431&date=2019&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 14
TITLE
  Impact of a quality improvement program on the neurological outcome of 
patients with traumatic spinal cord injury. A before-after mono-centric 
study
AUTHOR NAMES
  Cinotti R.; Demeure Dit Latte D.; Mahe P.J.; Langlais P.; Grillot N.; Bouras M.; Bourdiol A.; Rooze P.; Buffenoir K.; Perrouin-Verbe B.; Vibet M.-A.; Asehnoune K.; Roquilly A.
AUTHOR ADDRESSES
  (Cinotti R., raphael.cinotti@chu-nantes.fr; Langlais P., 
paullanglais@gmail.com; Grillot N., nicolas.grillot@chu-nantes.fr; Bouras 
M., m_bouras@hotmail.fr; Bourdiol A., alexandre.bourdiol29@gmail.com; Rooze 
P., paulrooze1@gmail.com) CHU, Anesthésie-Réanimation, Nantes, France ;
(Demeure Dit Latte D., dominique.demeureditlatte@chu-nantes.fr; Mahe P.J., 
pierrejoachim.mahe@chu-nantes.fr; Asehnoune K., 
karim.asehnoune@chu-nantes.fr) Nantes, France ;
(Buffenoir K., kevin.buffenoirbillet@chu-nantes.fr) CHU de Nantes, 
Neurosurgery and neurotraumaology , 1, place Alexis Ricordeau , Nantes, 
France , 44093 ;
(Perrouin-Verbe B., brigitte.perrouinverbe@chu-nantes.fr) CHU, Physical 
medicine and rehabilitation department, Nantes, France ;
(Vibet M.-A., marie-anne.vibet@univ-nantes.fr) University, Mathematics, 
Nantes, France ;
(Roquilly A., antoine.roquilly@chu-nantes.Fr) 1 place Alexis 
RicordeauNantes, France , 44093 ;
SOURCE
  Journal of neurotrauma (2019). Date of Publication: 23 Mar 2019
DATE OF PUBLICATION
  23 Mar 2019
ISSN
  1557-9042 (electronic)
BOOK PUBLISHER
  NLM (Medline)
ABSTRACT
  Spine Cord Injury (SCI) is a major cause of severe disability. This study 
aims to assess the effectiveness of a quality improvement program on 
neurological recovery after SCI. Before-after study during two phases in one 
intensive care unit in a University Hospital. The quality improvement 
project comprised protective mechanical ventilation, early tracheostomy in 
anatomical injury above the 6th cervical vertebra, early enteral nutrition, 
early mobilization and active perineal care, in adult SCI patients. Primary 
endpoint was the difference between the ASIA motor score between discharge 
and ICU admission (Delta ASIA). Fifty-seven and 60 patients were included in 
the control and in the intervention period respectively. The ASIA motor 
score upon ICU admission was 16 (7-37) before and 11 (2-30) after the 
implementation (p=0.30). The implementation phase was associated with lower 
tidal volumes (p<0.001), higher PEEP (p<0.001), earlier tracheostomy 
(p=0.01), earlier enteral nutrition initiation (p<0.05), earlier 
mobilization (p<0.05) and more active perineal care (p<0.05). The Delta ASIA 
was +16 [4-32] after vs +6 [0-14] before the intervention (p<0.05). After 
adjustment for potential cofounders, the intervention phase was 
significantly associated with higher Delta ASIA (β coefficient 11.4, 
CI95[1.9-21], p=0.01) in multivariable analysis. No secular time trend 
unrelated to the intervention was highlighted. One-year after trauma, the 
Delta ASIA was higher in the intervention period than in the control period 
(+34 [15-60] vs. +11 [0-33], p<0.05). After adjustment on potential 
confounders, an early in-ICU rehabilitation program in SCI patients was 
associated with higher neurological score upon ICU-discharge.
EMTREE DRUG INDEX TERMS
  nutrition supplement; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  nervous system; spinal cord injury; total quality management; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; article; cervical vertebra; comparative effectiveness; controlled study; disability; female; human; intensive care unit; major clinical study; male; mobilization; perineal care; positive end expiratory pressure; tidal volume; tracheostomy; university hospital; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30907244 (http://www.ncbi.nlm.nih.gov/pubmed/30907244)
PUI
  L627029959
DOI
  10.1089/neu.2018.6298
FULL TEXT LINK
  http://dx.doi.org/10.1089/neu.2018.6298
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15579042&id=doi:10.1089%2Fneu.2018.6298&atitle=Impact+of+a+quality+improvement+program+on+the+neurological+outcome+of+patients+with+traumatic+spinal+cord+injury.+A+before-after+mono-centric+study&stitle=J.+Neurotrauma&title=Journal+of+neurotrauma&volume=&issue=&spage=&epage=&aulast=Cinotti&aufirst=Raphael&auinit=R.&aufull=Cinotti+R.&coden=&isbn=&pages=-&date=2019&auinit1=R&auinitm=
COPYRIGHT
  This record is sourced from MEDLINE/PubMed, a database of the U.S. National 
Library of Medicine

RECORD 15
TITLE
  The role of polysomnography in decannulation of children with brain and 
spinal cord injuries
AUTHOR NAMES
  Morrow A.K.; Tunkel D.E.; Collaco J.M.; McGrath-Morrow S.A.; Lam J.C.; Accardo J.A.; Rybczynski S.V.
AUTHOR ADDRESSES
  (Morrow A.K., morrowa@kennedykrieger.org; Rybczynski S.V.) Department of 
Pediatric Rehabilitation Medicine, Kennedy Krieger Institute, Baltimore, 
United States.
(Morrow A.K., morrowa@kennedykrieger.org) Department of Physical Medicine 
and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, 
United States.
(Tunkel D.E.) Department of Otolaryngology–Head and Neck Surgery, Johns 
Hopkins University School of Medicine, Baltimore, United States.
(Collaco J.M.; McGrath-Morrow S.A.) Eudowood Division of Pediatric 
Respiratory Sciences, Johns Hopkins University School of Medicine, 
Baltimore, United States.
(Lam J.C.) Department of Neurology and Developmental Medicine, Kennedy 
Krieger Institute, Baltimore, United States.
(Accardo J.A.) Departments of Pediatrics and Neurology, Virginia 
Commonwealth University School of Medicine and Children's Hospital of 
Richmond Child Development Clinic, Richmond, United States.
(Rybczynski S.V.) Department of Pediatrics, Johns Hopkins University School 
of Medicine, Baltimore, United States.
CORRESPONDENCE ADDRESS
  A.K. Morrow, Department of Pediatric Rehabilitation Medicine, Kennedy 
Krieger Institute, Baltimore, United States. Email: 
morrowa@kennedykrieger.org
AiP/IP ENTRY DATE
  2018-12-18
FULL RECORD ENTRY DATE
  2019-02-19
SOURCE
  Pediatric Pulmonology (2019) 54:3 (333-341). Date of Publication: 1 Mar 2019
VOLUME
  54
ISSUE
  3
FIRST PAGE
  333
LAST PAGE
  341
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  1099-0496 (electronic)
  8755-6863
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Objective: The objective of this retrospective review was to determine the 
utility of polysomnography (PSG) in influencing the decision to decannulate 
pediatric patients with brain and spinal cord injuries in an inpatient 
rehabilitation hospital setting. Methods: Between 2010 and 2016, data were 
collected on pediatric patients with brain and/or spinal cord injuries who 
had PSG performed with the goal of decannulation. Patients underwent a 
decannulation protocol involving toleration of continuous tracheostomy 
capping and bedside tracheoscopy by otolaryngology. Decision to decannulate 
was determined with input from multiple disciplines. Associations were 
examined between decannulation success and findings on PSG as well as 
demographic factors, injury characteristics, otolaryngology findings, and 
timeline from initial injury to selected events. Results: A total of 46 
patients underwent PSG, after which 38 (83%) were deemed appropriate and 
eight (17%) were deemed inappropriate for decannulation. Individuals who 
were deemed ready for decannulation had significantly lower obstructive 
apnea hypopnea indexes (AHI) (1.7 vs 5.4 events/h, P = 0.03), respiratory 
disturbance indexes (RDI) (2.4 vs 7.6 events/h, P = 0.006), and peak end 
tidal carbon dioxide (CO(2)) levels (50.0 vs 58.7 torr, P = 0.009) on PSG 
compared to those who were not decannulated. There were no complications 
following decannulation prior to discharge. Conclusion: PSG provided 
important additional information as part of a multidisciplinary team 
assessment of clinical readiness for decannulation in pediatric patients 
with brain and spinal cord injuries who underwent a decannulation protocol. 
Obstructive AHI, RDI, and peak end tidal CO(2) level were associated with 
successful decannulation prior to discharge from inpatient rehabilitation.
EMTREE DRUG INDEX TERMS
  carbon dioxide (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; decannulation; polysomnography; spinal cord injury; tube removal; 
EMTREE MEDICAL INDEX TERMS
  adolescent; apnea hypopnea index; child; clinical article; clinical decision making; controlled study; female; human; male; priority journal; respiratory disturbance index; retrospective study; review; tracheostomy; 
CAS REGISTRY NUMBERS
  carbon dioxide (124-38-9, 58561-67-4)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30548191 (http://www.ncbi.nlm.nih.gov/pubmed/30548191)
PUI
  L625443869
DOI
  10.1002/ppul.24208
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.24208
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10990496&id=doi:10.1002%2Fppul.24208&atitle=The+role+of+polysomnography+in+decannulation+of+children+with+brain+and+spinal+cord+injuries&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=54&issue=3&spage=333&epage=341&aulast=Morrow&aufirst=Amanda+K.&auinit=A.K.&aufull=Morrow+A.K.&coden=PEPUE&isbn=&pages=333-341&date=2019&auinit1=A&auinitm=K
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 16
TITLE
  Outcome improving in patients with spinal muscle atrophy
AUTHOR NAMES
  Artemenko V.; Plotnaya E.
AUTHOR ADDRESSES
  (Artemenko V.; Plotnaya E.) MEDICAP, Anesthethia and ICU, Odessa, Ukraine.
CORRESPONDENCE ADDRESS
  V. Artemenko, MEDICAP, Anesthethia and ICU, Odessa, Ukraine.
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Critical Care (2019) 23 Supplement 2. Date of Publication: 1 Mar 2019
VOLUME
  23
DATE OF PUBLICATION
  1 Mar 2019
CONFERENCE NAME
  39th International Symposium on Intensive Care and Emergency Medicine
CONFERENCE LOCATION
  Brussels, Belgium
CONFERENCE DATE
  2019-03-19 to 2019-03-22
ISSN
  1466-609X
BOOK PUBLISHER
  BioMed Central Ltd.
ABSTRACT
  Introduction: In Ukraine, 150 pts with Spinal Muscle Atrophy(SMApts.) are 
registered. The weakness of respiratory muscles leads to their ICU 
admission, intubation, followed with tracheostomy. They can't leave ICU. ICU 
LOS is about 823 days. Other option is extubation according to the Dr J R. 
Bach protocol (Dr. Bach pr). Our purpose: to evaluate the efficacy and 
possibility to implement Dr. Bach pr. in Ukraine. Methods: A prospective 
uncontrolled observational study in 2017-18 in 4 Ukrainian hospitals. 10 
SMA-pts from 6-18 mo were involved. All pts. ready for extubation: afebrile, 
no infiltrations on chest x-ray, normal WBC. However, each SMA-pts. failed 
SBT (T-tube or PSV). We evaluated: extubation success (no reintubation in 48 
hours), ICU LOS, one year survival. Three pts. were excluded: two pts. by 
staff decision, 1 family have choosen tracheostomy. 7 SMA-pts. included. A 
cuff leakage test performed - with a negative, dexamethazone 1mg IV was 
administered. After extubation NIV was started by Ventilogik LS in ST mode 
via nasal mask Giraffe. The EPAP and IPAP settings were titrated to reach 
the chest excursion and target levels of SpO2 (92-96%) and EtCO2 (40-45 
mmHg). A sputum was draining by mechanical insufflation-excuflation (MIE) 
and aspirator Results: All pts, were extubated successful. The mean ICU LOS 
was 8.5 days (7-10 days), one year survival rate was 100%, respiratory 
failure fully compensated by NIV, there was no ICU admission. Every SMA-pts. 
are in good condition, gaining weight Conclusions 1. Dr. Bach pr. allowed 
successful extubation in 100% of SMA-pts. 2. Dr. Bach pr implementation in 
the country could reduced ICU LOS. 3. Furure implementation of method is 
necessary in SMA-pts in Ukraine.
EMTREE DRUG INDEX TERMS
  dexamethasone; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  aeration; artificial ventilation; body weight; breathing muscle; comparative effectiveness; conference abstract; controlled study; extubation; female; human; infant; intubation; major clinical study; male; multicenter study; nose; observational study; pneumatic cuff; prospective study; respiratory failure; sputum; staff; survival rate; T tube; thorax radiography; tracheostomy; Ukraine; weakness; 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L627252367
DOI
  10.1186/s13054-019-2358-0
FULL TEXT LINK
  http://dx.doi.org/10.1186/s13054-019-2358-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1466609X&id=doi:10.1186%2Fs13054-019-2358-0&atitle=Outcome+improving+in+patients+with+spinal+muscle+atrophy&stitle=Crit.+Care&title=Critical+Care&volume=23&issue=&spage=&epage=&aulast=Artemenko&aufirst=V.&auinit=V.&aufull=Artemenko+V.&coden=&isbn=&pages=-&date=2019&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 17
TITLE
  Novel technique of coregistered intraoperative computed tomography and 
preoperative magnetic resonance imaging and diffusion tensor imaging 
navigation in spinal cord tumor resection
AUTHOR NAMES
  Scullen T.; Riffledo J.; Koga S.; Kalyvas J.
AUTHOR ADDRESSES
  (Scullen T.; Riffledo J.; Koga S.; Kalyvas J., james.kalyvas@ochsner.org) 
Department of Neurological Surgery, Ochsner Clinic Foundation, New Orleans, 
United States.
(Scullen T.; Riffledo J.; Kalyvas J., james.kalyvas@ochsner.org) Tulane 
University School of Medicine, Tulane University, New Orleans, United 
States.
(Koga S.) Division of Neurological Surgery, Ochsner Neuroscience 
Institute–North Shore Region, Covington, United States.
(Koga S.; Kalyvas J., james.kalyvas@ochsner.org) The University of 
QueenslandFaculty of Medicine, Ochsner Clinical School, New Orleans, United 
States.
CORRESPONDENCE ADDRESS
  J. Kalyvas, Department of Neurological Surgery, Ochsner Clinic Foundation, 
1514 Jefferson Hwy., New Orleans, United States. Email: 
james.kalyvas@ochsner.org
AiP/IP ENTRY DATE
  2019-05-24
FULL RECORD ENTRY DATE
  2019-05-29
SOURCE
  Ochsner Journal (2019) 19:1 (43-48). Date of Publication: 1 Mar 2019
VOLUME
  19
ISSUE
  1
FIRST PAGE
  43
LAST PAGE
  48
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  1524-5012
BOOK PUBLISHER
  Ochsner Clinic, ocjournal@ochsner.org
ABSTRACT
  Background: Intradural spinal tumors are surgically challenging lesions, and 
intraoperative spinal navigation offers clear potential assistance. While 
intraoperative computed tomography (iCT) of bony anatomy is routinely 
performed, coregistration with magnetic resonance imaging (MRI) and 
diffusion tensor imaging (DTI) to facilitate intradural spinal tumor 
resection is not widely described. We present 2 cases in which iCT was 
coregistered with MRI and DTI for navigational guidance in the resection of 
intradural spinal tumors to assess technical feasibility and surgical 
efficacy. Case Series: Navigation using coregistered iCT/MRI was used in the 
resection of one extramedullary and one intramedullary cervicomedullary 
tumor. The iCT was obtained following open midline exposure of bony anatomy. 
The images were then coregistered with preoperative MRI sequences to allow 
for optical tracking navigation via an optical tracking station (Brainlab). 
For the intramedullary tumor, preoperative DTI sequences were also 
coregistered for enhanced identification of relevant anatomy. Navigational 
accuracy for all cases was confirmed to be acceptable at the level of the 
posterior bony elements, the dura, and the tumor-parenchyma interface. 
Conclusion: The coregistration of preoperative MRI sequences and iCT images 
allowed for meaningfully enhanced navigation during resection. In the case 
involving the intramedullary cervicomedullary tumor with marked distortion 
of longitudinal tracts, iCT/DTI navigation allowed for accurate 
visualization of critical structures and facilitated delineation of tumor 
margins that otherwise would have been difficult. The use of combined iCT 
and preoperative MRI/DTI neuronav-igational guidance is an effective 
approach in the resection of intradural extramedullary and intramedullary 
spinal cord tumors.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  computer assisted tomography; diffusion tensor imaging; neuronavigation; peroperative care; preoperative evaluation; spinal cord tumor (surgery, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; arthrodesis; article; bradycardia; case report; clinical article; craniectomy; dysmetria; female; follow up; foraminotomy; human; hypertension; laminectomy; leg pain; male; nerve compression; nerve decompression; neurofibromatosis type 1 (diagnosis, surgery); posterior spine fusion; pseudarthrosis; somatosensory evoked potential; spine surgery; subependymoma (surgery, diagnosis); tracheostomy; vertebral canal stenosis; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L2001912124
DOI
  10.31486/toj.18.0107
FULL TEXT LINK
  http://dx.doi.org/10.31486/toj.18.0107
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15245012&id=doi:10.31486%2Ftoj.18.0107&atitle=Novel+technique+of+coregistered+intraoperative+computed+tomography+and+preoperative+magnetic+resonance+imaging+and+diffusion+tensor+imaging+navigation+in+spinal+cord+tumor+resection&stitle=Ochsner+J.&title=Ochsner+Journal&volume=19&issue=1&spage=43&epage=48&aulast=Scullen&aufirst=Tyler&auinit=T.&aufull=Scullen+T.&coden=OJCOA&isbn=&pages=43-48&date=2019&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 18
TITLE
  Use of nonsteroidal anti-inflammatory drugs to prevent heterotopic 
ossification after spinal cord injury: a retrospective chart review
AUTHOR NAMES
  Zakrasek E.C.; Yurkiewicz S.M.; Dirlikov B.; Pence B.T.; Crew J.D.
AUTHOR ADDRESSES
  (Zakrasek E.C., dr.zakrasek@gmail.com) Palo Alto Veterans Affairs Hospital, 
Palo Alto, United States.
(Zakrasek E.C., dr.zakrasek@gmail.com; Yurkiewicz S.M.) Stanford Hospitals 
and Clinics, Palo Alto, United States.
(Zakrasek E.C., dr.zakrasek@gmail.com; Dirlikov B.; Pence B.T.; Crew J.D.) 
Santa Clara Valley Medical Center, San Jose, United States.
CORRESPONDENCE ADDRESS
  E.C. Zakrasek, Palo Alto Veterans Affairs Hospital, Palo Alto, United 
States. Email: dr.zakrasek@gmail.com
AiP/IP ENTRY DATE
  2018-10-02
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Spinal Cord (2019) 57:3 (214-220). Date of Publication: 1 Mar 2019
VOLUME
  57
ISSUE
  3
FIRST PAGE
  214
LAST PAGE
  220
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study Design: Retrospective chart review. Objectives: The objective of this 
study is to evaluate the efficacy of nonsteroidal anti-inflammatory drug 
(NSAID) prophylaxis for heterotopic ossification (HO) in the acute phase 
after spinal cord injury (SCI). Setting: Acute rehabilitation hospital in 
California, USA. Methods: This retrospective chart review (October 
2013–March 2017) included individuals with motor complete SCI followed by 
the SCI service within 60 days of injury. Group demographics and HO 
diagnosis were compared in those who received and those who did not receive 
NSAID prophylaxis. A backward stepwise multiple regression was employed to 
assess the predictive association between injury characteristics and HO 
prophylaxis on HO diagnosis. Results: A total of 108 AIS A and B cases were 
included, and 27 received ≥ 15 days of therapy (overall range 6–44 days). 
Logistic regression analysis revealed those who received ≥ 15 days of NSAID 
prophylaxis had an odds ratio of 0.1 of being diagnosed with HO compared 
with those who did not (95% CI, 0.02 to 0.52). Significant predictors of HO 
diagnosis were tracheostomy (OR 2.8, 95% CI, 1.05 to 7.5), urinary tract 
infection (OR 4.3, 95% CI, 1.5 to 12.2), and pressure injury (OR 3.3, 95% 
CI, 1.1 to 9.5). Adverse effects of NSAID use were minimal. Conclusions: 
NSAID prophylaxis appears to help prevent HO development during the acute 
phase after SCI. Prospective study with prolonged follow up is necessary to 
confirm the long-term efficacy of HO prevention and to further evaluate 
safety following spinal fusion. Sponsorship: None.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nonsteroid antiinflammatory agent (adverse drug reaction, drug therapy); 
EMTREE DRUG INDEX TERMS
  bisphosphonic acid derivative (drug therapy); celecoxib (adverse drug reaction, drug therapy); ibuprofen (drug therapy); indometacin (adverse drug reaction, drug therapy); warfarin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  heterotopic ossification (diagnosis, drug therapy, prevention); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (side effect); adult; article; disease association; drug efficacy; drug substitution; drug use; drug withdrawal; gastrointestinal symptom (side effect); hematoma (side effect); hematuria (side effect); hemoptysis (side effect); human; hypercalcemia (drug therapy); injury; length of stay; male; medical record review; priority journal; quadriplegia; rectum hemorrhage (side effect); retrospective study; spasticity; tracheostomy; treatment duration; United States; urinary tract infection; 
CAS REGISTRY NUMBERS
  celecoxib (169590-42-5)
  ibuprofen (15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6)
  indometacin (53-86-1, 74252-25-8, 7681-54-1)
  warfarin (129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30254206 (http://www.ncbi.nlm.nih.gov/pubmed/30254206)
PUI
  L624056779
DOI
  10.1038/s41393-018-0199-3
FULL TEXT LINK
  http://dx.doi.org/10.1038/s41393-018-0199-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fs41393-018-0199-3&atitle=Use+of+nonsteroidal+anti-inflammatory+drugs+to+prevent+heterotopic+ossification+after+spinal+cord+injury%3A+a+retrospective+chart+review&stitle=Spinal+Cord&title=Spinal+Cord&volume=57&issue=3&spage=214&epage=220&aulast=Zakrasek&aufirst=Elissa+C.&auinit=E.C.&aufull=Zakrasek+E.C.&coden=SPCOF&isbn=&pages=214-220&date=2019&auinit1=E&auinitm=C
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 19
TITLE
  Early diagnosis and speed to effect in spinal muscular atrophy type 1 
(SMA-1)
AUTHOR NAMES
  Dabbous O.; Droege M.; Feltner D.E.; Novack A.; Menier M.; Sproule D.M.
AUTHOR ADDRESSES
  (Dabbous O.; Droege M.; Feltner D.E.; Novack A.; Menier M.; Sproule D.M.) 
AveXis, Inc., Bannockburn (États-Unis d'Amérique), France.
CORRESPONDENCE ADDRESS
  O. Dabbous, AveXis, Inc., Bannockburn (États-Unis d'Amérique), France.
FULL RECORD ENTRY DATE
  2019-05-17
SOURCE
  Neuropediatrics (2019) 50 Supplement 1. Date of Publication: 1 Mar 2019
VOLUME
  50
DATE OF PUBLICATION
  1 Mar 2019
CONFERENCE NAME
  47th Annual Meeting of the Societe Europeenne de Neurologie Pediatrique, 
SENP 2019
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2019-03-22 to 2019-03-23
ISSN
  1439-1899
BOOK PUBLISHER
  Hippokrates Verlag GmbH
ABSTRACT
  Objectives: Spinal muscular atrophy type 1SMA-1 is a rapidly progressing 
disease resulting in death or need for permanent ventilation by 2 years of 
age? early intervention with disease modifying treatment is critical. In the 
pivotal phase 3 nusinersen study (ENDEAR? NCT02193074), approximately 10% of 
patients died/required permanent ventilation within 2 months after 
initiation of therapy (time required for four loading doses)? 39% of 
patients died/required permanent ventilation by 6 months from dosing. This 
may reflect a nonimmediate therapeutic impact related to the loading dose 
schedule. This study explored rapidity of therapeutic effect of onasemnogene 
abeparvovec (AVXS-101) gene-replacement therapy (CL-101 phase 1 study? 
NCT02122952), as measured by early changes in children's hospital of 
Philadelphia infant test of neuromuscular disorders (CHOP-INTEND) score, 
compared with the response to nusinersen in ENDEAR (≤ 5-point increase at 2 
months postdosing). Methods: Symptomatic SMA-1 infants were treated with a 
one-time AVXS-101 intravenous injection (cohort 2? n = 12? 24 months 
follow-up). Outcomes of interest were event-free survival (EFS? CL-101: 
death or ≥ 16 hours ventilation/day for > 2 weeks? ENDEAR: death, 
tracheostomy, or ≥ 16 hours ventilation/day for > 21 days) and motor 
function improvements from baseline using CHOP-INTEND. All 12 
AVXS-101-treated patients showed EFS at study end, versus 49/80 (61%) 
nusinersen patients. At 1, 3, and roughly 10 months post-AVXS-101 treatment, 
CHOP-INTEND increased 9.8, 15.4, and 27 points, respectively. At 2 and 
roughly 10 months postnusinersen initiation, CHOP-INTEND increased ≤ 5 and 
approximately 10 points, respectively. By 6 months, 11/12 (92%) 
AVXS-101-treated patients achieved CHOP-INTEND scores ≥ 40 versus 30/78 
(38.5%) nusinersen-treated patients at last interim data-cut (day 183-394). 
Conclusion: AVXS-101 appears to improve survival and induce more rapid motor 
function improvements compared with nusinersen. Advances in understanding 
SMA underscores the need for early diagnosis and treatments with a 
near-immediate onset of action to maximize clinical improvements.
EMTREE DRUG INDEX TERMS
  nusinersen; onasemnogene abeparvovec; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  early diagnosis; velocity; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; child; cohort analysis; conference abstract; controlled study; death; drug dose regimen; drug therapy; event free survival; female; follow up; gene replacement therapy; human; infant; intravenous drug administration; major clinical study; male; motor performance; Pennsylvania; phase 1 clinical trial; phase 3 clinical trial; therapy effect; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
  onasemnogene abeparvovec (1922968-73-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L627648367
DOI
  10.1055/s00942716
FULL TEXT LINK
  http://dx.doi.org/10.1055/s00942716
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14391899&id=doi:10.1055%2Fs00942716&atitle=Early+diagnosis+and+speed+to+effect+in+spinal+muscular+atrophy+type+1+%28SMA-1%29&stitle=Neuropediatrics&title=Neuropediatrics&volume=50&issue=&spage=&epage=&aulast=Dabbous&aufirst=O.&auinit=O.&aufull=Dabbous+O.&coden=&isbn=&pages=-&date=2019&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 20
TITLE
  Abdominal functional electrical stimulation to augment respiratory function 
in spinal cord injury
AUTHOR NAMES
  McCaughey E.J.; Butler J.E.; McBain R.A.; Boswell-Ruys C.L.; Hudson A.L.; Gandevia S.C.; Lee B.B.
AUTHOR ADDRESSES
  (McCaughey E.J.; Butler J.E.; McBain R.A.; Boswell-Ruys C.L.; Hudson A.L.; 
Gandevia S.C.; Lee B.B., guslogie@gmail.com) Neuroscience Research 
Australia, Randwick, Australia.
(McCaughey E.J.; Butler J.E.; McBain R.A.; Boswell-Ruys C.L.; Hudson A.L.; 
Gandevia S.C.; Lee B.B., guslogie@gmail.com) School of Medical Sciences, 
University of New South Wales, Kensington, Australia.
(McBain R.A.; Boswell-Ruys C.L.; Gandevia S.C.; Lee B.B., 
guslogie@gmail.com) Prince of Wales Hospital, Spinal Injuries Unit, 
Randwick, Australia.
CORRESPONDENCE ADDRESS
  B.B. Lee, Neuroscience Research Australia, Randwick, Australia. Email: 
guslogie@gmail.com
AiP/IP ENTRY DATE
  2019-06-21
FULL RECORD ENTRY DATE
  2019-06-26
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2019) 25:2 (105-111). Date of 
Publication: 1 Mar 2019
VOLUME
  25
ISSUE
  2
FIRST PAGE
  105
LAST PAGE
  111
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  1945-5763 (electronic)
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc.
ABSTRACT
  Background: Functional electrical stimulation (FES) is the application of 
electrical pulses to a nerve to achieve a functional muscle contraction. 
Surface electrical stimulation of the nerves that innervate the abdominal 
muscles, termed abdominal FES, can cause the abdominal muscles to contract, 
even when paralysed after spinal cord injury. As the abdominal muscles are 
the major expiratory muscles, and commonly partially or completely paralysed 
in tetraplegia, abdominal FES offers a promising method of improving 
respiratory function for this patient group. Objective: The aim of the 
article is to provide readers with a better understanding of how abdominal 
FES can be used to improve the health of the spinal cord–injured population. 
Methods: A narrative review of the abdominal FES literature was performed. 
Results: Abdominal FES can achieve an immediate effective cough in patients 
with tetraplegia, while the repeated application over 6 weeks of abdominal 
FES can improve unassisted respiratory function. Ventilator duration and 
tracheostomy cannulation time can also be reduced with repeated abdominal 
FES. Conclusion: Abdominal FES is a noninvasive method to achieve functional 
improvements in cough and respiratory function in acute and chronically 
injured people with tetraplegia. Potential practical outcomes of this 
include reduced ventilation duration, assisted tracheostomy decannulation, 
and a reduction in respiratory complications. All of these outcomes can 
contribute to reduced morbidity and mortality, improved quality of life, and 
significant potential cost savings for local health care providers.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdomen; functional electrical stimulation; respiratory function; spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  article; cannulation; coughing; health status; human; lung ventilation; quadriplegia; tracheostomy; ventilator weaning; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Gastroenterology (48)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  31068742 (http://www.ncbi.nlm.nih.gov/pubmed/31068742)
PUI
  L2002107089
DOI
  10.1310/sci2502-105
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci2502-105
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19455763&id=doi:10.1310%2Fsci2502-105&atitle=Abdominal+functional+electrical+stimulation+to+augment+respiratory+function+in+spinal+cord+injury&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=25&issue=2&spage=105&epage=111&aulast=McCaughey&aufirst=E.J.&auinit=E.J.&aufull=McCaughey+E.J.&coden=TSIRF&isbn=&pages=105-111&date=2019&auinit1=E&auinitm=J
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 21
TITLE
  Parents’ Experiences of Information and Decision Making in the Care of Their 
Child With Severe Spinal Muscular Atrophy: A Population Survey
AUTHOR NAMES
  Beernaert K.; Lövgren M.; Jeppesen J.; Werlauff U.; Rahbek J.; Sejersen T.; Kreicbergs U.
AUTHOR ADDRESSES
  (Beernaert K., kim.beernaert@ugent.be) End-of-Life Care Research Group, 
Ghent University & Vrije Universtiteit Brussel (VUB), Ghent, Belgium.
(Lövgren M.; Kreicbergs U.) Ersta Sköndal Bräcke University College, 
Department of Health Care Sciences, Palliative Research Centre, Stockholm, 
Sweden.
(Lövgren M.; Kreicbergs U.) Department of Women’s and Children’s Health, 
Paediatric Oncology and Haematology, Childhood Cancer Research Unit, 
Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
(Jeppesen J.; Werlauff U.; Rahbek J.) National Rehabilitation Centre for 
Neuromuscular Diseases, Aarhus, Denmark.
(Sejersen T.) Department of Women’s and Children’s Health, Paediatric 
Neurology, Karolinska Institutet, Karolinska University Hospital, Astrid 
Lindgren Children’s Hospital, Stockholm, Sweden.
CORRESPONDENCE ADDRESS
  K. Beernaert, End-of-Life Care Research Group, Ghent University & Vrije 
Universtiteit Brussel (VUB), Ghent, Belgium. Email: kim.beernaert@ugent.be
AiP/IP ENTRY DATE
  2019-02-01
FULL RECORD ENTRY DATE
  2019-02-22
SOURCE
  Journal of Child Neurology (2019) 34:4 (210-215). Date of Publication: 1 Mar 
2019
VOLUME
  34
ISSUE
  4
FIRST PAGE
  210
LAST PAGE
  215
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  1708-8283 (electronic)
  0883-0738
BOOK PUBLISHER
  SAGE Publications Inc., claims@sagepub.com
ABSTRACT
  Objective: This study aims to assess the experiences and wishes of parents 
of children with severe spinal muscular atrophy regarding information and 
decision-making throughout the course of the illness. Study Design: A full 
population survey, conducted in 2015, among parents of children with severe 
spinal muscular atrophy who were born in Denmark between January 1, 2003, 
and December 31, 2013. We used a study-specific questionnaire with items 
about experiences and wishes concerning the provision of information about 
diagnosis, treatment, and end-of-life care. Results: Among the 47 parents 
that were identified, 34 parents of 21 children participated. Eleven of them 
were nonbereaved and 23 were bereaved parents. All parents stated that 
health care staff did not take any decisions without informing them. A 
proportion of parents indicated that they were not informed about what 
spinal muscular atrophy entails (32%), possible treatment options (18%), or 
the fact that their child would have a short life (26%) or that death was 
imminent (57%). Most of the bereaved parents who had wishes concerning how 
and where their child would pass away had their wishes fulfilled. 
Conclusions: The study showed that health care staff did not take treatment 
decisions without parents being informed. However, there is room for 
improvement concerning information about what spinal muscular atrophy 
entails, treatment options, and prognosis. Possibilities of palliative care 
and advance care planning should be investigated for these parents, their 
child, and health care staff.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  adult; advance care planning; article; assisted ventilation; child care; decision making; female; health survey; human; human experiment; male; middle aged; normal human; palliative therapy; parent; patient information; perception; personal experience; physician; priority journal; prognosis; structured questionnaire; terminal care; total quality management; tracheostomy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L626128688
DOI
  10.1177/0883073818822900
FULL TEXT LINK
  http://dx.doi.org/10.1177/0883073818822900
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17088283&id=doi:10.1177%2F0883073818822900&atitle=Parents%E2%80%99+Experiences+of+Information+and+Decision+Making+in+the+Care+of+Their+Child+With+Severe+Spinal+Muscular+Atrophy%3A+A+Population+Survey&stitle=J.+Child+Neurol.&title=Journal+of+Child+Neurology&volume=34&issue=4&spage=210&epage=215&aulast=Beernaert&aufirst=Kim&auinit=K.&aufull=Beernaert+K.&coden=JOCNE&isbn=&pages=210-215&date=2019&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 22
TITLE
  Trauma Airway Management: Induction Agents, Rapid Versus Slower Sequence 
Intubations, and Special Considerations
AUTHOR NAMES
  Estime S.R.; Kuza C.M.
AUTHOR ADDRESSES
  (Estime S.R., sestime@gmail.com) Department of Anesthesiology and Critical 
Care, University of Chicago Medicine, 5841 South Maryland Avenue, MC-4028, 
Chicago, United States.
(Kuza C.M.) Department of Anesthesiology and Critical Care, Keck School of 
Medicine, University of Southern California, 1520 San Pablo Street, Suite 
3451, Los Angeles, United States.
CORRESPONDENCE ADDRESS
  S.R. Estime, University of Chicago Medicine, 5841 South Maryland Avenue, 
MC-4028, Chicago, United States. Email: sestime@gmail.com
AiP/IP ENTRY DATE
  2018-12-24
FULL RECORD ENTRY DATE
  2019-02-06
SOURCE
  Anesthesiology Clinics (2019) 37:1 (33-50). Date of Publication: 1 Mar 2019
VOLUME
  37
ISSUE
  1
FIRST PAGE
  33
LAST PAGE
  50
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  2210-3538 (electronic)
  1932-2275
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Trauma patients who require intubation are at higher risk for aspiration, 
agitation/combativeness, distorted anatomy, hemodynamic instability, an 
unstable cervical spine, and complicated injuries. Although rapid-sequence 
intubation is the most common technique in trauma, slow-sequence intubation 
may reduce the risk for failed intubation and cardiovascular collapse. 
Providers often choose plans with which they are most comfortable. However, 
developing a flexible team-based approach, through recognition of 
complicating factors in trauma patients, improves airway management success.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  anesthetic agent; 
EMTREE DRUG INDEX TERMS
  benzodiazepine derivative; etomidate; ketamine; midazolam; neuromuscular blocking agent; propofol; rocuronium; sugammadex; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia induction; injury; intubation; respiration control; 
EMTREE MEDICAL INDEX TERMS
  acid aspiration; blunt trauma; breathing; cervical spine injury (therapy); emergency care; face fracture (therapy); face injury (therapy); fiberoptic bronchoscopy; hemodynamics; hemoptysis; human; intracranial hypertension (therapy); laryngeal mask; larynx injury (therapy); lung hemorrhage (therapy); maxillofacial injury (therapy); medical decision making; patient compliance; review; risk reduction; sedation; shock; spine instability; submental intubation; trachea injury (therapy); tracheostomy; traumatic brain injury (therapy); treatment indication; 
CAS REGISTRY NUMBERS
  etomidate (15301-65-2, 33125-97-2, 51919-80-3)
  ketamine (1867-66-9, 6740-88-1, 81771-21-3)
  midazolam (59467-70-8)
  propofol (2078-54-8)
  rocuronium (119302-91-9)
  sugammadex (343306-79-6, 343306-71-8)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30711232 (http://www.ncbi.nlm.nih.gov/pubmed/30711232)
PUI
  L2001387013
DOI
  10.1016/j.anclin.2018.09.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.anclin.2018.09.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22103538&id=doi:10.1016%2Fj.anclin.2018.09.002&atitle=Trauma+Airway+Management%3A+Induction+Agents%2C+Rapid+Versus+Slower+Sequence+Intubations%2C+and+Special+Considerations&stitle=Anesthesiol.+Clin.&title=Anesthesiology+Clinics&volume=37&issue=1&spage=33&epage=50&aulast=Estime&aufirst=Stephen+R.&auinit=S.R.&aufull=Estime+S.R.&coden=&isbn=&pages=33-50&date=2019&auinit1=S&auinitm=R
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 23
TITLE
  Pre-Nusinersen Hospitalization Costs of Children With Spinal Muscular 
Atrophy
AUTHOR NAMES
  Lee M.; França U.L.; Graham R.J.; McManus M.L.
AUTHOR ADDRESSES
  (Lee M., Michael.Lee@childrens.harvard.edu) Division of Emergency Medicine, 
Boston Children's Hospital, Boston, United States.
(França U.L.; Graham R.J.; McManus M.L.) Division of Critical Care, 
Department of Anesthesiology, Critical Care and Pain Medicine, Boston 
Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, 
United States.
CORRESPONDENCE ADDRESS
  M. Lee, Boston Children's Hospital, 300 Longwood Ave. BCH 3066, Boston, 
United States. Email: Michael.Lee@childrens.harvard.edu
AiP/IP ENTRY DATE
  2018-12-28
FULL RECORD ENTRY DATE
  2019-03-05
SOURCE
  Pediatric Neurology (2019) 92 (3-5). Date of Publication: 1 Mar 2019
VOLUME
  92
FIRST PAGE
  3
LAST PAGE
  5
DATE OF PUBLICATION
  1 Mar 2019
ISSN
  1873-5150 (electronic)
  0887-8994
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen (drug therapy, pharmacoeconomics); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health care cost; hospitalization; spinal muscular atrophy (disease management, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  article; child; cohort analysis; hospital admission; hospital care; hospital patient; human; ICD-9; length of stay; major clinical study; priority journal; retrospective study; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  30591237 (http://www.ncbi.nlm.nih.gov/pubmed/30591237)
PUI
  L2001406214
DOI
  10.1016/j.pediatrneurol.2018.11.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18735150&id=doi:10.1016%2Fj.pediatrneurol.2018.11.002&atitle=Pre-Nusinersen+Hospitalization+Costs+of+Children+With+Spinal+Muscular+Atrophy&stitle=Pediatr.+Neurol.&title=Pediatric+Neurology&volume=92&issue=&spage=3&epage=5&aulast=Lee&aufirst=Michael&auinit=M.&aufull=Lee+M.&coden=PNEUE&isbn=&pages=3-5&date=2019&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 24
TITLE
  Atlanto-occipital dislocation in a patient presenting with out-of-hospital 
cardiac arrest: A case report and literature review 11 Medical and Health 
Sciences 1103 Clinical Sciences
AUTHOR NAMES
  Rief M.; Zoidl P.; Zajic P.; Heschl S.; Orlob S.; Silbernagel G.; Metnitz P.; Puchwein P.; Prause G.
AUTHOR ADDRESSES
  (Rief M., martin.rief@medunigraz.at; Zoidl P., philipp.zoidl@medunigraz.at; 
Zajic P., paul.zajic@medunigraz.at; Orlob S., simon.orlob@medunigraz.at; 
Metnitz P., philipp.metnitz@medunigraz.at; Prause G., 
gerhard.prause@medunigraz.at) Division of General Anaesthesiology, Emergency 
and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 5, 
Graz, Austria.
(Rief M., martin.rief@medunigraz.at; Zoidl P., philipp.zoidl@medunigraz.at; 
Zajic P., paul.zajic@medunigraz.at; Heschl S., stefan.heschl@medunigraz.at; 
Orlob S., simon.orlob@medunigraz.at; Metnitz P., 
philipp.metnitz@medunigraz.at; Prause G., gerhard.prause@medunigraz.at) 
Department of Anaesthesiology, Medical University of Graz, Auenbruggerplatz 
5, Graz, Austria.
(Heschl S., stefan.heschl@medunigraz.at) Division of Cardiac, Thoracic and 
Vascular Anaesthesiology, Medical University of Graz, Auenbruggerplatz 5, 
Graz, Austria.
(Silbernagel G., guenther.silbernagel@medunigraz.at) Division of Angiology, 
Department of Internal Medicine, Medical University of Graz, 
Auenbruggerplatz 15, Graz, Austria.
(Puchwein P., paul.puchwein@medunigraz.at) Department of Orthopedics and 
Trauma Surgery, Medical University of Graz, Auenbruggerplatz 5, Graz, 
Austria.
CORRESPONDENCE ADDRESS
  M. Rief, Division of General Anaesthesiology, Emergency and Intensive Care 
Medicine, Medical University of Graz, Auenbruggerplatz 5, Graz, Austria. 
Email: martin.rief@medunigraz.at
AiP/IP ENTRY DATE
  2019-04-01
FULL RECORD ENTRY DATE
  2019-04-04
SOURCE
  Journal of Medical Case Reports (2019) 13:1 Article Number: 44. Date of 
Publication: 26 Feb 2019
VOLUME
  13
ISSUE
  1
DATE OF PUBLICATION
  26 Feb 2019
ISSN
  1752-1947 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Background: Atlanto-occipital dislocation is a rare and severe injury of the 
upper spine associated with a very poor prognosis. Case presentation: We 
report the case of a 59-year-old European man who suffered from 
out-of-hospital cardiac arrest following a motor vehicle accident. 
Cardiopulmonary resuscitation was initiated immediately by bystanders and 
continued by emergency medical services. After 30 minutes of cardiopulmonary 
resuscitation with a total of five shocks following initial ventricular 
fibrillation, return of spontaneous circulation was achieved. An 
electrocardiogram recorded after return of spontaneous circulation at the 
scene showed signs of myocardial ischemia as a possible cause for the 
cardiac arrest. No visible signs of injury were found. He was transferred to 
the regional academic trauma center. Following an extended diagnostic and 
therapeutic workup in the emergency room, including extended focused 
assessment with sonography for trauma ultrasound, whole-body computed 
tomography, and magnetic resonance imaging (of his head and neck), a 
diagnosis of major trauma (atlanto-occipital dislocation, bilateral serial 
rip fractures and pneumothoraces, several severe intracranial bleedings, and 
other injuries) was made. An unfavorable outcome was initially expected due 
to suspected tetraplegia and his inability to breathe following 
atlanto-occipital dislocation. Contrary to initial prognostication, after 22 
days of intensive care treatment and four surgical interventions (halo 
fixation, tracheostomy, intracranial pressure probe, chest drains) he was 
awake and oriented, spontaneously breathing, and moving his arms and legs. 
Six weeks after the event he was able to walk without aid. After 2 months of 
clinical treatment he was able to manage all the activities of daily life on 
his own. It remains unclear, whether cardiac arrest due to a cardiac cause 
resulted in complete atony of the paravertebral muscles and caused this 
extremely severe lesion (atlanto-occipital dislocation) or whether cardiac 
arrest was caused by apnea due the paraplegia following the spinal injury of 
the trauma. Conclusions: A plausible cause for the trauma was myocardial 
infarction which led to the car accident and the major trauma in relation to 
the obviously minor trauma mechanism. With this case report we aim to 
familiarize clinicians with the mechanism of injury that will assist in the 
diagnosis of atlanto-occipital dislocation. Furthermore, we seek to 
emphasize that patients presenting with electrocardiographic signs of 
myocardial ischemia after high-energy trauma should primarily be transported 
to a trauma facility in a percutaneous coronary intervention-capable center 
rather than the catheterization laboratory directly.
EMTREE DRUG INDEX TERMS
  catecholamine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlanto occipital dislocation (diagnosis, surgery); out of hospital cardiac arrest (therapy); vertebra dislocation (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  acute coronary syndrome (diagnosis); adult; article; artificial ventilation; automated external defibrillator; bradycardia (therapy); case report; clinical article; computer assisted tomography; coronary angiography; electrocardiogram; emergency health service; European; follow up; heart muscle ischemia; heart pacing; heart ventricle fibrillation; heart ventricle tachycardia (diagnosis); human; implantable cardioverter defibrillator; intensive care unit; ischemic cardiomyopathy (diagnosis); ischemic heart disease; left anterior descending coronary artery; male; medical history; middle aged; neurorehabilitation; nuclear magnetic resonance imaging; outcome assessment; percutaneous coronary intervention; priority journal; prognosis; respiratory tract intubation; resuscitation; return of spontaneous circulation; scapula fracture; teleconsultation; traffic accident; unconsciousness; 
DEVICE TRADE NAMES
  LifeVest
EMBASE CLASSIFICATIONS
  Radiology (14)
  Public Health, Social Medicine and Epidemiology (17)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Rehabilitation and Physical Medicine (19)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30803441 (http://www.ncbi.nlm.nih.gov/pubmed/30803441)
PUI
  L626499516
DOI
  10.1186/s13256-018-1926-2
FULL TEXT LINK
  http://dx.doi.org/10.1186/s13256-018-1926-2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17521947&id=doi:10.1186%2Fs13256-018-1926-2&atitle=Atlanto-occipital+dislocation+in+a+patient+presenting+with+out-of-hospital+cardiac+arrest%3A+A+case+report+and+literature+review+11+Medical+and+Health+Sciences+1103+Clinical+Sciences&stitle=J.+Med.+Case+Rep.&title=Journal+of+Medical+Case+Reports&volume=13&issue=1&spage=&epage=&aulast=Rief&aufirst=Martin&auinit=M.&aufull=Rief+M.&coden=&isbn=&pages=-&date=2019&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 25
TITLE
  Spinal muscular atrophy with respiratory distress type 1: A multicenter 
retrospective study
AUTHOR NAMES
  Viguier A.; Lauwers-Cances V.; Cintas P.; Manel V.; Peudenier S.; Desguerre I.; Quijano-Roy S.; Vanhulle C.; Fradin M.; Isapof A.; Jokic M.; Mathieu-Dramard M.; Dieterich K.; Petit F.; Magdelaine C.; Giuliano F.; Gras D.; Haye D.; Nizon M.; Magen M.; Bieth E.; Cances C.
AUTHOR ADDRESSES
  (Viguier A., agnes.viguier@free.fr; Cances C.) Department of 
Neuropediatrics, Children's Hospital of the University of Toulouse, 330 
Great Britain Avenue, Toulouse, France.
(Lauwers-Cances V.) Faculty of Medicine, Epidemiology Department, University 
Hospital of Toulouse, 37 Allées Jules Guesde, Toulouse, France.
(Cintas P.) Neurology Department, University Hospital of Toulouse, 330 Great 
Britain Avenue, Toulouse, France.
(Manel V.) Department of Neuropediatrics, Woman-Mother-Child Hospital, 
University Hospitals of Lyon, 59 Boulevard Pinel, Bron, France.
(Peudenier S.) Division of Pediatric Neurology, Department of Pediatrics, 
Brest Regional University Hospital, 2 Avenue Foch, Brest, France.
(Desguerre I.) Department of Neuropediatrics, Necker Enfants-Malades 
Hospital, 149 Rue de Sèvres, Cedex 15, Paris, France.
(Quijano-Roy S.) Garches Neuromuscular Reference Center (GNMH), APHP Raymond 
Poincare University Hospital (UVSQ), Garches, France.
(Vanhulle C.) Department of Neonatal Pediatrics and Intensive Care, 
Neuropediatrics, Rehabilitation Centre, Rouen University Hospital, Rouen, 
France.
(Fradin M.) Unit of Medical Genetics, University Hospital of Rennes, 16 
Boulevard de Bulgarie, Cedex 2, Rennes, France.
(Isapof A.) GRC ConCer-LD, UPMC Univ Paris 06, & Department Child Neurology 
and Reference Center for Neuromuscular Diseases “Nord/Est/Ile-de-France”, 
Sorbonne Universités, FILNEMUS, Paris, France.
(Jokic M.) Pediatric Intensive Care Department, University Hospital of Caen, 
Avenue Côte-de-Nacre, Caen, France.
(Mathieu-Dramard M.) Unit of Medical Genetics, University Hospital of 
Amiens, site-sud, Amiens CEDEX1, France.
(Dieterich K.) Unit of Medical Genetics, Grenoble Alpes University Hospital, 
Quai Yermoloff, La Tronche, France.
(Petit F.) CHU Lille, Clinique de Génétique Guy Fontaine, Lille, France.
(Magdelaine C.) Unit of Medical Genetics, University Hospital of Limoges, 2 
Avenue Martin Luther King, Limoges, France.
(Giuliano F.) Unit of Medical Genetics, University Hospital of Nice, 
L'Archet 2 Hospital, 151 Route Saint-Antoine de Ginestière BP 3079, Cedex 3, 
Nice, France.
(Gras D.) Department of Neuropediatrics, Robert Debré University Hospital, 
48 Bd Sérurier, Paris, France.
(Haye D.) Unit of Medical Genetics, Robert Debré University Hospital, 48 Bd 
Sérurier, Paris, France.
(Nizon M.; Magen M.) Unit of Medical Genetics, Necker Enfants-Malades 
Hospital, 149 Rue de Sèvres, Cedex 15, Paris, France.
(Bieth E.) Unit of Medical Genetics, Hospital of the University of Toulouse, 
330 Great Britain Avenue, Toulouse, France.
CORRESPONDENCE ADDRESS
  A. Viguier, Department of Neuropediatrics, Children's Hospital of the 
University of Toulouse, 330 Great Britain Avenue, Toulouse, France. Email: 
agnes.viguier@free.fr
AiP/IP ENTRY DATE
  2019-01-01
FULL RECORD ENTRY DATE
  2019-03-05
SOURCE
  Neuromuscular Disorders (2019) 29:2 (114-126). Date of Publication: 1 Feb 
2019
VOLUME
  29
ISSUE
  2
FIRST PAGE
  114
LAST PAGE
  126
DATE OF PUBLICATION
  1 Feb 2019
ISSN
  1873-2364 (electronic)
  0960-8966
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a rare 
autosomal recessive neuromuscular disorder characterized by progressive 
motor and respiratory decline during the first year of life. Early and 
late-onset cases have recently been reported, although not meeting the 
established diagnostic criteria, these cases have been genotyped. We thus 
conducted a national multicenter observational retrospective study to 
determine the prognosis of children with SMARD1 according to their 
phenotype. We recorded all known French pediatric cases with mutations 
identified on the immunoglobulin μ-binding protein 2 gene and the presence 
of respiratory symptoms. Thirty centers provided 22 observations. A 
diaphragmatic palsy was diagnosed 1.5 months (p = 0.02) after first 
respiratory symptoms, and hypotonia preceded areflexia by 4 months (p = 
0.02). Early onset of symptoms leading to specialist consultation before the 
age of 3 months was associated with a significantly worse prognosis (p < 
0.01). Among the 6 patients who were still alive, all were tracheostomized. 
Only one case survived beyond 2 years without artificial ventilation. The 
remaining patients died at a median age of 7 months. Our results may help 
pediatricians to provide medical information to parents and improve the 
decision-making process of setting up life support.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neonatal respiratory distress syndrome (surgery); Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  areflexia; article; artificial ventilation; clinical article; clinical decision making; consultation; diaphragm paralysis (diagnosis); disease association; female; Frenchman; gene; gene mutation; genetic identification; human; immunoglobulin mu binding protein 2 gene; infant; infant mortality; long term care; male; medical information; multicenter study; muscle hypotonia; observational study; onset age; pediatrician; priority journal; prognosis; respiratory tract disease; retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30598237 (http://www.ncbi.nlm.nih.gov/pubmed/30598237)
PUI
  L2001417448
DOI
  10.1016/j.nmd.2018.10.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nmd.2018.10.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18732364&id=doi:10.1016%2Fj.nmd.2018.10.002&atitle=Spinal+muscular+atrophy+with+respiratory+distress+type+1%3A+A+multicenter+retrospective+study&stitle=Neuromuscular+Disord.&title=Neuromuscular+Disorders&volume=29&issue=2&spage=114&epage=126&aulast=Viguier&aufirst=Agn%C3%A8s&auinit=A.&aufull=Viguier+A.&coden=NEDIE&isbn=&pages=114-126&date=2019&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 26
TITLE
  Is the Posterior-Only Approach Sufficient for Treating Cervical Spine 
Metastases? The Evidence from a Case Series
AUTHOR NAMES
  Gallazzi E.; Cannavò L.; Perrucchini G.G.; Morelli I.; Luzzati A.D.; Zoccali C.; Scotto G.
AUTHOR ADDRESSES
  (Gallazzi E., enrico.gallazzi@gmail.com; Cannavò L.; Perrucchini G.G.; 
Morelli I.; Luzzati A.D.; Scotto G.) Department of Orthopaedic Oncology and 
Spinal Reconstructive Surgery, I.R.C.C.S. Istituto Ortopedico Galeazzi, 
Milano, Italy.
(Zoccali C.) Oncological Orthopedics, Regina Elena National Cancer 
Institute, Rome, Italy.
CORRESPONDENCE ADDRESS
  E. Gallazzi, Department of Orthopaedic Oncology and Spinal Reconstructive 
Surgery, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy. Email: 
enrico.gallazzi@gmail.com
AiP/IP ENTRY DATE
  2018-12-03
FULL RECORD ENTRY DATE
  2019-02-28
SOURCE
  World Neurosurgery (2019) 122 (e783-e789). Date of Publication: 1 Feb 2019
VOLUME
  122
FIRST PAGE
  e783
LAST PAGE
  e789
DATE OF PUBLICATION
  1 Feb 2019
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Objectives: Few studies have evaluated surgical options in the treatment of 
cervical metastatic disease. The aim of this study is to report the surgical 
outcomes of patients treated with the posterior-only approach for metastatic 
cervical disease. Methods: In this retrospective analysis, all cases treated 
in our institution from 2009 to 2017 were reviewed. Six (20%) patients had 
intracompartimental lesions (Tomita 1–3), whereas 24 (80%) patients had 
extracompartimental lesions (Tomita 4–7), with extensive anterior column 
involvement. All patients were surgically treated with laminectomy and 
posterior stabilization. Pain and neurologic function were evaluated before 
and after surgery. Results: Thirty patients were included (15 female, 15 
male), with a mean age of 60.6 ± 11.56 years (range 35–82 years). Lesions 
were located in 7 patients (23.3%) in the upper cervical spine and in 14 
patients (46.6%) and in 9 patients (30,1%) in the mid-cervical and in the 
cervicothoracic junction, respectively. At a mean follow up of 13.7 ± 14.8 
months, 15 (50%) patients died from their disease. Pain decreased in all 
patients after surgery, (preoperative NRS 5.57 ± 1.81 postoperative Numeric 
Rating Scale of 2.1 ± 1.0, P < 0.00001). Two patients (6.7%) had significant 
neurologic worsening after surgery. Two (6.9%) patients had surgical-site 
infection that required reintervention. No mechanical failures were 
observed. Conclusions: In our series, posterior-only fixation provided 
postoperative pain relief and achieve spinal stability, ultimately improving 
the quality of life. In conclusion, posterior-approach decompression and 
stabilization is a safe and feasible procedure in patients with neurologic 
or mechanical instability for cervical spine metastasis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; posterior spine fusion; spine metastasis (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cancer mortality; cancer patient; cancer survival; clinical article; clinical outcome; computer assisted tomography; female; follow up; general condition deterioration; hospital mortality; human; laminectomy; lung embolism; male; middle aged; neurological complication; nuclear magnetic resonance imaging; numeric rating scale; peroperative complication; postoperative pain; preoperative evaluation; retrospective study; spine stabilization; surgical approach; surgical infection; thoracic spine; tracheostomy; wound dehiscence; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30391608 (http://www.ncbi.nlm.nih.gov/pubmed/30391608)
PUI
  L2001326052
DOI
  10.1016/j.wneu.2018.10.147
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2018.10.147
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2018.10.147&atitle=Is+the+Posterior-Only+Approach+Sufficient+for+Treating+Cervical+Spine+Metastases%3F+The+Evidence+from+a+Case+Series&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=122&issue=&spage=e783&epage=e789&aulast=Gallazzi&aufirst=Enrico&auinit=E.&aufull=Gallazzi+E.&coden=&isbn=&pages=e783-e789&date=2019&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 27
TITLE
  Endoscopic-assisted resection of anterior foramen magnum meningiomas through 
a midline suboccipital subtonsillar approach
AUTHOR NAMES
  Roser F.; Rigante L.; El-Hammady S.
AUTHOR ADDRESSES
  (Roser F.; Rigante L.; El-Hammady S.) Cleveland Clinic Abu Dhabi, Abu Dhabi, 
United Arab Emirates.
CORRESPONDENCE ADDRESS
  F. Roser, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Journal of Neurological Surgery, Part B: Skull Base (2019) 80 Supplement 1. 
Date of Publication: 1 Feb 2019
VOLUME
  80
DATE OF PUBLICATION
  1 Feb 2019
CONFERENCE NAME
  29th Annual Meeting North American Skull Base Society
CONFERENCE LOCATION
  Orlando, FL, United States
CONFERENCE DATE
  2019-02-15 to 2019-02-17
ISSN
  2193-6331
BOOK PUBLISHER
  Thieme Medical Publishers, Inc.
ABSTRACT
  Objectives: To demonstrate the feasibility of safe resection of anterior 
foramen magnum meningiomas through an endoscopic-assisted posterior midline 
suboccipital subtonsillar approach. Design: Illustrating the surgical steps 
and outcome of this approach. Setting: Evidence of CSF cleft between the 
tumor and brainstem/spinal cord on T2Wi MRI and homogeneous contrast 
enhancement. Semi-sitting positioning with extensive electrophysiological 
neuromonitoring and transesophageal echocardiogram. Preoperative tracheotomy 
can be considered in cases of preoperative dysphagia/respiratory distress. A 
standard midline incision with bilateral suboccipital craniotomy and 
C1-laminotomy is performed. After partial resection and elevation of the 
tonsils, tumor is debulked unilaterally around the lower cranial nerves and 
the vertebral artery, devascularized from the clival dura, and then 
dissected from the brainstem. Endoscopic-assisted removal of its anterior 
portion follows. The same procedure is repeated from the opposite site for 
the contralateral portion, before approaching the purely anterior part with 
endoscope assistance. Participants: Four consecutive patients. Main Outcome 
Measures: Grade of tumor resection and outcome (mRS). Results: Clinical 
outcome and grade of resection are comparable to other series of patient 
treated with other foramen magnum approaches. Conclusion: Anterior foramen 
magnum meningiomas can be safely removed through this relatively faster 
midline approach with bilateral exposure of lower CNs and vertebral arteries 
and lower approach-related morbidity (no condyle drilling). The surgical 
corridor is created by the tumor during debulking reducing need for brain 
retraction and the removal of the anterior dural attachment coagulated under 
the microscope is verified and completed endoscopically with pituitary 
curettes (Simpson II).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  foramen magnum; meningioma; 
EMTREE MEDICAL INDEX TERMS
  adult; brain stem tumor; cancer surgery; case report; clinical article; clinical outcome; conference abstract; contrast enhancement; cranial nerve; craniotomy; curette; drill; dura mater; dysphagia; echocardiography; endoscope; female; human; incision; male; microscope; morbidity; neuromonitoring; nuclear magnetic resonance imaging; Rankin scale; respiratory distress; spinal cord; surgery; tonsil; tracheostomy; vertebral artery; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L627318803
DOI
  10.1055/s-0039-1679460
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0039-1679460
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21936331&id=doi:10.1055%2Fs-0039-1679460&atitle=Endoscopic-assisted+resection+of+anterior+foramen+magnum+meningiomas+through+a+midline+suboccipital+subtonsillar+approach&stitle=J.+Neurol.+Surg.+Part+B+Skull+Base&title=Journal+of+Neurological+Surgery%2C+Part+B%3A+Skull+Base&volume=80&issue=&spage=&epage=&aulast=Roser&aufirst=Florian&auinit=F.&aufull=Roser+F.&coden=&isbn=&pages=-&date=2019&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 28
TITLE
  Efficacy of new intermittent abdominal pressure ventilator for post-ischemic 
cervical myelopathy ventilatory insufficiency
AUTHOR NAMES
  Banfi P.I.; Volpato E.; Bach J.R.
AUTHOR ADDRESSES
  (Banfi P.I.; Volpato E., eleonora.volpato@unicatt.it) IRCCS Santa Maria 
Nascente, Fondazione Don Carlo Gnocchi, Milan, Italy.
(Volpato E., eleonora.volpato@unicatt.it) Department of Psychology, 
Università Cattolica Del Sacro Cuore, Milan, Italy.
(Bach J.R.) Department of Physical Medicine and Rehabilitation, Rutgers 
University, New Jersey Medical School, Newark, United States.
CORRESPONDENCE ADDRESS
  E. Volpato, IRCCS Santa Maria Nascente, Fondazione Don Carlo Gnocchi, Milan, 
Italy. Email: eleonora.volpato@unicatt.it
AiP/IP ENTRY DATE
  2019-02-08
FULL RECORD ENTRY DATE
  2019-02-13
SOURCE
  Multidisciplinary Respiratory Medicine (2019) 14:1 Article Number: 4. Date 
of Publication: 28 Jan 2019
VOLUME
  14
ISSUE
  1
DATE OF PUBLICATION
  28 Jan 2019
ISSN
  2049-6958 (electronic)
  1828-695X
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Non-invasive ventilation (NIV) is the treatment of choice for patients 
symptomatic for respiratory muscle dysfunction. It can normalize gas 
exchange and provide up to continuous non-invasive ventilator support (CNVS) 
as an alternative to intubation and tracheotomy. It is usually provided via 
non-invasive facial interfaces or mouthpieces, but these can be 
uncomfortable and uncosmetic. The intermittent abdominal pressure ventilator 
(IAPV) has been used for diurnal ventilatory support since 1938 but has been 
off the market since about 1990. Now, however, with greater emphasis on 
non-invasive management, a new IAPV is available. A patient with chronic 
ventilatory insufficiency post-ischemic cervical myelopathy, dependent on 
sleep NVS since 2003, developed symptomatic daytime hypercapnia for which he 
also used diurnal NVS via nasal pillows. However, he preferred not having to 
use facial interfaces. When not using diurnal NVS he was becoming dyspnoeic. 
Diurnal use of an IAPV was introduced. Arterial blood gas analysis using the 
IAPV decreased his blood pH from 7.45 to 7.42, PaCO(2) from 58 to 37 mmHg, 
and improved PaO(2) from 62 to 92 mmHg. At discharge, the patient used the 
IAPV 8 h/day with improved mood and quality of life. Consequently, he 
returned to work as a painter.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical myelopathy; chronic respiratory failure (complication, therapy); intermittent abdominal pressure ventilation; intermittent positive pressure ventilation; pressure support ventilator; 
EMTREE MEDICAL INDEX TERMS
  Addenbroke Cognitive Examination Revised; adult; ambient air; article; blood carbon dioxide tension; blood oxygen tension; breathing rate; case report; clinical article; cognition assessment; dyspnea (therapy); European Quality of Life 5 Dimensions questionnaire; expiratory reserve volume; Hospital Anxiety and Depression Scale; human; hypercapnia (therapy); inspiratory capacity; intermittent abdominal pressure ventilator corset; LUNA DS; lung gas exchange; male; middle aged; Mini Mental State Examination; noninvasive ventilation; PBAir; portable equipment; positive end expiratory pressure; quality of life assessment; respiratory therapeutic device; therapy effect; tidal volume; World Health Organization Quality of Life Questionnaire Bref; 
DEVICE TRADE NAMES
  LUNA DS
  PBAir
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L626170263
DOI
  10.1186/s40248-019-0169-4
FULL TEXT LINK
  http://dx.doi.org/10.1186/s40248-019-0169-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20496958&id=doi:10.1186%2Fs40248-019-0169-4&atitle=Efficacy+of+new+intermittent+abdominal+pressure+ventilator+for+post-ischemic+cervical+myelopathy+ventilatory+insufficiency&stitle=Multidiscip.+Resp.+Med.&title=Multidisciplinary+Respiratory+Medicine&volume=14&issue=1&spage=&epage=&aulast=Banfi&aufirst=Paolo+I.&auinit=P.I.&aufull=Banfi+P.I.&coden=&isbn=&pages=-&date=2019&auinit1=P&auinitm=I
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 29
TITLE
  Management of airway obstruction due to diffuse idiopathic skeletal 
hyperostosis in the cervical spine: A case report and literature review
AUTHOR NAMES
  Yoshimatsu Y.; Tobino K.; Maeda K.; Kubota K.; Haruta Y.; Adachi H.; Abe T.; Masunaga T.; Sueyasu T.; Osaki T.
AUTHOR ADDRESSES
  (Yoshimatsu Y., yukitsukihana0105@gmail.com; Tobino K.; Masunaga T.; Sueyasu 
T.) Department of Respiratory Medicine, Iizuka Hospital, Japan.
(Tobino K.) Department of Respiratory Medicine, Juntendo University Graduate 
School of Medicine, Japan.
(Maeda K.; Kubota K.) Department of Orthopedic Surgery, Spinal Injuries 
Center, Japan.
(Haruta Y.) Department of Orthopedic Surgery, Iizuka Hospital, Japan.
(Adachi H.) Department of Intensive Care, Iizuka Hospital, Japan.
(Abe T.) Department of Gastroenterology, Iizuka Hospital, Japan.
(Osaki T.) Department of Thoracic Surgery, Iizuka Hospital, Japan.
CORRESPONDENCE ADDRESS
  Y. Yoshimatsu, Department of Respiratory Medicine, Iizuka Hospital, Japan. 
Email: yukitsukihana0105@gmail.com
AiP/IP ENTRY DATE
  2019-01-31
FULL RECORD ENTRY DATE
  2019-03-07
SOURCE
  Internal Medicine (2019) 58:2 (271-276). Date of Publication: 15 Jan 2019
VOLUME
  58
ISSUE
  2
FIRST PAGE
  271
LAST PAGE
  276
DATE OF PUBLICATION
  15 Jan 2019
ISSN
  1349-7235 (electronic)
  0918-2918
BOOK PUBLISHER
  Japanese Society of Internal Medicine
ABSTRACT
  Diffuse idiopathic skeletal hyperostosis (DISH) is a relatively common 
progressive noninflammatory entheses disease. Patients are often 
asymptomatic or are undiagnosed due to minor chronic symptoms. We herein 
report a rare case in which the primary symptom was sudden-onset upper 
airway obstruction due to exuberant osteophytosis in the cervical spine. 
Treatment was successful with careful airway management and surgical 
osteophyectomy. Most DISH cases in the literature with airway obstruction 
have been managed with tracheotomy. However, the safety and necessity of 
this approach remain questionable. We herein discuss the possibility of 
conservative management as a choice of airway control. Airway obstruction 
due to DISH may be underrecognized. This highlights the importance of 
including DISH in the differential diagnosis of airway obstruction. In 
addition, a detailed evaluation and personalized care for each individual 
case is essential.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; diffuse idiopathic skeletal hyperostosis (diagnosis); hyperostosis (diagnosis); upper respiratory tract obstruction; 
EMTREE MEDICAL INDEX TERMS
  aged; bronchoscopy; case report; clinical article; computer assisted tomography; conservative treatment; differential diagnosis; dysphagia; enteric feeding; gastrostomy; hospital discharge; human; lung edema; male; nasogastric tube; orthopedic surgery; osteophyectomy; parenteral nutrition; respiration control; review; tracheotomy; very elderly; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30146564 (http://www.ncbi.nlm.nih.gov/pubmed/30146564)
PUI
  L2001351818
DOI
  10.2169/internalmedicine.1071-18
FULL TEXT LINK
  http://dx.doi.org/10.2169/internalmedicine.1071-18
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13497235&id=doi:10.2169%2Finternalmedicine.1071-18&atitle=Management+of+airway+obstruction+due+to+diffuse+idiopathic+skeletal+hyperostosis+in+the+cervical+spine%3A+A+case+report+and+literature+review&stitle=Intern.+Med.&title=Internal+Medicine&volume=58&issue=2&spage=271&epage=276&aulast=Yoshimatsu&aufirst=Yuki&auinit=Y.&aufull=Yoshimatsu+Y.&coden=IEDIE&isbn=&pages=271-276&date=2019&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 30
TITLE
  Analysis of the risk factors for tracheostomy and decannulation after 
traumatic cervical spinal cord injury in an aging population
AUTHOR NAMES
  Higashi T.; Eguchi H.; Wakayama Y.; Sumi M.; Saito T.; Inaba Y.
AUTHOR ADDRESSES
  (Higashi T., higashi@yokohama-cu.ac.jp; Eguchi H.; Wakayama Y.; Sumi M.; 
Saito T.; Inaba Y.) Department of Orthopaedic Surgery, Yokohama City 
University School of Medicine, Yokohama, Japan.
(Higashi T., higashi@yokohama-cu.ac.jp) Yokohama City University Medical 
Center, 4-57 Urafunecho, Minami-ku, Japan.
CORRESPONDENCE ADDRESS
  T. Higashi, Department of Orthopaedic Surgery, Yokohama City University 
School of Medicine, Yokohama, Japan. Email: higashi@yokohama-cu.ac.jp
AiP/IP ENTRY DATE
  2019-05-23
SOURCE
  Spinal Cord (2019). Date of Publication: 2019
DATE OF PUBLICATION
  2019
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Retrospective study. Objectives: To investigate the risk 
factors associated with tracheostomy after traumatic cervical spinal cord 
injury (CSCI) and to identify factors associated with decannulation in an 
aging population. Setting: Advanced critical care and emergency center in 
Yokohama, Japan. Methods: Sixty-five patients over 60 years with traumatic 
CSCI treated between January 2010 and June 2017 were enrolled. The 
parameters analyzed were age, sex, American Spinal Injury Association 
impairment scale score (AIS) at admission and one year after injury, 
neurological level of injury (NLI), injury mechanism, Charlson’s comorbidity 
index (CCI), smoking history, radiological findings, intubation at arrival, 
treatment choice, length of intensive care unit (ICU) stay, tracheostomy 
rate, improvement of AIS, decannulation rate, and mortality after one year. 
Results: The study included 48 men (74%; mean age 72.8 ± 8.3 years). 
Twenty-two (34%), 10 (15%), 24 (37%), and 9 (14%) patients were classified 
as AIS A, B, C, and D, respectively. The tracheostomy group showed 
significantly more severe degree of paralysis, more patients with major 
fractures or dislocations, more operative treatment, longer ICU stay, poorer 
improvement in AIS score after one year and higher rate of intubation at 
arrival. AIS A at injury was the most significant risk factor for 
tracheostomy. The non-decannulation group had a significantly higher 
mortality. The risk factor for failure of decannulation was CCI. 
Conclusions: Risk factors for tracheostomy after traumatic CSCI were AIS A, 
operative treatment, major fracture/dislocation, and intubation at arrival. 
The only factor for failure of decannulation was CCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aging; cervical spinal cord injury; risk factor; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  aged; American Spinal Injury Association impairment scale; article; comorbidity; controlled study; emergency health service; female; fracture dislocation; human; intensive care unit; intubation; Japan; major clinical study; male; mortality; nervous system; paralysis; retrospective study; risk assessment; smoking; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  31076645 (http://www.ncbi.nlm.nih.gov/pubmed/31076645)
PUI
  L627750033
DOI
  10.1038/s41393-019-0289-x
FULL TEXT LINK
  http://dx.doi.org/10.1038/s41393-019-0289-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fs41393-019-0289-x&atitle=Analysis+of+the+risk+factors+for+tracheostomy+and+decannulation+after+traumatic+cervical+spinal+cord+injury+in+an+aging+population&stitle=Spinal+Cord&title=Spinal+Cord&volume=&issue=&spage=&epage=&aulast=Higashi&aufirst=Takayuki&auinit=T.&aufull=Higashi+T.&coden=SPCOF&isbn=&pages=-&date=2019&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 31
TITLE
  Combined tracheostomy and thyroidectomy in a patient with cervical spine 
fracture
AUTHOR NAMES
  Bonatti H.; Elsouri K.; Elsouri N.
AUTHOR ADDRESSES
  (Bonatti H., hugo.bonatti@dr.com) Meritus Surgical Specialists, Hagerstown, 
United States.
(Elsouri K.; Elsouri N.) Critical Care, Meritus Health, Hagerstown, United 
States.
CORRESPONDENCE ADDRESS
  H. Bonatti, Meritus Surgical Specialists, 11110 Medical Campus Road, Suite 
147, Hagerstown, United States. Email: hugo.bonatti@dr.com
AiP/IP ENTRY DATE
  2019-06-04
FULL RECORD ENTRY DATE
  2019-06-07
SOURCE
  Respiratory Medicine Case Reports (2019) 27 Article Number: 100860. Date of 
Publication: 1 Jan 2019
VOLUME
  27
DATE OF PUBLICATION
  1 Jan 2019
ISSN
  2213-0071 (electronic)
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Background: Combined tracheostomy and thyroidectomy is usually done in case 
of removal of a large goiter causing damage to the tracheal wall. 
Thyroidectomy to get access to the trachea for surgical airway is a rare 
procedure. Tracheostomy following cervical spinal fracture is challenging as 
no hyperextension can be provided limiting exposure. Case report: A 
45-year-old intoxicated male with a head on bicycle accident suffered a C1 
fracture and cervical spinal shock requiring emergent intubation. The C1 
fracture was managed with a cervical collar. The patient improved 
neurologically on the ICU; however, he could not be weaned from mechanical 
ventilation thus requiring tracheostomy. On initial trauma CT-scan, a large 
goiter displacing the trachea to the left side was seen. He was kept in line 
stabilized using towels in the OR. A 5 cm transverse neck incision was made. 
The large partially retrosternal goiter reaching the aortic arch was 
stepwise mobilized out of the neck. The isthmus was divided; the enlarged 
right lobe was brought out of the neck and resected. The trachea was pulled 
to the midline, crosswise incised, the skin flaps were sutured down and a 7 
Shiley cannula was inserted. A PEG tube was placed. The patient had a 
protracted course but ultimately was transferred alert and oriented to a 
long-term rehabilitation facility moving all extremities. Conclusion: 
Combined thyroidectomy with tracheostomy in the setting of cervical fracture 
is technically challenging but was an essential step in the recovery of this 
patient.
EMTREE DRUG INDEX TERMS
  gentamicin (adverse drug reaction, drug therapy); heparin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture (diagnosis, therapy); thyroidectomy; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; African American; article; artificial ventilation; balance disorder; bicycle; case report; cervical collar; clinical article; computer assisted tomography; drug withdrawal; emergency ward; first cervical vertebra; follow up; goiter (diagnosis, surgery); hematoma; hemodialysis; hospital admission; human; hypotension; incision; intensive care unit; intoxication; intubation; kidney failure (side effect, therapy); long term care; low drug dose; lung infection (complication, drug therapy); male; middle aged; operating room; palliative therapy; patient transport; percutaneous endoscopic gastrostomy tube; priority journal; prognosis; Pseudomonas infection (complication, drug therapy); quality of life; rehabilitation care; respiratory distress (surgery); skin flap; surgical approach; surgical drainage; surgical technique; thorax radiography; traffic accident; 
CAS REGISTRY NUMBERS
  gentamicin (1392-48-9, 1403-66-3, 1405-41-0)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L2002034715
DOI
  10.1016/j.rmcr.2019.100860
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rmcr.2019.100860
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22130071&id=doi:10.1016%2Fj.rmcr.2019.100860&atitle=Combined+tracheostomy+and+thyroidectomy+in+a+patient+with+cervical+spine+fracture&stitle=Respir.+Med.+Case+Rep.&title=Respiratory+Medicine+Case+Reports&volume=27&issue=&spage=&epage=&aulast=Bonatti&aufirst=Hugo&auinit=H.&aufull=Bonatti+H.&coden=&isbn=&pages=-&date=2019&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 32
TITLE
  FIREFISH Part 1: Early clinical results following an increase of survival of 
motor neuron protein (SMN) in babies with Type 1 spinal muscular atrophy 
(SMA) treated with risdiplam (RG7916)
AUTHOR NAMES
  Baranello G.; Servais L.; Day J.W.; Deconinck N.; Mercuri E.; Klein A.; Darras B.; Masson R.; Kletzl H.; Cleary Y.; El-Khairi M.; Seabrook T.; Czech C.; Gerber M.; Somugompely P.; Gelblin K.; Gorni K.; Khwaja O.
AUTHOR ADDRESSES
  (Baranello G.; Masson R.) Carlo Besta Neurological Research Institute 
Foundation, Developmental Neurology Unit, Milan, Italy.
(Servais L.) Institute of Myology, Paris, France.
(Servais L.) Reference Center for Neuromuscular Disease, Centre Hospitalier 
Regional de la Citadelle, Liege, Belgium.
(Day J.W.) Department of Neurology, Stanford University, Palo Alto, United 
States.
(Deconinck N.) Queen Fabiola Children's University Hospital and Universite 
Libre de Bruxelles, Brussels, Belgium.
(Deconinck N.) Neuromuscular Reference Center UZ Ghent, Ghent, Belgium.
(Mercuri E.) Paediatric Neurology and Nemo Center, Catholic University and 
Policlinico Gemelli, Rome, Italy.
(Klein A.) University Children's Hospital Basel, Basel, Switzerland.
(Klein A.) Inselspital, Bern, Switzerland.
(Darras B.) Boston Children's Hospital, Harvard Medical School, Boston, 
United States.
(Kletzl H.; Cleary Y.; Seabrook T.; Czech C.; Gerber M.; Somugompely P.; 
Gelblin K.; Gorni K.; Khwaja O.) Roche Pharmaceutical Research and Early 
Development, Roche Innovation Center, Basel, Switzerland.
(El-Khairi M.) Roche Products Limited, Welwyn Garden City, United Kingdom.
CORRESPONDENCE ADDRESS
  G. Baranello, Carlo Besta Neurological Research Institute Foundation, 
Developmental Neurology Unit, Milan, Italy.
FULL RECORD ENTRY DATE
  2019-01-30
SOURCE
  Developmental Medicine and Child Neurology (2019) 61 Supplement 1 (7-8). 
Date of Publication: 1 Jan 2019
VOLUME
  61
FIRST PAGE
  7
LAST PAGE
  8
DATE OF PUBLICATION
  1 Jan 2019
CONFERENCE NAME
  2019 British Paediatric Neurology Association Annual Conference, BPNA 2019
CONFERENCE LOCATION
  Liverpool, United Kingdom
CONFERENCE DATE
  2019-01-23 to 2019-01-25
ISSN
  1469-8749
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Objective: Spinal muscular atrophy (SMA) is characterised by motor neuron 
loss and muscle atrophy, due to reduced levels of survival of motor neuron 
(SMN) protein from loss of function of the SMN1 gene. While SMN1 produces 
full-length SMN protein, a second gene, SMN2, produces low levels of 
functional SMN protein. Risdiplam (RG7916; RO7034067) is an investigational, 
orally administered, centrally and peripherally distributed small molecule 
that modulates SMN2 premRNA splicing to increase SMN protein levels. We 
report on FIREFISH Part 1 (NCT02913482), an ongoing, multicentre, 
open-label, two-part, seamless study of risdiplam in babies aged 1-7 months 
with Type 1 SMA and two SMN2 gene copies. Methods: Part 1 is exploratory and 
principally assesses the safety, tolerability, pharmacokinetics and 
pharmacodynamics of different risdiplam dose levels (enrolment complete). 
Confirmatory Part 2 (n=40) assesses safety and efficacy of risidiplam, with 
a primary endpoint of the proportion of babies sitting without support for 5 
seconds after 12 months. Results: Part 1 interim analysis showed a 
dose-dependent increase in SMN protein levels in whole blood, with an up to 
6.5-fold increase vs. baseline after 4-weeks of treatment at the highest 
dose of risdiplam (2.0-6.5-fold). To date, no safetyrelated stopping rules 
have been met, and none of the following events have been reported: loss of 
ability to swallow, tracheostomy, or permanent ventilation. Part 1 motor 
milestone, safety, and survival data for babies that have been treated for a 
minimum of 6-months will be presented. Conclusions: The up to 6.5-fold 
increase in SMN protein observed in Part 1 is expected to lead to clinical 
efficacy based on the differences in SMN protein levels between SMA severity 
types (eg, Type 2 vs. Type 1 with differences of ~2-fold). All doses 
explored so far have been well tolerated. Part 2 of the FIREFISH study is 
ongoing.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  risdiplam; survival motor neuron protein; survival motor neuron protein 1; 
EMTREE DRUG INDEX TERMS
  endogenous compound; survival motor neuron protein 2; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  clinical article; conference abstract; controlled study; drug megadose; drug safety; drug therapy; female; gene expression; human; human cell; infant; male; multicenter study; pharmacokinetics; protein blood level; tracheostomy; 
CAS REGISTRY NUMBERS
  risdiplam (1825352-65-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L626089076
DOI
  10.1111/dmcn.14119
FULL TEXT LINK
  http://dx.doi.org/10.1111/dmcn.14119
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14698749&id=doi:10.1111%2Fdmcn.14119&atitle=FIREFISH+Part+1%3A+Early+clinical+results+following+an+increase+of+survival+of+motor+neuron+protein+%28SMN%29+in+babies+with+Type+1+spinal+muscular+atrophy+%28SMA%29+treated+with+risdiplam+%28RG7916%29&stitle=Dev.+Med.+Child+Neurol.&title=Developmental+Medicine+and+Child+Neurology&volume=61&issue=&spage=7&epage=8&aulast=Baranello&aufirst=G.&auinit=G.&aufull=Baranello+G.&coden=&isbn=&pages=7-8&date=2019&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 33
TITLE
  FIREFISH Part 1: Early clinical results following an increase of survival of 
motor neuron protein (SMN) in infants with Type 1 spinal muscular atrophy 
(SMA) treated with risdiplam (RG7916)
AUTHOR NAMES
  Baranello G.; Servais L.; Day J.W.; Deconinck N.; Mercuri E.; Klein A.; Darras B.; Masson R.; Kletzl H.; Cleary Y.; El-Khairi M.; Seabrook T.; Czech C.; Gerber M.; Somugompely P.; Gelblin K.; Gorni K.; Khwaja O.
AUTHOR ADDRESSES
  (Baranello G., Giovanni.Baranello@istituto-besta.it; Masson R.) Dubowitz 
Neuromuscular Centre, Developmental Neurology Unit, Fondazione IRCCS 
Istituto Neurologico Carlo Besta, Milan, Italy.
(Servais L.) Institute of Myology, Paris, France, Reference Center for 
Neuromuscular Disease, Centre Hospitalier Régional de la Citadelle, Liège, 
Belgium.
(Day J.W.) Department of Neurology, Stanford University, Palo Alto, United 
States.
(Deconinck N.) Queen Fabiola Children's University Hospital, Université 
Libre de Bruxelles, Brussels, Belgium, Neuromuscular Reference Center UZ 
Ghent, Ghent, Belgium.
(Mercuri E.) Paediatric Neurology and Nemo Center, Catholic University and 
Policlinico Gemelli, Rome, Italy.
(Klein A.) University Children's Hospital Basel, Basel, Switzerland, 
Inselspital, Bern, Switzerland.
(Darras B.) Boston Children's Hospital, Harvard Medical School, Boston, 
United States.
(Kletzl H.; Cleary Y.; Seabrook T.; Czech C.; Gerber M.; Somugompely P.; 
Gelblin K.; Gorni K.; Khwaja O.) Roche Pharmaceutical Research and Early 
Development, Roche Innovation Center Basel, Basel, Switzerland.
(El-Khairi M.) Roche Products Ltd, Welwyn Garden City, United Kingdom.
CORRESPONDENCE ADDRESS
  G. Baranello, Dubowitz Neuromuscular Centre, Developmental Neurology Unit, 
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. Email: 
Giovanni.Baranello@istituto-besta.it
FULL RECORD ENTRY DATE
  2019-05-15
SOURCE
  Journal of Neuromuscular Diseases (2019) 6 Supplement 1 (S60-S61). Date of 
Publication: 2019
VOLUME
  6
FIRST PAGE
  S60
LAST PAGE
  S61
DATE OF PUBLICATION
  2019
CONFERENCE NAME
  12th UK Neuromuscular Translational Research Conference
CONFERENCE LOCATION
  Newcastle upon Tyne, United Kingdom
CONFERENCE DATE
  2019-04-04 to 2019-04-05
ISSN
  2214-3602
BOOK PUBLISHER
  IOS Press
ABSTRACT
  Background: Spinal muscular atrophy (SMA) is characterised by motor neuron 
loss and muscle atro-phy, due to reduced levels of survival of motor neuron 
(SMN) protein from loss of function of the SMN1 gene. While SMN1 produces 
full-length SMN protein, a second gene, SMN2, produces low levels of 
functional SMN protein. Risdiplam (RG7916; RO7034067) is an investigational, 
orally administered, centrally and peripherally distributed small molecule 
that modulates SMN2 pre-mRNA splicing to increase SMN protein levels. Aim: 
To report on the FIREFISH Part 1 dose-find-ing study (NCT02913482), an 
ongoing, multicentre, open-label, two-part, seamless study of risdiplam in 
infants aged 1-7 months with Type 1 SMA and two SMN2 gene copies. Methods: 
Part 1 is exploratory and principally assesses the safety, tolerability, 
pharmacokinetics and pharmacodynamics of different risdiplam dose levels 
(enrolment complete). Confirmatory Part 2 (n=40) assesses safety and 
efficacy of risdiplam, with a primary endpoint of the proportion of infants 
sitting without support for 5 seconds after 12 months. Results: Part 1 
interim analysis presents a dose-dependent increase in SMN protein levels in 
whole blood, with an up to 6.5-fold increase vs. baseline after 4 weeks of 
treatment at the highest dose of ris-diplam (2.0-6.5-fold). To date 
(data-cut 07/09/18), no safety-related stopping rules have been met, and 
none of the following events have been reported: loss of ability to swallow, 
tracheostomy, or permanent ventilation. Part 1 motor milestone, safety, and 
survival data for infants that have been treated for a minimum of 6 months 
will be presented. Conclusion: The up to 6.5-fold increase in SMN protein 
observed in Part 1 is expected to lead to clinical efficacy based on the 
differences in SMN protein levels between SMA severity types (e.g., Type 2 
vs. Type 1 with differences of ~2-fold). Part 2 of the FIREFISH study is 
ongoing.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  risdiplam; survival motor neuron protein; survival motor neuron protein 1; 
EMTREE DRUG INDEX TERMS
  endogenous compound; survival motor neuron protein 2; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  clinical article; conference abstract; controlled study; drug megadose; drug safety; drug therapy; female; gene expression; human; human cell; infant; male; multicenter study; pharmacokinetics; protein blood level; tracheostomy; 
CAS REGISTRY NUMBERS
  risdiplam (1825352-65-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L627605715
DOI
  10.3233/JND-190000
FULL TEXT LINK
  http://dx.doi.org/10.3233/JND-190000
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22143602&id=doi:10.3233%2FJND-190000&atitle=FIREFISH+Part+1%3A+Early+clinical+results+following+an+increase+of+survival+of+motor+neuron+protein+%28SMN%29+in+infants+with+Type+1+spinal+muscular+atrophy+%28SMA%29+treated+with+risdiplam+%28RG7916%29&stitle=J.+Neuromusc.+Dis.&title=Journal+of+Neuromuscular+Diseases&volume=6&issue=&spage=S60&epage=S61&aulast=Baranello&aufirst=Giovanni&auinit=G.&aufull=Baranello+G.&coden=&isbn=&pages=S60-S61&date=2019&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 34
TITLE
  Preoperative Variables Associated With Respiratory Complications After 
Pediatric Neuromuscular Spine Deformity Surgery
AUTHOR NAMES
  Luhmann S.J.; Furdock R.
AUTHOR ADDRESSES
  (Luhmann S.J., luhmanns@wustl.edu; Furdock R.) Pediatric Orthopaedic 
Surgery, Washington University School of Medicine, St. Louis, United States.
CORRESPONDENCE ADDRESS
  S.J. Luhmann, St Louis Children's Hospital, 1 Children's Place, Suite 4S60, 
St Louis, United States. Email: luhmanns@wustl.edu
AiP/IP ENTRY DATE
  2018-07-09
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Spine Deformity (2019) 7:1 (107-111). Date of Publication: 1 Jan 2019
VOLUME
  7
ISSUE
  1
FIRST PAGE
  107
LAST PAGE
  111
DATE OF PUBLICATION
  1 Jan 2019
ISSN
  2212-1358 (electronic)
  2212-134X
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Objective: The objective of this study is to identify preoperative 
laboratory values and patient factors that are associated with postoperative 
respiratory complications in pediatric neuromuscular scoliosis (NMS) 
populations undergoing posterior spinal fusion (PSF) with instrumentation. 
Summary of Background Data: PSF in NMS patients are high-risk surgeries. 
Respiratory complications are the most common postoperative event, with 
rates up to 28.2% following surgery. Methods: A single-surgeon, two-hospital 
pediatric spine surgery database was reviewed to identify all patients who 
underwent PSF for NMS. Diagnoses included cerebral palsy (n=83), 
myelomeningocele (n=13), spinal muscular atrophy (n=4), and other (n=11). 
This study defined respiratory complications as postoperative pneumonia, 
pleural effusion, pneumothorax, need for reintubation, respiratory status 
requiring a return to the pediatric intensive care unit (PICU), or prolonged 
(>4-day) need for mechanical ventilation. Preoperative laboratory values for 
transferrin, prealbumin, hemoglobin/hematocrit, total protein, albumin, and 
total lymphocyte count were collected. Results: There were 50 males and 61 
females with a mean age of 14 years 2.5 months (8–20 years). Seventeen 
patients (15.3%) experienced postoperative respiratory complications. On 
univariate analysis, any history of pneumonia, the presence of gastrostomy 
tube, and low transferrin levels were associated with postoperative 
respiratory complications, and a strong trend (p=.06) was observed for 
tracheostomy. On multivariate analysis, the presence of gastrostomy tube and 
history of pneumonia remained as clinically significant predictors of 
postoperative respiratory complications. Conclusion: Pediatric NMS patients 
undergoing PSF that have history of pneumonia or gastrostomy tube present at 
time of surgery are at increased risk for postoperative respiratory 
complications. The univariate associations of tracheostomy presence and low 
transferrin levels with postoperative respiratory complications deserve 
further examination. Level of Evidence: Level II.
EMTREE DRUG INDEX TERMS
  albumin (endogenous compound); hemoglobin (endogenous compound); protein (endogenous compound); transferrin (endogenous compound); transthyretin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  postoperative complication (complication); respiratory tract disease (complication); spine malformation (surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; artificial ventilation; centronuclear myopathy (surgery); cerebral palsy (surgery); child; Dandy Walker syndrome (surgery); Duchenne muscular dystrophy (surgery); Dwayne syndrome (surgery); female; globoid cell leukodystrophy (surgery); hematocrit; human; hydromyelia (surgery); Leigh disease (surgery); leukocyte; lymphocyte count; major clinical study; male; meningomyelocele (surgery); pediatric intensive care unit; pleura effusion; pneumonia; pneumothorax; preoperative evaluation; priority journal; school child; scoliosis (surgery); spinal muscular atrophy (surgery); stomach tube; tracheostomy; young adult; 
CAS REGISTRY NUMBERS
  hemoglobin (9008-02-0)
  protein (67254-75-5)
  transferrin (82030-93-1)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30587301 (http://www.ncbi.nlm.nih.gov/pubmed/30587301)
PUI
  L2000917284
DOI
  10.1016/j.jspd.2018.05.005
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jspd.2018.05.005
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22121358&id=doi:10.1016%2Fj.jspd.2018.05.005&atitle=Preoperative+Variables+Associated+With+Respiratory+Complications+After+Pediatric+Neuromuscular+Spine+Deformity+Surgery&stitle=Spine+Deform.&title=Spine+Deformity&volume=7&issue=1&spage=107&epage=111&aulast=Luhmann&aufirst=Scott+J.&auinit=S.J.&aufull=Luhmann+S.J.&coden=&isbn=&pages=107-111&date=2019&auinit1=S&auinitm=J
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 35
TITLE
  Car seats: Facing backward is the way forward
AUTHOR NAMES
  Gan J.H.; Davison C.; Prince N.; Gour A.
AUTHOR ADDRESSES
  (Gan J.H.; Davison C.; Prince N.; Gour A., anamigour@gmail.com) Paediatric 
Intensive Care, St George’s Hospital, London, United Kingdom.
CORRESPONDENCE ADDRESS
  A. Gour, Paediatric Intensive Care Unit, St George’s Hospital, First Floor, 
Lanesborough Wing, St., London, United Kingdom. Email: anamigour@gmail.com
AiP/IP ENTRY DATE
  2018-03-14
FULL RECORD ENTRY DATE
  2018-12-13
SOURCE
  Trauma (United Kingdom) (2019) 21:1 (68-72). Date of Publication: 1 Jan 2019
VOLUME
  21
ISSUE
  1
FIRST PAGE
  68
LAST PAGE
  72
DATE OF PUBLICATION
  1 Jan 2019
ISSN
  1460-4086
BOOK PUBLISHER
  SAGE Publications Ltd, info@sagepub.co.uk
ABSTRACT
  Road traffic accidents are one of the commonest causes of death in children. 
Child safety car seats have played a pivotal role in reducing the mortality 
and morbidity associated with road traffic accidents. However, there have 
been some concerns about the about the design of front facing car seats 
versus their rear facing counterparts. Legislation governing the use of rear 
facing car seats is variable, with some Scandinavian countries recommending 
their use up to the age of four, while others mandate their use only until 
one year of age. We present three case narratives of patients aged under 3 
years who sustained catastrophic injuries after being involved in a road 
traffic accident despite being placed in an appropriately sized forward 
facing car seat. We reviewed the literature for evidence comparing the 
safety and efficacy of front versus rear facing car seats. Accident registry 
and crash test results support the increased safety of rear facing child 
seats. Frontal sled test have demonstrated that forward facing car seats 
expose children to much higher neck loads and chest displacement resulting 
in higher injury scores. Epidemiological data from registries and 
observational studies support the experimental data and demonstrate a clear 
injury-reducing effect of rear facing child seats compared to their forward 
facing counterpart. We recommend keeping children in rear facing car seats 
until the age of four, which is common practice in Sweden.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child restraint system; child safety; traffic accident; 
EMTREE MEDICAL INDEX TERMS
  article; aspiration pneumonia (complication); autonomic dysfunction (complication); brain fourth ventricle; brain hematoma; brain hemorrhage (diagnosis); brain hypoxia (diagnosis); brain stem; case report; cervical spinal cord injury (diagnosis); chest tube; child; clinical article; computer assisted tomography; consciousness; death; diabetes insipidus (complication); emergency ward; female; heart arrest (therapy); human; hydrocephalus (diagnosis); infant; intracranial pressure monitoring device; intractable epilepsy (complication); intubation; male; neurorehabilitation; nuclear magnetic resonance imaging; pediatric intensive care unit; pneumothorax (diagnosis); preschool child; quadriplegia (complication); return of spontaneous circulation; spinal cord injury; spinal cord lesion (complication); spinal hematoma (complication); subarachnoid hemorrhage (complication); subluxation; thoracostomy; tracheostomy; traction therapy; treatment withdrawal; ventricular drain; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L621158864
DOI
  10.1177/1460408618755811
FULL TEXT LINK
  http://dx.doi.org/10.1177/1460408618755811
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14604086&id=doi:10.1177%2F1460408618755811&atitle=Car+seats%3A+Facing+backward+is+the+way+forward&stitle=Trauma&title=Trauma+%28United+Kingdom%29&volume=21&issue=1&spage=68&epage=72&aulast=Gan&aufirst=Jo+Han&auinit=J.H.&aufull=Gan+J.H.&coden=TLUKA&isbn=&pages=68-72&date=2019&auinit1=J&auinitm=H
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 36
TITLE
  Spinal muscular atrophy with respiratory distress type 1 associated with 
novel compound heterozygous mutations in IGHMBP2: Differential diagnosis in 
a case with congenital diaphragm eventration
AUTHOR NAMES
  Yasui Y.; Sato H.; Niida Y.; Kohno M.
AUTHOR ADDRESSES
  (Yasui Y., yoshitom@kanazawa-med.ac.jp; Kohno M.) Department of Pediatric 
Surgery, Kanazawa Medical University, Ishikawa, Japan.
(Sato H.) Department of Pediatrics, Kanazawa Medical University, Ishikawa, 
Japan.
(Niida Y.) Division of Clinical Genetics, Kanazawa Medical University, 
Ishikawa, Japan.
CORRESPONDENCE ADDRESS
  Y. Yasui, Department of Pediatric Surgery, Kanazawa Medical University, 
Ishikawa, Japan. Email: yoshitom@kanazawa-med.ac.jp
AiP/IP ENTRY DATE
  2018-04-10
FULL RECORD ENTRY DATE
  2019-01-11
SOURCE
  Congenital Anomalies (2019) 59:1 (22-23). Date of Publication: 1 Jan 2019
VOLUME
  59
ISSUE
  1
FIRST PAGE
  22
LAST PAGE
  23
DATE OF PUBLICATION
  1 Jan 2019
ISSN
  1741-4520 (electronic)
  0914-3505
BOOK PUBLISHER
  Blackwell Publishing
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gene mutation; IGHMBP2 gene; respiratory distress (complication, diagnosis); spinal muscular atrophy (congenital disorder, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; case report; clinical article; congenital diaphragm eventration (congenital disorder, diagnosis); diaphragm eventration (congenital disorder, diagnosis); differential diagnosis; disease association; electromyography; fluoroscopy; gene; heterozygote; human; infant; Japanese (people); male; note; priority journal; thorax radiography; tracheostomy; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Developmental Biology and Teratology (21)
  Human Genetics (22)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  29575095 (http://www.ncbi.nlm.nih.gov/pubmed/29575095)
PUI
  L621550515
DOI
  10.1111/cga.12280
FULL TEXT LINK
  http://dx.doi.org/10.1111/cga.12280
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17414520&id=doi:10.1111%2Fcga.12280&atitle=Spinal+muscular+atrophy+with+respiratory+distress+type+1+associated+with+novel+compound+heterozygous+mutations+in+IGHMBP2%3A+Differential+diagnosis+in+a+case+with+congenital+diaphragm+eventration&stitle=Congenit.+Anomal.&title=Congenital+Anomalies&volume=59&issue=1&spage=22&epage=23&aulast=Yasui&aufirst=Yoshitomo&auinit=Y.&aufull=Yasui+Y.&coden=SEIJA&isbn=&pages=22-23&date=2019&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 37
TITLE
  Airway management for general anesthesia in patients with rheumatic diseases 
- New possibilities
AUTHOR NAMES
  Gaszyński T.
AUTHOR ADDRESSES
  (Gaszyński T., tomasz.gaszynski@umed.lodz.pl) Department of Anaesthesiology 
and Intensive Therapy, Medical University of Łódź, 22 Kopcińskiego St., 
Łódź, Poland.
CORRESPONDENCE ADDRESS
  T. Gaszyński, Department of Anaesthesiology and Intensive Therapy, Medical 
University of Łódź, 22 Kopcińskiego St., Łódź, Poland. Email: 
tomasz.gaszynski@umed.lodz.pl
AiP/IP ENTRY DATE
  2019-06-11
FULL RECORD ENTRY DATE
  2019-06-17
SOURCE
  Reumatologia (2019) 57:2 (69-71). Date of Publication: 2019
VOLUME
  57
ISSUE
  2
FIRST PAGE
  69
LAST PAGE
  71
DATE OF PUBLICATION
  2019
ISSN
  0034-6233
BOOK PUBLISHER
  Termedia Publishing House Ltd., Kleeberqa St.2, Poznan, Poland.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  general anesthesia; respiration control; rheumatic disease; 
EMTREE MEDICAL INDEX TERMS
  ankylosing spondylitis; bronchoscopy; cervical spine; endotracheal intubation; human; laryngeal mask; laryngoscopy; local anesthesia; prognathia; review; risk factor; spinal cord compression; spinal cord lesion; subluxation; temporomandibular joint; temporomandibular joint disorder; tracheostomy; videolaryngoscope; 
DEVICE TRADE NAMES
  Glidescope  , CanadaSaturn Biomedical Systems

  McGrath  , United StatesMedtronic

DEVICE MANUFACTURERS
   (Canada)Saturn Biomedical Systems
   (United States)Medtronic
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Arthritis and Rheumatism (31)
LANGUAGE OF ARTICLE
  English
PUI
  L2002061169
DOI
  10.5114/reum.2019.84810
FULL TEXT LINK
  http://dx.doi.org/10.5114/reum.2019.84810
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00346233&id=doi:10.5114%2Freum.2019.84810&atitle=Airway+management+for+general+anesthesia+in+patients+with+rheumatic+diseases+-+New+possibilities&stitle=Reumatologia&title=Reumatologia&volume=57&issue=2&spage=69&epage=71&aulast=Gaszy%C5%84ski&aufirst=Tomasz&auinit=T.&aufull=Gaszy%C5%84ski+T.&coden=RMTOA&isbn=&pages=69-71&date=2019&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 38
TITLE
  Results from Phase I Clinical Trial with Intraspinal Injection of Neural 
Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome
AUTHOR NAMES
  Mazzini L.; Gelati M.; Profico D.C.; Sorarù G.; Ferrari D.; Copetti M.; Muzi G.; Ricciolini C.; Carletti S.; Giorgi C.; Spera C.; Frondizi D.; Masiero S.; Stecco A.; Cisari C.; Bersano E.; Marchi F.D.; Sarnelli M.F.; Querin G.; Cantello R.; Petruzzelli F.; Maglione A.; Zalfa C.; Binda E.; Visioli A.; Trombetta D.; Torres B.; Bernardini L.; Gaiani A.; Massara M.; Paolucci S.; Boulis N.M.; Vescovi A.L.
AUTHOR ADDRESSES
  (Mazzini L., mazzini.l@libero.it; Bersano E.; Marchi F.D.; Sarnelli M.F.; 
Cantello R.; Massara M.; Paolucci S.) Eastern Piedmont University, “Maggiore 
della Carità” Hospital, Dipartimento di Neurologia, Novara, Italy.
(Gelati M.; Muzi G.; Ricciolini C.; Vescovi A.L., vescovia@gmail.com) 
Laboratorio Cellule Staminali, Cell Factory e Biobanca, Terni Hospital, 
Italy.
(Gelati M.; Profico D.C.; Vescovi A.L., vescovia@gmail.com) Fondazione IRCCS 
Casa Sollievo della Sofferenza, Advanced Therapies Production Unit, San 
Giovanni Rotondo,Foggia, Italy.
(Sorarù G.; Masiero S.; Querin G.; Gaiani A.) Department of Neuroscience, 
University of Padua, Padua, Italy.
(Ferrari D.; Zalfa C.; Vescovi A.L., vescovia@gmail.com) Biotechnology and 
Bioscience Department Bicocca University, Milan, Italy.
(Copetti M.) Fondazione IRCCS Casa Sollievo della Sofferenza, Biostatistic 
Unit, San Giovanni Rotondo, Foggia, Italy.
(Carletti S.; Giorgi C.; Spera C.; Frondizi D.) Department of Neurosurgery 
and Neuroscience, “Santa Maria” Hospital, Terni, Italy.
(Stecco A.) Department of Diagnostic and Interventional Radiology, “Eastern 
Piedmont” University, “Maggiore della Carità” Hospital, Novara, Italy.
(Cisari C.) Department of Physical Therapy, “Eastern Piedmont” University, 
“Maggiore della Carità” Hospital, Novara, Italy.
(Petruzzelli F.; Maglione A.) Fondazione IRCCS Casa Sollievo della 
Sofferenza, Obstetrics and Gynaecology Department, San Giovanni Rotondo, 
Foggia, Italy.
(Binda E.) Fondazione IRCCS Casa Sollievo della Sofferenza, Cancer Stem 
Cells Unit, San Giovanni Rotondo, Foggia, Italy.
(Visioli A.) StemGen SpA, Milan, Italy.
(Trombetta D.) Fondazione IRCCS Casa Sollievo della Sofferenza, Department 
of Oncology, San Giovanni Rotondo, Foggia, Italy.
(Torres B.; Bernardini L.) Fondazione IRCCS Casa Sollievo della Sofferenza, 
Cytogenetics Unit, San Giovanni Rotondo, Foggia, Italy.
(Boulis N.M.) Department of Neurosurgery, Emory University, Atlanta, United 
States.
()
CORRESPONDENCE ADDRESS
  L. Mazzini, Eastern Piedmont University, “Maggiore della Carità” Hospital, 
Dipartimento di Neurologia, Novara, Italy. Email: mazzini.l@libero.it
AiP/IP ENTRY DATE
  2019-05-30
SOURCE
  Stem Cells Translational Medicine (2019). Date of Publication: 2019
DATE OF PUBLICATION
  2019
ISSN
  2157-6580 (electronic)
  2157-6564
BOOK PUBLISHER
  John Wiley and Sons Ltd., contentdelivery@wiley.com
ABSTRACT
  The main objective of this phase I trial was to assess the feasibility and 
safety of microtransplanting human neural stem cell (hNSC) lines into the 
spinal cord of patients with amyotrophic lateral sclerosis (ALS). Eighteen 
patients with a definite diagnosis of ALS received microinjections of hNSCs 
into the gray matter tracts of the lumbar or cervical spinal cord. Patients 
were monitored before and after transplantation by clinical, psychological, 
neuroradiological, and neurophysiological assessment. For up to 60 months 
after surgery, none of the patients manifested severe adverse effects or 
increased disease progression because of the treatment. Eleven patients 
died, and two underwent tracheotomy as a result of the natural history of 
the disease. We detected a transitory decrease in progression of ALS 
Functional Rating Scale Revised, starting within the first month after 
surgery and up to 4 months after transplantation. Our results show that 
transplantation of hNSC is a safe procedure that causes no major deleterious 
effects over the short or long term. This study is the first example of 
medical transplantation of a highly standardized cell drug product, which 
can be reproducibly and stably expanded ex vivo, comprising hNSC that are 
not immortalized, and are derived from the forebrain of the same two donors 
throughout this entire study as well as across future trials. Our 
experimental design provides benefits in terms of enhancing both intra- and 
interstudy reproducibility and homogeneity. Given the potential therapeutic 
effects of the hNSCs, our observations support undertaking future phase II 
clinical studies in which increased cell dosages are studied in larger 
cohorts of patients. Stem Cells Translational Medicine 2019.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult stem cell; amyotrophic lateral sclerosis; cell therapy; fetal stem cell; microinjection; neural stem cell; 
EMTREE MEDICAL INDEX TERMS
  adult; adverse event; article; cervical spinal cord; cohort analysis; controlled study; diagnosis; disease exacerbation; drug safety; ex vivo study; experimental design; feasibility study; female; forebrain; gray matter; history; human; human cell; human tissue; male; phase 1 clinical trial; rating scale; reproducibility; stem cell line; surgery; therapy effect; tracheostomy; transplantation; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  31104357 (http://www.ncbi.nlm.nih.gov/pubmed/31104357)
PUI
  L627827405
DOI
  10.1002/sctm.18-0154
FULL TEXT LINK
  http://dx.doi.org/10.1002/sctm.18-0154
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21576580&id=doi:10.1002%2Fsctm.18-0154&atitle=Results+from+Phase+I+Clinical+Trial+with+Intraspinal+Injection+of+Neural+Stem+Cells+in+Amyotrophic+Lateral+Sclerosis%3A+A+Long-Term+Outcome&stitle=Stem+Cells+Transl.+Med.&title=Stem+Cells+Translational+Medicine&volume=&issue=&spage=&epage=&aulast=Mazzini&aufirst=Letizia&auinit=L.&aufull=Mazzini+L.&coden=&isbn=&pages=-&date=2019&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 39
TITLE
  Transoral approach to the craniovertebral junction: A neuronavigated cadaver 
study
AUTHOR NAMES
  Signorelli F.; Costantini A.; Stumpo V.; Conforti G.; Olivi A.; Visocchi M.
AUTHOR ADDRESSES
  (Signorelli F., francesco.signorelli1984@gmail.com; Stumpo V.; Conforti G.; 
Olivi A.; Visocchi M.) Institute of Neurosurgery, Catholic University School 
of Medicine, Rome, Italy.
(Costantini A.) Institute of Radiology, Catholic University School of 
Medicine, Rome, Italy.
CORRESPONDENCE ADDRESS
  F. Signorelli, Institute of Neurosurgery, Catholic University School of 
Medicine, Rome, Italy. Email: francesco.signorelli1984@gmail.com
AiP/IP ENTRY DATE
  2019-01-31
FULL RECORD ENTRY DATE
  2019-02-05
SOURCE
  Acta Neurochirurgica, Supplementum (2019) 125 (51-55). Date of Publication: 
2019
VOLUME
  125
FIRST PAGE
  51
LAST PAGE
  55
DATE OF PUBLICATION
  2019
ISSN
  2197-8395 (electronic)
  0065-1419
BOOK PUBLISHER
  Springer-Verlag Wien, michaela.bolli@springer.at
ABSTRACT
  More than 100 years after the first description by Kanavel of a 
transoral–transpharyngeal approach to remove a bullet impacted between the 
atlas and the clivus [1], the transoral approach (TOA) still represents the 
‘gold standard’ for surgical treatment of a variety of conditions resulting 
in anterior craniocervical compression and myelopathy [2, 3]. Nevertheless, 
some concerns—such as the need for a temporary tracheostomy and a 
postoperative nasogastric tube, and the increased risk of infection 
resulting from possible bacterial contamination and nasopharyngeal 
incompetence [4–6]—led to the introduction of the endoscopic endonasal 
approach (EEA) by Kassam et al. [7] in 2005. Although this approach, which 
was conceived to overcome those surgical complications, soon gained wide 
attention, its clear predominance over the TOA in the treatment of 
craniovertebral junction (CVJ) pathologies is still a matter of debate [3]. 
In recent years, several papers have reported anatomical studies and 
surgical experience with the EEA, targeting different areas of the midline 
skull base, from the olfactory groove to the CVJ [8–19]. Starting from these 
preliminary experiences, further anatomical studies have defined the 
theoretical (radiological) and practical (surgical) craniocaudal limits of 
the endonasal route [20–25]. Our group has done the same for the TOA [26, 
27] and compared the reliability of the radiological and surgical lines of 
the two different approaches. Very recently, a cadaver study, with the aid 
of neuronavigation, tried to define the upper and lower limits of the 
endoscopic TOA [28].
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  craniovertebral junction (surgery); neuromuscular disease (surgery); neuronavigation; surgical approach; transoral approach; 
EMTREE MEDICAL INDEX TERMS
  cadaver; clinical article; digital imaging and communications in medicine; human; three dimensional imaging; x-ray computed tomography; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30610302 (http://www.ncbi.nlm.nih.gov/pubmed/30610302)
PUI
  L626115933
DOI
  10.1007/978-3-319-62515-7_8
FULL TEXT LINK
  http://dx.doi.org/10.1007/978-3-319-62515-7_8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21978395&id=doi:10.1007%2F978-3-319-62515-7_8&atitle=Transoral+approach+to+the+craniovertebral+junction%3A+A+neuronavigated+cadaver+study&stitle=Acta+Neurochir.+Suppl.&title=Acta+Neurochirurgica%2C+Supplementum&volume=125&issue=&spage=51&epage=55&aulast=Signorelli&aufirst=Francesco&auinit=F.&aufull=Signorelli+F.&coden=ANCSB&isbn=&pages=51-55&date=2019&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 40
TITLE
  Radiological and clinical outcome after multilevel anterior cervical 
discectomy and/or corpectomy and fixation
AUTHOR NAMES
  Oni P.; Schultheiß R.; Scheufler K.-M.; Roberg J.; Harati A.
AUTHOR ADDRESSES
  (Oni P., paul.oni@klinikumdo.de; Schultheiß R., 
rolf.schultheiss@klinikumdo.de; Scheufler K.-M., 
kai-michael.scheufler@klinikumdo.de; Roberg J., jakob.roberg@klinikumdo.de; 
Harati A., a.harati@gmx.de) Department of Neurosurgery, Klinikum Dortmund, 
Dortmund, Germany.
CORRESPONDENCE ADDRESS
  A. Harati, Department of Neurosurgery, Klinikum Dortmund, Dortmund, Germany. 
Email: a.harati@gmx.de
AiP/IP ENTRY DATE
  2018-12-03
FULL RECORD ENTRY DATE
  2018-12-04
SOURCE
  Journal of Clinical Medicine (2018) 7:12 Article Number: 469. Date of 
Publication: 1 Dec 2018
VOLUME
  7
ISSUE
  12
DATE OF PUBLICATION
  1 Dec 2018
ISSN
  2077-0383 (electronic)
BOOK PUBLISHER
  MDPI AG, Postfach, Basel, Switzerland. indexing@mdpi.com
ABSTRACT
  Background: Multilevel anterior cervical decompression and fixation of four 
and more levels is a common surgical procedure used for several diseases. 
Methods: We reviewed the radiological and clinical outcomes after anterior 
cervical discectomy or corpectomy and fixation of four and more levels in 85 
patients (55 men and 30 women) with an average age of 59.6 years. Surgical 
indication was multilevel cervical degenerative myelopathy and radiculopathy 
in 72 (85%) patients, multilevel cervical spondylodiscitis in four (5%), 
complex traumatic cervical fractures in four (5%), metastatic cervical spine 
tumor in two (2%), and ossification of the posterior longitudinal ligament 
in three (3%) patients. Results: There were no severe intraoperative 
complications such as spinal cord or vertebral artery injury or dissection. 
Seventy-three patients had four, 10 patients had five, and two patients had 
six anterior cervical level fixations. The visual analog scale (VAS) and 
Japanese Orthopedic Association (mJOA) scale scores improved (6.9 to 1.3 (p 
< 0.001) and 13.9 to 16.5 (p < 0.001), respectively). The Cobb angle 
increased from 5.7° to 17.6° postoperatively (p < 0.001). Secondary 
posterior fixation was necessary in three cases due to pseudarthrosis. 
Conclusion: The anterior approach appears to be optimal for ventral 
compressive pathology and lordosis restoration to the cervical spine. 
Limitations of multiple level decompression and fixation included increasing 
pseudoarthrosis rates, especially after corpectomy, and increasing fused 
level numbers.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  corpectomy; discectomy; multilevel analysis; osteosynthesis; radiodiagnosis; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; biomechanics; Boker und Schultheib; cervical myelopathy; cervical spine fracture; Cobb angle; computer assisted tomography; controlled study; degenerative disease; esophagus injury; evaluation and follow up; female; human; hygo c Cage; infection; intervertebral disk degeneration; Japanese Orthopaedic Association score; kyphosis; ligament calcinosis; locking screw; lordosis; lung insufficiency; major clinical study; male; middle aged; motor function test; nuclear magnetic resonance imaging; osteomyelitis; pathology; peroperative care; platysma muscle; pseudarthrosis; quadriplegia; radiculopathy; retrospective study; skin tingling; spinal cord compression; spinal hematoma; spondylosis; sternocleidomastoid muscle; Streptococcus anginosus; titanium mesh; tracheostomy; upper limb; vertebral artery; visual analog scale; 
DEVICE TRADE NAMES
  Boker und Schultheib
  hygo c Cage
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180838750
PUI
  L625114242
DOI
  10.3390/jcm7120469
FULL TEXT LINK
  http://dx.doi.org/10.3390/jcm7120469
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20770383&id=doi:10.3390%2Fjcm7120469&atitle=Radiological+and+clinical+outcome+after+multilevel+anterior+cervical+discectomy+and%2For+corpectomy+and+fixation&stitle=J.+Clin.+Med.&title=Journal+of+Clinical+Medicine&volume=7&issue=12&spage=&epage=&aulast=Oni&aufirst=Paul&auinit=P.&aufull=Oni+P.&coden=&isbn=&pages=-&date=2018&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 41
TITLE
  10-year all-cause-mortality of home mechanical ventilation
AUTHOR NAMES
  Schwarz E.I.; Mackie M.; Tincknell L.; Beghal G.; Ramsay M.; Suh E.; Kaltsakas G.; Pattani H.; Marino P.; Murphy P.; Hart N.; Steier J.
AUTHOR ADDRESSES
  (Schwarz E.I.; Mackie M.; Ramsay M.; Suh E.; Kaltsakas G.; Pattani H.; 
Marino P.; Murphy P.; Hart N.; Steier J.) Guy's and St Thomas' NHS 
Foundation Trust, London, United Kingdom.
(Tincknell L.; Beghal G.) King's College London, London, United Kingdom.
CORRESPONDENCE ADDRESS
  E.I. Schwarz,
FULL RECORD ENTRY DATE
  2019-05-21
SOURCE
  Thorax (2018) 73 Supplement 4 (A77). Date of Publication: 1 Dec 2018
VOLUME
  73
FIRST PAGE
  A77
DATE OF PUBLICATION
  1 Dec 2018
CONFERENCE NAME
  British Thoracic Society Winter Meeting, BTS 2018
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2018-12-05 to 2018-12-07
ISSN
  1468-3296
BOOK PUBLISHER
  BMJ Publishing Group
ABSTRACT
  Introduction Home mechanical ventilation (HMV) is used to treat chronic 
hypercapnic respiratory failure. There is mounting evidence that HMV impacts 
on long-term outcomes in different disease groups with chronic hypercapnic 
respiratory failure. However, outcomes differ according to the underlying 
condition. Methods All-cause mortality data of patients on HMV between 2008 
and 2018 were collected from patients treated in a large tertiary referral 
centre for non-invasive ventilation and weaning, currently treating around 
2000 patients on HMV. Cumulative mortality on HMV was compared between 
patients with neuromuscular disease/chest wall disease (NMD/CWD), 
obstructive airway disease (OAD), obesity-related respiratory failure 
(ORRF), overlap of OAD and ORRF (Overlap Syndrome) and others (e.g. 
traumatic spinal cord injury). The main outcome was time on HMV until death 
in the key groups. Results are reported as median [interquartile range]. 
Results In total, 1081 deaths of patients on HMV were recorded within a 10 
year period. Time until death on HMV was 19 [6-54] months for the entire 
cohort but differed between the groups (Kruskal Wallis p<0.001). Patients 
with ORRF (n=189, 32 [12-68] months) and Overlap Syndrome (n=39, 28 [13-63] 
months) had a longer median survival than patients with OAD (n=261, 20 
[7-42] months), NMD/CWD (n=469, 16 [5-59] months) or others (n=123, 14 
[3-38] months; figure 1). Within the heterogeneous group of NMD/ CWD, 
patients with CWD (n=51, 97 [19-120] months) and myopathy (n=146, 62 
[28-120] months) had a longer survival than patients with motor neurone 
disease (n=225, 7 [2-14] months). Daily usage of >4 hour on HMV was 
associated with longer survival in those who were not dependent on 24h-HMV. 
There was no relevant difference in outcomes between patients on 
non-invasive ventilation (NIV; n=940) and tracheostomy (n=141), but the 
latter group was relatively small. Over 33% of patients on HMV died outside 
and 45% in the hospital, for 22% the exact location of death was unknown. 
Conclusion Long-term mortality in patients treated with HMV for chronic 
hypercapnic respiratory differs significantly between disease groups. 
Patients with chest wall disease, myopathy or obesity-related respiratory 
failure have a lower mortality than patients with MND, neuropathy, OAD or 
traumatic spinal cord injuries (Figure Presented) .
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  all cause mortality; noninvasive ventilation; 
EMTREE MEDICAL INDEX TERMS
  adult; conference abstract; controlled study; death; female; human; hypercapnia; hypoventilation; major clinical study; male; median survival time; motor neuron disease; neuromuscular disease; neuropathy; obesity; obstructive airway disease; respiratory failure; spinal cord injury; tertiary care center; thorax wall; tracheostomy; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L627697715
DOI
  10.1136/thorax-2018-212555.129
FULL TEXT LINK
  http://dx.doi.org/10.1136/thorax-2018-212555.129
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14683296&id=doi:10.1136%2Fthorax-2018-212555.129&atitle=10-year+all-cause-mortality+of+home+mechanical+ventilation&stitle=Thorax&title=Thorax&volume=73&issue=&spage=A77&epage=&aulast=Schwarz&aufirst=E.I.&auinit=E.I.&aufull=Schwarz+E.I.&coden=&isbn=&pages=A77-&date=2018&auinit1=E&auinitm=I
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 42
TITLE
  The Burden of Pediatric Neurocritical Care in the United States
AUTHOR NAMES
  Williams C.N.; Piantino J.; McEvoy C.; Fino N.; Eriksson C.O.
AUTHOR ADDRESSES
  (Williams C.N., willicyd@ohsu.edu; Eriksson C.O.) Oregon Health and Science 
University, Department of Pediatrics, Division of Pediatric Critical Care, 
Portland, United States.
(Piantino J.) Division of Pediatric Neurology, Portland, United States.
(McEvoy C.) Division of Neonatology, Portland, United States.
(Fino N.) Oregon Health and Science University, Biostatistics and Design 
Program, Portland, United States.
CORRESPONDENCE ADDRESS
  C.N. Williams, Oregon Health and Science University, Department of 
Pediatrics, 707 SW Gaines St, CDRC-P, Portland, United States. Email: 
willicyd@ohsu.edu
AiP/IP ENTRY DATE
  2018-10-18
FULL RECORD ENTRY DATE
  2018-12-18
SOURCE
  Pediatric Neurology (2018) 89 (31-38). Date of Publication: 1 Dec 2018
VOLUME
  89
FIRST PAGE
  31
LAST PAGE
  38
DATE OF PUBLICATION
  1 Dec 2018
ISSN
  1873-5150 (electronic)
  0887-8994
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background: Disorders requiring pediatric neurocritical care (PNCC) affect 
thousands of children annually. We aimed to quantify the burden of PNCC 
through generation of national estimates of disease incidence, utilization 
of critical care interventions (CCI), and hospital outcomes. Methods: We 
performed a retrospective cohort analysis of the Kids Inpatient Database 
over three years to evaluate pediatric traumatic brain injury, 
neuro-infection or inflammatory diseases, status epilepticus, stroke, 
hypoxic ischemic injury after cardiac arrest, and spinal cord injury. We 
evaluated use of CCI, death, length of stay, hospital charges, and poor 
functional outcome defined as receipt of tracheostomy or gastrostomy or 
discharge to a medical care facility. Results: At least one CCI was recorded 
in 67,058 (23%) children with a primary neurological diagnosis, and 
considered a PNCC admission. Over half of PNCC admissions had at least one 
chronic condition, and 23% were treated in children's hospitals. Mechanical 
ventilation was the most common CCI, but utilization of CCIs varied 
significantly by diagnosis. Among PNCC admissions, 8110 (12%) children died 
during hospitalization and 14,067 (21%) children had poor functional 
outcomes. PNCC admissions cumulatively accounted for over 1.5 million 
hospital days and over $4 billion in hospital costs in the study years. Most 
PNCC admissions, across all diagnoses, had prolonged hospitalizations (more 
than one week) with an average cost of $39.9 thousand per admission. 
Conclusions: This large, nationally representative study shows PNCC diseases 
are a significant public health burden with substantial risk to children's 
health. More research is needed to improve outcomes in these vulnerable 
children.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain abscess; brain hemorrhage; brain infection; brain ischemia; encephalitis; epileptic state; heart arrest; meningitis; neurological intensive care unit; spinal cord injury; traumatic brain injury; 
EMTREE MEDICAL INDEX TERMS
  article; child; cohort analysis; controlled study; female; gastrostomy; health care facility; health care utilization; hospital admission; hospital discharge; hospitalization; human; male; population research; priority journal; public health; retrospective study; tracheostomy; United States; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Hematology (25)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30327237 (http://www.ncbi.nlm.nih.gov/pubmed/30327237)
PUI
  L2001179553
DOI
  10.1016/j.pediatrneurol.2018.07.013
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pediatrneurol.2018.07.013
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18735150&id=doi:10.1016%2Fj.pediatrneurol.2018.07.013&atitle=The+Burden+of+Pediatric+Neurocritical+Care+in+the+United+States&stitle=Pediatr.+Neurol.&title=Pediatric+Neurology&volume=89&issue=&spage=31&epage=38&aulast=Williams&aufirst=Cydni+N.&auinit=C.N.&aufull=Williams+C.N.&coden=PNEUE&isbn=&pages=31-38&date=2018&auinit1=C&auinitm=N
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 43
TITLE
  Risk factors for dysphagia after a spinal cord injury: a systematic review 
and meta-analysis
AUTHOR NAMES
  Iruthayarajah J.; McIntyre A.; Mirkowski M.; Welch-West P.; Loh E.; Teasell R.
AUTHOR ADDRESSES
  (Iruthayarajah J., Jerome.Iruthayarajah@sjhc.london.on.ca; McIntyre A.; 
Mirkowski M.; Loh E.; Teasell R.) Lawson Health Research Institute, Parkwood 
Institute, London, Canada.
(Welch-West P.; Loh E.; Teasell R.) Parkwood Institute, St. Joseph’s Health 
Care London, London, Canada.
(Loh E.; Teasell R.) Schulich School of Medicine & Dentistry, University of 
Western Ontario, London, Canada.
CORRESPONDENCE ADDRESS
  J. Iruthayarajah, Lawson Health Research Institute, Parkwood Institute, 
London, Canada. Email: Jerome.Iruthayarajah@sjhc.london.on.ca
AiP/IP ENTRY DATE
  2018-07-04
FULL RECORD ENTRY DATE
  2018-12-17
SOURCE
  Spinal Cord (2018) 56:12 (1116-1123). Date of Publication: 1 Dec 2018
VOLUME
  56
ISSUE
  12
FIRST PAGE
  1116
LAST PAGE
  1123
DATE OF PUBLICATION
  1 Dec 2018
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Systematic review and meta-analysis. Objective: To determine 
the risk factors predictive of dysphagia after a spinal cord injury (SCI). 
Setting: None. Methods: A comprehensive literature search was performed in 
five scientific databases for English articles that identified risk factors 
for dysphagia after a SCI in adult (≥19 years) individuals. Data extracted 
included: author name, year and country of publication, participant 
demographics, sample size, study design, method of dysphagia diagnosis, and 
risk factor percentages. Methodological quality of studies was assessed 
using the Newcastle–Ottawa Scale. For identified risk factors, risk 
percentages were transformed into risk ratios (RR) with 95% confidence 
intervals. Quantitative synthesis was performed for risk factors reported in 
two or more studies using restricted maximum-likelihood estimator random 
effects models. Results: Eleven studies met inclusion criteria of which ten 
studies were of moderate quality (n = 10). Significant risk factors 
included: age, injury severity, level of injury, presence of tracheostomy, 
coughing, voice quality, bronchoscopy need, pneumonia, mechanical 
ventilation, nasogastric tubes, comorbid injury, and a cervical surgery. 
Results of the quantitative synthesis indicated that the presence of a 
tracheostomy posed a threefold greater risk of the development of dysphagia 
(RR: 3.67); while, cervical surgery posed a 1.3 times greater risk of the 
development of dysphagia (RR: 1.30). Conclusions: Knowledge of these risk 
factors can be a resource for clinicians in the early diagnosis and 
appropriate medical management of dysphagia post SCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (complication); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; bronchoscopy; comorbidity; coughing; human; injury severity; nasogastric tube; nutritional status; pneumonia; priority journal; review; risk factor; spine surgery; systematic review; tracheostomy; voice; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29955090 (http://www.ncbi.nlm.nih.gov/pubmed/29955090)
PUI
  L622800571
DOI
  10.1038/s41393-018-0170-3
FULL TEXT LINK
  http://dx.doi.org/10.1038/s41393-018-0170-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fs41393-018-0170-3&atitle=Risk+factors+for+dysphagia+after+a+spinal+cord+injury%3A+a+systematic+review+and+meta-analysis&stitle=Spinal+Cord&title=Spinal+Cord&volume=56&issue=12&spage=1116&epage=1123&aulast=Iruthayarajah&aufirst=J.&auinit=J.&aufull=Iruthayarajah+J.&coden=SPCOF&isbn=&pages=1116-1123&date=2018&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 44
TITLE
  Axial chordoma of the cervical spine managed by a trans-mandibular 
trans-oral approach
AUTHOR NAMES
  Younus A.; Kelly A.; Lekgwara P.
AUTHOR ADDRESSES
  (Younus A.) Department of Orthopedics, Helen Joseph Hospital, University of 
the Witwatersrand, Johannesburg, South Africa.
(Kelly A., adriankelly1000@yahoo.co.uk; Lekgwara P.) Department of 
Neurosurgery, Dr George Mukhari Academic Hospital, Sefako Makgatho Health 
Sciences University, Pretoria, South Africa.
(Kelly A., adriankelly1000@yahoo.co.uk) Department of Neurosurgery, Sefako 
Makgatho Health Sciences University, 3rd floor Sciences Building, Garankuwa, 
South Africa.
CORRESPONDENCE ADDRESS
  A. Kelly, Department of Neurosurgery, Dr George Mukhari Academic Hospital, 
Sefako Makgatho Health Sciences University, Pretoria, South Africa. Email: 
adriankelly1000@yahoo.co.uk
AiP/IP ENTRY DATE
  2018-09-12
FULL RECORD ENTRY DATE
  2018-09-14
SOURCE
  Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 
(2018) 14 (173-177). Date of Publication: 1 Dec 2018
VOLUME
  14
FIRST PAGE
  173
LAST PAGE
  177
DATE OF PUBLICATION
  1 Dec 2018
ISSN
  2214-7519 (electronic)
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  Chordomas are low-grade but locally aggressive malignant neoplasms derived 
from notochordal remnants. These lesions are best treated by en bloc however 
this is especially challenging in the upper cervical spine due to the 
proximity of vital structures. We present a 46 year old male whom presented 
to our unit complaining of progressive upper cervical axial neck pain 
aggravated by neck rotation, of 4 months duration. He had no symptoms of 
myelopathy. Examination revealed high posterior spinal tenderness and 
resistance to neck rotation however the patient's motor and sensory 
examinations were normal and he had normal gait. An inter-disciplinary team 
comprising Orthopedics, Neurosurgery, Maxillofacial surgery and 
Otorhinolaryngology took the patient for surgery. The first stage of the 
procedure comprised Otorhinolaryngology performing a tracheostomy and 
thereafter a combined Orthopedic Neurosurgical procedure involving a 
posterior instrumented C1–C3/C4 fusion and biopsy of the lesion. The second 
stage involved the maxillofacial surgeons dividing the patient's mandible to 
increase operative exposure. Thereafter the Orthopedic and Neurosurgical 
surgeons proceeded to perform a transmandibular transoral en bloc resection 
of the body and odontoid process of C2 which was replaced by a cage 
construct. The vertebral arteries were preserved and no dural breech 
occurred. Post operatively the patient showed no new neurology and was 
ambulant. He was maintained in a Philadelphia collar for 6 weeks until his 
fusion was complete. In conclusion this difficult case was managed 
successfully by thorough pre-operative planning and inter-departmental 
co-operation. Fortunately the lesion was isolated to the body and odontoid 
process of C2 which was in the patients favor lending the case towards a 
favorable outcome.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  axial chordoma (surgery); cancer surgery; chordoma (surgery); mandible resection; spine tumor (surgery); surgical approach; trans mandibular trans oral approach; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cancer patient; case report; clinical article; dental surgeon; disease duration; human; laminectomy; male; medical history; middle aged; neck pain; nuclear magnetic resonance imaging; odontoid process; physical examination; priority journal; surgical patient; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180618681
PUI
  L2001076803
DOI
  10.1016/j.inat.2018.08.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.inat.2018.08.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22147519&id=doi:10.1016%2Fj.inat.2018.08.004&atitle=Axial+chordoma+of+the+cervical+spine+managed+by+a+trans-mandibular+trans-oral+approach&stitle=Interdiscip.+Neurosurg.+Adv.+Tech.+Case+Manage.&title=Interdisciplinary+Neurosurgery%3A+Advanced+Techniques+and+Case+Management&volume=14&issue=&spage=173&epage=177&aulast=Younus&aufirst=Aftab&auinit=A.&aufull=Younus+A.&coden=&isbn=&pages=173-177&date=2018&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 45
TITLE
  Fibrocartilaginous embolization - A rare cause of spinal cord infarction: 
Case report
AUTHOR NAMES
  Lišková Z.; Lehotská V.; Liška M.; Mikula P.
AUTHOR ADDRESSES
  (Lišková Z.) 1st Radiology Department, Faculty of Medicine, Comenius 
University in Bratislava, Slovak Medical University and University Hospital 
Bratislava, Bratislava, Slovakia.
(Lišková Z.; Mikula P.) CT and MR department, Radiologia s.r.o., University 
Hospital Bratislava, Bratislava, Slovakia.
(Lehotská V., viera.lehotska@ousa.sk) 2nd Radiology Department, Faculty of 
Medicine, Comenius University in Bratislava and St, Elizabeth’s Cancer 
Institute Bratislava, Bratislava, Slovakia.
(Liška M.) Clinic of Anaesthesiology and Intensive Medicine, Faculty of 
Medicine of Slovak Medical University in Bratislava, University Hospital 
Bratislava, Bratislava, Slovakia.
(Lišková Z.; Mikula P.) nd Radiology Department, Faculty of Medicine of 
Comenius University in Bratislava and St. Elizabeth´s Cancer Institute 
Bratislava, Heydukova 10, Bratislava, Slovakia.
CORRESPONDENCE ADDRESS
  V. Lehotská, nd Radiology Department, Faculty of Medicine of Comenius 
University in Bratislava and St. Elizabeth´s Cancer Institute Bratislava, 
Heydukova 10, Bratislava, Slovakia. Email: viera.lehotska@ousa.sk
AiP/IP ENTRY DATE
  2019-02-28
FULL RECORD ENTRY DATE
  2019-03-01
SOURCE
  Journal of Radiology Case Reports (2018) 12:12 (1-9). Date of Publication: 1 
Dec 2018
VOLUME
  12
ISSUE
  12
FIRST PAGE
  1
LAST PAGE
  9
DATE OF PUBLICATION
  1 Dec 2018
ISSN
  1943-0922 (electronic)
BOOK PUBLISHER
  EduRad, P.O. Box 1570 Lincoln,, California, United States.
ABSTRACT
  A case of fibrocartilaginous embolization in 24-year-old female as a rare 
cause of spinal cord infarction is presented. It manifests as infarction 
syndrome with rapid progression of clinical signs-acute onset of 
quadriparesis and respiratory insufficiency. Among imaging studies MRI is 
the most accurate as it readily capable of detection of myelopathy and acute 
intervertebral disc lesion. Other laboratory tests and imaging modalities 
are usually normal. The final diagnosis is made by exclusion.
EMTREE DRUG INDEX TERMS
  antibiotic agent; anticoagulant agent; corticosteroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  embolism; fibrocartilaginous embolization; spinal cord infarction; 
EMTREE MEDICAL INDEX TERMS
  adult; antibody screening; article; artificial ventilation; case report; cervical spine; clinical article; female; follow up; human; intervertebral disk disease; nuclear magnetic resonance imaging; quadriplegia; respiratory failure; spinal cord disease; tracheostomy; young adult; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L2001547228
DOI
  10.3941/jrcr.v12i12.3411
FULL TEXT LINK
  http://dx.doi.org/10.3941/jrcr.v12i12.3411
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19430922&id=doi:10.3941%2Fjrcr.v12i12.3411&atitle=Fibrocartilaginous+embolization+-+A+rare+cause+of+spinal+cord+infarction%3A+Case+report&stitle=J.+Radiol.+Case+Rep.&title=Journal+of+Radiology+Case+Reports&volume=12&issue=12&spage=1&epage=9&aulast=Li%C5%A1kov%C3%A1&aufirst=Zuzana&auinit=Z.&aufull=Li%C5%A1kov%C3%A1+Z.&coden=&isbn=&pages=1-9&date=2018&auinit1=Z&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 46
TITLE
  Mechanical insufflation-exsufflation to improve secretion clearance during 
invasive ventilation
AUTHOR NAMES
  Terzi N.; Prigent H.; Lofaso F.
AUTHOR ADDRESSES
  (Terzi N.) Service de Réanimation Médicale et INSERM Centre Hospitalier 
Universitaire Grenoble Alpes Grenoble, France.
(Prigent H.; Lofaso F., f.lofaso@rpc.aphp.fr) Service d’Explorations 
Fonctionnelles, Hôpital Raymond Poincaré, Garches, France.
(Prigent H.; Lofaso F., f.lofaso@rpc.aphp.fr) INSERM, Université de 
Versailles, Saint Quentin en Yvelines, France.
CORRESPONDENCE ADDRESS
  F. Lofaso, Services de Physiologie et Explorations Fonctionnelles, Hôpital 
Raymond Poincaré, AP-HP, Garches, France. Email: f.lofaso@rpc.aphp.fr
AiP/IP ENTRY DATE
  2018-11-30
FULL RECORD ENTRY DATE
  2018-12-03
SOURCE
  Respiratory Care (2018) 63:12 (1577-1578). Date of Publication: 1 Dec 2018
VOLUME
  63
ISSUE
  12
FIRST PAGE
  1577
LAST PAGE
  1578
DATE OF PUBLICATION
  1 Dec 2018
ISSN
  1943-3654 (electronic)
  0020-1324
BOOK PUBLISHER
  American Association for Respiratory Care
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aeration; artificial ventilation; lung clearance; 
EMTREE MEDICAL INDEX TERMS
  airway resistance; amyotrophic lateral sclerosis; aspiration; atelectasis; breathing exercise; bronchitis; coughing; editorial; endotracheal tube; human; hyperinflation; infection; intensive care unit; length of stay; mucus; noninvasive ventilation; pneumonia; respiratory care; spinal cord injury; total lung capacity; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180835606
MEDLINE PMID
  30467229 (http://www.ncbi.nlm.nih.gov/pubmed/30467229)
PUI
  L625167293
DOI
  10.4187/respcare.06700
FULL TEXT LINK
  http://dx.doi.org/10.4187/respcare.06700
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19433654&id=doi:10.4187%2Frespcare.06700&atitle=Mechanical+insufflation-exsufflation+to+improve+secretion+clearance+during+invasive+ventilation&stitle=Respir.+Care&title=Respiratory+Care&volume=63&issue=12&spage=1577&epage=1578&aulast=Terzi&aufirst=Nicolas&auinit=N.&aufull=Terzi+N.&coden=RECAC&isbn=&pages=1577-1578&date=2018&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 47
TITLE
  Fatal innominate artery hemorrhage in a patient with tetraplegia: Case 
report and literature review
AUTHOR NAMES
  Qureshi A.Z.
AUTHOR ADDRESSES
  (Qureshi A.Z., qureshipmr@gmail.com) Department of Physical Medicine and 
Rehabilitation, King Fahad Medical City, Riyadh, Saudi Arabia.
CORRESPONDENCE ADDRESS
  A.Z. Qureshi, Department of Physical Medicine and Rehabilitation, King Fahad 
Medical City, PO Box 59046, Riyadh, Saudi Arabia. Email: 
qureshipmr@gmail.com
AiP/IP ENTRY DATE
  2018-11-06
FULL RECORD ENTRY DATE
  2018-11-08
SOURCE
  Journal of Spinal Cord Medicine (2018) 41:6 (731-734). Date of Publication: 
2 Nov 2018
VOLUME
  41
ISSUE
  6
FIRST PAGE
  731
LAST PAGE
  734
DATE OF PUBLICATION
  2 Nov 2018
ISSN
  2045-7723 (electronic)
  1079-0268
BOOK PUBLISHER
  Taylor and Francis Ltd., michael.wagreich@univie.ac.at
ABSTRACT
  Context: Hemorrhage is one of the potentially fatal complications of 
tracheostomy. A rare but lethal cause of tracheostomy related bleeding is 
hemorrhage from the innominate artery. This occurs following 
tracheo-innominate artery fistula (TIF) formation, which is associated with 
a mortality rate of more than 85%. Here, we report the case of an individual 
with tetraplegia and a tracheostomy who died as a result of innominate 
artery hemorrhage. This case highlights the possible causes and 
interventions associated with this complication, and provides insight into 
tracheostomy related bleeding in patients with spinal cord injury (SCI). 
Findings: A 15-year-old boy with a diagnosis of incomplete SCI at the C5 
level was admitted for rehabilitation 4 months after injury. He required a 
tracheostomy for ventilation, and underwent subglottic stenosis dilatation 
thrice. Multiple decannulation attempts were performed without success. He 
received intensive care on several occasions for respiratory failure. During 
the course of his rehabilitation, a minimal tracheostomy bleed was observed, 
which became profuse within a few hours and led to hypoxia with loss of 
consciousness. An urgent sternotomy identified bleeding from a TIF. He 
suffered severe brain damage following massive tracheal hemorrhage and died. 
Conclusion/clinical relevance: Given the morbidity of TIF-related 
hemorrhage, it is important to increase awareness of this rare condition 
among health-care providers, especially those in non-acute settings. 
Patients with SCI and a tracheostomy pose unique challenges related to 
respiratory compromise, which may accentuate TIF formation.
EMTREE DRUG INDEX TERMS
  fluticasone propionate plus salmeterol (special situation for 
pharmacovigilance); salbutamol (special situation for pharmacovigilance); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bleeding (complication); blood vessel fistula (complication); brachiocephalic trunk; quadriplegia (rehabilitation); spinal cord injury (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  abrasion; adolescent; article; artificial ventilation; brain damage; breathing exercise; case report; chest infection; clinical article; decubitus (surgery); do not resuscitate order; fatality; heart arrest; home care; human; hypotension; hypoxia; intensive care; male; neurorehabilitation; oxygen saturation; plastic surgery; respiratory care; respiratory failure; sternotomy; subglottic stenosis (surgery); thorax surgery; tracheal hemorrhage; tracheostomy; tracheostomy tube; unconsciousness; 
CAS REGISTRY NUMBERS
  salbutamol (18559-94-9, 35763-26-9)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180767134
MEDLINE PMID
  29323630 (http://www.ncbi.nlm.nih.gov/pubmed/29323630)
PUI
  L624705490
DOI
  10.1080/10790268.2017.1417802
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2017.1417802
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2017.1417802&atitle=Fatal+innominate+artery+hemorrhage+in+a+patient+with+tetraplegia%3A+Case+report+and+literature+review&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=41&issue=6&spage=731&epage=734&aulast=Qureshi&aufirst=Ahmad+Zaheer&auinit=A.Z.&aufull=Qureshi+A.Z.&coden=JSCMC&isbn=&pages=731-734&date=2018&auinit1=A&auinitm=Z
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 48
TITLE
  Ertapenem-associated neurotoxicity in the spinal cord injury (SCI) 
population: A case series
AUTHOR NAMES
  Patel U.C.; Fowler M.A.
AUTHOR ADDRESSES
  (Patel U.C., ursula.patel@va.gov; Fowler M.A.) Department of Pharmacy, 
Edward Hines, Jr. VA Medical Center, Hines, United States.
CORRESPONDENCE ADDRESS
  U.C. Patel, Department of Pharmacy, Edward Hines, Jr. VA Medical Center, 
Hines, United States. Email: ursula.patel@va.gov
AiP/IP ENTRY DATE
  2017-09-21
FULL RECORD ENTRY DATE
  2018-11-08
SOURCE
  Journal of Spinal Cord Medicine (2018) 41:6 (735-740). Date of Publication: 
2 Nov 2018
VOLUME
  41
ISSUE
  6
FIRST PAGE
  735
LAST PAGE
  740
DATE OF PUBLICATION
  2 Nov 2018
ISSN
  2045-7723 (electronic)
  1079-0268
BOOK PUBLISHER
  Taylor and Francis Ltd., michael.wagreich@univie.ac.at
ABSTRACT
  Context: Ertapenem, a broad spectrum carbapenem antibiotic, is used often in 
Spinal Cord Injury (SCI) patients due to increased risk factors for 
multi-drug resistant (MDR) infections in this population. Neurotoxicity, 
specifically seizures, due to ertapenem is a known adverse effect and has 
been described previously. Other manifestations such as delirium and visual 
hallucinations have rarely been reported, and no literature, to the best of 
our knowledge, specifically describes these effects solely in the SCI 
population. Findings: Four cases of mental status changes and hallucinations 
in SCI patients attributed to ertapenem therapy are described. Onset of 
symptoms began between one and six days following initiation of ertapenem 
and resolved between two to 42 days following discontinuation. Based on the 
Naranjo probability scale, a probable relationship exists between the 
adverse events and ertapenem for three out of the four cases. Possible 
overestimation of renal function and hypoalbuminemia may be contributing 
factors to the noted adverse reactions. Conclusion/Clinical Relevance: The 
cases described highlight the importance of recognizing ertapenem-associated 
hallucinations in SCI patients. The population is particularly vulnerable 
due to risk factors for MDR infections necessitating ertapenem use, possible 
overestimation of renal function, and a high prevalence of hypoalbuminemia.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ertapenem (adverse drug reaction, intravenous drug administration, special 
situation for pharmacovigilance); 
EMTREE DRUG INDEX TERMS
  allopurinol (special situation for pharmacovigilance); amlodipine (special situation for pharmacovigilance); antibiotic agent (oral drug administration); atorvastatin (special situation for pharmacovigilance); baclofen (special situation for pharmacovigilance); ceftazidime; cilastatin plus imipenem; creatinine (endogenous compound); diltiazem (special situation for pharmacovigilance); docusate sodium (drug combination, special situation for pharmacovigilance); furosemide (special situation for pharmacovigilance); hydralazine (special situation for pharmacovigilance); isosorbide mononitrate (special situation for pharmacovigilance); lisinopril (special situation for pharmacovigilance); loperamide (special situation for pharmacovigilance); losartan (special situation for pharmacovigilance); meropenem (special situation for pharmacovigilance); metoprolol (special situation for pharmacovigilance); omeprazole (special situation for pharmacovigilance); oxybutynin (special situation for pharmacovigilance); pregabalin (special situation for pharmacovigilance); risperidone (drug dose, special situation for pharmacovigilance); sennoside (drug combination, special situation for pharmacovigilance); simvastatin (special situation for pharmacovigilance); terazosin (special situation for pharmacovigilance); tizanidine (special situation for pharmacovigilance); tramadol (special situation for pharmacovigilance); unindexed drug; vancomycin (intravenous drug administration, special situation for 
pharmacovigilance); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hallucination; mental health; neurotoxicity (side effect); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; agitation; alcohol abuse; antibiotic therapy; article; bladder stone; body height; body weight; bone biopsy; brain atrophy; case report; cellulitis; chronic disease; chronic obstructive lung disease; chronic osteomyelitis; Citrobacter koseri; clinical article; cocaine dependence; confusion; creatinine blood level; decubitus; depression; diabetes mellitus; drug use; Enterobacter cloacae; essential tremor; fasciocutaneous flap; follow up; glaucoma; graft failure; human; hyperlipidemia; hypertension; hypoalbuminemia; hyponatremia; hypothyroidism; iron deficiency anemia; kidney function; leukocytosis; male; medical history; middle aged; neurofibromatosis; neurogenic bladder; neurogenic bowel; osteomyelitis; paraplegia; peripheral neuropathy; peripheral vascular disease; quadriplegia; recurrent infection; respiratory failure; sleep disordered breathing; Staphylococcus epidermidis; stomach tube; tracheostomy; tremor; urinalysis; urinary tract infection; urine culture; vitamin D deficiency; wound care; x-ray computed tomography; 
CAS REGISTRY NUMBERS
  allopurinol (315-30-0)
  amlodipine (88150-42-9, 103129-82-4, 736178-83-9)
  atorvastatin (134523-00-5, 134523-03-8)
  baclofen (1134-47-0)
  ceftazidime (72558-82-8)
  cilastatin plus imipenem (92309-29-0)
  creatinine (19230-81-0, 60-27-5)
  diltiazem (33286-22-5, 42399-41-7)
  docusate sodium (577-11-7)
  ertapenem (153773-82-1, 153832-38-3, 153832-46-3)
  furosemide (54-31-9)
  hydralazine (304-20-1, 86-54-4)
  isosorbide mononitrate (1320-91-8, 16051-77-7)
  lisinopril (76547-98-3, 83915-83-7)
  loperamide (34552-83-5, 53179-11-6)
  losartan (114798-26-4)
  meropenem (96036-03-2)
  metoprolol (37350-58-6)
  omeprazole (73590-58-6, 95510-70-6)
  oxybutynin (1508-65-2, 5633-20-5, 119618-22-3, 230949-16-3)
  pregabalin (148553-50-8)
  risperidone (106266-06-2)
  sennoside (517-43-1, 62211-03-4)
  simvastatin (79902-63-9)
  terazosin (63074-08-8, 63590-64-7)
  tizanidine (51322-75-9, 64461-82-1)
  tramadol (27203-92-5, 36282-47-0)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Psychiatry (32)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  28874102 (http://www.ncbi.nlm.nih.gov/pubmed/28874102)
PUI
  L618299785
DOI
  10.1080/10790268.2017.1368960
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2017.1368960
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2017.1368960&atitle=Ertapenem-associated+neurotoxicity+in+the+spinal+cord+injury+%28SCI%29+population%3A+A+case+series&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=41&issue=6&spage=735&epage=740&aulast=Patel&aufirst=Ursula+C.&auinit=U.C.&aufull=Patel+U.C.&coden=JSCMC&isbn=&pages=735-740&date=2018&auinit1=U&auinitm=C
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 49
TITLE
  AVXS-101 phase 1 gene replacement therapy clinical trial in spinal muscular 
atrophy type 1: Improvement in respiratory and swallowing function 
stabilizes the need for ventilatory and nutritional support, and reduces 
frequency and duration of hospitalizations compared with natural history
AUTHOR NAMES
  Shell R.; Al-Zaidy S.; Arnold W.D.; Rodino-Klapac L.; Prior T.; Kotha K.; Paul G.; Lowes L.; Alfano L.; Berry K.; Church K.; Kissel J.; Nagendran S.; L'Italien J.; Menier M.; Ogrinc F.; Sproule D.; Wells C.; Burghes A.; Foust K.; Meyer K.; Likhite S.; Kaspar B.; Mendell J.
AUTHOR ADDRESSES
  (Shell R.; Kotha K.; Paul G.) Department of Pediatrics, Section of Pulmonary 
Medicine, Nationwide Children's Hospital, Columbus, United States.
(Shell R.; Kotha K.; Paul G.) Department of Pediatrics, Section of Pulmonary 
Medicine, Ohio State University, Columbus, United States.
(Al-Zaidy S.; Rodino-Klapac L.; Lowes L.; Alfano L.; Berry K.; Church K.; 
Meyer K.; Likhite S.; Kaspar B.; Mendell J.) Center for Gene Therapy, 
Nationwide Children's Hospital, Columbus, United States.
(Al-Zaidy S.; Lowes L.; Kissel J.; Kaspar B.; Mendell J.) Department of 
Pediatrics, Ohio State University, Columbus, United States.
(Arnold W.D.; Rodino-Klapac L.; Burghes A.; Kaspar B.; Mendell J.) 
Department Neurology, Ohio State University, Columbus, United States.
(Prior T.) Department of Pathology, Ohio State University, Columbus, United 
States.
(Nagendran S.; L'Italien J.; Menier M.; Ogrinc F.; Sproule D.; Wells C.; 
Foust K.; Kaspar B.) AveXis,Inc., Bannockburn, United States.
(Burghes A.) Department of Biological Chemistry and Pharmacology, Ohio State 
University, Columbus, United States.
CORRESPONDENCE ADDRESS
  R. Shell, Department of Pediatrics, Section of Pulmonary Medicine, 
Nationwide Children's Hospital, Columbus, United States.
FULL RECORD ENTRY DATE
  2018-12-04
SOURCE
  Journal of Pediatric Gastroenterology and Nutrition (2018) 67 Supplement 1 
(S379). Date of Publication: 1 Nov 2018
VOLUME
  67
FIRST PAGE
  S379
DATE OF PUBLICATION
  1 Nov 2018
CONFERENCE NAME
  North American Society for Pediatric Gastroenterology, Hepatology and 
Nutrition Annual Meeting, NASPGHAN 2018
CONFERENCE LOCATION
  Hollywood, FL, United States
CONFERENCE DATE
  2018-10-24 to 2018-10-27
ISSN
  1536-4801
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: Spinal muscular atrophy (SMA), an autosomal recessive 
neurodegenerative disorder, is caused by bi-allelic loss or dysfunction of 
the survival motor neuron 1 (SMN1) gene. With an incidence of approximately 
1 in 10,000 live births and a carrier frequency of approximately 1 in 54, 
SMA is classified into 4 subtypes (1-4) on the basis of age of onset of 
symptoms and motor milestone achievement. Insufficient levels of the 
survival motor neuron (SMN) protein result in loss of motor neurons of the 
brainstem and spinal cord, progressive muscular atrophy, weakness, and 
severe swallowing and breathing dysfunction that increases the likelihood of 
hospitalizations due to failure to thrive, aspiration pneumonia, and 
acute-on-chronic ventilatory failure. According to the natural history of 
SMA1, the majority of patients with SMA1 are not able to speak or swallow 
effectively. By 12 months of age, the majority of patients will require 
nutritional and ventilatory support, and by 20 months of age, 92% are 
expected to die or require permanent ventilation. We report data on bulbar 
function, requirements for nutritional and ventilatory support, 
hospitalizations, and survival in patients with SMA1 treated with 
onasemnogene abeparvovec (AVXS-101), a gene replacement therapy. METHODS: In 
this 2-year follow-up phase 1 trial (NCT02122952), 15 SMA1 patients received 
a one-time, intravenous dose of AVXS-101 at low dose (cohort 1, n=3) or 
proposed therapeutic dose (cohort 2, n=12). All patients had bi-allelic exon 
7 deletions of SMN1, 2xSMN2 copies, and no SMN2 disease modifying mutation. 
Here, we report survival, hospitalizations, bulbar function, and 
nutritional/ventilatory support outcomes in the proposed therapeutic dose 
cohort (cohort 2). Survival was defined as avoidance of death/permanent 
ventilation; swallow integrity was determined using a video swallow test, 
and ventilatory support was parent-reported. RESULTS: At 24 months 
follow-up, 12/12 (100%) patients with SMA1 were alive and without need for 
permanent ventilation. AVXS-101 had a favorable safety profile and was 
generally well tolerated in patients with SMA1. Ten of 12 patients were able 
to safely swallow thin liquids compared with 4 at baseline, and 11/12 were 
able to safely swallow to allow oral feeding compared with 8 at baseline. No 
patient lost the ability to feed orally following AVXS-101. Six patients who 
were feeding orally were not using nutritional support. At baseline, 7/12 
patients did not require nutritional support, and 10/12 did not require 
ventilatory support. At 24 months follow-up, 6/7 patients who did not 
require nutritional support pre-dosing continued to eat exclusively by 
mouth, and 7/10 who did not require ventilatory support pre-dosing continued 
without ventilatory support. Ten patients were hospitalized for respiratory 
infections, but all survived without need for tracheostomy or permanent 
ventilation. Patients treated with AVXS-101 spent a median of 2.3% 
(range=0-18.3) of the time hospitalized; 10/12 (83%) patients treated with 
AVXS-101 were hospitalized <10% of the time (0-36 days/year), and none were 
hospitalized ≥20% of the time (≥73 days/year). The ENDEAR study included a 
control group of untreated patients with SMA1, and reported hospitalization 
data for these untreated patients. The ENDEAR study reported that untreated 
patients with SMA1 were hospitalized a median of 13.9% (range=0-75) of the 
time; 11/27 (41%) untreated patients from the ENDEAR study were hospitalized 
<10% of the time (0-36 days/year), and 10/27 (37%) were hospitalized ≥20% of 
the time (≥73 days/year). The mean unadjusted annualized hospitalization 
rate (hospitalizations/number of subject-years followed) for patients 
treated with AVXS-101 was 2.1 (range=0-7.6), which was half that in the 
ENDEAR control group (4.3). The mean hospital stay was 6.7 days 
(range=3-12.1) in patients treated with AVXS-101, compared with 13 days 
reported in untreated patients. CONCLUSION: In contrast to natural history, 
patients with SMA1 treated with AVXS-101 showed improved survival, improved 
bulbar function, reduced need for nutritional and ventilatory support, and 
reduced frequency and duration of hospitalizations, which may result in a 
significant reduction in healthcare utilization and cost burden on 
healthcare systems.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  onasemnogene abeparvovec; 
EMTREE DRUG INDEX TERMS
  endogenous compound; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gene replacement therapy; history; hospitalization; nutritional support; respiratory function; swallowing; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  allele; artificial ventilation; assisted ventilation; avoidance behavior; cohort analysis; conference abstract; controlled study; death; drug safety; drug therapy; feeding; female; follow up; gene deletion; health care system; health care utilization; human; human cell; infant; intravenous drug administration; low drug dose; major clinical study; male; mouth; pharmacokinetics; phase 1 clinical trial; respiratory tract infection; survival; tracheostomy; videorecording; 
CAS REGISTRY NUMBERS
  onasemnogene abeparvovec (1922968-73-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L625227634
DOI
  10.1097/MPG.0000000000002164
FULL TEXT LINK
  http://dx.doi.org/10.1097/MPG.0000000000002164
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15364801&id=doi:10.1097%2FMPG.0000000000002164&atitle=AVXS-101+phase+1+gene+replacement+therapy+clinical+trial+in+spinal+muscular+atrophy+type+1%3A+Improvement+in+respiratory+and+swallowing+function+stabilizes+the+need+for+ventilatory+and+nutritional+support%2C+and+reduces+frequency+and+duration+of+hospitalizations+compared+with+natural+history&stitle=J.+Pediatr.+Gastroenterol.+Nutr.&title=Journal+of+Pediatric+Gastroenterology+and+Nutrition&volume=67&issue=&spage=S379&epage=&aulast=Shell&aufirst=Richard&auinit=R.&aufull=Shell+R.&coden=&isbn=&pages=S379-&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 50
TITLE
  Use of diaphragm pacing in the management of acute cervical spinal cord 
injury
AUTHOR NAMES
  Kerwin A.J.; Yorkgitis B.K.; Ebler D.J.; Madbak F.G.; Hsu A.T.; Crandall M.L.
AUTHOR ADDRESSES
  (Kerwin A.J., andy.kerwin@jax.ufl.edu; Yorkgitis B.K.; Ebler D.J.; Madbak 
F.G.; Hsu A.T.; Crandall M.L.) University of Florida College of 
Medicine-Jacksonville, Division of Acute Care Surgery, 655 W 8th St, 
Jacksonville, United States.
CORRESPONDENCE ADDRESS
  A.J. Kerwin, University of Florida College of Medicine-Jacksonville, 
Division of Acute Care Surgery, 655 W 8th St, Jacksonville, United States. 
Email: andy.kerwin@jax.ufl.edu
AiP/IP ENTRY DATE
  2018-11-13
FULL RECORD ENTRY DATE
  2018-11-14
SOURCE
  Journal of Trauma and Acute Care Surgery (2018) 85:5 (928-931). Date of 
Publication: 1 Nov 2018
VOLUME
  85
ISSUE
  5
FIRST PAGE
  928
LAST PAGE
  931
DATE OF PUBLICATION
  1 Nov 2018
ISSN
  2163-0763 (electronic)
  2163-0755
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  BACKGROUND Cervical spinal cord injury (CSCI) is devastating. Respiratory 
failure, ventilator-Associated pneumonia (VAP), sepsis, and death frequently 
occur. Case reports of diaphragm pacing system (DPS) have suggested earlier 
liberation from mechanical ventilation in acute CSCI patients. We 
hypothesized DPS implantation would decrease VAP and facilitate liberation 
from ventilation. METHODS We performed a retrospective review of patients 
with acute CSCI managed at a single Level 1 trauma center between January 
2005 and May 2017. Routine demographics were collected. Patients underwent 
propensity matching based on age, injury severity score, ventilator days, 
hospital length of stay, and need for tracheostomy. Outcome measures 
included hospital length of stay, intensive care unit length of stay, 
ventilator days (vent days), incidence of VAP, and mortality. Bivariate and 
multivariate logistic and linear regression statistics were performed using 
STATA Version 10. RESULTS Between July 2011 and May 2017, all patients with 
acute CSCI were evaluated for DPS implantation. Forty patients who had 
laparoscopic DPS implantation (DPS) were matched to 61 who did not (NO DPS). 
Median time to liberation after DPS implantation was 7 days. Hospital length 
of stay and mortality were significantly lower on bivariate analysis in DPS 
patients. Diaphragm pacing system placement was not found to be associated 
with statistically significant differences in these outcomes on 
risk-Adjusted multivariate models that included admission year. CONCLUSIONS 
Diaphragm pacing system implantation in patients with acute CSCI can be one 
part of a comprehensive critical care program to improve outcomes. However, 
the association of DPS with the marked improved mortality seen on bivariate 
analysis may be due solely to improvements in critical care throughout the 
study period. Further studies to define the benefits of DPS implantation are 
needed. LEVEL OF EVIDENCE Therapeutic, level IV.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; cohort analysis; comparative study; conference paper; controlled study; disease association; emergency health service; female; health program; hospital admission; hospitalization; human; injury scale; intensive care unit; length of stay; major clinical study; male; middle aged; mortality; outcome assessment; priority journal; propensity score; respiratory failure; retrospective study; systolic blood pressure; tracheostomy; ventilator associated pneumonia; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180780469
MEDLINE PMID
  29985232 (http://www.ncbi.nlm.nih.gov/pubmed/29985232)
PUI
  L624777911
DOI
  10.1097/TA.0000000000002023
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0000000000002023
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0000000000002023&atitle=Use+of+diaphragm+pacing+in+the+management+of+acute+cervical+spinal+cord+injury&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=85&issue=5&spage=928&epage=931&aulast=Kerwin&aufirst=Andrew+J.&auinit=A.J.&aufull=Kerwin+A.J.&coden=&isbn=&pages=928-931&date=2018&auinit1=A&auinitm=J
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 51
TITLE
  Reporting the largest long term experience with diaphragm pacing for 
traumatic spinal cord injury: Successfully decreasing mechanical ventilation
AUTHOR NAMES
  Onders R.; Elmo M.; Katirji B.; Schilz R.
AUTHOR ADDRESSES
  (Onders R.) University Hospitals Cleveland Medical Center, Surgery, 
Cleveland, United States.
(Elmo M.; Katirji B.; Schilz R.) University Hospitals Cleveland Medical 
Center, Cleveland, United States.
CORRESPONDENCE ADDRESS
  R. Onders, University Hospitals Cleveland Medical Center, Surgery, 
Cleveland, United States.
FULL RECORD ENTRY DATE
  2018-11-16
SOURCE
  Intensive Care Medicine Experimental (2018) 6 Supplement 2. Date of 
Publication: 1 Oct 2018
VOLUME
  6
DATE OF PUBLICATION
  1 Oct 2018
CONFERENCE NAME
  31st European Society of Intensive Care Medicine Annual Congress, ESICM 2018
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2018-10-20 to 2018-10-24
ISSN
  2197-425X
BOOK PUBLISHER
  SpringerOpen
ABSTRACT
  INTRODUCTION. Cervical spine injury (SCI) can result in catastrophic 
respiratory failure requiring invasive mechanical ventilation (MV) which is 
a leading cause of mortality and cost. Diaphragm Pacing (DP) was developed 
to replace/decrease mechanical ventilation. OBJECTIVE. Report the largest 
long term analysis of DP in a sub-group of traumatic SCI. METHODS. A 
retrospective review of prospective IRB approved pro-tocols. All patients 
underwent laparoscopic diaphragm mapping and implantation of electrodes. DP 
electrodes were characterized and diaphragm strengthening with mechanical 
ventilator weaning was initiated immediately post op. RESULTS. March 2000 
through June 2017 there have been a total of 486 DP implants at this single 
site. Within this group, 155 had spinal cord damage and 92 of those patients 
had SCI secondary to trauma. The manner of injury: MVA 44, Sports 22, Falls 
12, GSW 7, Crush 3, Forceps Delivery 2, Assault 1, and electrocution 1. The 
age at time of injury ranged from birth to 74 years old with the average of 
27.3 years and median age of 23 years. Time on mechanical ventilation prior 
to DP was an average of 47.5 months (6 days to 25 years with median of 1.58 
years). Patients' highest level of injury: 27 C1, 36 C2, 14 C3, 7 C4, 5 C5 
and 3 C6. Twelve patients had internal permanent cardiac pacemakers. There 
was no device to device interactions between DP and cardiac pacemakers. A 
total of 83% of patients achieved 4 consecutive hours of pacing with 
fifty-six patients (60.8%) being full time and an additional 13% using DP 
>12 hours. DP decreased the need and risk of cuffed tracheostomy with 60% of 
patients going to cuffless tracheostomy and 7 decannulations. One patient 
with early DP implant avoided tracheostomy. Five patients were not 
successful in weaning off MV. Five patients had full recovery of automatic 
breathing with subsequent DP removal. Two pediatric patients have had growth 
spurts of 10 inches or greater without need of electrode replacement. There 
have been 23 deaths with no primary respiratory origin. Subgroup analysis 
showed that earlier DP implantation leads to greater 24 hour use of DP and 
no need for any MV. This group also had the greater proportionate re-covery 
of breathing. CONCLUSIONS. DP can successfully decrease need for mechanical 
ventilation for a significant number of SCI patients. There is a correlation 
of early implantation to greater weaning success, recovery of independent 
breathing and has the potential to obviate need for tracheostomy. Liberation 
from MV can substantially improve SCI re-habilitation. To minimize MV days 
and complications, DP should be considered early after injury even in those 
who may re-gain independent breathing.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm; spinal cord injury; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  adult; assault; child; complication; conference abstract; death; electrocution; female; forceps delivery; growth acceleration; human; implant; implanted heart pacemaker; major clinical study; male; mechanical ventilator; pacemaker electrode; pediatric patient; remission; retrospective study; spinal cord lesion; sport; tracheostomy; young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624863692
DOI
  10.1186/s40635-018-0201-6
FULL TEXT LINK
  http://dx.doi.org/10.1186/s40635-018-0201-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2197425X&id=doi:10.1186%2Fs40635-018-0201-6&atitle=Reporting+the+largest+long+term+experience+with+diaphragm+pacing+for+traumatic+spinal+cord+injury%3A+Successfully+decreasing+mechanical+ventilation&stitle=Intensive+Care+Med.+Exp.&title=Intensive+Care+Medicine+Experimental&volume=6&issue=&spage=&epage=&aulast=Onders&aufirst=R.&auinit=R.&aufull=Onders+R.&coden=&isbn=&pages=-&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 52
TITLE
  Pedicle screws versus sublaminar wires in posterior spinal fusion in 
patients with cerebral palsy: A matched cohort analysis
AUTHOR NAMES
  Wade shrader M.; Falk M.; Belthur M.; Wood W.
AUTHOR ADDRESSES
  (Wade shrader M.) Nemours A.I. DuPont Hospital for Children, Wilmington, 
United States.
(Falk M.; Belthur M.; Wood W.) Phoenix Children's Hospital, Phoenix, United 
States.
CORRESPONDENCE ADDRESS
  M. Wade shrader, Nemours A.I. DuPont Hospital for Children, Wilmington, 
United States.
FULL RECORD ENTRY DATE
  2019-03-27
SOURCE
  Developmental Medicine and Child Neurology (2018) 60 Supplement 3 (4-5). 
Date of Publication: 1 Oct 2018
VOLUME
  60
FIRST PAGE
  4
LAST PAGE
  5
DATE OF PUBLICATION
  1 Oct 2018
CONFERENCE NAME
  72nd Annual Meeting of the American Academy for Cerebral Palsy and 
Developmental Medicine, AACPDM 2018
CONFERENCE LOCATION
  Cincinnati, OH, United States
CONFERENCE DATE
  2018-10-09 to 2018-10-13
ISSN
  1469-8749
BOOK PUBLISHER
  Wiley Blackwell
ABSTRACT
  Background and Objective(s): Scoliosis is common in children with cerebral 
palsy (CP). Traditionally, posterior spinal fusion (PSF) was performed with 
sublaminar wires and Galveston pelvic fixation (Unit Rods). In many sites 
today, the use of pedicle screws for these patients has become the standard. 
The purpose of this study was to compare the outcomes of patients with CP 
and scoliosis who underwent PSF using an all-screw construct, compared to a 
sublaminar wire/Unit rod construct. Study Design: Matched cohort 
retrospective series (Level III). Study Participants & Setting: Consecutive 
patients with cerebral palsy undergoing spine fusion for scoliosis at a 
tertiary care pediatric hospital Materials/Methods: Patients with CP, GMFCS 
IV or V, undergoing PSF with sublaminar wires and Unit rods were identified 
and matched to a group of patients who had all screw constructs (including 
S2Al pelvic screws). The patients were matched for GMFCS level, age, weight, 
main curve Cobb angle, and medical comorbidities, including the presence of 
G-tube and tracheostomy tubes. All patients were followed for greater than 2 
years. Data collected included age, surgical details (including estimated 
blood loss and surgical time), length of stay (LOS), complications, and Cobb 
angle correction. Comparisons were made with t-tests and Chi-squared 
analyses, or non-parametric equivalents, with significance set at p<0.05. 
Results: 27 patients (mean age 14.1) with a mean preoperative Cobb angle of 
90o in the Unit rod group were matched to an all-Screw cohort (mean age 
15.5) with a mean preoperative Cobb angle of 78o(p=0.28). The Unit rod group 
was followed for a mean 3.5 years, compared to 2.5 in the Screw group. The 
surgical time and EBL were statistically higher in the Unit rod group 
compared to the Screw group (5.5 hr vs 3.33 hr, p<0.00001, and 1070 cc vs 
865 cc, p=0.05). There were more complications in the Unit rod group, 
including 2 pseudarthroses (p=0.03). There were no differences in the % Cobb 
angle correction between the two groups (57 and 58%, p=0.41) 
Conclusions/Significance: In patients with CP, the use of all-Screw 
constructs resulted in less operative time, less blood loss, and less 
complications when compared to the Unit rod group; however, the deformity 
correction was similar. Future studies should investigate the value of using 
screws in this patient population to determine if outcomes are truly 
improved and cost beneficial.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cerebral palsy; cohort analysis; pedicle screw; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  adolescent; bleeding; body weight; clinical article; Cobb angle; comorbidity; complication; conference abstract; controlled study; deformity; feeding tube; female; Gross Motor Function Classification System; human; length of stay; male; operation duration; pediatric hospital; preoperative evaluation; pseudarthrosis; retrospective study; scoliosis; tertiary health care; tracheostomy tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L626873551
DOI
  10.1111/dmcn.03_14017
FULL TEXT LINK
  http://dx.doi.org/10.1111/dmcn.03_14017
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14698749&id=doi:10.1111%2Fdmcn.03_14017&atitle=Pedicle+screws+versus+sublaminar+wires+in+posterior+spinal+fusion+in+patients+with+cerebral+palsy%3A+A+matched+cohort+analysis&stitle=Dev.+Med.+Child+Neurol.&title=Developmental+Medicine+and+Child+Neurology&volume=60&issue=&spage=4&epage=5&aulast=Wade+shrader&aufirst=M.&auinit=M.&aufull=Wade+shrader+M.&coden=&isbn=&pages=4-5&date=2018&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 53
TITLE
  Safety of early tracheostomy in trauma patients after anterior cervical 
fusion
AUTHOR NAMES
  Lozano C.P.; Chen K.A.; Marks J.A.; Jenoff J.S.; Cohen M.J.; Weinstein M.S.
AUTHOR ADDRESSES
  (Lozano C.P., Claudia.Lozano.Bidmc@gmail.com) General Surgery Residency, 
Beth Israel Deaconess Medical Center, Boston, United States.
(Lozano C.P., Claudia.Lozano.Bidmc@gmail.com; Chen K.A.; Marks J.A.; Jenoff 
J.S.; Cohen M.J.; Weinstein M.S.) Sidney Kimmel Medical College, Thomas 
Jefferson University, 1100 Walnut St, Philadelphia, United States.
(Marks J.A.; Jenoff J.S.; Cohen M.J.; Weinstein M.S.) Acute Care Surgery 
Division, Department of Surgery, Thomas Jefferson University Hospital, 
Philadelphia, United States.
CORRESPONDENCE ADDRESS
  C.P. Lozano, Sidney Kimmel Medical College, Thomas Jefferson University, 
1100 Walnut St, Philadelphia, United States. Email: 
Claudia.Lozano.Bidmc@gmail.com
AiP/IP ENTRY DATE
  2018-10-11
FULL RECORD ENTRY DATE
  2018-10-16
SOURCE
  Journal of Trauma and Acute Care Surgery (2018) 85:4 (741-746). Date of 
Publication: 1 Oct 2018
VOLUME
  85
ISSUE
  4
FIRST PAGE
  741
LAST PAGE
  746
DATE OF PUBLICATION
  1 Oct 2018
ISSN
  2163-0763 (electronic)
  2163-0755
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  BACKGROUND Cervical spine injuries (CSIs) can have major effects on the 
respiratory system and carry a high incidence of pulmonary complications. 
Respiratory failure can be due to spinal cord injuries, concomitant facial 
fractures or chest injury, airway obstruction, or cognitive impairments. 
Early tracheostomy (ET) is often indicated in patients with CSI. However, in 
patients with anterior cervical fusion (ACF), concerns about 
cross-contamination often delay tracheostomy placement. This study aimed to 
demonstrate the safety of ET within 4 days of ACF. METHODS Retrospective 
chart review was performed for all trauma patients admitted to our 
institution between 2001 and 2015 with diagnosis of CSI who required both 
ACF and tracheostomy, with or without posterior cervical fusion, during the 
same hospitalization. Thirty-nine study patients with ET (within 4 days of 
ACF) were compared with 59 control patients with late tracheostomy (5-21 
days after ACF). Univariate and logistic regression analyses were performed 
to compare risk of wound infection, length of intensive care unit and 
hospital stay, and mortality between both groups during initial 
hospitalization. RESULTS There was no difference in age, sex, preexisting 
pulmonary or cardiac conditions, Glasgow Coma Scale score, Injury Severity 
Score, Chest Abbreviated Injury Scale score, American Spinal Injury 
Association score, cervical spinal cord injury levels, and tracheostomy 
technique between both groups. There was no statistically significant 
difference in surgical site infection between both groups. There were no 
cases of cervical fusion wound infection in the ET group (0%), but there 
were five cases (8.47%) in the late tracheostomy group (p = 0.15). Four 
involved the posterior cervical fusion wound, and one involved the ACF 
wound. There was no statistically significant difference in intensive care 
unit stay (p = 0.09), hospital stay (p = 0.09), or mortality (p = 0.06) 
between groups. CONCLUSION Early tracheostomy within 4 days of ACF is safe 
without increased risk of infection compared with late tracheostomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical fusion; cervical spine injury (therapy); early tracheostomy; safety procedure; spine surgery; surgical technique; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; adult respiratory distress syndrome; aged; American Spinal Injury Association impairment scale; article; bradycardia; cause of death; comorbidity; electronic medical record; esophagocutaneous fistula; esophagus fistula; esophagus perforation; female; Glasgow coma scale; hospital mortality; hospitalization; human; hypotension; ICD-9-CM; injury scale; intensive care unit; length of stay; lung disease; major clinical study; male; medical record review; priority journal; retrospective study; risk factor; surgical infection; therapy delay; very elderly; wound infection; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180696398
PUI
  L624182222
DOI
  10.1097/TA.0000000000002045
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0000000000002045
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0000000000002045&atitle=Safety+of+early+tracheostomy+in+trauma+patients+after+anterior+cervical+fusion&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=85&issue=4&spage=741&epage=746&aulast=Lozano&aufirst=Claudia+P.&auinit=C.P.&aufull=Lozano+C.P.&coden=&isbn=&pages=741-746&date=2018&auinit1=C&auinitm=P
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 54
TITLE
  Results of Early and Late Surgical Decompression and Stabilization for Acute 
Traumatic Cervical Spinal Cord Injury in Patients with Concomitant Chest 
Injuries
AUTHOR NAMES
  Sewell M.D.; Vachhani K.; Alrawi A.; Williams R.
AUTHOR ADDRESSES
  (Sewell M.D., matbuzz1@hotmail.com; Vachhani K.; Alrawi A.; Williams R.) 
Spinal Unit, James Cook University Hospital, Middlesbrough, United Kingdom.
CORRESPONDENCE ADDRESS
  M.D. Sewell, Spinal Unit, James Cook University Hospital, Middlesbrough, 
United Kingdom. Email: matbuzz1@hotmail.com
AiP/IP ENTRY DATE
  2018-07-25
FULL RECORD ENTRY DATE
  2018-10-01
SOURCE
  World Neurosurgery (2018) 118 (e161-e165). Date of Publication: 1 Oct 2018
VOLUME
  118
FIRST PAGE
  e161
LAST PAGE
  e165
DATE OF PUBLICATION
  1 Oct 2018
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background: The benefits of early surgical decompression and stabilisation 
(within 24 hours of injury) for patients with acute traumatic spinal cord 
injury (SCI) is unclear. The study objective was to investigate the effects 
of early (<24 hours of injury) versus late (>24 hours of injury) 
decompressive and stabilisation surgery for traumatic cervical SCI in 
patients with concomitant chest injuries. Methods: This was a retrospective 
study including adults aged 16 years or over with traumatic cervical SCI, 
Glasgow Coma Scale score >13, and concomitant chest injuries (e.g. 
hemopneumothoraces, flail chest and pulmonary contusions) necessitating 
intensive care unit (ICU) admission. Forty patients who met the inclusion 
criteria and underwent decompressive surgery within 24 hours were compared 
with 55 patients who underwent decompressive surgery after 24 hours. Primary 
outcomes were ordinal change in the ASIA Impairment Scale (AIS) at 6 months 
and duration of ICU stay. Secondary outcomes included complications 
occurring within 30 days. Results: In the early surgery group, 21 patients 
(52.5%) showed no improvement in ASIA grade, 13 (32.5%) had a 1-grade 
improvement, and 6 (15%) had a 2-grade improvement. The median length of ICU 
stay was 14 days (range, 2–68). 42.5% of patients developed a complication 
and 45% required a tracheostomy. In the late surgery group, AIS grade 
improvement was as follows: 32 (58%) no improvement, 19 (34.5%) had a 1 
grade improvement, 3 (5.5%) had a 2 grade improvement and 1 (2%) had a 3 
grade improvement. Mean ICU stay was 23 days (4–68). 53% of patients 
developed a complication and 55% required a tracheostomy. There was one 
mortality in the late surgery group. Conclusions: For patients with acute 
traumatic cervical SCI and concomitant chest trauma, early surgical 
decompression and stabilisation was associated with reduced ICU stay and a 
lower complication rate. Neurological recovery was more likely in younger 
patients and those with an incomplete SCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); early intervention; spinal cord decompression; spine stabilization; therapy delay; thorax injury; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; American Spinal Injury Association impairment scale; article; assault; clinical outcome; controlled study; decubitus; falling; female; flail chest; Glasgow coma scale; heart disease; hematopneumothorax; human; intensive care unit; length of stay; lung contusion; lung embolism; major clinical study; male; observational study; pneumothorax; postoperative complication; respiratory tract disease; retrospective study; rib fracture; surgical infection; surgical mortality; tracheostomy; traffic accident; treatment failure; ventilator associated pneumonia; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180505925
MEDLINE PMID
  29959069 (http://www.ncbi.nlm.nih.gov/pubmed/29959069)
PUI
  L2000961399
DOI
  10.1016/j.wneu.2018.06.146
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2018.06.146
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2018.06.146&atitle=Results+of+Early+and+Late+Surgical+Decompression+and+Stabilization+for+Acute+Traumatic+Cervical+Spinal+Cord+Injury+in+Patients+with+Concomitant+Chest+Injuries&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=118&issue=&spage=e161&epage=e165&aulast=Sewell&aufirst=Mathew+David&auinit=M.D.&aufull=Sewell+M.D.&coden=&isbn=&pages=e161-e165&date=2018&auinit1=M&auinitm=D
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 55
TITLE
  Combined spinal-epidural and local anesthetic infiltration for cesarean 
delivery in a patient with myotonic dystrophy and severe cardiopulmonary 
compromise
AUTHOR NAMES
  Cai Y.; Scott C.; Anwar A.; James P.; Warrick A.; Vanderhoef K.; Diachun C.
AUTHOR ADDRESSES
  (Cai Y.; Scott C.) Mayo Clinic, Anesthesiology, Jacksonville, United States.
(Anwar A.; James P.; Warrick A.; Vanderhoef K.; Diachun C.) UF Health 
Jacksonville, Anesthesiology, Jacksonville, United States.
CORRESPONDENCE ADDRESS
  Y. Cai, Mayo Clinic, Anesthesiology, Jacksonville, United States.
FULL RECORD ENTRY DATE
  2018-10-08
SOURCE
  Regional Anesthesia and Pain Medicine (2018) 43:7 Supplement 1 (e146). Date 
of Publication: 1 Oct 2018
VOLUME
  43
ISSUE
  7
FIRST PAGE
  e146
DATE OF PUBLICATION
  1 Oct 2018
CONFERENCE NAME
  37th Annual European Society of Regional Anaesthesia and Pain Therapy 
Congress, ESRA 2018
CONFERENCE LOCATION
  Dublin, Ireland
CONFERENCE DATE
  2018-09-12 to 2018-09-15
ISSN
  1532-8651
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background and Aims: Myotonic dystrophy (MD) is a rare disorder 
characterized by progressive myopathy and myotonia. Systemic complications 
may include cardiomyopathy and difficulty weaning from mechanical 
ventilation (MV). Discussion of obstetrical cases in the context of these 
comorbidities are sparse, and to our knowledge, this is the first case of 
regional anesthesia for full-term delivery in a parturient with MD and 
concomitant cardiopulmonary compromise. Methods: Case report. Results: A 
27-year-old G3P0020 at 35w2d with MD and a history of prolonged tracheostomy 
was admitted for progressive hypoxia requiring supplemental oxygen at 25 
weeks gestation. Hospital workup revealed periodic episodes of non-sustained 
ventricular tachycardia and severe right ventricular enlargement with septal 
wall flattening during both systole and diastole. Caesarean section was 
scheduled for 36w2d. Prior to surgery, arterial line and defibrillation pads 
were placed. A combined spinal-epidural (CSE) was placed at L3-4 without 
intrathecal drug administration. Due to incomplete sensory deficit, local 
infiltration using lidocaine was used on skin and uterine incision regions. 
A viable male with APGAR scores of 3 at 1 minute and 7 at 5 minutes was 
delivered at 33 minutes after skin incision. Hemodynamic stability was 
maintained with intravenous epinephrine and vasopressin infusions, and 
spontaneous ventilation was preserved throughout. Conclusions: Given the 
risk of prolonged MV, neuraxial anesthesia was critical to maintaining 
spontaneous respiration. Epidural or intrathecal opioid was avoided due to 
risk of apnea, and intrathecal anesthetic avoided due to sympathectomy. A 
CSE without intrathecal dosing may provide inadequate anesthesia and can be 
supplemented with local infiltration of lidocaine.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  lidocaine; 
EMTREE DRUG INDEX TERMS
  endogenous compound; epinephrine; opiate; oxygen; vasopressin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cesarean section; myotonic dystrophy; 
EMTREE MEDICAL INDEX TERMS
  adult; Apgar score; apnea; arterial line; artificial ventilation; case report; clinical article; comorbidity; conference abstract; defibrillation; diastole; drug combination; drug therapy; female; heart contraction; heart right ventricle hypertrophy; heart ventricle tachycardia; hemodynamics; human; hypoxia; infusion; male; pregnancy; regional anesthesia; sensory dysfunction; skin incision; surgery; sympathectomy; tracheostomy; 
CAS REGISTRY NUMBERS
  epinephrine (51-43-4, 55-31-2, 6912-68-1)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  opiate (53663-61-9, 8002-76-4, 8008-60-4)
  oxygen (7782-44-7)
  vasopressin (11000-17-2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624139955
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15328651&id=doi:&atitle=Combined+spinal-epidural+and+local+anesthetic+infiltration+for+cesarean+delivery+in+a+patient+with+myotonic+dystrophy+and+severe+cardiopulmonary+compromise&stitle=Reg.+Anesth.+Pain+Med.&title=Regional+Anesthesia+and+Pain+Medicine&volume=43&issue=7&spage=e146&epage=&aulast=Cai&aufirst=Y.&auinit=Y.&aufull=Cai+Y.&coden=&isbn=&pages=e146-&date=2018&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 56
TITLE
  The economic burden of spinal muscular atrophy patients in a commercially 
insured population in the united states
AUTHOR NAMES
  Goble J.; Dai D.; Boulos F.; Weng A.; Johnson K.
AUTHOR ADDRESSES
  (Goble J., goble.joseph@gmail.com) Baylor Scott and White Health, One Health 
Plaza, Bldg 125, 2416A, East Hanover, United States.
(Dai D.; Boulos F.; Johnson K.) Novartis Pharmaceuticals, Switzerland.
(Weng A.) KMK Consulting, United States.
CORRESPONDENCE ADDRESS
  J. Goble, Baylor Scott and White Health, One Health Plaza, Bldg 125, 2416A, 
East Hanover, United States. Email: goble.joseph@gmail.com
FULL RECORD ENTRY DATE
  2018-11-02
SOURCE
  Journal of Managed Care and Specialty Pharmacy (2018) 24:10 A (S49). Date of 
Publication: 1 Oct 2018
VOLUME
  24
ISSUE
  10 A
FIRST PAGE
  S49
DATE OF PUBLICATION
  1 Oct 2018
CONFERENCE NAME
  Academy of Managed Care Pharmacy Nexus, AMCP 2018
CONFERENCE LOCATION
  Orlando, FL, United States
CONFERENCE DATE
  2018-10-22 to 2018-10-25
ISSN
  2376-1032
BOOK PUBLISHER
  Academy of Managed Care Pharmacy (AMCP)
ABSTRACT
  BACKGROUND: A high level of burden exists for patients with Spinal Muscular 
Atrophy (SMA) and their caregivers in their journey. In addition to the 
psychosocial impact of the disease, SMA can place a financial burden on 
families and the healthcare system, due to complex care needs requiring a 
spectrum of specialized providers and services. Despite SMA's high clinical 
burden, little information on the economic burden of disease exists. 
OBJECTIVE: To assess the economic burden associated with the treatment of 
SMA patients. METHODS: A retrospective analysis of SMA patients was 
conducted using the MarketScan Commercial and Medicare Supplemental 
Databases (January 2012-November 2017). A cohort of SMA patients identified 
by at least two diagnosis codes (ICD-9: 335.0, 335.1x; ICD-10: G12.0, G12.1, 
G12.8, G12.9) > 30 days apart was assigned to age groups on the index date 
of first SMA claim (< 2 years, 2-18 years, > 18 years). All-cause and 
disease-specific direct healthcare costs and healthcare resource utilization 
[HCRU] (procedures, office visits, durable medical equipment [DME]) were 
derived from the claims databases. Patients were followed from index date 
until the end of continuous enrollment, or the end of the study period, 
whichever occurred earlier. Costs were annualized and adjusted to 2017 U.S. 
dollars. RESULTS: A total of 1,120 patients were identified that met the 
inclusion criteria. The majority of patients were male (51.3%) with a mean 
(SD) age of 33.7 (24.0) years. Mean [SD] all-cause annual direct healthcare 
costs were highest for SMA patients < 2 years old ($159,227 [$313,121]), 
followed by to those 2-18 years ($105,206 [$154,689]) and those > 18 years 
($39,355 [$82,066]). Outpatient medical services were the major driver in 
total healthcare costs, accounting for 52.8% of costs across the entire 
cohort. Disease-specific costs accounted for 49.4% of total costs, which on 
average (SD) totaled $32,332 ($93,687). The majority (87.0%) 68.4%) of 
pediatric patients had home health services while only 68.4% had ≥ 1 office 
visit to a neurologist or pulmonologist. Nearly half (53.3%) of pediatric 
patients had ≥ 1 hospitalizations with a mean (SD) length of stay of 4.7 
(11.3) days. Procedures with the highest utilization across the cohort were 
gastrostomy (21.5%) and tracheostomy (17.8%). DME with frequent use included 
CPAP/BiPAP (28.1%), oxygen machines (25.1%), and suction devices (23.0%). 
CONCLUSIONS: In a commercially insured population, SMA patients had high 
economic burden driven by outpatient medical spend.
EMTREE DRUG INDEX TERMS
  oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; United States; 
EMTREE MEDICAL INDEX TERMS
  adult; ambulatory care; child; cohort analysis; conference abstract; controlled study; diagnosis; driver; gastrostomy; groups by age; hospitalization; human; ICD-10; ICD-9; length of stay; machine; major clinical study; male; medical service; medicare; neurologist; outpatient; pediatric patient; positive end expiratory pressure; pulmonologist; retrospective study; suction pump; tracheostomy; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624641184
DOI
  10.18553/jmcp.2018.24.10-a.s1
FULL TEXT LINK
  http://dx.doi.org/10.18553/jmcp.2018.24.10-a.s1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23761032&id=doi:10.18553%2Fjmcp.2018.24.10-a.s1&atitle=The+economic+burden+of+spinal+muscular+atrophy+patients+in+a+commercially+insured+population+in+the+united+states&stitle=J.++Manag.+Care+Spec.+Pharm.&title=Journal+of+Managed+Care+and+Specialty+Pharmacy&volume=24&issue=10+A&spage=S49&epage=&aulast=Goble&aufirst=J.&auinit=J.&aufull=Goble+J.&coden=&isbn=&pages=S49-&date=2018&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 57
TITLE
  AVXS-101 phase 1 gene therapy clinical trial in spinal muscular atrophy type 
1 (SMA1): Improvement in respiratory and bulbar function reduces frequency 
and duration of hospitalizations compared to natural history
AUTHOR NAMES
  Shell R.; Al-Zaidy S.; Arnold W.; Rodino-Klapac L.; Prior T.; Kotha K.; Paul G.; Lowes L.; Alfano L.; Berry K.; Church K.; Kissel J.; Nagendran S.; Ogrinc F.; Sproule D.
AUTHOR ADDRESSES
  (Shell R.; Al-Zaidy S.; Arnold W.; Rodino-Klapac L.; Prior T.; Kotha K.; 
Paul G.; Lowes L.; Alfano L.; Berry K.; Church K.; Kissel J.; Nagendran S.; 
Ogrinc F.; Sproule D.) Columbus, United States.
CORRESPONDENCE ADDRESS
  R. Shell, Columbus, United States.
FULL RECORD ENTRY DATE
  2018-10-31
SOURCE
  Annals of Neurology (2018) 84 Supplement 22 (S394). Date of Publication: 1 
Oct 2018
VOLUME
  84
FIRST PAGE
  S394
DATE OF PUBLICATION
  1 Oct 2018
CONFERENCE NAME
  47th National Meeting of the Child Neurology Society, CNS 2018
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2018-10-15 to 2018-10-18
ISSN
  1531-8249
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Objective: We report data on requirements for nutritional and ventilatory 
support, and hospitalizations in SMA1 patients treated with AVXS-101, a gene 
replacement therapy. Methods: Twelve patients with SMA1 received a onetime, 
intravenous, proposed therapeutic dose of AVXS-101 (NCT02122952). Results: 
At baseline, 7/12 patients did not require nutritional support, and 10/12 
did not require ventilatory support. As of August 7, 2017, 6/7 patients who 
did not require nutritional support pre-dosing continued to eat exclusively 
by mouth, 11/12 could eat orally, and 7/10 who did not require ventilatory 
support pre-dosing continued without ventilatory support. Ten patients were 
hospitalized for respiratory infections, but all survived without need for 
tracheostomy or permanent ventilation. Patients treated with AVXS-101 spent 
a smaller percentage of time hospitalized (median of 2% [range=0-18.3]) in 
contrast with untreated SMA1 patients in the ENDEAR study (13.9% [0-75]). 
Ten of 12 patients treated with AVXS-101 were hospitalized <10% of the time 
(in contrast with 11/27 untreated patients, ENDEAR), and none were 
hospitalized ≥20% of the time (10/27 untreated patients, ENDEAR). The mean 
unadjusted annualized hospitalization rate (hospitalizations/number of 
subject-years followed) for patients treated with AVXS-101 was 2.0 (standard 
deviation=2.26), which was half that in the ENDEAR control group (4.3). The 
mean hospital stay was 7.1 days (range=3-12.1) in patients treated with 
AVXS-101, compared with 13 days reported in untreated patients. Conclusions: 
In contrast to natural history, SMA1 patients treated with AVXS-101 showed a 
reduced need for nutritional and ventilatory support, and reduced frequency 
and duration of hospitalizations.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  onasemnogene abeparvovec; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gene replacement therapy; genetics; history; hospitalization; rare disease; respiratory function; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; assisted ventilation; clinical article; conference abstract; controlled study; drug therapy; female; human; male; mouth; nutritional support; phase 1 clinical trial; respiratory tract infection; tracheostomy; 
CAS REGISTRY NUMBERS
  onasemnogene abeparvovec (1922968-73-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624589453
DOI
  10.1002/ana.25305
FULL TEXT LINK
  http://dx.doi.org/10.1002/ana.25305
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15318249&id=doi:10.1002%2Fana.25305&atitle=AVXS-101+phase+1+gene+therapy+clinical+trial+in+spinal+muscular+atrophy+type+1+%28SMA1%29%3A+Improvement+in+respiratory+and+bulbar+function+reduces+frequency+and+duration+of+hospitalizations+compared+to+natural+history&stitle=Ann.+Neurol.&title=Annals+of+Neurology&volume=84&issue=&spage=S394&epage=&aulast=Shell&aufirst=R.&auinit=R.&aufull=Shell+R.&coden=&isbn=&pages=S394-&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 58
TITLE
  The four fixation points of the axis: Technique and case report
AUTHOR NAMES
  Siemionow K.; Janusz P.; Mardjetko S.
AUTHOR ADDRESSES
  (Janusz P.) Department of Spine Disorders and Pediatric Orthopedics, 
University of Medical Sciences, Poznan, Poland.
(Mardjetko S.) Illinois Bone and Joint Institute, Chicago, United States.
(Siemionow K., siemiok@gmail.com; Janusz P.) Department of Orthopaedics, 
University of Illinois Medical Center, 835 South Wolcott Ave, Chicago, 
United States.
CORRESPONDENCE ADDRESS
  K. Siemionow, Department of Orthopaedics, University of Illinois Medical 
Center, 835 South Wolcott Ave, Chicago, United States. Email: 
siemiok@gmail.com
AiP/IP ENTRY DATE
  2018-12-04
FULL RECORD ENTRY DATE
  2018-12-10
SOURCE
  International Journal of Spine Surgery (2018) 12:5 (595-602). Date of 
Publication: 1 Oct 2018
VOLUME
  12
ISSUE
  5
FIRST PAGE
  595
LAST PAGE
  602
DATE OF PUBLICATION
  1 Oct 2018
ISSN
  2211-4599 (electronic)
BOOK PUBLISHER
  ISASS, info@ISASS.org
ABSTRACT
  Background: Instrumentation of the axis can be accomplished through a 
variety of techniques including transarticular screw fixation, pars and 
pedicle screw fixation, translaminar screw fixation, and posterior wiring. 
We report on the evolution of the axial 4-screw technique. Methods: 
Retrospective case review. After exposure of posterior spinal elements, the 
medial and superior walls of the C2 pedicle were identified from within the 
spinal canal. A high-speed drill was then advanced under lateral 
fluoroscopy, which guided craniocaudal angulation. Medial angulation was 
based on anatomic landmarks and preoperative imaging. This was followed by 
placement of translaminar screws according to the technique described by 
Wright. When extending the construct into the subaxial spine or the occiput, 
lateral connectors are placed in translaminar screws, which are usually more 
offset. The rod is directly connected to the pedicle screws, which are 
usually more in alignment with the subaxial/occipital instrumentation. 
Results: Two male patients ages 56 and 58 underwent posterior 
instrumentation of the axis employing a combination of pedicle and laminar 
polyaxial screws. Indications included multilevel spinal cord compression 
and deformity in a patient with Down syndrome and cervical meningioma, 
respectively. Follow-up was 1 year and 5 years, respectively. Medical 
complications (N ¼ 2) occurred in the patient with Down syndrome resulting 
in prolonged intubation with tracheostomy placement. Reduction was 
maintained in both patients at last follow-up. There were no neurologic, 
vascular, or instrumentation related complications. Conclusions: The axis 
serves as a versatile anchor point and offers 4 potential points of 
fixation. Lateral connectors play a crucial role and allow for incorporation 
of the C2 screws with the rest of the construct. Local anatomy will dictate 
the necessity and ability to place instrumentation and detailed preoperative 
planning is of paramount importance.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  pedicle screw; spine stabilization; 
EMTREE MEDICAL INDEX TERMS
  adult; article; bone biopsy; bone destruction (diagnosis, surgery); case report; cervical meningioma (diagnosis); cervical spine radiography; clinical article; computer assisted tomography; Down syndrome; endotracheal intubation; follow up; human; human tissue; hypoplasia; long term care; male; meningioma (diagnosis); middle aged; neck pain; pedicle screw fixation device; postoperative complication (complication); priority journal; spinal cord compression (surgery); spinal cord disease; spinal cord lesion (diagnosis, surgery); spine fracture (diagnosis, surgery); spine fusion; spine malformation (surgery); tracheostomy; treatment indication; vertebral canal stenosis; 
DEVICE MANUFACTURERS
   (United States)DePuy Synthes
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180844167
PUI
  L625234352
DOI
  10.14444/5073
FULL TEXT LINK
  http://dx.doi.org/10.14444/5073
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22114599&id=doi:10.14444%2F5073&atitle=The+four+fixation+points+of+the+axis%3A+Technique+and+case+report&stitle=Int.+J.+Spine+Surg.&title=International+Journal+of+Spine+Surgery&volume=12&issue=5&spage=595&epage=602&aulast=Janusz&aufirst=Piotr&auinit=P.&aufull=Janusz+P.&coden=&isbn=&pages=595-602&date=2018&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 59
TITLE
  Nusinersen in infants who initiate treatment in a presymptomatic stage of 
spinal muscular atrophy (SMA): Interim efficacy and safety results from the 
phase 2 nurture study
AUTHOR NAMES
  Crawford T.; De Vivo D.; Bertini E.; Hwu W.L.; Foster R.; Bhan I.; Farwell W.; Reyna S.
AUTHOR ADDRESSES
  (Crawford T.; De Vivo D.; Bertini E.; Hwu W.L.; Foster R.; Bhan I.; Farwell 
W.; Reyna S.) Baltimore, United States.
CORRESPONDENCE ADDRESS
  T. Crawford, Baltimore, United States.
FULL RECORD ENTRY DATE
  2018-10-31
SOURCE
  Annals of Neurology (2018) 84 Supplement 22 (S392). Date of Publication: 1 
Oct 2018
VOLUME
  84
FIRST PAGE
  S392
DATE OF PUBLICATION
  1 Oct 2018
CONFERENCE NAME
  47th National Meeting of the Child Neurology Society, CNS 2018
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2018-10-15 to 2018-10-18
ISSN
  1531-8249
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Objective: NURTURE (NCT02386553) is an ongoing phase 2, open-label, 
single-arm efficacy/safety study of intrathecal nusinersen in infants who 
initiate treatment in a presymptomatic stage of spinal muscular atrophy 
(SMA). Methods: Enrolled infants were age ≤6 weeks at first dose, clinically 
presymptomatic, had genetically diagnosed SMA, and 2 or 3 copies of the SMN2 
gene. The primary endpoint is time to death or respiratory intervention (≥6 
hours/day continuously for ≥7 days or tracheostomy). Results: As of July 5, 
2017, 25 infants (2 copies SMN2, n=15; 3 copies, n=10) were enrolled. Median 
(range) age at last visit was 14.7 (2.8-23.3) months. All infants were 
alive. No infants required tracheostomy or permanent ventilation. Two 
infants had an acute, reversible viral infection requiring respiratory 
intervention and thus met the primary endpoint. Among infants with enough 
observation time, all 22 infants (2 SMN2 copies, n=14; 3 SMN2 copies, n=8) 
had achieved the WHO motor milestone of sitting without support and 8/13 (2 
SMN2 copies, n=3/8; 3 SMN2 copies, n=5/5) had achieved walking alone. AEs 
were reported in 24/25 (96%) infants; most 20/25 (80%) had AEs that were 
mild/moderate in severity; 9 had serious AEs. Four infants had an AE 
possibly related to study drug, which resolved despite continued treatment. 
No new safety concerns were identified. Results from a new interim analysis, 
with an additional 7 months of follow-up, will be presented. Conclusions: 
Nusinersen continued to benefit infants who initiated treatment in a 
presymptomatic stage of SMA, and the updated analyses will provide further 
information.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE DRUG INDEX TERMS
  endogenous compound; survival motor neuron protein 2; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug safety; genetics; neurology; spinal muscular atrophy type 2; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; case report; clinical article; conference abstract; death; diagnosis; drug therapy; female; follow up; human; infant; male; pharmacokinetics; phase 2 clinical trial; tracheostomy; virus infection; walking; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624589373
DOI
  10.1002/ana.25305
FULL TEXT LINK
  http://dx.doi.org/10.1002/ana.25305
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15318249&id=doi:10.1002%2Fana.25305&atitle=Nusinersen+in+infants+who+initiate+treatment+in+a+presymptomatic+stage+of+spinal+muscular+atrophy+%28SMA%29%3A+Interim+efficacy+and+safety+results+from+the+phase+2+nurture+study&stitle=Ann.+Neurol.&title=Annals+of+Neurology&volume=84&issue=&spage=S392&epage=&aulast=Crawford&aufirst=T.&auinit=T.&aufull=Crawford+T.&coden=&isbn=&pages=S392-&date=2018&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 60
TITLE
  Development of acute promyelocytic leukemia in a patient with tetraplegia 
while in inpatient rehabilitation: A case report
AUTHOR NAMES
  Beal C.A.; Krouse M.C.; Tubbs J.T.
AUTHOR ADDRESSES
  (Beal C.A., Christopher.beal@vcuhealth.org; Tubbs J.T.) Spinal Cord Injury 
Service and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, 
United States.
(Beal C.A., Christopher.beal@vcuhealth.org; Tubbs J.T.) Department of 
Physical Medicine and Rehabilitation, Virginia Commonwealth University, 
Richmond, United States.
(Krouse M.C.) School of Medicine, Virginia Commonwealth University, 
Richmond, United States.
CORRESPONDENCE ADDRESS
  C.A. Beal, Virginia Commonwealth University Health System, Department of 
Physical Medicine and Rehabilitation, DO, Resident Physician, 1223 E. 
Marshall St., P.O. Box 980677, Richmond, United States. Email: 
Christopher.beal@vcuhealth.org
AiP/IP ENTRY DATE
  2017-09-27
FULL RECORD ENTRY DATE
  2018-09-04
SOURCE
  Journal of Spinal Cord Medicine (2018) 41:5 (571-574). Date of Publication: 
3 Sep 2018
VOLUME
  41
ISSUE
  5
FIRST PAGE
  571
LAST PAGE
  574
DATE OF PUBLICATION
  3 Sep 2018
ISSN
  2045-7723 (electronic)
  1079-0268
BOOK PUBLISHER
  Taylor and Francis Ltd., michael.wagreich@univie.ac.at
ABSTRACT
  Study Design: a single case report. Objectives: To report a case of a 
patient with tetraplegia who developed acute promyelocytic leukemia (APL) 
while in inpatient rehabilitation after 10.5 months. Setting: A VA Medical 
Center Spinal Cord Injury Service and Disorders Unit Case Report: A 47 
year-old male with a stage IV sacral pressure ulcer and C4 AIS A complete 
tetraplegia secondary to a motor vehicle collision, developed fever, 
thrombocytopenia, and anemia 20 months after his injury while in inpatient 
rehabilitation and was found to have APL, confirmed following bone marrow 
biopsy. Conclusion: There is a wide differential for fever after a spinal 
cord injury. In this case report, the source of fever was APL. It is 
important as healthcare providers to not overlook fevers when otherwise 
common causes do not fit the clinical picture. Additionally, there has been 
no association found between traumatic spinal cord injury and the 
development of acute leukemia, however this is the first case report. 
Therefore, it is important to continue investigating to determine if an 
association exists.
EMTREE DRUG INDEX TERMS
  arsenic trioxide (drug therapy); enoxaparin; ertapenem (drug therapy); hemoglobin (endogenous compound); piperacillin plus tazobactam (drug therapy); retinoic acid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  promyelocytic leukemia (diagnosis, drug therapy); quadriplegia (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; anemia; article; blast cell; blood cell count; blood culture; bone marrow biopsy; case report; Caucasian; cervical spine fracture; clinical article; decubitus (surgery); dysphagia; febrile neutropenia; fever; gluteus muscle; hemoglobin blood level; hospital patient; human; intensive care; Klebsiella infection; laboratory test; leukemia remission; leukocyte count; male; middle aged; muscle flap; percutaneous endoscopic gastrostomy; Proteus infection (drug therapy); Proteus mirabilis; rehabilitation care; sacral vertebra; thrombocytopenia; tracheostomy; traffic accident; urinary tract infection (drug therapy); wound dehiscence; 
CAS REGISTRY NUMBERS
  arsenic trioxide (1303-24-8, 1327-53-3, 13464-58-9, 15502-74-6)
  enoxaparin (679809-58-6)
  ertapenem (153773-82-1, 153832-38-3, 153832-46-3)
  hemoglobin (9008-02-0)
  retinoic acid (302-79-4)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Hematology (25)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170672005
PUI
  L618427740
DOI
  10.1080/10790268.2017.1375722
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2017.1375722
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2017.1375722&atitle=Development+of+acute+promyelocytic+leukemia+in+a+patient+with+tetraplegia+while+in+inpatient+rehabilitation%3A+A+case+report&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=41&issue=5&spage=571&epage=574&aulast=Beal&aufirst=Christopher+A.&auinit=C.A.&aufull=Beal+C.A.&coden=JSCMC&isbn=&pages=571-574&date=2018&auinit1=C&auinitm=A
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 61
TITLE
  Predictive values of magnetic resonance imaging features for tracheostomy in 
traumatic cervical spinal cord injury
AUTHOR NAMES
  Jeong T.S.; Lee S.G.; Kim W.K.; Ahn Y.; Son S.
AUTHOR ADDRESSES
  (Jeong T.S.; Lee S.G., samddal@gilhospital.com; Kim W.K.; Ahn Y.; Son S.) 
Department of Neurosurgery, Gil Medical Center, Gachon University College of 
Medicine, Incheon, South Korea.
CORRESPONDENCE ADDRESS
  S.G. Lee, Department of Neurosurgery, Gachon University Gil Medical Center, 
21 Namdong-daero 774beon-gil, Namdong-gu, Incheon, South Korea. Email: 
samddal@gilhospital.com
AiP/IP ENTRY DATE
  2018-11-22
FULL RECORD ENTRY DATE
  2018-11-27
SOURCE
  Journal of Korean Neurosurgical Society (2018) 61:5 (582-591). Date of 
Publication: 1 Sep 2018
VOLUME
  61
ISSUE
  5
FIRST PAGE
  582
LAST PAGE
  591
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  1598-7876 (electronic)
  2005-3711
BOOK PUBLISHER
  Korean Neurosurgical Society
ABSTRACT
  Objective: To evaluate the magnetic resonance (MR) imaging features that 
have a statistically significant association with the need for a 
tracheostomy in patients with cervical spinal cord injury (SCI) during the 
acute stage of injury. Methods: This study retrospectively reviewed the 
clinical data of 130 patients with cervical SCI. We analyzed the factors 
believed to increase the risk of requiring a tracheostomy, including the 
severity of SCI, the level of injury as determined by radiological 
assessment, three quantitative MR imaging parameters, and eleven qualitative 
MR imaging parameters. Results: Significant differences between the 
non-tracheostomy and tracheostomy groups were determined by the following 
five factors on multivariate analysis: complete SCI (p=0.007), the 
radiological level of C5 and above (p=0.038), maximum canal compromise (MCC) 
(p=0.010), lesion length (p=0.022), and osteophyte formation (p=0.015). For 
the MCC, the cut-off value was 46%, and the risk of requiring a tracheostomy 
was three times higher at an interval between 50–60% and ten times higher 
between 60–70%. For lesion length, the cut-off value was 20 mm, and the risk 
of requiring a tracheostomy was two times higher at an interval between 
20–30 mm and fourteen times higher between 40–50 mm. Conclusion: The 
American Spinal Injury Association grade A, a radiological injury level of 
C5 and above, an MCC ≥50%, a lesion length ≥20 mm, and osteophyte formation 
at the level of injury were considered to be predictive values for requiring 
tracheostomy intervention in patients with cervical SCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (diagnosis); nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; predictive value; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cervical spine dislocation; data analysis; female; human; intubation; major clinical study; male; middle aged; osteophyte; retrospective study; spinal cord; spinal cord compression; vertebra dislocation; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Arthritis and Rheumatism (31)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180812245
PUI
  L624873053
DOI
  10.3340/jkns.2017.0222
FULL TEXT LINK
  http://dx.doi.org/10.3340/jkns.2017.0222
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15987876&id=doi:10.3340%2Fjkns.2017.0222&atitle=Predictive+values+of+magnetic+resonance+imaging+features+for+tracheostomy+in+traumatic+cervical+spinal+cord+injury&stitle=J.+Korean+Neurosurg.+Soc.&title=Journal+of+Korean+Neurosurgical+Society&volume=61&issue=5&spage=582&epage=591&aulast=Jeong&aufirst=Tae+Seok&auinit=T.S.&aufull=Jeong+T.S.&coden=&isbn=&pages=582-591&date=2018&auinit1=T&auinitm=S
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 62
TITLE
  Risk factors of nosocomial pneumonia in multiple trauma patients
AUTHOR NAMES
  Kahloul M.; Jebali C.; Chrigui R.; Aissa S.; Chouchane S.; Chaabani M.; Nakhli M.S.; Naija W.
AUTHOR ADDRESSES
  (Kahloul M.; Chrigui R.; Chouchane S.; Chaabani M.; Nakhli M.S.; Naija W.) 
Department of Anesthesia and Intensive Care, Sahloul Teaching Hospital, 
Sousse, Tunisia.
(Jebali C.) Emergency Medical Service, Sousse, Tunisia.
(Aissa S.) Department of Pneumology, FH Teaching Hospital, Sousse, Tunisia.
CORRESPONDENCE ADDRESS
  M. Kahloul, Department of Anesthesia and Intensive Care, Sahloul Teaching 
Hospital, Sousse, Tunisia.
FULL RECORD ENTRY DATE
  2019-03-11
SOURCE
  European Respiratory Journal (2018) 52 Supplement 62. Date of Publication: 1 
Sep 2018
VOLUME
  52
DATE OF PUBLICATION
  1 Sep 2018
CONFERENCE NAME
  European Respiratory Society International Congress, ERS 2018
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2018-09-15 to 2018-09-19
ISSN
  1399-3003
BOOK PUBLISHER
  European Respiratory Society
ABSTRACT
  Introduction: Nosocomial pulmonary infections are a major health problem 
mainly in trauma intensive care units (TICU) because of their important 
incidence, high mortality and hudge cost. Aim: Establish epidemiological 
characteristics of nosocomial pneumonia in multiple trauma patients and to 
identify their risk factors. Methods: This is an observational, descriptive 
and retrospective study conducted in a Tunisian TICU. All multiple trauma 
patients hospitalized between January 2013 and December 2014 were enrolled. 
Inclusion criteria were hospital length of stay ≥ 48 hours and an injury 
severity scale ≥ 16. Collected data included patients demographics 
characteristics, traumatic lesions severity, duration of invasive devices 
and infectious related parameters. Results: During the study period, 154 
patients were included. Average age was 37.61 years. Sex ratio was 5.16. 
Nosocomial pneumonia incidence was 35.7%. Main involved bacteria were 
enterobacteria in 23.6% of cases (half of them were sensitive to 
third-generation cephalosporins), Staphylococcus aureus in 21.8% of cases 
(half of them were methicillin resistant), pseudomonas aeruginosa in 20% of 
cases (27.2% of them were resistant to ceftazidime). Risk factors found in 
univariate analysis were severe brain injury, cervical spine injury, 
nasogastric tube, tracheostomy, proton pomp inhibitor administration, 
enteral nutrition and APACHE II score. Risk factors found in multi variate 
analysis were mechanical ventilation >10 days and naso-gastric tube 
insertion. Conclusion: Nosocomial pneumonia is a serious problem in TICU. 
Reduction of mechanical ventilation duration and a rapid removal of invasive 
devices are the main preventive measures.
EMTREE DRUG INDEX TERMS
  ceftazidime; meticillin; nutrition supplement; proton; unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  multiple trauma; pneumonia; risk assessment; risk factor; 
EMTREE MEDICAL INDEX TERMS
  adult; APACHE; artificial ventilation; brain injury; cervical spine injury; conference abstract; controlled study; drug resistance; Enterobacteriaceae; female; human; incidence; injury severity; intensive care unit; length of stay; lung infection; major clinical study; male; nasogastric tube; nonhuman; Pseudomonas aeruginosa; retrospective study; sex ratio; Staphylococcus aureus; tracheostomy; univariate analysis; 
CAS REGISTRY NUMBERS
  ceftazidime (72558-82-8)
  meticillin (132-92-3, 38882-79-0, 61-32-5)
  proton (12408-02-5, 12586-59-3)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L626624790
DOI
  10.1183/13993003.congress-2018.PA2642
FULL TEXT LINK
  http://dx.doi.org/10.1183/13993003.congress-2018.PA2642
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13993003&id=doi:10.1183%2F13993003.congress-2018.PA2642&atitle=Risk+factors+of+nosocomial+pneumonia+in+multiple+trauma+patients&stitle=Eur.+Respir.+J.&title=European+Respiratory+Journal&volume=52&issue=&spage=&epage=&aulast=Kahloul&aufirst=Mohamed&auinit=M.&aufull=Kahloul+M.&coden=&isbn=&pages=-&date=2018&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 63
TITLE
  Changing respiratory expectations with the new disease trajectory of 
nusinersen treated spinal muscular atrophy [SMA] type 1
AUTHOR NAMES
  Fitzgerald D.A.; Doumit M.; Abel F.
AUTHOR ADDRESSES
  (Fitzgerald D.A., dominic.fitzgerald@health.nsw.gov.au) Department of 
Respiratory Medicine, The Children's Hospital at Westmead, Sydney, 
Australia.
(Fitzgerald D.A., dominic.fitzgerald@health.nsw.gov.au) Discipline of Child 
and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, 
Australia.
(Doumit M.) Department of Physiotherapy, Sydney Children's Hospital, 
Randwick, Sydney, Australia.
(Doumit M.) School of Women's and Children's Health, University of New South 
Wales, Sydney, Australia.
(Abel F.) Department of Respiratory Medicine, Great Ormond Street Hospital, 
London, United Kingdom.
CORRESPONDENCE ADDRESS
  D.A. Fitzgerald, Paediatric Respiratory and Sleep Physician, The Children's 
Hospital at Westmead, Locked Bag 4001, Westmead, , Australia. Email: 
dominic.fitzgerald@health.nsw.gov.au
AiP/IP ENTRY DATE
  2018-11-12
FULL RECORD ENTRY DATE
  2019-04-19
SOURCE
  Paediatric Respiratory Reviews (2018) 28 (11-17). Date of Publication: 1 Sep 
2018
VOLUME
  28
FIRST PAGE
  11
LAST PAGE
  17
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  1526-0550 (electronic)
  1526-0542
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Spinal muscular atrophy [SMA] is the most common genetic cause of childhood 
mortality, primarily from the most severe form SMA type 1. It is a severe, 
progressive motor neurone disease, affecting the lower brainstem nuclei and 
the spinal cord. There is a graded level of severity with SMA children from 
a practical viewpoint described as “Non-sitters”, “Sitters” and less 
commonly, “Ambulant” correlating with SMA Type 0/Type 1, Type 2 and Type 3 
respectively. Children with SMA Type 0 have a severe neonatal form whilst 
those with SMA Type 1 develop hypoventilation, pulmonary aspiration, 
recurrent lower respiratory tract infections, dysphagia and failure to 
thrive before usually succumbing to respiratory failure and death before the 
age of 2 years. The recent introduction of the antisense oligonucleotide 
nusinersen into clinical practice in certain countries, following limited 
trials of less than two years duration, has altered the treatment landscape 
and improved the outlook considerably for SMN1 related SMA. Approximately 
70% of infants appear to have a clinically significant response to 
nusinersen with improved motor function. It appears the earlier the 
treatment is initiated the better the response. There are other rarer 
genetic forms of SMA that are not treated with nusinersen. Clinical 
expectations will change although it is unclear as yet what the extent of 
response will mean in terms of screening initiatives [e.g., newborn 
screening], “preventative strategies” to maintain respiratory wellbeing, 
timing of introduction of respiratory supports, and prolonged life 
expectancy for the subcategory of children with treated SMA type 1. This 
article provides a review of the strategies available for supporting 
children with respiratory complications of SMA, with a particular emphasis 
on SMA Type 1.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen (drug therapy, intrathecal drug administration, pharmacology); 
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); bronchodilating agent (drug therapy); ipratropium bromide (drug therapy); Pneumococcus vaccine (drug therapy); survival motor neuron protein 1 (drug therapy, endogenous compound, 
intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory tract disease (complication, therapy); Werdnig Hoffmann disease (drug therapy, etiology); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; breathing exercise; bronchiolitis (complication); coughing (complication, drug therapy, therapy); disease course; disease severity; drug mechanism; evidence based medicine; forced expiratory volume; gastroesophageal reflux (complication); gene therapy; genetic association; human; hypoventilation (complication); loss of function mutation; lower respiratory tract infection (complication); lung compliance; maximal expiratory flow; molecular pathology; mucociliary clearance; nonhuman; outcome assessment; phenotypic variation; pneumococcal infection (complication, drug therapy, prevention); priority journal; pulmonary aspiration (complication, drug therapy, prevention); quality of life; respiratory failure (complication, therapy); review; single drug dose; therapy effect; tracheostomy; treatment duration; 
CAS REGISTRY NUMBERS
  ipratropium bromide (22254-24-6)
  nusinersen (1258984-36-9)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Anesthesiology (24)
  Clinical and Experimental Pharmacology (30)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30414815 (http://www.ncbi.nlm.nih.gov/pubmed/30414815)
PUI
  L2001251683
DOI
  10.1016/j.prrv.2018.07.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.prrv.2018.07.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15260550&id=doi:10.1016%2Fj.prrv.2018.07.002&atitle=Changing+respiratory+expectations+with+the+new+disease+trajectory+of+nusinersen+treated+spinal+muscular+atrophy+%5BSMA%5D+type+1&stitle=Paediatr.+Respir.+Rev.&title=Paediatric+Respiratory+Reviews&volume=28&issue=&spage=11&epage=17&aulast=Fitzgerald&aufirst=Dominic+A.&auinit=D.A.&aufull=Fitzgerald+D.A.&coden=PRRAE&isbn=&pages=11-17&date=2018&auinit1=D&auinitm=A
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 64
TITLE
  Timing of Tracheostomy Procedures in Patients with Spinal Cord Injury 
Requiring Cervical Spine Surgery: Is Early Tracheostomy Really Associated 
with Fewer Wound Infections?
AUTHOR NAMES
  Agarwal N.; Agrawal M.; Sawarkar D.P.
AUTHOR ADDRESSES
  (Agarwal N.; Agrawal M.; Sawarkar D.P., dattaraja@gmail.com) Department of 
Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
CORRESPONDENCE ADDRESS
  D.P. Sawarkar, Department of Neurosurgery, All India Institute of Medical 
Sciences, New Delhi, India. Email: dattaraja@gmail.com
AiP/IP ENTRY DATE
  2018-07-03
FULL RECORD ENTRY DATE
  2018-09-03
SOURCE
  World Neurosurgery (2018) 117 (469). Date of Publication: 1 Sep 2018
VOLUME
  117
FIRST PAGE
  469
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; spine surgery; surgical infection (complication); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  human; infection risk; intensive care unit; lower respiratory tract; microbial colonization; note; patient positioning; treatment outcome; weakness; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180456441
MEDLINE PMID
  30149431 (http://www.ncbi.nlm.nih.gov/pubmed/30149431)
PUI
  L2000893748
DOI
  10.1016/j.wneu.2018.05.204
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2018.05.204
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2018.05.204&atitle=Timing+of+Tracheostomy+Procedures+in+Patients+with+Spinal+Cord+Injury+Requiring+Cervical+Spine+Surgery%3A+Is+Early+Tracheostomy+Really+Associated+with+Fewer+Wound+Infections%3F&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=117&issue=&spage=469&epage=&aulast=Agarwal&aufirst=Nitish&auinit=N.&aufull=Agarwal+N.&coden=&isbn=&pages=469-&date=2018&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 65
TITLE
  In Reply to “Timing of Tracheostomy Procedures in Patients with Spinal Cord 
Injury Requiring Cervical Spine Surgery: Is Early Tracheostomy Really 
Associated with Fewer Wound Infections?”
AUTHOR NAMES
  Galeiras R.; Mourelo-Fariña M.; Bouza M.T.; Seoane M.T.; Ferreiro M.E.; Montoto A.; Salvador S.; Seoane L.
AUTHOR ADDRESSES
  (Galeiras R.; Mourelo-Fariña M., monica.mourelo@gmail.com; Bouza M.T.; 
Seoane L.) Department of Critical Care, Complexo University Hospital of A 
Coruña, SERGAS, Biomedical Research Institute of A Coruña, University of A 
Coruña, A Coruña, Spain.
(Seoane M.T.) Clinical Epidemiology and Biostatistics, Complexo University 
Hospital of A Coruña, SERGAS, Biomedical Research Institute of A Coruña, 
University of A Coruña, A Coruña, Spain.
(Ferreiro M.E.; Montoto A.; Salvador S.) Department Spinal Cord Injury, 
Complexo University Hospital of A Coruña, SERGAS, Biomedical Research 
Institute of A Coruña, University of A Coruña, A Coruña, Spain.
CORRESPONDENCE ADDRESS
  M. Mourelo-Fariña, Department of Critical Care, Complexo University Hospital 
of A Coruña, SERGAS, Biomedical Research Institute of A Coruña, University 
of A Coruña, A Coruña, Spain. Email: monica.mourelo@gmail.com
AiP/IP ENTRY DATE
  2018-08-28
FULL RECORD ENTRY DATE
  2018-09-03
SOURCE
  World Neurosurgery (2018) 117 (470). Date of Publication: 1 Sep 2018
VOLUME
  117
FIRST PAGE
  470
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  early intervention; operation duration; postoperative infection (complication); spine surgery; tracheostomy; wound infection (complication); 
EMTREE MEDICAL INDEX TERMS
  antibiotic therapy; artificial ventilation; cervical spinal cord injury; human; note; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180579366
MEDLINE PMID
  30149432 (http://www.ncbi.nlm.nih.gov/pubmed/30149432)
PUI
  L2000939460
DOI
  10.1016/j.wneu.2018.06.107
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2018.06.107
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2018.06.107&atitle=In+Reply+to+%E2%80%9CTiming+of+Tracheostomy+Procedures+in+Patients+with+Spinal+Cord+Injury+Requiring+Cervical+Spine+Surgery%3A+Is+Early+Tracheostomy+Really+Associated+with+Fewer+Wound+Infections%3F%E2%80%9D&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=117&issue=&spage=470&epage=&aulast=Galeiras&aufirst=Rita&auinit=R.&aufull=Galeiras+R.&coden=&isbn=&pages=470-&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 66
TITLE
  Spinal cord injury-induced heterotopic calcification on a balloon of a Foley 
catheter
AUTHOR NAMES
  Inamasu J.; Hirose Y.; Nakatsukasa M.
AUTHOR ADDRESSES
  (Inamasu J., inamasu@fujita-hu.ac.jp; Hirose Y.) Department of Neurosurgery, 
Fujita Health University Hospital, Toyoake, Japan.
(Inamasu J., inamasu@fujita-hu.ac.jp; Nakatsukasa M.) Department of 
Neurosurgery, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan.
CORRESPONDENCE ADDRESS
  J. Inamasu, Department of Neurosurgery, Fujita Health University Hospital, 
Toyoake, Japan. Email: inamasu@fujita-hu.ac.jp
AiP/IP ENTRY DATE
  2018-08-01
FULL RECORD ENTRY DATE
  2018-09-14
SOURCE
  Neurology and Clinical Neuroscience (2018) 6:5 (155). Date of Publication: 1 
Sep 2018
VOLUME
  6
ISSUE
  5
FIRST PAGE
  155
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  2049-4173 (electronic)
BOOK PUBLISHER
  Blackwell Publishing Ltd
EMTREE DRUG INDEX TERMS
  calcium oxalate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone mineralization; Foley balloon catheter; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; clinical article; cystoscopy; human; male; micturition; priority journal; tracheostomy; urinary tract obstruction; young adult; 
CAS REGISTRY NUMBERS
  calcium oxalate (563-72-4)
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180523920
PUI
  L623247847
DOI
  10.1111/ncn3.12217
FULL TEXT LINK
  http://dx.doi.org/10.1111/ncn3.12217
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20494173&id=doi:10.1111%2Fncn3.12217&atitle=Spinal+cord+injury-induced+heterotopic+calcification+on+a+balloon+of+a+Foley+catheter&stitle=Neurol.+Clin.+Neurosci.&title=Neurology+and+Clinical+Neuroscience&volume=6&issue=5&spage=155&epage=&aulast=Inamasu&aufirst=Joji&auinit=J.&aufull=Inamasu+J.&coden=&isbn=&pages=155-&date=2018&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 67
TITLE
  Urgent Endovascular Treatment for Non-traumatic Descending Thoracic Aortic 
Rupture
AUTHOR NAMES
  Thomas R.P.; Amin S.S.; Eldergash O.; Kowald T.; Bremer S.; Easo J.; Weymann A.; Book M.; Szczechowicz M.; Schmuck B.; Chavan A.
AUTHOR ADDRESSES
  (Thomas R.P., rohit0904@gmail.com; Amin S.S.; Eldergash O.; Kowald T.; 
Bremer S.; Schmuck B.; Chavan A.) Institute of Diagnostic and Interventional 
Radiology, Klinikum Oldenburg AöR, Rahel Straus Strasse 10, Oldenburg, 
Germany.
(Easo J.; Weymann A.; Szczechowicz M.) Department of Cardiac Surgery, 
University Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany.
(Book M.) Department of Anesthesia, Intensive Care Medicine, Emergency 
Medicine and Pain Therapy, University Hospital, Klinikum Oldenburg AöR, 
Oldenburg, Germany.
CORRESPONDENCE ADDRESS
  R.P. Thomas, Institute of Diagnostic and Interventional Radiology, Klinikum 
Oldenburg AöR, Rahel Straus Strasse 10, Oldenburg, Germany. Email: 
rohit0904@gmail.com
AiP/IP ENTRY DATE
  2018-06-19
FULL RECORD ENTRY DATE
  2018-11-20
SOURCE
  CardioVascular and Interventional Radiology (2018) 41:9 (1318-1323). Date of 
Publication: 1 Sep 2018
VOLUME
  41
ISSUE
  9
FIRST PAGE
  1318
LAST PAGE
  1323
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  1432-086X (electronic)
  0174-1551
BOOK PUBLISHER
  Springer New York LLC, barbara.b.bertram@gsk.com
ABSTRACT
  Purpose: To evaluate the efficacy of endovascular repair of non-traumatic 
rupture of the descending thoracic aorta. Materials and Methods: From 
January 2011 to August 2017, 22 consecutive patients (16 men, mean age 
73.7 years, range 63–92 years) with non-traumatic rupture of the descending 
thoracic aorta were treated endovascularly. Thirty-day mortality as well as 
procedure-related morbidity including stroke, renal, pulmonary and spinal 
complications were retrospectively assessed. Median follow-up was 29 months 
(range 6–65 months). Results: Nine patients had type B dissections, and 13 
had atherosclerotic aortic aneurysms. The technical success was 100%; 86.3% 
of patients (19/22) were treated percutaneously. Thirteen patients (59%) 
received a single endograft, 8 (36%) received 2 endografts, and 1 received 3 
endografts. The endograft diameters ranged between 28 and 46 mm. Two 
dissection patients received additional distal bare metal true lumen stents. 
Eleven patients required additional drainage of thoracic hematoma. Three 
primary percutaneous sites (15.7%) required surgical revision. No spinal 
cord ischemic or renal complications were observed. Stroke was observed in 2 
patients (9%), both with full coverage of left subclavian artery origin. 
Four patients (18%) required tracheostomy with prolonged respiratory support 
(range 10–15 days). The median intensive care unit stay was 5 days (range 
1–27 days). The 30-day mortality was 18.1% (4/22). Conclusion: Endoluminal 
repair of non-traumatic rupture of the descending thoracic aorta can be 
performed percutaneously. It showed a 30-day mortality of 18.1%, and no 
spinal cord injury or renal complications were observed in surviving 
patients at follow-up. Level of Evidence: Level 4, case series.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  descending aorta; endovascular aneurysm repair; thoracic aorta aneurysm (epidemiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; angiocardiography; angiography device; aortic aneurysm endovascular graft; aortic atherosclerosis; aortic dissection (surgery); article; assisted ventilation; Back-up Meier; bare metal stent; bare metal stenting; catheter sheath; cerebrovascular accident (complication); clinical article; cohort analysis; controlled study; diagnostic catheter; drainage catheter; Evita E-XL; female; follow up; hematothorax (complication); human; incidence; left subclavian artery; length of stay; Lunderquist; male; morbidity; mortality rate; percutaneous drainage; priority journal; Prostar XL; respiratory failure (complication, surgery); retrospective study; surgical mortality; survival rate; thorax drainage; tracheostomy; Valiant Captivia; vascular closure device; vascular guide wire; X ray system; 
DEVICE TRADE NAMES
  Axiom Artis  Siemens

  Back-up Meier  , United StatesBoston Scientific

  Evita E-XL  , GermanyJotec

  Lunderquist  , DenmarkCook Medical

  Prostar XL  , United StatesAbbott Vascular

  Valiant Captivia  , United StatesMedtronic Vascular

DEVICE MANUFACTURERS
   (Germany)Jotec
   (Denmark)Cook Medical
   (United States)Abbott Vascular
   (United States)Boston Scientific
   (United States)Medtronic Vascular
  Siemens
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180417169
MEDLINE PMID
  29948006 (http://www.ncbi.nlm.nih.gov/pubmed/29948006)
PUI
  L622556698
DOI
  10.1007/s00270-018-2006-0
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00270-018-2006-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1432086X&id=doi:10.1007%2Fs00270-018-2006-0&atitle=Urgent+Endovascular+Treatment+for+Non-traumatic+Descending+Thoracic+Aortic+Rupture&stitle=Cardiovasc.+Intervent.+Radiol.&title=CardioVascular+and+Interventional+Radiology&volume=41&issue=9&spage=1318&epage=1323&aulast=Thomas&aufirst=Rohit+Philip&auinit=R.P.&aufull=Thomas+R.P.&coden=CARAD&isbn=&pages=1318-1323&date=2018&auinit1=R&auinitm=P
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 68
TITLE
  The role of sleep diagnostics and non-invasive ventilation in children with 
spinal muscular atrophy
AUTHOR NAMES
  Grychtol R.; Abel F.; Fitzgerald D.A.
AUTHOR ADDRESSES
  (Grychtol R.; Abel F., francois.abel@gosh.nhs.uk) Department of Respiratory 
Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, 
London, United Kingdom.
(Fitzgerald D.A.) Department of Respiratory Medicine, The Children's 
Hospital at Westmead, Sydney, Australia.
(Fitzgerald D.A.) Discipline of Child and Adolescent Health, Sydney Medical 
School, University of Sydney, Sydney, Australia.
CORRESPONDENCE ADDRESS
  F. Abel, Paediatric Respiratory and Sleep Physician, Great Ormond Street 
Hospital for Children NHS Foundation Trust, Great Ormond Street, London, 
United Kingdom. Email: francois.abel@gosh.nhs.uk
AiP/IP ENTRY DATE
  2018-11-07
FULL RECORD ENTRY DATE
  2019-04-19
SOURCE
  Paediatric Respiratory Reviews (2018) 28 (18-25). Date of Publication: 1 Sep 
2018
VOLUME
  28
FIRST PAGE
  18
LAST PAGE
  25
DATE OF PUBLICATION
  1 Sep 2018
ISSN
  1526-0550 (electronic)
  1526-0542
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Spinal muscular atrophy (SMA) is a degenerative motor neurone disorder 
causing progressive muscular weakness. Without assisted ventilation or novel 
therapies, most children with SMA type 1 die before the second year of life 
due to respiratory failure as the respiratory muscles and bulbar function 
are severely affected. Active respiratory treatment (mechanically assisted 
cough, invasive or non-invasive ventilation) has improved survival 
significantly in recent decades, but often at the cost of becoming 
ventilator dependent. The advent of a new oligonucleotide based therapy 
(Nusinersen) has created new optimism for improving motor function. However, 
the long-term effect on respiratory function is unclear and non-invasive 
respiratory support will remain an important part of medical management in 
patients with SMA. This review summarises the existing knowledge about 
sleep-disordered breathing and respiratory failure in patients with SMA, 
especially type 1, as well as the evidence of improved outcome and survival 
in patients treated with non-invasive or invasive ventilation. Practical 
considerations and ethical concerns are delineated with discussion on how 
these may be affected by the advent of new therapies such as Nusinersen.
EMTREE DRUG INDEX TERMS
  nusinersen (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  noninvasive ventilation; respiratory failure (diagnosis, etiology, therapy); sleep disordered breathing (etiology, therapy); Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; child; disease severity; human; medical ethics; pathophysiology; practice guideline; priority journal; prognosis; review; spinal muscular atrophy (drug therapy); survival rate; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30396824 (http://www.ncbi.nlm.nih.gov/pubmed/30396824)
PUI
  L2001239872
DOI
  10.1016/j.prrv.2018.07.006
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.prrv.2018.07.006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15260550&id=doi:10.1016%2Fj.prrv.2018.07.006&atitle=The+role+of+sleep+diagnostics+and+non-invasive+ventilation+in+children+with+spinal+muscular+atrophy&stitle=Paediatr.+Respir.+Rev.&title=Paediatric+Respiratory+Reviews&volume=28&issue=&spage=18&epage=25&aulast=Grychtol&aufirst=Ruth&auinit=R.&aufull=Grychtol+R.&coden=PRRAE&isbn=&pages=18-25&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 69
TITLE
  Section 7: Spinal muscular atrophy and home ventilation
AUTHOR NAMES
  Thavagnanam S.; Chiang J.; Zielinski D.; Amin R.
AUTHOR ADDRESSES
  (Thavagnanam S., Sthava@hotmail.com) Division of Paediatric Respiratory 
Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
(Chiang J.) Division of Complex Continuing Care, Holland Bloorview Kids 
Rehabilitation Hospital, Toronto, Canada.
(Zielinski D.) Division of Respiratory Medicine, Montreal Children’s 
Hospital, Montreal, Canada.
(Amin R.) University of Toronto, Toronto, Canada.
(Amin R.) Division of Respiratory Medicine, The Hospital for Sick Children, 
Toronto, Canada.
CORRESPONDENCE ADDRESS
  S. Thavagnanam, Flat 4, 306 Finchley Road, London, United Kingdom. Email: 
Sthava@hotmail.com
AiP/IP ENTRY DATE
  2018-11-02
FULL RECORD ENTRY DATE
  2018-11-08
SOURCE
  Canadian Journal of Respiratory, Critical Care, and Sleep Medicine (2018) 
2:sup1 (53-59). Date of Publication: 16 Aug 2018
VOLUME
  2
ISSUE
  sup1
FIRST PAGE
  53
LAST PAGE
  59
DATE OF PUBLICATION
  16 Aug 2018
ISSN
  2474-5340 (electronic)
  2474-5332
BOOK PUBLISHER
  Taylor and Francis Inc., customerservice@taylorandfrancis.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; home care; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  acute disease; article; human; information retrieval; Medline; noninvasive ventilation; palliative therapy; priority journal; prophylaxis; publication; scoliosis; spine surgery; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180762501
PUI
  L624639082
DOI
  10.1080/24745332.2018.1494981
FULL TEXT LINK
  http://dx.doi.org/10.1080/24745332.2018.1494981
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=24745340&id=doi:10.1080%2F24745332.2018.1494981&atitle=Section+7%3A+Spinal+muscular+atrophy+and+home+ventilation&stitle=Can.+J.+Respir.+Crit.+Care++Sleep+Med.&title=Canadian+Journal+of+Respiratory%2C+Critical+Care%2C+and+Sleep+Medicine&volume=2&issue=sup1&spage=53&epage=59&aulast=Thavagnanam&aufirst=Surendran&auinit=S.&aufull=Thavagnanam+S.&coden=&isbn=&pages=53-59&date=2018&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 70
TITLE
  Risk Analysis Based on the Timing of Tracheostomy Procedures in Patients 
with Spinal Cord Injury Requiring Cervical Spine Surgery
AUTHOR NAMES
  Galeiras R.; Mourelo M.; Bouza M.T.; Seoane M.T.; Ferreiro M.E.; Montoto A.; Salvador S.; Seoane L.; Freire D.
AUTHOR ADDRESSES
  (Galeiras R.; Mourelo M., monica.mourelo.farina@sergas.es; Bouza M.T.; 
Seoane L.; Freire D.) Critical Care Unit, Complexo Hospitalario 
Universitario de A Coruña, Sergas, Instituto de Investigación, Biomédica de 
A Coruña, Universidade da Coruña, A Coruña, Spain.
(Seoane M.T.) Clinical Epidemiology and Biostatistics Unit, Complexo 
Hospitalario Universitario de A Coruña, Sergas, Instituto de Investigación, 
Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain.
(Ferreiro M.E.; Montoto A.; Salvador S.) Spinal Cord Injury Unit, Complexo 
Hospitalario Universitario de A Coruña, Sergas, Instituto de Investigación, 
Biomédica de A Coruña, Universidade da Coruña, A Coruña, Spain.
CORRESPONDENCE ADDRESS
  M. Mourelo, Critical Care Unit, Complexo Hospitalario Universitario de A 
Coruña, Sergas, Instituto de Investigación, Biomédica de A Coruña, 
Universidade da Coruña, A Coruña, Spain. Email: 
monica.mourelo.farina@sergas.es
AiP/IP ENTRY DATE
  2018-06-13
FULL RECORD ENTRY DATE
  2018-07-30
SOURCE
  World Neurosurgery (2018) 116 (e655-e661). Date of Publication: 1 Aug 2018
VOLUME
  116
FIRST PAGE
  e655
LAST PAGE
  e661
DATE OF PUBLICATION
  1 Aug 2018
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Objective: To determine the optimal moment to perform tracheostomy in a 
patient requiring anterior cervical fixation. Methods: A retrospective 
observational study conducted over an 18-year period included 56 patients 
who had been admitted to the intensive care unit with acute spinal cord 
injury and underwent tracheostomy and surgical fixation. The sample was 
divided into 2 groups: at-risk group (31 patients who had undergone 
tracheostomy before cervical surgery or <4 days after surgery) and 
not-at-risk group (25 patients who had undergone tracheostomy >4 days after 
fixation surgery). Descriptive and comparative studies were carried out. 
Overall trend of the collected data was analyzed using cubic splines 
(graphic methods). Results: The only infectious complications diagnosed as 
related to the surgical procedure were infection of the surgical wound in 2 
patients in the not-at-risk group (12%) and deep tissue infection in 1 
patient in the at-risk group (3.2%). During the study period, we identified 
a tendency toward performance of early tracheostomies. Conclusions: Our 
results suggest that the presence of a tracheostomy stoma before or 
immediately after surgery is associated with a low risk of infection of the 
cervical surgical wound in instrumented spinal fusion.
EMTREE DRUG INDEX TERMS
  vancomycin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spine fusion; cervical spinal cord injury (etiology, surgery); spine stabilization; time factor; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  accidental injury; adult; American Spinal Injury Association impairment scale; antibiotic prophylaxis; APACHE; article; assisted ventilation; Charlson Comorbidity Index; corticosteroid therapy; crush trauma; deep tissue infection (drug therapy, prevention); falling; female; Glasgow coma scale; granuloma; human; injury scale; length of stay; major clinical study; male; medical record review; middle aged; observational study; postoperative hemorrhage; respiratory failure (therapy); retrospective study; risk assessment; Sequential Organ Failure Assessment Score; stenosis; surgical infection (drug therapy, prevention); 
CAS REGISTRY NUMBERS
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180408149
MEDLINE PMID
  29787876 (http://www.ncbi.nlm.nih.gov/pubmed/29787876)
PUI
  L2000828614
DOI
  10.1016/j.wneu.2018.05.065
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2018.05.065
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2018.05.065&atitle=Risk+Analysis+Based+on+the+Timing+of+Tracheostomy+Procedures+in+Patients+with+Spinal+Cord+Injury+Requiring+Cervical+Spine+Surgery&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=116&issue=&spage=e655&epage=e661&aulast=Galeiras&aufirst=Rita&auinit=R.&aufull=Galeiras+R.&coden=&isbn=&pages=e655-e661&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 71
TITLE
  Predictive values of magnetic resonance imaging features for tracheostomy in 
traumatic cervical spinal cord injury
AUTHOR NAMES
  Jeong T.S.; Lee S.G.; Kim W.K.; Ahn Y.; Son S.
AUTHOR ADDRESSES
  (Jeong T.S.; Lee S.G.; Kim W.K.; Ahn Y.; Son S.) Dept of Neurosurgery, 
Incheon, South Korea.
CORRESPONDENCE ADDRESS
  T.S. Jeong, Dept of Neurosurgery, Incheon, South Korea.
FULL RECORD ENTRY DATE
  2018-09-28
SOURCE
  European Spine Journal (2018) 27 Supplement 5 (S663-S664). Date of 
Publication: 1 Aug 2018
VOLUME
  27
FIRST PAGE
  S663
LAST PAGE
  S664
DATE OF PUBLICATION
  1 Aug 2018
CONFERENCE NAME
  Annual Congress of EUROSPINE 2018
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2018-09-19 to 2018-09-21
ISSN
  1432-0932
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background: Traumatic cervical spinal cord injury (SCI) may causerespiratory 
complication that may lead to the need for mechanicalventilation. Magnetic 
resonance (MR) imaging plays a crucial role indetecting and evaluating 
spinal trauma.Purpose of the study: To evaluate the MR imaging features that 
havea statistically significant association with the need for a 
tracheostomyin patients with cervical spinal cord injury during the acute 
stage ofinjury.Materials and methods: This study retrospectively reviewed 
theclinical data of 130 patients with cervical SCI. We analyzed thefactors 
believed to increase the risk of requiring a tracheostomy,including the 
severity of SCI, the level of injury as determined byradiological 
assessment, three quantitative MR imaging parameters,and eleven qualitative 
MR imaging parameters.Results: Significant differences between the 
non-tracheostomy andtracheostomy groups were determined by the following 
five factors onmultivariate analysis: complete SCI (p = 0.007), the 
radiologicallevel of C5 and above (p = 0.038), maximum canal compromise(MCC) 
(p = 0.010), lesion length (p = 0.022), and osteophyte formation (p = 
0.015). For the MCC, the cut-off value was 46%, and therisk of requiring a 
tracheostomy was three times higher at an intervalbetween 50-60% and ten 
times higher between 60-70%. For lesionlength, the cut-off value was 20 mm, 
and the risk of requiring atracheostomy was two times higher at an interval 
between 20-30 mmand fourteen times higher between 40-50 mm.Conclusion: The 
ASIA grade A, a radiological injury level of C5 andabove, an MCC C 50%, a 
lesion length C 20 mm, and osteophyteformation at the level of injury were 
considered to be predictivevalues for requiring tracheostomy intervention in 
patients with cervical SCI (Table 1).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; nuclear magnetic resonance imaging; predictive value; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; conference abstract; controlled study; female; human; major clinical study; male; osteophyte; quantitative analysis; retrospective study; risk assessment; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624030736
DOI
  10.1007/s00586-018-5692-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-018-5692-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-018-5692-z&atitle=Predictive+values+of+magnetic+resonance+imaging+features+for+tracheostomy+in+traumatic+cervical+spinal+cord+injury&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=27&issue=&spage=S663&epage=S664&aulast=Jeong&aufirst=Tae+Seok&auinit=T.S.&aufull=Jeong+T.S.&coden=&isbn=&pages=S663-S664&date=2018&auinit1=T&auinitm=S
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 72
TITLE
  Perioperative management of anterior cervical spine fixation in a patient 
with hereditary angioedema: A case report
AUTHOR NAMES
  Matsuo M.; Shakunaga K.; Sakamoto N.; Yamazaki M.
AUTHOR ADDRESSES
  (Matsuo M.; Sakamoto N.; Yamazaki M.) Department of Anesthesiology, 
University of Toyama, Toyama, Japan.
(Shakunaga K.) Surgical Operation, Toyama University Hospital, Toyama, 
Japan.
AiP/IP ENTRY DATE
  2018-11-27
FULL RECORD ENTRY DATE
  2018-12-04
SOURCE
  Japanese Journal of Anesthesiology (2018) 67:8 (832-835). Date of 
Publication: 1 Aug 2018
VOLUME
  67
ISSUE
  8
FIRST PAGE
  832
LAST PAGE
  835
DATE OF PUBLICATION
  1 Aug 2018
ISSN
  0021-4892
BOOK PUBLISHER
  Kokuseido Publishing Co. Ltd, tkoike@jptco.co.jp
ABSTRACT
  Hereditary angioedema (HAE) is a rare autosomal dominant disorder 
characterized by recurrent episodes of cutaneous or submucosal angioedema 
The condition usually accompanies a deficiency in the Cl esterase inhibitor 
(Cl-INH) that leads to the overproduction of bradykinin, causing an abrupt 
increase in vascular permeability. In the present case, a 44-year-old woman 
with a history of HAE was scheduled to undergo cervical anterior fusion 
surgery. We planned treatment with human Cl-inactivator concentrate 
(Berinert P) prior to surgery and examined her pharynx and larynx by using 
video laryngoscopy (McGRATH®MAC) before intubation but without abnormal 
findings. The operation was performed under total intravenous anesthesia, 
and no significant issue was observed during surgery. The patient was kept 
intubated postoperatively because of potential laryngeal edema attack and 
postoperative hemorrhage. On postoperative day 1, Berinert P and 
dexamethasone were additionally administrated. Then, we extubated the 
trachea safely after significant upper airway edema had been excluded by 
using flexible laryngoscopy. Careful observation and sufficient preparation 
for reintubation or urgent tracheotomy are needed for patients with HAE 
after general anesthesia We demonstrated that HAE could be managed without 
life-threatening airway compromise by employing adequate pharmacological 
interventions and sensible determination of the timing of extubatioa.
EMTREE DRUG INDEX TERMS
  berinert p; complement component C1s inhibitor (drug therapy); dexamethasone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  angioneurotic edema (complication, drug therapy); anterior spine fusion; cervical anterior fusion; perioperative period; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; clinical article; extubation; female; human; intravenous anesthesia; intubation; laryngoscopy; larynx edema (complication); postoperative hemorrhage (complication); postoperative period; videolaryngoscopy; 
DRUG TRADE NAMES
  berinert p
CAS REGISTRY NUMBERS
  complement component C1s inhibitor (80295-37-0, 80295-38-1)
  dexamethasone (50-02-2)
EMBASE CLASSIFICATIONS
  Immunology, Serology and Transplantation (26)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  20180826761
PUI
  L625102028
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00214892&id=doi:&atitle=Perioperative+management+of+anterior+cervical+spine+fixation+in+a+patient+with+hereditary+angioedema%3A+A+case+report&stitle=Jpn.+J.+Anesthesiol.&title=Japanese+Journal+of+Anesthesiology&volume=67&issue=8&spage=832&epage=835&aulast=Matsuo&aufirst=Mitsuhiro&auinit=M.&aufull=Matsuo+M.&coden=MASUA&isbn=&pages=832-835&date=2018&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 73
TITLE
  German National Guideline for Treating Chronic Respiratory Failure with 
Invasive and Non-Invasive Ventilation - Revised Edition 2017: Part 2
AUTHOR NAMES
  Windisch W.; Geiseler J.; Simon K.; Walterspacher S.; Dreher M.; Windisch W.; Dreher M.; Geiseler J.; Siemon K.; Brambring J.; Dellweg D.; Grolle B.; Hirschfeld S.; Köhnlein T.; Mellies U.; Rosseau S.; Schönhofer B.; Schucher B.; Schütz A.; Sitter H.; Stieglitz S.; Storre J.; Winterholler M.; Young P.; Walterspacher S.
AUTHOR ADDRESSES
  (Windisch W.) Department of Pneumology, Cologne Merheim Hospital, Kliniken 
der Stadt Köln GGmbH, Cologne, Germany.
(Windisch W.; Walterspacher S.) Faculty of Health/School of Medicine, 
Witten/Herdecke University, Witten, Germany.
(Geiseler J.) Medical Clinic IV, Pneumology, Sleep Medicine and Mechanical 
Ventilation, Paracelsus-Klinik Marl, Marl, Germany.
(Simon K.) Fachkrankenhaus Kloster Grafschaft GmbH, Center for Pneumology 
and Allergology, Schmallenberg, Germany.
(Walterspacher S.) Medical Clinic II, Department of Pneumology, Cardiology 
and Intensive Care Medicine, Klinikum Konstanz, Konstanz, Germany.
(Dreher M.) Division of Pneumology, University Hospital RWTH Aachen, Aachen, 
Germany.
(Windisch W.; Dreher M.; Geiseler J.; Siemon K.; Brambring J.; Dellweg D.; 
Grolle B.; Hirschfeld S.; Köhnlein T.; Mellies U.; Rosseau S.; Schönhofer 
B.; Schucher B.; Schütz A.; Sitter H.; Stieglitz S.; Storre J.; Winterholler 
M.; Young P.; Walterspacher S.)
AiP/IP ENTRY DATE
  2018-07-10
FULL RECORD ENTRY DATE
  2018-12-28
SOURCE
  Respiration (2018) 96:2 (171-203). Date of Publication: 1 Aug 2018
VOLUME
  96
ISSUE
  2
FIRST PAGE
  171
LAST PAGE
  203
DATE OF PUBLICATION
  1 Aug 2018
ISSN
  1423-0356 (electronic)
  0025-7931
BOOK PUBLISHER
  S. Karger AG
ABSTRACT
  Today, invasive and non-invasive home mechanical ventilation have become a 
well-established treatment option. Consequently, in 2010, the German 
Respiratory Society (DGP) has leadingly published the guidelines on 
"Non-Invasive and Invasive Mechanical Ventilation for Treatment of Chronic 
Respiratory Failure." However, continuing technical evolutions, new 
scientific insights, and health care developments require an extensive 
revision of the guidelines. For this reason, the updated guidelines are now 
published. Thereby, the existing chapters, namely technical issues, 
organizational structures in Germany, qualification criteria, 
disease-specific recommendations including special features in pediatrics as 
well as ethical aspects and palliative care, have been updated according to 
the current literature and the health care developments in Germany. New 
chapters added to the guidelines include the topics of home mechanical 
ventilation in paraplegic patients and in those with failure of prolonged 
weaning. In the current guidelines, different societies as well as 
professional and expert associations have been involved when compared to the 
2010 guidelines. Importantly, disease-specific aspects are now covered by 
the German Interdisciplinary Society of Home Mechanical Ventilation (DIGAB). 
In addition, societies and associations directly involved in the care of 
patients receiving home mechanical ventilation have been included in the 
current process. Importantly, associations responsible for decisions on 
costs in the health care system and patient organizations have now been 
involved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; chronic respiratory failure; patient care; practice guideline; 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; bronchiectasis; central hypoventilation syndrome; chronic obstructive lung disease; comorbidity; coughing; cystic fibrosis; decision making; diaphragm stimulation; documentation; Epworth sleepiness scale; forced vital capacity; Germany; health care cost; health care organization; health care system; human; hypercapnia; hypoventilation; lung fibrosis; multichannel recorder; muscle weakness; nerve stimulation; nursing care; obesity hypoventilation syndrome; oxygen therapy; palliative therapy; paraplegia; phrenic nerve stimulation; polysomnography; positive end expiratory pressure; priority journal; quality of life; respiratory acidosis; review; sleep disordered breathing; spinal cord transsection; spirometry; terminal care; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29945156 (http://www.ncbi.nlm.nih.gov/pubmed/29945156)
PUI
  L622904630
DOI
  10.1159/000488667
FULL TEXT LINK
  http://dx.doi.org/10.1159/000488667
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14230356&id=doi:10.1159%2F000488667&atitle=German+National+Guideline+for+Treating+Chronic+Respiratory+Failure+with+Invasive+and+Non-Invasive+Ventilation+-+Revised+Edition+2017%3A+Part+2&stitle=Respiration&title=Respiration&volume=96&issue=2&spage=171&epage=203&aulast=Windisch&aufirst=Wolfram&auinit=W.&aufull=Windisch+W.&coden=RESPB&isbn=&pages=171-203&date=2018&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 74
TITLE
  Seated-Baduanjin as an adjuvant rehabilitation treatment for dysfunctional 
ventilatory weaning response: A case report
AUTHOR NAMES
  Chen M.; Zeng R.-X.; Liang X.; Hu X.; Kong L.; Wang J.; Guo L.; Zhang M.-Z.; Zhang X.
AUTHOR ADDRESSES
  (Chen M.; Zeng R.-X.; Liang X.; Hu X.; Kong L.; Wang J.; Guo L.; Zhang 
M.-Z.; Zhang X., zhxiaoxuan2003@163.com) Division of Chest Pain Center, 
Guangdong Provincial Hospital of Chinese Medicine, 2nd Clinical College of 
Guangzhou University of Chinese Medicine, No 111 Dade Road, Guangzhou, 
China.
CORRESPONDENCE ADDRESS
  X. Zhang, Division of Chest Pain Center, Guangdong Provincial Hospital of 
Chinese Medicine, 2nd Clinical College of Guangzhou University of Chinese 
Medicine, No 111 Dade Road, Guangzhou, China. Email: zhxiaoxuan2003@163.com
AiP/IP ENTRY DATE
  2019-05-14
FULL RECORD ENTRY DATE
  2019-05-16
SOURCE
  Medicine (United States) (2018) 97:34 Article Number: e11854. Date of 
Publication: 1 Aug 2018
VOLUME
  97
ISSUE
  34
DATE OF PUBLICATION
  1 Aug 2018
ISSN
  1536-5964 (electronic)
  0025-7974
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Rationale: Seated-Baduanjin as adjuvant rehabilitation treatment in a 
patient with Dysfunctional ventilatory weaning response (DVWR) is extremely 
rare, and we report a case of a patient’s rehabilitation exercise who 
suffered from DVWR. Patient concerns: A 62-year-old patient was admitted for 
dyspnea for more than a month after surgery. Diagnoses: On arrival, the 
patient was conscious but anxious, and he had difficulty breathing. When 
attempting to disconnect the ventilator, the patient’s autonomous 
respiration > 25 times /min, and the heart rate > 120 times /min. He had to 
rely on the ventilator to survive. According to the characteristics of the 
patient, we considered the patient with DVWR. Interventions: We provided the 
same essential treatment as the last hospital and performed the 
Seated-Baduanjin for the patient which was a new form of bed exercise, 2 
times a day, 30 minutes each time. Outcomes: The patient showed a gradual 
improvement in breathing and muscle strength. Lessons: In this case report, 
the Seated-Baduanjin showed a remarkable therapeutic effect on a patient and 
might be an adjuvant treatment for DVWR.
EMTREE DRUG INDEX TERMS
  ceftazidime; enoxaparin; voriconazole; warfarin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adjuvant therapy; dysfunctional ventilatory weaning response (rehabilitation); lung disease (rehabilitation); pulmonary rehabilitation; seated baduanjin; 
EMTREE MEDICAL INDEX TERMS
  adult; anticoagulation; aortic arch surgery; aortic dissection; article; artificial ventilation; ascending aorta surgery; body temperature; case report; clinical article; critically ill patient; dyspnea; fatigue; general anesthesia; heart rate; hospital admission; hospital discharge; hospitalization; human; infection control; leg muscle; lower extremity deep vein thrombosis; lung auscultation; lung infection; male; middle aged; muscle strength; paraplegia; physical examination; priority journal; respiratory failure; spinal cord injury; sputum culture; tracheotomy; 
CAS REGISTRY NUMBERS
  ceftazidime (72558-82-8)
  enoxaparin (679809-58-6)
  voriconazole (137234-62-9)
  warfarin (129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30142776 (http://www.ncbi.nlm.nih.gov/pubmed/30142776)
PUI
  L627463169
DOI
  10.1097/MD.0000000000011854
FULL TEXT LINK
  http://dx.doi.org/10.1097/MD.0000000000011854
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15365964&id=doi:10.1097%2FMD.0000000000011854&atitle=Seated-Baduanjin+as+an+adjuvant+rehabilitation+treatment+for+dysfunctional+ventilatory+weaning+response%3A+A+case+report&stitle=Medicine&title=Medicine+%28United+States%29&volume=97&issue=34&spage=&epage=&aulast=Chen&aufirst=Minggui&auinit=M.&aufull=Chen+M.&coden=MEDIA&isbn=&pages=-&date=2018&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 75
TITLE
  Is the face an air bag for the brain and torso? - The potential protective 
effects of severe midface fractures
AUTHOR NAMES
  Woriax H.E.; Hamill M.E.; Gilbert C.M.; Reed C.M.; Faulks E.R.; Love K.M.; Lollar D.I.; Nussbaum M.S.; Collier B.R.
AUTHOR ADDRESSES
  (Woriax H.E.; Hamill M.E., hamillm@mac.com; Gilbert C.M.; Reed C.M.; Faulks 
E.R.; Love K.M.; Lollar D.I.; Nussbaum M.S.; Collier B.R.) Department of 
Surgery, Virginia Tech., Carilion School of Medicine, 1906 Belleview Avenue 
SE, Roanoke, United States.
(Reed C.M.) Department of Surgery, Duke University, Durham, United States.
CORRESPONDENCE ADDRESS
  M.E. Hamill, Department of Surgery, Virginia Tech., Carilion School of 
Medicine, 1906 Belleview Avenue SE, Roanoke, United States. Email: 
hamillm@mac.com
AiP/IP ENTRY DATE
  2018-09-17
FULL RECORD ENTRY DATE
  2018-10-24
SOURCE
  American Surgeon (2018) 84:8 (1299-1302). Date of Publication: 1 Aug 2018
VOLUME
  84
ISSUE
  8
FIRST PAGE
  1299
LAST PAGE
  1302
DATE OF PUBLICATION
  1 Aug 2018
ISSN
  0003-1348
BOOK PUBLISHER
  Southeastern Surgical Congress, SESC@sesc.org
ABSTRACT
  We investigated the patterns of injury associated with major midface trauma. 
Our hypothesis is that midface injuries are associated with a decrease in 
certain traumatic brain injuries as well as major torso injuries. The 
registry of our Level I trauma center was queried for all adult patients 
treated over 25 years from 1989 to 2013. Patients with midface fractures 
were identified based on the ICD-9 code. Associated injuries were defined 
based both on individual ICD-9 codes as well as the Barell Injury Matrix. 
Injury etiology was defined based on e-codes. Univariate analysis was 
performed using chi-squared test, Fisher's exact test, and Wilcoxon test. A 
total of 29,152 patients were identified. Excluding pediatric patients, 
those with exclusively penetrating trauma, and patients with incomplete 
data, 20,971 patients were included for subsequent analysis. Midface 
fractures were identified in 752 patients. Patients with Le Fort fractures 
were more likely to be male, have a higher Injury Severity Score, a lower 
arrival Glasgow Coma Scale, and more likely to require intensive care unit 
admission and mechanical ventilation, with a longer hospital length of stay. 
Patients with midface fractures had significantly fewer subdural hematomas, 
subarachnoid hemorrhages, spine fractures, and were less likely to have 
associated abdominal and pelvic injuries. Patients with midface fractures 
were more likely to require facial reconstruction procedures and craniotomy. 
Patients presenting with midface fractures after blunt trauma have a 
distinctly different pattern of injuries. One potential mechanism for this 
is a deceleration effect, where midface impact and resulting fractures 
dissipate some of the energy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airbag; face injury (prevention, surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal injury (prevention); adult; article; artificial ventilation; assault; Barell Injury Matrix; blood transfusion; blunt trauma; craniectomy; craniotomy; disease assessment; disease association; disease registry; face fracture (prevention, surgery); face surgery; falling; female; Glasgow coma scale; hospital admission; human; ICD-9; injury scale; injury severity; intensive care unit; laparotomy; length of stay; liver resection; major clinical study; male; maxilla fracture (prevention, surgery); middle aged; open reduction (procedure); osteosynthesis; pelvis injury (prevention); protective equipment; sex difference; spine fracture (prevention); spine fusion; splenectomy; subarachnoid hemorrhage (prevention); subdural hematoma (prevention); thoracotomy; thorax injury (prevention); tracheostomy; traffic accident; traumatic brain injury (prevention); ventriculostomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180627973
MEDLINE PMID
  30185304 (http://www.ncbi.nlm.nih.gov/pubmed/30185304)
PUI
  L623844433
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00031348&id=doi:&atitle=Is+the+face+an+air+bag+for+the+brain+and+torso%3F+-+The+potential+protective+effects+of+severe+midface+fractures&stitle=Am.+Surg.&title=American+Surgeon&volume=84&issue=8&spage=1299&epage=1302&aulast=Woriax&aufirst=Hannah+E.&auinit=H.E.&aufull=Woriax+H.E.&coden=AMSUA&isbn=&pages=1299-1302&date=2018&auinit1=H&auinitm=E
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 76
TITLE
  Surgical decompression for recurrent cord compression in cancer: a case 
series and review of the literature
AUTHOR NAMES
  Rajah G.; Rapp A.; Discolo E.; Eltahawy H.
AUTHOR ADDRESSES
  (Rajah G.; Discolo E.; Eltahawy H., heltahawy@gmail.com) Department of 
Neurosurgery, Wayne State University, Detroit, United States.
(Eltahawy H., heltahawy@gmail.com) Department of Neurosurgery, Ain Shams 
University, Cairo, Egypt.
(Rapp A.) Department of Surgery, St. Joseph Mercy Oakland, Pontiac, United 
States.
(Eltahawy H., heltahawy@gmail.com) Department of Neurosurgery, St. Mary 
Mercy Livonia, Livonia, United States.
CORRESPONDENCE ADDRESS
  H. Eltahawy, Department of Neurosurgery, Wayne State University, Detroit, 
United States. Email: heltahawy@gmail.com
AiP/IP ENTRY DATE
  2018-04-04
FULL RECORD ENTRY DATE
  2018-11-06
SOURCE
  Neurological Research (2018) 40:7 (551-556). Date of Publication: 3 Jul 2018
VOLUME
  40
ISSUE
  7
FIRST PAGE
  551
LAST PAGE
  556
DATE OF PUBLICATION
  3 Jul 2018
ISSN
  1743-1328 (electronic)
  0161-6412
BOOK PUBLISHER
  Taylor and Francis Ltd., michael.wagreich@univie.ac.at
ABSTRACT
  Spine metastases affect a significant number of cancer patients each year, 
with the spine being the third most common location for cancer spread. As 
patients live longer with improved treatments, the opportunity for 
recurrence at previously treated sites increases. Here, we describe seven 
patients with recurrent, compressive, metastatic spine tumors at previously 
surgically treated sites that required additional surgical intervention with 
manipulation of at least one rod. Five of the patients had recurrence 
including adjacent levels while two had recurrence solely at the previously 
decompressed level. The patients remained ambulatory for an average of 
31.2 months after the initial surgery. We also discuss the role of adjuvant 
treatment in these patients and review the literature.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  decompression surgery; spinal cord compression; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; breast cancer; clinical article; colon adenocarcinoma; deep vein thrombosis; follow up; gastrostomy; human; laminectomy; middle aged; mobilization; pancytopenia; pleura effusion; renal cell carcinoma; sarcoma; scar; sepsis; spine metastasis; stomach tube; tracheostomy; tumor recurrence; tumor volume; 
EMBASE CLASSIFICATIONS
  Arthritis and Rheumatism (31)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180233779
MEDLINE PMID
  29600884 (http://www.ncbi.nlm.nih.gov/pubmed/29600884)
PUI
  L621493564
DOI
  10.1080/01616412.2018.1453178
FULL TEXT LINK
  http://dx.doi.org/10.1080/01616412.2018.1453178
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17431328&id=doi:10.1080%2F01616412.2018.1453178&atitle=Surgical+decompression+for+recurrent+cord+compression+in+cancer%3A+a+case+series+and+review+of+the+literature&stitle=Neurol.+Res.&title=Neurological+Research&volume=40&issue=7&spage=551&epage=556&aulast=Rajah&aufirst=Gary&auinit=G.&aufull=Rajah+G.&coden=NRESD&isbn=&pages=551-556&date=2018&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 77
TITLE
  A selective placement strategy for surgical feeding tubes benefits trauma 
patients
AUTHOR NAMES
  Marcotte J.; Hazelton J.P.; Arya C.; Dalton M.; Batool A.; Gaughan J.; Nguyen L.; Porter J.; Fox N.
AUTHOR ADDRESSES
  (Marcotte J., Marcotte-joseph@cooperhealth.edu; Hazelton J.P.; Gaughan J.; 
Porter J.; Fox N.) Department of Surgery, Cooper University Hospital, 1 
Cooper Plaza, Camden, United States.
(Arya C.) Rowan University, Glassboro, United States.
(Dalton M.) Department of Surgery, St. Barnabas Medical Center, Livingston, 
United States.
(Batool A.) Department of Surgery, Lancaster General Hospital, Lancaster, 
United States.
(Nguyen L.) Jefferson Medical School, Philadelphia, United States.
CORRESPONDENCE ADDRESS
  J. Marcotte, Department of Surgery, Cooper University Hospital, 1 Cooper 
Plaza, Camden, United States. Email: Marcotte-joseph@cooperhealth.edu
AiP/IP ENTRY DATE
  2019-02-28
FULL RECORD ENTRY DATE
  2019-03-06
SOURCE
  Journal of Trauma and Acute Care Surgery (2018) 85:1 (135-139). Date of 
Publication: 1 Jul 2018
VOLUME
  85
ISSUE
  1
FIRST PAGE
  135
LAST PAGE
  139
DATE OF PUBLICATION
  1 Jul 2018
ISSN
  2163-0763 (electronic)
  2163-0755
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  BACKGROUND The indications for surgical feeding tube (SFT) placement in 
trauma patients are poorly defined. Patient selection is critical as 
complications from SFTs have been reported in up to 70% of patients. A 
previous analysis by our group determined that 25% of the SFTs we placed 
were unnecessary and that older patients, patients with head and spinal cord 
injuries, and patients who needed a tracheostomy were more likely to require 
long-term SFTs. Following this study, we modified our institutional 
guidelines for SFT placement. We hypothesized that a more selective 
placement strategy would result in fewer unnecessary SFTs. METHODS A 
retrospective review of all adult patients from 2012 to 2016 with an 
intensive care unit length of stay longer than 4 days and an SFT placed 
during admission was conducted. This group was compared to data collected 
prior to our change in practice (2007-2010). Data from 2011 were excluded as 
a washout period. "Necessary" SFT use was defined per established guidelines 
as either daily use of the SFT through discharge or for 28 days or longer 
and "unnecessary" SFT use as all others. RESULTS Two hundred fifty-seven 
SFTs were placed from 2007 to 2010 and 244 from 2012 to 2016. Following 
implementation of our selective SFT placement strategy, unnecessary SFT 
placement decreased from 25% in 2007 to 2010 to 8% in 2012 to 2016 (p < 
0.0001). Significant predictors of necessary SFT placement by univariate 
regression were as follows: increasing age (odds ratio [OR] 1.03/year; 95% 
confidence interval [CI], 1.01-1.04), head injury (OR, 2.80; 95% CI, 
1.71-4.60), cervical spinal cord injury (OR, 4.42; 95% CI, 1.34-14.50), and 
need for tracheostomy (OR, 1.41; 95% CI, 2.21-7.67). The overall 
complication rate was 11% (9% in the selective group vs. 13% in the 
preselective group, p = 0.2574) and was highest following open SFT placement 
(22%). CONCLUSION A selective placement strategy for SFTs in our trauma 
population resulted in fewer unnecessary SFTs and a trend toward fewer 
complications. Surgical feeding tubes should be placed through a 
percutaneous approach whenever possible. LEVEL OF EVIDENCE Therapeutic 
study, level IV.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; feeding tube; head injury; 
EMTREE MEDICAL INDEX TERMS
  adult; conference paper; controlled study; female; human; intensive care unit; length of stay; major clinical study; male; practice guideline; priority journal; retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Gastroenterology (48)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29521796 (http://www.ncbi.nlm.nih.gov/pubmed/29521796)
PUI
  L626499013
DOI
  10.1097/TA.0000000000001867
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0000000000001867
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0000000000001867&atitle=A+selective+placement+strategy+for+surgical+feeding+tubes+benefits+trauma+patients&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=85&issue=1&spage=135&epage=139&aulast=Marcotte&aufirst=Joseph&auinit=J.&aufull=Marcotte+J.&coden=&isbn=&pages=135-139&date=2018&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 78
TITLE
  Percutaneous Dilatational Tracheostomy in Ankylosing Spondylitis (Bechterew 
Disease) Is Feasible and Not Associated With Higher Complication Rates
AUTHOR NAMES
  Hamsen U.; Kamp O.; Kaczmarek C.; Aach M.; Waydhas C.; Schildhauer T.A.; Jansen O.
AUTHOR ADDRESSES
  (Hamsen U., uwe.hamsen@bergmannsheil.de; Kamp O.; Kaczmarek C.; Waydhas C.; 
Schildhauer T.A.; Jansen O.) Department of General and Trauma Surgery, BG 
University Hospital Bergmannsheil, Bochum, Germany.
(Aach M.) Department of Spinal Cord Injuries, BG University Hospital 
Bergmannsheil, Bochum, Germany.
(Waydhas C.) Medical Faculty University Duisburg-Essen, Germany.
CORRESPONDENCE ADDRESS
  U. Hamsen, BG University Hospital Bergmannsheil, Buerkle de la Camp Platz 1, 
Bochum, Germany. Email: uwe.hamsen@bergmannsheil.de
AiP/IP ENTRY DATE
  2018-06-13
FULL RECORD ENTRY DATE
  2018-12-27
SOURCE
  Journal of Intensive Care Medicine (2018) 33:7 (420-423). Date of 
Publication: 1 Jul 2018
VOLUME
  33
ISSUE
  7
FIRST PAGE
  420
LAST PAGE
  423
DATE OF PUBLICATION
  1 Jul 2018
ISSN
  1525-1489 (electronic)
  0885-0666
BOOK PUBLISHER
  SAGE Publications Inc., claims@sagepub.com
ABSTRACT
  Background: Ankylosing spondylitis (AS) is a common disease with an 
incidence of approximately 0.5% in Europe, causing severe limitations of 
axial spine mobility and cervical kyphosis. Deformities of the cervical 
spine and the temporomandibular joints could increase the risk of 
complications while performing an intubation or tracheostomy. The 
percutaneous dilatational tracheostomy (PDT) is a standard procedure in 
intensive care medicine. However, the combination of cervical kyphosis and 
osteoporosis makes patient positioning challenging. Therefore, one could 
conclude that patients with AS are not candidates for PDT, but neither 
studies nor case reports yet reported about feasibility of this procedure in 
AS. Methods: Retrospective analysis at a level 1 trauma center of patient 
records from 2002 to 2016, assessing all patients with AS and PDT. Results: 
A total of 31 patients with AS have been subjected to PDT. All PDTs were 
performed using the modified Ciaglia single-step dilatational technique. 
Neither cardiopulmonary nor surgical complications occurred during the 
procedure. One patient received a change of the existing airway prior to the 
procedure; a small nasal tube was changed for a laryngeal mask. Conclusion: 
Although head positioning may be challenging, PDT should be taken into 
consideration for patients with AS. In the hands of an experienced doctor, 
it is safe and feasible.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  aged; article; ciaglia single step dilatational technique; echography; female; human; intensive care unit; intubation; kyphosis; laryngeal mask; major clinical study; male; osteoporosis; postoperative complication; priority journal; retrospective study; spinal cord injury; spine fracture; surgical technique; tracheostomy kit; 
DEVICE TRADE NAMES
  Ciaglia Blue Rhino  , United StatesCook Medical

DEVICE MANUFACTURERS
   (United States)Cook Medical
EMBASE CLASSIFICATIONS
  Arthritis and Rheumatism (31)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  27852959 (http://www.ncbi.nlm.nih.gov/pubmed/27852959)
PUI
  L622502343
DOI
  10.1177/0885066616677959
FULL TEXT LINK
  http://dx.doi.org/10.1177/0885066616677959
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15251489&id=doi:10.1177%2F0885066616677959&atitle=Percutaneous+Dilatational+Tracheostomy+in+Ankylosing+Spondylitis+%28Bechterew+Disease%29+Is+Feasible+and+Not+Associated+With+Higher+Complication+Rates&stitle=J.+Intensive+Care+Med.&title=Journal+of+Intensive+Care+Medicine&volume=33&issue=7&spage=420&epage=423&aulast=Hamsen&aufirst=Uwe&auinit=U.&aufull=Hamsen+U.&coden=JICME&isbn=&pages=420-423&date=2018&auinit1=U&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 79
TITLE
  Complications following lengthening of spinal growing implants: Is 
postoperative admission necessary?
AUTHOR NAMES
  Shaw K.A.; Fletcher N.D.; Devito D.P.; Murphy J.S.
AUTHOR ADDRESSES
  (Shaw K.A., kenneth.a.shaw34.mil@mail.mil) Department of Orthopaedic 
Surgery, Dwight D. Eisenhower Army Medical Center, Fort Gordon, United 
States.
(Fletcher N.D.) Department of Orthopaedics, Emory University, Atlanta, 
United States.
(Devito D.P.; Murphy J.S.) Department of Pediatric Orthopaedic Surgery, 
Children's Healthcare of Atlanta, United States.
CORRESPONDENCE ADDRESS
  K.A. Shaw, Department of Orthopaedic Surgery, Dwight D. Eisenhower Army 
Medical Center, Fort Gordon, United States. Email: 
kenneth.a.shaw34.mil@mail.mil
AiP/IP ENTRY DATE
  2018-07-17
FULL RECORD ENTRY DATE
  2018-07-18
SOURCE
  Journal of Neurosurgery: Pediatrics (2018) 22:1 (102-107). Date of 
Publication: 1 Jul 2018
VOLUME
  22
ISSUE
  1
FIRST PAGE
  102
LAST PAGE
  107
DATE OF PUBLICATION
  1 Jul 2018
ISSN
  1933-0715 (electronic)
  1933-0707
BOOK PUBLISHER
  American Association of Neurological Surgeons
ABSTRACT
  OBJECTIVE: The aim of this study was to evaluate the effect of postoperative 
admission status on 30-day perioperative complications in patients with 
growing spinal instrumentation undergoing surgical lengthening. METHODS: 
This retrospective case-control study of records from the 2014-2015 National 
Surgical Quality Improvement Program-Pediatric database was performed to 
identify surgical lengthening procedures of spinal implants in patients with 
growing instrumentation by Current Procedural Terminology code. The 30-day 
postoperative complications were classified according to the Clavien-Dindo 
system. Patients were subdivided according to their postsurgical admission 
status. Admission status, American Society of Anesthesiologists (ASA) 
Physical Status classification, tracheostomy, neuromuscular diagnosis, 
ventilator dependence, and nutritional support were considered as possible 
risk factors in univariate and multivariate logistic regression analyses. 
RESULTS: A total of 796 patients were identified (mean age 9.09 ± 3.44 
years; 54% of patients were female), of whom 73% underwent lengthening on an 
inpatient basis. Patients with a tracheostomy or ventilator dependence were 
more likely to be admitted postoperatively. The overall rate of major 
complications was 3.5% and did not differ based on admission status (2.8% 
inpatient vs 3.8% outpatient, p = 0.517). On univariate analysis, ventilator 
dependence (9.5% vs 2.7%, p = 0.002), need for nutritional support (7.1% vs 
2.5%, p = 0.006), and ASA class > II (4.8% vs 1.3%, p = 0.04) placed 
patients at a higher risk for any postoperative complications. Multivariate 
analysis identified only ventilator dependence as an independent risk factor 
for any perioperative complication. CONCLUSIONS: Postoperative admission 
status did not affect the rate of 30-day perioperative complications, 
readmission, or rate of unplanned operations following lengthening of 
growing spinal instrumentation. Outpatient lengthening appears to be safe; 
however, consideration for postoperative admission should be given for those 
who are ventilator dependent.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  peroperative complication (complication); spine implant (adverse device effect); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; case control study; child; cohort analysis; conference paper; female; hospital readmission; human; implant failure (complication); major clinical study; male; nerve injury; nutritional support; pneumonia; postoperative infection; postoperative period; priority journal; prosthesis complication (complication); reoperation; retrospective study; school child; sepsis; superficial dehiscence; superficial infection; tracheostomy; urinary tract infection; venous thromboembolism; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29701559 (http://www.ncbi.nlm.nih.gov/pubmed/29701559)
PUI
  L622996418
DOI
  10.3171/2018.2.PEDS1827
FULL TEXT LINK
  http://dx.doi.org/10.3171/2018.2.PEDS1827
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19330715&id=doi:10.3171%2F2018.2.PEDS1827&atitle=Complications+following+lengthening+of+spinal+growing+implants%3A+Is+postoperative+admission+necessary%3F&stitle=J.+Neursurg.+Pediatr.&title=Journal+of+Neurosurgery%3A+Pediatrics&volume=22&issue=1&spage=102&epage=107&aulast=Shaw&aufirst=K.+Aaron&auinit=K.A.&aufull=Shaw+K.A.&coden=&isbn=&pages=102-107&date=2018&auinit1=K&auinitm=A
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 80
TITLE
  Bilateral vocal cord palsy after a posterior cervical laminoplasty
AUTHOR NAMES
  Iwai C.; Fushimi K.; Nozawa S.; Shirai Y.; Ogawa H.; Yasura K.; Shimizu K.; Akiyama H.
AUTHOR ADDRESSES
  (Iwai C.; Fushimi K., kfus@gifu-u.ac.jp; Nozawa S.; Ogawa H.; Akiyama H.) 
Department of Orthopaedic Surgery, Gifu University Graduate School of 
Medicine, 1-1 Yanagido, Gifu City, Japan.
(Shirai Y.; Yasura K.; Shimizu K.) Department of Orthopaedic Surgery, Spine 
Center, Gifu Municipal Hospital, Gifu, Japan.
CORRESPONDENCE ADDRESS
  K. Fushimi, Department of Orthopaedic Surgery, Gifu University Graduate 
School of Medicine, 1-1 Yanagido, Gifu City, Japan. Email: kfus@gifu-u.ac.jp
AiP/IP ENTRY DATE
  2018-06-19
FULL RECORD ENTRY DATE
  2018-07-23
SOURCE
  European Spine Journal (2018) 27 Supplement 3 (549-554). Date of 
Publication: 1 Jul 2018
VOLUME
  27
FIRST PAGE
  549
LAST PAGE
  554
DATE OF PUBLICATION
  1 Jul 2018
ISSN
  1432-0932 (electronic)
  0940-6719
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Purpose: To report a patient with bilateral vocal cord palsy following 
cervical laminoplasty, who survived following a tracheotomy and intensive 
respiratory care. Methods: Acute respiratory distress is a fatal 
complication of cervical spinal surgery. The incidence of bilateral vocal 
cord palsy after posterior cervical decompression surgery is extremely rare. 
The authors report a 71-year-old woman who suffered from cervical myelopathy 
due to ossification of the posterior longitudinal ligament. Open-door 
laminoplasty from C2 to C6 and laminectomy of C1 were performed. Following 
surgery, extubation was successfully conducted. Acute-onset dysphagia and 
stridor had occurred 2 h following extubation. A postoperative fiber optic 
laryngoscope revealed bilateral vocal cord palsy. After a tracheotomy and 
intensive respiratory care, she had completely recovered 2 months after 
surgery. Discussion: One potential cause of this pathology was an 
intraoperative hyper-flexed neck position, which likely induced mechanical 
impingement of the larynx, resulting in swelling and edema of the vocal 
cords and recurrent laryngeal nerve paresis. Direct trauma of the vocal 
cords during intubation and extubation could have also induced vocal cord 
paralysis. Conclusions: We reported a case of bilateral vocal cord palsy 
associated with posterior cervical laminoplasty. Airway complications 
following posterior spinal surgery are rare, but they do occur; therefore, 
spine surgeons should be aware of them and take necessary precautions 
against intraoperative neck position, intubation technique, even positioning 
of the intratracheal tube.
EMTREE DRUG INDEX TERMS
  fentanyl (drug therapy, intravenous drug administration); hydrocortisone (drug therapy); propofol; remifentanil; rocuronium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bilateral vocal cord palsy (complication, diagnosis, rehabilitation); laminoplasty; posterior cervical laminoplasty; postoperative complication (complication, diagnosis, rehabilitation); vocal cord paralysis (complication, diagnosis, rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  aged; anesthesia induction; article; artificial ventilation; aspiration pneumonia (prevention); bladder dysfunction; breathing; cannula; case report; cervical myelopathy (diagnosis); cervical spine radiography; clinical article; consciousness; continuous infusion; dexterity test; dysphagia; elective surgery; endotracheal intubation; endotracheal tube cuff; extubation; female; fiberoptic laryngoscope; first cervical vertebra; french open door laminoplasty; head holder; human; hyperreflexia; hypertension; intensive care; intestine function disorder; laminectomy; larynx edema (drug therapy); lower limb; medical history; nasogastric tube; nuclear magnetic resonance imaging; operation duration; operative blood loss; otolaryngologist; oxygen saturation; paralysis; paresthesia; posterior longitudinal ligament; postoperative analgesia; postoperative pain (drug therapy); postoperative period; priority journal; prone position; respiratory care; rigid laryngoscope; sixth cervical vertebra; spastic gait; speech therapy; stridor; swallowing; tendon reflex; tracheostomy; tracheotomy; upper limb; vertebral canal stenosis (diagnosis); videolaryngoscope; vocal cord; voluntary movement; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  hydrocortisone (50-23-7)
  propofol (2078-54-8)
  remifentanil (132539-07-2)
  rocuronium (119302-91-9)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29948324 (http://www.ncbi.nlm.nih.gov/pubmed/29948324)
PUI
  L622557302
DOI
  10.1007/s00586-018-5649-2
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-018-5649-2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-018-5649-2&atitle=Bilateral+vocal+cord+palsy+after+a+posterior+cervical+laminoplasty&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=27&issue=&spage=549&epage=554&aulast=Iwai&aufirst=Chizuo&auinit=C.&aufull=Iwai+C.&coden=ESJOE&isbn=&pages=549-554&date=2018&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 81
TITLE
  The rule is: There are no rules
AUTHOR NAMES
  Tshiombo G.
AUTHOR ADDRESSES
  (Tshiombo G., gianbattistatshiombo@fondazionecariplo.it) Fondazione Cariplo, 
Milan, Italy.
AiP/IP ENTRY DATE
  2018-04-19
FULL RECORD ENTRY DATE
  2018-08-01
SOURCE
  International Journal of Cardiology (2018) 261 (179-180). Date of 
Publication: 15 Jun 2018
VOLUME
  261
FIRST PAGE
  179
LAST PAGE
  180
DATE OF PUBLICATION
  15 Jun 2018
ISSN
  1874-1754 (electronic)
  0167-5273
BOOK PUBLISHER
  Elsevier Ireland Ltd
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); endovascular aneurysm repair; 
EMTREE MEDICAL INDEX TERMS
  aortic aneurysm; blood vessel rupture; cerebrovascular accident; clinical effectiveness; dialysis; disease severity; editorial; human; mortality; open surgery; outcome assessment; priority journal; reoperation; respiratory failure; sensitivity and specificity; spinal cord injury; stent graft; thrombosis; tracheostomy; treatment outcome; treatment response; vocal cord paralysis; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180272826
MEDLINE PMID
  29657041 (http://www.ncbi.nlm.nih.gov/pubmed/29657041)
PUI
  L2000535101
DOI
  10.1016/j.ijcard.2018.02.086
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijcard.2018.02.086
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18741754&id=doi:10.1016%2Fj.ijcard.2018.02.086&atitle=The+rule+is%3A+There+are+no+rules&stitle=Int.+J.+Cardiol.&title=International+Journal+of+Cardiology&volume=261&issue=&spage=179&epage=180&aulast=Tshiombo&aufirst=Gianbattista&auinit=G.&aufull=Tshiombo+G.&coden=IJCDD&isbn=&pages=179-180&date=2018&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 82
TITLE
  Indications and complications of rigid bronchoscopy
AUTHOR NAMES
  Batra H.; Yarmus L.
AUTHOR ADDRESSES
  (Batra H.; Yarmus L., lyarmus@jhmi.edu) Interventional Pulmonology, Division 
of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, 
United States.
CORRESPONDENCE ADDRESS
  L. Yarmus, Johns Hopkins Hospital, Sheikh Zayed Tower, 1800 Orleans St, 
Suite 7-125, Baltimore, United States. Email: lyarmus@jhmi.edu
AiP/IP ENTRY DATE
  2018-06-11
FULL RECORD ENTRY DATE
  2018-06-13
SOURCE
  Expert Review of Respiratory Medicine (2018) 12:6 (509-520). Date of 
Publication: 3 Jun 2018
VOLUME
  12
ISSUE
  6
FIRST PAGE
  509
LAST PAGE
  520
DATE OF PUBLICATION
  3 Jun 2018
ISSN
  1747-6356 (electronic)
  1747-6348
BOOK PUBLISHER
  Taylor and Francis Ltd
ABSTRACT
  Introduction: Rigid bronchoscopy is an invaluable tool for the management of 
airway disorders and an essential skill for an interventional pulmonologist. 
Since its introduction in the late 19th century, it has remained an 
important technique for the management of central airway obstruction, 
foreign body aspiration and massive hemoptysis. Areas covered: This article 
will review the history, indications, contraindication, technique and 
complications of rigid bronchoscopy. We will also briefly discuss the 
methods of anesthesia and ventilation and finally our perspective on the 
future of rigid bronchoscopy. Expert commentary: Although the rise of 
flexible bronchoscopy in the 1960s led to a decline in the use of rigid 
bronchoscopy, the last two decades have witnessed resurgence in its 
popularity. We anticipate that it will remain an important tool used by 
interventional pulmonologists for decades to come. We suggest that 
interventional pulmonologists must have training and develop expertise in 
this technique.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchoscopy; rigid bronchoscope; treatment indication; 
EMTREE MEDICAL INDEX TERMS
  ablation therapy; airway obstruction; artificial ventilation; arytenoid cartilage; biopsy forceps; bronchoplasty; bronchus tumor; cartilage injury; cervical spine; cytoreductive surgery; flexible bronchoscope; foreign body; general anesthesia; grasping forceps; heart arrhythmia; heart muscle ischemia; hemoptysis; history of medicine; human; hypoxemia; jet ventilation; laceration; laryngoscopy; larynx edema; light related phenomena; mouth injury; perforation; pharynx; preoperative evaluation; pulmonologist; respiratory tract injury; respiratory tract intubation; review; rigid telescope; self expandable metallic stent; spinal cord injury; spine disease; tracheostomy; treatment contraindication; videorecording; vocal cord; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29727208 (http://www.ncbi.nlm.nih.gov/pubmed/29727208)
PUI
  L622458766
DOI
  10.1080/17476348.2018.1473037
FULL TEXT LINK
  http://dx.doi.org/10.1080/17476348.2018.1473037
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17476356&id=doi:10.1080%2F17476348.2018.1473037&atitle=Indications+and+complications+of+rigid+bronchoscopy&stitle=Expert+Rev.+Respir.+Med.&title=Expert+Review+of+Respiratory+Medicine&volume=12&issue=6&spage=509&epage=520&aulast=Batra&aufirst=Hitesh&auinit=H.&aufull=Batra+H.&coden=&isbn=&pages=509-520&date=2018&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 83
TITLE
  Heart-Shaped Bilateral Medullary Pyramidal Infarction as a Pathognomonic 
Finding of Anterior Spinal Artery Occlusion
AUTHOR NAMES
  Searcy S.; Akinduro O.O.; Spector A.; Yoon J.W.; Brown B.L.; Freeman W.D.
AUTHOR ADDRESSES
  (Akinduro O.O.; Yoon J.W.; Brown B.L.; Freeman W.D., 
freeman.william1@mayo.edu) Department of Neurologic Surgery, Mayo Clinic, 
4500 San Pablo Rd, Jacksonville, United States.
(Freeman W.D., freeman.william1@mayo.edu) Department of Critical Care 
Medicine, Mayo Clinic, Jacksonville, United States.
(Spector A.; Freeman W.D., freeman.william1@mayo.edu) Department of 
Neurology, Mayo Clinic, Jacksonville, United States.
(Searcy S.) University of Tennessee College of Medicine, Memphis, United 
States.
(Spector A.) Department of Neurology, Duke University Medical Center, 
Durham, United States.
CORRESPONDENCE ADDRESS
  W.D. Freeman, Department of Neurologic Surgery, Mayo Clinic, 4500 San Pablo 
Rd, Jacksonville, United States. Email: freeman.william1@mayo.edu
AiP/IP ENTRY DATE
  2017-05-15
FULL RECORD ENTRY DATE
  2018-07-06
SOURCE
  Neurocritical Care (2018) 28:3 (388-394). Date of Publication: 1 Jun 2018
VOLUME
  28
ISSUE
  3
FIRST PAGE
  388
LAST PAGE
  394
DATE OF PUBLICATION
  1 Jun 2018
ISSN
  1556-0961 (electronic)
  1541-6933
BOOK PUBLISHER
  Humana Press Inc., humana@humanapr.com
ABSTRACT
  Background: Unilateral anterior spinal artery (ASA) occlusion resulting in 
bilateral medullary pyramidal (BMP) infarction is a rare and devastating 
stroke subtype. We present two cases highlighting the diagnostic and 
clinical challenges of BMP infarction. Methods: Case reports and literature 
review. Results: A 57-year-old man rapidly had severe vomiting and diarrhea 
2 h after a meal. Examination revealed bulbar weakness and areflexic 
tetraplegia. Respiratory failure developed, requiring intubation and 
mechanical ventilation. Brain magnetic resonance imaging (MRI) showed a 
heart-shaped region of diffusion abnormality, characteristic of BMP 
infarction. Cerebral angiography showed an occluded left vertebral artery 
with unilateral left-sided origin of ASA. The patient required tracheostomy 
and percutaneous gastrostomy tube and was discharged to rehabilitation, with 
little improvement of his tetraplegia at 3-month follow-up. A 43-year-old 
woman presented to the emergency department with acute onset of 
lower-extremity paresthesia and history of upper respiratory infection 
2 weeks prior. Initial examination findings included bulbar weakness, 
dysphagia, hyporeflexia, and generalized weakness. After admission, she had 
severe respiratory distress and required intubation. Lumbar puncture was 
evaluated for Guillain–Barré syndrome, but cerebrospinal fluid protein 
concentration was normal. Changes on diffusion-weighted MRI of the brain 
showed the characteristic heart-shaped BMP infarction, indicating occlusion 
of a unilateral ASA. She required tracheostomy and percutaneous gastrostomy 
tube placement, with no paralysis resolution. Conclusion: Acute BMP 
infarction may present with flaccid tetraplegia mimicking neuromuscular 
disorders. When the infarction is recognized early, intravenous thrombolysis 
can be considered to reduce morbidity of this rare stroke subtype.
EMTREE DRUG INDEX TERMS
  botulinum antiserum (drug therapy); immunoglobulin (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spinal artery occlusion (diagnosis); bilateral medullary pyramidal infarction (diagnosis); brain infarction (diagnosis); occlusive cerebrovascular disease (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  abnormal respiratory sound; adult; antibiotic therapy; anxiety; article; artificial ventilation; Babinski reflex; botulism (drug therapy); brain angiography; breathing disorder; bronchoscopy; bulbar paralysis; case report; cerebrospinal fluid examination; clinical article; clinical outcome; cognition; coughing; depression; diabetes mellitus; diarrhea; diffusion weighted imaging; drinking behavior; drug response; dysphagia; dysphonia; dyspnea; eye movement; face asymmetry; female; follow up; Guillain Barre syndrome (drug therapy); hospital discharge; human; hypertension; intubation; laboratory test; lumbar puncture; lung lavage; magnetic resonance angiography; male; medical history; middle aged; migraine; morbid obesity; muscle strength; neurologic examination; nuclear magnetic resonance imaging; nursing care; paresthesia; percutaneous endoscopic gastrostomy tube; physical examination; powered wheelchair; priority journal; pseudobulbar palsy; pupil reflex; quadriplegia; rehabilitation; respiratory failure; smoking; tracheostomy; treatment duration; upper respiratory tract infection; vomiting; walking difficulty; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  28484930 (http://www.ncbi.nlm.nih.gov/pubmed/28484930)
PUI
  L616059100
DOI
  10.1007/s12028-017-0406-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12028-017-0406-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15560961&id=doi:10.1007%2Fs12028-017-0406-7&atitle=Heart-Shaped+Bilateral+Medullary+Pyramidal+Infarction+as+a+Pathognomonic+Finding+of+Anterior+Spinal+Artery+Occlusion&stitle=Neurocrit.+Care&title=Neurocritical+Care&volume=28&issue=3&spage=388&epage=394&aulast=Akinduro&aufirst=Oluwaseun+O.&auinit=O.O.&aufull=Akinduro+O.O.&coden=&isbn=&pages=388-394&date=2018&auinit1=O&auinitm=O
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 84
TITLE
  The need for early tracheostomy in patients with traumatic cervical cord 
injury
AUTHOR NAMES
  Beom J.-Y.; Seo H.-Y.
AUTHOR ADDRESSES
  (Beom J.-Y.; Seo H.-Y., osdrseo@gmail.com) Department of Orthopedic Surgery, 
Chonnam National University Hospital, Gwangju, South Korea.
CORRESPONDENCE ADDRESS
  H.-Y. Seo, Department of Orthopedic Surgery, Chonnam National University 
Hospital, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, 
Gwangju, South Korea. Email: osdrseo@gmail.com
AiP/IP ENTRY DATE
  2019-01-23
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  CiOS Clinics in Orthopedic Surgery (2018) 10:2 (191-196). Date of 
Publication: 1 Jun 2018
VOLUME
  10
ISSUE
  2
FIRST PAGE
  191
LAST PAGE
  196
DATE OF PUBLICATION
  1 Jun 2018
ISSN
  2005-4408 (electronic)
  2005-291X
BOOK PUBLISHER
  Korean Orthopaedic Association, ortho@koa.or.kr
ABSTRACT
  Background: In patients who need sustained endotracheal intubation and 
mechanical ventilation due to respiratory failure after traumatic cervical 
spinal cord injury, tracheostomy can be performed to reduce the duration of 
mechanical ventilation and respiratory complications. The purpose of this 
study was to determine criteria and timing of tracheostomy in patients with 
severe traumatic cervical spinal cord injury accompanied by motor weakness. 
Methods: We reviewed 22 patients who underwent tracheostomy (study group) 
and 27 patients who did not (control group) from January 2005 to March 2016. 
We assessed the American Spinal Injury Association (ASIA) impairment scale 
score and investigated accompanying thoracic injury, paradoxical 
respiration, postoperative endotracheal intubation and other clinical 
parameters. The study group was also subdivided into the early tracheostomy 
group and late tracheostomy group depending on whether the tracheostomy was 
performed within or later than 7 days after surgery. Results: Twenty-two 
patients in the study group had a mean ASIA impairment scale score of 14.1 
points, which was lower than the control group’s 23.4 points. Paradoxical 
respiration was observed in 77% of the patients in the study group compared 
to 18% in the control group. Postoperative intubation was maintained in 68% 
in the study group; 32% underwent endotracheal intubation due to respiratory 
failure within 4 days after surgery and had a tracheostomy. In the control 
group, postoperative intubation was maintained in 22%, and all of them were 
weaned off intubation within 4 days after surgery. The duration of intensive 
care unit hospitalization was 11.4 days for the early tracheostomy group, 
which was shorter than the late tracheostomy group’s 19.7 days. Conclusions: 
In patients with severe traumatic cervical spinal cord injury, tracheostomy 
may be needed when the motor grade of the ASIA scale is low, above the C4 
segment is injured, or paradoxical respiration occurs after injuries. In 
addition, if endotracheal extubation is not feasible within 4 days after 
surgery, an early tracheostomy should be considered.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); early intervention; tracheostomy; traumatic cervical cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; article; clinical article; clinical effectiveness; controlled study; endotracheal intubation; female; human; length of stay; male; middle aged; outcome assessment; respiratory failure (therapy); time to treatment; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29854342 (http://www.ncbi.nlm.nih.gov/pubmed/29854342)
PUI
  L625771308
DOI
  10.4055/cios.2018.10.2.191
FULL TEXT LINK
  http://dx.doi.org/10.4055/cios.2018.10.2.191
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20054408&id=doi:10.4055%2Fcios.2018.10.2.191&atitle=The+need+for+early+tracheostomy+in+patients+with+traumatic+cervical+cord+injury&stitle=CIOS+Clin.+Orthop.+Surg.&title=CiOS+Clinics+in+Orthopedic+Surgery&volume=10&issue=2&spage=191&epage=196&aulast=Beom&aufirst=Jae-Young&auinit=J.-Y.&aufull=Beom+J.-Y.&coden=&isbn=&pages=191-196&date=2018&auinit1=J&auinitm=-Y
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 85
TITLE
  Nusinersen in infants who initiate treatment in a presymptomatic stage of 
spinal muscular atrophy (SMA): Interim results from the Phase 2 NURTURE 
study
AUTHOR NAMES
  De Vivo D.C.; Bertini E.; Hwu W.; Foster R.; Bhan I.; Gheuens S.; Farwell W.; Reyna S.P.; Vajsar J.
AUTHOR ADDRESSES
  (De Vivo D.C.) New York, United States.
(Bertini E.) Rome, Italy.
(Hwu W.) Taipei, Taiwan.
(Foster R.) Maidenhead, United Kingdom.
(Bhan I.; Gheuens S.; Farwell W.; Reyna S.P.) Cambridge, United Kingdom.
(Vajsar J.) Toronto, Canada.
CORRESPONDENCE ADDRESS
  D.C. De Vivo, New York, United States.
FULL RECORD ENTRY DATE
  2018-08-07
SOURCE
  Canadian Journal of Neurological Sciences (2018) 45 Supplement 2 (S12-S13). 
Date of Publication: 1 Jun 2018
VOLUME
  45
FIRST PAGE
  S12
LAST PAGE
  S13
DATE OF PUBLICATION
  1 Jun 2018
CONFERENCE NAME
  53rd Annual Congress of the Canadian Neurological Sciences Federation
CONFERENCE LOCATION
  Halifax, NS, Canada
CONFERENCE DATE
  2018-06-24 to 2018-06-27
ISSN
  0317-1671
BOOK PUBLISHER
  Cambridge University Press
ABSTRACT
  Background: NURTURE (NCT02386553) is an ongoing openlabel single-arm 
efficacy/safety study of intrathecal nusinersen in infants who initiate 
treatment in a presymptomatic stage of spinal muscular atrophy (SMA). 
Methods: Enrolled infants were age ≤6 weeks at first dose, clinically 
presymptomatic, had genetically diagnosed SMA, and 2 or 3 copies of SMN2. 
Primary endpoint is time to death or respiratory intervention (≥6 hours/day 
continuously for ≥7 days or tracheostomy). Results: As of July 5, 2017, 25 
infants (2 copies SMN2, n=15;3 copies, n=10) were enrolled. All infants were 
alive. Two infants (both with 2 copies SMN2) required respiratory 
intervention (but not tracheostomy or permanent ventilation) during an 
acute, reversible viral infection and thus met the primary endpoint. At last 
visit, 22/24 (92%) infants had achieved WHO motor milestones sitting without 
support and 8/16 (50%;2 SMN2, n=3/11;3 SMN2, n=5/5) on study >13 months 
achieved walking alone. AEs were reported in 24/25 (96%) infants; most 20/25 
(80%) had AEs that were mild/moderate in severity; 9 had serious AEs. Four 
infants had an AE possibly related to study drug, which resolved despite 
continued treatment. No new safety concerns were identified. Conclusions: 
Nusinersen continued to benefit infants who initiated treatment in a 
presymptomatic stage of SMA.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE DRUG INDEX TERMS
  endogenous compound; survival motor neuron protein 2; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy type 2; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; case report; clinical article; conference abstract; death; diagnosis; drug therapy; female; human; infant; male; phase 2 clinical trial; tracheostomy; virus infection; walking; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623322556
DOI
  10.1017/cjn.2018.93
FULL TEXT LINK
  http://dx.doi.org/10.1017/cjn.2018.93
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03171671&id=doi:10.1017%2Fcjn.2018.93&atitle=Nusinersen+in+infants+who+initiate+treatment+in+a+presymptomatic+stage+of+spinal+muscular+atrophy+%28SMA%29%3A+Interim+results+from+the+Phase+2+NURTURE+study&stitle=Can.+J.+Neurol.+Sci.&title=Canadian+Journal+of+Neurological+Sciences&volume=45&issue=&spage=S12&epage=S13&aulast=De+Vivo&aufirst=D.C.&auinit=D.C.&aufull=De+Vivo+D.C.&coden=&isbn=&pages=S12-S13&date=2018&auinit1=D&auinitm=C
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 86
TITLE
  Nusinersen and early physiotherapy in patients with spinal muscular atrophy 
type 1: Case series
AUTHOR NAMES
  Bazancir Z.; Aslan M.; Bözgör B.; Güngör S.; Talu B.
AUTHOR ADDRESSES
  (Bazancir Z.; Talu B.) Inonu University, Faculty of Health Science, 
Physiotherapy and Rehabilitation Department, Turkey.
(Aslan M.; Bözgör B.; Güngör S.) Inonu University, Faculty of Medicine, 
Pediatric Neurology Department, Turkey.
CORRESPONDENCE ADDRESS
  Z. Bazancir, Inonu University, Faculty of Health Science, Physiotherapy and 
Rehabilitation Department, Turkey.
FULL RECORD ENTRY DATE
  2018-07-26
SOURCE
  Acta Myologica (2018) 37:2 (182-183). Date of Publication: 1 Jun 2018
VOLUME
  37
ISSUE
  2
FIRST PAGE
  182
LAST PAGE
  183
DATE OF PUBLICATION
  1 Jun 2018
CONFERENCE NAME
  13th Meeting of the Mediterrranean Society of Myology, MSM 2018
CONFERENCE LOCATION
  Avanos, Turkey
CONFERENCE DATE
  2018-06-27 to 2018-06-29
ISSN
  2532-1900
BOOK PUBLISHER
  Pacini Editore S.p.A.
ABSTRACT
  Objectives. To evaluate effects of combined of nusinersen and early 
physiotherapy on functional performance, respiratory and nutritional status 
in four cases with SMA type 1. Method. The children was three females and 
one male, aged from 10 month to 5 years 9 month. One patient used nasal 
CPAP, 3 patients benefited from mechanical ventilation with tracheotomy and 
one patient had gastrostomy at baseline. All patients underwent a 
physiotherapeutic evaluation at the time of the first consultation 
(pre-treatment) as well as on the follow up-visit (8 week intervals for 24 
weeks). CHOP INTEND is used to evaluate functional performance. The primary 
endpoint of cases was change in CHOP INTEND score from baseline. As 
secondary endpoint, we evaluated changes in respiratory and nutritional 
status as well as parents' impression regarding improvements or worsening in 
motor and respiratory function. To evaluate parents' impression, we used a 
Likert scale with five categories. Intrathecal Nusinersen was applied 4 
doses. Physiotherapy program were done 2 days in a week for 24 week 
supervised by physiotherapist and home exercises were given on other days. 
Results. After 4 doses nusinersen and early physiotherapy, mean improvement 
of CHOP INTEND score was 10.7 ± 2.21 points, MV pressure was reduced three 
patient, a patient was observed to need nasal CPAP during sleep only. 
Nutritional status and parents' impression were improved. Parents of 3 
children reported a marked improvement and parents of 1 children a slight 
improvement in motor function, regarding respiratory function an 
improvement, parents of 3 children a marked improvement and parent of 1 
children did not observe a change. Conclusions. Depending the improvements 
after nusinersen and early physiotherapy, we believe that the prospective 
follow up of this data will bring information about benefit ratio of 
nusinersen and early physiotherapy in this population.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case study; physiotherapy; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  case report; child; clinical article; clinical evaluation; conference abstract; consultation; drug therapy; exercise; female; follow up; gastrostomy; human; Likert scale; male; motor performance; nutritional status; physiotherapist; positive end expiratory pressure; preschool child; prospective study; respiratory function; sleep; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623151842
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=25321900&id=doi:&atitle=Nusinersen+and+early+physiotherapy+in+patients+with+spinal+muscular+atrophy+type+1%3A+Case+series&stitle=Acta+Myologica&title=Acta+Myologica&volume=37&issue=2&spage=182&epage=183&aulast=Bazancir&aufirst=Z.&auinit=Z.&aufull=Bazancir+Z.&coden=&isbn=&pages=182-183&date=2018&auinit1=Z&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 87
TITLE
  The natural course of dysphagia in ALS is different between patients with 
bulbar and spinal onset
AUTHOR NAMES
  Torrieri M.C.; Manera U.; D'ovidio F.; Calvo A.; Moglia C.; Cammarosano S.; Ilardi A.; Canosa A.; Bersano E.; Mazzini L.; Chiò A.
AUTHOR ADDRESSES
  (Torrieri M.C.; Manera U.; D'ovidio F.; Calvo A.; Moglia C.; Cammarosano S.; 
Ilardi A.; Canosa A.; Chiò A.) Rita Levi Montalcini Department of 
Neuroscience, University of Turin, Turin, Italy.
(Bersano E.; Mazzini L.) Amyotrophic Lateral Sclerosis Center, Department of 
Neurology, Azienda Ospedaliero Universitaria Maggiore di Novara, Novara, 
Italy.
CORRESPONDENCE ADDRESS
  M.C. Torrieri, Rita Levi Montalcini Department of Neuroscience, University 
of Turin, Turin, Italy.
FULL RECORD ENTRY DATE
  2018-08-06
SOURCE
  European Journal of Neurology (2018) 25 Supplement 2 (512). Date of 
Publication: 1 Jun 2018
VOLUME
  25
FIRST PAGE
  512
DATE OF PUBLICATION
  1 Jun 2018
CONFERENCE NAME
  4th Congress of the European Academy of Neurology, EAN 2018
CONFERENCE LOCATION
  Lisbon, Portugal
CONFERENCE DATE
  2018-06-16 to 2018-06-19
ISSN
  1468-1331
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Background and aims: We aimed at evaluating the relationship between 
dysphagia and site of onset in amyotrophic lateral sclerosis (ALS) in terms 
of progression rate. Methods: We enrolled 871 incident ALS patients (580 
with spinal onset, 291 with bulbar onset), resident in Piemonte and Valle 
d'Aosta, Italy, from 2007 to 2013. Based on ALSFRS-R item 3, dysphagia was 
classified as “severe” (0-1), “moderate” (2-3), “absent” (4). The 
progression of dysphagia was considered as time-dependent variable and was 
reassessed at each visit. Progression rate of dysphagia was calculated 
separately among patients with bulbar and spinal onset (N=642). Time 
intervals ended with the date when dysphagia became severe. The starting 
date was the date of onset for bulbar patients (N=279) and the date of first 
bulbar symptoms (considering ALSFRS-R items 1 and 3<4) for spinal patients 
(N=363). 217 patients did not develop dysphagia during the follow-up. 
Results: ALS patients showed moderate dysphagia after a median of 24.4 
months (IQR=13.5-44.7) from the onset. Dysphagia became severe after 
additional 17.7 months (IQR=9.5-29.8); death/tracheostomy occurred after 
additional 6.9 months (IQR=2.6-14.7). The progression rate showed a median 
time interval of 17.4 months (IQR=8.9-29.5) between the first bulbar symptom 
and severe dysphagia. These time intervals were shorter in patients with 
spinal onset (median 11.9 months; IQR=5.5-24.1) than in cases with bulbar 
onset (22.9 months; IQR=16.0-31.8) (Wilcoxon test p=0.000). Conclusion: The 
progression rate of dysphagia significantly differs between ALS patients 
with bulbar and spinal onset.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia; 
EMTREE MEDICAL INDEX TERMS
  adult; amyotrophic lateral sclerosis; Aosta Valley; conference abstract; controlled study; death; dependent variable; disease course; female; follow up; human; major clinical study; male; rank sum test; resident; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623298549
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14681331&id=doi:&atitle=The+natural+course+of+dysphagia+in+ALS+is+different+between+patients+with+bulbar+and+spinal+onset&stitle=Eur.+J.+Neurol.&title=European+Journal+of+Neurology&volume=25&issue=&spage=512&epage=&aulast=Torrieri&aufirst=M.C.&auinit=M.C.&aufull=Torrieri+M.C.&coden=&isbn=&pages=512-&date=2018&auinit1=M&auinitm=C
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 88
TITLE
  Cluster of acute flaccid myelitis associated with enterovirus d68 (EV-D68) 
in five children in South East Scotland, september-october 2016
AUTHOR NAMES
  Chinchankar N.; Kirolos A.; Mark K.; McDougall C.; Shetty J.; Templeton K.; Pilley E.; Stevenson J.; Eunson P.; Waugh C.
AUTHOR ADDRESSES
  (Chinchankar N.; McDougall C.) NHS Lothian, Paediatric Intensive Care-Royal 
Hospital for Sick Children, Edinburgh, United Kingdom.
(Kirolos A.; Mark K.; Stevenson J.; Waugh C.) NHS Lothian, Directorate of 
Public Health and Health Policy, Edinburgh, United Kingdom.
(Shetty J.) NHS Lothian, Department of Paediatrics-Royal Hospital for Sick 
Children, Edinburgh, United Kingdom.
(Templeton K.) NHS Lothian, Department of Virology-Edinburgh Royal 
Infirmary, Edinburgh, United Kingdom.
(Pilley E.; Eunson P.) NHS Lothian, Department of Paediatric-Royal Hospital 
for Sick Children, Edinburgh, United Kingdom.
CORRESPONDENCE ADDRESS
  N. Chinchankar, NHS Lothian, Paediatric Intensive Care-Royal Hospital for 
Sick Children, Edinburgh, United Kingdom.
FULL RECORD ENTRY DATE
  2018-09-13
SOURCE
  Pediatric Critical Care Medicine (2018) 19:6 Supplement 1 (250-251). Date of 
Publication: 1 Jun 2018
VOLUME
  19
ISSUE
  6
FIRST PAGE
  250
LAST PAGE
  251
DATE OF PUBLICATION
  1 Jun 2018
CONFERENCE NAME
  9th Congress of the World Federation of Pediatric Intensive and Critical 
Care Societies, WFPICCS 2018
CONFERENCE LOCATION
  Singapore, Singapore
CONFERENCE DATE
  2018-06-09 to 2018-06-13
ISSN
  1947-3893
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Aims & Objectives: We aim to describe the clinical presentation, 
epidemiology and long term followup of five cases presenting with acute 
flaccid myelitis (AFM) due to enterovirus D68 (EV-D68) Methods After the 
index case was diagnosed a multidisciplinary Incident management team was 
convened to identify possible cases of AFM. Suspected cases were 
investigated with nasopharyngeal secretion (NPS) testing and MRI. Results 
Five children, positive for EV-D68 on NPS presented with asymmetrical limb 
weakness, decreased truncal tone and reduced reflexes. MRI of the brain and 
spinal cord demonstrated abnormal high T2 signal in the dorsal pons, medulla 
and spinal cord grey matter, with predominance in the cervical spinal cord. 
Nerve conduction studies carried out on two of the most severely affected 
cases showed evidence of acute motor neuropathy. (Figure prsented). 
Conclusions This was the largest paediatric cluster of AFM associated with 
EV-D68 in Europe and the first to have affected Scotland. Patients were aged 
between 2-6 years old. Two children had complications of autonomic 
involvement with hypertension and evidence of end organ damage. All cases 
suffered from limb pain which responded to Gabapentin. Three patients had 
bulbar involvement, 2 of whom required intubation, ventilation and intensive 
care management. These 2 children then went on to require tracheostomies and 
long term home ventilation. All the 5 children have required and continue to 
require ongoing community rehabilitation due to persistent neurological 
deficits.
EMTREE DRUG INDEX TERMS
  gabapentin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Enterovirus D68; myelitis; Scotland; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; case report; cervical spinal cord; child; clinical article; complication; conference abstract; diagnosis; female; follow up; gray matter; human; hypertension; intubation; limb pain; limb weakness; male; medulla oblongata; motor neuropathy; nerve conduction; nonhuman; nuclear magnetic resonance imaging; organ injury; pons; preschool child; reflex; rehabilitation; tracheostomy; 
CAS REGISTRY NUMBERS
  gabapentin (60142-96-3)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623815577
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19473893&id=doi:&atitle=Cluster+of+acute+flaccid+myelitis+associated+with+enterovirus+d68+%28EV-D68%29+in+five+children+in+South+East+Scotland%2C+september-october+2016&stitle=Pediatr.+Crit.+Care+Med.&title=Pediatric+Critical+Care+Medicine&volume=19&issue=6&spage=250&epage=251&aulast=Chinchankar&aufirst=N.&auinit=N.&aufull=Chinchankar+N.&coden=&isbn=&pages=250-251&date=2018&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 89
TITLE
  Pial arteriovenous fistula of the spine in a child with hemiplegia
AUTHOR NAMES
  Hatayama K.; Goto S.; Nishida A.; Inoue M.
AUTHOR ADDRESSES
  (Hatayama K.; Goto S.; Inoue M., masanamimoe@yahoo.co.jp) Department of 
Pediatrics, Okayama Red-Cross Hospital, Okayama, Japan.
(Nishida A.) Department of Neuroendovascular Therapy, Okayama Red-Cross 
Hospital, Okayama, Japan.
CORRESPONDENCE ADDRESS
  M. Inoue, Department of Pediatrics, Okayama Red-Cross Hospital, Okayama, 
Japan. Email: masanamimoe@yahoo.co.jp
AiP/IP ENTRY DATE
  2018-05-03
FULL RECORD ENTRY DATE
  2018-06-20
SOURCE
  Clinical Case Reports (2018) 6:6 (1132-1136). Date of Publication: 1 Jun 
2018
VOLUME
  6
ISSUE
  6
FIRST PAGE
  1132
LAST PAGE
  1136
DATE OF PUBLICATION
  1 Jun 2018
ISSN
  2050-0904 (electronic)
BOOK PUBLISHER
  Wiley-Blackwell Publishing Ltd, info@royensoc.co.uk
ABSTRACT
  Pial arteriovenous fistula (AVF) is an extremely rare disease in children. 
When a child presents with sudden onset of hemiparesis and headache, it is 
very important to perform spinal magnetic resonance imaging (MRI) scanning 
for early diagnosis and treatment.
EMTREE DRUG INDEX TERMS
  immunoglobulin (drug therapy, intravenous drug administration); mannitol; poliomyelitis vaccine (drug therapy); steroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arteriovenous fistula (diagnosis); hemiplegia (drug therapy, diagnosis, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; case report; child; clinical article; computer assisted tomography; consciousness; digital subtraction angiography; dyspnea; edema; follow up; guiding catheter; headache; human; intensive care unit; lumbar puncture; male; motor performance; neurologic examination; nuclear magnetic resonance imaging; posterior inferior cerebellar artery; preschool child; priority journal; quadriplegia; spinal hematoma; tracheostomy; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
  mannitol (69-65-8, 87-78-5)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180303559
PUI
  L621913347
DOI
  10.1002/ccr3.1557
FULL TEXT LINK
  http://dx.doi.org/10.1002/ccr3.1557
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20500904&id=doi:10.1002%2Fccr3.1557&atitle=Pial+arteriovenous+fistula+of+the+spine+in+a+child+with+hemiplegia&stitle=Clin.+Case+Rep.&title=Clinical+Case+Reports&volume=6&issue=6&spage=1132&epage=1136&aulast=Hatayama&aufirst=Kazuki&auinit=K.&aufull=Hatayama+K.&coden=&isbn=&pages=1132-1136&date=2018&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 90
TITLE
  Cervical spine osteomyelitis in head and neck cancer patients: Looking twice 
for posterior hypopharyngeal dehiscence
AUTHOR NAMES
  Clifton W.E.; Gupta V.; Prause C.; Vibhute P.G.
AUTHOR ADDRESSES
  (Clifton W.E.) Department of Neurosurgery, Mayo Clinic, Jacksonville, United 
States.
(Gupta V., gupta.vivek@mayo.edu; Prause C.; Vibhute P.G.) Department of and 
Radiology, Mayo Clinic, Jacksonville, United States.
CORRESPONDENCE ADDRESS
  V. Gupta, Department of Radiology, Mayo Clinic, 4500 San Pablo Rd, 
Jacksonville, United States. Email: gupta.vivek@mayo.edu
AiP/IP ENTRY DATE
  2017-09-05
FULL RECORD ENTRY DATE
  2018-06-08
SOURCE
  Radiology of Infectious Diseases (2018) 5:2 (81-84). Date of Publication: 1 
Jun 2018
VOLUME
  5
ISSUE
  2
FIRST PAGE
  81
LAST PAGE
  84
DATE OF PUBLICATION
  1 Jun 2018
ISSN
  2352-6211
BOOK PUBLISHER
  Beijing You'an Hospital
ABSTRACT
  Cervical spinal osteomyelitis due to breakdown of the posterior wall of the 
hypopharynx is a rare complication following surgery and adjuvant radiation 
or chemotherapy of head and neck cancer. Very few such cases have been 
reported in literature. We report 2 cases of cervical spine osteomyelitis in 
head and neck cancer patients due to posterior hypopharyngeal dehiscence. In 
the first patient, a 74 year old woman with total laryngectomy performed 12 
years ago; the osteomyelitis followed an iatrogenic tear from balloon 
dilatation of a chronic radiation induced neopharyngeal stricture. There was 
a slit-like defect on MRI in the posterior wall at the junction of the 
neopharynx and esophagus immediately anterior to C5-6 osteomyelitis. The 
second, a 53 year old male patient developed this complication from a 
spontaneous breakdown of the posterior hypopharynx 4 months after completing 
chemoradiation for tonsillar cancer. There was failure to recognize the 
sinus tract on the immediate post-treatment neck CT which predated the onset 
of osteomyelitis. Both patients were treated with broad spectrum antibiotic 
therapy and discontinuation of oral feeding. Awareness and diligent 
detection of hypopharyngeal dehiscence is important in cases of cervical 
spinal osteomyelitis occurring in head and neck cancer patients.
EMTREE DRUG INDEX TERMS
  amoxicillin plus clavulanic acid (drug therapy); antibiotic agent (drug therapy); ceftriaxone (drug therapy, intravenous drug administration); doxycycline (drug therapy); fluconazole (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine osteomyelitis (drug therapy, complication, drug therapy, 
surgery); head and neck cancer (radiotherapy); osteomyelitis (drug therapy, complication, drug therapy, surgery); wound dehiscence; Zenker diverticulum; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; balloon dilatation; cancer radiotherapy; case report; clinical article; esophagus; esophagus stenosis; feeding; female; gastrostomy; granulation tissue; human; human tissue; hypopharynx; laryngectomy; male; metastasis; middle aged; nuclear magnetic resonance imaging; tonsillectomy; tracheostomy; x-ray computed tomography; 
CAS REGISTRY NUMBERS
  amoxicillin plus clavulanic acid (74469-00-4, 79198-29-1)
  ceftriaxone (73384-59-5, 74578-69-1)
  doxycycline (10592-13-9, 17086-28-1, 564-25-0, 94088-85-4)
  fluconazole (86386-73-4)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Immunology, Serology and Transplantation (26)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170614628
PUI
  L618068186
DOI
  10.1016/j.jrid.2017.07.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jrid.2017.07.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23526211&id=doi:10.1016%2Fj.jrid.2017.07.002&atitle=Cervical+spine+osteomyelitis+in+head+and+neck+cancer+patients%3A+Looking+twice+for+posterior+hypopharyngeal+dehiscence&stitle=Radiol.+Infect.+Dis.&title=Radiology+of+Infectious+Diseases&volume=5&issue=2&spage=81&epage=84&aulast=Clifton&aufirst=William+E.&auinit=W.E.&aufull=Clifton+W.E.&coden=&isbn=&pages=81-84&date=2018&auinit1=W&auinitm=E
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 91
TITLE
  Amyotrophic Lateral Sclerosis and the Respiratory System
AUTHOR NAMES
  Braun A.T.; Caballero-Eraso C.; Lechtzin N.
AUTHOR ADDRESSES
  (Braun A.T.; Caballero-Eraso C.; Lechtzin N., nlechtz@jhmi.edu) Division of 
Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, 
Johns Hopkins University School of Medicine, 1830 East Monument Street, 
Baltimore, United States.
(Braun A.T.) Division of Allergy, Pulmonary, and Critical Care, Department 
of Medicine, University of Wisconsin School of Medicine and Public Health, 
600 Highland Avenue, Madison, United States.
(Caballero-Eraso C.) Medical-Surgical Unit of Respiratory Diseases, 
Institute of Biomedicine of Seville (IBiS), Centre for Biomedical Research 
in Respiratory Diseases Network (CIBERES), University Hospital Virgen del 
Rocío, University of Seville, Avenida Dr. Fedriani, Sevilla, Spain.
CORRESPONDENCE ADDRESS
  N. Lechtzin, 1830 East Monument Street, 5th Floor, Baltimore, United States. 
Email: nlechtz@jhmi.edu
AiP/IP ENTRY DATE
  2018-05-25
FULL RECORD ENTRY DATE
  2018-06-06
SOURCE
  Clinics in Chest Medicine (2018) 39:2 (391-400). Date of Publication: 1 Jun 
2018
VOLUME
  39
ISSUE
  2
FIRST PAGE
  391
LAST PAGE
  400
DATE OF PUBLICATION
  1 Jun 2018
ISSN
  1557-8216 (electronic)
  0272-5231
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative 
disorder that always affects the respiratory muscles. It is characterized by 
degeneration of motor neurons in the brain and spinal cord. Respiratory 
complications are the most common causes of death in ALS and typically occur 
within 3 to 5 years of diagnosis. Because ALS affects both upper and lower 
motor neurons, it causes hyperreflexia, spasticity, muscle fasciculations, 
muscle atrophy, and weakness. It ultimately progresses to functional 
quadriplegia. ALS most commonly begins in the limbs, but in about one-third 
of cases it begins in the bulbar muscles responsible for speech and 
swallowing.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (diagnosis); lung disease (complication, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  abdominal disease; artificial ventilation; breathing muscle; bronchus secretion; bulbar innervated muscle dysfunction (complication); cardiac rhythm management device; chest wall oscillation; coughing; daytime somnolence; diaphragmatic pacemaker; dyspnea; expiratory muscle weakness (complication); fasciculation; headache; human; hyperreflexia; inspiratory muscle weakness (complication); lung function test; maximal expiratory pressure; maximal inspiratory pressure; motoneuron; muscle atrophy; muscle weakness (complication); noninvasive ventilation; orthopnea; overall survival; oximetry; palliative therapy; pneumonia (prevention); polysomnography; positive end expiratory pressure; priority journal; quality of life; review; risk reduction; sleep disorder; spasticity; speech disorder; tachypnea; terminal care; tracheostomy; vaccination; ventilator weaning; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29779597 (http://www.ncbi.nlm.nih.gov/pubmed/29779597)
PUI
  L2000767803
DOI
  10.1016/j.ccm.2018.01.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ccm.2018.01.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15578216&id=doi:10.1016%2Fj.ccm.2018.01.003&atitle=Amyotrophic+Lateral+Sclerosis+and+the+Respiratory+System&stitle=Clin.+Chest+Med.&title=Clinics+in+Chest+Medicine&volume=39&issue=2&spage=391&epage=400&aulast=Braun&aufirst=Andrew+T.&auinit=A.T.&aufull=Braun+A.T.&coden=CCHMD&isbn=&pages=391-400&date=2018&auinit1=A&auinitm=T
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 92
TITLE
  Progress in the Treatment of Patients with Neuromuscular and Nonmuscular 
Chest Wall Diseases
AUTHOR NAMES
  McCool F.D.; Benditt J.O.
AUTHOR ADDRESSES
  (McCool F.D., F_McCool@brown.edu) The Warren Alpert Medical School of Brown 
University, Memorial Hospital of Rhode Island, 111 Brewster Street, 
Pawtucket, United States.
(Benditt J.O., benditt@uw.edu) University of Washington, School of Medicine, 
UWMC, Box 356522, 1959 Northeast Pacific Street, Seattle, United States.
EDITORS
  Colinet P.; Lambert P.
AiP/IP ENTRY DATE
  2018-05-24
FULL RECORD ENTRY DATE
  2018-05-31
SOURCE
  Clinics in Chest Medicine (2018) 39:2 (xv-xvi). Date of Publication: 1 Jun 
2018
VOLUME
  39
ISSUE
  2
FIRST PAGE
  xv
LAST PAGE
  xvi
DATE OF PUBLICATION
  1 Jun 2018
ISSN
  1557-8216 (electronic)
  0272-5231
ISBN
  9780323583923 (volume)
BOOK PUBLISHER
  W.B. Saunders
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neuromuscular disease; thorax disease; 
EMTREE MEDICAL INDEX TERMS
  cause of death; disability; Duchenne muscular dystrophy; editorial; human; kyphoscoliosis; morbidity; mortality; noninvasive ventilation; obesity hypoventilation syndrome; pneumonia; priority journal; respiratory failure; sleep disordered breathing; spinal cord injury; survival rate; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  29779604 (http://www.ncbi.nlm.nih.gov/pubmed/29779604)
PUI
  L2000767805
DOI
  10.1016/j.ccm.2018.03.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ccm.2018.03.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15578216&id=doi:10.1016%2Fj.ccm.2018.03.001&atitle=Progress+in+the+Treatment+of+Patients+with+Neuromuscular+and+Nonmuscular+Chest+Wall+Diseases&stitle=Clin.+Chest+Med.&title=Clinics+in+Chest+Medicine&volume=39&issue=2&spage=xv&epage=xvi&aulast=McCool&aufirst=F.+Dennis&auinit=F.D.&aufull=McCool+F.D.&coden=CCHMD&isbn=printvolume9780323583923&pages=xv-xvi&date=2018&auinit1=F&auinitm=D
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 93
TITLE
  Cervical spine injury from unrecognized craniocervical instability in severe 
pierre robin sequence associated with skeletal dysplasia
AUTHOR NAMES
  Zhu X.; Evans K.N.; El-Gharbawy A.; Lee J.Y.; Brooker J.E.; Jabbour N.; Tyler-Kabara E.C.; Madan-Khertarpal S.; Losee J.E.; Goldstein J.A.
AUTHOR ADDRESSES
  (Zhu X.; Lee J.Y.; Brooker J.E.; Losee J.E.; Goldstein J.A., 
jesse.goldstein@chp.edu) Division of Pediatric Plastic Surgery, University 
of Pittsburgh School of Medicine, Pittsburgh, United States.
(Evans K.N.) Division of Craniofacial Medicine, University of Washington 
School of Medicine, Seattle, United States.
(El-Gharbawy A.; Madan-Khertarpal S.) Division of Medical Genetics, 
University of Pittsburgh School of Medicine, Pittsburgh, United States.
(Jabbour N.) Division of Pediatric Otolaryngology, University of Pittsburgh 
School of Medicine, Pittsburgh, United States.
(Tyler-Kabara E.C.) Division of Pediatric Neurological Surgery, University 
of Pittsburgh School of Medicine, Pittsburgh, United States.
CORRESPONDENCE ADDRESS
  J.A. Goldstein, Faculty Pavilion, One Children’s Hospital Drive, 4401 Penn 
Avenue, 7th Floor, Pittsburgh, United States. Email: jesse.goldstein@chp.edu
AiP/IP ENTRY DATE
  2018-06-21
FULL RECORD ENTRY DATE
  2018-06-26
SOURCE
  Cleft Palate-Craniofacial Journal (2018) 55:5 (773-777). Date of 
Publication: 1 May 2018
VOLUME
  55
ISSUE
  5
FIRST PAGE
  773
LAST PAGE
  777
DATE OF PUBLICATION
  1 May 2018
ISSN
  1545-1569 (electronic)
  1055-6656
BOOK PUBLISHER
  SAGE Publications Ltd, info@sagepub.co.uk
ABSTRACT
  Pierre Robin Sequence (PRS) can be associated with skeletal dysplasias, 
presenting with craniocervical instability and devastating spinal injury if 
unrecognized. The authors present the case of an infant with PRS and a type 
II collagenopathy who underwent multiple airway-securing procedures 
requiring spinal manipulation before craniocervical instability was 
identified. This resulted in severe cervical cord compression due to 
odontoid fracture and occipitoatlantoaxial instability. This case highlights 
the importance of early cervical spine imaging and cautious manipulation in 
infants with PRS and suspected skeletal dysplasia.
EMTREE DRUG INDEX TERMS
  collagen 2a1 (endogenous compound); collagen type 2 (endogenous compound); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantooccipital joint; cervical spine injury (complication); Pierre Robin syndrome; spine instability; spondyloepiphyseal dysplasia (diagnosis); spondyloepiphyseal dysplasia congenita (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  airway obstruction; alkalemia; apnea hypopnea index; article; brain ventricle dilatation; bronchoscopy; case report; cervical collar; cervical spine; chondropathy; cleft palate (surgery); clinical article; clonus; computer assisted tomography; disease association; disease severity; distraction osteogenesis; electrolyte disturbance; endotracheal anesthesia; endotracheal intubation; extubation; failure to thrive; feeding difficulty; fetus echography; food aversion; gastroesophageal reflux; gastrostomy; gene mutation; general anesthesia; glossoptosis; halo brace; human; hyperreflexia; hypocapnia; infant; laminectomy; laryngomalacia; laryngoscopy; larynx surgery; male; micrognathia; nasal cannula; neurologic examination; nuclear magnetic resonance imaging; occupational therapy; odontoid process fracture; odontoidectomy; oxygen desaturation; palatoplasty; physiotherapy; plastic surgery; polysomnography; priority journal; quadriplegia; respiratory distress; short stature; sleep disordered breathing (therapy); spasticity; speech therapy; spinal cord compression (surgery); spinal cord decompression; spinal cord injury; spine surgery; stomach fundoplication; stomach tube; subdural hematoma; subglottic stenosis; supraglottoplasty; synchondrosis; tongue collapse; tongue disease; tracheostomy; ventilator weaning; vertebral canal stenosis; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29489401 (http://www.ncbi.nlm.nih.gov/pubmed/29489401)
PUI
  L622616813
DOI
  10.1177/1055665618758102
FULL TEXT LINK
  http://dx.doi.org/10.1177/1055665618758102
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15451569&id=doi:10.1177%2F1055665618758102&atitle=Cervical+spine+injury+from+unrecognized+craniocervical+instability+in+severe+pierre+robin+sequence+associated+with+skeletal+dysplasia&stitle=Cleft+Palate-Craniofac.+J.&title=Cleft+Palate-Craniofacial+Journal&volume=55&issue=5&spage=773&epage=777&aulast=Zhu&aufirst=Xiao&auinit=X.&aufull=Zhu+X.&coden=CPJOE&isbn=&pages=773-777&date=2018&auinit1=X&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 94
TITLE
  Outcomes for patients with Guillain Barre Syndrome transferred to a new 
weaning and long-term ventilation service in Liverpool, UK
AUTHOR NAMES
  Parker R.; Ford V.; Ward K.; Ashcroft H.; Duffy N.; Chakrabarti B.; Angus R.
AUTHOR ADDRESSES
  (Parker R.; Ford V.; Ward K.; Ashcroft H.; Duffy N.; Chakrabarti B.; Angus 
R.) Liverpool Sleep and Ventilation Centre, Aintree University Hospital, 
Liverpool, United Kingdom.
(Parker R.) Critical Care Department, Aintree University Hospital, 
Liverpool, United Kingdom.
CORRESPONDENCE ADDRESS
  R. Parker, Liverpool Sleep and Ventilation Centre, Aintree University 
Hospital, Liverpool, United Kingdom.
FULL RECORD ENTRY DATE
  2018-08-03
SOURCE
  Journal of the Intensive Care Society (2018) 19:2 Supplement 1 (18). Date of 
Publication: 1 May 2018
VOLUME
  19
ISSUE
  2
FIRST PAGE
  18
DATE OF PUBLICATION
  1 May 2018
CONFERENCE NAME
  Intensive Care Society State of the Art, ICS 2017
CONFERENCE LOCATION
  Liverpool, United Kingdom
CONFERENCE DATE
  2017-12-04 to 2017-12-06
ISSN
  1751-1437
BOOK PUBLISHER
  SAGE Publications Inc.
ABSTRACT
  Introduction: In October 2010 the long-term ventilation service in Liverpool 
began providing support for non-spinal cord injury patients ventilated via a 
tracheostomy. As part of the Ventilation Centre (VIC) building work it 
became possible to look after stable tracheostomy ventilated patients away 
from ICU. A service has been established to assess, transfer and offer 
weaning for slow to wean patients from the North West and North Wales. 
Methods: Prospective data collection has been done by two of the authors, VF 
and RP for the first 5 years. Outcomes have been assessed regarding 
underlying reason for failure to wean, weaning success, and follow up to one 
year. Failure to wean has been classified as neuromuscular disease, COPD, 
obesity, kyphoscoliosis and chest wall deformity, post-surgery and other. 
This enables comparison with published UK data. Of the first 95 transfers 
for weaning it was noted that 10 had Guillain Barre Syndrome and this was 
the main reason for weaning failure. This is a group which may be 
traditionally felt to have a poor prognosis, and in whom the evidence is 
limited. Results: The median age for GBS patients was 58 years, and 50% were 
male. All were transferred from a General ICU, the median length of stay in 
the referring ICU prior to transfer was 69 days (range 16-265 days). The 
median VIC length of stay before discharge was 65.5 days (range 18-121 
days), including discharge planning. They were profoundly weak on admission, 
mean MRC sum score 22/60. Despite this all were weaned and decannulated, 
seven discharged with long-term nocturnal NIV, three with no support. All 
those with NIV were issued cough assist devices initially for home use. Two 
went directly home, and eight to rehabilitation. Nine were alive one year 
after VIC discharge and six were living in their own home. No patients had 
PEG feeding on discharge, all were orally fed. Whilst four patients were 
treated for pneumonia on the VIC, no patients required re-escalation of care 
to the General ICU. Conclusions: Patients with GBS as the reason for weaning 
failure had spent longer on the referring ICU, and then spent longer on the 
VIC compared with allcomers (median 69 vs 48 days and 65.5 vs 42 days 
respectively). Despite signifcant peripheral muscle weakness a weaning 
approach based around nocturnal NIV, chest physiotherapy and physical 
rehabilitation can produce good outcomes in selected patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; Guillain Barre syndrome; weaning; 
EMTREE MEDICAL INDEX TERMS
  adult; breathing exercise; case report; chronic obstructive lung disease; clinical article; conference abstract; feeding; female; follow up; hospital discharge; human; intensive care unit; kyphoscoliosis; length of stay; male; middle aged; muscle weakness; non continuous ventilator; obesity; pneumonia; prognosis; prospective study; rehabilitation; surgery; thorax deformity; treatment failure; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623280365
DOI
  10.1177/1751143718772957
FULL TEXT LINK
  http://dx.doi.org/10.1177/1751143718772957
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17511437&id=doi:10.1177%2F1751143718772957&atitle=Outcomes+for+patients+with+Guillain+Barre+Syndrome+transferred+to+a+new+weaning+and+long-term+ventilation+service+in+Liverpool%2C+UK&stitle=J.+Intensive+Care+Soc.&title=Journal+of+the+Intensive+Care+Society&volume=19&issue=2&spage=18&epage=&aulast=Parker&aufirst=Robert&auinit=R.&aufull=Parker+R.&coden=&isbn=&pages=18-&date=2018&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 95
TITLE
  Systematic review of respiratory approach to the quadriplegic patient in the 
acute stage. The role of the respiratory physiotherapist
AUTHOR NAMES
  Montigiani G.; Papi D.; Bucciardini L.; Sommariva M.
AUTHOR ADDRESSES
  (Montigiani G.; Papi D.; Bucciardini L.) AOU Careggi, Firenze, Italy.
(Sommariva M.) Ospedale Niguarda Ca' Granda, Milano, Italy.
CORRESPONDENCE ADDRESS
  G. Montigiani, AOU Careggi, Firenze, Italy.
FULL RECORD ENTRY DATE
  2018-06-14
SOURCE
  Italian Journal of Medicine (2018) 12:2 Supplement 1 (83). Date of 
Publication: 1 May 2018
VOLUME
  12
ISSUE
  2
FIRST PAGE
  83
DATE OF PUBLICATION
  1 May 2018
CONFERENCE NAME
  23. Congresso Nazionale della Societa Scientifica FADOI
CONFERENCE LOCATION
  Bologna, Italy
CONFERENCE DATE
  2018-05-12 to 2018-05-15
ISSN
  1877-9352
BOOK PUBLISHER
  Page Press Publications
ABSTRACT
  Introduction: Pulmonary complications in spinal cord injury are the most 
common cause of death in the acute phase. During the acute stage is usually 
managed with two different approaches: the invasive approach, by having the 
patient undergoing tracheotomy and invasive ventilation or the non-invasive 
approach, which involves prematurely extubating the patient, supporting him 
with non-invasive ventilation (NIV) and manual or mechanical cough 
assistance. Purpose: The aim of the study was to investigate among the 
recently published articles, which would be the choice of respiratory care 
to the patient with a complete cervical spinal cord injury in the acute 
phase. Methods: A systematic review was performed selecting articles where 
the number of tracheotomy and non-tracheotomy in patients with a complete 
cervical spinal injury. Results: 19 articles were selected. Six articles 
show a preference to the non-invasive approach with a percentage of 
non-tracheotomy patients less than 50%. 13 articles have a percentage of 
tracheotomies greater than 50%. No study offers a randomized clinical trial 
in which the two interventions are compared. Discussion: It is preferable to 
carry out an early tracheotomy, considering it to be a faster and safer 
approach. Non-invasive ventilation prevents the infections and to short and 
long-term complications related to the presence of a tracheal cannula. 
Conclusions: NIV is therefore a valid alternative to invasive ventilation in 
the spinal cord injured patient but it requires a well-trained team where 
the respiratory physiotherapist plays a fundamental role.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  physiotherapist; 
EMTREE MEDICAL INDEX TERMS
  adult; cannula; cervical spinal cord injury; complication; conference abstract; female; human; infection; male; noninvasive ventilation; randomized controlled trial (topic); respiratory care; systematic review; trachea; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622517629
DOI
  10.4081/itjm.2018.s2
FULL TEXT LINK
  http://dx.doi.org/10.4081/itjm.2018.s2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18779352&id=doi:10.4081%2Fitjm.2018.s2&atitle=Systematic+review+of+respiratory+approach+to+the+quadriplegic+patient+in+the+acute+stage.+The+role+of+the+respiratory+physiotherapist&stitle=Ital.+J.+Med.&title=Italian+Journal+of+Medicine&volume=12&issue=2&spage=83&epage=&aulast=Montigiani&aufirst=G.&auinit=G.&aufull=Montigiani+G.&coden=&isbn=&pages=83-&date=2018&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 96
TITLE
  Surgical treatment for old subaxial cervical dislocation with bilateral 
locked facets in a 3-year-old girl
AUTHOR NAMES
  Li C.; Li L.; Duan J.; Zhang L.; Liu Z.
AUTHOR ADDRESSES
  (Li C.; Li L., 18940258679@163.com; Duan J.; Zhang L.; Liu Z.) Department of 
Orthopaedic Surgery, Shengjing Hospital, China Medical University, Shenyang 
City, Liaoning Province, China.
CORRESPONDENCE ADDRESS
  L. Li, Department of Orthopaedic Surgery, Shengjing Hospital, China Medical 
University, Shenyang City, Liaoning Province, China. Email: 
18940258679@163.com
AiP/IP ENTRY DATE
  2018-06-19
FULL RECORD ENTRY DATE
  2018-06-21
SOURCE
  Medicine (United States) (2018) 97:18 Article Number: e0553. Date of 
Publication: 1 May 2018
VOLUME
  97
ISSUE
  18
DATE OF PUBLICATION
  1 May 2018
ISSN
  1536-5964 (electronic)
  0025-7974
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Rationale: This study aimed to describe the case of a 3-year-old girl with 
old bilateral facet dislocation on cervical vertebrae 6 and 7, who had 
spinal cord transection, received surgical treatment, and achieved a 
relative satisfactory therapeutic effect. Patient concerns: A 3-year-old 
girl was urgently transferred to the hospital after a car accident. 
Diagnoses: she was diagnosed with splenic rupture, intracranial hemorrhage, 
cervical dislocation, spinal transection, and Monteggia fracture of the left 
upper limb. Interventions: The girl underwent emergency splenectomy and was 
transferred to the intensive care unit of the hospital 15 days later. 
One-stage anterior-posterior approach surgery (anterior discectomy, 
posterior laminectomy, and pedicle screw fixation) was performed when the 
patient stabilized after 45-day symptomatic treatment. The operation was 
uneventful. Outcomes: The reduction of lower cervical dislocation was 
satisfactory, with sufficient spinal cord decompression. The internal 
fixation position was good, and the spinal sequence was well restored. The 
girl was discharged 2 weeks later after the operation and followed up for 2 
years. The major nerve function of both upper limbs was recovered, with no 
obvious retardation of the growth of immature spine. Lessons: A satisfactory 
therapeutic effect was achieved for a pediatric old subaxial cervical 
dislocation with bilateral locked facets using anterior discectomy, 
posterior laminectomy, and pedicle screw fixation. The posterior pedicle 
screw fixation provided a good three-dimensional stability of the spine, 
with reduced risk and complications caused by anterior internal fixation. 
The growth of immature spine was not obviously affected during the 2-year 
follow-up.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bilateral locked facet; cervical spine dislocation (surgery); old subaxial cervical dislocation (surgery); spine injury; 
EMTREE MEDICAL INDEX TERMS
  article; assisted ventilation; brain hemorrhage; case report; child; clinical article; coma; computer assisted tomography; digital radiography; discectomy; emergency surgery; female; follow up; Glasgow coma scale; hospital discharge; human; laminectomy; monteggia fracture; nerve function; nuclear magnetic resonance imaging; palliative therapy; patient satisfaction; pediatric intensive care unit; pedicle screw; physical examination; preschool child; priority journal; rib fracture; spinal cord decompression; spinal cord transsection; spleen rupture; splenectomy; tracheotomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180418114
MEDLINE PMID
  29718848 (http://www.ncbi.nlm.nih.gov/pubmed/29718848)
PUI
  L622559925
DOI
  10.1097/MD.0000000000010553
FULL TEXT LINK
  http://dx.doi.org/10.1097/MD.0000000000010553
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15365964&id=doi:10.1097%2FMD.0000000000010553&atitle=Surgical+treatment+for+old+subaxial+cervical+dislocation+with+bilateral+locked+facets+in+a+3-year-old+girl&stitle=Medicine&title=Medicine+%28United+States%29&volume=97&issue=18&spage=&epage=&aulast=Li&aufirst=Cheng&auinit=C.&aufull=Li+C.&coden=MEDIA&isbn=&pages=-&date=2018&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 97
TITLE
  Adult-onset neurocutaneous melanosis with Dandy-Walker malformation
AUTHOR NAMES
  Chang T.-W.; Hsieh P.-C.; Liu Z.-H.; Tu P.-H.
AUTHOR ADDRESSES
  (Chang T.-W.; Hsieh P.-C.; Liu Z.-H.; Tu P.-H., d12096@cloud.cgmh.org.tw) 
Department of Neurosurgery, Chang Gung University, Chang Gung Memorial 
Hospital, 5, FuShing Street, Kweishan, Taoyuan, Taiwan.
CORRESPONDENCE ADDRESS
  P.-H. Tu, Department of Neurosurgery, Chang Gung University, Chang Gung 
Memorial Hospital, 5, FuShing Street, Kweishan, Taoyuan, Taiwan. Email: 
d12096@cloud.cgmh.org.tw
AiP/IP ENTRY DATE
  2018-07-10
FULL RECORD ENTRY DATE
  2018-07-12
SOURCE
  Formosan Journal of Surgery (2018) 51:3 (118-121). Date of Publication: 1 
May 2018
VOLUME
  51
ISSUE
  3
FIRST PAGE
  118
LAST PAGE
  121
DATE OF PUBLICATION
  1 May 2018
ISSN
  2213-5413 (electronic)
  1682-606X
BOOK PUBLISHER
  Wolters Kluwer Medknow Publications, B9, Kanara Business Centre, off Link 
Road, Ghatkopar (E), Mumbai, India.
ABSTRACT
  Neurocutaneous melanosis (NCM) is characterized by diffuse or focal 
proliferation of melanin-producing cells over the skin or leptomeninges. 
Even without malignant transformation, the prognosis is poor after 
symptomatic progression of NCM, resulting from either mass effect in central 
nervous system or hydrocephalus. We reported a 26-year-old female patient 
with rapid deterioration after the onset of NCM. Despite no solid tumor 
formation, elevated cerebrospinal fluid protein content, which complicated 
shunting procedure, associated with hydrocephalus played the key role in 
clinical deterioration. Adult onset of NCM with Dandy-Walker malformation 
was never reported in our literature review. Diagnosis and treatment for 
such disease entity are discussed.
EMTREE DRUG INDEX TERMS
  glycerol (drug therapy); melanin (endogenous compound); protein (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult onset neurocutaneous melanosis (diagnosis); Dandy Walker syndrome (diagnosis); melanosis (diagnosis); phakomatosis (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; article; behavior disorder; bizarre behavior; brain angiography; brain cyst; brain fourth ventricle; brain hemorrhage; brain tissue; brain tomography; brain ventricle peritoneum shunt; case report; cerebellum hypoplasia; cerebrospinal fluid analysis; cerebrospinal fluid drainage system (adverse device effect); clinical article; computer assisted tomography; consciousness; contrast enhancement; craniotomy; dermis; dizziness; drowsiness; emergent cystoperitoneal shunt; facial nerve paralysis; female; headache; hospital admission; hospital discharge; human; hydrocephalus (surgery); incoherent speech; limb; lumbar puncture; mechanical ventilator; medical history; melanoma (diagnosis); nausea and vomiting; neuroimaging; neurologic examination; nevus; nuclear magnetic resonance imaging; perivascular space; physical examination; pigmented nevus (drug therapy); posterior fossa; postoperative period; priority journal; protein cerebrospinal fluid level; radiodiagnosis; respiratory function; scar; septic shock; shunt failure (complication); skin biopsy; speech disorder; spinal cord compression; spine radiography; spine tumor; syringomyelia; tonic clonic seizure; tracheostomy; trunk; unsteady gait; 
CAS REGISTRY NUMBERS
  glycerol (56-81-5)
  melanin (8049-97-6)
  protein (67254-75-5)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Radiology (14)
  Drug Literature Index (37)
  Epilepsy Abstracts (50)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180471663
PUI
  L622901269
DOI
  10.4103/fjs.fjs_108_17
FULL TEXT LINK
  http://dx.doi.org/10.4103/fjs.fjs_108_17
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22135413&id=doi:10.4103%2Ffjs.fjs_108_17&atitle=Adult-onset+neurocutaneous+melanosis+with+Dandy-Walker+malformation&stitle=Formosan+J.+Surg.&title=Formosan+Journal+of+Surgery&volume=51&issue=3&spage=118&epage=121&aulast=Chang&aufirst=Ting-Wei&auinit=T.-W.&aufull=Chang+T.-W.&coden=&isbn=&pages=118-121&date=2018&auinit1=T&auinitm=-W
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 98
TITLE
  Persistent Extreme Hyperextension of the Fetal Neck: Clinical and 
Neuroimaging Findings
AUTHOR NAMES
  Shrot S.; Johnson C.T.; Golden W.C.; Baschat A.A.; Bullard J.E.; Tekes A.; Poretti A.; Dunn E.; Huisman T.A.G.M.
AUTHOR ADDRESSES
  (Shrot S.; Tekes A.; Poretti A.; Dunn E.; Huisman T.A.G.M., 
thuisma1@jhmi.edu) Section of Pediatric Neuroradiology, Division of 
Pediatric Radiology and Pediatric Neuroradiology, Department of Radiology 
and Radiological Science, Johns Hopkins Hospital, Baltimore, United States.
(Shrot S.) Department of Diagnostic Imaging, Sheba Medical Center, 
Ramat-Gan, Israel.
(Johnson C.T.) Department of Gynecology & Obstetrics, Johns Hopkins 
University School of Medicine, Baltimore, United States.
(Golden W.C.; Bullard J.E.) Division of Neonatology, Department of 
Pediatrics, Johns Hopkins University School of Medicine, Baltimore, United 
States.
(Baschat A.A.) Center for Fetal Therapy, Department of Obstetrics, 
Gynecology, and Reproductive Sciences, Johns Hopkins University School of 
Medicine, Baltimore, United States.
(Poretti A.) Department of Neurogenetics, Kennedy Krieger Institute, 
Baltimore, United States.
CORRESPONDENCE ADDRESS
  T.A.G.M. Huisman, Section of Pediatric Neuroradiology, Division of Pediatric 
Radiology and Pediatric Neuroradiology, Department of Radiology and 
Radiological Science, Johns Hopkins Hospital, Baltimore, United States. 
Email: thuisma1@jhmi.edu
AiP/IP ENTRY DATE
  2018-02-09
FULL RECORD ENTRY DATE
  2018-05-11
SOURCE
  Journal of Neuroimaging (2018) 28:3 (278-282). Date of Publication: 1 May 
2018
VOLUME
  28
ISSUE
  3
FIRST PAGE
  278
LAST PAGE
  282
DATE OF PUBLICATION
  1 May 2018
ISSN
  1552-6569 (electronic)
  1051-2284
BOOK PUBLISHER
  Blackwell Publishing Inc., subscrip@blackwellpub.com
ABSTRACT
  BACKGROUND AND PURPOSE: Persistent hyperextension of the fetal 
craniocervical junction or neck is one of several fetal positions commonly 
observed on prenatal imaging. Underlying fetal structural etiologies such as 
fetal neck masses and iniencephaly can be detected as causes of 
hyperextension. Caesarean delivery is considered in cases of vaginal 
delivery or obstructed labor for fear of cervical spinal cord injury. In 
this case series, we describe the prenatal magnetic resonance imaging (MRI) 
findings and their potential role in obstetric management and discuss 
postnatal outcomes in fetuses demonstrating prenatal imaging findings of 
persistent extreme hyperextension of the neck. METHODS: A retrospective 
cohort of fetuses with extreme fetal neck hyperextension on prenatal 
ultrasound and subsequent MRI is described. RESULTS: Persistent extreme neck 
hyperextension was demonstrated in four pregnancies. One patient showed 
resolution of head positioning prior to labor. In the other 3 patients, neck 
hyperextension persisted until labor. In these three pregnancies, caesarean 
section with early intubation was performed due to concern for airway 
compromise and cervical cord injury. An underlying structural neck 
abnormality with airway compromise was noted only in 1 patient (large 
venolymphatic malformation). No airway compromise, cervical spine, or spinal 
cord anomaly was identified in the remaining 3 patients. Noncervical fetal 
anomalies were detected only in 1 patient (arthogryposis multiplex and 
clubfoot deformities). In patients with no structural neck abnormality, 
early extubation was performed shortly following labor. CONCLUSIONS: 
Detailed, high-resolution fetal MRI may serve as a valuable secondary 
imaging modality for clinical decision making regarding management of 
pregnancy, in utero therapy, mode of delivery, and postnatal care.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neuroimaging; whiplash injury; 
EMTREE MEDICAL INDEX TERMS
  article; breech presentation; case report; cervical spinal cord injury; cesarean section; clinical article; clubfoot; cohort analysis; disease severity; female; fetus; fetus echography; fetus malformation; human; hydramnios; intrapartum care; intrauterine growth retardation; intubation; lymphatic malformation; muscle hypotonia; nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; retrospective study; sleep disordered breathing; tracheostomy; vaginal delivery; 
DEVICE MANUFACTURERS
   (Germany)Siemens
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180076576
PUI
  L620552216
DOI
  10.1111/jon.12499
FULL TEXT LINK
  http://dx.doi.org/10.1111/jon.12499
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526569&id=doi:10.1111%2Fjon.12499&atitle=Persistent+Extreme+Hyperextension+of+the+Fetal+Neck%3A+Clinical+and+Neuroimaging+Findings&stitle=J.+Neuroimaging&title=Journal+of+Neuroimaging&volume=28&issue=3&spage=278&epage=282&aulast=Shrot&aufirst=Shai&auinit=S.&aufull=Shrot+S.&coden=JNERE&isbn=&pages=278-282&date=2018&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 99
TITLE
  Clinical outcomes and rates of aortic growth and reoperation after 1-stage 
repair of extensive chronic thoracic aortic dissection
AUTHOR NAMES
  Kouchoukos N.T.; Kulik A.; Castner C.F.
AUTHOR ADDRESSES
  (Kouchoukos N.T., ntkouch@aol.com; Castner C.F.) Division of Cardiovascular 
and Thoracic Surgery, Missouri Baptist Medical Center, BJC Healthcare, St 
Louis, United States.
(Kulik A.) Division of Cardiothoracic Surgery, Lynn Heart and Vascular 
Institute, Boca Raton Regional Hospital, Charles E. Schmidt College of 
Medicine, Florida Atlantic University, Boca Raton, United States.
CORRESPONDENCE ADDRESS
  N.T. Kouchoukos, Missouri Baptist Medical Center, 3009 N. Ballas Rd, Suite 
360C, St Louis, United States. Email: ntkouch@aol.com
AiP/IP ENTRY DATE
  2018-02-27
FULL RECORD ENTRY DATE
  2018-04-18
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2018) 155:5 (1926-1935). 
Date of Publication: 1 May 2018
VOLUME
  155
ISSUE
  5
FIRST PAGE
  1926
LAST PAGE
  1935
DATE OF PUBLICATION
  1 May 2018
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Objective: The study objective was to analyze clinical outcomes, distal 
segmental aortic growth, and aortic reoperation rates after 1-stage open 
repair of extensive chronic thoracic aortic dissection via bilateral 
anterior thoracotomy. Methods: Eighty patients underwent extensive 1-stage 
repair of chronic aortic dissection that included the ascending aorta, the 
entire aortic arch, and the varying lengths of the descending thoracic 
aorta. One half or more of the descending thoracic aorta was replaced in 62 
(78%) of the 80 patients. Hospital mortality was 2.5% (2 patients). Stroke 
occurred in 1 patient (1.2%), spinal cord ischemic injury occurred in 1 
patient (1.2%), and renal failure requiring long-term dialysis occurred in 2 
patients (2.5%). Sixty-five of the 78 hospital survivors (83%) had serial 
imaging studies suitable for calculation of growth rates of the remaining 
dissected thoracic and abdominal aorta. Forty-seven patients were followed 
for more than 5 years, and 21 patients were followed for more than 10 years. 
Results: The mean annual growth rate for the distal contiguous aorta was 1.7 
mm/y. Forty aortas increased in diameter, 16 aortas remained unchanged, and 
9 aortas decreased in diameter. Five patients required reoperation on the 
contiguous thoracic or abdominal aorta 8, 27, 34, 51, and 174 months 
postoperatively for progressive enlargement. Actuarial freedom from 
reoperation on the contiguous aorta at 5 and 10 years was 95.4% and 93%, 
respectively. Actuarial freedom from any aortic reoperation at 5 and 10 
years was 89.2% and 84.4%, respectively. Actuarial survival for the entire 
cohort at 5 and 10 years was 76.4% and 52.6%, respectively, and survival 
free of any aortic operation was 68.6% and 43.9%, respectively. No patient 
whose cause of death was known died of aortic rupture. Conclusions: Our 
extended experience with the 1-stage open procedure confirms its safety and 
durability for treatment of chronic aortic dissection with enlargement 
confined to the thoracic aorta. The procedure is associated with low 
operative risk and a low incidence of reoperation on the contiguous aorta. 
It represents a suitable alternative to the 2-stage, frozen elephant trunk, 
and hybrid procedures that are also used to treat this condition.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (diagnosis, surgery); aortic growth; cardiovascular parameters; chronic disease (diagnosis, surgery); clinical outcome; open surgery; reoperation; thoracic aortic dissection (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal aorta; adult; aortic arch; aortic regurgitation (surgery); article; ascending aorta; brain perfusion; cerebrovascular accident; computer assisted tomography; coronary artery bypass graft; disease severity; Ehlers Danlos syndrome (surgery); false aneurysm (surgery); female; follow up; heart failure; hospital mortality; human; iliac artery aneurysm (surgery); infrarenal abdominal aneurysm (surgery); kidney failure; Loeys Dietz syndrome (surgery); long term care; magnetic resonance angiography; major clinical study; male; nerve injury; neurologic disease; paraplegia; postoperative complication; priority journal; recurrent laryngeal nerve; surgical technique; thoracic aorta; tracheostomy; wound infection; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180125601
PUI
  L620785523
DOI
  10.1016/j.jtcvs.2017.10.158
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2017.10.158
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2017.10.158&atitle=Clinical+outcomes+and+rates+of+aortic+growth+and+reoperation+after+1-stage+repair+of+extensive+chronic+thoracic+aortic+dissection&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=155&issue=5&spage=1926&epage=1935&aulast=Kouchoukos&aufirst=Nicholas+T.&auinit=N.T.&aufull=Kouchoukos+N.T.&coden=JTCSA&isbn=&pages=1926-1935&date=2018&auinit1=N&auinitm=T
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 100
TITLE
  Surgery for extensive, chronic aortic dissection: What about the elephant 
(trunks) in the room?
AUTHOR NAMES
  Girardi L.N.
AUTHOR ADDRESSES
  (Girardi L.N., lngirard@med.cornell.edu) Department of Cardiothoracic 
Surgery, Weill Cornell Medicine, New York, United States.
CORRESPONDENCE ADDRESS
  L.N. Girardi, Department of Cardiothoracic Surgery, Weill Cornell Medicine, 
525 E 68th St, M-404, New York, United States. Email: 
lngirard@med.cornell.edu
AiP/IP ENTRY DATE
  2018-01-16
FULL RECORD ENTRY DATE
  2018-04-18
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2018) 155:5 (1923-1924). 
Date of Publication: 1 May 2018
VOLUME
  155
ISSUE
  5
FIRST PAGE
  1923
LAST PAGE
  1924
DATE OF PUBLICATION
  1 May 2018
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); frozen elephant trunk technique; surgical technique; 
EMTREE MEDICAL INDEX TERMS
  blood transfusion; cerebrovascular accident; deep hypothermic circulatory arrest; editorial; hemostasis; human; length of stay; morbidity; priority journal; spinal cord injury; sternotomy; thoracic aortic surgery; thoracotomy; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180026996
PUI
  L620196603
DOI
  10.1016/j.jtcvs.2017.12.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2017.12.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2017.12.003&atitle=Surgery+for+extensive%2C+chronic+aortic+dissection%3A+What+about+the+elephant+%28trunks%29+in+the+room%3F&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=155&issue=5&spage=1923&epage=1924&aulast=Girardi&aufirst=Leonard+N.&auinit=L.N.&aufull=Girardi+L.N.&coden=JTCSA&isbn=&pages=1923-1924&date=2018&auinit1=L&auinitm=N
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 101
TITLE
  Variety is the spice of life: One-stage or two-stage repair of extensive 
chronic thoracic aortic dissection
AUTHOR NAMES
  Preventza O.; Orozco-Sevilla V.; Pollock G.; Coselli J.S.
AUTHOR ADDRESSES
  (Preventza O., opsmile01@aol.com; Coselli J.S.) Department of Cardiovascular 
Surgery, Texas Heart Institute, Houston, United States.
(Preventza O., opsmile01@aol.com; Coselli J.S.) Department of Cardiovascular 
Surgery, CHI–Baylor St Luke's Medical Center, Houston, United States.
(Preventza O., opsmile01@aol.com; Orozco-Sevilla V.; Pollock G.; Coselli 
J.S.) Division of Cardiothoracic Surgery, Michael E. DeBakey Department of 
Surgery, Baylor College of Medicine, Houston, United States.
CORRESPONDENCE ADDRESS
  O. Preventza, One Baylor Plaza, BCM 390, Houston, United States. Email: 
opsmile01@aol.com
AiP/IP ENTRY DATE
  2018-01-19
FULL RECORD ENTRY DATE
  2018-04-18
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2018) 155:5 (1936-1937). 
Date of Publication: 1 May 2018
VOLUME
  155
ISSUE
  5
FIRST PAGE
  1936
LAST PAGE
  1937
DATE OF PUBLICATION
  1 May 2018
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); one stage repair; surgical technique; thoracic aortic surgery; two stage repair; 
EMTREE MEDICAL INDEX TERMS
  aortic reconstruction; aortic rupture; cerebrovascular accident; chronic obstructive lung disease; connective tissue disease; editorial; hospital mortality; human; incision; intermethod comparison; lung function; mechanical ventilator; priority journal; reoperation; spinal cord injury; sternotomy; thoracoabdominal aorta aneurysm; thoracotomy; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180030309
PUI
  L620208610
DOI
  10.1016/j.jtcvs.2017.12.033
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2017.12.033
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2017.12.033&atitle=Variety+is+the+spice+of+life%3A+One-stage+or+two-stage+repair+of+extensive+chronic+thoracic+aortic+dissection&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=155&issue=5&spage=1936&epage=1937&aulast=Preventza&aufirst=Ourania&auinit=O.&aufull=Preventza+O.&coden=JTCSA&isbn=&pages=1936-1937&date=2018&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 102
TITLE
  Predictors of failure of decannulation of tracheostomy: A retrospective and 
observational data analysis from a tertiary care teaching hospital
AUTHOR NAMES
  Gupta A.; Garg A.; Dutt C.
AUTHOR ADDRESSES
  (Gupta A.) Medanta-The Medicity, Gurugram, Haryana, India.
(Garg A.) Institute of Neurosciences, Medanta-The Medicity, Gurugram, 
Haryana, India.
(Dutt C.) Institute of Critical Care and Anesthesia, Medanta-The Medicity, 
Gurugram, Haryana, India.
CORRESPONDENCE ADDRESS
  A. Gupta, Medanta-The Medicity, Gurugram, Haryana, India.
FULL RECORD ENTRY DATE
  2018-07-03
SOURCE
  Neurorehabilitation and Neural Repair (2018) 32:4-5 (504). Date of 
Publication: 1 Apr 2018
VOLUME
  32
ISSUE
  4-5
FIRST PAGE
  504
DATE OF PUBLICATION
  1 Apr 2018
CONFERENCE NAME
  10th World Congress for NeuroRehabilitation, WCNR 2018
CONFERENCE LOCATION
  Mumbai, India
CONFERENCE DATE
  2018-02-07 to 2018-02-10
ISSN
  1552-6844
BOOK PUBLISHER
  SAGE Publications Inc.
ABSTRACT
  Objectives: Airway protection is imperative in neurologically unstable 
patients and one of the most common surgical procedure performed in the 
intensive care units to provide mechanical ventilation and toileting of 
pulmonary secretions is Tracheostomy.1 “Decannulation” is defined as the 
process of removing the tracheostomy tube that facilitates the path of 
weaning from mechanical ventilation and results in spontaneous breathing. 
This vital transition is a simple and rapid process in most of the cases. 
However, this apparently simple step needs a coordinated effort of brain, 
swallowing, coughing and vocal cord muscles. There have been reported 
complications including death2 due to lack of evaluation and closure of 
stoma post tracheostomy tube removal. Despite the importance of such a 
bedside procedure, it is still unknown in most of the centers of the world 
when a tracheostomy tube can be safely removed. In this study, we aim to 
analyze the factors which affect failure of decannulation in neurology and 
neurosurgery patients, thus helping us create a scoring system for a more 
objectified evaluation and preventing any complication(s) related to the 
procedure. Methods: We retrospectively reviewed all the inpatients with 
neurological and neurosurgical conditions who failed in the process of 
decannulation during the period of August 2016 to July 2017. We extracted 
data from our electronic health records including patient characteristics, 
level of consciousness of patients, indications of tracheostomy, associated 
co-morbidities and success or failure of swallowing assessment 
pre-decannulation. Results: The 26 patients (n) who failed decannulation 
procedure in the given period were majority from Neurology conditions 
(n=21). There were 22 males (84%) and 4 females (16%), with a mean age of 62 
Years and a mean weight of 71 kg who failed decannulation. The most common 
indication of tracheostomy in these patients was cerebro-vascular accident 
(n=16, 61%), brain malignancy (n=3, 11%), traumatic brain injury (n=3, 11%), 
motor neuron disease (n=2, 7%) and spinal cord injury (n=2, 7%). Amongst the 
patients with stroke, there were 9 patients with infarct (n=34%) and 2 with 
hemorrhage (7%).There was a significant 2 relation between the level of 
consciousness and the result of removal of tracheostomy tube as low GCS 
patients (<8/15) were 12 in number (46%). It was also observed that 23 
patients (88.4%) failed in the swallowing assessment which was performed 
pre-decannulation procedure and most of these required some swallowing 
intervention to pass the test (n=20). There was a higher chance of 
decannulation failure in stroke patients (56%) with Right MCA infarct which 
can be explained by the control of swallow and speech centers by this 
cerebral territory. Difficult intubation (n=13, 50%) was not associated with 
decannulation failure. Presence of sepsis (34%) witnessed a higher rate of 
decannulation failure. Amongst other associated comorbidities were 
Hypertension (n=23, 88%), Diabetes (n=11, 42%), Seizure disorder (n=4, 15%) 
Smoking (n=10, 38%) and Bronchial Asthma (n=5, 19%) which accounted for 
higher chances of decannulation failure. Conclusions: Despite the importance 
and relevance of the procedure of decannulation, there are subjective and 
variable algorithms3, multiple aberrations in the complex interplay of 
systems, dearth of literature and ambiguity in screening and evaluation of 
patients which limit our understanding in this unexplored area of 
neurosciences and intensive care. To better understand the practice of 
decannulation, we propose developing of a scoring system which can assess 
the patient objectively and prevent aspiration and failure of this process.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  data analysis; retrospective study; teaching hospital; tertiary health care; tracheostomy tube; 
EMTREE MEDICAL INDEX TERMS
  adult; aspiration; asthma; bleeding; brain cancer; cancer patient; cerebral artery disease; clinical article; clinical evaluation; comorbidity; complication; conference abstract; consciousness; controlled study; death; diabetes mellitus; electronic health record; epilepsy; female; human; hypertension; intensive care; intubation; male; middle aged; motor neuron disease; neurology; neurosurgery; prevention; scoring system; sepsis; smoking; speech; spinal cord injury; stoma; stroke patient; swallowing; traumatic brain injury; treatment failure; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622759745
DOI
  10.1177/1545968318765498
FULL TEXT LINK
  http://dx.doi.org/10.1177/1545968318765498
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526844&id=doi:10.1177%2F1545968318765498&atitle=Predictors+of+failure+of+decannulation+of+tracheostomy%3A+A+retrospective+and+observational+data+analysis+from+a+tertiary+care+teaching+hospital&stitle=Neurorehabil.+Neural+Repair&title=Neurorehabilitation+and+Neural+Repair&volume=32&issue=4-5&spage=504&epage=&aulast=Gupta&aufirst=Akanksha&auinit=A.&aufull=Gupta+A.&coden=&isbn=&pages=504-&date=2018&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 103
TITLE
  The natural history of dysphagia in ALS patients with bulbar and spinal 
onset
AUTHOR NAMES
  Manera U.; D'Ovidio F.; Calvo A.; Moglia C.; Cammarosano S.; Ilardi A.; Canosa A.; Bersano E.; Mazzini L.; Chiò A.
AUTHOR ADDRESSES
  (Manera U.; D'Ovidio F.; Calvo A.; Moglia C.; Cammarosano S.; Ilardi A.; 
Canosa A.; Chiò A.) Rita Levi Montalcini Department of Neuroscience, 
University of Turin, Turin, Italy.
(Bersano E.; Mazzini L.) Azienda Ospedaliero Universitaria Maggiore della 
Carità, Novara, Novara, Italy.
CORRESPONDENCE ADDRESS
  U. Manera, Rita Levi Montalcini Department of Neuroscience, University of 
Turin, Turin, Italy.
FULL RECORD ENTRY DATE
  2018-05-30
SOURCE
  Neurology (2018) 90:15 Supplement 1. Date of Publication: 1 Apr 2018
VOLUME
  90
ISSUE
  15
DATE OF PUBLICATION
  1 Apr 2018
CONFERENCE NAME
  70th Annual Meeting of the American Academy of Neurology, AAN 2018
CONFERENCE LOCATION
  Los Angeles, Ca, United States
CONFERENCE DATE
  2018-04-21 to 2018-04-27
ISSN
  1526-632X
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Objective: To assess the progression rate of dysphagia (ALSFRS-R scale) in a 
population-based series of ALS patients. Background: Few studies 
investigated the interaction between dysphagia and site of onset, and none 
evaluated it in terms of progression rate. Design/Methods: We enrolled 871 
ALS patients (580 with spinal onset and 291 with bulbar onset), resident in 
Piemonte and Valle d'Aosta regions, Italy, diagnosed from January 1, 2007 to 
December 31, 2013. Dysphagia severity was classified in three categories, 
based on ALSFRS-R item 3: “normal” (item score 4), “moderate” (scores 3 and 
2), and “severe” (scores 1 and 0). The progression of dysphagia in ALS 
patients was treated as time-dependent variable, and was reassessed at each 
visit (Number of visits=6,845). Progression rate of dysphagia was calculated 
separately among patients with bulbar and spinal onset (N=642); for both 
categories, intervals ended with the date when dysphagia became severe 
(ALSFRS-R item 3 < 2); the starting date was represented by the date of 
symptom onset for bulbar patients (N=279) and by the date of first bulbar 
symptoms (considering ALSFRS-R item 1 and item 3 < 4) for spinal patients 
(N=363); 217 patients did not develop dysphagia during the follow-up. 
Results: ALS patients had moderate dysphagia after a median of 24.4 months 
(IQR=13.5-44.7) from date of first symptoms, which progressed to severe 
dysphagia after additional 17.7 months (IQR=9.5-29.8), and death or 
tracheostomy after additional 6.9 months (IQR=2.6-14.7). The progression 
rate of the disease showed a median time interval of 17.4 months 
(IQR=8.9-29.5) between the first bulbar symptom and severe dysphagia. These 
time intervals were significantly shorter in patients with spinal onset 
(median 11.9 months; IQR=5.5-24.1) than in patients with bulbar onset (22.9 
months; IQR=16.0- 31.8) (Wilcoxon test p=0.000). Conclusions: Progression 
rate of dysphagia from first symptoms to severe status differs significantly 
between ALS patients with bulbar and spinal onset.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia; history; 
EMTREE MEDICAL INDEX TERMS
  adult; Aosta Valley; conference abstract; controlled study; death; dependent variable; diagnosis; disease course; female; follow up; human; major clinical study; male; rank sum test; resident; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622309466
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1526632X&id=doi:&atitle=The+natural+history+of+dysphagia+in+ALS+patients+with+bulbar+and+spinal+onset&stitle=Neurology&title=Neurology&volume=90&issue=15&spage=&epage=&aulast=Manera&aufirst=Umberto&auinit=U.&aufull=Manera+U.&coden=&isbn=&pages=-&date=2018&auinit1=U&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 104
TITLE
  Spinal muscular atrophy type I and the dual role of viruses: An interview 
with professor basil T. Darras, Professor of neurology (pediatrics) at 
harvard medical school
AUTHOR NAMES
  Mammas I.N.; Spandidos D.A.
AUTHOR ADDRESSES
  (Mammas I.N.; Spandidos D.A., spandidos@spandidos.gr) Department of Clinical 
Virology, School of Medicine, University of Crete, Heraklion, Greece.
CORRESPONDENCE ADDRESS
  D.A. Spandidos, Department of Clinical Virology, School of Medicine, 
University of Crete, Heraklion, Greece. Email: spandidos@spandidos.gr
AiP/IP ENTRY DATE
  2018-03-14
FULL RECORD ENTRY DATE
  2018-03-19
SOURCE
  Experimental and Therapeutic Medicine (2018) 15:4 (3673-3679). Date of 
Publication: 1 Apr 2018
VOLUME
  15
ISSUE
  4
FIRST PAGE
  3673
LAST PAGE
  3679
DATE OF PUBLICATION
  1 Apr 2018
ISSN
  1792-1015 (electronic)
  1792-0981
BOOK PUBLISHER
  Spandidos Publications, 10 Vriaxidos Street, Athens, Greece. 
subscriptions@spandidos-publications.com
ABSTRACT
  According to Professor Basil T. Darras, Professor of Neurology (Pediatrics) 
at Harvard Medical School and Director of the Spinal Muscular Atrophy (SMA) 
Program at Boston Children's Hospital in Boston (MA, USA), the diagnosis of 
SMA type I is clinical and is based on detailed general physical and 
neurological examinations. SMA type I remains the most common genetic 
disease resulting in death in infancy and is really devastating for the 
child, the parents, as well as the medical professionals with the privilege 
of caring for patients with SMA and their parents. The proposed management 
options include: i) no respiratory support; ii) non-invasive ventilation; 
and iii) tracheotomy with mechanical ventilation. Deciding, which option is 
the best, is indeed a very personal decision. The optimal clinical care 
should be extremely mindful of parents' wishes and management goals with 
regard to the quality of life. Since the end of 2016 in the USA, and 
recently in Europe, there exists the possibility of accessing a novel 
treatment drug for SMA, namely Nusinersen. This antisense oligonucleotide is 
administered intrathecally and increases the production of the fully 
functional SMN protein, thus improving motor function, the quality of life 
and survival. Among the ongoing clinical trials, oral treatment with RG7916, 
a small molecule SMN2 splicing modifier, appears to be really promising. 
Gene therapy using viral vectors is expected to offer an ‘one and done’ 
therapy and possibly a cure, if administered early in life, before any 
symptoms appear. It is really interesting that viruses, which at the moment 
are the cause of death of children with SMA, if genetically modified, may be 
used for their treatment.
EMTREE DRUG INDEX TERMS
  nusinersen (drug therapy); risdiplam; survival motor neuron protein (endogenous compound); virus vector; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Werdnig Hoffmann disease (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; clinical trial (topic); gene therapy; genetic screening; human; motor performance; pediatrics; quality of life; survival; tracheotomy; 
DRUG TRADE NAMES
  rg 7916
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Human Genetics (22)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180171740
PUI
  L621154560
DOI
  10.3892/etm.2018.5884
FULL TEXT LINK
  http://dx.doi.org/10.3892/etm.2018.5884
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17921015&id=doi:10.3892%2Fetm.2018.5884&atitle=Spinal+muscular+atrophy+type+I+and+the+dual+role+of+viruses%3A+An+interview+with+professor+basil+T.+Darras%2C+Professor+of+neurology+%28pediatrics%29+at+harvard+medical+school&stitle=Exp.+Ther.+Med.&title=Experimental+and+Therapeutic+Medicine&volume=15&issue=4&spage=3673&epage=3679&aulast=Mammas&aufirst=Ioannis+N.&auinit=I.N.&aufull=Mammas+I.N.&coden=&isbn=&pages=3673-3679&date=2018&auinit1=I&auinitm=N
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 105
TITLE
  Understanding demographic variables of neurological patients admitted to an 
Indian post hospital inpatient rehabilitation center: Exploring the 
essential needs
AUTHOR NAMES
  Janagama V.; Sagi P.; Kandiraju S.; Addanki S.
AUTHOR ADDRESSES
  (Janagama V.; Sagi P.; Kandiraju S.; Addanki S.) Suvitas Holistic Health 
Care Pvt Ltd, Hyderabad, Telangana, India.
CORRESPONDENCE ADDRESS
  V. Janagama, Suvitas Holistic Health Care Pvt Ltd, Hyderabad, Telangana, 
India.
FULL RECORD ENTRY DATE
  2018-07-03
SOURCE
  Neurorehabilitation and Neural Repair (2018) 32:4-5 (524). Date of 
Publication: 1 Apr 2018
VOLUME
  32
ISSUE
  4-5
FIRST PAGE
  524
DATE OF PUBLICATION
  1 Apr 2018
CONFERENCE NAME
  10th World Congress for NeuroRehabilitation, WCNR 2018
CONFERENCE LOCATION
  Mumbai, India
CONFERENCE DATE
  2018-02-07 to 2018-02-10
ISSN
  1552-6844
BOOK PUBLISHER
  SAGE Publications Inc.
ABSTRACT
  Objectives: To evaluate demographic data of neurological patients admitted 
to an Indian post hospital inpatient rehabilitation unit. Methods: We have 
analyzed data of 174 patients admitted to our inpatient rehabilitation 
center in Hyderabad, India. The data was collected between the period of 
July 2015 to March 2017 (20 Months). Results: The mean age of patients was 
51.96 (SD= 17.11). Out of the 174 patients 74.1% were males and 25.9% were 
females. 25.9% of patients were retired while 43.7% were employed and 9.2% 
were students. 93.1% were directly admitted from hospital where as 6.9% came 
from home. 54.6% had stroke, 27.6% had Traumatic Brain Injury, 8.6% had 
Spinal cord injury, 4.6% had Polyneuropathies, 4.5% were others. Out of the 
174 patients, 70.1% of them had associated medical comorbid conditions like 
hypertension (44.3%), type 2 diabetes Mellitus (40.8%), coronary artery 
disease (2.3%), hyperlipidemia (1.1%), atrial fibrillation (1.1%), 
overweight (1.7%), alcohol (10.3%), Tobacco (8%) and others (12.1%). On 
admission, more than half (54%) of patients needed artificial feeding, more 
than onefourth (29.9%) had tracheostomy and a significant number of patients 
(77%) had urinary catheter. Conclusions: With increasing incidence of 
neurological patients in India, there is a dire need to understand 
demographic variables and develop cost effective resources and protocols to 
improve rehabilitation outcomes. Majority of the effected individuals were 
still working (43.7%) or were students (9.2%) which can cause significant 
burden of number of disability adjusted life years. Hence it is very crucial 
for stake holders to develop multidisciplinary rehabilitation facilities for 
early, effective and empowered recovery of neurological patients.
EMTREE DRUG INDEX TERMS
  alcohol; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hospital patient; rehabilitation center; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial feeding; atrial fibrillation; cerebrovascular accident; conference abstract; controlled study; coronary artery disease; disability-adjusted life year; female; human; hyperlipidemia; hypertension; incidence; India; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; obesity; polyneuropathy; rehabilitation; remission; spinal cord injury; student; tobacco; tracheostomy; traumatic brain injury; urinary catheter; 
CAS REGISTRY NUMBERS
  alcohol (64-17-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622759809
DOI
  10.1177/1545968318765498
FULL TEXT LINK
  http://dx.doi.org/10.1177/1545968318765498
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526844&id=doi:10.1177%2F1545968318765498&atitle=Understanding+demographic+variables+of+neurological+patients+admitted+to+an+Indian+post+hospital+inpatient+rehabilitation+center%3A+Exploring+the+essential+needs&stitle=Neurorehabil.+Neural+Repair&title=Neurorehabilitation+and+Neural+Repair&volume=32&issue=4-5&spage=524&epage=&aulast=Janagama&aufirst=Vijay&auinit=V.&aufull=Janagama+V.&coden=&isbn=&pages=524-&date=2018&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 106
TITLE
  Use of pediatric Tracheal Stoma Retainer(®) in a 24-year-old spinal muscular 
atrophy patient
AUTHOR NAMES
  Ito H.; Sobue K.
AUTHOR ADDRESSES
  (Ito H., oniheizo1745@gmail.com; Sobue K.) Department of Anesthesiology and 
Intensive Care Medicine, Nagoya City University Graduate School of Medical 
Sciences, Mizuho, Japan.
CORRESPONDENCE ADDRESS
  H. Ito, Department of Anesthesiology and Intensive Care Medicine, Nagoya 
City University Graduate School of Medical Sciences, Mizuho, Japan. Email: 
oniheizo1745@gmail.com
AiP/IP ENTRY DATE
  2018-04-27
FULL RECORD ENTRY DATE
  2018-09-14
SOURCE
  Pediatrics International (2018) 60:4 (387-388). Date of Publication: 1 Apr 
2018
VOLUME
  60
ISSUE
  4
FIRST PAGE
  387
LAST PAGE
  388
DATE OF PUBLICATION
  1 Apr 2018
ISSN
  1442-200X (electronic)
  1328-8067
BOOK PUBLISHER
  Blackwell Publishing
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway creation device; phonation device; spinal muscular atrophy type 2; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; case report; clinical article; gastrostomy; hospital discharge; human; influenza B; male; motor retardation; note; One-way Valve; phonation; priority journal; respiratory distress; respiratory failure; Tracheal Stoma Retainer; tracheostomy; tracheostomy tube; ventilator weaning; verbal communication; young adult; 
DEVICE TRADE NAMES
  One-way Valve  Koken

  Tracheal Stoma Retainer  , JapanKoken

DEVICE MANUFACTURERS
  Koken
   (Japan)Koken
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180291431
MEDLINE PMID
  29508482 (http://www.ncbi.nlm.nih.gov/pubmed/29508482)
PUI
  L621787941
DOI
  10.1111/ped.13516
FULL TEXT LINK
  http://dx.doi.org/10.1111/ped.13516
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1442200X&id=doi:10.1111%2Fped.13516&atitle=Use+of+pediatric+Tracheal+Stoma+Retainer%C2%AE+in+a+24-year-old+spinal+muscular+atrophy+patient&stitle=Pediatr.+Int.&title=Pediatrics+International&volume=60&issue=4&spage=387&epage=388&aulast=Ito&aufirst=Hidekazu&auinit=H.&aufull=Ito+H.&coden=JAMMF&isbn=&pages=387-388&date=2018&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 107
TITLE
  Angiography Before Posterior Mediastinal Tumor Resection: Selection Criteria 
and Patient Outcomes
AUTHOR NAMES
  Madariaga M.L.; Borges L.F.; Rabinov J.D.; Chang D.C.; Lanuti M.; Mathisen D.J.; Gaissert H.A.
AUTHOR ADDRESSES
  (Madariaga M.L.; Lanuti M.; Mathisen D.J.; Gaissert H.A., 
hgaissert@partners.org) Division of Thoracic Surgery, Department of Surgery, 
Massachusetts General Surgery, Boston, United States.
(Borges L.F.) Department of Neurosurgery, Massachusetts General Surgery, 
Boston, United States.
(Rabinov J.D.) Department of Radiology, Massachusetts General Surgery, 
Boston, United States.
(Chang D.C.) Department of Surgery, Massachusetts General Surgery, Boston, 
United States.
CORRESPONDENCE ADDRESS
  H.A. Gaissert, Division of Thoracic Surgery, Department of Surgery, 
Massachusetts General Hospital, 55 Fruit St, Boston, United States. Email: 
hgaissert@partners.org
AiP/IP ENTRY DATE
  2018-03-06
FULL RECORD ENTRY DATE
  2018-04-03
SOURCE
  Annals of Thoracic Surgery (2018) 105:4 (1000-1007). Date of Publication: 1 
Apr 2018
VOLUME
  105
ISSUE
  4
FIRST PAGE
  1000
LAST PAGE
  1007
DATE OF PUBLICATION
  1 Apr 2018
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background: Resection of posterior mediastinal tumors may be complicated by 
bleeding or neurologic injury. Preoperative spinal angiography of 
mediastinal tumors has been underreported or not commonly practiced. This 
study evaluated the selection criteria and outcomes of patients with 
posterior mediastinal tumors who underwent preoperative angiography and 
embolization. Methods: This was a single-institution retrospective study of 
patients with posterior mediastinal tumors from 2002 to 2016. Multilevel 
spinal angiography was performed, with or without selective arterial 
embolization of vascular supply, in patients selected by thoracic or 
neurologic surgeons. Results: Ten of 87 patients (11%) with posterior 
mediastinal tumors underwent preoperative angiography. A mean of 11 arteries 
(range, 2 to 25) were studied. Embolization in 7 of 10 patients successfully 
occluded 1 to 3 arteries. There was no significant difference in age, sex, 
body mass index, American Society of Anesthesiologists Physical Status 
Classification, operative time, operative blood loss, complications, or 
death between patients with or without angiography. Patients who underwent 
angiography had larger tumors (1,490 vs 97 cm(3), p < 0.0001), involvement 
of the neuroforamen (44% vs 10%, p < 0.05), and a longer hospital stay (9 vs 
4.5 days, p < 0.05). Angiography was complicated in 1 patient by vocal cord 
ulceration after intubation of a tumor-compressed trachea. Shared blood 
supply between the tumor and the spinal cord precluded embolization and 
tumor resection in 1 patient. Use of angiography increased over time. 
Conclusions: Selective preoperative angiography for evaluation of posterior 
mediastinal tumors identifies arterial variations, threatened spinal 
arteries, and targets for embolization. The specific role of angiography and 
embolization requires further investigation to standardize indications and 
protocols for the number of arteries examined.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  clinical outcome; mediastinum tumor (surgery); posterior mediastinal tumor (surgery); spinal angiography; thorax surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; age; Anesthesiologists Physical Status Classification; arterial embolization; article; body mass; clinical assessment tool; clinical evaluation; controlled study; female; follow up; gender; Horner syndrome; hospitalization; human; intubation; length of stay; major clinical study; male; middle aged; mortality; neuroforamen; operation duration; operative blood loss; pneumonia; postoperative complication; preoperative evaluation; priority journal; prolonged air leak; retrospective study; spinal cord; trachea compression; tracheostomy; tumor volume; urinary tract infection; vascularization; vertebra; vocal cord disorder; vocal cord ulceration; wound infection; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cancer (16)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29373823 (http://www.ncbi.nlm.nih.gov/pubmed/29373823)
PUI
  L620929060
DOI
  10.1016/j.athoracsur.2017.12.028
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2017.12.028
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2017.12.028&atitle=Angiography+Before+Posterior+Mediastinal+Tumor+Resection%3A+Selection+Criteria+and+Patient+Outcomes&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=105&issue=4&spage=1000&epage=1007&aulast=Madariaga&aufirst=Maria+Lucia&auinit=M.L.&aufull=Madariaga+M.L.&coden=ATHSA&isbn=&pages=1000-1007&date=2018&auinit1=M&auinitm=L
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 108
TITLE
  Bridging the acute to chronic care gap
AUTHOR NAMES
  Iantomasi P.; Cagliostro M.
AUTHOR ADDRESSES
  (Iantomasi P., iantomasip@smh.ca; Cagliostro M., cagliostrom@smh.ca) St. 
Michael's Hospital, Toronto, Canada.
CORRESPONDENCE ADDRESS
  P. Iantomasi, St. Michael's Hospital, Toronto, Canada. Email: 
iantomasip@smh.ca
FULL RECORD ENTRY DATE
  2018-04-19
SOURCE
  Canadian Journal of Respiratory Therapy (2018) 54:1 (28). Date of 
Publication: 1 Mar 2018
VOLUME
  54
ISSUE
  1
FIRST PAGE
  28
DATE OF PUBLICATION
  1 Mar 2018
CONFERENCE NAME
  Canadian Society of Respiratory Therapists Annual Education Conference, CSRT 
2018
CONFERENCE LOCATION
  Vancouver, BC, Canada
CONFERENCE DATE
  2018-05-24 to 2018-05-26
ISSN
  2368-6820
BOOK PUBLISHER
  Canadian Society of Respiratory Therapists
ABSTRACT
  In our current health care climate, movement of patients from an acute care 
setting to a chronic care facility or rehabilitation centre is becoming 
increasingly challenging due to the limited number of beds and a high demand 
for these services. The waiting time for transfer can be lengthy, and 
therefore there are many patients ready to be transitioned, but who remain 
in an acute care hospital. This is especially true for those patients with 
specialized needs, such as patients with a tracheostomy or those with a 
spinal cord injury. Since these patients require particular care and have 
access to only a limited number of beds, in only a few specific centres, 
they are often waiting extended periods of time to access a placement. 
Having these patients remain in acute care hospitals while awaiting 
transition to another facility (chronic care or rehab), means that acute 
care providers are faced with unique challenges in terms of their management 
and clinical progress. At St. Michaels Hospital (SMH), an urban city 
teaching trauma hospital found in the heart of downtown Toronto, this 
situation is a frequent reality. As such, a respiratory therapist-led 
quality improvement project was developed in an effort to identify and 
implement strategies to minimize the gaps for these patients (tracheostomy 
and spinal cord injury) transitioning from acute to chronic care. Through 
the presentation of two case studies, the following will be discussed: the 
acute to chronic care gaps that were identified, the process changes that 
were implemented, the outcomes to date, the challenges faced with these 
initiatives, and areas for future improvement.
EMTREE MEDICAL INDEX TERMS
  adult; climate; conference abstract; emergency care; heart; human; rehabilitation; respiratory therapist; spinal cord injury; teaching; total quality management; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L621670100
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23686820&id=doi:&atitle=Bridging+the+acute+to+chronic+care+gap&stitle=Can.+J.+Resp.+Ther.&title=Canadian+Journal+of+Respiratory+Therapy&volume=54&issue=1&spage=28&epage=&aulast=Iantomasi&aufirst=P.&auinit=P.&aufull=Iantomasi+P.&coden=&isbn=&pages=28-&date=2018&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 109
TITLE
  Evolution of Simplified Frozen Elephant Trunk Repair for Acute DeBakey Type 
I Dissection: Midterm Outcomes
AUTHOR NAMES
  Roselli E.E.; Idrees J.J.; Bakaeen F.G.; Tong M.Z.; Soltesz E.G.; Mick S.; Johnston D.R.; Eagleton M.J.; Menon V.; Svensson L.G.
AUTHOR ADDRESSES
  (Roselli E.E., roselle@ccf.org; Idrees J.J.; Bakaeen F.G.; Tong M.Z.; 
Soltesz E.G.; Mick S.; Johnston D.R.; Svensson L.G.) Department of Thoracic 
and Cardiovascular Surgery, Aorta Center, Heart and Vascular Institute, 
Cleveland Clinic, Cleveland, United States.
(Eagleton M.J.) Department of Vascular Surgery, Aorta Center, Heart and 
Vascular Institute, Cleveland Clinic, Cleveland, United States.
(Menon V.) Department of Cardiovascular Medicine, Aorta Center, Heart and 
Vascular Institute, Cleveland Clinic, Cleveland, United States.
CORRESPONDENCE ADDRESS
  E.E. Roselli, Aorta Center, Cleveland Clinic, 9500 Euclid Ave/Desk J4-1, 
Cleveland, United States. Email: roselle@ccf.org
AiP/IP ENTRY DATE
  2017-12-11
FULL RECORD ENTRY DATE
  2018-02-28
SOURCE
  Annals of Thoracic Surgery (2018) 105:3 (749-755). Date of Publication: 1 
Mar 2018
VOLUME
  105
ISSUE
  3
FIRST PAGE
  749
LAST PAGE
  755
DATE OF PUBLICATION
  1 Mar 2018
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background: A modified technique for frozen elephant trunk (FET) repair of 
acute DeBakey type I dissection has evolved. Procedural modifications are 
described and midterm outcomes evaluated. Methods: From 2009 to 2016, 72 
patients with DeBakey type I dissection underwent emergency simplified FET. 
Mean age was 59 ± 15 years. Presentation included malperfusion (n = 22, 
31%), rupture (n = 12, 16%), and aortic insufficiency (n = 42, 58%). 
Concomitant procedures included valve replacement (n = 9), root replacement 
(n = 11; valve sparing n = 6), cusp repair (n = 11), and valve resuspension 
(n = 21). The first 39 were treated by modifying an early generation stent 
graft. The next 16 received newer modified stent grafts, and the latest 17 
underwent branched single anastomosis technique with left subclavian stent 
grafting. Results: Operative mortality was 4.2% (n = 3 of 72). Two presented 
comatose without recovering, the other died from coagulopathy complications. 
Morbidity included stroke (n = 3, 4.2%), spinal injury (n = 3, 4.2%; 1 
permanent), tracheostomy (n = 7, 9.7%), and renal failure (n = 2, 2.8%). 
Median follow-up was 28 ± 25 months. Survival was 92% at 6 months, 92% at 1 
year, 89% at 3 years, and 80% at 5 years. Among 69 survivors, follow-up 
imaging was available in 63 (91%). Of these, 58 (92%) patients thrombosed 
the treated false lumen, with shrinkage in 37(54%) patients from 42 ± 8 mm 
to 37 ± 7 mm. Ten patients underwent 14 late reinterventions for growth and 
incomplete thrombosis (7 endo extension, 4 left subclavian embolization, 1 
bypass, 2 false lumen embolization). Freedom from reintervention was 93% at 
6 months, 87% at 1 year, 77% at 3 years, and 72% at 5 years. Conclusions: 
Simplified FET for treating acute DeBakey type I dissection has evolved and 
remained safe. It promotes aortic remodeling, and simplifies management of 
chronic aortic complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute debakey type i dissection (surgery); aortic dissection (surgery); aortic surgery; clinical outcome; simplified frozen elephant trunk repair; 
EMTREE MEDICAL INDEX TERMS
  adult; aortic aneurysm endovascular graft; aortic regurgitation; aortic root surgery; aortic rupture; aortic valve repair; aortic valve replacement; aortic valve resuspension; arterial embolization; artery prosthesis; bleeding; blood clotting disorder; brain disease; brain hypoxia; brain injury; carotid artery injury; cerebrovascular accident; chest bleeding; comatose patient; conference paper; convalescence; coronary artery bypass graft; emergency surgery; endovascular aneurysm repair; female; follow up; hematoma; hemorrhagic shock; human; kidney failure; major clinical study; male; middle aged; morbidity; paralysis; paraplegia; polypropylene suture; priority journal; reoperation; retreatment; spinal cord injury; subclavian artery stent; surgical mortality; survival analysis; survival rate; survival time; survivor; thorax disease; tracheostomy; vertebral artery stenosis; visual impairment; 
DEVICE TRADE NAMES
  C-TAG  Gore

  Viabahn  , United StatesGore

DEVICE MANUFACTURERS
  Gore
   (United States)Gore
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29217087 (http://www.ncbi.nlm.nih.gov/pubmed/29217087)
PUI
  L619546557
DOI
  10.1016/j.athoracsur.2017.08.037
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2017.08.037
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2017.08.037&atitle=Evolution+of+Simplified+Frozen+Elephant+Trunk+Repair+for+Acute+DeBakey+Type+I+Dissection%3A+Midterm+Outcomes&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=105&issue=3&spage=749&epage=755&aulast=Roselli&aufirst=Eric+E.&auinit=E.E.&aufull=Roselli+E.E.&coden=ATHSA&isbn=&pages=749-755&date=2018&auinit1=E&auinitm=E
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 110
TITLE
  An unusual cause of recurrent laryngospasm: A case report
AUTHOR NAMES
  Cattermole G.N.; Ndebwanimana V.; Polzin-Rosenberg N.
AUTHOR ADDRESSES
  (Cattermole G.N., giles@cattermole.org.uk; Ndebwanimana V.; Polzin-Rosenberg 
N.) Emergency Department, Centre Hospitalier Universitaire de Kigali, 
University of Rwanda, Rwanda.
CORRESPONDENCE ADDRESS
  G.N. Cattermole, Emergency Department, Centre Hospitalier Universitaire de 
Kigali, University of Rwanda, Rwanda. Email: giles@cattermole.org.uk
AiP/IP ENTRY DATE
  2017-09-26
FULL RECORD ENTRY DATE
  2018-03-14
SOURCE
  African Journal of Emergency Medicine (2018) 8:1 (34-36). Date of 
Publication: 1 Mar 2018
VOLUME
  8
ISSUE
  1
FIRST PAGE
  34
LAST PAGE
  36
DATE OF PUBLICATION
  1 Mar 2018
ISSN
  2211-419X
BOOK PUBLISHER
  African Federation for Emergency Medicine, admin@afem.info
ABSTRACT
  Introduction: Laryngospasm is a partial or complete closure of the vocal 
cords, causing stridor and then complete airway obstruction. We present an 
unusual case of recurrent laryngospasm following cervical spine trauma. Case 
report: A 41-year-old pedestrian was hit by a car sustaining several spine 
fractures including a comminuted fracture of C1. These were initially 
unrecognised, and his cervical spine was not immobilised. During this time 
the patient experienced three episodes of laryngospasm requiring intubation. 
On day 11 his fractures were identified, and a Philadelphia collar was 
placed. He made a full recovery without any neurological sequelae. 
Discussion: Laryngospasm is a recognised complication of anaesthesia and 
intubation. This case illustrates that this life-threatening complication 
can also follow cervical fractures, and reinforces the need for prompt and 
careful review of imaging to identify such fractures in trauma patients, 
especially those with stridor.
EMTREE DRUG INDEX TERMS
  bronchodilating agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  larynx spasm (complication, diagnosis, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; bronchospasm (diagnosis, drug therapy); case report; cervical collar; cervical spine fracture (therapy); clavicle fracture; clinical article; clinical handover; comminuted fracture (therapy); computer assisted tomography; conservative treatment; convalescence; diagnostic error; echography; endotracheal intubation; extended focused assessment with sonography in trauma; extubation; Glasgow coma scale; hematothorax; hospital admission; hospital discharge; human; lung function; male; manubrium; multiple fracture (therapy); oxygen desaturation; oxygen saturation; pain assessment; patient transport; pelvis radiography; rib fracture; shoulder fracture; spine fracture (therapy); spinous process; stridor; tachycardia; tachypnea; thoracic spine; thorax radiography; tracheostomy; transverse process; vertebral canal; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170668630
PUI
  L618393480
DOI
  10.1016/j.afjem.2017.08.009
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.afjem.2017.08.009
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2211419X&id=doi:10.1016%2Fj.afjem.2017.08.009&atitle=An+unusual+cause+of+recurrent+laryngospasm%3A+A+case+report&stitle=Afr.+J.+Emerg.+Med.&title=African+Journal+of+Emergency+Medicine&volume=8&issue=1&spage=34&epage=36&aulast=Cattermole&aufirst=Giles+N.&auinit=G.N.&aufull=Cattermole+G.N.&coden=&isbn=&pages=34-36&date=2018&auinit1=G&auinitm=N
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 111
TITLE
  The impact of a specialized spinal cord injury center as compared with 
non-specialized centers on the acute respiratory management of patients with 
complete tetraplegia: An observational study
AUTHOR NAMES
  Richard-Denis A.; Feldman D.; Thompson C.; Albert M.; Mac-Thiong J.-M.
AUTHOR ADDRESSES
  (Richard-Denis A., andreane.rdenis@gmail.com; Thompson C.; Albert M.; 
Mac-Thiong J.-M.) Research Center, Hopital du Sacré-Cœur de Montréal, 
Montréal, Canada.
(Richard-Denis A., andreane.rdenis@gmail.com; Feldman D.; Albert M.; 
Mac-Thiong J.-M.) Faculty of Medicine, University of Montreal, Pavillon 7077 
Avenue du Parc, Montréal, Canada.
(Mac-Thiong J.-M.) CHU Ste-Justine, Montreal, Canada.
CORRESPONDENCE ADDRESS
  A. Richard-Denis, Research Center, Hopital du Sacré-Cœur de Montréal, 
Montréal, Canada. Email: andreane.rdenis@gmail.com
AiP/IP ENTRY DATE
  2017-11-20
FULL RECORD ENTRY DATE
  2018-09-18
SOURCE
  Spinal Cord (2018) 56:2 (142-150). Date of Publication: 1 Feb 2018
VOLUME
  56
ISSUE
  2
FIRST PAGE
  142
LAST PAGE
  150
DATE OF PUBLICATION
  1 Feb 2018
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study Design: Retrospective cohort study. Objectives: To compare the 
proportion of tracheostomy placement and duration of mechanical ventilation 
(MV) in patients with a complete cervical spinal cord injury (SCI) that were 
managed early or lately in a specialized acute SCI-center. The second 
objective was to determine the impact of the timing of admission to the 
SCI-center on the MV support duration. Setting: A single Level-1 trauma 
center specialized in SCI care in Quebec (Canada). Methods: A cohort of 81 
individuals with complete tetraplegia over a 6-years period was included. 
Group 1 (N = 57- early group-) was admitted before surgical management in 
one specialized acute SCI-center, whereas Group 2 (N = 24 -late group-) was 
surgically managed in a non-specialized center and transferred to the 
SCI-center for post-operative management only. The proportion of 
tracheostomy placement and MV duration were compared. Multivariate 
regression analysis was used to assess the impact of the timing of admission 
to the SCI-center on the MV duration during the SCI-center stay. Results: 
Patients in Group 2 had a higher proportion of tracheostomy (70.8 vs. 35.1%, 
p = 0.004) and a higher mean duration of MV support (68.0 ± 64.2 days vs. 
21.8 ± 29.7 days, p = 0.006) despite similar age, trauma severity (ISS), 
neurological level of injury and proportion of pneumonia. Later transfer to 
the specialized acute SCI-center was the main predictive factor of longer MV 
duration, with a strong impact factor (s = 946.7, p < 0.001). Conclusions: 
Early admission to a specialized acute SCI-center for surgical and 
peri-operative management after a complete tetraplegia is associated with 
lower occurrence of tracheostomy and shorter mechanical ventilation duration 
support. Sponsorship: MENTOR Program of the Canadian Institute of Health 
Research and US Department of Defense Spinal Cord Injury Research Program.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; complete cervical spinal cord injury; complete tetraplegia (surgery); health center; nonspecialized center; quadriplegia (surgery); specialized spinal cord injury center; spinal cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; cohort analysis; disease severity; emergency health service; female; hospital admission; human; major clinical study; male; pneumonia; priority journal; Quebec; retrospective study; spine surgery; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170802471
MEDLINE PMID
  29138486 (http://www.ncbi.nlm.nih.gov/pubmed/29138486)
PUI
  L619255946
DOI
  10.1038/s41393-017-0003-9
FULL TEXT LINK
  http://dx.doi.org/10.1038/s41393-017-0003-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fs41393-017-0003-9&atitle=The+impact+of+a+specialized+spinal+cord+injury+center+as+compared+with+non-specialized+centers+on+the+acute+respiratory+management+of+patients+with+complete+tetraplegia%3A+An+observational+study&stitle=Spinal+Cord&title=Spinal+Cord&volume=56&issue=2&spage=142&epage=150&aulast=Richard-Denis&aufirst=Andr%C3%A9ane&auinit=A.&aufull=Richard-Denis+A.&coden=SPCOF&isbn=&pages=142-150&date=2018&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 112
TITLE
  Fusion, Failure, Fatality: Long-term Outcomes After Surgical Versus 
Nonoperative Management of Type II Odontoid Fracture in Octogenarians
AUTHOR NAMES
  Perry A.; Graffeo C.S.; Carlstrom L.P.; Chang W.; Mallory G.W.; Puffer R.C.; Clarke M.J.
AUTHOR ADDRESSES
  (Perry A.; Graffeo C.S.; Carlstrom L.P.; Chang W.; Mallory G.W.; Puffer 
R.C.; Clarke M.J., Clarke.Michelle@Mayo.edu) Department of Neurologic 
Surgery, Mayo Clinic, Rochester, United States.
CORRESPONDENCE ADDRESS
  M.J. Clarke, Department of Neurologic Surgery, Mayo Clinic, Rochester, 
United States. Email: Clarke.Michelle@Mayo.edu
AiP/IP ENTRY DATE
  2018-02-07
FULL RECORD ENTRY DATE
  2018-02-08
SOURCE
  World Neurosurgery (2018) 110 (e484-e489). Date of Publication: 1 Feb 2018
VOLUME
  110
FIRST PAGE
  e484
LAST PAGE
  e489
DATE OF PUBLICATION
  1 Feb 2018
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background Type II odontoid fracture is a highly morbid injury among 
octogenarians, with 41% 1-year mortality. Our objective was to assess 
long-term fusion, complication, and survival rates. Methods Retrospective 
review of prospective trauma registry and blinded review of follow-up 
radiographs. Results Follow-up cohort included 94 nonoperative and 17 
operative patients (median, 52 and 79 months). The operative group had 
significantly higher rates of repeated surgery for primary treatment failure 
or complication (1% vs. 18%; P = 0.01) and dysphagia, aspiration events, or 
tracheostomy (29% vs. 78%, P = 0.002; 6% vs. 30%, P = 0.04; 1% vs. 18%, P = 
0.01). Three-year all-cause mortalities were 71% and 76%, respectively (P = 
0.78). No delayed myelopathy was observed. One-year postinjury radiographs 
were available for 13 and 6 patients in the nonoperative and operative 
groups (P = 0.9); bony union was observed in 3 and 5 patients (23% vs. 83%; 
P = 0.04). Retrolisthesis greater than 2 mm was observed in 2 and 1 patients 
(15% vs. 17%; P = 1.0). Two patients in the operative group underwent 
repeated surgery for primary treatment failure. Dysphagia was diagnosed in 3 
and 5 operative patients (23% vs. 83%; P = 0.04), whereas aspiration events 
occurred in 0 and 3 patients (0% vs. 50%; P = 0.02). Three-year mortalities 
in this cohort were 38% and 67% (P = 0.35). Conclusions Radiographic union 
is significantly associated with operative management, but the corresponding 
clinical benefit is unclear. Complications were significantly more common 
after surgery. Long-term survival in octogenarians following type II 
odontoid fracture is poor, independent of management. Frequent complications 
without a proven survival benefit suggest that most patients are better 
managed conservatively.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  comparative effectiveness; conservative treatment; groups by age; odontoid process fracture (surgery, therapy); spine fusion; treatment failure; 
EMTREE MEDICAL INDEX TERMS
  aged; all cause mortality; arthrodesis; article; aspiration; cervical spine radiography; clinical outcome; cohort analysis; controlled study; dysphagia; female; follow up; fracture healing; human; long term survival; major clinical study; male; postoperative complication; register; reoperation; retrolisthesis; retrospective study; spondylolisthesis; survival rate; tracheostomy; very elderly; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180066996
MEDLINE PMID
  29155062 (http://www.ncbi.nlm.nih.gov/pubmed/29155062)
PUI
  L620429994
DOI
  10.1016/j.wneu.2017.11.020
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2017.11.020
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2017.11.020&atitle=Fusion%2C+Failure%2C+Fatality%3A+Long-term+Outcomes+After+Surgical+Versus+Nonoperative+Management+of+Type+II+Odontoid+Fracture+in+Octogenarians&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=110&issue=&spage=e484&epage=e489&aulast=Perry&aufirst=Avital&auinit=A.&aufull=Perry+A.&coden=&isbn=&pages=e484-e489&date=2018&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 113
TITLE
  Novel approach using transoral robotic surgery for resection of cervical 
spine chordoma
AUTHOR NAMES
  Mahmoud A.F.; McCann A.; Malhotra N.R.; O'Malley B.W.
AUTHOR ADDRESSES
  (Mahmoud A.F.; Malhotra N.R.; O'Malley B.W.) University of Pennsylvania, 
Philadelphia, United States.
(McCann A.) University of Kansas, School of Medicine, Kansas City, United 
States.
CORRESPONDENCE ADDRESS
  A.F. Mahmoud, University of Pennsylvania, Philadelphia, United States.
FULL RECORD ENTRY DATE
  2018-03-28
SOURCE
  Journal of Neurological Surgery, Part B: Skull Base (2018) 79 Supplement 1. 
Date of Publication: 1 Feb 2018
VOLUME
  79
DATE OF PUBLICATION
  1 Feb 2018
CONFERENCE NAME
  28th Annual Meeting North American Skull Base Society
CONFERENCE LOCATION
  Coronado, CA, United States
CONFERENCE DATE
  2018-02-16 to 2018-02-18
ISSN
  2193-6331
BOOK PUBLISHER
  Thieme Medical Publishers, Inc.
ABSTRACT
  Background: Chordomas are rare infiltrative neoplasms arising from remnants 
of the notochord and are predominantly located in the sacrum or clivus, 
whereas only 6% are located in the cervical spine. Surgical resection is the 
mainstay of treatment; however, tumor location and access often prove 
challenging, especially when attempting gross total resection. Due to 
limited visualization, a traditional approach often requires mandibulotomy, 
palatotomy, or glossotomy which introduce significant morbidity to the 
patient. Here, we present the first case in which transoral robotic surgery 
(TORS) was utilized for the resection of a midline C2 chordoma. Case Report: 
The patient is a 27-year-old man with incidentally discovered chordoma 
located in the midline C2 spine. The mass was noted to be small and did not 
involve critical surrounding structures on imaging; therefore, our goal was 
to obtain cure through en bloc resection with negative margins. Anterior 
approach preceded by posterior laminectomy was performed via TORS technique 
with assistance from image guidance technology to obtain exposure through 
the mouth. After gross total resection, reconstruction was performed with 
anterior and posterior spinal fusion with hardware and iliac spine bone 
graft. Temporary tracheostomy was performed and feeding tube placed. Closure 
achieved with local tissue myofascial advancement. Conclusion: Tumors of the 
axial spine are associated with perceived higher operative difficulty due to 
the complex anatomy of the upper cervical spine and restricted access. 
Amount of tumor resection is one of the most important prognostic factors 
affecting patient outcomes. TORS has been utilized extensively for access to 
the oropharynx due to superior visualization and maneuverability, primarily 
for resecting malignancy but also for benign disease. En bloc resection of a 
chordoma is limited by invasion of surrounding critical structures and by 
issues with access. By employing TORS approach, we overcame limitations due 
to access without introducing morbidity from traditional approaches. In this 
case, we avoided the need for mandibulotomy, palatotomy, and glossotomy. We 
advocate for the use of TORS for approach to the midline cervical spine and 
encourage providers to consider utilizing this technique.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer surgery; cervical spine; chordoma; robot assisted surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; anatomy; bone graft; cancer prognosis; case report; clinical article; computer; conference abstract; feeding tube; human; iliac bone; laminectomy; male; morbidity; mouth; oropharynx; spine fusion; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L621380552
DOI
  10.1055/s-0038-1633703
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0038-1633703
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21936331&id=doi:10.1055%2Fs-0038-1633703&atitle=Novel+approach+using+transoral+robotic+surgery+for+resection+of+cervical+spine+chordoma&stitle=J.+Neurol.+Surg.+Part+B+Skull+Base&title=Journal+of+Neurological+Surgery%2C+Part+B%3A+Skull+Base&volume=79&issue=&spage=&epage=&aulast=Mahmoud&aufirst=Ahmad+F.&auinit=A.F.&aufull=Mahmoud+A.F.&coden=&isbn=&pages=-&date=2018&auinit1=A&auinitm=F
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 114
TITLE
  Peripheral nerve pathology at fixed stage in spinal muscular atrophy with 
respiratory distress type 1
AUTHOR NAMES
  Ikeda A.; Yamashita S.; Tsuyusaki Y.; Tanaka M.; Tanaka Y.; Hashiguchi A.; Takashima H.; Goto T.
AUTHOR ADDRESSES
  (Ikeda A., azusaikeda39@gmail.com; Yamashita S.; Tsuyusaki Y.; Goto T.) 
Department of Neurology, Kanagawa Children's Medical Center, Japan.
(Tanaka M.; Tanaka Y.) Department of Pathology, Kanagawa Children's Medical 
Center, Japan.
(Hashiguchi A.; Takashima H.) Department of Neurology and Geriatrics, 
Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
CORRESPONDENCE ADDRESS
  A. Ikeda, Department of Neurology, Kanagawa Children's Medical Center, 
2-138-4, Mutsukawa, Minami-ku, Yokohama, Japan. Email: 
azusaikeda39@gmail.com
AiP/IP ENTRY DATE
  2017-09-13
FULL RECORD ENTRY DATE
  2018-08-06
SOURCE
  Brain and Development (2018) 40:2 (155-158). Date of Publication: 1 Feb 2018
VOLUME
  40
ISSUE
  2
FIRST PAGE
  155
LAST PAGE
  158
DATE OF PUBLICATION
  1 Feb 2018
ISSN
  1872-7131 (electronic)
  0387-7604
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is 
characterized by severe respiratory failure due to diaphragmatic paralysis 
and distal muscular weakness in early infancy. After an initial decline in 
respiratory state and motor function until 1–2 years of age, residual 
capabilities reach a plateau. We report the peripheral neuropathological 
findings of a patient with SMARD1 at 1 year and 1 month of age, when his 
muscle strength and respiratory symptoms had deteriorated and then 
stabilized for several months. Peripheral nerve biopsy revealed severely 
progressed axonal degeneration. This finding suggests the rapid progression 
of peripheral axonal neuropathy in SMARD1 that leads to its characteristic 
clinical course of respiratory failure and paralysis in the early infantile 
period.
EMTREE DRUG INDEX TERMS
  collagen (endogenous compound); myelin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  peripheral neuropathy; respiratory distress (diagnosis, etiology); spinal muscular atrophy (diagnosis, etiology); spinal muscular atrophy with respiratory distress type 1 (diagnosis, 
etiology); 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; areflexia; article; artificial ventilation; brain size; case report; clinical article; diaphragm paralysis; disease course; electromyography; facial expression; foot malformation; gene; gene mutation; genetic screening; heterozygote; human; hyperhidrosis; IGHMBP2 gene; male; muscle action potential; muscle cell; muscle hypotonia; muscle strength; myelinated nerve; nerve biopsy; nerve conduction; nerve fiber degeneration; nuclear magnetic resonance imaging; pes cavus; positive end expiratory pressure; respiratory failure; respiratory tract disease; respiratory tract infection; Schwann cell; sensory nerve conduction velocity; subcutaneous fat; sural nerve; tachycardia; tracheostomy; white matter; 
CAS REGISTRY NUMBERS
  collagen (9007-34-5)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170636842
MEDLINE PMID
  28899595 (http://www.ncbi.nlm.nih.gov/pubmed/28899595)
PUI
  L618217272
DOI
  10.1016/j.braindev.2017.08.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.braindev.2017.08.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18727131&id=doi:10.1016%2Fj.braindev.2017.08.004&atitle=Peripheral+nerve+pathology+at+fixed+stage+in+spinal+muscular+atrophy+with+respiratory+distress+type+1&stitle=Brain+Dev.&title=Brain+and+Development&volume=40&issue=2&spage=155&epage=158&aulast=Ikeda&aufirst=Azusa&auinit=A.&aufull=Ikeda+A.&coden=BDEVD&isbn=&pages=155-158&date=2018&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 115
TITLE
  Paradoxical Distraction with Upright Position After Halo Fixation in 2 
Patients with Atlanto-Occipital Dislocation
AUTHOR NAMES
  Clifton W.; Feindt A.; Skarupa D.; McLauchlin L.; Tavanaiepour D.; Rahmathulla G.
AUTHOR ADDRESSES
  (Clifton W.) Department of Neurological Surgery, Mayo Clinic Florida, 
Jacksonville, United States.
(Feindt A.; Skarupa D.; McLauchlin L.; Tavanaiepour D.; Rahmathulla G., 
Gazanfar.rahmathulla@jax.ufl.edu) Department of Neurological Surgery, 
University of Florida College of Medicine, Jacksonville, United States.
CORRESPONDENCE ADDRESS
  G. Rahmathulla, Department of Neurological Surgery, University of Florida 
College of Medicine, Jacksonville, United States. Email: 
Gazanfar.rahmathulla@jax.ufl.edu
AiP/IP ENTRY DATE
  2017-12-20
FULL RECORD ENTRY DATE
  2017-12-26
SOURCE
  World Neurosurgery (2018) 110 (303-308). Date of Publication: 1 Feb 2018
VOLUME
  110
FIRST PAGE
  303
LAST PAGE
  308
DATE OF PUBLICATION
  1 Feb 2018
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background Atlanto-occipital dislocation (AOD) is the most uncommon form of 
traumatic cervical spine injury. The majority of patients die before 
reaching higher-level care, and only a small percentage of patients with AOD 
survive the initial injury after receiving tertiary care. As such, there is 
a paucity of evidence-based management guidelines for treating this 
condition. Halo vest fixation has been a proposed method for interim 
stability while these patients undergo medical optimization for surgical 
intervention. There have been several reports of worsening AOD after halo 
placement. Reverse Trendelenburg position after halo fixation has been 
previously described to aid in the reduction of AOD, as well as concomitant 
atlantoaxial dislocation by gravitational downward force. Case Description 
In this series we present 2 cases of obese patients (body mass index >30) 
with AOD treated by halo fixation that had increased distraction after head 
of bed elevation. Conclusion Our theorized mechanism for this phenomenon is 
due to the downward pull of subaxial forces secondary to a large body 
habitus.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlanto occipital dislocation (diagnosis, surgery); cervical spine dislocation (diagnosis, surgery); halo fixation; spine stabilization; standing; 
EMTREE MEDICAL INDEX TERMS
  adult; article; atlantoaxial dislocation (diagnosis); avulsion injury; body mass; case report; clinical article; disease association; female; gastrostomy; Glasgow coma scale; human; hypovolemic shock; intubation; occipital cervical fusion; quadriplegia; spine fixation device; spine fusion; tracheostomy; x-ray computed tomography; young adult; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170879193
MEDLINE PMID
  29174236 (http://www.ncbi.nlm.nih.gov/pubmed/29174236)
PUI
  L619715451
DOI
  10.1016/j.wneu.2017.11.080
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2017.11.080
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2017.11.080&atitle=Paradoxical+Distraction+with+Upright+Position+After+Halo+Fixation+in+2+Patients+with+Atlanto-Occipital+Dislocation&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=110&issue=&spage=303&epage=308&aulast=Clifton&aufirst=William&auinit=W.&aufull=Clifton+W.&coden=&isbn=&pages=303-308&date=2018&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 116
TITLE
  Total aortic arch replacement using frozen elephant trunk technique with J 
Graft Open Stent Graft for distal aortic arch aneurysm
AUTHOR NAMES
  Koizumi S.; Nagasawa A.; Koyama T.
AUTHOR ADDRESSES
  (Koizumi S.; Nagasawa A.; Koyama T., koyamat@kcho.jp) Department of 
Cardiovascular Surgery, Kobe City Medical Center General Hospital, 2-1-1 
Minatojima Minamimachi Chuoku, Kobe, Japan.
CORRESPONDENCE ADDRESS
  T. Koyama, Department of Cardiovascular Surgery, Kobe City Medical Center 
General Hospital, 2-1-1 Minatojima Minamimachi Chuoku, Kobe, Japan. Email: 
koyamat@kcho.jp
AiP/IP ENTRY DATE
  2017-11-15
FULL RECORD ENTRY DATE
  2018-07-03
SOURCE
  General Thoracic and Cardiovascular Surgery (2018) 66:2 (91-94). Date of 
Publication: 1 Feb 2018
VOLUME
  66
ISSUE
  2
FIRST PAGE
  91
LAST PAGE
  94
DATE OF PUBLICATION
  1 Feb 2018
ISSN
  1863-6713 (electronic)
  1863-6705
BOOK PUBLISHER
  Springer Tokyo, orders@springer.jp
ABSTRACT
  Objectives: The J Graft Open Stent Graft, the first commercialized stent 
graft in Japan, has been available since February 2014, and we have used 
this new device as a frozen elephant trunk technique for distal aortic arch 
aneurysm. Here, we present our surgical method and result with this new 
device. Methods: Between October 2014 and October 2016, 30 patients (26 
males, mean age 74.3 ± 9.7 years) underwent total aortic arch replacement 
using the frozen elephant trunk technique with the J Graft Open Stent Graft 
for distal aortic arch aneurysm. The follow-up period was 10 months. 
Results: In-hospital mortality and 30-day mortality were 0%. Stroke occurred 
in three cases (10%), paraplegia in one case (3.3%), respiratory 
complication in two cases (6.7%), and renal failure in two cases (6.7%). 
During the follow-up period, there was no aorta- related death, and two 
patients needed an aortic operation (re-hemiarch replacement for 
pseudoaneurysm of proximal anastomotic site; axilloaxillary bypass for 
occlusion of the left subclavian artery), and two patients needed catheter 
embolization for type II endoleak for reopening of the left subclavian 
artery. Conclusion: Our short-term surgical results were acceptable. This 
new device is useful for distal aortic arch aneurysms.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic aneurysm (surgery); aortic arch surgery; distal aortic arch aneurysm (surgery); frozen elephant trunk technique; j graft open stent graft; stent graft; surgical technique; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; artery bypass; artery occlusion (surgery); article; artificial embolization; brain infarction; cerebrovascular accident; clinical article; delirium; embolism; endoleak (therapy); false aneurysm (surgery); female; hemiplegia; hospital mortality; human; kidney failure; left subclavian artery; lung complication (surgery); male; operative blood loss (surgery); paraplegia; postoperative complication; prosthetic valve endocarditis; reoperation; respiratory tract disease; seizure; spinal cord injury; thoracotomy; tracheotomy; very elderly; 
DEVICE MANUFACTURERS
   (Japan)Japan Lifeline
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170790392
MEDLINE PMID
  29119448 (http://www.ncbi.nlm.nih.gov/pubmed/29119448)
PUI
  L619181353
DOI
  10.1007/s11748-017-0856-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s11748-017-0856-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18636713&id=doi:10.1007%2Fs11748-017-0856-z&atitle=Total+aortic+arch+replacement+using+frozen+elephant+trunk+technique+with+J+Graft+Open+Stent+Graft+for+distal+aortic+arch+aneurysm&stitle=Gen.+Thorac.+Cardiovasc.+Surg.&title=General+Thoracic+and+Cardiovascular+Surgery&volume=66&issue=2&spage=91&epage=94&aulast=Koizumi&aufirst=Shigeki&auinit=S.&aufull=Koizumi+S.&coden=&isbn=&pages=91-94&date=2018&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 117
TITLE
  Pre-emptive awake airway management under dexmedetomidine sedation in a 
parturient with spinal muscular atrophy type-2
AUTHOR NAMES
  Godlewski C.A.; Castellanos P.F.
AUTHOR ADDRESSES
  (Godlewski C.A., cgodlewski@uabmc.edu) University of Alabama, Birmingham 
Medical Center, Department of Anesthesiology and Perioperative Medicine, 
Birmingham, United States.
(Castellanos P.F.) Voice and Aerodigestive Center, Birmingham, United 
States.
CORRESPONDENCE ADDRESS
  C.A. Godlewski, University of Alabama, Birmingham Medical Center, Department 
of Anesthesiology and Perioperative Medicine, Birmingham, United States. 
Email: cgodlewski@uabmc.edu
AiP/IP ENTRY DATE
  2018-01-05
FULL RECORD ENTRY DATE
  2018-09-25
SOURCE
  International Journal of Obstetric Anesthesia (2018) 33 (81-84). Date of 
Publication: 1 Feb 2018
VOLUME
  33
FIRST PAGE
  81
LAST PAGE
  84
DATE OF PUBLICATION
  1 Feb 2018
ISSN
  1532-3374 (electronic)
  0959-289X
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  Historically, pregnancy in females with spinal muscular atrophy was 
contraindicated due to the great risk to the parturient, but with improved 
management and increased survival more patients are becoming pregnant. We 
describe the management of a pregnant patient with spinal muscular atrophy 
type-2, who had severe restrictive lung disease, extensive spinal fusion 
that precluded neuraxial anesthesia, and chronic respiratory failure on 
nocturnal Bilevel Positive Airway Pressure. Airway management was further 
complicated by limited mouth opening and cervical spine ankylosis.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  dexmedetomidine; 
EMTREE DRUG INDEX TERMS
  bicarbonate (endogenous compound); epinephrine; fentanyl; glucose (drug therapy, intravenous drug administration); lidocaine; midazolam (intravenous drug administration); nitrous oxide; phenylephrine; sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  conscious sedation; respiration control; spinal muscular atrophy type 2; 
EMTREE MEDICAL INDEX TERMS
  adult; African American; anesthesia mask; anion gap; Apgar score; article; bicarbonate blood level; bradycardia; case report; cesarean section; clinical article; emergency surgery; end tidal carbon dioxide tension; endotracheal intubation; endotracheal tube; extubation; female; fetus heart rate; fetus lung; gestational age; hip dislocation; human; hypoglycemia (drug therapy); ketonuria; nasal cannula; nebulizer; neonatal intensive care unit; newborn hypoxia; operating room; operating table; oxygen nasal cannula; oxygen saturation; pediatric anesthesia; pediatric face mask; positive end expiratory pressure; posterior spine fusion; prematurity; rehydration; respiratory distress syndrome; resuscitation; shock; surgical intensive care unit; thoracolumbar spine; tracheostomy; trismus; urinary tract infection; wheelchair; 
CAS REGISTRY NUMBERS
  bicarbonate (144-55-8, 71-52-3)
  dexmedetomidine (113775-47-6)
  epinephrine (51-43-4, 55-31-2, 6912-68-1)
  fentanyl (437-38-7)
  glucose (50-99-7, 84778-64-3)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  nitrous oxide (10024-97-2)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
  sevoflurane (28523-86-6)
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Anesthesiology (24)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180007355
MEDLINE PMID
  29305266 (http://www.ncbi.nlm.nih.gov/pubmed/29305266)
PUI
  L620031641
DOI
  10.1016/j.ijoa.2017.11.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijoa.2017.11.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15323374&id=doi:10.1016%2Fj.ijoa.2017.11.001&atitle=Pre-emptive+awake+airway+management+under+dexmedetomidine+sedation+in+a+parturient+with+spinal+muscular+atrophy+type-2&stitle=Int.+J.+Obstet.+Anesth.&title=International+Journal+of+Obstetric+Anesthesia&volume=33&issue=&spage=81&epage=84&aulast=Godlewski&aufirst=C.A.&auinit=C.A.&aufull=Godlewski+C.A.&coden=IOANE&isbn=&pages=81-84&date=2018&auinit1=C&auinitm=A
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 118
TITLE
  Refractory orthostatic hypotension in a patient with a spinal cord injury: 
Treatment with droxidopa
AUTHOR NAMES
  Canosa-Hermida E.; Mondelo-García C.; Ferreiro-Velasco M.E.; Salvador-de la Barrera S.; Montoto-Marqués A.; Rodríguez-Sotillo A.; Vizoso-Hermida J.R.
AUTHOR ADDRESSES
  (Canosa-Hermida E., eva.canosa.hermida@sergas.es; Ferreiro-Velasco M.E.; 
Salvador-de la Barrera S.; Montoto-Marqués A.; Rodríguez-Sotillo A.) Spinal 
Cord Injury Unit, Spain.
(Mondelo-García C.; Vizoso-Hermida J.R.) Pharmacy Service, Instituto de 
Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario 
Universitario de A Coruña (CHUAC). Sergas. Universidade da Coruña (UDC), 
Coruña, Spain.
CORRESPONDENCE ADDRESS
  E. Canosa-Hermida, Instituto de Investigación Biomédica de A Coruña 
(INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. 
Universidade da Coruña (UDC), As Xubias, 84, Coruña, Spain. Email: 
eva.canosa.hermida@sergas.es
AiP/IP ENTRY DATE
  2017-02-01
FULL RECORD ENTRY DATE
  2018-02-12
SOURCE
  Journal of Spinal Cord Medicine (2018) 41:1 (115-118). Date of Publication: 
2 Jan 2018
VOLUME
  41
ISSUE
  1
FIRST PAGE
  115
LAST PAGE
  118
DATE OF PUBLICATION
  2 Jan 2018
ISSN
  2045-7723 (electronic)
  1079-0268
BOOK PUBLISHER
  Taylor and Francis Ltd., michael.wagreich@univie.ac.at
ABSTRACT
  Context: Orthostatic hypotension (OH) is a common complication in patients 
with a spinal cord injury, mainly affecting complete injuries above 
neurological level T6. It is generally more severe during the acute phase 
but can remain symptomatic for several years. Findings: A 65-year-old male 
with a grade ASIA A post-traumatic cervical spinal cord injury, at 
neurological level C4, presenting with symptomatic refractory OH. Increased 
blood pressure (BP) levels and an overall clinical improvement was observed 
after administering an increasing dose of droxidopa. Treatment was started 
at a dose of 100 mg twice daily (bid), one to be taken upon rising in the 
morning and another one in the afternoon, at least three hours before 
bedtime. According to the patient's symptomatic response, each individual 
dose was increased by 100 mg at 48-hour intervals. Both increased mean BP 
levels and a subjective symptomatic improvement were evidenced at a dose of 
300 mg bid. Clinical relevance: Treatment with droxidopa increases BP levels 
and improves symptoms related to refractory OH using all physical and 
pharmacological measures available. It could therefore constitute an 
effective alternative treatment for OH in patients with a spinal cord 
injury.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  droxidopa (drug combination); 
EMTREE DRUG INDEX TERMS
  etilefrine (drug combination, drug therapy); fludrocortisone (drug combination, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); orthostatic hypotension (drug therapy, therapy); 
EMTREE MEDICAL INDEX TERMS
  abdominal binder; aged; American Spinal Injury Association impairment scale; arthrodesis; article; artificial ventilation; bandages and dressings; case report; clinical article; cognition; compression stocking; decompression surgery; dizziness; drug dose increase; drug withdrawal; elevated blood pressure; evening dosage; faintness; fatigue; head injury; human; intervertebral disk hernia; lethargy; male; morning dosage; multiple trauma; osteosynthesis; quadriplegia; sitting; spine fracture; supine position; tracheostomy; traffic accident; 
CAS REGISTRY NUMBERS
  droxidopa (23651-95-8)
  etilefrine (10128-36-6, 534-87-2, 709-55-7, 943-17-9)
  fludrocortisone (127-31-1)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  28114866 (http://www.ncbi.nlm.nih.gov/pubmed/28114866)
PUI
  L614212965
DOI
  10.1080/10790268.2016.1274093
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2016.1274093
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2016.1274093&atitle=Refractory+orthostatic+hypotension+in+a+patient+with+a+spinal+cord+injury%3A+Treatment+with+droxidopa&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=41&issue=1&spage=115&epage=118&aulast=Canosa-Hermida&aufirst=Eva&auinit=E.&aufull=Canosa-Hermida+E.&coden=JSCMC&isbn=&pages=115-118&date=2018&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 119
TITLE
  A Meta-Analysis of the Influencing Factors for Tracheostomy after Cervical 
Spinal Cord Injury
AUTHOR NAMES
  Wang Y.; Guo Z.; Fan D.; Lu H.; Xie D.; Zhang D.; Jiang Y.; Li P.; Teng H.
AUTHOR ADDRESSES
  (Wang Y., wangyandyxdz@163.com; Fan D., 18363692176@163.com; Lu H., 
luhaijiang78@163.com) Weifang Medical University, No. 288 Shengli Street, 
Kuiwen District, Weifang, Shandong, China.
(Guo Z., 121185295@qq.com; Xie D., 2411664563@qq.com; Zhang D., 
spinewy@163.com; Jiang Y., yongtian818@qq.com; Teng H., 
tenghaijun89@163.com) Second Department of Spine Surgery, No. 89 Hospital of 
PLA, No. 256 Beigongxi Street, Weicheng District, Weifang, Shandong, China.
(Li P., lipeizrj@163.com) Department of Orthopedic Surgery, No. 89 Hospital 
of PLA, No. 256 Beigongxi Street, Weicheng District, Weifang, Shandong, 
China.
CORRESPONDENCE ADDRESS
  P. Li, Department of Orthopedic Surgery, No. 89 Hospital of PLA, No. 256 
Beigongxi Street, Weicheng District, Weifang, Shandong, China. Email: 
lipeizrj@163.com
AiP/IP ENTRY DATE
  2018-08-08
FULL RECORD ENTRY DATE
  2019-01-21
SOURCE
  BioMed Research International (2018) 2018 Article Number: 5895830. Date of 
Publication: 2018
VOLUME
  2018
DATE OF PUBLICATION
  2018
ISSN
  2314-6141 (electronic)
  2314-6133
BOOK PUBLISHER
  Hindawi Limited, 410 Park Avenue, 15th Floor, 287 pmb, New York, United 
States.
ABSTRACT
  Background. Traumatic cervical spinal cord injury (CSCI) is a common disease 
that has high complication, disability, and mortality rates and a poor 
prognosis. Tracheostomy is an important supportive therapy for patients with 
CSCI. However, a consensus on the predictive factors for tracheostomy after 
CSCI has not been reached. Objective. This meta-analysis study assessed the 
influencing factors for tracheostomy after CSCI. Methods. We searched for 
relevant studies on the influencing factors for tracheostomy after CSCI. The 
extracted data were analyzed using RevMan 5.3 software. We calculated the 
odds ratio (OR) or mean difference (MD) and 95% confidence intervals (CIs). 
Results. Sixteen eligible studies containing 9697 patients with CSCI were 
selected. The pooled OR (MD) and 95% CI of the influencing factors were as 
follows: age (mean ± SD): -0.98 (-4.00 to 2.03), advanced age: 1.93 (0.80 to 
4.63), sex (male): 1.29 (1.12 to 1.49), American Spinal Injury Association 
Impairment Scale (AIS) A grade: 7.79 (5.28 to 11.50), AIS B grade: 1.15 
(1.13 to 2.02), AIS C grade: 0.28 (0.20 to 0.41), AIS D grade: 0.04 (0.02 to 
0.09), neurological level of injury (upper CSCI): 2.36 (1.51 to 3.68), 
injury severity score (ISS): 8.97 (8.11 to 9.82), Glasgow Coma Scale (GCS) 
score ≤8: 6.03 (2.19 to 16.61), thoracic injury: 1.78 (1.55 to 2.04), brain 
injury: 0.96 (0.55 to 1.69), respiratory complications: 5.97 (4.03 to 8.86), 
smoking history: 1.45 (0.99 to 2.13), traffic accident injury: 1.27 (0.92 to 
1.74), and fall injury: 0.72 (0.52 to 1.01). Conclusions. The current 
evidence shows that male sex, AIS A grade, AIS B grade, neurological level 
of injury (upper CSCI), high ISS, GCS≤8, thoracic injury, and respiratory 
complications are risk factors for tracheostomy after CSCI, and AIS C grade 
and AIS D grade are protective factors. This study will allow us to use 
these factors for tracheostomy decisions and ultimately optimize airway 
management in patients with CSCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (diagnosis, surgery, therapy); risk factor; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  American Spinal Injury Association impairment scale; article; brain injury (diagnosis); Glasgow coma scale; human; injury scale; meta analysis; respiratory complication (diagnosis); respiratory tract disease (diagnosis); sex difference; smoking; systematic review; thorax injury (diagnosis); 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  30112403 (http://www.ncbi.nlm.nih.gov/pubmed/30112403)
PUI
  L623228999
DOI
  10.1155/2018/5895830
FULL TEXT LINK
  http://dx.doi.org/10.1155/2018/5895830
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23146141&id=doi:10.1155%2F2018%2F5895830&atitle=A+Meta-Analysis+of+the+Influencing+Factors+for+Tracheostomy+after+Cervical+Spinal+Cord+Injury&stitle=BioMed+Res.+Int.&title=BioMed+Research+International&volume=2018&issue=&spage=&epage=&aulast=Wang&aufirst=Yan&auinit=Y.&aufull=Wang+Y.&coden=&isbn=&pages=-&date=2018&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 120
TITLE
  Early tracheostomy in patients with traumatic cervical spinal cord injury 
appears safe and may improve outcomes
AUTHOR NAMES
  Flanagan C.D.; Childs B.R.; Moore T.A.; Vallier H.A.
AUTHOR ADDRESSES
  (Flanagan C.D., Christopher.flanagan@uhhospitals.org) Department of 
Orthopaedics, Affiliated with Case Western Reserve University School of 
Medicine, 11100 Euclid Avenue, Cleveland, United States.
(Childs B.R.; Moore T.A.; Vallier H.A.) Department of Orthopaedic Surgery, 
MetroHealth Medical Center, Cleveland, United States.
CORRESPONDENCE ADDRESS
  C.D. Flanagan, Department of Orthopaedics, Affiliated with Case Western 
Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, 
United States. Email: Christopher.flanagan@uhhospitals.org
AiP/IP ENTRY DATE
  2019-06-14
FULL RECORD ENTRY DATE
  2019-06-19
SOURCE
  Spine (2018) 43:16 (1110-1116). Date of Publication: 2018
VOLUME
  43
ISSUE
  16
FIRST PAGE
  1110
LAST PAGE
  1116
DATE OF PUBLICATION
  2018
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study Design. Retrospective case series. Objective. To characterize outcomes 
associated with tracheostomy timing following traumatic cervical spinal cord 
injury (CSCI). Summary of Background Data. The morbidity associated with 
cervical spine trauma is substantially increased in the setting of 
concomitant CSCI. Despite recent evidence, it remains uncertain if early 
tracheostomy following traumatic CSCI can improve outcomes. Methods. From 
January 1, 2007 to December 31, 2015, retrospective chart review identified 
70 patients who presented to a single Level 1 trauma center with traumatic 
CSCI and received tracheostomy for management of respiratory compromise. 
Patients were subdivided into two groups based on time from initial 
intubation to tracheostomy procedure: early (tracheostomy -7 d from initial 
intubation) and late (>7 d from initial intubation). Results. This series 
included 75.7% males and 24.3% females with mean age 50.5 years. A chest 
injury was present in 31.4% of patients. AIS A was the most common AIS score 
(41.4%), and 70.1% of patients had an injury level at C4 or above. Early 
tracheostomy was performed in 52.4% of patients. Factors most predictive of 
early tracheostomy were more severe AIS score (odds ratio [OR]=1.72) and 
higher neurological level of injury (OR=1.91) (P<0.001, pseudo-R2=0.241). 
Controlling for AIS and neurological level of injury, early tracheostomy was 
associated with fewer ventilator days (23.9 vs. 36.9, P=0.0268), fewer days 
to decannulation (53.0 vs. 74.3, P=0.0075), and shorter intensive care unit 
(ICU) stays (20.7 vs. 26.0, P=0.0217). Rates of pneumonia, surgical site 
infection, inhospital mortality, 90-day mortality, and 90-day readmission 
rates were not different between groups. Conclusion. Tracheostomy within 7 
days of intubation may improve respiratory outcomes in patients with 
traumatic CSCI, regardless of level or severity of injury, without 
increasing complication rates.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; early intervention; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  abdominal injury; adolescent; adult; aged; article; chronic obstructive lung disease; computer assisted tomography; endotracheal intubation; falling; female; hospital mortality; hospital readmission; human; injury scale; injury severity; intensive care unit; length of stay; lung contusion; major clinical study; male; medical history; medical record review; nervous system injury; nuclear magnetic resonance imaging; patient safety; pneumonia; pneumothorax; priority journal; retrospective study; rib fracture; shoulder fracture; spinal cord compression; surgical infection; thorax injury; traffic accident; treatment duration; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29283957 (http://www.ncbi.nlm.nih.gov/pubmed/29283957)
PUI
  L628040155
DOI
  10.1097/BRS.0000000000002537
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000002537
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000002537&atitle=Early+tracheostomy+in+patients+with+traumatic+cervical+spinal+cord+injury+appears+safe+and+may+improve+outcomes&stitle=Spine&title=Spine&volume=43&issue=16&spage=1110&epage=1116&aulast=Flanagan&aufirst=Christopher+D.&auinit=C.D.&aufull=Flanagan+C.D.&coden=SPIND&isbn=&pages=1110-1116&date=2018&auinit1=C&auinitm=D
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 121
TITLE
  Fibrocartilaginous emboli: An uncommon cause of spinal cord infarction
AUTHOR NAMES
  Chay W.
AUTHOR ADDRESSES
  (Chay W.) Shepherd Center, Atlanta, United States.
CORRESPONDENCE ADDRESS
  W. Chay, Shepherd Center, Atlanta, United States.
FULL RECORD ENTRY DATE
  2018-09-12
SOURCE
  Journal of Spinal Cord Medicine (2018) 41:5 (584). Date of Publication: 2018
VOLUME
  41
ISSUE
  5
FIRST PAGE
  584
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  American Academy of Spinal Cord Injury Professionals Educational Conference 
2018, ASCIP 2018
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2018-09-02 to 2018-09-05
ISSN
  2045-7723
BOOK PUBLISHER
  Taylor and Francis Ltd.
ABSTRACT
  Objective: To describe a case of spinal cord infarction in an otherwise 
healthy individual that was suspected to be from fibrocartilaginous 
embolism. Background: Fibrocartilaginous embolism (FCE) is a rare cause of 
spinal cord infarction in humans. In FCE, the spinal cord infarction is 
postulated to result from migration of fibrocartilaginous nucleus pulposus 
material through the nearby vasculature into one of the spinal cord vessels. 
This was first described in 1961 and since, several cases have been reported 
to cause infarction of the spinal cord, lung, brain, vertebrae, and ribs. 
Participants/methods: A 20 year-old left-hand dominant male was playing 
volleyball with friends when he reportedly experienced sharp pain on the 
right side of the neck after turning his head. He subsequently developed 
right arm weakness/numbness. He was taken to local ED by his friends and 
upon arrival, he could no longer move his arms or legs. In the ED, he 
started having difficulty breathing and was intubated. Initial imaging 
studies including CTA brain and neck were negative. Subsequent MRI of brain 
reportedly demonstrated multiple acute to subacute posterior circulation 
lacunar infarctions involving bilateral cerebellar hemispheres, bilateral 
medial thalami and parasagittals, and right parietal cortex. MRI cervical 
spine reportedly demonstrated cervical spinal cord hyperintensity, 
concerning for inflammatory vs ischemic myelopathy. Acute hospital course 
was significant for prolonged respiratory failure necessitating 
tracheostomy/PEG placement, and intermittent fevers. He was eventually 
medically stabilized and transferred to Shepherd Center for comprehensive 
rehabilitation. On admission to Shepherd Center, neurological testing was 
consistent with C2 AIS A SCI with sensory ZPP to L5 on the right and S1 on 
the left. At discharge, repeat ASIA exam was consistent with C1 AIS C SCI. 
Significance for SCI practice: There are a multitude of etiologies of 
non-traumatic spinal cord injuries. More commonly, infections, inflammatory 
conditions, demyelinating diseases, compressive/mass lesions, congenital 
diseases, and vascular disorders. More rare causes of spinal cord 
injury/infarction (such as FCE) should be considered if one of the more 
common etiologies is not identified. Conclusion: In an otherwise healthy 
individual who experiences a non-traumatic spinal cord injury, one should 
consider FCE as a potential cause.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  embolism; spinal cord infarction; 
EMTREE MEDICAL INDEX TERMS
  adult; arm weakness; brain infarction; case report; cell migration; cerebellum; cervical spinal cord; cervical spine; clinical article; conference abstract; demyelinating disease; dyspnea; fever; friend; hand; head; human; hypesthesia; infection; inflammation; lacunar stroke; leg; lung infarction; male; nuclear magnetic resonance imaging; nucleus pulposus; pain; parietal cortex; rehabilitation; respiratory failure; rib; spinal cord injury; spinal cord ischemia; thalamus; tracheostomy; vascularization; vertebra; volleyball; young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623800156
DOI
  10.1080/10790268.2018.1498265
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2018.1498265
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2018.1498265&atitle=Fibrocartilaginous+emboli%3A+An+uncommon+cause+of+spinal+cord+infarction&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=41&issue=5&spage=584&epage=&aulast=Chay&aufirst=Wesley&auinit=W.&aufull=Chay+W.&coden=&isbn=&pages=584-&date=2018&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 122
TITLE
  Risk factors for laryngeal penetration-aspiration in patients with acute 
traumatic cervical spinal cord injury
AUTHOR NAMES
  Ihalainen T.; Rinta-Kiikka I.; Luoto T.M.; Thesleff T.; Helminen M.; Korpijaakko-Huuhka A.-M.; Ronkainen A.
AUTHOR ADDRESSES
  (Ihalainen T., tiina.ihalainen@pshp.fi) Department of Neurosciences and 
Rehabilitation, Tampere University Hospital, PO Box 2000, Tampere, Finland.
(Ihalainen T., tiina.ihalainen@pshp.fi; Korpijaakko-Huuhka A.-M.) Faculty of 
Social Sciences, University of Tampere, Kalevantie 4, Tampere, Finland.
(Rinta-Kiikka I.) Department of Radiology, Medical Imaging Centre of 
Pirkanmaa Hospital District, Tampere University Hospital, PO Box 2000, 
Tampere, Finland.
(Luoto T.M.; Thesleff T.; Ronkainen A.) Department of Neurosurgery, Tampere 
University Hospital, PO Box 2000, Tampere, Finland.
(Helminen M.) Science Center, Tampere University Hospital, PO Box 2000, 
Tampere, Finland.
(Helminen M.) Health Sciences, Faculty of Social Sciences, University of 
Tampere, P.O. Box 100, Tampere, Finland.
CORRESPONDENCE ADDRESS
  T. Ihalainen, Department of Neurosciences and Rehabilitation, Tampere 
University Hospital, PO Box 2000, Tampere, Finland. Email: 
tiina.ihalainen@pshp.fi
AiP/IP ENTRY DATE
  2017-08-01
FULL RECORD ENTRY DATE
  2018-07-02
SOURCE
  Spine Journal (2018) 18:1 (81-87). Date of Publication: 1 Jan 2018
VOLUME
  18
ISSUE
  1
FIRST PAGE
  81
LAST PAGE
  87
DATE OF PUBLICATION
  1 Jan 2018
ISSN
  1878-1632 (electronic)
  1529-9430
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background Context Laryngeal penetration-aspiration, the entry of material 
into the airways, is considered the most severe subtype of dysphagia and is 
common among patients with acute cervical spinal cord injury (SCI). Purpose 
The aim of this study was to investigate risk factors for 
penetration-aspiration in patients with acute traumatic cervical spinal cord 
injury (TCSCI). Study Design This is a prospective cohort study. Patient 
Sample Thirty-seven patients with TCSCI were included in the study. Outcome 
Measures The highest Rosenbek penetration-aspiration scale (PAS; range 1–8) 
score of each patient was the primary outcome measure. The risk factors 
consisted of patient characteristics, demographics, and clinical signs 
observed during a clinical swallowing trial. Materials and Methods A 
clinical swallowing trial and videofluoroscopic swallowing study (VFSS) was 
performed on all patients within 28 days post injury. For group comparisons, 
the patients were divided into two groups: (1) penetrator-aspirators (PAS 
score ≥3) and (2) non-penetrator-aspirators (PAS score ≤2). Results Of the 
37 patients, 83.8% were male. The mean age at the time of the injury was 
61.2 years. Most patients had an incomplete TCSCI (78.4%) caused by a fall 
(75.7%). In the VFSS, 51.4% of the patients were penetrator-aspirators, and 
71.4% had silent aspiration. The risk factors for predicting 
penetration-aspiration were (1) necessity of bronchoscopies, (2) lower level 
of anterior cervical operation, (3) coughing, throat clearing, choking 
related to swallowing, and (4) changes in voice quality related to 
swallowing. Binary logistic regression identified coughing, throat clearing, 
choking, and changes in voice quality related to swallowing as independent 
risk factors for penetration-aspiration. Conclusions The necessity of 
bronchoscopies, postinjury lower cervical spine anterior surgery, coughing, 
throat clearing, choking, and changes in voice quality related to swallowing 
was a markedrisk factor for aspiration and penetration following a cervical 
SCI. These factors and signs should be used to suspect injury-related 
pharyngeal dysfunction and to initiate preventive measures to avoid 
complications. The clinical swallowing evaluation is a relevant adjunct in 
the management of these patients and can improve the detection of 
penetration and aspiration.
EMTREE DRUG INDEX TERMS
  iohexol (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aspiration; cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; assessment of humans; bronchoscopy; cervical vertebra; clinical article; cohort analysis; controlled study; coughing; female; fluoroscopy; human; male; outcome assessment; pharynx; priority journal; prospective study; swallowing; tracheostomy; videofluoroscopic swallowing study; voice; 
DRUG TRADE NAMES
  omnipaque  , NorwayGE Healthcare

DRUG MANUFACTURERS
   (Norway)GE Healthcare
CAS REGISTRY NUMBERS
  iohexol (66108-95-0)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170539762
MEDLINE PMID
  28673831 (http://www.ncbi.nlm.nih.gov/pubmed/28673831)
PUI
  L617527216
DOI
  10.1016/j.spinee.2017.06.033
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.spinee.2017.06.033
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18781632&id=doi:10.1016%2Fj.spinee.2017.06.033&atitle=Risk+factors+for+laryngeal+penetration-aspiration+in+patients+with+acute+traumatic+cervical+spinal+cord+injury&stitle=Spine+J.&title=Spine+Journal&volume=18&issue=1&spage=81&epage=87&aulast=Ihalainen&aufirst=Tiina&auinit=T.&aufull=Ihalainen+T.&coden=SJPOA&isbn=&pages=81-87&date=2018&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 123
TITLE
  Incidence, risk factors, and outcomes of acute respiratory distress syndrome 
among critically injured children
AUTHOR NAMES
  Killien E.; Mills B.; Watson R.S.; Vavilala M.S.; Rivara F.P.
AUTHOR ADDRESSES
  (Killien E., elizabeth.killien@seattlechildrens.org; Mills B.; Vavilala 
M.S.; Rivara F.P.) Harborview Injury Prevention and Research Center, 
University of Washington, Seattle, United States.
(Watson R.S.) Seattle Children's Hospital, Seattle, United States.
CORRESPONDENCE ADDRESS
  E. Killien, Harborview Injury Prevention and Research Center, University of 
Washington, Seattle, United States. Email: 
elizabeth.killien@seattlechildrens.org
FULL RECORD ENTRY DATE
  2018-07-16
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2018) 
197:MeetingAbstracts. Date of Publication: 2018
VOLUME
  197
ISSUE
  MeetingAbstracts
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2018
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2018-05-18 to 2018-05-23
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Rationale: While acute respiratory distress syndrome (ARDS) is a recognized 
complication of severe traumatic injury, little is known about 
trauma-related ARDS in children. It is not clear which children are at risk 
for ARDS after trauma nor how ARDS affects outcomes in this population. This 
investigation aimed to measure the incidence, risk factors, and outcomes 
associated with development of ARDS among critically injured children 
included in the largest trauma registry worldwide. Methods: We conducted a 
retrospective cohort study of patients <18 years included in the National 
Trauma Data Bank from 2007-2014. Patients with traumatic injury (excluding 
burns and drowning) admitted to an intensive care unit at a Level 1 or 2 
adult or pediatric trauma center were included. We identified patients for 
whom ARDS was recorded as a complication of their hospitalization. We 
determined associations between patient demographics, injury 
characteristics, and illness severity with development of ARDS in bivariate 
analyses and used a backwards selection model-building process with 
significance level p<0.05 to develop our final multivariable generalized 
linear model controlling for year and transfer status. Results: ARDS 
occurred in 2.01% (n=2449) of 121,891 critically injured children. Risk 
factors independently associated with development of ARDS are presented in 
the table. Patient characteristics associated with higher odds of ARDS 
included African American race (versus White) and comorbid bleeding 
disorders, congenital anomalies, stroke, and hypertension. Injury 
characteristics included motor vehicle crashes and firearm injuries, higher 
injury severity score, and presence of chest, abdominal, or spinal injuries. 
Intubation, tachypnea if unintubated, lower oxygen saturation, and lower 
Glasgow Coma Scale at hospital presentation were associated with higher odds 
of ARDS. Compared to children without ARDS, those with ARDS experienced 
longer duration of ventilation (median 5 days [IQR 2-10] versus 2 days 
[1-6], p<0.001), more frequent tracheostomy placement (15.5% versus 2.1%, 
chi2 p<0.001), and longer hospitalization (13 days [5-23] versus 4 days 
[2-7], p<0.001). Case fatality for ARDS was 19.9% versus 4.3% among children 
without ARDS (chi2 p<0.001), and 43.9% of patients with ARDS had ongoing 
care needs after discharge versus 15.6% of those without ARDS (chi2 
p<0.001). Conclusions: We provide the first description of the incidence, 
risk factors, and outcomes of ARDS among pediatric trauma patients. Early 
recognition of ARDS is essential to implementing treatment strategies 
associated with lower mortality. Improved understanding of the risk factors 
associated with ARDS following pediatric trauma may help providers 
anticipate its development and improve outcomes for severely injured 
children. (Table Presented) .
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult respiratory distress syndrome; incidence; risk factor; 
EMTREE MEDICAL INDEX TERMS
  abdominal injury; adult; African American; artificial ventilation; bivariate analysis; bleeding; burn; case fatality rate; cerebrovascular accident; child; childhood injury; cohort analysis; complication; conference abstract; congenital malformation; drowning; emergency health service; female; Glasgow coma scale; gunshot injury; hospitalization; human; hypertension; intensive care unit; intubation; major clinical study; male; motor vehicle; oxygen saturation; race; retrospective study; spine injury; tachypnea; thorax injury; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622970046
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:&atitle=Incidence%2C+risk+factors%2C+and+outcomes+of+acute+respiratory+distress+syndrome+among+critically+injured+children&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=197&issue=MeetingAbstracts&spage=&epage=&aulast=Killien&aufirst=E.&auinit=E.&aufull=Killien+E.&coden=&isbn=&pages=-&date=2018&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 124
TITLE
  Landmark spinal muscular atrophy study in pediatric patients and nerve 
conduction monitoring
AUTHOR NAMES
  Gadsden M.
AUTHOR ADDRESSES
  (Gadsden M.) Division of Neurophysiology, Ann and Robert H. Lurie Children's 
Hospital, Chicago, United States.
CORRESPONDENCE ADDRESS
  M. Gadsden, Division of Neurophysiology, Ann and Robert H. Lurie Children's 
Hospital, Chicago, United States.
FULL RECORD ENTRY DATE
  2019-01-22
SOURCE
  Neurodiagnostic Journal (2018) 58:4 (239-240). Date of Publication: 2018
VOLUME
  58
ISSUE
  4
FIRST PAGE
  239
LAST PAGE
  240
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  59th Annual Conference of the Neurodiagnostic Society, ASET 2018
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2018-08-16 to 2018-08-18
ISSN
  2375-8627
BOOK PUBLISHER
  Taylor and Francis Inc.
ABSTRACT
  In 2010, what were the possibilities of a Spinal Muscular Atrophy (SMA) Type 
I patient being able to list an arm, finger or perhaps the extraordinary, 
minute manipulation of a personal computer apparatus? The answer is 
little-to-zero in more serious cases. However, in 2018, research has deemed 
astounding possibilities. SMA is a genetic neuromuscular disorder identified 
by loss of motor function or muscle atrophy due to the lack of SMN1 gene 
(Survival Motor Neuron 1). In more serious conditions, such as Type 1, SMA 
has often been associated with short life expectancy of two years and 
quality of life limited to a respirator and almost complete immobility. 
Pre-symptomatic/symptomatic infants, as well as teens and young adults are 
being evaluated. These patients are administered Spinraza, the only approved 
treatment for SMA. Patients' motor function progress through nerve 
conduction studies (NCS) and electrical impedance myography (EIM) tests 
measure improvement in muscle resistance. Currently, patients are evaluated 
over a span of 15-420 days. This landmark study is revealing intrinsic 
advances from the archaic data. Patients are achieving micro-strides in 
muscular resistance and motor functions. We eventually anticipate that some 
SMA patients, who are identified early and are administered Spinraza, 
monitored through NCS and EIM, will not require permanent ventilation or 
tracheostomies and will achieve significant motor function, as well as an 
extended life expectancy.
EMTREE DRUG INDEX TERMS
  endogenous compound; nusinersen; survival motor neuron protein 1; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  monitoring; nerve conduction; pediatric patient; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; child; conference abstract; drug therapy; finger; human; immobility; impedance; infant; life expectancy; motor performance; myography; personal computer; quality of life; tracheostomy; ventilator; young adult; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L625954712
DOI
  10.1080/21646821.2018.1549441
FULL TEXT LINK
  http://dx.doi.org/10.1080/21646821.2018.1549441
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23758627&id=doi:10.1080%2F21646821.2018.1549441&atitle=Landmark+spinal+muscular+atrophy+study+in+pediatric+patients+and+nerve+conduction+monitoring&stitle=Neurodiagnostic+Journal&title=Neurodiagnostic+Journal&volume=58&issue=4&spage=239&epage=240&aulast=Gadsden&aufirst=Margo&auinit=M.&aufull=Gadsden+M.&coden=&isbn=&pages=239-240&date=2018&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 125
TITLE
  A study of predictors for hyponatraemia in patients with cervical spinal 
cord injury
AUTHOR NAMES
  Song P.W.; Dong F.L.; Feng C.C.; Shen Y.N.; Wang Y.; Zhang R.J.; Ge P.; Shen C.L.
AUTHOR ADDRESSES
  (Song P.W.; Dong F.L.; Feng C.C.; Zhang R.J.; Ge P.; Shen C.L., 
15955181179@163.com) Department of Spinal Surgery, First Affiliated 
Hospital, Anhui Medical University, 218 Jixi Road Shushan District, Hefei, 
China.
(Shen Y.N.) Department of Medical Imaging, Bengbu Medical College, Bengbu, 
China.
(Wang Y.) Department of Medical Imaging, First Affiliated Hospital, Anhui 
Medical University, Heifei, China.
CORRESPONDENCE ADDRESS
  C.L. Shen, Department of Spinal Surgery, First Affiliated Hospital, Anhui 
Medical University, 218 Jixi Road Shushan District, Hefei, China. Email: 
15955181179@163.com
AiP/IP ENTRY DATE
  2018-06-19
FULL RECORD ENTRY DATE
  2018-09-18
SOURCE
  Spinal Cord (2018) 56:1 (84-89). Date of Publication: 2018
VOLUME
  56
ISSUE
  1
FIRST PAGE
  84
LAST PAGE
  89
DATE OF PUBLICATION
  2018
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Objectives: The objectives of the study were to investigate the predictors 
for hyponatraemia in patients with cervical spinal cord injuries (CSCIs) and 
to define the relationship between magnetic resonance imaging (MRI) scans 
and hyponatraemia. Setting: The study was carried out at The First 
Affiliated Hospital of Anhui Medical University. Methods: A total of 292 
patients with CSCIs were retrospectively reviewed to determine the 
predictors of hyponatraemia. Fourteen variables were extracted from the 
medical records: Age, sex, blood pressure (BP), tracheostomy, serum 
potassium, serum chloride, serum bicarbonate, serum albumin, intravenous 
fluid intake and urine volume for 24 h, haematocrit, haemoglobin, 
neurological assessment and four MRI signal patterns. Univariate and 
multivariate analyses were used to determine the effect of each variable on 
hyponatraemia. Results: Eighty-two of the 270 patients (30%) developed 
hyponatraemia. Univariate analyses indicated that the following variables 
were significant predictors of hyponatraemia: Tracheostomy; the initial 
American Spinal Injury Association (ASIA) Impairment Scale (AIS) A 
assessment; and haemorrhage changes on T2-weighted MRI scans, and low BP. 
Multivariate regression analyses revealed two variables were significant 
predictors of hyponatraemia: Haemorrhage changes on T2-weighted MRI scans 
and low BP. Conclusions: Haemorrhage changes on MRI scans were closely 
associated with the onset of hyponatremia and could provide objective data 
for forecasting hyponatraemia in CSCI patients. Low BP was also a reasonable 
predictor of hyponatremia.
EMTREE DRUG INDEX TERMS
  bicarbonate (endogenous compound); chloride (endogenous compound); hemoglobin (endogenous compound); potassium (endogenous compound); serum albumin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; hyponatremia; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; American Spinal Injury Association impairment scale; article; bicarbonate blood level; bleeding; chloride blood level; female; fluid intake; hematocrit; human; hypotension; major clinical study; male; neurologic examination; nuclear magnetic resonance imaging; potassium blood level; priority journal; retrospective study; risk factor; tracheostomy; urine volume; 
CAS REGISTRY NUMBERS
  bicarbonate (144-55-8, 71-52-3)
  chloride (16887-00-6)
  hemoglobin (9008-02-0)
  potassium (7440-09-7)
  serum albumin (9048-46-8)
EMBASE CLASSIFICATIONS
  Clinical and Experimental Biochemistry (29)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180419958
MEDLINE PMID
  28895577 (http://www.ncbi.nlm.nih.gov/pubmed/28895577)
PUI
  L622531597
DOI
  10.1038/sc.2017.103
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2017.103
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fsc.2017.103&atitle=A+study+of+predictors+for+hyponatraemia+in+patients+with+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=56&issue=1&spage=84&epage=89&aulast=Song&aufirst=P.W.&auinit=P.W.&aufull=Song+P.W.&coden=SPCOF&isbn=&pages=84-89&date=2018&auinit1=P&auinitm=W
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 126
TITLE
  Cooling in quad fever: successful use of targeted temperature management for 
fever in acute traumatic cervical spinal cord injury
AUTHOR NAMES
  Addy M.J.; Kennedy C.D.; Nicholson Roberts T.C.; Boyle K.
AUTHOR ADDRESSES
  (Addy M.J.; Kennedy C.D.; Nicholson Roberts T.C.; Boyle K.) Southampton 
General Hospital, Southampton, United Kingdom.
CORRESPONDENCE ADDRESS
  M.J. Addy, Southampton General Hospital, Southampton, United Kingdom.
FULL RECORD ENTRY DATE
  2018-05-28
SOURCE
  Journal of Neurosurgical Anesthesiology (2018) 30:1 (98-99). Date of 
Publication: 1 Jan 2018
VOLUME
  30
ISSUE
  1
FIRST PAGE
  98
LAST PAGE
  99
DATE OF PUBLICATION
  1 Jan 2018
CONFERENCE NAME
  2017 Annual Scientific Meeting of the Neuro Anaesthetic and Critical Care 
Society of Great Britain and Ireland
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2017-05-18 to 2017-05-19
ISSN
  1537-1921
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Half of patients with acute traumatic spinal cord injury (SCI) 
suffer fever.1 Autonomic dysfunction leading to aberrant thermoregulation is 
thought to underlie this susceptibility. The term neurogenic fever is used 
where no identifiable etiology other than the SCI itself exists; it is a 
diagnosis of exclusion. Its incidence may be 4% to 5% in traumatic SCI.1 It 
can be progressive and fatal, a case series of 5 patients with cervical SCI 
and neurogenic fever had 100% mortality within 8 days of injury.2 We present 
a case of suspected neurogenic fever in which the patient survived with 
prolonged use of targeted temperature management (TTM). Case History: A 
previously well 61-year-old man sustained a complete C4 SCI after falling 
head first over the handle bars of his road bike. He was admitted to 
neuro-ICU in neurogenic shock. Noninvasive ventilation was commenced on 
admission but within 24 hours of injury he required tracheal intubation and 
ventilation. On day 1 his core temperature rose to 39°C, passive cooling 
measures were commenced. By day 3 it reached 41.8°C, intravascular TTM to 
37.5°C was commenced. TTM continued for 12 days (Fig. 1), with 3 failed 
attempts at cessation and a change to a surface TTM method. He underwent a 
tracheostomy on day 40 and was repatriated to a local ICU day 54. Five 
months postinjury he is decanulated and soon to be discharged home. 
Discussion: Although there is growing use of TTM in neurocritical care, this 
is predominantly for intracranial insults. Savage et al1 recent systematic 
review highlights the lack of evidence available to clinicians managing 
neurogenic fever. Indeed, challenges in this case included early recognition 
of life-threatening hyperthermia, distinguishing the cause of the fever and 
its clinical management. We found no literature to aid decision making on 
the threshold, duration, or method of cooling. There are now invasive and 
noninvasive cooling methods; we have shown that both can be efficacious in 
this condition. (Figure Presented).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; cooling; fever; 
EMTREE MEDICAL INDEX TERMS
  adult; brain; case report; case study; clinical article; conference abstract; core temperature; decision making; endotracheal intubation; head; human; hyperthermia; incidence; male; middle aged; mortality; neurological intensive care unit; noninvasive ventilation; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622250293
DOI
  10.1097/ANA.0000000000000469
FULL TEXT LINK
  http://dx.doi.org/10.1097/ANA.0000000000000469
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15371921&id=doi:10.1097%2FANA.0000000000000469&atitle=Cooling+in+quad+fever%3A+successful+use+of+targeted+temperature+management+for+fever+in+acute+traumatic+cervical+spinal+cord+injury&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=30&issue=1&spage=98&epage=99&aulast=Addy&aufirst=M.J.&auinit=M.J.&aufull=Addy+M.J.&coden=&isbn=&pages=98-99&date=2018&auinit1=M&auinitm=J
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 127
TITLE
  Increased risk of stroke in penetrating versus blunt injuries to cervical 
spine
AUTHOR NAMES
  Sullivan P.Z.; Blue R.; Leonard J.; Kung D.; Chen I.; Schuster J.
AUTHOR ADDRESSES
  (Sullivan P.Z.; Blue R.; Kung D.; Chen I.; Schuster J.) Neurosurgery, 
University of Pennsylvania, Philadelphia, United States.
(Leonard J.) Traumatology and Critical Care, University of Pennsylvania, 
Philadelphia, United States.
CORRESPONDENCE ADDRESS
  P.Z. Sullivan, Neurosurgery, University of Pennsylvania, Philadelphia, 
United States.
FULL RECORD ENTRY DATE
  2018-09-19
SOURCE
  Journal of Neurotrauma (2018) 35:16 (A33-A34). Date of Publication: 2018
VOLUME
  35
ISSUE
  16
FIRST PAGE
  A33
LAST PAGE
  A34
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  3rd Joint Symposium of the International and National Neurotrauma Societies 
and AANS/CNS Section on Neurotrauma and Critical Care
CONFERENCE LOCATION
  Toronto, ON, Canada
CONFERENCE DATE
  2018-08-11 to 2018-08-16
ISSN
  1557-9042
BOOK PUBLISHER
  Mary Ann Liebert Inc.
ABSTRACT
  Identification and treatment of vertebral artery injury in cervical spine 
trauma patients is necessary to prevent and optimally treat strokes of the 
brainstem, thalamus, posterior circulation and cerebellum. The true rate of 
stroke following penetrating vertebral artery injury is poorly described in 
the trauma and neurosurgical literature. In this series, 620 patients with 
traumatic cervical spine injuries were identified, and eighty-three 
vertebral artery injuries were found. In total, seven patients (1%) 
developed strokes consistent with the distribution of the vertebral artery 
and its branches following blunt or penetrating trauma to the cervical 
spine. Twenty patients were identified with penetrating injuries to the 
vertebral artery and five patients in this cohort demonstrated strokes that 
were consistent with vertebral artery occlusion (25%). Three patients with 
penetrating injury required embolization procedures. In contrast, among 
sixty-three patients with blunt cervical spine trauma and vertebral artery 
injury, only two patients were identified with vertebral artery distribution 
strokes (3%). None of the patients with blunt injury and stroke required 
endovascular procedures. Recovery after vertebral artery injury and stroke 
was variable and tracheostomy and PEG tube placement were required in all 
patients with penetrating trauma. Data on aspirin use for this population 
was variable, as co-morbid injuries lead to variable administration. There 
is a significantly higher risk of stroke from a penetrating versus blunt 
vertebral artery injury in this series (25% vs 3%, p = 0.002). Our results 
suggest that penetrating vertebral injuries should incite a higher level of 
suspicion for stroke in this difficult to assess population. Further, 
patients with penetrating vertebral artery injury should undergo repeat CTA 
at 7-10 days after injury to rule out development of pseudo-aneurysms or 
fistulas, as these may lead to life-threatening complications.
EMTREE DRUG INDEX TERMS
  acetylsalicylic acid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  blunt trauma; cerebrovascular accident; cervical spine injury; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial embolization; cohort analysis; complication; conference abstract; endovascular surgery; false aneurysm; female; fistula; human; major clinical study; male; percutaneous endoscopic gastrostomy tube; remission; tracheostomy; trinucleotide repeat; vertebral artery stenosis; 
CAS REGISTRY NUMBERS
  acetylsalicylic acid (493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623884313
DOI
  10.1089/neu.2018.29013.abstracts
FULL TEXT LINK
  http://dx.doi.org/10.1089/neu.2018.29013.abstracts
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15579042&id=doi:10.1089%2Fneu.2018.29013.abstracts&atitle=Increased+risk+of+stroke+in+penetrating+versus+blunt+injuries+to+cervical+spine&stitle=J.+Neurotrauma&title=Journal+of+Neurotrauma&volume=35&issue=16&spage=A33&epage=A34&aulast=Sullivan&aufirst=Patricia+Z.&auinit=P.Z.&aufull=Sullivan+P.Z.&coden=&isbn=&pages=A33-A34&date=2018&auinit1=P&auinitm=Z
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 128
TITLE
  Risk factors associated with mortality after traumatic cervical spinal cord 
injury
AUTHOR NAMES
  Higashi T.; Eguchi H.; Wakayama Y.; Sumi M.; Saito T.
AUTHOR ADDRESSES
  (Higashi T., higashi@yokohama-cu.ac.jp; Eguchi H.; Wakayama Y.; Sumi M.; 
Saito T.) Department of Orthopaedic Surgery, Yokohama City University, 
Fukuura 3-9, Kanazawa-ku, Yokohama City, Kanagawa Prefecture, Japan.
CORRESPONDENCE ADDRESS
  T. Higashi, Department of Orthopaedic Surgery, Yokohama City University, 
Fukuura 3-9, Kanazawa-ku, Yokohama City, Kanagawa Prefecture, Japan. Email: 
higashi@yokohama-cu.ac.jp
AiP/IP ENTRY DATE
  2018-11-26
FULL RECORD ENTRY DATE
  2018-11-29
SOURCE
  OTA International (2018) 1:1 Article Number: e003. Date of Publication: 2018
VOLUME
  1
ISSUE
  1
DATE OF PUBLICATION
  2018
ISSN
  2574-2167 (electronic)
BOOK PUBLISHER
  Wolters Kluwer Health, michael.richards@wolterskluwer.com
ABSTRACT
  Objectives: To investigate the mortality rate following cervical spinal cord 
injury (SCI) injury and analyze the associated risk factors. Design: 
Retrospective cohort study. Setting: One Level 1 trauma center. 
Patients/participants: A cohort of 76 patients with traumatic cervical SCI 
was reviewed between January 2010 and May 2015, of which 54 patients were 
selected for the present retrospective study. Intervention: Operative or 
conservative treatment. Main outcome measurements: The following patient 
parameters were analyzed; age, sex, American Spinal Injury Association 
(ASIA) impairment scale, neurological impairment level, injury mechanism, 
radiological findings, treatment, tracheostomy rate, and mortality. Results: 
The mean age of the patient cohort was 65 ± 17 years, with 11 females (20%) 
and 43 males (80%). A total of 16 (30%), 4 (7%), 22 (41%), and 12 patients 
(22%) were scored A, B, C, and D, respectively, on the ASIA impairment 
scale. Most of the injuries were at the C4 (30%) and C5 (33%) levels. Falls 
from standing (35%) and heights (39%) were the most common injury 
mechanisms. SCI in 40 patients (74%) occurred without major fracture or 
dislocation. Surgery was performed on 26 patients. The overall mortality was 
19%. Patients in the deceased group were significantly older at the time of 
injury, compared with those who survived. Paralysis had been more severe in 
the deceased group. A significantly high number of patients in the deceased 
group received a tracheostomy. When analyzed using a multivariate logistic 
regression model, an ASIA impairment scale of A was a significant risk 
factor for mortality. Conclusions: The risk factors associated with 
mortality were age, tracheostomy, and an ASIA impairment scale of A, the 
latter had the highest risk.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); mortality; risk factor; 
EMTREE MEDICAL INDEX TERMS
  aged; American Spinal Injury Association impairment scale; article; cohort analysis; conservative treatment; controlled study; dislocation; falling; female; fracture; human; Japan; major clinical study; male; paralysis; priority journal; retrospective study; standing; tracheostomy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180819413
PUI
  L625062047
DOI
  10.1097/OI9.0000000000000003
FULL TEXT LINK
  http://dx.doi.org/10.1097/OI9.0000000000000003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=25742167&id=doi:10.1097%2FOI9.0000000000000003&atitle=Risk+factors+associated+with+mortality+after+traumatic+cervical+spinal+cord+injury&stitle=OTA+Int.&title=OTA+International&volume=1&issue=1&spage=&epage=&aulast=Higashi&aufirst=Takayuki&auinit=T.&aufull=Higashi+T.&coden=&isbn=&pages=-&date=2018&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 129
TITLE
  Longer-term assessment of nusinersen safety/efficacy in infantile-onset 
spinal muscular atrophy: Interim analysis of shine
AUTHOR NAMES
  Finkel R.S.; Castro D.; Farrar M.A.; Tulinius M.; Krosschell K.J.; Saito K.; Zhang Y.; Bhan I.; Farwell W.; Reyna S.P.
AUTHOR ADDRESSES
  (Finkel R.S.) Nemours Children's Hospital, Orlando, United States.
(Castro D.) UT Southwestern Medical Center, Dallas, United States.
(Farrar M.A.) UNSW Medicine, UNSW Sydney and Sydney Children's Hospital, 
Randwick, Australia.
(Tulinius M.) Gothenburg University, Gothenburg, Sweden.
(Krosschell K.J.) Northwestern University, Chicago, United States.
(Saito K.) Tokyo Women's Medical University, Tokyo, Japan.
(Zhang Y.; Bhan I.; Reyna S.P.) Biogen, Cambridge, United States.
(Farwell W.) Clinical Development, Biogen, Cambridge, United States.
CORRESPONDENCE ADDRESS
  R.S. Finkel, Nemours Children's Hospital, Orlando, United States.
FULL RECORD ENTRY DATE
  2018-10-02
SOURCE
  Journal of Neuromuscular Diseases (2018) 5 Supplement 1 (S377). Date of 
Publication: 2018
VOLUME
  5
FIRST PAGE
  S377
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  15th International Congress on Neuromuscular Diseases, ICNMD 2018
CONFERENCE LOCATION
  Vienna, Austria
CONFERENCE DATE
  2018-07-06 to 2018-07-10
ISSN
  2214-3602
BOOK PUBLISHER
  IOS Press
ABSTRACT
  Background: Nusinersen is an antisense oligonucleotide approved for the 
treatment of SMA. It has demonstrated a favorable benefit:risk profile and 
shown significant and clinically meaningful efficacy on motor function 
across a broad spectrum of SMA populations, and event-free survival (time to 
death or permanent ventilation) in infantile-onset SMA. The objective of the 
current analysis was to report interim results from the SHINE study 
(NCT02594124) for patients with infantile-onset SMA (most likely to develop 
Type I) who transitioned from ENDEAR. Methods: SHINE is an open-label 
extension study for infants/children who participated in the ENDEAR, 
CHERISH, CS12, or CS3A nusinersen trials. Nusinersen doses were administered 
according to the regimen and participant's cohort from the previous trial. 
The primary endpoint is safety/tolerability; secondary endpoints include 
achievement of Hammersmith Infant Neurological Examination - Section 2 
(HINE-2) motor milestones and event-free survival defined as time to death 
or permanent ventilation (tracheostomy or ≥16 hours ventilation/day 
continuously for >21 days in the absence of acute reversible event). 
Results: The cutoff date was June 30, 2017; 89 patients transitioned from 
ENDEAR, 65/81 previously randomized to nusinersen and 24/41 to sham-control. 
Within SHINE only, 83 patients had an adverse event (AE). There were no 
treatment-related serious AEs. The most frequent AEs were pyrexia and upper 
respiratory tract infection. Mean (95% CI) change in HINE- 2 total score 
from nusinersen initiation to last observed visit was 1.1 (0.20-1.90) for 
patients who received sham-control in ENDEAR and nusinersen in SHINE 
(n=20/24) and 5.8 (4.58-7.04) for those who received nusinersen in ENDEAR 
and SHINE (n=74/81; pooled ENDEAR/SHINE data). Median (95% CI) event-free 
survival time among patients treated with sham-control in ENDEAR was 22.6 
(13.6-31.3) weeks versus 73.0 (36.3-NA) weeks among those who received 
nusinersen in ENDEAR and SHINE. Conclusion: Improvements in motor function 
and event-free survival continued among patients who initiated nusinersen in 
ENDEAR and motor function improved among those who initiated nusinersen in 
SHINE. Further analysis of SHINE data will provide additional information on 
the longterm safety/tolerability and efficacy of repeated nusinersen doses 
across multiple SMA populations.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug safety; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  achievement; adverse event; artificial ventilation; child; cohort analysis; conference abstract; controlled study; death; drug combination; drug therapy; event free survival; female; fever; human; infant; major clinical study; male; motor performance; neurologic examination; pharmacokinetics; tracheostomy; upper respiratory tract infection; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624072911
DOI
  10.3233/JND-189001
FULL TEXT LINK
  http://dx.doi.org/10.3233/JND-189001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22143602&id=doi:10.3233%2FJND-189001&atitle=Longer-term+assessment+of+nusinersen+safety%2Fefficacy+in+infantile-onset+spinal+muscular+atrophy%3A+Interim+analysis+of+shine&stitle=J.+Neuromusc.+Dis.&title=Journal+of+Neuromuscular+Diseases&volume=5&issue=&spage=S377&epage=&aulast=Finkel&aufirst=Richard+S.&auinit=R.S.&aufull=Finkel+R.S.&coden=&isbn=&pages=S377-&date=2018&auinit1=R&auinitm=S
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 130
TITLE
  Post Adjuvant neck irradiation related cervical spine arthritis mimics bony 
metastasis in MRI and PET/CT scan- A Case Report
AUTHOR NAMES
  Su C.-W.; Yen T.-Y.
AUTHOR ADDRESSES
  (Su C.-W.; Yen T.-Y.) Department of Radiation Oncology, MacKay Memorial 
Hospital, New Taipei City, Taiwan.
CORRESPONDENCE ADDRESS
  C.-W. Su, Department of Radiation Oncology, MacKay Memorial Hospital, New 
Taipei City, Taiwan.
FULL RECORD ENTRY DATE
  2018-04-03
SOURCE
  Neuroradiology (2018) 60:1 Supplement 1 (368-369). Date of Publication: 2018
VOLUME
  60
ISSUE
  1
FIRST PAGE
  368
LAST PAGE
  369
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  12th Asian-Oceanian Congress of Neuroradiology and the 21st Symposium 
Neuroradiologicum
CONFERENCE LOCATION
  Taipei, Taiwan
CONFERENCE DATE
  2018-03-19 to 2018-03-24
ISSN
  1432-1920
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  PURPOSE: To report a tongue cancer patient who had C-spine inflammatory 
arthritis mimicking bone metastasis after postoperative adjuvant 
irradiation. MATERIAL ANDMETHODS: A 54-year-old man underwent a composite 
resection for right tongue cancer with right radical neck dissection, 
mandibulotomy and tracheostomy, followed by adjuvant radiotherapy as total 
dose of 60Gy divided into 30 fractions in 2015. Five months later, he 
presented neck pain and rigidity for two weeks. The cervical spine two views 
X-ray film revealed multiple spurs formation and disc space narrowing at 
C4-5, C5-6, and C6-7 level. Pain killer, steroids and muscle relaxant were 
given but in vain. The MRI scan one week later disclosed abnormal signal 
with enhancement at T2 phase and decreased signal at T1 dark-fluid phase 
over lateral side of C1 and soft tissue surrounding occipital condyle 
(Figure1, 2). For further information, we prescribed PET/CT as well. PET/CT 
revealed increased uptake in the left superior articular facet of C1 
vertebra with osteolytic change as SUVmax: 7.4 (Figure 3). After discussion 
between radiation oncologist, ENT oncologist, and neurosurgeon, we 
prescribed oral antibiotics as fusidic acid as initial treatment for 
suspicious arthritis rather than bony metastasis due to patient's clinical 
pattern. After taking fusidic acid for several weeks, patient felt better, 
and took this oral antibiotic continually. RESULTS: After prescription 
fusidic acid for three months, this patient's neck pain and rigidity 
relieved markedly. Followed MRI scans after finishing oral antibiotics one 
month and one year later both showed dramatically improved as only mild 
enhancement at left lateral mass between C1 spine and left occipital 
condyle. CONCLUSIONS: Neck irradiation is a risk factor of C-spine 
inflammatory arthritis and it may mimic bony metastasis as osteolytic 
lesion. This benign diagnosis should be kept in mind when cancer patient 
received irradiation before. (Figure Presented).
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  adjuvant; 
EMTREE DRUG INDEX TERMS
  fusidic acid; muscle relaxant agent; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arthritis; cancer adjuvant therapy; cervical spine; first cervical vertebra; irradiation; metastasis; nuclear magnetic resonance imaging; positron emission tomography-computed tomography; 
EMTREE MEDICAL INDEX TERMS
  adjuvant radiotherapy; adult; bone atrophy; cancer patient; cancer surgery; case report; clinical article; conference abstract; diagnosis; drug therapy; human; liquid; male; middle aged; neck dissection; neck pain; neurosurgeon; osteophyte; prescription; radiation oncologist; rigidity; risk factor; soft tissue; tongue cancer; tracheostomy; X ray film; 
CAS REGISTRY NUMBERS
  fusidic acid (6990-06-3)
  muscle relaxant agent (9008-44-0)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L621458830
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14321920&id=doi:&atitle=Post+Adjuvant+neck+irradiation+related+cervical+spine+arthritis+mimics+bony+metastasis+in+MRI+and+PET%2FCT+scan-+A+Case+Report&stitle=Neuroradiology&title=Neuroradiology&volume=60&issue=1&spage=368&epage=369&aulast=Su&aufirst=Che-Wei&auinit=C.-W.&aufull=Su+C.-W.&coden=&isbn=&pages=368-369&date=2018&auinit1=C&auinitm=-W
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 131
TITLE
  Two arresting cases in the ICU
AUTHOR NAMES
  Denny J.; Bauza G.; Denny J.
AUTHOR ADDRESSES
  (Denny J.; Bauza G.; Denny J.) Rutgers Robert Wood Johnson Medical School, 
New Brunswick, NJ, 2Rutgers-Robert Wood Johnson Medical School, New 
Brunswick, NJ, 3NYU, NY, NY
CORRESPONDENCE ADDRESS
  J. Denny,
FULL RECORD ENTRY DATE
  2018-01-09
SOURCE
  Critical Care Medicine (2018) 46 Supplement 1 (54). Date of Publication: 1 
Jan 2018
VOLUME
  46
FIRST PAGE
  54
DATE OF PUBLICATION
  1 Jan 2018
CONFERENCE NAME
  47th Society of Critical Care Medicine Critical Care Congress, SCCM 2018
CONFERENCE LOCATION
  San Antonio, TX, United States
CONFERENCE DATE
  2018-02-25 to 2018-02-28
ISSN
  1530-0293
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Learning Objectives: “Out of the blue” asystole is always startling in the 
ICU. We describe two different patients who presented with multiple episodes 
of asystole in a one month period in the Surgical ICU. Differential 
diagnosis is discussed and features common to both cases are explored. This 
will enhance the ability of attendees to deal with similar such 
presentations. Methods: Case #1 was a 73-year-old restrained female 
passenger in a motor vehicle accident who sustained multiple injuries: C2 
body fracture (fx.), T3, 7, 8, 11 compression fx., L3 fx. s/p fusion, Left 
1-6 rib fxs. Hospital course included a tracheostomy and PEG, serratia 
pneumonia, and prolonged ventilator dependence. Neurologically she weakly 
moved all extremities. After 2 weeks in the ICU, she had an episode of 
asystole which resolved after 5 chest compressions. A cardiology consult 
recommended observation. Her asystole recurred 3 days later, and again 
resolved with 3 compressions. At that time, cardiology recommended a 
scopolamine patch to reduce vagal tone. No further episodes occurred. Case 
#2 was a 64-year-old male who fell 6 feet and sustained a C5 fracture with 
spinal cord injury (T4 sensory level), and underwent an ORIF of the C5 
fracture. There was also a T1 fracture, subsequently treated with a TLSO 
brace. His hospital course was complicated by neurogenic shock requiring 
norepinephrine infusion, polymicrobial pneumonia and ventilator dependence. 
After 1 week in the ICU, he also suffered asystole, which resolved after 5 
compressions. Cardiology evaluation was done. Asystole recurred and 
cardiology started a scopolamine patch with good effect. Results: Sinus 
arrest is usually followed by a junctional or ventricular escape beat. In 
these 2 ICU cases, skilled nurses were already in the patients' rooms and 
promptly began compressions, with subsequent NSR. Common causes of asystole 
include high vagal tone, a terminal rhythm after a code, and medication 
causes, among others. Notably, hypoxia usually provokes first a bradycardia, 
then possible asystole. There was no desaturation in these cases. 
Cardioaccelerator fibers occur from T1-4, and counteract vagal tone. As both 
patients also had thoracic spine injuries, this may have weakened this 
normal opposition to vagal tone. In these 2 patients, cardiology did not 
elect a pacemaker because of ongoing infection, and life expectancy of 
arguably less than one year. Successful treatment was achieved with the 
vagolytic effects of scopolamine patch.
EMTREE DRUG INDEX TERMS
  noradrenalin; scopolamine; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; artificial ventilation; brace; bradycardia; cardiac rhythm management device; cardiology; case report; differential diagnosis; female; fiber; foot; fracture; human; hypoxia; infection; infusion; life expectancy; male; middle aged; multiple trauma; nonhuman; nurse; pneumonia; resuscitation; rib; Serratia; sinus arrest; spinal cord injury; surgical intensive care unit; tracheostomy; traffic accident; vagus tone; ventilator; 
CAS REGISTRY NUMBERS
  noradrenalin (1407-84-7, 51-41-2)
  scopolamine (138-12-5, 51-34-3, 55-16-3)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L620079442
DOI
  10.1097/01.ccm.0000528162.36203.b8
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000528162.36203.b8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15300293&id=doi:10.1097%2F01.ccm.0000528162.36203.b8&atitle=Two+arresting+cases+in+the+ICU&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=46&issue=&spage=54&epage=&aulast=Denny&aufirst=John&auinit=J.&aufull=Denny+J.&coden=&isbn=&pages=54-&date=2018&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 132
TITLE
  Tracheal-spinal fistula, a late complication of tracheostomy
AUTHOR NAMES
  Jun D.; Jun J.; Martires J.; Barot N.
AUTHOR ADDRESSES
  (Jun D.) Division of Pulmonary and Critical Care, UCLA Medical Center, Los 
Angeles, United States.
(Jun J.) Department of Medicine, Olive View UCLA Medical Center, Sylmar, 
United States.
(Martires J.) Pulmonary and Critical Care, Olive View UCLA Medical Center, 
Los Angeles, United States.
(Barot N.) Olive View - UCLA Medical Center, Sylmar, United States.
CORRESPONDENCE ADDRESS
  D. Jun, Division of Pulmonary and Critical Care, UCLA Medical Center, Los 
Angeles, United States.
FULL RECORD ENTRY DATE
  2018-07-16
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2018) 
197:MeetingAbstracts. Date of Publication: 2018
VOLUME
  197
ISSUE
  MeetingAbstracts
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2018
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2018-05-18 to 2018-05-23
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Tracheostomy is commonly done to assisting patients who 
require long-term ventilator support. Despite demonstrated safety in most 
cases, tracheostomies can be associated with numerous short and long-term 
complications. Here, we describe a rare case of tracheal-spinal fistula as a 
late complication in a patient requiring long term ventilator support. 
Presentation: A 27 year-old man with Duchenne muscular dystrophy and chronic 
respiratory failure status who underwent tracheostomy in 2012 presents with 
several days of fevers, dyspnea, and increasing secretions. Patient was last 
seen in ear-nose-throat clinic a year prior for tracheostomy follow-up with 
subsequent routine care performed by the patient's mother. On admission, he 
was febrile to 39 degrees Celsius with stable hemodynamics and ventilator 
requirements. On examination, he was noted to have thick purulent secretions 
from his tracheostomy tube and diminished left lower base breath sounds. He 
also complained of tingling sensation in his left fourth and fifth digits 
with normal sensation otherwise with baseline motor weakness in his 
bilateral upper extremities. Laboratory examination showed leukocytosis with 
left shift and normal gas exchange and lactate. Chest film confirmed 
presence of a left lower lung field infiltrate consistent with pneumonia. 
Patient was started on broad-spectrum; however, despite several days of 
antibiotics the patient's fever continued and a computer tomography scan was 
obtained to better characterize his chest film findings. Here, we discovered 
that in addition to a dense left lower lobe infiltrate, the patient had 
severely dilated tracheostomy balloon with a possible fistula to the 
cervical spine. A direct laryngoscopy was performed at the bedside, 
confirming the presence of a small 2 millimeter fistulous tract along the 
right mid/central area of dilated posterior tract wall. Patient was treated 
for diskiitis and osteomyelitis with long-term ceftzidime with gradual 
neurologic improvement. Discussion: Previously described long-term 
complications of tracheostomy include recurrent pneumonias, tracheal 
stenosis, tracheomalacia, and tracheoesophageal fistulas (TEF). The latter 
is thought to be due to an iatrogenic complication during placement or 
related excessive cuff pressures causing injury to the surrounding 
structure. This case illustrates another rare complication of tracheostomy, 
likely due to similar mechanism of injury proposed in TEFs. Clinicians 
should be wary of new neurologic symptoms especially in the upper 
extremities with this condition.
EMTREE DRUG INDEX TERMS
  antibiotic agent; lactic acid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  trachea stenosis; tracheoesophageal fistula; tracheostomy tube; 
EMTREE MEDICAL INDEX TERMS
  abnormal respiratory sound; adult; artificial ventilation; balloon; bodily secretions; case report; cervical spine; chronic respiratory failure; clinical article; complication; computer assisted tomography; conference abstract; digit (body part); Duchenne muscular dystrophy; dyspnea; ear; female; fever; follow up; gas exchange; hemodynamics; human; iatrogenic disease; laboratory test; laryngoscopy; leukocytosis; male; neurologic disease; nose; osteomyelitis; pneumatic cuff; pneumonia; sensation; suppuration; thinking; thorax; throat; tracheomalacia; upper limb; ventilator; weakness; 
CAS REGISTRY NUMBERS
  lactic acid (113-21-3, 50-21-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622965710
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:&atitle=Tracheal-spinal+fistula%2C+a+late+complication+of+tracheostomy&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=197&issue=MeetingAbstracts&spage=&epage=&aulast=Jun&aufirst=D.&auinit=D.&aufull=Jun+D.&coden=&isbn=&pages=-&date=2018&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 133
TITLE
  A case of delayed diagnosis: Late onset tracheal stenosis after multiple 
short term intubations
AUTHOR NAMES
  Gao X.; Bachan M.; Khan Z.; Siegel R.E.
AUTHOR ADDRESSES
  (Gao X., gaoxiang00@gmail.com; Bachan M.; Khan Z.) James J. Peters VA 
Medical Center, Bronx, United States.
(Siegel R.E.) Bronx VA Medical Ctr, Bronx, United States.
CORRESPONDENCE ADDRESS
  X. Gao, James J. Peters VA Medical Center, Bronx, United States. Email: 
gaoxiang00@gmail.com
FULL RECORD ENTRY DATE
  2018-07-16
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2018) 
197:MeetingAbstracts. Date of Publication: 2018
VOLUME
  197
ISSUE
  MeetingAbstracts
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2018
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2018-05-18 to 2018-05-23
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Tracheal stenosis is a common complication in patients 
undergoing endotracheal intubation and can cause life threatening 
complications. However its presentations may be atypical and lead to delay 
in diagnosis. We present a case of late onset tracheal stenosis which was 
initially misdiagnosed as anxiety. Case Description: A 44-year-old man was 
admitted to Medical Intensive Care Unit (MICU) for 2 weeks' history of 
intermittent dyspnea. His history was significant for motor vehicle accident 
(MVA) which was complicated with thoracic spine fracture, paraplegia and 
multiple rib fracture with pneumothorax. He was intubated 5 times over a 
month while he was comatose. The intubations last from 2 to 6 days. He was 
successfully extubated one month after MVA and had no respiratory issues 
until his admission to MICU. He complained of generalized chest tightness 
and shortness of breath. A trial of bronchodilator failed to relieve 
symptoms. On examination patient was very anxious but speaking in full 
sentences, oxygen saturation was well maintained above 98% on room air and 
lungs were clear without any wheezing. His chest x ray was grossly normal. A 
bedside flexible fiberoptic laryngoscopy was performed for suspicion of 
possible airway stenosis, but it was reported as normal. Therefore his 
symptoms were considered more due to anxiety also since he responded to 
Lorazepam. However, during the next few days his symptoms worsened and a 
biphasic respiratory stridor developed. A CT of chest and neck showed 
possible tracheal stenosis. An urgent rigid bronchoscopy was performed and 
showed excessive granulation tissue in trachea leading to profound 
narrowing. He underwent emergent tracheostomy with tracheal tube placement. 
Symptoms were significantly relieved afterwards, and oral steroid was 
started to suppress granulation tissue formation. Discussion: In spite of 
improvement in the design of tracheal tubes, almost all patient undergoing 
translarygneal intubation develop airway stenosis, and severe stenosis 
(>50%) still occurs in approximate 19% patients. However, symptoms usually 
are not prominent especially at rest until the narrowing is more than 70% 
and can be very atypical, such as in our patient. It is crucial to maintain 
a high suspicion for tracheal stenosis in any patients with a history of 
intubation and exertional dyspnea, particularly not improving with 
bronchodilators, as immediate evaluation is needed.
EMTREE DRUG INDEX TERMS
  bronchodilating agent; lorazepam; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  delayed diagnosis; intubation; trachea stenosis; 
EMTREE MEDICAL INDEX TERMS
  adult; airway; ambient air; anxiety; bronchoscopy; case report; chest tightness; clinical article; coma; conference abstract; diagnostic error; drug therapy; dyspnea; endotracheal tube; granulation tissue; human; laryngoscopy; male; medical intensive care unit; neck; oxygen saturation; paraplegia; pneumothorax; rest; rib fracture; speech; stridor; thoracic spine; thorax radiography; tracheostomy; traffic accident; wheezing; 
CAS REGISTRY NUMBERS
  lorazepam (846-49-1)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622965753
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:&atitle=A+case+of+delayed+diagnosis%3A+Late+onset+tracheal+stenosis+after+multiple+short+term+intubations&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=197&issue=MeetingAbstracts&spage=&epage=&aulast=Gao&aufirst=X.&auinit=X.&aufull=Gao+X.&coden=&isbn=&pages=-&date=2018&auinit1=X&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 134
TITLE
  Spinal Muscular Atrophy With Respiratory Distress Type 1—A Child With 
Atypical Presentation
AUTHOR NAMES
  Chiu A.T.G.; Chan S.H.S.; Wu S.P.; Ting S.H.; Chung B.H.Y.; Chan A.O.K.; Wong V.C.N.
AUTHOR ADDRESSES
  (Chiu A.T.G.; Chan S.H.S., sophehs@hku.hk; Chung B.H.Y.; Wong V.C.N.) 
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The 
University of Hong Kong, Hong Kong.
(Wu S.P.) Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong.
(Ting S.H.) Department of Pathology and Clinical Biochemistry, Queen 
Elizabeth Hospital, Hong Kong.
(Chan A.O.K.) Department of Pathology, Queen Mary Hospital, Hong Kong.
CORRESPONDENCE ADDRESS
  S.H.S. Chan, Department of Paediatrics and Adolescent Medicine, Queen Mary 
Hospital, The University of Hong Kong, Paediatric Office, 1/F New Clinical 
Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong. Email: 
sophehs@hku.hk
AiP/IP ENTRY DATE
  2018-08-03
FULL RECORD ENTRY DATE
  2018-08-07
SOURCE
  Child Neurology Open (2018) 5. Date of Publication: 1 Jan 2018
VOLUME
  5
DATE OF PUBLICATION
  1 Jan 2018
ISSN
  2329-048X (electronic)
BOOK PUBLISHER
  SAGE Publications Ltd, info@sagepub.co.uk
ABSTRACT
  The authors report a child with spinal muscular atrophy with respiratory 
distress type 1 (SMARD1). She presented atypically with hypothyroidism and 
heart failure due to septal defects that required early heart surgery and 
microcephaly in association with cerebral atrophy and thin corpus collosum. 
The subsequent asymmetrical onset of diaphragmatic paralysis, persistent 
hypotonia, and generalized muscle weakness led to the suspicion of spinal 
muscular atrophy with respiratory distress type 1. Sanger sequencing 
confirmed a compound heterozygous mutation in the Immunoglobulin Mu Binding 
Protein 2 (IGHMBP2) gene, with a known mutation c.2362C > T (p.Arg788*) and 
a novel frameshift mutation c.2048delG (p.Gly683A1afs*50). Serial nerve 
conduction study and electromyography confirmed progressive sensorimotor 
polyneuropathy and neuronopathy. In summary, this case report describes a 
child with spinal muscular atrophy with respiratory distress type 1 also 
with congenital cardiac disease and endocrine dysfunction, expanding the 
phenotypic spectrum of this condition. A high index of suspicion is needed 
in diagnosing this rare condition to guide the management and genetic 
counseling.
EMTREE DRUG INDEX TERMS
  antihypertensive agent (drug therapy); catecholamine (endogenous compound); homovanillic acid (endogenous compound); metadrenalin (endogenous compound); noradrenalin (endogenous compound); normetadrenalin (endogenous compound); thyrotropin (endogenous compound); vanilmandelic acid (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory distress (diagnosis); spinal muscular atrophy (diagnosis, etiology); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; bladder capacity; body height; body weight; brain atrophy (diagnosis); case report; cause of death; child; clinical article; constipation; corpus callosum; developmental delay; disease classification; disease course; disease severity; echocardiography; electromyography; female; gene; gene mutation; genetic analysis; head circumference; heart atrium septum defect (diagnosis, surgery); heart ventricle septum defect (diagnosis, surgery); human; hyperhidrosis; hypertension (drug therapy); hyporeflexia; IGHMBP2 gene; intrauterine growth retardation; low birth weight; medical history; microcephaly; muscle action potential; muscle biopsy; muscle hypotonia; myelination; nerve biopsy; nerve conduction velocity; nerve fiber degeneration (diagnosis); neuroimaging; nose feeding; nuclear magnetic resonance imaging; pathogenesis; postoperative period; priority journal; sural nerve; thyroid disease; thyrotropin blood level; tracheostomy; treatment refusal; urinalysis; urinary tract infection; urosepsis; vesicoureteral reflux (diagnosis); 
CAS REGISTRY NUMBERS
  homovanillic acid (306-08-1)
  metadrenalin (5001-33-2)
  noradrenalin (1407-84-7, 51-41-2)
  normetadrenalin (97-31-4)
  thyrotropin (9002-71-5)
  vanilmandelic acid (55-10-7)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180528354
PUI
  L623231227
DOI
  10.1177/2329048X18769811
FULL TEXT LINK
  http://dx.doi.org/10.1177/2329048X18769811
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2329048X&id=doi:10.1177%2F2329048X18769811&atitle=Spinal+Muscular+Atrophy+With+Respiratory+Distress+Type+1%E2%80%94A+Child+With+Atypical+Presentation&stitle=Child+Neurol.+Open&title=Child+Neurology+Open&volume=5&issue=&spage=&epage=&aulast=Chiu&aufirst=Annie+Ting+Gee&auinit=A.T.G.&aufull=Chiu+A.T.G.&coden=&isbn=&pages=-&date=2018&auinit1=A&auinitm=T.G.
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 135
TITLE
  Blastomycosis-related acute respiratory distress syndrome successfully 
managed with extracorporeal membrane oxygenation
AUTHOR NAMES
  Pearson S.D.; Bhavani S.; Katsis J.; Banach B.; Antic T.; Patel B.K.; Naureckas E.T.
AUTHOR ADDRESSES
  (Pearson S.D.; Bhavani S.; Katsis J.; Banach B.; Antic T.; Patel B.K.; 
Naureckas E.T.) University of Chicago, Chicago, United States.
CORRESPONDENCE ADDRESS
  S.D. Pearson, University of Chicago, Chicago, United States.
FULL RECORD ENTRY DATE
  2018-07-16
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2018) 
197:MeetingAbstracts. Date of Publication: 2018
VOLUME
  197
ISSUE
  MeetingAbstracts
DATE OF PUBLICATION
  2018
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2018
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2018-05-18 to 2018-05-23
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Blastomyces dermatitidis is an endemic mycosis found primarily 
in the midwestern and south-central United States. Blastomycosis can cause 
acute or chronic pneumonia, and can rarely cause overwhelming pulmonary 
infection and related acute respiratory distress syndrome (ARDS). Case 
Description: A 21-year-old female with morbid obesity and no other past 
medical history was transferred to the University of Chicago medical 
intensive care unit for management of acute hypoxemic respiratory failure 
and spinal cord compression. She had initially presented one month prior 
with back pain and dyspnea. Chest radiography showed a right upper lobe 
opacity for which she was treated on two separate occasions for community 
acquired pneumonia. She then presented a third time for worsening dyspnea in 
addition to back pain. Her chest imaging demonstrated a diffuse military 
pattern with coincident large right sided thoracic mass at the level of 
T2-T4. Subsequent MRI showed the thoracic mass was associated with severe 
cord compression. The patient developed hypoxemia requiring high flow nasal 
cannula (HFNC) and was transferred to the University of Chicago for further 
care. Upon transfer, empiric broad spectrum antibiotics, antifungals, and 
RIPE therapy were initiated and the patient required intubation for 
worsening hypoxemia. She underwent a bronchoscopy with broncho-alveolar 
lavage revealing normal airways with thick tan mucous secretions, from which 
fungal cultures grew Blastomyces dermatitidis. She underwent percutaneous 
drainage of the thoracic mass with removal of 200 cc of frank pus which also 
demonstrated Blastomyces on culture. The patient's course was complicated by 
acute renal failure, severe acute respiratory distress syndrome with 
PaO2:FiO2 ratio < 100, and plateau pressures exceeding 40 cmH(2)O despite 
lung protective ventilation and paralysis. To allow adequate oxygenation 
while awaiting lung recovery, venovenous extracorporeal membrane oxygenation 
(ECMO) was initiated on day 2 of intubation. She was extubated to HFNC 8 
days later, ECMO support was gradually weaned, and she underwent 
decannulation on ECMO day 39. She subsequently had full recovery of renal 
function, significant neurologic recovery, and was ultimately discharged 
home on oral antifungal therapy on hospital day 76. Discussion: ARDS is an 
uncommon complication of pulmonary blastomycosis, with mortality rates 
exceeding 50% in published case series. A recent retrospective case series 
reported successful application of ECMO in four patients with 
blastomycosis-related ARDS. Although the role of ECMO in 
blastomycosis-related ARDS is far from certain, transfer to an institution 
with experience in ECMO should be considered. (Figure presented) .
EMTREE DRUG INDEX TERMS
  antibiotic agent; antifungal agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult respiratory distress syndrome; blastomycosis; extracorporeal oxygenation; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure; adult; airway; antifungal therapy; army; backache; bronchoscopy; case report; case study; clinical article; community acquired pneumonia; complication; conference abstract; drug therapy; dyspnea; female; human; hypoxemia; Illinois; intubation; kidney function; lung lavage; medical history; medical intensive care unit; morbid obesity; mortality rate; mucus secretion; nasal cannula; nervous system; nuclear magnetic resonance imaging; paralysis; percutaneous drainage; pus; remission; respiratory airflow; respiratory failure; retrospective study; spinal cord compression; thorax radiography; young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622964746
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:&atitle=Blastomycosis-related+acute+respiratory+distress+syndrome+successfully+managed+with+extracorporeal+membrane+oxygenation&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=197&issue=MeetingAbstracts&spage=&epage=&aulast=Pearson&aufirst=S.D.&auinit=S.D.&aufull=Pearson+S.D.&coden=&isbn=&pages=-&date=2018&auinit1=S&auinitm=D
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 136
TITLE
  Judicious utilisation of surgical and advanced radiotherapy resources to 
manage triple trouble: A case of synchronous dual malignancies with severe 
cervical spine deformity
AUTHOR NAMES
  Ahmad I.; Lohan R.; Chufal K.S.; Raina S.
AUTHOR ADDRESSES
  (Ahmad I., irfan.a@icloud.com) Department of Radiation Oncology, Batra 
Hospital, Medical Research Centre, New Delhi, Delhi, India.
(Lohan R.) Department of Diagnostic Radiology, Khoo Teck Puat Hospital, 
Yishun, Singapore.
(Chufal K.S.) Department of Radiation Oncology, Rajiv Gandhi Cancer 
Institute and Research Centre, New Delhi, Delhi, India.
(Raina S.) Department of Surgical Oncology, Batra Hospital, Medical Research 
Centre, New Delhi, Delhi, India.
CORRESPONDENCE ADDRESS
  I. Ahmad, Department of Radiation Oncology, Batra Hospital, Medical Research 
Centre, New Delhi, Delhi, India. Email: irfan.a@icloud.com
AiP/IP ENTRY DATE
  2018-05-18
FULL RECORD ENTRY DATE
  2018-11-06
SOURCE
  BMJ Case Reports (2018) 2018 Article Number: 225096. Date of Publication: 
2018
VOLUME
  2018
DATE OF PUBLICATION
  2018
ISSN
  1757-790X (electronic)
BOOK PUBLISHER
  BMJ Publishing Group, subscriptions@bmjgroup.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer radiotherapy; cancer surgery; disease severity; spine malformation; 
EMTREE MEDICAL INDEX TERMS
  adult; biopsy; blood analysis; cancer grading; cancer growth; cancer staging; case report; cell differentiation; chemoradiotherapy; clinical article; clinical feature; computed tomography scanner; computer assisted tomography; dysphagia; Eclipse; glossectomy; head and neck squamous cell carcinoma (diagnosis, radiotherapy, surgery); histopathology; human; human tissue; linear accelerator; male; medical examination; middle aged; mucosa inflammation (complication); neck dissection; note; nuclear magnetic resonance imaging; oropharynx airway; patient care; patient positioning; postoperative period; priority journal; pyriform sinus; radiation dose; radiotherapy planning system; respiration control; Somatom Sensation Open; thorax radiography; torticollis; tracheostomy; treatment duration; treatment outcome; tumor invasion; ulcer healing (diagnosis); xerostomia (complication); 
DEVICE TRADE NAMES
  Eclipse  Varian

  Somatom Sensation Open  , GermanySiemens

  TrueBeam  Varian

DEVICE MANUFACTURERS
   (Germany)Siemens
  Varian
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180344533
MEDLINE PMID
  29735509 (http://www.ncbi.nlm.nih.gov/pubmed/29735509)
PUI
  L622059592
DOI
  10.1136/bcr-2018-225096
FULL TEXT LINK
  http://dx.doi.org/10.1136/bcr-2018-225096
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1757790X&id=doi:10.1136%2Fbcr-2018-225096&atitle=Judicious+utilisation+of+surgical+and+advanced+radiotherapy+resources+to+manage+triple+trouble%3A+A+case+of+synchronous+dual+malignancies+with+severe+cervical+spine+deformity&stitle=BMJ+Case+Rep.&title=BMJ+Case+Reports&volume=2018&issue=&spage=&epage=&aulast=Ahmad&aufirst=Irfan&auinit=I.&aufull=Ahmad+I.&coden=&isbn=&pages=-&date=2018&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 137
TITLE
  Homozygosity for a nonsense variant in AIMP2 is associated with a 
progressive neurodevelopmental disorder with microcephaly, seizures, and 
spastic quadriparesis
AUTHOR NAMES
  Shukla A.; Das Bhowmik A.; Hebbar M.; Rajagopal K.V.; Girisha K.M.; Gupta N.; Dalal A.
AUTHOR ADDRESSES
  (Shukla A.; Hebbar M.; Girisha K.M.) Department of Medical Genetics, 
Kasturba Medical College, Manipal University, Manipal, India.
(Das Bhowmik A.; Dalal A., ashwindalal@gmail.com) Diagnostics Division, 
Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
(Rajagopal K.V.) Department of Radiodiagnosis and Imaging, Kasturba Medical 
College, Manipal University, Manipal, India.
(Gupta N., neerja17@gmail.com) Division of Genetics, Department of 
Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
CORRESPONDENCE ADDRESS
  N. Gupta, Division of Genetics, Department of Pediatrics, All India 
Institute of Medical Sciences, New Delhi, India. Email: neerja17@gmail.com
AiP/IP ENTRY DATE
  2018-01-17
FULL RECORD ENTRY DATE
  2018-08-01
SOURCE
  Journal of Human Genetics (2018) 63:1 (19-25). Date of Publication: 1 Jan 
2018
VOLUME
  63
ISSUE
  1
FIRST PAGE
  19
LAST PAGE
  25
DATE OF PUBLICATION
  1 Jan 2018
ISSN
  1435-232X (electronic)
  1434-5161
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  We ascertained two unrelated consanguineous families with two affected 
children each having microcephaly, refractory seizures, intellectual 
disability, and spastic quadriparesis. Magnetic resonance imaging showed 
atrophy of cerebrum, cerebellum and spinal cord, prominent cisterna magna, 
symmetric T2 hypo-intensities in the bilateral basal ganglia and thinning of 
corpus callosum. Whole-exome sequencing of three affected individuals 
revealed c.105C>A [p.(Tyr35Ter)] variant in AIMP2. The variant lies in a 
common homozygous region of 940 kb on chromosome 7 and is likely to have 
been inherited from a common ancestor. The phenotype noted in our subjects' 
shares marked similarity with that of hypomyelinating leukodystrophy-3 
caused by mutations in closely related gene AIMP1. We hereby report the 
first human disease associated with deleterious mutations in AIMP2.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  amino acid transfer RNA ligase (endogenous compound); 
EMTREE DRUG INDEX TERMS
  anticonvulsive agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  genetic variability; homozygosity; mental disease (etiology); microcephaly (etiology); quadriplegia (etiology); seizure (drug therapy, drug therapy, etiology); spasticity (etiology); 
EMTREE MEDICAL INDEX TERMS
  acute gastroenteritis; anteverted nostril; article; artificial ventilation; blood sampling; brain atrophy; case report; cerebellum atrophy; child; clinical article; contracture; corpus callosum; dehydration; developmental delay; electroencephalography; failure to thrive; female; genetic association; hirsutism; homozygote; human; intractable epilepsy; male; myoclonus seizure (drug therapy); neuroimaging; neurologic disease; nuclear magnetic resonance imaging; pneumonia (therapy); prognathia; school child; spike wave; spinal cord atrophy; spontaneous abortion; tonic clonic seizure; tracheostomy; whole exome sequencing; 
CAS REGISTRY NUMBERS
  amino acid transfer RNA ligase (9028-02-8)
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180027937
MEDLINE PMID
  29215095 (http://www.ncbi.nlm.nih.gov/pubmed/29215095)
PUI
  L620199695
DOI
  10.1038/s10038-017-0363-1
FULL TEXT LINK
  http://dx.doi.org/10.1038/s10038-017-0363-1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1435232X&id=doi:10.1038%2Fs10038-017-0363-1&atitle=Homozygosity+for+a+nonsense+variant+in+AIMP2+is+associated+with+a+progressive+neurodevelopmental+disorder+with+microcephaly%2C+seizures%2C+and+spastic+quadriparesis&stitle=J.+Hum.+Genet.&title=Journal+of+Human+Genetics&volume=63&issue=1&spage=19&epage=25&aulast=Shukla&aufirst=Anju&auinit=A.&aufull=Shukla+A.&coden=JHGEF&isbn=&pages=19-25&date=2018&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 138
TITLE
  Medical complications and mortality in octogenarians undergoing elective 
spinal fusion surgeries
AUTHOR NAMES
  Rajpal S.; Lee Nelson E.; Villavicencio A.T.; Telang J.; Kantha R.; Beasley K.; Burneikiene S.
AUTHOR ADDRESSES
  (Rajpal S.; Lee Nelson E.; Villavicencio A.T.; Beasley K.; Burneikiene S., 
sigitab@bnasurg.com) Boulder Neurosurgical Associates, 4743 Arapahoe Avenue, 
Suite 202, Boulder, United States.
(Rajpal S.; Villavicencio A.T.; Burneikiene S., sigitab@bnasurg.com) Justin 
Parker Neurological Institute, Boulder, United States.
(Telang J.; Kantha R.) University of Colorado Boulder, Boulder, United 
States.
CORRESPONDENCE ADDRESS
  S. Burneikiene, Boulder Neurosurgical Associates, 4743 Arapahoe Avenue, 
Suite 202, Boulder, United States. Email: sigitab@bnasurg.com
AiP/IP ENTRY DATE
  2017-11-20
FULL RECORD ENTRY DATE
  2018-07-09
SOURCE
  Acta Neurochirurgica (2018) 160:1 (171-179). Date of Publication: 1 Jan 2018
VOLUME
  160
ISSUE
  1
FIRST PAGE
  171
LAST PAGE
  179
DATE OF PUBLICATION
  1 Jan 2018
ISSN
  0942-0940 (electronic)
  0001-6268
BOOK PUBLISHER
  Springer-Verlag Wien, michaela.bolli@springer.at
ABSTRACT
  Background: The consequences of suffering postoperative complications in 
elderly undergoing spinal surgeries may be different compared to younger 
patients. The primary objective of this study was to identify the types and 
frequency of medical complications and mortality rates in patients 80 years 
of age or older undergoing elective spinal fusion surgeries for degenerative 
spinal disease. Methods: A prospective observational study with a 
retrospective chart review was performed, which included all consecutive 
patients ≥80 years old undergoing elective spinal fusion surgeries from May 
2012 to August 2015. We identified a total of 95 patients, of which 39 
cervical and 56 lumbar surgeries were performed. There were 41 female and 54 
male patients with the mean age of 82.8 years (range, 80–91). The 
perioperative complications were allocated into the following categories: 
infection, pulmonary, cardiac, gastrointestinal, hematologic, urologic, 
neurovascular, thromboembolic, and other. Baseline and postoperative 
clinical outcome scores were compared to evaluate efficacy. Results: The 
mean follow-up time was 14.8 months (range, 5 days to 37 months) with an 
overall mortality rate of 8.4%. The 30-day, 90-day, and 1-year mortality 
rates were 2.1, 2.1, and 4.2%, respectively. There were 53.9 and 71.4% 
patients with complications in the cervical and lumbar patient groups, 
respectively. The presence of general comorbidities and the number of 
intervertebral levels predicted the occurrence of perioperative 
complications. Also, longer OR times were associated with a higher number of 
complications per patient and the occurrence of a UTI. Dysphagia was a 
significant predictor in developing pneumonia and atelectasis. Conclusions: 
The incidence of perioperative medical complications and mortality rates in 
octogenarians undergoing elective spinal surgeries are quite high. The 
benefits of having surgery must be weighed against the risks of not only 
surgical but also adverse medical events. An informed decision-making 
process should include discussion of potential postoperative morbidity 
specific to this patient population in order to guide patient’s acceptance 
of higher risks and expectations postoperatively. It is also important to 
identify potential complications and adapt preventive measures in order to 
help minimize them in this patient population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  elective surgery; mortality rate; postoperative complication (complication); spine fusion; surgical mortality; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure; acute respiratory failure; aged; anemia (therapy); article; aspiration pneumonia; atelectasis; atrial fibrillation; bacteremia; blood transfusion; bronchitis; cerebrovascular accident; cervical spine; clinical outcome; comorbidity; compression fracture (surgery); congestive heart failure; deep vein thrombosis; dysphagia; esophagus perforation; failed back surgery syndrome (surgery); female; follow up; gout; heart muscle ischemia; hematoma; hospital readmission; human; hyponatremia; hypotension; inappropriate vasopressin secretion; intervertebral disk hernia (surgery); kyphoplasty; length of stay; liquorrhea; lumbar spinal stenosis (surgery); lumbar spine; lung edema (surgery); lung embolism; major clinical study; male; Mallory Weiss syndrome; medical record review; nursing home; observational study; Oswestry Disability Index; overall survival; peroperative complication; posterior lumbar interbody fusion; priority journal; prospective study; pseudarthrosis; pseudomembranous colitis; rectum prolapse; rehabilitation care; reoperation; retroperitoneal abscess; retrospective study; sepsis; seroma; Short Form 36; spinal cord decompression; spinal cord disease (surgery); spine malformation (surgery); spondylolisthesis (surgery); surgical drainage; surgical infection; tachycardia; thrombophlebitis; tracheostomy; transient ischemic attack; urinary tract infection; urine retention; very elderly; 
EMBASE CLASSIFICATIONS
  Gerontology and Geriatrics (20)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170802864
MEDLINE PMID
  29138974 (http://www.ncbi.nlm.nih.gov/pubmed/29138974)
PUI
  L619257629
DOI
  10.1007/s00701-017-3384-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00701-017-3384-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09420940&id=doi:10.1007%2Fs00701-017-3384-9&atitle=Medical+complications+and+mortality+in+octogenarians+undergoing+elective+spinal+fusion+surgeries&stitle=Acta+Neurochir.&title=Acta+Neurochirurgica&volume=160&issue=1&spage=171&epage=179&aulast=Rajpal&aufirst=Sharad&auinit=S.&aufull=Rajpal+S.&coden=ACNUA&isbn=&pages=171-179&date=2018&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 139
TITLE
  Compound heterozygous RYR1 mutations in a preterm with arthrogryposis 
multiplex congenita and prenatal CNS bleeding
AUTHOR NAMES
  Brackmann F.; Türk M.; Gratzki N.; Rompel O.; Jungbluth H.; Schröder R.; Trollmann R.
AUTHOR ADDRESSES
  (Brackmann F., florian.brackmann@uk-erlangen.de; Trollmann R.) Department of 
Pediatrics, Neuropediatrics, Friedrich-Alexander-University of 
Erlangen-Nürnberg, Erlangen, Germany.
(Türk M.) Department of Neurology, Friedrich-Alexander-University of 
Erlangen-Nürnberg, Erlangen, Germany.
(Gratzki N.) Department of Pediatrics, Neonatology, 
Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
(Rompel O.) Department of Radiology, Friedrich-Alexander-University of 
Erlangen-Nürnberg, Erlangen, Germany.
(Jungbluth H.) Department of Pediatric Neurology, Neuromuscular Service, 
Evelina Children's Hospital, St Thomas' Hospital, London, United Kingdom.
(Jungbluth H.) Randall Division of Cell and Molecular, Biophysics Muscle 
Signalling Section, King's College, London, United Kingdom.
(Jungbluth H.) Department of Basic and Clinical Neuroscience, Institute of 
Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, 
United Kingdom.
(Schröder R.) Department of Neuropathology, Friedrich-Alexander-University 
of Erlangen-Nürnberg, Erlangen, Germany.
CORRESPONDENCE ADDRESS
  F. Brackmann, Department of Pediatrics, Neuropediatrics, 
Friedrich-Alexander-University of Erlangen-Nürnberg, Loschgestr. 15, 
Erlangen, Germany. Email: florian.brackmann@uk-erlangen.de
AiP/IP ENTRY DATE
  2017-11-27
FULL RECORD ENTRY DATE
  2018-11-28
SOURCE
  Neuromuscular Disorders (2018) 28:1 (54-58). Date of Publication: 1 Jan 2018
VOLUME
  28
ISSUE
  1
FIRST PAGE
  54
LAST PAGE
  58
DATE OF PUBLICATION
  1 Jan 2018
ISSN
  1873-2364 (electronic)
  0960-8966
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  RYR1 mutations, the most common cause of non-dystrophic neuromuscular 
disorders, are associated with the malignant hyperthermia susceptibility 
(MHS) trait as well as congenital myopathies with widely variable clinical 
and histopathological manifestations. Recently, bleeding anomalies have been 
reported in association with certain RYR1 mutations. Here we report a 
preterm infant born at 32 weeks gestation with arthrogryposis multiplex 
congenita due to compound heterozygous, previously MHS-associated RYR1 
mutations, with additional signs of prenatal hemorrhage. The patient 
presented at birth with multiple joint contractures, scoliosis, severe 
thoracic rigidity and respiratory failure. He continued to depend on 
mechanical ventilation and tube feeding. Muscle histopathology showed a 
marked myopathic pattern with eccentric cores. Interestingly, the patient 
had additional unusual prenatal intraventricular hemorrhage, resulting in 
post-hemorrhagic hydrocephalus as well as epidural hemorrhage affecting the 
spinal cord. This report adds to the phenotypic variability associated with 
RYR1 mutations, and highlights possible bleeding complications in affected 
individuals.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ryanodine receptor 1 (endogenous compound); 
EMTREE DRUG INDEX TERMS
  creatine kinase (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arthrogryposis (diagnosis); brain hemorrhage (diagnosis); gene mutation; prematurity; RYR1 gene; 
EMTREE MEDICAL INDEX TERMS
  arterial pH; article; artificial ventilation; birth weight; brain radiography; case report; cesarean section; clinical article; clinical feature; computer assisted tomography; creatinine blood level; disease severity; enteric feeding; genetic analysis; genetic association; genetic counseling; genetic variability; gestation period; high frequency oscillation; histopathology; human; human tissue; hydramnios (complication); hydrocephalus; infant; joint contracture; male; muscle biopsy; muscle hypertonia; nuclear magnetic resonance imaging; percutaneous endoscopic gastrostomy; priority journal; ptosis (eyelid); respiratory failure; risk factor; scoliosis; sweating; tendon reflex; tracheotomy; whole exome sequencing; 
CAS REGISTRY NUMBERS
  creatine kinase (9001-15-4)
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170821008
PUI
  L619362002
DOI
  10.1016/j.nmd.2017.09.009
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nmd.2017.09.009
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18732364&id=doi:10.1016%2Fj.nmd.2017.09.009&atitle=Compound+heterozygous+RYR1+mutations+in+a+preterm+with+arthrogryposis+multiplex+congenita+and+prenatal+CNS+bleeding&stitle=Neuromuscular+Disord.&title=Neuromuscular+Disorders&volume=28&issue=1&spage=54&epage=58&aulast=Brackmann&aufirst=Florian&auinit=F.&aufull=Brackmann+F.&coden=NEDIE&isbn=&pages=54-58&date=2018&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 140
TITLE
  Should percussion pacing have a role in perioperative advanced cardiac life 
support?: A case report
AUTHOR NAMES
  Giordano C.; Miller J.; Keidan I.
AUTHOR ADDRESSES
  (Giordano C., CGiordano@anest.ufl.edu; Miller J.; Keidan I.) Department of 
Anesthesiology, University of Florida College of Medicine, 1600 SW Archer 
Rd, Gainesville, United States.
CORRESPONDENCE ADDRESS
  C. Giordano, Department of Anesthesiology, University of Florida College of 
Medicine, 1600 SW Archer Rd, Gainesville, United States. Email: 
CGiordano@anest.ufl.edu
AiP/IP ENTRY DATE
  2019-02-14
FULL RECORD ENTRY DATE
  2019-02-19
SOURCE
  A and A Practice (2018) 10:9 (226-228). Date of Publication: 2018
VOLUME
  10
ISSUE
  9
FIRST PAGE
  226
LAST PAGE
  228
DATE OF PUBLICATION
  2018
ISSN
  2575-3126 (electronic)
BOOK PUBLISHER
  Wolters Kluwer Health, michael.richards@wolterskluwer.com
ABSTRACT
  Percussion pacing involves using one's fist to repeatedly strike a patient's 
left sternal border in a rhythmic manner. The resulting increase in 
ventricular pressure can trigger myocardial depolarization and subsequent 
contraction. We describe the successful treatment of acute preoperative 
symptomatic sinus bradycardia with percussion pacing in a 63-year-old 
patient scheduled for placement of a gastric feeding tube after trauma 
involving spinal cord injury. Although no longer included in current 
advanced cardiovascular life support guidelines, percussion pacing may be a 
suitable alternative to chest compressions in multitrauma cases where the 
force of compressions could cause further complications.
EMTREE DRUG INDEX TERMS
  fentanyl; midazolam; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  percussion pacing; perioperative period; resuscitation; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cardiac patient; case report; clinical article; endotracheal intubation; feeding tube; heart arrhythmia; heart depolarization; heart ventricle pressure; human; long bone; male; medical history; middle aged; plethysmography; practice guideline; priority journal; sinus bradycardia; spinal cord injury; tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  midazolam (59467-70-8)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L626239807
DOI
  10.1213/XAA.0000000000000670
FULL TEXT LINK
  http://dx.doi.org/10.1213/XAA.0000000000000670
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=25753126&id=doi:10.1213%2FXAA.0000000000000670&atitle=Should+percussion+pacing+have+a+role+in+perioperative+advanced+cardiac+life+support%3F%3A+A+case+report&stitle=A+A+Pract.&title=A+and+A+Practice&volume=10&issue=9&spage=226&epage=228&aulast=Giordano&aufirst=Chris&auinit=C.&aufull=Giordano+C.&coden=&isbn=&pages=226-228&date=2018&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 141
TITLE
  Surgical and early outcomes for Type A aortic dissection with preoperative 
renal dysfunction stratified by estimated glomerular filtration rate
AUTHOR NAMES
  Zhou T.; Li J.; Sun Y.; Gu J.; Zhu K.; Wang Y.; Lai H.; Wang C.
AUTHOR ADDRESSES
  (Zhou T.; Li J.; Sun Y.; Gu J.; Zhu K.; Wang Y.; Lai H., 
lai.hao@zs-hospital.sh.cn; Wang C., wang.chunsheng@zs-hospital.sh.cn) 
Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, 
Shanghai, China.
(Zhou T.; Li J.; Sun Y.; Gu J.; Zhu K.; Wang Y.; Lai H., 
lai.hao@zs-hospital.sh.cn; Wang C., wang.chunsheng@zs-hospital.sh.cn) 
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
University, Shanghai, China.
CORRESPONDENCE ADDRESS
  H. Lai, Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, 
180 Fenglin Road, Shanghai, China. Email: lai.hao@zs-hospital.sh.cn
AiP/IP ENTRY DATE
  2019-03-29
FULL RECORD ENTRY DATE
  2019-04-03
SOURCE
  European Journal of Cardio-thoracic Surgery (2018) 54:5 (940-945). Date of 
Publication: 2018
VOLUME
  54
ISSUE
  5
FIRST PAGE
  940
LAST PAGE
  945
DATE OF PUBLICATION
  2018
ISSN
  1873-734X (electronic)
  1010-7940
BOOK PUBLISHER
  European Association for Cardio-Thoracic Surgery, info@eacts.co.uk
ABSTRACT
  OBJECTIVES: The aim of this study was to analyse the effect of preoperative 
renal dysfunction on surgical and early outcomes for patients with Type A 
aortic dissection (AAD). METHODS: From January 2016 to December 2016, 140 
patients with AAD who underwent surgical treatment at our institution were 
retrospectively analysed. According to the estimated glomerular filtration 
rate (eGFR), preoperative renal dysfunction was divided into 4 groups: 
normal (eGFR >_90 ml/min/1.73 m(2), n = 76), mild (eGFR 60–89, n = 40), 
moderate (eGFR 30–59, n = 20) and severe (eGFR <30, n = 4). RESULTS: Major 
complications included prolonged ventilation requiring tracheotomy in 15 
patients, renal replacement therapy (RRT) in 28 patients, stroke in 11 
patients and paraplegia in 4 patients. The best cut-off value of the eGFR 
for predicting postoperative RRT was 70 ml/min/1.73 m(2) (area under the 
receiver operating characteristic curve was 0.809). In-hospital mortality 
was 9.3% (6.5% in the normal group, 5% in the mild group, 20% in the 
moderate group and 50% in the severe group). Logistic regression analysis 
showed that age >60 years, moderate and severe renal dysfunction, coronary 
malperfusion and peripheral malperfusion were risk factors for in-hospital 
death. CONCLUSIONS: Total arch replacement can be safely performed in 
patients with AAD and preoperative mild renal dysfunction. Preoperative 
renal dysfunction is a risk factor for postoperative RRT, and eGFR is useful 
for predicting the requirement for postoperative RRT. Our surgical strategy 
for total arch replacement and stented elephant trunk for patients with AAD 
and mild preoperative renal dysfunction has excellent early outcomes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); estimated glomerular filtration rate; kidney disease (complication); type A aortic dissection (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aortic arch surgery; area under the curve; article; brain injury (complication); cause of death; central nervous system disease (complication); cerebrovascular accident (complication); clinical outcome; controlled study; disease severity; female; follow up; heart arrest; hospital mortality; human; incidence; logistic regression analysis; major clinical study; male; mortality rate; paraplegia (complication); postoperative period; preoperative period; priority journal; receiver operating characteristic; renal replacement therapy; retrospective study; risk assessment; risk factor; spinal cord injury (complication); surgical risk; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Urology and Nephrology (28)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29672685 (http://www.ncbi.nlm.nih.gov/pubmed/29672685)
PUI
  L626366101
DOI
  10.1093/ejcts/ezy157
FULL TEXT LINK
  http://dx.doi.org/10.1093/ejcts/ezy157
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1873734X&id=doi:10.1093%2Fejcts%2Fezy157&atitle=Surgical+and+early+outcomes+for+Type+A+aortic+dissection+with+preoperative+renal+dysfunction+stratified+by+estimated+glomerular+filtration+rate&stitle=Eur.+J.+Cardio-thorac.+Surg.&title=European+Journal+of+Cardio-thoracic+Surgery&volume=54&issue=5&spage=940&epage=945&aulast=Zhou&aufirst=Tianyu&auinit=T.&aufull=Zhou+T.&coden=EJCSE&isbn=&pages=940-945&date=2018&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 142
TITLE
  Distal Spinal Muscular Atrophy: An Overlooked Etiology of Weaning Failure in 
Children with Respiratory Insufficiency
AUTHOR NAMES
  Habibi Zoham M.; Eghbalkhah A.; Kamrani K.; Khosroshahi N.; Yousefimanesh H.; Eskandarizadeh Z.
AUTHOR ADDRESSES
  (Habibi Zoham M., mjh_7409@yahoo.com; Eghbalkhah A.; Yousefimanesh H.; 
Eskandarizadeh Z.) Department of Pediatric Intensive Care Unit, Bahrami 
Children's Hospital, Tehran University of Medical Sciences, Imam Hossein 
Square, Damavand Avenue, Tehran, Iran.
(Kamrani K.) Department of Neonatal Intensive Care Unit, Bahrami Children's 
Hospital, Tehran University of Medical Sciences, Tehran, Iran.
(Khosroshahi N.) Department of Pediatric Neurology, Bahrami Children's 
Hospital, Tehran University of Medical Sciences, Tehran, Iran.
CORRESPONDENCE ADDRESS
  M. Habibi Zoham, Department of Pediatric Intensive Care Unit, Bahrami 
Children's Hospital, Tehran University of Medical Sciences, Imam Hossein 
Square, Damavand Avenue, Tehran, Iran. Email: mjh_7409@yahoo.com
AiP/IP ENTRY DATE
  2018-01-19
FULL RECORD ENTRY DATE
  2018-08-27
SOURCE
  Journal of Pediatric Intensive Care (2018) 7:3 (159-162). Date of 
Publication: 2018
VOLUME
  7
ISSUE
  3
FIRST PAGE
  159
LAST PAGE
  162
DATE OF PUBLICATION
  2018
ISSN
  2146-4626 (electronic)
  2146-4618
BOOK PUBLISHER
  Georg Thieme Verlag, iaorl@iaorl.org
ABSTRACT
  Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a rare 
autosomal recessive neuromuscular disorder that involves the anterior horn 
motor neurons. It is a disease with a poor prognosis presenting with 
progressive distal motor weakness and respiratory insufficiency from 
diaphragmatic paralysis followed by distal muscle weakness before 6 months 
of age. With the intent to spread the awareness of this rare and 
life-threatening disease, we report a 2.5-month-old female infant with a 
subsequent diagnosis of SMARD1, who was admitted in our pediatric intensive 
care unit with chief complaint of progressive respiratory distress and poor 
feeding.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); DNA (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory distress (diagnosis); spinal muscular atrophy (diagnosis); spinal muscular atrophy with respiratory distress type 1 (diagnosis); ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  abnormal respiratory sound; antibiotic therapy; article; breech presentation; case report; cesarean section; clinical article; crackle; diaphragm paralysis; DNA sequence; exon; feeding disorder; female; fluoroscopy; gene; gene mutation; genetic analysis; genetic variation; hospital infection (drug therapy); human; human tissue; IGHMBP2 gene; infant; pediatric intensive care unit; priority journal; respiratory acidosis; septicemia (drug therapy); skin biopsy; tracheostomy; urine retention; 
CAS REGISTRY NUMBERS
  DNA (9007-49-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180029278
PUI
  L620201965
DOI
  10.1055/s-0037-1617434
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0037-1617434
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21464626&id=doi:10.1055%2Fs-0037-1617434&atitle=Distal+Spinal+Muscular+Atrophy%3A+An+Overlooked+Etiology+of+Weaning+Failure+in+Children+with+Respiratory+Insufficiency&stitle=J.+Pediatr.+Intensive+Care&title=Journal+of+Pediatric+Intensive+Care&volume=7&issue=3&spage=159&epage=162&aulast=Habibi+Zoham&aufirst=Mojdeh&auinit=M.&aufull=Habibi+Zoham+M.&coden=&isbn=&pages=159-162&date=2018&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 143
TITLE
  Screw migration and oesophageal perforation after surgery for osteosarcoma 
of the cervical spine
AUTHOR NAMES
  Denaro L.; Longo U.G.; Di Martino A.C.; Maffulli N.; Denaro V.
AUTHOR ADDRESSES
  (Denaro L., lucadenaro@hotmail.com) Neurosurgery, Department of 
Neurosciences DNS, University Hospital of Padova, Padova, Italy.
(Longo U.G., g.longo@unicampus.it; Di Martino A.C., 
a.dimartino@unicampus.it; Denaro V., denaro@unicampus.it) Department of 
Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del 
Portillo, 200, Trigoria Rome, Italy.
(Maffulli N., n.maffulli@unicampus.it) Department of Musculoskeletal 
Disorders, University of Salerno, School of Medicine and Surgery, Salerno, 
Italy.
(Maffulli N., n.maffulli@unicampus.it) Centre for Sport and Exercise 
Medicine, Queen Mary University of London, Mile End Hospital, London, United 
Kingdom.
CORRESPONDENCE ADDRESS
  U.G. Longo, Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico 
University, Via Alvaro del Portillo, 200, Trigoria Rome, Italy. Email: 
g.longo@unicampus.it
AiP/IP ENTRY DATE
  2018-01-03
FULL RECORD ENTRY DATE
  2018-09-03
SOURCE
  BMC Musculoskeletal Disorders (2017) 18:1 Article Number: 552. Date of 
Publication: 29 Dec 2017
VOLUME
  18
ISSUE
  1
DATE OF PUBLICATION
  29 Dec 2017
ISSN
  1471-2474 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Background: Even though internal fixation has expanded the indications for 
cervical spine surgery, it carries the risks of fracture or migration, with 
associated potential life threatening complications. Removal of metal work 
from the cervical spine is required in case of failure of internal fixation, 
but it can become challenging, especially when a great amount of scar tissue 
is present because of previous surgery and radiotherapy. Case presentation: 
We report a 16 year old competitive basketball athlete who underwent a 
combined anterior and posterior approach for resection of an osteosarcoma of 
the sixth cervical vertebra. Fourteen years after the index procedure, the 
patient eliminated spontaneously one screw through the intestinal tract via 
an oesophageal perforation and developed a severe dysphagia. Three revision 
surgeries were performed to remove the anterior plate because of the great 
amount of post-surgery and post-irradiation fibrosis. Conclusions: Screw 
migration and oesophageal perforation after cervical spine surgery are 
uncommon potentially life-threatening occurrences. Revision surgery may be 
challenging and it requires special skills.
EMTREE DRUG INDEX TERMS
  antiinflammatory agent (drug therapy); mesna; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone screw; cancer surgery; cervical spine; device migration (complication); esophagus perforation (complication); orthopedic surgery; osteosarcoma (diagnosis, surgery); postoperative complication (complication); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; athlete; basketball player; body weight loss; bone graft; bone plate; bone radiography; bone tumor (diagnosis); case report; clinical article; colonoscopy; computer assisted tomography; device removal; disease severity; dysphagia (complication, diagnosis); emergency ward; endoscopist; esophagus injury; fibrosis (complication); fluoroscopy; histopathology; human; human tissue; iliac crest; index finger; male; medical history; muscle contracture (diagnosis); myelography; Neck Disability Index; neck pain; neurologic examination; orthopedic cast; orthopedic fixation device; paresthesia; physiotherapy; radiotherapy; rest; spinal cord compression (diagnosis); suction drain; tendinitis (diagnosis, drug therapy); total parenteral nutrition; tracheostomy; treatment duration; tumor biopsy; 
DRUG TRADE NAMES
  uromitexan  Bristol

DRUG MANUFACTURERS
  Bristol
CAS REGISTRY NUMBERS
  mesna (19767-45-4, 3375-50-6)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Cancer (16)
  Orthopedic Surgery (33)
  Occupational Health and Industrial Medicine (35)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180001755
MEDLINE PMID
  29284452 (http://www.ncbi.nlm.nih.gov/pubmed/29284452)
PUI
  L619964760
DOI
  10.1186/s12891-017-1906-5
FULL TEXT LINK
  http://dx.doi.org/10.1186/s12891-017-1906-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14712474&id=doi:10.1186%2Fs12891-017-1906-5&atitle=Screw+migration+and+oesophageal+perforation+after+surgery+for+osteosarcoma+of+the+cervical+spine&stitle=BMC+Musculoskelet.+Disord.&title=BMC+Musculoskeletal+Disorders&volume=18&issue=1&spage=&epage=&aulast=Denaro&aufirst=Luca&auinit=L.&aufull=Denaro+L.&coden=&isbn=&pages=-&date=2017&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 144
TITLE
  Trends in Patient Care for Traumatic Spinal Injuries in the United States: A 
National Inpatient Sample Study of the Correlations with Patient Outcomes 
from 2001 to 2012
AUTHOR NAMES
  Holland C.M.; Mazur M.D.; Bisson E.F.; Schmidt M.H.; Dailey A.T.
AUTHOR ADDRESSES
  (Holland C.M.; Mazur M.D.; Bisson E.F.; Schmidt M.H.; Dailey A.T., 
neuropub@hsc.utah.edu) Department of Neurosurgery, Clinical Neurosciences 
Center, University of Utah, 175 North Medical Drive East, Salt Lake City, 
United States.
CORRESPONDENCE ADDRESS
  A.T. Dailey, Department of Neurosurgery, Clinical Neurosciences Center, 
University of Utah, 175 North Medical Drive East, Salt Lake City, United 
States. Email: neuropub@hsc.utah.edu
AiP/IP ENTRY DATE
  2017-05-30
FULL RECORD ENTRY DATE
  2019-06-19
SOURCE
  Spine (2017) 42:24 (1923-1929). Date of Publication: 15 Dec 2017
VOLUME
  42
ISSUE
  24
FIRST PAGE
  1923
LAST PAGE
  1929
DATE OF PUBLICATION
  15 Dec 2017
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study Design. A retrospective database review. Objective. The aim of this 
study was to examine whether patient characteristics, distribution of care, 
and patient outcomes for spinal cord injury (SCI) in the United States have 
changed between 2001 and 2012. Summary of Background Data. Although patient 
outcomes after cranial injury are better at high-volume centers with 
specialized, multidisciplinary teams, similar assessments have not been done 
for spinal injuries. Methods. We retrospectively reviewed the National and 
Nationwide Inpatient Samples for the years 2001, 2002, 2011, and 2012 to 
identify patients with spinal fracture with or without SCI. The demographic 
characteristics of the patient cohort, clinical course, hospital 
characteristics, interhospital transfer, and disposition were statistically 
analyzed relative to patient mortality, total hospital costs, and length of 
stay. How these data changed over this 11-year period was also evaluated. 
Results. A total of 159,875 cases were identified, with 141,737 fractures 
without SCI and 18,138 SCIs with or without fracture. There was a 
statistically significant decrease in the percentage of patients transferred 
with spine injury from 4.2% to 3.4% (P<0.001) from the early years to the 
later years and in patient transfers for SCIs (8.1% vs. 6.5%, P<0.001). 
Interestingly, the overall mortality rate (3.5% vs. 3.6%) remained unchanged 
(P=0.679), but mortality from SCI increased (6.6-7.4%, P=0.021). Conclusion. 
From 2002 to 2012, the rate of interhospital transfer of spinal injury 
patients declined, while the mortality rate for patients with SCI increased. 
Interestingly, there was an increase in transfers after spinal surgery at 
the index hospital. The decentralization of spine care may be responsible 
for the increase in mortality.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  patient care; spinal cord injury (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; controlled study; correlational study; demography; disease course; female; hospital cost; human; ICD-9-CM; length of stay; major clinical study; male; middle aged; mortality rate; priority journal; retrospective study; review; spine fracture; stomach tube; tracheostomy; treatment outcome; United States; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  28538594 (http://www.ncbi.nlm.nih.gov/pubmed/28538594)
PUI
  L616399331
DOI
  10.1097/BRS.0000000000002246
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000002246
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000002246&atitle=Trends+in+Patient+Care+for+Traumatic+Spinal+Injuries+in+the+United+States%3A+A+National+Inpatient+Sample+Study+of+the+Correlations+with+Patient+Outcomes+from+2001+to+2012&stitle=Spine&title=Spine&volume=42&issue=24&spage=1923&epage=1929&aulast=Holland&aufirst=Christopher+M.&auinit=C.M.&aufull=Holland+C.M.&coden=SPIND&isbn=&pages=1923-1929&date=2017&auinit1=C&auinitm=M
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 145
TITLE
  A service evaluation of surgical tracheostomies in the emergency theatre at 
University Hospital, Coventry: Time for a dedicated tracheostomy team?
AUTHOR NAMES
  Virdi M.; Chohan P.; Elledge R.; Townsend R.; Walton G.
AUTHOR ADDRESSES
  (Virdi M.; Chohan P.; Elledge R.; Townsend R.; Walton G.) University 
Hospitals Coventry, Warwickshire NHS Trust, United Kingdom.
CORRESPONDENCE ADDRESS
  M. Virdi, University Hospitals Coventry, Warwickshire NHS Trust, United 
Kingdom.
FULL RECORD ENTRY DATE
  2018-01-17
SOURCE
  British Journal of Oral and Maxillofacial Surgery (2017) 55:10 (e96). Date 
of Publication: 1 Dec 2017
VOLUME
  55
ISSUE
  10
FIRST PAGE
  e96
DATE OF PUBLICATION
  1 Dec 2017
CONFERENCE NAME
  Annual Scientific Meeting of the British Association of Oral and 
Maxillofacial Surgeons, BAOMS 2017
CONFERENCE LOCATION
  Birmingham, United Kingdom
CONFERENCE DATE
  2017-06-28 to 2017-09-30
ISSN
  1532-1940
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  Introduction/aims: The routine practice of surgical tracheostomy has been 
challenged by bedside percutaneous dilatational tracheostomy (PDT). Whilst 
PDT is costeffective and time-efficient, there is still a place for the open 
technique in patients with unfavourable anatomy, unstable cervical spine 
injuries and/or coagulopathies. Complication rates of the open technique are 
often lower, but booking such cases into busy emergency theatres may prove 
difficult. Material/methods: We conducted a prospective service evaluation 
of all surgical tracheostomies referred to ENT and Maxillofacial surgeons 
from the Intensive Care Unit over a 6-month period. Results/statistics: 
There were 39 patients referred who had been intubated for a mean (SD) of 
7.3 (4.0) days at the point of referral. Following referral, 21/39 were 
delayed beyond one day, with a mean time to surgical tracheostomy provision 
of 2.2 (0.9) days. The commonest reasons for delay were surgeon decision 
(13/21) and theatre availability (7/21). Surgeons often cited an 
unwillingness to perform surgical tracheostomies outside of elective lists 
and clashes with planned clinical commitments. Conclusions/clinical 
relevance: We feel that there is an argument for a dedicated theatre slot to 
provide surgical tracheostomies in our unit. The average cost of an ICU bed 
increased from £1,551 to £1,647 in the period 1999-2006. Ever increasing 
costs coupled with a predicted rise in demand for Critical Care bed-days 
of4%per annum highlight the need to facilitate early discharges from ICU. 
Identifying candidates for surgical tracheostomy early and ensuring theatre 
and surgeon availability may help curb these costs and provide a more 
efficient service.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency; tracheostomy; university hospital; 
EMTREE MEDICAL INDEX TERMS
  clinical article; dental surgeon; female; human; intensive care unit; male; patient referral; prospective study; statistics; surgery; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L620182366
DOI
  10.1016/j.bjoms.2017.08.038
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.bjoms.2017.08.038
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15321940&id=doi:10.1016%2Fj.bjoms.2017.08.038&atitle=A+service+evaluation+of+surgical+tracheostomies+in+the+emergency+theatre+at+University+Hospital%2C+Coventry%3A+Time+for+a+dedicated+tracheostomy+team%3F&stitle=Br.+J.+Oral+Maxillofac.+Surg.&title=British+Journal+of+Oral+and+Maxillofacial+Surgery&volume=55&issue=10&spage=e96&epage=&aulast=Virdi&aufirst=Miesha&auinit=M.&aufull=Virdi+M.&coden=&isbn=&pages=e96-&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 146
TITLE
  Acute flaccid paralysis by Enterovirus D68 infection: First Italian 
description on adult patient and role of electrophysiology
AUTHOR NAMES
  Ceccanti M.; Rubino A.; Romanzi F.; Onesti E.; Tartaglia G.; Inghilleri M.
AUTHOR ADDRESSES
  (Ceccanti M.; Rubino A.; Romanzi F.; Onesti E.; Tartaglia G.; Inghilleri M.) 
Roma, Italy.
CORRESPONDENCE ADDRESS
  M. Ceccanti, Roma, Italy.
FULL RECORD ENTRY DATE
  2017-12-18
SOURCE
  Clinical Neurophysiology (2017) 128:12 (e430). Date of Publication: 1 Dec 
2017
VOLUME
  128
ISSUE
  12
FIRST PAGE
  e430
DATE OF PUBLICATION
  1 Dec 2017
CONFERENCE NAME
  62nd National Congress of the Italian Society for Clinical Neurophysiology
CONFERENCE LOCATION
  Ferrara, Italy
CONFERENCE DATE
  2017-06-21 to 2017-06-24
ISSN
  1872-8952
BOOK PUBLISHER
  Elsevier Ireland Ltd
ABSTRACT
  A Peruvian woman was admitted to the Emergency Department of “Policlinico 
Umberto I” in Rome for drop head associated to an acute flaccid paralysis of 
the upper limbs, beginning from the proximal muscles and rapidly extending 
to the distal. No sensory involvement was objectified. Her clinical history 
was significant for Non- Hodgkin Lymphoma and hematopoietic stem cell 
transplantation, complicated with a chronic graft-versus-host disease. 
Medullar spinal cord MRI showed a long tract of T2 hyperintensity in the 
anterior and central region of the cervical cord, with an elective 
involvement of grey matter. Lumbar puncture showed pleocytosis. An early NCS 
and EMG exam demonstrated reduction in cMAP amplitude from Ulnar and Median 
nerves bilaterally with absence of F-waves, with normal sensory conduction. 
Phrenic nerve assessment revealed bilateral reduction in amplitude. Severe 
reduction in spatial recruitment, doublets and triplets were also detected 
in the needle examination of upper limbs. Normal SEP were registered. 
Entherovirus D68, a polio-like virus firstly isolated in US in 2014, was 
isolated in patient's cerebrospinal fluid, plasma and throat swab. 
Intravenous immunoglobulins, together with steroids and Acyclovir, were 
dispensed as replacement therapy and passive immunization, with no effect. 
Patient underwent to tracheostomy and died after two weeks from 
hospitalization.
EMTREE DRUG INDEX TERMS
  aciclovir; endogenous compound; immunoglobulin; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  electrophysiology; Enterovirus D68; flaccid paralysis; poliomyelitis; 
EMTREE MEDICAL INDEX TERMS
  adult; cerebrospinal fluid; cervical spinal cord; chronic graft versus host disease; emergency ward; female; gray matter; head; hematopoietic stem cell transplantation; Hodgkin disease; hospitalization; human; human tissue; lumbar puncture; median nerve; medulla oblongata; muscle; nuclear magnetic resonance imaging; passive immunization; Peruvian; phrenic nerve; plasma; pleocytosis; substitution therapy; throat culture; tracheostomy; ulna; upper limb; 
CAS REGISTRY NUMBERS
  aciclovir (59277-89-3)
  immunoglobulin (9007-83-4)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619673720
DOI
  10.1016/j.clinph.2017.09.071
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clinph.2017.09.071
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18728952&id=doi:10.1016%2Fj.clinph.2017.09.071&atitle=Acute+flaccid+paralysis+by+Enterovirus+D68+infection%3A+First+Italian+description+on+adult+patient+and+role+of+electrophysiology&stitle=Clin.+Neurophysiol.&title=Clinical+Neurophysiology&volume=128&issue=12&spage=e430&epage=&aulast=Ceccanti&aufirst=M.&auinit=M.&aufull=Ceccanti+M.&coden=&isbn=&pages=e430-&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 147
TITLE
  Weaning outcomes of mechanically ventilated spinal cord injured persons with 
acute tetraplegia admitted to a regional UK centre over a 10 year period
AUTHOR NAMES
  Chakrabarti B.; Forrest A.; Bevan M.; Ward A.; Chaudhary K.; Soni B.; Selmi F.; Parker R.; Plant P.K.; Manuel A.; Duffy N.; Lari S.; Angus R.M.
AUTHOR ADDRESSES
  (Chakrabarti B.; Parker R.; Plant P.K.; Manuel A.; Duffy N.; Angus R.M.) 
University Hospital Aintree, Liverpool, United Kingdom.
(Forrest A.; Bevan M.; Ward A.; Chaudhary K.; Soni B.; Selmi F.; Lari S.) 
North West Regional Spinal Injuries Centre, Southport and Ormskirk Hospital, 
Southport, United Kingdom.
CORRESPONDENCE ADDRESS
  B. Chakrabarti, University Hospital Aintree, Liverpool, United Kingdom.
FULL RECORD ENTRY DATE
  2017-12-20
SOURCE
  Thorax (2017) 72 Supplement 3 (A151). Date of Publication: 1 Dec 2017
VOLUME
  72
FIRST PAGE
  A151
DATE OF PUBLICATION
  1 Dec 2017
CONFERENCE NAME
  British Thoracic Society Winter Meeting, BTS 2017
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2017-12-06 to 2017-12-08
ISSN
  1468-3296
BOOK PUBLISHER
  BMJ Publishing Group
ABSTRACT
  Introduction The occurrence of Spinal Cord Injury (SCI) is often complicated 
by the need for assisted ventilation. This study charts the weaning outcomes 
of mechanically ventilated SCI subjects admitted over a 10 year period to a 
regional Spinal Injuries unit. Methodology Acute SCI subjects with 
Tetraplegia admitted from April 2007-2017 to the Northwest Regional Spinal 
Injuries Centre (NWRSIC) were identified. Only those presenting with all 3 
criteria: A) admission injury level C1-C6 b) admission ASIA score A-C and c) 
need for mechanical ventilation on arrival to the NWRSIC were included in 
the final analysis. Results The cohort consisted of 84 subjects (mean age 57 
(SD 18) years; 76% male; 81 surviving to discharge). On admission, the level 
of injury was C1-3 in 28% (C1-3 ASIA A 20%; C1-3 ASIA B 2%; C1-3 ASIA C 6%) 
and C4-6 in 72% (C4-6 ASIA A 38%; C4-6 ASIA B 17%; C4-6 ASIA C 17%). On 
admission, 86% (72/84) were tracheostomy ventilated 24 hours/day, 12% 
(10/84) tracheostomy ventilated at night only and 2% (2/84) using NIV. By 
discharge, 13% (11/ 81) were tracheostomy ventilated 24 hours/day (including 
2 Phrenic nerve paced), 13% (11/81) tracheostomy ventilated at night only, 
7% (6/81) prescribed nocturnal NIV with 65% (53/81) breathing independently. 
Thus, when taking the entire cohort, 63% (53/81) achieved complete 
Ventilatory liberation, 12% (10/81) weaned to nocturnal tracheostomy 
ventilation only and 6% (5/81) were weaned to NIV whilst no further weaning 
was possible in 16% (13/81). The ability to breathe independently by 
discharge was found to correlate with level of injury on admission (CC 0.39; 
p<0.001), level of injury on discharge (CC 0.47; p<0.001) and 
non-significant trend with improvement in neurological function during 
admission (CC 0.21; p=0.06) but not age or gender. Conclusion Our data 
demonstrates that in a cohort of consecutive SCI patients requiring 
mechanical ventilation on admission to a regional Spinal injuries unit, 
weaning from mechanical ventilation was possible in 84% of subjects with 63% 
being liberated completely from Ventilatory support by discharge. The use of 
NIV in the SCI cohort appears to be an emergent strategy during the weaning 
process.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia; spinal cord injury; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; cohort analysis; female; gender; human; major clinical study; male; middle aged; nervous system function; night; phrenic nerve; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619738752
DOI
  10.1136/thoraxjnl-2017-210983.268
FULL TEXT LINK
  http://dx.doi.org/10.1136/thoraxjnl-2017-210983.268
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14683296&id=doi:10.1136%2Fthoraxjnl-2017-210983.268&atitle=Weaning+outcomes+of+mechanically+ventilated+spinal+cord+injured+persons+with+acute+tetraplegia+admitted+to+a+regional+UK+centre+over+a+10+year+period&stitle=Thorax&title=Thorax&volume=72&issue=&spage=A151&epage=&aulast=Chakrabarti&aufirst=B.&auinit=B.&aufull=Chakrabarti+B.&coden=&isbn=&pages=A151-&date=2017&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 148
TITLE
  Spinal cord stimulation for pain treatment failed to modify disease 
progression in a patient with amyotrophic lateral sclerosis
AUTHOR NAMES
  Di Lazzaro V.; Mazzone P.; Insola A.; Florio L.; Capone F.; Ranieri F.
AUTHOR ADDRESSES
  (Di Lazzaro V., v.dilazzaro@unicampus.it; Florio L.; Capone F.; Ranieri F.) 
Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, 
Università Campus Bio-Medico di Roma, via Álvaro del Portillo 21, Rome, 
Italy.
(Di Lazzaro V., v.dilazzaro@unicampus.it; Florio L.; Capone F.; Ranieri F.) 
Fondazione Alberto Sordi – Research Institute for Ageing, Rome, Italy.
(Mazzone P.) Neurosurgery, ASLRMC – CTO Hospital, Rome, Italy.
(Insola A.) Neurophysiology, ASLRMC – CTO Hospital, Rome, Italy.
CORRESPONDENCE ADDRESS
  V. Di Lazzaro, Istituto di Neurologia, Università Campus Bio-Medico, Via 
Alvaro del Portillo 200, Rome, Italy. Email: v.dilazzaro@unicampus.it
AiP/IP ENTRY DATE
  2017-11-02
FULL RECORD ENTRY DATE
  2017-11-08
SOURCE
  Clinical Neurology and Neurosurgery (2017) 163 (108-109). Date of 
Publication: 1 Dec 2017
VOLUME
  163
FIRST PAGE
  108
LAST PAGE
  109
DATE OF PUBLICATION
  1 Dec 2017
ISSN
  1872-6968 (electronic)
  0303-8467
BOOK PUBLISHER
  Elsevier B.V.
EMTREE DRUG INDEX TERMS
  riluzole (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (drug therapy, therapy); analgesia; spinal cord stimulation; 
EMTREE MEDICAL INDEX TERMS
  aged; article; atrophy; Babinski reflex; case report; clinical article; cortical excitability; denervation; disease course; dysarthria; enteric feeding; fasciculation; human; implantable pulse generator; implanted spinal cord stimulator; limb weakness; male; neurophysiology; nuclear magnetic resonance imaging; paresthesia; spastic paraplegia; tracheostomy; 
DEVICE TRADE NAMES
  Octrode
DEVICE MANUFACTURERS
   (United States)St Jude
CAS REGISTRY NUMBERS
  riluzole (1744-22-5)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170757368
MEDLINE PMID
  29096137 (http://www.ncbi.nlm.nih.gov/pubmed/29096137)
PUI
  L618950256
DOI
  10.1016/j.clineuro.2017.10.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clineuro.2017.10.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18726968&id=doi:10.1016%2Fj.clineuro.2017.10.010&atitle=Spinal+cord+stimulation+for+pain+treatment+failed+to+modify+disease+progression+in+a+patient+with+amyotrophic+lateral+sclerosis&stitle=Clin.+Neurol.+Neurosurg.&title=Clinical+Neurology+and+Neurosurgery&volume=163&issue=&spage=108&epage=109&aulast=Di+Lazzaro&aufirst=Vincenzo&auinit=V.&aufull=Di+Lazzaro+V.&coden=CNNSB&isbn=&pages=108-109&date=2017&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 149
TITLE
  Spinal intramedullary tuberculoma following pulmonary tuberculosis: A case 
report and literature review
AUTHOR NAMES
  Wang G.-C.; Wu S.-W.
AUTHOR ADDRESSES
  (Wang G.-C.; Wu S.-W., B8801006@gmail.com) Department of Neurosurgery, 
Neuro-Medical Scientific Center, Buddhist Tzu Chi General Hospital, 707, 
Section 3, Chung Yang Road, Hualien, Taiwan.
CORRESPONDENCE ADDRESS
  S.-W. Wu, Department of Neurosurgery, Neuro-Medical Scientific Center, 
Buddhist Tzu Chi General Hospital, 707, Section 3, Chung Yang Road, Hualien, 
Taiwan. Email: B8801006@gmail.com
AiP/IP ENTRY DATE
  2018-01-04
FULL RECORD ENTRY DATE
  2018-01-09
SOURCE
  Medicine (United States) (2017) 96:49 Article Number: e8673. Date of 
Publication: 1 Dec 2017
VOLUME
  96
ISSUE
  49
DATE OF PUBLICATION
  1 Dec 2017
ISSN
  1536-5964 (electronic)
  0025-7974
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Rationale: Spinal intramedullary tuberculoma (IMTB) is a rare disease that 
accounts for 1 to 2/100,000 patients with tuberculosis. We presented a case 
with pulmonary tuberculosis and concurrent IMTB at C3 to C5 level and 
reviewed the recent case series and discussed the diagnosis, treatment, and 
outcome. Patient concerns: A 33-year-old male had concurrent pulmonary TB 
and IMTB at the C3 to C5 level. He had quadriplegia (muscle power 0 at 4 
limbs) and sensory loss below C5 level. He also had incontinence, anal tone 
loss, and paradoxical respiratory pattern. Diagnosis: Spinal magnetic 
resonance imaging (MRI) showed a 25 11mm intramedullary lesion at C3/C4 
level. Under the impression of IMTB, he underwent surgery. Intervention: We 
performed C3 to C5 laminectomy and en bloc removal of the tumor. The patient 
kept receiving anti-TB medications after the surgery. Outcome: His 4 limbs 
muscle power had improved but could not be liberated from the endotracheal 
tube, so tracheostomy was performed. Muscle power gradually increased to 3 
points in his upper limbs and to 2 points in his lower limbs. Sensation in 
his 4 limbs gradually improved as well. Lessons: IMTB is a rare disease that 
should be treated with a combination of medication and surgery. For patients 
with prominent spinal cord compression and neurological symptoms, early 
operation to remove the tumor is necessary.
EMTREE DRUG INDEX TERMS
  betamethasone; tuberculostatic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lung tuberculosis (drug therapy, diagnosis, drug therapy, surgery); spinal intramedullary tuberculoma (complication, diagnosis, surgery); tuberculoma (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; alcohol liver cirrhosis; cancer surgery; case report; clinical article; computer assisted tomography; drug withdrawal; feces incontinence; human; laminectomy; limb weakness; male; nuclear magnetic resonance imaging; paresthesia; priority journal; quadriplegia; review; X ray; 
CAS REGISTRY NUMBERS
  betamethasone (378-44-9)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180002725
MEDLINE PMID
  29245227 (http://www.ncbi.nlm.nih.gov/pubmed/29245227)
PUI
  L620017029
DOI
  10.1097/MD.0000000000008673
FULL TEXT LINK
  http://dx.doi.org/10.1097/MD.0000000000008673
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15365964&id=doi:10.1097%2FMD.0000000000008673&atitle=Spinal+intramedullary+tuberculoma+following+pulmonary+tuberculosis%3A+A+case+report+and+literature+review&stitle=Medicine&title=Medicine+%28United+States%29&volume=96&issue=49&spage=&epage=&aulast=Wang&aufirst=Guan-Chyuan&auinit=G.-C.&aufull=Wang+G.-C.&coden=MEDIA&isbn=&pages=-&date=2017&auinit1=G&auinitm=-C
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 150
TITLE
  Another cause of CNS hypomyelination-FIG4 mutations
AUTHOR NAMES
  Hussain S.; Berry I.; Soulioti A.; Uka S.; Livingston J.H.; Vadlamani G.
AUTHOR ADDRESSES
  (Hussain S.; Livingston J.H.; Vadlamani G.) Dept. of Paediatric Neurology, 
Leeds General Infirmary, Leeds, United Kingdom.
(Uka S.) Dept. of Paediatrics, Calderdale Hospital, Halifax, United Kingdom.
(Berry I.) Dept. of Genetics, Leeds General Infirmary, United Kingdom.
(Soulioti A.) Dept. of Paediatrics, Dewsbury Hospital, Dewsbury, United 
Kingdom.
CORRESPONDENCE ADDRESS
  S. Hussain, Dept. of Paediatric Neurology, Leeds General Infirmary, Leeds, 
United Kingdom.
FULL RECORD ENTRY DATE
  2018-01-19
SOURCE
  Developmental Medicine and Child Neurology (2017) 59 Supplement 4 (113). 
Date of Publication: 1 Dec 2017
VOLUME
  59
FIRST PAGE
  113
DATE OF PUBLICATION
  1 Dec 2017
CONFERENCE NAME
  44th Annual Conference of the British Paediatric Neurology Association, BPNA 
2018
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2018-01-03 to 2018-01-05
ISSN
  1469-8749
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Introduction: FIG4 mutations are associated with CMT4J, Amyotrophic lateral 
sclerosis-11(ALS11), bilateral polymicro-gyria and Yunis-Varon Syndrome. We 
describe a novel phe-notype manifesting with peripheral neuropathy and CNS 
hypomyelination in 2 cases. Case series: Patient A was born at term to 
consanguineous Asian parents. He had early developmental delay, depressed 
reflexes, poor facial movements and four limb hypotonia. Neurophysiology 
confirmed a demyelinating polyneuropathy. At 11yrs of age he is wheelchair, 
tracheostomy and gastros-tomy dependent. He has profound weakness with 
contrac-tures, communication via eye gaze and gestures. Serial MRI at 
30-months, 7 years and 8-years of age, showed hypomyelina-tion with 
hyperintense T2-signal in the internal capsules, deep white matter and 
cerebellar hypoplasia. Genetic testing by whole exome sequencing confirmed a 
mutation in FIG4. Patient B was born after IVF to unrelated caucasian 
parents. He had global delay with four limb hypotonia and difficult to 
elicit reflexes, suggesting a peripheral neuropathy. He had a squint and 
myopic vision. At around 34 months of age, he walks with his hands held and 
babbles. Serial MRI at 10-months and 27-months showed hypomyelination 
throughout the subcortical white matter with increased T2 signal in the 
internal capsule and cerebellar hypoplasia. Genetic testing confirmed a FIG4 
mutation. Discussion: FIG4 encodes Sac-3 protein, a phosphatase involved in 
vesicle trafficking. In the mouse model of Null-FIG4, hypomyelination of the 
brain and spinal cord occurs in addition to peripheral neuropathy seen in 
humans. Transgenic mice with overexpression of human pathogenic FIG4-141T 
variant have protection from the hypomyelination. To our knowledge, these 
cases are the first evidence of hypomyelina-tion seen in the human phenotype 
of FIG4. Functional studies on fibroblasts are in progress to confirm this 
further.
EMTREE DRUG INDEX TERMS
  endogenous compound; phosphatase; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  capsula interna; mutation; 
EMTREE MEDICAL INDEX TERMS
  animal experiment; animal model; Asian; case study; Caucasian; cerebellum hypoplasia; demyelinating neuropathy; developmental delay; face; fibroblast; gaze; gene overexpression; genetic screening; gesture; human; limb; male; mouse; mouse model; muscle hypotonia; myopia; neurophysiology; nonhuman; nuclear magnetic resonance imaging; peripheral neuropathy; phenotype; reflex; strabismus; tracheostomy; transgenic mouse; vision; weakness; wheelchair; white matter; whole exome sequencing; 
CAS REGISTRY NUMBERS
  phosphatase (9013-05-2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L620214411
DOI
  10.1111/dmcn.13623
FULL TEXT LINK
  http://dx.doi.org/10.1111/dmcn.13623
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14698749&id=doi:10.1111%2Fdmcn.13623&atitle=Another+cause+of+CNS+hypomyelination-FIG4+mutations&stitle=Dev.+Med.+Child+Neurol.&title=Developmental+Medicine+and+Child+Neurology&volume=59&issue=&spage=113&epage=&aulast=Hussain&aufirst=S.&auinit=S.&aufull=Hussain+S.&coden=&isbn=&pages=113-&date=2017&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 151
TITLE
  Transpedicular direct osteosynthesis of hangman's fracture from a mini-open 
exposure as a less invasive procedure: A technical note
AUTHOR NAMES
  Kovari V.Z.; Josvai A.; Csokay A.
AUTHOR ADDRESSES
  (Kovari V.Z., viktor.zs.kovari@gmail.com; Josvai A.; Csokay A.) Hungarian 
Defense Forces Medical Centre, Department of Neurosurgery, 44. Robert Karoly 
krt., Budapest, Hungary.
CORRESPONDENCE ADDRESS
  V.Z. Kovari, Hungarian Defense Forces Medical Centre, Department of 
Neurosurgery, 44. Robert Karoly krt., Budapest, Hungary. Email: 
viktor.zs.kovari@gmail.com
AiP/IP ENTRY DATE
  2017-11-14
FULL RECORD ENTRY DATE
  2017-12-06
SOURCE
  Trauma Case Reports (2017) 12 (66-71). Date of Publication: 1 Dec 2017
VOLUME
  12
FIRST PAGE
  66
LAST PAGE
  71
DATE OF PUBLICATION
  1 Dec 2017
ISSN
  2352-6440 (electronic)
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  This surgical technical case report presents initial clinical experience and 
preliminary results with a less invasive surgical solution for selected 
hangman's fracture. A well-known stabilization technique (i.e. direct 
transpedicular osteosynthesis) was applied through a minimally invasive 
small incision transmuscular posterior approach guided by a standard C-arm 
fluoroscopy. This mini-open approach to C2 vertebra allows similar 
dissection, visualization of the bony landmarks, visual control of the 
transpedicular screw path drilling, tapping and screw insertion to the 
standard posterior cervical spine approach. At the same time it has the 
benefits of less invasive procedures.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fracture (surgery); hangman fracture (surgery); osteosynthesis; spondylolisthesis (surgery); transpedicular direct osteosynthesis; 
EMTREE MEDICAL INDEX TERMS
  adult; article; bleeding (complication); bone screw; case report; clinical article; componet fracture (diagnosis); computer assisted tomography; disease classification; female; fluoroscopy; grip strength; human; Kirschner wire; Levine Edward classification; medical history; neurologic disease; nuclear magnetic resonance imaging; open fracture (surgery); operation duration; pedicle screw; priority journal; retractor; second cervical vertebra; semispinalis capitis muscle; spinal cord compression (diagnosis); spine fracture (diagnosis); spine stabilization; splenius capitis; surgical technique; surgical wire; tracheostomy; traffic accident; trapezius muscle; treatment outcome; zygapophyseal joint; 
DEVICE MANUFACTURERS
  Medtronic Mast Quadrant
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170787182
PUI
  L619159243
DOI
  10.1016/j.tcr.2017.10.025
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.tcr.2017.10.025
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23526440&id=doi:10.1016%2Fj.tcr.2017.10.025&atitle=Transpedicular+direct+osteosynthesis+of+hangman%27s+fracture+from+a+mini-open+exposure+as+a+less+invasive+procedure%3A+A+technical+note&stitle=Trauma+Case+Rep.&title=Trauma+Case+Reports&volume=12&issue=&spage=66&epage=71&aulast=Kovari&aufirst=Viktor+Zsolt&auinit=V.Z.&aufull=Kovari+V.Z.&coden=&isbn=&pages=66-71&date=2017&auinit1=V&auinitm=Z
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 152
TITLE
  Isolated C5 vertebrae dislocation with trauma: An extremely rare case of 
isolated C5 dislocation
AUTHOR NAMES
  Özdoğan S.; Kaya M.; Demirel N.; Düzkalır A.H.; Yaltırık C.K.
AUTHOR ADDRESSES
  (Özdoğan S., drselcukozdogan@hotmail.com; Demirel N.) Department of 
Neurosurgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
(Kaya M.) Department of Neurosurgery, Ereğli State Hospital, Zonguldak, 
Turkey.
(Düzkalır A.H.) Department of Neurosurgery, Dr. Lütfi Kırdar Kartal Training 
and Research Hospital, Istanbul, Turkey.
(Yaltırık C.K.) Department of Neurosurgery, Yeditepe University School of 
Medicine, Istanbul, Turkey.
CORRESPONDENCE ADDRESS
  S. Özdoğan, Department of Neurosurgery, Istanbul Training and Research 
Hospital, Istanbul, Turkey. Email: drselcukozdogan@hotmail.com
AiP/IP ENTRY DATE
  2017-12-15
FULL RECORD ENTRY DATE
  2017-12-20
SOURCE
  American Journal of Case Reports (2017) 18 (1256-1260). Date of Publication: 
28 Nov 2017
VOLUME
  18
FIRST PAGE
  1256
LAST PAGE
  1260
DATE OF PUBLICATION
  28 Nov 2017
ISSN
  1941-5923 (electronic)
BOOK PUBLISHER
  International Scientific Information, Inc., office@isl-science.com
ABSTRACT
  Objective: Rare disease Background: Total spondylolisthesis, or dislocation 
of 1 cervical vertebrae, is only caused by high-energy trauma and is usually 
fatal. Cervical spine fractures and dislocations often cause 3-column 
structural damage to the cervical spine, injury to the spinal cord, and 
precipitating alignment of the cervical vertebrae, as well as cervical 
instability, which are detrimental, show poor prognosis, and are associated 
with high rates of mortality rate and disability. Case Report: We report an 
extremely rare case of isolated C5 dislocation caused by falling out of a 
tree, with sudden tetraplegia. Conclusions: Total spondylolisthesis or 
dislocation of 1 cervical vertebrae can be surgically treated with anterior 
approach because it is possible to completely remove the vertebra body, 
intervertebral disc, and bone fragments, to directly decompress the spinal 
cord with stabilization.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spine injury (diagnosis, surgery, therapy); vertebra dislocation (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; artery injury (diagnosis); article; artificial ventilation; bone graft; case report; clinical article; computed tomographic angiography; computer assisted tomography; dissector; emergency health service; falling; female; fracture fixation; human; intensive care unit; liquorrhea (diagnosis); neurologic examination; nuclear magnetic resonance imaging; plate fixation; positive end expiratory pressure; postoperative period; quadriplegia (diagnosis); spinal hematoma (diagnosis, therapy); tracheostomy; urinary catheter; urine incontinence (diagnosis, therapy); ventilator; vertebral artery; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Urology and Nephrology (28)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170867993
MEDLINE PMID
  29180614 (http://www.ncbi.nlm.nih.gov/pubmed/29180614)
PUI
  L619534764
DOI
  10.12659/AJCR.907396
FULL TEXT LINK
  http://dx.doi.org/10.12659/AJCR.907396
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19415923&id=doi:10.12659%2FAJCR.907396&atitle=Isolated+C5+vertebrae+dislocation+with+trauma%3A+An+extremely+rare+case+of+isolated+C5+dislocation&stitle=Am.+J.+Case+Rep.&title=American+Journal+of+Case+Reports&volume=18&issue=&spage=1256&epage=1260&aulast=%C3%96zdo%C4%9Fan&aufirst=Sel%C3%A7uk&auinit=S.&aufull=%C3%96zdo%C4%9Fan+S.&coden=&isbn=&pages=1256-1260&date=2017&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 153
TITLE
  Transoral robotic-assisted surgery for the approach to anterior cervical 
spine lesions
AUTHOR NAMES
  Molteni G.; Greco M.G.; Presutti L.
AUTHOR ADDRESSES
  (Molteni G., gabbomolteni@gmail.com) Department of Otolaryngology-Head and 
Neck Surgery, University Hospital of Verona, Verona, Italy.
(Greco M.G.; Presutti L.) Department of Otolaryngology-Head and Neck 
Surgery, University Hospital Policlinico di Modena, Modena, Italy.
CORRESPONDENCE ADDRESS
  G. Molteni, Department of Otolaryngology-Head and Neck Surgery, University 
Hospital of Verona, Verona, Italy. Email: gabbomolteni@gmail.com
AiP/IP ENTRY DATE
  2017-09-12
FULL RECORD ENTRY DATE
  2017-10-23
SOURCE
  European Archives of Oto-Rhino-Laryngology (2017) 274:11 (4011-4016). Date 
of Publication: 1 Nov 2017
VOLUME
  274
ISSUE
  11
FIRST PAGE
  4011
LAST PAGE
  4016
DATE OF PUBLICATION
  1 Nov 2017
ISSN
  1434-4726 (electronic)
  0937-4477
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  The Da Vinci robotic surgical system is increasingly being used by head and 
neck surgeons in transoral approaches for head and neck cancer. Our 
experience using the Da Vinci system for transoral robotic-assisted surgery 
(TORS) is presented. The feasibility of TORS for lesions involving the 
anterior portion of C1–C2 and the cranio-cervical junction has been 
evaluated from an anatomical viewpoint in a cadaveric laboratory. Two 
patients treated using the Da Vinci system to reach C1–C2 benign lesions are 
presented. The anatomical cadaveric study showed that this approach is safe 
and feasible. The first two cases which we describe confirmed the advantages 
of the Da Vinci system in the anterior approach to the cervical spine and 
allowed the limitations of this procedure to be assessed. TORS may be useful 
to reach anterior lesions of the cervical spine localized at the level of C1 
and C2: first, for removal of small benign and well-delineated lesions; and 
second, for diagnostic purposes with biopsy of large lesions. Further 
studies and new instruments are needed to confirm the safety and results of 
this approach in terms of morbidity.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; robot assisted surgery; spine disease (surgery); surgical approach; transoral robotic assisted surgery; 
EMTREE MEDICAL INDEX TERMS
  absorbable barbed suture; aged; antibiotic therapy; article; atlantooccipital joint; barbed suture; bone drill; cadaver; case report; cervical spine radiography; clinical article; computer assisted tomography; Da Vinci; diarrhea; feasibility study; female; fibrocartilage; forceps; histopathology; human; human tissue; laparoscopic surgical instrument; laparoscopic video camera; limb weakness; nasogastric tube; neuroimaging; nuclear magnetic resonance imaging; operation duration; osteodystrophy (diagnosis); paresthesia; postoperative infection (complication); priority journal; silastic tube; spinal cord decompression; surgical technique; tracheotomy; tube removal; vomiting; 
DEVICE TRADE NAMES
  Da Vinci
  V-loc
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170629165
MEDLINE PMID
  28864959 (http://www.ncbi.nlm.nih.gov/pubmed/28864959)
PUI
  L618171791
DOI
  10.1007/s00405-017-4731-4
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00405-017-4731-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14344726&id=doi:10.1007%2Fs00405-017-4731-4&atitle=Transoral+robotic-assisted+surgery+for+the+approach+to+anterior+cervical+spine+lesions&stitle=Eur.+Arch.+Oto-Rhino-Laryngol.&title=European+Archives+of+Oto-Rhino-Laryngology&volume=274&issue=11&spage=4011&epage=4016&aulast=Molteni&aufirst=Gabriele&auinit=G.&aufull=Molteni+G.&coden=EAOTE&isbn=&pages=4011-4016&date=2017&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 154
TITLE
  Spinal muscular atrophy carriers with two SMN1 copies
AUTHOR NAMES
  Ar Rochmah M.; Awano H.; Awaya T.; Harahap N.I.F.; Morisada N.; Bouike Y.; Saito T.; Kubo Y.; Saito K.; Lai P.S.; Morioka I.; Iijima K.; Nishio H.; Shinohara M.
AUTHOR ADDRESSES
  (Ar Rochmah M.; Harahap N.I.F.; Nishio H., nishio@med.kobe-u.ac.jp; 
Shinohara M.) Department of Community Medicine and Social Healthcare 
Science, Kobe University Graduate School of Medicine, Kobe, Japan.
(Awano H.; Morisada N.; Morioka I.; Iijima K.; Nishio H., 
nishio@med.kobe-u.ac.jp) Department of Pediatrics, Kobe University Graduate 
School of Medicine, Kobe, Japan.
(Awaya T.) Department of Pediatrics, Kyoto University Graduate School of 
Medicine, Kyoto, Japan.
(Morisada N.) Department of Clinical Genetics, Hyogo Prefectural Kobe 
Children's Hospital, Kobe, Japan.
(Bouike Y.) Faculty of Nutrition, Kobe Gakuin University, Kobe, Japan.
(Saito T.) Division of Child Neurology, Department of Neurology, National 
Hospital Organization Toneyama National Hospital, Toyonaka, Japan.
(Kubo Y.; Saito K.) Institute of Medical Genetics, Tokyo Women's Medical 
University, Tokyo, Japan.
(Lai P.S.) Department of Paediatrics, Yong Loo Lin School of Medicine, 
National University of Singapore, Singapore.
CORRESPONDENCE ADDRESS
  H. Nishio, Department of Community Medicine and Social Healthcare Science, 
Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, 
Kobe, Japan. Email: nishio@med.kobe-u.ac.jp
AiP/IP ENTRY DATE
  2017-07-05
FULL RECORD ENTRY DATE
  2018-05-29
SOURCE
  Brain and Development (2017) 39:10 (851-860). Date of Publication: 1 Nov 
2017
VOLUME
  39
ISSUE
  10
FIRST PAGE
  851
LAST PAGE
  860
DATE OF PUBLICATION
  1 Nov 2017
ISSN
  1872-7131 (electronic)
  0387-7604
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  Background Spinal muscular atrophy (SMA) is an autosomal recessive 
neuromuscular disorder. Over 95% of SMA patients have homozygous deletions 
of the SMA-causative gene, SMN1. Thus, SMA carriers are usually diagnosed 
based on SMN1 copy number, with one copy indicating SMA carrier status. 
However, two SMN1 copies do not always exclude carrier status. In this 
study, we identified SMA carriers with two SMN1 copies. Subjects and methods 
From 33 families, 65 parents of genetically confirmed SMA patients were 
tested to determine SMA carrier status. Molecular genetic analyses, 
including multiplex ligation-dependent probe amplification (MLPA) assay, 
were performed using blood samples from family members. Results Of the 65 
parents, three parents from three families had two SMN1 copies. Accordingly, 
the frequency of carriers with two SMN1 copies was 4.6%. Two of these 
families were further studied. Patient 1 was homozygous for SMN1 deletion. 
Patient 1's mother had two SMN1 copies on one chromosome, with deletion of 
SMN1 on the other chromosome ([2 + 0] genotype). Patient 1 inherited 
SMN1-deleted chromosomes from both parents. Patient 2 was compound 
heterozygous for two SMN1 mutations: whole-gene deletion and intragenic 
missense mutation, c.826T > C (p.Tyr276His). Patient 2's father had two SMN1 
copies with the same intragenic mutation in one copy ([1 + 1(d)] genotype, 
(d) intragenic mutation). Patient 2 inherited the chromosome with an SMN1 
mutation from the father and SMN1-deleted chromosome from the mother. 
Conclusion SMA carriers with two SMN1 copies may be rare, but its 
possibility should be taken into consideration in carrier testing and 
counseling for SMA families or population-based carrier screening.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  survival motor neuron protein 1 (endogenous compound); 
EMTREE DRUG INDEX TERMS
  genomic DNA (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  agar gel electrophoresis; allele; Apgar score; article; assisted ventilation; birth weight; bradycardia; chromosome deletion; disease course; female; gene amplification; gene conversion; gene deletion; gene mutation; genetic analysis; heterozygosity; human; infant; major clinical study; missense mutation; multiplex ligation dependent probe amplification; muscle hypotonia; nucleotide sequence; pneumonia; point mutation; polymerase chain reaction; real time polymerase chain reaction; respiratory failure; restriction fragment length polymorphism; tracheotomy; 
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170467969
MEDLINE PMID
  28676237 (http://www.ncbi.nlm.nih.gov/pubmed/28676237)
PUI
  L617046452
DOI
  10.1016/j.braindev.2017.06.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.braindev.2017.06.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18727131&id=doi:10.1016%2Fj.braindev.2017.06.002&atitle=Spinal+muscular+atrophy+carriers+with+two+SMN1+copies&stitle=Brain+Dev.&title=Brain+and+Development&volume=39&issue=10&spage=851&epage=860&aulast=Ar+Rochmah&aufirst=Mawaddah&auinit=M.&aufull=Ar+Rochmah+M.&coden=BDEVD&isbn=&pages=851-860&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 155
TITLE
  One-year outcomes following treatment with nusinersen: Interim results from 
the NURTURE study of presymptomatic infants with genetically diagnosed 
spinal muscular atrophy (SMA)
AUTHOR NAMES
  De Vivo D.; Bertini E.; Hwu W.-L.; Foster R.; Gheuens S.; Farwell W.; Reyna S.
AUTHOR ADDRESSES
  (De Vivo D.; Bertini E.; Hwu W.-L.; Foster R.; Gheuens S.; Farwell W.; Reyna 
S.) New York, United States.
CORRESPONDENCE ADDRESS
  D. De Vivo, New York, United States.
FULL RECORD ENTRY DATE
  2018-06-06
SOURCE
  Annals of Neurology (2017) 82 Supplement 21 (S265-S266). Date of 
Publication: 1 Oct 2017
VOLUME
  82
FIRST PAGE
  S265
LAST PAGE
  S266
DATE OF PUBLICATION
  1 Oct 2017
CONFERENCE NAME
  46th Annual Meeting of the Child Neurology Society
CONFERENCE LOCATION
  Kansas City, MO, United States
CONFERENCE DATE
  2017-10-04 to 2017-10-07
ISSN
  1531-8249
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Objective: NURTURE is an ongoing phase 2, open-label, single-arm study, 
evaluating intrathecal nusinersen (12-mg equivalent dose) in infants with 
presymptomatic SMA. Methods: Enrolled infants were presymptomatic at 
screening, age ≤6 weeks at first dose, had genetic diagnosis of SMA, and 2 
or 3 SMN2 copies. The primary endpoint is time to death or respiratory 
intervention (tracheostomy/ventilation for ≥6 hours/day for ≥7 days). 
Secondary end-points include: proportion of infants developing protocol- 
(Table Presented) defined SMA symptoms (defined by age-adjusted weight, 
g-tube placement or failure to achieve appropriate WHO motor milestones), 
motor milestone attainment assessed by Hammersmith Infant Neurological 
Examination (HINE) Section 2 and change in Children's Hospital of 
Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) scale. 
Outcomes for infants completing Day365 visit are reported. Results: As of 31 
Oct 2016, 20 infants have enrolled; 9 have completed Day365. After 1 year, 
no infants died or required respiratory intervention. All infants (9/9) 
achieved expected HINE motor milestones for healthy infants based on age in 
the categories ability to kick and head control, 7/9 achieved rolling, 6/9 
sitting, 5/9 crawling, 5/9 walking, and 3/9 standing (Table). Three infants 
achieved all HINE motor milestones expected for age. Median total CHOP 
INTEND score was 62.0 (range:44-64) points at Day365. Four infants (all 2 
SMN2 copies) exhibited protocol-defined SMA symptoms at Day365, 1 lost 
weight between Day184-365; however, all 4 were sitting without support. 
Conclusions: These results suggest that early intervention with nusinersen, 
before symptom onset, provides clinical benefits in infants with genetically 
diagnosed SMA.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE DRUG INDEX TERMS
  endogenous compound; survival motor neuron protein 2; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neurology; spinal muscular atrophy type 2; 
EMTREE MEDICAL INDEX TERMS
  child; clinical article; conference abstract; controlled study; death; diagnosis; drug therapy; early intervention; female; head; human; infant; male; mental capacity; neurologic examination; Pennsylvania; tracheostomy; walking; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622416208
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15318249&id=doi:&atitle=One-year+outcomes+following+treatment+with+nusinersen%3A+Interim+results+from+the+NURTURE+study+of+presymptomatic+infants+with+genetically+diagnosed+spinal+muscular+atrophy+%28SMA%29&stitle=Ann.+Neurol.&title=Annals+of+Neurology&volume=82&issue=&spage=S265&epage=S266&aulast=De+Vivo&aufirst=D.&auinit=D.&aufull=De+Vivo+D.&coden=&isbn=&pages=S265-S266&date=2017&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 156
TITLE
  Analysis of a series of patients with acute flaccid myelitis (AFM) 
Presenting to a Tertiary Care Referral Center
AUTHOR NAMES
  Kuwabara N.; Shah S.; Igarashi M.; Jack R.; Karmarkar S.; Caron E.; Bhattarai P.; Shah N.
AUTHOR ADDRESSES
  (Kuwabara N.; Shah S.; Igarashi M.; Jack R.; Karmarkar S.; Caron E.; 
Bhattarai P.; Shah N.) Memphis, United States.
CORRESPONDENCE ADDRESS
  N. Kuwabara, Memphis, United States.
FULL RECORD ENTRY DATE
  2018-06-06
SOURCE
  Annals of Neurology (2017) 82 Supplement 21 (S274). Date of Publication: 1 
Oct 2017
VOLUME
  82
FIRST PAGE
  S274
DATE OF PUBLICATION
  1 Oct 2017
CONFERENCE NAME
  46th Annual Meeting of the Child Neurology Society
CONFERENCE LOCATION
  Kansas City, MO, United States
CONFERENCE DATE
  2017-10-04 to 2017-10-07
ISSN
  1531-8249
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Objective: Acute Flaccid Myelitis (AFM) affects the spinal cord leading to 
serious flaccid neurologic sequelae. While Enterovirus D68 (EVD68) 
infections are commonly implicated, its overall management options are 
poorly described. We present the analysis of a series of children with AFM 
presenting to a mid-south tertiary care referral center. Methods: 
Retrospective chart review of six cases of AFM admitted from January 2016 to 
December 2016. Results: In our series only boys were affected; 50% were less 
than 6 years, with a mean age of 7.4 years. The peak incidence corresponds 
to CDC reports in September 2016. Clinical and/or radiographic abnormalities 
in the brainstem were present in 67% patients with 50% patients requiring 
mechanical ventilatory support. 67% patients could not ambulate at 
admission. A gastrostomy tube and tracheostomy was required in 33% patients. 
MRI abnormalities were predominantly noted in the cervical spinal cord in 
83% patients. Peripheral nerve enhancement was determined in 33% patients. 
CSF pleocytosis was seen in 66%. Only two patients tested positive for EVD68 
by nasopharyngeal PCR. All patients had residual neurological deficits at 
discharge despite immunomodulatory treatments including steroid, intravenous 
gamma globulin, plasma exchange. Four patients required further inpatient 
rehabilitation. Conclusions: This AFM case series demonstrates variable 
clinical presentations with brainstem and peripheral nerve involvement with 
residual neurological deficits. The role of immunomodulatory therapy in AFM 
requires further investigation. We recommend early recognition and prompt 
neuro-rehabilitation for patients with AFM to improve their long-term 
outcomes.
EMTREE DRUG INDEX TERMS
  human immunoglobulin; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  infection; myelitis; neuroimaging; neuroimmunology; patient referral; tertiary health care; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; brain stem; case report; case study; cervical spinal cord; child; clinical article; conference abstract; congenital malformation; drug therapy; Enterovirus D68; hospital patient; human; incidence; male; medical record review; nasopharynx; neurorehabilitation; nonhuman; nuclear magnetic resonance imaging; peripheral nerve; plasma exchange; pleocytosis; polymerase chain reaction; rehabilitation; retrospective study; school child; stomach tube; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L622416293
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15318249&id=doi:&atitle=Analysis+of+a+series+of+patients+with+acute+flaccid+myelitis+%28AFM%29+Presenting+to+a+Tertiary+Care+Referral+Center&stitle=Ann.+Neurol.&title=Annals+of+Neurology&volume=82&issue=&spage=S274&epage=&aulast=Kuwabara&aufirst=N.&auinit=N.&aufull=Kuwabara+N.&coden=&isbn=&pages=S274-&date=2017&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 157
TITLE
  The Experience of Families with Children with Spinal Muscular Atrophy Type i 
Across Health Care Systems
AUTHOR NAMES
  Murrell D.V.; Lotze T.E.; Farber H.J.; Crawford C.A.; Wiemann C.M.
AUTHOR ADDRESSES
  (Murrell D.V., dvmurrel@texaschildrens.org) Section of Neurology, Texas 
Children's Hospital, 6701 Fannin St, Houston, United States.
(Lotze T.E.) Section of Neurology, Department of Pediatrics, Baylor College 
of Medicine, Texas Children's Hospital, Houston, United States.
(Farber H.J.) Section of Pulmonology, Department of Pediatrics, Baylor 
College of Medicine, Texas Children's Hospital, Houston, United States.
(Crawford C.A.) Texas Children's Hospital, Houston, United States.
(Wiemann C.M.) Section of Adolescent Medicine and Sports Medicine, 
Department of Pediatrics, Baylor College of Medicine, Texas Children's 
Hospital, Houston, United States.
CORRESPONDENCE ADDRESS
  D.V. Murrell, Section of Neurology, Texas Children's Hospital, 6701 Fannin 
St, Houston, United States. Email: dvmurrel@texaschildrens.org
AiP/IP ENTRY DATE
  2017-09-15
FULL RECORD ENTRY DATE
  2017-09-18
SOURCE
  Journal of Child Neurology (2017) 32:11 (917-923). Date of Publication: 1 
Oct 2017
VOLUME
  32
ISSUE
  11
FIRST PAGE
  917
LAST PAGE
  923
DATE OF PUBLICATION
  1 Oct 2017
ISSN
  1708-8283 (electronic)
  0883-0738
BOOK PUBLISHER
  SAGE Publications Inc., claims@sagepub.com
ABSTRACT
  Spinal muscular atrophy type I is a genetic disease characterized by 
degeneration of spinal cord motor neurons resulting in weakness, technology 
dependence and early demise. While the newly approved treatment nusinersen 
may alter the morbidity/mortality of this disease there continues to be 
complex treatment challenges to consider. The aim of this qualitative study 
was to understand from the parent's perspective, experiences of the family 
and child in the emergency center, hospital, and clinical care settings to 
identify gaps in care. Nineteen families interviewed had 22 children with 
spinal muscular atrophy I (11 deceased, 11 living). Three overarching themes 
emerged from parent interviews describing a range of experiences surrounding 
diagnosis, informed medical decision making and acute care practice. 
Identified quality improvements include development of a diagnostic 
screening tool, a medical decision tool, and emergency center informational 
template individualized to the child and providing an overview of spinal 
muscular atrophy I.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; bulbar paralysis; child; child experience; child parent relation; controlled study; environment; experience; family counseling; family experience; female; health care personnel; health care system; human; infant; long term care; male; medical decision making; palliative therapy; priority journal; quality of life; respiratory distress; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
EMBASE CLASSIFICATIONS
  Health Policy, Economics and Management (36)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170641789
MEDLINE PMID
  28671037 (http://www.ncbi.nlm.nih.gov/pubmed/28671037)
PUI
  L618240159
DOI
  10.1177/0883073817716853
FULL TEXT LINK
  http://dx.doi.org/10.1177/0883073817716853
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17088283&id=doi:10.1177%2F0883073817716853&atitle=The+Experience+of+Families+with+Children+with+Spinal+Muscular+Atrophy+Type+i+Across+Health+Care+Systems&stitle=J.+Child+Neurol.&title=Journal+of+Child+Neurology&volume=32&issue=11&spage=917&epage=923&aulast=Murrell&aufirst=Diane+V.&auinit=D.V.&aufull=Murrell+D.V.&coden=JOCNE&isbn=&pages=917-923&date=2017&auinit1=D&auinitm=V
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 158
TITLE
  Risk factors for severe dysphagia in acute cervical spinal cord injury
AUTHOR NAMES
  Hayashi T.; Fujiwara Y.; Sakai H.; Maeda T.; Ueta T.; Shiba K.
AUTHOR ADDRESSES
  (Hayashi T., tetsuo884hayashi@yahoo.co.jp; Sakai H.; Maeda T.; Ueta T.; 
Shiba K.) Department of Orthopaedic Surgery, Japan Organization of 
Occupational Health and Safety, Spinal Injuries Center, 550-4 Igisu, Iizuka 
city, Fukuoka, Japan.
(Fujiwara Y.) Department of Nursing, Japan Organization of Occupational 
Health and Safety, Spinal Injuries Center, Fukuoka, Japan.
CORRESPONDENCE ADDRESS
  T. Hayashi, Department of Orthopaedic Surgery, Japan Organization of 
Occupational Health and Safety, Spinal Injuries Center, 550-4 Igisu, Iizuka 
city, Fukuoka, Japan. Email: tetsuo884hayashi@yahoo.co.jp
AiP/IP ENTRY DATE
  2017-10-13
FULL RECORD ENTRY DATE
  2017-10-18
SOURCE
  Spinal Cord (2017) 55:10 (940-943). Date of Publication: 1 Oct 2017
VOLUME
  55
ISSUE
  10
FIRST PAGE
  940
LAST PAGE
  943
DATE OF PUBLICATION
  1 Oct 2017
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design:A retrospective, consecutive case series.Objectives:The 
relationship between dysphagia and acute cervical spinal cord injury (CSCI) 
has been recently reported; however, the cause and mechanism of dysphagia 
are still not well understood. No definitive factors have yet been 
established according to multivariate analysis. The objective is to 
elucidate the incidence and risk factors of dysphagia in patients with acute 
CSCI.Setting:Spinal Injuries Center, Fukuoka, Japan.Methods:A total of 298 
patients with acute CSCI, who were evaluated for neurological impairment 
within 3 days after injury, were reviewed. CSCI patients with tube 
dependence due to obvious aspiration after injury were defined as having 
dysphagia. The factors postulated to increase the risk for dysphagia, 
including the patient's age, sex, American Spinal Injury Association (ASIA) 
impairment scale at 3 days after injury, level of injury, tracheostomy and 
operative treatment, were analyzed using a multiple logistic regression 
model.Results:Of 298 patients, 21 were suffering from severe dysphagia after 
acute CSCI (7.0%). Of these 21 patients, 12 (57%) had CSCI at the C3-C4 
level. Multivariable logistic regression analysis revealed that old age (>72 
years), severe ASIA impairment scale (A or B) and presence of tracheostomy 
were significant risk factors of dysphagia. Level of injury ≥C3-C4 was not a 
significant risk factor after adjustment for several potential 
confounders.Conclusion:The incidence of severe dysphagia associated with 
aspiration was 7%. Old age, severe paralysis and presence of tracheostomy 
may be the risk factors for dysphagia. The risk for dysphagia should be 
evaluated to prevent aspiration pneumonia.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; dysphagia; risk factor; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; American Spinal Injury Association impairment scale; article; case study; female; human; Japan; major clinical study; male; priority journal; retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170708965
MEDLINE PMID
  28555661 (http://www.ncbi.nlm.nih.gov/pubmed/28555661)
PUI
  L618680583
DOI
  10.1038/sc.2017.63
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2017.63
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fsc.2017.63&atitle=Risk+factors+for+severe+dysphagia+in+acute+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=55&issue=10&spage=940&epage=943&aulast=Hayashi&aufirst=T.&auinit=T.&aufull=Hayashi+T.&coden=SPCOF&isbn=&pages=940-943&date=2017&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 159
TITLE
  Variation in definition of prolonged mechanical ventilation
AUTHOR NAMES
  Rose L.; McGinlay M.; Amin R.; Burns K.E.; Connolly B.; Hart N.; Jouvet P.; Katz S.; Leasa D.; Mawdsley C.; McAuley D.F.; Schultz M.J.; Blackwood B.
AUTHOR ADDRESSES
  (Rose L., louise.rose@utoronto.ca) Department of Critical Care Medicine, 
Sunnybrook Health Sciences Centre, The Lawrence S Bloomberg, Faculty of 
Nursing and the Interdepartmental Division of Critical Care Medicine, 
University of Toronto, Provincial Centre of Weaning Excellence, Toronto East 
General Hospital, Toronto, Canada.
(McGinlay M.) Royal Victoria Hospital, Belfast, United Kingdom.
(Amin R.) SickKids Hospital and the Division of Respirology, University of 
Toronto, Toronto, Canada.
(Burns K.E.) Saint Michael’s Hospital, the Li Ka Shing Knowledge Institute, 
Interdepartmental Division of Critical Care Medicine, University of Toronto, 
Toronto, Canada.
(Connolly B.) Lane Fox Respiratory Unit, St Thomas’s Hospital, Guy’s and St 
Thomas’s NHS Foundation Trust, London, United Kingdom.
(Hart N.) Lane Fox Respiratory Unit, St Thomas’s Hospital, Guy’s and St 
Thomas’s NHS Foundation Trust, King’s College London, London, United 
Kingdom.
(Jouvet P.) Pediatric Intensive Care Unit, Department of Pediatrics, 
Sainte-Justine Hospital, University of Montreal, Montreal, Canada.
(Katz S.) Department of Respirology, Children’s Hospital of Eastern Ontario, 
CHEO Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, 
Canada.
(Leasa D.) Critical Care Western and London Health Sciences Centre and 
Western University, Ottawa, Canada.
(Mawdsley C.) Critical Care Western and London Health Sciences Centre, 
London, Canada.
(McAuley D.F.) Royal Victoria Hospital and the Centre for Experimental 
Medicine, Queen’s University, Belfast, United Kingdom.
(Schultz M.J.) Laboratory of Experimental Intensive Care and Anesthesiology, 
Academic Medical Center, University of Amsterdam, Amsterdam-Zuidoost, 
Netherlands.
(Blackwood B.) Centre for Experimental Medicine, Queen’s University, 
Belfast, United Kingdom.
CORRESPONDENCE ADDRESS
  L. Rose, Faculty of Nursing, University of Toronto, 155 College Street, 
Toronto, Canada. Email: louise.rose@utoronto.ca
AiP/IP ENTRY DATE
  2018-10-03
FULL RECORD ENTRY DATE
  2018-10-08
SOURCE
  Respiratory Care (2017) 62:10 (1324-1332). Date of Publication: 1 Oct 2017
VOLUME
  62
ISSUE
  10
FIRST PAGE
  1324
LAST PAGE
  1332
DATE OF PUBLICATION
  1 Oct 2017
ISSN
  1943-3654 (electronic)
  0020-1324
BOOK PUBLISHER
  American Association for Respiratory Care
ABSTRACT
  Consistency of definitional criteria for terminology applied to describe 
subject cohorts receiving mechanical ventilation within ICU and post-acute 
care settings is important for understanding prevalence, risk 
stratification, effectiveness of interventions, and projections for resource 
allocation. Our objective was to quantify the application and definition of 
terms for prolonged mechanical ventilation. We conducted a scoping review of 
studies (all designs except single-case study) reporting a study population 
(adult and pediatric) using the term prolonged mechanical ventilation or a 
synonym. We screened 5,331 references, reviewed 539 full-text references, 
and excluded 120. Of the 419 studies (representing 38 countries) meeting 
inclusion criteria, 297 (71%) reported data on a heterogeneous subject 
cohort, and 66 (16%) included surgical subjects only (46 of those 66, 70% 
cardiac surgery). Other studies described COPD (16, 4%), trauma (22, 5%), 
neuromuscular (17, 4%), and sepsis (1, 0.2%) cohorts. A total of 741 terms 
were used to refer to the 419 study cohorts. The most common terms were: 
prolonged mechanical ventilation (253, 60%), admission to specialized unit 
(107, 26%), and long-term mechanical ventilation (79, 19%). Some authors 
(282, 67%) defined their cohorts based on duration of mechanical 
ventilation, with 154 studies (55%) using this as the sole criterion. We 
identified 37 different durations of ventilation ranging from 5 h to 1 y, 
with > 21 d being the most common (28 of 282, 7%). For studies describing a 
surgical cohort, minimum ventilation duration required for inclusion was ≥ 
24 h for 20 of 66 studies (30%). More than half of all studies (237, 57%) 
did not provide a reason/rationale for definitional criteria used, with only 
28 studies (7%) referring to a consensus definition. We conclude that 
substantial variation exists in the terminology and definitional criteria 
for cohorts of subjects receiving prolonged mechanical ventilation. 
Standardization of terminology and definitional criteria is required for 
study data to be maximally informative.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; 
EMTREE MEDICAL INDEX TERMS
  article; brain injury; chronic obstructive lung disease; clinical outcome; hemodynamics; hospital admission; hospital mortality; human; intubation; length of stay; neuromuscular disease; quality of life; sepsis; spinal cord injury; tracheostomy; ventilator weaning; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180680294
MEDLINE PMID
  28611229 (http://www.ncbi.nlm.nih.gov/pubmed/28611229)
PUI
  L623984871
DOI
  10.4187/respcare.05485
FULL TEXT LINK
  http://dx.doi.org/10.4187/respcare.05485
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19433654&id=doi:10.4187%2Frespcare.05485&atitle=Variation+in+definition+of+prolonged+mechanical+ventilation&stitle=Respir.+Care&title=Respiratory+Care&volume=62&issue=10&spage=1324&epage=1332&aulast=Rose&aufirst=Louise&auinit=L.&aufull=Rose+L.&coden=RECAC&isbn=&pages=1324-1332&date=2017&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 160
TITLE
  Airway Management Protocol after Anterior Cervical Spine Surgery
AUTHOR NAMES
  Kim M.; Choi I.; Park J.H.; Jeon S.R.; Rhim S.C.; Roh S.W.
AUTHOR ADDRESSES
  (Kim M.) Graduate School of Medicine, University of Ulsan, Seoul, South 
Korea.
(Choi I.) Department of Neurological Surgery, Dongtan Sacred Heart Hospital, 
College of Medicine, Hallym University, Hwaseong, Gyeonggi-Do, South Korea.
(Park J.H.) Department of Neurological Surgery, Gangneung Asan Medical 
Center, University of Ulsan College of Medicine, Seoul, South Korea.
(Jeon S.R., srjeon@amc.seoul.kr; Rhim S.C.; Roh S.W.) Department of 
Neurological Surgery, Asan Medical Center, University of Ulsan College of 
Medicine, 88, Olympic-RO 43-Gil, Songpa-Gu, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  S.R. Jeon, Department of Neurological Surgery, Asan Medical Center, 
University of Ulsan College of Medicine, 88, Olympic-RO 43-Gil, Songpa-Gu, 
Seoul, South Korea. Email: srjeon@amc.seoul.kr
AiP/IP ENTRY DATE
  2017-05-30
FULL RECORD ENTRY DATE
  2017-09-13
SOURCE
  Spine (2017) 42:18 (E1058-E1066). Date of Publication: 15 Sep 2017
VOLUME
  42
ISSUE
  18
FIRST PAGE
  E1058
LAST PAGE
  E1066
DATE OF PUBLICATION
  15 Sep 2017
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study Design. Retrospective comparative cohort analysis. Objective. To 
evaluate the effect of postoperative airway management protocol (ASAN 
Extubation Protocol, AEP) on incidence of airway complications for patients 
undergoing anterior cervical spine surgery (ACSS). Background. Postoperative 
airway compromise remains crucial for patients undergoing ACSS. Despite the 
potential severity of these complications, the data in the published 
literature addressing this issue is sparse. Methods. A retrospective cohort 
study was performed regarding airway complications (postoperative airway 
edema requiring unplanned reintubation or tracheostomy) between groups of 
patients undergoing ACSS before and after applying our standardized protocol 
(AEP) for postoperative extubation. The AEP was developed based on 5 
clinical risk factors reported having relation to airway complication. 
Postoperative patients with any oneor more risk factors were kept intubated 
for at least overnight and extubation was conducted according to the amount 
of prevertebral soft tissue swelling. Results. A total of 538 ACSS patients 
were identified from 2008 to 2016. The nonprotocol group (before protocol 
application, 275 patients) and the Protocol group (after protocol, 263 
patients) were compared; airway complication rates were significantly 
different between two groups (nonprotocol: 3.64% (10/275) vs. protocol: 
0.76% (2/263), P=0.024). The possible factors that may increase airway 
complication include operative indications (P=0.002), trauma (P=0.000), 
medical comorbidity risk (P=0.011), combined anterior and posterior surgery 
(P=0.002), and operation time longer than 5hours (P=0.045). In multivariate 
analysis, medical comorbidity risk, trauma, and airway protocol adoption 
were significant factors. AEP reduced the airway complication rate by odds 
ratio 0.125 (P=0.013). Conclusion. Postoperative airway complication is not 
very common after ACSS. AEP contributed to reduce the incidence of airway 
complications. The potentially life-threatening event of loss of airway 
patency, even though it is a rare complication, should be cautiously 
analyzed with identification of risk factors before the surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spine fusion; respiration control; 
EMTREE MEDICAL INDEX TERMS
  adult; age; article; body mass; clinical protocol; cohort analysis; comorbidity; controlled study; female; human; injury; major clinical study; male; medical history; middle aged; operation duration; postoperative care; postoperative complication (complication); postoperative edema (complication); priority journal; respiratory failure (complication); retrospective study; risk assessment; sex difference; smoking; standardization; surgical technique; therapy effect; tracheostomy; treatment indication; treatment outcome; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170373549
PUI
  L616399122
DOI
  10.1097/BRS.0000000000002236
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000002236
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000002236&atitle=Airway+Management+Protocol+after+Anterior+Cervical+Spine+Surgery&stitle=Spine&title=Spine&volume=42&issue=18&spage=E1058&epage=E1066&aulast=Kim&aufirst=Moinay&auinit=M.&aufull=Kim+M.&coden=SPIND&isbn=&pages=E1058-E1066&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 161
TITLE
  Classification and regression tree model for predicting tracheostomy in 
patients with traumatic cervical spinal cord injury
AUTHOR NAMES
  Lee D.-S.; Park C.-M.; Carriere K.C.; Ahn J.
AUTHOR ADDRESSES
  (Lee D.-S.) Department of Critical Care Medicine, Kangbuk Samsung Hospital, 
Sungkyunkwan University School of Medicine, Seoul, South Korea.
(Park C.-M., dr99.park@samsung.com) Department of Critical Care Medicine, 
Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 
Irwon-ro, Gangnam-gu, Seoul, South Korea.
(Park C.-M., dr99.park@samsung.com) Department of Surgery, Samsung Medical 
Center, Sungkyunkwan University, School of Medicine, Seoul, South Korea.
(Carriere K.C.; Ahn J.) Biostatistics and Clinical Epidemiology Center, 
Samsung Medical Centre, Seoul, South Korea.
(Carriere K.C.) Department of Mathematical and Statistical Sciences, 
University of Alberta, Edmonton, Canada.
CORRESPONDENCE ADDRESS
  C.-M. Park, Department of Critical Care Medicine, Samsung Medical Center, 
Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 
South Korea. Email: dr99.park@samsung.com
AiP/IP ENTRY DATE
  2017-05-04
FULL RECORD ENTRY DATE
  2018-10-22
SOURCE
  European Spine Journal (2017) 26:9 (2333-2339). Date of Publication: 1 Sep 
2017
VOLUME
  26
ISSUE
  9
FIRST PAGE
  2333
LAST PAGE
  2339
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  1432-0932 (electronic)
  0940-6719
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Purpose: In patients with cervical spinal cord injury (CSCI), respiratory 
compromise and the need for tracheostomy are common. The purpose of this 
study was to identify common risk factors for tracheostomy following 
traumatic CSCI and develop a decision tree for tracheostomy in traumatic 
CSCI patients without pulmonary function test. Methods: Data of 105 trauma 
patients with CSCI admitted in our institution from April, 2008 to February, 
2014 were retrospectively analyzed. Patients who underwent tracheostomy were 
compared to those who did not. Stepwise logistic regression analysis and 
classification and regression tree model were used to predict the risk 
factors for tracheostomy. Results: Tracheostomy was performed in 20% of 
patients with traumatic CSCI on median hospital day 4. Patients who 
underwent tracheostomy tended to be more severely injured (higher Injury 
Severity Score, lower Glasgow Coma Score, and lower systolic blood pressure 
on admission) which required more frequent intubation in the emergency room 
(ER) with a higher rate of complete CSCI compared to those who did not. Upon 
multiple logistic analysis, Age ≥ 55 years (OR: 6.86, p = 0.037), Car 
accident (OR: 5.8, p = 0.049), injury above C5 (OR: 28.95, p = 0.009), 
ISS ≥ 16 (OR: 12.6, p = 0.004), intubation in the ER (OR: 23.87, p = 0.001), 
and complete CSCI (OR: 62.14, p < 0.001) were significant predictors for the 
need of tracheostomy after CSCI. These factors can predict whether a new 
patient needs future tracheostomy with 91.4% accuracy. Conclusions: 
Age ≥ 55 years, injury above C5, ISS ≥ 16, Car accident, intubation in the 
ER, and complete CSCI were independently associated with tracheostomy after 
CSCI. CART analysis may provide an intuitive decision tree for tracheostomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; decision tree; disease classification; logistic regression analysis; tracheostomy; traumatic brain injury; 
EMTREE MEDICAL INDEX TERMS
  abdominal injury (complication); adult; article; comparative study; controlled study; emergency ward; female; Glasgow coma scale; hospital admission; hospital discharge; hospitalization; human; injury scale; injury severity; intubation; lung complication (complication); major clinical study; male; motor dysfunction (complication); pneumonia (complication); postoperative complication (complication); prediction; priority journal; retrospective study; surgical patient; surgical risk; systolic blood pressure; thorax injury (complication); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170308536
MEDLINE PMID
  28447274 (http://www.ncbi.nlm.nih.gov/pubmed/28447274)
PUI
  L615773215
DOI
  10.1007/s00586-017-5104-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-017-5104-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-017-5104-9&atitle=Classification+and+regression+tree+model+for+predicting+tracheostomy+in+patients+with+traumatic+cervical+spinal+cord+injury&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=26&issue=9&spage=2333&epage=2339&aulast=Lee&aufirst=Dae-Sang&auinit=D.-S.&aufull=Lee+D.-S.&coden=ESJOE&isbn=&pages=2333-2339&date=2017&auinit1=D&auinitm=-S
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 162
TITLE
  Dysphagia in acute cervical spinal cord injury-development of a screening 
tool through a Delphi process of expert consensus
AUTHOR NAMES
  McRae J.; Smith C.; Beeke S.; Emmanuel A.
AUTHOR ADDRESSES
  (McRae J.) Royal National Orthopaedic Hospital, Therapies Department, 
Stanmore, United Kingdom.
(McRae J.; Emmanuel A.) University College London, Division of Medicine, 
London, United Kingdom.
(Smith C.; Beeke S.) University College London,Psychology and Language 
Sciences, London, United Kingdom.
CORRESPONDENCE ADDRESS
  J. McRae, Royal National Orthopaedic Hospital, Therapies Department, 
Stanmore, United Kingdom.
FULL RECORD ENTRY DATE
  2017-11-07
SOURCE
  Intensive Care Medicine Experimental (2017) 5:2 Supplement 1. Date of 
Publication: 1 Sep 2017
VOLUME
  5
ISSUE
  2
DATE OF PUBLICATION
  1 Sep 2017
CONFERENCE NAME
  30th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2017
CONFERENCE LOCATION
  Vienna, Austria
CONFERENCE DATE
  2017-09-23 to 2017-09-27
ISSN
  2197-425X
BOOK PUBLISHER
  SpringerOpen
ABSTRACT
  INTRODUCTION. Dysphagia in cervical spinal cord injury (CSCI) is associated 
with respiratory complications, increased length of stay and mortality risks 
[1]. The cause is multi-factorial with subtle clinical presentation [2]. 
Early dysphagia identification helps to prevent complications (including 
silent aspiration) however a lack of national guidance and effective 
screening methods has led to varied clinical practices in non-specialised 
units resulting in poor outcomes [3]. OBJECTIVES. To use a Delphi technique, 
gathering expert consensus on risk factors for dysphagia, to develop a 
screening tool and clinical recommendations for critical care healthcare 
professionals. METHODS. Following a literature review, 85 statements were 
generated across seven domains: co-morbid factors, definition, screening, 
assessment, identification, management, to form the first round of a Delphi. 
A multi-disciplinary international expert panel of 27 clinicians ranked the 
statements using a 5 point Likert scale. Statements not achieving consensus 
of >70% of the panel were modified and recirculated for a subsequent round 
until levels of agreement were static. Participants received individual 
feedback at the end of each round detailing their response compared to the 
group's response. RESULTS. Following two rounds of the Delphi, 62 statements 
achieved consensus (round 1, 59%; round 2, 48%) with statements for 
dysphagia screening and assessment achieving the least consensus. Based on 
the results, a screening tool was developed to identify dysphagia risks with 
3 domains: injury risk (brain injury, cervical surgery, spinal injury level 
and severity); clinical risk (intubation, tracheostomy, ventilation, and 
nutrition) and urgency (chest infection, pyrexia, oral care and suction). A 
set of clinical recommendations provided additional guidance on optimal 
respiratory and nutritional management. CONCLUSIONS. This Delphi study 
achieved multi-professional consensus on factors contributing to dysphagia 
risk in CSCI allowing development of a screening tool. This will aid 
referral to Speech and Language Therapy for prompt and consistent diagnostic 
assessment and intervention in non-specialised units. A future multi-site 
pilot study of the tool is necessary to validate its utility and impact on 
patient outcomes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; Delphi study; dysphagia; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; aspiration; brain injury; chest infection; clinical practice; complication; controlled study; female; fever; human; intubation; Likert scale; mouth hygiene; multicenter study; nutrition; patient referral; pilot study; prevention; risk factor; speech and language rehabilitation; suction; surgery; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619044925
DOI
  10.1186/s40635-017-0151-4
FULL TEXT LINK
  http://dx.doi.org/10.1186/s40635-017-0151-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2197425X&id=doi:10.1186%2Fs40635-017-0151-4&atitle=Dysphagia+in+acute+cervical+spinal+cord+injury-development+of+a+screening+tool+through+a+Delphi+process+of+expert+consensus&stitle=Intensive+Care+Med.+Exp.&title=Intensive+Care+Medicine+Experimental&volume=5&issue=2&spage=&epage=&aulast=McRae&aufirst=J.&auinit=J.&aufull=McRae+J.&coden=&isbn=&pages=-&date=2017&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 163
TITLE
  Risk Analyses of Pressure Ulcer in Tetraplegic Spinal Cord-Injured Persons: 
A French Long-Term Survey
AUTHOR NAMES
  Le Fort M.; Espagnacq M.; Perrouin-Verbe B.; Ravaud J.-F.
AUTHOR ADDRESSES
  (Le Fort M., marc.lefort@chu-nantes.fr; Perrouin-Verbe B.) Neurological 
Physical Medicine and Rehabilitation Department, University Hospital–Hôpital 
Saint-Jacques, Nantes, France.
(Le Fort M., marc.lefort@chu-nantes.fr; Ravaud J.-F.) MSSH, House of Social 
Sciences and Disability–EHESP, High School of Public Health, Rennes, France.
(Espagnacq M.) IRDES–Institute for Research and Documentation in Health 
Economics, Paris, France.
(Ravaud J.-F.) CERMES3, INSERM, CNRS, EHESS, Université Paris Descartes, 
Villejuif, France.
CORRESPONDENCE ADDRESS
  M. Le Fort, Service de Médecine Physique et de Réadaptation neurologique - 
Hôpital Saint-Jacques - 85, rue Saint-Jacques, cedex 01, Nantes, France. 
Email: marc.lefort@chu-nantes.fr
AiP/IP ENTRY DATE
  2017-03-29
FULL RECORD ENTRY DATE
  2017-09-15
SOURCE
  Archives of Physical Medicine and Rehabilitation (2017) 98:9 (1782-1791). 
Date of Publication: 1 Sep 2017
VOLUME
  98
ISSUE
  9
FIRST PAGE
  1782
LAST PAGE
  1791
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  1532-821X (electronic)
  0003-9993
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Objective To identify the long-term clinical, individual, and social risk 
factors for the development of pressure ulcers (PUs) in traumatic spinal 
cord–injured persons with tetraplegia (TSCIt). Design Cohort survey with 
self-applied questionnaires in 1995 and 2006. Setting Thirty-five 
French-speaking European physical medicine and rehabilitation centers 
participating in the Tetrafigap surveys. Participants Tetraplegic adults 
(N=1641) were surveyed after an initial posttraumatic period of at least 2 
years. Eleven years later, a follow-up was done for 1327 TSCIt, among whom 
221 had died and 547 could be surveyed again. Interventions Not applicable. 
Main Outcome Measures The proportion of PUs documented at the various 
defined time points, relative to the medical and social situations of the 
TSCIt, by using univariate analyses followed by logistic regression. Results 
Of the participants, 73.4% presented with a PU during at least 1 period 
after their injury. Four factors had an effect on the occurrence of PUs in 
the long-term. Protective features for this population were incomplete motor 
impairment (odds ratio, 0.5) and the ability to walk (odds ratio, 0.2), 
whereas a strong predictive factor was the development of a PU during the 
initial posttrauma phase (odds ratio, 2.7). Finally, a significant 
situational factor was the lack of a social network (odds ratio, 3.1). 
Conclusions We believe that the highlighting of a motor incomplete feature 
of SCI (protective against the development of a PU) and of a medical risk 
factor, an early PU (which served as a definitive marker of the trajectory 
of TSCIt), together with a social situational factor, indicates the crucial 
role of initial management and long-term follow-up.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  decubitus (complication); quadriplegia (rehabilitation); spinal cord injury (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; article; brain injury; cohort analysis; employment status; female; follow up; French (language); home accident; human; longitudinal study; major clinical study; male; marriage; motor dysfunction; risk assessment; risk factor; sensory dysfunction; social network; social participation; sport injury; tracheotomy; traffic accident; treatment duration; 
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Rehabilitation and Physical Medicine (19)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170223962
MEDLINE PMID
  28130079 (http://www.ncbi.nlm.nih.gov/pubmed/28130079)
PUI
  L615002848
DOI
  10.1016/j.apmr.2016.12.017
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2016.12.017
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1532821X&id=doi:10.1016%2Fj.apmr.2016.12.017&atitle=Risk+Analyses+of+Pressure+Ulcer+in+Tetraplegic+Spinal+Cord-Injured+Persons%3A+A+French+Long-Term+Survey&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=98&issue=9&spage=1782&epage=1791&aulast=Le+Fort&aufirst=Marc&auinit=M.&aufull=Le+Fort+M.&coden=APMHA&isbn=&pages=1782-1791&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 164
TITLE
  Bilateral vocal cord paralysis caused by hanging
AUTHOR NAMES
  Lerrick A.J.
AUTHOR ADDRESSES
  (Lerrick A.J.)
CORRESPONDENCE ADDRESS
  A.J. Lerrick,
FULL RECORD ENTRY DATE
  2017-09-13
SOURCE
  Otolaryngology - Head and Neck Surgery (United States) (2017) 157:1 
Supplement 1 (P224). Date of Publication: 1 Sep 2017
VOLUME
  157
ISSUE
  1
FIRST PAGE
  P224
DATE OF PUBLICATION
  1 Sep 2017
CONFERENCE NAME
  Annual Meeting of the American Academy of Otolaryngology-Head and Neck 
Surgery Foundation and OTO Experience, AAO-HNSF 2017
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2017-09-10 to 2017-09-13
ISSN
  1097-6817
BOOK PUBLISHER
  SAGE Publications Inc.
ABSTRACT
  Objectives: Death by hanging is typically accomplished by severing the 
spinal cord or by strangulation. A patient's failed suicide attempt by 
hanging enabled hospital care to be rendered. Bilateral vocal cord paralysis 
was identified, possibly the first reported case of this entity. Methods: A 
56-year-old man was found unconscious following an attempted suicide by 
hanging. Cardiopulmonary resuscitation restored spontaneous circulation. The 
preliminary diagnosis was asphyxiation. A 9-cm-long 4-mm-wide excoriation 
extended from the left anterior neck to the right posterior triangle, 
overlying the inferior thyroid cartilage. It was postulated that his neck 
had been flexed rightward and hyperextended on the left. Imaging revealed 
normal cervical spine alignment and cervical soft-tissue edema, R > L. An 
angiogram was unremarkable. Early extubation failed because of stridor and 
dyspnea but was successful at 1 week. The patient had inspiratory > 
expiratory stridor. His voice was hypophonic and raspy. Laryngoscopy 
identified right vocal cord paralysis (0/4) and left vocal cord paresis 
(<1/4). Both cords were medialized. A tracheotomy secured the patient's 
airway. Three months postinjury, vocal cord function was fully recovered, 
permitting decannulation. Results: Clinical findings suggested compression 
of the right and stretching of the left vagus nerves. It is entirely 
possible that the right recurrent laryngeal nerve was compressed as it 
entered the larynx at the cricothyroid articulation and that the left 
recurrent laryngeal nerve was stretched at the same anatomic level. 
Conclusions: The vagus nerves may have been more resilient when injured than 
the more deeply situated recurrent laryngeal nerves regardless of the 
mechanism.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  vocal cord paralysis; 
EMTREE MEDICAL INDEX TERMS
  adult; case report; cervical spine; diagnosis; dyspnea; edema; ego development; extubation; female; human; human tissue; laryngoscopy; male; middle aged; recurrent laryngeal nerve; remission; resuscitation; soft tissue; stridor; suffocation; suicide attempt; thyroid cartilage; tracheostomy; vagus nerve; voice; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L618213130
DOI
  10.1177/0194599817717250
FULL TEXT LINK
  http://dx.doi.org/10.1177/0194599817717250
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10976817&id=doi:10.1177%2F0194599817717250&atitle=Bilateral+vocal+cord+paralysis+caused+by+hanging&stitle=Otolaryngol.+Head+Neck+Surg.&title=Otolaryngology+-+Head+and+Neck+Surgery+%28United+States%29&volume=157&issue=1&spage=P224&epage=&aulast=Lerrick&aufirst=Andrew+J.&auinit=A.J.&aufull=Lerrick+A.J.&coden=&isbn=&pages=P224-&date=2017&auinit1=A&auinitm=J
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 165
TITLE
  Reconstructive surgery of brachiocephalic artery to severe multiple 
handicapped children with central airway stenosis
AUTHOR NAMES
  Mitsuoka M.; Takamori S.; Kashihara M.; Yoshiyama K.; Akagi Y.
AUTHOR ADDRESSES
  (Mitsuoka M.; Takamori S.; Kashihara M.; Yoshiyama K.; Akagi Y.) Kurume 
Univ., Fukuoka, Japan.
CORRESPONDENCE ADDRESS
  M. Mitsuoka, Kurume Univ., Fukuoka, Japan.
FULL RECORD ENTRY DATE
  2019-01-11
SOURCE
  European Respiratory Journal (2017) 50 Supplement 61. Date of Publication: 1 
Sep 2017
VOLUME
  50
DATE OF PUBLICATION
  1 Sep 2017
CONFERENCE NAME
  European Respiratory Society International Congress, ERS 2017
CONFERENCE LOCATION
  Milan, Italy
CONFERENCE DATE
  2017-09-09 to 2017-09-13
ISSN
  1399-3003
BOOK PUBLISHER
  European Respiratory Society
ABSTRACT
  Background: Tracheal stenosis due to narrowing between the sternum and the 
vertebrae is sometimes recognized in severe multiple handicapped children. 
We report two cases of successful surgery with aorto-brachiocephalic artery 
bypass graft. SUBJECTS: Case 1 was 19 years boy who had spinal injury by 
traffic accident when he was seventeen. He was performed tracheostomy and 
prolonged mechanical ventilation. After weaning from mechanical ventilation, 
he became bedridden due to tetraplegia. One year later, he was admitted to a 
hospital emergency caused by sever tracheal stenosis and inserted a silicone 
stent to his trachea. Five months later, he was hospitalized again due to 
tracheal stenosis. He transferred to our hospital and performed 
aorto-brachiocephalic bypass graft. He miraculously escaped death. Case 2 
was 11 years boy with severe multiple handicapped due to head injury when he 
was one year old. When he transferred to our hospital, his trachea was 
severe flat stenosis due to compression by a brachiocephalic artery. We 
performed aorto-brachiocephalic bypass graft to him. Results: Case 1 could 
spent his life at his home after surgery, unfortunately he was died by 
pneumoniae 12 months after the surgery. Case 2 is still fine more than 2 
years after the operation. Conclusions: The management of children with 
tracheostomy and severe mental and physical handicaps is usually difficult. 
The surgery described in this report could improve airway stenosis and avoid 
dangerous tracheo-arterial fistula. Since there are no report of prolonged 
outcome after this surgery, we need to discuss and continue following up 
this procedure.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway; brachiocephalic trunk; handicapped child; reconstructive surgery; trachea stenosis; 
EMTREE MEDICAL INDEX TERMS
  artery bypass; case report; child; clinical article; compression; conference abstract; death; fistula; head injury; human; immobility; infant; male; mental deficiency; quadriplegia; spine injury; stent; surgery; tracheostomy; traffic accident; ventilator weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L625789097
DOI
  10.1183/1393003.congress-2017.PA2453
FULL TEXT LINK
  http://dx.doi.org/10.1183/1393003.congress-2017.PA2453
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13993003&id=doi:10.1183%2F1393003.congress-2017.PA2453&atitle=Reconstructive+surgery+of+brachiocephalic+artery+to+severe+multiple+handicapped+children+with+central+airway+stenosis&stitle=Eur.+Respir.+J.&title=European+Respiratory+Journal&volume=50&issue=&spage=&epage=&aulast=Mitsuoka&aufirst=Masahiro&auinit=M.&aufull=Mitsuoka+M.&coden=&isbn=&pages=-&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 166
TITLE
  PM and R consults for combined TBI/sci patients in the shock trauma ICU 
impact ventilation days, morbidity, and disposition: A retrospective study
AUTHOR NAMES
  Linville C.R.; Morris M.; Chacko J.J.; Verduzco-Gutierrez M.; Stampas A.
AUTHOR ADDRESSES
  (Linville C.R.) Univ of TX-UT Houston, Houston, United States.
(Morris M.; Chacko J.J.; Verduzco-Gutierrez M.; Stampas A.)
CORRESPONDENCE ADDRESS
  C.R. Linville, Univ of TX-UT Houston, Houston, United States.
FULL RECORD ENTRY DATE
  2018-03-02
SOURCE
  PM and R (2017) 9:9 Supplement 1 (S163). Date of Publication: 1 Sep 2017
VOLUME
  9
ISSUE
  9
FIRST PAGE
  S163
DATE OF PUBLICATION
  1 Sep 2017
CONFERENCE NAME
  2017 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation, AAPM and R 2017
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2017-10-12 to 2017-10-15
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Objective: Determine differences in characteristics, complications, length 
of stay and disposition for combined traumatic brain injury and spinal cord 
injury (SCI) patients admitted to the shock trauma intensive care unit 
(STICU) who received and did not receive a physical medicine and 
rehabilitation (PMR) consult. Design: A retrospective clinical study was 
conducted of acute trauma patients admitted to the STICU at a Level 1 trauma 
center with acute care stay days of at least 14 days. Patients admitted from 
January 1, 2013, through December 31, 2013, who were 16 years of age or 
older with a spinal cord injury diagnosis were included in this study. 
General characteristics, complications and disposition were then recorded 
and analyzed for these patients. Setting: Level I Trauma Center. 
Participants: 36 patients met inclusion criteria. Interventions: Not 
applicable. Main Outcome Measures: Demographics, characteristics, 
complications, length of stay, disposition. Results: 36 patients had a 
combined TBI/SCI. There were no significant differences in patient 
characteristics if PMR was or was not consulted. Complications for combined 
TBI/SCI patients with a PMR consult, compared to those without a PMR consult 
e dysphagia requiring PEG/PEJ placement: 15 vs. 0 (p=.01). There were no 
other significant differences in other complications including pneumonia, 
UTI, PE, DVT, or tracheostomy placement. There were no significant 
differences in length of stay, however, patients with a PMR consult had more 
ventilation free days compared to those without a PMR consult: 13.5 vs. 8.5 
(p=.04). Disposition for combined TBI/SCI patients with a PMR consult, 
compared to those without a PMR consult-Inpatient rehabilitation: 14 vs. 0 
(p=.01); LTAC: 5 vs. 4 (p=.08); SNF: 3 vs. 0 (p=1); home: 3 vs. 2 (p=.1). 
Conclusions: This retrospective study shows combined TBI/SCI patients with a 
PMR consult were more likely to require gastrostomy tube placement, had more 
ventilation free days, and were more likely to discharge to inpatient 
rehabilitation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; morbidity; retrospective study; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; clinical article; complication; conference abstract; controlled study; diagnosis; dysphagia; emergency care; emergency health service; female; hospital patient; human; intensive care unit; length of stay; male; outcome assessment; pneumonia; rehabilitation; rehabilitation medicine; stomach tube; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L620887071
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=PM+and+R+consults+for+combined+TBI%2Fsci+patients+in+the+shock+trauma+ICU+impact+ventilation+days%2C+morbidity%2C+and+disposition%3A+A+retrospective+study&stitle=PM+R&title=PM+and+R&volume=9&issue=9&spage=S163&epage=&aulast=Linville&aufirst=Cole+R.&auinit=C.R.&aufull=Linville+C.R.&coden=&isbn=&pages=S163-&date=2017&auinit1=C&auinitm=R
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 167
TITLE
  Percutaneous tracheostomy: A comprehensive review
AUTHOR NAMES
  Rashid A.O.; Islam S.
AUTHOR ADDRESSES
  (Rashid A.O.; Islam S., shaheen.islam@osumc.edu) Interventional Pulmonology, 
Division of Pulmonary Allergy, Critical Care and Sleep Medicine, The Ohio 
State University Wexner Medical Center, Columbus, United States.
CORRESPONDENCE ADDRESS
  S. Islam, Interventional Pulmonology, Division of Pulmonary, Allergy, 
Critical Care and Sleep Medicine, The Ohio State University Wexner Medical 
Center, Suite 201 DHLRI, 473 W 12th Avenue, Columbus, United States. Email: 
shaheen.islam@osumc.edu
AiP/IP ENTRY DATE
  2017-09-18
FULL RECORD ENTRY DATE
  2017-09-19
SOURCE
  Journal of Thoracic Disease (2017) 9 Supplement10 (S1128-S1138). Date of 
Publication: 1 Sep 2017
VOLUME
  9
FIRST PAGE
  S1128
LAST PAGE
  S1138
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  2077-6624 (electronic)
  2072-1439
BOOK PUBLISHER
  AME Publishing Company, jtd@thepbpc.org
ABSTRACT
  Tracheostomy is a common procedure. It can be done surgically or 
percutaneously by dilating the stoma using Seldinger technique. Percutaneous 
tracheostomy (PT) is now routinely performed by surgeons and non-surgeons 
such as intensivists and anesthesiologists in the intensive care units (ICU) 
all over the world. Although obesity, emergent tracheostomy, coagulopathy, 
inability to extend the neck and high ventilator demand (HVD) were initially 
thought to be a relative contraindication, recent data suggest safety of PT 
in these patient population. Ultrasound can be helpful in limited cases to 
identify the neck structure especially in patients with a difficult anatomy. 
Bronchoscopy during PT can shorten the duration and avoid complications. PT 
has favorable complication rate, lower infection rate, shorter procedural 
duration and is cost-effective. Experience with the technique and careful 
planning is needed to minimize any avoidable potential complication.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  percutaneous tracheostomy; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult respiratory distress syndrome (therapy); artificial ventilation; blood clotting disorder; bronchoscopy; cannulation; complication; endotracheal tube; human; hypotension; intermethod comparison; medical education; nonsurgical invasive therapy; obesity; open surgery; Portex ULTRAperc; positive end expiratory pressure; review; safety; spinal cord injury; suture; tracheal dilator; tracheostomy kit; tracheostomy tube; treatment contraindication; treatment indication; ultrasound; 
DEVICE TRADE NAMES
  Ciaglia Blue Rhino  , United StatesCook Medical

  Portex ULTRAperc  , United StatesSmiths Medical

DEVICE MANUFACTURERS
   (United States)Cook Medical
   (United States)Smiths Medical
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170646404
PUI
  L618261034
DOI
  10.21037/jtd.2017.09.33
FULL TEXT LINK
  http://dx.doi.org/10.21037/jtd.2017.09.33
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20776624&id=doi:10.21037%2Fjtd.2017.09.33&atitle=Percutaneous+tracheostomy%3A+A+comprehensive+review&stitle=J.+Thorac.+Dis.&title=Journal+of+Thoracic+Disease&volume=9&issue=&spage=S1128&epage=S1138&aulast=Rashid&aufirst=Ashraf+O.&auinit=A.O.&aufull=Rashid+A.O.&coden=&isbn=&pages=S1128-S1138&date=2017&auinit1=A&auinitm=O
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 168
TITLE
  Tandem spinal stenosis a systematic review
AUTHOR NAMES
  Overley S.C.; Kim J.S.; Gogel B.A.; Merrill R.K.; Hecht A.C.
AUTHOR ADDRESSES
  (Overley S.C.; Kim J.S.; Gogel B.A.; Merrill R.K.; Hecht A.C., 
Andrew.hecht@mountsinai.org) Department of Spine Surgery, Icahn School of 
Medicine at Mount Sinai, New York, United States.
AiP/IP ENTRY DATE
  2017-11-08
FULL RECORD ENTRY DATE
  2018-06-05
SOURCE
  JBJS Reviews (2017) 5:9 Article Number: e2. Date of Publication: 1 Sep 2017
VOLUME
  5
ISSUE
  9
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  2329-9185 (electronic)
BOOK PUBLISHER
  Journal of Bone and Joint Surgery Inc.
ABSTRACT
  Background: Tandem spinal stenosis refers to spinal canal diameter narrowing 
in at least 2 distinct regions of the spine, most commonly the lumbar and 
cervical regions. This entity can be an asymptomatic radiographic finding, 
or it can present with severe myelopathy and lower-extremity symptoms. 
Tandem spinal stenosis may impact surgeon decision-making when planning 
either cervical or lumbar spine surgery, and there is currently no consensus 
in the literature regarding the treatment algorithm for operative 
intervention. Methods: A MEDLINE literature search was performed using 
PubMed, the Cochrane Database of Systematic Reviews, and Embase from January 
1980 to February 2015 using Medical Subject Heading queries for the terms 
“tandem spinal stenosis,” “cervical stenosis AND lumbar stenosis,” and 
“concomitant spinal stenosis.” We included studies involving adult patients, 
tandem spinal stenosis of the cervical and lumbar regions, and a minimum of 
5 patients. Articles that did not discuss spinal disorders or only explored 
disorders at a single spinal region were excluded. Results: The initial 
database review resulted in 234 articles. After abstracts were reviewed, 
only 17 articles that met inclusion criteria were identified: 2 cadaveric 
studies, 5 clinical studies of patients with radiographic tandem spinal 
stenosis, and 10 clinical studies of patients with symptomatic tandem spinal 
stenosis. Conclusions: Tandem spinal stenosis is a common condition present 
in up to 60% of patients with spinal stenosis. This disorder, however, is 
often overlooked, which can lead to serious complications. Identification of 
tandem spinal stenosis is paramount as a first step in management and, 
although there is still no preferred intervention, both staged and 
simultaneous procedures have been shown to be effective. Surgeons may 
utilize a single, staged, or combined approach to decompression, always 
addressing cervical myelopathy as a priority.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  vertebral canal stenosis; 
EMTREE MEDICAL INDEX TERMS
  bibliographic database; bone radiography; cauda equina; cervical myelopathy; clinical outcome; decompression; hematoma; human; morphology; ossification; patient positioning; quality control; reoperation; review; septicemia; spondylolisthesis; spondylosis; systematic review; tracheostomy; wound infection; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170769032
MEDLINE PMID
  28872572 (http://www.ncbi.nlm.nih.gov/pubmed/28872572)
PUI
  L619067187
DOI
  10.2106/JBJS.RVW.17.00007
FULL TEXT LINK
  http://dx.doi.org/10.2106/JBJS.RVW.17.00007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23299185&id=doi:10.2106%2FJBJS.RVW.17.00007&atitle=Tandem+spinal+stenosis+a+systematic+review&stitle=JBJS+Rev.&title=JBJS+Reviews&volume=5&issue=9&spage=&epage=&aulast=Overley&aufirst=Samuel+C.&auinit=S.C.&aufull=Overley+S.C.&coden=&isbn=&pages=-&date=2017&auinit1=S&auinitm=C
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 169
TITLE
  Reconstruction of late esophagus perforation after anterior cervical spine 
fusion with an adipofascial anterolateral thigh free flap: A case report
AUTHOR NAMES
  Coelho R.; Ekberg T.; Svensson M.; Mani M.; Rodriguez-Lorenzo A.
AUTHOR ADDRESSES
  (Coelho R.; Mani M.; Rodriguez-Lorenzo A., 
andres.rodriguez.lorenzo@surgsci.uu.se) Department of Plastic and 
Maxillofacial Surgery, Uppsala University Hospital and Department of 
Surgical Sciences, Uppsala University, Uppsala, Sweden.
(Ekberg T.; Svensson M.) Department of Otorhinolaryngology, Head and Neck 
Surgery, Uppsala University Hospital, Uppsala, Sweden.
CORRESPONDENCE ADDRESS
  A. Rodriguez-Lorenzo, Department of Plastic and Maxillofacial Surgery, 
Uppsala University Hospital and Department of Surgical Sciences, Uppsala 
University, Uppsala, Sweden. Email: andres.rodriguez.lorenzo@surgsci.uu.se
AiP/IP ENTRY DATE
  2017-04-25
FULL RECORD ENTRY DATE
  2018-07-20
SOURCE
  Microsurgery (2017) 37:6 (684-688). Date of Publication: 1 Sep 2017
VOLUME
  37
ISSUE
  6
FIRST PAGE
  684
LAST PAGE
  688
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  1098-2752 (electronic)
  0738-1085
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Reconstruction of late esophageal perforation usually requires flap surgery 
to achieve wound healing. However, restoring the continuity between the 
digestive tract and retropharyngeal space to allow for normal swallowing 
remains a technical challenge. In this report, we describe the use of a thin 
and pliable free adipofascial anterolateral thigh (ALT) flap in a 
47-year-old tetraplegic man with a history of C5–C6 fracture presented with 
a large posterior esophagus wall perforation allowing an easier flap 
insetting for a successful wound closure. The postoperative course was 
uneventful and mucosalization of the flap was confirmed by esophagoscopy 4 
weeks postsurgery. The patient tolerated normal diet and maintained normal 
swallowing during a follow-up of 3 years postoperatively. The adipofascial 
ALT flap may provide easier insetting due to the thin and pliable layer of 
adipofascial tissue for reconstructing large defects of the posterior wall 
of the esophagus by filling the retroesophageal space.
EMTREE DRUG INDEX TERMS
  barium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adipofascial flap; anterior spine fusion; anterolateral thigh flap; cervical spine; esophagus perforation (surgery); esophagus reconstruction; free tissue graft; reconstructive surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; anastomosis; article; case report; clinical article; computer; debridement; esophagoscopy; feeding apparatus; human; male; medical history; middle aged; nutrition; percutaneous endoscopic gastrostomy; priority journal; quadriplegia; spine fracture; swallowing; tracheostomy; wound healing; 
CAS REGISTRY NUMBERS
  barium (7440-39-3)
EMBASE CLASSIFICATIONS
  Gastroenterology (48)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170286811
MEDLINE PMID
  28397296 (http://www.ncbi.nlm.nih.gov/pubmed/28397296)
PUI
  L615542512
DOI
  10.1002/micr.30170
FULL TEXT LINK
  http://dx.doi.org/10.1002/micr.30170
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10982752&id=doi:10.1002%2Fmicr.30170&atitle=Reconstruction+of+late+esophagus+perforation+after+anterior+cervical+spine+fusion+with+an+adipofascial+anterolateral+thigh+free+flap%3A+A+case+report&stitle=Microsurgery&title=Microsurgery&volume=37&issue=6&spage=684&epage=688&aulast=Coelho&aufirst=Ruben&auinit=R.&aufull=Coelho+R.&coden=MSRGD&isbn=&pages=684-688&date=2017&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 170
TITLE
  Reoperative repair of descending thoracic and thoracoabdominal aneurysms
AUTHOR NAMES
  Lau C.; Gaudino M.; Gambardella I.; Mills E.; Munjal M.; Elsayed M.; Girardi L.
AUTHOR ADDRESSES
  (Lau C.; Gaudino M.; Gambardella I.; Mills E.; Munjal M.; Elsayed M.; 
Girardi L.) Department of Cardiothoracic Surgery, Weill Cornell Medical 
College, New York, NY, USA
FULL RECORD ENTRY DATE
  2018-05-23
SOURCE
  European journal of cardio-thoracic surgery : official journal of the 
European Association for Cardio-thoracic Surgery (2017) 52:3 (501-507). Date 
of Publication: 1 Sep 2017
VOLUME
  52
ISSUE
  3
FIRST PAGE
  501
LAST PAGE
  507
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  1873-734X (electronic)
ABSTRACT
  OBJECTIVES: To evaluate the results of reoperation on descending thoracic 
and thoracoabdominal aneurysms.METHODS: Sixty-nine consecutive patients 
undergoing reoperative aneurysm repair (20 descending thoracic and 49 
thoracoabdominal) were compared to 602 contemporary primary repairs. 
Propensity matching was used to reduce observable differences in 
preoperative characteristics.RESULTS: The reoperation group was younger 
(60.2 vs 65.3 years, P = 0.005) and less were extent I or II (28.6% vs 76%, 
P < 0.001). In the reoperation group, 82.6% were repaired with 
clamp-and-sew, 14.5% circulatory arrest and 2.9% partial bypass versus the 
primary surgery group 62.1%, 8.1% and 29.7%, respectively (P < 0.001). In 
the reoperation versus primary surgery group, respectively, spinal drainage 
was used in 73.9% vs 83.7% (P = 0.05), intercostal reimplantation in 11.6% 
vs 44.2% (P < 0.001), and cold renal perfusion in 36.2% vs 19.8% (P = 
0.001). Operative mortality was comparable (8.7% vs 5.3% primary, P = 0.25) 
but the reoperative extent I subgroup had higher mortality (20% vs 3.1%; P = 
0.04). Incidence of major complications was comparable (stroke 0 vs 0.9%, 
tracheostomy 5.8% vs 8%, renal failure 7.2% vs 5%, spinal cord injury 4.3% 
vs 2.7%; P > 0.05 for all variables), with the exception of myocardial 
infarction (2.9% vs 0.5%, P = 0.028). Five-year survival was 57.6% in 
reoperations and 58% in the primary surgery group (P = 0.878). No 
differences in the in-hospital and follow-up outcomes were found in the 
propensity matched comparison.CONCLUSIONS: Reoperative repair of descending 
thoracic and thoracoabdominal aneurysms can be safely performed with 
reasonable in-hospital and follow-up outcomes compared to primary aneurysm 
repair.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  procedures; 
EMTREE MEDICAL INDEX TERMS
  abdominal aortic aneurysm (surgery); aged; cause of death; dissecting aneurysm (surgery); female; follow up; hospital mortality; human; incidence; male; middle aged; mortality; New York; postoperative complication (epidemiology); reoperation; retrospective study; survival rate; thoracic aorta aneurysm (surgery); trends; vascular surgery; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  28460036 (http://www.ncbi.nlm.nih.gov/pubmed/28460036)
PUI
  L622205059
DOI
  10.1093/ejcts/ezx072
FULL TEXT LINK
  http://dx.doi.org/10.1093/ejcts/ezx072
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1873734X&id=doi:10.1093%2Fejcts%2Fezx072&atitle=Reoperative+repair+of+descending+thoracic+and+thoracoabdominal+aneurysms&stitle=Eur+J+Cardiothorac+Surg&title=European+journal+of+cardio-thoracic+surgery+%3A+official+journal+of+the+European+Association+for+Cardio-thoracic+Surgery&volume=52&issue=3&spage=501&epage=507&aulast=Lau&aufirst=Christopher&auinit=C.&aufull=Lau+C.&coden=&isbn=&pages=501-507&date=2017&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2018 Medline is the source for the citation and abstract of this 
record.

RECORD 171
TITLE
  Lysosomal Storage Diseases: Past, Present, and Future
AUTHOR NAMES
  Richtsfeld M.; Belani K.G.
AUTHOR ADDRESSES
  (Richtsfeld M.) Department of Anesthesiology, University of Minnesota 
Medical School, Minneapolis, United States.
(Richtsfeld M.) Pediatric Cardiac Anesthesia, University of Minnesota 
Masonic Children's Hospital, Minneapolis, United States.
(Belani K.G., belan001@umn.edu) Department of Anesthesiology, Pediatrics and 
Medicine, University of Minnesota Medical School, University of Minnesota 
Masonic Children's Hospital, Minneapolis, United States.
(Belani K.G., belan001@umn.edu) Department of Pediatric Anesthesiology, 
University of Minnesota Masonic Children's Hospital, Minneapolis, United 
States.
CORRESPONDENCE ADDRESS
  K.G. Belani, Department of Anesthesiology, Pediatrics and Medicine, 
University of Minnesota Medical School, University of Minnesota Masonic 
Children's Hospital, Minneapolis, United States. Email: belan001@umn.edu
AiP/IP ENTRY DATE
  2017-11-06
FULL RECORD ENTRY DATE
  2017-11-09
SOURCE
  Anesthesia and Analgesia (2017) 125:3 (716-718). Date of Publication: 1 Sep 
2017
VOLUME
  125
ISSUE
  3
FIRST PAGE
  716
LAST PAGE
  718
DATE OF PUBLICATION
  1 Sep 2017
ISSN
  1526-7598 (electronic)
  0003-2999
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
EMTREE DRUG INDEX TERMS
  lysosome enzyme (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lysosome storage disease (drug therapy, drug therapy, therapy); 
EMTREE MEDICAL INDEX TERMS
  bone marrow transplantation; comorbidity; elective surgery; endotracheal intubation; enzyme replacement; human; laryngeal mask; priority journal; review; spinal cord compression; tracheostomy; videolaryngoscope; 
EMBASE CLASSIFICATIONS
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170763715
MEDLINE PMID
  28817523 (http://www.ncbi.nlm.nih.gov/pubmed/28817523)
PUI
  L619030355
DOI
  10.1213/ANE.0000000000001887
FULL TEXT LINK
  http://dx.doi.org/10.1213/ANE.0000000000001887
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15267598&id=doi:10.1213%2FANE.0000000000001887&atitle=Lysosomal+Storage+Diseases%3A+Past%2C+Present%2C+and+Future&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=125&issue=3&spage=716&epage=718&aulast=Richtsfeld&aufirst=Martina&auinit=M.&aufull=Richtsfeld+M.&coden=AACRA&isbn=&pages=716-718&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 172
TITLE
  Successful Reinnervation of the Diaphragm After Intercostal to Phrenic Nerve 
Neurotization in Patients With High Spinal Cord Injury
AUTHOR NAMES
  Nandra K.S.; Harari M.; Price T.P.; Greaney P.J.; Weinstein M.S.
AUTHOR ADDRESSES
  (Nandra K.S.) From the Department of Surgery, Thomas Jefferson University 
Hospital, Philadelphia, PA
(Harari M.; Price T.P.; Greaney P.J.; Weinstein M.S.)
FULL RECORD ENTRY DATE
  2018-05-23
SOURCE
  Annals of plastic surgery (2017) 79:2 (180-182). Date of Publication: 1 Aug 
2017
VOLUME
  79
ISSUE
  2
FIRST PAGE
  180
LAST PAGE
  182
DATE OF PUBLICATION
  1 Aug 2017
ISSN
  1536-3708 (electronic)
ABSTRACT
  OBJECTIVE: Our objective in this study was to extend diaphragmatic pacing 
therapy to include paraplegic patients with high cervical spinal cord 
injuries between C3 and C5.INTRODUCTION: Diaphragmatic pacing has been used 
in patients experiencing ventilator-dependent respiratory failure due to 
spinal cord injury as a means to reduce or eliminate the need for mechanical 
ventilation. However, this technique relies on intact phrenic nerve 
function. Recently, phrenic nerve reconstruction with intercostal nerve 
grafting has expanded the indications for diaphragmatic pacing. Our study 
aimed to evaluate early outcomes and efficacy of intercostal nerve transfer 
in diaphragmatic pacing.METHODS: Four ventilator-dependent patients with 
high cervical spinal cord injuries were selected for this study. Each 
patient demonstrated absence of phrenic nerve function via external neck 
stimulation and laparoscopic diaphragm mapping. Each patient underwent 
intercostal to phrenic nerve grafting with implantation of a phrenic nerve 
pacer. The patients were followed, and ventilator dependence was reassessed 
at 1 year postoperatively.RESULTS: Our primary outcome was measured by the 
amount of time our patients tolerated off the ventilator per day. We found 
that all 4 patients have tolerated paced breathing independent of mechanical 
ventilation, with 1 patient achieving 24 hours of tracheostomy 
collar.CONCLUSIONS: From this study, intercostal to phrenic nerve transfer 
seems to be a promising approach in reducing or eliminating ventilator 
support in patients with C3 to C5 high spinal cord injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  innervation; procedures; transplantation; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; cervical vertebra; complication; diaphragm; follow up; human; intercostal nerve; male; nerve transplantation; paraplegia; phrenic nerve; respiratory failure (etiology, surgery, therapy); spinal cord injury; treatment outcome; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  28570440 (http://www.ncbi.nlm.nih.gov/pubmed/28570440)
PUI
  L622205304
DOI
  10.1097/SAP.0000000000001105
FULL TEXT LINK
  http://dx.doi.org/10.1097/SAP.0000000000001105
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15363708&id=doi:10.1097%2FSAP.0000000000001105&atitle=Successful+Reinnervation+of+the+Diaphragm+After+Intercostal+to+Phrenic+Nerve+Neurotization+in+Patients+With+High+Spinal+Cord+Injury&stitle=Ann+Plast+Surg&title=Annals+of+plastic+surgery&volume=79&issue=2&spage=180&epage=182&aulast=Nandra&aufirst=Kulvir+S.&auinit=K.S.&aufull=Nandra+K.S.&coden=&isbn=&pages=180-182&date=2017&auinit1=K&auinitm=S
COPYRIGHT
  Copyright 2018 Medline is the source for the citation and abstract of this 
record.

RECORD 173
TITLE
  Open repair of chronic thoracic and thoracoabdominal aortic dissection using 
deep hypothermia and circulatory arrest
AUTHOR NAMES
  Corvera J.; Copeland H.; Blitzer D.; Hicks A.; Manghelli J.; Hess P.; Fehrenbacher J.
AUTHOR ADDRESSES
  (Corvera J., jcorvera@iuhealth.org; Copeland H.; Blitzer D.; Hicks A.; 
Manghelli J.; Hess P.; Fehrenbacher J.) Division of Cardiothoracic Surgery, 
Indiana University School of Medicine, Indiana University Health, 
Indianapolis, United States.
CORRESPONDENCE ADDRESS
  J. Corvera, Indiana University School of Medicine, Director of Thoracic 
Vascular Surgery, Indiana University Health, 1801 N. Senate Blvd, Suite 
3300, Indianapolis, United States. Email: jcorvera@iuhealth.org
AiP/IP ENTRY DATE
  2017-04-24
FULL RECORD ENTRY DATE
  2017-10-12
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2017) 154:2 (389-395). Date 
of Publication: 1 Aug 2017
VOLUME
  154
ISSUE
  2
FIRST PAGE
  389
LAST PAGE
  395
DATE OF PUBLICATION
  1 Aug 2017
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Background Chronic dissection of the thoracic and thoracoabdominal aorta as 
sequela of a prior type A or B dissection is a challenging problem that 
requires close radiographic surveillance and prompt operative intervention 
in the presence of symptoms or aneurysm formation. Open repair of chronic 
thoracic and thoracoabdominal aortic dissection using deep hypothermia has 
been our preferred method to treat this complex pathology. The advantages of 
this technique include organ and spinal cord protection, the flexibility to 
extend the repair proximally into the arch, and the ability to limit 
ischemia to all vascular beds. Methods Open repair of arch by left 
thoracotomy and descending thoracic and thoracoabdominal aortic pathology 
using deep hypothermia was performed in 664 patients from 1995 to 2015. A 
subset of this cohort had chronic thoracoabdominal aortic dissection (n = 
196). All nonemergency cases received coronary angiography and 
echocardiography preoperatively. Significant coronary artery disease or 
severe aortic insufficiency was addressed before repair of the chronic 
dissection. In recent years, lumbar drains were placed preoperatively in the 
most extensive repairs (extents II and III). Important intercostal arteries 
from T8 to L1 were revascularized with smaller-diameter looped grafts. 
Multibranched grafts for the visceral segment have been preferred in recent 
years. Results Mean age of patients was 58 ± 14 years. Men comprised 74% of 
the cohort. Aortopathy was confirmed in 18% of the cohort. Prior thoracic 
aortic repair occurred in 57% of patients, and prior abdominal aortic repair 
occurred in 14% of patients. Prior type A aortic dissection occurred in 44% 
of patients, and prior type B occurred in 56% of patients. Operative 
mortality was 3.6%, permanent spinal cord ischemia occurred in 2.6% of 
patients, permanent hemodialysis occurred in 0% of patients, and permanent 
stroke occurred in 1% of patients. Reexploration for bleeding was 5.1%, and 
respiratory failure requiring tracheostomy occurred in 2.6%. Postoperative 
length of stay was 11.9 ± 9.7 days. Reintervention for pseudoaneurysm or 
growth of a distal aneurysm was 6.9%. The 1-, 5-, and 10-year survivals were 
93%, 79%, and 57%, respectively. Conclusions Open repair of chronic thoracic 
and thoracoabdominal aortic dissection using deep hypothermia and 
circulatory arrest has low morbidity and mortality. The need for 
reintervention is low, and long-term survival is excellent. We believe that 
open repair continues to be the gold standard in patients who are suitable 
candidates for surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); chronic disease (surgery); descending aortic surgery; heart arrest; hypothermia; thoracic aortic dissection (surgery); thoracic aortic surgery; thoracoabdominal aortic dissection (surgery); thoracotomy; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication); adult; aortic reconstruction; aortic regurgitation; article; cardiopulmonary bypass; cerebrovascular accident (complication); computer assisted tomography; coronary angiography; coronary artery disease; echocardiography; false aneurysm; female; follow up; hemodialysis; hospitalization; human; length of stay; long term survival; major clinical study; male; middle aged; paraplegia (complication); pneumonia (complication); postoperative hemorrhage (complication); priority journal; reoperation; respiratory failure; spinal cord ischemia; surgical mortality; survival; thoracoabdominal aorta aneurysm (surgery); tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Physiology (2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170282927
PUI
  L615443193
DOI
  10.1016/j.jtcvs.2017.03.020
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2017.03.020
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2017.03.020&atitle=Open+repair+of+chronic+thoracic+and+thoracoabdominal+aortic+dissection+using+deep+hypothermia+and+circulatory+arrest&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=154&issue=2&spage=389&epage=395&aulast=Corvera&aufirst=Joel&auinit=J.&aufull=Corvera+J.&coden=JTCSA&isbn=&pages=389-395&date=2017&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 174
TITLE
  Adaptation of speech valve in child with spinal cord injury
AUTHOR NAMES
  Da Silva Freitas J.; Da Cunha Pereira G.; Dos Santos A.C.K.; Kurtz L.; De Oliveira A.C.; Garcez L.W.
AUTHOR ADDRESSES
  (Da Silva Freitas J.; Da Cunha Pereira G.; Dos Santos A.C.K.; Kurtz L.; De 
Oliveira A.C.; Garcez L.W.) Grupo Hospitalar Conceição, Brazil.
CORRESPONDENCE ADDRESS
  J. Da Silva Freitas, Grupo Hospitalar Conceição, Brazil.
FULL RECORD ENTRY DATE
  2018-08-17
SOURCE
  International Archives of Otorhinolaryngology (2017) 21 Supplement 2 (S108). 
Date of Publication: 1 Aug 2017
VOLUME
  21
FIRST PAGE
  S108
DATE OF PUBLICATION
  1 Aug 2017
CONFERENCE NAME
  16th Congress of Otorhinolaryngology Foundation
CONFERENCE LOCATION
  Sao Paulo - SP, Brazil
CONFERENCE DATE
  2017-08-31 to 2017-09-02
ISSN
  1809-4864
BOOK PUBLISHER
  Georg Thieme Verlag
ABSTRACT
  Introduction: Spinal cord trauma is an external caused injury in the spinal 
cord and leads to motor and sensory alterations. Tetraplegia comes up from 
lesions between the first and seventh cervical vertebrae. The speech valve 
allows the air to be exhaled by the upper airways, this mechanism allows the 
oral communication of the tracheostomized patient, facilitates the 
management of secretions through the training of the laryngeal function, 
reducing the need for aspirations. Objective: To report the process of 
speech valve adaptation in a quadriplegic child due to spinal cord trauma. 
Resumed report: Child with one year and eight months, quadriplegic due to 
spindle trauma, fracture in C2-C5 by stretching, with tracheostomy, using 
invasive mechanical ventilation.In process of adaptation with passy muir 
valve, model 007 for mechanical ventilation. That was realized seven 
training sessions with deflated cuff and peep equal to 0, showed lack of 
oxygenation and signs of air entrapment. After modified patient sitting 
position, using rigid vest and parameters of ventilator changed to peep of 
3, greater expiratory time and lower respiratory rate, it allows the 
tolerance of the valve for a longer time, no longer showing signs of air 
entrapment. Conclusion: During the period using the valve, can be observed 
vocalizations of monosyllables and disyllabic, better handling of cough and 
the swallowing of secretions and saliva. The adaptation of this device aims 
to contribute to an improvement in breathing, phonation and deglutition 
mechanisms, directly impacting in the life quality of the patient.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; voice prosthesis; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; aspiration; bodily secretions; breathing rate; case report; cervical vertebra; child; clinical article; conference abstract; coughing; female; fracture; human; male; oxygenation; phonation; pneumatic cuff; quadriplegia; quality of life; salivation; swallowing; tracheostomy; upper respiratory tract; ventilator; vocalization; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623447246
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18094864&id=doi:&atitle=Adaptation+of+speech+valve+in+child+with+spinal+cord+injury&stitle=Int.+Arch.+Otorhinolaryngol.&title=International+Archives+of+Otorhinolaryngology&volume=21&issue=&spage=S108&epage=&aulast=Da+Silva+Freitas&aufirst=Jordana&auinit=J.&aufull=Da+Silva+Freitas+J.&coden=&isbn=&pages=S108-&date=2017&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 175
TITLE
  Oral ephedrine is useful to wean patients off long term parenteral 
vasopressors after cervical spinal cord injury
AUTHOR NAMES
  Khan M.F.; Siddiqui K.M.; Asghar M.A.; Ullah H.
AUTHOR ADDRESSES
  (Khan M.F.; Siddiqui K.M., khalid.siddiqui@aku.edu; Asghar M.A.; Ullah H.) 
Department of Anesthesiology, Aga Khan University Hospital, Stadium Road, 
P.O. Box 3500, Karachi, Pakistan.
CORRESPONDENCE ADDRESS
  K.M. Siddiqui, Department of Anesthesiology, Aga Khan University Hospital, 
Stadium Road, P.O. Box 3500, Karachi, Pakistan. Email: 
khalid.siddiqui@aku.edu
AiP/IP ENTRY DATE
  2017-11-27
FULL RECORD ENTRY DATE
  2017-12-01
SOURCE
  Anaesthesia, Pain and Intensive Care (2017) 21:3 (380-382). Date of 
Publication: 1 Jul 2017
VOLUME
  21
ISSUE
  3
FIRST PAGE
  380
LAST PAGE
  382
DATE OF PUBLICATION
  1 Jul 2017
ISSN
  1607-8322
BOOK PUBLISHER
  Faculty of Anaesthesia, Pain and Intensive Care, AFMS, 
tariqhayatkhan@hotmail.com
ABSTRACT
  Traumatic spinal cord injury (SCI) in young adults not only increases the 
risk of mortality but more commonly it complicates with life-long 
disability. Cervical SCI patients are particularly susceptible and sensitive 
to phases of cardiovascular instability and respiratory failure directly 
consequential from their injuries. Furthermore, long term vasopressor 
requirement is not uncommon though weaning from parenteral vasopressor is a 
challenge. We document a case of the use of oral ephedrine, which we used to 
wean our patient from parenteral vasopressors. Oral ephedrine can be an 
appropriate option to get rid of long term use of infusion of vasopressor.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ephedrine (oral drug administration); hypertensive factor; 
EMTREE DRUG INDEX TERMS
  dopamine; noradrenalin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; autonomic dysfunction; blood pressure; case report; clinical article; comminuted fracture; crystalloid; disease severity; endotracheal tube; fluid resuscitation; gunshot injury; heart rate; hematopneumothorax; human; hypotension; intensive care; intensive care unit; male; mean arterial pressure; sinus arrhythmia; sweating; tracheostomy; 
CAS REGISTRY NUMBERS
  dopamine (51-61-6, 62-31-7)
  ephedrine (299-42-3, 50-98-6)
  noradrenalin (1407-84-7, 51-41-2)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170821314
PUI
  L619363363
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16078322&id=doi:&atitle=Oral+ephedrine+is+useful+to+wean+patients+off+long+term+parenteral+vasopressors+after+cervical+spinal+cord+injury&stitle=Anaesth.+Pain+Intensive+Care&title=Anaesthesia%2C+Pain+and+Intensive+Care&volume=21&issue=3&spage=380&epage=382&aulast=Khan&aufirst=Muhammad+Faisal&auinit=M.F.&aufull=Khan+M.F.&coden=&isbn=&pages=380-382&date=2017&auinit1=M&auinitm=F
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 176
TITLE
  Locked-in syndrome: Traumatic anatomy of a rare condition
AUTHOR NAMES
  Maynard W.; Sewell M.; Laherty R.
AUTHOR ADDRESSES
  (Maynard W.) St. George's Hospital, London, United Kingdom.
(Sewell M.) James Cook University Hospital, Middlesbrough, United Kingdom.
(Laherty R.) Princess Alexandra Hospital, Brisbane, Australia.
CORRESPONDENCE ADDRESS
  W. Maynard, St. George's Hospital, London, United Kingdom.
FULL RECORD ENTRY DATE
  2017-06-28
SOURCE
  Clinical Anatomy (2017) 30:5 (658-659). Date of Publication: 1 Jul 2017
VOLUME
  30
ISSUE
  5
FIRST PAGE
  658
LAST PAGE
  659
DATE OF PUBLICATION
  1 Jul 2017
CONFERENCE NAME
  Summer Meeting of the British Association of Clinical Anatomists 2016
CONFERENCE LOCATION
  Brighton, United Kingdom
CONFERENCE DATE
  2016-07-20 to 2016-07-20
ISSN
  1098-2353
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  A 45-year-old normally fit and well female was involved in a highspeed road 
traffic accident. At the scene she was hypotensive, tachycardic and had a 
Glasgow Coma Score of 3/15. She was not moving and had sluggish dilated 
pupils. She was taken to the emergency department, resuscitated and 
underwent imaging. Ct-scanning of the head, neck, chest, abdomen and pelvis 
was performed which showed an active abdominal bleed from the superior 
mesenteric artery close to its origin. Additional injuries included bony 
disruption at the craniocervical junction and a subarachnoid haemorrhage. 
The patient went to theatre for a trauma laparotomy to ligate the bleeding 
superior mesenteric artery. Following haemorrhage control, the patient 
continued to demonstrate labile cardiorespiratory function (blood pressure 
varied between 50-180 mm Hg systolic). It was felt this was due to possible 
brainstem compression from the occipito-cervical dislocation which had 
originally been shown on CT. The patient underwent occipito-cervical fusion 
and decompression and the patient's haemodynamic status normalised. The 
patient required a tracheostomy for long-term mechanical ventilation; 
remained quadriplegic and lost the ability to speak or swallow. MRI of the 
cervical spine showed significant brainstem and proximal spinal cord oedema. 
Eye movements to command and voice were preserved and a diagnosis of 
locked-in syndrome was made. There was no neurological improvement at 6 
months. Locked in syndrome following traumatic occipito-cervical dislocation 
is rare. Clinicians need to be aware of this potential diagnosis as a cause 
of refractory haemodynamic instability in the trauma setting and to inform 
decision making regarding future care.
EMTREE DRUG INDEX TERMS
  antihypertensive agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anatomy; locked in syndrome; 
EMTREE MEDICAL INDEX TERMS
  accident; adult; blood pressure; brain stem; cervical spine dislocation; compression; controlled study; decision making; decompression; diagnosis; edema; emergency ward; eye movement; Glasgow coma scale; head; human; laparotomy; middle aged; mydriasis; nuclear magnetic resonance imaging; pelvis; spinal cord; subarachnoid hemorrhage; superior mesenteric artery; tachycardia; thorax; tracheostomy; traffic; voice; x-ray computed tomography; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L616934566
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10982353&id=doi:&atitle=Locked-in+syndrome%3A+Traumatic+anatomy+of+a+rare+condition&stitle=Clin.+Anat.&title=Clinical+Anatomy&volume=30&issue=5&spage=658&epage=659&aulast=Maynard&aufirst=William&auinit=W.&aufull=Maynard+W.&coden=&isbn=&pages=658-659&date=2017&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 177
TITLE
  Traumatic vertebral and carotid artery dissections related to motor vehicle 
accidents-injury characteristics and outcomes from a national inpatient 
sample
AUTHOR NAMES
  Khatri R.; Afzal M.R.; Qureshi M.A.; Kassar D.; Rodriguez G.J.; Cruz-Flores S.; Maud A.
AUTHOR ADDRESSES
  (Khatri R.; Afzal M.R.; Qureshi M.A.; Kassar D.; Rodriguez G.J.; Cruz-Flores 
S.; Maud A.) Department of Neurology, Texas Tech Hospital, El Paso, United 
States.
CORRESPONDENCE ADDRESS
  R. Khatri, Department of Neurology, Texas Tech Hospital, El Paso, United 
States.
FULL RECORD ENTRY DATE
  2017-12-21
SOURCE
  Cerebrovascular Diseases (2017) 43 Supplement 1 (52). Date of Publication: 1 
Jul 2017
VOLUME
  43
FIRST PAGE
  52
DATE OF PUBLICATION
  1 Jul 2017
CONFERENCE NAME
  26th European Stroke Conference
CONFERENCE LOCATION
  Berlin, Germany
CONFERENCE DATE
  2017-05-24 to 2017-05-26
ISSN
  1421-9786
BOOK PUBLISHER
  S. Karger AG
ABSTRACT
  Background: Carotid and vertebral artery dissections are relatively common 
causes of ischemic stroke. Comparative analysis between these two entities 
related to motor vehicle trauma at the national level is not well studied. 
Objective: To compare patterns of injury and in-hospital outcomes in motor 
vehicle related traumatic carotid versus vertebral artery dissections at 
national level. Methods: A retrospective study was conducted using a 
national database (years 20011 to 2014). Patients with a principal diagnosis 
of carotid dissection (ICD9 = 443.21) or vertebral dissections (ICD9 = 
443.24) were identified. Baseline characteristics, comorbidities, 
in-hospital complications, in-hospital procedures, length of stay, hospital 
charges, disability and mortality were compared between the two groups. 
Results: A total of 2969 patients had either carotid (n= 1300,44%>) or 
vertebral (n= 1669, 56 %>) artery dissection during the study period. 
Patients with vertebral artery dissections were older (mean ±SD: 46.4 ±19.4 
versus 38.2 ±16.8, p = 0.01) and had more vascular risk factors 
(hypertension, diabetes mellitus, atrial fibrillation, dyslipidemia and 
nicotine dependence). There was no statistically significant difference in 
the rate of ischemic stroke (22% carotid vs 16.6 % vertebral, p 0.1052). 
Vertebral artery dissection patients were more commonly associated with 
(83%) fractures of cervical vertebrae either without spinal cord injury 
(63.5%>) or with spinal cord injury (16.5%>). Carotid dissection patients 
had more traumatic subarachnoid hemorrhage (17.8% vs 11%), p 0.0206), brain 
injury (68.8%o vs 40.6%o p <.0001) and other organs involved including 
liver, spleen, intrathoracic organs and bone fractures (pelvic fracture, 
long bone fractures, multiple rib fractures, skull base fracture and facial 
bones fracture). They also had higher rates of pneumonia (11.5%o vs 5.6%o, p 
0.0093) and underwent more procedures (mechanical ventilation, gastrostomy, 
blood transfusion and tracheostomy). The length of stay was higher for 
carotid artery dissection (15.5 days vs 10.2 days p <.0001) patients with a 
higher moderate to severe disability (61.8%o vs 46.1%o), and the difference 
remained the same after adjusting for age, gender and the presence of other 
injuries (OR 1.679, CI 1.136-2.483, p 0.0096). There was no difference in 
mortality (12.0%o carotid artery dissection vs 7.8%o vertebral artery 
dissection, p 0.1100). Conclusion: Carotid artery dissection related to 
motor vehicle accidents are associated with other multiple organ injuries 
and bone fractures suggesting higher impact trauma, and they lead to higher 
moderate to severe disability compared to vertebral artery dissections. 
There is an association of vertebral artery dissection and the presence of 
vertebrae fractures.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  carotid artery injury; cervical vertebra; hospital patient; traffic accident; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; atrial fibrillation; blood transfusion; brain injury; brain ischemia; cardiovascular risk; comorbidity; complication; controlled study; diabetes mellitus; diagnosis; disability; dyslipidemia; facial bone; female; gastrostomy; gender; hospital charge; human; hypertension; ICD-9; length of stay; liver; major clinical study; male; mortality; multiple fracture; organ injury; pelvis fracture; pneumonia; retrospective study; rib fracture; skull base fracture; spinal cord injury; spleen; subarachnoid hemorrhage; tobacco dependence; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619777412
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14219786&id=doi:&atitle=Traumatic+vertebral+and+carotid+artery+dissections+related+to+motor+vehicle+accidents-injury+characteristics+and+outcomes+from+a+national+inpatient+sample&stitle=Cerebrovasc.+Dis.&title=Cerebrovascular+Diseases&volume=43&issue=&spage=52&epage=&aulast=Khatri&aufirst=R.&auinit=R.&aufull=Khatri+R.&coden=&isbn=&pages=52-&date=2017&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 178
TITLE
  Quality of life after resection of a chordoma of the mobile spine
AUTHOR NAMES
  Schwab J.H.; Janssen S.J.; Paulino Pereira N.R.; Chen Y.L.E.; Wain J.C.; DeLaney T.F.; Hornicek F.J.
AUTHOR ADDRESSES
  (Schwab J.H.; Janssen S.J., steinjanssen@gmail.com; Paulino Pereira N.R.; 
Chen Y.L.E.; Wain J.C.; DeLaney T.F.; Hornicek F.J.) Massachusetts General 
Hospital, Harvard Medical School, 55 Fruit Street, Boston, United States.
(Hornicek F.J.) Department of Orthopaedic Surgery, Orthopaedic Oncology 
Service, Boston, United States.
CORRESPONDENCE ADDRESS
  S.J. Janssen, Massachusetts General Hospital, Harvard Medical School, 55 
Fruit Street, Boston, United States. Email: steinjanssen@gmail.com
AiP/IP ENTRY DATE
  2017-07-06
FULL RECORD ENTRY DATE
  2017-07-11
SOURCE
  Bone and Joint Journal (2017) 99B:7 (979-986). Date of Publication: 1 Jul 
2017
VOLUME
  99B
ISSUE
  7
FIRST PAGE
  979
LAST PAGE
  986
DATE OF PUBLICATION
  1 Jul 2017
ISSN
  2049-4408 (electronic)
  2049-4394
BOOK PUBLISHER
  British Editorial Society of Bone and Joint Surgery, subs@jbjs.org.uk
ABSTRACT
  Aims The aim of the study was to compare measures of the quality of life 
(QOL) after resection of a chordoma of the mobile spine with the national 
averages in the United States and to assess which factors influenced the 
QOL, symptoms of anxiety and depression, and coping with pain 
post-operatively in these patients. Patients and Methods A total of 48 
consecutive patients who underwent resection of a primary or recurrent 
chordoma of the mobile spine between 2000 and 2015 were included. A total of 
34 patients completed a survey at least 12 months post-operatively. The 
primary outcome was the EuroQol-5 Dimensions (EQ-5D-3L) questionnaire. 
Secondary outcomes were the Patient- Reported Outcome Measurement 
Information System (PROMIS) anxiety, depression and pain interference 
questionnaires. Data which were recorded included the indication for 
surgery, the region of the tumour, the number of levels resected, the status 
of the surgical margins, re-operations, complications, neurological deficit, 
length of stay in hospital and rate of re-admission. Results The median 
EQ-5D-3L score was 0.71 (interquartile range (IQR) 0.44 to 0.79) which is 
worse than the national average in the United States of 0.85 (p < 0.001). 
Anxiety (median: 55 (IQR 49 to 61), p = 0.031) and pain (median: 61 (IQR 56 
to 68), p < 0.001) were also worse than the national average in the United 
States (50), while depression was not (median: 52 (IQR 38 to 57), p = 
0.513). Patients who underwent a primary resection had better QOL and less 
anxiety, depression and pain compared with those who underwent resection for 
recurrent or residual disease. The one- and five-year probabilities were 
0.96 and 0.74 for survival, 0.07 and 0.25 for tumour recurrence, and 0.02 
and 0.16 for developing distant metastasis. A total of 25 local 
complications occurred in 20 patients (42%), and there were 50 systemic and 
other complications in 25 patients (52%) within 90 days. Conclusion These 
patient reported outcomes and oncological and surgical outcomes can be used 
when counselling patients and to aid decision-making when planning surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chordoma (radiotherapy, surgery); mobile spine chordoma (surgery); quality of life; spinal cord decompression; spine tumor (radiotherapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal pain (complication); acute kidney failure (complication); adult; aged; anxiety disorder; article; assessment of humans; bone allograft; cancer patient; cancer radiotherapy; cancer surgery; clinical article; clinical assessment; compartment syndrome (complication); controlled study; coping behavior; decubitus (complication); deep vein thrombosis (complication); depression; distant metastasis (complication, surgery); dural tear (complication); dysphagia (complication); dyspnea (complication); European Quality of Life 5 Dimensions questionnaire; female; femoral shaft; femoral shaft allograft; fever (complication); fibula; fibula graft; fibular allograft; health survey; heart infarction (complication); hospital readmission; hospitalization; human; humeral shaft; humeral shaft allograft; hygroma (complication); intubation; length of stay; lung embolism (complication); male; medical information system; meninx disorder (complication); middle aged; minimal residual disease (surgery); neurogenic bladder (complication); neurologic disease (complication); nutritional deficiency (complication); outcome assessment; overall survival; paraplegia (complication); Patient Reported Outcome Measurement Information System; patient-reported outcome; pedicle screw (adverse device effect); pedicle screw malposition (complication); peripheral neuropathy (complication); pleura effusion (complication); pneumonia (complication); postoperative complication; postoperative delirium (complication); postoperative ileus (complication); postoperative nausea and vomiting (complication); postoperative pain (complication); postoperative period; priority journal; prosthesis complication (complication); prosthesis loosening (complication); pyelonephritis (complication); pyrexia idiopathica (complication); respiratory failure (complication); risk factor; serotonin syndrome (complication); spine stabilization; surgical infection (complication); surgical margin; surgical patient; symptom; tracheostomy; tumor recurrence; United States; ureter stone (complication); urinary tract infection (complication); urosepsis (complication); vocal cord paralysis (complication); 
EMBASE CLASSIFICATIONS
  Cancer (16)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170469492
MEDLINE PMID
  28663407 (http://www.ncbi.nlm.nih.gov/pubmed/28663407)
PUI
  L617069268
DOI
  10.1302/0301-620X.99B7.BJJ-2016-1126.R1
FULL TEXT LINK
  http://dx.doi.org/10.1302/0301-620X.99B7.BJJ-2016-1126.R1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20494408&id=doi:10.1302%2F0301-620X.99B7.BJJ-2016-1126.R1&atitle=Quality+of+life+after+resection+of+a+chordoma+of+the+mobile+spine&stitle=Bone+Jt.+J.&title=Bone+and+Joint+Journal&volume=99B&issue=7&spage=979&epage=986&aulast=Schwab&aufirst=J.H.&auinit=J.H.&aufull=Schwab+J.H.&coden=&isbn=&pages=979-986&date=2017&auinit1=J&auinitm=H
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 179
TITLE
  Experience of Sun′s procedure for chronic type B dissection with aortic arch 
involvement
AUTHOR NAMES
  Qi R.; Zhu J.; Chen L.; Li C.; Qiao Z.; Cheng L.; Ge Y.; Hu H.; Xia Y.; Xing X.; Zheng T.; Liu Y.; Sun L.
AUTHOR ADDRESSES
  (Qi R.; Zhu J., anzhenzjm@163.com; Chen L.; Li C.; Qiao Z.; Cheng L.; Ge Y.; 
Hu H.; Xia Y.; Xing X.; Zheng T.; Liu Y.; Sun L.) Cardiovascular Surgery 
Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Aortic 
Disease Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases, 
Beijing, China.
CORRESPONDENCE ADDRESS
  J. Zhu, Cardiovascular Surgery Center, Beijing Anzhen Hospital, Capital 
Medical University, Beijing Aortic Disease Center, Beijing Institute of 
Heart, Lung and Blood Vessel Diseases, Beijing, China. Email: 
anzhenzjm@163.com
AiP/IP ENTRY DATE
  2018-08-07
FULL RECORD ENTRY DATE
  2018-08-08
SOURCE
  National Medical Journal of China (2017) 97:24 (1867-1870). Date of 
Publication: 27 Jun 2017
VOLUME
  97
ISSUE
  24
FIRST PAGE
  1867
LAST PAGE
  1870
DATE OF PUBLICATION
  27 Jun 2017
ISSN
  0376-2491
BOOK PUBLISHER
  Chinese Medical Association
ABSTRACT
  Objective: To study the surgical treatment of chronic type B dissection with 
aortic arch involvement using Sun′s procedure. Methods: Between February 
2009 and December 2015, 29 patients [20 males, 9 females, with a mean age of 
(41±12) years, range 24-64 years] with type B dissection with aortic arch 
involvement underwent Sun′s procedure. Sixteen patient had a history of 
hypertension. Marfan syndrome was observed in 9 cases, coronary artery 
disease in 3 cases, mitral regurgitation in 3 patients, cerebrovascular 
disease in one patient. Twenty-two patients suffered proximal aortic arch 
disease, 4 cases experienced history of aortic root procedure and 2 subjects 
had history of pregnancy. Four patients had aortic arch malformation. 
Results: One case suffered from massive cerebral infarction after surgery 
and died in another hospital. Concomitant procedures included mitral valve 
replacement in 3 cases, coronary artery bypass grafting in 3 patients, 
reconstruction of the right aberrant subclavian artery in one patient. 
Ventilator support exceeding 24 hours obseved in 2 patients. One of them 
recieved continuous renal replacement therapy and recovered before 
discharge. Spinal cord injury was obseved in one case, brain infarction in 
one patient and pericardial drainage in one case. Two patients required 
tracheotomy. During 12-94 (43±23) months′ follow-up, thoracoabdominal aortic 
replacment was performed in 4 patients, thoracic endovascular aortic repair 
(TEVAR) in 2 subjects and repair of perivalvular leakage in one patient. 
Conclusions: Sun′s procedure obtained satisfactory results in patients with 
chronic type B dissection with aortic arch involvement. Concomitant repair 
of proximal aortic arch lesions and distal type B dissection can be adopted 
using Sun′s procedure.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic arch; aortic disease; aortic dissection (surgery); surgical technique; 
EMTREE MEDICAL INDEX TERMS
  adult; aortic arch anomaly; aortic root surgery; artery reconstruction; article; artificial ventilation; brain infarction (complication); cerebrovascular disease; clinical article; coronary artery bypass graft; coronary artery disease (surgery); endovascular aneurysm repair; female; follow up; hospital discharge; human; hypertension; male; Marfan syndrome; medical history; mitral valve regurgitation (surgery); mitral valve replacement; personal experience; renal replacement therapy; subclavian artery; thoracic aortic surgery; tracheotomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  English, Chinese
EMBASE ACCESSION NUMBER
  20180538028
MEDLINE PMID
  28648010 (http://www.ncbi.nlm.nih.gov/pubmed/28648010)
PUI
  L623284292
DOI
  10.3760/cma.j.issn.0376-2491.2017.24.005
FULL TEXT LINK
  http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2017.24.005
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03762491&id=doi:10.3760%2Fcma.j.issn.0376-2491.2017.24.005&atitle=Experience+of+Sun%E2%80%B2s+procedure+for+chronic+type+B+dissection+with+aortic+arch+involvement&stitle=Nat.+Med.+J.+China&title=National+Medical+Journal+of+China&volume=97&issue=24&spage=1867&epage=1870&aulast=Qi&aufirst=Ruidong&auinit=R.&aufull=Qi+R.&coden=&isbn=&pages=1867-1870&date=2017&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 180
TITLE
  Successful tracheostomy decannulation after complete or sensory incomplete 
cervical spinal cord injury
AUTHOR NAMES
  Kim D.H.; Kang S.W.; Choi W.A.; Oh H.J.
AUTHOR ADDRESSES
  (Kim D.H.) Department of Rehabilitation Medicine, Kangdong Sacred Heart 
Hospital, Hallym University College of Medicine, Seoul, South Korea.
(Kang S.W., kswoong@yuhs.ac; Choi W.A.; Oh H.J.) Department of 
Rehabilitation Medicine, Pulmonary Rehabilitation Center, Rehabilitation 
Institute of Neuromuscular Disease, 211 Eunju-ro, Gangnam-gu, Seoul, South 
Korea.
CORRESPONDENCE ADDRESS
  S.W. Kang, Department of Rehabilitation Medicine, Pulmonary Rehabilitation 
Center, Rehabilitation Institute of Neuromuscular Disease, 211 Eunju-ro, 
Gangnam-gu, Seoul, South Korea. Email: kswoong@yuhs.ac
AiP/IP ENTRY DATE
  2017-02-03
FULL RECORD ENTRY DATE
  2017-06-13
SOURCE
  Spinal Cord (2017) 55:6 (601-605). Date of Publication: 1 Jun 2017
VOLUME
  55
ISSUE
  6
FIRST PAGE
  601
LAST PAGE
  605
DATE OF PUBLICATION
  1 Jun 2017
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study Design: Retrospective study. Objectives: To report the successful 
tracheostomy decannulation/extubation in cervical spinal cord injury (C-SCI) 
patients. Setting: Tertiary university hospital, pulmonary rehabilitation 
center. Methods: Complete or sensory incomplete C-SCI patients who had 
received invasive acute phase respiratory management, and succeeded in 
decannulation/extubation became candidates of this study. Retrospective 
review was conducted on the transitions of the respiratory status. Results: 
Sixty-two patients (M: 55, F: 7) were identified. Traumatic etiologies 
accounted for 93.5%, and mean onset age was 47.6±15.8 years. Sixty patients 
(96.8%) had undergone tracheostomy and the other two received endotracheal 
intubation during acute phase. All patients succeeded in 
decannulation/extubation after employing mechanically assisted coughing and 
noninvasive mechanical ventilation (NIV). Mean time since tracheostomy to 
decannulation was 7.0±14.5 months. Of the 60 tracheostomized patients, 12 
succeeded in decannulation without applying long-term NIV, 31 switched to 
continuous NIV after decannulation. Fifteen patients totally weaned off from 
ventilators after NIV. Two patients who once succeeded in decannulation were 
re-tracheostomized. For the 31 patients with continuous NIV, mean hours of 
daily need for ventilatory support had reduced from 15.3±8.0 to 5.7±5.7 h at 
final follow-ups. Conclusion: Complete or sensory incomplete C-SCI patients, 
even with high neurological level can be successfully decannulated through 
NIV and aggressive use of mechanically assisted coughing. Undesirable 
tracheostomy can be avoided by employing the noninvasive respiratory 
management.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cannulation; cervical spinal cord injury (rehabilitation, surgery, therapy); decannulation; extubation; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; airway obstruction (complication); American Spinal Injury Association impairment scale; article; artificial ventilation; comorbidity; coughing; decubitus; depression; endotracheal intubation; female; heterotopic ossification; human; hypercapnia (complication); intensive care unit; lung function; major clinical study; male; non invasive procedure; onset age; pleura effusion; pneumonia; positive end expiratory pressure; priority journal; pulmonary rehabilitation; respiratory care; retrospective study; sleep disordered breathing (complication); tracheostomy tube; urinary tract infection; ventilator weaning; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170081348
MEDLINE PMID
  28117330 (http://www.ncbi.nlm.nih.gov/pubmed/28117330)
PUI
  L614244170
DOI
  10.1038/sc.2016.194
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2016.194
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fsc.2016.194&atitle=Successful+tracheostomy+decannulation+after+complete+or+sensory+incomplete+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=55&issue=6&spage=601&epage=605&aulast=Kim&aufirst=D.H.&auinit=D.H.&aufull=Kim+D.H.&coden=SPCOF&isbn=&pages=601-605&date=2017&auinit1=D&auinitm=H
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 181
TITLE
  Implementation of a respiratory rehabilitation protocol: weaning from the 
ventilator and tracheostomy in difficult-to-wean patients with spinal cord 
injury
AUTHOR NAMES
  Gundogdu I.; Ozturk E.A.; Umay E.; Karaahmet O.Z.; Unlu E.; Cakci A.
AUTHOR ADDRESSES
  (Gundogdu I.; Ozturk E.A.; Umay E.; Karaahmet O.Z.; Unlu E.; Cakci A.) a 
Physical Therapy and Rehabilitation Clinic, Ministry of Health Ankara 
Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey
FULL RECORD ENTRY DATE
  2018-03-13
SOURCE
  Disability and rehabilitation (2017) 39:12 (1162-1170). Date of Publication: 
1 Jun 2017
VOLUME
  39
ISSUE
  12
FIRST PAGE
  1162
LAST PAGE
  1170
DATE OF PUBLICATION
  1 Jun 2017
ISSN
  1464-5165 (electronic)
ABSTRACT
  PURPOSE: Following repeated weaning failures in acute care services, spinal 
cord injury (SCI) patients who require prolonged mechanical ventilation and 
tracheostomy are discharged to their homes or skilled nursing facilities, 
with a portable mechanical ventilator (MV) and/or tracheostomy tube (TT) 
with excess risk of complications, high cost and low quality of life. We 
hypothesized that many difficult-to-wean patients with cervical SCI can be 
successfully managed in a rehabilitation clinic. The aim of our study was to 
develop a respiratory rehabilitation, MV weaning and TT decannulation 
protocol and to evaluate the effectiveness of this protocol in tetraplegic 
patients.METHODS: A multidisciplinary and multifaceted protocol, including 
respiratory assessment and management themes, was developed and performed 
based on the findings from other studies in the literature. Tetraplegic 
patients with the diagnosis of difficult-to-wean, who were admitted to the 
rehabilitation clinic after having been discharged from the intensive care 
unit to their home with home-type MV and/or TT, were included in this 
prospective observational study.RESULTS: The respiratory rehabilitation 
protocol was applied to 35 tetraplegic patients (10 home-type MV and 
tracheostomy-dependent, and 25 tracheostomized patients) with C1-C7 ASIA 
impairment scale grade A, B, and C injuries. Seven out of 10 patients 
successfully weaned from MV and 30 of 35 patients were decannulated. Four 
patients were referred for diaphragm pace stimulation and tracheal stenosis 
surgery. The mean durations of MV weaning and decannulation were 37 and 31 
days, respectively.CONCLUSIONS: A multifaceted, multidisciplinary 
respiratory management program can change the process of care used for 
difficult-to-wean patients with SCI. Implications for rehabilitation 
Findings from this study indicate the significance of a multidimensional 
evaluation of any reversible factors for prolonged MV- and/or TT-dependent 
SCI patients. Thus, rehabilitation specialists should take this into 
consideration and should provide the appropriate amount of time to these 
patients. The proposed protocol of respiratory rehabilitation for MV- and/or 
TT-dependent SCI patients shows promising results in terms of changing the 
care used for these patients. Successful implementation of a respiratory 
rehabilitation and weaning protocol is dependent on careful planning and 
detailed communication between the rehabilitation specialist and intensivist 
during the respiratory rehabilitation process. Because many of the so-called 
difficult- or impossible-to-wean patients were successfully weaned from MV 
and TT in the PMR clinic, the need for such an outlet for countries without 
specialized centers is supported.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  clinical protocol; pathophysiology; tracheostomy; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; female; home care; hospital discharge; human; male; middle aged; prospective study; quality of life; spinal cord injury (rehabilitation); standards; tertiary care center; young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  27339104 (http://www.ncbi.nlm.nih.gov/pubmed/27339104)
PUI
  L621121608
DOI
  10.1080/09638288.2016.1189607
FULL TEXT LINK
  http://dx.doi.org/10.1080/09638288.2016.1189607
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14645165&id=doi:10.1080%2F09638288.2016.1189607&atitle=Implementation+of+a+respiratory+rehabilitation+protocol%3A+weaning+from+the+ventilator+and+tracheostomy+in+difficult-to-wean+patients+with+spinal+cord+injury&stitle=Disabil+Rehabil&title=Disability+and+rehabilitation&volume=39&issue=12&spage=1162&epage=1170&aulast=Gundogdu&aufirst=Ibrahim&auinit=I.&aufull=Gundogdu+I.&coden=&isbn=&pages=1162-1170&date=2017&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2018 Medline is the source for the citation and abstract of this 
record.

RECORD 182
TITLE
  Pulmonary outcomes following specialized respiratory management for acute 
cervical spinal cord injury: A retrospective analysis
AUTHOR NAMES
  Zakrasek E.C.; Nielson J.L.; Kosarchuk J.J.; Crew J.D.; Ferguson A.R.; Mckenna S.L.
AUTHOR ADDRESSES
  (Zakrasek E.C.; Crew J.D.) Department of Orthopedic Surgery, Stanford 
Hospitals and Clinics, Palo Alto, United States.
(Nielson J.L.; Ferguson A.R.; Mckenna S.L., Stephen.Mckenna@hhs.sccgov.org) 
Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, 
University of California, San Francisco, School of Medicine, 751 South 
Bascom Avenue, San Jose, United States.
(Kosarchuk J.J.; Crew J.D.) Department of Physical Medicine and 
Rehabilitation, Santa Clara Valley Medical Center, San Jose, United States.
(Ferguson A.R.) San Francisco VA Medical Center, San Francisco, United 
States.
(Mckenna S.L., Stephen.Mckenna@hhs.sccgov.org) Department of Neurosurgery, 
Stanford University, School of Medicine, Stanford, United States.
CORRESPONDENCE ADDRESS
  S.L. Mckenna, Brain and Spinal Injury Center, Zuckerberg San Francisco 
General Hospital, University of California, San Francisco, School of 
Medicine, 751 South Bascom Avenue, San Jose, United States. Email: 
Stephen.Mckenna@hhs.sccgov.org
AiP/IP ENTRY DATE
  2017-02-24
FULL RECORD ENTRY DATE
  2017-06-13
SOURCE
  Spinal Cord (2017) 55:6 (559-565). Date of Publication: 1 Jun 2017
VOLUME
  55
ISSUE
  6
FIRST PAGE
  559
LAST PAGE
  565
DATE OF PUBLICATION
  1 Jun 2017
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study Design: Retrospective analysis. Objectives: To identify multivariate 
interactions of respiratory function that are sensitive to spinal cord 
injury level and pharmacological treatment to promote strategies that 
increase successful liberation from mechanical ventilation. Setting: United 
States regional spinal cord injury (SCI) treatment center. Methods: 
Retrospective chart review of patients consecutively admitted to Santa Clara 
Valley Medical Center between May 2013 and December 2014 for ventilator 
weaning with C1-C5 American Spinal Injury Association Impairment Scale (AIS) 
A or B SCI, <3 months from injury and who had a tracheostomy in place. A 
nonlinear, categorical principal component analysis (NL-PCA) was performed 
to test the multivariate interaction of respiratory outcomes from patients 
(N=36) being weaned off ventilator support after acute SCI with (N=15) or 
without (N=21) theophylline treatment. Results: In total, 36 patients met 
inclusion criteria (2 C1, 5 C2, 11 C3, 14 C4 and 4 C5). The NL-PCA returned 
three independent components that accounted for 95% of the variance in the 
data set. Multivariate general linear models hypothesis tests revealed a 
significant syndromic interaction between theophylline treatment and SCI 
level (Wilks' Lambda, P=0.028, F (12,64)=2.116, ' • 2 =0.256, 1-β=0.838), 
with post hoc testing demonstrating a significant interaction on PC1, 
explained by a positive correlation between improved forced vital capacity 
and time it took to reach 16 h of ventilator-free breathing. Thirty-three 
patients (92%) achieved 16 h of ventilator-free breathing (VFB) and 30 
patients (83%) achieved 24 h of VFB. Conclusions: We suspect that some 
portion of the high success rate of ventilator weaning may be attributable 
to theophylline use in higher cervical SCI, in addition to our aggressive 
regimen of high volume ventilation, medication optimization and pulmonary 
toilet (positive pressure treatments and mechanical 
insufflation-exsufflation).
EMTREE DRUG INDEX TERMS
  theophylline (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; respiratory failure (drug therapy, drug therapy, therapy); ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; American Spinal Injury Association impairment scale; article; artificial ventilation; clinical article; female; forced vital capacity; human; male; mechanical ventilator; medical record review; middle aged; positive end expiratory pressure; priority journal; respiratory function; tracheostomy; 
CAS REGISTRY NUMBERS
  theophylline (58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170136177
MEDLINE PMID
  28220822 (http://www.ncbi.nlm.nih.gov/pubmed/28220822)
PUI
  L614507533
DOI
  10.1038/sc.2017.10
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2017.10
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fsc.2017.10&atitle=Pulmonary+outcomes+following+specialized+respiratory+management+for+acute+cervical+spinal+cord+injury%3A+A+retrospective+analysis&stitle=Spinal+Cord&title=Spinal+Cord&volume=55&issue=6&spage=559&epage=565&aulast=Zakrasek&aufirst=E.C.&auinit=E.C.&aufull=Zakrasek+E.C.&coden=SPCOF&isbn=&pages=559-565&date=2017&auinit1=E&auinitm=C
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 183
TITLE
  Cervicomedullary decompression through expanded endoscopic endonasal 
approach: Our clinical experience
AUTHOR NAMES
  Alkherayf F.; Agbi C.; Kilty S.; Lamothe A.
AUTHOR ADDRESSES
  (Alkherayf F.; Agbi C.; Kilty S.; Lamothe A.) Ottawa, Canada.
CORRESPONDENCE ADDRESS
  F. Alkherayf, Ottawa, Canada.
FULL RECORD ENTRY DATE
  2017-11-02
SOURCE
  Canadian Journal of Neurological Sciences (2017) 44 Supplement 2 (S16). Date 
of Publication: 1 Jun 2017
VOLUME
  44
FIRST PAGE
  S16
DATE OF PUBLICATION
  1 Jun 2017
CONFERENCE NAME
  52nd Annual Congress of the Canadian Neurological Sciences Federation
CONFERENCE LOCATION
  Victoria, BC, Canada
CONFERENCE DATE
  2017-06-20 to 2017-06-23
ISSN
  0317-1671
BOOK PUBLISHER
  Cambridge University Press
ABSTRACT
  Background: patients with ventral cervical-medullary compression require 
anterior decompression of the cervicomedullary junction. Odontoid resection 
can be accomplished through expanded endoscopic approach especially in cases 
of irreducible basilar invagination in which the pathology is situated well 
above the palatine line. Methods: We are presenting our experience at the 
Ottawa Hospital (TOH) over the last seven years in patients who underwent 
expanded endoscopic endonasal decompression of their cervicomedullary 
junction. 16 patients underwent such procedure, those patients with 
preoperative cervical instability underwent posterior fusion for 
stabilization at the same surgical setting. Follow up ranged from 9 months 
to 5 years. Results: All patients had severe symptoms of myelopathy and some 
lower cranial nerves dysfunction. All patients were extubated after recovery 
from anesthesia and allowed oral intake next day. patients demonstrated 
improvement in their symptoms and none of them required tracheostomy. 12.5% 
experienced transient velopharyngeal insufficiency. one patient had CSF leak 
which was successfully treated with lumbar drain and one patient developed 
infection from the posterior cervical fusion and required debridement. All 
patients were eventually discharged home. Postoperative imaging demonstrated 
excellent decompression of the anterior cervicomedullary junction pathology. 
Conclusions: The expanded endoscopic endonasal approach for odontoidectomy 
should be considered as a minimally invasive approach for anterior 
decompression in selected cases.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  decompression; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; child; clinical article; cranial nerve; debridement; drain; female; follow up; human; infection; liquorrhea; lumbar region; palatopharyngeal incompetence; pathology; preschool child; remission; spinal cord disease; surgery; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619001099
DOI
  10.1017/cjn.2017.94
FULL TEXT LINK
  http://dx.doi.org/10.1017/cjn.2017.94
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03171671&id=doi:10.1017%2Fcjn.2017.94&atitle=Cervicomedullary+decompression+through+expanded+endoscopic+endonasal+approach%3A+Our+clinical+experience&stitle=Can.+J.+Neurol.+Sci.&title=Canadian+Journal+of+Neurological+Sciences&volume=44&issue=&spage=S16&epage=&aulast=Alkherayf&aufirst=F.&auinit=F.&aufull=Alkherayf+F.&coden=&isbn=&pages=S16-&date=2017&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 184
TITLE
  Update on traumatic acute spinal cord injury. Part 2
ORIGINAL (NON-ENGLISH) TITLE
  Actualización en lesión medular aguda postraumática. Parte 2 Actualización 
en lesión medular aguda postraumática. Parte 2
AUTHOR NAMES
  Mourelo Fariña M.; Salvador de la Barrera S.; Montoto Marqués A.; Ferreiro Velasco M.E.; Galeiras Vázquez R.
AUTHOR ADDRESSES
  (Mourelo Fariña M.; Galeiras Vázquez R., ritagaleiras@hotmail.es) Unidad de 
Cuidados Intensivos, Complexo Hospitalario Universitario de A Coruña, A 
Coruña, Spain.
(Salvador de la Barrera S.; Montoto Marqués A.; Ferreiro Velasco M.E.) 
Unidad de Lesionados Medulares, Complexo Hospitalario Universitario de A 
Coruña, A Coruña, Spain.
(Montoto Marqués A.) Departamento de Medicina, Universidad de A Coruña, A 
Coruña, Spain.
CORRESPONDENCE ADDRESS
  R. Galeiras Vázquez, Unidad de Cuidados Intensivos, Complexo Hospitalario 
Universitario de A Coruña, A Coruña, Spain. Email: ritagaleiras@hotmail.es
AiP/IP ENTRY DATE
  2017-02-07
FULL RECORD ENTRY DATE
  2017-06-07
SOURCE
  Medicina Intensiva (2017) 41:5 (306-315). Date of Publication: 1 Jun 2017
VOLUME
  41
ISSUE
  5
FIRST PAGE
  306
LAST PAGE
  315
DATE OF PUBLICATION
  1 Jun 2017
ISSN
  1578-6749 (electronic)
  0210-5691
BOOK PUBLISHER
  Ediciones Doyma, S.L., suscripciones@doyma.es
ABSTRACT
  The aim of treatment in acute traumatic spinal cord injury is to preserve 
residual neurologic function, avoid secondary injury, and restore spinal 
alignment and stability. In this second part of the review, we describe the 
management of spinal cord injury focusing on issues related to short-term 
respiratory management, where the preservation of diaphragmatic function is 
a priority, with prediction of the duration of mechanical ventilation and 
the need for tracheostomy. Surgical assessment of spinal injuries based on 
updated criteria is discussed, taking into account that although the type of 
intervention depends on the surgical team, nowadays treatment should afford 
early spinal decompression and stabilization. Within a comprehensive 
strategy in spinal cord injury, it is essential to identify and properly 
treat patient anxiety and pain associated to spinal cord injury, as well as 
to prevent and ensure the early diagnosis of complications secondary to 
spinal cord injury (thromboembolic disease, gastrointestinal and urinary 
disorders, pressure ulcers).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; spinal cord injury (surgery); tracheostomy; traumatic acute spinal cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  anxiety; article; decubitus (complication); early diagnosis; gastrointestinal disease (complication); human; patient care; spinal cord decompression; spinal pain; spine stabilization; thromboembolism (complication); treatment duration; urinary tract disease (complication); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English, Spanish
LANGUAGE OF SUMMARY
  English, Spanish
EMBASE ACCESSION NUMBER
  20170088925
MEDLINE PMID
  28161027 (http://www.ncbi.nlm.nih.gov/pubmed/28161027)
PUI
  L614278057
DOI
  10.1016/j.medin.2016.10.014
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.medin.2016.10.014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15786749&id=doi:10.1016%2Fj.medin.2016.10.014&atitle=Update+on+traumatic+acute+spinal+cord+injury.+Part+2&stitle=Med.+Intensiva&title=Medicina+Intensiva&volume=41&issue=5&spage=306&epage=315&aulast=Mourelo+Fari%C3%B1a&aufirst=M.&auinit=M.&aufull=Mourelo+Fari%C3%B1a+M.&coden=MDINE&isbn=&pages=306-315&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 185
TITLE
  Determinants of cough effectiveness in patients with respiratory muscle 
weakness
AUTHOR NAMES
  Laghi F.; Maddipati V.; Schnell T.; Langbein W.E.; Tobin M.J.
AUTHOR ADDRESSES
  (Laghi F., flaghi@lumc.edu; Maddipati V., maddipativ15@ecu.edu; Schnell T., 
timothy.schnell@gmail.com; Tobin M.J., mtobin2@lumc.edu) Loyola University 
of Chicago Stritch School of Medicine, Maywood, United States.
(Laghi F., flaghi@lumc.edu; Maddipati V., maddipativ15@ecu.edu; Schnell T., 
timothy.schnell@gmail.com; Langbein W.E., langbein@comcast.net; Tobin M.J., 
mtobin2@lumc.edu) Hines Veterans Affairs Hospital, Hines, United States.
CORRESPONDENCE ADDRESS
  F. Laghi, Division of Pulmonary and Critical Care Medicine, Hines VA 
Hospital (111N), 5th Ave & Roosevelt Rd, Hines, United States. Email: 
flaghi@lumc.edu
AiP/IP ENTRY DATE
  2017-03-01
FULL RECORD ENTRY DATE
  2017-03-29
SOURCE
  Respiratory Physiology and Neurobiology (2017) 240 (17-25). Date of 
Publication: 1 Jun 2017
VOLUME
  240
FIRST PAGE
  17
LAST PAGE
  25
DATE OF PUBLICATION
  1 Jun 2017
ISSN
  1878-1519 (electronic)
  1569-9048
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  Experiments were undertaken to mechanistically define expiratory-muscle 
contribution to effectiveness of cough while controlling glottic movement. 
We hypothesized that electrical abdominal-muscle stimulation in patients 
with respiratory-muscle weakness produces effective coughs only when glottic 
closure accompanies coughs. In ten spinal-cord-injury patients, 
esophago-gastric pressure and airflow were recorded during solicited-coughs, 
coughs augmented by abdominal-muscle stimulation, and passive open-glottis 
exhalations. During solicited-coughs, patients closed the glottis initially; 
five were flow-limited, five non-flow-limited. Stimulations during 
solicited-coughs or open-glottis exhalations elicited similar driving 
pressures (changes in gastric pressure; p < 0.001). Despite high driving 
pressures, stimulations induced flow-limitation only when patients 
transiently closed the glottis – not during open-glottis exhalations. That 
is, transient glottic closure enabled transmission of abdominal (driving) 
pressure to the thorax during cough, while impeding dissipation of 
intrathoracic pressure. In conclusion, transient glottic closure is 
necessary to render cough effective in patients with respiratory-muscle 
weakness, indicating that failure to close the glottis contributes to 
ineffective cough in weak tracheostomized patients and patients with bulbar 
disorders.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal wall musculature; breathing muscle; coughing; muscle weakness; neuromuscular electrical stimulation; 
EMTREE MEDICAL INDEX TERMS
  abdominal pressure; adult; aged; airflow; article; clinical article; esophagus pressure; exhalation; glottis; human; middle aged; muscle contraction; muscle excitation; priority journal; spinal cord injury; stomach pressure; thorax pressure; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170147327
MEDLINE PMID
  28213202 (http://www.ncbi.nlm.nih.gov/pubmed/28213202)
PUI
  L614520093
DOI
  10.1016/j.resp.2017.02.005
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.resp.2017.02.005
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18781519&id=doi:10.1016%2Fj.resp.2017.02.005&atitle=Determinants+of+cough+effectiveness+in+patients+with+respiratory+muscle+weakness&stitle=Respir.+Physiol.+Neurobiol.&title=Respiratory+Physiology+and+Neurobiology&volume=240&issue=&spage=17&epage=25&aulast=Laghi&aufirst=Franco&auinit=F.&aufull=Laghi+F.&coden=RPNEA&isbn=&pages=17-25&date=2017&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 186
TITLE
  Efficacy and safety of nusinersen in infants with presymptomatic spinal 
muscular atrophy (SMA): Interim results from the NURTURE study
AUTHOR NAMES
  Bertini E.; Hwu W.-L.; Reyna S.P.; Farwell W.; Gheuens S.; Sun P.; Zhong Z.J.; De Vivo D.C.
AUTHOR ADDRESSES
  (Bertini E.; Hwu W.-L.; Reyna S.P.; Farwell W.; Gheuens S.; Sun P.; Zhong 
Z.J.; De Vivo D.C.) Unit of Neuromuscular and Neurodegenerative Disorders, 
Bambino Gesu Children's Research Hospital, Rome, Italy.
CORRESPONDENCE ADDRESS
  E. Bertini, Unit of Neuromuscular and Neurodegenerative Disorders, Bambino 
Gesu Children's Research Hospital, Rome, Italy.
FULL RECORD ENTRY DATE
  2017-11-08
SOURCE
  European Journal of Paediatric Neurology (2017) 21 Supplement 1 (e14). Date 
of Publication: 1 Jun 2017
VOLUME
  21
FIRST PAGE
  e14
DATE OF PUBLICATION
  1 Jun 2017
CONFERENCE NAME
  12th European Paediatric Neurology Society Congress, EPNS 2017
CONFERENCE LOCATION
  Lyon, France
CONFERENCE DATE
  2017-06-20 to 2017-06-24
ISSN
  1532-2130
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Objective: SMA is an autosomal recessive neuromuscular disorder caused by 
mutations in the survival motor neuron 1 (SMN1) gene, which result in SMN 
protein deficiency. Nusinersen is an antisense oligonucleotide that modifies 
SMN2 pre-mRNA splicing, thereby promoting increased functional SMN protein 
levels. NURTURE (NCT02386553) is an ongoing phase 2, open-label, single-arm 
study, evaluating intrathecal nusinersen (12-mg equivalent dose) in infants 
with presymptomatic SMA. Methods: Infants enrolled in the NURTURE study must 
be presymptomatic at the time of screening, ≤<=6 weeks old at first dose, 
have genetic documentation of 5q SMA homozygous gene deletion or mutation, 
and have 2 or 3 SMN2 gene copies. The primary endpoint is the time to death 
or respiratory intervention (tracheostomy or ventilation for ≥>=6 hours/day 
for ≥>=7 days). Secondary endpoints include survival, growth parameters, 
motor milestone attainment assessed by section 2 of the Hammersmith Infant 
Neurological Examination (HINE) and WHO criteria, and change from baseline 
in Children's Hospital of Philadelphia Infant Test of Neuromuscular 
Disorders (CHOP INTEND) motor function scale. Sibling data was also 
collected. Study enrollment started in May 2015. Results: As of 8 June 2016, 
at the time of the first interim analysis, 22 infants had been screened; 17 
were enrolled and dosed. All infants remained enrolled for up to ∼13 months, 
and none met the primary endpoint of respiratory intervention or death. 
Improvements in mean HINE motor milestones scores versus baseline were 
observed. The majority of infants gained weight over time, consistent with 
normal development. Additional analyses on data collected as of November 1, 
2016 are ongoing. Data from this most recent interim analysis will be 
reported, including results for patient subgroups based on demographic and 
clinical characteristics. Conclusion: Interim analysis results demonstrate 
the efficacy and safety of nusinersen in presymptomatic infants with SMA.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE DRUG INDEX TERMS
  endogenous compound; survival motor neuron protein 2; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  child; clinical trial; death; development; documentation; gene deletion; homozygosity; human; infant; mental capacity; motor performance; neurologic examination; Pennsylvania; pharmacokinetics; sibling; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619069061
DOI
  10.1016/j.ejpn.2017.04.1218
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ejpn.2017.04.1218
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15322130&id=doi:10.1016%2Fj.ejpn.2017.04.1218&atitle=Efficacy+and+safety+of+nusinersen+in+infants+with+presymptomatic+spinal+muscular+atrophy+%28SMA%29%3A+Interim+results+from+the+NURTURE+study&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=21&issue=&spage=e14&epage=&aulast=Bertini&aufirst=E.&auinit=E.&aufull=Bertini+E.&coden=&isbn=&pages=e14-&date=2017&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 187
TITLE
  Pediatric long-term non-invasive ventilation definition and situation PLTNIV
AUTHOR NAMES
  Pavone M.; Cutrera R.
AUTHOR ADDRESSES
  (Pavone M.; Cutrera R., renato.cutrera@opbg.net) Pediatric Pulmonology and 
Respiratory Intermediate Care Unit, Academic Department of Pediatrics 
(DPUO), Pediatric Hospital Bambino, Italy.
CORRESPONDENCE ADDRESS
  R. Cutrera, Pediatric Pulmonology and Respiratory Intermediate Care Unit, 
Academic Department of Pediatrics (DPUO), Pediatric Hospital Bambino, Italy. 
Email: renato.cutrera@opbg.net
FULL RECORD ENTRY DATE
  2017-07-06
SOURCE
  Pediatric Pulmonology (2017) 52 Supplement 46 (S4-S6). Date of Publication: 
1 Jun 2017
VOLUME
  52
FIRST PAGE
  S4
LAST PAGE
  S6
DATE OF PUBLICATION
  1 Jun 2017
CONFERENCE NAME
  16th Congress of the International Pediatric Pulmonology, CIPP 2017
CONFERENCE LOCATION
  Lisbon, Portugal
CONFERENCE DATE
  2017-06-22 to 2017-06-25
ISSN
  1099-0496
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Definition Respiratory support can be distinguished as “invasive” and 
“noninvasive”. The distinction depends on the interface used for 
patientventilator connection. For non-invasive ventilation (NIV), gases are 
conducted into the airways via an external interface. For invasive 
ventilation (IMV), gases are conducted into the airways through an 
endotracheal tube or tracheostomy [1,2]. Indications for and Goals of NIV 
Non-invasive ventilation in children is indicated essentially for: 1) 
Diseases due to increased respiratory load (intrinsic cardiopulmonary 
disorders, abnormalities of the upper airways, chest wall deformities); 2) 
Disorders characterized by weakness of the respiratory muscles 
(neuromuscular diseases, spinal cord injuries); 3) Abnormal neurological 
control of ventilation(congenitalor acquiredalveolarhypoventilationsyndrome) 
[1,2]. Non-invasive ventilation can alleviate chronic respiratory failure 
through the correction of hypoventilation, the improvement of respiratory 
muscle function and reducing the workload of the respiratory system [1,2]. 
Goals of NIV are the relief from symptoms, reduction of the work of 
breathing, improvement and stabilization of gas exchanges, 
patient-ventilator synchrony, improvement of duration and quality of sleep, 
improvement of the quality of life and functional status, and prolongation 
of survival [3]. Patients and Interface Selection Long-term NIV is 
applicable to cooperative and stable patients with a certain degree of 
respiratory autonomy [1,2]. Usually, NIV is applied at night and/or during 
daytime naps [1-3]. The choice of interface depends on the characteristics 
of the patient (age, facial characteristics, degree of cooperation, and 
severity of respiratory impairment). In children, interface acceptance is 
the first step for a successful NIV program [1,2]. Nasal masks are the most 
often used interfaces, although there are promising experiences with the use 
of oro-nasal and full-face masks, nasal pillows and mouthpieces [1,2]. 
Ventilation Mode Pressure-targeted ventilation is the modality most often 
used for noninvasive ventilation [1-3]. Continuous positive airway pressure 
(CPAP) support is based on the delivery to the airways of a constant 
pressure for the whole respiratory cycle. With CPAP, the work of breathing 
is entirely up to the patient [1-3]. CPAP acts by elevating the intraluminal 
pressure of the upper airway at levels higher than those of the critical 
transmural pressure that determines the collapse of the upper airway. This 
pressure keeps the airways open, promotes relaxing of the upper airway 
dilator muscles, and reduces inspiratory muscle activity of the upper 
airways and diaphragm [1-3]. CPAP prevents alveolar collapse favoring 
alveolar recruitments and the increase in functional residual capacity. 
Through this mechanism, CPAP improves oxygenation and downloading the 
inspiratory muscles reduces the work of breathing. Bi-level positive airway 
pressure (Bi-levelPAP) provides respiratory support at two different levels. 
Using bi-level PAP is possible, therefore, to separately adjust a lower 
expiratory positive airway pressure (EPAP, CPAP) and a higher inspiratory 
positive airway pressure (IPAP, PIP). The inspiratory pressure enhances the 
patient's spontaneous inspiratory act [1-3]. The expiratory pressure allows 
eliminatingmore easily exhaled air and CO(2).TheEPAP plays the same role 
discussed above forCPAP[1-3]. The tidal volumewill be generated as the 
result of the delta between the inspiratory and expiratory pressures [1-3]. 
In Pressure Support Ventilation (PSV) mode, the ventilator ensures a maximum 
value of inspiratory pressure in the airways equal to that set by the 
operator. This pressure support allows the patient to achieve more effective 
breaths. The patient determines respiratory rate, inspiratory flow and 
inspiratory time by determining the onset of inspiration, muscle strength 
applied during the inspiration and the passage to expiration [1]. The use of 
the PSV mode allows preserving the patient's spontaneous breathing while 
ensuring the reduction of excessive work of breathing undergone by the 
patient. This mode is preferable in patients capable of spontaneous 
breathing and able to activate the ventilator cycles. In Pressure Control 
Ventilation (PCV) mode, the operator sets the maximum level of pressure that 
is delivered by the ventilator during the inspiratory act, the respiratory 
rate and the inspiratory:expiratory ratio (I:E), in the absence of 
respiratory effort. Breaths delivered by the ventilator are determined by a 
pressure, duration of inspiration and expiration default. This mode is 
preferable in severely ill patients with significant impairment of the 
muscle pump efficiency or ventilatory drive [1]. Training Program and 
Discharge Plan for Long-Term Use If NIV can be established gradually, an 
accurate clinical training session aimed at the introduction of the patient 
and family to its practice must be planned [1,2]. Training should start by 
using very low pressures and when the patient tolerates pressures throughout 
the night, the pressures can be gradually increased [1,2]. The choice of 
pressures is the process by which the clinician searches for a compromise 
between defect correction (through the increase in pressures), and the 
limitation of the side effects (with the use of a pressure as low as 
possible, although still effective) [1,2]. Pressure requests depend on the 
individual patient's current clinical condition and must be obtained from 
the evaluation of its monitoring [1-3]. Before discharge, the patient's 
respiratory status should be stable on the same ventilator, circuit and 
interfaces that the child will use at home. A personalized follow-up plan 
must always be provided [1,2]. The optimal frequency for follow-up 
evaluations has not yet been readily determined. These evaluations should 
generally be scheduled more frequently in infants and younger children 
[1,2]. On such occasions, the history and a complete clinical and 
instrumental assessment (ventilator, circuits, humidification, interfaces) 
must be performed [1,2]. Compliance should be systematically evaluated 
through the internal memory of the instrument to verify the actual time of 
ventilator use. This check also allows assessing air leakages, pressures 
delivered and nocturnal SpO(2) values [1,2]. Polysomnographic evaluations 
are recommended before initiating NIV and discharging with the ventilator, 
and during each in-hospital follow-up admission [1-3]. Pulmonary function 
tests, blood gas analysis, chest x-ray and lateral projection of the skull, 
echocardiography should be periodically repeated [1,2]. Situation An 
increasing number of children with chronic hypercapnic respiratory failure 
are currently treated with NIV [1,2]. Non-invasive ventilation allows 
preserving functions such as swallowing, feeding, speaking, coughing, 
heating/humidification of the inspired air [1]. The introduction of NIV has 
reduced the number of emergency room visits per year, tracheostomies, 
intubations and the length of stay in the pediatric intensive care units. 
Non-invasive ventilation has allowed early weaning from IMV and extubations. 
Non-invasive ventilation has also enabled preventing vocal cord or trachea 
damages, and reduce the risk of lower respiratory tract infections [1]. 
Convincing data have been reported from national surveys on long-term 
experiences with NIV performed especially in Western countries [4-7]. In the 
last years, new data have come out from developing and Eastern countries 
[8-10]. Neuromuscular disease such as Duchenne Muscular Dystrophy (DMD) and 
Spinal Muscular Atrophy (SMA), and diseases of the central nervous system 
such as the congenital central alveolar hypoventilation syndrome represent 
two main indications for NIV [4-7]. Among respiratory diseases, airway 
malacia and obstructive sleep apnea have been the most frequently treated 
with CPAP/NIV [4-7]. Children with severe physical and cognitive 
disabilities are also increasingly offered long-term ventilation to prolong 
life [4,6]. The survival is longer in patients treated with NIV than in 
those undergoing IMV [4-7]. Usually, the median age at the beginning of IVM 
ventilation is significantly lower than in those treated with NIV [4]. 
Non-invasive ventilation has been successfully started even in children 
under 1 year of age [6]. Data are available on the possible weaning from 
long-term NIV, as well as on deaths during NIV (for example in children in 
whom a palliative approach was taken) [4-10]. Children with neuromuscular 
and neurological disease are least likely to wean off from NIV. Children 
most likely to discontinue long-term NIV are those with chronic lung disease 
of prematurity, airway malacia, and upper-airways abnormalities [4-10]. 
Non-invasive ventilation failures and consequently tracheostomy and IVM have 
been reported for example in children with Cerebral Palsy [4-10].A 
significant number of patients with NIV have transitioned to adult care [7]. 
Compliance with NIV is a major issue. Data downloaded from built-in software 
showed a wide range on mean nightly use [2]. Parental assessment of PAP use 
may overestimate actual home ventilator use. In this latter study, patients 
with greater improvement in apnea-hypopnea index were more likely to be 
adherent. Clinical parameters and nighttime and daytime symptoms improved 
after PAP therapy regardless of age or adherence. Treatment adherence was 
not correlated with age, type of underlying disease, interfaces used, 
nocturnal gas exchanges, and duration of PAP treatment. Children who 
attempted to use CPAP at least 6 nights a week were treated with CPAP for a 
longer time on the nights of use. Usage in the first week of treatment 
predicted longer term use over 2 to 3 months. A predictor of PAP use was 
maternal education. Adherence was demonstrated lower in African American 
children.
EMTREE DRUG INDEX TERMS
  carbon dioxide; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  noninvasive ventilation; 
EMTREE MEDICAL INDEX TERMS
  adult; African American; apnea hypopnea index; apnea monitoring; blood gas analysis; breathing muscle; breathing pattern; breathing rate; cerebral palsy; child; chronic respiratory failure; cognitive defect; collapse; congenital central hypoventilation syndrome; coughing; daytime somnolence; death; diaphragm; Duchenne muscular dystrophy; echocardiography; education; emergency ward; endotracheal tube; expired air; extubation; face mask; family study; feeding; female; follow up; functional residual capacity; gas exchange; heating; human; humidifier; hypobarism; infant; intestine pressure; intubation; length of stay; lower respiratory tract infection; lung dysplasia; lung function test; memory; muscle function; muscle strength; neuromuscular disease; night; pediatric intensive care unit; physical disability; pressure support ventilation; quality of life; respiration load; side effect; skull; sleep disordered breathing; sleep quality; software; speech; spinal cord injury; spinal muscular atrophy; survival; swallowing; thorax deformity; thorax radiography; tissue oxygenation; tracheobronchomalacia; tracheostomy; upper respiratory tract; ventilator; vocal cord; weakness; weaning; work of breathing; workload; 
CAS REGISTRY NUMBERS
  carbon dioxide (124-38-9, 58561-67-4)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617069585
DOI
  10.1002/ppul.23726
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.23726
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10990496&id=doi:10.1002%2Fppul.23726&atitle=Pediatric+long-term+non-invasive+ventilation+definition+and+situation+PLTNIV&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=52&issue=&spage=S4&epage=S6&aulast=Pavone&aufirst=Martino&auinit=M.&aufull=Pavone+M.&coden=&isbn=&pages=S4-S6&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 188
TITLE
  Assessment of Sleep in Patients Receiving Invasive Mechanical Ventilation in 
a Specialized Weaning Unit
AUTHOR NAMES
  Huttmann S.E.; Wilms K.; Hamm C.; Magnet F.S.; Windisch W.; Storre J.H.
AUTHOR ADDRESSES
  (Huttmann S.E.; Wilms K.; Hamm C.; Magnet F.S.; Windisch W.; Storre J.H., 
storrej@kliniken-koeln.de) Department of Pneumology, Cologne-Merheim 
Hospital, Kliniken der Stadt Koeln gGmbH, Witten/Herdecke University 
Hospital, Ostmerheimer Strasse 200, Cologne, Germany.
(Storre J.H., storrej@kliniken-koeln.de) Department of Pneumology, 
University Medical Hospital, Freiburg, Germany.
CORRESPONDENCE ADDRESS
  J.H. Storre, Department of Pneumology, Cologne-Merheim Hospital, Kliniken 
der Stadt Koeln gGmbH, Witten/Herdecke University Hospital, Ostmerheimer 
Strasse 200, Cologne, Germany. Email: storrej@kliniken-koeln.de
AiP/IP ENTRY DATE
  2017-06-19
FULL RECORD ENTRY DATE
  2017-06-26
SOURCE
  Lung (2017) 195:3 (361-369). Date of Publication: 1 Jun 2017
VOLUME
  195
ISSUE
  3
FIRST PAGE
  361
LAST PAGE
  369
DATE OF PUBLICATION
  1 Jun 2017
ISSN
  1432-1750 (electronic)
  0341-2040
BOOK PUBLISHER
  Springer New York LLC, barbara.b.bertram@gsk.com
ABSTRACT
  Introduction: A restful sleep is essential for regenerative processes and 
remains crucial for patients recovering from stressful periods in the 
intensive care unit. The current study aimed to assess sleep quality in 
critically ill patients receiving invasive mechanical ventilation within a 
specialized weaning unit in hospital. Methods: Tracheotomized subjects 
undergoing prolonged weaning from mechanical ventilation were included in 
the study. Polysomnography and gas exchange monitoring was performed during 
nocturnal ventilation. Subjective evaluation of sleep quality and 
health-related quality of life were also assessed. Results: Nineteen 
subjects completed the study protocol. Sleep architecture was highly 
heterogeneous across individual subjects. Mean total sleep time (TST) was 
273 ± 114 min, sleep efficacy 70 ± 23%, slow-wave sleep 25.7 ± 18.4%/TST, 
rapid eye movement sleep 9.6 ± 7.5%/TST, and arousal index 18.7 ± 12.4/h. No 
significant difference in sleep quality was found between subjects with 
successful (N = 7) or unsuccessful (N = 12) weaning. Bicarbonate levels were 
negatively correlated both with sleep efficacy and sleep quality, that 
latter of which was subjectively assessed by the subjects using a visual 
analogue scale. Conclusion: Subjects who were undergoing prolonged weaning 
from mechanical ventilation and admitted to a specialized weaning unit, 
showed reduced sleep quality with preservation of high amounts of slow-wave 
sleep.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; sleep disordered breathing (disease management); sleep quality; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; aged; article; chronic obstructive lung disease; clinical article; critical illness; critically ill patient; female; follow up; gas exchange; human; kidney failure; kyphoscoliosis; latent period; lung congestion; male; neuromuscular disease; polysomnography; pressure transducer; priority journal; quality of life; REM sleep; sleep stage; sleep time; slow wave sleep; spinal cord injury; tracheostomy tube; tracheotomy; visual analog scale; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
CLINICAL TRIAL NUMBERS
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170427359
MEDLINE PMID
  28258358 (http://www.ncbi.nlm.nih.gov/pubmed/28258358)
PUI
  L616689954
DOI
  10.1007/s00408-017-9988-2
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00408-017-9988-2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14321750&id=doi:10.1007%2Fs00408-017-9988-2&atitle=Assessment+of+Sleep+in+Patients+Receiving+Invasive+Mechanical+Ventilation+in+a+Specialized+Weaning+Unit&stitle=Lung&title=Lung&volume=195&issue=3&spage=361&epage=369&aulast=Huttmann&aufirst=Sophie+Emilia&auinit=S.E.&aufull=Huttmann+S.E.&coden=LUNGD&isbn=&pages=361-369&date=2017&auinit1=S&auinitm=E
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 189
TITLE
  Neurological form of hemophagocytic lymphohistiocytis presenting as ADEM
AUTHOR NAMES
  Benallegue N.; Miot C.; Beloncle F.; Pellier I.; Gueden S.; Van Bogaert P.
AUTHOR ADDRESSES
  (Benallegue N.; Miot C.; Beloncle F.; Pellier I.; Gueden S.; Van Bogaert P.) 
Department of Pediatrics, Pediatric Neurology, University of Medicine of 
Angers, Angers, France.
CORRESPONDENCE ADDRESS
  N. Benallegue, Department of Pediatrics, Pediatric Neurology, University of 
Medicine of Angers, Angers, France.
FULL RECORD ENTRY DATE
  2017-11-08
SOURCE
  European Journal of Paediatric Neurology (2017) 21 Supplement 1 (e119). Date 
of Publication: 1 Jun 2017
VOLUME
  21
FIRST PAGE
  e119
DATE OF PUBLICATION
  1 Jun 2017
CONFERENCE NAME
  12th European Paediatric Neurology Society Congress, EPNS 2017
CONFERENCE LOCATION
  Lyon, France
CONFERENCE DATE
  2017-06-20 to 2017-06-24
ISSN
  1532-2130
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Objective: Hemophagocytic Lymphohistiocytis (HLH), previously called 
macrophage activation syndrome, is a rare and very aggressive disease 
related to uncontrolled massive immune activation. The typical presentation 
is a multiorgan failure with frequent central central nervous system (CNS) 
involvement. Some cases are described with only CNS involvement without 
systemic disease presentation. Aggressive immunosuppressive treatment is 
required considering high rate of mortality and morbidity. We report here a 
pure neurological form of HLH presenting as acute disseminated 
encephalomyelitis (ADEM) to stress on the difficulties diagnosing HLH, which 
may delay early appropriate treatment. Results: This 14 year-old girl 
presented with acute tetraparesis and perineal hypoesthesia, drowsiness, and 
meningism following a Ebstein-Barr Virus primary infection. Rapid 
respiratory failure required mechanical ventilation, then tracheotomy. MRI 
showed T2- weighted lesions of cerebrum with matter, basal ganglia, 
brainstem and spinal cord. CSF analysis showed 174 cells permm(3), mostly 
lymphocytes (97%), and 0.56 g/L of proteins. ADEM was first suspected but 
her clinical condition did not improve after corticotherapy, and plasma 
exchanges. In view of unfavorable evolution, high cell count in the CSF and 
some atypical MRI features for ADEM, especially asymmetric lesion in large 
area, HLH was considered. Counts of activated T lymphocytes in the CSF (CD4+ 
15% ; CD8+ 50% (N<15%))and blood were markedly elevated. The patient was 
treated by cyclosporine combined with intrathecal methotrexate injections, 
intravenous rituximab and alemtuzumab. Tetraparesis improved seven days 
after the last administration of alemtuzumab, autonomous walking was 
possible three months after initial presentation, cognitive impairment 
improved. The patient was free of relapse fifteen months after initial 
symptoms. Conclusion: Isolated CNS HLH should be considered when facing with 
ADEM not responding to usual treatment. Some particular MRI features might 
be helpful for early diagnosis. This is crucial considering that early 
effective immunosuppressive therapy is essential to prevent poor outcomes.
EMTREE DRUG INDEX TERMS
  alemtuzumab; CD4 antigen; cyclosporine; endogenous compound; methotrexate; rituximab; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute disseminated encephalomyelitis; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adverse drug reaction; artificial ventilation; basal ganglion; brain injury; brain stem; case report; cell count; clinical trial; cognitive defect; corticosteroid therapy; diagnosis; drowsiness; drug combination; drug therapy; early diagnosis; female; girl; human; human cell; hypesthesia; immunosuppressive treatment; injection; meningism; morbidity; mortality; nonhuman; nuclear magnetic resonance imaging; plasmapheresis; primary infection; quadriplegia; relapse; respiratory failure; side effect; spinal cord; stress; T lymphocyte; tracheostomy; virus; walking; 
CAS REGISTRY NUMBERS
  alemtuzumab (216503-57-0)
  cyclosporin (79217-60-0)
  methotrexate (15475-56-6, 59-05-2, 7413-34-5)
  rituximab (174722-31-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619068603
DOI
  10.1016/j.ejpn.2017.04.973
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ejpn.2017.04.973
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15322130&id=doi:10.1016%2Fj.ejpn.2017.04.973&atitle=Neurological+form+of+hemophagocytic+lymphohistiocytis+presenting+as+ADEM&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=21&issue=&spage=e119&epage=&aulast=Benallegue&aufirst=&auinit=N.&aufull=Benallegue+N.&coden=&isbn=&pages=e119-&date=2017&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 190
TITLE
  Giant Cell Tumor of Cervical Spine Presenting as Acute Asphyxia
AUTHOR NAMES
  Kumar R.; Meis J.M.; Amini B.; McEnery K.W.; Madewell J.E.; Rhines L.D.; Benjamin R.S.
AUTHOR ADDRESSES
  (Kumar R.; Amini B., bamini@mdanderson.org; McEnery K.W.; Madewell J.E.) 
Department of Diagnostic Imaging, University of Texas M.D. Anderson Cancer 
Center, Unit 1475, 1400 Pressler, Houston, United States.
(Meis J.M.) Department of Pathology, University of Texas M.D. Anderson 
Cancer Center, Houston, United States.
(Rhines L.D.) Department of Neurosurgery, University of Texas M.D. Anderson 
Cancer Center, Houston, United States.
(Benjamin R.S.) Department of Sarcoma Medical Oncology, University of Texas 
M.D. Anderson Cancer Center, Houston, United States.
CORRESPONDENCE ADDRESS
  B. Amini, Department of Diagnostic Imaging, University of Texas M.D. 
Anderson Cancer Center, Unit 1475, 1400 Pressler, Houston, United States. 
Email: bamini@mdanderson.org
AiP/IP ENTRY DATE
  2016-11-07
FULL RECORD ENTRY DATE
  2017-06-01
SOURCE
  Spine (2017) 42:10 (E629-E632). Date of Publication: 15 May 2017
VOLUME
  42
ISSUE
  10
FIRST PAGE
  E629
LAST PAGE
  E632
DATE OF PUBLICATION
  15 May 2017
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study Design. Case report and literature review. Objective. To describe 
treatment of a unique case of acute airway obstruction by a large C7 giant 
cell tumor (GCT) with preoperative denosumab followed by surgical resection, 
and review the literature on this rare entity. Summary of Background Data. 
Standard treatment for GCTs includes surgical resection or curettage and 
packing. Large lesions in the spine may require preoperative therapy with 
denosumab, a human monoclonal antibody to RANKL, to facilitate surgery. It 
is highly unusual for GCT arising in cervical spine to present with acute 
asphyxia (requiring tracheostomy). Methods. We report a patient with large 
C7 GCT that caused tracheal compression with almost complete airway 
obstruction requiring emergency intubation. Results. The tumor responded to 
subcutaneously administered denosumab with marked decrease in size and 
relief of symptoms. Increased tumor mineralization in response to therapy 
facilitated subsequent successful surgical tumor resection. The patient 
remains symptom-free 2 years after surgery without tumor recurrence. 
Conclusion. Denosumab can shrink the size of large GCTs, providing symptom 
relief before surgery and facilitate tumor resection.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  denosumab (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  asphyxia; cancer chemotherapy; cancer surgery; giant cell tumor (drug therapy, drug therapy, surgery); giant cell tumor of cervical spine (drug therapy, drug therapy, surgery); preoperative care; spine tumor (drug therapy, drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; airway obstruction; article; cancer patient; case report; computer assisted tomography; curettage; dyspnea; female; follow up; human; laminectomy; nuclear magnetic resonance imaging; outcome assessment; priority journal; radiology; respiratory tract intubation; seventh cervical vertebra; trachea compression; tumor recurrence; tumor volume; wheezing; young adult; 
CAS REGISTRY NUMBERS
  denosumab (615258-40-7)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160786794
MEDLINE PMID
  27792106 (http://www.ncbi.nlm.nih.gov/pubmed/27792106)
PUI
  L612987512
DOI
  10.1097/BRS.0000000000001951
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000001951
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000001951&atitle=Giant+Cell+Tumor+of+Cervical+Spine+Presenting+as+Acute+Asphyxia&stitle=Spine&title=Spine&volume=42&issue=10&spage=E629&epage=E632&aulast=Kumar&aufirst=Rajendra&auinit=R.&aufull=Kumar+R.&coden=SPIND&isbn=&pages=E629-E632&date=2017&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 191
TITLE
  Physician driven variation in the care of children with spinal muscular 
atrophy type 1
AUTHOR NAMES
  Oskoui M.; Ng P.; Liben S.; Zielinski D.
AUTHOR ADDRESSES
  (Oskoui M., Maryam.Oskoui@mcgill.ca; Liben S.; Zielinski D.) Department of 
Pediatrics, McGill University, Montréal, Canada.
(Oskoui M., Maryam.Oskoui@mcgill.ca) Department of Neurology and 
Neurosurgery, McGill University, Montréal, Canada.
(Ng P.) McGill University Health Center Research Institute, Montréal, 
Canada.
CORRESPONDENCE ADDRESS
  M. Oskoui, Department of Pediatrics, McGill University, Montréal, Canada. 
Email: Maryam.Oskoui@mcgill.ca
AiP/IP ENTRY DATE
  2016-10-14
FULL RECORD ENTRY DATE
  2017-05-08
SOURCE
  Pediatric Pulmonology (2017) 52:5 (662-668). Date of Publication: 1 May 2017
VOLUME
  52
ISSUE
  5
FIRST PAGE
  662
LAST PAGE
  668
DATE OF PUBLICATION
  1 May 2017
ISSN
  1099-0496 (electronic)
  8755-6863
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Background: Increasing numbers of families are requesting active supportive 
management for their child with spinal muscular atrophy type 1 (SMA1), 
leading to longer survival and greater prevalence of affected children. 
Strong opinions exist among physicians for and against the provision of care 
measures prolonging life. Objective: To describe current practice in the 
care of SMA1 in Canada, and explore the factors underlying inter-physician 
variability. Methods: A cross-sectional survey of Canadian hospital-based 
pediatric neurologists and pediatric respirologists was performed in 2015. 
Odds ratios and 95% confidence intervals were calculated to compare 
proportions between groups. Results: There was a 54% completion rate (99 
physicians). Over half of participants believed that a disease modifying 
therapy was likely within 10 years. Quebec respirologists were 50 times less 
likely to offer long-term non-invasive ventilation (NIV) than respirologists 
in other provinces (OR 50.6, 95% CI 2.4–1075.3), and 20 times less likely to 
discuss tracheostomy with families (OR 20.4, 95% CI 2.0–211.8). High raters 
of perceived happiness of affected children were more likely to find NIV an 
acceptable measure for acute (OR 6.7, 95% CI 1.7–26.0) and chronic (OR 13.7, 
95% CI 4.0–46.4) respiratory failure and prophylactic use (OR 5.8, 95% CI 
2.2–15.6). Conclusion: Physician knowledge, opinions, subjective perception 
of child happiness, and regional factors, all influence physicians’ 
practices and the shared decision-making process. Parents may not be 
informed or offered all the services available to their child. Knowledge 
translation initiatives are needed to enhance SMA1 care. Pediatr Pulmonol. 
2017;52:662–668. © 2016 Wiley Periodicals, Inc.
EMTREE DRUG INDEX TERMS
  antiinflammatory agent (drug therapy); disease modifying treatment (drug therapy); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child care; clinical practice; health care access; inter physician variability; medical education; spinal muscular atrophy (drug therapy, diagnosis, drug therapy); Werdnig Hoffmann disease (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  aeration; article; breathing exercise; Canada; child; chronic respiratory failure (prevention, surgery, therapy); controlled study; cross-sectional study; endotracheal intubation; female; gas exchange; gas mask; happiness; hospitalization; human; hypoventilation; life expectancy; lung clearance; lung volume; major clinical study; male; mechanical insufflation exsufflation device; medical decision making; medical specialist; neurologist; noninvasive ventilation; palliative therapy; pediatrics; perception; physician; positive end expiratory pressure; prophylaxis; quality of life; Quebec; respirologist; social support; suction; tracheostomy; treatment duration; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Occupational Health and Industrial Medicine (35)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160727439
MEDLINE PMID
  27685758 (http://www.ncbi.nlm.nih.gov/pubmed/27685758)
PUI
  L612636106
DOI
  10.1002/ppul.23616
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.23616
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10990496&id=doi:10.1002%2Fppul.23616&atitle=Physician+driven+variation+in+the+care+of+children+with+spinal+muscular+atrophy+type+1&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=52&issue=5&spage=662&epage=668&aulast=Oskoui&aufirst=Maryam&auinit=M.&aufull=Oskoui+M.&coden=PEPUE&isbn=&pages=662-668&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 192
TITLE
  Lateral mass lesion of C1
AUTHOR NAMES
  Cabrita F.; Carvalho M.; Sincari M.
AUTHOR ADDRESSES
  (Cabrita F.; Carvalho M.; Sincari M.) Centro Hospitalar Tondela-Viseu, 
Portugal.
CORRESPONDENCE ADDRESS
  F. Cabrita, Centro Hospitalar Tondela-Viseu, Portugal.
FULL RECORD ENTRY DATE
  2017-08-24
SOURCE
  Sinapse (2017) 17:1 (71). Date of Publication: 1 May 2017
VOLUME
  17
ISSUE
  1
FIRST PAGE
  71
DATE OF PUBLICATION
  1 May 2017
CONFERENCE NAME
  Neuro 2017
CONFERENCE LOCATION
  Funchal, Portugal
CONFERENCE DATE
  2017-06-01 to 2017-06-03
ISSN
  1645-281X
BOOK PUBLISHER
  Sociedade Portuguesa de Neurologia
ABSTRACT
  The surgical removal of C1 lateral mass lesions is challenging due to the 
close relationship with vertebral artery and plexus and upper spinal cord. 
We report a case of a 49-year-old female presenting with severe 
occipitocervical pain, aggravating during the night period and with neck 
mobilization. The patient with a previous diagnosis of breast cancer (9 
years before) submitted to left mastectomy. MRI and CT Scans showed an 
osteolytic lesion on the left lateral mass of C1 with signs of C0-C1-C2 
instability. Vascular studies showed left vertebral artery compression on 
the transverse foramen without occlusion. Osteoarticular scintigraphy 
reveled no other skeletal lesions. The lesion was removed and and 
substituted by with a Harms cage and an occipito-cervical fusion was 
performed by single midline dorsal cervical approach for the upper spine. 
The patient recovered immediately after surgery with no neurological 
deficits recorded. In the early post-operative period the patient developed 
acute respiratory distress due to traqueal oedema with need for 
re-intubation and ventilatory support for three days and kept tracheostomy 
for one month with full recovery, posteriorly. Posterior midline approach is 
suitable for these lesions specially in cases when posterior fixation and 
fusion are warranted.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer size; metastasis; spine; 
EMTREE MEDICAL INDEX TERMS
  adult; assisted ventilation; bone atrophy; bone lesion; breast cancer; case report; compression; diagnosis; dorsal region; edema; female; human; intubation; mastectomy; middle aged; neck; neurologic disease; night; nuclear magnetic resonance imaging; occlusion; pain; postoperative period; respiratory distress; scintigraphy; surgery; tracheostomy; vertebral artery; x-ray computed tomography; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617902199
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1645281X&id=doi:&atitle=Lateral+mass+lesion+of+C1&stitle=Sinapse&title=Sinapse&volume=17&issue=1&spage=71&epage=&aulast=Cabrita&aufirst=Francisco&auinit=F.&aufull=Cabrita+F.&coden=&isbn=&pages=71-&date=2017&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 193
TITLE
  Airway adverse events following posterior occipito-cervical spinal fusion
AUTHOR NAMES
  Sheshadri V.; Moga R.; Manninen P.; Goldstein C.L.; Rampersaud Y.R.; Massicotte E.M.; Fehlings M.G.; Venkatraghavan L.
AUTHOR ADDRESSES
  (Sheshadri V., drveena_4u@yahoo.co.in; Moga R., Rebecca.Moga@uhn.ca; 
Manninen P., Pirjo.Manninen@uhn.ca; Venkatraghavan L., 
Lashmi.Venkatraghavan@uhn.ca) Department of Anesthesia, Toronto Western 
Hospital, University of Toronto, Canada.
(Goldstein C.L., goldsteincl@health.missouri.edu) Department of Orthopedic 
Surgery, Columbia, United States.
(Rampersaud Y.R., Raja.Rampersaud@uhn.ca) Department of Surgery, Divisions 
of Orthopedic and Neurosurgery, Toronto Western Hospital, University of 
Toronto, Canada.
(Massicotte E.M., Eric.Massicotte@uhn.on.ca; Fehlings M.G., 
Michael.Fehlings@uhn.ca) Department of Surgery, Division of Neurosurgery, 
Toronto Western Hospital, University of Toronto, Canada.
(Massicotte E.M., Eric.Massicotte@uhn.on.ca; Fehlings M.G., 
Michael.Fehlings@uhn.ca) Spine Program, McEwen Centre for Regenerative 
Medicine, Toronto Western Hospital, University Health Network, Canada.
CORRESPONDENCE ADDRESS
  L. Venkatraghavan, Department of Anesthesia, Toronto Western Hospital 399, 
Bathurst Street, MCL 2-405, Toronto, Canada. Email: 
Lashmi.Venkatraghavan@uhn.ca
AiP/IP ENTRY DATE
  2017-01-20
FULL RECORD ENTRY DATE
  2017-04-18
SOURCE
  Journal of Clinical Neuroscience (2017) 39 (124-129). Date of Publication: 1 
May 2017
VOLUME
  39
FIRST PAGE
  124
LAST PAGE
  129
DATE OF PUBLICATION
  1 May 2017
ISSN
  1532-2653 (electronic)
  0967-5868
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  Management of the airway may be challenging in patients undergoing 
occipito-cervical spine fusions (OCF). Changes in the occipito-cervical 
angle (dOC2A) of fusion after surgery may result in acute airway 
obstruction, dyspnea and/or dysphagia. Objectives of the study were to 
review the airway management of patients during posterior OCF, determine the 
incidence, nature and risk factors for postoperative airway adverse events 
(AEs), and to determine the relationship between airway AEs and the change 
in dOC2A. In this retrospective cohort of 59 patients, following extubation 
in the operating room (OR), there were no complications in 43 (73%) patients 
(Group 1). Sixteen (27%) patients (Group 2) had airway complications; 4 
requiring reintubation and 12 having delayed extubation. The number of 
vertebral levels fused (>6), presence of difficult intubation and duration 
of surgery (>5 h) were significantly associated with AEs. There was no 
significant difference in the dOC2A between the groups (−1.070 ± 5.527 
versus −4.375 ± 10.788, p = 0.127). Airway management in patients undergoing 
OCF poses a challenge for the anesthesiology and surgical teams. The 
incidence of AEs was 27%. The decision to extubate immediately after surgery 
needs to be individualized. Factors such as difficult intubation, number of 
vertebral levels fused and duration of surgery have to be considered. A 
significant correlation between dOC2A and postoperative AEs could not be 
established. Risk factors for postoperative AEs are multifactorial and 
prospective evaluation of these factors is indicated.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  posterior occipitocervical spine fusion; posterior spine fusion; respiratory tract disease (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; ankylosing spondylitis; article; cohort analysis; controlled study; extubation; female; fiberoptic bronchoscopy; human; intubation; Klippel Feil syndrome; laryngeal mask; macroglossia; major clinical study; male; middle aged; mucopolysaccharidosis; operation duration; oxygen desaturation; reintubation; repeat procedure; respiratory distress (therapy); retrospective study; rheumatoid arthritis; spine fracture; spine metastasis; stridor; tracheostomy; upper respiratory tract obstruction; young adult; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170045625
MEDLINE PMID
  28110925 (http://www.ncbi.nlm.nih.gov/pubmed/28110925)
PUI
  L614084895
DOI
  10.1016/j.jocn.2016.12.036
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jocn.2016.12.036
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15322653&id=doi:10.1016%2Fj.jocn.2016.12.036&atitle=Airway+adverse+events+following+posterior+occipito-cervical+spinal+fusion&stitle=J.+Clin.+Neurosci.&title=Journal+of+Clinical+Neuroscience&volume=39&issue=&spage=124&epage=129&aulast=Sheshadri&aufirst=Veena&auinit=V.&aufull=Sheshadri+V.&coden=JCNUE&isbn=&pages=124-129&date=2017&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 194
TITLE
  COUNTERPOINT: Is Noninvasive Ventilation Always the Most Appropriate Manner 
of Long-term Ventilation for Infants With Spinal Muscular Atrophy Type 1? No
AUTHOR NAMES
  Panitch H.B.
AUTHOR ADDRESSES
  (Panitch H.B., panitch@email.chop.edu) Perelman School of Medicine at The 
University of Pennsylvania, Division of Pulmonary Medicine, Children's 
Hospital of Philadelphia, Philadelphia, United States.
AiP/IP ENTRY DATE
  2019-01-30
FULL RECORD ENTRY DATE
  2019-02-08
SOURCE
  Chest (2017) 151:5 (965-968). Date of Publication: 1 May 2017
VOLUME
  151
ISSUE
  5
FIRST PAGE
  965
LAST PAGE
  968
DATE OF PUBLICATION
  1 May 2017
ISSN
  1931-3543 (electronic)
BOOK PUBLISHER
  NLM (Medline)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  procedures; 
EMTREE MEDICAL INDEX TERMS
  hereditary spinal muscular atrophy (therapy); human; infant; mortality; noninvasive ventilation; preschool child; survival rate; tracheostomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  27989616 (http://www.ncbi.nlm.nih.gov/pubmed/27989616)
PUI
  L626100920
DOI
  10.1016/j.chest.2016.11.039
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.chest.2016.11.039
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19313543&id=doi:10.1016%2Fj.chest.2016.11.039&atitle=COUNTERPOINT%3A+Is+Noninvasive+Ventilation+Always+the+Most+Appropriate+Manner+of+Long-term+Ventilation+for+Infants+With+Spinal+Muscular+Atrophy+Type+1%3F+No&stitle=Chest&title=Chest&volume=151&issue=5&spage=965&epage=968&aulast=Panitch&aufirst=Howard+B.&auinit=H.B.&aufull=Panitch+H.B.&coden=&isbn=&pages=965-968&date=2017&auinit1=H&auinitm=B
COPYRIGHT
  This record is sourced from MEDLINE®/PubMed®, a database of the U.S. 
National Library of Medicine

RECORD 195
TITLE
  POINT: Is Noninvasive Ventilation Always the Most Appropriate Manner of 
Long-term Ventilation for Infants With Spinal Muscular Atrophy Type 1? Yes, 
Almost Always
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@njms.rutgers.edu) Department of Physical Medicine and 
Rehabilitation, Rutgers New Jersey Medical School, Newark, United States.
AiP/IP ENTRY DATE
  2019-01-30
FULL RECORD ENTRY DATE
  2019-02-08
SOURCE
  Chest (2017) 151:5 (962-965). Date of Publication: 1 May 2017
VOLUME
  151
ISSUE
  5
FIRST PAGE
  962
LAST PAGE
  965
DATE OF PUBLICATION
  1 May 2017
ISSN
  1931-3543 (electronic)
BOOK PUBLISHER
  NLM (Medline)
EMTREE MEDICAL INDEX TERMS
  complication; extubation; hereditary spinal muscular atrophy (therapy); human; infant; mortality; noninvasive ventilation; preschool child; procedures; respiratory failure (etiology, therapy); survival rate; tracheotomy; treatment outcome; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  27989614 (http://www.ncbi.nlm.nih.gov/pubmed/27989614)
PUI
  L626100899
DOI
  10.1016/j.chest.2016.11.043
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.chest.2016.11.043
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19313543&id=doi:10.1016%2Fj.chest.2016.11.043&atitle=POINT%3A+Is+Noninvasive+Ventilation+Always+the+Most+Appropriate+Manner+of+Long-term+Ventilation+for+Infants+With+Spinal+Muscular+Atrophy+Type+1%3F+Yes%2C+Almost+Always&stitle=Chest&title=Chest&volume=151&issue=5&spage=962&epage=965&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=962-965&date=2017&auinit1=J&auinitm=R
COPYRIGHT
  This record is sourced from MEDLINE®/PubMed®, a database of the U.S. 
National Library of Medicine

RECORD 196
TITLE
  Real-time ultrasound imaging biofeedback training is diaphragmatic function 
in nontraumatic cervical spinal cord injury: a single-subject experimental 
study
AUTHOR NAMES
  Kim J.-S.; Oh D.-W.
AUTHOR ADDRESSES
  (Kim J.-S.) Department of Physical Therapy, College of Health and Welfare, 
Kyungwoon University, Gumi-si, South Korea.
(Oh D.-W., odduck@cju.ac.kr) Department of Physical Therapy, College of 
Health Science, Cheongju University, Cheongju-si, South Korea.
CORRESPONDENCE ADDRESS
  D.-W. Oh, Department of Physical Therapy, College of Health Science, 
Cheongju University, 289, Daeseong-ro, Cheongwon-gu, Cheongju-si, South 
Korea. Email: odduck@cju.ac.kr
AiP/IP ENTRY DATE
  2016-11-08
FULL RECORD ENTRY DATE
  2017-05-17
SOURCE
  European Journal of Physiotherapy (2017) 19:2 (69-75). Date of Publication: 
3 Apr 2017
VOLUME
  19
ISSUE
  2
FIRST PAGE
  69
LAST PAGE
  75
DATE OF PUBLICATION
  3 Apr 2017
ISSN
  2167-9177 (electronic)
  2167-9169
BOOK PUBLISHER
  Taylor and Francis Ltd, healthcare.enquiries@informa.com
ABSTRACT
  This study aimed to describe, and report the results from a detailed 
procedure of a diaphragmatic breathing exercise using real-time ultrasound 
imaging biofeedback (RUIB) training. The subject was a 16-year-old man with 
an incomplete cervical spinal cord injury (CSCI) caused by spinal 
intramedullary arteriovenous malformations at the level of his C4–C5 spinal 
cord. Although he could walk independently, decreased respiratory function 
was one of the major factors reducing his ability to perform daily 
activities, such as walking. Outcome measures included a 10-meter walk test 
(10MWT) results, balance ability in eyes open and closed, diaphragm movement 
distance on sniffing, and forced vital capacity. All parameters except the 
10MWT results appeared to significantly improve during the intervention 
phase. Data points during both the intervention and follow-up phases showed 
improved trends in comparison to those in the baseline phase, indicating 
that intervention might be beneficial in improving respiratory function and 
performance and that these gains can be maintained after the intervention. 
Our findings suggest that the use of RUIB during breathing exercise may be 
valuable in managing respiratory and physical function of patients with 
cervical cord injuries.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  biofeedback; cervical spinal cord injury (complication, therapy); diaphragm; real time echography; 
EMTREE MEDICAL INDEX TERMS
  adolescent; arteriovenous malformation; article; Barthel index; body equilibrium; breathing exercise; case report; cervical spinal cord; daily life activity; diaphragm movement; experimental study; follow up; forced vital capacity; human; laminectomy; lung capacity; male; muscle training; nuclear magnetic resonance imaging; outcome assessment; respiratory function; sniffing; spinal intramedullary arteriovenous malformation; stretching exercise; tracheostomy; walk test; walking; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160790066
PUI
  L612999023
DOI
  10.1080/21679169.2016.1247909
FULL TEXT LINK
  http://dx.doi.org/10.1080/21679169.2016.1247909
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21679177&id=doi:10.1080%2F21679169.2016.1247909&atitle=Real-time+ultrasound+imaging+biofeedback+training+is+diaphragmatic+function+in+nontraumatic+cervical+spinal+cord+injury%3A+a+single-subject+experimental+study&stitle=Europ.+J.+Physiother.&title=European+Journal+of+Physiotherapy&volume=19&issue=2&spage=69&epage=75&aulast=Kim&aufirst=Ji-Seon&auinit=J.-S.&aufull=Kim+J.-S.&coden=&isbn=&pages=69-75&date=2017&auinit1=J&auinitm=-S
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 197
TITLE
  Paediatric spinal cord infarction—a review of the literature and two case 
reports
AUTHOR NAMES
  Sheikh A.; Warren D.; Childs A.-M.; Russell J.; Liddington M.; Guruswamy V.; Chumas P.
AUTHOR ADDRESSES
  (Sheikh A., asim.sheikh@nhs.net; Chumas P.) Department of Neurosurgery, 
Leeds General Infirmary, Great George Street, Leeds, United Kingdom.
(Warren D.) Department of Radiology, Leeds, United Kingdom.
(Childs A.-M.) Department of Paediatrics, Leeds, United Kingdom.
(Russell J.) Department of Maxillofacial surgery, Leeds, United Kingdom.
(Liddington M.) Department of plastic surgery, Leeds, United Kingdom.
(Guruswamy V.) Department of Anaesthesia, Leeds, United Kingdom.
CORRESPONDENCE ADDRESS
  A. Sheikh, Department of Neurosurgery, Leeds General Infirmary, Great George 
Street, Leeds, United Kingdom. Email: asim.sheikh@nhs.net
AiP/IP ENTRY DATE
  2016-12-01
FULL RECORD ENTRY DATE
  2017-04-19
SOURCE
  Child's Nervous System (2017) 33:4 (671-676). Date of Publication: 1 Apr 
2017
VOLUME
  33
ISSUE
  4
FIRST PAGE
  671
LAST PAGE
  676
DATE OF PUBLICATION
  1 Apr 2017
ISSN
  1433-0350 (electronic)
  0256-7040
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Ischemic spinal cord infarction is rare in the paediatric population, and 
when it does occur, it is usually associated with traumatic injury. Other 
potential causes include congenital cardiovascular malformations, cerebellar 
herniation, thromboembolic disease and infection. Magnetic resonance imaging 
(MRI) findings can be subtle in the early evaluation of such patients. The 
outcome is variable and depends on the level and extent of the spinal cord 
infarct and subsequent rehabilitation. Here, we present two cases of 
ischemic spinal cord infarction in children.
EMTREE DRUG INDEX TERMS
  antiinfective agent (drug therapy); blood clotting factor 5 Leiden (endogenous compound); cardiolipin antibody (endogenous compound); fibrinogen (endogenous compound); glycoprotein (endogenous compound); hemoglobin (endogenous compound); immunoglobulin G (endogenous compound); lupus anticoagulant (endogenous compound); phospholipid antibody (endogenous compound); steroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood disease (rehabilitation, surgery); spinal cord infarction (rehabilitation, surgery); 
EMTREE MEDICAL INDEX TERMS
  anti-infective therapy; arm movement; artery catheterization; article; case report; cervical spinal cord; chest infection; child; erythrocyte transfusion; female; flaccid paralysis (rehabilitation); follow up; gene mutation; hemoglobin blood level; human; international normalized ratio; male; mean arterial pressure; myelitis (drug therapy); neuroimaging; neurorehabilitation; nuclear magnetic resonance imaging; pediatric physiotherapy; pediatric rehabilitation; pediatric surgery; positive end expiratory pressure; preschool child; priority journal; prothrombin time; steroid therapy; supine position; tracheostomy; walking; 
CAS REGISTRY NUMBERS
  fibrinogen (9001-32-5)
  hemoglobin (9008-02-0)
  immunoglobulin G (97794-27-9)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Rehabilitation and Physical Medicine (19)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160869026
MEDLINE PMID
  27889817 (http://www.ncbi.nlm.nih.gov/pubmed/27889817)
PUI
  L613446779
DOI
  10.1007/s00381-016-3295-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-016-3295-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14330350&id=doi:10.1007%2Fs00381-016-3295-8&atitle=Paediatric+spinal+cord+infarction%E2%80%94a+review+of+the+literature+and+two+case+reports&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=33&issue=4&spage=671&epage=676&aulast=Sheikh&aufirst=Asim&auinit=A.&aufull=Sheikh+A.&coden=CNSYE&isbn=&pages=671-676&date=2017&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 198
TITLE
  Healthcare resource use in patients with diagnosis of spinal muscular 
atrophy (SMA) in Optum™ U.S. Claims Database
AUTHOR NAMES
  Teynor M.; Hou Q.; Zhou J.; Hall E.; Wells W.; Avendano J.
AUTHOR ADDRESSES
  (Teynor M.; Hou Q.; Zhou J.; Hall E.; Wells W.; Avendano J.) Biogen, 
Cambridge, United States.
CORRESPONDENCE ADDRESS
  M. Teynor, Biogen, Cambridge, United States.
FULL RECORD ENTRY DATE
  2017-06-06
SOURCE
  Neurology (2017) 88:16 Supplement 1. Date of Publication: 1 Apr 2017
VOLUME
  88
ISSUE
  16
DATE OF PUBLICATION
  1 Apr 2017
CONFERENCE NAME
  69th American Academy of Neurology Annual Meeting, AAN 2017
CONFERENCE LOCATION
  Boston, MA, United States
CONFERENCE DATE
  2017-04-22 to 2017-04-28
ISSN
  1526-632X
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Objective: Describe HRU among patients with diagnostic codes for SMA in a US 
commercial claims database. Background: SMA is a devastating rare, autosomal 
recessive neuromuscular disease clinically characterized by severe and 
progressive muscular atrophy and weakness. HRU in SMA has been shown to be 
high; however, no published studies have assessed HRU in U.S. commercial 
claims data. Design/Methods: We conducted a retrospective analysis of 
Optum's Clinformatics™ DataMart for MultiPlan, a large US insurance claims 
database covering approximately 96.7 million lives from 49 plans across 
seven regions. Patients included in this analysis were born between January 
2004 and September 2015 with >2 diagnostic codes for SMA (ICD-9: 335.0 or 
335.1×) ≥31 days apart. Descriptive statistics were used. Results: 3,146 
patients had ≥2 diagnostic codes for SMA ≥31 days apart, of which 342 met 
inclusion criteria (51% male; average age 2.1 years). Median follow-up time 
was 19.1 months (average 36.9 months). Top diagnosis claims included lack of 
coordination (63%), acute respiratory infections (62%), respiratory 
abnormality (56%), cough (54%), and feeding difficulties/mismanagement 
(50%). Only 3.8% of patients had a claim for genetic testing. 66.4% had ≥1 
inpatient stay (average 3.5 per patient) with a mean length of stay (LOS) of 
10 days (median 4 days), and a maximum LOS of 389 days. Top inpatient claims 
included pneumonia (23%), pulmonary collapse (18%), respiratory failure 
(16%), gastrostomy status (15%), and esophageal reflux (15%). 64% had ≥1 ER 
visit. Patients averaged 225 outpatient visits. Claims for g-tubes and 
tracheostomy occurred in 25% and 7% of patients, respectively. Suction 
machines (47%), cough assist (38%), and BiPAP/CPAP (36%) were the most 
prevalent durable medical equipment claims. Conclusions: Patients with 
diagnostic codes for SMA demonstrated high HRU, consistent with the clinical 
course of SMA. Further analysis is warranted to understand the economic 
burden of HRU in SMA to inform research efforts for therapeutic 
interventions.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  data base; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  atelectasis; child; congenital malformation; coordination disorder; coughing; diagnosis; disease course; feeding difficulty; female; follow up; gastroesophageal reflux; gastrostomy; genetic screening; hospital patient; human; ICD-9; insurance; length of stay; machine; major clinical study; male; non continuous ventilator; outpatient; pneumonia; positive end expiratory pressure; preschool child; respiratory failure; respiratory tract infection; retrospective study; statistics; suction; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L616551053
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1526632X&id=doi:&atitle=Healthcare+resource+use+in+patients+with+diagnosis+of+spinal+muscular+atrophy+%28SMA%29+in+Optum%E2%84%A2+U.S.+Claims+Database&stitle=Neurology&title=Neurology&volume=88&issue=16&spage=&epage=&aulast=Teynor&aufirst=Megan&auinit=M.&aufull=Teynor+M.&coden=&isbn=&pages=-&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 199
TITLE
  Interim efficacy and safety results from the Phase 2 NURTURE study 
evaluating nusinersen in presymptomatic infants with spinal muscular atrophy
AUTHOR NAMES
  De Vivo D.C.; Hwu W.-L.; Reyna S.P.; Farwell W.; Gheuens S.; Sun P.; Zhong Z.J.; Su J.; Schneider E.; Bertini E.
AUTHOR ADDRESSES
  (De Vivo D.C.) Department of Neurology, Columbia University Medical Center, 
New York, United States.
(Hwu W.-L.) Department of Medical Genetics and Pediatrics, National Tawan 
University Hospital, Taipei, Taiwan.
(Reyna S.P.; Farwell W.; Gheuens S.; Sun P.; Zhong Z.J.) Biogen, Cambridge, 
United States.
(Su J.; Schneider E.) Ionis Pharmaceuticals Inc., Carlsbad, United States.
(Bertini E.) Unit for Neuromuscular and Neurodegenerative Disorders, 
Department of Neurosciences, Bambino Gesu Children's Research Hospital, 
Rome, Italy.
CORRESPONDENCE ADDRESS
  D.C. De Vivo, Department of Neurology, Columbia University Medical Center, 
New York, United States.
FULL RECORD ENTRY DATE
  2017-06-06
SOURCE
  Neurology (2017) 88:16 Supplement 1. Date of Publication: 1 Apr 2017
VOLUME
  88
ISSUE
  16
DATE OF PUBLICATION
  1 Apr 2017
CONFERENCE NAME
  69th American Academy of Neurology Annual Meeting, AAN 2017
CONFERENCE LOCATION
  Boston, MA, United States
CONFERENCE DATE
  2017-04-22 to 2017-04-28
ISSN
  1526-632X
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Objective: NURTURE (NCT02386553) is an ongoing phase 2, open-label, 
single-arm study, evaluating intrathecal nusinersen (12-mg equivalent dose) 
in infants with presymptomatic spinal muscular atrophy (SMA). Background: 
SMA is a neuromuscular disorder caused by a mutation in the survival motor 
neuron 1 (SMN1) gene resulting in SMN protein deficiency. Nusinersen is an 
investigational antisense oligonucleotide drug that modifies SMN2 pre-mRNA 
splicing, promoting increased functional SMN protein production. 
Design/Methods: NURTURE is enrolling presymptomatic infants with genetically 
diagnosed SMA and evaluating their development from near birth to 2.5 years. 
The primary endpoint is time to death or respiratory intervention 
(tracheostomy/any ventilation support for ≥6 hours/day continuously for ≥7 
days). Secondary endpoints include the proportion of infants developing 
clinical symptoms of SMA and achievement of motor milestones. Changes in 
compound muscle action potential (CMAP) and adverse events (AEs) also were 
assessed. Study enrollment started May 2015; interim results are reported. 
Results: As of 8 Jun 2016, 22 infants were screened; 17 were enrolled and 
dosed; 5 failed screening. Most (12/17) had 2 SMN2 copies, and most were 
aged ≤1 month at enrollment. All 17 infants remain enrolled; none have met 
the primary endpoints of respiratory intervention or death. Improvements in 
mean Hammersmith Infant Neurological Examination (HINE) motor milestones 
scores vs Baseline have been observed. Infants have generally gained weight 
over time consistent with normal development, and mean CMAP scores have 
mostly improved vs Baseline. There were no severe AEs reported, 5 infants 
experienced a serious AE. Three infants experienced AEs considered possibly 
related to study drug. No new safety concerns were identified. Conclusions: 
The NURTURE interim analysis shows that all the infants treated with 
nusinersen are alive and generally achieving new motor skills and 
appropriate age-related developmental gains. The efficacy and safety profile 
of nusinersen supports continued clinical development.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nusinersen; 
EMTREE DRUG INDEX TERMS
  endogenous compound; protein c jun; survival motor neuron protein; survival motor neuron protein 1; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  controlled study; female; male; safety; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  achievement; adverse drug reaction; assisted ventilation; clinical article; clinical trial; controlled clinical trial; death; development; diagnosis; drug therapy; gene expression; gene mutation; genetic predisposition; human; infant; motor performance; muscle action potential; neurologic examination; pharmacokinetics; phase 2 clinical trial; protein deficiency; RNA splicing; screening; side effect; symptom; tracheostomy; 
CAS REGISTRY NUMBERS
  nusinersen (1258984-36-9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L616552485
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1526632X&id=doi:&atitle=Interim+efficacy+and+safety+results+from+the+Phase+2+NURTURE+study+evaluating+nusinersen+in+presymptomatic+infants+with+spinal+muscular+atrophy&stitle=Neurology&title=Neurology&volume=88&issue=16&spage=&epage=&aulast=De+Vivo&aufirst=Darryl+C.&auinit=D.C.&aufull=De+Vivo+D.C.&coden=&isbn=&pages=-&date=2017&auinit1=D&auinitm=C
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 200
TITLE
  TBCD may be a causal gene in progressive neurodegenerative encephalopathy 
with atypical infantile spinal muscular atrophy
AUTHOR NAMES
  Ikeda T.; Nakahara A.; Nagano R.; Utoyama M.; Obara M.; Moritake H.; Uechi T.; Mitsui J.; Ishiura H.; Yoshimura J.; Doi K.; Kenmochi N.; Morishita S.; Nishino I.; Tsuji S.; Nunoi H.
AUTHOR ADDRESSES
  (Ikeda T., toshio-ikeda@med.miyazaki-u.ac.jp; Utoyama M.; Obara M.; Moritake 
H.; Nunoi H.) Division of Pediatrics, Department of Developmental and 
Urological-Reproductive Medicine Pediatrics, Faculty of Medicine, University 
of Miyazaki, Miyazaki, Japan.
(Nakahara A.) Department of Pediatrics, National Hospital Organization 
Miyazaki Hospital, Miyazaki, Japan.
(Nagano R.) Department of Pediatrics, Aisenkai Nichinan Hospital, Miyazaki, 
Japan.
(Uechi T.; Kenmochi N.) Frontier Science Research Center, University of 
Miyazaki, Miyazaki, Japan.
(Mitsui J.; Ishiura H.; Tsuji S.) Department of Neurology, University of 
Tokyo, Graduate School of Medicine, Tokyo, Japan.
(Yoshimura J.; Doi K.; Morishita S.) Department of Computational Biology and 
Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 
Chiba, Japan.
(Nishino I.) Department of Neuromuscular Research, National Institute of 
Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  T. Ikeda, Division of Pediatrics, Department of Developmental and 
Urological-Reproductive Medicine Pediatrics, Faculty of Medicine, University 
of Miyazaki, Miyazaki, Japan. Email: toshio-ikeda@med.miyazaki-u.ac.jp
AiP/IP ENTRY DATE
  2017-04-04
FULL RECORD ENTRY DATE
  2017-04-24
SOURCE
  Journal of Human Genetics (2017) 62:4 (473-480). Date of Publication: 1 Apr 
2017
VOLUME
  62
ISSUE
  4
FIRST PAGE
  473
LAST PAGE
  480
DATE OF PUBLICATION
  1 Apr 2017
ISSN
  1435-232X (electronic)
  1434-5161
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative 
disorder caused by survival motor neuron gene mutations. Variant forms of 
SMA accompanied by additional clinical presentations have been classified as 
atypical SMA and are thought to be caused by variants in as yet unidentified 
causative genes. Here, we presented the clinical findings of two siblings 
with an SMA variant followed by progressive cerebral atrophy, and the 
results of whole-exome sequencing analyses of the family quartet that was 
performed to identify potential causative variants. We identified two 
candidate homozygous missense variants, R942Q in the tubulin-folding 
cofactor D (TBCD) gene and H250Q in the bromo-adjacent homology domain and 
coiled-coil containing 1 (BAHCC1) gene, located on chromosome 17q25.3 with 
an interval of 1.4 Mbp. The in silico analysis of both variants suggested 
that TBCD rather than BAHCC1 was likely the pathogenic gene (TBCD 
sensitivity, 0.68; specificity, 0.97; BAHCC1 sensitivity, 1.00; specificity, 
0.00). Thus, our results show that TBCD is a likely novel candidate gene for 
atypical SMA with progressive cerebral atrophy. TBCD is predicted to have 
important functions on tubulin integrity in motor neurons as well as in the 
central nervous system.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  tubulin (endogenous compound); tubulin folding cofactor D (endogenous compound); 
EMTREE DRUG INDEX TERMS
  anticonvulsive agent (drug therapy); bromo adjacent homology domain and coiled coil containing 1 protein; unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  nerve degeneration; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  article; brain atrophy; case report; chromosome 17q; computer assisted tomography; computer model; controlled study; developmental disorder; dysphagia; dystocia; failure to thrive; fasciculation; female; focal epilepsy (drug therapy); genetic variability; genotype; gestational age; hepatosplenomegaly; high arched palate; homozygote; human; hypoxemia; immobility; infant; involuntary movement; mental deficiency; missense mutation; motoneuron; muscle hypotonia; muscle weakness; pes equinus; psychomotor retardation; respiratory distress; sensitivity and specificity; sibling; single nucleotide polymorphism; tracheostomy; vaginal delivery; whole exome sequencing; 
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170234315
MEDLINE PMID
  27928163 (http://www.ncbi.nlm.nih.gov/pubmed/27928163)
PUI
  L615063671
DOI
  10.1038/jhg.2016.149
FULL TEXT LINK
  http://dx.doi.org/10.1038/jhg.2016.149
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1435232X&id=doi:10.1038%2Fjhg.2016.149&atitle=TBCD+may+be+a+causal+gene+in+progressive+neurodegenerative+encephalopathy+with+atypical+infantile+spinal+muscular+atrophy&stitle=J.+Hum.+Genet.&title=Journal+of+Human+Genetics&volume=62&issue=4&spage=473&epage=480&aulast=Ikeda&aufirst=Toshio&auinit=T.&aufull=Ikeda+T.&coden=JHGEF&isbn=&pages=473-480&date=2017&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 201
TITLE
  The impact of temperature in aortic arch surgery patients receiving 
antegrade cerebral perfusion for >30 minutes: How relevant is it really?
AUTHOR NAMES
  Preventza O.; Coselli J.S.; Akvan S.; Kashyap S.A.; Garcia A.; Simpson K.H.; Price M.D.; Mayor J.; de la Cruz K.I.; Cornwell L.D.; Omer S.; Bakaeen F.G.; Haywood-Watson R.J.L.; Rammou A.
AUTHOR ADDRESSES
  (Preventza O., opsmile01@aol.com; Coselli J.S.; Akvan S.; Kashyap S.A.; 
Garcia A.; Price M.D.; Mayor J.; de la Cruz K.I.; Cornwell L.D.; Omer S.; 
Bakaeen F.G.; Haywood-Watson R.J.L.) Division of Cardiothoracic Surgery, 
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 
Houston, United States.
(Preventza O., opsmile01@aol.com; Coselli J.S.; de la Cruz K.I.; Bakaeen 
F.G.; Rammou A.) Department of Cardiovascular Surgery, Texas Heart 
Institute, Houston, United States.
(Simpson K.H.; Cornwell L.D.; Omer S.; Bakaeen F.G.) Division of 
Cardiothoracic Surgery, Michael E. DeBakey Veterans Affairs Medical Center, 
Houston, United States.
CORRESPONDENCE ADDRESS
  O. Preventza, BCM 390, One Baylor Plaza, Houston, United States. Email: 
opsmile01@aol.com
AiP/IP ENTRY DATE
  2017-01-19
FULL RECORD ENTRY DATE
  2017-04-12
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2017) 153:4 (767-776). Date 
of Publication: 1 Apr 2017
VOLUME
  153
ISSUE
  4
FIRST PAGE
  767
LAST PAGE
  776
DATE OF PUBLICATION
  1 Apr 2017
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Objective We examined the early outcomes and the long-term survival 
associated with different degrees of hypothermia in patients who received 
antegrade cerebral perfusion (ACP) for >30 minutes. Methods During a 10-year 
period, 544 consecutive patients underwent proximal and total aortic arch 
surgery and received ACP for >30 minutes and 1 of 3 levels of hypothermia: 
deep (14.1°C-20°C; n = 116 [21.3%]), low-moderate (20.1°C-23.9°C; n = 262 
[48.2%]), and high-moderate (24°C-28°C; n = 166 [30.5%]). A variable called 
“predicted temperature” was used in propensity-score analysis. Multivariate 
analysis was done to evaluate the effect of actual temperature on outcomes. 
Results The operative mortality rate was 12.5% (n = 68) overall and was 
15.5%, 11.8%, and 11.5% in the deep, low-moderate, and high-moderate 
hypothermia patients, respectively (P = .54). The persistent stroke rate was 
6.6% overall and 12.2%, 4.6%, and 6.0% in these 3 groups, respectively 
(P = .024 on univariate analysis). On multivariate analysis, actual 
temperature was not associated with mortality, but lower temperatures 
predicted persistent stroke and reoperation for bleeding. In the 
propensity-matched subgroups, the patients with predicted deep hypothermia 
had (nonsignificantly) greater rates of persistent stroke (12.2% vs 4.9%; 
relative risk, 1.08; 95% CI, 0.87-1.15) and reoperation for bleeding (14.6% 
vs 2.4%; relative risk, 1.14; 95% CI, 0.87-1.15) than the patients with 
predicted moderate hypothermia. On long-term follow-up (mean duration, 
5.12 years), 4- and 8-year survival rates were 62.3% and 55.7% in the deep 
hypothermia group and 75.4% and 74.2% in the moderate hypothermia group 
(P = .0015). Conclusions In proximal and arch operations involving ACP for 
>30 minutes, greater actual temperatures were associated with less stroke 
and reoperation for bleeding. There were no significant differences among 
the predicted hypothermia levels, although a trend toward a higher rate of 
adverse events was noticed in the deep hypothermia group. Long-term survival 
was better in the moderate hypothermia group.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  antegrade cerebral perfusion; aortic arch surgery; brain perfusion; hypothermia (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; adverse outcome; aged; aortic dissection; aortic root surgery; aortic valve replacement; cerebrovascular accident (complication); conference paper; controlled study; coronary artery bypass graft; disease duration; endocarditis (complication); extracorporeal oxygenation; female; follow up; human; kidney failure (complication); long term survival; major clinical study; male; mortality rate; multiple organ failure (complication); neurologic disease (complication); operative blood loss (complication, surgery); paraplegia (complication); pericardiotomy; postoperative inflammation (complication); priority journal; reoperation; risk factor; spinal cord injury (complication); surgical mortality; survival rate; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170044044
PUI
  L614075934
DOI
  10.1016/j.jtcvs.2016.11.059
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2016.11.059
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2016.11.059&atitle=The+impact+of+temperature+in+aortic+arch+surgery+patients+receiving+antegrade+cerebral+perfusion+for+%3E30%C2%A0minutes%3A+How+relevant+is+it+really%3F&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=153&issue=4&spage=767&epage=776&aulast=Preventza&aufirst=Ourania&auinit=O.&aufull=Preventza+O.&coden=JTCSA&isbn=&pages=767-776&date=2017&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 202
TITLE
  Complications of spinal cord injuries: Two case reports and a review of the 
literature
ORIGINAL (NON-ENGLISH) TITLE
  Spinal cord yaralanmalarında komplikasyonlar: İki olgu sunumu ve literatür 
derlemesi
AUTHOR NAMES
  Karabacak P.; Gülsoy K.Y.; Osmanlioglu H.O.; Yavuz L.
AUTHOR ADDRESSES
  (Karabacak P.; Gülsoy K.Y., kemalgulsoy@gmail.com; Osmanlioglu H.O.; Yavuz 
L.) Department of Anesthesiology and Reanimation, Suleyman Demirel 
University, Faculty of Medicine, Isparta, Turkey.
CORRESPONDENCE ADDRESS
  K.Y. Gülsoy, Department of Anesthesiology and Reanimation, Suleyman Demirel 
University, Faculty of Medicine, Isparta, Turkey. Email: 
kemalgulsoy@gmail.com
AiP/IP ENTRY DATE
  2016-11-30
FULL RECORD ENTRY DATE
  2016-12-20
SOURCE
  Journal of Clinical and Analytical Medicine (2017) 8:2 (168-171). Date of 
Publication: 1 Mar 2017
VOLUME
  8
ISSUE
  2
FIRST PAGE
  168
LAST PAGE
  171
DATE OF PUBLICATION
  1 Mar 2017
ISSN
  1309-2014 (electronic)
  1309-0720
BOOK PUBLISHER
  Journal of Clinical and Analytical Medicine, secretary@jcam.com.tr
ABSTRACT
  Spinal cord injuries are a health problem that affects many systems and 
leads to physical restrictions associated with the level at which the spinal 
cord is affected. It may be necessary to maintain early and late-stage 
treatment under intensive care conditions according to the degree of 
dysfunction that develops as a result of the level affected in the spinal 
cord. With the appropriate early treatment,survival increases in these 
patients. However,care must be taken with respect to complications that may 
develop while the patient is undergoing treatment and intervention must be 
made for these complications to provide patient comfort. In this paper,we 
present two cases of patients with cervical fractures who developed 
cardiovascular and respiratory problems while in the intensive care unit.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); atropine (drug therapy); dopamine (drug therapy); nitrate (drug therapy); quetiapine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cardiovascular disease (complication); respiratory tract disease (complication); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial heart pacemaker; artificial ventilation; bacterial endocarditis (drug therapy); bradycardia (complication, drug therapy); breathing exercise; case report; cervical spine fracture (diagnosis, surgery); computer assisted tomography; death; deterioration; drug substitution; drug withdrawal; falling; fever; heart arrest (complication); human; hypertension (complication, drug therapy); hypotension (drug therapy); intensive care; male; percutaneous endoscopic gastrostomy; pneumonia (complication); pulmonary aspiration (complication); quadriplegia; review; sedation; sepsis; septic shock; spine stabilization; tracheostomy; unconsciousness; urinary tract infection; 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  dopamine (51-61-6, 62-31-7)
  nitrate (14797-55-8)
  quetiapine (111974-72-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, Turkish
EMBASE ACCESSION NUMBER
  20160858299
PUI
  L613365146
DOI
  10.4328/JCAM.4818
FULL TEXT LINK
  http://dx.doi.org/10.4328/JCAM.4818
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13092014&id=doi:10.4328%2FJCAM.4818&atitle=Complications+of+spinal+cord+injuries%3A+Two+case+reports+and+a+review+of+the+literature&stitle=J.+Clin.+Anal.+Med.&title=Journal+of+Clinical+and+Analytical+Medicine&volume=8&issue=2&spage=168&epage=171&aulast=Karabacak&aufirst=P%C4%B1nar&auinit=P.&aufull=Karabacak+P.&coden=&isbn=&pages=168-171&date=2017&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 203
TITLE
  Anesthetic considerations for patients with acute cervical spinal cord 
injury
AUTHOR NAMES
  Bao F.-P.; Zhang H.-G.; Zhu S.-M.
AUTHOR ADDRESSES
  (Bao F.-P.; Zhang H.-G., zhg1979@hotmail.com; Zhu S.-M.) Department of 
Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang 
University, Hangzhou, China.
CORRESPONDENCE ADDRESS
  H.-G. Zhang, Department of Anesthesiology, First Affiliated Hospital, 
College of Medicine, Zhejiang University, Hangzhou, China. Email: 
zhg1979@hotmail.com
AiP/IP ENTRY DATE
  2017-05-02
FULL RECORD ENTRY DATE
  2017-05-05
SOURCE
  Neural Regeneration Research (2017) 12:3 (499-504). Date of Publication: 1 
Mar 2017
VOLUME
  12
ISSUE
  3
FIRST PAGE
  499
LAST PAGE
  504
DATE OF PUBLICATION
  1 Mar 2017
ISSN
  1876-7958 (electronic)
  1673-5374
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Anesthesiologists work to prevent or minimize secondary injury of the 
nervous system and improve the outcome of medical procedures. To this end, 
anesthesiologists must have a thorough understanding of pathophysiology and 
optimize their skills and equipment to make an anesthesia plan. 
Anesthesiologists should conduct careful physical examinations of patients 
and consider neuroprotection at preoperative interviews, consider cervical 
spinal cord movement and compression during airway management, and suggest 
awake fiberoptic bronchoscope intubation for stable patients and direct 
laryngoscopy with manual in-line immobilization in emergency situations. 
During induction, anesthesiologists should avoid hypotension and 
depolarizing muscle relaxants. Mean artery pressure should be maintained 
within 85-90 mmHg (1 mmHg = 0.133 kPa; vasoactive drug selection and fluid 
management). Normal arterial carbon dioxide pressure and normal blood 
glucose levels should be maintained. Intraoperative neurophysiological 
monitoring is a useful option. Anesthesiologists should be attentive to 
postoperative respiratory insufficiency (carefully considering postoperative 
extubation), thrombus, and infection. In conclusion, anesthesiologists 
should carefully plan the treatment of patients with acute cervical spinal 
cord injuries to protect the nervous system and improve patient outcome.
EMTREE DRUG INDEX TERMS
  atropine; barbituric acid derivative (adverse drug reaction); benzodiazepine (adverse drug reaction); ethinylestradiol plus norgestimate; isoprenaline (adverse drug reaction); methylprednisolone (drug therapy); propofol (adverse drug reaction); salbutamol (drug therapy); suxamethonium (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; cervical spinal cord injury (disease management); 
EMTREE MEDICAL INDEX TERMS
  article; asthma (drug therapy); bradycardia (side effect); computer assisted tomography; electromyography; Frankel grade; glucose blood level; heart arrest; heart arrhythmia (side effect); heart supraventricular arrhythmia; human; hyperglycemia; hypotension; hypothermia; hypovolemia (side effect); intensive care unit; laryngoscopy; mean arterial pressure; nuclear magnetic resonance imaging; operative blood loss; sinus rhythm; tracheotomy; treatment outcome; urinary tract infection (drug therapy); 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  benzodiazepine (12794-10-4)
  ethinylestradiol plus norgestimate (79871-54-8)
  isoprenaline (299-95-6, 51-30-9, 6700-39-6, 7683-59-2)
  methylprednisolone (6923-42-8, 83-43-2)
  propofol (2078-54-8)
  salbutamol (18559-94-9, 35763-26-9)
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170304751
PUI
  L615713654
DOI
  10.4103/1673-5374.202916
FULL TEXT LINK
  http://dx.doi.org/10.4103/1673-5374.202916
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18767958&id=doi:10.4103%2F1673-5374.202916&atitle=Anesthetic+considerations+for+patients+with+acute+cervical+spinal+cord+injury&stitle=Neural.+Regen.+Res.&title=Neural+Regeneration+Research&volume=12&issue=3&spage=499&epage=504&aulast=Bao&aufirst=Fang-Ping&auinit=F.-P.&aufull=Bao+F.-P.&coden=&isbn=&pages=499-504&date=2017&auinit1=F&auinitm=-P
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 204
TITLE
  Prognostic Differences: Epstein-Barr Virus–Associated Primary Leiomyosarcoma 
of the Spine Versus Spinal Leiomyosarcoma Metastases
AUTHOR NAMES
  Agarwal N.; Hansberry D.R.; Kavi A.; Agarwal P.; Baisre A.; Goldstein I.M.
AUTHOR ADDRESSES
  (Agarwal N.) Department of Neurological Surgery, University of Pittsburgh 
Medical Center, Pittsburgh, United States.
(Agarwal N.; Goldstein I.M., goldstir@njms.rutgers.edu) Department of 
Neurological Surgery, Rutgers New Jersey Medical School, Newark, United 
States.
(Hansberry D.R.) Department of Radiology, Thomas Jefferson University 
Hospital, Philadelphia, United States.
(Kavi A.) Department of Medicine, Mount Sinai School of Medicine, New York, 
United States.
(Agarwal P.) Perelman School of Medicine, University of Pennsylvania, 
Philadelphia, United States.
(Baisre A.) Department of Pathology, Rutgers New Jersey Medical School, 
Newark, United States.
CORRESPONDENCE ADDRESS
  I.M. Goldstein, United States. Email: goldstir@njms.rutgers.edu
AiP/IP ENTRY DATE
  2017-01-30
FULL RECORD ENTRY DATE
  2017-02-01
SOURCE
  World Neurosurgery (2017) 99 (484-490). Date of Publication: 1 Mar 2017
VOLUME
  99
FIRST PAGE
  484
LAST PAGE
  490
DATE OF PUBLICATION
  1 Mar 2017
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Objective The authors studied 6 cases of osseous leiomyosarcoma of the 
spine. Two of these cases were of immunocompromised human immunodeficiency 
virus (HIV)-positive patients with Epstein-Barr virus (EBV)-associated 
primary vertebral leiomyosarcomas. The remaining 4 cases were of patients 
with leiomyosarcoma metastases to the spine. Methods Each patient underwent 
surgical resection of their vertebral mass; however, the patients with the 
EBV-associated tumors had the best postoperative prognosis. Results The 
HIV-positive patients have had no further local recurrence, while the other 
4 patients had rapid local recurrences requiring multiple surgical 
interventions. Furthermore, the patients living with HIV have lived longer 
with fewer leiomyosarcoma-related health complications. Conclusions These 
findings suggest that EBV-associated vertebral leiomyosarcoma is of a less 
aggressive variety than metastatic leiomyosarcoma of the spine.
EMTREE DRUG INDEX TERMS
  dexamethasone (drug therapy, intravenous drug administration); docetaxel (drug combination, drug therapy); gemcitabine (drug combination, drug therapy); ifosfamide (adverse drug reaction, drug combination, drug therapy, drug 
toxicity); mesna (adverse drug reaction, drug combination, drug therapy, drug toxicity); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Epstein Barr virus; Epstein Barr virus infection; leiomyosarcoma (drug therapy, diagnosis, drug therapy, radiotherapy, 
rehabilitation, surgery); spinal cord metastasis (drug therapy, diagnosis, drug therapy, 
rehabilitation, surgery); spinal leiomyosarcoma (drug therapy, diagnosis, drug therapy, radiotherapy, 
rehabilitation, surgery); spine tumor (drug therapy, diagnosis, drug therapy, radiotherapy, 
rehabilitation, surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal hysterectomy; adult; bone metastasis (surgery); cancer combination chemotherapy; cancer palliative therapy; cancer patient; cancer prognosis; cancer radiotherapy; cancer surgery; clinical article; computer assisted tomography; confusion (side effect); controlled study; decompression surgery; disease association; drug safety; drug withdrawal; dysphagia; female; gastrointestinal toxicity (complication); histopathology; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hydronephrosis; in situ hybridization; laminectomy; liver metastasis (drug therapy, surgery); lung metastasis (drug therapy, surgery); male; mediastinum mass; metastasis resection; middle aged; multimodality cancer therapy; multiple cycle treatment; neurotoxicity (side effect); neutropenia (side effect); nuclear magnetic resonance imaging; occupational therapy; physiotherapy; pneumonia; positron emission tomography; positron emission tomography-computed tomography; postoperative period; retroperitoneal tumor (surgery); review; salpingooophorectomy; spinal cord biopsy; spinal cord compression; spinal cord tumor (surgery); spine; spine surgery; thorax radiography; tracheostomy; tumor localization; tumor recurrence; tumor volume; urinary tract infection (complication); vertebra body; 
DRUG TRADE NAMES
  decadron
  gemzar
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
  docetaxel (114977-28-5)
  gemcitabine (103882-84-4)
  ifosfamide (3778-73-2)
  mesna (19767-45-4, 3375-50-6)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170068330
MEDLINE PMID
  28011357 (http://www.ncbi.nlm.nih.gov/pubmed/28011357)
PUI
  L614147101
DOI
  10.1016/j.wneu.2016.12.035
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2016.12.035
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2016.12.035&atitle=Prognostic+Differences%3A+Epstein-Barr+Virus%E2%80%93Associated+Primary+Leiomyosarcoma+of+the+Spine+Versus+Spinal+Leiomyosarcoma+Metastases&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=99&issue=&spage=484&epage=490&aulast=Agarwal&aufirst=Nitin&auinit=N.&aufull=Agarwal+N.&coden=&isbn=&pages=484-490&date=2017&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 205
TITLE
  Resection of the odontoid process through expanded endoscopic endonasal 
approach: Our clinical experience and surgical techniques
AUTHOR NAMES
  Alkherayf F.; Agbi C.; Kilty S.; MacDonald K.; Lamothe A.
AUTHOR ADDRESSES
  (Alkherayf F.; Agbi C.; Kilty S.; MacDonald K.; Lamothe A.) University of 
Ottawa, Ottawa, Canada.
CORRESPONDENCE ADDRESS
  F. Alkherayf, University of Ottawa, Ottawa, Canada.
FULL RECORD ENTRY DATE
  2018-03-20
SOURCE
  Journal of Neurological Surgery Part B: Skull Base (2017) 78 Supplement 1. 
Date of Publication: 1 Mar 2017
VOLUME
  78
DATE OF PUBLICATION
  1 Mar 2017
CONFERENCE NAME
  27th Annual Meeting North American Skull Base Society
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2017-03-03 to 2017-03-05
ISSN
  2193-6331
BOOK PUBLISHER
  Thieme Medical Publishers, Inc.
ABSTRACT
  Introduction: Patients with ventral cervical-medullary compression e.g., 
rheumatoid arthritis patients require anterior decompression of the 
cervico-medullary junction. Resection of the odontoid process can be 
accomplished through expanded endoscopic endonasal approach especially in 
cases of irreducible basilar invagination in which the pathology is situated 
well above the palatine line. Methods: We are presenting our experience at 
the Ottawa Hospital (TOH) and University of Ottawa over the last seven years 
in patients who underwent expanded endoscopic endonasal decompression of 
their cervicomedullary junction. Over the last seven years, 16 patients 
underwent such procedure, those patients with preoperative cervical 
instability underwent posterior fusion of the upper cervical spine to the 
occiput for stabilization at the same surgical setting. Our follow up ranged 
from 9 months to 5 years. Results: All patients presented with severe 
symptoms of myelopathy and some lower cranial nerves dysfunction. All 
patients demonstrated improvement in their symptoms. All patients were 
extubated after recovery from anesthesia and allowed oral food intake the 
next day. None of our patients required tracheostomy. 12.5% experienced 
transient velopharyngeal insufficiency. one patient had CSF leak which was 
successfully treated with lumbar drain. One of our patients developed 
infection from the posterior cervical fusion and required debridement and 
antibiotics treatment. All of our patients were eventually discharged home. 
Postoperative imaging demonstrated excellent decompression of the anterior 
cervicomedullary junction pathology. Conclusions: The expanded endoscopic 
endonasal approach for odontoidectomy should be considered as a minimally 
invasive approach for anterior decompression in selected cases.
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  odontoid process; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesia; case report; cervical spine; clinical article; conference abstract; cranial nerve; debridement; decompression; drain; drug therapy; female; follow up; food intake; human; infection; liquorrhea; lumbar region; palatopharyngeal incompetence; pathology; remission; spinal cord disease; surgery; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L621247418
DOI
  10.1055/s-0037-1600691
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0037-1600691
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21936331&id=doi:10.1055%2Fs-0037-1600691&atitle=Resection+of+the+odontoid+process+through+expanded+endoscopic+endonasal+approach%3A+Our+clinical+experience+and+surgical+techniques&stitle=J.+Neurol.+Surg.+Part+B+Skull+Base&title=Journal+of+Neurological+Surgery+Part+B%3A+Skull+Base&volume=78&issue=&spage=&epage=&aulast=Alkherayf&aufirst=Fahad&auinit=F.&aufull=Alkherayf+F.&coden=&isbn=&pages=-&date=2017&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 206
TITLE
  Comorbidities and complications of spinal fusion for scoliosis
AUTHOR NAMES
  Berry J.G.; Glotzbecker M.; Rodean J.; Leahy I.; Hall M.; Ferrari L.
AUTHOR ADDRESSES
  (Berry J.G., jay.berry@childrens.harvard.edu) Division of General 
Pediatrics, Boston Children's Hospital, Harvard Medical School, 21 Autumn 
St., Boston, United States.
(Glotzbecker M.) Division of Orthopedic Surgery, Department of Surgery, 
United States.
(Leahy I.; Ferrari L.) Department of Anesthesiology, Perioperative, and Pain 
Medicine, Boston Children's Hospital, Harvard Medical School, Boston, United 
States.
(Rodean J.; Hall M.) Children's Hospital Association, Overland Park, United 
States.
CORRESPONDENCE ADDRESS
  J.G. Berry, Division of General Pediatrics, Boston Children's Hospital, 
Harvard Medical School, 21 Autumn St., Boston, United States. Email: 
jay.berry@childrens.harvard.edu
AiP/IP ENTRY DATE
  2017-04-24
FULL RECORD ENTRY DATE
  2017-05-12
SOURCE
  Pediatrics (2017) 139:3 Article Number: e20162574. Date of Publication: 1 
Mar 2017
VOLUME
  139
ISSUE
  3
DATE OF PUBLICATION
  1 Mar 2017
ISSN
  1098-4275 (electronic)
  0031-4005
BOOK PUBLISHER
  American Academy of Pediatrics, 141 Northwest Point Blvd, P.O. Box 927, Elk 
Grove Village, United States.
ABSTRACT
  BACKGROUND AND OBJECTIVES: General pediatricians and hospitalists are 
increasingly summoned to optimize the comorbid conditions of children with 
medical complexity (CMC) undergoing major surgery. We assessed the 
relationship between specific chronic conditions of CMC and hospital 
resource use with spinal fusion for scoliosis, an operation with high cost 
and morbidity. METHODS: Retrospective analysis of 7252 children age ≥5 years 
with an underlying complex chronic condition undergoing spinal fusion 
between January 1, 2010 through December 31, 2014 in 41 children's 
hospitals. Hospital length of stay (LOS), cost, and 30-day readmission rate 
were compared across comorbid conditions by using linear and logistic 
regression accounting for demographic characteristics and clustering of 
patients by hospital. RESULTS: Fifty-nine percent of children had ≥4 
comorbid conditions. As the number of chronic conditions increased from 1-3 
to ≥10, median LOS increased 60% (5 [interquartile range (IQR), 4-7] to 8 
[IQR, 5-13] days); median hospital cost increased 53% ($52 319 [IQR, $37 
937-71 513] to $80 429 [IQR, $58 602-$111 965]); and readmission rates 
increased 293% (5.4% to 15.8%) (P < .001 for all). In multivariable 
analysis, conditions strongly associated with LOS and cost were chronic 
respiratory insufficiency (LOS: +2.1 days; cost: +$12 070; and bladder 
dysfunction (LOS: +0.8 days; cost: +$4014) (P < .001 for all). Readmission 
likelihood was highest with bladder dysfunction (odds ratio, 1.5; 95% 
confidence interval, 1.1-2.0) and epilepsy (odds ratio, 1.2; 95% confidence 
interval, 1.0-1.5). CONCLUSIONS: Chronic respiratory insufficiency, bladder 
dysfunction, and epilepsy had significant associations with hospital 
resource use for CMC undergoing spinal fusion. Pediatricians, patients, and 
families may find it useful to consider these conditions when striving to 
benefit the children's perioperative health and outcomes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood disease; Children with medical complexity; genetic disorder; muscle disease; scoliosis (surgery); spine fusion; 
EMTREE MEDICAL INDEX TERMS
  adult; article; asthma; bladder dysfunction; brain malformation; cerebral palsy; child; chromosome disorder; chronic disease; chronic respiratory failure; cohort analysis; comorbidity; controlled study; decubitus; dysphagia; epilepsy; female; gastroesophageal reflux; hospital cost; hospital discharge; hospital readmission; human; hydrocephalus; hypertension; length of stay; major clinical study; male; medicaid; medical information system; muscular dystrophy; outcome assessment; respiratory arrest; retrospective study; spinal dysraphism; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170221651
MEDLINE PMID
  28153850 (http://www.ncbi.nlm.nih.gov/pubmed/28153850)
PUI
  L614992647
DOI
  10.1542/peds.2016-2574
FULL TEXT LINK
  http://dx.doi.org/10.1542/peds.2016-2574
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10984275&id=doi:10.1542%2Fpeds.2016-2574&atitle=Comorbidities+and+complications+of+spinal+fusion+for+scoliosis&stitle=Pediatrics&title=Pediatrics&volume=139&issue=3&spage=&epage=&aulast=Berry&aufirst=Jay+G.&auinit=J.G.&aufull=Berry+J.G.&coden=PEDIA&isbn=&pages=-&date=2017&auinit1=J&auinitm=G
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 207
TITLE
  Dysphagia in patients with cervical spinal cord injury: Retrospective study
AUTHOR NAMES
  Cascioli R.; Castellani G.B.; Bosi S.; Fiorani M.; Fontana D.; Locatelli R.
AUTHOR ADDRESSES
  (Cascioli R.; Castellani G.B.; Bosi S.; Fiorani M.; Fontana D.; Locatelli 
R.) Montecatone Rehabilitation Institute, Italy.
CORRESPONDENCE ADDRESS
  R. Cascioli, Montecatone Rehabilitation Institute, Italy.
FULL RECORD ENTRY DATE
  2017-02-27
SOURCE
  Dysphagia (2017) 32:1 (135). Date of Publication: 1 Feb 2017
VOLUME
  32
ISSUE
  1
FIRST PAGE
  135
DATE OF PUBLICATION
  1 Feb 2017
CONFERENCE NAME
  6th European Society for Swallowing Disorders Congress, ESSD 2016
CONFERENCE LOCATION
  Milan, Italy
CONFERENCE DATE
  2016-10-14 to 2016-10-15
ISSN
  1432-0460
BOOK PUBLISHER
  Springer New York LLC
ABSTRACT
  Introduction: It is clinically recognized that patients with a cervical 
lesion of the spinal cord have frequently swallowing problems . Many studies 
have shown that a combination of multiple factors, such as surgical 
approach, mechanical ventilation and presence of tracheotomy, have to be 
considered as risk factors of developing swallowing disorders, although 
every single factor cannot be statistically associated with dysphagia. 
Materials and Methods: A total of 19 patients with cervical spinal cord 
injury (SCI) from Montecatone Rehabilitation Institute were included in our 
study. Respiratory issues and variously mixed factors (prolonged mechanical 
ventilation, tracheotomy, surgical fixation and neck collar) were detected 
in all patients. Theirs swallowing abilities was assessed clinically, by a 
SLP (Logemann 1989) and endoscopically (FEES). Results: Dysphagia was 
identified in 18 patients. BSE has always recorded cough ineffectiveness, 
pharynx sensibility and propulsive wave impairment, but an altered vocal 
quality and food trail at the suctioning have been noticed just 
occasionally. The pharyngeal residue rate was determined precisely just by 
FEES, likewise anatomically pharyngeal alterations due to surgical fixation. 
Thereby a specific therapy (inclusive of neuromuscular treatment and the 
most suitable dietary modifications) has been organized in order to prevent 
pulmonary complications. Currently, 18 patients have sufficient oral caloric 
intake, although some of them need textural dietary restrictions. 
Conclusions: In patients with cervical SCI, complex clinical conditions and 
long hospitalized, an integrate assessment both by means of BSE and FEES 
could be useful in order to estimate as best the post deglutition aspiration 
risk and thereby organized the most suitable behavioural/dietary measures. 
Further analysis is needed to establish specific risk factors such as 
critical illness condition.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; dysphagia; retrospective study; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; aspiration; caloric intake; clinical article; coughing; critical illness; diet restriction; human; lung complication; neck; pharynx; prevention; rehabilitation; risk factor; sensibility; surgery; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L614510547
DOI
  10.1007/s00455-016-9766-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00455-016-9766-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320460&id=doi:10.1007%2Fs00455-016-9766-y&atitle=Dysphagia+in+patients+with+cervical+spinal+cord+injury%3A+Retrospective+study&stitle=Dysphagia&title=Dysphagia&volume=32&issue=1&spage=135&epage=&aulast=Cascioli&aufirst=Roberto&auinit=R.&aufull=Cascioli+R.&coden=&isbn=&pages=135-&date=2017&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 208
TITLE
  Early percutaneous dilational tracheostomy does not lead to an increased 
risk of surgical site infection following anterior spinal surgery
AUTHOR NAMES
  Kaczmarek C.; Aach M.; Hoffmann M.F.; Yilmaz E.; Waydhas C.; Schildhauer T.A.; Hamsen U.
AUTHOR ADDRESSES
  (Kaczmarek C., chris.kaczmarek@hotmail.com; Hoffmann M.F.; Yilmaz E.; 
Schildhauer T.A.; Hamsen U.) Chirurgische Universitätsklinik und Poliklinik, 
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum, Bürkle 
de la Camp Platz 1, Bochum, Germany.
(Aach M.) Abteilung Für Rückenmarksverletzte, Berufsgenossenschaftliches 
Universitätsklinikum Bergmannsheil Bochum, Bochum, Germany.
(Waydhas C.)
CORRESPONDENCE ADDRESS
  C. Kaczmarek, Chirurgische Universitätsklinik und Poliklinik, 
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum, Bürkle 
de la Camp Platz 1, Bochum, Germany. Email: chris.kaczmarek@hotmail.com
AiP/IP ENTRY DATE
  2016-12-05
FULL RECORD ENTRY DATE
  2017-02-14
SOURCE
  Journal of Trauma and Acute Care Surgery (2017) 82:2 (383-386). Date of 
Publication: 1 Feb 2017
VOLUME
  82
ISSUE
  2
FIRST PAGE
  383
LAST PAGE
  386
DATE OF PUBLICATION
  1 Feb 2017
ISSN
  2163-0763 (electronic)
  2163-0755
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  BACKGROUND: Most patients with cervical spinal cord injuries require 
tracheostomy. The optimal timing is still a matter of debate. Previous 
studies showed that patients receiving early tracheostomy had fewer 
ventilator days and decreased rates of pneumonia and were mobilized earlier. 
Because of the proximity of the anterior approach to the tracheostoma, there 
is concern about an increased risk of surgical site infection (SSI) related 
to tracheostomy. METHODS: This was a retrospective analysis at a Level I 
trauma center of patient records from 2008 to 2014, identifying all patients 
with spinal cord injury who received anterior cervical spinal surgery and 
had early percutaneous dilational tracheostomy (PDT). Follow-up for SSI was 
performed throughout hospital stay (mean, 110 days; median, 96 days, with 
lower quartile 89 days and upper quartile 119 days) and at 6 weeks and 3 
months (clinical examination and computed tomography scans). RESULTS: 
Fifty-one patients underwent anterior spinal surgery with PDT performed 
within a median of 5 days (range, 1-18 days). Seventy-eight percent (n = 40) 
of patients had anterior spinal surgery, whereas 22% (n = 11) had a combined 
anterior-posterior repair. All percutaneous dilational tracheostomies were 
performed using the Ciaglia single-step dilation technique. Despite an SSI 
of one patient's cannulation site, no SSI of the anterior approach was 
observed. CONCLUSION: Performing a PDT in a timely fashion after anterior 
spinal surgery does not increase the risk of SSI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spinal surgery; infection risk; spine surgery; surgical infection; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; clinical examination; computer assisted tomography; conference paper; emergency health service; female; follow up; hospitalization; human; intervertebral disk degeneration (surgery); major clinical study; male; medical record; middle aged; neurological surgical equipment; orthopedic surgical equipment; priority journal; retrospective study; spinal cord injury (surgery); surgical intensive care unit; 
DEVICE TRADE NAMES
  Ciaglia Blue Rhino  , United StatesCook Medical

DEVICE MANUFACTURERS
   (United States)Cook Medical
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160873817
MEDLINE PMID
  27893643 (http://www.ncbi.nlm.nih.gov/pubmed/27893643)
PUI
  L613475791
DOI
  10.1097/TA.0000000000001320
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0000000000001320
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0000000000001320&atitle=Early+percutaneous+dilational+tracheostomy+does+not+lead+to+an+increased+risk+of+surgical+site+infection+following+anterior+spinal+surgery&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=82&issue=2&spage=383&epage=386&aulast=Kaczmarek&aufirst=Chris&auinit=C.&aufull=Kaczmarek+C.&coden=&isbn=&pages=383-386&date=2017&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 209
TITLE
  Erratum: Early percutaneous dilational tracheostomy does not lead to an 
increased risk of surgical site infection following anterior spinal surgery 
(Journal of Trauma and Acute Care Surgery (2017) 82:2 (383-386) DOI: 
10.1097/TA.0000000000001320)
AUTHOR ADDRESSES
  AiP/IP ENTRY DATE
  2018-04-11
FULL RECORD ENTRY DATE
  2018-05-04
SOURCE
  Journal of Trauma and Acute Care Surgery (2018) 84:4 (679). Date of 
Publication: 1 Apr 2018
VOLUME
  84
ISSUE
  4
FIRST PAGE
  679
DATE OF PUBLICATION
  1 Apr 2018
ISSN
  2163-0763 (electronic)
  2163-0755
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  In the 82(2) issue of the journal, published in February 2017, the 
Authorship section of this article should read as follows: CK designed the 
study collected the data and drafted themanuscript. UH designed the study, 
collected the data and revised the manuscript. CWhelped with the study 
design, revised the study, and helped with the literature review. EY helped 
with the data collection and revised the manuscript.MFH helped with the 
study design and revised themanuscript.MArevised the manuscript. TAS 
coordinated the study and helped with the study design. All authors read and 
approved the final manuscript. This correction has been noted in the online 
version of the article, which is available at www.jtrauma.com.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  error; 
EMTREE MEDICAL INDEX TERMS
  erratum; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  29557919 (http://www.ncbi.nlm.nih.gov/pubmed/29557919)
PUI
  L621568937
DOI
  10.1097/01.ta.0000532141.98415.ac
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ta.0000532141.98415.ac
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2F01.ta.0000532141.98415.ac&atitle=Erratum%3A+Early+percutaneous+dilational+tracheostomy+does+not+lead+to+an+increased+risk+of+surgical+site+infection+following+anterior+spinal+surgery+%28Journal+of+Trauma+and+Acute+Care+Surgery+%282017%29+82%3A2+%28383-386%29+DOI%3A+10.1097%2FTA.0000000000001320%29&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=84&issue=4&spage=679&epage=&aulast=&aufirst=&auinit=&aufull=&coden=&isbn=&pages=679-&date=2018&auinit1=&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 210
TITLE
  Cough augmentation techniques for extubation or weaning critically ill 
patients from mechanical ventilation
AUTHOR NAMES
  Rose L.; Adhikari N.K.J.; Leasa D.; Fergusson D.A.; Mckim D.
AUTHOR ADDRESSES
  (Rose L., louise.rose@utoronto.ca) University of Toronto, Lawrence S. 
Bloomberg Faculty of Nursing, 155 College St, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.J.) University of Toronto, 
Interdepartmental Division of Critical Care, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca) Toronto East General Hospital, Provincial 
Weaning Centre of Excellence, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.J.) Sunnybrook Health 
Sciences Centre, Department of Critical Care Medicine and Sunnybrook 
Research Institute, Toronto, Canada.
(Leasa D.) London Health Sciences Centre, Critical Care, Department of 
Medicine, 339 Windermere Road, London, Canada.
(Fergusson D.A.) Ottawa Hospital Research Institute, Clinical Epidemiology 
Program, 501 Smyth Road, Ottawa, Canada.
(Mckim D.) Ottawa Hospital, Respiratory Rehabilitation and Sleep Centre, 501 
Smyth Rd, Ottawa, Canada.
CORRESPONDENCE ADDRESS
  L. Rose, University of Toronto, Lawrence S. Bloomberg Faculty of Nursing, 
155 College St, Toronto, Canada. Email: louise.rose@utoronto.ca
AiP/IP ENTRY DATE
  2017-01-19
FULL RECORD ENTRY DATE
  2017-01-24
SOURCE
  Cochrane Database of Systematic Reviews (2017) 2017:1 Article Number: 
CD011833. Date of Publication: 11 Jan 2017
VOLUME
  2017
ISSUE
  1
DATE OF PUBLICATION
  11 Jan 2017
ISSN
  1361-6137 (electronic)
  1469-493X
BOOK PUBLISHER
  John Wiley and Sons Ltd, Southern Gate, Chichester, West Sussex, United 
Kingdom.
ABSTRACT
  Background: There are various reasons why weaning and extubation failure 
occur, but ineffective cough and secretion retention can play a significant 
role. Cough augmentation techniques, such as lung volume recruitment or 
manually- and mechanically-assisted cough, are used to prevent and manage 
respiratory complications associated with chronic conditions, particularly 
neuromuscular disease, and may improve short- and long-term outcomes for 
people with acute respiratory failure. However, the role of cough 
augmentation to facilitate extubation and prevent post-extubation 
respiratory failure is unclear. Objectives: Our primary objective was to 
determine extubation success using cough augmentation techniques compared to 
no cough augmentation for critically-ill adults and children with acute 
respiratory failure admitted to a high-intensity care setting capable of 
managing mechanically-ventilated people (such as an intensive care unit, 
specialized weaning centre, respiratory intermediate care unit, or 
high-dependency unit). Secondary objectives were to determine the effect of 
cough augmentation techniques on reintubation, weaning success, mechanical 
ventilation and weaning duration, length of stay (high-intensity care 
setting and hospital), pneumonia, tracheostomy placement and tracheostomy 
decannulation, and mortality (high-intensity care setting, hospital, and 
after hospital discharge). We evaluated harms associated with use of cough 
augmentation techniques when applied via an artificial airway (or 
non-invasive mask once extubated/decannulated), including haemodynamic 
compromise, arrhythmias, pneumothorax, haemoptysis, and mucus plugging 
requiring airway change and the type of person (such as those with 
neuromuscular disorders or weakness and spinal cord injury) for whom these 
techniques may be efficacious. Search methods: We searched the Cochrane 
Central Register of Controlled Trials (CENTRAL; Issue 4, 2016), MEDLINE 
(OvidSP) (1946 to April 2016), Embase (OvidSP) (1980 to April 2016), CINAHL 
(EBSCOhost) (1982 to April 2016), and ISI Web of Science and Conference 
Proceedings. We searched the PROSPERO and Joanna Briggs Institute databases, 
websites of relevant professional societies, and conference abstracts from 
five professional society annual congresses (2011 to 2015). We did not 
impose language or other restrictions. We performed a citation search using 
PubMed and examined reference lists of relevant studies and reviews. We 
contacted corresponding authors for details of additional published or 
unpublished work. We searched for unpublished studies and ongoing trials on 
the International Clinical Trials Registry Platform 
(apps.who.int/trialsearch) (April 2016). Selection criteria: We included 
randomized and quasi-randomized controlled trials that evaluated cough 
augmentation compared to a control group without this intervention. We 
included non-randomized studies for assessment of harms. We included studies 
of adults and of children aged four weeks or older, receiving invasive 
mechanical ventilation in a high-intensity care setting. Data collection and 
analysis: Two review authors independently screened titles and abstracts 
identified by our search methods. Two review authors independently evaluated 
full-text versions, independently extracted data and assessed risks of bias. 
Main results: We screened 2686 citations and included two trials enrolling 
95 participants and one cohort study enrolling 17 participants. We assessed 
one randomized controlled trial as being at unclear risk of bias, and the 
other at high risk of bias; we assessed the non-randomized study as being at 
high risk of bias. We were unable to pool data due to the small number of 
studies meeting our inclusion criteria and therefore present narrative 
results rather than meta-analyses. One trial of 75 participants reported 
that extubation success (defined as no need for reintubation within 48 
hours) was higher in the mechanical insufflation-exsufflation (MI-E) group 
(82.9% versus 52.5%, P < 0.05) (risk ratio (RR) 1.58, 95% confidence 
interval (CI) 1.13 to 2.20, very low-quality evidence). No study reported 
weaning success or reintubation as distinct from extubation success. One 
trial reported a statistically significant reduction in mechanical 
ventilation duration favouring MI-E (mean difference -6.1 days, 95% CI -8.4 
to -3.8, very low-quality evidence). One trial reported mortality, with no 
participant dying in either study group. Adverse events (reported by two 
trials) included one participant receiving the MI-E protocol experiencing 
haemodynamic compromise. Nine (22.5%) of the control group compared to two 
(6%) MI-E participants experienced secretion encumbrance with severe 
hypoxaemia requiring reintubation (RR 0.25, 95% CI 0.06 to 1.10). In the 
lung volume recruitment trial, one participant experienced an elevated blood 
pressure for more than 30 minutes. No participant experienced new-onset 
arrhythmias, heart rate increased by more than 25%, or a pneumothorax. For 
outcomes assessed using GRADE, we based our downgrading decisions on unclear 
risk of bias, inability to assess consistency or publication bias, and 
uncertainty about the estimate of effect due to the limited number of 
studies contributing outcome data. Authors' conclusions: The overall quality 
of evidence on the efficacy of cough augmentation techniques for 
critically-ill people is very low. Cough augmentation techniques when used 
in mechanically-ventilated critically-ill people appear to result in few 
adverse events.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute respiratory failure; coughing; extubation; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; breathing exercise; controlled clinical trial (topic); critically ill patient; depressed blood pressure; elevated blood pressure; heart arrhythmia; hemoptysis; human; length of stay; lung volume; mortality rate; noninvasive ventilation; pneumothorax; priority journal; randomized controlled trial (topic); review; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170044405
MEDLINE PMID
  28075489 (http://www.ncbi.nlm.nih.gov/pubmed/28075489)
PUI
  L614020981
DOI
  10.1002/14651858.CD011833.pub2
FULL TEXT LINK
  http://dx.doi.org/10.1002/14651858.CD011833.pub2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13616137&id=doi:10.1002%2F14651858.CD011833.pub2&atitle=Cough+augmentation+techniques+for+extubation+or+weaning+critically+ill+patients+from+mechanical+ventilation&stitle=Cochrane+Database+Syst.+Rev.&title=Cochrane+Database+of+Systematic+Reviews&volume=2017&issue=1&spage=&epage=&aulast=Rose&aufirst=Louise&auinit=L.&aufull=Rose+L.&coden=&isbn=&pages=-&date=2017&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 211
TITLE
  QUAD fever: Beware of non-infectious fever in high spinal cord injuries
AUTHOR NAMES
  Goyal J.; Jha R.; Bhatia P.; Mani R.K.
AUTHOR ADDRESSES
  (Goyal J.; Jha R.; Bhatia P.) Internal Medicine, Nayati Medicity Mathura, 
Mathura, India.
(Mani R.K., raj.rkmjs@gmail.com) Pulmonology Critical Care, Nayati 
Multisuperspeciality Hospital, Mathura, India.
CORRESPONDENCE ADDRESS
  R.K. Mani, Pulmonology Critical Care, Nayati Multisuperspeciality Hospital, 
Mathura, India. Email: raj.rkmjs@gmail.com
AiP/IP ENTRY DATE
  2017-06-26
FULL RECORD ENTRY DATE
  2017-06-30
SOURCE
  BMJ Case Reports (2017) 2017 Article Number: bcr-2017-219937. Date of 
Publication: 2017
VOLUME
  2017
DATE OF PUBLICATION
  2017
ISSN
  1757-790X (electronic)
BOOK PUBLISHER
  BMJ Publishing Group, subscriptions@bmjgroup.com
ABSTRACT
  A case of cervical spinal cord injury and quadriparesis with prolonged fever 
is being described. Initially, the patient received treatment for 
well-documented catheter-related bloodstream infection. High spiking fever 
returned and persisted with no obvious evidence of infection. The usual 
non-infectious causes too were carefully excluded. QUAD fever or fever due 
to spinal cord injury itself was considered. The pathogenetic basis of QUAD 
fever is unclear but could be attributed to autonomic dysfunction and 
temperature dysregulation. Awareness of this little known condition could 
help in avoiding unnecessary antimicrobial therapy and in more accurate 
prognostication. Unlike several previous reported cases that ended fatally, 
the present case ran a relatively benign course. The spectrum of 
presentations may therefore be broader than hitherto appreciated.
EMTREE DRUG INDEX TERMS
  C reactive protein (endogenous compound); cefoperazone (drug therapy); D dimer (endogenous compound); enoxaparin; hypertensive factor; meropenem (drug therapy); procalcitonin (endogenous compound); sulbactam (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (diagnosis); fever (diagnosis); QUAD fever (diagnosis); quadriplegia (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  abdominal radiography; adult; antibiotic sensitivity; antibiotic therapy; article; blood culture; blood pressure; breathing rate; case report; clinical outcome; computer assisted tomography; deep vein thrombosis; differential diagnosis; drug indication; drug substitution; drug withdrawal; echography; emergency ward; erythrocyte sedimentation rate; extended spectrum beta lactamase producing Escherichia coli; falling; follow up; Glasgow coma scale; heart rate; hospital acquired pneumonia (drug therapy); hospital discharge; human; hyperthyroidism; laboratory test; leukocyte count; limb weakness; male; middle aged; musculoskeletal system examination; neuroimaging; neurologic examination; nuclear magnetic resonance imaging; oxygen saturation; paralysis; priority journal; prophylaxis; protein blood level; spine radiography; thorax radiography; thyroid function test; tracheostomy; treatment duration; treatment response; urinalysis; venous thromboembolism; vital sign; 
CAS REGISTRY NUMBERS
  C reactive protein (9007-41-4)
  cefoperazone (62893-19-0, 62893-20-3)
  enoxaparin (679809-58-6)
  meropenem (96036-03-2)
  procalcitonin (56645-65-9)
  sulbactam (68373-14-8)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170443011
MEDLINE PMID
  28630243 (http://www.ncbi.nlm.nih.gov/pubmed/28630243)
PUI
  L616842679
DOI
  10.1136/bcr-2017-219937
FULL TEXT LINK
  http://dx.doi.org/10.1136/bcr-2017-219937
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1757790X&id=doi:10.1136%2Fbcr-2017-219937&atitle=QUAD+fever%3A+Beware+of+non-infectious+fever+in+high+spinal+cord+injuries&stitle=BMJ+Case+Rep.&title=BMJ+Case+Reports&volume=2017&issue=&spage=&epage=&aulast=Goyal&aufirst=Jyoti&auinit=J.&aufull=Goyal+J.&coden=&isbn=&pages=-&date=2017&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 212
TITLE
  The question of whether or not to perform therapeutic hypothermia: A case of 
neonatal spinal cord injury
AUTHOR NAMES
  Yokoi K.; Kobayashi S.; Muramatsu K.; Suzuki S.; Gotou H.
AUTHOR ADDRESSES
  (Yokoi K., kyoyo0410@yahoo.co.jp; Kobayashi S.; Muramatsu K.; Suzuki S.; 
Gotou H.) Department of Pediatrics, Nagoya City West Medical Center, 1-1-1, 
Hirate-cho, Kita-ku, Nagoya, Japan.
CORRESPONDENCE ADDRESS
  K. Yokoi, Department of Pediatrics, Nagoya City West Medical Center, 1-1-1, 
Hirate-cho, Kita-ku, Nagoya, Japan. Email: kyoyo0410@yahoo.co.jp
AiP/IP ENTRY DATE
  2017-05-02
FULL RECORD ENTRY DATE
  2017-05-05
SOURCE
  Journal of Neonatal-Perinatal Medicine (2017) 10:2 (195-198). Date of 
Publication: 2017
VOLUME
  10
ISSUE
  2
FIRST PAGE
  195
LAST PAGE
  198
DATE OF PUBLICATION
  2017
ISSN
  1878-4429 (electronic)
  1934-5798
BOOK PUBLISHER
  IOS Press, Nieuwe Hemweg 6B, Amsterdam, Netherlands.
ABSTRACT
  Neonatal spinal cord injury is an extremely rare perinatal complication that 
often occurs concurrently with hypoxic ischemic encephalopathy (HIE), 
further complicating diagnosis of spinal cord injury. Although therapeutic 
hypothermia for moderate to severe HIE is widely recommended in Japan, it is 
difficult to determine whether it satisfies the neurological 
findings-related entry criteria in some patients. We describe a female 
infant with neonatal spinal cord injury after forceps delivery, who 
underwent therapeutic hypothermia upon diagnosis of HIE. The Apgar scores 
were 5 at 1 min, 6 at 5 min, and not recorded at 10 min. Blood gas analysis 
of her umbilical artery was not performed. Since respiratory failure, 
hypotonia and the absence of primitive reflexes were found at 2 hours after 
birth, she was initially diagnosed with moderate HIE and underwent a 
therapeutic hypothermia. Magnetic resonance imaging after therapeutic 
hypothermia revealed the spinal cord was narrowed from the lower medulla 
oblongata to the upper cervical cord. Thus she was diagnosed with an upper 
spinal cord injury at that time. Some patients with neonatal spinal cord 
injuries satisfy the criteria for therapeutic hypothermia. When neonates 
with asphyxia present with prolonged respiratory failure and hypotonia, 
spinal cord injury should be considered in the differential diagnosis. Thus, 
an early MRI is vital for the diagnosis of spinal cord injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  induced hypothermia; spinal cord injury (diagnosis, therapy); 
EMTREE MEDICAL INDEX TERMS
  achilles reflex; Apgar score; article; asphyxia; basal ganglion; blood gas analysis; breathing mechanics; case report; electroencephalography; endotracheal intubation; female; fetus distress; fetus movement; forceps delivery; gastrostomy; human; medulla oblongata; muscle hypotonia; neonatal intensive care unit; neuroimaging; newborn; nuclear magnetic resonance imaging; priority journal; respiratory failure; subdural hematoma; tendon reflex; tracheostomy; umbilical artery; umbilical cord blood; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170303742
MEDLINE PMID
  28409761 (http://www.ncbi.nlm.nih.gov/pubmed/28409761)
PUI
  L615711081
DOI
  10.3233/NPM-171695
FULL TEXT LINK
  http://dx.doi.org/10.3233/NPM-171695
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18784429&id=doi:10.3233%2FNPM-171695&atitle=The+question+of+whether+or+not+to+perform+therapeutic+hypothermia%3A+A+case+of+neonatal+spinal+cord+injury&stitle=J.+Neonatal-Perinat.+Med.&title=Journal+of+Neonatal-Perinatal+Medicine&volume=10&issue=2&spage=195&epage=198&aulast=Yokoi&aufirst=K.&auinit=K.&aufull=Yokoi+K.&coden=&isbn=&pages=195-198&date=2017&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 213
TITLE
  Airway obstruction and neurogenic shock due to severe cervical spine injury
AUTHOR NAMES
  Matthews S.; Shenvi C.L.
AUTHOR ADDRESSES
  (Matthews S.; Shenvi C.L., cshenvi@med.unc.edu) University of North Carolina 
at Chapel Hill, Chapel Hill, United States.
CORRESPONDENCE ADDRESS
  C.L. Shenvi, 170 Manning Dr. CB 7594, Chapel Hill, United States. Email: 
cshenvi@med.unc.edu
AiP/IP ENTRY DATE
  2016-11-11
FULL RECORD ENTRY DATE
  2017-03-07
SOURCE
  American Journal of Emergency Medicine (2017) 35:1 (196.e1-196.e2). Date of 
Publication: 1 Jan 2017
VOLUME
  35
ISSUE
  1
FIRST PAGE
  196.e1
LAST PAGE
  196.e2
DATE OF PUBLICATION
  1 Jan 2017
ISSN
  1532-8171 (electronic)
  0735-6757
BOOK PUBLISHER
  W.B. Saunders
EMTREE DRUG INDEX TERMS
  epinephrine (drug therapy, intraosseous drug administration); noradrenalin; phenylephrine; vasopressin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; neurogenic shock (complication); posttraumatic complication (complication); shock (complication); trachea obstruction (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; artery injury; article; blunt trauma; case report; computer assisted tomography; erythrocyte transfusion; Glasgow coma scale; heart arrest (drug therapy); heart ejection fraction; hemorrhagic shock; human; male; oxygenation; priority journal; resuscitation; return of spontaneous circulation; subarachnoid hemorrhage; supraglottic airway device; tracheostomy; traffic accident; vertebral artery; 
DEVICE TRADE NAMES
  King airway device
CAS REGISTRY NUMBERS
  epinephrine (51-43-4, 55-31-2, 6912-68-1)
  noradrenalin (1407-84-7, 51-41-2)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
  vasopressin (11000-17-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160804543
MEDLINE PMID
  27519451 (http://www.ncbi.nlm.nih.gov/pubmed/27519451)
PUI
  L613126789
DOI
  10.1016/j.ajem.2016.06.108
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ajem.2016.06.108
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15328171&id=doi:10.1016%2Fj.ajem.2016.06.108&atitle=Airway+obstruction+and+neurogenic+shock+due+to+severe+cervical+spine+injury&stitle=Am.+J.+Emerg.+Med.&title=American+Journal+of+Emergency+Medicine&volume=35&issue=1&spage=196.e1&epage=196.e2&aulast=Matthews&aufirst=Shannon&auinit=S.&aufull=Matthews+S.&coden=AJEME&isbn=&pages=196.e1-196.e2&date=2017&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 214
TITLE
  Esophago-cutaneous fistula as a late and rare complication of neglected 
infection in anterior cervical plating
AUTHOR NAMES
  Kong Y.M.; Chan S.K.; Foo C.H.; Jafaar M.S.A.; Tan B.B.; Teo Y.Y.; Wong C.C.
AUTHOR ADDRESSES
  (Kong Y.M.; Chan S.K.; Foo C.H.; Jafaar M.S.A.) Department of Orthopaedics, 
Queen Elizebeth Hospital, Kota Kinabalu, Sabah, Malaysia.
(Tan B.B.; Teo Y.Y.) Department of Orthopaedics, University Malaysia Sarawak 
(UNIMAS), Kuching, Sarawak, Malaysia.
(Wong C.C.) Department of Orthopaedics, Sarawak General Hospital, Kuching, 
Sarawak, Malaysia.
CORRESPONDENCE ADDRESS
  Y.M. Kong, Department of Orthopaedics, Queen Elizebeth Hospital, Kota 
Kinabalu, Sabah, Malaysia.
FULL RECORD ENTRY DATE
  2018-07-20
SOURCE
  Malaysian Orthopaedic Journal (2017) 11 Supplement A. Date of Publication: 
2017
VOLUME
  11
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  47th Annual Scientific Meeting of Malaysian Orthopaedic Association, MOA 
2017
CONFERENCE LOCATION
  Kuala Lumpur, Malaysia
CONFERENCE DATE
  2017-05-19 to 2017-05-21
ISSN
  1985-2533
BOOK PUBLISHER
  Malaysian Orthopaedic Association
ABSTRACT
  Introduction: Anterior cervical plating is a common surgery for the 
treatment of spondylosis, myelopathy, radiculopathy, and cervical spine 
trauma. Formation of esophago-cutaneous fistula has a rare incident of less 
than 0.1%(1). Common causes of fistula formation are pressure necrosis; 
loose implants or bone graft; or esophageal injury during operation;(2) but 
in our cases, neglected low grade infection might be the most possible 
cause. We report 2 cases of esophageo-cutaneous fistula after anterior 
cervical plating, in traumatic spine injury patients, with chronic history 
of infection. Case series: Mr A is a 25 years old gentleman with 
quadriplegia following C6 burst fracture. Anterior C6 cervical corpectomy 
and fusion was performed. He was subsequently on tracheostomy and PEG tube. 
2 years later, he presented with fever, productive cough and shortness of 
breath for 2months. On examination, he had an anterior neck wound with pus 
discharge. CT fistulogram revealed esophagocutaneous fistula. He refused 
further surgery and opted conservative management. Mr B is a 22 years old 
gentleman with traumatic C5 burst fracture, treated with anterior C5 
cervical corpectomy and fusion. 2 years later, he presented with chronic 
productive cough for 3 months, associated with low grade fever and 
dysphagia. He also had a discharging sinus from previous operation site. 
Direct laryngoscopy showed anterior cervical plate erosion into posterior 
esophageal wall, and communicated with the anterior neck fistula with 
persistent pus discharge. Anterior cervical plate was removed and posterior 
esophageal wall was repaired by plastic surgery team. Discussion: 
Esophagocutaneous fistula is a rare complication, which are usually 
associated with esophageal injury. As for our case series, the possible 
cause could be chronic neglected infection, along with resultant salivary 
leakage into surrounding soft tissue. This ultimately leads to communication 
of the esophagus with the skin and hence a fistula. Multidisciplinary teams 
approach is recommended in the management of this complication. Conservative 
treatment is suggested for early and small esophageal perforations, whereas 
surgical intervention may be considered for large defects. Elias et al 
recommended all anterior hardware to be removed, and posterior 
instrumentation in case of non fusion(3). In our cases, both patients had 
delay presentation of esophagocutaneous fistula, and chose 2 totally 
different way in managing a similar complication. So far operative 
management have showed immediate of fistula closure. Whereas patient who 
chose conservative management still on daily dressing. Conclusion: 
Esophagocutaneous fistula is a rare complication following anterior cervical 
plating, where neglected infection could be a possible cause. Nevertheless, 
it can be managed conservatively or surgically. Surgery always expedite 
fistula closure.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  pus; skin fistula; 
EMTREE MEDICAL INDEX TERMS
  adult; anterior cervical plate; case report; case study; clinical article; complication; computer; conference abstract; conservative treatment; coughing; dysphagia; dyspnea; esophagus injury; esophagus perforation; female; fever; fistulography; fracture; human; laryngoscopy; male; neck; percutaneous endoscopic gastrostomy tube; plastic surgery; quadriplegia; soft tissue; spine injury; surgery; tracheostomy; wound; young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623051654
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19852533&id=doi:&atitle=Esophago-cutaneous+fistula+as+a+late+and+rare+complication+of+neglected+infection+in+anterior+cervical+plating&stitle=Malays.+Orthop.+J.&title=Malaysian+Orthopaedic+Journal&volume=11&issue=&spage=&epage=&aulast=Kong&aufirst=Y.M.&auinit=Y.M.&aufull=Kong+Y.M.&coden=&isbn=&pages=-&date=2017&auinit1=Y&auinitm=M
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 215
TITLE
  Low cost quality initiatives for management of neurosurgical patients in 
developing nations: Perspective from a tertiary care centre in Pakistan
AUTHOR NAMES
  Rai H.; Waqas M.; Shamim M.
AUTHOR ADDRESSES
  (Rai H., hamidhussainrai@hotmail.com; Waqas M., waqas.muhammad@aku.edu; 
Shamim M., shahzad.shamim@aku.edu) Department of Surgery, Section of 
Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.
CORRESPONDENCE ADDRESS
  M. Shamim, Department of Surgery, Section of Neurosurgery, Aga Khan 
University Hospital, Karachi, Pakistan. Email: shahzad.shamim@aku.edu
AiP/IP ENTRY DATE
  2017-06-14
FULL RECORD ENTRY DATE
  2017-06-20
SOURCE
  Surgical Neurology International (2017) 8:1. Date of Publication: 2017
VOLUME
  8
ISSUE
  1
DATE OF PUBLICATION
  2017
ISSN
  2152-7806 (electronic)
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Background: Targeting resources on cost-effective care strategies is 
pertinent for developing nations, specifically for already burdened 
specialties such as neurosurgery, where without state support and insurance 
companies, expenses are borne by the patient themselves. Methods: This was a 
descriptive review of literary work published by the section of neurosurgery 
at Aga Khan University Hospital, Pakistan. We searched PubMed and CiNAHL 
databases to identify articles, which were then critically analyzed and 
discussed from a perspective of low-cost quality care. Results: We 
demonstrate the cost effectiveness of three initiatives, namely, blood 
ordering protocol for elective spine arthrodesis, nonoperative management 
being superior to surgical stabilization in spine injury patients with 
complete neurological deficits, and early tracheostomy in patients with 
isolated severe traumatic brain injury. Conclusion: Initiation and 
implementation of such cost-effective strategies without compromising 
quality health standards must be emphasized by neurosurgical centers 
throughout the developing world for smart allocation and utilization of 
funds.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health care cost; health care quality; 
EMTREE MEDICAL INDEX TERMS
  arthrodesis; article; cost effectiveness analysis; developing country; elective surgery; human; injury severity; major clinical study; Pakistan; priority journal; spine arthrodesis; spine injury (surgery); tertiary care center; tracheostomy; traumatic brain injury; treatment planning; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170418058
PUI
  L616713842
DOI
  10.4103/sni.sni_352_16
FULL TEXT LINK
  http://dx.doi.org/10.4103/sni.sni_352_16
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2Fsni.sni_352_16&atitle=Low+cost+quality+initiatives+for+management+of+neurosurgical+patients+in+developing+nations%3A+Perspective+from+a+tertiary+care+centre+in+Pakistan&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=8&issue=1&spage=&epage=&aulast=Rai&aufirst=Hamid&auinit=H.&aufull=Rai+H.&coden=&isbn=&pages=-&date=2017&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 216
TITLE
  Clinical characteristics and short-term outcome of critical neuro-invasive 
west nile virus infection
AUTHOR NAMES
  Hawkes M.A.; Carabenciov I.D.; Rabinstein A.A.
AUTHOR ADDRESSES
  (Hawkes M.A.; Carabenciov I.D.; Rabinstein A.A.) Department of Neurology, 
Division of Critical Care Neurology, Mayo Clinic, Rochester, United States.
CORRESPONDENCE ADDRESS
  M.A. Hawkes, Department of Neurology, Division of Critical Care Neurology, 
Mayo Clinic, Rochester, United States.
FULL RECORD ENTRY DATE
  2017-11-02
SOURCE
  Neurocritical Care (2017) 27:2 Supplement 1 (S15). Date of Publication: 2017
VOLUME
  27
ISSUE
  2
FIRST PAGE
  S15
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  15th Annual Meeting of the Neurocritical Care Society, NCS 2017
CONFERENCE LOCATION
  Waikoloa, HI, United States
CONFERENCE DATE
  2017-10-10 to 2017-10-13
ISSN
  1556-0961
BOOK PUBLISHER
  Humana Press Inc.
ABSTRACT
  Introduction Neuro-invasive West Nile Virus infection (NI-WNVI) can cause 
cerebral and spinal cord involvement, which can result in critical illness. 
The characteristics and prognosis of patients with NI-WNVI who require ICU 
admission and their prognosis are not well known. Methods Retrospective 
review of patients with diagnosis of NI-WNV treated at Mayo Clinic ICUs from 
1999 to 2016. Demographic data, presenting symptoms, history of 
immunosuppression, diagnostic work-up, hospital length of stay, medical 
complications and modified Rankin Scale (mRs) at discharge were assessed. 
Available follow-up was also reviewed to assess mortality. Results Sixteen 
patients (94% male), aged 57±16 years with NI- WNVI were admitted to the 
ICU. Seven were immunocompromised. Clinical presentations were 
encephalomyelitis (n=11), encephalitis (n=4), and myelitis (n=1). Three 
patients developed coma and 14 required mechanical ventilation. Median 
cells, proteins and glucose in CSF were 70/mm3 (0-698), 101 mg/dl (52-229) 
and 52 mg/dl (32-95) respectively. WNV serology was diagnostic in 15 
patients. CSF antibodies were positive in 9/10 patients. CSF PCR was 
positive in only 1 of 9 patients tested. Brain and spine MRI were abnormal 
in 4/12 and 7/8 patients respectively. Main medical complications were 
pneumonia (n=6), DVT (n= 4), urinary tract infection (n= 2) and 
gastrointestinal bleeding (n=2). Eight patients had tracheostomy and PEG 
tube placement. Median hospital stay was 28 days (5-145). The mRS at 
discharge was 6 (n=1), 5 (n=10), 4(n=3) and 3(n=2). Four additional patients 
died after a median follow-up of 5.3 months (4.1-86). Conclusions The 
short-term prognosis of NI-WNVI requiring ICU care is poor and mortality 
rate is relatively high. More data on the long-term prognosis of these 
patients are needed to guide the goals of care in the acute setting.
EMTREE DRUG INDEX TERMS
  antibody; glucose; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  urinary tract infection; West Nile virus; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; clinical article; coma; complication; demography; diagnosis; encephalitis; encephalomyelitis; female; follow up; gastrointestinal hemorrhage; hospitalization; human; immunosuppressive treatment; length of stay; male; mortality rate; nonhuman; nuclear magnetic resonance imaging; pneumonia; polymerase chain reaction; prognosis; Rankin scale; serology; spine; tracheostomy; 
CAS REGISTRY NUMBERS
  glucose (50-99-7, 84778-64-3)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L619001716
DOI
  10.1007/s12028-017-0465-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12028-017-0465-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15560961&id=doi:10.1007%2Fs12028-017-0465-9&atitle=Clinical+characteristics+and+short-term+outcome+of+critical+neuro-invasive+west+nile+virus+infection&stitle=Neurocrit.+Care&title=Neurocritical+Care&volume=27&issue=2&spage=S15&epage=&aulast=Hawkes&aufirst=Maximiliano+A.&auinit=M.A.&aufull=Hawkes+M.A.&coden=&isbn=&pages=S15-&date=2017&auinit1=M&auinitm=A
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 217
TITLE
  Non-invasive positive pressure ventilation during the management of severe 
spinal muscular atrophy type I
AUTHOR NAMES
  Inoue K.; Kimura N.; Higuchi Y.; Nakamoto M.; Imai T.; Nishio H.
AUTHOR ADDRESSES
  (Inoue K., kenji.s.address@gmail.com; Kimura N.; Higuchi Y.; Nakamoto M.; 
Imai T.) Otsu Red Cross Hospital, Ohtsu, Shiga, Japan.
(Nishio H.) Graduate School of Medicine, Faculty of Medical Sciences, Kobe 
University Graduate School of Medicine, Kobe, Hyogo, Japan.
AiP/IP ENTRY DATE
  2017-05-04
FULL RECORD ENTRY DATE
  2017-08-04
SOURCE
  No To Hattatsu (2017) 49:2 (141-144). Date of Publication: 2017
VOLUME
  49
ISSUE
  2
FIRST PAGE
  141
LAST PAGE
  144
DATE OF PUBLICATION
  2017
ISSN
  0029-0831
BOOK PUBLISHER
  Japanese Society of Child Neurology
ABSTRACT
  Patients with spinal muscular atrophy type (SMA) with the onset before the 
age of 3 months are considered as severe form of SMA (severe SMA) and have 
poor prognosis. Here, we report the efficacy of non-invasive positive 
pressure ventilation(NPPV)in a patient with severe SMA. She was born with 
generalized hypotonia and feeding difficulties, and had SMN1 gene mutations 
(the deletion of exons 7 and 8). At 1 month of age, she was intubated 
because of respiratory failure due to a respiratory tract infection, and 
extubation proved difficult. Her parents decided that NPPV and a mechanical 
in-exsufflator (MI-E) should be used for respiratory management rather than 
a tracheotomy. The NPPV improved her peripheral coldness, cold sweats, chest 
wall movement, and heart rate and enabled her to sleep well. At 1 year and 2 
months, chest computed tomography revealed mild pneumonia and did not show 
any atelectasis. The NPPV facilitated discharge, and the patient had a good 
quality of life (QOL) from the point of view of voice production, the 
ability to move easily, the simplicity of bathing, and the low level of 
discomfort she experienced. However, she suffered repeated episodes of 
aspiration pneumonia and airway obstruction (by sputum) after 11 months of 
age. Thereafter, she required continuous NPPV and high-span inspiratory 
positive airway pressure (21 cmH(2)O). At 1 year and 4 months, she died of 
respiratory failure at home. As her bulbar weakness worsened, respiratory 
management with NPPV became difficult. However, the long-term use of NPPV 
together with high-span positive inspiratory pressure plus positive 
end-expiratory pressure, and a high-pressure MI-E at an early age might 
improve respiratory management outcomes and patient prognosis. In our case, 
NPPV was effective at improving ventilation and preventing atelectasis and 
helped to provide the patient with a good QOL.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  noninvasive ventilation; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  airway obstruction; article; aspiration pneumonia; bulbar paralysis; case report; cold sweat; computer assisted tomography; extubation; female; gene mutation; heart rate; human; muscle hypotonia; pneumonia; quality of life; respiratory failure; respiratory tract infection; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  20170311722
PUI
  L615805608
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00290831&id=doi:&atitle=Non-invasive+positive+pressure+ventilation+during+the+management+of+severe+spinal+muscular+atrophy+type+I&stitle=No+To+Hattatsu&title=No+To+Hattatsu&volume=49&issue=2&spage=141&epage=144&aulast=Inoue&aufirst=Kenji&auinit=K.&aufull=Inoue+K.&coden=NTHAA&isbn=&pages=141-144&date=2017&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 218
TITLE
  Ventilator weaning in cervical level spinal injuries with diaphragmatic 
pacing
AUTHOR NAMES
  Morris M.; Wenzel L.R.
AUTHOR ADDRESSES
  (Morris M.; Wenzel L.R.) TIRR Memorial Hermann Hospital, Houston, United 
States.
(Wenzel L.R.) Baylor College of Medicine, Houston, United States.
CORRESPONDENCE ADDRESS
  M. Morris, TIRR Memorial Hermann Hospital, Houston, United States.
FULL RECORD ENTRY DATE
  2017-09-21
SOURCE
  Journal of Spinal Cord Medicine (2017) 40:5 (625). Date of Publication: 2017
VOLUME
  40
ISSUE
  5
FIRST PAGE
  625
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  American Academy of Spinal Cord Injury Professionals Educational Conference 
2017, ASCIP 2017
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2017-09-03 to 2017-09-06
ISSN
  2045-7723
BOOK PUBLISHER
  Taylor and Francis Ltd.
ABSTRACT
  Objective: We report the cases of several individuals with tetraplegia after 
cervical trauma or injury who subsequently underwent diaphragmatic pacemaker 
implantation to assist with weaning from a ventilator. The individuals 
included in this report were admitted to inpatient rehabilitation with goals 
for general rehabilitation and the possibility of ventilator weaning. The 
individuals we report ultimately underwent diaphragmatic pacemaker 
implantation following injuries that subsequently required tracheostomy and 
ventilator placement. The individuals we report were successively able to 
partially or completely wean from the ventilator with the use of a 
diaphragmatic pacer. We will review the major indications and 
contraindications for diaphragmatic pacing and ventilator weaning processes. 
We will discuss the benefits and barriers noted with diaphragmatic pacing in 
individuals that are ventilator dependent with cervical level spinal cord 
injuries, as well as the general process utilized for ventilator weaning 
with the use of a diaphragmatic pacer. We will explain the roles of various 
healthcare providers that assist with ventilator weaning including 
physicians, respiratory therapists and speech language pathologists. 
Finally, we will highlight the positive outcomes related to ventilator 
weaning in patients with cervical injuries as it relates to improved quality 
of life outcomes. Design: Retrospective research design completed in a 
rehabilitation hospital. Participants/methods: Three individuals with 
tetraplegia were included in a retrospective research study looking at 
weaning from the ventilator with use of a diaphragmatic pacer. All research 
completed was retrospective. Results: All individuals achieved full or 
partial weaning from the ventilator with successful placement of 
diaphragmatic pacers. Conclusion: Diaphragmatic pacers can greatly improve 
quality of life outcomes in individuals with cervical level spinal cord 
injuries.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; diaphragm; ventilator weaning; 
EMTREE MEDICAL INDEX TERMS
  adult; case report; female; health care personnel; hospital patient; human; pacemaker implantation; quadriplegia; quality of life; rehabilitation; respiratory therapist; retrospective study; speech language pathologist; spinal cord injury; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L618304188
DOI
  10.1080/10790268.2017.1351706
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2017.1351706
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2017.1351706&atitle=Ventilator+weaning+in+cervical+level+spinal+injuries+with+diaphragmatic+pacing&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=40&issue=5&spage=625&epage=&aulast=Morris&aufirst=Meggan&auinit=M.&aufull=Morris+M.&coden=&isbn=&pages=625-&date=2017&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 219
TITLE
  Progressive Cervical Spinal Cord Atrophy after a Traffic Accident
AUTHOR NAMES
  Inoue K.; Kumada T.; Fujii T.; Kimura N.
AUTHOR ADDRESSES
  (Inoue K.; Kumada T.; Fujii T.) Department of Pediatrics, Shiga Medical 
Center for Children, Japan.
(Kimura N.) Department of Pediatrics, Japanese Red Cross Otsu Hospital, 
Japan.
AiP/IP ENTRY DATE
  2016-12-13
FULL RECORD ENTRY DATE
  2016-12-30
SOURCE
  Journal of Pediatrics (2017) 180 (287-287.e1). Date of Publication: 1 Jan 
2017
VOLUME
  180
FIRST PAGE
  287
LAST PAGE
  287.e1
DATE OF PUBLICATION
  1 Jan 2017
ISSN
  1097-6833 (electronic)
  0022-3476
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord; spinal cord atrophy; traffic accident; 
EMTREE MEDICAL INDEX TERMS
  anuria; article; case report; child; disease course; female; human; medulla oblongata; muscle strength; nuclear magnetic resonance imaging; patient transport; physical examination; preschool child; priority journal; quadriplegia; spinal cord; swelling; tendon reflex; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160895711
MEDLINE PMID
  27720245 (http://www.ncbi.nlm.nih.gov/pubmed/27720245)
PUI
  L613572351
DOI
  10.1016/j.jpeds.2016.09.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jpeds.2016.09.007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10976833&id=doi:10.1016%2Fj.jpeds.2016.09.007&atitle=Progressive+Cervical+Spinal+Cord+Atrophy+after+a+Traffic+Accident&stitle=J.+Pediatr.&title=Journal+of+Pediatrics&volume=180&issue=&spage=287&epage=287.e1&aulast=Inoue&aufirst=Kenji&auinit=K.&aufull=Inoue+K.&coden=JOPDA&isbn=&pages=287-287.e1&date=2017&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 220
TITLE
  Microorganisms associated with vibrating mesh and jet nebulizers during 
mechanical ventilation in the acute care setting: A randomized controlled 
trial
AUTHOR NAMES
  Dubosky M.N.; Lamorena E.; Jones C.; Roberts K.; Kim Y.; Flaws M.L.; Vines D.L.
AUTHOR ADDRESSES
  (Dubosky M.N., meagan_dubosky@rush.edu; Lamorena E.; Jones C.; Roberts K.; 
Vines D.L.) Rush University Medical Center, Chicago, United States.
(Kim Y.) University of Illinois at Chicago, Chicago, United States.
(Flaws M.L.) Rush University, Chicago, United States.
CORRESPONDENCE ADDRESS
  M.N. Dubosky, Rush University Medical Center, Chicago, United States. Email: 
meagan_dubosky@rush.edu
FULL RECORD ENTRY DATE
  2017-08-15
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2017) 195. Date 
of Publication: 2017
VOLUME
  195
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2017
CONFERENCE LOCATION
  Washington, DC, United States
CONFERENCE DATE
  2017-05-19 to 2017-05-24
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Background: Contaminated nebulizers may spread bacteria to the ventilator 
circuit and lungs. Differences in design and circuit placement between jet 
nebulizer (JN) and vibrating mesh nebulizers (VMN) may influence nebulizer 
contamination and subsequently, the patient. The aim of this research was to 
compare bacterial growth of the nebulizer, ventilator circuit and sputum 
between JNs and VMNs. Methods: A randomized, controlled trial, approved by 
the Institutional Review Board of a Midwest academic medical center. 
Mechanically ventilated adult subjects with an endotracheal tube and a 
physician order for aerosol treatment were randomized to either a JN (Misty 
Max 10™, CareFusion, San Diego, California) or VMN (AeroNeb® Solo, Aerogen, 
Galway, Ireland). Subjects were excluded if intubated for less than 24 
hours, if tracheostomy present on admission, or if diagnosed with 
diaphragmatic paralysis high spinal cord injury, or brain death. JNs were 
placed into a spring loaded t-piece 15 cm from the y-piece and operated at 8 
L/min, and replaced every 3 days. VMNs were placed on the dry side of the 
heater water chamber and changed at end of ventilation, up to 28 days. 
Cultures of aerosol produced by the nebulizers and inspiratory circuit limb 
were obtained and plated every three days and after mechanical ventilation 
ended. A dose of 3 mL of normal saline was nebulized with plume directed 
towards each of 4 agar plates for 1 minute. The 4 agar plates (Remel 
Products, Lenexa, Kansas) included MacConkey, Chocolate, CNA Blood, and 
Sheep blood. Ventilator circuit cultures were collected from the rim of the 
inspiratory limb of the circuit at the y-piece by rubbing a culture swab 
along the circuit in a circular motion three times. Swabs, along with plate 
samples were sealed in a biohazard bag labeled with the subject number and 
sent to the microbiology lab for analysis. Differences in contamination were 
assessed using Chi-square. Results: See Table 1. 120 Subjects were enrolled 
with 30 subjects excluded leaving 48 in the JN and 42 in the VMN groups. 
Conclusions: There was no statistical difference in overall bacteria growth 
between the aerosol produced by the nebulizers. The VMN group had a 
significantly higher growth in the circuit, however no difference was found 
in sputum bacteria growth. Sputum and nebulizer bacteria matched in only one 
subject. Future studies should concentrate on handling practices as a 
primary source of nebulizer contamination.
EMTREE DRUG INDEX TERMS
  sodium chloride; water; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; emergency care; microorganism; nebulizer; nonhuman; 
EMTREE MEDICAL INDEX TERMS
  adult; aerosol; bacterial growth; biosafety; blood; brain death; California; chocolate; contamination; controlled clinical trial; controlled study; diagnosis; diaphragm paralysis; endotracheal tube; female; human; institutional review; Ireland; Kansas; limb; major clinical study; male; microbiology; motion; physician; plume; randomized controlled trial; sheep; spinal cord injury; spring; sputum; tracheostomy; university hospital; ventilator; 
CAS REGISTRY NUMBERS
  sodium chloride (7647-14-5)
  water (7732-18-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617707158
DOI
  10.1164/ajrccm-conference.2017.B24
FULL TEXT LINK
  http://dx.doi.org/10.1164/ajrccm-conference.2017.B24
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:10.1164%2Fajrccm-conference.2017.B24&atitle=Microorganisms+associated+with+vibrating+mesh+and+jet+nebulizers+during+mechanical+ventilation+in+the+acute+care+setting%3A+A+randomized+controlled+trial&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=195&issue=&spage=&epage=&aulast=Dubosky&aufirst=M.N.&auinit=M.N.&aufull=Dubosky+M.N.&coden=&isbn=&pages=-&date=2017&auinit1=M&auinitm=N
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 221
TITLE
  Retrograde intubation in a patient with neglected cervical spine injury for 
sacral advancement flap
AUTHOR NAMES
  Sriramka B.; Pattnaik S.K.
AUTHOR ADDRESSES
  (Sriramka B., bhavna.sriramka@gmail.com; Pattnaik S.K.) Department of 
Anesthesia & Critical Care IMS, SUM Medical College & Hospital, Bhubaneswar, 
India.
CORRESPONDENCE ADDRESS
  B. Sriramka, Department of Anesthesia & Critical Care IMS, SUM Medical 
College & Hospital, Bhubaneswar, India. Email: bhavna.sriramka@gmail.com
AiP/IP ENTRY DATE
  2017-07-13
FULL RECORD ENTRY DATE
  2017-07-14
SOURCE
  Sri Lankan Journal of Anaesthesiology (2017) 25:2 (115-117). Date of 
Publication: 2017
VOLUME
  25
ISSUE
  2
FIRST PAGE
  115
LAST PAGE
  117
DATE OF PUBLICATION
  2017
ISSN
  1391-8834
BOOK PUBLISHER
  College of Anaesthesiologists of Sri Lanka, 44/5A, Gnanartha 
Pradeepaya,Mawatha,, Colombo, Sri Lanka.
ABSTRACT
  Neglected cervical spine injury is a challenging scenario for an 
anaesthetist. Fixed deformities, altered local anatomy, fear of neurological 
worsening makes intubation difficult and prevents use of manoeuvers in 
classical intubation. Advances in equipment like fiberoptic bronchoscope or 
the video laryngoscope aid in such situations. Retrograde intubation (RI) is 
a useful alternative with high success rate in safe and experienced 
personnel. The purpose of the article is to highlight the use of this slowly 
becoming antique technique which becomes quite handy in difficult airway 
situations.
EMTREE DRUG INDEX TERMS
  fentanyl (intravenous drug administration); glycopyrronium (intravenous drug administration); lidocaine; midazolam; neostigmine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; respiratory tract intubation; 
EMTREE MEDICAL INDEX TERMS
  adult; article; body mass; case report; clinical observation; decubitus (surgery); falling; hospital readmission; human; intensive care; laryngoscopy; male; neck malformation; occupational accident; paraplegia; patient positioning; postoperative care; premedication; preoperative evaluation; skin transplantation; thorax injury (surgery); thorax radiography; thorax surgery; tissue flap; tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  glycopyrronium (596-51-0, 1624259-25-1, 740028-90-4)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  neostigmine (114-80-7, 588-17-0, 59-99-4, 8048-84-8)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170492197
PUI
  L617252347
DOI
  10.4038/slja.v25i2.8235
FULL TEXT LINK
  http://dx.doi.org/10.4038/slja.v25i2.8235
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13918834&id=doi:10.4038%2Fslja.v25i2.8235&atitle=Retrograde+intubation+in+a+patient+with+neglected+cervical+spine+injury+for+sacral+advancement+flap&stitle=Sri+Lankan+J.+Anaesthesiol.&title=Sri+Lankan+Journal+of+Anaesthesiology&volume=25&issue=2&spage=115&epage=117&aulast=Sriramka&aufirst=Bhavna&auinit=B.&aufull=Sriramka+B.&coden=&isbn=&pages=115-117&date=2017&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 222
TITLE
  Pulmonary rehabilitation using mechanical insufflation-exsufflation therapy 
for spinal cord injury – Two case studies in the university Malaya medical 
centre
AUTHOR NAMES
  Tan J.H.; Fauzi A.A.; Hasnan N.
AUTHOR ADDRESSES
  (Tan J.H.; Fauzi A.A., aishahaf@ummc.edu.my; Hasnan N.) Department of 
Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Kuala 
Lumpur, Malaysia.
CORRESPONDENCE ADDRESS
  A.A. Fauzi, Department of Rehabilitation Medicine, Faculty of Medicine, 
University of Malaya, Kuala Lumpur, Malaysia. Email: aishahaf@ummc.edu.my
AiP/IP ENTRY DATE
  2018-08-23
FULL RECORD ENTRY DATE
  2018-08-27
SOURCE
  Journal of Health and Translational Medicine (2017) 20:2 (31-33). Date of 
Publication: 2017
VOLUME
  20
ISSUE
  2
FIRST PAGE
  31
LAST PAGE
  33
DATE OF PUBLICATION
  2017
ISSN
  2289-392X (electronic)
  1823-7339
BOOK PUBLISHER
  Faculty of Medicine, University of Malaya, jummec@um.edu.my
ABSTRACT
  There is a high incidence of 36% to 83% of respiratory dysfunction in 
patients with acute cervical spinal cord injury. Complications arising from 
respiratory dysfunction remain one of the most common causes of morbidity 
and mortality in the spinal cord injured population. Specialized pulmonary 
care and therapy can help individuals with tetraplegia to maintain a stable 
respiratory status allowing active participation in active rehabilitation. 
This would allow them to achieve rehabilitation goals of independent 
function and community reintegration. Mechanical insufflation-exsufflation 
(MIE) therapy is an option for secretion management in individuals with 
acute spinal cord injury. In this paper, we present our experience using MIE 
as an adjunct to management of secretions in the spinal cord injured 
population at the University of Malaya Medical Centre.
EMTREE DRUG INDEX TERMS
  bronchodilating agent (drug combination, inhalational drug administration); mucolytic agent (drug combination, inhalational drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  mechanical insufflation exsufflation therapy; pulmonary rehabilitation; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; atelectasis; breathing exercise; bronchoscopy; case report; cervical spine fracture (surgery); clinical article; coughing; distal radius fracture (surgery); falling; fifth cervical vertebra; hospital acquired pneumonia; hospital infection; human; intensive care; Malaysia; male; middle aged; osteosynthesis; peak cough flow; quadriplegia; recurrent infection; respiratory tract parameters; spinal cord transsection; spinal cord tumor (surgery); spine fusion; tracheobronchial toilet; tracheostomy; university hospital; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180567533
PUI
  L623537812
DOI
  10.22452/jummec.vol20no2.5
FULL TEXT LINK
  http://dx.doi.org/10.22452/jummec.vol20no2.5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2289392X&id=doi:10.22452%2Fjummec.vol20no2.5&atitle=Pulmonary+rehabilitation+using+mechanical+insufflation-exsufflation+therapy+for+spinal+cord+injury+%E2%80%93+Two+case+studies+in+the+university+Malaya+medical+centre&stitle=J.+Health+Transl.+Med.&title=Journal+of+Health+and+Translational+Medicine&volume=20&issue=2&spage=31&epage=33&aulast=Tan&aufirst=&auinit=J.H.&aufull=Tan+J.H.&coden=&isbn=&pages=31-33&date=2017&auinit1=J&auinitm=H
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 223
TITLE
  An autopsy case of respiratory failure induced by repetitive cervical spinal 
cord damage due to abnormal movement of the neck in athetoid cerebral palsy
AUTHOR NAMES
  Takei Y.-I.; Koshihara H.; Oguchi K.; Oyanagi K.; Ohara S.
AUTHOR ADDRESSES
  (Takei Y.-I., y1takei@gmail.com; Koshihara H.; Oguchi K.; Ohara S.) 
Department of Neurology, NHO Matsumoto Medical Center, Chushin-Matsumoto 
Hospital, Japan.
(Oyanagi K.) Division of Neuropathology, Department of Brain Disease 
Research, Shinshu University School of Medicine, Japan.
CORRESPONDENCE ADDRESS
  Y.-I. Takei, Department of Neurology, NHO Matsumoto Medical Center, 
Chushin-Matsumoto Hospital, Japan. Email: y1takei@gmail.com
AiP/IP ENTRY DATE
  2017-06-08
FULL RECORD ENTRY DATE
  2017-06-13
SOURCE
  Internal Medicine (2017) 56:11 (1425-1430). Date of Publication: 2017
VOLUME
  56
ISSUE
  11
FIRST PAGE
  1425
LAST PAGE
  1430
DATE OF PUBLICATION
  2017
ISSN
  1349-7235 (electronic)
  0918-2918
BOOK PUBLISHER
  Japanese Society of Internal Medicine
ABSTRACT
  We herein report the clinical and autopsy findings of a 48-year-old 
right-handed man with athetoid cerebral palsy who suffered from cervical 
myelopathy due to abnormal neck movement, and who died of respiratory 
failure. Pathologically, the external appearance of the ventral surface of 
the cervical spinal cord revealed a linear indentation running obliquely at 
the level between the C4 and C5 segments. In the most severely compressed 
lesion, the gray matter was predominantly affected and severely atrophic. 
Microscopically, clusters of oligodendrocytes associated with thinly 
myelinated axons were also observed in the lateral funiculus. The latter 
findings are unique, and could be interpreted as regenerative and/or 
restorative phenomena of the central nervous system following chronic 
repetitive spinal cord compression.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abnormal neck movement; cerebral palsy; cervical spinal cord injury; dyskinesia; respiratory failure; 
EMTREE MEDICAL INDEX TERMS
  adult; arterial gas; article; autopsy; cervical myelopathy; cervical spine radiography; consciousness disorder; constipation; dentate nucleus; fifth cervical vertebra; fourth cervical vertebra; gray matter; human; human tissue; hypercapnia; immunohistochemistry; lung alveolus hypoventilation; lung emphysema; lung fibrosis; male; middle aged; muscle atrophy; muscle weakness; nuclear magnetic resonance imaging; pleura effusion; positive end expiratory pressure; quadriplegia; scoliosis; spinal cord atrophy; spinal cord compression; substantia nigra; tendon reflex; tracheostomy; urine retention; x-ray computed tomography; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170401885
MEDLINE PMID
  28566610 (http://www.ncbi.nlm.nih.gov/pubmed/28566610)
PUI
  L616605441
DOI
  10.2169/internalmedicine.56.7411
FULL TEXT LINK
  http://dx.doi.org/10.2169/internalmedicine.56.7411
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13497235&id=doi:10.2169%2Finternalmedicine.56.7411&atitle=An+autopsy+case+of+respiratory+failure+induced+by+repetitive+cervical+spinal+cord+damage+due+to+abnormal+movement+of+the+neck+in+athetoid+cerebral+palsy&stitle=Intern.+Med.&title=Internal+Medicine&volume=56&issue=11&spage=1425&epage=1430&aulast=Takei&aufirst=Yo-Ichi&auinit=Y.-I.&aufull=Takei+Y.-I.&coden=IEDIE&isbn=&pages=1425-1430&date=2017&auinit1=Y&auinitm=-I
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 224
TITLE
  Multi-disciplinary outpatient care of ventilator-assisted adults in a 
university setting
AUTHOR NAMES
  Brown J.P.; Hanley J.; Rochefort K.; Kurili A.; Schotland H.; Sitrin R.G.
AUTHOR ADDRESSES
  (Brown J.P., browjean@med.umich.edu; Hanley J.; Rochefort K.; Kurili A.; 
Schotland H.; Sitrin R.G.) University of Michigan, Ann Arbor, United States.
CORRESPONDENCE ADDRESS
  J.P. Brown, University of Michigan, Ann Arbor, United States. Email: 
browjean@med.umich.edu
FULL RECORD ENTRY DATE
  2017-08-15
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2017) 195. Date 
of Publication: 2017
VOLUME
  195
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2017
CONFERENCE LOCATION
  Washington, DC, United States
CONFERENCE DATE
  2017-05-19 to 2017-05-24
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Rationale: Due to complex qualifying and documentation requirements and the 
availability of increasingly complex multifunctional devices, input from 
multiple disciplines has become increasingly important to provide effective 
care for ventilator dependent individuals. Complex care in a 
multi-disciplinary clinic environment has been shown to improve quality of 
care and reduce cost of care for diseases such as cystic fibrosis, organ 
transplant and ALS. Methods: IRB approved review of current and former 
patient records. Results: The adult Assisted Ventilation Clinic (AVC) was 
created at U of M in fiscal year 2010 as a multi-disciplinary outpatient 
service to accommodate the needs of patients who would benefit from 
long-term ventilatory support as outpatients. The clinic team is comprised 
of a pulmonologist, respiratory therapist, nurse practitioner, physiatrist, 
neurologist, social worker and a dietitian. Underlying diagnoses in FY 2016 
include spinal cord injury with quadriplegia, ALS, muscular dystrophies and 
myopathies, phrenic nerve injury, and multiple sclerosis. Of these 
diagnoses, spinal cord injury comprises 30% of total patients and ALS is 11% 
of total patients. Approximately 75% of patients in the clinic have a 
diagnosis of a primary neuromuscular disease. Of the remaining patients, 7% 
have a congenital disorder such as cerebral palsy, 3% have a central 
hypoventilation disorder. 10% have complex sleep apnea and obesity 
hypoventilation. Only 4% have COPD or other intrinsic lung disease as the 
primary cause of respiratory failure. 87% of patients are receiving either 
non-invasive or invasive ventilatory support and tracheostomy is present in 
29% of our patients. New patient clinic visits increased from 24 in FY 2010 
to 66 in FY 2016, an increase of 275%. Return visits increased from 175 in 
FY 2010 to 560 in FY 2016, an increase of 320%. By 7/2016, a total of 806 
patients were provided service, with a roster of 502 active patients. 
Conclusions: We conclude that an academic tertiary care center can support a 
large multi-disciplinary outpatient service specializing in the care of 
ventilator-dependent adults. Our outpatient clinic population is primarily 
serving patients with neuromuscular respiratory failure requiring positive 
pressure ventilator support and we have experienced substantial growth in 
both new and return visits over the last four fiscal years. Our data could 
be used to develop comparable services at other institutions to address the 
challenging needs for this complex clinical population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; female; male; outpatient care; university; ventilator; 
EMTREE MEDICAL INDEX TERMS
  adult; assisted ventilation; cerebral palsy; chronic obstructive lung disease; diagnosis; dietitian; human; hypoventilation; major clinical study; medical record; multiple trauma; muscular dystrophy; neurologist; nurse practitioner; obesity; outpatient department; phrenic nerve; physiatrist; pulmonologist; quadriplegia; respiratory failure; respiratory therapist; sclerosis; sleep disordered breathing; social worker; spinal cord injury; tertiary care center; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617706112
DOI
  10.1164/ajrccm-conference.2017.A70
FULL TEXT LINK
  http://dx.doi.org/10.1164/ajrccm-conference.2017.A70
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:10.1164%2Fajrccm-conference.2017.A70&atitle=Multi-disciplinary+outpatient+care+of+ventilator-assisted+adults+in+a+university+setting&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=195&issue=&spage=&epage=&aulast=Brown&aufirst=J.P.&auinit=J.P.&aufull=Brown+J.P.&coden=&isbn=&pages=-&date=2017&auinit1=J&auinitm=P
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 225
TITLE
  Acquired tracheomalacia secondary to excessive cuff inflation
AUTHOR NAMES
  Atchley W.; Kakkera K.; Vilensky V.; Meena N.
AUTHOR ADDRESSES
  (Atchley W., watchley@gmail.com; Kakkera K.; Vilensky V.; Meena N.) 
University of Arkansas for Medical Sciences, Little Rock, United States.
CORRESPONDENCE ADDRESS
  W. Atchley, University of Arkansas for Medical Sciences, Little Rock, United 
States. Email: watchley@gmail.com
FULL RECORD ENTRY DATE
  2017-08-15
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2017) 195. Date 
of Publication: 2017
VOLUME
  195
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2017
CONFERENCE LOCATION
  Washington, DC, United States
CONFERENCE DATE
  2017-05-19 to 2017-05-24
ISSN
  1535-4970
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Acquired tracheomalacia (TM) in the setting of prolonged 
tracheostomy dependence is a potential complication that is thought to 
result from local trauma and resultant tissue injury secondary to elevated 
cuff pressures and intubation injuries. This case highlights a severe 
illustration of TM and its complications in a chronically ventilated 
patient. Case Presentation: A 28 year-old man with medical history 
significant for spinal cord injury and quadriplegia secondary to a gunshot 
wound in 2012 with resulting chronic respiratory failure and tracheostomy 
dependence presented from outside facility for persistent air leak around 
his indwelling tracheostomy. He also was treated for sepsis in the setting 
of recurrent ventilator associated pneumonia with broad-spectrum 
antimicrobials after radiographic findings were consistent with pneumonia. 
The interventional pulmonary service was consulted for evaluation of the 
tracheostomy and trachea after a CT scan revealed apparent severe dilatation 
of the proximal trachea near the site of the tracheostomy cuff. A 
bronchoscopic evaluation via the nasal pathway and trachea was performed 
revealing the trachea to be severely dilated in the area around the balloon 
with signs of complete deterioration of the tracheal rings and formation a 
blind pouch extending outward from the trachea. The trachea distal to the 
tracheostomy site was normal and patent (see figure). The patient's home 
tracheostomy was a Bivona size 8, which the patient inflated with 30cc of 
saline as per his personal preference. After discovery of the 
tracheomalacia, he had a Shiley 8 XLT tracheostomy placed with improvement 
in his air leak. Later this was changed to a Bivona 8.5 120 mm to completely 
bypass the dilatation with continued improvement. Despite the above 
measures, the patient continues to be at high risk for tracheal rupture, 
erosion and aspiration secondary to severely weakened tracheal integrity. 
Discussion: This case highlights a potential serious complication of 
prolonged ventilation via tracheostomies and the danger of hyper-inflating 
the cuff. We recommend that in patients with a requirement for a cuffed 
tracheostomy, the cuff be inflated with the minimal air/saline required to 
safely ventilate the patient.
EMTREE DRUG INDEX TERMS
  sodium chloride; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  pneumatic cuff; tracheomalacia; 
EMTREE MEDICAL INDEX TERMS
  adult; adverse device effect; artificial ventilation; aspiration; balloon; case report; chronic respiratory failure; complication; deterioration; dilatation; gunshot injury; human; male; medical history; patent; quadriplegia; rupture; sepsis; spinal cord injury; tracheostomy; ventilator associated pneumonia; x-ray computed tomography; 
CAS REGISTRY NUMBERS
  sodium chloride (7647-14-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617706194
DOI
  10.1164/ajrccm-conference.2017.A44
FULL TEXT LINK
  http://dx.doi.org/10.1164/ajrccm-conference.2017.A44
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15354970&id=doi:10.1164%2Fajrccm-conference.2017.A44&atitle=Acquired+tracheomalacia+secondary+to+excessive+cuff+inflation&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=195&issue=&spage=&epage=&aulast=Atchley&aufirst=W.&auinit=W.&aufull=Atchley+W.&coden=&isbn=&pages=-&date=2017&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 226
TITLE
  Two cases of ventricular dysrhythmias from aconitine poisoning
AUTHOR NAMES
  Li K.; Vo K.; Repplinger D.; Fouladkou F.; Lynch K.; Smollin C.
AUTHOR ADDRESSES
  (Li K., kai.li@ucsf.edu; Vo K.; Repplinger D.; Fouladkou F.; Lynch K.; 
Smollin C.) University of California San Francisco, United States.
CORRESPONDENCE ADDRESS
  K. Li, University of California San Francisco, United States. Email: 
kai.li@ucsf.edu
FULL RECORD ENTRY DATE
  2017-08-23
SOURCE
  Clinical Toxicology (2017) 55:7 (700). Date of Publication: 2017
VOLUME
  55
ISSUE
  7
FIRST PAGE
  700
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  2017 Annual Meeting of the North American Congress of Clinical Toxicology, 
NACCT 2017
CONFERENCE LOCATION
  Vancouver, BC, Canada
CONFERENCE DATE
  2017-10-11 to 2017-10-15
ISSN
  1556-3650
BOOK PUBLISHER
  Taylor and Francis Ltd
ABSTRACT
  Background: Aconitine is a deterpenoid alkaloid found in plants of the 
Aconitium genus that contain potent cardiovascular and neurological toxins. 
Most reported cases of aconitine poisoning have been related to the use of 
traditional Chinese medications. These herbs are used in the treatment of 
rheumatism, arthritis, and other ailments. Aconitine acts as a 
voltage-sensitive sodium channel opener that results in paresthesias, muscle 
weakness, ventricular ectopic rhythms, heart block and ventricular 
arrhythmias. Case reports: Patient 1: A 56-year-old female presented with 
chest pain and weakness 1 h after preparing and drinking an herbal tea. On 
arrival, she was found to have rapidly evolving tachydysrhythmias including 
bidirectional ventricular tachycardia. She was treated with adenosine, 
diltiazem, cardioversion, amdiodarone, lidocaine, and ultimately developed 
hypotension requiring a dopamine infusion and intubation. Given her 
persistently unstable hemodynamics, she was started on extracorporal 
membrane oxygenation. She had multiple complications including a 
retroperitoneal hemorrhage, right leg ischemia requiring an above the knee 
amputation, spinal cord ischemia with paralysis, and prolonged ventilation 
requiring tracheostomy. The patient died from her complications 
approximately one month after initial presentation. Serum concentrations of 
aconitine on presentation and at 4 h were 3.4 ng/mL and 5.6 ng/mL. Patient 
2: A 36-year-old male presented with paresthesias approximately 1 h after 
preparing and drinking an herbal tea. He had witnessed syncope prior to 
presentation. Clinical course was complicated by rapidly evolving 
tachydysrhythmias including polymorphic ventricular tachycardia, 
superventricular tachycardia, bigeminy, and bidirectional ventricular 
tachycardia. The patient had progressively worsening altered mental status 
and hypotension requiring intubation and norepinephrine. Treatments also 
included calcium, sodium bicarbonate, magnesium, cardioversion, and 
amiodarone. The patient was extubated on hospital day 2, and subsequently 
discharged in good condition. Serum concentration of aconitine was 1.8 ng/mL 
approximately 3.5 h after initial presentation. Case discussion: These two 
patients presented to separate hospitals in the same city within a one-month 
period triggering a public health investigation. Samples of the original 
herbs used in the tea preparations were obtained from each patient's homes 
and also confirmed positive for aconitine. Both products were ultimately 
traced back to the same vendor. Conclusions: Aconitine is commonly used in 
traditional Chinese herbal medicines and is a potential source of 
significant cardiovascular toxicity.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  aconitine; herbaceous agent; 
EMTREE DRUG INDEX TERMS
  adenosine; amiodarone; bicarbonate; calcium; diltiazem; endogenous compound; lidocaine; magnesium; noradrenalin; voltage gated sodium channel; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aconite; heart block; intoxication; nonhuman; 
EMTREE MEDICAL INDEX TERMS
  adult; cardiotoxicity; cardioversion; case report; doctor patient relationship; drinking; drug therapy; extracorporeal oxygenation; faintness; female; heart ventricle arrhythmia; hemodynamics; herbal medicine; herbal tea; human; human tissue; hypotension; intubation; knee amputation; leg ischemia; male; mental health; middle aged; muscle weakness; paralysis; paresthesia; polymorphic ventricular tachycardia; public health; retroperitoneal hemorrhage; spinal cord ischemia; thorax pain; tracheostomy; 
CAS REGISTRY NUMBERS
  aconitine (127-29-7, 302-27-2, 4491-19-4, 6078-26-8, 6846-46-4)
  adenosine (58-61-7)
  amiodarone (1951-25-3, 19774-82-4, 62067-87-2)
  bicarbonate (144-55-8, 71-52-3)
  calcium (7440-70-2, 14092-94-5)
  diltiazem (33286-22-5, 42399-41-7)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  magnesium (7439-95-4)
  noradrenalin (1407-84-7, 51-41-2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617812778
DOI
  10.1080/15563650.2017.1348043
FULL TEXT LINK
  http://dx.doi.org/10.1080/15563650.2017.1348043
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15563650&id=doi:10.1080%2F15563650.2017.1348043&atitle=Two+cases+of+ventricular+dysrhythmias+from+aconitine+poisoning&stitle=Clin.+Toxicol.&title=Clinical+Toxicology&volume=55&issue=7&spage=700&epage=&aulast=Li&aufirst=Kai&auinit=K.&aufull=Li+K.&coden=&isbn=&pages=700-&date=2017&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 227
TITLE
  The results of early surgical decompression and stabilisation for acute 
traumatic spinal cord injury in patients with concomitant chest injuries
AUTHOR NAMES
  Alrawi A.; Sewell M.; Maguire R.; Williams R.; Mecci M.; Prasad M.; Aziz F.; Tizzard S.
AUTHOR ADDRESSES
  (Alrawi A.; Sewell M.; Maguire R.; Mecci M.; Prasad M.; Aziz F.; Tizzard S.) 
James Cook University Hospital, Middlesbrough, United Kingdom.
(Williams R.) Princess Alexandra Hospital, Brisbane, Australia.
CORRESPONDENCE ADDRESS
  A. Alrawi, James Cook University Hospital, Middlesbrough, United Kingdom.
FULL RECORD ENTRY DATE
  2017-03-22
SOURCE
  British Journal of Neurosurgery (2017) 31:2 (126-127). Date of Publication: 
2017
VOLUME
  31
ISSUE
  2
FIRST PAGE
  126
LAST PAGE
  127
DATE OF PUBLICATION
  2017
CONFERENCE NAME
  2017 Spring Meeting of the Society of British Neurological Surgeons
CONFERENCE LOCATION
  Oxford, United Kingdom
CONFERENCE DATE
  2017-03-29 to 2017-03-31
ISSN
  0268-8697
BOOK PUBLISHER
  Taylor and Francis Ltd
ABSTRACT
  Objectives: The benefits of early surgical decompression and stabilisation 
(within 24 hours of injury) for patients with acute traumatic spinal cord 
injury (SCI) is unclear. The objective of this study was to investigate the 
effects of early (<24 hrs of injury) versus late (>24 hrs of injury) 
decompressive and stabilisation surgery for traumatic cervical SCI in 
patients with concomitant chest injuries. Design: Multicentre retrospective 
cohort Subjects: Adults with traumatic cervical SCI, GCS >13 and concomitant 
chest injuries (e.g. haemopneumothoraces, flail chest, multiple rib 
fractures >3 and/or pulmonary contusions) requiring intensive care unit 
(ICU) admission. Methods: Thirty-eight consecutive patients who met the 
inclusion criteria and underwent surgery within 24 hours were compared with 
43 patients who underwent decompressive surgery after 24 hours. The primary 
outcomes were ordinal change in ASIA impairment scale (AIS) at 6 months and 
ICU stay. Secondary outcomes included complications within 30 days and 
requirement for a tracheostomy. Results: In the early surgery group, AIS 
grade improvement was as follows: 21 (55%) no improvement, 13 (34%) had a 1 
grade improvement and 4 (11%) had a 2 grade improvement. Mean ICU stay was 
17 days (3-71). 42% developed a complication and 50% required a 
tracheostomy. In the late surgery group, AIS grade improvement was as 
follows: 28 (65%) no improvement, 13 (30%) had a 1 grade improvement and 2 
(4.5%) had a 2 grade improvement. Mean ICU stay was 24 days (4-68). 53% 
developed a complication and 56% required a tracheostomy. There was one 
mortality in the late surgery group. Conclusions: For patients with acute 
traumatic cervical SCI and concomitant chest trauma, early surgical 
decompression and stabilisation was associated with improved neurological 
outcome, reduced ICU stay and a lower complication rate.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; decompression; thorax injury; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; clinical article; clinical trial; controlled clinical trial; controlled study; flail chest; human; intensive care unit; lung contusion; mortality; multicenter study; surgery; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L614878587
DOI
  10.1080/02688697.2017.1293774
FULL TEXT LINK
  http://dx.doi.org/10.1080/02688697.2017.1293774
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02688697&id=doi:10.1080%2F02688697.2017.1293774&atitle=The+results+of+early+surgical+decompression+and+stabilisation+for+acute+traumatic+spinal+cord+injury+in+patients+with+concomitant+chest+injuries&stitle=Br.+J.+Neurosurg.&title=British+Journal+of+Neurosurgery&volume=31&issue=2&spage=126&epage=127&aulast=Alrawi&aufirst=A.&auinit=A.&aufull=Alrawi+A.&coden=&isbn=&pages=126-127&date=2017&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 228
TITLE
  Spinal complications after tracheal resection with anastomosis for 
cicatricial stenosis
ORIGINAL (NON-ENGLISH) TITLE
  Spinal'nye oslozhneniia posle rezektsii trakhei s formirovaniem anastomoza 
po povodu rubtsovogo stenoza
AUTHOR NAMES
  Parshin V.D.; Isaykin A.I.; Parshin V.V.; Gorshkov K.M.; Nogtev P.V.; Starostin A.V.; Parshin A.V.
AUTHOR ADDRESSES
  (Parshin V.D.; Isaykin A.I.; Parshin V.V.; Gorshkov K.M.; Nogtev P.V.; 
Starostin A.V.; Parshin A.V.) Sechenov First Moscow State Medical University 
of Healthcare Ministry of the Russian Federation, Moscow, Russia
FULL RECORD ENTRY DATE
  2018-04-05
SOURCE
  Khirurgiia (2017) :10 (82-87). Date of Publication: 1 Jan 2017
ISSUE
  10
FIRST PAGE
  82
LAST PAGE
  87
DATE OF PUBLICATION
  1 Jan 2017
ISSN
  0023-1207
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anastomosis; postoperative complication (diagnosis, therapy); spinal cord disease (diagnosis, etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  adolescent; brain; bronchoscopy; case report; diagnostic imaging; female; human; male; neurologic examination; nuclear magnetic resonance imaging; pathophysiology; patient care; procedures; trachea stenosis (diagnosis, surgery); tracheotomy; treatment outcome; young adult; 
LANGUAGE OF ARTICLE
  Russian
MEDLINE PMID
  29076488 (http://www.ncbi.nlm.nih.gov/pubmed/29076488)
PUI
  L621506181
DOI
  10.17116/hirurgia20171082-87
FULL TEXT LINK
  http://dx.doi.org/10.17116/hirurgia20171082-87
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00231207&id=doi:10.17116%2Fhirurgia20171082-87&atitle=Spinal+complications+after+tracheal+resection+with+anastomosis+for+cicatricial+stenosis&stitle=Khirurgiia+%28Mosk%29&title=Khirurgiia&volume=&issue=10&spage=82&epage=87&aulast=Parshin&aufirst=V.D.&auinit=V.D.&aufull=Parshin+V.D.&coden=&isbn=&pages=82-87&date=2017&auinit1=V&auinitm=D
COPYRIGHT
  Copyright 2018 Medline is the source for the citation and abstract of this 
record.

RECORD 229
TITLE
  Biotinidase deficiency mimicking neuromyelitis optica beginning at the age 
of 4: A treatable disease
AUTHOR NAMES
  Girard B.; Bilbault C.; Bonnemains C.; Schmitt E.; Raffo E.
AUTHOR ADDRESSES
  (Girard B., barbara.girard54@gmail.com; Bilbault C.; Raffo E.) Pediatric 
Neurology Unit, Children’s Hospital, University Hospital of Nancy, 
Vandoeuvre-lès-Nancy, France.
(Bonnemains C.) Pediatric Metabolic Unit, Children’s Hospital, University 
Hospital of Nancy, Vandoeuvre-lès-Nancy, France.
(Schmitt E.) Diagnostic and Therapeutic Neuroradiology Department, 
University Hospital of Nancy, Vandoeuvre-lès-Nancy, France.
(Raffo E.) EA 3450 DeVAH, Faculty of Medicine, University of Lorraine, 
Vandoeuvre-lès-Nancy, France.
CORRESPONDENCE ADDRESS
  B. Girard, Pediatric Neurology Unit, Children’s Hospital, University 
Hospital of Nancy, 6 rue du Morvan, Vandoeuvre-lès-Nancy, France. Email: 
barbara.girard54@gmail.com
AiP/IP ENTRY DATE
  2018-05-07
FULL RECORD ENTRY DATE
  2018-05-17
SOURCE
  Multiple Sclerosis Journal (2017) 23:1 (119-122). Date of Publication: 2017
VOLUME
  23
ISSUE
  1
FIRST PAGE
  119
LAST PAGE
  122
DATE OF PUBLICATION
  2017
ISSN
  1477-0970 (electronic)
  1352-4585
BOOK PUBLISHER
  SAGE Publications Ltd, info@sagepub.co.uk
ABSTRACT
  Background: Metabolic and inflammatory conditions may lead to neurological 
disorders. Neuromyelitis optica spectrum disorders (NMOSDs) refer to a rare 
group of demyelinating diseases of the central nervous system which 
essentially involve the optic nerves and spinal cord. Methods: We report a 
case of biotinidase deficiency (BD) initially misdiagnosed as NMOSD in a 
pediatric patient. Results: An 8-year-old girl was initially diagnosed with 
NMOSD on the basis of optic neuritis (ON) associated with three episodes of 
longitudinally extensive transverse myelitis (LETM). Intravenous highdose 
corticosteroids were effective during the first two episodes of LETM. The 
third acute episode which resulted in tetraplegia, respiratory distress, and 
blindness was refractory to corticosteroids, plasmapheresis, and rituximab. 
The unusual clinical course and persistent high levels of plasma and 
cerebrospinal fluid (CSF) lactate led to additional metabolic investigations 
being performed. Acylcarnitine profile revealed increased C5-OH 
acylcarnitine suggestive of BD. Diagnosis was confirmed by direct assessment 
of plasma enzyme activity (quantified as 5% of the control value). Genetic 
analysis revealed two mutations, c.643C>T (p.L215F) and c.1612C>T (p.R538C), 
in the BTD gene (3p25). Dramatic clinical improvement occurred after 
long-term oral biotin treatment. Conclusion: BD is a treatable condition 
that may closely mimic the neurological findings of LETM and NMOSD.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  biotinidase (endogenous compound); 
EMTREE DRUG INDEX TERMS
  biotin (drug therapy, oral drug administration); corticosteroid (drug therapy, intravenous drug administration); gadolinium; immunoglobulin G (endogenous compound); lactic acid (endogenous compound); rituximab (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  biotinidase deficiency (drug therapy, diagnosis, drug therapy); myelooptic neuropathy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  article; blindness (drug therapy); brain radiography; BTD gene; case report; Caucasian; child; chromosome 3p; clinical article; clinical feature; color blindness (diagnosis); correlational study; diagnostic error; disease association; disease course; disease severity; drug efficacy; drug megadose; drug resistance; drug withdrawal; eczema; electrophoresis; endotracheal intubation; enzyme activity; enzyme blood level; eye disease assessment; female; fever; follow up; gene; gene mutation; genetic analysis; hemiparesis; human; immunoglobulin blood level; lactate blood level; long term care; longitudinally extensive transverse myelitis (diagnosis, drug therapy); longitudinally extensive transverse myelitis (drug therapy); lung function; medical history; myelitis (diagnosis, drug therapy); neurologic disease assessment; neuroradiology; nuclear magnetic resonance imaging; optic neuritis; paraplegia; physical examination; plasmapheresis; protein cerebrospinal fluid level; quadriplegia (drug therapy); relapse; respiratory distress (drug therapy, therapy); tracheotomy; treatment duration; urine retention; visual system examination; 
CAS REGISTRY NUMBERS
  biotin (58-85-5)
  biotinidase (9025-15-4)
  gadolinium (7440-54-2)
  immunoglobulin G (97794-27-9)
  lactic acid (113-21-3, 50-21-5)
  rituximab (174722-31-7)
EMBASE CLASSIFICATIONS
  Ophthalmology (12)
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180310649
MEDLINE PMID
  27207447 (http://www.ncbi.nlm.nih.gov/pubmed/27207447)
PUI
  L621952059
DOI
  10.1177/1352458516646087
FULL TEXT LINK
  http://dx.doi.org/10.1177/1352458516646087
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14770970&id=doi:10.1177%2F1352458516646087&atitle=Biotinidase+deficiency+mimicking+neuromyelitis+optica+beginning+at+the+age+of+4%3A+A+treatable+disease&stitle=Mult.+Scler.+J.&title=Multiple+Sclerosis+Journal&volume=23&issue=1&spage=119&epage=122&aulast=Girard&aufirst=Barbara&auinit=B.&aufull=Girard+B.&coden=&isbn=&pages=119-122&date=2017&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 230
TITLE
  Acute transverse myelitis associated with salmonella bacteremia: A case 
report
AUTHOR NAMES
  Richert M.E.; Hosier H.; Weltz A.S.; Wise E.S.; Joshi M.; Diaz J.J.
AUTHOR ADDRESSES
  (Richert M.E.; Hosier H.; Weltz A.S., AdamWeltz@aol.com; Wise E.S.; Diaz 
J.J.) Department of General Surgery, University of Maryland School of 
Medicine, Baltimore, United States.
(Weltz A.S., AdamWeltz@aol.com; Wise E.S.; Diaz J.J.) Department of Surgery, 
R Adams Cowley Shock Trauma Center, Baltimore, United States.
(Joshi M.) Department of Infectious Diseases, R Adams Cowley Shock Trauma 
Center, Baltimore, United States.
CORRESPONDENCE ADDRESS
  A.S. Weltz, Department of General Surgery, University of Maryland School of 
Medicine, Baltimore, United States. Email: AdamWeltz@aol.com
AiP/IP ENTRY DATE
  2016-12-21
FULL RECORD ENTRY DATE
  2017-01-13
SOURCE
  American Journal of Case Reports (2016) 17 (929-933). Date of Publication: 8 
Dec 2016
VOLUME
  17
FIRST PAGE
  929
LAST PAGE
  933
DATE OF PUBLICATION
  8 Dec 2016
ISSN
  1941-5923 (electronic)
BOOK PUBLISHER
  Medical Science International, office@isl-science.com
ABSTRACT
  Objective: Rare disease Background: Acute transverse myelitis (ATM) is an 
uncommon and often overlooked complication of certain bacterial and viral 
infections that can have a rapid onset and result in severe neurological 
deficits. Case Report: This case report describes a previously healthy 
28-year-old woman who presented to the trauma center after developing acute 
paralysis and paresthesias of all four extremities within the span of hours. 
The initial presumptive diagnosis was spinal cord contusion due to a fall 
versus an unknown mechanism of trauma, but eventual laboratory studies 
revealed Salmonella bacteremia, indicating a probable diagnosis of 
parainfectious ATM. Conclusions: This case illustrates the importance of 
considering the diagnosis of parainfectious ATM in patients presenting with 
acute paralysis with incomplete or unobtainable medical histories.
EMTREE DRUG INDEX TERMS
  aquaporin 4 (endogenous compound); ceftriaxone (drug therapy); glucose (endogenous compound); immunoglobulin G (endogenous compound); metronidazole (drug therapy); protein (endogenous compound); vancomycin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute transverse myelitis (diagnosis, etiology); bacteremia (drug therapy, diagnosis, drug therapy, etiology); myelitis (diagnosis, etiology); Salmonella enterica; 
EMTREE MEDICAL INDEX TERMS
  adult; African American; article; bacterial growth; blood culture; case report; computer assisted tomography; disease association; endotracheal intubation; erythrocyte count; falling; female; hospital admission; human; hyperlactatemia; intensive care unit; laboratory test; leukocyte count; lumbar puncture; lymphocyte count; nonhuman; nuclear magnetic resonance imaging; paralysis; paresthesia; plasma exchange; quadriplegia; reference value; respiratory failure (therapy); spinal cord injury (diagnosis); spine fracture (diagnosis); tracheostomy; 
CAS REGISTRY NUMBERS
  aquaporin 4 (175960-54-0)
  ceftriaxone (73384-59-5, 74578-69-1)
  glucose (50-99-7, 84778-64-3)
  immunoglobulin G (97794-27-9)
  metronidazole (39322-38-8, 443-48-1)
  protein (67254-75-5)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160920922
MEDLINE PMID
  27928148 (http://www.ncbi.nlm.nih.gov/pubmed/27928148)
PUI
  L613634567
DOI
  10.12659/AJCR.900730
FULL TEXT LINK
  http://dx.doi.org/10.12659/AJCR.900730
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19415923&id=doi:10.12659%2FAJCR.900730&atitle=Acute+transverse+myelitis+associated+with+salmonella+bacteremia%3A+A+case+report&stitle=Am.+J.+Case+Rep.&title=American+Journal+of+Case+Reports&volume=17&issue=&spage=929&epage=933&aulast=Richert&aufirst=Mary+E.&auinit=M.E.&aufull=Richert+M.E.&coden=&isbn=&pages=929-933&date=2016&auinit1=M&auinitm=E
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 231
TITLE
  A novel method of fixation of tracheostomy tube in cervical spine surgeries 
with posterior approach
AUTHOR NAMES
  Gupta D.; Khandelwal A.; Haldar R.
AUTHOR ADDRESSES
  (Gupta D.; Khandelwal A., ankurchintus@gmail.com; Haldar R.) Department of 
Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, 
Rae Barelly Road, Lucknow, Uttar Pradesh, India.
CORRESPONDENCE ADDRESS
  D. Gupta, Department of Anaesthesiology, Sanjay Gandhi Post Graduate 
Institute of Medical Sciences, Rae Barelly Road, Lucknow, Uttar Pradesh, 
India. Email: ankurchintus@gmail.com
AiP/IP ENTRY DATE
  2017-01-12
FULL RECORD ENTRY DATE
  2017-02-14
SOURCE
  Journal of Neurosciences in Rural Practice (2016) 7:5 Supplement 1 (S123). 
Date of Publication: 1 Dec 2016
VOLUME
  7
ISSUE
  5
FIRST PAGE
  S123
DATE OF PUBLICATION
  1 Dec 2016
ISSN
  0976-3155 (electronic)
  0976-3147
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spine surgery; surgical approach; tracheostomy tube (adverse device effect); EMTREE MEDICAL INDEX TERMS
  absence of complications (complication); human; intermethod comparison; letter; patient positioning; priority journal; procedures; suture technique; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170025107
PUI
  L614004062
DOI
  10.4103/0976-3147.196435
FULL TEXT LINK
  http://dx.doi.org/10.4103/0976-3147.196435
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09763155&id=doi:10.4103%2F0976-3147.196435&atitle=A+novel+method+of+fixation+of+tracheostomy+tube+in+cervical+spine+surgeries+with+posterior+approach&stitle=J.+Neurosci.+Rural+Pract.&title=Journal+of+Neurosciences+in+Rural+Practice&volume=7&issue=5&spage=S123&epage=&aulast=Gupta&aufirst=Devendra&auinit=D.&aufull=Gupta+D.&coden=&isbn=&pages=S123-&date=2016&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 232
TITLE
  Central sleep apnea following cervical spine injury
AUTHOR NAMES
  Pannu A.; Patlak J.; Ciampa E.; Oren-Grinberg A.
AUTHOR ADDRESSES
  (Pannu A.; Patlak J.; Ciampa E.; Oren-Grinberg A.)
CORRESPONDENCE ADDRESS
  A. Pannu,
FULL RECORD ENTRY DATE
  2016-12-08
SOURCE
  Critical Care Medicine (2016) 44:12 Supplement 1 (530). Date of Publication: 
1 Dec 2016
VOLUME
  44
ISSUE
  12
FIRST PAGE
  530
DATE OF PUBLICATION
  1 Dec 2016
CONFERENCE NAME
  46th Critical Care Congress of the Society of Critical Care Medicine, SCCM 
2016
CONFERENCE LOCATION
  Honolulu, HI, United States
CONFERENCE DATE
  2017-01-21 to 2017-01-25
ISSN
  1530-0293
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Learning Objectives: Spinal cord injury (SCI) increases the incidence of 
sleep-disordered breathing (SDB). While loss of diaphragmatic function from 
high cervical lesions is easily recognized, patients with apparently intact 
respiratory function may still suffer from central sleep apnea that can have 
dangerous sequelae. We describe a case of central sleep apnea which 
developed in the acute phase following a cervical SCI. Methods: A previously 
healthy 36 year old man with a BMI of 32 had immediate lower extremity 
paralysis following a diving injury. CT scan revealed jumped facets at C6-7 
bilaterally with anterolisthesis of C6 on C7. He underwent uneventful repair 
of C6-7 fracture dislocation with posterior instrumentation and C3-T2 spinal 
fusion and was easily extubated following the procedure. Postoperative exam 
showed paralysis of the lower extremities with sensory loss below T4. On 
postoperative day 3, he continued to be alert and conversant while awake but 
was noted to have recurrent apneic episodes while asleep. Close observation 
demonstrated no respiratory effort during these episodes and no signs of 
upper airway obstruction. Oxygen saturation fell during these episodes to as 
low as 72% despite supplemental oxygen. Each episode resolved completely 
when the patient was awakened with immediate return of oxygen saturation to 
>96%. Respiratory mechanics were optimized by repositioning the patient 
several times to minimize any airway obstruction and medication review 
revealed no sedating drugs. Non-invasive bilevel positive airway pressure 
(BiPAP) failed to prevent hypoxia during these episodes in the setting of 
absent respiratory effort. Given suspicion for central sleep apnea, elective 
intubation was discussed in detail with the patient who agreed with the 
same. He was intubated and subsequently underwent elective tracheostomy. 
Results: Central sleep apnea is a challenging diagnosis to make in the 
absence of polysomnography testing given the multiple effects of SCI on 
respiratory function. While risk factors remain unclear, patients with 
cervical SCI may present with SDB of central origin.
EMTREE DRUG INDEX TERMS
  oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  central sleep apnea syndrome; cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; airway pressure; body mass; breathing mechanics; clinical article; computer assisted tomography; diagnosis; diving; fracture dislocation; human; hypoxia; intubation; lower limb; male; oxygen saturation; paraplegia; polysomnography; risk factor; sensory dysfunction; spine fusion; surgery; tracheostomy; upper respiratory tract obstruction; wakefulness; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L613521137
DOI
  10.1097/01.ccm.0000510493.11481.de
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000510493.11481.de
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15300293&id=doi:10.1097%2F01.ccm.0000510493.11481.de&atitle=Central+sleep+apnea+following+cervical+spine+injury&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=44&issue=12&spage=530&epage=&aulast=Pannu&aufirst=Ameeka&auinit=A.&aufull=Pannu+A.&coden=&isbn=&pages=530-&date=2016&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 233
TITLE
  Ventilatory Management of the Noninjured Lung
AUTHOR NAMES
  Bowton D.L.; Scott L.K.
AUTHOR ADDRESSES
  (Bowton D.L., dbowton@wakehealth.edu) Section on Critical Care, Department 
of Anesthesiology, Wake Forest Baptist Health, Medical Center Boulevard, 
Winston-Salem, United States.
(Scott L.K.) Departments of Pediatrics and Surgery, Louisiana State 
University Health – Shreveport, 1501 Kings Highway, Shreveport, United 
States.
CORRESPONDENCE ADDRESS
  D.L. Bowton, Section on Critical Care, Department of Anesthesiology, Wake 
Forest Baptist Health, Medical Center Boulevard, Winston-Salem, United 
States. Email: dbowton@wakehealth.edu
AiP/IP ENTRY DATE
  2016-11-07
FULL RECORD ENTRY DATE
  2016-12-14
SOURCE
  Clinics in Chest Medicine (2016) 37:4 (701-710). Date of Publication: 1 Dec 
2016
VOLUME
  37
ISSUE
  4
FIRST PAGE
  701
LAST PAGE
  710
DATE OF PUBLICATION
  1 Dec 2016
ISSN
  1557-8216 (electronic)
  0272-5231
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  This article reviews aspects of mechanical ventilation in patients without 
lung injury, patients in the perioperative period, and those with neurologic 
injury or disease including spinal cord injury. Specific emphasis is placed 
on ventilator strategies, including timing and indications for tracheostomy. 
Lung protective ventilation, using low tidal volumes and modest levels of 
positive end-expiratory pressure, should be the default consideration in all 
patients requiring mechanical ventilatory support. The exception may be the 
patient with high cervical spinal cord injuries who requires mechanical 
ventilatory support. There is no consensus on the timing of tracheostomy in 
patients with neurologic diseases.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; neurologic disease (therapy); 
EMTREE MEDICAL INDEX TERMS
  blood gas; cerebrovascular accident (therapy); human; lung injury (therapy); lung ventilation; neuromuscular disease; organ donor; perioperative period; positive end expiratory pressure; priority journal; review; spinal cord injury (therapy); tidal volume; tracheostomy; traumatic brain injury (therapy); treatment indication; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160789846
MEDLINE PMID
  27842750 (http://www.ncbi.nlm.nih.gov/pubmed/27842750)
PUI
  L612996476
DOI
  10.1016/j.ccm.2016.07.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ccm.2016.07.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15578216&id=doi:10.1016%2Fj.ccm.2016.07.010&atitle=Ventilatory+Management+of+the+Noninjured+Lung&stitle=Clin.+Chest+Med.&title=Clinics+in+Chest+Medicine&volume=37&issue=4&spage=701&epage=710&aulast=Bowton&aufirst=David+L.&auinit=D.L.&aufull=Bowton+D.L.&coden=CCHMD&isbn=&pages=701-710&date=2016&auinit1=D&auinitm=L
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 234
TITLE
  Intraoperative neck positioning for maxillofacial procedures on patients 
with cervical spine injuries, is it safe to remove the collar?
AUTHOR NAMES
  Schilling C.; Spiers H.; Hayes E.; Jones T.L.; Manisali M.
AUTHOR ADDRESSES
  (Schilling C.; Spiers H.; Hayes E.; Jones T.L.; Manisali M.) Guys Hospital 
and St Georges Hospital, London, United Kingdom.
CORRESPONDENCE ADDRESS
  C. Schilling, Guys Hospital and St Georges Hospital, London, United Kingdom.
FULL RECORD ENTRY DATE
  2017-01-03
SOURCE
  British Journal of Oral and Maxillofacial Surgery (2016) 54:10 (e163-e164). 
Date of Publication: 1 Dec 2016
VOLUME
  54
ISSUE
  10
FIRST PAGE
  e163
LAST PAGE
  e164
DATE OF PUBLICATION
  1 Dec 2016
CONFERENCE NAME
  Annual Scientific Meeting of the British Association of Oral and 
Maxillofacial Surgery 2016
CONFERENCE LOCATION
  Brighton, United Kingdom
CONFERENCE DATE
  2016-06-08 to 2016-06-10
ISSN
  1532-1940
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  Introduction: Concomitant cervical spine and maxillofacial injury is 
reported in 2.2-11% of trauma patients. High-risk c-spine injuries not 
requiring immediate fixation are immobilised in a semi-rigid collar support, 
interfering with assessment and timely treatment of maxillofacial injuries. 
This can lead to extensive (delayed) maxillofacial surgery once healing has 
occurred. We present (for the first time) magnetic resonance images (MRI) 
demonstrating the alignment of the cervical spine during common 
maxillofacial procedures in order to assist spinal surgeons in deciding 
whether it is safe to undertake surgery without collar support.Methods: 
T(2)-weighted axial and sagittal MRI of the c-spine was acquired in a 
healthy volunteer and reviewed by a spinal surgeon. The following 
intraoperative neck positions were simulated using a head ring +/- shoulder 
bolster for (i) central midface/mandible fixation (neutral), (ii) surgical 
tracheostomy (extension), (iii) mandibular condyle fixation (lateral 
rotation).Results: Neutral position displays minimal effect on normal 
c-spine alignment (mouth open or closed). Positions (ii) and (iii) show 
changes in alignment providing invaluable information for the spinal surgeon 
to decide if the fracture pattern is stable enough to allow positioning in 
(ii) flexion/extension or (iii) in rotation.Conclusion: Our results have 
shown that maxillofacial surgery where the neck is held in a neutral 
position (e.g. ORIF anterior mandible) is highly unlikely to cause further 
damage in most patients. For other procedures risk is dependent upon the 
injury pattern. These results are the first step in producing at guideline 
to aid inter-specialty decision making in the multiply injured patient.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; clinical study; 
EMTREE MEDICAL INDEX TERMS
  controlled study; decision making; doctor patient relationship; face; fracture; human; mandible condyle; maxillofacial injury; maxillofacial surgery; mouth; nuclear magnetic resonance; practice guideline; rigid collar; rotation; shoulder; surgeon; surgery; tracheostomy; volunteer; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L613917962
DOI
  10.1016/j.bjoms.2016.11.273
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.bjoms.2016.11.273
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15321940&id=doi:10.1016%2Fj.bjoms.2016.11.273&atitle=Intraoperative+neck+positioning+for+maxillofacial+procedures+on+patients+with+cervical+spine+injuries%2C+is+it+safe+to+remove+the+collar%3F&stitle=Br.+J.+Oral+Maxillofac.+Surg.&title=British+Journal+of+Oral+and+Maxillofacial+Surgery&volume=54&issue=10&spage=e163&epage=e164&aulast=Schilling&aufirst=Clare&auinit=C.&aufull=Schilling+C.&coden=&isbn=&pages=e163-e164&date=2016&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 235
TITLE
  Complete Tracheal Resection in Closed Cervical Spine Injury
ORIGINAL (NON-ENGLISH) TITLE
  Sección traqueal completa por traumatismo cervical cerrado
AUTHOR NAMES
  Rodríguez Gómez C.M.; Rubio Garay M.; Baldó Padró X.
AUTHOR ADDRESSES
  (Rodríguez Gómez C.M., mia_2612@hotmail.com; Rubio Garay M.; Baldó Padró X.) 
Servicio de Cirugía Torácica, Hospital Josep Trueta, Girona, Spain.
CORRESPONDENCE ADDRESS
  C.M. Rodríguez Gómez, Servicio de Cirugía Torácica, Hospital Josep Trueta, 
Girona, Spain. Email: mia_2612@hotmail.com
AiP/IP ENTRY DATE
  2018-04-09
FULL RECORD ENTRY DATE
  2018-04-20
SOURCE
  Archivos de Bronconeumologia (2016) 52:12 (614). Date of Publication: 1 Dec 
2016
VOLUME
  52
ISSUE
  12
FIRST PAGE
  614
DATE OF PUBLICATION
  1 Dec 2016
ISSN
  1579-2129 (electronic)
  0300-2896
BOOK PUBLISHER
  Elsevier Doyma
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (surgery); trachea resection; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; case report; clinical article; computer assisted tomography; dysphonia; emergency surgery; endotracheal intubation; endotracheal tube; extubation; hemodynamics; human; male; tracheostomy tube; tracheotomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English, Spanish
EMBASE ACCESSION NUMBER
  20180243872
PUI
  L2000572975
DOI
  10.1016/j.arbr.2016.01.022
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.arbr.2016.01.022
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15792129&id=doi:10.1016%2Fj.arbr.2016.01.022&atitle=Complete+Tracheal+Resection+in+Closed+Cervical+Spine+Injury&stitle=Arch.+Bronconeumol.&title=Archivos+de+Bronconeumologia&volume=52&issue=12&spage=614&epage=&aulast=Rodr%C3%ADguez+G%C3%B3mez&aufirst=Carmen+Mar%C3%ADa&auinit=C.M.&aufull=Rodr%C3%ADguez+G%C3%B3mez+C.M.&coden=ARBRD&isbn=&pages=614-&date=2016&auinit1=C&auinitm=M
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 236
TITLE
  Long-Term Mechanical Ventilation
AUTHOR NAMES
  Sahetya S.; Allgood S.; Gay P.C.; Lechtzin N.
AUTHOR ADDRESSES
  (Sahetya S.; Allgood S.; Lechtzin N.) Division of Pulmonary, Critical Care 
and Sleep Medicine, Department of Medicine, Johns Hopkins University School 
of Medicine, Baltimore, United States.
(Gay P.C., pgay@mayo.edu) Pulmonary and Critical Care, The Mayo Clinic, 200 
First Street Southwest, Rochester, United States.
CORRESPONDENCE ADDRESS
  P.C. Gay, Pulmonary and Critical Care, The Mayo Clinic, 200 First Street 
Southwest, Rochester, United States. Email: pgay@mayo.edu
AiP/IP ENTRY DATE
  2016-10-20
FULL RECORD ENTRY DATE
  2016-12-14
SOURCE
  Clinics in Chest Medicine (2016) 37:4 (753-763). Date of Publication: 1 Dec 
2016
VOLUME
  37
ISSUE
  4
FIRST PAGE
  753
LAST PAGE
  763
DATE OF PUBLICATION
  1 Dec 2016
ISSN
  1557-8216 (electronic)
  0272-5231
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Although precise numbers are difficult to obtain, the population of patients 
receiving long-term ventilation has increased over the last 20 years, and 
includes patients with chronic lung diseases, neuromuscular diseases, spinal 
cord injury, and children with complex disorders. This article reviews the 
equipment and logistics involved with ventilation outside of the hospital. 
Discussed are common locations for long-term ventilation, airway and 
secretion management, and many of the potential challenges faced by 
individuals on long-term ventilation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; patient care; practice guideline; 
EMTREE MEDICAL INDEX TERMS
  acute lung injury; adult respiratory distress syndrome; amyotrophic lateral sclerosis; chronic obstructive lung disease; cohort analysis; depression; deterioration; disease exacerbation; fibrosing alveolitis; health care facility; health service; hospital discharge; hospitalization; human; hypercapnia; hypoventilation; hypoxemia; intensive care unit; interstitial lung disease; mechanical exsufflator; mechanical insufflator; mechanical ventilator; noninvasive ventilation; patient autonomy; priority journal; quality of life; reimbursement; resuscitation; review; spinal cord injury; stress; terminal care; thorax deformity; tracheostomy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160744246
MEDLINE PMID
  27842754 (http://www.ncbi.nlm.nih.gov/pubmed/27842754)
PUI
  L612774378
DOI
  10.1016/j.ccm.2016.07.014
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ccm.2016.07.014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15578216&id=doi:10.1016%2Fj.ccm.2016.07.014&atitle=Long-Term+Mechanical+Ventilation&stitle=Clin.+Chest+Med.&title=Clinics+in+Chest+Medicine&volume=37&issue=4&spage=753&epage=763&aulast=Sahetya&aufirst=Sarina&auinit=S.&aufull=Sahetya+S.&coden=CCHMD&isbn=&pages=753-763&date=2016&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 237
TITLE
  Vertebral Artery Occlusion and Recanalization After Cervical Facet 
Dislocation
AUTHOR NAMES
  Zhang Z.; Wang H.; Mu Z.
AUTHOR ADDRESSES
  (Zhang Z., zhangz3@126.com; Wang H.; Mu Z.) Department of Orthopedics, 
Xinqiao Hospital, Third Military Medical University, Chongqing, China.
CORRESPONDENCE ADDRESS
  Z. Zhang, Email: zhangz3@126.com
AiP/IP ENTRY DATE
  2016-09-26
FULL RECORD ENTRY DATE
  2016-09-30
SOURCE
  World Neurosurgery (2016) 95 (2-5). Date of Publication: 1 Nov 2016
VOLUME
  95
FIRST PAGE
  2
LAST PAGE
  5
DATE OF PUBLICATION
  1 Nov 2016
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Objective To investigate clinical features of vertebral artery (VA) 
occlusion and recanalization after cervical facet dislocation. Methods 
During a 2-year period from January 2014 to December 2015, 29 consecutive 
patients with cervical facet dislocation were treated in investigator group. 
VA occlusion and recanalization were identified retrospectively by magnetic 
resonance imaging (MRI) at the time of injury and follow-up. Results VA 
occlusion occurred in 6 of the 29 patients (20.7%). All patients were 
unilateral occlusion and had no vertebrobasilar symptoms. Surgical anterior 
spinal fusion was performed in 5 patients, and 1 was treated by posterior 
fusion. Follow-up MRIs revealed VA recanalization in 5 patients. One patient 
did not undergo MRI because he died of respiratory failure. The time course 
for VA recanalization was from 6 days after injury to 4 months after 
operation depending on the length of VA occlusion. Conclusions A fifth of 
patients with cervical facet dislocation will develop VA occlusion with rare 
symptomatic vertebrobasilar ischemia. VA recanalization occurs mainly within 
the first 4 months after injury, regardless of the length of VA occlusion.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical facet dislocation (surgery); cervical spine dislocation (surgery); recanalization; vertebral artery stenosis (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; anterior spine fusion; article; clinical article; clinical feature; clinical trial; female; follow up; human; male; middle aged; nuclear magnetic resonance imaging; respiratory failure; retrospective study; spinal cord injury; thorax injury (surgery); tracheostomy; vertebral arteriography; vertebrobasilar insufficiency; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160675956
MEDLINE PMID
  27535628 (http://www.ncbi.nlm.nih.gov/pubmed/27535628)
PUI
  L612208667
DOI
  10.1016/j.wneu.2016.08.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2016.08.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2016.08.002&atitle=Vertebral+Artery+Occlusion+and+Recanalization+After+Cervical+Facet+Dislocation&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=95&issue=&spage=2&epage=5&aulast=Zhang&aufirst=Zhengfeng&auinit=Z.&aufull=Zhang+Z.&coden=&isbn=&pages=2-5&date=2016&auinit1=Z&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 238
TITLE
  Protein-losing enteropathy with intestinal lymphangiectasia in skeletal 
dysplasia with Lys650Met mutation
AUTHOR NAMES
  Yang C.; Dehner L.P.
AUTHOR ADDRESSES
  (Yang C.; Dehner L.P., dehner@path.wustl.edu) Division of Anatomic and 
Molecular Pathology, Department of Pathology and Immunology, St. Louis 
Children's Hospital, Washington University Medical Center, St. Louis, United 
States.
CORRESPONDENCE ADDRESS
  L.P. Dehner, Division of Anatomic and Molecular Pathology, Department of 
Pathology and Immunology, St. Louis Children's Hospital, Washington 
University Medical Center, St. Louis, United States. Email: 
dehner@path.wustl.edu
AiP/IP ENTRY DATE
  2016-06-06
FULL RECORD ENTRY DATE
  2016-11-07
SOURCE
  American Journal of Medical Genetics, Part A (2016) 170:11 (2993-2997). Date 
of Publication: 1 Nov 2016
VOLUME
  170
ISSUE
  11
FIRST PAGE
  2993
LAST PAGE
  2997
DATE OF PUBLICATION
  1 Nov 2016
ISSN
  1552-4833 (electronic)
  1552-4825
BOOK PUBLISHER
  Wiley-Liss Inc., info@wiley.com
ABSTRACT
  Protein-losing enteropathy is a primary or secondary manifestation of a 
group of conditions, and etiologies which are broadly divisible into those 
with mucosal injury on the basis of inflammatory and ulcerative conditions, 
mucosal injury without erosions or ulcerations, and lymphatic abnormalities. 
We describe the first case of protein-losing enteropathy in a pediatric 
patient, with severe skeletal dysplasia consistent with thanatophoric 
dysplasia type I and DNA analysis that revealed a c.1949A>T (p.Lys650Met) in 
exon 15 of the FGFR3 gene. She presented with protein-losing enteropathy in 
her 6th month. Post-mortem examination revealed lymphangiectasia in the 
small intestine. To our knowledge, this is the first report of intestinal 
lymphangiectasia as a complication of skeletal dysplasia resulting in severe 
protein-losing enteropathy. © 2016 Wiley Periodicals, Inc.
EMTREE DRUG INDEX TERMS
  alpha 1 antitrypsin (endogenous compound); fibroblast growth factor receptor 3 (endogenous compound); immunoglobulin (intravenous drug administration); immunoglobulin G (endogenous compound); sildenafil (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone dysplasia (diagnosis); gene mutation; intestine lymphangiectasia (complication, diagnosis); protein losing gastroenteropathy (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  acanthosis nigricans (diagnosis); achondroplasia (diagnosis); article; assisted ventilation; bone radiography; bradycardia; case report; disease course; disease severity; DNA determination; exon; feces level; female; FGFR3 gene; foramen magnum; human; hypercapnia (therapy); hypoalbuminemia; immunoglobulin blood level; infant; lymphocytopenia; neonatal respiratory distress syndrome (surgery, therapy); nuclear magnetic resonance imaging; oxygen desaturation; priority journal; pulmonary hypertension (complication, drug therapy); skeleton malformation (diagnosis); spinal cord compression; thanatophoric dwarfism (diagnosis); total parenteral nutrition; tracheostomy; 
CAS REGISTRY NUMBERS
  alpha 1 antitrypsin (9041-92-3)
  fibroblast growth factor receptor 3 (306781-00-0)
  immunoglobulin (9007-83-4)
  immunoglobulin G (97794-27-9)
  sildenafil (139755-83-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160405085
MEDLINE PMID
  27214123 (http://www.ncbi.nlm.nih.gov/pubmed/27214123)
PUI
  L610555318
DOI
  10.1002/ajmg.a.37756
FULL TEXT LINK
  http://dx.doi.org/10.1002/ajmg.a.37756
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15524833&id=doi:10.1002%2Fajmg.a.37756&atitle=Protein-losing+enteropathy+with+intestinal+lymphangiectasia+in+skeletal+dysplasia+with+Lys650Met+mutation&stitle=Am.+J.+Med.+Genet.+Part+A&title=American+Journal+of+Medical+Genetics%2C+Part+A&volume=170&issue=11&spage=2993&epage=2997&aulast=Yang&aufirst=Chen&auinit=C.&aufull=Yang+C.&coden=AJMGD&isbn=&pages=2993-2997&date=2016&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 239
TITLE
  Surgical Treatment of Occipitocervical Dislocation with Atlas Assimilation 
and Klippel-Feil Syndrome Using Occipitalized C1 Lateral Mass and C2 
Fixation and Reduction Technique
AUTHOR NAMES
  Yin Y.-H.; Qiao G.-Y.; Yu X.-G.
AUTHOR ADDRESSES
  (Yin Y.-H.; Qiao G.-Y., neuroplahp@126.com; Yu X.-G., xg_yu@aliyun.com) 
Department of Neurosurgery, PLA General Hospital, Beijing, China.
CORRESPONDENCE ADDRESS
  G.-Y. Qiao, Guang-Yu Qiao, M.D.; Xin-Guang Yu, M.D., Ph.D., China. Email: 
neuroplahp@126.com
AiP/IP ENTRY DATE
  2016-09-02
FULL RECORD ENTRY DATE
  2016-09-13
SOURCE
  World Neurosurgery (2016) 95 (46-52). Date of Publication: 1 Nov 2016
VOLUME
  95
FIRST PAGE
  46
LAST PAGE
  52
DATE OF PUBLICATION
  1 Nov 2016
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Objective To introduce and assess a surgical treatment of occipitocervical 
(OC) dislocation with atlas assimilation and Klippel-Feil syndrome (KFS) 
using occipitalized C1 lateral mass and C2 fixation and reduction technique. 
Methods From January 2007 to August 2013, 58 symptomatic patients with OC 
dislocation and KFS of C2-3 congenital fusion and atlas assimilation were 
surgically treated in our institution via this technique. After opening the 
C1-2 facet joints via a posterior approach, OC reduction was conducted by 
intraoperative manipulation and C1 lateral mass and C2 pedicle screw and rod 
fixation. The instrument position, fusion status, and clinical outcome were 
analyzed. Results The average follow-up was 36 months (range, 18–52 months). 
Radiologically, effective reduction was achieved in 56 patients (96.6%) and 
<50% reduction in 2 (3.4%) who had additional transoral decompression. 
Neurologic improvement and solid bone fusion were achieved in all patients. 
The clinical symptoms improved for all patients, with the averaged Japanese 
Orthopedic Association myelopathy scores increasing from 11.5 to 15.6 (P < 
0.01). Conclusions In patients with OC dislocation and KFS of C2-3 fusion 
and atlas assimilation, posterior manipulative reduction combined with 
occipitalized C1 lateral mass and C2 fixation provides a reliable and 
effective treatment.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); anticoagulant agent (drug therapy); fibrinolytic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fracture fixation; fracture reduction; Klippel Feil syndrome (surgery); occipitocervical dislocation (surgery); skull injury (surgery); vertebra dislocation (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; antibiotic therapy; anticoagulant therapy; artery injury (complication); article; cervical collar; cervical spine radiography; clinical effectiveness; clinical outcome; computer assisted tomography; coughing (complication); cranial drill; deep vein thrombosis (complication, drug therapy); dyspnea (complication, surgery, therapy); feasibility study; female; fibrinolytic therapy; first cervical vertebra; follow up; human; interlaminal fixation device (adverse device effect); intramedullary nailing; Japanese Orthopedic Association Cervical Myelopathy Evaluation; lung infection (complication, drug therapy); major clinical study; male; middle aged; neuroimaging; nuclear magnetic resonance imaging; pedicle screw fixation device (adverse device effect); pneumonia (complication, drug therapy); postoperative infection (complication, drug therapy); retrospective study; second cervical vertebra; spinal cord decompression; spinal cord injury (complication); spinal cord vascular disease (complication); spine fusion; spine manipulation; surgical patient; third cervical vertebra; tracheotomy; ventilator; vertebral artery injury (complication); 
DEVICE TRADE NAMES
  Vertex  , United StatesMedtronic Sofamor Danek

DEVICE MANUFACTURERS
   (China)libeier bioengineering institute
   (United States)Medtronic Sofamor Danek
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160625619
MEDLINE PMID
  27465418 (http://www.ncbi.nlm.nih.gov/pubmed/27465418)
PUI
  L611855684
DOI
  10.1016/j.wneu.2016.07.058
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2016.07.058
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2016.07.058&atitle=Surgical+Treatment+of+Occipitocervical+Dislocation+with+Atlas+Assimilation+and+Klippel-Feil+Syndrome+Using+Occipitalized+C1+Lateral+Mass+and+C2+Fixation+and+Reduction+Technique&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=95&issue=&spage=46&epage=52&aulast=Yin&aufirst=Yi-Heng&auinit=Y.-H.&aufull=Yin+Y.-H.&coden=&isbn=&pages=46-52&date=2016&auinit1=Y&auinitm=-H
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 240
TITLE
  Successful tracheostomy decannulation after motor complete cervical spinal 
cord injury
AUTHOR NAMES
  Kim D.H.; Kang S.-W.; Choi W.-A.; Suh M.-R.
AUTHOR ADDRESSES
  (Kim D.H.; Kang S.-W.; Choi W.-A.; Suh M.-R.) Kangdong Sacred Heart 
Hospital, Hallym University, College of Medicine, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  D.H. Kim, Kangdong Sacred Heart Hospital, Hallym University, College of 
Medicine, Seoul, South Korea.
FULL RECORD ENTRY DATE
  2016-12-05
SOURCE
  Chest (2016) 150:4 Supplement 1 (1122A). Date of Publication: 1 Oct 2016
VOLUME
  150
ISSUE
  4
FIRST PAGE
  1122A
DATE OF PUBLICATION
  1 Oct 2016
CONFERENCE NAME
  CHEST 2016
CONFERENCE LOCATION
  Los Angeles, CA, United States
CONFERENCE DATE
  2016-10-22 to 2016-10-26
ISSN
  1931-3543
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  PURPOSE: Respiratory dysfunction is a major cause of morbidity and mortality 
in spinal cord injury (SCI), which causes impairment of respiratory muscles, 
reduced vital capacity, inefficient cough, and impaired mechanics of 
ventilation. Patients with cervical SCI (CSCI) are at increased risk of 
tracheostomy although the majority can be managed noninvasively without 
empiric tracheostomy. We aimed to analyze the successful tracheostomy 
decannulation or extubation in motor complete CSCI patients. METHODS: Motor 
complete CSCI patients who had received invasive acute phase respiratory 
management, and succeeded in either decannulation or extubation at pulmonary 
rehabilitation center of Gangnam Severance hospital became candidates of 
this study. Retrospective review was conducted on the transitions of the 
respiratory status. RESULTS: Sixty-two motor complete CSCI patients (M:55, 
F:7) were identified. Traumatic causes of SCI accounted for 93.5% (n=58), 
and mean age at SCI onset was 47.6 ± 15.8 yrs. Sixty patients (96.8%) had 
undergone tracheostomy and the other 2 received endotracheal intubation 
during acute phase management. All patients succeeded in 
decannulation/extubation after employing mechanically assisted coughing 
(MAC) and noninvasive mechanical ventilation (NIV). Mean time since 
tracheostomy to decannulation was 7.0 ± 14.5 months. Of the 60 
tracheostomized patients, 12 succeeded in decannulation without applying 
long-term NIV, 31 switched to continuous NIV after decannulation. Fifteen 
patients totally weaned off from ventilators after NIV. Two patients who 
once succeeded in decannulation was re-tracheostomized due to unexpected 
emergencies. For the 31 patients with continuous NIV, mean hours of daily 
need for ventilatory support had reduced from initial 15.3 ± 8.0 hrs to 5.7 
± 5.7 hrs at final follow ups. CONCLUSIONS: Motor complete CSCI patients 
even with high neurologic level of injury can benefit from NIV and 
aggressive use of MAC. Undesirable tracheostomy can be avoided by employing 
the noninvasive respiratory management.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; coughing; endotracheal intubation; extubation; hospital; human; major clinical study; middle aged; nervous system; pulmonary rehabilitation; retrospective study; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L613468458
DOI
  10.1016/j.chest.2016.08.1231
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.chest.2016.08.1231
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19313543&id=doi:10.1016%2Fj.chest.2016.08.1231&atitle=Successful+tracheostomy+decannulation+after+motor+complete+cervical+spinal+cord+injury&stitle=Chest&title=Chest&volume=150&issue=4&spage=1122A&epage=&aulast=Kim&aufirst=Dong+Hyun&auinit=D.H.&aufull=Kim+D.H.&coden=&isbn=&pages=1122A-&date=2016&auinit1=D&auinitm=H
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 241
TITLE
  Bradycardia and cardiac arrest during tracheal suction in a patient with 
traumatic spinal cord injury
AUTHOR NAMES
  Shimamoto S.; Saito N.; Suzuki H.; Akiduki N.; Namiki M.; Takeda M.; Yaguchi A.
AUTHOR ADDRESSES
  (Shimamoto S.; Saito N.; Suzuki H.; Akiduki N.; Namiki M.; Takeda M.; 
Yaguchi A.) Department of Critical Care and Emergency Medicine, Tokyo 
Women's Medical University, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  S. Shimamoto, Department of Critical Care and Emergency Medicine, Tokyo 
Women's Medical University, Tokyo, Japan.
FULL RECORD ENTRY DATE
  2016-11-10
SOURCE
  Shock (2016) 46:4 Supplement 2 (51). Date of Publication: 1 Oct 2016
VOLUME
  46
ISSUE
  4
FIRST PAGE
  51
DATE OF PUBLICATION
  1 Oct 2016
CONFERENCE NAME
  8th Congress of the International Federation of Shock Societies
CONFERENCE LOCATION
  Tokyo, Japan
CONFERENCE DATE
  2016-10-03 to 2016-10-05
ISSN
  1540-0514
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Spinal shock is a common complication in patients with acute spinal cord 
injury. It involves a transient loss of spinal reflexes for approximately 48 
h after the injury. Neurogenic shock is another possible complication, 
particularly in patients with high complete cervical spinal cord injuries; 
this usually diminishes within the first 2-6 weeks after the injury, but 
occurs during the chronic phase. We present the case of a tetraplegic 
patient who developed cardiac arrest following bradycardia during tracheal 
suction in the ICU 6 weeks after the injury. A 72-year-old male fell down 
the stairs and was transferred to the emergency department with tetraplegia. 
He was admitted to the intensive care unit with a diagnosis of complete 
cervical spinal cord injury at C4 and C5. He required mechanical 
ventilation. A tracheostomy was performed at 14 days, and laminectomy and 
laminoplasty were performed 24 days after the injury for the dislocation 
fracture of the cervical vertebrae. Mechanical ventilatory support was still 
required. Forty-two days after the injury, bradycardia during tracheal 
suction was accompanied by a decline in SpO2, and cardiac arrest occurred. 
After 4 min of resuscitation and administration of 1 mg adrenaline, the 
patient recovered without complications. Although cardiac pacemaker and 
administration of atropine or aminophylline were considered for preventing 
further occurrences of bradycardia and cardiac arrest, providing high 
oxygenation before tracheal suction and shortening the duration of tracheal 
suction prevented those adverse events. This complication did not occur 
again in the clinical course of this patient. There are some reports on 
cardiopulmonary complications following spinal cord injury regardless of 
spinal shock. These complications are associated with more severe spinal 
cord injuries and those at higher levels. In particular, tracheal stimuli 
such as suction, intubation, and bronchoscopy seem to induce bradycardia and 
even asystole in the presence of hypoxia due to the vasovagal reflex. In 
normal conditions, this reflex is controlled by sympathetic activity due to 
increased breathing; however, this compensatory sympathetic activity is 
inhibited by cervical cord lesions and does not function in patients with 
cervical spinal injury. The patient in this case has not had any 
complication since the cardiac arrest and does not require additional 
therapy; however, some patients die because of this complication and some 
require a cardiac pacemaker or maintenance treatment with atropine. Cardiac 
dysfunctions are usually life-threatening complications which occur during 
the non-acute phase in patients with severe cervical spinal cord injury.
EMTREE DRUG INDEX TERMS
  aminophylline; atropine; epinephrine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bradycardia; cervical spinal cord injury; heart arrest; suction; trachea; 
EMTREE MEDICAL INDEX TERMS
  adverse drug reaction; aged; artificial ventilation; bronchoscopy; case report; cervical vertebra; clinical trial; complication; diagnosis; disease duration; emergency ward; fracture dislocation; human; hypoxia; intensive care unit; intubation; laminectomy; laminoplasty; maintenance therapy; male; oxygenation; prevention; quadriplegia; reflex; resuscitation; side effect; sinus node; stimulus; sympathetic tone; tracheostomy; 
CAS REGISTRY NUMBERS
  aminophylline (317-34-0)
  atropine (51-55-8, 55-48-1)
  epinephrine (51-43-4, 55-31-2, 6912-68-1)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L612897107
DOI
  10.1097/SHK.0000000000000706
FULL TEXT LINK
  http://dx.doi.org/10.1097/SHK.0000000000000706
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15400514&id=doi:10.1097%2FSHK.0000000000000706&atitle=Bradycardia+and+cardiac+arrest+during+tracheal+suction+in+a+patient+with+traumatic+spinal+cord+injury&stitle=Shock&title=Shock&volume=46&issue=4&spage=51&epage=&aulast=Shimamoto&aufirst=Shuji&auinit=S.&aufull=Shimamoto+S.&coden=&isbn=&pages=51-&date=2016&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 242
TITLE
  The long-term outcome of early spine fusion for scoliosis in children with 
cerebral palsy
AUTHOR NAMES
  Sitoula P.; Holmes L.; Sees J.; Rogers K.; Dabney K.; Miller F.
AUTHOR ADDRESSES
  (Sitoula P.; Holmes L.; Sees J.; Rogers K.; Dabney K.; Miller F., 
fmiller@nemours.org) Department of Orthopedics, Nemours/ Alfred I. duPont 
Hospital for Children, PO Box 269, Wilmington, United States.
CORRESPONDENCE ADDRESS
  F. Miller, Department of Orthopedics, Nemours/ Alfred I. duPont Hospital for 
Children, PO Box 269, Wilmington, United States. Email: fmiller@nemours.org
AiP/IP ENTRY DATE
  2016-10-28
FULL RECORD ENTRY DATE
  2016-11-14
SOURCE
  Clinical Spine Surgery (2016) 29:8 (E406-E412). Date of Publication: 1 Oct 
2016
VOLUME
  29
ISSUE
  8
FIRST PAGE
  E406
LAST PAGE
  E412
DATE OF PUBLICATION
  1 Oct 2016
ISSN
  2380-0194 (electronic)
  2380-0186
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study Design: Retrospective review of radiographs and charts (case-only). 
Objective: The aim of this study was to describe the long-term outcomes of 
spine fusion for neuromuscular scoliosis in children below 10 years of age 
with cerebral palsy (CP). Summary of Background Data: Severely involved 
children with CP may develop early-onset scoliosis. The outcome of spine 
fusion is not clear and there are no studies focused on spine fusion in this 
young patient population. Methods: This is a retrospective review of 33 
children who underwent spine fusion with unit-rod instrumentation between 
1989 and 2006 for CP neuromuscular scoliosis, aged below 10 years at spine 
fusion, and with follow-up >5 years. Demographic, medical, and radiographic 
data were retrospectively assessed. Repeated measure analysis of variance 
and Kaplan-Meier survival estimates were used for data assessment. Results: 
Thirty-three of 42 patients who underwent spine fusion in this period, 19 
boys and 14 girls, met the inclusion criteria. Of 9 patients who were 
excluded, 3 were lost to follow-up and remaining 6 died within 5 years of 
surgery. Mean age at surgery was 8.3 years (range, 4.4-9.9 y). Mean 
follow-up was 9.8 years (range, 5.5-15.8 y). Gross motor function 
classification system level was V in 31 patients and IV in 2 patients. 
Thirty-one patients (94%) had seizure disorder, 29 patients (88%) had 
gastric feeding tubes, and 9 patients (27%) had tracheostomy tubes. 
Eighty-five percent of the patients had posterior-only surgery. Mean Cobb 
angles preoperative, immediately postoperative, and at final follow-up were 
85, 21, and 24 degrees, respectively. Mean postoperative pelvic obliquity 
correction was 15±9 degrees (P<0.001). At final follow-up, there was no 
significant change from the postoperative measurements. Complications 
included 1 deep wound infection and 10 other problems. Eleven patients 
(28.2%) died after a mean follow-up of 5.6±3.8 years. Conclusions: In our 
cohort with early-onset neuromuscular scoliosis, spine fusion was associated 
with minimal short-term and long-term morbidity, but there was 28% mortality 
at 10 years of follow-up and 50% predicted mortality at 15 years.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cerebral palsy; scoliosis (surgery); spine fusion; treatment outcome; 
EMTREE MEDICAL INDEX TERMS
  child; clinical article; Cobb angle; comorbidity; female; human; male; mortality; motor performance; outcome assessment; postoperative complication (complication); retrospective study; review; spine radiography; surgical technique; treatment indication; wound infection (complication); 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160769074
MEDLINE PMID
  25310392 (http://www.ncbi.nlm.nih.gov/pubmed/25310392)
PUI
  L612914763
DOI
  10.1097/BSD.0000000000000184
FULL TEXT LINK
  http://dx.doi.org/10.1097/BSD.0000000000000184
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23800194&id=doi:10.1097%2FBSD.0000000000000184&atitle=The+long-term+outcome+of+early+spine+fusion+for+scoliosis+in+children+with+cerebral+palsy&stitle=Clin.+Spine+Surg.&title=Clinical+Spine+Surgery&volume=29&issue=8&spage=E406&epage=E412&aulast=Sitoula&aufirst=Prakash&auinit=P.&aufull=Sitoula+P.&coden=&isbn=&pages=E406-E412&date=2016&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 243
TITLE
  Air in the brain seven years after cervical spine surgery
AUTHOR NAMES
  Bugov D.; Raoof N.; Pastores S.; Halpern N.
AUTHOR ADDRESSES
  (Bugov D.; Raoof N.; Pastores S.; Halpern N.) Memorial Sloan Kettering 
Cancer Center, New York, United States.
CORRESPONDENCE ADDRESS
  N. Raoof, Memorial Sloan Kettering Cancer Center, New York, United States.
FULL RECORD ENTRY DATE
  2016-12-05
SOURCE
  Chest (2016) 150:4 Supplement 1 (236A). Date of Publication: 1 Oct 2016
VOLUME
  150
ISSUE
  4
FIRST PAGE
  236A
DATE OF PUBLICATION
  1 Oct 2016
CONFERENCE NAME
  CHEST 2016
CONFERENCE LOCATION
  Los Angeles, CA, United States
CONFERENCE DATE
  2016-10-22 to 2016-10-26
ISSN
  1931-3543
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  INTRODUCTION: Medical patients presenting with new or recurrent seizures 
often have a workup that focuses exclusively on infectious and inflammatory 
etiologies. However, it is vital to consider the patient's surgical history, 
however remote. CASE PRESENTATION: The patient is a 52-year old man with 
childhood seizure disorder well controlled on single agent therapy and C2 
chondrosarcoma for which he underwent transmandibular resection with 
reconstruction and posterior occipitocervical fusion in 2007 followed by 
adjuvant radiation. Seven years later, he was treated for E. coli sepsis and 
recurrent infections after dental extractions. Soon after, he developed 
severe dysphagia and was readmitted with aspiration pneumonia and 
Peptostreptococcus sepsis. He was supported with noninvasive ventilation 
(NIV) until he developed seizures and required intubation which was 
difficult due to anatomy (only pharyngeal exudate was noted). 
Transesophageal echocardiography was unsuccessful due to a pharyngeal mass. 
Seizure workup included CT head (pneumocephalus attributed to earlier 
attempts at nasogastric tube placement) and CSF analysis (leukocytosis 
only). Extubation was deemed high risk given upper airway anatomy and he 
underwent PEG and tracheostomy. Endoscopy revealed perforation of the 
cervical hardware through the posterior pharynx. He was transferred to our 
institution where his posterior pharyngeal defect was repaired with a 
myocutaneous flap. He remained hospitalized for four weeks with recurrent 
pneumonia and poor pulmonary toilet. He was ultimately discharged to a 
subacute rehabilitation facility. DISCUSSION: While pneumocephalus has been 
described with noninvasive ventilation, this is often in the setting of 
neurosurgery or trauma. In this case, it was related to a delayed 
complication of spinal surgery. The patient had poorly explained 
pneumocephalus and numerous indicators that there may have been a problem in 
the pharynx (aspiration, difficult intubation and unsuccessful TEE). However 
a definitive pharyngeal exam was not performed until endoscopy two weeks 
after presentation. CONCLUSIONS: Patients with previous cervical spine 
surgery, even remote, may be at risk for pneumocephalus after NIV. This risk 
is increased if they are chronically ill and at risk for pharyngeal mucosal 
breakdown.
EMTREE DRUG INDEX TERMS
  adjuvant; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; anatomy; aspiration pneumonia; case report; childhood; chondrosarcoma; chronic patient; computer; dysphagia; endoscopy; extubation; exudate; female; head; human; leukocytosis; male; middle aged; myocutaneous flap; nasogastric tube; neurosurgery; noninvasive ventilation; perforation; pharynx; pneumocephalus; pneumonia; radiation; recurrent infection; rehabilitation; seizure; sepsis; tooth extraction; tracheostomy; transesophageal echocardiography; upper respiratory tract; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L613468730
DOI
  10.1016/j.chest.2016.08.249
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.chest.2016.08.249
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19313543&id=doi:10.1016%2Fj.chest.2016.08.249&atitle=Air+in+the+brain+seven+years+after+cervical+spine+surgery&stitle=Chest&title=Chest&volume=150&issue=4&spage=236A&epage=&aulast=Bugov&aufirst=Dona&auinit=D.&aufull=Bugov+D.&coden=&isbn=&pages=236A-&date=2016&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 244
TITLE
  Cough augmentation techniques in the critically ill: A canadian national 
survey
AUTHOR NAMES
  Rose L.; Adhikari N.K.; Poon J.; Leasa D.; McKim D.A.
AUTHOR ADDRESSES
  (Rose L., louise.rose@utoronto.ca; Adhikari N.K.; Poon J.) Sunnybrook Health 
Sciences Centre, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.; Poon J.) Lawrence S 
Bloomberg Faculty of Nursing, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.; Poon J.) University of 
Toronto, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.; Poon J.) Provincial Centre 
of Weaning Excellence/Prolonged Ventilation Weaning Centre, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.; Poon J.) Toronto East 
General Hospital, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.; Poon J.) Mount Sinai 
Hospital, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, 
Canada.
(Adhikari N.K.) Sunnybrook Health Sciences Centre, Interdivisional 
Department of Critical Care, University of Toronto, Toronto, Canada.
(Poon J.) Faculty of Medicine, University of Sydney, Sydney, Australia.
(Leasa D.) Critical Care Western and London Health Sciences Centre and 
Western University, London, Canada.
(McKim D.A.) Ottawa Hospital Respiratory Rehabilitation Center, The Ottawa 
Hospital Sleep Centre, The University of Ottawa, Ottawa, Canada.
CORRESPONDENCE ADDRESS
  L. Rose, Lawrence S Bloomberg Faculty of Nursing, University of Toronto, 155 
College Street, Room, 276, Toronto, Canada. Email: louise.rose@utoronto.ca
AiP/IP ENTRY DATE
  2016-10-06
FULL RECORD ENTRY DATE
  2016-10-12
SOURCE
  Respiratory Care (2016) 61:10 (1360-1368). Date of Publication: 1 Oct 2016
VOLUME
  61
ISSUE
  10
FIRST PAGE
  1360
LAST PAGE
  1368
DATE OF PUBLICATION
  1 Oct 2016
ISSN
  1943-3654 (electronic)
  0020-1324
BOOK PUBLISHER
  American Association for Respiratory Care
ABSTRACT
  BACKGROUND: Critically ill mechanically ventilated patients experience 
impaired airway clearance due to ineffective cough and impaired secretion 
mobilization. Cough augmentation techniques, including mechanical 
insufflation-exsufflation (MI-E), manually assisted cough, and lung volume 
recruitment, improve cough efficiency. Our objective was to describe use, 
indications, contraindications, interfaces, settings, complications, and 
barriers to use across Canada. METHODS: An e-mail survey was sent to 
nominated local survey champions in eligible Canadian units (ICUs, weaning 
centers, and intermediate care units) with 4 telephone/e-mail reminders. 
RESULTS: The survey response rate was 157 of 238 (66%); 78 of 157 units 
(50%) used cough augmentation, with 50 (64%) using MI-E, 53 (68%) using 
manually assisted cough, and 62 (79%) using lung volume recruitment. 
Secretion clearance was the most common indication (MI-E, 92%; manually 
assisted cough, 88%; lung volume recruitment, 76%), although the most common 
units (44%) used it <50% of the time. Use during weaning from invasive 
(MI-E, 21%; manually assisted cough, 39%; lung volume recruitment, 3%) and 
noninvasive ventilation (MI-E, 21%; manually assisted cough, 33%; lung 
volume recruitment, 21%) was infrequent. The most common diagnoses were 
neuromuscular disease (97%) and spinal cord injury (83%). Pneumothorax was 
the most frequently identified absolute contraindication for MI-E (93%) and 
lung volume recruitment (83%); rib fracture was most frequently identified 
for manually assisted cough (69%). MI-E mean inspiratory pressure was 31 cm 
H(2)O, and expiratory pressure was-32 cm H(2)O. Mucus plugging requiring 
tracheostomy inner change was the most frequent complication for MI-E (23%), 
chest pain for manually assisted cough (36%), and hypotension for lung 
volume recruitment (17%). The most commonly cited barriers were lack of 
expertise (70%), knowledge (65%), and resources (52%). CONCLUSIONS: We found 
moderate adoption of cough augmentation techniques, particularly for 
secretion management. Lack of expertise and knowledge are potentially 
modifiable barriers addressed with educational interventions.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  augmentation index; coughing; health care survey; 
EMTREE MEDICAL INDEX TERMS
  adult; article; chronic obstructive lung disease; clinical article; cross-sectional study; demography; female; human; hypotension; intervention study; knowledge; lung clearance; lung volume; male; middle aged; neuromuscular disease; positive end expiratory pressure; questionnaire; spinal cord injury; thorax pain; young adult; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Clinical and Experimental Biochemistry (29)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160705070
MEDLINE PMID
  27624630 (http://www.ncbi.nlm.nih.gov/pubmed/27624630)
PUI
  L612459540
DOI
  10.4187/respcare.04775
FULL TEXT LINK
  http://dx.doi.org/10.4187/respcare.04775
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19433654&id=doi:10.4187%2Frespcare.04775&atitle=Cough+augmentation+techniques+in+the+critically+ill%3A+A+canadian+national+survey&stitle=Respir.+Care&title=Respiratory+Care&volume=61&issue=10&spage=1360&epage=1368&aulast=Rose&aufirst=Louise&auinit=L.&aufull=Rose+L.&coden=RECAC&isbn=&pages=1360-1368&date=2016&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 245
TITLE
  Clinical Implications of Assisted Peak Cough Flow Measured With an External 
Glottic Control Device for Tracheostomy Decannulation in Patients With 
Neuromuscular Diseases and Cervical Spinal Cord Injuries: A Pilot Study
AUTHOR NAMES
  Kang S.-W.; Choi W.A.; Won Y.H.; Lee J.W.; Lee H.Y.; Kim D.J.
AUTHOR ADDRESSES
  (Kang S.-W., kswoong@yuhs.ac; Choi W.A.; Lee J.W.) Department of 
Rehabilitation Medicine, Gangnam Severance Hospital, Rehabilitation 
Institute of Neuromuscular Disease, Yonsei University College of Medicine, 
Seoul, South Korea.
(Won Y.H.) Research Institute of Clinical Medicine of Chonbuk National 
University, Biomechanical Research Institute of Chonbuk National University 
Hospital, Jeonju-si, South Korea.
(Lee H.Y.) Catholic University of Korea Catholic Medical Center National 
Traffic Injury Rehabilitation Hospital, Yangpyeong-gun, South Korea.
(Kim D.J.) Department of Rehabilitation Medicine, SRC Rehabilitation 
Hospital, Gwangju-si, South Korea.
CORRESPONDENCE ADDRESS
  S.-W. Kang, Department of Rehabilitation Medicine, Gangnam Severance 
Hospital, Rehabilitation Institute of Neuromuscular Disease, Yonsei 
University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul, South Korea. 
Email: kswoong@yuhs.ac
AiP/IP ENTRY DATE
  2016-06-03
FULL RECORD ENTRY DATE
  2016-10-25
SOURCE
  Archives of Physical Medicine and Rehabilitation (2016) 97:9 (1509-1514). 
Date of Publication: 1 Sep 2016
VOLUME
  97
ISSUE
  9
FIRST PAGE
  1509
LAST PAGE
  1514
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1532-821X (electronic)
  0003-9993
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Objective To investigate the clinical usefulness and significance of an 
external control device substituting for glottic function in determining the 
feasibility of decannulation in tracheostomized patients with neuromuscular 
diseases and cervical spinal cord injuries whose assisted peak cough flow 
(APCF) was unmeasurable or <160L/min. Design Before-after trial. Setting 
Inpatient setting in a university hospital. Participants Tracheostomized 
patients (N=16; 11 with neuromuscular diseases and 5 with cervical spinal 
cord injuries) were recruited. Interventions Unassisted peak cough flow 
(UPCF) and APCF were measured with and without an external glottic control 
device. Among patients whose APCF without the device was <160L/min, if their 
APCF with the device was measured as ≥160L/min, they were decannulated. 
After decannulation, UPCF and APCF were measured again. Main Outcome 
Measures APCF with and without an external glottic control device as well as 
APCF after decannulation. Results After successful decannulation, APCFs were 
greater than or equal to those measured with the device before 
decannulation. No patients underwent intubation or retracheostomy, and there 
were no respiratory complications. Conclusions The external glottic control 
device substituting for innate glottic function is beneficial for 
determining tracheostomy decannulation. It provides an objective and 
accurate APCF. It is particularly helpful for patients whose APCF is 
≥160L/min while using the device, even if APCF is <160L/min without this 
device.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  assisted peak cough flow; cervical spinal cord injury; external glottic control device; medical device; neuromuscular disease; respiratory tract parameters; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; clinical article; feasibility study; female; glottis; human; male; manual emergency ventilator; measurement accuracy; middle aged; peak flowmeter; pilot study; tracheostomy tube; unassisted peak cough flow; young adult; 
EMBASE CLASSIFICATIONS
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160401249
MEDLINE PMID
  27001502 (http://www.ncbi.nlm.nih.gov/pubmed/27001502)
PUI
  L610534845
DOI
  10.1016/j.apmr.2016.02.023
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2016.02.023
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1532821X&id=doi:10.1016%2Fj.apmr.2016.02.023&atitle=Clinical+Implications+of+Assisted+Peak+Cough+Flow+Measured+With+an+External+Glottic+Control+Device+for+Tracheostomy+Decannulation+in+Patients+With+Neuromuscular+Diseases+and+Cervical+Spinal+Cord+Injuries%3A+A+Pilot+Study&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=97&issue=9&spage=1509&epage=1514&aulast=Kang&aufirst=Seong-Woong&auinit=S.-W.&aufull=Kang+S.-W.&coden=APMHA&isbn=&pages=1509-1514&date=2016&auinit1=S&auinitm=-W
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 246
TITLE
  The timing of tracheotomy in cervical spinal cord injury patients: A 
retrospective study
AUTHOR NAMES
  Guirgis A.H.
AUTHOR ADDRESSES
  (Guirgis A.H.) Khoula Hospital, ICU, Muscat, Oman.
CORRESPONDENCE ADDRESS
  A.H. Guirgis, Khoula Hospital, ICU, Muscat, Oman.
FULL RECORD ENTRY DATE
  2017-08-29
SOURCE
  Intensive Care Medicine Experimental (2016) 4 Supplement 1. Date of 
Publication: 1 Sep 2016
VOLUME
  4
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  29th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2016
CONFERENCE LOCATION
  Milan, Italy
CONFERENCE DATE
  2016-10-01 to 2016-10-05
ISSN
  2197-425X
BOOK PUBLISHER
  SpringerOpen
ABSTRACT
  Introduction In Intensive Care Unit (ICU) per cutaneous tracheotomy plays a 
vital role in airway management of patients with Cervical Spinal Cord Injury 
(CSCI). This retrospective study evaluated the favorable effect of early 
tracheotomy in patients CSCI. OBJETICVES. To evaluate the timing of 
tracheotomy in patients with cervical injury and its effect on ICU stay 
Methods Retrospective data analysis of 72 patients with CSCI who underwent 
tracheotomy. The primary objective was to evaluate the impact of early 
tracheotomy(performed within 1 week of CSCI) on better outcome, in terms of 
days on mechanical ventilation and ICU stay in patients with high (C1, C2) 
and low (C3 to C7) CSCI. Outcome measures were also compared between the 
high and low CSCI patients when early tracheotomy was performed in both. In 
addition the impact of early tracheotomy in terms of survival benefit, 
ventilator dependence, requirement of inotropic medications, and whether 
surgical intervention resulted in better outcome in terms of days in 
mechanical ventilation and ICU stay were also analysed. Results Patients 
with high CSCI patients with early tracheotomy had significantly less days 
on mechanical ventilation and inotropic support compared to those with late 
tracheostomy (9.3+/-7.2 and 13.7 +/-3.2; p = 0.04 and 0.3+/-1.8 and 
4.7+/-11.4; p = 0.035 respectively). Low CSCI patients with early 
tracheotomy also had significantly less days on mechanical ventilation 
compared to those with late tracheotomy (12.1+/-10.4 and 25.2+/-17.7; p = 
0.034). Early tracheotomy resulted in significantly less days of inotropic 
support in high CSCI patients compared to low CSCI (0.3+/-1.8 and 2.7+/-5.6; 
p = 0.022). A trend was observed towards lesser ICU stay and days on 
mechanical ventilation in patients of high CSCI with early tracheotomy. 
There was no difference in terms of survival benefits, ventilator 
dependence, and impact of surgery on outcome measures Conclusions Our 
retrospective analysis supports the hypothesis that early tracheotomy is 
beneficial in reducing the period on mechanical ventilation and inotropic 
support in patients with CSCI, irrespective of the anatomical level of 
injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; retrospective study; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; controlled study; data analysis; female; human; inotropism; intensive care unit; major clinical study; surgery; survival; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617955226
DOI
  10.1186/s40635-016-0098-x
FULL TEXT LINK
  http://dx.doi.org/10.1186/s40635-016-0098-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2197425X&id=doi:10.1186%2Fs40635-016-0098-x&atitle=The+timing+of+tracheotomy+in+cervical+spinal+cord+injury+patients%3A+A+retrospective+study&stitle=Intensive+Care+Med.+Exp.&title=Intensive+Care+Medicine+Experimental&volume=4&issue=&spage=&epage=&aulast=Guirgis&aufirst=A.H.&auinit=A.H.&aufull=Guirgis+A.H.&coden=&isbn=&pages=-&date=2016&auinit1=A&auinitm=H
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 247
TITLE
  Tethered cord syndrome in a patient with 40-year history of spinal cord 
injury: A case report
AUTHOR NAMES
  Lazaro A.; Escalon M.X.; Zakhary M.
AUTHOR ADDRESSES
  (Lazaro A.) Mt Sinai Health System, New York, United States.
(Escalon M.X.; Zakhary M.)
CORRESPONDENCE ADDRESS
  A. Lazaro, Mt Sinai Health System, New York, United States.
FULL RECORD ENTRY DATE
  2016-11-07
SOURCE
  PM and R (2016) 8:9 Supplement (S272). Date of Publication: 1 Sep 2016
VOLUME
  8
ISSUE
  9
FIRST PAGE
  S272
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  2016 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation, AAPM and R 2016
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2016-10-20 to 2016-10-23
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case/Program Description: A 55-year-old man with chronic tetraplegia. The 
patient initially sustained cervical spinal cord injury following a lacrosse 
accident in 1977 and was subsequently C5 AIS A. He was placed in a halo with 
no surgical intervention. Neurologic examination stabilized with C5 function 
bilaterally. He was independent with power mobility, bed mobility with 
rails, feeding, shaving and could don and doff a shirt. He reported 
progressive neck pain and weakness involving biceps and deltoid function 
bilaterally starting 6 months prior to admission. Cervical spine MRI showed 
ventral tethering at C5-C6, dorsal tethering at C4, C6-7 and severe 
myelomalacia. He underwent C5-6 anterior cervical diskectomy and fusion, 
followed by C2-C7 laminectomies with intradural dethetering and fusion from 
C3- T1. Post-op course complicated by respiratory failure, with vent 
dependence requiring tracheostomy. Patient was transferred to spinal cord 
injury unit for acute inpatient rehabilitation on post-op day 18. Patient is 
now C4 AIS A. Setting: Tertiary care hospital Results: The patient regained 
1/5 muscle strength on C5 bilaterally. He was able to power manual 
wheelchair with lip control for 150 feet x2. He was weaned from ventilator 
and tracheostomy tube was downsized. While he did improve during inpatient 
rehabilitation stay, he did not regain prior level of function. Discussion: 
This case demonstrates neurologic decline in a patient with a 40-year 
history of spinal cord injury. It highlights the importance of early 
detection, management and rehabilitation of tethered cord and other late 
complications of chronic SCI such as progressive spondylosis or 
syringomelia. Conclusions: New or changing clinical features such as 
increasing weakness, pain, or muscle spasm may be a sign of late neurologic 
complication in chronic SCI that require prompt treatment in order to 
attempt prevention of potentially permanent neurologic decline.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tethered cord syndrome; 
EMTREE MEDICAL INDEX TERMS
  accident; adult; biceps brachii muscle; case report; clinical feature; complication; deltoid muscle; discectomy; dorsal region; feeding; foot; hospital patient; human; laminectomy; male; manual wheelchair; middle aged; muscle spasm; muscle strength; neck pain; nervous system; neurologic examination; neurological complication; nuclear magnetic resonance imaging; prevention; quadriplegia; rehabilitation; respiratory failure; spondylosis; surgery; tertiary care center; tracheostomy tube; ventilator; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L612983717
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Tethered+cord+syndrome+in+a+patient+with+40-year+history+of+spinal+cord+injury%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=8&issue=9&spage=S272&epage=&aulast=Lazaro&aufirst=Arlene&auinit=A.&aufull=Lazaro+A.&coden=&isbn=&pages=S272-&date=2016&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 248
TITLE
  Migration of anterior cervical fixation screw causing both esophageal and 
tracheal erosive injuries: Case report
AUTHOR NAMES
  Thuku G.I.; McKinley W.
AUTHOR ADDRESSES
  (Thuku G.I.) Virginia Commonwealth University, Richmond, United States.
(McKinley W.)
CORRESPONDENCE ADDRESS
  G.I. Thuku, Virginia Commonwealth University, Richmond, United States.
FULL RECORD ENTRY DATE
  2016-11-07
SOURCE
  PM and R (2016) 8:9 Supplement (S246). Date of Publication: 1 Sep 2016
VOLUME
  8
ISSUE
  9
FIRST PAGE
  S246
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  2016 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation, AAPM and R 2016
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2016-10-20 to 2016-10-23
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case/Program Description: A 34-year-old woman with history of IV drug use 
and prior back surgery presented with fever and acute mental changes. She 
was diagnosed with spinal epidural abscesses, cervical spinal cord 
compression and C5 motor incomplete tetraplegia. She underwent abscess 
drainage and ACF. Her acute hospital course was complicated by empyemas, 
pnuemothoracies and dysphagia. She required additional acute care procedures 
including: chest tubes, tracheostomy tube and percutaneous endoscopic 
feeding tube. After a prolonged stay in acute care, she was transferred to 
rehabilitation. At 6 weeks after ACF, a chest x-ray incidentally revealed a 
metallic object (resembling a screw) in the right medial lung base. 
Subsequent imaging work-up revealed that a screw was missing from the ACF 
plate. Bronchoscopy revealed a tracheal perforation and screw in the 
posterior bronchus of the right medial lobe. Modified barium swallow 
identified an esophageal perforation. The screw and ACF hardware were 
removed and tracheal injury was repaired. Unsuccessful conservative 
management was attempted for the esophageal injury, which eventually 
required surgical closure. Setting: A Tertiary Referral Hospital. Results: 
Patient did very well and after 6 months follow-up was eating a regular diet 
without respiratory issues. Discussion: We present a unique case of anterior 
cervical fusion (ACF) screw extrusion and migration, with resultant 
simultaneous esophageal and tracheal injuries in a very common procedure, 
with more than 100,000 performed annually. Conclusions: Esophageal and 
tracheal perforations can occur simultaneously with ACF screw extrusion and 
migration. Coexisting respiratory and swallowing issues may pose 
difficulties with diagnosis of such injuries and recommendations for regular 
hardware image surveillance are needed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus perforation; trachea injury; 
EMTREE MEDICAL INDEX TERMS
  abscess drainage; adult; bronchoscopy; bronchus; case report; cervical spinal cord; chest tube; compression; computer; conservative treatment; diagnosis; diet; dysphagia; eating; emergency care; empyema; epidural abscess; esophagography; feeding apparatus; female; fever; follow up; human; imaging; lung; mental disease; quadriplegia; rehabilitation; surgery; tertiary care center; thorax radiography; tracheostomy tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L612984431
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Migration+of+anterior+cervical+fixation+screw+causing+both+esophageal+and+tracheal+erosive+injuries%3A+Case+report&stitle=PM+R&title=PM+and+R&volume=8&issue=9&spage=S246&epage=&aulast=Thuku&aufirst=Godfrey+I.&auinit=G.I.&aufull=Thuku+G.I.&coden=&isbn=&pages=S246-&date=2016&auinit1=G&auinitm=I
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 249
TITLE
  Lifesaving cyclophosphamide for fulminant multiple sclerosis: A case report
AUTHOR NAMES
  Kumar G.; Sanchez V.; Brex P.; Coles A.; Harikrishnan S.
AUTHOR ADDRESSES
  (Kumar G.; Sanchez V.; Harikrishnan S.) Department of Neurology, Treble 
Ward, Kent and Canterbury Hospital, East Kent University Hospitals NHS 
Trust, Canterbury, United Kingdom.
(Brex P.) Department of Neurology, Kings College Hospital, King's College 
Hospital NHS Foundation Trust, London, United Kingdom.
(Coles A.) Department of Clinical Neurosciences, University of Cambridge, 
Cambridge, United Kingdom.
CORRESPONDENCE ADDRESS
  G. Kumar, Department of Neurology, Treble Ward, Kent and Canterbury 
Hospital, East Kent University Hospitals NHS Trust, Canterbury, United 
Kingdom.
FULL RECORD ENTRY DATE
  2016-10-03
SOURCE
  Multiple Sclerosis (2016) 22 Supplement 3 (778). Date of Publication: 1 Sep 
2016
VOLUME
  22
FIRST PAGE
  778
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  32nd Congress of the European Committee for Treatment and Research in 
Multiple Sclerosis, ECTRIMS 2016
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2016-09-14 to 2016-09-17
ISSN
  1477-0970
BOOK PUBLISHER
  SAGE Publications Ltd
ABSTRACT
  Background: Cyclophosphamide is a cytotoxic agent occasionally used to treat 
inflammatory conditions of the nervous system. We present an exceptional 
case of its successful use to treat a first presentation of life threatening 
Multiple Sclerosis (MS). Case: A 31 year old Caucasian female, with 
background of opiate addiction presented with six month history of 
unsteadiness, falls and confusion. Initial examination demonstrated 
pyramidal weakness, hyper-reflexia, cerebellar signs, and cognitive 
impairment. Six days into admission she suffered respiratory compromise 
requiring intubation and mechanical ventilation. Magnetic Resonance Imaging 
demonstrated global cerebral atrophy and multiple widespread, confluent, 
partially-enhancing T2 and FLAIR white matter hyperintensities throughout 
both cerebral hemispheres, brainstem, cerebellum and cervical spinal cord. 
This was felt to most likely represent a demyelinating pathology. 
Investigations for other inflammatory, infective, toxic, metabolic, 
neurodegenerative or autoimmune conditions were negative. Cerebrospinal 
fluid was acellular but significant for the presence of oligoclonal bands. A 
clinical diagnosis of demyelinating disease, likely MS, was obtained. She 
was initially treated with high dose steroids (pulsed intravenous 
methylprednisolone for a total for eight days and then subsequently oral 
prednisolone) and five cycles of plasma exchange achieving only mild 
improvement. She remained in high dependency care 27 days into admission, 
still requiring tracheostomy, enteral feeding and fully dependant on nursing 
care; equating to Expanded Disability Status Scale (EDSS) of 9.5. 
Immunosuppression was escalated to six cycles of cyclophosphamide (15mg/kg) 
in two week intervals. Subsequently there was a dramatic improvement; she 
began to talk fluently on day 51 and walk independently after day 91. 
Currently, she remains globally cognitively impaired (Addenbrooke's 
Cognitive Examination Score 42/100) and has subtle pyramidal weakness in her 
right arm only; giving EDSS 4.5. To date, she has not exhibited signs of 
cyclophosphamide toxicity and there has been no progression of radiological 
findings. Conclusion: This case highlights the remarkable outcome that can 
be achieved from using potentially toxic immunosuppression in the context of 
first presentation of highly aggressive MS, even when initiated in a 
critical care setting.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cyclophosphamide; 
EMTREE DRUG INDEX TERMS
  methylprednisolone; oligoclonal band; prednisolone; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  multiple sclerosis; 
EMTREE MEDICAL INDEX TERMS
  adult; brain atrophy; brain stem; case report; Caucasian; cerebrospinal fluid; cervical spinal cord; cognitive defect; diagnosis; enteric feeding; Expanded Disability Status Scale; female; hemisphere; human; hyperreflexia; immunosuppressive treatment; intubation; nuclear magnetic resonance imaging; nursing care; opiate addiction; pathology; plasma exchange; toxicity; tracheostomy; unsteadiness; weakness; white matter; 
CAS REGISTRY NUMBERS
  cyclophosphamide (50-18-0)
  methylprednisolone (6923-42-8, 83-43-2)
  prednisolone (50-24-8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L612359866
DOI
  10.1177/1352458516663067
FULL TEXT LINK
  http://dx.doi.org/10.1177/1352458516663067
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14770970&id=doi:10.1177%2F1352458516663067&atitle=Lifesaving+cyclophosphamide+for+fulminant+multiple+sclerosis%3A+A+case+report&stitle=Mult.+Scler.&title=Multiple+Sclerosis&volume=22&issue=&spage=778&epage=&aulast=Kumar&aufirst=G.&auinit=G.&aufull=Kumar+G.&coden=&isbn=&pages=778-&date=2016&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 250
TITLE
  Variation in 60-day Readmission for Surgical-site Infections (SSIs) and 
Reoperation Following Spinal Fusion Operations for Neuromuscular Scoliosis
AUTHOR NAMES
  McLeod L.; Flynn J.; Erickson M.; Miller N.; Keren R.; Dormans J.
AUTHOR ADDRESSES
  (McLeod L., lisa.mcleod@childrenscolorado.org) Section of Hospital Medicine, 
Children's Hospital Colorado, United States.
(Erickson M.; Miller N.) Division of Orthopedic Surgery, Children's Hospital 
Colorado, Aurora, United States.
(Flynn J.; Dormans J.) Division of Orthopedic Surgery, Children's Hospital 
of Philadelphia, United States.
(Keren R.) Department of Pediatrics, Children's Hospital of Philadelphia, 
Philadelphia, United States.
(McLeod L., lisa.mcleod@childrenscolorado.org) Section of Hospital Medicine, 
Children's Hospital Colorado, 13123 East 16th Ave., B290, Aurora, United 
States.
AiP/IP ENTRY DATE
  2016-09-07
FULL RECORD ENTRY DATE
  2016-09-15
SOURCE
  Journal of Pediatric Orthopaedics (2016) 36:6 (634-639). Date of 
Publication: 1 Sep 2016
VOLUME
  36
ISSUE
  6
FIRST PAGE
  634
LAST PAGE
  639
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1539-2570 (electronic)
  0271-6798
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Background: Readmission for surgical-site infection (SSIs) following spinal 
fusion for NMS impacts costs, patient risk, and family burden; however, it 
may be preventable. The purpose of this study was to examine variation in 
hospital performance based on risk-standardized 60-day readmission rates for 
SSI and reoperation across 39 US Children's Hospitals. Methods: 
Retrospective cohort study using the Pediatric Health Information Systems 
(PHIS) database involving children aged 10 to 18 years with ICD9 codes 
indicating spinal fusion, scoliosis, and neuromuscular disease discharged 
from 39 US children's hospitals between January 1, 2007 and September 1, 
2012. Readmissions within 60 days for SSI were identified based on the 
presence of ICD9 codes for (1) infectious complication of device or 
procedure, or (2) sepsis or specific bacterial infection with an 
accompanying reoperation. Logistic regression models accounting for 
patient-level risk factors for SSI were used to estimate expected 
(patient-level risk across all hospitals) and predicted (weighted average of 
hospital-specific and all-hospital estimates) outcomes. Relative performance 
was determined using the hospital-specific predicted versus expected (pe) 
ratios. Results: Average volume across hospitals ranged from 2 to 23 
fusions/quarter and was not associated with readmissions. Of the 7560 
children in the cohort, 534 (7%) were readmitted for reoperation and 451 
(6%) were readmitted for SSI within 60 days of discharge. Reoperations were 
associated with an SSI in 70% of cases. Across hospitals, SSI and 
reoperation rates ranged from 1% to 11% and 1% to 12%, respectively. After 
adjusting for age, sex, insurance, presence of a gastric tube, 
ventriculoperitoneal shunt, tracheostomy, prior admissions, number of 
chronic conditions, procedure type (anterior/posterior), and level (>9 or <9 
vertebrae), pe ratios indicating hospital performance varied by 2-fold for 
each outcome. Conclusions: After standardizing outcomes using patient-level 
factors and relative case mix, several hospitals in this cohort were more 
successful at preventing readmissions for SSIs and reoperations. Closer 
examination of the organization and implementation of strategies for SSI 
prevention at high-performing centers may offer valuable clues for improving 
care at lower performing institutions. Level of Evidence: Level III.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spine fusion; child hospitalization; Duchenne muscular dystrophy (surgery); hospital readmission; infection prevention; posterior spine fusion; reoperation; scoliosis (surgery); spinal muscular atrophy (surgery); surgical infection (complication, prevention); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; bacterial infection (complication); brain ventricle peritoneum shunt; child; chronic disease; cohort analysis; female; groups by age; health insurance; hospital discharge; human; ICD-9; major clinical study; male; medical information system; multicenter study; outcome assessment; priority journal; retrospective study; risk factor; sepsis (complication); sex difference; stomach tube; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160632270
MEDLINE PMID
  25929778 (http://www.ncbi.nlm.nih.gov/pubmed/25929778)
PUI
  L611933343
DOI
  10.1097/BPO.0000000000000495
FULL TEXT LINK
  http://dx.doi.org/10.1097/BPO.0000000000000495
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15392570&id=doi:10.1097%2FBPO.0000000000000495&atitle=Variation+in+60-day+Readmission+for+Surgical-site+Infections+%28SSIs%29+and+Reoperation+Following+Spinal+Fusion+Operations+for+Neuromuscular+Scoliosis&stitle=J.+Pediatr.+Orthop.&title=Journal+of+Pediatric+Orthopaedics&volume=36&issue=6&spage=634&epage=639&aulast=McLeod&aufirst=Lisa&auinit=L.&aufull=McLeod+L.&coden=JPORD&isbn=&pages=634-639&date=2016&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 251
TITLE
  Safety profile and probe placement accuracy of intraspinal pressure 
monitoring for traumatic spinal cord injury: Injured spinal cord pressure 
evaluation study
AUTHOR NAMES
  Phang I.; Zoumprouli A.; Saadoun S.; Papadopoulos M.C.
AUTHOR ADDRESSES
  (Phang I.; Saadoun S.; Papadopoulos M.C., mpapadop@sgul.ac.uk) Academic 
Neurosurgery Unit, St. George's, University of London, Department of 
Neurosurgery, Atkinson Morley Wing, St. George's Hospital, London, United 
Kingdom.
(Zoumprouli A.) Neurointensive Care Unit, St. George's Hospital, London, 
United Kingdom.
CORRESPONDENCE ADDRESS
  M.C. Papadopoulos, Academic Neurosurgery Unit, St. George's, University of 
London, Department of Neurosurgery, Atkinson Morley Wing, St. George's 
Hospital, London, United Kingdom. Email: mpapadop@sgul.ac.uk
AiP/IP ENTRY DATE
  2016-09-15
FULL RECORD ENTRY DATE
  2016-09-20
SOURCE
  Journal of Neurosurgery: Spine (2016) 25:3 (398-405). Date of Publication: 1 
Sep 2016
VOLUME
  25
ISSUE
  3
FIRST PAGE
  398
LAST PAGE
  405
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1547-5646 (electronic)
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons, jnevro@virginia.edu
ABSTRACT
  OBJECTIVE: A novel technique for monitoring intraspinal pressure and spinal 
cord perfusion pressure in patients with traumatic spinal cord injury was 
recently described. This is analogous to monitoring intracranial pressure 
and cerebral perfusion pressure in patients with traumatic brain injury. 
Because intraspinal pressure monitoring is a new technique, its safety 
profile and impact on early patient care and long-term outcome after 
traumatic spinal cord injury are unknown. The object of this study is to 
review all patients who had intraspinal pressure monitoring to date at the 
authors' institution in order to define the accuracy of intraspinal pressure 
probe placement and the safety of the technique. METHODS: At the end of 
surgery to fix spinal fractures, a pressure probe was inserted intradurally 
to monitor intraspinal pressure at the injury site. Postoperatively, CT 
scanning was performed within 48 hours and MRI at 2 weeks and 6 months. 
Neurointensive care management and complications were reviewed. The American 
Spinal Injury Association Impairment Scale (AIS) grade was determined on 
admission and at 2 to 4 weeks and 12 to 18 months postoperation. RESULTS: To 
date, 42 patients with severe traumatic spinal cord injuries (AIS Grades 
A-C) had undergone intraspinal pressure monitoring. Monitoring started 
within 72 hours of injury and continued for up to a week. Based on 
postoperative CT and MRI, the probe position was acceptable in all patients, 
i.e., the probe was located at the site of maximum spinal cord swelling. 
Complications were probe displacement in 1 of 42 patients (2.4%), CSF 
leakage that required wound resuturing in 3 of 42 patients (7.1%), and 
asymptomatic pseudomeningocele that was diagnosed in 8 of 42 patients 
(19.0%). Pseudomeningocele was diagnosed on MRI and resolved within 6 months 
in all patients. Based on the MRI and neurological examination results, 
there were no serious probe-related complications such as meningitis, wound 
infection, hematoma, wound breakdown, or neurological deterioration. Within 
2 weeks postoperatively, 75% of patients were extubated and 25% underwent 
tracheostomy. Norepinephrine was used to support blood pressure without 
complications. Overall, the mean intraspinal pressure was around 20 mm Hg, 
and the mean spinal cord perfusion pressure was around 70 mm Hg. In 
laminectomized patients, the intraspinal pressure was significantly higher 
in the supine than lateral position by up to 18 mm Hg after thoracic 
laminectomy and 8 mm Hg after cervical laminectomy. At 12 to 18 months, 
11.4% of patients had improved by 1 AIS grade and 14.3% by at least 2 AIS 
grades. CONCLUSIONS: These data suggest that after traumatic spinal cord 
injury intradural placement of the pressure probe is accurate and 
intraspinal pressure monitoring is safe for up to a week. In patients with 
spinal cord injury who had laminectomy, the supine position should be 
avoided in order to prevent rises in intraspinal pressure.
EMTREE DRUG INDEX TERMS
  dalteparin (drug therapy, subcutaneous drug administration); noradrenalin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intraspinal pressure monitoring; monitor; pressure measurement; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; article; clinical article; computer assisted tomography; evaluation study; female; hematoma (complication); human; intensive care; laminectomy; liquorrhea (complication, surgery); male; meningitis (complication); mental deterioration (complication); neurologic examination; nuclear magnetic resonance imaging; patient positioning; patient safety; perfusion pressure; postoperative complication (complication, diagnosis); postoperative period; pseudomeningocele (complication, diagnosis); spine fracture; supine position; surgical approach; surgical technique; surgical wound (complication); thrombosis (drug therapy, prevention); thrombosis prevention; tracheostomy; wound infection (complication); 
DEVICE TRADE NAMES
  MX800 bedside monitoring system  Philips

DEVICE MANUFACTURERS
  Philips
CAS REGISTRY NUMBERS
  noradrenalin (1407-84-7, 51-41-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160657635
MEDLINE PMID
  27129044 (http://www.ncbi.nlm.nih.gov/pubmed/27129044)
PUI
  L612106221
DOI
  10.3171/2016.1.SPINE151317
FULL TEXT LINK
  http://dx.doi.org/10.3171/2016.1.SPINE151317
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475646&id=doi:10.3171%2F2016.1.SPINE151317&atitle=Safety+profile+and+probe+placement+accuracy+of+intraspinal+pressure+monitoring+for+traumatic+spinal+cord+injury%3A+Injured+spinal+cord+pressure+evaluation+study&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=25&issue=3&spage=398&epage=405&aulast=Phang&aufirst=Isaac&auinit=I.&aufull=Phang+I.&coden=&isbn=&pages=398-405&date=2016&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 252
TITLE
  Congenital neuromuscular diseases with neonatal respiratory failure 
excluding myotonic dystrophy type 1 and infantile spinal muscular atrophy. 
Diagnosis strategy according to a 19-child series
ORIGINAL (NON-ENGLISH) TITLE
  Maladies neuromusculaires congénitales à expression respiratoire néonatale à 
l'exclusion de la dystrophie myotonique de type 1 et de l'amyotrophie 
spinale infantile. Stratégie d'exploration d'après une série de 19 enfants
AUTHOR NAMES
  Raignoux J.; Walther-Louvier U.; Espil C.; Berthomieu L.; Uro-Coste E.; Rivier F.; Cances C.
AUTHOR ADDRESSES
  (Raignoux J.; Cances C., cances.c@chu-toulouse.fr) Unité de neuropédiatrie, 
CHU de Toulouse, Toulouse, France.
(Walther-Louvier U.; Rivier F.) Service de neuropédiatrie, CHU de 
Montpellier, Montpellier, France.
(Espil C.) Service de neuropédiatrie, CHU de Bordeaux, Bordeaux, France.
(Berthomieu L.) Service de réanimation néonatale et pédiatrique, CHU de 
Toulouse, Toulouse, France.
(Uro-Coste E.) Service d'anatomopathologie, CHU de Toulouse, Toulouse, 
France.
CORRESPONDENCE ADDRESS
  C. Cances, Unité de neuropédiatrie, CHU de Toulouse, Toulouse, France. 
Email: cances.c@chu-toulouse.fr
AiP/IP ENTRY DATE
  2016-07-25
FULL RECORD ENTRY DATE
  2016-11-02
SOURCE
  Archives de Pediatrie (2016) 23:9 (878-886). Date of Publication: 1 Sep 2016
VOLUME
  23
ISSUE
  9
FIRST PAGE
  878
LAST PAGE
  886
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1769-664X (electronic)
  0929-693X
BOOK PUBLISHER
  Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex, 
France.
ABSTRACT
  Apart from spinal muscular atrophy (SMA) and myotonic dystrophy type 1 
(DM1), congenital neuromuscular diseases with early neonatal symptoms mean 
diagnostic and prognostic challenges mainly when infants require ventilatory 
support. Objectives Consider a standardized strategy for infants suspected 
of congenital neuromuscular disease from analysis of the literature and 
retrospective experience with floppy and ventilatory support-dependent 
infants, after exclusion of well-known diseases (DM1, SMA). Patients and 
methods Floppy infants requiring ventilatory support in their 1st month of 
life, but showing no evidence of DM1, SMA, Prader-Willi syndrome, or 
encephalopathy. The retrospective multicenter study was based on the 
response of regional referent neuropediatricians in the Reference Centre for 
Neuromuscular Diseases of Greater Southwest France to an inquiry about 
prenatal and perinatal history, investigations, diagnosis, and outcome of 
the child and family. It was conducted between 2007 and 2012. Results Among 
the 19 newborns studied, all had severe hypotonia. Prenatal and perinatal 
features were similar. Their outcome was generally severe: the median 
survival as measured by the Kaplan-Meier method was 6.9 months. Thirteen 
children died at a median age of 61 days; ten of them were treated with a 
palliative procedure. Five children had achieved respiratory independence 
but suffered from a small delay in motor development. Among the three 
children who continuously required ventilatory support, only one survived 
(follow-up period: 23 months); he was the only one undergoing tracheostomy 
in the cohort. Diagnostic processes were different, leading to pathological 
and genetic diagnosis for only six infants. There was only histological 
orientation for seven and no specific diagnostic orientation for the last 
six. These difficulties have led us to propose an exploration process based 
on the literature. Conclusion This study highlights difficulties in 
obtaining a diagnosis and a precise prognosis for floppy ventilated infants. 
An exploration-standardized process for infants suspected of congenital 
neuromuscular diseases was made in order to standardize procedures. It could 
be used as a tool for all professionals involved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myotonic dystrophy; neuromuscular disease (congenital disorder); respiratory failure; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  article; brain disease; clinical article; developmental disorder; disease severity; human; infant; muscle hypotonia; Prader Willi syndrome; retrospective study; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English, French
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  20160532972
MEDLINE PMID
  27375179 (http://www.ncbi.nlm.nih.gov/pubmed/27375179)
PUI
  L611282062
DOI
  10.1016/j.arcped.2016.05.019
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.arcped.2016.05.019
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1769664X&id=doi:10.1016%2Fj.arcped.2016.05.019&atitle=Congenital+neuromuscular+diseases+with+neonatal+respiratory+failure+excluding+myotonic+dystrophy+type+1+and+infantile+spinal+muscular+atrophy.+Diagnosis+strategy+according+to+a+19-child+series&stitle=Arch.+Pediatr.&title=Archives+de+Pediatrie&volume=23&issue=9&spage=878&epage=886&aulast=Raignoux&aufirst=J.&auinit=J.&aufull=Raignoux+J.&coden=APEDE&isbn=&pages=878-886&date=2016&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 253
TITLE
  Therapeutic hypothermia in neonatal cervical spine injury
AUTHOR NAMES
  Montaldo P.; Oliveira V.; Lally P.J.; Chaban B.; Atreja G.; Kirmi O.; Thayyil S.
AUTHOR ADDRESSES
  (Montaldo P., p.montaldo@imperial.ac.uk; Oliveira V.; Lally P.J.; Chaban B.; 
Atreja G.; Thayyil S.) Centre for Perinatal Neuroscience, Imperial College 
London, Du Cane Road, London, United Kingdom.
(Kirmi O.) Department of Neuroradiology, Imperial College Healthcare NHS 
Trust, London, United Kingdom.
CORRESPONDENCE ADDRESS
  P. Montaldo, Centre for Perinatal Neuroscience, Imperial College London, Du 
Cane Road, London, United Kingdom. Email: p.montaldo@imperial.ac.uk
AiP/IP ENTRY DATE
  2016-09-16
FULL RECORD ENTRY DATE
  2016-09-22
SOURCE
  Archives of Disease in Childhood: Fetal and Neonatal Edition (2016) 101:5 
(F468). Date of Publication: 1 Sep 2016
VOLUME
  101
ISSUE
  5
FIRST PAGE
  F468
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1468-2052 (electronic)
  1359-2998
BOOK PUBLISHER
  BMJ Publishing Group, subscriptions@bmjgroup.com
EMTREE DRUG INDEX TERMS
  lactic acid; n acetylaspartic acid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (therapy); induced hypothermia; newborn disease (therapy); 
EMTREE MEDICAL INDEX TERMS
  Apgar score; arm weakness; assisted ventilation; breathing; case report; contusion; cooling; disease severity; electroencephalography; human; hypoxic ischemic encephalopathy; male; newborn; note; nuclear magnetic resonance imaging; priority journal; quadriplegia; shoulder dystocia (therapy); tendon reflex; tracheostomy; 
CAS REGISTRY NUMBERS
  lactic acid (113-21-3, 50-21-5)
  n acetylaspartic acid (22304-28-5, 997-55-7)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160659869
MEDLINE PMID
  27189480 (http://www.ncbi.nlm.nih.gov/pubmed/27189480)
PUI
  L612046626
DOI
  10.1136/archdischild-2016-310690
FULL TEXT LINK
  http://dx.doi.org/10.1136/archdischild-2016-310690
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14682052&id=doi:10.1136%2Farchdischild-2016-310690&atitle=Therapeutic+hypothermia+in+neonatal+cervical+spine+injury&stitle=Arch.+Dis.+Child.+Fetal+Neonatal+Ed.&title=Archives+of+Disease+in+Childhood%3A+Fetal+and+Neonatal+Edition&volume=101&issue=5&spage=F468&epage=&aulast=Montaldo&aufirst=Paolo&auinit=P.&aufull=Montaldo+P.&coden=ADCHA&isbn=&pages=F468-&date=2016&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 254
TITLE
  Length of stay of Spinal Cord Injury (SCI) patients and their outcome while 
in Neuro ICU
AUTHOR NAMES
  Hilasque C.
AUTHOR ADDRESSES
  (Hilasque C.) St. George's Healthcare Trust, Neuro ICU, London, United 
Kingdom.
CORRESPONDENCE ADDRESS
  C. Hilasque, St. George's Healthcare Trust, Neuro ICU, London, United 
Kingdom.
FULL RECORD ENTRY DATE
  2017-08-29
SOURCE
  Intensive Care Medicine Experimental (2016) 4 Supplement 1. Date of 
Publication: 1 Sep 2016
VOLUME
  4
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  29th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2016
CONFERENCE LOCATION
  Milan, Italy
CONFERENCE DATE
  2016-10-01 to 2016-10-05
ISSN
  2197-425X
BOOK PUBLISHER
  SpringerOpen
ABSTRACT
  Introduction Why do patients with Spinal Cord Injury (SCI) stay in Neuro ICU 
for a long time? Objectives A survey about the reasons why SCI patients 
stayed longer in NICU between 2013 and 2015 and their outcome Methods A 
local database (Wardwatcher) was used to search and collection of data for 
patients admitted with SCI between 2013 and 2015. Results Out of 3,539 
admissions in NICU, 326 cases were related to spinal injury and 137 were 
considered as spinal cord injury and 93 % of admissions were related to 
trauma and 6 patients were readmitted while in the hospital between 2013 and 
2015. There was an increase trend of admissions in NICU between 2013 and 
2015 and the data showed that the average length number of days of patient 
stay was 3.6 days while spinal patients were 8.6 days. The Guidelines for 
the Provision of Intensive Care Services (2015) recommends a discharge from 
critical care to ward must be within 4 hours from the decision of the 
consultant, the data showed that 71 % of between 9 to 14 hours delayed 
discharges from NICU to ward are mainly caused by shortage of ward beds 
followed by delay on ward. 60-66 % of SCI patients required advance cardiac 
and respiratory organ support and 36 % were on neurological support. 86 % of 
the patients had tracheostomy. Only 19 patients were qualified for SCI study 
called Injured Spinal Cord Pressure Evaluation (ISCoPE) where the 
intraspinal pressure was measured in relation to traumatic spinal cord 
injury and this requires the patient to be in the spinal monitoring pressure 
for at least 7 days. On patients outcome, 75 % had improved, 13 % died and 
12 % of the patients remain unchanged. While the hospital patient outcome on 
discharge, 83 % lived and 17 % died. Conclusions Though there were not many 
SCI patients admitted in the unit compared to other patients. SCI patients 
stayed longer by 5 days on average. Three main reasons were identified why 
they stayed longer; one was because of ISCoPE research, the other one was 
their dependency on advance organ support and lastly, the delayed discharges 
because of shortage of ward beds. The delayed discharges could indicate that 
the hospital needs to increase the bed capacity. The patients' outcome 
appears encouraging with their improved outcome. A further audit is 
necessary to see any changes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  female; length of stay; male; neurological intensive care unit; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  consensus development; consultation; controlled study; data base; evaluation research; heart; hospital bed capacity; hospital patient; human; major clinical study; monitoring; organ; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617955270
DOI
  10.1186/s40635-016-0098-x
FULL TEXT LINK
  http://dx.doi.org/10.1186/s40635-016-0098-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2197425X&id=doi:10.1186%2Fs40635-016-0098-x&atitle=Length+of+stay+of+Spinal+Cord+Injury+%28SCI%29+patients+and+their+outcome+while+in+Neuro+ICU&stitle=Intensive+Care+Med.+Exp.&title=Intensive+Care+Medicine+Experimental&volume=4&issue=&spage=&epage=&aulast=Hilasque&aufirst=C.&auinit=C.&aufull=Hilasque+C.&coden=&isbn=&pages=-&date=2016&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 255
TITLE
  Surgical outcomes for acute type A aortic dissection with aggressive primary 
entry resection
AUTHOR NAMES
  Inoue Y.; Minatoya K.; Oda T.; Itonaga T.; Seike Y.; Tanaka H.; Sasaki H.; Kobayashi J.
AUTHOR ADDRESSES
  (Inoue Y.; Minatoya K., minatoya@ncvc.go.jp; Oda T.; Itonaga T.; Seike Y.; 
Tanaka H.; Sasaki H.; Kobayashi J.) Department of Cardiovascular surgery, 
National Cerebral and Cardiovascular Center, Osaka, Japan.
CORRESPONDENCE ADDRESS
  K. Minatoya, Department of Cardiovascular surgery, National Cerebral and 
Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan. Email: 
minatoya@ncvc.go.jp
AiP/IP ENTRY DATE
  2016-10-19
FULL RECORD ENTRY DATE
  2016-10-26
SOURCE
  European Journal of Cardio-thoracic Surgery (2016) 50:3 (567-573) Article 
Number: ezw111. Date of Publication: 1 Sep 2016
VOLUME
  50
ISSUE
  3
FIRST PAGE
  567
LAST PAGE
  573
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1873-734X (electronic)
  1010-7940
BOOK PUBLISHER
  European Association for Cardio-Thoracic Surgery, info@eacts.co.uk
ABSTRACT
  OBJECTIVES: An entry located at aortic arch in acute type A aortic 
dissection (AAAD) is uncommon. It remains controversial whether or not 
aggressive primary entry resection should be routinely performed in such 
patients. We have adopted an aggressive strategy of entry site resection, 
including total arch replacement (TAR) in patients with arch tears. The 
purpose of this study was to investigate the efficacy of our surgical 
management approach, using aggressive primary entry resection. METHODS: 
Between January 2000 and December 2014, we retrospectively reviewed the 
records of 334 patients with AAAD who underwent emergent surgery. The mean 
age was 67 ± 13 years (range, 20-95 years). Ninety-five patients (28%) 
presented with shock vital status, and 84 patients (25%) manifested 
malperfusion of branched arteries. Primary entry resection was achieved in 
95% of patients under an aggressive surgical strategy [hemiarch replacement 
for 173 (52%) patients and TAR for 161 (48%) patients] concomitant with 22 
coronary artery bypass grafts and 38 root replacements. Ninety-six percent 
of hospital survivors (298/311) were followed for a median of 39 months 
(range, 0-179 months). RESULTS: Operation, cardiopulmonary bypass, cardiac 
arrest, antegrade cerebral perfusion and lower body circulatory arrest times 
were 447 ± 170, 236 ± 93, 112 ± 74, 115 ± 81 and 54 ± 18 min, respectively. 
The 30-day mortality rate was 5.4%. The in-hospital mortality rate was 8.4% 
(6.9% at our hospital). Incidences of postoperative permanent neurological 
dysfunction, tracheotomy and newly permanent haemodialysis were 6.9, 8 and 
2%, respectively, with no spinal cord injuries observed. Complete false 
lumen thrombosis was achieved in 57% of patients as visualized by 
postoperative computed tomography angiography. After 3, 5 and 10 years, 
overall survival rates were 81, 74 and 65%, respectively, and the 
percentages of patients free from downstream dissection-related reoperation 
were 89, 86 and 80%, respectively. Multivariable analysis demonstrated that 
the risk factors for downstream aortic reoperation were patent false lumen, 
residual primary entry tear and connective tissue disorder. CONCLUSIONS: The 
surgical outcomes following aggressive treatment of AAAD are satisfactory. 
False lumen thrombosis can be achieved in a relatively high proportion of 
patients using this technique, resulting in a low rate of subsequent 
downstream aortic reoperations.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute disease (surgery); acute type A aortic dissection (surgery); aggressive primary entry resection; aortic dissection (surgery); aortic surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; aortic root surgery; article; brain perfusion; cardiopulmonary bypass; cardiovascular mortality; computer assisted tomography; connective tissue disease; coronary artery bypass graft; emergency surgery; female; follow up; heart arrest; hemodialysis; hospital mortality; human; life expectancy; major clinical study; male; neurologic disease (complication); operation duration; outcome assessment; overall survival; postoperative complication (complication); priority journal; reoperation; retrospective study; shock; spinal cord injury (complication); surgical mortality; tracheostomy; tracheotomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160736783
MEDLINE PMID
  27044900 (http://www.ncbi.nlm.nih.gov/pubmed/27044900)
PUI
  L612707093
DOI
  10.1093/ejcts/ezw111
FULL TEXT LINK
  http://dx.doi.org/10.1093/ejcts/ezw111
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1873734X&id=doi:10.1093%2Fejcts%2Fezw111&atitle=Surgical+outcomes+for+acute+type+A+aortic+dissection+with+aggressive+primary+entry+resection&stitle=Eur.+J.+Cardio-thorac.+Surg.&title=European+Journal+of+Cardio-thoracic+Surgery&volume=50&issue=3&spage=567&epage=573&aulast=Inoue&aufirst=Yosuke&auinit=Y.&aufull=Inoue+Y.&coden=EJCSE&isbn=&pages=567-573&date=2016&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 256
TITLE
  A severe spinal muscular atrophy phenotype associated with a novel BICD2 
mutation
AUTHOR NAMES
  Kichula E.A.; Medne L.; Zackai E.H.; Estilow T.; Harding B.; Banwell B.; Yum S.W.
AUTHOR ADDRESSES
  (Kichula E.A.; Medne L.; Estilow T.; Harding B.; Banwell B.; Yum S.W.) 
Neuromuscular Program of The Children's Hospital of Philadelphia, 
Philadelphia, United States.
(Harding B.) Department of Pathology, Perelman School of Medicine, 
University of Pennsylvania, Philadelphia, United States.
(Zackai E.H.) Department of Genetics, Children's Hospital of Philadelphia, 
Philadelphia, United States.
(Banwell B.; Yum S.W.) Department of Neurology, Perelman School of Medicine, 
University of Pennsylvania, Philadelphia, United States.
CORRESPONDENCE ADDRESS
  E.A. Kichula, Neuromuscular Program of The Children's Hospital of 
Philadelphia, Philadelphia, United States.
FULL RECORD ENTRY DATE
  2017-09-01
SOURCE
  Journal of the Peripheral Nervous System (2016) 21:3 (269). Date of 
Publication: 1 Sep 2016
VOLUME
  21
ISSUE
  3
FIRST PAGE
  269
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  6th International Charcot-Marie-Tooth and Related Neuropathy Consortium 
Meeting, CMTR 2016
CONFERENCE LOCATION
  Venice-Mestre, Italy
CONFERENCE DATE
  2016-09-08 to 2016-09-10
ISSN
  1529-8027
BOOK PUBLISHER
  Blackwell Publishing Inc.
ABSTRACT
  BICD2 has previously been reported as a rare cause of a distal-predominant 
spinal muscular atrophy (SMA). Here we report a case involving a De novo and 
novel mutation 2080C>T resulting in a more severe phenotype than has 
previously been reported. The patient was diagnosed antenatally with 
arthrogryposis congenital with normal fetal cardiac echocardiogram and brain 
MRI. She was born with severe arthrogryposis: flexion contractures of 
elbows, ulnar deviation at the wrist, bilateral flexion contractures of 
index fingers, severe hip flexion and knee extension contractures. She 
needed respiratory support with CPAP at birth. NCS/EMG done shortly after 
birth demonstrated unobtainable sensory responses. Motor responses in the 
lower extremities were absent and significantly decreased in amplitude with 
normal conduction velocity in the arm. EMG showed evidence of chronic 
denervation/reinnervation. Muscle biopsy demonstrated extensive fibrous and 
fatty tissue replacement of muscle with groups of tiny muscle fibers 
embedded in connective tissue, consistent with severe neurogenic atrophy. 
She continued to have significant respiratory requirements as well as 
difficulty handling secretions leading to tracheostomy. She has had gradual 
improvement since birth. By age of 21 months, she was able to reach her arms 
antigravity to grab for toys and bring hands to her mouth. She still had 
only minimal movement in her lower extremities. She had a few words, but 
with significant cognitive delay. She continues with tracheostomy, but 
primarily on CPAP while awake. This case has expanded the phenotype and 
genotype associated with BICD2 mutation.
EMTREE DRUG INDEX TERMS
  endogenous compound; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  genetic predisposition; mutation; phenotype; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  adipose tissue; arthrogryposis; bodily secretions; brain; case report; denervation; diagnosis; echocardiography; elbow; female; fetus; flexion contracture; gene frequency; genotype; gravity; hereditary motor sensory neuropathy; hip; human; index finger; infant; intellectual impairment; knee; mouth; muscle biopsy; nuclear magnetic resonance imaging; positive end expiratory pressure; reinnervation; skeletal muscle cell; tracheostomy; ulna; velocity; wakefulness; wrist; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L618026470
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15298027&id=doi:&atitle=A+severe+spinal+muscular+atrophy+phenotype+associated+with+a+novel+BICD2+mutation&stitle=J.+Peripher.+Nerv.+Syst.&title=Journal+of+the+Peripheral+Nervous+System&volume=21&issue=3&spage=269&epage=&aulast=Kichula&aufirst=E.A.&auinit=E.A.&aufull=Kichula+E.A.&coden=&isbn=&pages=269-&date=2016&auinit1=E&auinitm=A
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 257
TITLE
  Transverse Myelitis in Turner syndrome
AUTHOR NAMES
  Kopacek C.; Vieira S.; Capelo L.; Quadros F.; Kieling R.; Da Silva C.A.
AUTHOR ADDRESSES
  (Kopacek C.; Vieira S.; Capelo L.; Quadros F.; Kieling R.; Da Silva C.A.) 
Hospital da Criança Santo Antônio, Porto Alegre, Brazil.
(Vieira S.; Capelo L.; Kieling R.; Da Silva C.A.) Universidade De Ciências 
da Saude de Porto Alegre, Porto Alegre, Brazil.
CORRESPONDENCE ADDRESS
  C. Kopacek, Hospital da Criança Santo Antônio, Porto Alegre, Brazil.
FULL RECORD ENTRY DATE
  2017-05-09
SOURCE
  Hormone Research in Paediatrics (2016) 86 Supplement 1 (477). Date of 
Publication: 1 Sep 2016
VOLUME
  86
FIRST PAGE
  477
DATE OF PUBLICATION
  1 Sep 2016
CONFERENCE NAME
  55th Annual Meeting of the European Society for Paediatric Endocrinology, 
ESPE 2016
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2016-09-10 to 2016-09-12
ISSN
  1663-2826
BOOK PUBLISHER
  S. Karger AG
ABSTRACT
  Background: Transverse Myelitis (TM) is an auto-immune syndrome with neural 
injury to the spinal cord. The TM may be first clinical manifestation of 
Multiple Sclerosis (MS). It is known that Turner's Syndrome (TS) is 
associated to the presence of autoimmune diseases. Case Report: A 15-year 
old female, began with manifestations of loss of strength on the lower limbs 
evolving rapidly with sensorial loss, tetraparesis and hemodynamic 
instability, requiring intubation. Two days later she was transferred to the 
intensive care unit (ICU). The patient had hypothyroidism diagnosed at the 
age of 2 and TS at age of 11, and had been in use of Vitamin D and calcium 
carbonate, conjugated estrogen, progestogen, levothyroxine, oxandrolone and 
growth hormone. On examination, she had BMI 29.5, Glasgow 15, flaccid 
tetraplegia and areflexia. MRI showed extensive hypointense signs on T1 and 
T2 on the central region of the cervical spine. She was diagnosed with TM 
and received 7 cycles of plasmapheresis, pulse therapy with 
methylprednisolone for 5 days followed by Rituximab with partial improvement 
of the strength and weaning of vasoactive drugs and mechanical ventilation. 
She was discharged from the ICU 2 months after admission, tracheostomized 
and bedridden. One month later she was discharged with prednisolone and 
azathioprine. Conclusion: TS is associated to the presence of autoimmune 
diseases (AID), though its association with TM or MS has been rarely 
reported. Despite the strong association between TS and AID is well known, 
the underlying immunopathogenic mechanism remains unexplained. Recent 
studies have displayed that TS patients do not show an excess of immunogenic 
risk markers. This is evocative for a higher responsibility of X-chromosome 
abnormalities in the development of AID. Early diagnosis and regular 
screening for potential associated autoimmune conditions are essential in 
the medical follow-up of TS patients.
EMTREE DRUG INDEX TERMS
  azathioprine; calcium; calcium carbonate; conjugated estrogen; endogenous compound; gestagen; growth hormone; levothyroxine; methylprednisolone; oxandrolone; prednisolone; rituximab; vitamin D; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myelitis; Turner syndrome; 
EMTREE MEDICAL INDEX TERMS
  adolescent; areflexia; artificial ventilation; asthenia; autoimmune disease; body mass; case report; cervical spine; child; chromosome aberration; diagnosis; drug therapy; early diagnosis; female; follow up; hemodynamics; human; hypothyroidism; immobility; intensive care unit; intubation; lower limb; multiple sclerosis; nuclear magnetic resonance imaging; plasmapheresis; preschool child; quadriplegia; responsibility; school child; screening; weaning; 
CAS REGISTRY NUMBERS
  azathioprine (446-86-6)
  calcium (7440-70-2, 14092-94-5)
  calcium carbonate (13397-26-7, 13701-58-1, 14791-73-2, 471-34-1)
  growth hormone (36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6)
  levothyroxine (51-48-9)
  methylprednisolone (6923-42-8, 83-43-2)
  oxandrolone (53-39-4)
  prednisolone (50-24-8)
  rituximab (174722-31-7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L615915614
DOI
  10.1159/000449142
FULL TEXT LINK
  http://dx.doi.org/10.1159/000449142
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16632826&id=doi:10.1159%2F000449142&atitle=Transverse+Myelitis+in+Turner+syndrome&stitle=Horm.+Res.+Paediatr.&title=Hormone+Research+in+Paediatrics&volume=86&issue=&spage=477&epage=&aulast=Kopacek&aufirst=Cristiane&auinit=C.&aufull=Kopacek+C.&coden=&isbn=&pages=477-&date=2016&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 258
TITLE
  Postoperative management
AUTHOR NAMES
  Schraag S.
AUTHOR ADDRESSES
  (Schraag S., stefanschraag@btinternet.com) Department of Perioperative 
Medicine, Golden Jubilee National Hospital, Agamemnon Street, Clydebank, 
United Kingdom.
AiP/IP ENTRY DATE
  2016-10-17
FULL RECORD ENTRY DATE
  2016-10-31
SOURCE
  Best Practice and Research: Clinical Anaesthesiology (2016) 30:3 (381-393). 
Date of Publication: 1 Sep 2016
VOLUME
  30
ISSUE
  3
FIRST PAGE
  381
LAST PAGE
  393
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1532-169X (electronic)
  1521-6896
BOOK PUBLISHER
  Bailliere Tindall Ltd
ABSTRACT
  Most patients undergoing major aortic surgery have multiple comorbidities 
and are at high risk of postoperative complications that affect multiple 
organ systems. Different aortic pathologies and surgical repair techniques 
have specific impact on the postoperative course. Ischemia–reperfusion 
injury is the common denominator in aortic surgery and influences the 
integrity of end-organ function. Common postoperative problems include 
hemodynamic instability due to the immediate inflammatory response, renal 
impairment, spinal cord ischemia, respiratory failure with prolonged 
mechanical ventilation, and gastrointestinal symptoms such as ileus or 
mesenteric ischemia. Focused care bundles to establish homeostasis and a 
team working toward an early functional recovery determine the success of 
effective rehabilitation and outcomes after aortic surgery.
EMTREE DRUG INDEX TERMS
  glucose (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic surgery; intensive care; postoperative care; postoperative complication; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication); adult respiratory distress syndrome (complication); analgesia; artificial ventilation; aspiration pneumonia; bleeding (complication); blood clotting disorder (complication); body temperature monitoring; cerebrovascular accident (complication); checklist; chest infection (complication); chylothorax (complication); cognitive defect (complication); delirium (complication); fluid therapy; glucose blood level; heart arrhythmia; heart failure; heart muscle ischemia; heart tamponade (complication); hemodynamics; heparin induced thrombocytopenia (complication); human; hypertension; hypotension; intensive care unit; liver failure (complication); malabsorption (complication); mesenteric ischemia (complication); metabolic regulation; neurologic examination; pancreatitis (complication); pleura effusion (complication); pneumonia (complication); priority journal; prognosis; respiratory failure; review; spinal cord ischemia (complication); thoracotomy; tracheostomy; transfusion related acute lung injury (complication); treatment outcome; 
CAS REGISTRY NUMBERS
  glucose (50-99-7, 84778-64-3)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160728396
MEDLINE PMID
  27650347 (http://www.ncbi.nlm.nih.gov/pubmed/27650347)
PUI
  L612645945
DOI
  10.1016/j.bpa.2016.06.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.bpa.2016.06.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1532169X&id=doi:10.1016%2Fj.bpa.2016.06.001&atitle=Postoperative+management&stitle=Best+Pract.+Res.+Clin.+Anaesthesiol.&title=Best+Practice+and+Research%3A+Clinical+Anaesthesiology&volume=30&issue=3&spage=381&epage=393&aulast=Schraag&aufirst=Stefan&auinit=S.&aufull=Schraag+S.&coden=BPRCD&isbn=&pages=381-393&date=2016&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 259
TITLE
  Cardiac arrest due to pneumoperitoneum after PEG insertion in ALSpatient
ORIGINAL (NON-ENGLISH) TITLE
  ALS hastasında PEG takılması sonrası pnömoperitoneuma bağlı gelişen kardiyak 
arrest
AUTHOR NAMES
  Ceylan B.G.; Karabacak P.; Saygın H.; Demirel H.F.; Eroğlu F.
AUTHOR ADDRESSES
  (Ceylan B.G.; Karabacak P., drpinara@gmail.com; Saygın H.; Demirel H.F.; 
Eroğlu F.) Department of Anesthesiology and Reanimation, Suleyman Demirel 
University Faculty of Medicine, Isparta, Turkey.
CORRESPONDENCE ADDRESS
  P. Karabacak, Department of Anesthesiology and Reanimation, Suleyman Demirel 
University Faculty of Medicine, Isparta, Turkey. Email: drpinara@gmail.com
AiP/IP ENTRY DATE
  2016-08-30
FULL RECORD ENTRY DATE
  2016-09-02
SOURCE
  Journal of Clinical and Analytical Medicine (2016) 7:5 (743-745). Date of 
Publication: 1 Sep 2016
VOLUME
  7
ISSUE
  5
FIRST PAGE
  743
LAST PAGE
  745
DATE OF PUBLICATION
  1 Sep 2016
ISSN
  1309-2014 (electronic)
  1309-0720
BOOK PUBLISHER
  Journal of Clinical and Analytical Medicine, secretary@jcam.com.tr
ABSTRACT
  Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, 
is characterized by motor neuron degeneration in the primary cortex, 
brainstem, and spinal cord. Percutaneous endoscopic gastrostomy (PEG) is a 
preferable method of nutritional support in patients with normal 
gastrointestinal function who can-not be fed orally for various reasons. PEG 
tube placement is recommended in amyotrophic lateral sclerosis (ALS) 
patients with dysphagia to provide reliable access for medications and 
nutrition. We report a case of a 63-year-old man with amyotrophic lateral 
sclerosis presenting with dysphagia and pneumoperitoneum following 
percutaneous endoscopic gastrostomy (PEG) placement. We also report on the 
intensive care period of this patient. PEG is a widely used nutrition 
therapy in these cases but complications such as pneumoperitoneum result in 
long term ICU stays and higher mortality rates.
EMTREE DRUG INDEX TERMS
  piperacillin plus tazobactam (drug therapy); riluzole (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (drug therapy, drug therapy); heart arrest; percutaneous endoscopic gastrostomy; pneumoperitoneum (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  abdominal pain; adult; article; body weight loss; case report; computer assisted tomography; dysphagia; dyspnea; hoarseness; human; male; middle aged; muscle atrophy; nasogastric tube; necrotizing enterocolitis (diagnosis); nutritional status; pneumonia (drug therapy); reflex disorder; respiratory arrest; resuscitation; T tube; thorax radiography; tracheotomy; weakness; 
CAS REGISTRY NUMBERS
  riluzole (1744-22-5)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
  Gastroenterology (48)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, Turkish
EMBASE ACCESSION NUMBER
  20160615147
PUI
  L611807011
DOI
  10.4328/JCAM.4692
FULL TEXT LINK
  http://dx.doi.org/10.4328/JCAM.4692
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13092014&id=doi:10.4328%2FJCAM.4692&atitle=Cardiac+arrest+due+to+pneumoperitoneum+after+PEG+insertion+in+ALSpatient&stitle=J.+Clin.+Anal.+Med.&title=Journal+of+Clinical+and+Analytical+Medicine&volume=7&issue=5&spage=743&epage=745&aulast=Ceylan&aufirst=Berit+G%C3%B6k%C3%A7e&auinit=B.G.&aufull=Ceylan+B.G.&coden=&isbn=&pages=743-745&date=2016&auinit1=B&auinitm=G
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 260
TITLE
  W44X mutation in the WWOX gene causes intractable seizures and developmental 
delay: A case report
AUTHOR NAMES
  Elsaadany L.; El-Said M.; Ali R.; Kamel H.; Ben-Omran T.
AUTHOR ADDRESSES
  (Elsaadany L., loai.elsaadany@yahoo.com) Hamad Medical Corporation, 
Department of Pediatric, Doha, Qatar.
(El-Said M., fawzi59@gmail.com) Pediatric Neurology, Hamad Medical 
Corporation, Department of Pediatric, Doha, Qatar.
(Ali R., rehab76@hotmail.com; Ben-Omran T., tawben11@hotmail.com) Clinical 
and Metabolic Genetic, Hamad Medical Corporation, Department of Pediatric, 
Doha, Qatar.
(Kamel H., hakamel@hotmail.com) Hamad Medical Corporation, Department of 
Neuro-Radiology, Doha, Qatar.
(Ben-Omran T., tawben11@hotmail.com) Clinical Genetics, Weill-Cornell 
Medical College-Qatar, Clinical and Metabolic Genetic, Hamad Medical 
Corporation, Department of Pediatric, PO Box 3050, Doha, Qatar.
CORRESPONDENCE ADDRESS
  T. Ben-Omran, Clinical and Metabolic Genetic, Hamad Medical Corporation, 
Department of Pediatric, Doha, Qatar. Email: tawben11@hotmail.com
AiP/IP ENTRY DATE
  2016-08-12
FULL RECORD ENTRY DATE
  2016-08-23
SOURCE
  BMC Medical Genetics (2016) 17:1 Article Number: 53. Date of Publication: 5 
Aug 2016
VOLUME
  17
ISSUE
  1
DATE OF PUBLICATION
  5 Aug 2016
ISSN
  1471-2350 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Background: WW domain containing oxidoreductase (WWOX) gene was cloned in 
2000; alteration has been seen in many cancer cells. It acts as a tumor 
suppresser by blocking cell growth and causing apoptosis. WWOX protein 
showed different expression of mice brain and spinal cord, for which 
deletion causes seizure and early death. Case presentation: Clinical and 
molecular characteristics of a consanguineous family show a homozygous 
mutation of WWOX gene at specific bases, causing a debilitating syndrome 
characterized by growth retardation, intractable epilepsy, intellectual 
disability, and early death. Using Whole Exome Sequencing (WES), a novel 
homozygous mutation in the WWOX gene is identified in a consanguineous Arab 
family from Qatar with two daughters who presented with intractable seizure 
and developmental delay. Conclusion: The study presents the importance of 
human WWOX gene for brain development and the association between gene 
mutation and epileptic encephalopathy. It also highlights the power of WES 
particularly in clinically challenging cases.
EMTREE DRUG INDEX TERMS
  clobazam (drug therapy); clonazepam (drug therapy); genomic DNA (endogenous compound); levetiracetam (drug therapy); messenger RNA (endogenous compound); phenobarbital (drug therapy); phenytoin (drug therapy); topiramate (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  developmental disorder; gene mutation; intractable epilepsy (diagnosis, etiology); WWOX gene; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; article; artificial ventilation; aspiration; birth weight; brain atrophy (diagnosis); brain disease (diagnosis); bronchiolitis; case report; child; consanguineous marriage; demyelination (diagnosis); disease course; disease severity; electroencephalogram; epileptic discharge (diagnosis); exome; feeding difficulty; female; fever; frontal lobe; gastrointestinal symptom; gene; genetic variation; head circumference; hospital admission; human; hypersalivation; lack of drug effect; muscle contracture; muscle hypertonia; muscle strength; muscle weakness; myoclonus; nasogastric tube; neuroimaging; nuclear magnetic resonance imaging; pathogenesis; persistent vegetative state; positive end expiratory pressure; proximal humerus fracture; psychomotor retardation; respiratory failure; school child; scoliosis; seizure (drug therapy); sequence analysis; stomach tube; tachypnea; temporal lobe; tonic seizure (diagnosis); tracheostomy; treatment response; visual evoked potential; 
CAS REGISTRY NUMBERS
  clobazam (22316-47-8)
  clonazepam (1622-61-3)
  levetiracetam (102767-28-2)
  phenobarbital (50-06-6, 57-30-7, 8028-68-0)
  phenytoin (57-41-0, 630-93-3)
  topiramate (97240-79-4)
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Drug Literature Index (37)
  General Pathology and Pathological Anatomy (5)
  Epilepsy Abstracts (50)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160587777
MEDLINE PMID
  27495153 (http://www.ncbi.nlm.nih.gov/pubmed/27495153)
PUI
  L611553953
DOI
  10.1186/s12881-016-0317-z
FULL TEXT LINK
  http://dx.doi.org/10.1186/s12881-016-0317-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14712350&id=doi:10.1186%2Fs12881-016-0317-z&atitle=W44X+mutation+in+the+WWOX+gene+causes+intractable+seizures+and+developmental+delay%3A+A+case+report&stitle=BMC+Med.+Genet.&title=BMC+Medical+Genetics&volume=17&issue=1&spage=&epage=&aulast=Elsaadany&aufirst=Loai&auinit=L.&aufull=Elsaadany+L.&coden=BMGMA&isbn=&pages=-&date=2016&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 261
TITLE
  Neuropathologic and neurobiologic characterization of early onset 
amyotrophic lateral sclerosis associated with a novel TDP43 S375G variant
AUTHOR NAMES
  Newell K.; Ghetti B.; Murrell J.; Romano M.; Salis E.; Stuani C.; Buratti E.
AUTHOR ADDRESSES
  (Newell K.) University of Kansas, School of Medicine, Pathology and 
Laboratory Medicine, Kansas City, United States.
(Ghetti B.; Murrell J.) Indiana University, School of Medicine, Pathology 
and Laboratory Medicine, Indianapolis, United States.
(Romano M.; Salis E.; Stuani C.; Buratti E.) University of Trieste, 
International Centre for Genetic Engineering and Biotechnology, Trieste, 
Italy.
CORRESPONDENCE ADDRESS
  K. Newell, University of Kansas, School of Medicine, Pathology and 
Laboratory Medicine, Kansas City, United States.
FULL RECORD ENTRY DATE
  2016-09-01
SOURCE
  Journal of Neurochemistry (2016) 138 Supplement 1 (370). Date of 
Publication: 1 Aug 2016
VOLUME
  138
FIRST PAGE
  370
DATE OF PUBLICATION
  1 Aug 2016
CONFERENCE NAME
  10th International Conference on Frontotemporal Dementias
CONFERENCE LOCATION
  Munich, Germany
CONFERENCE DATE
  2016-08-31 to 2016-09-02
ISSN
  0022-3042
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with 
onset most frequently occurring in middle age. Familial ALS may have an 
earlier onset. A 22 year-old woman presented with painless weakness of the 
right foot and leg. An EMG showed denervation involving the muscles of the 
right lower extremity. Weakness progressed to the left lower extremity and 
subsequently to the upper extremities. The clinical diagnosis was ALS. By 
the age of 24, she used a wheelchair and required a tracheostomy. She died 
at age 26. A family history of ALS was reported in distant relatives. An 
autopsy was carried out, and the neuropathologic evaluation showed upper and 
lower motor neuron loss, corticospinal tract degeneration, and neurogenic 
changes in skeletal muscle. TDP43 and FUS-immunoreactive neuronal and glial 
inclusions were present in motor cortex, putamen, globus pallidus, thalamus, 
substantia nigra, inferior olivary nucleus, and anterior horns of the spinal 
cord. DNA was extracted from brain tissue, and a TDP43 S375G change was 
found. A C9ORF72 expansion was not identified. To determine whether the 
TDP43 variant is pathogenic, we have studied a recombinant protein carrying 
the S375G change via transfection in HeLa cells. Our results show that this 
variant does not appear to alter the predominantly nuclear localization of 
TDP43. However, the variant protein shows increased ability to induce CFTR 
exon 9 skipping in a minigene-based add-back splicing assay with respect to 
wild-type TDP43. This result suggests that the S375G substitution may act 
through a gain-of-function mechanism. We tested a nearby TDP43 mutation, 
N378D, previously identified in other patients, and found that it also 
caused a similar gain-of-function effect on the splicing ability of TDP43. 
Taken together, these results highlight the possible presence in the 
C-terminus of a novel region capable of affecting the splicing regulation 
function of TDP43.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  TAR DNA binding protein; 
EMTREE DRUG INDEX TERMS
  recombinant protein; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis; 
EMTREE MEDICAL INDEX TERMS
  adult; autopsy; brain tissue; case report; denervation; diagnosis; DNA structure; family study; female; foot; gene mutation; genetic transfection; globus pallidus; human; inferior olivary nucleus; motoneuron; motor cortex; putamen; pyramidal tract; RNA splicing; skeletal muscle; spinal cord ventral horn; substantia nigra; thalamus; tracheostomy; upper limb; weakness; wheelchair; wild type; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L611855920
DOI
  10.1111/jnc.13692
FULL TEXT LINK
  http://dx.doi.org/10.1111/jnc.13692
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223042&id=doi:10.1111%2Fjnc.13692&atitle=Neuropathologic+and+neurobiologic+characterization+of+early+onset+amyotrophic+lateral+sclerosis+associated+with+a+novel+TDP43+S375G+variant&stitle=J.+Neurochem.&title=Journal+of+Neurochemistry&volume=138&issue=&spage=370&epage=&aulast=Newell&aufirst=K.&auinit=K.&aufull=Newell+K.&coden=&isbn=&pages=370-&date=2016&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 262
TITLE
  A case report of acute injury in ankylosing spondylitis
AUTHOR NAMES
  Yeh Y.-H.; Su Y.-J.
AUTHOR ADDRESSES
  (Yeh Y.-H.) Department of Emergency Medicine, Taipei City Hospital, 
Zhongxing Branch, Taipei City, Taiwan.
(Su Y.-J., yjsu.5885@mmh.org.tw) Department of Emergency Medicine, Mackay 
Memorial Hospital, Taipei City, Taiwan.
(Su Y.-J., yjsu.5885@mmh.org.tw) Department of Oral Hygiene, College of Oral 
Medicine, Taipei Medical University, Taipei City, Taiwan.
(Su Y.-J., yjsu.5885@mmh.org.tw) Department of Emergency Medicine, Mackay 
Medical College, New Taipei City, Taiwan.
(Su Y.-J., yjsu.5885@mmh.org.tw) Mackay Junior College of Medicine, Nursing 
and Management, Taipei City, Taiwan.
CORRESPONDENCE ADDRESS
  Y.-J. Su, Department of Emergency Medicine, Mackay Memorial Hospital, New 
Taipei City, Taiwan. Email: yjsu.5885@mmh.org.tw
AiP/IP ENTRY DATE
  2016-07-15
FULL RECORD ENTRY DATE
  2016-11-17
SOURCE
  Journal of Acute Disease (2016) 5:4 (343-344). Date of Publication: 1 Jul 
2016
VOLUME
  5
ISSUE
  4
FIRST PAGE
  343
LAST PAGE
  344
DATE OF PUBLICATION
  1 Jul 2016
ISSN
  2221-6189
BOOK PUBLISHER
  Elsevier (Singapore) Pte Ltd, 3 Killiney Road, 08-01, Winsland House I, 
Singapore, Singapore.
ABSTRACT
  Ankylosing spinal disorders tend to fracture after minor trauma because of 
its changed biomechanical properties. Herein we presented an ankylosing 
spinal disorders case with cervical spine fracture in a trauma after neck 
protection and surgical airway application. On CT scan of cervical spine, 
ankylosing spondylitis with an extension C4–C5 fracture was found. The 
patients' family decided not to receive operation to immobilize his cervical 
spine, then he was admitted to our surgical intensive care unit. He was 
discharged against medical advice two months later with a permanent 
tracheostomy with ventilator dependence due to high-level spinal cord 
injury. Timely identification of unstable fractures is instrumental in 
avoiding adverse neurologic sequela.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis; 
EMTREE MEDICAL INDEX TERMS
  adult; article; blunt trauma; case report; cervical collar; cervical spine fracture; computer assisted tomography; dyspnea; fracture immobilization; human; hypoxia; lung ventilation; male; middle aged; motor vehicle; priority journal; quadriplegia; spinal cord injury; tracheostomy; tracheotomy; traffic accident; unconsciousness; ventilator; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160508451
PUI
  L611163515
DOI
  10.1016/j.joad.2015.10.006
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.joad.2015.10.006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22216189&id=doi:10.1016%2Fj.joad.2015.10.006&atitle=A+case+report+of+acute+injury+in+ankylosing+spondylitis&stitle=J.+Acute+Dis.&title=Journal+of+Acute+Disease&volume=5&issue=4&spage=343&epage=344&aulast=Yeh&aufirst=Yu-Hang&auinit=Y.-H.&aufull=Yeh+Y.-H.&coden=&isbn=&pages=343-344&date=2016&auinit1=Y&auinitm=-H
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 263
TITLE
  Tracheostomy following anterior cervical spine fusion in trauma patients
AUTHOR NAMES
  Binder H.; Lang N.; Tiefenboeck T.M.; Bukaty A.; Hajdu S.; Sarahrudi K.
AUTHOR ADDRESSES
  (Binder H., harald.binder@meduniwien.ac.at; Lang N., 
nikolaus.lang@meduniwien.ac.at; Tiefenboeck T.M., 
thomas.tiefenboeck@meduniwien.ac.at; Hajdu S., 
stefan.hajdu@meduniwien.ac.at; Sarahrudi K., 
kambiz.sarahrudi@meduniwien.ac.at) Department of Trauma Surgery, Medical 
University of Vienna, Waehringerguertel 18-20, Vienna, Austria.
(Bukaty A., adam.bukaty@meduniwien.ac.at) Division of General Anaesthesia 
and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria.
CORRESPONDENCE ADDRESS
  K. Sarahrudi, Department of Trauma Surgery, Medical University of Vienna, 
Waehringerguertel 18-20, Vienna, Austria. Email: 
kambiz.sarahrudi@meduniwien.ac.at
AiP/IP ENTRY DATE
  2015-07-27
FULL RECORD ENTRY DATE
  2016-07-08
SOURCE
  International Orthopaedics (2016) 40:6 (1157-1162). Date of Publication: 1 
Jun 2016
VOLUME
  40
ISSUE
  6
FIRST PAGE
  1157
LAST PAGE
  1162
DATE OF PUBLICATION
  1 Jun 2016
ISSN
  1432-5195 (electronic)
  0341-2695
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Purpose: Traumatic injuries to the cervical spine are frequently accompanied 
by cervical spinal cord injuries—often necessitating tracheostomy. The 
purpose of this study was to evaluate patient characteristics and outcomes 
after undergoing anterior cervical spine fusion (ACSF) with tracheostomy. 
Methods: All patients with cervical spine injury (CSI) who underwent ACSF 
and tracheostomy between December 1992 and June 2014 were included in this 
retrospective data analysis. The study group consisted of 32 men (84 %) and 
six women (16 %), with an average age of 47 ± 20 years. Blunt trauma to the 
cervical spine was the cause of CSI in all 38 patients. Results: The mean 
Injury Severity Score (ISS) was 30.50 ± 6.25. Eighteen patients sustained 
severe concomitant injuries related to the spinal injury. In 15 patients 
(39.5 %), traumatic brain injury (TBI) with fractures of the cranium and/or 
intracranial lesions were observed. The mean Glasgow Coma Scale (GCS) score 
was 11 ± 4.5 (range 3–15). Two tracheostomies (5.3 %) were performed 
simultaneously with ACSF. The remaining 36 were performed with an average 
“delay” of 15 ± ten days. We observed no difference in time to tracheostomy 
among patients initially presenting with an American Spinal Injury 
Association (ASIA) score of either A, B, C or D. Only two patients (5.3 %) 
were identified as having an infection at the site of ACSF after placement 
of a tracheostomy. There were no deaths directly related to airway 
difficulties in our cohort. Conclusions: Our data show that tracheostomy is 
safely performed after an average of 15 days post-ACSF, thereby being 
associated with a very low rate of complications. However, future 
prospective randomised studies are needed to identify the optimal timing of 
tracheostomy placement after ACSF. Level of evidence: IV; retrospective case 
series.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spine fusion; cervical spinal cord injury (surgery); cervical spine injury (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; adult respiratory distress syndrome; American Spinal Injury Association impairment scale; article; blunt trauma; brain damage; cervical spine; clinical article; female; follow up; Glasgow coma scale; hospital admission; hospitalization; human; infection rate; intensive care unit; limb fracture; male; middle aged; priority journal; retrospective study; skull fracture; surgical technique; thorax injury; traumatic brain injury; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015206800
MEDLINE PMID
  26194918 (http://www.ncbi.nlm.nih.gov/pubmed/26194918)
PUI
  L605254732
DOI
  10.1007/s00264-015-2913-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00264-015-2913-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14325195&id=doi:10.1007%2Fs00264-015-2913-5&atitle=Tracheostomy+following+anterior+cervical+spine+fusion+in+trauma+patients&stitle=Int.+Orthop.&title=International+Orthopaedics&volume=40&issue=6&spage=1157&epage=1162&aulast=Binder&aufirst=Harald&auinit=H.&aufull=Binder+H.&coden=IORTD&isbn=&pages=1157-1162&date=2016&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 264
TITLE
  Needs assessment of adults post-intensive care rehabilitation department in 
Amiens university hospital
AUTHOR NAMES
  Bacari-Risal G.; Doutrellot P.L.; Vaysse B.; Inan M.; Khelfoun K.; Nasserallah M.; Maizel J.; Legrand-Monteil C.; Tasseel-Ponche S.
AUTHOR ADDRESSES
  (Bacari-Risal G.) Med. Physi. Readaptation Plateau Tech. et Unite Mobile De 
Mpr Et Reanimation Med., Centre Hospitalier Universitaire, Amiens, France.
(Doutrellot P.L.; Tasseel-Ponche S.) Medecine Physique Et Readaptation 
Neurologique Et Ufr De Medecine Upjv, Pole Sante, Centre Hospitalier 
Universitaire, Amiens, France.
(Vaysse B.) Service D'Information Médicale, Service D'Épidémiologie, Centre 
Hospitalier Universitaire, Amiens, France.
(Inan M.) Soins Service, Service D'Hospitalisation à Domicile, Rivery, 
France.
(Khelfoun K.) Service Des Urgences, C.H. Compiègne-Noyon, Compiègne, France.
(Nasserallah M.) Département De Médecine Générale, Centre Hospitalier 
Universitaire, Amiens, France.
(Maizel J., maizel.julien@chu-amiens.fr) Réanimation Médicale, Centre 
Hospitalier Universitaire, Amiens, France.
(Legrand-Monteil C.) Médecine Physique Et Réadaptation Plateau Technique Et 
Unité Mobile De Mpr, Centre Hospitalier Universitaire, Amiens, France.
CORRESPONDENCE ADDRESS
  J. Maizel, Réanimation Médicale, Centre Hospitalier Universitaire, Amiens, 
France. Email: maizel.julien@chu-amiens.fr
FULL RECORD ENTRY DATE
  2016-07-23
SOURCE
  Annals of Intensive Care (2016) 6 SUPPL. 1. Date of Publication: June 2016
VOLUME
  6
DATE OF PUBLICATION
  June 2016
CONFERENCE NAME
  French Intensive Care Society, International Congress - Reanimation 2016
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2016-01-13 to 2016-01-15
ISSN
  2110-5820
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction A part of patients transferred from intensive care unit (ICU) 
to continuing care services is due to the persistence of important 
functional failures. The role of early rehabilitation in the management of 
these patients has shown interest. The creation of unit, with both expertise 
of intensivists and physics Doctor, would improve the healthcare network. 
But physical and rehabilitation medicine requires specialized human 
resources and equipment. This retrospective epidemiological pilot study was 
to determine the needs of Amiens University Hospital in post-intensive care 
rehabilitation department (PICRD). Patients and methods We determined the 
number of patients eligible to PICRD, during 2013. The Programme Médicalisé 
des Systèmes d'Information allowed to count all patients admitted to 
medical-surgical ICUs in Amiens University Hospital. Patients who had brain 
injury, spinal cord injury, or severe peripheral neurological damage 
regardless of origin were included in the study among the ICU patients. Even 
if they did not suffer from those pathologies, patients with duration of 
hospitalization (DH) over 7 days in the ICU were also included. The need for 
PICRD has been evaluated by computing the number of eligible patients in 
PICRD. They were eligible to PICRD: patients with persistent neurological 
impairment in their day 10 of hospitalization, without hemodynamic 
disability in absence of catecholamine, with a tracheotomy when a ventilator 
weaning was impossible. It was applied to the group “eligible” a new release 
date, which corresponded to day 2 after the realization of tracheotomy 
and/or stopping of catecholamine, and/or stopping continuous invasive 
treatments. This allowed calculating a new DH and therefore a new average 
length of stay. Over 70 and under 18 years old and those with undergoing 
neoplasia were excluded from the study. Results A total of 2690 
hospitalizations in ICU were counted at the Amiens University Hospital in 
2013. Seven hundred and seventeen patients were included in the study; after 
application of the exclusion criteria, a total of 388 were analyzed. This 
group of patients consisted of 72 % men, and the median age was 54 years old 
(IQR = 20.25). The median SAPS II was 42 (IQR = 28) with a median length of 
stay of 12 days (IQR = 14) and a mortality rate of 19.6 %. As regards the 
reasons for hospitalization: over half, 56 %, fell to neurological 
impairment, with stroke (25 %), severe traumatic brain injury (STBI = 22 %) 
and spinal cord injury (SCI = 6 %). The other half consisted mostly shocks 
(19 %), acute respiratory failure (8 %), acute respiratory distress syndrome 
(ARDS = 4.5 %), severe sepsis (5 %), cardiopulmonary arrest (2.5 %). Nearly 
22 % of patients (n = 84) were eligible for PICRD. They were young: median 
of age 55 years old (IQR = 20), mostly men (81 %). The median SAPS II was 38 
(IQR = 23.25). The main diseases were also neurological for 46 % with: 
stroke, STBI and SCI. Other causes were: shock for 14 %, acute respiratory 
distress and ARDS for a total of 28 %, severe sepsis for 11 %. Seventy-seven 
of them came out alive from the ICU, 20 % in intensive care in “Berck”, 10 % 
in physical and rehabilitation medicine unit, 50 % in medicine or surgery 
services. After application of the new date of stay, a significant 
difference in hospital stay of 40 days (p < 0.0001) was demonstrated. 
Conclusion There is a need of adults PICRD at Amiens University Hospital. It 
would allow an early medical and rehabilitative treatment, improving the 
fluidity of the post-intensive care discharge, and lead to a reduction in 
socioeconomic costs of care of these patients who need no more ICU care.
EMTREE DRUG INDEX TERMS
  catecholamine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult; intensive care; needs assessment; rehabilitation center; resuscitation; society; university hospital; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; adult respiratory distress syndrome; artificial ventilation; brain injury; cardiopulmonary arrest; cerebrovascular accident; disability; diseases; health care; hospitalization; human; intensive care unit; intensivist; invasive procedure; length of stay; male; mortality; neoplasm; pathology; patient; physician; physics; pilot study; rehabilitation; rehabilitation medicine; respiratory distress; sepsis; Simplified Acute Physiology Score; spinal cord injury; surgery; tracheotomy; traumatic brain injury; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72342772
DOI
  10.1186/s13613-016-0114-z
FULL TEXT LINK
  http://dx.doi.org/10.1186/s13613-016-0114-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21105820&id=doi:10.1186%2Fs13613-016-0114-z&atitle=Needs+assessment+of+adults+post-intensive+care+rehabilitation+department+in+Amiens+university+hospital&stitle=Ann.+Intensive+Care&title=Annals+of+Intensive+Care&volume=6&issue=&spage=&epage=&aulast=Bacari-Risal&aufirst=Gaelle&auinit=G.&aufull=Bacari-Risal+G.&coden=&isbn=&pages=-&date=2016&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 265
TITLE
  Osteopathia striata with cranial sclerosis (OSCS): review of the literature 
and case report demonstrating challenges of spinal fusion after trauma
AUTHOR NAMES
  Katsevman G.A.; Turner R.C.; Lucke-Wold B.P.; Sedney C.L.; Bhatia S.
AUTHOR ADDRESSES
  (Katsevman G.A.; Turner R.C.; Lucke-Wold B.P.; Sedney C.L.; Bhatia S., 
sbhatia@hsc.wvu.edu) Department of Neurosurgery, West Virginia University 
School of Medicine, One Medical Center Drive Suite 4300, Morgantown, United 
States.
(Katsevman G.A.; Turner R.C.; Lucke-Wold B.P.; Sedney C.L.; Bhatia S., 
sbhatia@hsc.wvu.edu) Center for Neuroscience, West Virginia University 
School of Medicine, Morgantown, United States.
CORRESPONDENCE ADDRESS
  S. Bhatia, Department of Neurosurgery, West Virginia University School of 
Medicine, One Medical Center Drive Suite 4300, Morgantown, United States. 
Email: sbhatia@hsc.wvu.edu
AiP/IP ENTRY DATE
  2016-04-19
FULL RECORD ENTRY DATE
  2016-08-11
SOURCE
  Acta Neurochirurgica (2016) 158:6 (1115-1120). Date of Publication: 1 Jun 
2016
VOLUME
  158
ISSUE
  6
FIRST PAGE
  1115
LAST PAGE
  1120
DATE OF PUBLICATION
  1 Jun 2016
ISSN
  0942-0940 (electronic)
  0001-6268
BOOK PUBLISHER
  Springer-Verlag Wien, michaela.bolli@springer.at
ABSTRACT
  Osteopathia striata with cranial sclerosis (OSCS) is a rare but 
well-described pathology characterized by abnormalities in bone deposition 
in the axial and cranial skeleton as well as other abnormalities and 
associated deficits. These skeletal abnormalities can lead to significant 
intra-operative challenges for the surgeon and influence outcomes for the 
patient. In this report, we present a case of a patient with OSCS who was 
involved in a traumatic motor vehicle crash and underwent posterior 
cervico-thoracic fusion for a T4 chance fracture. Bony abnormalities in the 
cervico-thoracic spine presented a significant operative challenge due to 
alterations in bony anatomy and bone architecture. This case serves as an 
example of the challenges that the spine surgeon faces when dealing with 
OSCS, and highlights the differences between OSCS and commoner skeletal 
hyperplasias such as osteopetrosis.
EMTREE DRUG INDEX TERMS
  suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone malformation (diagnosis); cervico thoracic fusion; osteopathia striata with cranial sclerosis (diagnosis); osteosclerosis (diagnosis); spine fusion; 
EMTREE MEDICAL INDEX TERMS
  acute disease; adult; Albers Schoenberg disease; arachnoid cyst; article; bone microarchitecture; brain cyst; brain ventricle dilatation; case report; chondrodysplasia; cleft palate; computer assisted tomography; corpus callosum; corpus callosum agenesis; crush trauma; diffuse axonal injury; fasciotomy; female; femur subtrochanteric fracture; frontal bossing; Glasgow coma scale; hospitalization; human; hyperlipidemia; hypothyroidism; lung contusion; medial collateral ligament; medical history; mental health; middle aged; motor vehicle; nuclear magnetic resonance imaging; optic nerve; optic nerve disease; optic nerve impingement; percutaneous endoscopic gastrostomy; posterior fossa; postoperative period; priority journal; rib fracture; spine radiography; stomach tube; subarachnoid hemorrhage; thoracic spine; tracheostomy; traumatic brain injury; 
CAS REGISTRY NUMBERS
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Human Genetics (22)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160293961
MEDLINE PMID
  27068044 (http://www.ncbi.nlm.nih.gov/pubmed/27068044)
PUI
  L609833051
DOI
  10.1007/s00701-016-2794-4
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00701-016-2794-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09420940&id=doi:10.1007%2Fs00701-016-2794-4&atitle=Osteopathia+striata+with+cranial+sclerosis+%28OSCS%29%3A+review+of+the+literature+and+case+report+demonstrating+challenges+of+spinal+fusion+after+trauma&stitle=Acta+Neurochir.&title=Acta+Neurochirurgica&volume=158&issue=6&spage=1115&epage=1120&aulast=Katsevman&aufirst=Gennadiy+A.&auinit=G.A.&aufull=Katsevman+G.A.&coden=ACNUA&isbn=&pages=1115-1120&date=2016&auinit1=G&auinitm=A
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 266
TITLE
  Postoperative extradural hematoma of the cervical spine: A rare but 
avoidable complication
AUTHOR NAMES
  Tomar G.S.; Kumar S.; Dube S.K.; Goyal K.
AUTHOR ADDRESSES
  (Tomar G.S., spunkygst@gmail.com; Kumar S., drshail.kumar@gmail.com; Dube 
S.K., drskdube@gmail.com; Goyal K., keshavgoyalster@gmail.com) Department of 
Neuroanaesthesiology and Critical Care, Neuroscience Centre, AIIMS, New 
Delhi, India.
CORRESPONDENCE ADDRESS
  G.S. Tomar, Department of Neuroanaesthesiology and Critical Care, 
Neuroscience Centre, AIIMS, New Delhi, India. Email: spunkygst@gmail.com
AiP/IP ENTRY DATE
  2016-04-21
FULL RECORD ENTRY DATE
  2016-05-05
SOURCE
  Journal of Clinical Anesthesia (2016) 31 (120-121). Date of Publication: 1 
Jun 2016
VOLUME
  31
FIRST PAGE
  120
LAST PAGE
  121
DATE OF PUBLICATION
  1 Jun 2016
ISSN
  1873-4529 (electronic)
  0952-8180
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
EMTREE DRUG INDEX TERMS
  anesthetic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidural hematoma (complication); postoperative complication (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; bleeding; breathing exercise; case report; cervical spine injury; comorbidity; emergency surgery; erythrocyte concentrate; erythrocyte transfusion; human; iatrogenic disease; immobility; incidence; intensive care unit; intubation; letter; male; massage; middle aged; nuclear magnetic resonance imaging; priority journal; reoperation; spinal cord compression; spine surgery; tracheobronchial toilet; tracheostomy; Valsalva maneuver; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160302034
MEDLINE PMID
  27185692 (http://www.ncbi.nlm.nih.gov/pubmed/27185692)
PUI
  L609738853
DOI
  10.1016/j.jclinane.2016.02.019
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jclinane.2016.02.019
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18734529&id=doi:10.1016%2Fj.jclinane.2016.02.019&atitle=Postoperative+extradural+hematoma+of+the+cervical+spine%3A+A+rare+but+avoidable+complication&stitle=J.+Clin.+Anesth.&title=Journal+of+Clinical+Anesthesia&volume=31&issue=&spage=120&epage=121&aulast=Tomar&aufirst=Gaurav+Singh&auinit=G.S.&aufull=Tomar+G.S.&coden=JCLBE&isbn=&pages=120-121&date=2016&auinit1=G&auinitm=S
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 267
TITLE
  Nothing will keep me down: A case of descending weakness in a patient with a 
pure motor guillain-barre syndrome variant
AUTHOR NAMES
  Leung P.
AUTHOR ADDRESSES
  (Leung P.) Weill Cornell/ New York Presbyterian, New York City, United 
States.
CORRESPONDENCE ADDRESS
  P. Leung, Weill Cornell/ New York Presbyterian, New York City, United 
States.
FULL RECORD ENTRY DATE
  2016-05-31
SOURCE
  Journal of General Internal Medicine (2016) 31:2 SUPPL. 1 (S691-S692). Date 
of Publication: May 2016
VOLUME
  31
ISSUE
  2
FIRST PAGE
  S691
LAST PAGE
  S692
DATE OF PUBLICATION
  May 2016
CONFERENCE NAME
  39th Annual Meeting of the Society of General Internal Medicine, SGIM 2016
CONFERENCE LOCATION
  Hollywood, FL, United States
CONFERENCE DATE
  2016-05-11 to 2016-05-14
ISSN
  1525-1497
BOOK PUBLISHER
  Springer New York LLC
ABSTRACT
  LEARNING OBJECTIVE #1: To recognize the presentation of a motor variant of 
Guillain-Barre Syndrome with atypical features LEARNING OBJECTIVE #2: To 
manage a patient with an acute motor axonal neuropathy CASE: 66 year old 
woman with no significant past medical history presents with descending 
weakness and pain. Four days prior to admission, she developed bilateral 
proximal upper extremity dull, aching pain followed by difficulty raising 
her arms above her head. She went to an emergency department and was 
discharged with pain medicines. Two days prior to presentation, she had 
difficulty ambulating due to lower extremity weakness and pain. On arrival, 
she was unable to stand. She denied any confusion, vision changes, jaw pain, 
chest pain, shortness of breath, abdominal pain, bowel/bladder incontinence, 
or other sensation changes. One week prior to hospitalization, she hiked 
effortlessly on a well-paved trail in the Mid-Atlantic and did not recall 
any bug bites. She also described a brief diarrheal illness around the same 
time. She denied recent travel, recent influenza vaccination, ingestion of 
canned foods, infected wounds, and history of intravenous drug use. Her 
physical exam is notable for pain with any movement of her arms and legs. 
Her muscles are tender on palpation. No rashes are appreciated. Her speech 
is intact. She has intact cranial nerves. She has 3/5 strength at bilateral 
deltoids and hips, 4/5 at bilateral wrists and knees, and 5/5 with 
dorsiflexion and plantarflexion. She is intact to light touch and 
hypo-reflexive throughout. She had down-going toes. Her CBC, BMP, and 
creatine kinase were all within normal limits. MRI brain did not reveal any 
acute intracranial pathology. MRI cervical spine only showed C3-C4 disc 
protrusion without spinal cord impingement. Lumbar puncture showed 1 wbc, 1 
rbc, negative gram stain, glucose 55, and protein 69, consistent with 
cytoalbuminologic dissociation. Her negative inspiratory force (NIF) was at 
-30. Given rapid progression in symptoms and picture most consistent with 
Guillian-Barre Syndrome (GBS), plasma exchange (PLEX) was initiated. 
Electromyography (EMG) was consistent with pure motor axonal GBS. She was 
also ganglioside antibody positive. Infectious work up was largely negative. 
Despite receiving plasma exchanges, her NIF progressively worsened to -18 
and she was intubated for airway protection. Subsequently, she was given 
intravenous immunoglobulin (IVIG) and later required a tracheostomy. Repeat 
EMG 1 month after admission showed minimal improvement in motor function. 
Ultimately, she was discharged to acute rehabilitation. DISCUSSION: GBS is 
an immune-mediated polyradiculoneuropathy with a mean age of onset of over 
40 and with a male predominance. Worldwide incidence of GBS is quoted at 0.6 
to 4/100,000 people. Typically, GBS presents with hyporeflexia and 
neuropathic pain in a symmetric ascending pattern. Our patient's descending 
presentation (less commonly seen in GBS) led us to consider botulism. 
However, this idea was quickly dismissed given lack of typical exposures to 
botulinum toxin. Her notable proximal muscles weakness also triggered 
concerns over possible acute myopathy/myositis. However with such a quick 
onset and a normal creatine kinase, the likelihood was low. This patient's 
clinical pattern is most consistent with acute motor axonal neuropathy 
(AMAN), a pure motor axonal subtype of GBS rarely seen in North America (3-5 
% of all GBS cases in North America). It is frequently associated with 
Campylobacter jejuni enteritis and the molecular mimicry of human 
gangliosides by C. jejuni lipo-oligosaccharides. Compared to the most common 
GBS subtype, acute inflammatory demyelinating polyradiculopathy (AIDP), AMAN 
typically has preserved reflexes (unlike this patient), less cranial nerve 
involvement, less autonomic dysfunction, and a more rapid progression of 
disease. Interestingly, despite having a pure motor GBS, this patient had 
significant pain on arrival. Unlike typical neuropathic pain that results 
from the degeneration of sensory nerve fibers as seen in AIDP, the pain she 
experienced in the acute phase of her disease was likely of nociceptive 
origin secondary to inflammation or inflammatory mediators. Another notable 
difference between more common forms of GBS is that recovery from axonal 
degradation (as in AMAN) takes longer than recovery from demyelination (as 
in AIDP). Regaining the ability to walk, if possible, may range from months 
to years. Supportive care plays a large role in AMAN as roughly 30% of GBS 
cases progress to respiratory failure. Frequent telemetry and respiratory 
monitoring is critical. PLEX (to remove autoantibodies, immune complexes, 
and other inflammatory mediators) and IVIG (to inhibit costimulatory 
molecules involved in antigen presentation and attenuate 
autoantibody-initiated inflammation) had both been shown in large randomized 
control trials to be effective therapies. However, patients in these studies 
were predominantly diagnosed with AIDP rather than AMAN. It is debated 
whether combined PLEX and IVIG (which our patient received) offer improved 
outcomes over monotherapy with PLEX or IVIG. Corticosteroids have no role in 
the treatment of GBS. Despite usage of these immunemodulating treatments, 
approximately 20 % of patients are left with severe disability.
EMTREE DRUG INDEX TERMS
  autoantibody; botulinum toxin; corticosteroid; creatine kinase; ganglioside; ganglioside antibody; glucose; immunoglobulin; oligosaccharide; protein; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Guillain Barre syndrome; human; internal medicine; patient; society; weakness; 
EMTREE MEDICAL INDEX TERMS
  abdominal pain; acute motor axonal neuropathy; airway; antigen antibody complex; antigen presentation; arm; autonomic dysfunction; botulism; brain; Campylobacter enteritis; canned food; cervical spine; cranial nerve; degeneration; demyelination; disability; diseases; dissociation; drug use; dyspnea; electromyogram; electromyography; emergency ward; exposure; female; Gram staining; hip; hospitalization; hyporeflexia; incontinence; inflammation; influenza vaccination; ingestion; jaw pain; knee; leg; leukocyte; lumbar puncture; male; medical history; molecular mimicry; monitoring; monotherapy; motor performance; muscle; nerve fiber; neuropathic pain; North America; nuclear magnetic resonance imaging; onset age; pain; palpation; pathology; plasmapheresis; polyradiculoneuropathy; protection; radiculopathy; rash; recall; reflex; rehabilitation; respiratory failure; sensation; sensory nerve; speech; spinal cord; telemetry; therapy; thorax pain; toe; tracheostomy; travel; wound; wrist; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72289267
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15251497&id=doi:&atitle=Nothing+will+keep+me+down%3A+A+case+of+descending+weakness+in+a+patient+with+a+pure+motor+guillain-barre+syndrome+variant&stitle=J.+Gen.+Intern.+Med.&title=Journal+of+General+Internal+Medicine&volume=31&issue=2&spage=S691&epage=S692&aulast=Leung&aufirst=Peggy&auinit=P.&aufull=Leung+P.&coden=&isbn=&pages=S691-S692&date=2016&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 268
TITLE
  The incidence of airway complications following posterior occipitocervical 
spine fusion
AUTHOR NAMES
  Sheshadri V.; Moga R.; Manninen P.; Venkatraghavan L.
AUTHOR ADDRESSES
  (Sheshadri V.; Moga R.; Manninen P.; Venkatraghavan L.) Anesthesiology, 
Toronto Western Hospital, University of Toronto, Toronto, Canada.
CORRESPONDENCE ADDRESS
  V. Sheshadri, Anesthesiology, Toronto Western Hospital, University of 
Toronto, Toronto, Canada.
FULL RECORD ENTRY DATE
  2016-12-12
SOURCE
  Anesthesia and Analgesia (2016) 122:5 Supplement 3 (S436). Date of 
Publication: 1 May 2016
VOLUME
  122
ISSUE
  5
FIRST PAGE
  S436
DATE OF PUBLICATION
  1 May 2016
CONFERENCE NAME
  2016 Annual Meeting of the International Anesthesia Research Society, IARS 
2016
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2016-03-21 to 2016-03-24
ISSN
  1526-7598
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  INTRODUCTION: The management of the airway may be challenging in patients 
undergoing occipitocervical spine fusions (OCF). Limited information is 
available regarding the incidence, severity, the mechanism, and the risk 
factors for postoperative airway complications after OCF. Changes in the 
occipitocervical angle (dOC2A) of fusion after surgery may result in acute 
airway obstruction, dyspnea and/or dysphagia.(1,2) The aim of this study was 
to determine the incidence, nature, and risk factors for postoperative 
airway complications in patients undergoing OCF and to determine the 
relationship between the dOC2A and airway complications. METHODS: After IRB 
approval, we retrospectively reviewed the charts of all patients who 
underwent OCF from 2005-2013. We excluded patients who had combined 
anterior/posterior or revision surgeries and those already intubated or with 
tracheostomy. Data collected included patient demographics, airway 
management, anesthesia and surgical data, and postoperative complications. 
Plain lateral radiographs or computed tomography were used to measure the 
dOC2A (Figure 1). Immediate postoperative airway complications included in 
the analysis were the need for reintubation and the delay of extubation in 
the operating room. Delayed complications were tracheostomy, pneumonia and 
mortality. Statistical analyses were done using unpaired t test, 
Mann-Whitney U test, Chi-square test and Fisher's exact test, as 
appropriate. P-value of <0.05 was considered significant. RESULTS: Records 
of 59 patients were reviewed. Demographic data are shown in Table 1. Common 
indications for surgery included degenerative, rheumatoid arthritis, 
metastases and fracture. Following extubation in the operating room (OR), 
there were no complications in 43 (73%) patients (Group 1). Airway 
complications were seen in 16 (27%) patients (Group 2); 4 patients required 
re intubation (2 in the OR, 2 in post anesthetic care unit), and 12 had 
delayed extubation and were taken to the intensive care unit intubated. The 
number of vertebral levels fused, presence of difficult intubation and 
duration of surgery were significantly associated with airway complications. 
There was no significant difference in the dOC2A between the groups 
(-1.070±5.527 versus -4.375±10.788, p=0.127) (Table 2). CONCLUSIONS: Airway 
management in patients undergoing OCF poses a challenge for 
anesthesiologists. The incidence of airway complications was 27%. The 
decision to extubate needs to be individualized, and factors such as 
difficult intubation, number of vertebral levels fused and the duration of 
the surgery has to be considered. We could not find a significant 
correlation between dOC2A and postoperative airway complications. The risk 
factors for postoperative airway complications are multifactorial and there 
is a need for prospective study to identify the risk factors.
EMTREE DRUG INDEX TERMS
  endogenous compound; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; anesthesist; chi square test; complication; computer assisted tomography; demography; dysphagia; dyspnea; extubation; fracture; human; information processing; intensive care unit; intubation; major clinical study; metastasis; mortality; operating room; pneumonia; postoperative complication; prospective study; rank sum test; respiration control; rheumatoid arthritis; risk factor; statistical significance; Student t test; surgery; tracheostomy; vertebra; X ray film; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L613553102
DOI
  10.1213/01.ane.0000499505.96779.a0
FULL TEXT LINK
  http://dx.doi.org/10.1213/01.ane.0000499505.96779.a0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15267598&id=doi:10.1213%2F01.ane.0000499505.96779.a0&atitle=The+incidence+of+airway+complications+following+posterior+occipitocervical+spine+fusion&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=122&issue=5&spage=S436&epage=&aulast=Sheshadri&aufirst=V.&auinit=V.&aufull=Sheshadri+V.&coden=&isbn=&pages=S436-&date=2016&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 269
TITLE
  The ugly truth of sagliker syndrome
AUTHOR NAMES
  Shepherd K.J.; Barker B.R.
AUTHOR ADDRESSES
  (Shepherd K.J.) UT Southwestern, Dallas, United States.
(Barker B.R.) UT Southwestern Medical Center at Dallas, Dallas, United 
States.
CORRESPONDENCE ADDRESS
  K.J. Shepherd, UT Southwestern, Dallas, United States.
FULL RECORD ENTRY DATE
  2016-05-31
SOURCE
  Journal of General Internal Medicine (2016) 31:2 SUPPL. 1 (S759). Date of 
Publication: May 2016
VOLUME
  31
ISSUE
  2
FIRST PAGE
  S759
DATE OF PUBLICATION
  May 2016
CONFERENCE NAME
  39th Annual Meeting of the Society of General Internal Medicine, SGIM 2016
CONFERENCE LOCATION
  Hollywood, FL, United States
CONFERENCE DATE
  2016-05-11 to 2016-05-14
ISSN
  1525-1497
BOOK PUBLISHER
  Springer New York LLC
ABSTRACT
  LEARNING OBJECTIVE #1: Recognize the clinical features of Sagliker Syndrome 
(SS). LEARNING OBJECTIVE #2: Recognize the importance of early diagnosis and 
treatment of ESRD to slow the progression of SS. CASE: A 23-year-old female 
with history of end stage renal disease (ESRD) of unknown etiology on 
emergent dialysis since the age of 18, secondary hyperparathyroidism, 
seizures, chronic respiratory failure with a tracheostomy was admitted to 
the ICU for pneumonia, requiring ventilator support and continuous renal 
replacement therapy. Her exam was particularly notable for short stature 
with height of 3 ft and a very thin and distorted trunk and extremities due 
to frequent fractures. She was wheelchair bound and unable to ambulate. Her 
head comprised approximately 1/3 of her body mass with severe maxillary and 
mandibular bony enlargement. Her oral exam revealed extensive tooth loss and 
bleeding gums. Her appearance was distinctly different from pictures her 
family shared from just 3 years prior. In addition, her lab values showed 
substantial abnormalities including PTH >5000 pg/mL, calcium 7 mg/dL; 
phosphorous 2 mg/dL, vitamin D-25-OH 9.8 ng/dL, and alkaline phosphatase 827 
units/L. This pattern of physical exam findings and extreme abnormalities 
was felt consistent with the unusual disorder, Sagliker Syndrome. Her 
secondary hyperparathyroidism was refractory to optimal medical management, 
and her hospital course was further complicated by endocarditis, right 
atrial thrombus, and inability to be weaned off of the ventilator. After 
nearly 90 days in the hospital, she developed acute neurologic changes, and 
CT head showed massive frontal lobe hemorrhage. The family ultimately 
decided to withdraw care. DISCUSSION: Yahya Sagliker, M.D. described 
Sagliker Syndrome (SS) in 2004. By 2012, only 60 cases had been recognized, 
however, Sagliker estimates the observed incidence to be near 0.5 %. 
Sagliker described this special population of patients with ESRD with an 
“uglifying” facial appearance, short stature, severe maxillary and 
mandibular changes, finger abnormalities, dental abnormalities, soft tissue 
tumors of the mouth, and neurologic and psychiatric symptoms. These patients 
are most often children who had a delay in treatment of renal insufficiency 
and are most frequently seen in underdeveloped countries. It has also seen 
in adults related to a severe form of renal osteodystrophy with parathyroid 
hyperplasia leading to lab abnormalities, as seen in our patient. These 
patients suffer from severe peripheral and central nervous system 
complications from the chaotic bone growth, including spinal cord 
compression, deafness, blindness, cortical deficits, as well as respiratory 
failure due to thoracic bone involvement. Vascular and neurologic impairment 
are the leading causes of death. While there is no treatment and it is 
unclear why certain patients develop this syndrome, a small study concluded 
that SS should be added to indications for total parathyroidectomy as this 
treatment has improved psychiatric symptoms and lab abnormalities. However, 
it could not reverse the skeletal malformations. Ultimately, there is no 
treatment beyond slowing the progression of the disease with optimal medical 
management.
EMTREE DRUG INDEX TERMS
  alkaline phosphatase; calcium; fenticlor; parathyroid hormone; vitamin D; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  internal medicine; society; 
EMTREE MEDICAL INDEX TERMS
  adult; bleeding; body mass; bone; bone growth; central nervous system; cerebral blindness; child; chronic respiratory failure; clinical feature; continuous renal replacement therapy; death; developing country; dialysis; disease management; diseases; early diagnosis; end stage renal disease; endocarditis; etiology; facies; female; fracture; frontal lobe; hearing impairment; heart atrium thrombosis; height; hospital; human; kidney failure; limited mobility; maxilla; mental disease; parathyroid hyperplasia; parathyroidectomy; patient; periodontal disease; pneumonia; population; renal osteodystrophy; respiratory failure; secondary hyperparathyroidism; seizure; short stature; skeleton malformation; soft tissue tumor; spinal cord compression; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72289402
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15251497&id=doi:&atitle=The+ugly+truth+of+sagliker+syndrome&stitle=J.+Gen.+Intern.+Med.&title=Journal+of+General+Internal+Medicine&volume=31&issue=2&spage=S759&epage=&aulast=Shepherd&aufirst=Kaylee+J.&auinit=K.J.&aufull=Shepherd+K.J.&coden=&isbn=&pages=S759-&date=2016&auinit1=K&auinitm=J
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 270
TITLE
  Percutaneous tracheostomy in post-cervical spine fixation patients: 
Challenging the dogma
AUTHOR NAMES
  Gupta S.; Singh P.; Soni K.D.; Aggarwal R.; Yadav D.
AUTHOR ADDRESSES
  (Gupta S., mail2guptasumit88@gmail.com; Singh P.; Yadav D.) Department of 
Anesthesia, Intensive Care and Pain Medicine, AIIMS, New Delhi, Delhi, 
India.
(Soni K.D., kdsoni111@gmail.com; Aggarwal R.) Department of Intensive Care, 
JPNATC, AIIMS, New Delhi, Delhi, India.
CORRESPONDENCE ADDRESS
  S. Gupta, Department of Anesthesia, Intensive Care and Pain Medicine, AIIMS, 
New Delhi, Delhi, India. Email: mail2guptasumit88@gmail.com
AiP/IP ENTRY DATE
  2016-03-28
FULL RECORD ENTRY DATE
  2016-06-16
SOURCE
  American Journal of Emergency Medicine (2016) 34:5 (910-911). Date of 
Publication: 1 May 2016
VOLUME
  34
ISSUE
  5
FIRST PAGE
  910
LAST PAGE
  911
DATE OF PUBLICATION
  1 May 2016
ISSN
  1532-8171 (electronic)
  0735-6757
BOOK PUBLISHER
  W.B. Saunders
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fixation; percutaneous dilatational tracheostomy; postoperative period; spine stabilization; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; bronchoscopy; bronchospasm; endotracheal tube; female; heart arrest; human; letter; perioperative period; priority journal; quadriplegia; surgical patient; traffic accident; ultrasound; X ray; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160228644
MEDLINE PMID
  26944106 (http://www.ncbi.nlm.nih.gov/pubmed/26944106)
PUI
  L609128370
DOI
  10.1016/j.ajem.2016.02.019
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ajem.2016.02.019
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15328171&id=doi:10.1016%2Fj.ajem.2016.02.019&atitle=Percutaneous+tracheostomy+in+post-cervical+spine+fixation+patients%3A+Challenging+the+dogma&stitle=Am.+J.+Emerg.+Med.&title=American+Journal+of+Emergency+Medicine&volume=34&issue=5&spage=910&epage=911&aulast=Gupta&aufirst=Sumit&auinit=S.&aufull=Gupta+S.&coden=AJEME&isbn=&pages=910-911&date=2016&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 271
TITLE
  En Bloc Resection of Primary Malignant Bone Tumor in the Cervical Spine 
Based on 3-Dimensional Printing Technology
AUTHOR NAMES
  Xiao J.-R.; Huang W.-D.; Yang X.-H.; Yan W.-J.; Song D.-W.; Wei H.-F.; Liu T.-L.; Wu Z.-P.; Yang C.
AUTHOR ADDRESSES
  (Xiao J.-R., jianruxiao83@163.com; Yang X.-H.; Yan W.-J.; Song D.-W.; Wei 
H.-F.; Liu T.-L.; Wu Z.-P.; Yang C.) Department of Orthopaedic Oncology, 
Spine Tumor Center, Changzheng Hospital, Second Military Medical University, 
Shanghai, China.
(Huang W.-D.) Department of Orthopaedics, 411th Hospital of the People's 
Liberation Army, Shanghai, China.
CORRESPONDENCE ADDRESS
  J.-R. Xiao, Department of Orthopaedic Oncology, Spine Tumor Center, 
Changzheng Hospital, Second Military Medical University, Shanghai, China. 
Email: jianruxiao83@163.com
AiP/IP ENTRY DATE
  2016-07-15
FULL RECORD ENTRY DATE
  2016-07-25
SOURCE
  Orthopaedic Surgery (2016) 8:2 (171-178). Date of Publication: 1 May 2016
VOLUME
  8
ISSUE
  2
FIRST PAGE
  171
LAST PAGE
  178
DATE OF PUBLICATION
  1 May 2016
ISSN
  1757-7853
BOOK PUBLISHER
  Sociedade Brasileira de Matematica Aplicada e Computacional, rmac@Incc.br
ABSTRACT
  Objective: To investigate the feasibility and safety of en bloc resection of 
cervical primary malignant bone tumors by a combined anterior and posterior 
approach based on a three-dimensional (3-D) printing model. Methods: Five 
patients with primary malignant bone tumors of the cervical spine underwent 
en bloc resection via a one-stage combined anteroposterior approach in our 
hospital from March 2013 to June 2014. They comprised three men and two 
women of mean age 47.2 years (range, 26–67 years). Three of the tumors were 
chondrosarcomas and two chordomas. Preoperative 3-D printing models were 
created by 3-D printing technology. Sagittal en bloc resections were planned 
based on these models and successfully performed. A 360° reconstruction was 
performed by spinal instrumentation in all cases. Surgical margins, 
perioperative complications, local control rate and survival rate were 
assessed. Results: All patients underwent en bloc excision via a combined 
posterior and anterior approach in one stage. Mean operative time and 
estimated blood loss were 465 minutes and 1290 mL, respectively. Mean 
follow-up was 21 months. Wide surgical margins were achieved in two patients 
and marginal resection in three; these three patients underwent 
postoperative adjuvant radiation therapy. One vertebral artery was ligated 
and sacrificed in each of three patients. Nerve root involved by tumor was 
sacrificed in three patients with preoperative upper extremity weakness. One 
patient (Case 3) had significant transient radiculopathy with paresis 
postoperatively. Another (Case 4) with C (4) and C (5) chordoma had 
respiratory difficulties and pneumonia after surgery postoperatively. He 
recovered completely after 2 weeks’ management with a tracheotomy tube and 
antibiotics in the intensive care unit. No cerebrovascular complications and 
wound infection were observed. No local recurrence or instrumentation 
failure were detected during follow-up. Conclusion: Though technically 
challenging, it is feasible and safe to perform en bloc resection of 
cervical primary bone tumors. This is the most effective means of managing 
cervical spine tumors. Preoperative 3-D printing modelling enables better 
anatomical understanding of the relationship between the tumor and cervical 
spine and can assist in planning the surgical procedure.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer surgery; en bloc resection; spine surgery; spine tumor (diagnosis, radiotherapy, surgery); three dimensional printing; 
EMTREE MEDICAL INDEX TERMS
  adjuvant radiotherapy; adult; aged; article; cancer radiotherapy; cancer recurrence; cancer staging; cancer survival; chondrosarcoma; chordoma; clinical article; computed tomographic angiography; computed tomography scanner; diaphragm paralysis (complication); dysphagia (complication); feasibility study; female; follow up; Horner syndrome (complication); human; image reconstruction; intensive care unit; male; middle aged; nuclear magnetic resonance imaging; operation duration; outcome assessment; paresis; pneumonia (complication); postoperative hemorrhage (complication); preoperative period; radicular pain (complication); radiculopathy; recurrent laryngeal nerve palsy (complication); retrospective study; survival rate; tracheotomy; tumor diagnosis; wound infection (complication); 
DEVICE TRADE NAMES
  CT scanner;  , United StatesSiemens

DEVICE MANUFACTURERS
   (United States)Siemens
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Gerontology and Geriatrics (20)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160509213
MEDLINE PMID
  27384725 (http://www.ncbi.nlm.nih.gov/pubmed/27384725)
PUI
  L611169266
DOI
  10.1111/os.12234
FULL TEXT LINK
  http://dx.doi.org/10.1111/os.12234
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17577853&id=doi:10.1111%2Fos.12234&atitle=En+Bloc+Resection+of+Primary+Malignant+Bone+Tumor+in+the+Cervical+Spine+Based+on+3-Dimensional+Printing+Technology&stitle=Orthop.+Surg.&title=Orthopaedic+Surgery&volume=8&issue=2&spage=171&epage=178&aulast=Xiao&aufirst=Jian-Ru&auinit=J.-R.&aufull=Xiao+J.-R.&coden=&isbn=&pages=171-178&date=2016&auinit1=J&auinitm=-R
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 272
TITLE
  ALS patients with ability to communicate after long-term mechanical 
ventilation have confined degeneration to the motor neuron system
AUTHOR NAMES
  Mochizuki Y.; Hayashi K.; Nakayama Y.; Shimizu T.; Kamide M.; Ogino M.; Komori T.; Hasegawa M.; Isozaki E.; Nakano I.
AUTHOR ADDRESSES
  (Mochizuki Y., mochi@nihon-u.ne.jp; Komori T.) Department of Pathology, 
Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
(Hayashi K.; Shimizu T.; Isozaki E.; Nakano I.) Department of Neurology, 
Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
(Nakayama Y.) Laboratory of Nursing Research for Intractable Disease, Tokyo 
Metropolitan Institute of Medical Science, Tokyo, Japan.
(Kamide M.) Emergency Department of Atsugi City Hospital, Kanagawa, Japan.
(Ogino M.) Division of Integrated Care and Whole Person Care, Department of 
Comprehensive Medicine, Research and Development Center for New Medical 
Frontiers, Kitasato University School of Medicine, Kanagawa, Japan.
(Hasegawa M.) Department of Dementia and Higher Brain Function, Tokyo 
Metropolitan Institute of Medical Science, Tokyo, Japan.
(Mochizuki Y., mochi@nihon-u.ne.jp) Department of Neurology, Tokyo 
Metropolitan Kita Medical and Rehabilitation Center for the Disabled, 1-2-3 
Jujodai, Kita-ku, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  Y. Mochizuki, Department of Pathology, Tokyo Metropolitan Neurological 
Hospital, Tokyo, Japan. Email: mochi@nihon-u.ne.jp
AiP/IP ENTRY DATE
  2016-03-14
FULL RECORD ENTRY DATE
  2019-05-14
SOURCE
  Journal of the Neurological Sciences (2016) 363 (245-248). Date of 
Publication: 15 Apr 2016
VOLUME
  363
FIRST PAGE
  245
LAST PAGE
  248
DATE OF PUBLICATION
  15 Apr 2016
ISSN
  1878-5883 (electronic)
  0022-510X
BOOK PUBLISHER
  Elsevier B.V.
ABSTRACT
  Objective To clarify the position in the amyotrophic lateral sclerosis (ALS) 
spectrum, of a subgroup of patients who maintained the ability to 
communicate after long-term mechanical ventilation (LTMV) by tracheostomy. 
Methods We undertook a clinicopathological investigation of sporadic ALS in 
three patients who maintained the ability to communicate after approximately 
30-year survival on LTMV by tracheostomy. Results The age of onset and 
duration of disease was 48 years and 31 years in patient 1, 55 years and 29 
years in patient 2, and 31 years and 33 years in patient 3, respectively. 
Each patient displayed slow disease progression. In all patients, both upper 
and lower motor neurons were markedly degenerated, while other neuronal 
systems and the brainstem tegmentum were spared. A few normal-looking motor 
neurons remained in the anterior horn of the spinal cord. There were no TAR 
DNA-binding protein 43-immunoreactive inclusions in the lower motor neurons 
in any patient and only occasional inclusions in the cerebral cortex of one 
patient. Conclusion The clinicopathological findings of these three patients 
suggest that there is a distinct subgroup of ALS patients characterized by 
the above-mentioned features.
EMTREE DRUG INDEX TERMS
  TAR DNA binding protein (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (etiology, surgery, therapy); artificial ventilation; interpersonal communication; motoneuron; 
EMTREE MEDICAL INDEX TERMS
  adult; arm weakness; article; brain cortex; brain stem; brain tissue; case report; cell inclusion; clinical feature; disease course; disease duration; human; human tissue; inferior olivary nucleus; male; medulla oblongata; middle aged; muscle atrophy; neuropathology; onset age; priority journal; reticular formation; spasticity; spinal cord; spinal cord atrophy; spinal cord ventral horn; survival; tegmentum; tracheostomy; tumor spheroid; Western blotting; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  27000258 (http://www.ncbi.nlm.nih.gov/pubmed/27000258)
PUI
  L608753346
DOI
  10.1016/j.jns.2016.02.068
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jns.2016.02.068
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18785883&id=doi:10.1016%2Fj.jns.2016.02.068&atitle=ALS+patients+with+ability+to+communicate+after+long-term+mechanical+ventilation+have+confined+degeneration+to+the+motor+neuron+system&stitle=J.+Neurol.+Sci.&title=Journal+of+the+Neurological+Sciences&volume=363&issue=&spage=245&epage=248&aulast=Mochizuki&aufirst=Yoko&auinit=Y.&aufull=Mochizuki+Y.&coden=JNSCA&isbn=&pages=245-248&date=2016&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2019 Elsevier B.V., All rights reserved.

RECORD 273
TITLE
  A case series expanding the phenotypic variations in spinal muscular atrophy 
type I
AUTHOR NAMES
  Lopez M.; Wagle M.; Abid F.
AUTHOR ADDRESSES
  (Lopez M.; Wagle M.; Abid F.)
CORRESPONDENCE ADDRESS
  M. Lopez,
FULL RECORD ENTRY DATE
  2016-04-27
SOURCE
  Neurology (2016) 86:16 SUPPL. 1. Date of Publication: 5 Apr 2016
VOLUME
  86
ISSUE
  16
DATE OF PUBLICATION
  5 Apr 2016
CONFERENCE NAME
  68th American Academy of Neurology Annual Meeting, AAN 2016
CONFERENCE LOCATION
  Vancouver, BC, Canada
CONFERENCE DATE
  2016-04-15 to 2016-04-21
ISSN
  0028-3878
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Objective: To expand the spectrum of phenotypes in patients with Spinal 
Muscular Atrophy Type I Background: Spinal Muscular Atrophy (SMA) is the 
most common infant motor neuron disease and a leading cause of infant death. 
Those with Type I SMA present with symptoms within the first 6 months and 
never roll, sit, walk, and run. Death is expected before the age of 2 years, 
with one paper demonstrating some survival past 4 years with respiratory 
intervention. Methods: The medical records of our patients were reviewed for 
pertinent findings associated with SMA. Results: We have identified a series 
of eight patients between the ages of 17 months and 14 years who clinically 
fit the phenotype of SMA Type I. Each patient presented with symptoms of 
hypotonia, delayed motor skills, weakness, areflexia, and fasciculations 
within the first six months of age. Genetic testing for all patients 
revealed homozygous deletions of exons seven and eight of SMN1. Patients of 
17 months, 2 years, 5 years, and 14 years of age were not dependent on 
tracheostomy and mechanical ventilation. See Table 1 for pulmonary status by 
age. One patient was tested and found to have only three copies of SMN2. 
Table 1. Age Pulmonary 17 mo Cough assist 2 yrs BiPAP 3 yrs Trach/Mechanical 
ventilation 5 yrs Cough assist, BiPAP at night, IPV 6 yrs Trach/mechanical 
ventilation 7 yrs Trach/mechanical ventilation 12 yrs Trach/mechanical 
ventilation 14 yrs Noninvasive ventilation (PPIV) Conclusions: We report a 
series of eight patients with clinical presentation and genetic testing 
consistent with SMA Type I. Presently, six out of eight patients in the 
series have survived more than two years. This series expands the phenotype 
of SMA Type I, which has important implications for prognosis. It suggests 
that future investigations into gene modifying factors, such as SMN2 copy 
number, may be beneficial.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; case study; neurology; phenotypic variation; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; areflexia; artificial ventilation; child death; death; exon; genetic screening; human; infant; medical record; modifier gene; motor neuron disease; motor performance; muscle hypotonia; night; non continuous ventilator; noninvasive ventilation; patient; phenotype; prognosis; survival; tracheostomy; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72252969
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00283878&id=doi:&atitle=A+case+series+expanding+the+phenotypic+variations+in+spinal+muscular+atrophy+type+I&stitle=Neurology&title=Neurology&volume=86&issue=16&spage=&epage=&aulast=Lopez&aufirst=Michael&auinit=M.&aufull=Lopez+M.&coden=&isbn=&pages=-&date=2016&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 274
TITLE
  A case series expanding the phenotypic variations in spinal muscular atrophy 
type I
AUTHOR NAMES
  Lopez M.; Wagle M.; Abid F.
AUTHOR ADDRESSES
  (Lopez M.; Wagle M.; Abid F.) Section of Pediatric Neurology and 
Developmental Neuroscience, Baylor College of Medicine, Texas Children's 
Hospital, Houston, United States.
CORRESPONDENCE ADDRESS
  M. Lopez, Section of Pediatric Neurology and Developmental Neuroscience, 
Baylor College of Medicine, Texas Children's Hospital, Houston, United 
States.
FULL RECORD ENTRY DATE
  2016-04-27
SOURCE
  Neurology (2016) 86:16 SUPPL. 1. Date of Publication: 5 Apr 2016
VOLUME
  86
ISSUE
  16
DATE OF PUBLICATION
  5 Apr 2016
CONFERENCE NAME
  68th American Academy of Neurology Annual Meeting, AAN 2016
CONFERENCE LOCATION
  Vancouver, BC, Canada
CONFERENCE DATE
  2016-04-15 to 2016-04-21
ISSN
  0028-3878
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Objective: To expand the spectrum of phenotypes in patients with Spinal 
Muscular Atrophy Type I Background: Spinal Muscular Atrophy (SMA) is the 
most common infant motor neuron disease and a leading cause of infant death. 
Those with Type I SMA present with symptoms within the first 6 months and 
never roll, sit, walk, and run. Death is expected before the age of 2 years, 
with one paper demonstrating some survival past 4 years with respiratory 
intervention. Methods: The medical records of our patients were reviewed for 
pertinent findings associated with SMA. Results: We have identified a series 
of eight patients between the ages of 17 months and 14 years who clinically 
fit the phenotype of SMA Type I. Each patient presented with symptoms of 
hypotonia, delayed motor skills, weakness, areflexia, and fasciculations 
within the first six months of age. Genetic testing for all patients 
revealed homozygous deletions of exons seven and eight of SMN1. Patients of 
17 months, 2 years, 5 years, and 14 years of age were not dependent on 
tracheostomy and mechanical ventilation. See Table 1 for pulmonary status by 
age. One patient was tested and found to have only three copies of SMN2. 
Table 1. Age Pulmonary 17 mo Cough assist 2 yrs BiPAP 3 yrs Trach/Mechanical 
ventilation 5 yrs Cough assist, BiPAP at night, IPV 6 yrs Trach/mechanical 
ventilation 7 yrs Trach/mechanical ventilation 12 yrs Trach/mechanical 
ventilation 14 yrs Noninvasive ventilation (PPIV) Conclusions: We report a 
series of eight patients with clinical presentation and genetic testing 
consistent with SMA Type I. Presently, six out of eight patients in the 
series have survived more than two years. This series expands the phenotype 
of SMA Type I, which has important implications for prognosis. It suggests 
that future investigations into gene modifying factors, such as SMN2 copy 
number, may be beneficial.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; case study; neurology; phenotypic variation; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; areflexia; artificial ventilation; child death; death; exon; genetic screening; human; infant; medical record; modifier gene; motor neuron disease; motor performance; muscle hypotonia; night; non continuous ventilator; noninvasive ventilation; patient; phenotype; prognosis; survival; tracheostomy; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72251210
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00283878&id=doi:&atitle=A+case+series+expanding+the+phenotypic+variations+in+spinal+muscular+atrophy+type+I&stitle=Neurology&title=Neurology&volume=86&issue=16&spage=&epage=&aulast=Lopez&aufirst=Michael&auinit=M.&aufull=Lopez+M.&coden=&isbn=&pages=-&date=2016&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 275
TITLE
  Physiotherapy and noninvasive respiratory management as adjuvant to prevent 
early tracheostomy in spinal muscular atrophy type i
AUTHOR NAMES
  Magalhães P.A.F.; D'Amorim A.C.G.; Mendes A.P.A.; Ramos M.E.A.; De Almeida L.B.S.; Do Carmo Menezes Bezerra Duarte M.
AUTHOR ADDRESSES
  (Magalhães P.A.F.; D'Amorim A.C.G.; Do Carmo Menezes Bezerra Duarte M.) 
Programa De Pós-graduação em Saúde Materno Infantil, Instituto De Medicina 
Integra, Brazil.
(D'Amorim A.C.G.; Mendes A.P.A.; Ramos M.E.A.) Real Hospital Português De 
Beneficência em Pernambuco, Brazil.
(De Almeida L.B.S.) Associação De Assistência à Criança Deficiente (AACD, 
Brazil.
CORRESPONDENCE ADDRESS
  A.C.G. D'Amorim, Programa De Pós-graduação em Saúde Materno Infantil, 
Instituto De Medicina Integra, Brazil.
FULL RECORD ENTRY DATE
  2016-08-15
SOURCE
  Pediatric Pulmonology (2016) 51 Supplement 42 (S43). Date of Publication: 1 
Apr 2016
VOLUME
  51
FIRST PAGE
  S43
DATE OF PUBLICATION
  1 Apr 2016
CONFERENCE NAME
  11th SOLANEP International Congress, 15th Cystic Fibrosis Latinamerican 
Congress and 15th Brazilian Congress of Pediatric Pulmonology
CONFERENCE LOCATION
  Florianopolis, Brazil
CONFERENCE DATE
  2016-04-13 to 2016-04-16
ISSN
  1099-0496
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Objective: Spinal atrophy type 1 (SMA1) is an autosomal recessive genetic 
disease which promotes cell death ofmotor neurons located in the ventral 
horn of the spinal cord and brainstemnuclei engines. Earlymorbidity 
andmortality in this group is associated with bulbar dysfunction and 
respiratory failure requiring hospitalization and artificial ventilation. A 
large proportion of this population is considered difficult to wean from 
mechanical ventilation. Tracheostomy is considered treatment of choice for 
children with SMA 1. However, recent studies have been suggested noninvasive 
respiratory management as adjuvant to prevent early tracheostomy. The aim of 
the present study was to promulgate awareness of maintaining a patient with 
SMA 1 without the use of invasive ventilation and with a personalized 
physiotherapy protocol, thereby providing better quality of life and 
integration with family members. Case description: a case study of a minor 
diagnosed withSMA1, who, at the age of elevenmonths, underwent invasive 
mechanical ventilation (IMV) for 76 days, with successful weaning after 
application of a respiratory physiotherapy protocol, including use of 
mechanically assisted coughing and non-invasive ventilation (NIV). 
Discussion: despite the difficulties and complications observed, the 
assistance proposed achieved the objective of removal of IMV and transfer to 
home care using non-invasive ventilation. IMV via tracheostomy is the 
treatment of choice in Brazil but families need to be informed of the 
irreversibility of the disease and the strategic possibilities of current 
therapies (IMV, NIV and palliative care) for management of a child with 
severe SMA 1.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  adjuvant; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing exercise; prevention; tracheostomy; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  awareness; Brazil; case report; child; coughing; diagnosis; family study; home care; human; noninvasive ventilation; palliative therapy; quality of life; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L611614499
DOI
  10.1002/ppul.23409
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.23409
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10990496&id=doi:10.1002%2Fppul.23409&atitle=Physiotherapy+and+noninvasive+respiratory+management+as+adjuvant+to+prevent+early+tracheostomy+in+spinal+muscular+atrophy+type+i&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=51&issue=&spage=S43&epage=&aulast=Magalh%C3%A3es&aufirst=Paulo+Andr%C3%A9+Freire&auinit=P.A.F.&aufull=Magalh%C3%A3es+P.A.F.&coden=&isbn=&pages=S43-&date=2016&auinit1=P&auinitm=A.F.
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 276
TITLE
  Cerebral and spinal anomalies in one monochorionic twin with 
schimmelpenning-feuerstein-mims syndrome
AUTHOR NAMES
  Gruber-Sedlmayr U.; Hubmann H.; Haidl H.; Brunner-Krainz M.; Schwerin-Nagel A.; Schwerin-Nagel A.; Kortschak A.; Haber E.; Sorantin E.
AUTHOR ADDRESSES
  (Gruber-Sedlmayr U.; Hubmann H.; Haidl H.; Brunner-Krainz M.; Schwerin-Nagel 
A.; Schwerin-Nagel A.; Kortschak A.; Haber E.) Medical University of Graz, 
Department of Pediatrics, Austria.
(Sorantin E.) Medical University of Graz, Department of Radiology, Division 
of Pediatric Radiology, Austria.
CORRESPONDENCE ADDRESS
  U. Gruber-Sedlmayr, Medical University of Graz, Department of Pediatrics, 
Austria.
FULL RECORD ENTRY DATE
  2017-04-17
SOURCE
  Neuropediatrics (2016) 47 Supplement 1. Date of Publication: 1 Apr 2016
VOLUME
  47
DATE OF PUBLICATION
  1 Apr 2016
CONFERENCE NAME
  42nd Annual Meeting of the Society for Neuropediatrics
CONFERENCE LOCATION
  Bochum, Germany
CONFERENCE DATE
  2016-04-21 to 2016-04-24
ISSN
  1439-1899
BOOK PUBLISHER
  Hippokrates Verlag GmbH
ABSTRACT
  Background: Schimmelpenning-Feuerstein-Mims syndrome (SFM) is a 
neurocutaneous disorder with nevus sebaceous in association with cerebral, 
ocular or skeletal defects. Postzygotic HRAS (chromosome 11p15.5) and KRAS 
(chromosome 12p12.1) mutations can be found in the lesions. Case Report: We 
report a 2-year-old boy, born preterm by cesarian section after complicated 
twin pregnancy because of fetofetal transfusion syndrome. He presented with 
multiple nevus sebaceous predominantly on the right side of the head and 
thorax and with a malformation of the right bulbus oculi and eyelid. HRAS 
mutation was found in the naevi. Because of cyanotic attacks, a tracheostoma 
and a percutaneous endoscopic gastrostoma were necessary at the age of 6 
months. When he was 11 months old, he developed focal seizures partly with 
generalization. The cerebral MRT showed malformation with polygyria, nearly 
absent myelinization, signs of atrophy, a cystic defect of the right 
occipital lobe, and enlarged cervical nerve roots. A MRT of the whole spine 
was performed. It showed increased thickness of the nerve roots cervical, 
thoracal and lumbar and three lipomas extramedullary. The boy is 
developmentally retarded, but is able to grasp with both hands and he can 
move both legs without signs of spinal cord compression. The epilepsy is 
controlled by ketogenic diet in combination with topiramate and 
levetiracetam. Result: We describe the first patient with SFM syndrome 
confirmed by genetic analysis with enlargement of all nerve roots. The 
prognosis with regard to spinal compression of this patient is unclear.
EMTREE DRUG INDEX TERMS
  endogenous compound; levetiracetam; topiramate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  focal epilepsy; occipital lobe; spinal cord malformation; 
EMTREE MEDICAL INDEX TERMS
  atrophy; case report; cesarean section; child; eyeball; eyelid; female; gastrostomy; gene mutation; genetic analysis; human; ketogenic diet; leg; lipoma; lumbar region; male; myelination; nerve root; nevus; oncogene c H ras; preschool child; prognosis; spinal cord compression; spine; thickness; thorax; trachea stoma; twin pregnancy; twin twin transfusion syndrome; 
CAS REGISTRY NUMBERS
  levetiracetam (102767-28-2)
  topiramate (97240-79-4)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L615322680
DOI
  10.1055/s-0036-1583686
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0036-1583686
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14391899&id=doi:10.1055%2Fs-0036-1583686&atitle=Cerebral+and+spinal+anomalies+in+one+monochorionic+twin+with+schimmelpenning-feuerstein-mims+syndrome&stitle=Neuropediatrics&title=Neuropediatrics&volume=47&issue=&spage=&epage=&aulast=Gruber-Sedlmayr&aufirst=U.&auinit=U.&aufull=Gruber-Sedlmayr+U.&coden=&isbn=&pages=-&date=2016&auinit1=U&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 277
TITLE
  Diaphragmatic pacing stimulation: Anesthetic management at institut guttmann
AUTHOR NAMES
  Alegret Monroig N.; Serra P.; Pere Pessas J.
AUTHOR ADDRESSES
  (Alegret Monroig N.; Serra P.; Pere Pessas J.) Institut Guttmann, Barcelona, 
Spain.
CORRESPONDENCE ADDRESS
  N. Alegret Monroig, Institut Guttmann, Barcelona, Spain.
FULL RECORD ENTRY DATE
  2017-01-16
SOURCE
  Journal of Neurosurgical Anesthesiology (2016) 28:2 (S6-S7). Date of 
Publication: 1 Apr 2016
VOLUME
  28
ISSUE
  2
FIRST PAGE
  S6
LAST PAGE
  S7
DATE OF PUBLICATION
  1 Apr 2016
CONFERENCE NAME
  9th International Update on Neuroanesthesia and Neurointensive Care, 
EURONEURO 2016
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2016-04-14 to 2016-04-16
ISSN
  1537-1921
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: Diaphragm pacing (DP) has been shown to successfully replace 
mechanical ventilators for patients affected by spinal cord injuries, 
amyotrophic lateral sclerosis, and other neurological injuries with chronic 
respiratory insufficiency, improving quality of life and decreasing 
morbidity, mortality, and health costs. From an anesthetic perspective, both 
the surgery and the patient population present several unique challenges. 
The aim of this study is the analysis of the anesthetic management and 
intraoperative complications of patients undergoing insertion of a DP in our 
institution. Methods: With IRB approval, retrospective review was conducted 
from December 2007 to July 2015. Data register of patient previous state, 
anesthetic technique, and intraoperative complications due both to 
anesthetic technique or surgery were collected. Results: We included 16 
patients (5 pediatric) with DP indication due to spinal cord injuries, 63%; 
amyotrophic lateral sclerosis, 25%; or other neurological diseases, 12%. 
General anesthesia was required for the abdominal laparoscopy; we used 
intravenous 87% versus inhalatory induction 13% and total intravenous 
anesthesia (TIVA) 50% versus balanced 50% for maintenance anesthesia. 
Succinylcholine was administered to 31% of the patients for orotracheal 
intubation. Anesthetic deepening was needed during the surgery for 
pneumoperitoneum tolerance in 50% of the cases in the balanced anesthesia 
group and in 25% of the cases in the TIVA group. Registered complications 
were: 31% mechanical ventilation difficulty during laparoscopy, pneumotorax 
12.5%, and autonomic dysreflexia 6%. Discussion: Although few studies about 
perioperative management for DP surgery and none in pediatric patients are 
available, all agree in the need of diaphragmatic contraction visualization 
during the procedure, so neuromuscular blocking agents should be avoided 
during surgery. Our report is the first using depolarizing neuromuscular 
blocker at the anesthetic induction with no consequences on the 
diaphragmatic mapping. We are describing for first time inhalatory induction 
through tracheostomy and TIVA for maintenance anesthesia in DP surgery with 
satisfactory results. Our incidence of complications is comparable to other 
studies. Conclusions: The implantation of DP is a safe technique with the 
potential to improve the quality of life of patients dependent on mechanical 
ventilation. Appropriate intraoperative care is fundamental to achieving 
better results. Nevertheless larger, randomized, prospective studies are 
required.
EMTREE DRUG INDEX TERMS
  neuromuscular blocking agent; suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm; 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; artificial ventilation; autonomic dysreflexia; balanced anesthesia; child; clinical article; clinical trial; controlled clinical trial; controlled study; endotracheal intubation; general anesthesia; human; implantation; intravenous anesthesia; laparoscopy; muscle contractility; peroperative care; peroperative complication; pneumoperitoneum; prospective study; quality of life; randomized controlled trial; retrospective study; spinal cord injury; surgery; tracheostomy; 
CAS REGISTRY NUMBERS
  suxamethonium (306-40-1, 71-27-2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L614034056
DOI
  10.1097/ANA.0000000000000287
FULL TEXT LINK
  http://dx.doi.org/10.1097/ANA.0000000000000287
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15371921&id=doi:10.1097%2FANA.0000000000000287&atitle=Diaphragmatic+pacing+stimulation%3A+Anesthetic+management+at+institut+guttmann&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=28&issue=2&spage=S6&epage=S7&aulast=Alegret+Monroig&aufirst=N.&auinit=N.&aufull=Alegret+Monroig+N.&coden=&isbn=&pages=S6-S7&date=2016&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 278
TITLE
  Pneumocephalus leading to the diagnosis of cerebrospinal fluid leak and 
esophageal perforation after cervical spine surgery
AUTHOR NAMES
  Goodwin C.R.; Boone C.E.; Pendleton J.; Elder B.D.; Wei Z.; Hsu W.; Sciubba D.M.; Witham T.F.
AUTHOR ADDRESSES
  (Goodwin C.R.; Boone C.E.; Pendleton J.; Elder B.D.; Wei Z.; Sciubba D.M.; 
Witham T.F., twitham2@jhmi.edu) Department of Neurosurgery, Johns Hopkins 
Medical Institutions, Meyer Building, 5-181 600 N. Wolfe Steet, Baltimore, 
United States.
(Hsu W.) Department of Neurosurgery, Wake Forest Baptist Medical Center, 
Winston-Salem, United States.
CORRESPONDENCE ADDRESS
  T.F. Witham, Department of Neurosurgery, Johns Hopkins Medical Institutions, 
Meyer Building, 5-181 600 N. Wolfe Steet, Baltimore, United States. Email: 
twitham2@jhmi.edu
AiP/IP ENTRY DATE
  2015-11-27
FULL RECORD ENTRY DATE
  2016-06-28
SOURCE
  Journal of Clinical Neuroscience (2016) 26 (141-142). Date of Publication: 1 
Apr 2016
VOLUME
  26
FIRST PAGE
  141
LAST PAGE
  142
DATE OF PUBLICATION
  1 Apr 2016
ISSN
  1532-2653 (electronic)
  0967-5868
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  Pneumocephalus is a collection of air within in the intracranial cavity, 
most commonly seen following traumatic injury or cranial surgeries. 
Esophageal injury and cerebrospinal fluid (CSF) leak are rare complications 
that may occur following anterior cervical discectomy and fusion (ACDF). We 
present a novel case of pneumocephalus arising from unrestricted leakage of 
CSF via coincident esophageal injury and durotomy in a patient who underwent 
an ACDF after trauma. A 21-year-old man presented to an outside hospital 
with C5/C6 subluxation, complete spinal cord injury, and quadriplegia from a 
motor vehicle accident. He underwent an ACDF, during which a CSF leak was 
observed. He was then transferred to our institution for rehabilitation and 
tracheostomy placement 1 week after the ACDF surgery. Following the 
tracheostomy, the patient developed intractable fevers and nonspecific 
symptoms. A CT scan demonstrated frontal pneumocephalus without mass effect. 
Air was found in the retropharyngeal space. There were no accumulations of 
CSF in the neck. Extravasation of contrast around instrumentation at C5/C6 
on a cine esophagogram demonstrated an esophageal perforation at that level. 
Pneumocephalus may form when large volumes of CSF escape from the 
intracranial space and air is drawn into the space by the negative pressure. 
In this unusual case, the esophageal perforation promoted the formation of 
the pneumocephalus. Treatment included closure of both defects, disrupting 
the suspected communication between the intracranial space and the 
esophagus.
EMTREE DRUG INDEX TERMS
  antibiotic agent; macrogol; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus perforation (complication, diagnosis); liquorrhea (complication, diagnosis); pneumocephalus (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  abscess (complication, surgery); adult; anterior cervical discectomy and fusion; article; case report; cerebrospinal fluid culture; cervical abscess (complication, surgery); computer assisted tomography; debridement; esophagography; esophagoscopy; extravasation; fever; Gram negative bacterium; Gram positive bacterium; hematoma (complication, surgery); hospital discharge; human; intraoperative period; laryngoscopy; male; postoperative period; priority journal; quadriplegia; rehabilitation care; spinal cord injury (surgery); spine surgery; surgical drainage; symptom; tracheostomy; traffic accident; vertebra dislocation (surgery); young adult; 
CAS REGISTRY NUMBERS
  macrogol (25322-68-3)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Gastroenterology (48)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015533156
MEDLINE PMID
  26778810 (http://www.ncbi.nlm.nih.gov/pubmed/26778810)
PUI
  L607019309
DOI
  10.1016/j.jocn.2015.10.016
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jocn.2015.10.016
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15322653&id=doi:10.1016%2Fj.jocn.2015.10.016&atitle=Pneumocephalus+leading+to+the+diagnosis+of+cerebrospinal+fluid+leak+and+esophageal+perforation+after+cervical+spine+surgery&stitle=J.+Clin.+Neurosci.&title=Journal+of+Clinical+Neuroscience&volume=26&issue=&spage=141&epage=142&aulast=Goodwin&aufirst=C.+Rory&auinit=C.R.&aufull=Goodwin+C.R.&coden=JCNUE&isbn=&pages=141-142&date=2016&auinit1=C&auinitm=R
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 279
TITLE
  Planned ventral hernia following damage control laparotomy in trauma: an 
added year of recovery but equal long-term outcome
AUTHOR NAMES
  Zosa B.M.; Como J.J.; Kelly K.B.; He J.C.; Claridge J.A.
AUTHOR ADDRESSES
  (Zosa B.M.; Como J.J., jcomo@metrohealth.org; Kelly K.B.; He J.C.; Claridge 
J.A.) MetroHealth Medical Center, Case Western Reserve University School of 
Medicine, 2500 MetroHealth Dr., Cleveland, United States.
CORRESPONDENCE ADDRESS
  J.J. Como, MetroHealth Medical Center, Case Western Reserve University 
School of Medicine, 2500 MetroHealth Dr., Cleveland, United States. Email: 
jcomo@metrohealth.org
AiP/IP ENTRY DATE
  2015-04-24
FULL RECORD ENTRY DATE
  2016-04-06
SOURCE
  Hernia (2016) 20:2 (231-238). Date of Publication: 1 Apr 2016
VOLUME
  20
ISSUE
  2
FIRST PAGE
  231
LAST PAGE
  238
DATE OF PUBLICATION
  1 Apr 2016
ISSN
  1248-9204 (electronic)
  1265-4906
BOOK PUBLISHER
  Springer-Verlag France, 22, Rue de Palestro, Paris, France. 
york@springer-paris.fr
ABSTRACT
  Purpose: Significantly injured trauma patients commonly require damage 
control laparotomy (DCL). These patients undergo either primary fascial 
closure during the index hospitalization or are discharged with a planned 
ventral hernia. Hospital and long-term outcomes of these patients have not 
been extensively studied. Methods: Patients who underwent DCL for trauma 
from 2003 to 2012 at a regional Level I trauma center were identified and a 
comparison was made between those who had primary fascial closure and 
planned ventral hernia. Results: DCL was performed in 154 patients, 47 % of 
whom sustained penetrating injuries. The mean age and injury severity score 
(ISS) were 40 and 25, respectively. Hospital mortality was 19 %. Primary 
fascial closure was performed in 115 (75 %) of those undergoing DCL during 
the index hospitalization. Of these, 11 (9 %) had reopening of the fascia. 
Of the surviving patients, 22 (19 %) never had primary fascial closure and 
were discharged with a planned ventral hernia. Patients with primary fascial 
closure and those with planned ventral hernia were similar in age, gender, 
ISS, and mechanism. Those with planned ventral hernias underwent more 
subsequent laparotomies (3.0 vs 1.3, p < 0.001), and had more enteric 
fistulas (18.2 vs 4.3 %, p = 0.041) and intra-abdominal infections (46 vs 
15 %, p = 0.007), and had a greater number of hospital days (38 vs 25, 
p = 0.007) during the index hospitalization. Sixteen (73 %) patients with a 
planned ventral hernia had definitive reconstruction (mean days = 266). Once 
definitive abdominal wall closure was achieved, the two groups achieved 
similar rates of return to work and usual activity (71 vs 70 %, p = NS). 
Conclusions: Following DCL for trauma, patients with a planned ventral 
hernia have definitive reconstruction nearly 9 months after the initial 
injury. Once definitive abdominal wall closure has been achieved; patients 
with primary fascial closure and those with planned ventral hernia have 
similar rates of return to usual activity.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal wall hernia; damage control laparotomy; injury; laparotomy; 
EMTREE MEDICAL INDEX TERMS
  abdominal infection; abdominal wall closure; adult; article; female; follow up; hospitalization; human; injury scale; intestine fistula; major clinical study; male; mortality; mortality rate; outcome assessment; penetrating trauma; priority journal; recurrent disease; retrospective study; return to work; spinal cord injury; survival; survivor; tracheostomy; 
EMBASE CLASSIFICATIONS
  Gastroenterology (48)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015940724
MEDLINE PMID
  25877693 (http://www.ncbi.nlm.nih.gov/pubmed/25877693)
PUI
  L603879531
DOI
  10.1007/s10029-015-1377-2
FULL TEXT LINK
  http://dx.doi.org/10.1007/s10029-015-1377-2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=12489204&id=doi:10.1007%2Fs10029-015-1377-2&atitle=Planned+ventral+hernia+following+damage+control+laparotomy+in+trauma%3A+an+added+year+of+recovery+but+equal+long-term+outcome&stitle=Hernia&title=Hernia&volume=20&issue=2&spage=231&epage=238&aulast=Zosa&aufirst=B.M.&auinit=B.M.&aufull=Zosa+B.M.&coden=HERNF&isbn=&pages=231-238&date=2016&auinit1=B&auinitm=M
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 280
TITLE
  Relationship between quality-of-life after 1-year follow-up and severity of 
traumatic brain injury assessed by computerized tomography
AUTHOR NAMES
  Prieto-Palomino M.A.; Curiel-Balsera E.; Arias-Verdu M.D.; Der Kroft M.D.-V.; Munõz-Lopez A.; Fernandez-Ortega J.F.; Quesada-Garcia G.; Sanchez-Cantalejo E.; Rivera-Fernandez R.
AUTHOR ADDRESSES
  (Prieto-Palomino M.A.; Curiel-Balsera E.; Arias-Verdu M.D., 
lolaverdu@hotmail.com; Munõz-Lopez A.; Fernandez-Ortega J.F.; Quesada-Garcia 
G.) IBIMA, Intensive Care Unit, Hospital Regional Universitario Carlos Haya, 
Malaga, Spain.
(Der Kroft M.D.-V.) Intensive Care Unit, Hospital Comarcal de la Axarquia, 
Velez-Malaga, Malaga, Spain.
(Sanchez-Cantalejo E.) Escuela Andaluza de Salud Publica, Instituto de 
Investigacion Biosanitaria de Granada, CIBERESP, Madrid, Spain.
(Rivera-Fernandez R.) Intensive Care Unit, Hospital de la Serrania de Ronda, 
Malaga, Spain.
CORRESPONDENCE ADDRESS
  M.D. Arias-Verdu, IBIMA, Intensive Care Unit, Hospital Regional 
Universitario Carlos Haya, Malaga, Spain. Email: lolaverdu@hotmail.com
AiP/IP ENTRY DATE
  2016-05-05
FULL RECORD ENTRY DATE
  2016-05-20
SOURCE
  Brain Injury (2016) 30:4 (441-451). Date of Publication: 20 Mar 2016
VOLUME
  30
ISSUE
  4
FIRST PAGE
  441
LAST PAGE
  451
DATE OF PUBLICATION
  20 Mar 2016
ISSN
  1362-301X (electronic)
  0269-9052
BOOK PUBLISHER
  Taylor and Francis Ltd, healthcare.enquiries@informa.com
ABSTRACT
  This paper studies the relationship between computed tomography (CT) scan on 
admission, according to Marshall's tomographic classification, and 
quality-of-life (QoL) after 1 year in patients admitted to the Intensive 
Care Unit (ICU) with traumatic brain injury (TBI). Methods: This study used 
validated scales including the Glasgow Outcome Scale and the PAECC (Project 
for the Epidemiologic Analysis of Critical Care Patients) QoL questionnaire. 
Results: We enrolled 531 patients. After 1 year, 171 patients (32.2%) had 
died (missing data = 6.6%). Good recovery was seen in 22.7% of the patients, 
while 20% presented moderate disability. The PAECC score after 1 year was 
9.43 ± 8.72 points (high deterioration). Patients with diffuse injury I had 
a mean of 5.08 points vs 7.82 in those with diffuse injury II, 11.76 in 
those with diffuse injury III and 19.29 in those with diffuse injury IV (p > 
0.001). Multivariate analysis found that QoL after 1 year was associated 
with CT Marshall classification, depth of coma, age, length of stay, spinal 
injury and tracheostomy. Conclusions: Patients with TBI had a high mortality 
rate 1 year after admission, deterioration in QoL and significant impairment 
of functional status, although more than 40% were normal or self-sufficient. 
QoL after 1 year was strongly related to cranial CT findings on admission.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  computer assisted tomography; quality of life; traumatic brain injury (disease management); 
EMTREE MEDICAL INDEX TERMS
  adult; age; article; coma; convalescence; disability; disease classification; female; follow up; Glasgow outcome scale; hospital admission; human; injury severity; intensive care; length of stay; major clinical study; male; Marshall classification; middle aged; mortality rate; Project for the Epidemiologic Analysis of Critical Care Patients; prospective study; quality of life assessment; spine injury; tracheostomy; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160335869
MEDLINE PMID
  26963562 (http://www.ncbi.nlm.nih.gov/pubmed/26963562)
PUI
  L610170230
DOI
  10.3109/02699052.2016.1141434
FULL TEXT LINK
  http://dx.doi.org/10.3109/02699052.2016.1141434
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1362301X&id=doi:10.3109%2F02699052.2016.1141434&atitle=Relationship+between+quality-of-life+after+1-year+follow-up+and+severity+of+traumatic+brain+injury+assessed+by+computerized+tomography&stitle=Brain+Inj.&title=Brain+Injury&volume=30&issue=4&spage=441&epage=451&aulast=Prieto-Palomino&aufirst=Miguel+Angel&auinit=M.A.&aufull=Prieto-Palomino+M.A.&coden=BRAIE&isbn=&pages=441-451&date=2016&auinit1=M&auinitm=A
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 281
TITLE
  Effect of Intrathecal Baclofen on Delayed-Onset Paroxysmal Dystonia due to 
Compression Injury Resulting from Congenital and Progressive Spinal Bone 
Deformities in Chondrodysplasia Punctata
AUTHOR NAMES
  Okazaki T.; Saito Y.; Ueda R.; Sugihara S.; Tamasaki A.; Nishimura Y.; Ohno K.; Togawa M.; Ohno T.; Horie A.; Honda M.; Takenaka A.; Nagashima H.; Maegaki Y.
AUTHOR ADDRESSES
  (Okazaki T., t-okazaki@med.tottori-u.ac.jp; Saito Y.; Ueda R.; Sugihara S.; 
Tamasaki A.; Nishimura Y.; Ohno K.; Togawa M.; Maegaki Y.) Division of Child 
Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori 
University, 36-1 Nishi-cho, Yonago, Tottori, Japan.
(Togawa M.) Department of Pediatrics, Tottori Prefectural Central Hospital, 
Tottori, Japan.
(Ohno T.) Western Shimane Medical and Welfare Center for the Disabled, 
Shimane, Japan.
(Horie A.) Department of Pediatrics, Shimane University, Faculty of 
Medicine, Shimane, Japan.
(Honda M.; Takenaka A.) Division of Urology, Department of Surgery, Tottori 
University, Faculty of Medicine, Yonago, Japan.
(Nagashima H.) Department of Orthopedic Surgery, Tottori University, Yonago, 
Tottori, Japan.
CORRESPONDENCE ADDRESS
  T. Okazaki, Division of Child Neurology, Institute of Neurological Sciences, 
Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 
Japan. Email: t-okazaki@med.tottori-u.ac.jp
AiP/IP ENTRY DATE
  2016-01-13
FULL RECORD ENTRY DATE
  2016-04-13
SOURCE
  Pediatric Neurology (2016) 56 (80-85). Date of Publication: 1 Mar 2016
VOLUME
  56
FIRST PAGE
  80
LAST PAGE
  85
DATE OF PUBLICATION
  1 Mar 2016
ISSN
  1873-5150 (electronic)
  0887-8994
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background Dystonia due to spinal lesions in adult patients is characterized 
by the provocation and/or amelioration of the spasm by somatosensory 
stimulation with a sensory trick. Patient Description An infant with 
brachytelephalangic chondrodysplasia punctata developed flaccid tetraplegia 
due to cervical cord compression resulting from congenital atlantoaxial 
dislocation. Episodic, tonic extension of the extremities, neck, and trunk 
had appeared daily since age two years and was often provoked by tactile 
stimulation. Although decompression surgery was performed at age three 
years, progressive spinal deformity resulted in the aggravation of episodic 
dystonia thereafter, lasting for hours. Foot dorsiflexion and wearing a 
truncal brace for scoliosis inhibited these spasms. Intrathecal baclofen 
bolus injection transiently ameliorated the paroxysmal dystonia and 
detrusor-sphincter dyssynergia in the lower urinary tract. Conclusion 
Paroxysmal dystonia is unusual in children with spinal cord lesions; 
however, it should be recognized for appropriate individualized clinical 
management.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  baclofen (drug administration, drug therapy, intrathecal drug 
administration); 
EMTREE DRUG INDEX TERMS
  eperisone (drug therapy); phenobarbital (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial dislocation (congenital disorder); cervical cord compression; chondrodysplasia punctata (congenital disorder); paroxysmal dystonia (drug therapy, drug therapy); spinal cord compression; 
EMTREE MEDICAL INDEX TERMS
  article; aspiration pneumonia; bolus injection; brace; case report; child; decompression surgery; detrusor dyssynergia; disease course; drug effect; dyspnea; flaccid paralysis; gastrostomy; human; lower urinary tract symptom; male; muscle hypotonia; neurogenic bladder; neuroimaging; nuclear magnetic resonance imaging; positive end expiratory pressure; preschool child; priority journal; quadriplegia; recurrent aspiration; scoliosis; sleep disordered breathing; somatosensory evoked potential; stomach fundoplication; tactile stimulation; tracheotomy; 
CAS REGISTRY NUMBERS
  baclofen (1134-47-0)
  eperisone (56839-43-1, 64840-90-0)
  phenobarbital (50-06-6, 57-30-7, 8028-68-0)
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160024524
MEDLINE PMID
  26777981 (http://www.ncbi.nlm.nih.gov/pubmed/26777981)
PUI
  L607640387
DOI
  10.1016/j.pediatrneurol.2015.11.011
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pediatrneurol.2015.11.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18735150&id=doi:10.1016%2Fj.pediatrneurol.2015.11.011&atitle=Effect+of+Intrathecal+Baclofen+on+Delayed-Onset+Paroxysmal+Dystonia+due+to+Compression+Injury+Resulting+from+Congenital+and+Progressive+Spinal+Bone+Deformities+in+Chondrodysplasia+Punctata&stitle=Pediatr.+Neurol.&title=Pediatric+Neurology&volume=56&issue=&spage=80&epage=85&aulast=Okazaki&aufirst=Tetsuya&auinit=T.&aufull=Okazaki+T.&coden=PNEUE&isbn=&pages=80-85&date=2016&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 282
TITLE
  Hybrid lateral mass screw sublaminar wire construct: A salvage technique for 
posterior cervical fixation in pediatric spine surgery
AUTHOR NAMES
  Quinn J.C.; Patel N.V.; Tyagi R.
AUTHOR ADDRESSES
  (Quinn J.C.; Patel N.V., patel236@njms.rutgers.edu) Department of 
Neurological Surgery, Rutgers, New Jersey Medical School, Newark, United 
States.
(Patel N.V., patel236@njms.rutgers.edu; Tyagi R.) Division of Neurosurgery, 
Rutgers, Robert Wood Johnson Medical School, 125 Paterson Street, New 
Brunswick, United States.
CORRESPONDENCE ADDRESS
  N.V. Patel, Department of Neurological Surgery, Rutgers, New Jersey Medical 
School, Newark, United States. Email: patel236@njms.rutgers.edu
AiP/IP ENTRY DATE
  2016-02-08
FULL RECORD ENTRY DATE
  2016-02-11
SOURCE
  Journal of Clinical Neuroscience (2016) 25 (118-121). Date of Publication: 1 
Mar 2016
VOLUME
  25
FIRST PAGE
  118
LAST PAGE
  121
DATE OF PUBLICATION
  1 Mar 2016
ISSN
  1532-2653 (electronic)
  0967-5868
BOOK PUBLISHER
  Churchill Livingstone
ABSTRACT
  We present a novel salvage technique for pediatric subaxial cervical spine 
fusion in which lateral mass screw fixation was not possible due to anatomic 
constraints. The case presentation details a 4-year-old patient with C5-C6 
flexion/distraction injury with bilateral jumped facets. Posterior cervical 
fixation was attempted; however, lateral mass fracture occurred during 
placement of screws. Using a wire-screw construct, an attempt was made to 
provide stable fixation. The patient was followed post-operatively for 
assessment of outcomes. After the patient had progressive kyphosis following 
initial closed reduction and external orthosis, internal reduction with 
fusion/fixation was performed. Lateral mass fracture occurred during 
placement of lateral mass screws. After placement of a sub-laminar 
wire-lateral mass screw construct, intra-operative evaluation determined 
stability. Post-operatively, the procedure resulted in stable fixation with 
evidence of bony fusion on follow-up. Pediatric subaxial cervical spine 
instrumentation provides rigid fixation however is technically difficult due 
to anatomic and instrumentation related constraints. In the presented 
patient, the wire-screw construct resulted in stable fixation and bony 
fusion on follow-up. A modified sublaminar wire-lateral mass screw construct 
is an example of a salvage technique that provides immediate stability in 
the event of instrumentation related lateral mass fracture.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone screw; cervical spine injury (diagnosis, surgery, therapy); posterior spine fusion; surgical technique; 
EMTREE MEDICAL INDEX TERMS
  article; atlantoaxial subluxation; brace; brain hypoxia; case report; cervical collar; cervical spine fracture (diagnosis, surgery, therapy); cervical spine radiography; child; computer assisted tomography; conservative treatment; disease course; disease severity; fluoroscopy; follow up; fracture reduction; hospital discharge; hospitalization; human; kyphosis; male; peroperative care; postoperative period; preschool child; priority journal; rehabilitation care; spinal cord injury; spine instability (surgery); spine stabilization; stomach tube; surgical wire; tracheostomy; traffic accident; visual stimulation; 
DEVICE TRADE NAMES
  Mountaineer  , United StatesDe Puy

DEVICE MANUFACTURERS
   (United States)De Puy
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160092906
MEDLINE PMID
  26541322 (http://www.ncbi.nlm.nih.gov/pubmed/26541322)
PUI
  L608046050
DOI
  10.1016/j.jocn.2015.09.012
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jocn.2015.09.012
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15322653&id=doi:10.1016%2Fj.jocn.2015.09.012&atitle=Hybrid+lateral+mass+screw+sublaminar+wire+construct%3A+A+salvage+technique+for+posterior+cervical+fixation+in+pediatric+spine+surgery&stitle=J.+Clin.+Neurosci.&title=Journal+of+Clinical+Neuroscience&volume=25&issue=&spage=118&epage=121&aulast=Quinn&aufirst=John+C.&auinit=J.C.&aufull=Quinn+J.C.&coden=JCNUE&isbn=&pages=118-121&date=2016&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 283
TITLE
  Thoracic endovascular repair first for extensive aortic disease: The staged 
hybrid approach
AUTHOR NAMES
  Vivacqua A.; Idrees J.J.; Johnston D.R.; Soltesz E.G.; Svensson L.G.; Roselli E.E.
AUTHOR ADDRESSES
  (Vivacqua A.; Idrees J.J.; Johnston D.R.; Soltesz E.G.; Svensson L.G.; 
Roselli E.E., roselle@ccf.org) The Aortic Center, Heart and Vascular 
Institute Cleveland Clinic, Cleveland, United States.
CORRESPONDENCE ADDRESS
  E.E. Roselli, Department of Thoracic and Cardiovascular Surgery, Cleveland 
Clinic, 9500 Euclid Avenue/Desk J4-1, Cleveland, United States. Email: 
roselle@ccf.org
AiP/IP ENTRY DATE
  2016-04-19
FULL RECORD ENTRY DATE
  2016-05-03
SOURCE
  European Journal of Cardio-thoracic Surgery (2016) 49:3 (764-769). Date of 
Publication: 1 Mar 2016
VOLUME
  49
ISSUE
  3
FIRST PAGE
  764
LAST PAGE
  769
DATE OF PUBLICATION
  1 Mar 2016
ISSN
  1873-734X (electronic)
  1010-7940
BOOK PUBLISHER
  European Association for Cardio-Thoracic Surgery, info@eacts.co.uk
ABSTRACT
  OBJECTIVES: Repair of extensive aortic disease carries a significant risk of 
death and morbidity, the most feared complication being spinal cord 
ischaemia. Objectives of this study are to characterize patients, describe 
repair methods and assess feasibility and safety of hybrid staged repair for 
treatment of extensive aortic disease. METHODS: From to 2001 to 2013, 22 
patients underwent extensive aortic repair that included a thoracic 
endovascular aortic repair (TEVAR) first followed by an open completion 
repair extending through the visceral and infrarenal aorta for degenerative 
aneurysm and dissection. At the time of initial repair, all patients were 
deemed to be at a high risk for conventional open repair and had extensive 
disease. Indications for open completion included emergency failure of TEVAR 
(n = 3), early two-stage approach (n = 6) and delayed disease progression 
after TEVAR (n = 13). The median interval between stages was 6.5 months. The 
mean age was 56 ± 14 years, 5 patients had connective tissue disorder and 
the mean maximum aortic diameter was 58 ± 16 mm preoperatively. RESULTS: 
There was no death or major complication after initial TEVAR, but the 
operative mortality rate was 9% (n = 2) after the open procedure. One of 
these patients died from intraoperative myocardial infarction during 
emergency repair, and the other had disseminated intravascular coagulation 
during delayed repair for disease progression after TEVAR. Other 
complications included paralysis in 1 (4.5%), tracheostomy in 2 (9%) and 
dialysis in 1 (4.5%), and there was 1 reoperation for bleeding (4.5%). The 
median follow-up was 37 (range 3.3-93) months and there were no late deaths. 
There were four late reoperations for proximal disease progression leading 
to Type 1 endoleak (n = 2), Type A dissection (n = 1) and root aneurysm (n = 
1).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic disease (surgery); endovascular aneurysm repair; hybrid staged repair; 
EMTREE MEDICAL INDEX TERMS
  adult; aortic reconstruction; article; cardiac patient; cardiovascular risk; clinical article; descending aortic surgery; dialysis; disease course; disseminated intravascular clotting (complication); female; follow up; heart death; heart infarction (complication, surgery); human; male; middle aged; morbidity; outcome assessment; paralysis (complication); postoperative hemorrhage (complication); priority journal; reoperation; spinal cord ischemia; surgical mortality; surgical patient; surgical technique; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160294419
MEDLINE PMID
  26276838 (http://www.ncbi.nlm.nih.gov/pubmed/26276838)
PUI
  L609834943
DOI
  10.1093/ejcts/ezv274
FULL TEXT LINK
  http://dx.doi.org/10.1093/ejcts/ezv274
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1873734X&id=doi:10.1093%2Fejcts%2Fezv274&atitle=Thoracic+endovascular+repair+first+for+extensive+aortic+disease%3A+The+staged+hybrid+approach&stitle=Eur.+J.+Cardio-thorac.+Surg.&title=European+Journal+of+Cardio-thoracic+Surgery&volume=49&issue=3&spage=764&epage=769&aulast=Vivacqua&aufirst=Alessandro&auinit=A.&aufull=Vivacqua+A.&coden=EJCSE&isbn=&pages=764-769&date=2016&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 284
TITLE
  Acute spinal cord injury
AUTHOR NAMES
  Kirke Rogers W.; Todd M.
AUTHOR ADDRESSES
  (Kirke Rogers W., william-k-rogers@uiowa.edu; Todd M., 
michael-todd@uiowa.edu) Department of Anesthesia, University of Iowa 
Hospital and Clinics, 200 Hawkins Drive, Iowa City, United States.
CORRESPONDENCE ADDRESS
  W. Kirke Rogers, Department of Anesthesia, University of Iowa Hospital and 
Clinics, 200 Hawkins Drive, Iowa City, United States. Email: 
william-k-rogers@uiowa.edu
AiP/IP ENTRY DATE
  2016-03-22
FULL RECORD ENTRY DATE
  2016-05-19
SOURCE
  Best Practice and Research: Clinical Anaesthesiology (2016) 30:1 (27-39). 
Date of Publication: 1 Mar 2016
VOLUME
  30
ISSUE
  1
FIRST PAGE
  27
LAST PAGE
  39
DATE OF PUBLICATION
  1 Mar 2016
ISSN
  1532-169X (electronic)
  1521-6896
BOOK PUBLISHER
  Bailliere Tindall Ltd
ABSTRACT
  Acute spinal cord injury (SCI) is a devastating event with high mortality 
and, among survivors, a high degree of morbidity due to both motor and 
sensory deficits. The damage that occurs with a SCI is recognized to be 
pathophysiologically biphasic: the initial insult to neural tissue can be 
followed by a secondary process of progressive ischemia that may worsen the 
severity of dysfunction. The extent of this secondary insult is potentially 
modifiable, and a variety of interventions have been studied in an attempt 
to improve motor and sensory outcomes. What follows is a brief review of 
some such procedural and pharmacologic interventions, including early 
decompressive surgery, use of methylprednisolone, and blood pressure and 
respiratory management, which have been proposed to improve outcomes after 
SCI.
EMTREE DRUG INDEX TERMS
  ganglioside GM1 (drug therapy); methylprednisolone (drug therapy); naloxone (drug therapy); protirelin (drug therapy); tirilazad (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute disease (drug therapy, drug therapy, surgery, therapy); acute spinal cord injury (drug therapy, drug therapy, surgery, therapy); spinal cord injury (drug therapy, drug therapy, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; blood pressure; decompression surgery; deep vein thrombosis; human; hypotension; induced hypothermia; intensive care unit; Medline; nonhuman; priority journal; thrombosis prevention; tracheostomy; 
CAS REGISTRY NUMBERS
  ganglioside GM1 (37758-47-7)
  methylprednisolone (6923-42-8, 83-43-2)
  naloxone (357-08-4, 465-65-6)
  protirelin (24305-27-9)
  tirilazad (110101-66-1, 110101-67-2, 111793-42-1)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160220823
MEDLINE PMID
  27036601 (http://www.ncbi.nlm.nih.gov/pubmed/27036601)
PUI
  L609073428
DOI
  10.1016/j.bpa.2015.11.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.bpa.2015.11.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1532169X&id=doi:10.1016%2Fj.bpa.2015.11.003&atitle=Acute+spinal+cord+injury&stitle=Best+Pract.+Res.+Clin.+Anaesthesiol.&title=Best+Practice+and+Research%3A+Clinical+Anaesthesiology&volume=30&issue=1&spage=27&epage=39&aulast=Kirke+Rogers&aufirst=&auinit=W.&aufull=Kirke+Rogers+W.&coden=BPRCD&isbn=&pages=27-39&date=2016&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 285
TITLE
  Multi-center analysis of operative safety of surgery in patients with 
amyotrophic lateral sclerosis: The diaphragm pacing experience
AUTHOR NAMES
  Onders R.; Carlin A.; Dunkin B.; Jossart G.; Marohn M.; Menegaux F.; Morton J.; Smith C.D.
AUTHOR ADDRESSES
  (Onders R.) University Hospitals Case Medical Center, United States.
(Carlin A.) Henry Ford health System, United States.
(Dunkin B.) Methodist Hospital, United States.
(Jossart G.) California Pacific Medical Center, United States.
(Marohn M.) John Hopkins, United States.
(Menegaux F.) Pitie Hospital, United States.
(Morton J.) Stanford School of Medicine, United States.
(Smith C.D.) Mayo Clinic, United States.
CORRESPONDENCE ADDRESS
  R. Onders, University Hospitals Case Medical Center, United States.
FULL RECORD ENTRY DATE
  2016-04-13
SOURCE
  Surgical Endoscopy and Other Interventional Techniques (2016) 30 SUPPL. 1 
(S317). Date of Publication: March 2016
VOLUME
  30
FIRST PAGE
  S317
DATE OF PUBLICATION
  March 2016
CONFERENCE NAME
  2016 Scientific Session of the Society of American Gastrointestinal and 
Endoscopic Surgeons, SAGES 2016
CONFERENCE LOCATION
  Boston, MA, United States
CONFERENCE DATE
  2016-03-16 to 2016-03-19
ISSN
  0930-2794
BOOK PUBLISHER
  Springer New York LLC
ABSTRACT
  Introduction: With the growing prevalence of patients with amyotrophic 
lateral sclerosis (ALS) there is a need to describe and analyze the correct 
perioperative management. ALS is a progressive neurodegenerative disease 
that has devastating effects to respiratory muscles resulting in respiratory 
failure death in 80 % of patients. Diaphragm pacing (DP) replaces 
ventilators in spinal cord injury patients and delays death and tracheostomy 
in ALS patients. This report outlines the peri-operative outcomes to 90 days 
for patients in a multicenter pivotal FDA trial of DP in ALS. Methods: The 
study was conducted under an investigational device exemption (IDE G040142, 
clinicaltrials.gov NCT00420719) from the U.S. FDA and IRB approval. Patients 
underwent three pre-operative neurophysiologic assessments to quantify 
diaphragm function. Inclusion criteria included chronic hypoventilation with 
intact diaphragm motor units to stimulate. A standardized ALS functional 
rating scale (ALSFSR-R) was completed serially pre and post-operatively. 
Patients underwent general anesthesia with no paralytics with laparoscopic 
implantation of the diaphragm pacing electrodes in each hemi-diaphragm. 
Post-operative ALSFSR-R results and complications were noted. Data were 
analyzed with Stata 13.0. Results: At eight worldwide sites, 107 patients 
went to surgery with 106 patients successfully being implanted with DP. One 
patient had a reaction to anesthesia requiring cancellation of surgery. 
Twenty-eight patients received a simultaneous percutaneous gastrostomy tube 
(PEG). There were 73 males and 36 females with a median age of 57.9 years 
(range 32-76). The mean lead-in time was 2.7 ± 0.6 months from consent to 
implant. The mean post-op period was 3.8 ± 1.0 months from implant to data 
collection. There were no deaths within 30 days post implant. Three in the 
non-PEG group, died within 90 days. The median ALSFRS-R score at implant was 
28 points (on the 48 point scale). The lead-in period rate of decline was 
compared on a paired, patient-by-patient, basis to the rate of decline for 
the post-operative treatment period. There was no significant change in the 
rate of decline of this functional scale (lead-in slope -0.80 vs post-op 
slope -0.73 with p value = 0.50). There were 4 serious adverse effects: 2 
capnothorax, 1 respiratory failure following complications from surgery 
(dislodgement of gastrostomy); and 1 post-operative chest pain. Conclusion: 
There was no degradation in function for ALS patients undergoing surgical 
procedures when no paralytics are used and DP is placed. The diagnosis of 
ALS should not prevent a patient from being considered for a surgical 
procedure when necessary and to improve their quality of life.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; amyotrophic lateral sclerosis; diaphragm; human; patient; safety; society; surgeon; surgery; 
EMTREE MEDICAL INDEX TERMS
  adverse drug reaction; anesthesia; breathing muscle; death; degenerative disease; devices; diagnosis; electrode; female; Food and Drug Administration; gastrostomy; general anesthesia; hypoventilation; implant; implantation; information processing; male; motor unit; prevalence; quality of life; rating scale; respiratory failure; spinal cord injury; statistical significance; stomach tube; surgical technique; thorax pain; tracheostomy; United States; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72236377
DOI
  10.1007/s00464-016-4772-6
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00464-016-4772-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09302794&id=doi:10.1007%2Fs00464-016-4772-6&atitle=Multi-center+analysis+of+operative+safety+of+surgery+in+patients+with+amyotrophic+lateral+sclerosis%3A+The+diaphragm+pacing+experience&stitle=Surg.+Endosc.+Interv.+Tech.&title=Surgical+Endoscopy+and+Other+Interventional+Techniques&volume=30&issue=&spage=S317&epage=&aulast=Onders&aufirst=Raymond&auinit=R.&aufull=Onders+R.&coden=&isbn=&pages=S317-&date=2016&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 286
TITLE
  Spinal muscular atrophy with respiratory distress type 1 (SMARD1): Report of 
a Spanish case with extended clinicopathological follow-up
AUTHOR NAMES
  Millan B.S.; Fernandez J.M.; Navarro C.; Reparaz A.; Teijeira S.
AUTHOR ADDRESSES
  (Millan B.S.; Navarro C.; Teijeira S., susana.teijeira.bautista@sergas.es) 
Department of Pathology, Vigo, Spain.
(Fernandez J.M.) Department of Clinical Neurophysiology, Vigo, Spain.
(Reparaz A.) Neonatal Intensive Care Unit, Complexo Hospitalario 
Universitario de Vigo (CHUVI), Vigo, Spain.
(Millan B.S.; Fernandez J.M.; Navarro C.; Teijeira S., 
susana.teijeira.bautista@sergas.es) Institute of Biomedical Research of 
Ourense Pontevedra Vigo (IBI), Vigo, Spain.
CORRESPONDENCE ADDRESS
  S. Teijeira, Institute of Biomedical Research of Ourense Pontevedra Vigo 
(IBI), Complexo Hospitalario, Universitario de Vigo (CHUVI), Biomedical 
Research Unit, Hospital Álvaro Cunqueiro, Vigo, Spain. Email: 
susana.teijeira.bautista@sergas.es
AiP/IP ENTRY DATE
  2016-04-08
FULL RECORD ENTRY DATE
  2016-04-21
SOURCE
  Clinical Neuropathology (2016) 35:2 (58-65). Date of Publication: 1 Mar 2016
VOLUME
  35
ISSUE
  2
FIRST PAGE
  58
LAST PAGE
  65
DATE OF PUBLICATION
  1 Mar 2016
ISSN
  0722-5091
BOOK PUBLISHER
  Dustri-Verlag Dr. Karl Feistle, Bajuwarenring 4, Oberhaching, Germany. 
marina.rottner@dustri.de
ABSTRACT
  Background: Spinal muscular atrophy with respiratory distress type 1 
(SMARD1) is a clinically and genetically distinct and uncommon variant of 
SMA that results from irreversible degeneration of α-motor neurons in the 
anterior horns of the spinal cord and in ganglion cells on the spinal root 
ganglia. Aims: To describe the clinical, electrophysiological, 
neuropathological, and genetic findings, at different stages from birth to 
death, of a Spanish child diagnosed with SMARD1. Patient and methods: We 
report the case of a 3-monthold girl with severe respiratory insufficiency 
and, later, intense hypotonia. Paraclinical tests included biochemistry, 
chest X-ray, and electrophysiological studies, among others. Muscle and 
nerve biopsies were performed at 5 and 10 months and studied under light and 
electron microscopy. Post-mortem examination and genetic investigations were 
performed. Results: Pre- and post-mortem histopathological findings 
demonstrated the disease progression over time. Muscle biopsy at 5 months of 
age was normal, however a marked neurogenic atrophy was present in 
post-mortem samples. Peripheral motor and sensory nerves were severely 
involved likely due to a primary axonal disorder. Automatic sequencing of 
IGHMBP2 revealed a compound heterozygous mutation. Conclusions: The 
diagnosis of SMARD1 should be considered in children with early respiratory 
insufficiency or in cases of atypical SMA. Direct sequencing of the IGHMBP2 
gene should be performed.
EMTREE DRUG INDEX TERMS
  binding protein (endogenous compound); corticosteroid (drug therapy); immunoglobulin mu binding protein 2 (endogenous compound); oxygen; unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory distress (diagnosis, etiology); spinal muscular atrophy (diagnosis, etiology); spinal muscular atrophy with respiratory distress type 1 (diagnosis, 
etiology); 
EMTREE MEDICAL INDEX TERMS
  areflexia; article; artificial ventilation; autopsy; bronchiolitis (drug therapy, therapy); case report; clubfoot (congenital disorder); corticosteroid therapy; female; gastrostomy; gene mutation; heart arrhythmia; human; hypoventilation; infant; limb weakness; lung auscultation; lung infection; muscle hypotonia; neurogenic bladder; oxygen therapy; pleura effusion; priority journal; recurrent infection; respiratory failure; tendon contracture; thorax radiography; tracheostomy; urinary tract infection; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160267257
MEDLINE PMID
  26709713 (http://www.ncbi.nlm.nih.gov/pubmed/26709713)
PUI
  L609436320
DOI
  10.5414/NP300902
FULL TEXT LINK
  http://dx.doi.org/10.5414/NP300902
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07225091&id=doi:10.5414%2FNP300902&atitle=Spinal+muscular+atrophy+with+respiratory+distress+type+1+%28SMARD1%29%3A+Report+of+a+Spanish+case+with+extended+clinicopathological+follow-up&stitle=Clin.+Neuropathol.&title=Clinical+Neuropathology&volume=35&issue=2&spage=58&epage=65&aulast=Millan&aufirst=Beatriz+San&auinit=B.S.&aufull=Millan+B.S.&coden=CLNPD&isbn=&pages=58-65&date=2016&auinit1=B&auinitm=S
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 287
TITLE
  Complete Transection of the Cervical Trachea due to Blunt Trauma: Report of 
a Case
AUTHOR NAMES
  Shimoyama T.
AUTHOR ADDRESSES
  (Shimoyama T.) Department of Thoracic Surgery, Yokohama City Minato Red 
Cross Hospital, Yokohama, Japan
FULL RECORD ENTRY DATE
  2016-08-19
SOURCE
  Kyobu geka. The Japanese journal of thoracic surgery (2016) 69:2 (164-167). 
Date of Publication: 1 Feb 2016
VOLUME
  69
ISSUE
  2
FIRST PAGE
  164
LAST PAGE
  167
DATE OF PUBLICATION
  1 Feb 2016
ISSN
  0021-5252
ABSTRACT
  We herein report a case of complete transection of the cervical trachea due 
to blunt trauma. A 50-year-old man was transported to our hospital because 
of blunt neck trauma. His body surface showed only slight bruising on the 
neck. However, he exhibited see-saw breathing, so we suspected upper airway 
injury. The patient was carefully intubated using a bronchofiberscope, 
revealing complete transection of the cervical trachea. Chest computed 
tomography demonstrated destruction of the cervical tracheal structure. The 
patient also had a cervical spinal cord injury;thus, we performed 
tracheoplasty after 3 days of hospitalization. A tracheostomy was necessary 
because of the cervical cord injury and paralysis of the bilateral recurrent 
nerve. The patient's postoperative course was uneventful.
EMTREE MEDICAL INDEX TERMS
  accident; case report; human; injuries; male; middle aged; neck injury (surgery); trachea; tracheostomy; 
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  27075162 (http://www.ncbi.nlm.nih.gov/pubmed/27075162)
PUI
  L611672433
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00215252&id=doi:&atitle=Complete+Transection+of+the+Cervical+Trachea+due+to+Blunt+Trauma%3A+Report+of+a+Case&stitle=Kyobu+Geka&title=Kyobu+geka.+The+Japanese+journal+of+thoracic+surgery&volume=69&issue=2&spage=164&epage=167&aulast=Shimoyama&aufirst=Takehiko&auinit=T.&aufull=Shimoyama+T.&coden=&isbn=&pages=164-167&date=2016&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2016 Medline is the source for the citation and abstract of this 
record.

RECORD 288
TITLE
  Proton beam radiation therapy results in significantly reduced toxicity 
compared with intensity-modulated radiation therapy for head and neck tumors 
that require ipsilateral radiation
AUTHOR NAMES
  Romesser P.B.; Cahlon O.; Scher E.; Zhou Y.; Berry S.L.; Rybkin A.; Sine K.M.; Tang S.; Sherman E.J.; Wong R.; Lee N.Y.
AUTHOR ADDRESSES
  (Romesser P.B.; Cahlon O.; Scher E.; Berry S.L.; Rybkin A.; Lee N.Y., 
leen2@mskcc.org) Department of Radiation Oncology, Memorial Sloan Kettering 
Cancer Center, New York, United States.
(Cahlon O.; Sine K.M.; Tang S.) ProCure Proton Therapy Center, Somerset, 
United States.
(Scher E.) Rowan University School of Osteopathic Medicine, Stratford, 
United States.
(Zhou Y.) Department of Medical Physics, Memorial Sloan Kettering Cancer 
Center, New York, United States.
(Sherman E.J.) Department of Medicine, Memorial Sloan Kettering Cancer 
Center, New York, United States.
(Wong R.) Department of Surgery, Memorial Sloan Kettering Cancer Center, New 
York, United States.
CORRESPONDENCE ADDRESS
  N.Y. Lee, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New 
York, United States. Email: leen2@mskcc.org
AiP/IP ENTRY DATE
  2016-02-11
FULL RECORD ENTRY DATE
  2016-03-30
SOURCE
  Radiotherapy and Oncology (2016) 118:2 (286-292). Date of Publication: 1 Feb 
2016
VOLUME
  118
ISSUE
  2
FIRST PAGE
  286
LAST PAGE
  292
DATE OF PUBLICATION
  1 Feb 2016
ISSN
  1879-0887 (electronic)
  0167-8140
BOOK PUBLISHER
  Elsevier Ireland Ltd
ABSTRACT
  Background As proton beam radiation therapy (PBRT) may allow greater normal 
tissue sparing when compared with intensity-modulated radiation therapy 
(IMRT), we compared the dosimetry and treatment-related toxicities between 
patients treated to the ipsilateral head and neck with either PBRT or IMRT. 
Methods Between 01/2011 and 03/2014, 41 consecutive patients underwent 
ipsilateral irradiation for major salivary gland cancer or cutaneous 
squamous cell carcinoma. The availability of PBRT, during this period, 
resulted in an immediate shift in practice from IMRT to PBRT, without any 
change in target delineation. Acute toxicities were assessed using the 
National Cancer Institute Common Terminology Criteria for Adverse Events 
version 4.0. Results Twenty-three (56.1%) patients were treated with IMRT 
and 18 (43.9%) with PBRT. The groups were balanced in terms of baseline, 
treatment, and target volume characteristics. IMRT plans had a greater 
median maximum brainstem (29.7 Gy vs. 0.62 Gy (RBE), P < 0.001), maximum 
spinal cord (36.3 Gy vs. 1.88 Gy (RBE), P < 0.001), mean oral cavity (20.6 
Gy vs. 0.94 Gy (RBE), P < 0.001), mean contralateral parotid (1.4 Gy vs. 0.0 
Gy (RBE), P < 0.001), and mean contralateral submandibular (4.1 Gy vs. 0.0 
Gy (RBE), P < 0.001) dose when compared to PBRT plans. PBRT had 
significantly lower rates of grade 2 or greater acute dysgeusia (5.6% vs. 
65.2%, P < 0.001), mucositis (16.7% vs. 52.2%, P = 0.019), and nausea (11.1% 
vs. 56.5%, P = 0.003). Conclusions The unique properties of PBRT allow 
greater normal tissue sparing without sacrificing target coverage when 
irradiating the ipsilateral head and neck. This dosimetric advantage 
seemingly translates into lower rates of acute treatment-related toxicity.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  head and neck cancer (radiotherapy); intensity modulated radiation therapy; proton radiation; radiation injury (complication); 
EMTREE MEDICAL INDEX TERMS
  brain stem; cancer size; clinical article; conference paper; dermatitis (complication); distant metastasis; distant metastasis free survival; dysgeusia (complication); dysphagia (complication); fatigue (complication); female; follow up; human; lymph vessel metastasis; male; mouth cavity; mucosa inflammation (complication); nausea (complication); overall survival; priority journal; progression free survival; salivary gland cancer (radiotherapy); skin carcinoma (radiotherapy); spinal cord; stomach tube; tracheostomy; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160105095
MEDLINE PMID
  26867969 (http://www.ncbi.nlm.nih.gov/pubmed/26867969)
PUI
  L608139795
DOI
  10.1016/j.radonc.2015.12.008
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.radonc.2015.12.008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18790887&id=doi:10.1016%2Fj.radonc.2015.12.008&atitle=Proton+beam+radiation+therapy+results+in+significantly+reduced+toxicity+compared+with+intensity-modulated+radiation+therapy+for+head+and+neck+tumors+that+require+ipsilateral+radiation&stitle=Radiother.+Oncol.&title=Radiotherapy+and+Oncology&volume=118&issue=2&spage=286&epage=292&aulast=Romesser&aufirst=Paul+B.&auinit=P.B.&aufull=Romesser+P.B.&coden=RAOND&isbn=&pages=286-292&date=2016&auinit1=P&auinitm=B
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 289
TITLE
  Airway management in laryngotracheal injuries from blunt neck trauma in 
children
AUTHOR NAMES
  Chatterjee D.; Agarwal R.; Bajaj L.; Teng S.N.; Prager J.D.
AUTHOR ADDRESSES
  (Chatterjee D., debnath.chatterjee@childrenscolorado.org) Department of 
Anesthesiology, Children's Hospital Colorado, University of Colorado, School 
of Medicine, 13123 East 16th Avenue, B090, Aurora, United States.
(Agarwal R.) Department of Anesthesiology, Lucile Packard Children's 
Hospital, Stanford University, Palo Alto, United States.
(Bajaj L.) Department of Emergency Medicine, Children's Hospital Colorado, 
University of Colorado, School of Medicine, Aurora, United States.
(Teng S.N.) Department of Anesthesiology, Ochsner Hospital for Children, New 
Orleans, United States.
(Prager J.D.) Department of Otolaryngology, Children's Hospital Colorado, 
University of Colorado, School of Medicine, Aurora, United States.
CORRESPONDENCE ADDRESS
  D. Chatterjee, Department of Anesthesiology, Children's Hospital Colorado, 
University of Colorado, School of Medicine, 13123 East 16th Avenue, B090, 
Aurora, United States. Email: debnath.chatterjee@childrenscolorado.org
AiP/IP ENTRY DATE
  2015-12-11
FULL RECORD ENTRY DATE
  2016-01-14
SOURCE
  Paediatric Anaesthesia (2016) 26:2 (132-138). Date of Publication: 1 Feb 
2016
VOLUME
  26
ISSUE
  2
FIRST PAGE
  132
LAST PAGE
  138
DATE OF PUBLICATION
  1 Feb 2016
ISSN
  1460-9592 (electronic)
  1155-5645
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
ABSTRACT
  Summary Pediatric laryngotracheal injuries from blunt neck trauma are 
extremely rare, but can be potentially catastrophic. Early diagnosis and 
skillful airway management is critical in avoiding significant morbidity and 
mortality associated with these cases. We present a case of a patient who 
suffered a complete tracheal transection and cervical spine fracture 
following a clothesline injury to the anterior neck. A review of the 
mechanisms of injury, clinical presentation, initial airway management, and 
anesthetic considerations in laryngotracheal injuries from blunt neck trauma 
in children are presented.
EMTREE DRUG INDEX TERMS
  fentanyl; midazolam; oxygen; rocuronium; sevoflurane (drug dose); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  blunt neck trauma; blunt trauma; laryngotracheal injury (surgery, therapy); larynx injury (surgery, therapy); neck injury; respiration control; trachea injury (surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  anesthesiological procedure; breathing; case report; cervical soft tissue; cervical spinal cord injury (diagnosis); cervical spinal fusion; chest tube; child; clinical feature; clothesline injury; computer assisted tomography; consciousness level; drug intermittent therapy; emergency care; end to end anastomosis; endotracheal tube; face mask; fiberoptic bronchoscopy; hemodynamics; human; intensive care; intubation; laryngoscopy; male; nuclear magnetic resonance imaging; oxygen saturation; patient transport; pneumothorax; positive end expiratory pressure; priority journal; rapid sequence induction; review; school child; skin bruising; soft tissue; subluxation; trachea reconstruction; tracheostomy; treatment outcome; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  midazolam (59467-70-8)
  oxygen (7782-44-7)
  rocuronium (119302-91-9)
  sevoflurane (28523-86-6)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20151005332
MEDLINE PMID
  26530711 (http://www.ncbi.nlm.nih.gov/pubmed/26530711)
PUI
  L607158013
DOI
  10.1111/pan.12791
FULL TEXT LINK
  http://dx.doi.org/10.1111/pan.12791
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14609592&id=doi:10.1111%2Fpan.12791&atitle=Airway+management+in+laryngotracheal+injuries+from+blunt+neck+trauma+in+children&stitle=Paediatr.+Anaesth.&title=Paediatric+Anaesthesia&volume=26&issue=2&spage=132&epage=138&aulast=Chatterjee&aufirst=Debnath&auinit=D.&aufull=Chatterjee+D.&coden=PAANF&isbn=&pages=132-138&date=2016&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 290
TITLE
  An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial 
and spinal tumors: A clinical exome sequencing study
AUTHOR NAMES
  Kansal R.; Li X.; Shen J.; Samuel D.; Laningham F.; Lee H.; Panigrahi G.B.; Shuen A.; Kantarci S.; Dorrani N.; Reiss J.; Shintaku P.; Deignan J.L.; Strom S.P.; Pearson C.E.; Vilain E.; Grody W.W.
AUTHOR ADDRESSES
  (Kansal R., rkansal@hmc.psu.edu; Li X.; Lee H.; Kantarci S.; Reiss J.; 
Shintaku P.; Deignan J.L.; Strom S.P.; Grody W.W.) Pathology and Laboratory 
Medicine, University of California at Los Angeles, David Geffen School of 
Medicine, Los Angeles, United States.
(Shen J.) Medical Genetics and Metabolism, Valley Children's Hospital, 
Madera, United States.
(Samuel D.) Hematology/Oncology, Valley Children's Hospital, Madera, United 
States.
(Laningham F.) Department of Radiology, Valley Children's Hospital, Madera, 
United States.
(Panigrahi G.B.; Shuen A.; Pearson C.E.) The Hospital for Sick Children, 
Peter Gilgan Center for Research and Learning, Toronto, Canada.
(Shuen A.; Pearson C.E.) University of Toronto, Toronto, Canada.
(Dorrani N.; Vilain E.; Grody W.W.) Pediatrics, University of California at 
Los Angeles, David Geffen School of Medicine, Los Angeles, United States.
(Vilain E.; Grody W.W.) Human Genetics, University of California at Los 
Angeles, David Geffen School of Medicine, Los Angeles, United States.
CORRESPONDENCE ADDRESS
  R. Kansal, Department of Pathology and Laboratory Medicine, Penn State 
Milton S. Hershey Medical Center, Penn State College of Medicine, Mail Code 
H160, 500 University Drive, Hershey, United States. Email: 
rkansal@hmc.psu.edu
AiP/IP ENTRY DATE
  2015-12-11
FULL RECORD ENTRY DATE
  2016-01-27
SOURCE
  Genes Chromosomes and Cancer (2016) 55:2 (131-142). Date of Publication: 1 
Feb 2016
VOLUME
  55
ISSUE
  2
FIRST PAGE
  131
LAST PAGE
  142
DATE OF PUBLICATION
  1 Feb 2016
ISSN
  1098-2264 (electronic)
  1045-2257
BOOK PUBLISHER
  Blackwell Publishing Inc., subscrip@blackwellpub.com
ABSTRACT
  A 4-month-old male infant presented with severe developmental delay, 
cerebellar, brainstem, and cutaneous hemangiomas, bilateral tumors 
(vestibular, hypoglossal, cervical, and lumbar spinal), and few café-au-lait 
macules. Cerebellar and lumbar tumor biopsies revealed venous telangiectasia 
and intraneural perineuroma, respectively. Sequencing NF1, NF2, and RASA1 
(blood), and NF2 and SMARCB1 (lumbar biopsy) was negative for pathogenic 
mutations. Clinical exome sequencing (CES), requested for tumor syndrome 
diagnosis, revealed two heterozygous missense variants, c.359T>C;p.Phe120Ser 
and c.3344G>A;p.Arg1115Gln, in MLH3 (NM_001040108.1), a DNA mismatch repair 
(MMR) gene, Polyphen-predicted as probably damaging, and benign, 
respectively. Sanger sequencing confirmed both variants in the proband, and 
their absence in the mother; biological father unavailable. Both biopsied 
tissues were negative for microsatellite instability, and expressed MLH1, 
MSH2, PMS2, MSH6, and MLH3 immunohistochemically. Chromosomal microarray 
showed a 133 kb segment copy number duplication of 14q12 region encompassing 
FOXG1, possibly explaining the developmental delay, but not the tumors. The 
presence of MLH3 variants with multiple benign neural and vascular tumors 
was intriguing for their possible role in the pathogenesis of these 
neoplasms, which were suspicious for, but not diagnostic of, constitutional 
MMR deficiency. However, functional assays of non-neoplastic patient-derived 
cells showed intact base-base MMR function. Also, no previous FOXG1-aberrant 
patient was reported with tumors. We now report a 3-year-old 
FOXG1-duplicated patient with a yet undescribed tumor syndrome with clinical 
features of neurofibromatosis types I and II, where several validation 
studies could not ascertain the significance of CES findings; further 
studies may elucidate precise mechanisms and diagnosis for clinical 
management, including tumor surveillance.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  forkhead box g1 protein (endogenous compound); protein (endogenous compound); protein MLH3 (endogenous compound); transcription factor (endogenous compound); 
EMTREE DRUG INDEX TERMS
  DNA mismatch repair protein MSH2 (endogenous compound); etiracetam; mismatch repair protein PMS2 (endogenous compound); MutL protein homolog 1 (endogenous compound); protein MSH6 (endogenous compound); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  benign neoplasm; brain tumor; clinical exome sequencing; gene sequence; infant disease; multiple cancer; spinal cord tumor; 
EMTREE MEDICAL INDEX TERMS
  article; bilateral cancer; bilateral hearing loss; bone biopsy; brain biopsy; brain development; brain stem; cafe au lait spot; cancer diagnosis; case report; cerebellum disease; cerebellum injury; chromosomal instability; clinical feature; computer assisted tomography; copy number variation; cranial nerve; developmental disorder; differential diagnosis; DNA repair; DNA sequence; eye movement; face dysmorphia; facial nerve paralysis; family history; follow up; gastrostomy; gene duplication; human; human tissue; hypoglossal nerve disease; immunohistochemistry; infant; infant feeding; internal auditory canal; leg length inequality; lumbar spinal cord; male; medical history; microsatellite instability; mismatch repair; missense mutation; neurilemoma; neurofibromatosis type 1 (diagnosis); neurofibromatosis type 2 (diagnosis); neuroimaging; nuclear magnetic resonance imaging; pathogenesis; perineural invasion; peripheral lymphocyte; physical examination; priority journal; ptosis (eyelid); radiodiagnosis; recurrent aspiration; scoliosis; seizure; skin defect; skin hemangioma; telangiectasia; tracheostomy; tumor biopsy; vascular lesion; vascular tumor; vestibular disorder; vestibulocochlear nerve disease; vocal cord paralysis; 
CAS REGISTRY NUMBERS
  etiracetam (33996-58-6)
  protein (67254-75-5)
  protein MSH2 (153700-72-2)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20151002827
MEDLINE PMID
  26542077 (http://www.ncbi.nlm.nih.gov/pubmed/26542077)
PUI
  L607147386
DOI
  10.1002/gcc.22319
FULL TEXT LINK
  http://dx.doi.org/10.1002/gcc.22319
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10982264&id=doi:10.1002%2Fgcc.22319&atitle=An+infant+with+MLH3+variants%2C+FOXG1-duplication+and+multiple%2C+benign+cranial+and+spinal+tumors%3A+A+clinical+exome+sequencing+study&stitle=Genes+Chromosomes+Cancer&title=Genes+Chromosomes+and+Cancer&volume=55&issue=2&spage=131&epage=142&aulast=Kansal&aufirst=Rina&auinit=R.&aufull=Kansal+R.&coden=GCCAE&isbn=&pages=131-142&date=2016&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 291
TITLE
  A study of risk factors for tracheostomy in patients with a cervical spinal 
cord injury
AUTHOR NAMES
  Tanaka J.; Yugue I.; Shiba K.; Maeyama A.; Naito M.
AUTHOR ADDRESSES
  (Tanaka J., jt0120jt@gmail.com; Maeyama A.; Naito M.) Faculty of Medicine, 
Department of Orthopaedic Surgery, Fukuoka University, 7-45-1 Nanakuma, 
Jonan-ku, Fukuoka, Japan.
(Yugue I.; Shiba K.) Department of Orthopaedic Surgery, Spinal Injuries 
Center, Iizuka City, Fukuoka, Japan.
CORRESPONDENCE ADDRESS
  J. Tanaka, Faculty of Medicine, Department of Orthopaedic Surgery, Fukuoka 
University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Japan. Email: 
jt0120jt@gmail.com
AiP/IP ENTRY DATE
  2015-12-11
FULL RECORD ENTRY DATE
  2016-06-06
SOURCE
  Spine (2016) 41:9 (764-771). Date of Publication: 2016
VOLUME
  41
ISSUE
  9
FIRST PAGE
  764
LAST PAGE
  771
DATE OF PUBLICATION
  2016
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study Design. A retrospective, consecutive case series. Objective. To 
determine the risk factors for a tracheostomy in patients with a cervical 
spinal cord injury. Summary and Background Date. Respiratory status cannot 
be stabilized in patients with a cervical spinal cord injury (CSCI) for 
various reasons, so a number of these patients require longterm respiratory 
care and a tracheostomy. Various studies have described risk factors for a 
tracheostomy, but none have indicated a relationship between imaging 
assessment and the need for a tracheostomy. The current study used imaging 
assessment and other approaches to assess and examine the risk factors for a 
tracheostomy in patients with a CSCI. Methods. Subjects were 199 patients 
who were treated at the Spinal Injuries Center within 72 hours of a CSCI 
over 8-year period. Risk factors for a tracheostomy were retrospectively 
studied. Patients were assessed in terms of 10 items: age, sex, the presence 
of a vertebral fracture or dislocation, ASIA Impairment Scale, the 
neurological level of injury (NLI), PaO(2), PaCO(2), the level of injury on 
magnetic resonance imaging (MRI), the presence of hematoma-like changes (a 
hypointense core surrounded by a hyperintense rim in T2-weighted images) on 
MRI, and the Injury Severity Score. Items were analyzed multivariate 
logistic regression, and P<0.05 was considered to indicate a significant 
difference. Results. Twenty-three of the 199 patients required a 
tracheostomy, accounting for 11.6% of patients with a CSCI. Univariate 
analyses of the risk factors for tracheostomy revealed significant 
differences for six items: age, Injury Severity Score, presence of fracture 
or dislocation, ASIA Impairment Scale A, NLI C4 or above, and MRI scans 
revealing hematoma-like changes. Multivariate logistic regression analyses 
revealed significant differences in terms of two items: NLI C4 or above and 
MRI scans revealing hematoma-like changes. Thirty patients had both an NLI 
C4 or above and MRI scans revealing hematoma-like changes. Of these, 17 
(56.7%) required a tracheostomy. Conclusion. Patients with an NLI C4 or 
above and MRI scans revealing hematoma-like changes were likely to require a 
tracheostomy. An early tracheostomy should be considered for patients with 
both of these characteristics.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; risk factor; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; age; aged; American Spinal Injury Association impairment scale; article; blood carbon dioxide tension; blood oxygen tension; blunt trauma; female; hematoma; human; injury scale; major clinical study; male; nuclear magnetic resonance imaging; patient assessment; priority journal; retrospective study; spine fracture; vertebra dislocation; very elderly; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20151003393
MEDLINE PMID
  26630433 (http://www.ncbi.nlm.nih.gov/pubmed/26630433)
PUI
  L607151132
DOI
  10.1097/BRS.0000000000001317
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000001317
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000001317&atitle=A+study+of+risk+factors+for+tracheostomy+in+patients+with+a+cervical+spinal+cord+injury&stitle=Spine&title=Spine&volume=41&issue=9&spage=764&epage=771&aulast=Tanaka&aufirst=Jun&auinit=J.&aufull=Tanaka+J.&coden=SPIND&isbn=&pages=764-771&date=2016&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 292
TITLE
  Risk factors for dysphagia in acute cervical spinal cord injury
AUTHOR NAMES
  Hayashi T.; Sakai H.; Maeda T.; Shiba K.
AUTHOR ADDRESSES
  (Hayashi T.; Sakai H.; Maeda T.; Shiba K.)
CORRESPONDENCE ADDRESS
  T. Hayashi,
FULL RECORD ENTRY DATE
  2017-06-21
SOURCE
  Journal of Orthopaedic Research (2016) 34 Supplement 1. Date of Publication: 
2016
VOLUME
  34
DATE OF PUBLICATION
  2016
CONFERENCE NAME
  2016 Annual Meeting of the Orthopaedic Research Society
CONFERENCE LOCATION
  Orlando, FL, United States
CONFERENCE DATE
  2016-03-05 to 2016-03-08
ISSN
  1554-527X
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  INTRODUCTION: Dysphagia following traumatic cervical spinal cord injury 
(CSCI) is an under-recognized complication that can lead to aspiration 
pneumonia, which is a significant cause of morbidity and mortality. Several 
authors have investigated dysphagia associated with CSCI, however, risk 
factors for dysphagia are still not well understood. The objective of this 
study was to elucidate the incidence and risk factors of dysphagia in 
patients with acute CSCI. Methods: A total of 464 consecutive patients with 
traumatic cervical spinal injury with and without spinal cord damage were 
treated at our institute and were registered in a database from January 2007 
to December 2014. All patients underwent CT, MRI, and neurological 
examination on admission. We retrospectively selected 298 patients based on 
following criteria: (1) admission within 3 days following injury, (2) 
patients with paresis or paralysis, (3) patients without brain injury. 
Neurological impairment scale was evaluated according to ASIA impairment 
scale (AIS), and level of injury was identified using CT and MRI. We 
analyzed the factors postulated to increase the risk for dysphagia, 
including the patient's age, neurological impairment scale grade, level of 
injury tracheostomy, and operative treatment, using a multiple logistic 
regression model to compute odds ratios (ORs) and 95% confidence intervals 
(95% CI). The institutional review board at our institute approved this 
study. Results: 298 eligible patients (256 males and 42 females) with an 
average age 61.4±17.3 (range, 14-91 yr.) were identified during 8-year study 
period. 21 of 298 patients appeared to be suffering from dysphagia after 
CSCI (7.0%). All of them experienced evident aspiration and had to stop 
eating their meals due to aspiration. The neurological status revealed that 
13 of those patients were AIS A, 6 patients were AIS B, and 2 patients were 
AIS C. 12 of 21 patients (57.1%) received tracheostomy. Multivariable 
logistic regression analysis revealed that age > 72 years (OR: 2.97, 95% CI: 
1.01-9.02, p=0.04), AIS A or B (OR: 8.00, 95% CI: 1.92-54.7, p=0.003), 
presence of tracheostomy (OR: 13.8, 95% CI: 4.62-44.3, p<0.001) were 
significant risk factors (Table 1). Discussion: The incidence of dysphagia 
after acute CSCI was 7.0%. Old age, severe neurological impairment scale, 
and presence of tracheostomy may be at risk for dysphagia after acute CSCI. 
When treating CSCI, understanding the risk factors of dysphagia is important 
to prevent aspiration pneumonia. SIGNIFICANCE: By detecting the risk factors 
of dysphagia, the incidence of aspiration pneumonia would be decreased.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; dysphagia; risk factor; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; American Spinal Injury Association impairment scale; aspiration pneumonia; brain injury; confidence interval; data base; eating; female; human; institutional review; major clinical study; male; model; multivariate logistic regression analysis; neurologic examination; nuclear magnetic resonance imaging; odds ratio; paresis; prevention; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L616819884
DOI
  10.1002/jor.23247
FULL TEXT LINK
  http://dx.doi.org/10.1002/jor.23247
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1554527X&id=doi:10.1002%2Fjor.23247&atitle=Risk+factors+for+dysphagia+in+acute+cervical+spinal+cord+injury&stitle=J.+Orthop.+Res.&title=Journal+of+Orthopaedic+Research&volume=34&issue=&spage=&epage=&aulast=Hayashi&aufirst=Tetsuo&auinit=T.&aufull=Hayashi+T.&coden=&isbn=&pages=-&date=2016&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 293
TITLE
  Safety of aquatic therapy for adults with complex medical conditions among 
chronic spinal cord injury
AUTHOR NAMES
  Recio A.C.; Cabahug P.
AUTHOR ADDRESSES
  (Recio A.C.; Cabahug P.) Department of Physical Medicine and Rehabilitation, 
Johns Hopkins University, School of Medicine, Baltimore, United States.
(Recio A.C.; Cabahug P.) International Center for Spinal Cord Injury, Hugo 
W. Moser Research Institute at Kennedy Krieger Institute, Baltimore, United 
States.
CORRESPONDENCE ADDRESS
  A.C. Recio, Department of Physical Medicine and Rehabilitation, Johns 
Hopkins University, School of Medicine, Baltimore, United States.
FULL RECORD ENTRY DATE
  2017-08-21
SOURCE
  Journal of Spinal Cord Medicine (2016) 39:5 (568-569). Date of Publication: 
2016
VOLUME
  39
ISSUE
  5
FIRST PAGE
  568
LAST PAGE
  569
DATE OF PUBLICATION
  2016
CONFERENCE NAME
  Academy of Spinal Cord Injury Professionals Educational Conference 2016
CONFERENCE LOCATION
  Nashville, AR, United States
CONFERENCE DATE
  2016-09-04 to 2016-09-07
ISSN
  2045-7723
BOOK PUBLISHER
  Maney Publishing
ABSTRACT
  Objective: Demonstrate safety within aquatic environment for patients with 
spinal cord injury (SCI) with pressure ulcers, colostomy or ileostomy bags, 
supra pubic catheters, indwelling catheters, and tracheostomy tube, Describe 
aquatic interventions and task modifications for pressure ulcers, colostomy 
or ileostomy bags, supra pubic catheters, indwelling catheters, and 
tracheostomy tubes in adult patients with chronic spinal cord injury, and 
assess the impact of aquatic therapy on family and caregiver-reported 
quality of life. Design: Retrospective chart review Participants/methods: 
Data collected were obtained from medical charts after the patient was 
discharged from aquatic-based therapies. Relevant demographic, clinical and 
outcomes information were retrieved for entry in to this research. Inclusion 
criteria include patients 18 years old and older, and have a chronic (>1 
year) spinal cord injury (any neurological level, any AIS classification) 
who received treatment at Aquatics Department of Kennedy Krieger Institute. 
Results: Aquatic based restorative therapy in 100 patients with spinal cord 
injury was an effective therapy to produce significant improvements in a 
variety of endpoints including upper & lower extremity strength, Modified 
Ashworth Scale, 6-minute walking distance, and functional reach test. 
Patients with Stage 2 and 3 pressure ulcers required protection using 
OpSite. No maceration or worsening of the wound were noted. Those with 
colostomy bags required ostomy bag to be picture frame taped to clean, dry 
skin with waterproof dressing before pool session. Only one reported 
accident was noted which required the pool to be shocked with appropriate 
chemicals. No untoward medical complications were noted with the patient. 
Supra-pubic and indwelling catheters required them being secured to their 
body or floats. No incidence of catheter being pulled out was noted. 
Patients with tracheostomies required that they tolerate capping for a 
minimum of 4 hours. The water level was maintained at the nipple level. No 
desaturation or respiratory complications were noted among these patients. 
Conclusion: This study demonstrates the safety and feasibility of aquatic 
therapy for adult patients with spinal cord injuries and pressure ulcers, 
colostomy or ileostomy bags, supra pubic catheters, indwelling catheters, 
and tracheostomy tube. Aquatic therapy is a valuable therapeutic tool for 
patients with SCI with various complex comorbidities.
EMTREE DRUG INDEX TERMS
  water; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  female; male; safety; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  accident; adult; classification; colostomy bag; comorbidity; complication; decubitus; dry skin; feasibility study; human; ileostomy bag; indwelling catheter; lower limb; major clinical study; medical record review; nipple; suprapubic catheter; tracheostomy tube; walking; wound; young adult; 
CAS REGISTRY NUMBERS
  water (7732-18-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617785195
DOI
  10.1080/10790268.2016.1207960
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2016.1207960
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1080%2F10790268.2016.1207960&atitle=Safety+of+aquatic+therapy+for+adults+with+complex+medical+conditions+among+chronic+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=39&issue=5&spage=568&epage=569&aulast=Recio&aufirst=Albert+C.&auinit=A.C.&aufull=Recio+A.C.&coden=&isbn=&pages=568-569&date=2016&auinit1=A&auinitm=C
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 294
TITLE
  Subclassification of GMFCS level-5 cerebral palsy as a predictor of 
complications and health-related quality of life after spinal arthrodesis
AUTHOR NAMES
  Jain A.; Sponseller P.D.; Shah S.A.; Samdani A.; Cahill P.J.; Yaszay B.; Njoku D.B.; Abel M.F.; Newton P.O.; Marks M.C.; Narayanan U.G.
AUTHOR ADDRESSES
  (Jain A.; Sponseller P.D., psponse@jhmi.edu) Department of Orthopaedic 
Surgery, Johns Hopkins University, Baltimore, United States.
(Njoku D.B.) Department of Anesthesiology, Johns Hopkins University, 
Baltimore, United States.
(Shah S.A.) Nemours/Alfred I. DuPont Hospital for Children, Wilmington, 
United States.
(Samdani A.; Cahill P.J.) Department of Orthopaedic Surgery, Shriners 
Hospitals for Children, Philadelphia, United States.
(Yaszay B.; Newton P.O.) Department of Orthopedics, Rady Children's Hospital 
of San Diego, San Diego, United States.
(Abel M.F.) Department of Orthopaedic Surgery, University of Virginia, 
Charlottesville, United States.
(Marks M.C.) Setting Scoliosis Straight Foundation, San Diego, United 
States.
(Narayanan U.G.) Division of Orthopaedic Surgery, Hospital for Sick 
Children, University of Toronto, Toronto, Canada.
AiP/IP ENTRY DATE
  2017-02-06
FULL RECORD ENTRY DATE
  2017-02-14
SOURCE
  Journal of Bone and Joint Surgery - American Volume (2016) 98:21 
(1821-1828). Date of Publication: 2016
VOLUME
  98
ISSUE
  21
FIRST PAGE
  1821
LAST PAGE
  1828
DATE OF PUBLICATION
  2016
ISSN
  1535-1386 (electronic)
  0021-9355
BOOK PUBLISHER
  Lippincott Williams and Wilkins, agents@lww.com
ABSTRACT
  Background: The Gross Motor Function Classification System (GMFCS) of 
cerebral palsy categorizes patients by mobility. Patients at GMFCS level 5 
are considered the most disabled and at high risk of hip and spine problems, 
yet they represent a wide spectrum of function. Our aim was to subclassify 
patients at GMFCS level 5 who underwent spinal arthrodesis on the basis of 
central neuromotor impairments and to assess whether subclassification 
predicted postoperative complications and changes in health-related quality 
of life. Methods: Using a prospective cerebral palsy registry, we identified 
199 patients at GMFCS level 5 who underwent spinal arthrodesis from 2008 to 
2013. Patients were assigned to subgroups according to preoperative central 
neuromotor impairments: the presence of a gastrostomy tube, a tracheostomy, 
history of seizures, and nonverbal status. Nine percent of patients had 0 
impairments (GMFCS level 5.0), 14% had 1 impairment (level 5.1), 26% had 2 
impairments (level 5.2), and 51% had 3 or 4 impairments (level 5.3). The 
Caregiver Priorities and Child Health Index of Life with Disabilities 
(CPCHILD) questionnaire was used for preoperative and postoperative 
health-related quality-of-life outcome assessments, and major complications 
were recorded. Results: The rate of major complications increased 
significantly with higher GMFCS level-5 subtype (p = 0.002), with 12% at 
level 5.0, 21% at level 5.1, 31% at level 5.2, and 49% at level 5.3. Five of 
the 7 patients who died within the follow-upperiod were at level 5.3. No 
significant differences were found among subgroups with respect to the 
magnitude of correction of the major coronal curve or pelvic obliquity. 
Preoperative and final follo w-up CPCHILD total scores decreased 
significantly from GMFCS level 5.0 to level 5.3. However, no significant 
differences were found by subgroup with respect to the magnitude of 
improvement in CPCHILD total scores from the preoperative to t he final 
follow-up evaluation (p = 0.597). Conclusions: Stratification based on 
central neuromotor impairments can help to identify patients with cerebral 
palsy at GMFCS level 5 who are at higher risk for developing complications 
after spinal arthrodesis. Level of Evidence: Prognostic Level III. See 
Instructions for Authors for a complete description of levels of evidence
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arthrodesis; cerebral palsy (disease management); Gross Motor Function Classification System; postoperative complication (complication); quality of life; spine; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; Caregiver Priorities and Child Health Index of Life with Disabilities 
questionna; deep vein thrombosis (complication); emotion; female; follow up; health; human; interpersonal communication; lung embolism (complication); major clinical study; male; mental deficiency; motor neuron disease; operative blood loss (complication); outcome assessment; postoperative care; postoperative infection (complication); preoperative evaluation; priority journal; prospective study; questionnaire; seizure; social interaction; stomach tube; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170085282
MEDLINE PMID
  27807115 (http://www.ncbi.nlm.nih.gov/pubmed/27807115)
PUI
  L614256545
DOI
  10.2106/JBJS.15.01359
FULL TEXT LINK
  http://dx.doi.org/10.2106/JBJS.15.01359
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15351386&id=doi:10.2106%2FJBJS.15.01359&atitle=Subclassification+of+GMFCS+level-5+cerebral+palsy+as+a+predictor+of+complications+and+health-related+quality+of+life+after+spinal+arthrodesis&stitle=J.+Bone+Jt.+Surg.+Am.+Vol.&title=Journal+of+Bone+and+Joint+Surgery+-+American+Volume&volume=98&issue=21&spage=1821&epage=1828&aulast=Jain&aufirst=Amit&auinit=A.&aufull=Jain+A.&coden=JBJSA&isbn=&pages=1821-1828&date=2016&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 295
TITLE
  Relationship Between Depressive State and Treatment Characteristics of Acute 
Cervical Spinal Cord Injury in Japan
AUTHOR NAMES
  Matsuda Y.; Kubo T.; Fujino Y.; Matsuda S.; Wada F.; Sugita A.
AUTHOR ADDRESSES
  (Matsuda Y.) Department of Preventive Medicine and Community Health, School 
of Medicine, University of Occupational and Environmental Health
(Kubo T.; Fujino Y.; Matsuda S.; Wada F.; Sugita A.)
FULL RECORD ENTRY DATE
  2017-05-10
SOURCE
  Journal of epidemiology (2016) 26:1 (30-35). Date of Publication: 2016
VOLUME
  26
ISSUE
  1
FIRST PAGE
  30
LAST PAGE
  35
DATE OF PUBLICATION
  2016
ISSN
  1349-9092 (electronic)
ABSTRACT
  BACKGROUND: Few studies have assessed whether treatment of acute cervical 
spinal cord injury (SCI) patients contributes to depression.METHODS: Using 
an administrative database, we assessed patients for whom the diagnosis was 
unspecified injuries of cervical spinal cord (International Classification 
of Diseases and Injuries-10th (ICD-10) code; S14.1). We categorized patients 
with codes for depressive episode (ICD-10 code; F32) or recurrent depressive 
disorder (F33), or those prescribed antidepressants (tricyclic, tetracyclic, 
Selective Serotonin Reuptake Inhibitors, Serotonin Noradrenaline Reuptake 
Inhibitors, Trazodone, Sulpiride, or Mirtazapine) as having a depressive 
state. We compared the rate of each acute treatment between the depressive 
state group and the non-depressive state group using chi-square tests, and a 
multiple logistic regression model was used to identify the association 
between the acute treatment and depressive state.RESULTS: There were 151 
patients who were judged to be in a depressive state, and the other 2115 
patients were categorized into the non-depressive state group. Intervention 
of intravenous anesthesia, tracheostomy, artificial respiration, and 
gastrostomy had a significant positive correlation with depressive state. 
Multiple logistic regression analysis showed that tracheostomy (odds ratio 
[OR] 2.18; 95% confidence interval [CI], 1.09-4.38) and artificial 
respiration (OR 2.28; 95% CI, 1.32-3.93) were significantly associated with 
depressive state, and men had a 36% reduction in the risk of depressive 
state compared with women (OR 0.64; 95% CI, 0.44-0.94), whereas age, 
wound-treatment, all of the orthopedic procedures, intravenous anesthesia, 
and gastrostomy were not associated with depressive state.CONCLUSIONS: These 
findings suggest that tracheostomy, artificial respiration and female gender 
in the acute phase after cervical SCI might be associated with the 
development of depression.
EMTREE MEDICAL INDEX TERMS
  acute disease; adolescent; adult; child; depression (epidemiology); factual database; female; human; infant; Japan; male; middle aged; newborn; preschool child; psychology; risk factor; spinal cord injury (therapy); young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  26567604 (http://www.ncbi.nlm.nih.gov/pubmed/26567604)
PUI
  L615898184
DOI
  10.2188/jea.JE20140233
FULL TEXT LINK
  http://dx.doi.org/10.2188/jea.JE20140233
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13499092&id=doi:10.2188%2Fjea.JE20140233&atitle=Relationship+Between+Depressive+State+and+Treatment+Characteristics+of+Acute+Cervical+Spinal+Cord+Injury+in+Japan&stitle=J+Epidemiol&title=Journal+of+epidemiology&volume=26&issue=1&spage=30&epage=35&aulast=Matsuda&aufirst=Yasufumi&auinit=Y.&aufull=Matsuda+Y.&coden=&isbn=&pages=30-35&date=2016&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2017 Medline is the source for the citation and abstract of this 
record.

RECORD 296
TITLE
  Respiratory problems and management in people with spinal cord injury
AUTHOR NAMES
  Berlowitz D.J.; Wadsworth B.; Ross J.
AUTHOR ADDRESSES
  (Berlowitz D.J., david.berlowitz@austin.org.au) Institute for Breathing and 
Sleep, Austin Health, Heidelberg, Australia.
(Berlowitz D.J., david.berlowitz@austin.org.au) University of Melbourne, 
Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Australia.
(Wadsworth B.) School of Human Services and Social Work, Griffith 
University, Logan Campus, Australia.
(Wadsworth B.) Physiotherapy Department, Princess Alexandra Hospital, 
Woolloongabba, Australia.
(Ross J.) Victorian Spinal Cord Service, Austin Health, Heidelberg, 
Australia.
AiP/IP ENTRY DATE
  2017-01-24
FULL RECORD ENTRY DATE
  2017-02-07
SOURCE
  Breathe (2016) 12:4 (328-340). Date of Publication: 2016
VOLUME
  12
ISSUE
  4
FIRST PAGE
  328
LAST PAGE
  340
DATE OF PUBLICATION
  2016
ISSN
  2073-4735 (electronic)
  1810-6838
BOOK PUBLISHER
  European Respiratory Society, info@ersnet.org
ABSTRACT
  Spinal cord injury (SCI) is characterised by profound respiratory compromise 
secondary to the level of loss of motor, sensory and autonomic control 
associated with the injury. This review aims to detail these anatomical and 
physiological changes after SCI, and outline their impact on respiratory 
function. Injury-related impairments in strength substantially alter 
pulmonary mechanics, which in turn affect respiratory management and care. 
Options for treatments must therefore be considered in light of these 
limitations.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory tract disease (surgery); spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  article; autonomic dysfunction; body position; breathing; cardiovascular disease; chest infection; comorbidity; coughing; diaphragm; electrotherapy; extubation; health status; hospital readmission; human; life satisfaction; long term care; lung edema; lung embolism; lung mechanics; lung volume; magnetic stimulation; motor performance; muscle training; positive end expiratory pressure; quality of life; respiratory tract disease assessment; sleep disordered breathing (therapy); speech; tracheostomy; ventilator weaning; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170056800
PUI
  L614127043
DOI
  10.1183/20734735.012616
FULL TEXT LINK
  http://dx.doi.org/10.1183/20734735.012616
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20734735&id=doi:10.1183%2F20734735.012616&atitle=Respiratory+problems+and+management+in+people+with+spinal+cord+injury&stitle=Breathe&title=Breathe&volume=12&issue=4&spage=328&epage=340&aulast=Berlowitz&aufirst=David+J.&auinit=D.J.&aufull=Berlowitz+D.J.&coden=&isbn=&pages=328-340&date=2016&auinit1=D&auinitm=J
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 297
TITLE
  Functional and radiological outcome in patients undergoing three level 
corpectomy for multi-level cervical spondylotic myelopathy and ossified 
posterior longitudinal ligament
AUTHOR NAMES
  Gupta A.; Rajshekhar V.
AUTHOR ADDRESSES
  (Gupta A.; Rajshekhar V., rajshekhar@cmcvellore.ac.in) Department of 
Neurological Sciences, Christian Medical College Hospital, Vellore, Tamil 
Nadu, India.
CORRESPONDENCE ADDRESS
  V. Rajshekhar, Department of Neurological Sciences, Christian Medical 
College Hospital, Vellore, Tamil Nadu, India. Email: 
rajshekhar@cmcvellore.ac.in
AiP/IP ENTRY DATE
  2016-02-01
FULL RECORD ENTRY DATE
  2018-10-19
SOURCE
  Neurology India (2016) 64:1 (90-96). Date of Publication: 1 Jan 2016
VOLUME
  64
ISSUE
  1
FIRST PAGE
  90
LAST PAGE
  96
DATE OF PUBLICATION
  1 Jan 2016
ISSN
  1998-4022 (electronic)
  0028-3886
BOOK PUBLISHER
  Wolters Kluwer Medknow Publications, B9, Kanara Business Centre, off Link 
Road, Ghatkopar (E), Mumbai, India.
ABSTRACT
  Background: To review our experience with patients undergoing 3 level 
cervical central corpectomy (CC) with un-instrumented fibular autograft 
fusion. Materials and Methods: This is a retrospective study, involving 33 
patients with cervical spondylotic myelopathy (CSM) or ossified posterior 
longitudinal ligament (OPLL) who underwent a 3 level CC between 2002 and 
2010. The patients were followed up clinically and radiologically. Their 
functional status was assessed using Nurick's grading system. Parameters 
such as intraoperative complications, segmental curvature of the cervical 
spine, graft subsidence, graft fusion and functional outcome of these 
patients were assessed. Results: There was transient morbidity in 28.6% of 
patients, with no permanent morbidity or mortality. We obtained follow up in 
29 patients (87.9%) with a mean duration of follow up of 65.1 months (range, 
12 to 138 months). The mean difference of segmental cervical curvature on 
follow up was 3.60(0) and the average graft subsidence was 5.70 mm. We 
achieved a fusion rate of 90%. There was no instance of graft extrusion in 
our series. There was a significant improvement in the functional status of 
our patients (from Nurick grade 3.55 to 2.42; P = 0.0001), with no clinical 
deterioration in any patient. Conclusions: Three level cervical corpectomy 
with un-instrumented fusion is a relatively safe surgery in experienced 
hands, and can achieve excellent clinical and radiological outcomes.
EMTREE DRUG INDEX TERMS
  steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical corpectomy; cervical spondylotic myelopathy (surgery); ligament calcinosis (surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cervical spine radiography; clinical article; decompression surgery; dysphagia; female; follow up; functional status assessment; human; liquorrhea (complication); male; morbidity; Nurick grading system; peroperative complication (complication); pneumonia (complication); postoperative period; respiratory arrest (complication, surgery); retrospective study; spine disease (complication); spine fusion; steroid therapy; surgical mortality; surgical technique; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160070196
MEDLINE PMID
  26754998 (http://www.ncbi.nlm.nih.gov/pubmed/26754998)
PUI
  L607919409
DOI
  10.4103/0028-3886.173654
FULL TEXT LINK
  http://dx.doi.org/10.4103/0028-3886.173654
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19984022&id=doi:10.4103%2F0028-3886.173654&atitle=Functional+and+radiological+outcome+in+patients+undergoing+three+level+corpectomy+for+multi-level+cervical+spondylotic+myelopathy+and+ossified+posterior+longitudinal+ligament&stitle=Neurol.+India&title=Neurology+India&volume=64&issue=1&spage=90&epage=96&aulast=Gupta&aufirst=Ankush&auinit=A.&aufull=Gupta+A.&coden=NURYA&isbn=&pages=90-96&date=2016&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 298
TITLE
  Delayed post trauma retropharyngeal hematoma with acute airway obstruction 
in a non cervical-spine injury
AUTHOR NAMES
  Vengathajalam S.; Rahim F.A.; Zakaria Z.
AUTHOR ADDRESSES
  (Vengathajalam S., malar_veng@yahoo.com; Rahim F.A.; Zakaria Z.) Department 
of Otorhinolaryngology, Penang General Hospital, Malaysia.
CORRESPONDENCE ADDRESS
  S. Vengathajalam, Department of Otorhinolaryngology, Penang General 
Hospital, Malaysia. Email: malar_veng@yahoo.com
AiP/IP ENTRY DATE
  2016-05-27
FULL RECORD ENTRY DATE
  2016-12-20
SOURCE
  Rawal Medical Journal (2016) 41:2 (253-255). Date of Publication: 2016
VOLUME
  41
ISSUE
  2
FIRST PAGE
  253
LAST PAGE
  255
DATE OF PUBLICATION
  2016
ISSN
  0303-5212
BOOK PUBLISHER
  Pakistan Medical Association
ABSTRACT
  We report a case of a 10 year old boy who presented with delayed onset of 
retropharyngeal hematoma post trauma with acute airway obstruction. He had 
motor vehicle accident 2 weeks prior and sustained extensive subcutaneous 
emphysema with bilateral pneumothorax due to rib fractures. CT showed 
hypodense collection measuring 1cm x 1cm x 2cm at retropharyngeal space with 
compression at the posterior wall of the trachea. He was intubated and 
underwent tracheostomy for persistent upper airway obstruction.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction; hematoma (diagnosis); retropharyngeal hematoma (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  article; breathing disorder; bronchoscopy; case report; child; computer assisted tomography; emphysema; endotracheal intubation; follow up; human; laryngoscopy; male; school child; tracheostomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Hematology (25)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160378232
PUI
  L610394271
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03035212&id=doi:&atitle=Delayed+post+trauma+retropharyngeal+hematoma+with+acute+airway+obstruction+in+a+non+cervical-spine+injury&stitle=Rawal+Med.+J.&title=Rawal+Medical+Journal&volume=41&issue=2&spage=253&epage=255&aulast=Vengathajalam&aufirst=Selvamalar&auinit=S.&aufull=Vengathajalam+S.&coden=&isbn=&pages=253-255&date=2016&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 299
TITLE
  A Novel Combined Hybrid Approach to Enable Revascularisation of a 
Trauma-Induced Subclavian Artery Injury
AUTHOR NAMES
  Sabbagh C.N.; Chowdhury M.M.; Durrani A.; Van Rensburg L.; Koo B.; Coughlin P.A.
AUTHOR ADDRESSES
  (Sabbagh C.N., cezar.sabbagh@doctors.net.uk; Chowdhury M.M.; Coughlin P.A.) 
Division of Vascular and Endovascular Surgery, Addenbrooke's Hospital, 
Cambridge University Hospital Trust, Cambridge, United Kingdom.
(Durrani A.) Division of Plastic Surgery, University of Cambridge, 
Addenbrooke's Hospital, Cambridge, United Kingdom.
(Van Rensburg L.) Division of Orthopaedic Surgery, University of Cambridge, 
Addenbrooke's Hospital, Cambridge, United Kingdom.
(Koo B.) Division of Interventional Radiology, University of Cambridge, 
Addenbrooke's Hospital, Cambridge, United Kingdom.
CORRESPONDENCE ADDRESS
  C.N. Sabbagh, Division of Vascular and Endovascular Surgery, Addenbrooke's 
Hospital, Cambridge University Hospital Trust, Cambridge, United Kingdom. 
Email: cezar.sabbagh@doctors.net.uk
AiP/IP ENTRY DATE
  2016-06-20
FULL RECORD ENTRY DATE
  2016-06-29
SOURCE
  EJVES Short Reports (2016) 32 (18-20). Date of Publication: 2016
VOLUME
  32
FIRST PAGE
  18
LAST PAGE
  20
DATE OF PUBLICATION
  2016
ISSN
  2405-6553 (electronic)
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  Introduction This case highlights the complexity of upper limb 
revascularization after a subclavian artery traumatic injury and strengthens 
the role of a hybrid/multi-disciplinary approach to such injuries. Report A 
45-year-old male patient presented with an acute right upper limb following 
a traumatic injury to the right subclavian artery due to a motor vehicle 
accident (MVA). Associated injuries included an unstable cervical spine 
injury, a large open right clavicular injury, and a brain injury, which 
limited the potential revascularisation options available. The arm was 
revascularised using a hybrid endovascular/open surgical approach, namely 
embolization of the proximal subclavian artery (just distal to vertebral 
artery) and a right common femoral artery to distal axillary artery bypass 
using prosthetic material. Discussion Blunt injuries to the subclavian 
artery are often high impact, complex and associated with multiple injuries 
to surrounding structures, which limit the role of standard procedures used 
in the elective setting. This case highlights the role of multidisciplinary 
team involvement, using a hybrid approach and a novel distal inflow site to 
restore upper limb perfusion.
EMTREE DRUG INDEX TERMS
  collagen sponge; gentamicin; hemostatic agent; heparin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artery bypass; artery injury; artificial embolization; coronary artery bypass surgery; endovascular surgery; leg revascularization; right subclavian artery; subclavian artery traumatic injury; 
EMTREE MEDICAL INDEX TERMS
  abdominal wall; adult; Amplatzer vascular plug; aortic arch; artery catheter; article; atelectasis; axillary artery; brachial plexus injury; brachiocephalic trunk; brain contusion; brain injury; breathing; case report; cervical collar; cervical spine fracture; cervical spine injury; chest tube; clavicle; clavicle fracture; clavicular injury; cold; computer assisted tomography; convulsion; cranial nerve paralysis; disease association; electric activity; fasciotomy; femoral artery; fibula fracture; general anesthesia; hematoma; hospital admission; hospital readmission; human; Human alphaherpesvirus 1; intensive care unit; laceration; limb injury; liver injury; male; mediastinum disease; medical history; middle aged; neurorehabilitation; oculomotor nerve disease; paresis; physiotherapy; pneumonia; politef implant; priority journal; respiratory tract intubation; resuscitation; rhabdomyolysis; scapula fracture; shoulder injury; sixth cervical vertebra; skin incision; speech production aid; speech therapy; sternum; subarachnoid hemorrhage; subclavian artery; surgical technique; tension pneumothorax; thorax drainage; tibia fracture; tracheostomy; traffic accident; vertebral artery; wound; 
DEVICE TRADE NAMES
  Amplatzer  , United StatesSt Jude

  ePTFE graft  Maquet

DEVICE MANUFACTURERS
  Maquet
   (United States)St Jude
CAS REGISTRY NUMBERS
  gentamicin (1392-48-9, 1403-66-3, 1405-41-0)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160446255
PUI
  L610662223
DOI
  10.1016/j.ejvssr.2016.03.006
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ejvssr.2016.03.006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=24056553&id=doi:10.1016%2Fj.ejvssr.2016.03.006&atitle=A+Novel+Combined+Hybrid+Approach+to+Enable+Revascularisation+of+a+Trauma-Induced+Subclavian+Artery+Injury&stitle=EJVES+Short+Rep.&title=EJVES+Short+Reports&volume=32&issue=&spage=18&epage=20&aulast=Sabbagh&aufirst=C.N.&auinit=C.N.&aufull=Sabbagh+C.N.&coden=&isbn=&pages=18-20&date=2016&auinit1=C&auinitm=N
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 300
TITLE
  Bradycardia Associated with Steroid Use for Laryngeal Edema in an Adult: A 
Case Report and Literature Review
AUTHOR NAMES
  John P.R.; Khaladj-Ghom A.; Still K.L.
AUTHOR ADDRESSES
  (John P.R., preeti.john@va.gov) Baltimore VA Medical Center, Baltimore, 
United States.
(John P.R., preeti.john@va.gov) Department of Surgery, University of 
Maryland Medical Center, Baltimore, United States.
(John P.R., preeti.john@va.gov; Still K.L., kimberly.still2@va.gov) 
Baltimore VA Medical Center, Surgical Intensive Care Unit, 10 North Greene 
Street, 5C-119, Baltimore, United States.
(Khaladj-Ghom A., akhaladjghom@smail.umaryland.edu) University of Maryland 
Medical Center, 16 S. Eutaw, Baltimore, United States.
CORRESPONDENCE ADDRESS
  P.R. John, Baltimore VA Medical Center, Baltimore, United States. Email: 
preeti.john@va.gov
AiP/IP ENTRY DATE
  2016-12-21
FULL RECORD ENTRY DATE
  2016-12-26
SOURCE
  Case Reports in Cardiology (2016) 2016 Article Number: 9785467. Date of 
Publication: 2016
VOLUME
  2016
DATE OF PUBLICATION
  2016
ISSN
  2090-6412 (electronic)
  2090-6404
BOOK PUBLISHER
  Hindawi Publishing Corporation, 410 Park Avenue, 15th Floor, 287 pmb, New 
York, United States.
ABSTRACT
  Steroids are used for specific indications in the perioperative period to 
reduce laryngeal or spinal cord edema, or for prophylaxis and treatment of 
postoperative nausea and vomiting. Given the other potential causes for 
hemodynamic alterations in the perioperative setting, it is important for 
physicians to be aware of cardiovascular side effects of short term 
steroids. Changes in blood pressure and heart rate, cardiac dysrhythmias, 
and even death have been described in patients receiving short term 
intravenous steroids. Bradycardia has been reported following short term 
methylprednisolone and dexamethasone therapy in both adult and pediatric 
patients. There are only two case reports in the literature of bradycardia 
following short term intravenous dexamethasone use in adult patients. This 
is the first case report that describes bradycardia following the use of 
dexamethasone in the postoperative setting for management of laryngeal edema 
in an adult. Telemetry and twelve lead electrocardiograms revealed sinus 
bradycardia and correlated directly with administration of dexamethasone in 
our patient. Bradycardia resolved following discontinuation of 
dexamethasone. We advocate for hemodynamic monitoring in patients receiving 
more than one dose of intravenous steroid therapy in the perioperative 
period, especially those with known cardiac and hepatic comorbidities and 
those taking medications with negative chronotropic effects.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  dexamethasone (adverse drug reaction, drug therapy, intravenous drug 
administration); 
EMTREE DRUG INDEX TERMS
  midazolam; nafcillin (drug therapy); propofol; troponin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  larynx edema (drug therapy, drug therapy); sinus bradycardia (side effect, side effect); 
EMTREE MEDICAL INDEX TERMS
  adult; antibiotic therapy; case report; corticosteroid therapy; device infection (complication); disease association; drug withdrawal; electrocardiography; endotracheal intubation; general anesthesia; human; hypercapnia; laryngoscopy; male; middle aged; nonhuman; noninvasive ventilation; respiratory failure; review; small intestine resection; sputum culture; Staphylococcus infection (diagnosis, drug therapy); stridor; surgical infection (complication); surgical mesh (adverse device effect); telemetry; tracheostomy; videolaryngoscope; work of breathing; 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
  midazolam (59467-70-8)
  nafcillin (147-52-4, 985-16-0)
  propofol (2078-54-8)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160918986
PUI
  L613626651
DOI
  10.1155/2016/9785467
FULL TEXT LINK
  http://dx.doi.org/10.1155/2016/9785467
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20906412&id=doi:10.1155%2F2016%2F9785467&atitle=Bradycardia+Associated+with+Steroid+Use+for+Laryngeal+Edema+in+an+Adult%3A+A+Case+Report+and+Literature+Review&stitle=Case+Rep.+Cardiol.&title=Case+Reports+in+Cardiology&volume=2016&issue=&spage=&epage=&aulast=John&aufirst=Preeti+R.&auinit=P.R.&aufull=John+P.R.&coden=&isbn=&pages=-&date=2016&auinit1=P&auinitm=R
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 301
TITLE
  To the editor
AUTHOR NAMES
  Zou M.-X.; Lv G.-H.; Wang X.-B.; Li J.
AUTHOR ADDRESSES
  (Zou M.-X.; Lv G.-H.; Wang X.-B.; Li J., jingli1969@126.com) Department of 
Spine Surgery, Second Xiangya Hospital, Central South University, Changsha, 
China.
AiP/IP ENTRY DATE
  2016-12-21
FULL RECORD ENTRY DATE
  2017-02-27
SOURCE
  Spine (2016) 41:23 (E1429-E1432). Date of Publication: 2016
VOLUME
  41
ISSUE
  23
FIRST PAGE
  E1429
LAST PAGE
  E1432
DATE OF PUBLICATION
  2016
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  hematoma; human; letter; nuclear magnetic resonance imaging; priority journal; risk factor; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160920122
PUI
  L613736283
DOI
  10.1097/BRS.0000000000001904
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000001904
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000001904&atitle=To+the+editor&stitle=Spine&title=Spine&volume=41&issue=23&spage=E1429&epage=E1432&aulast=Zou&aufirst=Ming-Xiang&auinit=M.-X.&aufull=Zou+M.-X.&coden=SPIND&isbn=&pages=E1429-E1432&date=2016&auinit1=M&auinitm=-X
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 302
TITLE
  Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor 
Neuron Disease and Frontotemporal Dementia
AUTHOR NAMES
  Takeuchi R.; Toyoshima Y.; Tada M.; Tanaka H.; Shimizu H.; Shiga A.; Miura T.; Aoki K.; Aikawa A.; Ishizawa S.; Ikeuchi T.; Nishizawa M.; Kakita A.; Takahashi H.
AUTHOR ADDRESSES
  (Takeuchi R.; Toyoshima Y., yasuko@bri.niigata-u.ac.jp; Tada M.; Tanaka H.; 
Shimizu H.; Kakita A.; Takahashi H.) Department of Pathology, Brain Research 
Institute, University of Niigata, 1-757 Asahimachi, Chuo-ku, Niigata, Japan.
(Takeuchi R.; Nishizawa M.) Department of Neurology, Brain Research 
Institute, University of Niigata, Niigata, Japan.
(Shiga A.) Department of Molecular Neuroscience, Brain Research Institute, 
University of Niigata, Niigata, Japan.
(Miura T.; Aoki K.) Department of Molecular Genetics, Brain Research 
Institute, University of Niigata, Niigata, Japan.
(Ikeuchi T.) Department of Neurology, Toyama Prefectural Central Hospital, 
Toyama, Japan.
(Aikawa A.; Ishizawa S.) Department of Pathology, Toyama Prefectural Central 
Hospital, Toyama, Japan.
CORRESPONDENCE ADDRESS
  Y. Toyoshima, Department of Pathology, Brain Research Institute, University 
of Niigata, 1-757 Asahimachi, Chuo-ku, Niigata, Japan. Email: 
yasuko@bri.niigata-u.ac.jp
AiP/IP ENTRY DATE
  2015-06-05
FULL RECORD ENTRY DATE
  2016-02-11
SOURCE
  Brain Pathology (2016) 26:1 (82-94). Date of Publication: 1 Jan 2016
VOLUME
  26
ISSUE
  1
FIRST PAGE
  82
LAST PAGE
  94
DATE OF PUBLICATION
  1 Jan 2016
ISSN
  1750-3639 (electronic)
  1015-6305
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
ABSTRACT
  Amyotrophic lateral sclerosis (ALS) may be accompanied by frontotemporal 
dementia (FTD). We report a case of glial mixed tau and TDP-43 
proteinopathies in a Japanese patient diagnosed clinically as having ALS-D. 
Autopsy revealed loss of lower motor neurons and degeneration of the 
pyramidal tracts in the spinal cord and brain stem. The brain showed 
frontotemporal lobar degeneration (FTLD), the most severe neuronal loss and 
gliosis being evident in the precentral gyrus. Although less severe, such 
changes were also observed in other brain regions, including the basal 
ganglia and substantia nigra. AT8 immunostaining revealed that predominant 
occurrence of astrocytic tau lesions termed globular astrocytic inclusions 
(GAIs) was a feature of the affected regions. These GAIs were Gallyas-Braak 
negative. Neuronal and oligodendrocytic tau lesions were comparatively 
scarce. pS409/410 immunostaining also revealed similar neuronal and glial 
TDP-43 lesions. Interestingly, occasional co-localization of tau and TDP-43 
was evident in the GAIs. Immunoblot analyses revealed band patterns 
characteristic of a 4-repeat (4R) tauopathy, corticobasal degeneration and a 
TDP-43 proteinopathy, ALS/FTLD-TDP-Type-B. No mutations were found in the 
MAPT or TDP-43 genes. We consider that this patient harbored a distinct, 
sporadic globular glial mixed 4R tau and TDP-43 proteinopathy associated 
with motor neuron disease and FTD.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  TAR DNA binding protein (endogenous compound); tau protein (endogenous compound); 
EMTREE DRUG INDEX TERMS
  amyloid beta protein (endogenous compound); glial fibrillary acidic protein (endogenous compound); Sarkosyl insoluble tau (endogenous compound); sequestosome 1 (endogenous compound); ubiquitin (endogenous compound); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  frontotemporal dementia; motor neuron disease; tauopathy; TDP 43 proteinopathy; 
EMTREE MEDICAL INDEX TERMS
  acute cholecystitis; aged; amygdala; article; assisted ventilation; brain atrophy; brain stem; capsula interna; case report; cause of death; cell inclusion; cerebellum cortex; cerebral peduncle; coiled body; dentate gyrus; dentate nucleus; facial nerve nucleus; female; gene mutation; globus pallidus; human; human tissue; hypoglossal nucleus; immunoblotting; immunofluorescence; immunohistochemistry; inferior olivary nucleus; locus ceruleus; Meynert basal nucleus; motoneuron; motor cortex; neuropil thread; oculomotor nucleus; pontine nucleus; putamen; pyramidal tract; red nucleus; respiratory distress (surgery); senile plaque; spinal cord dorsal horn; spinal cord ventral horn; substantia nigra; subthalamic nucleus; tectum; thalamus; tracheotomy; trigeminal motor nucleus; very elderly; white matter; 
CAS REGISTRY NUMBERS
  amyloid beta protein (109770-29-8)
  ubiquitin (60267-61-0)
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015086067
MEDLINE PMID
  25787090 (http://www.ncbi.nlm.nih.gov/pubmed/25787090)
PUI
  L604640533
DOI
  10.1111/bpa.12262
FULL TEXT LINK
  http://dx.doi.org/10.1111/bpa.12262
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17503639&id=doi:10.1111%2Fbpa.12262&atitle=Globular+Glial+Mixed+Four+Repeat+Tau+and+TDP-43+Proteinopathy+with+Motor+Neuron+Disease+and+Frontotemporal+Dementia&stitle=Brain+Pathol.&title=Brain+Pathology&volume=26&issue=1&spage=82&epage=94&aulast=Takeuchi&aufirst=Ryoko&auinit=R.&aufull=Takeuchi+R.&coden=BRPAE&isbn=&pages=82-94&date=2016&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 303
TITLE
  Acute flaccid paralysis following spinal anaesthesia: A diagnostic dilemma
AUTHOR NAMES
  Dassanayake A.
AUTHOR ADDRESSES
  (Dassanayake A., asithadassanayake@yahoo.com) National Hospital of Sri 
Lanka, Sri Lanka.
CORRESPONDENCE ADDRESS
  A.F.S. Dassanayake, National Hospital of Sri Lanka, Sri Lanka. Email: 
asithadassanayake@yahoo.com
AiP/IP ENTRY DATE
  2016-02-19
FULL RECORD ENTRY DATE
  2016-02-24
SOURCE
  Sri Lankan Journal of Anaesthesiology (2016) 24:1 (46-48). Date of 
Publication: 2016
VOLUME
  24
ISSUE
  1
FIRST PAGE
  46
LAST PAGE
  48
DATE OF PUBLICATION
  2016
ISSN
  1391-8834
BOOK PUBLISHER
  College of Anaesthesiologists of Sri Lanka, 44/5A, Gnanartha 
Pradeepaya,Mawatha,, Colombo, Sri Lanka.
ABSTRACT
  We report on a patient who developed an acute flaccid paralysis following 
spinal anaesthesia for a right sided inguinal hernia repair and orchidopexy, 
while on post exposure prophylaxis with anti-rabies vaccination following a 
dog bite.
EMTREE DRUG INDEX TERMS
  aciclovir (intravenous drug administration); cefuroxime (intravenous drug administration); rabies vaccine (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  flaccid paralysis; rabies (drug therapy, complication, diagnosis, drug therapy, prevention); spinal anesthesia; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; autopsy; blood analysis; bulbar paralysis (complication); case report; death; diaphragm paralysis (complication); dog bite; Glasgow coma scale; hernioplasty; hospital admission; human; inguinal hernia (surgery); intensive care unit; lumbar puncture; male; middle aged; muscle weakness; nerve conduction; neurologic examination; orchidopexy; paresthesia; post exposure prophylaxis; postoperative period; restlessness; tracheostomy; 
CAS REGISTRY NUMBERS
  aciclovir (59277-89-3)
  cefuroxime (55268-75-2, 56238-63-2)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160128277
PUI
  L608335127
DOI
  10.4038/slja.v24i1.8118
FULL TEXT LINK
  http://dx.doi.org/10.4038/slja.v24i1.8118
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13918834&id=doi:10.4038%2Fslja.v24i1.8118&atitle=Acute+flaccid+paralysis+following+spinal+anaesthesia%3A+A+diagnostic+dilemma&stitle=Sri+Lankan+J.+Anaesthesiol.&title=Sri+Lankan+Journal+of+Anaesthesiology&volume=24&issue=1&spage=46&epage=48&aulast=Dassanayake&aufirst=Asitha&auinit=A.&aufull=Dassanayake+A.&coden=&isbn=&pages=46-48&date=2016&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 304
TITLE
  Globular glial mixed four repeat tau and TDP-43 proteinopathy with motor 
neuron disease and frontotemporal dementia
AUTHOR NAMES
  Takeuchi R.; Toyoshima Y.; Tada M.; Shiga A.; Miura T.; Aoki K.; Ikeuchi T.; Nishizawa M.; Kakita A.; Takahashi H.
AUTHOR ADDRESSES
  (Takeuchi R., ryokot5695@wish.ocn.ne.jp; Toyoshima Y.; Tada M.; Kakita A.; 
Takahashi H.) Department of Pathology, Niigata, Japan.
(Shiga A.) Department of Molecular Neuroscience, Brain Research Institute, 
University of Niigata, Niigata, Japan.
(Miura T.; Aoki K.) Department of Neurology, Toyama Prefectural Central 
Hospital, Toyama, Japan.
(Ikeuchi T.) Department of Molecular Genetics, Niigata, Japan.
(Takeuchi R., ryokot5695@wish.ocn.ne.jp; Nishizawa M.) Department of 
Neurology, Brain Research Institute, University of Niigata, Niigata, Japan.
CORRESPONDENCE ADDRESS
  R. Takeuchi, Department of Pathology, Niigata, Japan. Email: 
ryokot5695@wish.ocn.ne.jp
FULL RECORD ENTRY DATE
  2015-12-10
SOURCE
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2015) 16 
SUPPL. 1 (74). Date of Publication: 2015
VOLUME
  16
FIRST PAGE
  74
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  26th International Symposium on ALS/MND
CONFERENCE LOCATION
  Orlando, FL, United States
CONFERENCE DATE
  2015-12-11 to 2015-12-13
ISSN
  2167-8421
BOOK PUBLISHER
  Taylor and Francis Ltd
ABSTRACT
  Case Study: Amyotrophic lateral sclerosis (ALS) may be accompanied by 
frontotemporal dementia (FTD). We report a case of glial mixed tau and 
TDP-43 proteinopathies in a patient diagnosed clinically as having ALS-D. A 
76-year-old Japanese woman became aware of gait disturbance, and 
subsequently developed dysarthria. On examination, she showed atrophy and 
fasciculation in the tongue, a hypoactive gag reflex, and muscle weakness in 
the upper extremities. Increased deep tendon reflexes were also present in 
the upper and lower extremities, with positive Babinski sign in both legs. 
About 10 months after onset, at the age of 77, she was diagnosed as having 
ALS. Her mental performance deteriorated rapidly and a state of apathy 
ensued; at this stage, the clinical diagnosis of ALS-D was made. She also 
suffered from progressive respiratory distress and underwent tracheotomy for 
artificial respiratory support. At the age of 78 years, she eventually 
became bedridden in a totally locked-in state. Brain CT scan performed at 
the age of 81 years revealed frontotemporal atrophy. At the age of 85 years, 
the patient died of septic acute cholecystitis, about 9 years after onset of 
the disease. There were no parkinsonian features during the disease course. 
There had been no family history of ALS, dementia or other neurological 
disease. A general autopsy was performed, at which time the brain weighed 
910 g. Histologically, loss of lower motor neurons and degeneration of the 
pyramidal tracts were evident in the spinal cord and brainstem. The brain 
showed frontotemporal lobar degeneration (FTLD); the most severe neuronal 
loss and gliosis being evident in the precentral gyrus. Although less 
severe, such changes were also observed in other brain regions, including 
the basal ganglia and substantia nigra. AT8 immunostaining revealed that 
predominant occurrence of astrocytic tau lesions termed globular astrocytic 
inclusions (GAIs) was a feature of the affected regions. These GAIs were 
Gallyas- Braak negative. Neuronal and oligodendrocytic tau lesions were 
comparatively scarce. pS409/410 immunostaining also revealed similar 
neuronal and glial TDP-43 lesions. Interestingly, occasional co-localization 
of tau and TDP- 43 was evident in the GAIs. Immunoblot analyses revealed 
band patterns characteristic of a 4-repeat (4R) tauopathy, corticobasal 
degeneration and a TDP-43 proteinopathy, ALS/FTLD-TDP Type B. No mutations 
were found in the MAPT or TDP-43 genes. We consider that this patient 
harbored a distinct, sporadic globular glial mixed 4R tau and TDP-43 
proteinopathy associated with motor neuron disease and FTD.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  frontotemporal dementia; motor neuron disease; TDP 43 proteinopathy; 
EMTREE MEDICAL INDEX TERMS
  acute cholecystitis; amyotrophic lateral sclerosis; apathy; arm; assisted ventilation; atrophy; autopsy; Babinski reflex; basal ganglion; brain; brain region; brain stem; case study; computer assisted tomography; corticobasal degeneration; degeneration; diagnosis; disease course; dysarthria; examination; family history; fasciculation; female; gait; gene; gliosis; human; immobility; immunoblotting; immunohistochemistry; Japanese (people); leg; mental performance; motoneuron; muscle weakness; mutation; neurologic disease; patient; primary motor cortex; pyramidal tract; reflex; respiratory distress; spinal cord; substantia nigra; tauopathy; tendon reflex; tongue; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72104390
DOI
  10.3109/21678421.2015.1098805/003
FULL TEXT LINK
  http://dx.doi.org/10.3109/21678421.2015.1098805/003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21678421&id=doi:10.3109%2F21678421.2015.1098805%2F003&atitle=Globular+glial+mixed+four+repeat+tau+and+TDP-43+proteinopathy+with+motor+neuron+disease+and+frontotemporal+dementia&stitle=Amyotrophic+Lateral+Scler.+Frontotemporal+Degener.&title=Amyotrophic+Lateral+Sclerosis+and+Frontotemporal+Degeneration&volume=16&issue=&spage=74&epage=&aulast=Takeuchi&aufirst=R.&auinit=R.&aufull=Takeuchi+R.&coden=&isbn=&pages=74-&date=2015&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 305
TITLE
  Ruptured spinal arteriovenous malformation: Presenting as stunned myocardium 
and neurogenic shock
AUTHOR NAMES
  Mehesry T.; Shaikh N.; Malmstrom M.; Marcus M.; Khan A.
AUTHOR ADDRESSES
  (Mehesry T., tasneem.saifuddin@gmail.com; Shaikh N., 
nissatfirdous99@gmail.com; Malmstrom M., mmalsstorm@hmc.hamad.qa; Marcus M., 
amarcus@hmc.hamad.qa; Khan A., akhan@hamad.qa) Department of Anesthesia/ICU 
and Perioperative Medicine, Hamad Medical Corporation, Doha, Qatar.
CORRESPONDENCE ADDRESS
  N. Shaikh, Department of Anesthesia/ICU and Perioperative Medicine, Hamad 
Medical Corporation, Doha, Qatar. Email: nissatfirdous99@gmail.com
AiP/IP ENTRY DATE
  2016-03-08
FULL RECORD ENTRY DATE
  2016-03-15
SOURCE
  Surgical Neurology International (2015) 6 Supplement 16 (S424-S427). Date of 
Publication: 1 Dec 2015
VOLUME
  6
FIRST PAGE
  S424
LAST PAGE
  S427
DATE OF PUBLICATION
  1 Dec 2015
ISSN
  2152-7806 (electronic)
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Background: Neurogenic pulmonary edema (NPE) is a clinical syndrome usually 
defined as an acute pulmonary edema occurring shortly after a central 
neurologic insult. NPE was identified 100 years ago, but it is still 
underappreciated in the clinical setup. NPE usually appears within minutes 
to hours after the injury. It has a high mortality rate if not recognized 
early and treated appropriately. Similarly, neurogenic shock is a known 
complication of spinal cord injury reported incidence is more than 20% in 
isolated upper cervical spinal injury. But NPE is rare to occur, and stunned 
myocardium (SM) is not reported in spinal arteriovenous malformation (AVM) 
rupture. SM is a reversible cardiomyopathy resulting in transient left 
ventricular dysfunction which has been described to occur in the setting of 
catecholamine release during situations of physiologic stress. We report a 
case of high spinal AVM rupture presenting as SM, NPE, and neurogenic shock. 
Case Description: A 32-year-old male who presented with sudden onset of pain 
and weakness in upper limbs. Imaging studies showed AVM rupture by imaging 
techniques. Initially, the patient had severe hypertension, respiratory 
distress requiring intubation and ventilation, then he developed 
hypotension, bradycardia, and asystole, which required immediate 
cardiopulmonary resuscitation and atropine. He remained with quadriplegia 
and suffered from frequent episodes of bradycardia and asystole. 
Conclusions: Spinal AVM rupture can present as neurogenic shock, stunned 
myocardium, and pulmonary edema. Early recognition of AVM rupture and prompt 
surgical intervention, as well as aggressive treatment of shock, may enhance 
recovery and decrease the long-term morbidity.
EMTREE DRUG INDEX TERMS
  aminophylline (intravenous drug administration); atropine (drug therapy); dobutamine (intravenous drug administration); dopamine (intravenous drug administration); meropenem (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain arteriovenous malformation (diagnosis, surgery); cervical spine; neurogenic shoxk; neurologic disease; shock; spinal arteriovenous malformation rupture (diagnosis, surgery); stunned heart muscle; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; bradycardia (complication, drug therapy, therapy); brain ventricle; cardiac index; case report; central venous catheterization; clinical feature; computer assisted tomography; disease severity; echocardiography; fever; fluid resuscitation; Glasgow coma scale; Haemophilus infection (diagnosis, drug therapy); Haemophilus influenzae; heart arrest (complication, therapy); heart output; Holter monitoring; human; hypertension; hypokinesia (diagnosis); hypotension (complication, drug therapy); induced hypotension; intensive care; intubation; limb pain; limb weakness; lung edema (diagnosis); male; nuclear magnetic resonance imaging; oxygen desaturation; priority journal; quadriplegia; respiratory distress (therapy); resuscitation; sinus bradycardia (diagnosis); suction; thorax radiography; tracheostomy; transcutaneous pacemaker; treatment response; 
CAS REGISTRY NUMBERS
  aminophylline (317-34-0)
  atropine (51-55-8, 55-48-1)
  dobutamine (34368-04-2, 52663-81-7, 49745-95-1, 61661-06-1)
  dopamine (51-61-6, 62-31-7)
  meropenem (96036-03-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160181950
PUI
  L608755091
DOI
  10.4103/2152-7806.166180
FULL TEXT LINK
  http://dx.doi.org/10.4103/2152-7806.166180
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2F2152-7806.166180&atitle=Ruptured+spinal+arteriovenous+malformation%3A+Presenting+as+stunned+myocardium+and+neurogenic+shock&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=6&issue=&spage=S424&epage=S427&aulast=Mehesry&aufirst=Tasneem&auinit=T.&aufull=Mehesry+T.&coden=&isbn=&pages=S424-S427&date=2015&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 306
TITLE
  Current results of open repair of descending thoracic and thoracoabdominal 
aortic aneurysms
AUTHOR NAMES
  Gaudino M.; Lau C.; Munjal M.; Elsayed M.; Benedetto U.; Girardi L.N.
AUTHOR ADDRESSES
  (Gaudino M.; Lau C.; Munjal M.; Elsayed M.; Benedetto U.; Girardi L.N.) 
Cardio-thoracic Surgery, Weill Cornell Med College, New York, United States.
CORRESPONDENCE ADDRESS
  M. Gaudino, Cardio-thoracic Surgery, Weill Cornell Med College, New York, 
United States.
FULL RECORD ENTRY DATE
  2016-02-08
SOURCE
  Circulation (2015) 132 SUPPL. 3. Date of Publication: 10 Nov 2015
VOLUME
  132
DATE OF PUBLICATION
  10 Nov 2015
CONFERENCE NAME
  American Heart Association's 2015 Scientific Sessions and Resuscitation 
Science Symposium
CONFERENCE LOCATION
  Orlando, FL, United States
CONFERENCE DATE
  2015-11-07 to 2015-11-11
ISSN
  0009-7322
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Open repair of thoracic and thoracoabdominal aortic aneurysms 
(DTA and TAAA respectively) constitutes a benchmark for comparison with 
endovascular techniques. Hypothesis. To evaluate the current results of the 
open repair of DTA and TAAA. Methods. Open DTA and TAAA repair was performed 
on 675 consecutive patients (210 TAA and 465 TAAA). Three surgical 
techniques were used based on the type of the aneurysm and the risk profile 
of the patient: clamp and saw, partial bypass or hypothermic circulatory 
arrest. Spinal drain was used in 82.7% of patients. Regression analysis was 
performed to identify independent determinants of in-hospital and late 
outcomes and individual major postoperative complications. Propensity 
matching (PPM) was used to compare results of the different surgical 
techniques Results. Operative mortality was 5.6% (38/675); incidence of 
postoperative spinal cord injury, stroke, need for tracheostomy, myocardial 
infarction and dialysis were 2.8%, 0.7%, 7.7%, 0.6% and 5.2% respectively. 
Kaplan Mayer survival at five-year was 57.8%. Female gender, urgent 
operation and preoperative dialysis were independent predictors of adverse 
in-hospital adverse events. Preoperative renal and respiratory failure were 
associated with follow-up death. Female gender and preoperative chronic 
pulmonary disease were associated with postoperative need for tracheostomy, 
whereas preoperative renal failure, urgent operation and peripheral vascular 
disease predicted the need for postoperative dialysis. Due to the low number 
of events, logistic regression analysis was not possible for predictors of 
spinal cord injury. In the PPM groups no difference was found in the early 
and late outcome between patients treated with different techniques (see 
table). Conclusion: In the current era open TAA and TAAA repair allows 
excellent outcomes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm; aortic aneurysm; medical society; resuscitation; thoracic aorta; 
EMTREE MEDICAL INDEX TERMS
  cerebrovascular accident; chronic lung disease; clamp; death; dialysis; female; follow up; gender; heart arrest; heart infarction; hospital; human; hypothesis; kidney failure; logistic regression analysis; patient; peripheral vascular disease; postoperative complication; regression analysis; respiratory failure; risk; spinal cord injury; surgical mortality; surgical technique; survival; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72180991
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00097322&id=doi:&atitle=Current+results+of+open+repair+of+descending+thoracic+and+thoracoabdominal+aortic+aneurysms&stitle=Circulation&title=Circulation&volume=132&issue=&spage=&epage=&aulast=Gaudino&aufirst=Mario&auinit=M.&aufull=Gaudino+M.&coden=&isbn=&pages=-&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 307
TITLE
  Surgical Therapy of Cervical Spine Fracture in Patients with Ankylosing 
Spondylitis
AUTHOR NAMES
  Ma J.; Wang C.; Zhou X.; Zhou S.; Jia L.
AUTHOR ADDRESSES
  (Ma J.; Wang C.; Zhou X., zhouxuhui-spine@163.com; Zhou S.; Jia L.) 
Department of Spine Surgery, Changzheng Hospital, Second Military Medical 
University, 415 Fengyang Road, Shanghai, China.
CORRESPONDENCE ADDRESS
  X. Zhou, Department of Spine Surgery, Changzheng Hospital, Second Military 
Medical University, 415 Fengyang Road, Shanghai, China. Email: 
zhouxuhui-spine@163.com
AiP/IP ENTRY DATE
  2016-03-01
FULL RECORD ENTRY DATE
  2016-03-08
SOURCE
  Medicine (United States) (2015) 94:44 (e1663). Date of Publication: 1 Nov 
2015
VOLUME
  94
ISSUE
  44
FIRST PAGE
  e1663
DATE OF PUBLICATION
  1 Nov 2015
ISSN
  1536-5964 (electronic)
  0025-7974
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  The present study aimed to explore surgical treatments and assess the 
effects based on the features of cervical spine fracture in patients with 
ankylosing spondylitis (AS) and to summarize the experiences in 
perioperative management. Retrospective analysis was performed in 25 AS 
patients with cervical spine fracture treated in our hospital from January 
2011 to December 2013. The patients were divided according to fracture 
segments, including 4 cases at C4 to C5, 8 cases at C5 to C6, and 13 cases 
at C6 to C7. Among them, 12 belonged to I type, 5 to II type, and 8 to III 
type based on the improved classification method for AS cervical spine 
fracture. The Subaxial Cervical Spine Injury Classification score for these 
patients was 7.2 ± 1.3, and the assessment of their neurological function 
states showed 6 patients (24%) were in American Spinal Injury Association 
(ASIA) A grade, 1 (4%) in ASIA B grade, 3 (12%) in ASIA C grade, 12 (48%) in 
ASIA D grade, and 3 (12%) in ASIA E grade. Surgical methods contained simple 
anterior approach alone, posterior approach alone, and combined 
posterior-anterior or anterior-posterior approach. The average duration of 
patients' hospital stay was 38.6 ± 37.6, and the first surgical methods were 
as follows: anterior approach alone on 6 cases, posterior surgery alone on 9 
cases, and combined posterior-anterior or anterior-posterior approach on 10 
patients. The median segments of fixation and fusion were 4.1 ± 1.4 
sections. Thirteen patients developed complications. During 2 to 36 months 
of postoperative follow-up, 1 patient died of respiratory failure caused by 
pulmonary infections 2 months after leaving hospital. At the end of the 
follow-up, bone graft fusion was achieved in the rest of patients, and 
obvious looseness or migration of internal fixation was not observed. In 
addition, the preoperative neurological injury in 12 patients (54.5%) was 
also alleviated in different levels. AS cervical spine fracture, an unstable 
fracture, should be treated with operation, and satisfactory effects will be 
achieved after the individualized surgical treatment according to the 
improved classification method for AS cervical spine fracture.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis (surgery); cervical spine fracture (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; bone transplantation; cause of death; clinical article; cognition; conservative treatment; decubitus (complication); disease association; esophagus injury (complication); female; hospitalization; human; intervertebral disk; length of stay; lung infection (complication); male; middle aged; operation duration; osteosynthesis; perioperative period; postoperative complication (complication); priority journal; respiratory failure (complication); screw loosening (complication); tracheotomy; urinary tract infection (complication); vertebra body; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160143674
MEDLINE PMID
  26554765 (http://www.ncbi.nlm.nih.gov/pubmed/26554765)
PUI
  L608482314
DOI
  10.1097/MD.0000000000001663
FULL TEXT LINK
  http://dx.doi.org/10.1097/MD.0000000000001663
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15365964&id=doi:10.1097%2FMD.0000000000001663&atitle=Surgical+Therapy+of+Cervical+Spine+Fracture+in+Patients+with+Ankylosing+Spondylitis&stitle=Medicine&title=Medicine+%28United+States%29&volume=94&issue=44&spage=e1663&epage=&aulast=Ma&aufirst=Jun&auinit=J.&aufull=Ma+J.&coden=MEDIA&isbn=&pages=e1663-&date=2015&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 308
TITLE
  Historical Vignette of Infamous Gunshot Injury to Spine: "an Ailment not to 
be Treated"?
AUTHOR NAMES
  Maiti T.K.; Konar S.; Bir S.C.; Bollam P.; Nanda A.
AUTHOR ADDRESSES
  (Maiti T.K.; Konar S.; Bir S.C.; Bollam P.; Nanda A., ananda@lsuhsc.edu) 
Department of Neurosurgery, Louisiana State University Health-Shreveport, 
Shreveport, United States.
CORRESPONDENCE ADDRESS
  A. Nanda, Department of Neurosurgery, Louisiana State University 
Health-Shreveport, Shreveport, United States.
AiP/IP ENTRY DATE
  2015-11-17
FULL RECORD ENTRY DATE
  2015-11-18
SOURCE
  World Neurosurgery (2015) 84:5 (1441-1446). Date of Publication: 1 Nov 2015
VOLUME
  84
ISSUE
  5
FIRST PAGE
  1441
LAST PAGE
  1446
DATE OF PUBLICATION
  1 Nov 2015
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  The increasing prevalence and gloomy socioeconomic consequence of spine 
injury remain a concern in modern medicine. In this article, we highlight 
the infamous gunshot spinal injuries of a few eminent personalities across 
multiple centuries and their sociopolitical impact in context with the 
evolution of modern medicine. The role of available medicine in these 
victims was not more than a mere watcher, thus substantiating an infamous 
quote from ancient literature that describes spine injury as "an ailment not 
to be treated."
EMTREE DRUG INDEX TERMS
  rose oil; turpentine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gunshot injury; gunshot spinal injury; spine injury; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; article; blood transfusion; bullet; computer assisted tomography; egg yolk; homicide; human; medical history; mortality; nuclear magnetic resonance imaging; politics; psychosurgery; socioeconomics; spine fracture; suicide attempt; surgical glove; tracheostomy; vertebra dislocation; wound drainage; 
CAS REGISTRY NUMBERS
  rose oil (8007-01-0)
  turpentine (9005-90-7)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015504607
MEDLINE PMID
  25836272 (http://www.ncbi.nlm.nih.gov/pubmed/25836272)
PUI
  L606851300
DOI
  10.1016/j.wneu.2015.03.037
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2015.03.037
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2015.03.037&atitle=Historical+Vignette+of+Infamous+Gunshot+Injury+to+Spine%3A+%22an+Ailment+not+to+be+Treated%22%3F&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=84&issue=5&spage=1441&epage=1446&aulast=Maiti&aufirst=Tanmoy+Kumar&auinit=T.K.&aufull=Maiti+T.K.&coden=&isbn=&pages=1441-1446&date=2015&auinit1=T&auinitm=K
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 309
TITLE
  Chronic lymphocytic inflammation with pontine perivascular enhancement 
responsive to steroids with a significant elevation of β-2 microglobulin 
levels
AUTHOR NAMES
  Fujisawa N.; Oya S.; Mori H.; Matsui T.
AUTHOR ADDRESSES
  (Fujisawa N.; Oya S., sooya-tky@umin.ac.jp; Matsui T.) Department of 
Neurosurgery, Saitama Medical Center, Saitama Medical University, Saitama, 
Japan.
(Mori H.) Department of Radiology, Graduate School of Medicine, University 
of Tokyo, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  S. Oya, Department of Neurosurgery, Saitama Medical Center, Saitama Medical 
University, Kamoda 1981, Kawagoe, Japan. Email: sooya-tky@umin.ac.jp
AiP/IP ENTRY DATE
  2015-12-22
FULL RECORD ENTRY DATE
  2015-12-23
SOURCE
  Journal of Korean Neurosurgical Society (2015) 58:5 (487-490). Date of 
Publication: 1 Nov 2015
VOLUME
  58
ISSUE
  5
FIRST PAGE
  487
LAST PAGE
  490
DATE OF PUBLICATION
  1 Nov 2015
ISSN
  1598-7876 (electronic)
  2005-3711
BOOK PUBLISHER
  Korean Neurosurgical Society, JKNS@paran.com
ABSTRACT
  Chronic lymphocytic inflammation with pontine perivascular enhancement 
responsive to steroids (CLIPPERS) is a relapsing-remitting disorder for 
which steroid administration is a key to control the progression. CLIPPERS 
can exhibit radiological features similar to malignant lymphoma, whose 
diagnosis is confounded by prior steroid administration. We report a case of 
CLIPPERS accompanied by abnormal elevation of β-2 microglobulin in the 
cerebrospinal fluid (CSF). A 62-year-old man started to experience numbness 
in all fingers of his left hand one year ago, which gradually extended to 
his body trunk and legs on both sides. Magnetic resonance imaging 
demonstrated numerous small enhancing spots scattered in his brain and 
spinal cord. CSF levels of β-2 microglobulin were elevated; although this 
often indicates central nervous system involvement in leukemia and lymphoma, 
the lesions were diagnosed as CLIPPERS based on the pathological findings 
from a biopsy specimen. We emphasize the importance of biopsy to 
differentiate between CLIPPERS and malignant lymphoma because the temporary 
radiological response to steroid might be the same in both diseases but the 
treatment strategies regarding the use of steroid are quite different.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  beta 2 microglobulin (endogenous compound); steroid; 
EMTREE DRUG INDEX TERMS
  lactate dehydrogenase (endogenous compound); methylprednisolone (drug therapy, intravenous drug administration); prednisone (drug therapy, oral drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  central nervous system disease (drug therapy, diagnosis, drug therapy); chronic lymphocytic inflammation with pontine perivascular enhancement 
responsive to steroids (drug therapy, diagnosis, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; brain damage (diagnosis); case report; cerebellar ataxia; cerebrospinal fluid analysis; drug dose reduction; dysarthria; dysphagia; human; human tissue; immunohistochemistry; male; middle aged; neurologic examination; nuclear magnetic resonance imaging; paresthesia; respiratory distress; tracheostomy; 
CAS REGISTRY NUMBERS
  beta 2 microglobulin (9066-69-7)
  lactate dehydrogenase (9001-60-9)
  methylprednisolone (6923-42-8, 83-43-2)
  prednisone (53-03-2)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20151029229
PUI
  L607256792
DOI
  10.3340/jkns.2015.58.5.487
FULL TEXT LINK
  http://dx.doi.org/10.3340/jkns.2015.58.5.487
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15987876&id=doi:10.3340%2Fjkns.2015.58.5.487&atitle=Chronic+lymphocytic+inflammation+with+pontine+perivascular+enhancement+responsive+to+steroids+with+a+significant+elevation+of+%CE%B2-2+microglobulin+levels&stitle=J.+Korean+Neurosurg.+Soc.&title=Journal+of+Korean+Neurosurgical+Society&volume=58&issue=5&spage=487&epage=490&aulast=Fujisawa&aufirst=Naoaki&auinit=N.&aufull=Fujisawa+N.&coden=&isbn=&pages=487-490&date=2015&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 310
TITLE
  Perspective from spinal muscular atrophy families: Care of a child with 
tracheostomy and home mechanical ventilatory support
AUTHOR NAMES
  Tanyildiz M.; Topaloʇlu H.; Oncel I.; Bayrakci B.; Haliloglu G.
AUTHOR ADDRESSES
  (Tanyildiz M.; Topaloʇlu H.; Oncel I.; Bayrakci B.; Haliloglu G.) Hacettepe 
Children's Hospital, Ankara, Turkey.
CORRESPONDENCE ADDRESS
  H. Topaloʇlu, Hacettepe Children's Hospital, Ankara, Turkey.
FULL RECORD ENTRY DATE
  2016-01-27
SOURCE
  Neuromuscular Disorders (2015) 25 SUPPL. 2 (S192). Date of Publication: 
October 2015
VOLUME
  25
FIRST PAGE
  S192
DATE OF PUBLICATION
  October 2015
CONFERENCE NAME
  20th International Congress of The World Muscle Society
CONFERENCE LOCATION
  Brighton, United Kingdom
CONFERENCE DATE
  2015-10-01 to 2015-10-04
ISSN
  0960-8966
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  Management of pulmonary disease and respiratory failure in spinal muscular 
atrophy (SMA) is challenging depending on social and cultural issues. 
Exploring options with the individual family in terms of the patients' 
potential, quality of life and family's desires is essential. We 
retrospectively analyzed 30 SMA patients (Girls: 15, Boys: 15) followed due 
to acute/chronic respiratory failure in the Pediatric Intensive Care Unit 
(PICU) between 2002 and 2014. As a first step, medical records of all 
patients, and reflections from 21 of the families by phone call were 
reviewed. As a second step, we evaluated pediatric quality of life 
(PedsQLTM) inventory and Beck depression inventory from 8 families of the 
already alive 10 SMA patients. Twenty-nine patients had a genetically 
confirmed diagnosis including SMA Type I (n = 26), SMA Type II (n = 2), and 
SMARD (n = 1). Mean age at the time of diagnosis was 4 months (intrauterine 
- 36 months). 22 out of 30 patients had tracheostomy. To date, 10 out of 21 
reached patients are alive with a mean age of 3.4 years (20 months-8 years). 
All of the surviving patients are on home-mechanical ventilation. Feeding 
was via nasogastric tube (n = 3) and gastrostomy (n = 5). All of the 
patients receive regular chest and physical therapy. Eight of 10 surviving 
patients use home care health services provided by Ministry of Health. 
PedsQL inventory and Beck depression inventory in 8 families showed that 
despite the poor parental quality of life status, families have no 
depressive symptoms except one. All the parents expressed that living with a 
child with SMA is difficult, but they learned to cope with it in time. 
Invasive procedures for SMA type I is a challenging decision. Our results 
show that families develop a complex coping mechanism including a multilevel 
medical care. Familial characteristics further deserve attention in the era 
of up-coming potential treatment options.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child; human; muscle; society; spinal muscular atrophy; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; Beck Depression Inventory; boy; coping behavior; depression; diagnosis; feeding; female; gastrostomy; girl; health; health service; home care; intensive care unit; invasive procedure; lung disease; male; medical care; medical record; nasogastric tube; parent; patient; physiotherapy; quality of life; respiratory failure; thorax; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72163771
DOI
  10.1016/j.nmd.2015.06.034
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nmd.2015.06.034
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09608966&id=doi:10.1016%2Fj.nmd.2015.06.034&atitle=Perspective+from+spinal+muscular+atrophy+families%3A+Care+of+a+child+with+tracheostomy+and+home+mechanical+ventilatory+support&stitle=Neuromuscular+Disord.&title=Neuromuscular+Disorders&volume=25&issue=&spage=S192&epage=&aulast=Tanyildiz&aufirst=M.&auinit=M.&aufull=Tanyildiz+M.&coden=&isbn=&pages=S192-&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 311
TITLE
  Prolonged orotracheal intubation
AUTHOR NAMES
  Rajagopal A.; Hirschowitz E.A.; Wallace T.
AUTHOR ADDRESSES
  (Rajagopal A.; Hirschowitz E.A.; Wallace T.) University of Kentucky at 
Lexington, Lexington, United States.
CORRESPONDENCE ADDRESS
  A. Rajagopal, University of Kentucky at Lexington, Lexington, United States.
FULL RECORD ENTRY DATE
  2015-11-05
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2015) 191 
MeetingAbstracts. Date of Publication: 2015
VOLUME
  191
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2015
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2015-05-15 to 2015-05-20
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  While timely exubation or conversion to tracheostomy are often early goals, 
data on prolonged orotracheal intubation is limited. We report and present a 
case of prolonged orotracheal intubation, greater than 73 days, without 
change in endotracheal tube. 64-year-old male patient with multiple medical 
problems including end-stage-COPD and ischemic systolic and diastolic heart 
failure (EF<20%) presented in acute hypoxic hypercapnic respiratory failure 
secondary to pulmonary edema. He had marked and fixed cervical kyphosis and 
had suffered traumatic injury to c-spine in a logging accident. As a result, 
he cannot extend his neck. He has very limited lateral bending and rotation 
to just a few degrees. He was successfully intubated, however multiple 
attempts at extubation were unsuccessful due to reaccumulation of fluid in 
his lungs secondary to heart failure. He was subsequently evaluated for a 
tracheostomy by ear-nose-throat, cardiothoracic surgery, and general surgery 
teams who were in agreement that he was not a candidate for tracheostomy 
secondary to his fixed cervical spine and intrathoracic trachea. On physical 
exam, the trachea was displaced posteriorly and inferiorly, the thyroid 
notch was palpable in his sternal notch and the cricothyroid membrane 
palapable with swallowing. However, in order to place a tracheostomy he 
would need a portion of his sternum and clavicular heads removed to gain 
access to the trachea. The risks/morbidity of this procedure outweighed the 
benefit. It was determined that the patient would remain intubated with the 
size 8 endotracheal tube. Approximately 30 days into the intubation an air 
leak developed and the patient declined any tube changes. There are episodes 
of periodic mucous plugging with possible anoxic brain injury. He continues 
to be supported by orotracheal intubation at day 73. Complications of 
prolonged orotracheal intubation are numerable and can include infection, 
tracheal stenosis, esophageal erosion, and innominate artery fistulization. 
While the risk of complication is present, keeping the tube in place may 
prolong life when tracheostomy is not an option. While early extubation is 
preferable it is not always feasible. As was the case in our patient, some 
cases are not ammenable to tracheostomy. In these cases, terminal extubation 
may not be the only option.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; endotracheal intubation; society; 
EMTREE MEDICAL INDEX TERMS
  accident; brachiocephalic trunk; brain injury; cervical spine; diastolic heart failure; ear; endotracheal tube; extubation; general surgery; heart failure; human; infection; injury; intubation; kyphosis; liquid; logging; lung; lung edema; male; membrane; neck; nose; patient; procedures; respiratory failure; risk; spine; sternum; swallowing; thorax surgery; throat; thyroid gland; trachea; trachea stenosis; tracheostomy; tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72050999
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Prolonged+orotracheal+intubation&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=191&issue=&spage=&epage=&aulast=Rajagopal&aufirst=A.&auinit=A.&aufull=Rajagopal+A.&coden=&isbn=&pages=-&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 312
TITLE
  Outcomes of children with type 1 spinal muscular atrophy who were ventilator 
dependent at home
AUTHOR NAMES
  Cristea A.; Harris J.M.; Shelley D.; Ackerman V.
AUTHOR ADDRESSES
  (Cristea A., aicriste@iupui.edu; Harris J.M.; Shelley D.; Ackerman V.) Riley 
Hospital for Children, Indiana University Health, Indianapolis, United 
States.
CORRESPONDENCE ADDRESS
  A. Cristea, Riley Hospital for Children, Indiana University Health, 
Indianapolis, United States. Email: aicriste@iupui.edu
FULL RECORD ENTRY DATE
  2015-11-05
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2015) 191 
MeetingAbstracts. Date of Publication: 2015
VOLUME
  191
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2015
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2015-05-15 to 2015-05-20
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction Data describing health outcomes of children with Type 1 Spinal 
Muscular Atrophy (SMA) originates from countries where tracheostomy and/or 
chronic ventilation are not routinely offered. There is significant debate 
in the medical literature regarding the ethics of the decision to offer 
chronic ventilation to these patients. To our knowledge there is limited 
information regarding long term outcomes of these children who receive care 
within the US healthcare system. Methods We retrospectively reviewed charts 
of patients with type 1 SMA who were ventilator dependent at home and who 
were enrolled in a university-affiliated home ventilator program between 
1985 and 2014. Results During this interval, eleven children with type 1 SMA 
were cared for in our home ventilator program. Of these, six were males, 
seven were Caucasian and three were African American. All patients were in 
their biological parents' care. One patient was later placed in an extended 
care skilled facility after the death of his primary caregiver. All families 
were offered the choice of palliative care at time of diagnosis with one 
exception, when the tracheostomy was placed before the diagnosis was made. 
There were 63 readmissions among the group (range: 3 - 16 
admissions/patient) with a median length of stay of 19 days (range: 6 - 
116). Comorbidities encountered in this group include kyphoscoliosis (11), 
hypertension (2), inflammatory bowel disease (2), depression (4) and 
hirisutism (1). Three patients survived cardiopulmonary arrest at home after 
a tracheostomy catastrophic event or ventilator disconnect. Five patients 
died, at a median age of 7.9 years (range: 3.1 - 14.6). The remaining six 
are alive, with a median age of 22.1 years (range: 1.19 - 27.3). Conclusions 
Children with type 1 SMA who are electively placed on home ventilation via 
tracheostomy may survive for a long time. Families and caregivers who are 
considering long term chronic ventilation for a child with Type 1 SMA need 
better information regarding the potential long life expectancy and multiple 
complications encountered in this population in order to make better quality 
of life decisions for their child.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; child; human; society; spinal muscular atrophy; ventilator; 
EMTREE MEDICAL INDEX TERMS
  African American; air conditioning; cardiopulmonary arrest; caregiver; Caucasian; death; diagnosis; ethics; health; health care system; hospital readmission; hypertension; inflammatory bowel disease; kyphoscoliosis; length of stay; life expectancy; male; medical literature; palliative therapy; parent; patient; population; quality of life; tracheostomy; university; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72050613
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Outcomes+of+children+with+type+1+spinal+muscular+atrophy+who+were+ventilator+dependent+at+home&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=191&issue=&spage=&epage=&aulast=Cristea&aufirst=A.&auinit=A.&aufull=Cristea+A.&coden=&isbn=&pages=-&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 313
TITLE
  Cardiovascular collapse during spinal anesthesia
AUTHOR NAMES
  Zakhary B.; Coritsidis G.
AUTHOR ADDRESSES
  (Zakhary B., bzakhary@gmail.com) NYU Medical Center, New York, United 
States.
(Zakhary B., bzakhary@gmail.com; Coritsidis G.) Elmhurst Hospital Center/ 
Mount Sinai, School of Medicine, Elmhurst, United States.
CORRESPONDENCE ADDRESS
  B. Zakhary, NYU Medical Center, New York, United States. Email: 
bzakhary@gmail.com
FULL RECORD ENTRY DATE
  2015-11-05
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2015) 191 
MeetingAbstracts. Date of Publication: 2015
VOLUME
  191
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2015
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2015-05-15 to 2015-05-20
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  INTRODUCTION Cardiac arrest during spinal anesthesia is a relatively rare 
event. The pathogenesis is incompletely understood but likely involves the 
loss of sympathetic tone. We report a case of spinal anesthesia complicated 
by cardiac arrest. CASE PRESENTATION A 32 year old healthy male was brought 
in after sustaining a gun-shot wound to the right lower extremity. In the 
trauma bay, the patient was awake and interactive with a Glasgow Coma Scale 
score of fifteen. On examination, he had an entry wound in the right 
posterior knee. Imaging demonstrated a fractured right patella with multiple 
bullet fragments. The patient was scheduled for surgical debridement. In the 
operating room, the patient received spinal anesthesia at the lumbar level. 
Within ten minutes, he was noted to be hypotensive then quickly apneic and 
unresponsive. Rhythm monitor demonstrated pulseless electrical activity. The 
patient was intubated with initiation of advanced cardiac life support. He 
required two rounds of epinephrine with subsequent return of spontaneous 
circulation. The patient was transferred to the surgical intensive care 
unit. Over the next several days, the patient had a poor neurological 
recovery, ultimately requiring percutaneous tracheostomy and gastrostomy 
tubes. DISCUSSION Cardiac arrest during spinal anesthesia is a relatively 
rare event with an incidence of about 0.07%. Although the mechanism is not 
clearly defined, it is believed that there is superior migration of the 
anesthetic with subsequent loss of sympathetic tone. Risk factors associated 
with subsequent circulatory arrest include high basal parasympathetic tone, 
low blood volume prior to anesthesia, and rapid progression of spinal 
blockade. The Bezold-Jarisch reflex (a cardio-inhibitory reflex in response 
to an underfilled ventricle leading to bradycardia, hypotension, and apnea) 
may also play a role. Clinical findings include hypotension (secondary to 
vasodilation and reduced venous return) and bradycardia (secondary to loss 
of the cardio-accelerator fibers arising from T1-4 and to the Bezold-Jarish 
reflex) resulting in reduced cardiac output and possibly cardiac arrest. 
Respiratory arrest may also be seen. Treatment is primarily supportive and 
includes aggressive volume resuscitation with pressor and inotropic support 
as needed. Ventilatory support is also often required. CONCLUSION Spinal 
anesthesia can be complicated by circulatory collapse and respiratory 
failure. Although rare, this case highlights that the clinical presentation 
can be dramatic and requires immediate recognition and aggressive support.
EMTREE DRUG INDEX TERMS
  anesthetic agent; antihypertensive agent; epinephrine; hypertensive factor; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; shock; society; spinal anesthesia; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; apnea; bay; blood volume; bradycardia; bullet; debridement; electric activity; examination; fiber; Glasgow coma scale; gunshot injury; heart arrest; heart output; human; hypotension; imaging; injury; inotropism; intensive care unit; knee; leg; male; operating room; parasympathetic tone; patella; pathogenesis; patient; reflex; respiratory arrest; respiratory failure; resuscitation; return of spontaneous circulation; rhythm; risk factor; stomach tube; sympathetic tone; tracheostomy; vasodilatation; venous return; wound; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72052502
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Cardiovascular+collapse+during+spinal+anesthesia&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=191&issue=&spage=&epage=&aulast=Zakhary&aufirst=B.&auinit=B.&aufull=Zakhary+B.&coden=&isbn=&pages=-&date=2015&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 314
TITLE
  Cervical anterior spinal cord syndrome following pulmonary artery rupture 
during a left and right heart catheterization: A rare but significant 
complication
AUTHOR NAMES
  Niccum D.; Dincer H.; Arndt P.
AUTHOR ADDRESSES
  (Niccum D.; Dincer H.; Arndt P.) University of Minnesota, Minneapolis, 
United States.
CORRESPONDENCE ADDRESS
  D. Niccum, University of Minnesota, Minneapolis, United States.
FULL RECORD ENTRY DATE
  2015-11-05
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2015) 191 
MeetingAbstracts. Date of Publication: 2015
VOLUME
  191
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2015
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2015-05-15 to 2015-05-20
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Anterior spinal cord infarction is a rare procedural 
complication, particularly after cardiac catheterization. Previous reports 
of anterior spinal cord infarction after heart catheterization involved only 
patients undergoing left heart catherization and affected the lower spinal 
cord levels of L1, L2 , or conus medularis. The pathophysiology of ischemia 
was attributed to the rupture and embolism of pre-existing atherosclerotic 
plaques upon manipulation of the aorta during endovascular procedures. A 
much rarer presentation is anterior spinal cord infarction after right heart 
catheterization (RHC). Case: A 74-year-old female with history of OSA and 
spinal stenosis underwent a right and left cardiac catheterization via right 
femoral approach for evaluation of pulmonary hypertension. Coronary 
angiography demonstrated clear coronary arteries. On RHC, pulmonary artery 
systolic pressure (68 mm Hg) and wedge pressure (25 mm Hg) were found to be 
elevated. Upon inflation of the balloon in wedge position, she developed 
coughing with frank hemoptysis requiring intubation. Given the copious 
amounts of blood suctioned from her airway and unilateral circumscribed 
alveolar opacification on chest x-ray, she was diagnosed with a ruptured 
pulmonary artery. Two days later she was found to have paralysis of all four 
extremities though she was able to lift her head to command. She had intact 
sensation throughout but flaccid paralysis below the neck. MRI of the head 
and cervical spine revealed severe cervical spinal stenosis but no evidence 
of compression. Electromyography ruled out peripheral neuropathy. Lumbar 
puncture revealed no evidence of Guillain-Barre syndrome. Given these 
findings, the diagnosis of anterior spinal cord infarction was made. Over 
the ensuing month she had no neurological improvement and subsequently 
required tracheostomy before transferring to a rehab/long term care center. 
Discussion: This case is unique due to its involvement of the cervical 
spinal cord and onset after RHC; likely due to pulmonary artery rupture, in 
itself a rare complication of RHC. The association between these two 
complications can most easily be explained by the embolism of air or 
thrombus via collateral circulation between the pulmonary artery and 
bronchial (systemic) circulation at the time of the pulmonary rupture. Less 
likely mechanisms include an independent complication due to arterial plaque 
rupture on left heart catheterization or watershed infarct due to transient 
hypotension as previously described following coronary artery bypass 
surgeries. While one prior case of anterior spinal cord infarct has been 
described post pulmonary artery injury, this is the first report following 
right heart catheterization.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; artery rupture; heart catheterization; pulmonary artery; society; spinal cord; 
EMTREE MEDICAL INDEX TERMS
  airway; angiocardiography; aorta; artery injury; atherosclerotic plaque; blood; cervical spinal cord; cervical spine; collateral circulation; compression; coronary artery; coronary artery bypass surgery; coughing; diagnosis; electromyography; embolism; endovascular surgery; female; flaccid paralysis; Guillain Barre syndrome; hemoptysis; human; hypotension; infarction; intubation; ischemia; lumbar puncture; neck; nuclear magnetic resonance imaging; paralysis; pathophysiology; patient; peripheral neuropathy; pulmonary hypertension; rupture; sensation; spinal cord infarction; systolic blood pressure; thorax radiography; thrombus; tracheostomy; vertebral canal stenosis; watershed; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72052767
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Cervical+anterior+spinal+cord+syndrome+following+pulmonary+artery+rupture+during+a+left+and+right+heart+catheterization%3A+A+rare+but+significant+complication&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=191&issue=&spage=&epage=&aulast=Niccum&aufirst=D.&auinit=D.&aufull=Niccum+D.&coden=&isbn=&pages=-&date=2015&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 315
TITLE
  Bronchial artery embolization as a cause of myocardial infarction
AUTHOR NAMES
  Dhungana S.; Ali M.M.; Maskey A.
AUTHOR ADDRESSES
  (Dhungana S., san_iom@yahoo.com; Ali M.M.; Maskey A.) University of 
Kentucky, Lexington, United States.
CORRESPONDENCE ADDRESS
  S. Dhungana, University of Kentucky, Lexington, United States. Email: 
san_iom@yahoo.com
FULL RECORD ENTRY DATE
  2015-11-05
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2015) 191 
MeetingAbstracts. Date of Publication: 2015
VOLUME
  191
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2015
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2015-05-15 to 2015-05-20
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  A 26 year old male with cystic fibrosis presented to the ED with massive 
hemoptysis following a coughing spell. He was emergently intubated for 
airway protection. A CT angiogram didn't reveal any extravasation of dye. 
Bronchoscopy revealed bleeding from the left lower lobe. After epinephrine 
and thrombin injection failed, the left lobe was isolated using an Arndt 
endobronchial blocker. Pt was transferred to the interventional radiology 
(IR) suite where he underwent embolization of the superior and inferior 
divisions of the left bronchial artery using microspheres. During the 
procedure, he developed visible ST elevation on the monitor. A stat EKG was 
concerning for acute inferior ST elevation MI. An emergent left heart 
catheterization revealed lack of flow in the distal posterolateral branch of 
the left circumflex vessel. The patient underwent unsuccessful balloon 
angioplasty of the culprit vessel. He continued to bleed and was taken back 
to the IR suite, where successful embolization of the left superior 
bronchial artery was done, with resolution of hemoptysis. The patient 
however went into profound septic shock and ARDS. He subsequently underwent 
tracheostomy in anticipation of prolonged mechanical ventilation. After two 
weeks, the patient started bleeding profusely again, raising the specter of 
trachea-innominate fistula. A CT angiogram of neck and chest confirmed the 
absence of a fistula, but revealed a third bronchial artery arising from the 
pericardiophrenic branch of the right internal mammary artery, as well as a 
6 mm pseudoaneurysm involving the posterobasal segment of the left lower 
lobe. The patient was taken back to the IR suite, and embolization was 
performed on the right pericardiophrenic artery as well as the posterior 
basal segment of the left pulmonary artery, which was feeding the 
pseudoaneusym. The patient subsequently stopped bleeding. He had a prolonged 
hospital course due to inability to wean, and was transferred to a long term 
acute care hospital. stemi with bronchial artery embolization.jpg DISCUSSION 
Bronchial artery embolization (BA) is an established therapy for massive 
hemoptysis1. Complications of the procedure include chest pain, dysphagia, 
posterior circulation stroke, spinal cord infarction2, systemic 
embolization, etc. Collaterals between the bronchial artery and coronary 
arteries have been described3. Caution is advised to rule out such 
collaterals before embolization. We describe the first case of MI following 
BAE in US.
EMTREE DRUG INDEX TERMS
  dye; epinephrine; microsphere; thrombin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; artificial embolization; bronchial artery; heart infarction; society; 
EMTREE MEDICAL INDEX TERMS
  adult respiratory distress syndrome; airway; artery; artificial ventilation; bleeding; bronchoscopy; cerebrovascular accident; coronary artery; coughing; cystic fibrosis; dysphagia; emergency care; endobronchial blocker; extravasation; false aneurysm; feeding; fistula; heart catheterization; hemoptysis; hospital; human; injection; internal mammary artery; interventional radiology; male; neck; patient; percutaneous transluminal angioplasty; procedures; protection; pulmonary artery; septic shock; spinal cord; ST segment elevation; ST segment elevation myocardial infarction; therapy; thorax; thorax pain; trachea; tracheostomy; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72054108
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Bronchial+artery+embolization+as+a+cause+of+myocardial+infarction&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=191&issue=&spage=&epage=&aulast=Dhungana&aufirst=S.&auinit=S.&aufull=Dhungana+S.&coden=&isbn=&pages=-&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 316
TITLE
  'Survey of clinicians' experience and attitudes regarding spinal muscular 
atrophy with respiratory distress syndrome type 1 (SMARD1) in the UK
AUTHOR NAMES
  Shah S.; Jerrom T.; Fraser J.; Majumdar A.
AUTHOR ADDRESSES
  (Shah S.; Jerrom T.; Fraser J.; Majumdar A.) Bristol Children's Hospital, 
Bristol, United Kingdom.
CORRESPONDENCE ADDRESS
  A. Majumdar, Bristol Children's Hospital, Bristol, United Kingdom.
FULL RECORD ENTRY DATE
  2016-01-27
SOURCE
  Neuromuscular Disorders (2015) 25 SUPPL. 2 (S226). Date of Publication: 
October 2015
VOLUME
  25
FIRST PAGE
  S226
DATE OF PUBLICATION
  October 2015
CONFERENCE NAME
  20th International Congress of The World Muscle Society
CONFERENCE LOCATION
  Brighton, United Kingdom
CONFERENCE DATE
  2015-10-01 to 2015-10-04
ISSN
  0960-8966
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  SMARD1 is a rare progressive neurological condition seen in infants and 
caused by an autosomal recessive mutation of the IGHMBP2 gene. The major 
clinical features include respiratory distress progressing to ventilatory 
failure, diaphragmatic eventration or paralysis and a progressive distal 
muscular weakness. Due to the rarity of SMARD1 there is currently little 
consensus regarding appropriate treatment. To help provide more standardised 
care for children with this condition we carried out an online survey in 
April 2012 to investigate clinician's experiences and attitudes regarding 
treatment of SMARD1. We distributed a survey to 601 Paediatric Consultants 
via four specialist interest groups (intensivists, neurologists, respiratory 
and generalists) based in the UK. The survey had eight questions, and posed 
a series of ethical and clinical dilemmas. In total we received 80 responses 
(13.3%, n = 80/601) of which 36.3% were Neurologists (n = 29/80), 25% 
Intensivists (n = 20/80), 6.3% Respiratory (n = 5/80) and 32.4% were General 
Paediatrics (n = 26/80). When asked about long term treatment, 47.9% would 
offer extubation followed by palliative care, 14.1% would advocate Long Term 
Tracheostomy Home Ventilation (LTTHV), and 38% would offer both. Consultants 
with less than 10 years of experience and those who had not previously cared 
for a child with SMARD1 were more likely to recommend extubation followed by 
palliative care. Reasons for treatment: 45.1% (n = 32/71) cited parental 
wishes, and 35.2% (n = 25/71) cited the expectation that the child might 
have several years of good quality life. Reasons for not offering children 
with SMARD1 LTTHV were: unacceptably poor quality of life on LTTHV (54.9%, n 
= 39/71), the burden of care placed upon carers (42.3%, n = 30/71) and 
assumed short life expectancy despite LTTHV (35.2%, n = 25/71). Our study 
shows that a minority of clinicians would advocate LTTHV for children with 
SMARD1. Motivating factors for decision making was different by speciality.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  muscle; respiratory distress syndrome; society; spinal muscular atrophy; United Kingdom; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; autosomal recessive inheritance; caregiver; child; clinical feature; consensus; consultation; decision making; diaphragm eventration; extubation; gene; human; infant; intensivist; life expectancy; long term care; medical specialist; muscle weakness; mutation; neurologist; palliative therapy; paralysis; pediatrics; quality of life; respiratory distress; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72163888
DOI
  10.1016/j.nmd.2015.06.151
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nmd.2015.06.151
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09608966&id=doi:10.1016%2Fj.nmd.2015.06.151&atitle=%27Survey+of+clinicians%27+experience+and+attitudes+regarding+spinal+muscular+atrophy+with+respiratory+distress+syndrome+type+1+%28SMARD1%29+in+the+UK&stitle=Neuromuscular+Disord.&title=Neuromuscular+Disorders&volume=25&issue=&spage=S226&epage=&aulast=Shah&aufirst=S.&auinit=S.&aufull=Shah+S.&coden=&isbn=&pages=S226-&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 317
TITLE
  Mycobacterium avium complex (MAC) sepsis in an immunocompetent patient 
isolated from routine blood culture
AUTHOR NAMES
  Khan F.; Naab T.; Geleta M.
AUTHOR ADDRESSES
  (Khan F.; Naab T.; Geleta M.) Howard University Hospital, United States.
CORRESPONDENCE ADDRESS
  F. Khan, Howard University Hospital, United States.
FULL RECORD ENTRY DATE
  2016-01-27
SOURCE
  American Journal of Clinical Pathology (2015) 144 SUPPL. 2 (A229). Date of 
Publication: October 2015
VOLUME
  144
FIRST PAGE
  A229
DATE OF PUBLICATION
  October 2015
CONFERENCE NAME
  2015 American Society for Clinical Pathology, ASCP Annual Meeting
CONFERENCE LOCATION
  Long Beach, CA, United States
CONFERENCE DATE
  2015-10-28 to 2015-10-30
ISSN
  0002-9173
BOOK PUBLISHER
  American Society of Clinical Pathologists
ABSTRACT
  Mycobacterium avium complex (MAC) includes Mycobacterium avium and 
Mycobacterium intracellulare. Disseminated MAC characteristically involves 
multiple nodes, spleen, liver, bone marrow, and blood, and is an 
opportunistic infection almost uniquely associated with patients with 
advanced AIDS with CD4 lymphocyte count < 50 cells/mm(3) and/or high plasma 
HIV RNA > 100,000 copies/mL. In HIV negative patients without 
immunosuppression, pulmonary MAC occurs in smokers, cystic fibrosis 
patients, and elderly women with nodular bronchiectasis. We report a case of 
a 60-year-old African American HIV-negative man with a past medical history 
of quadriplegia secondary to C3-C4 spinal cord injury, status post 
tracheostomy and PEG tube placement, ventilatordependent chronic respiratory 
failure, presenting to the emergency department for dislodged PEG tube. At 
admission, the patient was hypertensive with blood pressure of 163/123 mm of 
Hg and was given one dose of labetalol. Subsequently, he became hypotensive 
with blood pressure of 60/30 mm of Hg and was treated with IV fluids and 
pressors. The patient had leukocytosis (31.3 TH/cu mm) with 90% neutrophils, 
mild anemia (Hb 9.3 g/dL), and thrombocytopenia (77 TH/mm(3)). Routine 
peripheral blood cultures were positive for acid-fast bacilli 6 days after 
inoculation. MAC was identified using DNA probe 3 weeks later. The patient 
was started on broadspectrum antibiotics (vancomycin and zosyn). The patient 
continued to have worsening hypotension despite increasing doses of pressors 
and ultimately died on the fifth day of admission despite aggressive life 
support. Disseminated MAC is a potentially fatal infection and the most 
common cause of death in AIDS patients. This case highlights the unusual 
presentation of MAC in an immunocompetent patient with multiple 
comorbidities. It is important to screen for MAC irrespective of HIV status 
so that prompt treatment of this potentially lethal infection can be 
initiated.
EMTREE DRUG INDEX TERMS
  antibiotic agent; antihypertensive agent; CD4 antigen; DNA; hypertensive factor; labetalol; piperacillin plus tazobactam; RNA; vancomycin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; blood culture; human; Mycobacterium avium complex; pathology; patient; sepsis; society; 
EMTREE MEDICAL INDEX TERMS
  acid fast bacterium; acquired immune deficiency syndrome; African American; aged; AIDS patient; anemia; blood; blood pressure; bone marrow; bronchiectasis; cause of death; chronic respiratory failure; cystic fibrosis; DNA probe; emergency ward; female; Human immunodeficiency virus; hypotension; immunosuppressive treatment; infection; inoculation; leukocytosis; liquid; liver; lymphocyte count; male; medical history; Mycobacterium avium; Mycobacterium intracellulare; neutrophil; opportunistic infection; plasma; quadriplegia; smoking; spinal cord injury; spleen; thrombocytopenia; tracheostomy; tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72167196
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00029173&id=doi:&atitle=Mycobacterium+avium+complex+%28MAC%29+sepsis+in+an+immunocompetent+patient+isolated+from+routine+blood+culture&stitle=Am.+J.+Clin.+Pathol.&title=American+Journal+of+Clinical+Pathology&volume=144&issue=&spage=A229&epage=&aulast=Khan&aufirst=Farhan&auinit=F.&aufull=Khan+F.&coden=&isbn=&pages=A229-&date=2015&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 318
TITLE
  The effects of landiolol on pial microvessels during normal state period in 
rabbits
AUTHOR NAMES
  Hishiyama S.; Nobumasa A.; Ishiyama T.; Matsukawa T.
AUTHOR ADDRESSES
  (Hishiyama S.) Anesthesiology, Yamanashi Prefectural Hospital, Kofu, 
Yamanashi, Japan.
(Nobumasa A.; Ishiyama T.; Matsukawa T.) Anesthesiology, University of 
Yamanashi, Chuo, Yamanashi, Japan.
CORRESPONDENCE ADDRESS
  S. Hishiyama, Anesthesiology, Yamanashi Prefectural Hospital, Kofu, 
Yamanashi, Japan.
FULL RECORD ENTRY DATE
  2016-05-31
SOURCE
  Journal of Neurosurgical Anesthesiology (2015) 27:4 (367). Date of 
Publication: October 2015
VOLUME
  27
ISSUE
  4
FIRST PAGE
  367
DATE OF PUBLICATION
  October 2015
CONFERENCE NAME
  19th Annual Meeting of the Japanese Society of Neuroanesthesia and Critical 
Care
CONFERENCE LOCATION
  Gifu, Japan
CONFERENCE DATE
  2015-04-10 to 2015-04-11
ISSN
  1537-1921
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: Landiolol is ultra-short-acting b1-selective blocker and widely 
used for perioperative tachyarrhythmia. Landiolol has nerve protective 
functions for spinal cord and brain ischemia in rats. However vascular 
effect of landiolol has not been investigated. The aim of this study was to 
evaluate the direct effect of landiolol on cerebral pial arterial diameter 
change in the normal state rabbits. Methods: Experiments were performed on 
Japanese white rabbits weighing 2.8-3.6 kg. After obtaining IV access in an 
ear vein, the animals were anesthetized with pentobarbital sodium (20mg. 
kg(-1) IV and 5mg kg(-1) . h(-1) CIV). The animals were tracheostomized and 
their lungs were mechanically ventilated. A closed cranial window was 
implanted over the cerebral hemisphere. Topical application of 4 increasing 
concentrations of landiolol (10(-10), 10(-8), 10(-6), and 10(-4) mol . 
L(-1)) dissolved in artificial cerebrospinal fluid was superfused for 5 
minutes each. We measured the diameters of pial vessels before (control) and 
5 minutes after the application of each concentration. The window was then 
flushed with a CSF for 30 minutes before the next concentration was 
administered. Values are represented as mean ± SD. Cerebral pial vascular 
changes in diameter from the control were examined via paired ttest. A P 
value less than 0.05 was considered statistically significant. Results: 
There were no significant differences in hemodynamic and physiologic 
variables during the experimental period. When landiolol was superfused at 
10-10 mol . L(-1), pial arteriolar diameter changed by 14.3±20.5%. While 
landiolol at 10-6, 10-4 mol . L(-1) also dilated pial arterioles, 10-10 mol 
. L(-1) significantly dilated pial arterioles. Conclusions: Landiolol 
dilated normal pial arterioles in rabbits. Landiolol may be a potent 
cerebrovascular dilator. Cerebral vasodilation caused by landiolol may 
partly contribute to nerve protection.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  landiolol; 
EMTREE DRUG INDEX TERMS
  pentobarbital; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; human; intensive care; Japanese (people); Leporidae; microvasculature; society; 
EMTREE MEDICAL INDEX TERMS
  arteriole; artery diameter; brain ischemia; cerebrospinal fluid; ear; hemisphere; Japanese White (rabbit); lung; nerve; protection; rat; spinal cord; statistical significance; tachycardia; topical drug administration; vasodilatation; vein; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72287281
DOI
  10.1097/ANA.0000000000000208
FULL TEXT LINK
  http://dx.doi.org/10.1097/ANA.0000000000000208
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15371921&id=doi:10.1097%2FANA.0000000000000208&atitle=The+effects+of+landiolol+on+pial+microvessels+during+normal+state+period+in+rabbits&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=27&issue=4&spage=367&epage=&aulast=Hishiyama&aufirst=Sohei&auinit=S.&aufull=Hishiyama+S.&coden=&isbn=&pages=367-&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 319
TITLE
  Open repair of ruptured descending thoracic and thoracoabdominal aortic 
aneurysms Read at the 95th Annual Meeting of the American Association for 
Thoracic Surgery, Seattle, Washington, April 25-29, 2015.
AUTHOR NAMES
  Gaudino M.; Lau C.; Munjal M.; Girardi L.N.
AUTHOR ADDRESSES
  (Gaudino M.; Lau C.; Munjal M.; Girardi L.N., lngirard@med.cornell.edu) 
Department of Cardiothoracic Surgery, Weill Cornell Medical College, 525 E 
68th St, Ste M404, New York, United States.
(Gaudino M.) Department of Cardiovascular Sciences, Catholic University, 
Rome, Italy.
CORRESPONDENCE ADDRESS
  L.N. Girardi, Department of Cardiothoracic Surgery, Weill Cornell Medical 
College, 525 E 68th St, Ste M404, New York, United States.
AiP/IP ENTRY DATE
  2015-08-03
FULL RECORD ENTRY DATE
  2015-10-12
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2015) 150:4 (814-821). Date 
of Publication: 1 Oct 2015
VOLUME
  150
ISSUE
  4
FIRST PAGE
  814
LAST PAGE
  821
DATE OF PUBLICATION
  1 Oct 2015
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Objective To evaluate the results of the open repair of ruptured thoracic 
and thoracoabdominal aortic aneurysms. Methods From January 1997, a total of 
100 consecutive open repairs of ruptured thoracic or thoracoabdominal aortic 
aneurysms were performed (43 thoracic and 57 thoracoabdominal). These 
patients were compared with contemporary cases that underwent repair of 
corresponding intact aneurysms. Propensity matching analysis was used to 
neutralize the differences in baseline characteristics. Results Patients 
with ruptured aneurysm had a significantly worse baseline clinical profile. 
The surgical strategy adopted was similar in intact and ruptured aneurysms, 
with the exception of lower use of spinal drainage, intercostal 
reimplantation, and associated procedures in those with rupture (P <.001 for 
all comparisons). In the unmatched population, in-hospital mortality was 14% 
in the rupture group, and 4.2% in the intact group (P =.01). The incidence 
of postoperative myocardial infarction, need for tracheostomy, and need for 
dialysis was 3%, 19%, and 11% in the rupture, and 0.8%, 5.7%, and 4.2% in 
the intact series (P <.01 for all variables). Five-year survival was 47.5% 
for the rupture, and 59.5% for the intact series (P <.001). In the matched 
population, no differences in postoperative and long-term outcome were found 
between the rupture and intact cases. Logistic regression analysis showed 
that female gender, urgent/emergent operation, and preoperative 
hemodialysis, but not ruptured aneurysm, were predictive of in-hospital 
major adverse events. Conclusions Open repair of ruptured thoracic and 
thoracoabdominal aortic aneurysms can be performed with a gratifying rate of 
success. For patients with similar preoperative comorbidities, postoperative 
survival is not affected by the presence of a ruptured aneurysm.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm rupture (surgery); ruptured descending thoracic aortic aneurysm (surgery); thoracic aorta aneurysm (surgery); thoracoabdominal aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; artery diameter; cardiopulmonary bypass; cerebrovascular accident (complication); conference paper; controlled study; deep hypothermic circulatory arrest; endovascular aneurysm repair; female; follow up; heart arrhythmia (complication); heart infarction (complication); human; kidney failure (complication); long term survival; major clinical study; male; multiple organ failure (complication); postoperative complication (complication); postoperative hemorrhage (complication); priority journal; recurrent laryngeal nerve palsy (complication); reimplantation; sepsis (complication); spinal cord injury (complication); surgical mortality; thoracotomy; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015227149
MEDLINE PMID
  26227985 (http://www.ncbi.nlm.nih.gov/pubmed/26227985)
PUI
  L605370221
DOI
  10.1016/j.jtcvs.2015.06.077
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2015.06.077
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2015.06.077&atitle=Open+repair+of+ruptured+descending+thoracic+and+thoracoabdominal+aortic+aneurysms+Read+at+the+95th+Annual+Meeting+of+the+American+Association+for+Thoracic+Surgery%2C+Seattle%2C+Washington%2C+April+25-29%2C+2015.&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=150&issue=4&spage=814&epage=821&aulast=Gaudino&aufirst=Mario&auinit=M.&aufull=Gaudino+M.&coden=JTCSA&isbn=&pages=814-821&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 320
TITLE
  American Spinal Injury Association Impairment Scale Predicts the Need for 
Tracheostomy after Cervical Spinal Cord Injury
AUTHOR NAMES
  Childs B.R.; Moore T.A.; Como J.J.; Vallier H.A.
AUTHOR ADDRESSES
  (Childs B.R.; Moore T.A.; Como J.J.; Vallier H.A., hvallier@metrohealth.org) 
MetroHealth Medical Center, Cleveland, United States.
(Childs B.R.; Moore T.A.; Como J.J.; Vallier H.A., hvallier@metrohealth.org) 
Department of Orthopaedic Surgery, Case Western Reserve University, 2500 
MetroHealth Dr, Cleveland, United States.
CORRESPONDENCE ADDRESS
  H.A. Vallier, Department of Orthopaedic Surgery, Case Western Reserve 
University, 2500 MetroHealth Dr, Cleveland, United States. Email: 
hvallier@metrohealth.org
AiP/IP ENTRY DATE
  2015-09-11
FULL RECORD ENTRY DATE
  2015-09-15
SOURCE
  Spine (2015) 40:18 (1407-1413). Date of Publication: 15 Sep 2015
VOLUME
  40
ISSUE
  18
FIRST PAGE
  1407
LAST PAGE
  1413
DATE OF PUBLICATION
  15 Sep 2015
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Study design. Retrospective review. Objective. The objective of this study 
was to evaluate the ability of the American Spinal Injury Association (ASIA) 
Impairment Scale and neurological level of injury to predict the need for 
mechanical ventilation as well as tracheostomy. Summary of Background Data. 
High-level cervical spinal cord injuries, high Injury Severity Score, and 
low Glasgow Coma Scale have been shown to predict tracheostomy. Methods. A 
total of 383 patients with fractures, dislocations, or ligamentous injury of 
the cervical spine were included in the study. Charts were reviewed to 
determine demographics, Injury Severity Score, Glasgow Coma Scale, presence 
and severity of chest injuries, length of hospital stay, intensive care unit 
stay, mechanical ventilation time, and mortality. Results. Fifty-nine 
patients (15.4%) underwent tracheostomy. An ASIA Impairment Scale of A had a 
specificity of 98.8% and sensitivity of 32.2% for predicting the need for 
tracheostomy. This yielded a 1.2% false-positive rate. The ASIA Impairment 
Scale remained the most significant predictor after regression for Injury 
Severity Score, Glasgow Coma Scale, and Chest Abbreviated Injury Scale. 
Neurological level of injury was not a significant predictor of 
tracheostomy. Conclusion. An ASIA Impairment Scale of A at any level of 
injury is a specific predictor of the need for tracheostomy with a low 
false-positive rate. Given the relatively low risk of early tracheostomy and 
the potential benefits, an ASIA Impairment Scale of A would be a sensible 
early criterion to determine the need for tracheostomy. Level of Evidence: 
3.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American Spinal Injury Association impairment scale; cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; cervical spine dislocation; cervical spine fracture; cervical spine injury; Chest Abbreviated Injury Scale; falling; false positive result; female; Glasgow coma scale; hospitalization; human; injury scale; injury severity; major clinical study; male; middle aged; mortality; priority journal; retrospective study; review; sensitivity and specificity; skull fracture; subarachnoid hemorrhage; subdural hematoma; thorax injury; traffic accident; traumatic brain injury; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015357075
MEDLINE PMID
  26426711 (http://www.ncbi.nlm.nih.gov/pubmed/26426711)
PUI
  L605918121
DOI
  10.1097/BRS.0000000000001008
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000001008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000001008&atitle=American+Spinal+Injury+Association+Impairment+Scale+Predicts+the+Need+for+Tracheostomy+after+Cervical+Spinal+Cord+Injury&stitle=Spine&title=Spine&volume=40&issue=18&spage=1407&epage=1413&aulast=Childs&aufirst=Benjamin+R.&auinit=B.R.&aufull=Childs+B.R.&coden=SPIND&isbn=&pages=1407-1413&date=2015&auinit1=B&auinitm=R
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 321
TITLE
  Developing a comprehensive assessment system: A case report
AUTHOR NAMES
  Sliwa J.A.; Moore J.
AUTHOR ADDRESSES
  (Moore J.)
(Sliwa J.A.) Rehabilitation Institute of Chicago, Chicago, United States.
CORRESPONDENCE ADDRESS
  J.A. Sliwa, Rehabilitation Institute of Chicago, Chicago, United States.
FULL RECORD ENTRY DATE
  2015-11-20
SOURCE
  PM and R (2015) 7:9 SUPPL. 1 (S152). Date of Publication: September 2015
VOLUME
  7
ISSUE
  9
FIRST PAGE
  S152
DATE OF PUBLICATION
  September 2015
CONFERENCE NAME
  2015 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  Boston, MA, United States
CONFERENCE DATE
  2015-10-01 to 2015-10-04
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: A 23-year-old man admitted for rehabilitation following 
high speed motor vehicle accident resulting in C3eC4 fracture and C4 ASIA B 
spinal cord injury. The patient required a posterior spinal reduction and 
fixation with HALO placement, prolonged ventilation with tracheostomy and 
feeding tube placement. During rehabilitation the patient participated fully 
and tolerated therapy well. At the time of discharge the patient had been 
decannulated, his spasticity was controlled with medication, feeding tube 
was removed, bowels were regulated and an indwelling catheter was used for 
bladder management. The patient demonstrated improved breath support, cough 
strength and vocal intensity. He was independent in power wheelchair 
mobility with sip and puff controls and the use of a mouthstick for iPad use 
and TV controls. The caregiver (patient's father) was independent in 
providing and the patient independent in directing all self care, transfers, 
skin care, pressure reliefs, positioning and stretching. The patient was 
discharged home with his father. Despite attainment of rehabilitation goals 
and safe discharge home the total FIM gain was only 4 points. Setting: 
Inpatient rehabilitation facility. Results or Clinical Course: FIM does not 
capture progress made by this patient and for many other patients during 
rehabilitation. Discussion: To address this issue we are developing an 
assessment tool that can reliably capture and reflect progress in a 
comprehensive manner. Multi disciplinary expert clinician panels first 
identified 60 new clinically relevant domains and 40 assessment tools 
suitable for patients with stroke, TBI, SCI, neurologic and general 
rehabilitation needs. We are now pilot testing these tools on inpatient 
units for clinical relevance and operational feasibility. Based on pilot 
data a final battery of assessment tools will be fully implemented. We will 
then use item response theory (IRT) models to reduce assessment burden 
without decreasing measurement precision. Conclusion: This project will 
identify and evaluate a set of standardized assessment tools that minimizes 
clinician and patient assessment burden while assessing areas of function in 
which patient progress is not adequately documented.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; case report; human; physical medicine; rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; bladder; breathing; caregiver; cerebrovascular accident; coughing; disease course; drug therapy; father; feeding apparatus; fracture; hospital patient; indwelling catheter; intestine; male; measurement precision; model; patient; patient assessment; self care; skin care; spasticity; spinal cord injury; stretching; therapy; tracheostomy; traffic accident; velocity; wheelchair; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72072611
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Developing+a+comprehensive+assessment+system%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=7&issue=9&spage=S152&epage=&aulast=Moore&aufirst=Jennifer&auinit=J.&aufull=Moore+J.&coden=&isbn=&pages=S152-&date=2015&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 322
TITLE
  Development of a hybrid tracheostomy management skills workshop for physical 
medicine and rehabilitation residents: A case study
AUTHOR NAMES
  Pineda C.
AUTHOR ADDRESSES
  (Pineda C.) MedStar National Rehabilitation Hospital, Washington, United 
States.
CORRESPONDENCE ADDRESS
  C. Pineda, MedStar National Rehabilitation Hospital, Washington, United 
States.
FULL RECORD ENTRY DATE
  2015-11-20
SOURCE
  PM and R (2015) 7:9 SUPPL. 1 (S153-S154). Date of Publication: September 
2015
VOLUME
  7
ISSUE
  9
FIRST PAGE
  S153
LAST PAGE
  S154
DATE OF PUBLICATION
  September 2015
CONFERENCE NAME
  2015 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  Boston, MA, United States
CONFERENCE DATE
  2015-10-01 to 2015-10-04
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: To describe the development of a hybrid formative 
instruction and evaluation of tracheostomy management skills focused on 
responding to accidental decannulation in a supervised simulated setting. 
Program Description: 18 PM&R Residents participated in a hybrid formative 
workshop composed of a didactic session and hands-on simulation. The 
didactic session led by an ENT specialist focused on: 1) anatomy and 
physiology of the upper respiratory tract; 2) tracheostomy tube types; 3) 
management of accidental decannulation; 4) complications of tracheostomy 
re-insertion; 5) post-tracheostomy reinsertion assessment ; 6) documentation 
of hand-off care and 7) tracheostomy practice guidelines per hospital 
standards. The simulation session focused on: 1) rapid assessment and rescue 
of a patient with a dislodged tracheostomy using a mannequin simulator and 
2) basic airway skills training. A checklist was used to assess 
competencies. Setting: Free-standing academic rehabilitation hospital. 
Results or Clinical Course: Instructional techniques were experiential and 
learner-centered. Instructors assessed resident performance through return 
demonstrations structured to apply competencies. Participants received 
additional instruction and practice as needed. Resident post-activity 
evaluations using a 5-point Likert scale: overall resident evaluation 
(62%=excellent, 37%=good); a new skill/ patient management approach was 
learned (50%=strongly agree; 50%=agree). Discussion: Tracheostomy management 
is an essential skill for the practicing physiatrist especially those 
involved in the care of patients with brain injury, spinal cord injury and 
stroke. PM&R residents are likely to encounter clinical situations that 
require re-insertion of tracheostomy tubes in the acute rehabilitation 
setting. Conclusion: Accidental tracheostomy decannulation is a condition 
that may be encountered in an acute rehabilitation setting. It is imperative 
that rehabilitation care providers, such as PM&R residents, who care for 
patients with tracheostomies be knowledgeable on how to assess and manage 
this medical emergency to ensure patient safety.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; case study; physical medicine; rehabilitation; skill; tracheostomy; workshop; 
EMTREE MEDICAL INDEX TERMS
  airway; brain injury; cerebrovascular accident; checklist; disease course; documentation; emergency; hospital; human; Likert scale; medical specialist; otorhinolaryngology; patient; patient care; patient safety; physiology; practice guideline; rehabilitation care; simulation; simulator; spinal cord injury; tracheostomy tube; upper respiratory tract; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72072616
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Development+of+a+hybrid+tracheostomy+management+skills+workshop+for+physical+medicine+and+rehabilitation+residents%3A+A+case+study&stitle=PM+R&title=PM+and+R&volume=7&issue=9&spage=S153&epage=S154&aulast=Pineda&aufirst=Cynthia&auinit=C.&aufull=Pineda+C.&coden=&isbn=&pages=S153-S154&date=2015&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 323
TITLE
  Airway complications in traumatic lower cervical spinal cord injury: A 
retrospective study
AUTHOR NAMES
  Liebscher T.; Niedeggen A.; Estel B.; Seidl R.O.
AUTHOR ADDRESSES
  (Liebscher T., thomas.liebscher@ukb.de; Niedeggen A.) Treatment Centre for 
Spinal Cord Injuries, Trauma Hospital Berlin, Warener Straße 7, , Germany.
(Estel B.) Clinic for Anesthesiology and Intensive Medicine, Trauma 
Hospital, Germany.
(Seidl R.O.) Department of Otolaryngology, Trauma Hospital, Germany.
CORRESPONDENCE ADDRESS
  T. Liebscher, Treatment Centre for Spinal Cord Injuries, Trauma Hospital 
Berlin, Warener Straße 7, , Germany. Email: thomas.liebscher@ukb.de
FULL RECORD ENTRY DATE
  2015-09-15
SOURCE
  Journal of Spinal Cord Medicine (2015) 38:5 (607-614). Date of Publication: 
1 Sep 2015
VOLUME
  38
ISSUE
  5
FIRST PAGE
  607
LAST PAGE
  614
DATE OF PUBLICATION
  1 Sep 2015
ISSN
  2045-7723 (electronic)
  1079-0268
BOOK PUBLISHER
  Maney Publishing, maney@maney.co.uk
ABSTRACT
  Objective: To investigate risk factors for pneumonia in patients with 
traumatic lower cervical spinal cord injury. Design: Observational study, 
retrospective study. Setting: Spinal cord unit in a maximum care hospital. 
Methods: Thirty-seven patients with acute isolated traumatic spinal cord 
injury at levels C4-C8 and complete motor function injury (AIS A, B) treated 
from 2004 to 2010 met the criteria for inclusion in our retrospective 
analysis. The following parameters were considered: ventilation-specific 
parameters, re-intubation, creation of a tracheostomy, pneumonia, antibiotic 
treatment, and length of intensive care unit (ICU) stay and total 
hospitalization. Results: Among the patients, 81% had primary invasive 
ventilation. In 78% of cases a tracheostomy was created; 3% of these cases 
were discharged with invasive ventilation and 28% with a tracheostomy 
without ventilation. Pneumonia according to Centers for Disease Control 
criteria occurred in 51% of cases within 21 ± 32 days of injury, and in 3% 
at a later date. The number of pre-existing conditions was significantly 
associated with pneumonia. Length of ICU stay was 25 ± 34 days, and average 
total hospital duration was 230 ± 144 days. Significant factors affecting 
the duration of ventilation were the number of pre-existing conditions and 
tetraplegia-specific complications. Conclusions: Our results confirm that 
patients with traumatic lower cervical spinal cord injuries defined by 
lesion level and AIS constitute a homogeneous group. This group is 
characterized by a high rate of pneumonia during the first 4 weeks after 
injury. The number of pre-existing general conditions and spinal 
injury-specific comorbidities are the only risk factors identified for the 
development of pneumonia and/or duration of ventilation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; pneumonia (complication); respiratory tract disease (complication); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; antibiotic therapy; article; artificial ventilation; clinical article; comorbidity; controlled study; extubation; female; hospital discharge; hospital subdivisions and components; hospitalization; human; intensive care unit; length of stay; male; motor dysfunction; quadriplegia; retrospective study; risk factor; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015362528
MEDLINE PMID
  25117865 (http://www.ncbi.nlm.nih.gov/pubmed/25117865)
PUI
  L605945483
DOI
  10.1179/2045772314Y.0000000254
FULL TEXT LINK
  http://dx.doi.org/10.1179/2045772314Y.0000000254
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20457723&id=doi:10.1179%2F2045772314Y.0000000254&atitle=Airway+complications+in+traumatic+lower+cervical+spinal+cord+injury%3A+A+retrospective+study&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=38&issue=5&spage=607&epage=614&aulast=Liebscher&aufirst=Thomas&auinit=T.&aufull=Liebscher+T.&coden=JSCMC&isbn=&pages=607-614&date=2015&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 324
TITLE
  A clinical study of laryngotracheal separation in spinal muscular atrophy 
type i patients
AUTHOR NAMES
  Fujioka T.; Nakano K.; Maniwa S.
AUTHOR ADDRESSES
  (Fujioka T., fujioka-t@shikoku-ctr-hsp.jp; Nakano K.; Maniwa S.) Division of 
Pediatrics, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan.
AiP/IP ENTRY DATE
  2015-10-06
FULL RECORD ENTRY DATE
  2015-10-12
SOURCE
  No To Hattatsu (2015) 47:5 (360-362). Date of Publication: 1 Sep 2015
VOLUME
  47
ISSUE
  5
FIRST PAGE
  360
LAST PAGE
  362
DATE OF PUBLICATION
  1 Sep 2015
ISSN
  0029-0831
BOOK PUBLISHER
  Japanese Society of Child Neurology
ABSTRACT
  Artificial respiration by tracheostomy is necessary for long-term survival 
in spinal muscular atrophy (SMA) Type I patients. There are two types of 
tracheostomy: i) simple tracheostomy and ii) tracheostomy plus aspiration 
prevention surgery, including laryngotracheal separation. We experienced 
three cases of SMA type I patients that had good outcomes after undergoing 
laryngotracheal separation. The patients' ages at onset were 14 days, two 
months and one and a half months. Laryngotracheal separation was performed 
at five months, seven months, and 15 years and five months respectively, and 
the times from diagnosis to surgery were a month, three months and 15 years. 
The aspiration pneumonia disappeared in all three cases. This study suggests 
that laryngotracheal separation is an effective surgery to prevent 
aspiration in SMA type I cases, and also contributes to the improved quality 
of life of patients and their families.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  laryngotracheal separation; spinal muscular atrophy (surgery); surgical technique; trachea surgery; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; aspiration pneumonia; human; long term survival; outcome assessment; quality of life; tracheostomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2015412011
MEDLINE PMID
  26502653 (http://www.ncbi.nlm.nih.gov/pubmed/26502653)
PUI
  L606204187
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00290831&id=doi:&atitle=A+clinical+study+of+laryngotracheal+separation+in+spinal+muscular+atrophy+type+i+patients&stitle=No+To+Hattatsu&title=No+To+Hattatsu&volume=47&issue=5&spage=360&epage=362&aulast=Fujioka&aufirst=Tomohito&auinit=T.&aufull=Fujioka+T.&coden=NTHAA&isbn=&pages=360-362&date=2015&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 325
TITLE
  Cough augmentation techniques for extubation and weaning critically ill 
patients from mechanical ventilation
AUTHOR NAMES
  Rose L.; Adhikari N.K.J.; Leasa D.; Fergusson D.A.; Mckim D.
AUTHOR ADDRESSES
  (Rose L., louise.rose@utoronto.ca) University of Toronto, Lawrence S. 
Bloomberg Faculty of Nursing, 155 College St, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.J.) University of Toronto, 
Interdepartmental Division of Critical Care, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca) Toronto East General Hospital, Provincial 
Weaning Centre of Excellence, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca; Adhikari N.K.J.) Sunnybrook Health 
Sciences Centre, Department of Critical Care Medicine and Sunnybrook 
Research Institute, Toronto, Canada.
(Leasa D.) London Health Sciences Centre, Critical Care, 339 Windermere 
Road, London, Canada.
(Fergusson D.A.) Ottawa Hospital Research Institute, Clinical Epidemiology 
Program, 501 Smyth Road, Ottawa, Canada.
(Mckim D.) Ottawa Hospital, Respiratory Rehabilitation and Sleep Centre, 501 
Smyth Rd, Ottawa, Canada.
CORRESPONDENCE ADDRESS
  L. Rose, University of Toronto, Lawrence S. Bloomberg Faculty of Nursing, 
155 College St, Toronto, Canada. Email: louise.rose@utoronto.ca
AiP/IP ENTRY DATE
  2018-02-15
FULL RECORD ENTRY DATE
  2018-02-27
SOURCE
  Cochrane Database of Systematic Reviews (2015) 2015:8 Article Number: 
CD011833. Date of Publication: 10 Aug 2015
VOLUME
  2015
ISSUE
  8
DATE OF PUBLICATION
  10 Aug 2015
ISSN
  1469-493X (electronic)
BOOK PUBLISHER
  John Wiley and Sons Ltd, Southern Gate, Chichester, West Sussex, United 
Kingdom. vgorayska@wiley.com
ABSTRACT
  This is the protocol for a review and there is no abstract. The objectives 
are as follows: The primary objective of this systematic review is to 
determine extubation success rates of cough augmentation techniques compared 
to no cough augmentation for critically ill adult and paediatric patients 
with acute respiratory failure admitted to a high intensity care setting 
capable of providing care to patients requiring invasive mechanical 
ventilation (such as ICU, specialized weaning centre, respiratory 
intermediate care unit, or high dependency unit). Secondary objectives will 
be to determine the following. The effect of cough augmentation techniques 
on reintubation; weaning success; duration of mechanical ventilation; 
duration of weaning; high intensity care setting and hospital length of 
stay; high intensity care setting and hospital mortality, as well as 
mortality after hospital discharge; pneumonia; tracheostomy; and 
tracheostomy decannulation rates. The harms associated with use of cough 
augmentation techniques when applied via an artificial airway (or 
non-invasive mask once extubated/decannulated) such as haemodynamic 
compromise, arrhythmias, pneumothorax, haemoptysis, and mucus plugging 
requiring change of the endotracheal or tracheostomy tube. The type of 
patients (such as those with neuromuscular disorders or weakness and spinal 
cord injury) for whom these techniques are most likely to be efficacious.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; coughing; critically ill patient; extubation; weaning; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; article; endotracheal tube; heart arrhythmia; hemodynamics; hemoptysis; hospital discharge; hospital mortality; hospitalization; human; length of stay; patient care; pneumonia; pneumothorax; priority journal; risk assessment; systematic review; tracheostomy; tracheostomy tube; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20180098407
PUI
  L620549252
DOI
  10.1002/14651858.CD011833
FULL TEXT LINK
  http://dx.doi.org/10.1002/14651858.CD011833
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1469493X&id=doi:10.1002%2F14651858.CD011833&atitle=Cough+augmentation+techniques+for+extubation+and+weaning+critically+ill+patients+from+mechanical+ventilation&stitle=Cochrane+Database+Syst.+Rev.&title=Cochrane+Database+of+Systematic+Reviews&volume=2015&issue=8&spage=&epage=&aulast=Rose&aufirst=Louise&auinit=L.&aufull=Rose+L.&coden=&isbn=&pages=-&date=2015&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 326
TITLE
  Strategy by stages for preventing respiratory complications of acute 
cervical spinal cord injury
AUTHOR NAMES
  Lai B.; Wu J.; Gao Z.; Lian W.
AUTHOR ADDRESSES
  (Lai B.; Wu J.; Gao Z.; Lian W.)
FULL RECORD ENTRY DATE
  2016-01-08
SOURCE
  Zhongguo gu shang = China journal of orthopaedics and traumatology (2015) 
28:8 (690-694). Date of Publication: 1 Aug 2015
VOLUME
  28
ISSUE
  8
FIRST PAGE
  690
LAST PAGE
  694
DATE OF PUBLICATION
  1 Aug 2015
ISSN
  1003-0034
ABSTRACT
  OBJECTIVE: To investigate clinical effects of strategy by stages for 
preventing respiratory complications of patients with acute cervical spinal 
cord injury (ACSCI).METHODS: From September 2009 to May 2013,the clinical 
data of 91 patients with ACSCI underwent surgery were retrospectively 
analyzed. Among the patients, 42 patients were divided into in-stages group, 
including 30 males and 12 females with an average age of 50 years old 
(ranged 28 to 76) which were treated with strategy by stages for preventing 
respiratory complications; others 49 patients which were not treated with 
the strategy regarded as control group, including 38 males and 11 females 
with an average age of 47 years old (ranged 30 to 77). All of them had 
definite history of trauma, and were admitted to orthopaedics within 48 h 
after trauma. In in-stages group, respiratory muscle strength training, 
high-dose ambroxol using and other treatment were performed to prevent 
respiratory complilcations according to preoperative, intraoperative and 
postoperative stage. While in control group, there were no systematic and 
effective measures utilized. Chi-square test was used to evaluate the 
difference for respiratory complications rate, the rate of tracheostomy or 
intubation and mortality caused by the respiratory complications between two 
groups.RESULTS: Ten patients developed with respiratory complications in 
in-stages group (7 patients with pneumonia, 1 with atelectasis and 2 with 
respiratory failure), among which 3 patients underwent tracheostomy or 
intubation. In control group, 24 patients developed with respiratory 
complilcations (15 with pneumonia,3 with atelectasis and 6 with respiratory 
failure), among which 11 patients underwent tracheostomy or intubation. 
There was significant difference between two groups (χ2 = 6.12, 4.07; P = 
0.013, 0.044). Five patients died because of respiratory complications, one 
case were in in-stages group and 4 in control group. There was significant 
difference between two groups (χ2 = l.39, P = 0.238).CONCLUSION: The 
strategy by stages is an effective method for preventing respiratory 
complications of ACSCI and can reduce the respiratory complications rate and 
improve the prognosis of respiratory complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injuries; injuries; 
EMTREE MEDICAL INDEX TERMS
  acute disease; adult; aged; atelectasis (prevention, prevention); cervical spinal cord; complication; female; human; male; middle aged; pneumonia (prevention, prevention); respiratory failure (prevention, prevention); retrospective study; spinal cord injury; tracheostomy; 
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  26502516 (http://www.ncbi.nlm.nih.gov/pubmed/26502516)
PUI
  L607543308
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10030034&id=doi:&atitle=Strategy+by+stages+for+preventing+respiratory+complications+of+acute+cervical+spinal+cord+injury&stitle=Zhongguo+Gu+Shang&title=Zhongguo+gu+shang+%3D+China+journal+of+orthopaedics+and+traumatology&volume=28&issue=8&spage=690&epage=694&aulast=Lai&aufirst=Bi-hua&auinit=B.&aufull=Lai+B.&coden=&isbn=&pages=690-694&date=2015&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2016 Medline is the source for the citation and abstract of this 
record.

RECORD 327
TITLE
  Oesophageal perforation following anterior cervical spine fixation: 
Management and results
AUTHOR NAMES
  Daddi N.; Perrone O.; Lugaresi M.; Borghesi I.; Belloni G.P.; Uneddu M.; Mattioli S.
AUTHOR ADDRESSES
  (Daddi N.) Medical and Surgical Sciences, University of Bologna, Bologna, 
Italy.
(Perrone O.; Lugaresi M.; Mattioli S.) Division of Thoracic Surgery GVM Care 
and Research, University of Bologna, Bologna, Italy.
(Borghesi I.) Division of Neurosurgery, GVM Care and Research, Cotignola, 
Italy.
(Belloni G.P.; Uneddu M.) Department of Rehabilitation, Montecatone 
Rehabilitation Institute, Imola, Italy.
CORRESPONDENCE ADDRESS
  N. Daddi, Medical and Surgical Sciences, University of Bologna, Bologna, 
Italy.
FULL RECORD ENTRY DATE
  2015-09-08
SOURCE
  Interactive Cardiovascular and Thoracic Surgery (2015) 21 SUPPL. 1. Date of 
Publication: August 2015
VOLUME
  21
DATE OF PUBLICATION
  August 2015
CONFERENCE NAME
  23rd European Conference on General Thoracic Surgery
CONFERENCE LOCATION
  Lisbon, Portugal
CONFERENCE DATE
  2015-05-31 to 2015-06-03
ISSN
  1569-9293
BOOK PUBLISHER
  Oxford University Press
ABSTRACT
  Objectives: Delayed pharyngooesophageal perforation is a rare and fairly 
unknown complication of anterior cervical spine fixation (ACDF). A survey of 
the Cervical Spine Research Society reported an overall perforation rate of 
0.25%. The optimal treatment remains debatable. A retrospective review of 
our personal case series was conducted. Methods: Thirteen cases of 
oesophageal perforation related to ACDF procedure were observed in the 
period between 2004 and 2014. ACDF had been carried out at C4-C7 level. 
Common symptoms were facial, neck swelling or persistent pain, dysphagia 
hyperpyrexia, clinical evidence of abscess or cutaneous salivary fistula. 
The mean delay in symptoms acme was 24 days (range 12 days-9 years). 
Computed tomography scan with or without ± gastrografin was the preferred 
preoperative strategy. Test to investigate the neck soft tissues and the 
fixation devices status. Results: All patients had tracheostomy. The primary 
treatment was lateral neck drainage and percutaneous gastrostomy and 
broad-spectrum antibiotics. Three patients with minor infection and small 
fistulas not adjacent to fixation devices were managed conservatively. Ten 
patients (in 2 cases perforation was intraoperative, in 8 cases it was due 
to screw decubitus) were surgically managed: 1) adequate preoperative spine 
stabilization, 2) lateral cervicotomy, 3) wide pharynx and proximal 
oesophagus mobilization, 4) clearing of the mucosal tear margins, 4) 
double-layer suture of the fistula, 5) muscular flap reinforcement (with 
sternocleidomastoid muscle in 8 cases, with pectoralis major muscle in 2. 
Mean length of stay was 24.1 days (range 10-61). No operative mortality 
occurred. Major comorbidities were chronic respiratory failure (n = 7), 
infective status (n = 6) and arterial hypertension (n = 2). Conclusions: 
Neck drainage to protect tracheostomy and treat infection are mandatory. 
Enteral nutrition promotes a favourable outcome. For large fistulas, spine 
stabilization, screw device removal and repair with blanket muscular flap 
are recommended.
EMTREE DRUG INDEX TERMS
  antibiotic agent; diatrizoate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; esophagus perforation; European; spine stabilization; thorax surgery; 
EMTREE MEDICAL INDEX TERMS
  abscess; case study; chronic respiratory failure; computer assisted tomography; decubitus; device removal; dysphagia; enteric feeding; esophagus; fistula; gastrostomy; human; hyperpyrexia; hypertension; infection; lacrimal fluid; length of stay; mobilization; neck; orthopedic fixation device; pain; patient; pectoralis major muscle; perforation; pharynx; procedures; reinforcement; society; soft tissue; sternocleidomastoid muscle; surgical mortality; suture; swelling; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71997328
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15699293&id=doi:&atitle=Oesophageal+perforation+following+anterior+cervical+spine+fixation%3A+Management+and+results&stitle=Interact.+Cardiovasc.+Thorac.+Surg.&title=Interactive+Cardiovascular+and+Thoracic+Surgery&volume=21&issue=&spage=&epage=&aulast=Daddi&aufirst=Niccol%C3%B2&auinit=N.&aufull=Daddi+N.&coden=&isbn=&pages=-&date=2015&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 328
TITLE
  Respiratory care in neuromuscular disease
AUTHOR NAMES
  Khurshid I.
AUTHOR ADDRESSES
  (Khurshid I.) Linde Sleep and Respiratory Care Center, United Arab Emirates.
CORRESPONDENCE ADDRESS
  I. Khurshid, Linde Sleep and Respiratory Care Center, United Arab Emirates.
FULL RECORD ENTRY DATE
  2017-08-15
SOURCE
  Neurorehabilitation and Neural Repair (2015) 29:7 (NP4-NP5). Date of 
Publication: 1 Aug 2015
VOLUME
  29
ISSUE
  7
FIRST PAGE
  NP4
LAST PAGE
  NP5
DATE OF PUBLICATION
  1 Aug 2015
CONFERENCE NAME
  Abu Dhabi Neuro Rehabilitation Conference 2015 Meeting
CONFERENCE LOCATION
  Abu Dhabi, United Arab Emirates
CONFERENCE DATE
  2015-03-05 to 2015-03-07
ISSN
  1545-9683
BOOK PUBLISHER
  SAGE Publications Inc.
ABSTRACT
  Respiratory muscles including diaphragm constitute the ventilatory pump on 
which the act of breathing depends. In most neuromuscular disorders, there 
is simultaneous respiratory muscle weakness of similar or even greater 
extent than to other skeletal muscles. Causes of neuromuscular weakness: 
cerebral cortex-stroke, seizure disorders, degeneration, neoplasm; 
brainstem/basal ganglia-stroke, postpolio syndrome, progressive bulbar 
palsy, Parkinson's disease, multiple sclerosis; spinal cord-trauma, 
demyelinating disease, disk compression, multiple sclerosis; anterior horn 
cells-motor neuron disease, postpolio syndrome, amyotrophic lateral; 
neuromuscular junction myasthenia gravis, Lambert-Eaton syndrome, drugs 
(steroids, AChE sclerosis, spinal muscular atrophy, primary lateral 
sclerosis inhibitors); myopathies muscular dystrophies, glycogen storage 
disease, polymyositis, dernatomyositis, other myopathies. Major respirator 
problems in patients with neuromuscular disease: pneumonia-aspiration; 
diurnal ventilation failure; sleep disordered breathing. Aspiration 
pneumonia-Caused by oropharyngeal muscle weakness, gastric reflux, and cough 
insufficiency. Aspiration risk factors: Head-end elevation <30°, use of 
sedatives/opioids, low Glasgow Coma Scale score, that is, <9, gastric 
residual volume (>200 cm3), gastroesophageal reflux/vomiting. Diurnal 
ventilatory failure: Respiratory symptoms are often initially absent or 
minimal because of the large reserve of the respiratory system. Respiratory 
muscle involvement may also be masked because patients with skeletal muscle 
weakness spontaneously decrease their overall activity level, thereby 
reducing the daily physiologic challenge faced by the respiratory system. 
For all these reasons, it is not unusual for respiratory muscle weakness to 
go undetected until overt respiratory failure is precipitated by an acute 
episode of pulmonary aspiration or infection. Evaluation. Symptoms and 
signs-unexplained dyspnea on exertion, orthopnea, recurrent cough, choking; 
objective tests; nocturnal pulse oximetry; forced vital capacity (FVC); 
sniff nasal inspiratory pressure (SNIP); arterial blood gases. Treatment. 
Noninvasive positive pressure ventilation (NIPPV)-indications: acute 
respiratory failure secondary to chest infection, perioperative support/ peg 
tube placement, hypercapnic chronic respiratory failure, sleep-disordered 
breathing, during pregnancy, palliate symptoms. Long-term 
ventilation-tracheostomy care (TRACHE): tape-keep tube position secured; 
resuscitation- know the resuscitation process; airway clear-use correct 
suction technique; care of the site-care of stoma and neck; 
humidity-essential to keep tube clear; emergency kit-have the kit ready. 
Obstructive sleep apnea (OSA) in patients with neuromuscular disorders: 
Higher incidence of OSA in patients with neuromuscular disease; need high 
index of suspicion for OSA in these patients; polysomnography (PSG) is the 
test of choice for diagnosis of OSA; NIPPV (CPAP/bilevel) is recommended if 
PSG is positive for OSA.
EMTREE DRUG INDEX TERMS
  acetylcholinesterase; endogenous compound; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  primary lateral sclerosis; respiratory care; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; airway obstruction; anterior horn cell; apnea monitoring; arterial blood; aspiration pneumonia; basal ganglion; blood gas; brain cortex; brain stem; breathing muscle; bulbar paralysis; cerebrovascular accident; chest infection; chronic respiratory failure; clinical study; coughing; diagnosis; diaphragm; dyspnea; Eaton Lambert syndrome; emergency; epilepsy; female; forced vital capacity; gastroesophageal reflux; Glasgow coma scale; glycogen storage disease; head; human; humidity; hypercapnia; hypoventilation; multiple sclerosis; muscular dystrophy; myasthenia gravis; neck; neoplasm; neuromuscular junction; Parkinson disease; polymyositis; polysomnography; postpoliomyelitis syndrome; pregnancy; pulse oximetry; residual volume; resuscitation; risk factor; sleep disordered breathing; spinal cord injury; stoma; stomach; suction; surgery; tracheostomy; ventilator; vomiting; 
CAS REGISTRY NUMBERS
  acetylcholinesterase (9000-81-1)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L617727813
DOI
  10.1177/1545968315589320
FULL TEXT LINK
  http://dx.doi.org/10.1177/1545968315589320
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15459683&id=doi:10.1177%2F1545968315589320&atitle=Respiratory+care+in+neuromuscular+disease&stitle=Neurorehabil.+Neural+Repair&title=Neurorehabilitation+and+Neural+Repair&volume=29&issue=7&spage=NP4&epage=NP5&aulast=Khurshid&aufirst=Imtiaz&auinit=I.&aufull=Khurshid+I.&coden=&isbn=&pages=NP4-NP5&date=2015&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 329
TITLE
  Purely endoscopic endonasal surgery of the craniovertebral junction: A 
systematic review
AUTHOR NAMES
  Fang C.H.; Friedman R.; Schild S.D.; Goldstein I.M.; Baredes S.; Liu J.K.; Eloy J.A.
AUTHOR ADDRESSES
  (Fang C.H.; Friedman R.; Schild S.D.; Baredes S.; Liu J.K.; Eloy J.A., 
jean.anderson.eloy@gmail.com) Department of Otolaryngology-Head and Neck 
Surgery, Rutgers New Jersey Medical School, Newark, United States.
(Goldstein I.M.; Liu J.K.; Eloy J.A., jean.anderson.eloy@gmail.com) 
Department of Neurological Surgery, Rutgers New Jersey Medical School, 
Newark, United States.
(Baredes S.; Liu J.K.; Eloy J.A., jean.anderson.eloy@gmail.com) Center for 
Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, 
Rutgers New Jersey Medical School, Newark, United States.
CORRESPONDENCE ADDRESS
  J.A. Eloy, Rhinology and Sinus Surgery, Otolaryngology Research, Endoscopic 
Skull Base Surgery Program, Department of Otolaryngology-Head and Neck 
Surgery, Rutgers New Jersey Medical School, Neurological Institute of New 
Jersey, 90 Bergen St., Suite 8100, Newark, United States. Email: 
jean.anderson.eloy@gmail.com
AiP/IP ENTRY DATE
  2015-05-28
FULL RECORD ENTRY DATE
  2015-08-12
SOURCE
  International Forum of Allergy and Rhinology (2015) 5:8 (754-760). Date of 
Publication: 1 Aug 2015
VOLUME
  5
ISSUE
  8
FIRST PAGE
  754
LAST PAGE
  760
DATE OF PUBLICATION
  1 Aug 2015
ISSN
  2042-6984 (electronic)
  2042-6976
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Background: Endoscopic endonasal surgery (EES) is a relatively novel 
approach to the craniovertebral junction (CVJ). The purpose of this analysis 
is to determine the surgical outcomes of patients who undergo purely EES of 
the CVJ. Methods: A search for articles related to EES of the CVJ was 
performed using the MEDLINE/PubMed database. A bibliographic search was done 
for additional articles. Demographics, presenting symptoms, imaging 
findings, complications, follow-up, and patient outcomes were analyzed. 
Results: Eighty-five patients from 30 articles were included. The mean 
patient age was 47.9 ± 24.8 years (range, 3 to 96 years), with 44.7% being 
male. The most common presenting symptom was myelopathy (n = 64, 75.3%). The 
most common indications for surgery were brainstem compression secondary to 
basilar invagination (n = 41, 48.2%) and odontoid pannus (n = 20, 23.5%). 
Odontoidectomy was performed in 97.6% of cases. Intraoperative complications 
occurred in 16 patients (18.8%) and postoperative complications occurred in 
18 patients (21.2%). Six patients developed postoperative respiratory 
failure necessitating a tracheostomy. Neurologic improvement was seen in 
89.4% of patients at a mean follow-up of 22.2 months. Conclusion: Our 
analysis found that EES of the CVJ results in a high rate of neurologic 
improvement with acceptable complication rates. Given its minimally invasive 
nature and high success rate, this approach appears to be a reasonable 
alternative to the traditional transoral approach in select cases. This 
study represents the largest pooled sample size of EES of the CVJ to date. 
Increasing use of the endoscopic endonasal approach will allow for further 
studies with greater statistical power.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  craniovertebral junction compression (surgery); endoscopic endonasal surgery; nerve compression (surgery); spinal cord disease (surgery); 
EMTREE MEDICAL INDEX TERMS
  Arnold Chiari malformation; bleeding (complication); cause of death; craniovertebral junction; demography; disease association; dysphagia; epistaxis (complication); follow up; human; image analysis; liquorrhea (complication); meningitis (complication); neck pain; nuclear magnetic resonance imaging; odontoid process fracture (surgery); outcome assessment; palatopharyngeal incompetence (complication); peroperative complication (complication); postoperative complication (complication); priority journal; respiratory failure (complication); review; rheumatoid arthritis; spine; systematic review; wound infection (complication); 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015064073
MEDLINE PMID
  25946171 (http://www.ncbi.nlm.nih.gov/pubmed/25946171)
PUI
  L604482904
DOI
  10.1002/alr.21537
FULL TEXT LINK
  http://dx.doi.org/10.1002/alr.21537
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20426984&id=doi:10.1002%2Falr.21537&atitle=Purely+endoscopic+endonasal+surgery+of+the+craniovertebral+junction%3A+A+systematic+review&stitle=Int.+Forum+Allergy+Rhinol.&title=International+Forum+of+Allergy+and+Rhinology&volume=5&issue=8&spage=754&epage=760&aulast=Fang&aufirst=Christina+H.&auinit=C.H.&aufull=Fang+C.H.&coden=&isbn=&pages=754-760&date=2015&auinit1=C&auinitm=H
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 330
TITLE
  Difficult airway response team: A novel quality improvement program for 
managing hospital-wide airway emergencies
AUTHOR NAMES
  Mark L.J.; Herzer K.R.; Cover R.; Pandian V.; Bhatti N.I.; Berkow L.C.; Haut E.R.; Hillel A.T.; Miller C.R.; Feller-Kopman D.J.; Schiavi A.J.; Xie Y.J.; Lim C.; Holzmueller C.; Ahmad M.; Thomas P.; Flint P.W.; Mirski M.A.
AUTHOR ADDRESSES
  (Mark L.J.; Pandian V.; Berkow L.C.; Miller C.R.; Schiavi A.J.; Thomas P.; 
Mirski M.A., lmark@jhmi.edu) Department of Anesthesiology and Critical Care 
Medicine, Johns Hopkins School of Medicine, 1800 Orleans St., Baltimore, 
United States.
(Herzer K.R.) Medical Scientist Training Program, Johns Hopkins School of 
Medicine, Baltimore, United States.
(Cover R.) Legal Department, Johns Hopkins Hospital, Baltimore, United 
States.
(Mark L.J.; Bhatti N.I.; Berkow L.C.; Hillel A.T.; Feller-Kopman D.J.; Ahmad 
M.) Otolaryngology - Head and Neck Surgery, Johns Hopkins School of 
Medicine, Baltimore, United States.
(Haut E.R.) Surgery, Johns Hopkins School of Medicine, Baltimore, United 
States.
(Feller-Kopman D.J.) Medicine, Johns Hopkins School of Medicine, Baltimore, 
United States.
(Xie Y.J.) MD Program, Johns Hopkins School of Medicine, Baltimore, United 
States.
(Lim C.) MD Program, University of Maryland School of Medicine, Baltimore, 
United States.
(Holzmueller C.) Armstrong Institute for Patient Safety and Quality, Johns 
Hopkins Medicine, Baltimore, United States.
(Flint P.W.) Otolaryngology/Head and Neck Surgery, Oregon Health and Science 
University, Portland, United States.
CORRESPONDENCE ADDRESS
  M.A. Mirski, Department of Anesthesiology and Critical Care Medicine, Johns 
Hopkins School of Medicine, 1800 Orleans St., Baltimore, United States. 
Email: lmark@jhmi.edu
AiP/IP ENTRY DATE
  2015-10-08
FULL RECORD ENTRY DATE
  2015-10-13
SOURCE
  Anesthesia and Analgesia (2015) 121:1 (127-139). Date of Publication: 4 Jul 
2015
VOLUME
  121
ISSUE
  1
FIRST PAGE
  127
LAST PAGE
  139
DATE OF PUBLICATION
  4 Jul 2015
ISSN
  1526-7598 (electronic)
  0003-2999
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  BACKGROUND: Difficult airway cases can quickly become emergencies, 
increasing the risk of life-threatening complications or death. Emergency 
airway management outside the operating room is particularly challenging. 
METHODS: We developed a quality improvement program - the Difficult Airway 
Response Team (DART) - to improve emergency airway management outside the 
operating room. DART was implemented by a team of anesthesiologists, 
otolaryngologists, trauma surgeons, emergency medicine physicians, and risk 
managers in 2005 at The Johns Hopkins Hospital in Baltimore, Maryland. The 
DART program had 3 core components: operations, safety, and education. The 
operations component focused on developing a multidisciplinary difficult 
airway response team, standardizing the emergency response process, and 
deploying difficult airway equipment carts throughout the hospital. The 
safety component focused on real-time monitoring of DART activations and 
learning from past DART events to continuously improve system-level 
performance. This objective entailed monitoring the paging system, reporting 
difficult airway events and DART activations to a Web-based registry, and 
using in situ simulations to identify and mitigate defects in the emergency 
airway management process. The educational component included development of 
a multispecialty difficult airway curriculum encompassing case-based 
lectures, simulation, and team building/communication to ensure consistency 
of care. Educational materials were also developed for non-DART staff and 
patients to inform them about the needs of patients with difficult airways 
and ensure continuity of care with other providers after discharge. RESULTS: 
Between July 2008 and June 2013, DART managed 360 adult difficult airway 
events comprising 8% of all code activations. Predisposing patient factors 
included body mass index >40, history of head and neck tumor, prior 
difficult intubation, cervical spine injury, airway edema, airway bleeding, 
and previous or current tracheostomy. Twenty-three patients (6%) required 
emergent surgical airways. Sixty-two patients (17%) were stabilized and 
transported to the operating room for definitive airway management. There 
were no airway management-related deaths, sentinel events, or malpractice 
claims in adult patients managed by DART. Five in situ simulations conducted 
in the first program year improved DART's teamwork, communication, and 
response times and increased the functionality of the difficult airway 
carts. Over the 5-year period, we conducted 18 airway courses, through which 
>200 providers were trained. CONCLUSIONS: DART is a comprehensive program 
for improving difficult airway management. Future studies will examine the 
comparative effectiveness of the DART program and evaluate how DART has 
impacted patient outcomes, operational efficiency, and costs of care.
EMTREE DRUG INDEX TERMS
  local anesthetic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency care; respiration control; 
EMTREE MEDICAL INDEX TERMS
  adult; article; body mass; cervical spine injury; edema; emergency physician; female; head and neck tumor; human; major clinical study; male; operating room; patient safety; priority journal; rapid response team; reaction time; simulation; total quality management; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015419091
MEDLINE PMID
  26086513 (http://www.ncbi.nlm.nih.gov/pubmed/26086513)
PUI
  L606253849
DOI
  10.1213/ANE.0000000000000691
FULL TEXT LINK
  http://dx.doi.org/10.1213/ANE.0000000000000691
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15267598&id=doi:10.1213%2FANE.0000000000000691&atitle=Difficult+airway+response+team%3A+A+novel+quality+improvement+program+for+managing+hospital-wide+airway+emergencies&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=121&issue=1&spage=127&epage=139&aulast=Mark&aufirst=Lynette+J.&auinit=L.J.&aufull=Mark+L.J.&coden=AACRA&isbn=&pages=127-139&date=2015&auinit1=L&auinitm=J
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 331
TITLE
  Evolution in the Management of Aberrant Subclavian Arteries and Related 
Kommerell Diverticulum
AUTHOR NAMES
  Van Bogerijen G.H.W.; Patel H.J.; Eliason J.L.; Criado E.; Williams D.M.; Knepper J.; Yang B.; Deeb G.M.
AUTHOR ADDRESSES
  (Van Bogerijen G.H.W.; Patel H.J., hjpatel@med.umich.edu; Yang B.; Deeb 
G.M.) Department of Cardiac Surgery, University of Michigan, Frankel 
Cardiovascular Center, 1500 E Medical Center Dr, 5144 Cardiovascular 
Center/SPC 5864, Ann Arbor, United States.
(Eliason J.L.; Criado E.; Knepper J.) Department of Vascular Surgery, 
University of Michigan, Frankel Cardiovascular Center, Ann Arbor, United 
States.
(Williams D.M.) Department of Radiology, University of Michigan, Frankel 
Cardiovascular Center, Ann Arbor, United States.
CORRESPONDENCE ADDRESS
  H.J. Patel, Department of Cardiac Surgery, University of Michigan, Frankel 
Cardiovascular Center, 1500 E Medical Center Dr, 5144 Cardiovascular 
Center/SPC 5864, Ann Arbor, United States. Email: hjpatel@med.umich.edu
AiP/IP ENTRY DATE
  2015-04-28
FULL RECORD ENTRY DATE
  2015-07-13
SOURCE
  Annals of Thoracic Surgery (2015) 100:1 (47-53) Article Number: 27971. Date 
of Publication: 1 Jul 2015
VOLUME
  100
ISSUE
  1
FIRST PAGE
  47
LAST PAGE
  53
DATE OF PUBLICATION
  1 Jul 2015
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background Various options have been described to treat aberrant subclavian 
arteries and associated Kommerell diverticulum. We describe our experience 
with the management of this entity over a 15-year period. Methods Twenty-two 
patients underwent repair of aberrant subclavian arteries and associated 
Kommerell diverticulum. Indications for intervention included a large 
Kommerell diverticulum (n = 18), dysphagia lusoria (n = 12), rupture (n = 
4), type B aortic dissection (n = 4), thoracic aortic aneurysm (n = 2), and 
coarctation (n = 1). Patients were treated with either open surgery (n = 9) 
or an endovascular approach (n = 13). For the open surgical patients, 
hypothermic circulatory arrest (n = 7) or left heart bypass (n = 2) was 
used. For those patients undergoing an endovascular approach (n = 13), 
carotid to subclavian arterial bypasses were performed preoperatively in 11 
patients and intraoperatively in 2 patients. Bilateral revascularization was 
more frequently performed with endovascular repair compared with open 
surgery (69% vs 22%, p = 0.01). Results Early outcomes included in-hospital 
mortality (n = 1), stroke (n = 1), and permanent spinal cord ischemia (n = 
1) after endovascular approaches, and renal failure requiring dialysis (n = 
1) and need for tracheostomy (n = 1) after open repair. The frequency of 
endovascular repair increased after the commercialization of thoracic 
endovascular aortic repair in 2005 from 33% to 63%. Four patients developed 
type I (n = 1) or type II (n = 3) endoleaks, of which 1 required 
reintervention. Median hospital stay was 7 days (interquartile range 4 to 
17). Five-year survival was 81.8%. No late aortic ruptures occurred and 3 
patients required late reintervention; 1 after an open and 2 after an 
endovascular approach. Dysphagia lusoria was relieved in all patients except 
for 1 in the open repair and 1 in the endovascular group. Conclusions 
Aberrant subclavian arteries and associated Kommerell diverticulum can be 
treated with acceptable rates of mortality and morbidity. The evolution 
toward an endovascular approach did not appear to affect late outcomes, 
suggesting that the choice of treatment should be based on patient-specific 
anatomy and associated comorbidities.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aberrant subclavian artery (congenital disorder, surgery); congenital blood vessel malformation (congenital disorder, surgery); diverticulosis (congenital disorder, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; aortic coarctation (surgery); aortic dissection (surgery); aortic rupture (surgery); article; cardiovascular mortality; cerebrovascular accident; clinical article; dysphagia (surgery); endoleak (complication); endovascular aneurysm repair; endovascular surgery; extracorporeal circulation; female; frequency; hospitalization; human; kidney failure; male; middle aged; morbidity; open heart surgery; postoperative complication (complication); priority journal; retrospective study; spinal cord ischemia; subclavian artery; survival; thoracic aorta aneurysm (surgery); treatment outcome; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015958829
MEDLINE PMID
  25912743 (http://www.ncbi.nlm.nih.gov/pubmed/25912743)
PUI
  L603964490
DOI
  10.1016/j.athoracsur.2015.02.027
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2015.02.027
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2015.02.027&atitle=Evolution+in+the+Management+of+Aberrant+Subclavian+Arteries+and+Related+Kommerell+Diverticulum&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=100&issue=1&spage=47&epage=53&aulast=Van+Bogerijen&aufirst=Guido+H.W.&auinit=G.H.W.&aufull=Van+Bogerijen+G.H.W.&coden=ATHSA&isbn=&pages=47-53&date=2015&auinit1=G&auinitm=H.W.
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 332
TITLE
  The influence factors and meanings of tracheotomy after cervical spinal cord 
injury
AUTHOR NAMES
  Zhang P.; Zhang X.
AUTHOR ADDRESSES
  (Zhang P.; Zhang X.)
FULL RECORD ENTRY DATE
  2016-12-13
SOURCE
  Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
otorhinolaryngology, head, and neck surgery (2015) 29:11 (1046-1049). Date 
of Publication: 1 Jun 2015
VOLUME
  29
ISSUE
  11
FIRST PAGE
  1046
LAST PAGE
  1049
DATE OF PUBLICATION
  1 Jun 2015
ISSN
  1001-1781
ABSTRACT
  Cervical spinal cord injury is a common and serious disease in clinic, and 
tracheotomy combined with mechanical ventilation is an effective way to 
prevent respiratory complications. Although tracheotomy is used widely, 
there are not unified indications of tracheotomy after cervical spinal cord 
injury in the practical application. At the same time, the advantages and 
disadvantages of the application of tracheotomy in patients with cervical 
spinal cord injury are still on dispute. Based on the recent literature, we 
summarize the influence factors and meanings of tracheotomy after cervical 
spinal cord injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; cervical spinal cord; human; injuries; neck injury; 
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  26536718 (http://www.ncbi.nlm.nih.gov/pubmed/26536718)
PUI
  L613598987
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10011781&id=doi:&atitle=The+influence+factors+and+meanings+of+tracheotomy+after+cervical+spinal+cord+injury&stitle=Lin+Chung+Er+Bi+Yan+Hou+Tou+Jing+Wai+Ke+Za+Zhi&title=Lin+chuang+er+bi+yan+hou+tou+jing+wai+ke+za+zhi+%3D+Journal+of+clinical+otorhinolaryngology%2C+head%2C+and+neck+surgery&volume=29&issue=11&spage=1046&epage=1049&aulast=Zhang&aufirst=Pu&auinit=P.&aufull=Zhang+P.&coden=&isbn=&pages=1046-1049&date=2015&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2016 Medline is the source for the citation and abstract of this 
record.

RECORD 333
TITLE
  Caesarean section in a parturient with preexisting Transverse myelitis: An 
anaesthetist's dilemma
AUTHOR NAMES
  Iyer S.J.
AUTHOR ADDRESSES
  (Iyer S.J.) KK Women and Children's Hospital, Singapore.
CORRESPONDENCE ADDRESS
  S.J. Iyer, KK Women and Children's Hospital, Singapore.
FULL RECORD ENTRY DATE
  2018-08-14
SOURCE
  Acta Anaesthesiologica Scandinavica (2015) 59 Supplement 121 (58). Date of 
Publication: 1 Jun 2015
VOLUME
  59
FIRST PAGE
  58
DATE OF PUBLICATION
  1 Jun 2015
CONFERENCE NAME
  33rd Congress of the Scandinavian Society of Anaesthesiology and Intensive 
Care Medicine, SSAI 2015
CONFERENCE LOCATION
  Reykjavik, Iceland
CONFERENCE DATE
  2015-06-10 to 2015-06-10
ISSN
  1399-6576
BOOK PUBLISHER
  Blackwell Munksgaard
ABSTRACT
  Introduction: Transverse myelitis is an inflammatory, spinal cord disorder 
causing motor, sensory and autonomic dysfunction. Pregnancy in patients with 
pre-existing transverse myelitis is extremely uncommon. There are several 
anaesthetic challenges to consider when these patients present for surgery. 
These include autonomic dysreflexia, hyperkalemia following use of 
succinylcholine, poor respiratory reserve and possible diaphragmatic 
paralysis in patients with high lesions. In addition, there is potential for 
both general and neuraxial anaesthesia to aggravate symptoms of pre-existing 
transverse myelitis. Case description: We discuss the management of a 
35-year-old Malay primigravida presenting for elective Caesarean section at 
term pregnancy. She was diagnosed with transverse myelitis 20 years ago, 
associated with tetraplegia and neurogenic bladder. Cervical spine MRI 
revealed a high lesion at the C5-C6 interval. She also had a previous 
history of tracheostomy secondary to prolonged ventilation at time of her 
diagnosis. Given these considerations and the concern of autonomic 
dysreflexia, decision was made to proceed with spinal anaesthesia instead of 
general anaesthesia. Intra-operative course was uneventful with stable 
hemodynamics and delivery of a healthy newborn. Post-operatively, patient 
had delayed recovery of both sensory and motor components, taking 30 h to 
return to baseline levels, but she was subsequently well and discharged 
home. Discussion: We discuss the merits of neuraxial anaesthesia vs general 
anaesthesia in this rare group of patients, for who there is limited 
evidence in literature for management. Treatment should be should be 
individualised, along with multi-disciplinary approach and careful planning 
for safe provision of anaesthesia in these mothers.
EMTREE DRUG INDEX TERMS
  suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesist; cesarean section; spinal cord disease; 
EMTREE MEDICAL INDEX TERMS
  adult; adverse drug reaction; autonomic dysreflexia; case report; cervical spine; clinical article; conference abstract; diagnosis; diaphragm paralysis; female; general anesthesia; hemodynamics; human; hyperkalemia; mother; neurogenic bladder; newborn; nuclear magnetic resonance imaging; primigravida; quadriplegia; remission; sensory dysfunction; side effect; spinal anesthesia; surgery; tracheostomy; 
CAS REGISTRY NUMBERS
  suxamethonium (306-40-1, 71-27-2)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L623414972
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13996576&id=doi:&atitle=Caesarean+section+in+a+parturient+with+preexisting+Transverse+myelitis%3A+An+anaesthetist%27s+dilemma&stitle=Acta+Anaesthesiol.+Scand.&title=Acta+Anaesthesiologica+Scandinavica&volume=59&issue=&spage=58&epage=&aulast=Iyer&aufirst=Srividhya+Jayant&auinit=S.J.&aufull=Iyer+S.J.&coden=&isbn=&pages=58-&date=2015&auinit1=S&auinitm=J
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 334
TITLE
  A rare case of medulloblastoma coexisting with multiple spinal 
intramedullary tumors
AUTHOR NAMES
  Rege S.; Gupta R.; Awasthi R.
AUTHOR ADDRESSES
  (Rege S.; Gupta R.; Awasthi R., dr.awasthir@gmail.com) Department of 
Neurosurgery, Sri Aurobindo Medical College and PG Institute, 306 Sanskar 
Hostel, Indore, Madhya Pradesh, India.
AiP/IP ENTRY DATE
  2015-04-09
FULL RECORD ENTRY DATE
  2015-06-16
SOURCE
  Pediatric Neurosurgery (2015) 50:2 (80-83). Date of Publication: 1 Jun 2015
VOLUME
  50
ISSUE
  2
FIRST PAGE
  80
LAST PAGE
  83
DATE OF PUBLICATION
  1 Jun 2015
ISSN
  1423-0305 (electronic)
  1016-2291
BOOK PUBLISHER
  S. Karger AG
ABSTRACT
  Medulloblastoma is the most common primary central nervous system tumor of 
childhood. Medulloblastoma can metastasize along the neuraxis and to 
extraneural locations, but multiple intramedullary spinal metastases are 
very rare. The usual presenting clinical features are related to posterior 
fossa syndrome and/or hydrocephalus. We describe a unique case of 
medulloblastoma with multiple intramedullary lesions at the D-7 and D-12 
levels.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood cancer (surgery); medulloblastoma (surgery); multiple cancer (surgery); spinal cord tumor (surgery); spinal intramedullary tumor (surgery); 
EMTREE MEDICAL INDEX TERMS
  antibiotic therapy; article; ataxia; backache; bradycardia; brain ventricle peritoneum shunt; breathing exercise; cancer surgery; case report; cause of death; chest infection; child; contrast enhancement; craniectomy; cytoreductive surgery; deterioration; eye examination; fever; headache; histopathology; human; hydrocephalus; intracranial pressure; leg pain; male; medical history; nuclear magnetic resonance imaging; papilledema; pediatric surgery; pneumonia (drug therapy, therapy); posterior fossa; postoperative complication; postoperative infection; priority journal; recurrent disease; school child; sitting; supine position; thorax radiography; tracheostomy; unsteady gait; ventriculostomy catheter; vomiting; walking; 
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015888089
MEDLINE PMID
  25832201 (http://www.ncbi.nlm.nih.gov/pubmed/25832201)
PUI
  L603557604
DOI
  10.1159/000377729
FULL TEXT LINK
  http://dx.doi.org/10.1159/000377729
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14230305&id=doi:10.1159%2F000377729&atitle=A+rare+case+of+medulloblastoma+coexisting+with+multiple+spinal+intramedullary+tumors&stitle=Pediatr.+Neurosurg.&title=Pediatric+Neurosurgery&volume=50&issue=2&spage=80&epage=83&aulast=Rege&aufirst=Shrikant&auinit=S.&aufull=Rege+S.&coden=PDNEE&isbn=&pages=80-83&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 335
TITLE
  Respiratory dysfunction in multiple sclerosis
AUTHOR NAMES
  Tzelepis G.E.; McCool F.D.
AUTHOR ADDRESSES
  (Tzelepis G.E., gtzelep@med.uoa.gr; McCool F.D.) Department of 
Pathophysiology, Laiko General Hospital, University of Athens Medical 
School, Athens, Greece.
(Tzelepis G.E., gtzelep@med.uoa.gr; McCool F.D.) Department of Pulmonary and 
Critical Care Medicine, Memorial Hospital RI, Warren Alpert Medical School 
of Brown University, Providence, United States.
CORRESPONDENCE ADDRESS
  G.E. Tzelepis, Department of Pulmonary and Critical Care Medicine, Memorial 
Hospital RI, Warren Alpert Medical School of Brown University, Providence, 
United States. Email: gtzelep@med.uoa.gr
AiP/IP ENTRY DATE
  2015-03-03
FULL RECORD ENTRY DATE
  2015-07-06
SOURCE
  Respiratory Medicine (2015) 109:6 (671-679). Date of Publication: 1 Jun 2015
VOLUME
  109
ISSUE
  6
FIRST PAGE
  671
LAST PAGE
  679
DATE OF PUBLICATION
  1 Jun 2015
ISSN
  1532-3064 (electronic)
  0954-6111
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Respiratory dysfunction frequently occurs in patients with advanced multiple 
sclerosis (MS), and may manifest as acute or chronic respiratory failure, 
disordered control of breathing, respiratory muscle weakness, sleep 
disordered breathing, or neurogenic pulmonary edema. The underlying 
pathophysiology is related to demyelinating plaques involving the brain stem 
or spinal cord. Respiratory complications such as aspiration, lung 
infections and respiratory failure are typically seen in patients with 
long-standing MS. Acute respiratory failure is uncommon and due to newly 
appearing demyelinating plaques extensively involving areas of the brain 
stem or spinal cord. Early recognition of MS patients at risk for 
respiratory complications allows for the timely implementation of care and 
measures to decrease disease associated morbidity and mortality.
EMTREE DRUG INDEX TERMS
  methylprednisolone; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  multiple sclerosis; respiratory failure (complication, etiology, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure (complication); anamnesis; apnea; arm weakness; artificial ventilation; aspiration pneumonia (complication); atelectasis; brain stem; breathing disorder (complication); breathing exercise; breathing muscle; breathing pattern; bulbar paralysis; chronic respiratory failure (complication); cognitive defect; coughing; daytime somnolence; exercise; Expanded Disability Status Scale; fatigue; forced vital capacity; human; hypoventilation; immobility; insomnia; libido disorder; limited mobility; lung edema (complication); lung function; lung function test; lung infection (complication); lung minute volume; lung ventilation; mood change; motor dysfunction; muscle strength; muscle training; muscle weakness; noninvasive ventilation; pathophysiology; physical examination; plasmapheresis; polysomnography; priority journal; quadriplegia; residual volume; respiration center; respiration control; respiratory arrest; restlessness; review; risk assessment; sleep disordered breathing (complication); spastic paraplegia; spinal cord; standing; supine position; thorax pressure; tidal volume; total lung capacity; tracheostomy; vital capacity; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015778032
MEDLINE PMID
  25724874 (http://www.ncbi.nlm.nih.gov/pubmed/25724874)
PUI
  L602521466
DOI
  10.1016/j.rmed.2015.01.018
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rmed.2015.01.018
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15323064&id=doi:10.1016%2Fj.rmed.2015.01.018&atitle=Respiratory+dysfunction+in+multiple+sclerosis&stitle=Respir.+Med.&title=Respiratory+Medicine&volume=109&issue=6&spage=671&epage=679&aulast=Tzelepis&aufirst=George+E.&auinit=G.E.&aufull=Tzelepis+G.E.&coden=RMEDE&isbn=&pages=671-679&date=2015&auinit1=G&auinitm=E
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 336
TITLE
  Diffuse leptomeningeal carcinomatosis mimicking brain death
AUTHOR NAMES
  Kung N.H.; Dhar R.; Keyrouz S.G.
AUTHOR ADDRESSES
  (Kung N.H., kungn@neuro.wustl.edu; Dhar R., dharr@neuro.wustl.edu; Keyrouz 
S.G., keyrouzs@neuro.wustl.edu) Department of Neurology, Washington 
University in St. Louis, 660 South Euclid Avenue, Box 8111, Saint Louis, 
United States.
CORRESPONDENCE ADDRESS
  N.H. Kung, Department of Neurology, Washington University in St. Louis, 660 
South Euclid Avenue, Box 8111, Saint Louis, United States.
AiP/IP ENTRY DATE
  2015-04-20
FULL RECORD ENTRY DATE
  2015-05-15
SOURCE
  Journal of the Neurological Sciences (2015) 352:1-2 (132-134) Article 
Number: 13724. Date of Publication: 15 May 2015
VOLUME
  352
ISSUE
  1-2
FIRST PAGE
  132
LAST PAGE
  134
DATE OF PUBLICATION
  15 May 2015
ISSN
  1878-5883 (electronic)
  0022-510X
BOOK PUBLISHER
  Elsevier
EMTREE DRUG INDEX TERMS
  alkaline phosphatase (drug toxicity); antineoplastic agent (drug therapy); technetium 99m; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain death; carcinomatous meningitis (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; alkaline phosphatase blood level; apnea; areflexia; article; bone metastasis (diagnosis); bone pain; breast carcinoma (drug therapy); cancer chemotherapy; cancer diagnosis; case report; cauda equina; cerebrospinal fluid analysis; cerebrospinal fluid cytology; electrodiagnosis; electroencephalography; epileptic discharge; facial nerve paralysis; female; hospital admission; hospital readmission; human; human cell; hypercalcemia; hypercapnia (surgery, therapy); intensive care unit; lack of drug effect; limb weakness; mental deterioration; metabolic acidosis; metastatic breast carcinoma; middle aged; neurologic examination; nuclear magnetic resonance imaging; ophthalmoplegia; paraplegia; pressure support ventilation; priority journal; radiculopathy (diagnosis); respiratory failure (surgery, therapy); spinal cord compression; systemic therapy; tracheostomy; uremia; 
CAS REGISTRY NUMBERS
  alkaline phosphatase (9001-78-9)
  technetium 99m (14133-76-7)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2015917574
MEDLINE PMID
  25881953 (http://www.ncbi.nlm.nih.gov/pubmed/25881953)
PUI
  L603715763
DOI
  10.1016/j.jns.2015.03.045
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jns.2015.03.045
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18785883&id=doi:10.1016%2Fj.jns.2015.03.045&atitle=Diffuse+leptomeningeal+carcinomatosis+mimicking+brain+death&stitle=J.+Neurol.+Sci.&title=Journal+of+the+Neurological+Sciences&volume=352&issue=1-2&spage=132&epage=134&aulast=Kung&aufirst=Nathan+H.&auinit=N.H.&aufull=Kung+N.H.&coden=JNSCA&isbn=&pages=132-134&date=2015&auinit1=N&auinitm=H
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 337
TITLE
  Spinal muscular atrophy: Review of clinical characteristics and treatment in 
the last 25 years
AUTHOR NAMES
  Calvo Medina R.; Madrid Rodríguez A.; Peláez Cantero M.J.; Martínez-Martínez P.L.; Ramos Fernández J.M.; Moreno Medinilla E.; Mora Ramírez M.D.; Martínez Antón J.; Urda Cardona A.
AUTHOR ADDRESSES
  (Calvo Medina R.; Madrid Rodríguez A.; Peláez Cantero M.J.; 
Martínez-Martínez P.L.; Ramos Fernández J.M.; Moreno Medinilla E.; Mora 
Ramírez M.D.; Martínez Antón J.; Urda Cardona A.) Paediatric Neurology CMU 
(Clinical Management Unit), Hospital Materno-Infantil (Maternity and Child 
Hospital), HRU Carlos Haya, Málaga, Spain.
CORRESPONDENCE ADDRESS
  R. Calvo Medina, Paediatric Neurology CMU (Clinical Management Unit), 
Hospital Materno-Infantil (Maternity and Child Hospital), HRU Carlos Haya, 
Málaga, Spain.
FULL RECORD ENTRY DATE
  2015-08-08
SOURCE
  European Journal of Paediatric Neurology (2015) 19 SUPPL. 1 (S65). Date of 
Publication: May 2015
VOLUME
  19
FIRST PAGE
  S65
DATE OF PUBLICATION
  May 2015
CONFERENCE NAME
  11th European Paediatric Neurology Society Congress, EPNS 2015
CONFERENCE LOCATION
  Vienna, Austria
CONFERENCE DATE
  2015-05-27 to 2015-05-30
ISSN
  1090-3798
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Objective: Spinal muscular atrophy (SMA) include a group of disorders that 
produce disabilities in all patients. Our aim is to review the 
epidemiological and clinical characteristics, genetic distribution and to 
analyze the care and development of the SMA in our area. Methods: 
Retrospective descriptive study of patients diagnosed in our hospital during 
the past 25 years (1987-2013), with clinical and neurophysiological 
diagnosis of SMA. Results: 37 patients were found, representing an incidence 
of 1 case per 10,000 live births in our reference population. The 
male/female ratio was 1.6/1. The type of SMA diagnosed more frequently was 
type I (26 cases), followed by type II with 9 cases, 1 case of SMA type III, 
and 1 case of SMA with respiratory distress (SMARD1). The most frequent 
genetic alteration was homozygous deletion of exons 7 and 8 of the SMN1 gene 
(31 cases). 25 patients were followed in our centre, 7 by the Pediatric Home 
Hospitalisation Unit. Most of them received motor rehabilitation (15), 
breathing physiotherapy in 8 cases or basic respiratory care in 5. 2 cases 
received oxygen by low-flow nasal cannula, non-invasive ventilation in 1 
case and invasive ventilation with tracheostomy in 2 cases. In 4 cases a 
nasogastric tube and in 1 case a gastrostomy was prescribed. The median 
survival for type I was 8.0 months and 15.8 years for type II. Conclusion: 
The incidence in our population remains stable at around 1/10.000. Most 
cases presented a typical genetic alteration and were predominantly male. In 
approximately 1/10 patients the genetic alteration was different from the 
classical to the SMN gene. The caring level has increased in line with 
social and welfare demands in recent years. We improve our work with 
consensus statement for standard of care in spinal muscular atrophy.
EMTREE DRUG INDEX TERMS
  oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  European; neurology; society; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; breathing; consensus; diagnosis; disability; diseases; exon; gastrostomy; gene; genetic trait; health care quality; hospital; human; live birth; male; nasal cannula; nasogastric tube; noninvasive ventilation; patient; physiotherapy; population; rehabilitation; respiratory care; respiratory distress; survival; tracheostomy; welfare; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71964414
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10903798&id=doi:&atitle=Spinal+muscular+atrophy%3A+Review+of+clinical+characteristics+and+treatment+in+the+last+25+years&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=19&issue=&spage=S65&epage=&aulast=Calvo+Medina&aufirst=R.&auinit=R.&aufull=Calvo+Medina+R.&coden=&isbn=&pages=S65-&date=2015&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 338
TITLE
  Amyotrophic lateral sclerosis with juvenile onset. Case report
AUTHOR NAMES
  Nechay A.; Stetsenko T.; Savchenko O.
AUTHOR ADDRESSES
  (Nechay A.; Stetsenko T.; Savchenko O.) Neurology Department, Municipal 
Paediatric Hospital No. 1 of c. Kiev, Ukraine.
CORRESPONDENCE ADDRESS
  A. Nechay, Neurology Department, Municipal Paediatric Hospital No. 1 of c. 
Kiev, Ukraine.
FULL RECORD ENTRY DATE
  2015-08-08
SOURCE
  European Journal of Paediatric Neurology (2015) 19 SUPPL. 1 (S122-S123). 
Date of Publication: May 2015
VOLUME
  19
FIRST PAGE
  S122
LAST PAGE
  S123
DATE OF PUBLICATION
  May 2015
CONFERENCE NAME
  11th European Paediatric Neurology Society Congress, EPNS 2015
CONFERENCE LOCATION
  Vienna, Austria
CONFERENCE DATE
  2015-05-27 to 2015-05-30
ISSN
  1090-3798
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Objective: To present clinical symptoms of ALS in 16 year adolescent and 
approaches to differential diagnosis. Methods: Case notes review. Results: A 
boy 16 years old at presentation, born from non-consanguineous parents, 
without evidence of weakness in relatives, had normal development. Aged 15 
years he gradually developed weakness in legs, arms, more prominent on the 
left side. During 9 month he lost ability to walk, stand, seat, lift arms 
and control head. On neurological examination he presented with pronounced 
tetraparesis more prominent on the left proximally. Muscle strength was 
decreased. Muscle hypotonus, hypotrophy of limbs and neck, mild 
fibrillations of tongue and proximal arm muscles were observed. Tendon 
reflexes were high and asymmetric but absent ankle jerk reflexes. Patient 
had swallowing difficulties due to mild bulbar paresis, had pyramid signs, 
mosaic impairment of sensitivity of neuronal type and superficial breathing. 
Traumatic spine injury, tick-borne encephalitis, SMAIII were excluded. CSF 
analysis: protein - 0.93 g/l, glucose - 4.08 mmol/l, cytosis-2 lymphocytes, 
Pandy's reaction +. PCR to EBV, HSV1/2, CMV - negative. HIV-test - negative. 
Antibodies to Flavivirus were negative. Intramuscular EMG showed denervation 
and potentials of fasciculation, NCS revealed decreasing of velocity on left 
peroneal and both femoral nerves to 20%. First brain and spine MRI were 
normal. MRI in 10 month after debut of illness revealed foci of increased 
signal on TIRM in T1- 33, T2-33, T2-TIRM, D-33, SWI in posterior parts of 
the internal capsule 5-6 mm symmetrically. ALS had been diagnosed. 
Management mainly consisted of breathing support. The boy suffered from 
recurrent pneumonia, had tracheotomy. 1 year follow-up demonstrated steady 
course of the disease. The boy is normal intellectually, but has profound 
tetraparesis, fibrillations, breathing disturbances. Conclusion: The 
diagnosis has been based on El Escorial Criteria for the Diagnosis of ALS 
(1998). Clinical symptoms still stay the main part of the diagnosis of ALS.
EMTREE DRUG INDEX TERMS
  antibody; glucose; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis; case report; European; human; juvenile; neurology; society; 
EMTREE MEDICAL INDEX TERMS
  achilles reflex; adolescent; arm; arm muscle; boy; brain; breathing; capsula interna; cerebrospinal fluid; denervation; development; diagnosis; differential diagnosis; diseases; electromyogram; fasciculation; femoral nerve; Flavivirus; follow up; HIV test; Human immunodeficiency virus; hypotrophy; leg; limb; lymphocyte; male; mosaicism; muscle hypotonia; muscle strength; neck; neurologic examination; nuclear magnetic resonance imaging; parent; paresis; patient; pneumonia; protein analysis; quadriplegia; reflex; spine; spine injury; swallowing; tendon reflex; tick borne encephalitis; tongue; tracheotomy; velocity; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71964614
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10903798&id=doi:&atitle=Amyotrophic+lateral+sclerosis+with+juvenile+onset.+Case+report&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=19&issue=&spage=S122&epage=S123&aulast=Nechay&aufirst=A.&auinit=A.&aufull=Nechay+A.&coden=&isbn=&pages=S122-S123&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 339
TITLE
  An anterior cervical spinal cord infarct in a first trimester
AUTHOR NAMES
  Patel A.; Hassan S.; Richardson K.; Davies R.
AUTHOR ADDRESSES
  (Patel A.; Hassan S.; Davies R.) Wirral University Teaching Hospital, 
Wirral, United Kingdom.
(Richardson K.) Royal Liverpool University Hospital, Liverpool, United 
Kingdom.
CORRESPONDENCE ADDRESS
  A. Patel, Wirral University Teaching Hospital, Wirral, United Kingdom.
FULL RECORD ENTRY DATE
  2016-04-13
SOURCE
  Cerebrovascular Diseases (2015) 39 SUPPL. 2 (257). Date of Publication: May 
2015
VOLUME
  39
FIRST PAGE
  257
DATE OF PUBLICATION
  May 2015
CONFERENCE NAME
  24th European Stroke Conference
CONFERENCE LOCATION
  Vienna, Austria
CONFERENCE DATE
  2015-05-13 to 2015-05-15
ISSN
  1015-9770
BOOK PUBLISHER
  S. Karger AG
ABSTRACT
  Background: Spinal cord infarcts (SCI) are most often seen in the presence 
of atherosclerotic disease or as a complication of aortic surgery. There are 
few reported cases of SCI's during pregnancy, and unfortunately, mortality 
and morbidity are high. We report a case of an anterior SCI in young woman 
whose only risk factor was pregnancy; detection was swift, management 
timely, and - following rehabilitation- a near complete recovery was 
achieved. Case: A 27 year old woman, 12 weeks gestation, presented to our 
hospital with a rapid onset weakness following 8 hours of paraesthesia in 
all of her limbs. She required intubation and ventilation following 
respiratory compromise and was subsequently transferred to the Critical Care 
Unit. Magnetic resonance imaging of her brain and spinal cord showed 
increased signal in the cervical spine extending into the medulla 
-consistent with a SCI. Infective, thrombophilia, and vasculitic screens 
were negative; as were transthoracic bubble echocardiogram and lupus ratio. 
The patient was extubated and had an early tracheostomy performed to help 
monitor her neurological recovery. After several days she regained motor and 
sensory function and was weaned from ventilatory support. Early 
rehabilitation was commenced on transferal to the acute stroke unit; she was 
discharged with early supported discharge team input. 2 months later the 
patient was independently mobile -swimming 3 times a week; sensation had 
returned to normal. Her Modified Clinical Outcomes Variable Scale score had 
improved to 91/91 -from 83 at the start of rehabilitation. The patient 
remained on low molecular weight heparin; 20 week growth scan was normal and 
the baby was healthy and of good size. Conclusion: A SCI is a rare and life 
threatening condition that must be considered as a differential in all 
patients with rapidly progressing neurology. Although unusual it can present 
in the young; here early diagnosis and support is essential to enable 
recovery.
EMTREE DRUG INDEX TERMS
  low molecular weight heparin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cerebrovascular accident; cervical spinal cord; European; first trimester pregnancy; infarction; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; aortic surgery; baby; brain; cervical spine; early diagnosis; echocardiography; female; hospital; human; intensive care; intubation; limb; morbidity; mortality; neurology; nuclear magnetic resonance imaging; paresthesia; patient; pregnancy; rehabilitation; risk factor; sensation; spinal cord; stroke unit; swimming; thrombophilia; tracheostomy; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72223861
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10159770&id=doi:&atitle=An+anterior+cervical+spinal+cord+infarct+in+a+first+trimester&stitle=Cerebrovasc.+Dis.&title=Cerebrovascular+Diseases&volume=39&issue=&spage=257&epage=&aulast=Patel&aufirst=A.&auinit=A.&aufull=Patel+A.&coden=&isbn=&pages=257-&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 340
TITLE
  Chronic spinal cord injury treated with transplanted autologous bone 
marrow-derived mesenchymal stem cells tracked by magnetic resonance imaging: 
A case report
AUTHOR NAMES
  Chotivichit A.; Ruangchainikom M.; Chiewvit P.; Wongkajornsilp A.; Sujirattanawimol K.
AUTHOR ADDRESSES
  (Chotivichit A., areesak.cho@mahidol.ac.th; Ruangchainikom M., 
monchai.ortho@gmail.com) Department of Orthopaedic Surgery, Faculty of 
Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkoknoi 
Bangkok, Thailand.
(Chiewvit P., pipat8999@yahoo.com) Department of Radiology, Faculty of 
Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkoknoi 
Bangkok, Thailand.
(Wongkajornsilp A., adisak.won@mahidol.ac.th) Department of Pharmacology, 
Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd., 
Bangkoknoi Bangkok, Thailand.
(Sujirattanawimol K., kittipong.suj@mahidol.ac.th) Department of 
Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 
Prannok Rd., Bangkoknoi Bangkok, Thailand.
CORRESPONDENCE ADDRESS
  A. Chotivichit, Department of Orthopaedic Surgery, Faculty of Medicine 
Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkoknoi Bangkok, 
Thailand. Email: areesak.cho@mahidol.ac.th
AiP/IP ENTRY DATE
  2015-05-14
FULL RECORD ENTRY DATE
  2015-05-27
SOURCE
  Journal of Medical Case Reports (2015) 9:1 Article Number: 79. Date of 
Publication: 9 Apr 2015
VOLUME
  9
ISSUE
  1
DATE OF PUBLICATION
  9 Apr 2015
ISSN
  1752-1947 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Introduction: Intrathecal transplantation is a minimally invasive method for 
the delivery of stem cells, however, whether the cells migrate from the 
lumbar to the injured cervical spinal cord has not been proved in humans. We 
describe an attempt to track bone marrow-derived mesenchymal stem cells in a 
patient with a chronic cervical spinal cord injury. Case presentation: A 
33-year-old Thai man who sustained an incomplete spinal cord injury from the 
atlanto-axial subluxation was enrolled into a pilot study aiming to track 
bone marrow-derived mesenchymal stem cells, labeled with superparamagnetic 
iron oxide nanoparticles, from intrathecal transplantation in chronic 
cervical spinal cord injury. He had been dependent on respiratory support 
since 2005. There had been no improvement in his neurological function for 
the past 54 months. Bone marrow-derived mesenchymal stem cells were 
retrieved from his iliac crest and repopulated to the target number. One 
half of the total cells were labeled with superparamagnetic iron oxide 
nanoparticles before transplantation to the intrathecal space between L4 and 
L5. Magnetic resonance imaging studies were performed immediately after the 
transplantation and at 48 hours, two weeks, one month and seven months after 
the transplantation. His magnetic resonance imaging scan performed 
immediately after the transplantation showed hyposignal intensity of 
paramagnetic substance tagged stem cells in the subarachnoid space at the 
lumbar spine area. This phenomenon was observed at the surface around his 
cervical spinal cord at 48 hours. A focal hyposignal intensity of tagged 
bone marrow-derived stem cells was detected at his cervical spinal cord with 
magnetic resonance imaging at 48 hours, which faded after two weeks, and 
then disappeared after one month. No clinical improvement of the 
neurological function had occurred at the end of this study. However, at 48 
hours after the transplantation, he presented with a fever, headache, 
myalgia and worsening of his motor function (by one grade of all key muscles 
by the American Spinal Injury Association impairment scale), which lasted 
for 48 hours. Conclusion: Intrathecal injection of bone marrow-derived stem 
cells at the lumbar spine level could deliver the cells to the injured 
cervical spinal cord. Transient complications should be observed closely in 
the first 48 hours after transplantation. Further study should be carried 
out to evaluate the result of the treatment.
EMTREE DRUG INDEX TERMS
  dexamethasone (intravenous drug administration); phosphate buffered saline; superparamagnetic iron oxide nanoparticle; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone marrow derived mesenchymal stem cell; nuclear magnetic resonance imaging; spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; article; assisted ventilation; atlantoaxial subluxation; bone marrow biopsy; case report; cauda equina; cervical spinal cord; computer assisted tomography; culture medium; fever; headache; human; iliac crest; immobilization; lumbar spine; male; mesenchymal stem cell transplantation; motor performance; myalgia; neuropathic pain; pilot study; priority journal; quadriplegia; respiratory function; subarachnoid space; tracheostomy; 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015027386
MEDLINE PMID
  25885347 (http://www.ncbi.nlm.nih.gov/pubmed/25885347)
PUI
  L604015726
DOI
  10.1186/s13256-015-0535-6
FULL TEXT LINK
  http://dx.doi.org/10.1186/s13256-015-0535-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17521947&id=doi:10.1186%2Fs13256-015-0535-6&atitle=Chronic+spinal+cord+injury+treated+with+transplanted+autologous+bone+marrow-derived+mesenchymal+stem+cells+tracked+by+magnetic+resonance+imaging%3A+A+case+report&stitle=J.+Med.+Case+Rep.&title=Journal+of+Medical+Case+Reports&volume=9&issue=1&spage=&epage=&aulast=Chotivichit&aufirst=Areesak&auinit=A.&aufull=Chotivichit+A.&coden=&isbn=&pages=-&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 341
TITLE
  Palliative care in children with spinal muscular atrophy type I: What do 
they need?
AUTHOR NAMES
  García-Salido A.; de Paso-Mora M.G.; Monleón-Luque M.; Martino-Alba R.
AUTHOR ADDRESSES
  (García-Salido A.) Pediatric Critical Care Unit and Pediatric Palliative 
Care Unit,Hospital Infantil Universitario Niño Jesús,Madrid,Spain
(de Paso-Mora M.G.) Pediatric Palliative Care Unit,Hospital Infantil 
Universitario Niño Jesús.Madrid,Spain
(Monleón-Luque M.) Pediatric Palliative Care Unit,Hospital Infantil 
Universitario Niño Jesús.Madrid,Spain
(Martino-Alba R.) Pediatric Palliative Care Unit,Hospital Infantil 
Universitario Niño Jesús.Madrid,Spain
FULL RECORD ENTRY DATE
  2016-01-26
SOURCE
  Palliative & supportive care (2015) 13:2 (313-317). Date of Publication: 1 
Apr 2015
VOLUME
  13
ISSUE
  2
FIRST PAGE
  313
LAST PAGE
  317
DATE OF PUBLICATION
  1 Apr 2015
ISSN
  1478-9523 (electronic)
ABSTRACT
  OBJECTIVE: Our aim was to describe the clinical evolution and needs of 
children with spinal muscular atrophy type I treated in a domiciliary 
palliative care program.METHOD: We undertook a retrospective chart review of 
nine consecutive patients. Descriptions of the clinical and demographic 
profile of children with spinal muscular atrophy (SMA) type I were referred 
to a pediatric palliative care team (PPCT).RESULTS: Six males and three 
females were admitted to the PPCT, all before six months of age, except for 
one afflicted with SMA type I with respiratory distress. The median time of 
attention was 57 days (range 1-150). The domiciliary attention mainly 
consisted of respiratory care. The patient with SMA type I with respiratory 
distress required domiciliary mechanical ventilation by tracheotomy. In all 
cases, a nasogastric tube (NT) was indicated. As end-of-life care, eight 
required morphine to manage the dyspnea, four received it only by enteral 
(oral or NT) administration, and four received it first by enteral 
administration with continuous subcutaneous infusion (CSI) later. Three of 
the four patients with CSI also received benzodiazepines. While they were 
attended by the PPCT, none required hospital admission. All the patients 
died at home except for the one attended to for just one day.SIGNIFICANCE OF 
RESULTS: Domiciliary care for these patients is possible. The respiratory 
morbidity and its management are the main issues. Application of an NT is 
useful to maintain nutritional balance. Morphine administration is necessary 
to manage the dyspnea. Palliative sedation is not always necessary.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  nursing; procedures; 
EMTREE MEDICAL INDEX TERMS
  female; health service; hereditary spinal muscular atrophy; human; infant; male; palliative therapy; retrospective study; terminal care; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  24565112 (http://www.ncbi.nlm.nih.gov/pubmed/24565112)
PUI
  L607858729
DOI
  10.1017/S1478951514000042
FULL TEXT LINK
  http://dx.doi.org/10.1017/S1478951514000042
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14789523&id=doi:10.1017%2FS1478951514000042&atitle=Palliative+care+in+children+with+spinal+muscular+atrophy+type+I%3A+What+do+they+need%3F&stitle=Palliat+Support+Care&title=Palliative+%26+supportive+care&volume=13&issue=2&spage=313&epage=317&aulast=Garc%C3%ADa-Salido&aufirst=Alberto&auinit=A.&aufull=Garc%C3%ADa-Salido+A.&coden=&isbn=&pages=313-317&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Medline is the source for the citation and abstract of this 
record.

RECORD 342
TITLE
  Eroding through: An uncommon cause of dysphagia
AUTHOR NAMES
  Goodwin A.K.; Moore K.M.; Rawl R.; Collins D.
AUTHOR ADDRESSES
  (Goodwin A.K.; Moore K.M.; Rawl R.; Collins D.) Carolinas Medical Center, 
Charlotte, United States.
CORRESPONDENCE ADDRESS
  A.K. Goodwin, Carolinas Medical Center, Charlotte, United States.
FULL RECORD ENTRY DATE
  2015-05-13
SOURCE
  Journal of General Internal Medicine (2015) 30 SUPPL. 2 (S392). Date of 
Publication: April 2015
VOLUME
  30
FIRST PAGE
  S392
DATE OF PUBLICATION
  April 2015
CONFERENCE NAME
  38th Annual Meeting of the Society of General Internal Medicine
CONFERENCE LOCATION
  Toronto, ON, Canada
CONFERENCE DATE
  2015-04-22 to 2015-04-25
ISSN
  0884-8734
BOOK PUBLISHER
  Springer New York LLC
ABSTRACT
  LEARNING OBJECTIVE #1: Surgically implanted cervical hardware may erode into 
the esophagus months or even years after initial implantation. LEARNING 
OBJECTIVE #2: Early diagnosis of esophageal perforation may require multiple 
diagnostic modalities with prompt surgical management crucial for minimizing 
morbidity and mortality. CASE: A 44 year-old man presented to the emergency 
department with an 8-12 month history of progressive dysphagia to solids and 
liquids, 80 lb weight loss, odynophagia, and significant dyspepsia. Review 
of systems was significant for episodic productive cough and orthopnea. 
Medical history included type 2 diabetes mellitus and a cerebral vascular 
accident 3 years prior with residual left-sided extremity motor weakness but 
no resultant speech or swallowing dysfunction. Surgical history was 
significant for remote traumatic right arm amputation and multiple cervical 
spine surgeries, with most recent anterior fixation of C3-C7 2 years prior 
for critical cervical stenosis. Physical examination showed a 
thin-appearingmale in no acute distress with stable vital signs. Neurologic 
examshowed no cranial nerve dysfunction and stable weakness in left sided 
extremities. Head and neck exam were unremarkable without palpable 
abnormality or pain on movement of the neck. Auscultation of the chest was 
remarkable for mild inspiratory stridor. Initial plain films and computed 
tomography imaging of head and neck showed surgical fixation of C3-C7 with 
anterior displacement of C6/C7 hardware and screws into the prevertebral 
soft tissue without frank intrusion in the esophagus. Barium esophagram with 
fluoroscopic evaluation showed no esophageal abnormalities. Flexible 
laryngoscopy was unremarkable for significant findings of the nasopharynx, 
hypopharynx, and larynx. Gastroenterology was consulted for upper endoscopy 
which found surgical hardware visualized at the level of the 
cricopharyngeus. Six days after presentation, the patient underwent removal 
of cervical hardware and repair of esophageal perforation with placement of 
percutaneous endoscopic gastrostomy, tracheostomy, and salivary bypass tube. 
Purulent fluid was found surrounding implanted hardware, and cultures 
isolated viridans streptococci, Candida albicans and Methicillin-resistant 
Staphylococcus aureus. He was treated with a total antibiotic course of four 
weeks with IV vancomycin and oral fluconazole. Post-operative course was 
relatively unremarkable, and after an 18 day hospitalization he was 
transferred to a rehabilitation facility. He has now returned home and 
denies dysphagia with oral intake. DISCUSSION: Anterior cervical spinal 
fixation has become a common management modality for multiple spinal 
pathologies including fracture, degenerative disc disease and neoplasm. 
Esophageal erosion and perforation by surgical hardware is uncommon with 
rates reported as low as 0.15 %. While most often occurring in the early 
post-operative phase, late-onset cases have been reported with erosion and 
perforation occurring more than 10 years after surgery. The most common 
symptoms include neck and throat pain, odynophagia, dysphagia, hoarseness, 
and aspiration. Less-common presenting symptoms include recurrent pneumonia, 
fever, cough, subcutaneous emphysema, and neurologic deficits. Our patient 
presented with progressive dysphagia, odynophagia, and weight loss with 
recurrent episodes of productive cough. Physician awareness is vital for 
identifying pertinent presenting symptoms which, in the setting of previous 
anterior cervical instrumentation, should raise concern for esophageal 
compression, erosion, and/or perforation. Prompt detection and intervention 
is crucial as mortality and complication rates rise significantly with 
delayed detection and intervention. Multiple modalities including CT 
imaging, endoscopy, and even surgical exploration may be required for 
diagnosis. In one study of patients with esophageal injury only 72.7 % were 
accurately diagnosed by imaging. Consequently, negative imaging should not 
be used as the sole means to rule out esophageal erosion or perforation. 
Esophageal perforation, as with our patient, is most common at the C5/C6 or 
C6/C7 level. Underlying causes which commonly lead to erosion include 
hardware migration, new trauma and chronic compression. Irrespective of 
cause, essential components of therapy include surgical removal of hardware, 
abscess drainage with culture-directed parental antibiotics, and salivary 
fluid diversion. Reports have noted normal swallowing function within 10-14 
days after the surgical repair. Often temporary placement of gastrostomy 
tube is warranted for nutritional support. Esophageal erosion of surgical 
hardware, though typically occurring in the early post-operative course, may 
present years later with progressive dysphagia, cough, voice changes, neck 
pain or recurrent pneumonias among some of the many presenting symptoms. 
Clinician awareness with prompt diagnosis and surgical intervention are 
crucial for minimizing morbidity and mortality.
EMTREE DRUG INDEX TERMS
  antibiotic agent; barium; fluconazole; vancomycin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia; internal medicine; society; 
EMTREE MEDICAL INDEX TERMS
  abscess drainage; alpha hemolytic Streptococcus; arm amputation; aspiration; auscultation; body weight loss; Candida albicans; cerebrovascular accident; compression; computer; computer assisted tomography; coughing; cranial nerve; devices; diagnosis; dyspepsia; early diagnosis; emergency ward; endoscopy; esophagus; esophagus injury; esophagus perforation; fever; fracture; gastroenterology; hoarseness; hospitalization; human; hypopharynx; imaging; implantation; injury; laryngoscopy; larynx; liquid; male; medical history; methicillin resistant Staphylococcus aureus; morbidity; mortality; nasopharynx; neck; neck pain; neoplasm; non insulin dependent diabetes mellitus; nutritional support; odynophagia; pain; pathology; patient; percutaneous endoscopic gastrostomy; perforation; physical examination; physician; pneumonia; rehabilitation; soft tissue; solid; sore throat; speech; spine surgery; stenosis; stomach tube; stridor; subcutaneous emphysema; surgery; swallowing; therapy; thorax; tracheostomy; tube; vital sign; voice change; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71878244
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08848734&id=doi:&atitle=Eroding+through%3A+An+uncommon+cause+of+dysphagia&stitle=J.+Gen.+Intern.+Med.&title=Journal+of+General+Internal+Medicine&volume=30&issue=&spage=S392&epage=&aulast=Goodwin&aufirst=Aaron+K.&auinit=A.K.&aufull=Goodwin+A.K.&coden=&isbn=&pages=S392-&date=2015&auinit1=A&auinitm=K
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 343
TITLE
  What are the perspectives for ventilated tetraplegics? A French 
retrospective study of 108 patients with cervical spinal cord injury
AUTHOR NAMES
  Quesnel A.; Veber B.; Proust F.; Agasse E.; Beuret Blanquart F.; Verin E.
AUTHOR ADDRESSES
  (Quesnel A.; Beuret Blanquart F.; Verin E., eric.verin@chu-rouen.fr) CRMPR 
Les Herbiers, 111, rue Herbeuse, Bois Guillaume, France.
(Veber B.) Service de réanimation chirurgicale, CHU de Rouen, 1, rue de 
Germont, Rouen cedex, France.
(Proust F.) Service de neurochirurgie, CHU de Rouen, 1, rue de Germont, 
Rouen cedex, France.
(Agasse E.) Centre Jacques-Calvé, 72, Esplanade Parmentier, Berck-sur-Mer 
cedex, France.
(Verin E., eric.verin@chu-rouen.fr) Pôle 3R, CHU de Rouen, 1, rue de 
Germont, Rouen cedex, France.
(Verin E., eric.verin@chu-rouen.fr) EA 3830, Groupe de recherche sur le 
handicap ventilatoire (GRHV), Université de Rouen, Rouen, France.
CORRESPONDENCE ADDRESS
  E. Verin, Pôle 3R, CHU de Rouen, 1, rue de Germont, Rouen cedex, France. 
Email: eric.verin@chu-rouen.fr
AiP/IP ENTRY DATE
  2015-03-13
FULL RECORD ENTRY DATE
  2016-01-07
SOURCE
  Annals of Physical and Rehabilitation Medicine (2015) 58:2 (74-77). Date of 
Publication: 1 Apr 2015
VOLUME
  58
ISSUE
  2
FIRST PAGE
  74
LAST PAGE
  77
DATE OF PUBLICATION
  1 Apr 2015
ISSN
  1877-0665 (electronic)
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex, 
France.
ABSTRACT
  Objective: Tetraplegic patients are often difficult to manage in intensive 
care units (ICU). The aim of our study was to calculate the incidence of 
patients in ICU with cervical spinal cord injury with special focus on 
tetraplegic patients on ventilation support and their future perspectives. 
Materials and methods: This retrospective study included patients with 
cervical spinal cord injury in Upper Normandy, between 2002 and 2012. Data 
analyzed included age, sex, past medical history, date of onset of 
quadriplegia, level of neurological involvement, AIS grade, and ventilatory 
status. Results: One hundred and eight patients were included (49.0 ± 21.1 
years). The most common etiology was fall (50 patients [46.3%]). Incidence 
was calculated at 12.7 per one million inhabitants. Tracheotomy was 
performed in 40.7% of patients. Long-term mechanical ventilation was 
required for 6.5%. At the end of the study, 9 patients (9.6%) were 
permanently hospitalized, 61 patients (64.9%) had returned home but none of 
the four ventilated patients had been discharged. Conclusion: The conclusion 
of this work is that the future of highly tetraplegic patients is 
compromised, especially for those who remain reliant on mechanical 
ventilation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury (etiology); quadriplegia (etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; article; falling; female; home care; hospital patient; human; intensive care unit; long term care; major clinical study; male; outcome assessment; retrospective study; sport injury; tracheotomy; traffic accident; ventilated patient; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015809470
MEDLINE PMID
  25766088 (http://www.ncbi.nlm.nih.gov/pubmed/25766088)
PUI
  L602829186
DOI
  10.1016/j.rehab.2014.12.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2014.12.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770665&id=doi:10.1016%2Fj.rehab.2014.12.004&atitle=What+are+the+perspectives+for+ventilated+tetraplegics%3F+A+French+retrospective+study+of+108+patients+with+cervical+spinal+cord+injury&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=58&issue=2&spage=74&epage=77&aulast=Quesnel&aufirst=A.&auinit=A.&aufull=Quesnel+A.&coden=&isbn=&pages=74-77&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 344
TITLE
  Radiotherapy QA of the DAHANCA 19 protocol
AUTHOR NAMES
  Samsøe E.; Andersen E.; Hansen C.R.; Johansen J.; Sand H.M.B.; Andersen L.J.; Petersen J.B.B.; Jensen K.; Smulders B.; Kristensen C.A.; Grau C.
AUTHOR ADDRESSES
  (Samsøe E.; Andersen E.) University Hospital Herlev, Department of Oncology, 
Herlev, Denmark.
(Hansen C.R.) Odense University Hospital, Laboratory of Radiation Physics, 
Odense, Denmark.
(Johansen J.) Odense University Hospital, Department of Oncology, Odense, 
Denmark.
(Sand H.M.B.; Andersen L.J.) Aalborg Sygehus, Department of Oncology, 
Aalborg, Denmark.
(Petersen J.B.B.) Aarhus University Hospital, Department of Medical Physics, 
Aarhus, Denmark.
(Jensen K.; Grau C.) Aarhus University Hospital, Department of Oncology, 
Aarhus, Denmark.
(Smulders B.; Kristensen C.A.) Copenhagen University Hospital, Department of 
Oncology, Copenhagen, Denmark.
CORRESPONDENCE ADDRESS
  E. Samsøe, University Hospital Herlev, Department of Oncology, Herlev, 
Denmark.
FULL RECORD ENTRY DATE
  2015-07-31
SOURCE
  Radiotherapy and Oncology (2015) 115 SUPPL. 1 (S494-S495). Date of 
Publication: April 2015
VOLUME
  115
FIRST PAGE
  S494
LAST PAGE
  S495
DATE OF PUBLICATION
  April 2015
CONFERENCE NAME
  3 ESTRO Forum
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2015-04-24 to 2015-04-28
ISSN
  0167-8140
BOOK PUBLISHER
  Elsevier Ireland Ltd
ABSTRACT
  Purpose/Objective: It has been demonstrated that nonadherence to 
protocol-specified radiotherapy (RT) requirements is associated with reduced 
survival, local control and potentially increased toxicity [1]. Thus, 
quality assurance (QA) of RT is important when evaluating the results of 
clinical trials. RT-QA of large multicentre-trials, however, requires 
substantial effort and resources. Recently, we presented a digital QA 
platform, the CIRRO dose plan bank, which allows for central review of such 
trials. Here, we present our RT-QA results from the latest completed 
clinical protocol from the Danish Head and Neck Cancer Group (DAHANCA). 
Materials and Methods: The clinical results of the DAHANCA 19 randomized 
phase III trial evaluated the effect of concurrent EGFR-inhibition during 
primary curative (chemo) radiotherapy in patients with head and neck 
squamous cell carcinoma (HNSCC). A total of 504 Danish patients entered the 
protocol in 2007-2012. Patients received RT at 5 different oncology centers 
to a total dose of 66-68Gy, 2Gy/fx, 6 fx/week. For the current QA analysis, 
total treatment time, CTV coverage, and near-max doses to the spinal cord 
and brainstem including the corresponding planning risk volumes (PRVs) were 
evaluated according to 2004 DAHANCA guidelines. Each QA parameter was scored 
within three categories: 1) Full compliance to protocol guidelines, 2) Minor 
deviations: Not according to guidelines, but without clinical relevance, and 
3) Major deviations: Clinical significant deviation. Categories 1) and 2) 
are clinical acceptable, whereas category 3) is clinical unacceptable. 
Results: The complete digital RT dataset was uploaded for all 504 patients 
and QA parameters were extracted. The results are shown in table 1. Not all 
patients contribute to the PRV data, since the PRV concept was introduced in 
the Danish clinics shortly after 2007. Furthermore, 13 patients (2.6%) were 
eliminated from the CTV QA due to challenges to extract dose summations 
(e.g. re-scans and primary/ boost dose plans) from the database. A total of 
11 major deviations were recorded. Four major deviations in CTV1 dose 
coverage were due to clinical considerations of the tolerance dose to the 
spinal cord, thus compromising target dose. Five of the major deviations in 
total treatment time were related to comorbidities, such as alcohol- or 
cardiac related matters and hospitalization. The remaining two cases were 
due to tracheotomy procedures and subsequent re-scans, which delayed the RT 
course. Table 1: Summary of results from RT-QA of the DAHANCA protocol. 
Conclusions: RT dose plans in DAHANCA 19 adhere well to national clinical 
guidelines. A total of 11 major deviations were found in 504 patients. All 
majors were clinically well accounted for.
EMTREE DRUG INDEX TERMS
  alcohol; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  radiotherapy; 
EMTREE MEDICAL INDEX TERMS
  brain stem; clinical protocol; clinical trial (topic); data base; head and neck cancer; head and neck squamous cell carcinoma; hospital; hospitalization; human; multicenter study; oncology; parameters; patient; planning; procedures; protocol compliance; quality control; risk; spinal cord; survival; toxicity; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71961484
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01678140&id=doi:&atitle=Radiotherapy+QA+of+the+DAHANCA+19+protocol&stitle=Radiother.+Oncol.&title=Radiotherapy+and+Oncology&volume=115&issue=&spage=S494&epage=S495&aulast=Sams%C3%B8e&aufirst=E.&auinit=E.&aufull=Sams%C3%B8e+E.&coden=&isbn=&pages=S494-S495&date=2015&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 345
TITLE
  Unmasking and provoking severe disease activity in a patient with NMO 
spectrum disorder
AUTHOR NAMES
  Kornberg M.D.; Newsome S.D.
AUTHOR ADDRESSES
  (Kornberg M.D.; Newsome S.D., snewsom2@jhmi.edu) Department of Neurology, 
Johns Hopkins University, Baltimore, United States.
CORRESPONDENCE ADDRESS
  S.D. Newsome, Department of Neurology, Johns Hopkins University, Baltimore, 
United States. Email: snewsom2@jhmi.edu
AiP/IP ENTRY DATE
  2016-09-30
FULL RECORD ENTRY DATE
  2016-10-12
SOURCE
  Neurology: Neuroimmunology and NeuroInflammation (2015) 2:2 (e66). Date of 
Publication: 1 Apr 2015
VOLUME
  2
ISSUE
  2
FIRST PAGE
  e66
DATE OF PUBLICATION
  1 Apr 2015
ISSN
  2332-7812 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
EMTREE DRUG INDEX TERMS
  aquaporin 4 antibody (endogenous compound); fingolimod (drug therapy); methylprednisolone (drug therapy, intravenous drug administration); natalizumab (adverse drug reaction, drug therapy); rituximab (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  disease severity; multiple sclerosis (drug therapy, diagnosis, drug therapy); myelooptic neuropathy (side effect, diagnosis, side effect, therapy); myelooptic neuropathy (side effect, diagnosis, side effect, therapy); relapse; 
EMTREE MEDICAL INDEX TERMS
  adult; brain biopsy; case report; cervical spinal cord injury; corticosteroid therapy; drug substitution; drug withdrawal; dysarthria (side effect); dysphagia (side effect); enzyme linked immunosorbent assay; female; follow up; human; human tissue; immunotherapy; lack of drug effect; middle cerebellar peduncle; neuroimaging; note; nuclear magnetic resonance imaging; paraplegia; patient transport; plasma exchange; priority journal; quadriplegia (side effect); repeat procedure; respiratory tract intubation; speech disorder; stomach intubation; stomach tube; tracheostomy; trismus; white matter lesion; 
CAS REGISTRY NUMBERS
  fingolimod (162359-56-0)
  methylprednisolone (6923-42-8, 83-43-2)
  natalizumab (189261-10-7)
  rituximab (174722-31-7)
EMBASE CLASSIFICATIONS
  Ophthalmology (12)
  Radiology (14)
  Immunology, Serology and Transplantation (26)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160690970
PUI
  L612266542
DOI
  10.1212/NXI.0000000000000066
FULL TEXT LINK
  http://dx.doi.org/10.1212/NXI.0000000000000066
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23327812&id=doi:10.1212%2FNXI.0000000000000066&atitle=Unmasking+and+provoking+severe+disease+activity+in+a+patient+with+NMO+spectrum+disorder&stitle=Neurol.+Neuroimmunol.+Neuroinflamm.&title=Neurology%3A+Neuroimmunology+and+NeuroInflammation&volume=2&issue=2&spage=e66&epage=&aulast=Kornberg&aufirst=Michael+D.&auinit=M.D.&aufull=Kornberg+M.D.&coden=&isbn=&pages=e66-&date=2015&auinit1=M&auinitm=D
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 346
TITLE
  Global health care use by patients with type-2 diabetes: Does the type of 
comorbidity matter?
AUTHOR NAMES
  Calderón-Larrañaga A.; Abad-Díez J.M.; Gimeno-Feliu L.A.; Marta-Moreno J.; González-Rubio F.; Clerencia-Sierra M.; Poblador-Plou B.; Poncel-Falcó A.; Prados-Torres A.
AUTHOR ADDRESSES
  (Calderón-Larrañaga A., acalderon.iacs@aragon.es; Abad-Díez J.M.; 
Gimeno-Feliu L.A.; Marta-Moreno J.; González-Rubio F.; Clerencia-Sierra M.; 
Poblador-Plou B.; Poncel-Falcó A.; Prados-Torres A.) EpiChron Research Group 
on Chronic Diseases, Aragon Health Sciences Institute (IACS), IIS Aragon, 
Miguel Servet University Hospital, Paseo Isabel La Católica 1-3, Zaragoza, 
Spain.
(Abad-Díez J.M.) Dept. of Health,Welfare and Family, DG Planning and 
Assurance, Government of Aragon, Vía Univérsitas 36, Zaragoza, Spain.
(Gimeno-Feliu L.A.) San Pablo Health Centre, Aragon Health Service (SALUD), 
C/Aguadores 7, Zaragoza, Spain.
(Marta-Moreno J.) Miguel Servet University Hospital, Department of 
Neurology, Aragon Health Service (SALUD), Paseo Isabel La Católica 1-3, 
Zaragoza, Spain.
(González-Rubio F.) Delicias sur Health Centre, Aragon Health Service 
(SALUD), C/Manuel Dronda 1, Zaragoza, Spain.
(Clerencia-Sierra M.) Socio-Sanitary Assessment Unit, Miguel Servet 
University Hospital, Aragon Health Service (SALUD), Paseo Isabel La Católica 
1-3, Zaragoza, Spain.
(Poncel-Falcó A.) Zaragoza-Sector III Primary Care Directorate, Aragon 
Health Service (SALUD), C/Condes de Aragón 30, Zaragoza, Spain.
CORRESPONDENCE ADDRESS
  A. Calderón-Larrañaga, EpiChron Research Group on Chronic Diseases, Aragon 
Health Sciences Institute (IACS), IIS Aragon, Miguel Servet University 
Hospital, Paseo Isabel La Católica 1-3, Zaragoza, Spain. Email: 
acalderon.iacs@aragon.es
AiP/IP ENTRY DATE
  2015-03-17
FULL RECORD ENTRY DATE
  2015-04-21
SOURCE
  European Journal of Internal Medicine (2015) 26:3 (203-210). Date of 
Publication: 1 Apr 2015
VOLUME
  26
ISSUE
  3
FIRST PAGE
  203
LAST PAGE
  210
DATE OF PUBLICATION
  1 Apr 2015
ISSN
  1879-0828 (electronic)
  0953-6205
BOOK PUBLISHER
  Elsevier
ABSTRACT
  To identify patterns of health care use among diabetic patients with 
multimorbidity across primary, specialised, hospital and emergency care, 
depending on their type of chronic comorbidity. Methods Longitudinal study 
of a population-based retrospective cohort conformed by adult patients with 
type-2 diabetes assigned to any of the primary care centres in Aragon during 
2010 and 2011 (n = 65,716). Negative binomial regressions were run to model 
the effect of the type of comorbidity on the number of visits to each level 
of care. Comorbidities were classified as concordant, discordant or mental 
based on expert consensus and depending on whether they shared the same 
overall pathophysiologic risk profile and disease management plan designed 
for type-2 diabetes. Results Mental comorbidity was independently associated 
with total and unplanned admissions (incidence rate ratio [IRR]:1.25; 95% 
confidence interval [CI]:1.12-1.39, IRR:1.21; 95% CI:1.06-1.39), average 
length of stay (IRR:1.47; 95% CI:1.25-1.73), and total and priority 
emergency room visits (IRR:1.26; 95% CI:1.17-1.35, IRR:1.30; 95% 
CI:1.18-1.42). Patients with discordant comorbidities showed the strongest 
associations with the number of visits to specialists (IRR:1.38; 95% 
CI:1.33-1.43) and to different specialties (IRR:1.36; 95% CI:1.32-1.39). 
Differences regarding GP visits were lower but still significant for 
patients with discordant comorbidity (IRR:1.08; 95% CI:1.06-1.11), but 
especially for those with mental comorbidity (IRR:1.17; 95% CI:1.14-1.21). 
Conclusion In patients with type-2 diabetes, the coexistence of mental 
comorbidity significantly increases the use of unplanned hospital services, 
and discordant comorbidities have an important effect on specialised care 
use. Differences with respect to primary care use are not as prominent.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health care utilization; non insulin dependent diabetes mellitus; 
EMTREE MEDICAL INDEX TERMS
  acquired immune deficiency syndrome; acute heart infarction; acute leukemia; adult; affective psychosis; anxiety disorder; aortic aneurysm; aphakia; aplastic anemia; arthropathy; article; asthma; atherosclerosis; attention deficit disorder; autoimmune disease; behavior disorder; bladder cancer; blindness; blood clotting disorder; breast cancer; cardiomyopathy; cardiovascular disease; cataract; cerebral palsy; cerebrovascular disease; chromosome aberration; chronic kidney failure; chronic liver disease; chronic obstructive lung disease; chronic pancreatitis; cleft lip; clinical assessment; colorectal cancer; comorbidity; congenital heart disease; congenital hip dislocation; congenital malformation; congestive heart failure; connective tissue disease; cystic fibrosis; deep vein thrombosis; delirium; dementia; depression; dermatitis; developmental disorder; diabetic patient; diabetic retinopathy; disorders of lipid metabolism; diverticulosis; eczema; emergency ward; emphysema; endocrine disease; endometriosis; esophagus cancer; female; gallstone formation; gastroesophageal reflux; glaucoma; gout; hair disease; hearing impairment; heart arrhythmia; hematologic disease; hemolytic anemia; hemophilia; hospital service; human; Human immunodeficiency virus infection; hypertension; hypospadias; hypothyroidism; immunopathology; iron deficiency anemia; irritable colon; ischemic heart disease; kidney disease; kyphoscoliosis; lactose intolerance; leg varicosis; length of stay; longitudinal study; low back pain; lung embolism; lymphoma; major clinical study; male; malignant neoplasm; medical specialist; metabolic disorder; multiple sclerosis; muscular dystrophy; nephritis; neuritis; neurologic disease; neurosis; obesity; organ transplantation; osteoarthritis; osteoporosis; ovary cancer; paralysis; Parkinson disease; peripheral neuropathy; peripheral vascular disease; personality disorder; primary medical care; prostate hypertrophy; prostatitis; psoriasis; quadriplegia; respiratory tract disease; retina disease; schizophrenia; seizure; skin cancer; skin ulcer; sleep disordered breathing; spinal cord injury; stomach cancer; substance use; thrombophlebitis; tracheostomy; tuberculosis; uterus prolapse; valvular heart disease; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015819494
MEDLINE PMID
  25765442 (http://www.ncbi.nlm.nih.gov/pubmed/25765442)
PUI
  L602903213
DOI
  10.1016/j.ejim.2015.02.011
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ejim.2015.02.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18790828&id=doi:10.1016%2Fj.ejim.2015.02.011&atitle=Global+health+care+use+by+patients+with+type-2+diabetes%3A+Does+the+type+of+comorbidity+matter%3F&stitle=Eur.+J.+Intern.+Med.&title=European+Journal+of+Internal+Medicine&volume=26&issue=3&spage=203&epage=210&aulast=Calder%C3%B3n-Larra%C3%B1aga&aufirst=A.&auinit=A.&aufull=Calder%C3%B3n-Larra%C3%B1aga+A.&coden=EJIME&isbn=&pages=203-210&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 347
TITLE
  Course of near-hanging victims succumbed to death: A seven year study
AUTHOR NAMES
  Ramchandra Sane M.; Mugadlimath A.B.; Zine K.U.; Farooqui J.M.; Phalke B.J.
AUTHOR ADDRESSES
  (Ramchandra Sane M., drmrsane@gmail.com; Zine K.U.; Phalke B.J.) Department 
of Forensic Medicine, Government Medical College, Aurangabad, India.
(Mugadlimath A.B.) Department of Forensic Medicine, Ashwini Rural Medical 
College, Solapur, India.
(Farooqui J.M.) Department of Forensic Medicine, Rural Medical College 
Pravara Institute of Medical Sciences Loni, Tal-Rahata, Aurangabad, India.
CORRESPONDENCE ADDRESS
  M. Ramchandra Sane, Department of Forensic Medicine, Government Medical 
College, Aurangabad, India.
AiP/IP ENTRY DATE
  2015-03-09
FULL RECORD ENTRY DATE
  2015-03-12
SOURCE
  Journal of Clinical and Diagnostic Research (2015) 9:3 (HC01-HC03). Date of 
Publication: 1 Mar 2015
VOLUME
  9
ISSUE
  3
FIRST PAGE
  HC01
LAST PAGE
  HC03
DATE OF PUBLICATION
  1 Mar 2015
ISSN
  0973-709X (electronic)
  2249-782X
BOOK PUBLISHER
  Journal of Clinical and Diagnostic Research, No 3, 1/9 Roop Nagar,, G T 
Road, Delhi, India. editor-in-chief@jcdr.net
ABSTRACT
  Introduction: Near hanging refers to victims who survive a hanging injury 
following attempted hanging, long enough to reach hospital. Delayed deaths 
in near hanging patients are mostly due to complication of hanging. The 
purpose of this study was to evaluate the demographics, mortality patterns 
and cause of delayed deaths in near hanging victims. Materials and Methods: 
In this study autopsy files over a seven year period from 2007 to 2013 were 
reviewed, and data of near hanging deaths (attempted hanging cases who 
succumbed to death and subjected for medicolegal autopsy) was extracted. 
Records of 14,000 autopsies was reviewed, and 10 deceased having died 
delayed deaths after near hanging episode were identified. In each case, the 
patients’ details, including gender, age, type of suspension, type of 
ligature material used for hanging and subsequent hanging mark produced were 
reviewed using autopsy reports and photographs taken during autopsy. 
Results: Demographic and pathological aspects of the each case discussed to 
throw light on autopsy findings in victims who died following near hanging. 
Complete suspension was present in 3 cases, while partial suspension was 
present in 7 cases. Survivals in delayed death after near hanging episode 
have ranged from 9 h to 72 d. Hypoxic encephalopathy was the most common 
cause of death, followed by pneumonia. Conclusion: Most of the near hanging 
patients did succumb to hypoxic encephalopathy; however, consolidation of 
lungs (pneumonia) was the next common cause of death reflecting need for 
aggressive oxygen therapy and selective resuscitation should be performed in 
all such cases.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  death; delayed death; hanging; near hanging; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; autopsy; cause of death; cervical spinal cord injury; demography; female; human; male; mortality; pathology; pneumonia; resuscitation; retrospective study; tracheostomy; young adult; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015791851
PUI
  L602542427
DOI
  10.7860/JCDR/2015/11189.5647
FULL TEXT LINK
  http://dx.doi.org/10.7860/JCDR/2015/11189.5647
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0973709X&id=doi:10.7860%2FJCDR%2F2015%2F11189.5647&atitle=Course+of+near-hanging+victims+succumbed+to+death%3A+A+seven+year+study&stitle=J.+Clin.+Diagn.+Res.&title=Journal+of+Clinical+and+Diagnostic+Research&volume=9&issue=3&spage=HC01&epage=HC03&aulast=Ramchandra+Sane&aufirst=Mandar&auinit=M.&aufull=Ramchandra+Sane+M.&coden=&isbn=&pages=HC01-HC03&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 348
TITLE
  A study of the clinical and radiological features in a cohort of 93 patients 
with a COL2A1 mutation causing spondyloepiphyseal dysplasia congenita or a 
related phenotype
AUTHOR NAMES
  Terhal P.A.; Nievelstein R.J.A.J.; Verver E.J.J.; Topsakal V.; van Dommelen P.; Hoornaert K.; Le Merrer M.; Zankl A.; Simon M.E.H.; Smithson S.F.; Marcelis C.; Kerr B.; Clayton-Smith J.; Kinning E.; Mansour S.; Elmslie F.; Goodwin L.; van der Hout A.H.; Veenstra-Knol H.E.; Herkert J.C.; Lund A.M.; Hennekam R.C.M.; Mégarbané A.; Lees M.M.; Wilson L.C.; Male A.; Hurst J.; Alanay Y.; Annerén G.; Betz R.C.; Bongers E.M.H.F.; Cormier-Daire V.; Dieux A.; David A.; Elting M.W.; van den Ende J.; Green A.; van Hagen J.M.; Hertel N.T.; Holder-Espinasse M.; den Hollander N.; Homfray T.; Hove H.D.; Price S.; Raas-Rothschild A.; Rohrbach M.; Schroeter B.; Suri M.; Thompson E.M.; Tobias E.S.; Toutain A.; Vreeburg M.; Wakeling E.; Knoers N.V.; Coucke P.; Mortier G.R.
AUTHOR ADDRESSES
  (Terhal P.A., p.a.terhal@umcutrecht.nl; Knoers N.V.) Department of Medical 
Genetics, University Medical Centre Utrecht, Utrecht, Netherlands.
(Nievelstein R.J.A.J.) Department of Radiology, University Medical Centre 
Utrecht, Utrecht, Netherlands.
(Verver E.J.J.; Topsakal V.) Department of Otorhinolaryngology and Head and 
Neck Surgery, Rudolf Magnus Institute of Neuroscience, University Medical 
Centre Utrecht, Utrecht, Netherlands.
(van Dommelen P.) Department of Life Style, TNO, Leiden, Netherlands.
(Hoornaert K.) Department of Ophthalmology, University Hospital Ghent, 
Ghent, Belgium.
(Le Merrer M.; Cormier-Daire V.) Department of Genetics, INSERM UMR-1163, 
Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Hôpital 
Necker-Enfants Malades, Paris, France.
(Zankl A.) Academic Department of Medical Genetics, Discipline of Genetic 
Medicine, The University of Sydney, Sydney Children's Hospital Network 
(Westmead), Sydney, Australia.
(Simon M.E.H.) Department of Clinical Genetics, Erasmus Medical Centre, 
University Medical Centre, Rotterdam, Netherlands.
(Smithson S.F.) Department of Clinical Genetics, St. Michael's Hospital, 
Bristol, United Kingdom.
(Marcelis C.; Bongers E.M.H.F.) Department of Human Genetics, Nijmegen 
Centre for Molecular Life Sciences, Institute for Genetic and Metabolic 
Disease, Radboud University Medical Centre, Nijmegen, Netherlands.
(Kerr B.; Clayton-Smith J.) Manchester Centre For Genomic Medicine, 
University of Manchester, St Mary's Hospital, Manchester, United Kingdom.
(Kinning E.) Department of Clinical Genetics, Southern General Hospital, 
Glasgow, United Kingdom.
(Mansour S.; Elmslie F.) SW Thames Regional Genetics Service, St George's 
NHS Trust, London, United Kingdom.
(Goodwin L.) Department of Genetics, Nepean Hospital, Penrith, Australia.
(van der Hout A.H.; Veenstra-Knol H.E.; Herkert J.C.) Department of 
Genetics, University Medical Centre Groningen, Groningen, Netherlands.
(Lund A.M.) Centre for Inherited Metabolic Diseases, Department of Clinical 
Genetics, Copenhagen University Hospital, Copenhagen, Denmark.
(Hennekam R.C.M.) Department of Pediatrics, Academic Medical Centre, 
University of Amsterdam, Amsterdam, Netherlands.
(Mégarbané A.) Unité de Génétique Médicale et Laboratoire Associé, Institut 
National de la Santé et de la Recherche Médicale UMR-S910, Université 
Saint-Joseph, Beirut, Lebanon.
(Lees M.M.; Wilson L.C.; Male A.; Hurst J.) Department of Clinical Genetics, 
Great Ormond Street Hospital, London, United Kingdom.
(Hurst J.; Price S.) Department of Clinical Genetics, Churchill Hospital, 
Oxford, United Kingdom.
(Alanay Y.) Pediatric Genetics Unit, Department of Pediatrics, Acibadem 
University School of Medicine, Istanbul, Turkey.
(Annerén G.) Department of Immunology, Genetics and Pathology, Science for 
Life Laboratory, Uppsala University, Uppsala, Sweden.
(Betz R.C.) Institute of Human Genetics, University of Bonn, Bonn, Germany.
(Dieux A.; Holder-Espinasse M.) Service de Génétique Clinique, Hôpital 
Jeanne de Flandre, Lille, France.
(David A.) Service de Génétique Médicale, CHU de Nantes, Nantes, France.
(Elting M.W.; van Hagen J.M.) Department of Clinical Genetics, VU University 
Medical Centre, Amsterdam, Netherlands.
(van den Ende J.; Mortier G.R.) Department of Medical Genetics, Antwerp 
University Hospital, University of Antwerp, Edegem, Belgium.
(Green A.) National Centre for Medical Genetics and School of Medicine and 
Medical Science, University College Dublin, Our Lady's Hospital Crumlin, 
Dublin, Ireland.
(Hertel N.T.) H.C. Andersen Children's Hospital, Odense University Hospital, 
Odense, Denmark.
(Holder-Espinasse M.) Department of Clinical Genetics, Guy's Hospital, 
London, United Kingdom.
(den Hollander N.) Department of Clinical Genetics, Leiden University 
Medical Centre, Leiden, Netherlands.
(Hove H.D.) Department of Clinical Genetics, Rigshospitalet, Copenhagen, 
Denmark.
(Raas-Rothschild A.) Institute of Medical Genetics, Meir Medical Centre, 
Kfar Saba, Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel.
(Rohrbach M.) Division of Metabolism, Children's Research Centre, Connective 
Tissue Unit, University Children's Hospital Zurich, Zurich, Switzerland.
(Schroeter B.) Kinderspital Luzern, Luzern, Switzerland.
(Suri M.) Nottingham Clinical Genetics Service, City Hospital Campus, 
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
(Thompson E.M.) SA Clinical Genetics, SA Pathology at the Women's and 
Children's Hospital, North Adelaide, Australia.
(Tobias E.S.) Medical Genetics, School of Medicine, Coll Med Vet and Life 
Sci, University of Glasgow, Glasgow, Scotland, United Kingdom.
(Toutain A.) Service de Génétique, Hôpital Bretonneau, Tours, France.
(Vreeburg M.) Department of Clinical Genetics, Maastricht University Medical 
Centre, Maastricht, Netherlands.
(Wakeling E.) North West Thames Regional Genetic Service, North West London 
Hospitals NHS Trust, London, United Kingdom.
(Coucke P.) Department of Medical Genetics, Ghent University Hospital, 
Ghent, Belgium.
(Homfray T.; Coucke P.; Mortier G.R.) Ghent University, Ghent, Belgium.
(Thompson E.M.) Department of Paediatrics, University of Adelaide, Adelaide, 
North Terrace, Australia.
CORRESPONDENCE ADDRESS
  P.A. Terhal, Department of Medical Genetics, Division of Biomedical 
Genetics, University Medical Centre Utrecht, Lundlaan 6, Utrecht, 
Netherlands. Email: p.a.terhal@umcutrecht.nl
AiP/IP ENTRY DATE
  2015-02-25
FULL RECORD ENTRY DATE
  2015-02-27
SOURCE
  American Journal of Medical Genetics, Part A (2015) 167:3 (461-475). Date of 
Publication: 1 Mar 2015
VOLUME
  167
ISSUE
  3
FIRST PAGE
  461
LAST PAGE
  475
DATE OF PUBLICATION
  1 Mar 2015
ISSN
  1552-4833 (electronic)
  1552-4825
BOOK PUBLISHER
  Wiley-Liss Inc., info@wiley.com
ABSTRACT
  Type 2 collagen disorders encompass a diverse group of skeletal dysplasias 
that are commonly associated with orthopedic, ocular, and hearing problems. 
However, the frequency of many clinical features has never been determined. 
We retrospectively investigated the clinical, radiological, and genotypic 
data in a group of 93 patients with molecularly confirmed SEDC or a related 
disorder. The majority of the patients (80/93) had short stature, with 
radiological features of SEDC (n=64), others having SEMD (n=5), Kniest 
dysplasia (n=7), spondyloperipheral dysplasia (n=2), or Torrance-like 
dysplasia (n=2). The remaining 13 patients had normal stature with mild SED, 
Stickler-like syndrome or multiple epiphyseal dysplasia. Over 50% of the 
patients had undergone orthopedic surgery, usually for scoliosis, femoral 
osteotomy or hip replacement. Odontoid hypoplasia was present in 56% (95% CI 
38-74) and a correlation between odontoid hypoplasia and short stature was 
observed. Atlanto-axial instability, was observed in 5 of the 18 patients 
(28%, 95% CI 10-54) in whom flexion-extension films of the cervical spine 
were available; however, it was rarely accompanied by myelopathy. Myopia was 
found in 45% (95% CI 35-56), and retinal detachment had occurred in 12% (95% 
CI 6-21; median age 14 years; youngest age 3.5 years). Thirty-two patients 
complained of hearing loss (37%, 95% CI 27-48) of whom 17 required hearing 
aids. The ophthalmological features and possibly also hearing loss are often 
relatively frequent and severe in patients with splicing mutations. Based on 
clinical findings, age at onset and genotype-phenotype correlations in this 
cohort, we propose guidelines for the management and follow-up in this group 
of disorders.
EMTREE DRUG INDEX TERMS
  aspartic acid (endogenous compound); glycine (endogenous compound); procollagen (endogenous compound); serine (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  COL2A1 gene; gene; gene mutation; spondyloepiphyseal dysplasia (congenital disorder); 
EMTREE MEDICAL INDEX TERMS
  adolescent; amino acid substitution; article; atlantoaxial dislocation; bronchomalacia; child; cleft palate; clinical feature; clubfoot (surgery); coxa vara; disease severity; female; genotype phenotype correlation; gestational age; hearing impairment; heterozygosity; hip arthroplasty; human; hypermetropia; major clinical study; male; missense mutation; mutational analysis; myopia; osteotomy; Pierre Robin syndrome; population research; respiratory distress; retina detachment; school child; scoliosis (surgery); tracheomalacia; tracheostomy; 
CAS REGISTRY NUMBERS
  aspartic acid (56-84-8, 6899-03-2)
  glycine (56-40-6, 6000-43-7, 6000-44-8)
  serine (56-45-1, 6898-95-9)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015760508
MEDLINE PMID
  25604898 (http://www.ncbi.nlm.nih.gov/pubmed/25604898)
PUI
  L602418404
DOI
  10.1002/ajmg.a.36922
FULL TEXT LINK
  http://dx.doi.org/10.1002/ajmg.a.36922
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15524833&id=doi:10.1002%2Fajmg.a.36922&atitle=A+study+of+the+clinical+and+radiological+features+in+a+cohort+of+93+patients+with+a+COL2A1+mutation+causing+spondyloepiphyseal+dysplasia+congenita+or+a+related+phenotype&stitle=Am.+J.+Med.+Genet.+Part+A&title=American+Journal+of+Medical+Genetics%2C+Part+A&volume=167&issue=3&spage=461&epage=475&aulast=Terhal&aufirst=Paulien+A.&auinit=P.A.&aufull=Terhal+P.A.&coden=AJMGD&isbn=&pages=461-475&date=2015&auinit1=P&auinitm=A
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 349
TITLE
  Complications and survival after long posterior instrumentation of cervical 
and cervicothoracic fractures related to ankylosing spondylitis or diffuse 
idiopathic skeletal hyperostosis
AUTHOR NAMES
  Robinson Y.; Robinson A.-L.; Olerud C.
AUTHOR ADDRESSES
  (Robinson Y., yohan.robinson@surgsci.uu.se; Robinson A.-L.; Olerud C.) 
Department of Surgical Sciences, Uppsala University Hospital, Uppsala, 
Sweden.
CORRESPONDENCE ADDRESS
  Y. Robinson, Department of Surgical Sciences, Uppsala University Hospital, 
Uppsala, Sweden. Email: yohan.robinson@surgsci.uu.se
AiP/IP ENTRY DATE
  2014-12-19
FULL RECORD ENTRY DATE
  2016-10-14
SOURCE
  Spine (2015) 40:4 (E227-E233). Date of Publication: 15 Feb 2015
VOLUME
  40
ISSUE
  4
FIRST PAGE
  E227
LAST PAGE
  E233
DATE OF PUBLICATION
  15 Feb 2015
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, kathiest.clai@apta.org
ABSTRACT
  Objective. This study investigates the results of long posterior 
instrumentation with regard to complications and survival. Summary of 
Background Data. Fractures of the cervical spine and the cervicothoracic 
junction related to ankylosing spinal disease (ASD) endanger both sagittal 
profi le and spinal cord. Both anterior and posterior stabilization methods 
are well established, and clear treatment guidelines are missing. Methods. 
Forty-one consecutive patients with fractures of the cervicothoracic 
junction related to ASD were treated by posterior instrumentation. All 
patients were followed prospectively for 2 years using a standardized 
protocol. Results. Five patients experienced postoperative infections, 3 
patients experienced postoperative pneumonia, 2 patients required 
postoperative tracheostomy, and 1 patient had postoperative cerebrospinal fl 
uid leakage due to accidental durotomy. No patient required reoperation due 
to implant failure or nonunion. Mean survival was 52 months (95% confi dence 
interval: 42-62 mo). Survival was affected by patient age, sex, smoking, and 
spinal cord injury. Conclusion. Patients with ASD experiencing a fracture of 
the cervicothoracic region are at high risk of developing complications. The 
posterior instrumentation of cervical spinal fractures related to ASD is 
recommended due to biomechanical superiority.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); titanium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing hyperostosis; ankylosing spondylitis; bone screw (adverse device effect); cervical spine fracture (surgery); cervicothoracic fracture (surgery); medical device complication (complication); 
EMTREE MEDICAL INDEX TERMS
  aged; arm pain (complication); article; clinical article; cohort analysis; controlled study; epidural hematoma; female; follow up; human; laminectomy; liquorrhea (complication); lung insufficiency (complication); male; neck pain (complication); nuclear magnetic resonance imaging; pneumonia (complication); postoperative complication (complication); postoperative infection (complication, drug therapy); postoperative pain (complication); priority journal; prospective study; reoperation; skull clamp; 
CAS REGISTRY NUMBERS
  titanium (7440-32-6)
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014970782
MEDLINE PMID
  25494322 (http://www.ncbi.nlm.nih.gov/pubmed/25494322)
PUI
  L600775483
DOI
  10.1097/BRS.0000000000000726
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0000000000000726
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0000000000000726&atitle=Complications+and+survival+after+long+posterior+instrumentation+of+cervical+and+cervicothoracic+fractures+related+to+ankylosing+spondylitis+or+diffuse+idiopathic+skeletal+hyperostosis&stitle=Spine&title=Spine&volume=40&issue=4&spage=E227&epage=E233&aulast=Robinson&aufirst=Yohan&auinit=Y.&aufull=Robinson+Y.&coden=SPIND&isbn=&pages=E227-E233&date=2015&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 350
TITLE
  Pharyngoesophageal perforation 3 years after anterior cervical spine 
surgery: a rare case report and literature review
AUTHOR NAMES
  Yin D.-H.; Yang X.-M.; Huang Q.; Yang M.; Tang Q.-L.; Wang S.-H.; Wang S.; Liu J.-J.; Yang T.; Li S.-S.
AUTHOR ADDRESSES
  (Yin D.-H.; Yang X.-M.; Yang M.; Tang Q.-L.; Wang S.-H.; Wang S.; Liu J.-J.; 
Yang T.; Li S.-S., 254546199@qq.com) Department of Otolaryngology, Head and 
Neck Surgery, the Second Xiangya Hospital, Central South University, 
Changsha, China.
(Huang Q.) Department of Thoracic Surgery, the Second Xiangya Hospital, 
Central South University, Changsha, China.
CORRESPONDENCE ADDRESS
  S.-S. Li, Department of Otolaryngology, Head and Neck Surgery, the Second 
Xiangya Hospital, Central South University, Changsha, China.
AiP/IP ENTRY DATE
  2015-02-19
FULL RECORD ENTRY DATE
  2015-06-30
SOURCE
  European Archives of Oto-Rhino-Laryngology (2015) 272:8 (2077-2082). Date of 
Publication: 6 Jan 2015
VOLUME
  272
ISSUE
  8
FIRST PAGE
  2077
LAST PAGE
  2082
DATE OF PUBLICATION
  6 Jan 2015
ISSN
  1434-4726 (electronic)
  0937-4477
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Pharyngoesophageal perforation after anterior cervical spine surgery is rare 
and the delayed cases were more rarely reported but potentially 
life-threatening. We report a case of pharyngoesophageal perforation 3 years 
after anterior cervical spine surgery. The patient presented with dysphagia, 
fever, left cervical mass and developing dyspnea 3 years after cervical 
spine surgery for trauma. After careful examinations, he underwent an 
emergency tracheostomy, neck exploration, hardware removal, abscess drainage 
and infected tissue debridement. 14 days after surgery, CT of the neck with 
oral contrast demonstrated no contrast extravasation from the esophagus. 
Upon review of literature, only 14 cases of pharyngoesophageal perforation 
more than 1 year after anterior cervical spine surgery were found. We 
discussed possible etiology, diagnosis and management and concluded that in 
cases of dysphagia, dyspnea, cervical pain, swelling and edema of the 
cervical area even long time after anterior cervical spine surgery, 
potential pharyngoesophageal damage should be considered.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical spine surgery; esophagus perforation (complication, diagnosis, surgery); pharyngoesophageal perforation (complication, diagnosis, surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  abscess drainage; adult; article; case report; cervical plate; computer assisted tomography; debridement; dysphagia; dyspnea; esophagography; fever; human; male; neck pain; priority journal; spine tumor; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015729556
MEDLINE PMID
  25559465 (http://www.ncbi.nlm.nih.gov/pubmed/25559465)
PUI
  L602143162
DOI
  10.1007/s00405-014-3483-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00405-014-3483-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14344726&id=doi:10.1007%2Fs00405-014-3483-7&atitle=Pharyngoesophageal+perforation+3%C2%A0years+after+anterior+cervical+spine+surgery%3A+a+rare+case+report+and+literature+review&stitle=Eur.+Arch.+Oto-Rhino-Laryngol.&title=European+Archives+of+Oto-Rhino-Laryngology&volume=272&issue=8&spage=2077&epage=2082&aulast=Yin&aufirst=Dan-hui&auinit=D.-H.&aufull=Yin+D.-H.&coden=EAOTE&isbn=&pages=2077-2082&date=2015&auinit1=D&auinitm=-H
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 351
TITLE
  Asia impairment scale predicts the need for tracheostomy after cervical 
spinal cord injury
AUTHOR NAMES
  Childs B.R.; Moore T.A.; Como J.J.; Vallier H.A.
AUTHOR ADDRESSES
  (Childs B.R.; Moore T.A.; Como J.J.; Vallier H.A.) Cleveland, United States.
CORRESPONDENCE ADDRESS
  B.R. Childs, Cleveland, United States.
FULL RECORD ENTRY DATE
  2018-10-02
SOURCE
  Spine (2015) 2015 Supplement 2 (415). Date of Publication: 2015
VOLUME
  2015
FIRST PAGE
  415
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  43rd Annual Meeting of the Cervical Spine Research Society, CSRS 2015
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2015-12-03 to 2015-12-05
ISSN
  1528-1159
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: High neurologic level of injury, high Injury Severity Score 
(ISS), and low Glasgow Coma Scale (GCS) have been shown to predict 
tracheostomy in patients with cervical spinal cord injury. The objective of 
this study was to evaluate the ability of the American Spinal Injury 
Association (ASIA) impairment scale and neurological level of injury to 
predict the need for mechanical ventilation as well as tracheostomy. 
Methods: Three hundred eighty-three patients with fractures, dislocations, 
or ligamentous injury of the cervical spine were included in this 
retrospective study. Charts were reviewed to determine demographics, ISS, 
GCS, presence and severity of chest injuries, length of hospital stay (LOS), 
ICU stay, mechanical ventilation time, and mortality. Results: Fifty-nine 
patients (15.4%) underwent tracheostomy. An ASIA impairment scale of A had a 
specificity of 98.8% and sensitivity of 32.2% for predicting the need for 
tracheostomy. This yielded a 1.2% false positive rate. The ASIA impairment 
Scale remained the most significant predictor for tracheostomy after 
regression for ISS, GCS, and Chest Abbreviated Injury Scale. Neurological 
level of injury was not a significant predictor of tracheostomy. 
Conclusions: An ASIA impairment scale of A at any level of injury is a 
specific predictor of the need for tracheostomy with a low false positive 
rate. Given the relatively low risk of early tracheostomy and the potential 
benefits, an ASIA impairment scale of A would be a sensible early criterion 
to determine the need for tracheostomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American Spinal Injury Association impairment scale; cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; conference abstract; diagnostic test accuracy study; dislocation; female; fracture; Glasgow coma scale; hospitalization; human; ligament injury; major clinical study; male; mortality; retrospective study; sensitivity and specificity; thorax injury; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624067781
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:&atitle=Asia+impairment+scale+predicts+the+need+for+tracheostomy+after+cervical+spinal+cord+injury&stitle=Spine&title=Spine&volume=2015&issue=&spage=415&epage=&aulast=Childs&aufirst=Benjamin+R.&auinit=B.R.&aufull=Childs+B.R.&coden=&isbn=&pages=415-&date=2015&auinit1=B&auinitm=R
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 352
TITLE
  Predictors of the necessity for early tracheostomy in patients with acute 
cervical spinal cord injury: A 15-year experience
AUTHOR NAMES
  Jones T.S.; Burlew C.C.; Johnson J.L.; Jones E.; Kornblith L.Z.; Biffl W.L.; Stovall R.T.; Pieracci F.M.; Stahel P.F.; Moore E.E.
AUTHOR ADDRESSES
  (Jones T.S.; Burlew C.C., clay.cothren@dhha.org; Johnson J.L.; Jones E.; 
Kornblith L.Z.; Biffl W.L.; Stovall R.T.; Pieracci F.M.; Moore E.E.) 
Department of Surgery, Denver Health Medical Center, University of Colorado 
Denver, 777 Bannock Street, Denver, United States.
(Stahel P.F.) Department of Orthopedics, Denver Health Medical Center, 
Denvera, United States.
CORRESPONDENCE ADDRESS
  C.C. Burlew, Department of Surgery, Denver Health Medical Center, University 
of Colorado Denver, 777 Bannock Street, Denver, United States.
AiP/IP ENTRY DATE
  2015-02-18
FULL RECORD ENTRY DATE
  2015-02-24
SOURCE
  American Journal of Surgery (2015) 209:2 (363-368). Date of Publication: 1 
Feb 2015
VOLUME
  209
ISSUE
  2
FIRST PAGE
  363
LAST PAGE
  368
DATE OF PUBLICATION
  1 Feb 2015
ISSN
  1879-1883 (electronic)
  0002-9610
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background The need for mechanical ventilation (MV) after spinal cord injury 
(SCI) is a risk factor for prolonged critical care. The "purpose" of this 
study was to identify the level of cervical SCI that requires MV, thereby 
defining candidates for tracheostomy. Methods Patients with cervical SCI 
over a 15-year period were reviewed. Results One hundred sixty-three 
patients sustained cervical SCI. Of 76 complete injuries, 91% required MV 
for greater than 48 hours. By injury level, MV incidence was 100% for C2-4, 
91% for C5, 79% for C6, and 80% for C7. Only one quarter of patients with 
incomplete SCI required MV for greater than 48 hours; Glascow Coma Score and 
Injury Severity Score were significantly worse compared with patients not 
requiring MV. Conclusions Factors influencing the decision for tracheostomy 
in cervical SCI patients include the presence of a complete SCI, anatomic 
level of injury, Glascow Coma Score, Injury Severity Score, and associated 
thoracic injury. Patients with complete cervical SCI often require prolonged 
MV. Conversely, the minority of incomplete SCI required MV; the need for 
tracheostomy was likely performed for associated injuries. Utilizing 
identified factors permits a thoughtful approach to tracheostomy in this 
patient population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  acute disease; adult; article; artificial ventilation; female; Glasgow coma scale; hospital discharge; hospitalization; human; injury scale; major clinical study; male; outpatient department; prediction; priority journal; spine stabilization; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015741494
MEDLINE PMID
  25457250 (http://www.ncbi.nlm.nih.gov/pubmed/25457250)
PUI
  L602219920
DOI
  10.1016/j.amjsurg.2014.07.016
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.amjsurg.2014.07.016
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18791883&id=doi:10.1016%2Fj.amjsurg.2014.07.016&atitle=Predictors+of+the+necessity+for+early+tracheostomy+in+patients+with+acute+cervical+spinal+cord+injury%3A+A+15-year+experience&stitle=Am.+J.+Surg.&title=American+Journal+of+Surgery&volume=209&issue=2&spage=363&epage=368&aulast=Jones&aufirst=Teresa+S.&auinit=T.S.&aufull=Jones+T.S.&coden=AJSUA&isbn=&pages=363-368&date=2015&auinit1=T&auinitm=S
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 353
TITLE
  Spinal muscular atrophy type 1: Impact of NIV on survival and gastrostomy 
decision in the UK setting
AUTHOR NAMES
  Sframeli M.; Abel F.; Craig F.; Curry J.; Scoto M.; Muntoni F.; Manzur A.Y.
AUTHOR ADDRESSES
  (Sframeli M.; Abel F.; Craig F.; Curry J.; Scoto M.; Muntoni F.; Manzur 
A.Y.) Dubowitz Neuromuscular Centre, Great Ormond Street Hospital, London, 
United Kingdom.
CORRESPONDENCE ADDRESS
  M. Sframeli, Dubowitz Neuromuscular Centre, Great Ormond Street Hospital, 
London, United Kingdom.
FULL RECORD ENTRY DATE
  2015-02-03
SOURCE
  Developmental Medicine and Child Neurology (2015) 57 SUPPL. 1 (14). Date of 
Publication: January 2015
VOLUME
  57
FIRST PAGE
  14
DATE OF PUBLICATION
  January 2015
CONFERENCE NAME
  41st Annual Meeting of the British Paediatric Neurology Association, BPNA 
2015
CONFERENCE LOCATION
  Gateshead, United Kingdom
CONFERENCE DATE
  2015-01-21 to 2015-01-23
ISSN
  0012-1622
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Objective: The current figures on NIV use in SMA1 in the UK are not 
available. We aim to evaluate the current clinical practice of NIV, 
nasogastric tube (NGT), gastrostomy feeding and survival in a cohort of 
SMAI. Methods: Retrospectively case note review of SMAI patients at Great 
Ormond Street Hospital over the last 5 years. Patients were subdivided in 
three groups determined by the age of onset of symptoms (before 3mo, 3- 6mo, 
after 6mo). The prevailing practice entailed NIV support discussion with all 
families, and gastrostomy in infants with anticipated longer survival. 
Results: Forty infants with SMA1 were identified. 21 families chose NIV 
support. 5 infants did not tolerate NIV. 16 infants used night-time NIVt 
(mean age of starting NIV: 10 m) and 5 went on to require NIV 16 hours/day. 
No infant underwent tracheostomy. 29/40 infants received NGT, and 7 
underwent gastrostomy. The median of age at gastrostomy was 18 months. 30 
infants died at the median age of 7.5 months (mean 10.7 m). Median age at 
death in 8 NIV supported infants was 21.5 months, and 5.5 months in 5 
infants who did not tolerate NIV. 8 infants on NIV are still alive at a 
median age 35.7 months (range 12-87m). Median age at death, stratified by 
age at onset: onset <3 months=6 months, onset 3-6 months=9.5 months, onset 
>6 months=17.8 months. Of the infants who survived >2 years, the age of 
onset was 3-6 months in 1 and >6 months in 4. Conclusions: NIV support 
increased survival in this SMA1 cohort in UK with important implications for 
service models and resource allocation. The optimal timing of gastrostomy 
insertion needs clarification. There is a range of severity SMA1 and key 
management decisions should take account of age of onset/severity and 
prognosis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gastrostomy; neurology; spinal muscular atrophy; survival; United Kingdom; 
EMTREE MEDICAL INDEX TERMS
  clinical practice; death; feeding; hospital; human; infant; model; nasogastric tube; night; onset age; patient; prognosis; resource allocation; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71754010
DOI
  10.1111/dmcn.12653
FULL TEXT LINK
  http://dx.doi.org/10.1111/dmcn.12653
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00121622&id=doi:10.1111%2Fdmcn.12653&atitle=Spinal+muscular+atrophy+type+1%3A+Impact+of+NIV+on+survival+and+gastrostomy+decision+in+the+UK+setting&stitle=Dev.+Med.+Child+Neurol.&title=Developmental+Medicine+and+Child+Neurology&volume=57&issue=&spage=14&epage=&aulast=Sframeli&aufirst=M.&auinit=M.&aufull=Sframeli+M.&coden=&isbn=&pages=14-&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 354
TITLE
  Recent thoraco-abdominal aortic repair outcomes using moderate-to-deep 
hypothermia combined with targeted reconstruction of the Adamkiewicz artery
AUTHOR NAMES
  Tanaka H.; Minatoya K.; Sasaki H.; Seike Y.; Itonaga T.; Oda T.; Kobayashi J.
AUTHOR ADDRESSES
  (Tanaka H., hirtanak@hsp.ncvc.go.jp; Minatoya K.; Sasaki H.; Seike Y.; 
Itonaga T.; Oda T.; Kobayashi J.) National Cerebral and Cardiovascular 
Center, 5-7-1, Fujishirodai, Suita, Osaka, Japan.
CORRESPONDENCE ADDRESS
  H. Tanaka, National Cerebral and Cardiovascular Center, 5-7-1, Fujishirodai, 
Suita, Osaka, Japan.
AiP/IP ENTRY DATE
  2015-05-28
FULL RECORD ENTRY DATE
  2015-06-01
SOURCE
  Interactive Cardiovascular and Thoracic Surgery (2015) 20:5 (605-610). Date 
of Publication: 1 May 2015
VOLUME
  20
ISSUE
  5
FIRST PAGE
  605
LAST PAGE
  610
DATE OF PUBLICATION
  1 May 2015
ISSN
  1569-9285 (electronic)
  1569-9293
BOOK PUBLISHER
  Oxford University Press, jnl.info@oup.co.uk
ABSTRACT
  OBJECTIVES We retrospectively reviewed the surgical results of 
thoraco-abdominal aortic repair using moderate-to-deep hypothermia combined 
with targeted reconstruction of the Adamkiewicz artery (AKA). METHODS 
Between 2006 and 2014, 100 patients underwent thoraco-abdominal aortic 
aneurysm repair using moderate-to-deep hypothermia. Their mean age was 58 ± 
15 years and 76 (76%) were men. Their aortic pathologies included acute 
dissection (5), chronic dissection (74), degeneration (20) and infection 
(1). Thirty-four had connective tissue disorders and 5 had emergency 
operations. The degrees of repair were Crawford extent I for 11, II for 76 
and III for 13. Seven had concomitant arch repair. Preoperative magnetic 
resonance angiography or computed tomographic angiography was performed to 
detect the AKA in 95. We used deep hypothermia (18°C) for those requiring 
open proximal aortic anastomosis for cerebral protection and moderate 
hypothermia (25°C) for those not requiring open proximal aortic anastomosis. 
RESULTS Two patients had spinal cord injuries and 4 had a stroke. For those 
in whom the AKA was identified (90%), all had targeted artery 
reconstruction. The mean pairs of reconstructed intercostal arteries were 
1.5 ± 0.7. There were 5 in-hospital deaths for which the causes were lung 
bleeding (2), infection (2) and iliac aneurysm rupture (1). Temporary 
dialysis for new-onset renal failure was required for 9. The mean 
postoperative mechanical ventilation period was 1.7 ± 1.9 days. Six required 
a tracheostomy due to respiratory failure. CONCLUSIONS Moderate-to-deep 
hypothermia combined with targeted reconstruction of the AKA provided 
satisfactory outcomes with thoraco-abdominal aortic repair, particularly for 
spinal cord protection.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Adamkiewicz artery; aortic reconstruction; artery; artery reconstruction; induced hypothermia; moderate to deep hypothermia; targeted artery reconstruction; thoraco abdominal aortic repair; 
EMTREE MEDICAL INDEX TERMS
  adult; aneurysm rupture; article; artificial ventilation; cause of death; cerebrovascular accident; controlled study; dialysis; female; human; iliac aneurysm rupture; infection; intercostal artery; kidney failure (therapy); lung hemorrhage; major clinical study; male; middle aged; onset age; outcome assessment; postoperative care; priority journal; respiratory failure (surgery); spinal cord injury; surgical anatomy; surgical mortality; tracheostomy; treatment duration; treatment response; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Gastroenterology (48)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015062296
MEDLINE PMID
  25662957 (http://www.ncbi.nlm.nih.gov/pubmed/25662957)
PUI
  L604479211
DOI
  10.1093/icvts/ivv013
FULL TEXT LINK
  http://dx.doi.org/10.1093/icvts/ivv013
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15699285&id=doi:10.1093%2Ficvts%2Fivv013&atitle=Recent+thoraco-abdominal+aortic+repair+outcomes+using+moderate-to-deep+hypothermia+combined+with+targeted+reconstruction+of+the+Adamkiewicz+artery&stitle=Interact.+Cardiovasc.+Thorac.+Surg.&title=Interactive+Cardiovascular+and+Thoracic+Surgery&volume=20&issue=5&spage=605&epage=610&aulast=Tanaka&aufirst=Hiroshi&auinit=H.&aufull=Tanaka+H.&coden=ICTSC&isbn=&pages=605-610&date=2015&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 355
TITLE
  Modified total arch replacement using a four-branched arch graft for acute 
type a aortic dissection with minimal brain and spinal cord ischemic time
AUTHOR NAMES
  Lu S.; Sun X.; Hong T.; Yang S.; Song K.; Lai H.; Wang C.
AUTHOR ADDRESSES
  (Lu S.; Sun X.; Hong T.; Yang S.; Lai H.; Wang C., gordonsd@126.com) 
Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan 
University, Fenglin Road 180, Xujiahui District, Shanghai, China.
(Lu S.; Sun X.; Hong T.; Yang S.; Song K.; Lai H.; Wang C., 
gordonsd@126.com) Department of Cardiovascular Surgery, Zhongshan Hospital, 
Fudan University, Shanghai, China.
CORRESPONDENCE ADDRESS
  C. Wang, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, 
Fudan University, Fenglin Road 180, Xujiahui District, Shanghai, China. 
Email: gordonsd@126.com
AiP/IP ENTRY DATE
  2015-11-20
FULL RECORD ENTRY DATE
  2015-11-24
SOURCE
  Journal of Cardiovascular Surgery (2015) 56:4 (519-524). Date of 
Publication: 1 Aug 2015
VOLUME
  56
ISSUE
  4
FIRST PAGE
  519
LAST PAGE
  524
DATE OF PUBLICATION
  1 Aug 2015
ISSN
  0021-9509
BOOK PUBLISHER
  Edizioni Minerva Medica, subscriptions.dept@minervamedica.it
ABSTRACT
  Aim: This study aimed to evaluate the results of modified surgical 
strategies of total arch replacement using a four-branched arch graft, 
stented elephant trunk, and innovative organ protection method for acute 
type A aortic dissection. Methods: Between August 2011 and December 2011, 21 
patients with acute type A aortic dissection underwent modified total arch 
replacement using the four-branched arch graft technique. All 21 patients 
had emergency surgery. Five patients had undergone previous aortic or 
cardiac surgery. The operations were stented elephant trunk implantation in 
17 patients, ascending aorta replacement in 21 patients, coronary artery 
bypass grafting in four patients, Bentall operation in two patients, and 
aortic valve replacement in one patient. Twenty-one operations were 
performed under deep hypothermic extracorporeal circulation, modified 
selective cerebral perfusion, and end-organ and spinal cord protection for 
arch reconstruction. Results: There was two in-hospital deaths (9.5%). No 
persisting neurologic deficits or paraplegia occurred in 21 patients. 
Cardiopulmonary bypass time was 177.9±37.8 minutes. Myocardial ischemic time 
was 110.3±29.3 minutes. ICU time was 8.8±6.9 days and in-hospital duration 
was 28.7±13.7 days. Ventilation time varied from 9 hours to 21 days. A 
tracheotomy was necessary in four patients. Mean follow-up was 7.3±1.7 
months and all patients are still alive. Conclusion: Modified total arch 
replacement using a four-branched arch graft with stented elephant trunk and 
innovative organ protection is a useful and safe alternative technique for 
the treatment of acute type A aortic dissection and the results are 
encouraging.
EMTREE DRUG INDEX TERMS
  creatinine (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic arch surgery; aortic dissection (surgery); aortic graft; brain ischemia; heart muscle ischemia (surgery); spinal cord ischemia; total arch replacement; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; aortic prosthesis; article; cardiopulmonary bypass; cause of death; clinical article; creatinine blood level; female; follow up; human; hypoxemia (complication); intensive care; kidney failure (complication); male; multiple organ failure (complication); operation duration; paraplegia; postoperative hemorrhage (complication); reoperation; sternotomy; surgical mortality; tracheotomy; 
CAS REGISTRY NUMBERS
  creatinine (19230-81-0, 60-27-5)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015514647
MEDLINE PMID
  23752671 (http://www.ncbi.nlm.nih.gov/pubmed/23752671)
PUI
  L606909463
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00219509&id=doi:&atitle=Modified+total+arch+replacement+using+a+four-branched+arch+graft+for+acute+type+a+aortic+dissection+with+minimal+brain+and+spinal+cord+ischemic+time&stitle=J.+Cardiovasc.+Surg.&title=Journal+of+Cardiovascular+Surgery&volume=56&issue=4&spage=519&epage=524&aulast=Lu&aufirst=S.&auinit=S.&aufull=Lu+S.&coden=JCVSA&isbn=&pages=519-524&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 356
TITLE
  Outcomes of open repair of mycotic descending thoracic and thoracoabdominal 
aortic aneurysms
AUTHOR NAMES
  Lau C.; Gaudino M.; De Biasi A.R.; Munjal M.; Girardi L.N.
AUTHOR ADDRESSES
  (Lau C., chl9077@med.cornell.edu; Gaudino M.; De Biasi A.R.; Munjal M.; 
Girardi L.N.) Department of Cardiothoracic Surgery, Weill Cornell Medical 
College, New York, United States.
CORRESPONDENCE ADDRESS
  C. Lau, Box 110, 525 E 68th St, New York, United States.
AiP/IP ENTRY DATE
  2015-08-28
FULL RECORD ENTRY DATE
  2015-11-10
SOURCE
  Annals of Thoracic Surgery (2015) 100:5 (1712-1717). Date of Publication: 1 
Nov 2015
VOLUME
  100
ISSUE
  5
FIRST PAGE
  1712
LAST PAGE
  1717
DATE OF PUBLICATION
  1 Nov 2015
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background The purpose of this study was to evaluate the short- and 
intermediate-term outcomes of open repair of mycotic thoracic and 
thoracoabdominal aneurysms. Contemporary surgical and perioperative 
techniques were utilized. Methods From November 1997 to May 2014, 14 
consecutive patients underwent open repair of descending thoracic (n = 9, 
64.3%) and thoracoabdominal (n = 5, 35.7%) mycotic aortic aneurysms. All 
procedures were performed through the left side of the chest. Infected 
tissue was completely debrided and excised. Aortic continuity was restored 
in situ with a Dacron prosthesis (Macquet Corp, Oakland, NJ). Soft tissue 
coverage of the prosthesis was performed when anatomy and patient condition 
permitted. Perioperative outcomes, intermediate-term survival, and 
reinfection rates were examined. Results All patients presented with either 
aneurysm-related symptoms or a clinical picture of sepsis. Diagnosis was 
confirmed utilizing computed tomography imaging. Mean age was 66 ± 13 years, 
8 patients (57.1%) were male, and mean aneurysm size was 5.9 ± 1.3 cm. All 
patients were hypertensive, 3 (21.4%) had prior coronary revascularization, 
7 (50%) had chronic pulmonary disease, 5 (35.7%) had diabetes mellitus, and 
2 (14.3%) had end-stage renal disease requiring dialysis. Twelve patients 
(85.7%) had aneurysm-related pain, and 9 (64.3%) of them had contained 
rupture. Mean time from onset of illness to surgery was 36 days (range, 0 to 
153). On preoperative blood cultures, 4 (28.6%) grew Staphylococcus aureus, 
4 (28.6%) grew gram negative organisms, 2 (14.3%) grew mycobacterium, and 4 
cultures (28.6%) had negative results. Empiric broad-spectrum antibiotics 
were initiated on all patients and adjusted based on final cultures. A 
majority of patients underwent repair utilizing a clamp-and-sew technique (n 
= 10, 71.4%); the remainder (n = 4, 28.6%) required repair under profound 
hypothermic circulatory arrest. After radical debridement of the infected 
tissue, grafts were placed in the normal anatomic position; 6 (42.9%) 
patients had additional soft tissue coverage, 5 (35.7%) utilizing an omental 
flap and 1 (7.1%), a serratus muscle flap. There was 1 in-hospital death 
(7.1%) secondary to ischemic bowel. Four patients (28.6%) required 
tracheostomy, and 1 (7.1%) had recurrent nerve injury. None of the patients 
incurred spinal cord injury, stroke, or new onset renal failure requiring 
dialysis. After surgery, all patients were given 6 weeks of intravenous 
antibiotics. Lifelong suppression therapy was maintained with oral 
antibiotics. There were no episodes of prosthetic graft infection on 
follow-up. Univariate analysis revealed that New York Heart Association 
functional class, diabetes, and preoperative renal dysfunction were 
preoperative risk factors for major adverse events. Mean follow-up time was 
26.5 months (median 8.2; range, 1 to 142). Actuarial 5-year survival was 
71%. Conclusions Open repair of mycotic descending thoracic and 
thoracoabdominal aortic aneurysms remains the gold standard of therapy. 
Aggressive intraoperative debridement with in situ prosthetic reconstruction 
permits a high rate of success in this very high risk cohort of patients. 
Lifelong antibiotic suppression therapy may prevent late prosthetic graft 
infection.
EMTREE DRUG INDEX TERMS
  nafcillin; oxacillin; piperacillin plus tazobactam; sultamicillin; vancomycin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  mycotic aneurysm (surgery); mycotic descending thoracic aortic aneurysm (surgery); thoracoabdominal aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; blood culture; cardiac patient; cardiovascular risk; cerebrovascular accident; chronic lung disease; clinical article; cohort analysis; computer assisted tomography; deep hypothermic circulatory arrest; diabetes mellitus; end stage renal disease (therapy); female; follow up; gold standard; heart muscle revascularization; human; hypertension; male; mean arterial pressure; New York Heart Association class; outcome assessment; peritoneal dialysis; positron emission tomography; priority journal; prospective study; salmonellosis; spinal cord injury; Staphylococcus aureus; sternotomy; surgical patient; tracheostomy; treatment duration; tuberculosis (drug therapy); 
CAS REGISTRY NUMBERS
  nafcillin (147-52-4, 985-16-0)
  oxacillin (1173-88-2, 66-79-5, 7240-38-2)
  sultamicillin (76497-13-7)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015323381
MEDLINE PMID
  26277557 (http://www.ncbi.nlm.nih.gov/pubmed/26277557)
PUI
  L605758312
DOI
  10.1016/j.athoracsur.2015.05.067
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2015.05.067
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2015.05.067&atitle=Outcomes+of+open+repair+of+mycotic+descending+thoracic+and+thoracoabdominal+aortic+aneurysms&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=100&issue=5&spage=1712&epage=1717&aulast=Lau&aufirst=Christopher&auinit=C.&aufull=Lau+C.&coden=ATHSA&isbn=&pages=1712-1717&date=2015&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 357
TITLE
  An autopsied case of adult-onset bulbospinalform Alexander disease with a 
novel S393R mutation in the GFAP gene
AUTHOR NAMES
  Iwasaki Y.; Saito Y.; Mori K.; Ito M.; Mimuro M.; Aiba I.; Saito K.; Mizuta I.; Yoshida T.; Nakagawa M.; Yoshida M.
AUTHOR ADDRESSES
  (Iwasaki Y., iwasaki@sc4.so-net.ne.jp; Mimuro M.; Yoshida M.) Department of 
Neuropathology, Institute for Medical Science of Aging, Aichi Medical 
University, Japan.
(Saito Y.; Aiba I.) Department of Neurology, National Hospital Organization 
Higashi Nagoya National Hospital, Nagoya, Japan.
(Mori K.; Ito M.) Department of Neurology, Oyamada Memorial Spa Hospital, 
Yokkaichi, Japan.
(Saito K.; Mizuta I.; Yoshida T.) Department of Neurology, Graduate School 
of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
(Nakagawa M.) Division of Neurology, North Medical Center, Kyoto Prefectural 
University of Medicine, Kyoto, Japan.
CORRESPONDENCE ADDRESS
  Y. Iwasaki, Department of Neuropathology, Institute for Medical Science of 
Aging, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Japan.
AiP/IP ENTRY DATE
  2015-06-04
FULL RECORD ENTRY DATE
  2015-06-11
SOURCE
  Clinical Neuropathology (2015) 34:4 (207-214). Date of Publication: 2015
VOLUME
  34
ISSUE
  4
FIRST PAGE
  207
LAST PAGE
  214
DATE OF PUBLICATION
  2015
ISSN
  0722-5091
BOOK PUBLISHER
  Dustri-Verlag Dr. Karl Feistle, Bajuwarenring 4, Oberhaching, Germany.
ABSTRACT
  A 50-year-old Japanese man with no apparent family history noticed diplopia. 
He gradually showed gait disturbance and dysuria. Abducens disorder of eye 
movement with nystagmus, tongue atrophy with fasciculation, spastic 
tetraparesis, and sensory disturbance were also observed. MRI showed severe 
atrophy of the medulla oblongata to the cervical cord ("tadpole 
appearance"). Tracheotomy and gastrostomy were performed 7 years after onset 
due to the development of bulbar palsy. Death occurred following respiratory 
failure after 11 years total disease duration. The brain weighed 1,380 g. 
The cerebrum, cerebellum, midbrain, and upper pons were preserved from 
atrophy, but the medulla oblongata to the cervical cord showed severe 
atrophy. A few Rosenthal fibers were observed in the cerebral white matter, 
basal ganglia, and cerebellum, whereas numerous Rosenthal fibers were 
observed in the medulla oblongata to the cervical cord. Myelin loss with 
relatively preserved axons was extensively observed from the middle of the 
pons to the spinal cord. The clinicopathological diagnosis was adult-onset 
bulbospinal-form Alexander disease. Glial fibrillary acidic protein (GFAP) 
gene analysis revealed a novel mutation of S393R. Expression patterns of 
S393R mutant GFAP using adrenal carcinoma-derived cells (SW13 cells) showed 
a decreased number of filamentous structures and abnormal aggregates.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  glial fibrillary acidic protein (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Alexander disease (etiology); gene mutation; 
EMTREE MEDICAL INDEX TERMS
  adrenal cortex carcinoma; adult; article; basal ganglion; bulbar paralysis; case report; cerebrospinal fluid; cervical spinal cord; disease duration; electroencephalography; eye movement; family history; fasciculation; gastrostomy; human; joint contracture; lung alveolus hypoventilation; male; medulla oblongata; middle aged; neurologic examination; nystagmus; priority journal; respiratory failure; tracheotomy; white matter; 
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015082991
MEDLINE PMID
  25828773 (http://www.ncbi.nlm.nih.gov/pubmed/25828773)
PUI
  L604611193
DOI
  10.5414/NP300806
FULL TEXT LINK
  http://dx.doi.org/10.5414/NP300806
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07225091&id=doi:10.5414%2FNP300806&atitle=An+autopsied+case+of+adult-onset+bulbospinalform+Alexander+disease+with+a+novel+S393R+mutation+in+the+GFAP+gene&stitle=Clin.+Neuropathol.&title=Clinical+Neuropathology&volume=34&issue=4&spage=207&epage=214&aulast=Iwasaki&aufirst=Yasushi&auinit=Y.&aufull=Iwasaki+Y.&coden=CLNPD&isbn=&pages=207-214&date=2015&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 358
TITLE
  Clinical Evaluation and Airway Management for Adults with Cervical Spine 
Instability
AUTHOR NAMES
  Martini R.P.; Larson D.M.
AUTHOR ADDRESSES
  (Martini R.P., martinir@ohsu.edu; Larson D.M.) Department of Anesthesiology 
and Perioperative Medicine, Oregon Health and Science University, 3181 SW 
Sam Jackson Park Road, Mail Code UHS-2, Portland, United States.
CORRESPONDENCE ADDRESS
  R.P. Martini, Department of Anesthesiology and Perioperative Medicine, 
Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail 
Code UHS-2, Portland, United States.
AiP/IP ENTRY DATE
  2015-04-20
FULL RECORD ENTRY DATE
  2015-06-09
SOURCE
  Anesthesiology Clinics (2015) 33:2 (315-327). Date of Publication: 1 Jun 
2015
VOLUME
  33
ISSUE
  2
FIRST PAGE
  315
LAST PAGE
  327
DATE OF PUBLICATION
  1 Jun 2015
ISSN
  2210-3538 (electronic)
  1932-2275
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Airway management of patients with cervical spine instability may be 
difficult as a result of immobilization, and may be associated with 
secondary neurologic injury related to cervical spine motion. Spinal cord 
instability is most common in patients with trauma, but there are additional 
congenital and acquired conditions that predispose to subacute cervical 
spine instability. Patients with suspected instability should receive 
immobilization during airway management with manual in-line stabilization. 
The best strategy for airway management is one that applies the technique 
with the highest likelihood of success on the first attempt and the lowest 
biomechanical influence on a potentially unstable spine.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (diagnosis, epidemiology); cervical spine instability (diagnosis, epidemiology); respiration control; spine instability (diagnosis, epidemiology); 
EMTREE MEDICAL INDEX TERMS
  ankylosing spondylitis; assisted ventilation; awake flexible fiberoptic intubation; cervical collar; cervical spine radiography; clinical evaluation; extubation; Glasgow coma scale; human; intervertebral disk; laryngoscopy; ligamentum flavum; low risk patient; neck pain; nuclear magnetic resonance imaging; odontoid process; pathogenesis; posterior longitudinal ligament; respiratory tract intubation; review; rheumatoid arthritis; second cervical vertebra; spinal cord injury; spiral computer assisted tomography; spondyloarthropathy; supraglottic airway device; tracheostomy; vertebra dislocation; videolaryngoscope; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015918673
MEDLINE PMID
  25999005 (http://www.ncbi.nlm.nih.gov/pubmed/25999005)
PUI
  L603719093
DOI
  10.1016/j.anclin.2015.02.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.anclin.2015.02.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22103538&id=doi:10.1016%2Fj.anclin.2015.02.004&atitle=Clinical+Evaluation+and+Airway+Management+for+Adults+with+Cervical+Spine+Instability&stitle=Anesthesiol.+Clin.&title=Anesthesiology+Clinics&volume=33&issue=2&spage=315&epage=327&aulast=Martini&aufirst=Ross+P.&auinit=R.P.&aufull=Martini+R.P.&coden=&isbn=&pages=315-327&date=2015&auinit1=R&auinitm=P
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 359
TITLE
  The impact of a multidisciplinary safety checklist on adverse procedural 
events during bedside bronchoscopy-guided percutaneous tracheostomy
AUTHOR NAMES
  Hazelton J.P.; Orfe E.C.; Colacino A.M.; Hunter K.; Capano-Wehrle L.M.; Lachant M.T.; Ross S.E.; Seamon M.J.
AUTHOR ADDRESSES
  (Hazelton J.P., hazelton-joshua@cooperhealth.edu; Orfe E.C.; Capano-Wehrle 
L.M.; Lachant M.T.; Ross S.E.) Division of Trauma, Cooper University 
Hospital, Camden, United States.
(Colacino A.M.) Department of Surgery, Cooper University Hospital, Camden, 
United States.
(Hunter K.) Cooper Research Institute, Cooper University Hospital, Camden, 
United States.
(Seamon M.J.) Division of Traumatology, Surgical Critical Care and Emergency 
Surgery, Hospital of the University of Pennsylvania, Philadelphia, United 
States.
CORRESPONDENCE ADDRESS
  J.P. Hazelton, 3 Cooper Plaza, Suite #411, Camden, United States.
AiP/IP ENTRY DATE
  2015-07-09
FULL RECORD ENTRY DATE
  2015-07-14
SOURCE
  Journal of Trauma and Acute Care Surgery (2015) 79:1 (111-116). Date of 
Publication: 3 Jul 2015
VOLUME
  79
ISSUE
  1
FIRST PAGE
  111
LAST PAGE
  116
DATE OF PUBLICATION
  3 Jul 2015
ISSN
  2163-0763 (electronic)
  2163-0755
BOOK PUBLISHER
  Lippincott Williams and Wilkins, LRorders@phl.lrpub.com
ABSTRACT
  BACKGROUND: Bedside procedures are seldom subject to the same safety 
precautions as operating room (OR) procedures. Since July 2013, we have 
performed a multidisciplinary checklist before all bedside 
bronchoscopy-guided percutaneous tracheostomy insertions (BPTIs). We 
hypothesized that the implementation of this checklist before BPTI would 
decrease adverse procedural events. METHODS: A prospective study of all 
patients who underwent BPTI after checklist implementation (PostCL, 
2013-2014, n = 63) at our Level I trauma center were compared to all 
patients (retrospectively reviewed historical controls) who underwent BPTI 
without the checklist (PreCL, 2010-2013, n = 184). Exclusion criteria 
included age less than 16 years, OR, and open tracheostomy. The checklist 
included both a procedural and timeout component with the trauma technician, 
respiratory therapist, nurse, and surgeon. Demographics and variables 
focusing on BPTI risk factors were compared. Variables associated with the 
primary end point, adverse procedural events, during univariate analysis 
were used in the multiple variable logistic regression model. A p ≤ 0.05 was 
significant. RESULTS: Of 247 study sample patients, no difference existed in 
body mass index, baseline mean arterial pressure, duration or mode of 
mechanical ventilation, cervical spine or maxillofacial injury, or previous 
neck surgery between PreCL and PostCL BPTI patients. PreCL patients were 
younger (48 [20] years vs. 57 [21] years, p < 0.01) but more often had 
adverse procedural events compared with PostCL patients (PreCL,14.1% vs. 
PostCL,3.2%, p = 0.020). After adjusting for age, vitals, BPTI risk factors, 
and intensive care unit duration after BPTI, multiple variable logistic 
regression determined that performing the safety checklist alone was 
independently associated with a 580% reduction in adverse procedural events 
(odds ratio, 5.8; p = 0.022). CONCLUSION: Our results suggest that the 
implementation of a multidisciplinary safety checklist similar to those used 
in the OR would benefit patients during invasive bedside procedures. LEVEL 
OF EVIDENCE: Therapeutic/care management study, level IV.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchoscopy; bronchoscopy guided percutaneous tracheostomy; checklist; patient safety; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; body mass; cervical spine injury; female; human; intensive care unit; major clinical study; male; maxillofacial injury; mean arterial pressure; middle aged; nurse; priority journal; prospective study; respiratory therapist; retrospective study; risk factor; surgeon; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015176992
MEDLINE PMID
  26091323 (http://www.ncbi.nlm.nih.gov/pubmed/26091323)
PUI
  L605095226
DOI
  10.1097/TA.0000000000000700
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0000000000000700
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0000000000000700&atitle=The+impact+of+a+multidisciplinary+safety+checklist+on+adverse+procedural+events+during+bedside+bronchoscopy-guided+percutaneous+tracheostomy&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=79&issue=1&spage=111&epage=116&aulast=Hazelton&aufirst=Joshua+P.&auinit=J.P.&aufull=Hazelton+J.P.&coden=&isbn=&pages=111-116&date=2015&auinit1=J&auinitm=P
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 360
TITLE
  Risk factors for dysphagia in acute cervical spinal cord injury
AUTHOR NAMES
  Hayashi T.; Maeda T.; Sakai H.; Morishita Y.; Shiba K.
AUTHOR ADDRESSES
  (Hayashi T.; Maeda T.; Sakai H.; Morishita Y.; Shiba K.) Fukuoka, Japan.
CORRESPONDENCE ADDRESS
  T. Hayashi, Fukuoka, Japan.
FULL RECORD ENTRY DATE
  2018-10-02
SOURCE
  Spine (2015) 2015 Supplement 2 (242-244). Date of Publication: 2015
VOLUME
  2015
FIRST PAGE
  242
LAST PAGE
  244
DATE OF PUBLICATION
  2015
CONFERENCE NAME
  43rd Annual Meeting of the Cervical Spine Research Society, CSRS 2015
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2015-12-03 to 2015-12-05
ISSN
  1528-1159
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Dysphagia following traumatic cervical spinal cord injury 
(CSCI) is an under-recognized complication that can lead to aspiration 
pneumonia, which is a significant cause of morbidity and mortality. Several 
authors have investigated dysphagia associated with CSCI, however, risk 
factors for dysphagia are still not well understood. The objective of this 
study was to elucidate the incidence and risk factors of dysphagia in 
patients with acute CSCI. Methods: A total of 464 consecutive patients with 
traumatic cervical spinal injury with and without spinal cord damage were 
treated at our institute and were registered in a database from January 2007 
to December 2014. All patients underwent CT, MRI, and neurological 
examination on admission. We retrospectively selected 298 patients based on 
following criteria: (1) admission within 3 days following injury, (2) 
patients with paresis or paralysis, (3) patients without brain injury. 
Neurological impairment scale was evaluated according to ASIA impairment 
scale (AIS), and level of injury was identified using CT and MRI. We 
analyzed the factors postulated to increase the risk for dysphagia, 
including the patient's age, neurological impairment scale grade, level of 
injury, tracheostomy, and operative treatment, using a multiple logistic 
regression model to compute odds ratios (ORs) and 95% confidence intervals 
(95% CI). Results: 298 eligible patients (256 males and 42 females) with an 
average age 61.4 ± 17.3 (range, 14-91 yr.) were identified during 8-year 
study period. 21 of 298 patients appeared to be suffering from dysphagia 
after CSCI (7.0%). All of them experienced evident aspiration and had to 
stop eating their meals due to aspiration. The neurological status revealed 
that 13 of those patients were AIS A, 6 patients were AIS B, and 2 patients 
were AIS C. 12 of 21 patients (57.1%) received tracheostomy (Table 1). 
Multivariable logistic regression analysis revealed that age > 72 years (OR: 
2.97, 95% CI: 1.01-9.02, p = 0.04), AIS A or B (OR: 8.00, 95% CI: 1.92-54.7, 
p = 0.003), presence of tracheostomy (OR: 13.8, 95% CI: 4.62-44.3, p < 
0.001) were significant risk factors (Table 2). Conclusions: The incidence 
of dysphagia after acute CSCI was 7.0%. Old age, severe neurological 
impairment scale, and presence of tracheostomy may be at risk for dysphagia 
after acute CSCI. When treating CSCI, understanding the risk factors of 
dysphagia is important to prevent aspiration pneumonia. [Table Presented].
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; dysphagia; risk factor; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; aspiration pneumonia; brain injury; conference abstract; eating; female; human; incidence; major clinical study; male; middle aged; multivariate logistic regression analysis; neurologic examination; nuclear magnetic resonance imaging; paresis; prevention; retrospective study; risk assessment; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L624067695
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:&atitle=Risk+factors+for+dysphagia+in+acute+cervical+spinal+cord+injury&stitle=Spine&title=Spine&volume=2015&issue=&spage=242&epage=244&aulast=Hayashi&aufirst=Tetsuo&auinit=T.&aufull=Hayashi+T.&coden=&isbn=&pages=242-244&date=2015&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 361
TITLE
  Highly unstable cervical spine injury in an infant: a case report
AUTHOR NAMES
  young Ha S.; Lee S.-H.; Kim E.-S.; Shin H.J.; Eoh W.
AUTHOR ADDRESSES
  (young Ha S.; Lee S.-H., sobotta72@hotmail.com; Kim E.-S.; Shin H.J.; Eoh 
W.) Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan 
University, School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, South 
Korea.
(young Ha S.) School of Medicine, Keimyung University, 56 Dalseong-ro, 
Jung-gu, Daegu, South Korea.
CORRESPONDENCE ADDRESS
  S.-H. Lee, Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan 
University, School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, South 
Korea.
AiP/IP ENTRY DATE
  2015-02-05
FULL RECORD ENTRY DATE
  2015-02-10
SOURCE
  Child's Nervous System (2015) 31:2 (341-346). Date of Publication: 2015
VOLUME
  31
ISSUE
  2
FIRST PAGE
  341
LAST PAGE
  346
DATE OF PUBLICATION
  2015
ISSN
  1433-0350 (electronic)
  0256-7040
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Summary: Although the rate of surgical intervention for pediatric cervical 
spine injuries has risen, none of these instrumentation techniques has been 
reported in children less than 1 year of age. Additional consideration with 
placement of wires or cables is not safe because of the presence of 
cartilaginous bone and poor bone strength. The authors report a technique of 
internal fixation without fusion using nonabsorbable synthetic suture in an 
infant with unstable cervical injury. Methods: A 5-month-old girl was 
transported to emergency department and computed tomography showed severe 
distraction injury at the C6-7 level with total disruption of the facet 
joints bilaterally. To improve her general condition, she was placed in a 
customized occipito-cervical brace until surgical stabilization could be 
performed. After 1 month, surgical fixation was performed. After removing 
all soft tissues at the appropriate level, a hole was made in the center of 
the superior articular process of C6. A nonabsorbable suture (2–0 Ethibond; 
Ethicon, Somerville, NJ, USA) was passed from the superior articular process 
to the facet joint. The suture was passed into the spinous process of the 
lower level, and it was progressively tightened and radiographs were taken 
until anatomic reduction was achieved. Results: After surgery, solid fusion 
was achieved. She was able to sit up in a stroller after 6  months. 
Conclusion: As surgical treatment of pediatric cervical spine injuries is 
unsuitable for infants, the Ethibond sutures are strong enough to hold and 
stabilize the spine. This suturing technique can be used as an alternative 
treatment for cervical injury in infants.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (diagnosis, rehabilitation, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; case report; cervical collar; cervical spine radiography; computer assisted tomography; conservative treatment; disease severity; emergency surgery; emergency ward; endotracheal intubation; female; fluoroscopy; general anesthesia; human; infant; neurologic examination; nuclear magnetic resonance imaging; ossification; osteosynthesis; polyester suture; poor general condition; priority journal; quadriplegia; rehabilitation care; soft tissue; spinal cord disease; spinal hematoma; spine surgery; surgical technique; suture technique; tracheostomy; traffic accident; vertebra body; 
DEVICE TRADE NAMES
  Ethibond  , United StatesEthicon

DEVICE MANUFACTURERS
   (United States)Ethicon
EMBASE CLASSIFICATIONS
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015706195
PUI
  L601761898
DOI
  10.1007/s00381-014-2527-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-014-2527-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14330350&id=doi:10.1007%2Fs00381-014-2527-z&atitle=Highly+unstable+cervical+spine+injury+in+an+infant%3A+a+case+report&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=31&issue=2&spage=341&epage=346&aulast=young+Ha&aufirst=Sue&auinit=S.&aufull=young+Ha+S.&coden=CNSYE&isbn=&pages=341-346&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 362
TITLE
  Pressure ulcer surveillance in neurotrauma patients at a level one trauma 
centre in India
AUTHOR NAMES
  Babu A.; Madhavan K.; Singhal M.; Sagar S.; Ranjan P.
AUTHOR ADDRESSES
  (Babu A.; Madhavan K.; Singhal M.; Sagar S.; Ranjan P., 
drpmishra28@gmail.com) Department of Surgical Disciplines, All India 
Institute of Medical Sciences, New Delhi, India.
CORRESPONDENCE ADDRESS
  P. Ranjan, Department of Surgical Disciplines, All India Institute of 
Medical Sciences, New Delhi, India.
AiP/IP ENTRY DATE
  2015-11-19
FULL RECORD ENTRY DATE
  2015-11-24
SOURCE
  Oman Medical Journal (2015) 30:6 (441-446). Date of Publication: 2015
VOLUME
  30
ISSUE
  6
FIRST PAGE
  441
LAST PAGE
  446
DATE OF PUBLICATION
  2015
ISSN
  2070-5204 (electronic)
  1999-768X
BOOK PUBLISHER
  Oman Medical Specialty Board, omsb@omsb.org
ABSTRACT
  Objectives: Pressure ulcers are a multifactorial, prevalent, and preventable 
morbidity. They cause a burden both financially and emotionally, to the 
individual, their family and doctor, and to society as a whole. Pressure 
ulcers are extremely difficult to treat; therefore, prevention is key. 
Methods: We started a Wound Care Surveillance Program in 2012 involving 
nurses, physiotherapists, and doctors. We intended to prevent the occurrence 
of pressure ulcers, ensure early detection, and facilitate the healing 
process. The Braden scale was used to stratify patients’ risk. The number of 
patients observed in our study was 2,974 over a one-year period. Results: 
The pressure sore prevalence was 3.1%. Younger and middle-aged patients were 
most commonly affected; 27% of these patients did not survive. Mortality was 
not attributed to the pressure ulcer directly. The most common mode of 
injury was road traffic accidents. Most of our patients had just a single 
pressure area affected, most commonly the sacrum. Most patients were managed 
with debridement and dressings while 12% received surgical treatment. Of 
those with stage one ulcers, 29% healed completely at two months. In stage 
two and three patients, 17% and 6% healed in two months, respectively, and 
this number was zero in stage four patients. Conclusion: The Wound Care 
Surveillance Program has been a very effective strategy for the prevention 
and management of pressure ulcers. Stage two ulcers were the most common in 
our setup. Braden scoring, traditionally used to screen these ulcers, can be 
used as a predictive and prognostic tool to predict healing of pressure 
ulcers. Poor healing is expected in higher staged ulcers and patients with 
spinal injury and major solid organ injury and those who need a 
tracheostomy. Home-based care is not up to mark in our society and accounts 
for most of the cases in the follow-up.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  decubitus (surgery, epidemiology); nervous system injury; 
EMTREE MEDICAL INDEX TERMS
  article; bandages and dressings; Braden Scale; debridement; disease surveillance; falling; female; Glasgow coma scale; health program; human; India; length of stay; major clinical study; male; mortality; observational study; paraplegia; prospective study; quadriplegia; self care; spine injury; split thickness skin graft; tracheostomy; traffic accident; ulcer healing; Wound Care Surveillance Program; 
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Public Health, Social Medicine and Epidemiology (17)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015512752
PUI
  L606810656
DOI
  10.5001/omj.2015.87
FULL TEXT LINK
  http://dx.doi.org/10.5001/omj.2015.87
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20705204&id=doi:10.5001%2Fomj.2015.87&atitle=Pressure+ulcer+surveillance+in+neurotrauma+patients+at+a+level+one+trauma+centre+in+India&stitle=Oman+Med.+J.&title=Oman+Medical+Journal&volume=30&issue=6&spage=441&epage=446&aulast=Babu&aufirst=Annu&auinit=A.&aufull=Babu+A.&coden=&isbn=&pages=441-446&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 363
TITLE
  Pediatric intramedullary spinal cord lesions: Pathological spectrum and 
outcome of surgery
AUTHOR NAMES
  Sahu R.K.; Das K.K.; Bhaisora K.S.; Singh A.K.; Mehrotra A.; Srivastava A.K.; Sahu R.N.; Jaiswal A.K.; Behari S.
AUTHOR ADDRESSES
  (Sahu R.K.; Das K.K.; Bhaisora K.S.; Singh A.K.; Mehrotra A.; Srivastava 
A.K.; Sahu R.N.; Jaiswal A.K., akjaiswal@sgpgi.ac.in; Behari S.) Department 
of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 
Rae Barely Road, Lucknow, Uttar Pradesh, India.
CORRESPONDENCE ADDRESS
  A.K. Jaiswal, Department of Neurosurgery, Sanjay Gandhi Postgraduate 
Institute of Medical Sciences, Rae Barely Road, Lucknow, Uttar Pradesh, 
India.
AiP/IP ENTRY DATE
  2015-10-01
FULL RECORD ENTRY DATE
  2015-10-06
SOURCE
  Journal of Pediatric Neurosciences (2015) 10:3 (214-221). Date of 
Publication: 1 Jul 2015
VOLUME
  10
ISSUE
  3
FIRST PAGE
  214
LAST PAGE
  221
DATE OF PUBLICATION
  1 Jul 2015
ISSN
  1998-3948 (electronic)
  1817-1745
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Background: Pediatric intramedullary spinal cord lesions are not only rare 
but also different from adults in a number of aspects. We aimed to study the 
incidence and the frequencies of various pediatric intramedullary mass 
lesions, their outcome to treatment and the factors determining their 
outcome of treatment. Materials and Methods: Thirty-one consecutive children 
(aged 1-18 years, mean 11.1 years, male: female = 1.8:1) with pathologically 
proven intramedullary spinal cord lesions treated at our center were 
studied. Clinico-radiological, histopathological, operative, and outcome 
data were reviewed retrospectively. The functional status was assessed using 
the modified McCormick grading system. Results: Gross total tumor excision 
was performed in 19 patients (61.3%), subtotal in 9 patients (29%), partial 
excision was performed in 2 (6.5%) patient, and only biopsy was performed in 
1 patient (6.5%). There was one peroperative death, 2 patients died at 
follow-up. Complications included wound related complications (n = 4), 
transient deterioration in the motor power, and respiratory complication 
requiring a tracheostomy. Six patients showed recurrence at a mean follow-up 
of 16.4 months. Developmental tumors, high-grade ependymomas, and 
incompletely excised grade 2 ependymomas showed a tendency to recur. 
Conclusions: Children constituted nearly 1/5 <sup>th</sup> (17.4%) of 
intramedullary spinal cord tumors. Astrocytomas and ependymomas taken 
together constituted the most common intramedullary spinal lesions in 
children; however, developmental tumors predominated in the first decade. 
Children usually presented in good functional grades preoperatively and 
maintained good grades after surgery. Functional outcome was dependent on 
the preoperative neurological status and histopathology of the lesions.
EMTREE DRUG INDEX TERMS
  lomustine (drug combination); procarbazine (drug combination); vincristine (drug combination); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood disease (etiology, surgery); pediatric intramedullary spinal cord lesion (etiology, surgery); spinal cord lesion (etiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; astrocytoma; backache; biopsy; bladder disease; cancer combination chemotherapy; cancer radiotherapy; cancer surgery; child; clinical article; clinical feature; ependymoma (surgery); epidermoid tumor; female; follow up; functional status; hemangioblastoma; histopathology; human; human tissue; incidence; lipoma; male; motor power transient deterioration (complication); multiple cycle treatment; neck pain; outcome assessment; postoperative complication (complication); respiratory tract disease (complication); retrospective study; spasticity; teratoma; tracheostomy; trigeminal nerve; tuberculoma; weakness; wound complication (complication); 
CAS REGISTRY NUMBERS
  lomustine (13010-47-4)
  procarbazine (366-70-1, 671-16-9)
  vincristine (57-22-7)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015405248
PUI
  L606161216
DOI
  10.4103/1817-1745.165660
FULL TEXT LINK
  http://dx.doi.org/10.4103/1817-1745.165660
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19983948&id=doi:10.4103%2F1817-1745.165660&atitle=Pediatric+intramedullary+spinal+cord+lesions%3A+Pathological+spectrum+and+outcome+of+surgery&stitle=J.+Pediatr.+Neurosci.&title=Journal+of+Pediatric+Neurosciences&volume=10&issue=3&spage=214&epage=221&aulast=Sahu&aufirst=Rajni+Kant&auinit=R.K.&aufull=Sahu+R.K.&coden=&isbn=&pages=214-221&date=2015&auinit1=R&auinitm=K
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 364
TITLE
  Tetraplegia after thyroidectomy in a patient with cervical spondylosis : A 
case report and literature review
AUTHOR NAMES
  Xiong W.; Li F.; Guan H.
AUTHOR ADDRESSES
  (Xiong W.; Li F.; Guan H., hguan@hust.edu.cn) Department of Orthopedic 
Surgery, Tongji Hospital, 1095 Jiefang Avenue, Wuhan, China.
CORRESPONDENCE ADDRESS
  H. Guan, Department of Orthopedic Surgery, Tongji Hospital, 1095 Jiefang 
Avenue, Wuhan, China.
AiP/IP ENTRY DATE
  2015-06-09
FULL RECORD ENTRY DATE
  2015-06-23
SOURCE
  Medicine (United States) (2015) 94:6 Article Number: e524. Date of 
Publication: 2 Feb 2015
VOLUME
  94
ISSUE
  6
DATE OF PUBLICATION
  2 Feb 2015
ISSN
  1536-5964 (electronic)
  0025-7974
BOOK PUBLISHER
  Lippincott Williams and Wilkins, LRorders@phl.lrpub.com
ABSTRACT
  Cervical spondylosis is degeneration of the cervical spine that occurs 
during the normal course of aging, and may progress into compression of the 
spinal cord, or cervical spondylotic myelopathy (CSM), which can cause 
neurologic dysfunction. Cervical spondylosis can be identified in the 
majority of people older than 50 years. Many people with cervical 
spondylosis or CSM are asymptomatic. However, patients with CSM are at 
higher risk of spinal cord injury (SCI) following minor injury. A 
60-year-old woman with asymptomatic cervical spondylosis underwent an 
elective subtotal thyroidectomy for thyroid nodules. After the surgery, she 
developed tetraplegia. MRI revealed spinal cord compression and injury. Main 
diagnoses, therapeutics interventions, and outcomes: Acute cervical SCI was 
diagnosed. After an emergency anterior cervical corpectomy and fusion 
surgery, she almost completely recovered. Iatrogenic cervical SCI after 
nonspinal surgeries that requires neck hyperextension is rarely reported, 
probably due to underdiagnosis and underreport. Among the 14 cases 
(including ours) published in the literature, most patients had cervical 
spondylosis and were senior men. Five patients had diabetes. Four patients 
had long-term hemodialysis. Seven patients had undergone coronary artery 
bypass surgery that requires prolonged operative time. Only 3 patients had 
almost complete recovery. Most patients were disabled. Two patients required 
tracheostomy for long-term ventilator support. Two patients died. These 
cases reiterate the potential risk of iatrogenic SCI in people with 
predisposing conditions such as cervical spondylosis, especially considering 
the rising prevalence and severity of cervical spondylosis caused by the 
aging of the population and modern sedentary lifestyle. Surgeries requiring 
prolonged neck hyperextension put patients with cervical spondylosis at risk 
for SCI. Failure to recognize the potential occurrence of iatrogenic SCI 
might endanger patients' lives.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spondylosis; quadriplegia; subtotal thyroidectomy; 
EMTREE MEDICAL INDEX TERMS
  adult; anterior cervical corpectomy and fusion; article; asymptomatic disease; brain dysfunction (complication); case report; cervical spondylotic myelopathy; disease course; elective surgery; emergency surgery; female; high risk patient; human; middle aged; nuclear magnetic resonance imaging; priority journal; spinal cord compression (surgery); spinal cord injury (complication, surgery); spine fusion; thyroid nodule (surgery); treatment outcome; whiplash injury; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Endocrinology (3)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015094621
MEDLINE PMID
  25674751 (http://www.ncbi.nlm.nih.gov/pubmed/25674751)
PUI
  L604711835
DOI
  10.1097/MD.0000000000000524
FULL TEXT LINK
  http://dx.doi.org/10.1097/MD.0000000000000524
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15365964&id=doi:10.1097%2FMD.0000000000000524&atitle=Tetraplegia+after+thyroidectomy+in+a+patient+with+cervical+spondylosis+%3A+A+case+report+and+literature+review&stitle=Medicine&title=Medicine+%28United+States%29&volume=94&issue=6&spage=&epage=&aulast=Xiong&aufirst=Wei&auinit=W.&aufull=Xiong+W.&coden=MEDIA&isbn=&pages=-&date=2015&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 365
TITLE
  Open thoracoabdominal aortic repair for chronic type B dissection
AUTHOR NAMES
  Kouchoukos N.T.; Kulik A.; Castner C.F.
AUTHOR ADDRESSES
  (Kouchoukos N.T., ntkouch@aol.com; Castner C.F.) Division of Cardiovascular 
and Thoracic Surgery, Missouri Baptist Medical Center, St Louis, United 
States.
(Kulik A.) Division of Cardiothoracic Surgery, Lynn Heart Institute, Boca 
Raton Regional Hospital, Boca Raton, United States.
CORRESPONDENCE ADDRESS
  N.T. Kouchoukos, Cardiac, Thoracic, and Vascular Surgery, 3009 N. Ballas Rd, 
St Louis, United States.
AiP/IP ENTRY DATE
  2015-03-03
FULL RECORD ENTRY DATE
  2015-03-10
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2015) 149:2 (S125-S129). 
Date of Publication: 1 Feb 2015
VOLUME
  149
ISSUE
  2
FIRST PAGE
  S125
LAST PAGE
  S129
DATE OF PUBLICATION
  1 Feb 2015
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Objectives Advances in endovascular surgery have brought into question the 
role of open operative treatment of chronic thoracoabdominal aortic 
dissection. In this context, we evaluated our experience with open repair of 
this condition using a single operative technique. Methods From January 1986 
to January 2014, 69 patients with chronic thoracoabdominal aortic dissection 
underwent open repair using total cardiopulmonary bypass (CPB) and 
hypothermic circulatory arrest (HCA). The degree of repair was as follows: 
Crawford extent I, 13 patients (19%), Crawford extent II, 41 patients (59%), 
and Crawford extent III, 15 patients (22%). Thirty patients (43%) had Marfan 
or Loeys-Dietz syndrome. Fifty-three patients (77%) had previous operations 
on the thoracic or abdominal aorta. Results The 30-day mortality rate was 
5.8% (4 patients). Stroke occurred in 2 (3%) of 66 operative survivors, and 
spinal cord ischemic injury in 4 (6%). Temporary dialysis for new-onset 
renal failure was required in 4.5% of hospital survivors and tracheostomy in 
10.6%. Survival after 1, 5, and 10 years was 87%, 65%, and 40%, 
respectively. Eighteen patients (26%) required a total of 20 subsequent 
operations on the thoracic or abdominal aorta of whom 15 had Marfan or 
Loeys-Dietz syndrome. Three of these procedures were for contiguous distal 
aortic disease and 10 were for patch aneurysms of the intercostal or 
visceral/renal arteries. Conclusions Open thoracoabdominal aortic repair for 
chronic dissection using CPB and HCA can be accomplished with mortality and 
morbidity rates that are comparable with those reported for endovascular or 
hybrid techniques. Open repair should remain a viable and primary option for 
the management of this condition until the long-term effectiveness of 
alternative methods of treatment is clearly established.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); aortic reconstruction; thoracoabdominal aortic dissection (surgery); thoracoabdominal aortic repair; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cardiopulmonary bypass; cerebrovascular accident; human; Loeys Dietz syndrome; major clinical study; Marfan syndrome; mortality; priority journal; survival rate; survival time; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015776592
MEDLINE PMID
  25212054 (http://www.ncbi.nlm.nih.gov/pubmed/25212054)
PUI
  L602517218
DOI
  10.1016/j.jtcvs.2014.07.064
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2014.07.064
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2014.07.064&atitle=Open+thoracoabdominal+aortic+repair+for+chronic+type+B+dissection&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=149&issue=2&spage=S125&epage=S129&aulast=Kouchoukos&aufirst=Nicholas+T.&auinit=N.T.&aufull=Kouchoukos+N.T.&coden=JTCSA&isbn=&pages=S125-S129&date=2015&auinit1=N&auinitm=T
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 366
TITLE
  Beam Attenuators and the Risk of Unrecognized Large-Fraction Irradiation of 
Critical Tissues
AUTHOR NAMES
  Luka S.; Marks J.E.
AUTHOR ADDRESSES
  (Luka S.; Marks J.E.) Loyola-Hines Department of Radiotherapy, Loyola 
University of Chicago, Stritch School of Medicine, 2160 S. First Avenue, 
Maywood, United States.
CORRESPONDENCE ADDRESS
  S. Luka, Dept. of Radiotherapy, Loyola University Medical Center, 2160 S. 
First Ave., Maywood, United States.
AiP/IP ENTRY DATE
  2016-11-02
FULL RECORD ENTRY DATE
  2017-01-13
SOURCE
  Medical Dosimetry (2015) 19:1 (15-21). Date of Publication: 1 Jan 2015
VOLUME
  19
ISSUE
  1
FIRST PAGE
  15
LAST PAGE
  21
DATE OF PUBLICATION
  1 Jan 2015
ISSN
  1873-4022 (electronic)
  0958-3947
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  The use of radiation beam attenuators led to radiation injury of the spinal 
cord in one patient and of the peripheral nerve in another due to 
unsuspected large-fraction irradiation. The anatomic distribution of 
radiation dose was reconstructed in the sagittal plane for the patient who 
developed radiation myelopathy and in the axial plane for the patient who 
developed peripheral neuropathy. The actual dose delivered to the injured 
structure in each patient was taken from the dose distribution and recorded 
along with the time, number of fractions, and dose per fraction. The patient 
who developed radiation myelopathy received a total of 46.5 Gy in 
twenty-three 2.1 Gy fractions in 31 days to the upper cervical spinal cord 
where the thickness of the neck was less than the central axis thickness due 
to cervical lordosis and absence of a posterior compensating filter. The 
patient who developed peripheral neuropathy received 55 Gy in twenty-five 
2.2 Gy fractions in 50 days to the femoral nerve using bolus over the groins 
and an anterior one-half value layer Cerrobend pelvic block to bias the dose 
anteriorly. Compensating filters and other beam attenuators should be used 
with caution because they may result in unsuspected large-fraction 
irradiation and total doses of radiation that exceed the tolerance of 
critical structures.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); carbamazepine (drug therapy); fluorouracil (adverse drug reaction, drug therapy); ibuprofen (drug therapy); mitomycin (adverse drug reaction, drug therapy); morphine (drug therapy); prednisone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  radiation attenuation; radiation beam; radiation dose fractionation; radiation hazard; radiation injury (complication, diagnosis); radiation myelopathy (complication, diagnosis); radiation neuropathy (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  abdominal pain (complication, side effect); aged; anus carcinoma (drug therapy, radiotherapy); areflexia (complication, diagnosis); arytenoid cartilage; body weight loss; Brown Sequard syndrome (complication, diagnosis); cancer staging; case report; cervical spinal cord; cervical spinal cord injury (complication, diagnosis); Clostridium difficile infection (complication, diagnosis, drug therapy); computer assisted tomography; conference paper; dysphagia (complication); dyspnea (complication); electromyography; erythema (complication); esophageal squamous cell carcinoma (radiotherapy); external beam radiotherapy; female; femoral nerve; fever (complication, side effect); hoarseness (complication); human; inguinal region; kyphosis; lack of drug effect; larynx edema (complication); leukocytosis (complication, side effect); lordosis; lumbar spine; male; muscle weakness (complication, diagnosis); myelography; nerve root compression (complication, diagnosis); neuroimaging; neuromuscular transmission; nuclear magnetic resonance imaging; pain (complication, drug therapy); pain severity; paresthesia (complication); peripheral nerve injury (complication); peripheral neuropathy (complication); pinprick test; priority journal; radiation dose; radiation dose distribution; radiation field; radiation response; radiation tolerance; sensorimotor neuropathy (complication, side effect); sensory dysfunction (complication, diagnosis); skin exfoliation (complication); sore throat (complication); spondylolisthesis (complication, diagnosis); stomach tube; tendon reflex; tracheoesophageal fistula (complication); tracheostomy; treatment duration; vocal cord paralysis (complication); walking difficulty (complication); 
DRUG TRADE NAMES
  motrin
  tegretol
CAS REGISTRY NUMBERS
  carbamazepine (298-46-4, 8047-84-5)
  fluorouracil (51-21-8)
  ibuprofen (15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6)
  mitomycin (1404-00-8, 50-07-7, 74349-48-7)
  morphine (52-26-6, 57-27-2)
  prednisone (53-03-2)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160774169
PUI
  L612935503
DOI
  10.1016/0958-3947(94)90028-0
FULL TEXT LINK
  http://dx.doi.org/10.1016/0958-3947(94)90028-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18734022&id=doi:10.1016%2F0958-3947%2894%2990028-0&atitle=Beam+Attenuators+and+the+Risk+of+Unrecognized+Large-Fraction+Irradiation+of+Critical+Tissues&stitle=Med.+Dosim.&title=Medical+Dosimetry&volume=19&issue=1&spage=15&epage=21&aulast=Luka&aufirst=S.&auinit=S.&aufull=Luka+S.&coden=MEDOE&isbn=&pages=15-21&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 367
TITLE
  Sleep onset hypoventilation in chronic spinal cord injury
AUTHOR NAMES
  Bascom A.T.; Sankari A.; Goshgarian H.G.; Badr M.S.
AUTHOR ADDRESSES
  (Bascom A.T., abascoml@med.wayne.edu; Sankari A.; Badr M.S.) Sleep Research 
Laboratory, John D. Dingell Veterans Affairs Medical Center, Detroit, United 
States.
(Bascom A.T., abascoml@med.wayne.edu; Sankari A.; Goshgarian H.G.; Badr 
M.S.) Wayne State University, School of Medicine, Detroit, United States.
CORRESPONDENCE ADDRESS
  A.T. Bascom, Sleep Research Lab, John D. Dingell VAMC, 4646 John R, Room 
C3411, Detroit, United States. Email: abascoml@med.wayne.edu
AiP/IP ENTRY DATE
  2016-12-23
FULL RECORD ENTRY DATE
  2017-01-11
SOURCE
  Physiological Reports (2015) 3:8 Article Number: e12490. Date of 
Publication: 2015
VOLUME
  3
ISSUE
  8
DATE OF PUBLICATION
  2015
ISSN
  2051-817X (electronic)
BOOK PUBLISHER
  American Physiological Society, subscrip@the-aps.org
ABSTRACT
  A high prevalence of sleep-disordered breathing (SDB) after spinal cord 
injury (SCI) has been reported in the literature; however, the underlying 
mechanisms are not well understood. We sought to determine the effect of the 
withdrawal of the wakefulness drive to breathe on the degree of 
hypoventilation in SCI patients and able-bodied controls. We studied 18 
subjects with chronic cervical and thoracic SCI (10 cervical, 8 thoracic 
SCI; 11 males; age 42.4 ± 17.1 years; body mass index 26.3 ± 4.8 kg/m(2)) 
and 17 matched ablebodied subjects. Subjects underwent polysomnography, 
which included quantitative measurement of ventilation, timing, and upper 
airway resistance (RUA) on a breath-by-breath basis during transitions from 
wake to stage N1 sleep. Compared to able-bodied controls, SCI subjects had a 
significantly greater reduction in tidal volume during the transition from 
wake to N1 sleep (from 0.51 ± 0.21 to 0.32 ± 0.10 L vs. 0.47 ± 0.13 to 0.43 
± 0.12 L; respectively, P < 0.05). Moreover, end-tidal CO(2) and end-tidal 
O(2) were significantly altered from wake to sleep in SCI (38.9 ± 2.7 mmHg 
vs. 40.6 ± 3.4 mmHg; 94.1 ± 7.1 mmHg vs. 91.2 ± 8.3 mmHg; respectively, P < 
0.05), but not in able-bodied controls (39.5 ± 3.2 mmHg vs. 39.9 ± 3.2 mmHg; 
99.4 ± 5.4 mmHg vs. 98.9 ± 6.1 mmHg; respectively, P = ns). R(UA) was not 
significantly altered in either group. In conclusion, individuals with SCI 
experience hypoventilation at sleep onset, which cannot be explained by 
upper airway mechanics. Sleep onset hypoventilation may contribute to the 
development SDB in the SCI population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypoventilation; sleep disordered breathing; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; airway resistance; apnea hypopnea index; article; assisted ventilation; body mass; clinical article; controlled study; electroencephalography; end tidal carbon dioxide tension; female; forced expiratory volume; forced vital capacity; human; human experiment; male; maximal expiratory pressure; peripheral vascular disease; polysomnography; quadriplegia; respiratory function; spirometry; tracheostomy; upper airway resistance syndrome; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160917767
PUI
  L613727917
DOI
  10.14814/phy2.12490
FULL TEXT LINK
  http://dx.doi.org/10.14814/phy2.12490
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2051817X&id=doi:10.14814%2Fphy2.12490&atitle=Sleep+onset+hypoventilation+in+chronic+spinal+cord+injury&stitle=Physiol.+Rep.&title=Physiological+Reports&volume=3&issue=8&spage=&epage=&aulast=Bascom&aufirst=Amy+T.&auinit=A.T.&aufull=Bascom+A.T.&coden=&isbn=&pages=-&date=2015&auinit1=A&auinitm=T
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 368
TITLE
  A case of acute pancreatitis secondary to spinal cord injury
AUTHOR NAMES
  Cao L.; Sun Y.; Lu Z.; Zhang P.; Yin L.; Li H.; Hua T.; Zheng Y.
AUTHOR ADDRESSES
  (Cao L., caolijun_ay@hotmail.com; Sun Y.; Lu Z.; Zhang P.; Yin L.; Li H.; 
Hua T.; Zheng Y.) Department of Critical Care Medicine, Second Affiliated 
Hospital, Anhui Medical University, Hefei, Anhui, China.
CORRESPONDENCE ADDRESS
  L. Cao, Department of Critical Care Medicine, Second Affiliated Hospital, 
Anhui Medical University, Hefei, Anhui, China. Email: 
caolijun_ay@hotmail.com
AiP/IP ENTRY DATE
  2016-03-08
FULL RECORD ENTRY DATE
  2016-03-17
SOURCE
  Neuroendocrinology Letters (2015) 36:5 (407-409). Date of Publication: 2015
VOLUME
  36
ISSUE
  5
FIRST PAGE
  407
LAST PAGE
  409
DATE OF PUBLICATION
  2015
ISSN
  0172-780X
BOOK PUBLISHER
  Maghira and Maas Publications, publisher@nel.edu
ABSTRACT
  Acute pancreatitis (AP) is a frequent and potentially life-threatening 
disease with high morbidity and mortality. The overall mortality of AP is 
approximately 5%. Alcohol consumption and gallstones are the main etiology 
of AP. Hypertriglyceridemia, idiosyncratic reactions to drugs, anatomic 
alterations and ascaris lumbricoides can also give rise to AP. Although 
spinal cord injury (SCI) can cause AP, however, the case of induced by 
cervical spine surgery has not been reported. A 61-year-old man with 
quadriplegic and respiratory distress received cervical spine surgery for 
spinal cervical spondylosis and multi-stage longitudinal ligament. He was 
admitted to intensive care unit (ICU) after tracheotomy for progressive 
dyspnea, one day after the cervical spine surgery. The patient was diagnosed 
with AP, in the absence of any identifiable causes of pancreatitis. He was 
treated with intravenous fluids, no oral feeding, enteral and parenteral 
nutrition, antibiotic and mechanical ventilation. The patient s condition 
gradually improved after the treatment. This case describes a case of 
postoperative cervical spondylosis that led to AP. In this report, we 
highlight the importance of early diagnosis and subsequent appropriate 
treatment. We conclude that the outcome can be favorable, if the treatment 
is appropriate.
EMTREE DRUG INDEX TERMS
  amylase (endogenous compound); antibiotic agent (drug therapy); hemoglobin (endogenous compound); infusion fluid (drug therapy); triacylglycerol lipase (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute pancreatitis (drug therapy, complication, diagnosis, drug therapy, 
etiology); spinal cord injury (prevention); 
EMTREE MEDICAL INDEX TERMS
  abdominal distension; abdominal radiography; adult; amylase blood level; antibiotic therapy; article; artificial ventilation; Babinski reflex; blood pressure measurement; body temperature; breathing rate; case report; cervical spondylosis (surgery); dyspnea; enteric feeding; erythrocyte count; follow up; hemoglobin blood level; hospital admission; human; intensive care unit; leukocyte count; male; middle aged; nuclear magnetic resonance imaging; operative blood loss; parenteral nutrition; pulse rate; quadriplegia; respiratory distress; sensory dysfunction; spine surgery; tracheotomy; triacylglycerol lipase blood level; 
CAS REGISTRY NUMBERS
  amylase (9000-90-2, 9000-92-4, 9001-19-8)
  hemoglobin (9008-02-0)
  triacylglycerol lipase (9001-62-1)
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160182073
MEDLINE PMID
  26707037 (http://www.ncbi.nlm.nih.gov/pubmed/26707037)
PUI
  L608755214
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0172780X&id=doi:&atitle=A+case+of+acute+pancreatitis+secondary+to+spinal+cord+injury&stitle=Neuroendocrinol.+Lett.&title=Neuroendocrinology+Letters&volume=36&issue=5&spage=407&epage=409&aulast=Cao&aufirst=Lijun&auinit=L.&aufull=Cao+L.&coden=NLETD&isbn=&pages=407-409&date=2015&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 369
TITLE
  Recurrent aneurysmal bone cyst of the cervical spine in childhood treated 
with doxycycline injection
AUTHOR NAMES
  Doyle A.; Field A.; Graydon A.
AUTHOR ADDRESSES
  (Doyle A., adoyle@adhb.govt.nz) Radiology with Anatomy, University of 
Auckland, Park Rd, Auckland, New Zealand.
(Field A.; Graydon A.) Orthopaedic Department, Starship Children’s Hospital, 
Auckland District Health Board, Auckland, New Zealand.
(Doyle A., adoyle@adhb.govt.nz) Department of Radiology, Auckland City 
Hospital, Auckland District Health Board, Auckland, New Zealand.
CORRESPONDENCE ADDRESS
  A. Doyle, Radiology with Anatomy, University of Auckland, Park Rd, Auckland, 
New Zealand.
AiP/IP ENTRY DATE
  2014-10-24
FULL RECORD ENTRY DATE
  2015-06-25
SOURCE
  Skeletal Radiology (2015) 44:4 (609-612). Date of Publication: 2015
VOLUME
  44
ISSUE
  4
FIRST PAGE
  609
LAST PAGE
  612
DATE OF PUBLICATION
  2015
ISSN
  1432-2161 (electronic)
  0364-2348
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  A 12-year-old female was treated surgically for an aneurysmal bone cyst of 
the cervical spine involving the C2 and C3 vertebrae. The patient underwent 
surgery twice and further surgery was assessed as unfeasible. Treatment by 
intraosseous injection of doxycycline was uncomplicated and has resulted in 
resolution of the multifocal recurrent disease.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  doxycycline (drug therapy, intraosseous drug administration); 
EMTREE DRUG INDEX TERMS
  iohexol; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysmal bone cyst (drug therapy, drug therapy); cervical spine; childhood disease (drug therapy, drug therapy); spine disease (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  article; bone graft; bone radiography; bone transplantation; cancer radiotherapy; cancer surgery; case report; child; clinical assessment; computer assisted tomography; disease course; dura mater; dysphagia; dyspnea (complication); female; general anesthesia; human; iliac crest; lymphedema (complication); nasogastric tube; neck pain; nuclear magnetic resonance; ossification; postoperative care; postoperative complication (complication); priority journal; rectum anterior resection; recurrent disease; school child; spine surgery; tracheostomy; tumor recurrence; validation study; vertebral artery; 
CAS REGISTRY NUMBERS
  doxycycline (10592-13-9, 17086-28-1, 564-25-0, 94088-85-4)
  iohexol (66108-95-0)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014831888
MEDLINE PMID
  25319562 (http://www.ncbi.nlm.nih.gov/pubmed/25319562)
PUI
  L600179761
DOI
  10.1007/s00256-014-2027-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00256-014-2027-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14322161&id=doi:10.1007%2Fs00256-014-2027-y&atitle=Recurrent+aneurysmal+bone+cyst+of+the+cervical+spine+in+childhood+treated+with+doxycycline+injection&stitle=Skelet.+Radiol.&title=Skeletal+Radiology&volume=44&issue=4&spage=609&epage=612&aulast=Doyle&aufirst=Anthony&auinit=A.&aufull=Doyle+A.&coden=SKRAD&isbn=&pages=609-612&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 370
TITLE
  Neuromuscular Disorders and Sleep in Critically Ill Patients
AUTHOR NAMES
  Irfan M.; Selim B.; Rabinstein A.A.; St Louis E.K.
AUTHOR ADDRESSES
  (Irfan M.; Selim B.; St Louis E.K., StLouis.Erik@mayo.edu) Department of 
Medicine, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 
First Street Southwest, Rochester, United States.
(Irfan M.; Rabinstein A.A.; St Louis E.K., StLouis.Erik@mayo.edu) Department 
of Neurology, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 
200 First Street Southwest, Rochester, United States.
CORRESPONDENCE ADDRESS
  E.K. St Louis, Departments of Neurology and Medicine, Mayo Center for Sleep 
Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, 
United States.
AiP/IP ENTRY DATE
  2015-07-27
FULL RECORD ENTRY DATE
  2015-07-29
SOURCE
  Critical Care Clinics (2015) 31:3 (533-550). Date of Publication: 1 Jul 2015
VOLUME
  31
ISSUE
  3
FIRST PAGE
  533
LAST PAGE
  550
DATE OF PUBLICATION
  1 Jul 2015
ISSN
  1557-8232 (electronic)
  0749-0704
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Sleep-disordered breathing (SDB) is a frequent presenting manifestation of 
neuromuscular disorders and can lead to significant morbidity and mortality. 
If not recognized and addressed early in the clinical course, SDB can lead 
to clinical deterioration with respiratory failure. The pathophysiologic 
basis of SDB in neuromuscular disorders, clinical features encountered in 
specific neuromuscular diseases, and diagnostic and management strategies 
for SDB in neuromuscular patients in the critical care setting are reviewed. 
Noninvasive positive pressure ventilation has been a crucial advance in 
critical care management, improving sleep quality and often preventing or 
delaying mechanical ventilation and improving survival in neuromuscular 
patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  critically ill patient; neuromuscular disease; sleep disordered breathing (diagnosis, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; botulism; central sleep apnea syndrome (diagnosis); comorbidity; critical illness; Duchenne muscular dystrophy; Eaton Lambert syndrome (diagnosis); endotracheal intubation; fascioscapulohumeral dystrophy; Guillain Barre syndrome; human; hypoventilation; Kennedy disease; limb girdle muscular dystrophy; lung function test; metabolic myopathy; mitochondrial encephalomyopathy; morbidity; mortality; muscular dystrophy; myasthenia gravis (diagnosis); myopathy; myositis; myotonic dystrophy; noninvasive ventilation; polysomnography; positive end expiratory pressure; postpoliomyelitis syndrome; priority journal; REM sleep; review; spinal cord injury; symptom; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015210793
MEDLINE PMID
  26118919 (http://www.ncbi.nlm.nih.gov/pubmed/26118919)
PUI
  L605276099
DOI
  10.1016/j.ccc.2015.03.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ccc.2015.03.007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15578232&id=doi:10.1016%2Fj.ccc.2015.03.007&atitle=Neuromuscular+Disorders+and+Sleep+in+Critically+Ill+Patients&stitle=Crit.+Care+Clin.&title=Critical+Care+Clinics&volume=31&issue=3&spage=533&epage=550&aulast=Irfan&aufirst=Muna&auinit=M.&aufull=Irfan+M.&coden=CCCLE&isbn=&pages=533-550&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 371
TITLE
  Feeding patients with tracheostomies
AUTHOR NAMES
  McRae J.; Fox R.; Morgan S.
AUTHOR ADDRESSES
  (McRae J., j.mcrae@ucl.ac.uk; Fox R.; Morgan S.) London Spinal Cord Injury 
Centre, Royal National Orthopaedic Hospital, Stanmore, United Kingdom.
CORRESPONDENCE ADDRESS
  J. McRae, London Spinal Cord Injury Centre, Royal National Orthopaedic 
Hospital, Stanmore, United Kingdom.
AiP/IP ENTRY DATE
  2015-10-28
FULL RECORD ENTRY DATE
  2015-10-29
SOURCE
  Journal of the Intensive Care Society (2015) 16:2 (180). Date of 
Publication: 1 May 2015
VOLUME
  16
ISSUE
  2
FIRST PAGE
  180
DATE OF PUBLICATION
  1 May 2015
ISSN
  1751-1437
BOOK PUBLISHER
  SAGE Publications Inc., claims@sagepub.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  cervical spinal cord injury; clinical decision making; critically ill patient; dysphagia; human; larynx; letter; nasogastric tube; speech therapy; swallowing; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2015455044
PUI
  L606506491
DOI
  10.1177/1751143715569022
FULL TEXT LINK
  http://dx.doi.org/10.1177/1751143715569022
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17511437&id=doi:10.1177%2F1751143715569022&atitle=Feeding+patients+with+tracheostomies&stitle=J.+Intensive+Care+Soc.&title=Journal+of+the+Intensive+Care+Society&volume=16&issue=2&spage=180&epage=&aulast=McRae&aufirst=Jackie&auinit=J.&aufull=McRae+J.&coden=&isbn=&pages=180-&date=2015&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 372
TITLE
  An instrument approach to airway management
AUTHOR NAMES
  Thomson D.P.; Braude D.; High K.; Miller-Tester R.
AUTHOR ADDRESSES
  (Thomson D.P., Thomsonda@ecu.edu) Department of Emergency Medicine, Brody 
School of Medicine, East Carolina University, Greenville, United States.
(Braude D.) Department of Emergency Medicine, University of New Mexico, 
Albuquerque, United States.
(High K.) Department of Emergency Medicine/Emergency Services, Vanderbilt 
University, Medical Center, Nashville, United States.
(Miller-Tester R.) IFR Global, Inc., Murfreesboro, United States.
CORRESPONDENCE ADDRESS
  D.P. Thomson, Department of Emergency Medicine, Brody School of Medicine, 
East Carolina University, Greenville, United States.
AiP/IP ENTRY DATE
  2015-07-01
FULL RECORD ENTRY DATE
  2015-07-09
SOURCE
  Air Medical Journal (2015) 34:2 (113-116). Date of Publication: 2015
VOLUME
  34
ISSUE
  2
FIRST PAGE
  113
LAST PAGE
  116
DATE OF PUBLICATION
  2015
ISSN
  1532-6497 (electronic)
  1067-991X
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Aviation terminology and thought processes are commonly applied to medicine. 
We further propose the adaptation of instrument flight terminology to 
emergency airway management including the aviation approach plate visual aid 
and replacement of the term "failed airway" with "missed airway,"
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aviation; emergency airway management; emergency care; practice guideline; respiration control; 
EMTREE MEDICAL INDEX TERMS
  airway creation device; airway obstruction; article; assisted ventilation; emergency health service; endotracheal intubation; head injury; health care personnel; human; hypercapnia; hypocapnia; hypoxemia; laryngoscopy; manual emergency ventilator; morbidity; mortality; oxygenation; patient positioning; positive end expiratory pressure; priority journal; resuscitation; spinal cord injury; survival; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015159376
MEDLINE PMID
  25733119 (http://www.ncbi.nlm.nih.gov/pubmed/25733119)
PUI
  L605006534
DOI
  10.1016/j.amj.2014.12.011
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.amj.2014.12.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15326497&id=doi:10.1016%2Fj.amj.2014.12.011&atitle=An+instrument+approach+to+airway+management&stitle=Air+Med.+J.&title=Air+Medical+Journal&volume=34&issue=2&spage=113&epage=116&aulast=Thomson&aufirst=David+P.&auinit=D.P.&aufull=Thomson+D.P.&coden=AMJIA&isbn=&pages=113-116&date=2015&auinit1=D&auinitm=P
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 373
TITLE
  Influences of chronic obstructive pulmonary disease on outcomes of total 
arch replacement
AUTHOR NAMES
  Miyahara S.; Nakai H.; Izawa N.; Yamanaka K.; Sakamoto T.; Nomura Y.; Inoue T.; Matsumori M.; Okada K.; Okita Y.
AUTHOR ADDRESSES
  (Miyahara S.; Nakai H.; Izawa N.; Yamanaka K.; Sakamoto T.; Nomura Y.; Inoue 
T.; Matsumori M.; Okada K.; Okita Y., yokita@med.kobe-u.ac.jp) Department of 
Surgery, Division of Cardiovascular Surgery, Kobe University Graduate School 
of Medicine, Kobe, Japan.
CORRESPONDENCE ADDRESS
  Y. Okita, Department of Surgery, Division of Cardiovascular Surgery, Kobe 
University Graduate School of Medicine, Kobe, Japan.
AiP/IP ENTRY DATE
  2015-01-15
FULL RECORD ENTRY DATE
  2015-01-22
SOURCE
  Annals of Thoracic Surgery (2015) 99:1 (72-78). Date of Publication: 1 Jan 
2015
VOLUME
  99
ISSUE
  1
FIRST PAGE
  72
LAST PAGE
  78
DATE OF PUBLICATION
  1 Jan 2015
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background Although an association between chronic obstructive pulmonary 
disease (COPD) and adverse surgical outcomes has been proposed, the impact 
of COPD severity on postoperative outcomes remains unclear. Our objective 
was to analyze the prognostic implication of COPD severity on outcomes after 
total aortic arch replacement. Methods Between October 1999 and December 
2012, 269 patients undergoing total arch replacement through median 
sternotomy, who were elective cases with preoperative spirometry records, 
were retrospectively reviewed. Patients were divided into four groups: 
control group, with ratio of forced expiratory volume of air in 1 second 
(FEV(1)) to forced vital capacity (FVC) of 70% or greater; mild airflow 
obstruction, with FEV(1)/FVC ratio less than 70% and FEV(1) 80% or greater 
of predicted; moderate airflow obstruction, FEV(1)/FVC ratio less than 70% 
and FEV(1) 50% to 79% of predicted; severe airflow obstruction, FEV(1)/FVC 
ratio less than 70% and FEV(1) less than 50% of predicted. Symptoms of 
functional dyspnea and disability were also assessed. Multivariate logistic 
and Cox regression methods were used to determine if there was an 
independent association between COPD and short-term and long-term outcomes, 
respectively. Results The in-hospital mortality rate was 2.2% (6 of 269). A 
consistent trend of increasing frequency of postoperative respiratory 
complications with advanced airflow obstruction was noted. In multivariate 
analysis, in-hospital mortality (p = 0.022), incidence of respiratory 
complications (p = 0.021) and overall mortality (p = 0.025) was 
significantly associated with the symptoms of COPD, respectively. 
Conclusions The severity of COPD as defined by spirometry and symptoms of 
functional dyspnea may be an important prognostic marker of patients 
undergoing total arch replacement.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic arch surgery; chronic obstructive lung disease (etiology); 
EMTREE MEDICAL INDEX TERMS
  aged; airway obstruction (complication); aortic reconstruction; article; atrial fibrillation (complication); brain hemorrhage (complication); breathing disorder (complication); cerebrovascular accident (complication); controlled study; death; disability (complication); disease severity; dyspnea (complication); female; forced expiratory volume; forced vital capacity; heart arrest (complication); heart muscle ischemia (complication); hemodialysis; hoarseness (complication); human; incidence; intestine necrosis (complication); Japan; kidney failure (complication); major clinical study; male; mediastinitis (complication); morbidity; mortality; multiple organ failure (complication); neurological complication (complication); outcome assessment; pneumonia (complication); postoperative complication (complication); prevalence; priority journal; prognosis; recurrent laryngeal nerve palsy (complication); respiratory function; retrospective study; sepsis (complication); smoking; spinal cord injury (complication); spirometry; sternotomy; surgical mortality; thoracoabdominal aortic replacement; trachea stoma; tracheostomy; transient neurologic deficit (complication); tympanic temperature; vocal cord paralysis (complication); wound infection (complication); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  General Pathology and Pathological Anatomy (5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015658959
MEDLINE PMID
  25440266 (http://www.ncbi.nlm.nih.gov/pubmed/25440266)
PUI
  L601176314
DOI
  10.1016/j.athoracsur.2014.08.031
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2014.08.031
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2014.08.031&atitle=Influences+of+chronic+obstructive+pulmonary+disease+on+outcomes+of+total+arch+replacement&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=99&issue=1&spage=72&epage=78&aulast=Miyahara&aufirst=Shunsuke&auinit=S.&aufull=Miyahara+S.&coden=ATHSA&isbn=&pages=72-78&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 374
TITLE
  Spinal muscular atrophy associated with progressive myoclonic epilepsy: A 
rare condition caused by mutations in ASAH1
AUTHOR NAMES
  Rubboli G.; Veggiotti P.; Pini A.; Berardinelli A.; Cantalupo G.; Bertini E.; Tiziano F.D.; D'Amico A.; Piazza E.; Abiusi E.; Fiori S.; Pasini E.; Darra F.; Gobbi G.; Michelucci R.
AUTHOR ADDRESSES
  (Rubboli G., guru@filadelfia.dk) Danish Epilepsy Center, 
Filadelfia/University of Copenhagen, Kolonivej 1, Dianalund, Denmark.
(Rubboli G., guru@filadelfia.dk; Pasini E.; Michelucci R.) Neurology Unit, 
Bellaria Hospital, IRCCS Institute of Neurological Sciences, Bologna, Italy.
(Veggiotti P.) Department of Brain and Behavioral Sciences, IRCCS C. Mondino 
National Neurological Institute, University of Pavia, Pavia, Italy.
(Pini A.; Gobbi G.) Child Neurology Unit, Bellaria Hospital, IRCCS Institute 
of Neurological Sciences, Bologna, Italy.
(Berardinelli A.; Piazza E.) Child Neuropsychiatry Unit, IRCCS C. Mondino 
National Neurological Institute, Pavia, Italy.
(Cantalupo G.; Darra F.) Department of Life and Reproduction Sciences, 
University of Verona, Verona, Italy.
(Bertini E.; D'Amico A.) IRCCS Laboratory of Molecular Medicine, Bambino 
Gesu' Children's Research Hospital, Rome, Italy.
(Tiziano F.D.; Abiusi E.; Fiori S.) Medical Genetics Institute, Catholic 
University, Rome, Italy.
CORRESPONDENCE ADDRESS
  G. Rubboli, Danish Epilepsy Center, Filadelfia/University of Copenhagen, 
Kolonivej 1, Dianalund, Denmark.
AiP/IP ENTRY DATE
  2015-04-10
FULL RECORD ENTRY DATE
  2015-06-02
SOURCE
  Epilepsia (2015) 56:5 (692-698). Date of Publication: 1 May 2015
VOLUME
  56
ISSUE
  5
FIRST PAGE
  692
LAST PAGE
  698
DATE OF PUBLICATION
  1 May 2015
ISSN
  1528-1167 (electronic)
  0013-9580
BOOK PUBLISHER
  Blackwell Publishing Inc., subscrip@blackwellpub.com
ABSTRACT
  Objective To present the clinical features and the results of laboratory 
investigations in three patients with spinal muscular atrophy associated 
with progressive myoclonic epilepsy (SMA-PME), a rare condition caused by 
mutations in the N-acylsphingosine amidohydrosilase 1 (ASAH1) gene. Methods 
The patients were submitted to clinical evaluation, neurophysiologic 
investigations (that included wakefulness and sleep electroencephalography 
[EEG], video-polygraphic recording with jerk-locked back-averaging, 
multimodal evoked potentials, and electromyography), brain magnetic 
resonance imaging (MRI), biochemical screening, muscle and skin biopsies, 
and molecular genetic analysis. Results The main clinical features were 
onset in childhood with proximal muscular weakness, generalized epilepsy 
with absences and myoclonic seizures, cognitive impairment of variable 
degree; the course was progressive with muscle wasting and uncontrolled 
epileptic seizures. In one patient, earlier onset before the age of 2 years 
was associated with a more complex clinical picture, with abnormal eye 
movements, progressive cognitive impairment, and a more rapid and severe 
course. EEG/polygraphic data were consistent with PME, demonstrating 
generalized spike-and-wave discharges, evidence of positive and negative 
myoclonia, and prominent photosensitivity. In one patient, transcranial 
magnetic stimulation showed a hyperexcitable motor cortex, whereas 
somatosensory evoked potentials were unaffected. Possible involvement of the 
central acoustic and visual pathways was suggested by abnormal auditory and 
visual evoked potentials. Muscle biopsies showed typical signs of neurogenic 
damage. Molecular genetic analysis showed mutations of the ASAH1 gene. 
Significance Our data indicate that SMA-PME associated with ASAH1 mutations 
is a genetically distinct condition with specific clinical and 
neurophysiologic features. Further studies are warranted to explore the role 
of the ASAH1 gene in muscle and brain function.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ceramide (endogenous compound); n acylsphingosine amidohydrosilase 1 (endogenous compound); 
EMTREE DRUG INDEX TERMS
  barbituric acid derivative (drug therapy); clonazepam (drug combination, drug therapy); creatine kinase (endogenous compound); ethosuximide (drug combination, drug therapy); etiracetam (drug combination, drug therapy); felbamate (drug combination, drug therapy); glucosaminidase (endogenous compound); lamotrigine (drug combination, drug therapy); lorazepam (drug combination, drug therapy); lysosome enzyme (endogenous compound); mitochondrial DNA (endogenous compound); piracetam (drug therapy); unclassified drug; valproic acid (drug combination, drug therapy); zonisamide (drug combination, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gene mutation; myoclonus epilepsy (drug therapy, drug therapy, etiology); spinal muscular atrophy (etiology); 
EMTREE MEDICAL INDEX TERMS
  absence; adult; anticonvulsant therapy; article; ataxic gait; auditory evoked potential; biochemical analysis; brain function; bronchus secretion; case report; child; clinical evaluation; clinical feature; cognitive defect; disease association; drug megadose; dyskinesia; dysphagia; electroencephalogram; electroencephalography; electromyography; epileptic discharge; eye movement disorder; fasciculation; female; frameshift mutation; gait disorder; gene expression assay; generalized epilepsy; genetic analysis; Griffiths Mental Development scale; human; hypotrophy; intelligence quotient; lung infection; mental development; mental development assessment; missense mutation; molecular genetics; motor cortex; motor performance; multichannel recorder; muscle atrophy; muscle biopsy; muscle function; muscle weakness; myoclonus; myoclonus seizure; neuroimaging; neurologic disease; neurologic examination; neurophysiological monitoring; neuropsychological test; nonsense mutation; nuclear magnetic resonance imaging; onset age; percutaneous endoscopic gastrostomy; photosensitivity; preschool child; priority journal; real time polymerase chain reaction; school child; scoliosis; seizure; skin biopsy; somatosensory evoked potential; spike wave; tongue disease; tongue fasciculation; tonic clonic seizure; tracheostomy; transcranial magnetic stimulation; uncontrolled epileptic seizure; visual evoked potential; visual system; wakefulness; 
CAS REGISTRY NUMBERS
  clonazepam (1622-61-3)
  creatine kinase (9001-15-4)
  ethosuximide (77-67-8)
  etiracetam (102767-28-2, 33996-58-6)
  felbamate (25451-15-4)
  lamotrigine (84057-84-1)
  lorazepam (846-49-1)
  piracetam (7491-74-9)
  valproic acid (1069-66-5, 99-66-1)
  zonisamide (68291-97-4)
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Drug Literature Index (37)
  Epilepsy Abstracts (50)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015893843
MEDLINE PMID
  25847462 (http://www.ncbi.nlm.nih.gov/pubmed/25847462)
PUI
  L603580379
DOI
  10.1111/epi.12977
FULL TEXT LINK
  http://dx.doi.org/10.1111/epi.12977
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281167&id=doi:10.1111%2Fepi.12977&atitle=Spinal+muscular+atrophy+associated+with+progressive+myoclonic+epilepsy%3A+A+rare+condition+caused+by+mutations+in+ASAH1&stitle=Epilepsia&title=Epilepsia&volume=56&issue=5&spage=692&epage=698&aulast=Rubboli&aufirst=Guido&auinit=G.&aufull=Rubboli+G.&coden=EPILA&isbn=&pages=692-698&date=2015&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 375
TITLE
  Severe transient pharyngeal paralysis following C2 fracture repair
AUTHOR NAMES
  Cumpston E.C.; Bock J.M.
AUTHOR ADDRESSES
  (Cumpston E.C.; Bock J.M., jbock@mcw.edu) Division of Laryngology and 
Professional Voice, Department of Otolaryngology and Communication Sciences, 
Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, United 
States.
CORRESPONDENCE ADDRESS
  J.M. Bock, Division of Laryngology and Professional Voice, Department of 
Otolaryngology and Communication Sciences, Medical College of Wisconsin, 
9200 W Wisconsin Ave, Milwaukee, United States.
AiP/IP ENTRY DATE
  2015-10-13
FULL RECORD ENTRY DATE
  2015-10-16
SOURCE
  Annals of Otology, Rhinology and Laryngology (2015) 124:8 (598-602). Date of 
Publication: 1 Jan 2015
VOLUME
  124
ISSUE
  8
FIRST PAGE
  598
LAST PAGE
  602
DATE OF PUBLICATION
  1 Jan 2015
ISSN
  0003-4894
BOOK PUBLISHER
  SAGE Publications Inc., claims@sagepub.com
ABSTRACT
  Objectives: We report a case of isolated pharyngeal plexus injury following 
posterior plating of a C2 fracture in an 84-year-old white male. Methods: 
Methods include a case report with literature review. Results: The patient 
presented with dense pharyngeal paralysis and inability to initiate 
swallowing but maintained true vocal cord movement. The patient required 
gastrostomy tube feeding for 3 months but eventually recovered his 
swallowing function. Prior literature on acute pharyngeal paralysis 
following upper cervical spine fracture repairs is reviewed with 
recommendations for care of this unique patient population. Conclusions: 
Traumatic C2 fracture repair can lead to isolated dense pharyngeal paralysis 
due to pharyngeal plexus injury with subsequent severe dysphagia. 
Observation may be appropriate in this population, with consideration of 
tracheotomy for recurrent aspiration.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  odontoid process fracture (therapy); paralysis (complication); pharyngeal paralysis (complication); pharynx disease (complication); 
EMTREE MEDICAL INDEX TERMS
  aged; article; aspiration pneumonia; bone screw (adverse device effect); case report; cervical collar; computer assisted tomography; coughing; dysphagia (complication); dysphonia; falling; fever; hospital readmission; human; male; nuclear magnetic resonance imaging; percutaneous endoscopic gastrostomy; posterior spine fusion; priority journal; recurrent aspiration; swallowing; thorax radiography; very elderly; vocal cord; vocal cord paralysis (complication); voice disorder (complication); 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015428127
MEDLINE PMID
  25653253 (http://www.ncbi.nlm.nih.gov/pubmed/25653253)
PUI
  L606306318
DOI
  10.1177/0003489415570938
FULL TEXT LINK
  http://dx.doi.org/10.1177/0003489415570938
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034894&id=doi:10.1177%2F0003489415570938&atitle=Severe+transient+pharyngeal+paralysis+following+C2+fracture+repair&stitle=Ann.+Otol.+Rhinol.+Laryngol.&title=Annals+of+Otology%2C+Rhinology+and+Laryngology&volume=124&issue=8&spage=598&epage=602&aulast=Cumpston&aufirst=Evan+C.&auinit=E.C.&aufull=Cumpston+E.C.&coden=AORHA&isbn=&pages=598-602&date=2015&auinit1=E&auinitm=C
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 376
TITLE
  International guidelines for the management and treatment of Morquio a 
syndrome
AUTHOR NAMES
  Hendriksz C.J.; Berger K.I.; Giugliani R.; Harmatz P.; Kampmann C.; Mackenzie W.G.; Raiman J.; Villarreal M.S.; Savarirayan R.
AUTHOR ADDRESSES
  (Hendriksz C.J., Chris.Hendriksz@srft.nhs.uk) Salford Royal NHS Foundation 
Trust, Salford, United Kingdom.
(Berger K.I.) New York University School of Medicine, New York, United 
States.
(Giugliani R.) Department of Genetics/UFRGS and INAGEMP, Medical Genetics 
Service/HCPA, Porto Alegrw, RS, Brazil.
(Harmatz P.) University of California San Francisco Benioff Children's 
Hospital Oakland, Oakland, United States.
(Kampmann C.) University Children's Hospital, Mainz, Germany.
(Mackenzie W.G.) Nemours/Alfred I. duPont Hospital for Children, Wilmington, 
United States.
(Raiman J.) Hospital for Sick Children, Toronto, Canada.
(Villarreal M.S.) Fundacion Cardioinfantil, Bogotá C/marca, Colombia.
(Savarirayan R.) Murdoch Childrens Research Institute and University of 
Melbourne, Parkville, Australia.
CORRESPONDENCE ADDRESS
  C.J. Hendriksz, Transitional Metabolic Medicine, Manchester Academic Health 
Science Centre, The Mark Holland Metabolic Unit, Salford Royal Foundation 
NHS Trust, Ladywell NW2-2nd Floor, Salford, Manchester, United Kingdom.
AiP/IP ENTRY DATE
  2015-01-28
FULL RECORD ENTRY DATE
  2015-01-29
SOURCE
  American Journal of Medical Genetics, Part A (2015) 167:1 (11-25). Date of 
Publication: 1 Jan 2015
VOLUME
  167
ISSUE
  1
FIRST PAGE
  11
LAST PAGE
  25
DATE OF PUBLICATION
  1 Jan 2015
ISSN
  1552-4833 (electronic)
  1552-4825
BOOK PUBLISHER
  Wiley-Liss Inc., info@wiley.com
ABSTRACT
  Morquio A syndrome (mucopolysaccharidosis IVA) is a lysosomal storage 
disorder associated with skeletal and joint abnormalities and significant 
non-skeletal manifestations including respiratory disease, spinal cord 
compression, cardiac disease, impaired vision, hearing loss, and dental 
problems. The clinical presentation, onset, severity and progression rate of 
clinical manifestations of Morquio A syndrome vary widely between patients. 
Because of the heterogeneous and progressive nature of the disease, the 
management of patients with Morquio A syndrome is challenging and requires a 
multidisciplinary approach, involving an array of specialists. The current 
paper presents international guidelines for the evaluation, treatment and 
symptom-based management of Morquio A syndrome. These guidelines were 
developed during two expert meetings by an international panel of 
specialists in pediatrics, genetics, orthopedics, pulmonology, cardiology, 
and anesthesia with extensive experience in managing Morquio A syndrome.
EMTREE DRUG INDEX TERMS
  bronchodilating agent (drug therapy); dipeptidyl carboxypeptidase inhibitor (drug therapy); elosulfase alfa (clinical trial, drug comparison - placebo, drug therapy, 
intravenous drug administration); fluoride; influenza vaccine (drug therapy); placebo; Pneumococcus vaccine (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health care planning; Morquio syndrome (drug therapy, diagnosis, disease management, drug therapy, 
prevention, surgery, therapy); practice guideline; 
EMTREE MEDICAL INDEX TERMS
  abdominal disease (surgery); anesthesia; body growth; cardiovascular disease (surgery); clinical classification; dental procedure; disease association; drug efficacy; endurance; enzyme replacement; eye disease (therapy); eye surgery; health care delivery; health care personnel; hearing aid; hearing impairment; heart valve replacement; human; musculoskeletal disease (surgery, therapy); neurologic disease; orthopedic surgery; pain; patient care; patient monitoring; perioperative period; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); physical examination; physiotherapy; positive end expiratory pressure; priority journal; quality of life; respiratory tract disease (drug therapy, prevention, surgery, therapy); review; risk assessment; spinal cord decompression; stomach surgery; tooth disease (therapy); tracheostomy; treatment duration; treatment indication; vaccination; 
CAS REGISTRY NUMBERS
  fluoride (16984-48-8)
EMBASE CLASSIFICATIONS
  Ophthalmology (12)
  Public Health, Social Medicine and Epidemiology (17)
  Human Genetics (22)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014625159
MEDLINE PMID
  25346323 (http://www.ncbi.nlm.nih.gov/pubmed/25346323)
PUI
  L601042565
DOI
  10.1002/ajmg.a.36833
FULL TEXT LINK
  http://dx.doi.org/10.1002/ajmg.a.36833
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15524833&id=doi:10.1002%2Fajmg.a.36833&atitle=International+guidelines+for+the+management+and+treatment+of+Morquio+a+syndrome&stitle=Am.+J.+Med.+Genet.+Part+A&title=American+Journal+of+Medical+Genetics%2C+Part+A&volume=167&issue=1&spage=11&epage=25&aulast=Hendriksz&aufirst=Christian+J.&auinit=C.J.&aufull=Hendriksz+C.J.&coden=AJMGD&isbn=&pages=11-25&date=2015&auinit1=C&auinitm=J
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 377
TITLE
  A novel role for otolaryngologists in the multidisciplinary difficult airway 
response team
AUTHOR NAMES
  Hillel A.T.; Pandian V.; Mark L.J.; Clark J.; Miller C.R.; Haut E.R.; Cover R.; Berkow L.C.; Agrawal Y.; Bhatti N.
AUTHOR ADDRESSES
  (Hillel A.T.; Clark J.; Agrawal Y.; Bhatti N.) Department of 
Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, 
United States.
(Mark L.J.; Miller C.R.) Department of Anesthesiology and Critical Care 
Medicine, Johns Hopkins Hospital, Baltimore, United States.
(Pandian V., vpandia1@jhmi.edu; Haut E.R.; Berkow L.C.) Department of 
Surgery, Johns Hopkins Hospital, Baltimore, United States.
(Cover R.) Legal Department, Johns Hopkins Hospital, Baltimore, United 
States.
CORRESPONDENCE ADDRESS
  V. Pandian, Department of Anesthesia and Critical Care Medicine, 600 N. 
Wolfe Street, Baltimore, United States.
AiP/IP ENTRY DATE
  2015-03-03
FULL RECORD ENTRY DATE
  2015-03-10
SOURCE
  Laryngoscope (2015) 125:3 (640-644). Date of Publication: 1 Mar 2015
VOLUME
  125
ISSUE
  3
FIRST PAGE
  640
LAST PAGE
  644
DATE OF PUBLICATION
  1 Mar 2015
ISSN
  1531-4995 (electronic)
  0023-852X
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Objectives/Hypothesis: The Difficult Airway Response Team (DART) was 
implemented in July 2008 to address emergent difficult airway situations. 
The main objective of this study was to highlight the unique role and skill 
set that otolaryngologists bring and their impact on patient outcomes. Study 
Design: Retrospective review of prospectively collected data from the 
hospital's airway registry. Methods: We collected data on demographics, 
airway characteristics, airway management techniques used by each specialty, 
and clinical outcomes (such as cricothyrotomies) for patients for whom a 
code was activated between July 2006 and June 2010. We compared data between 
pre- and post-DART cohorts and between DART and non-DART patients using a 
matched case-control approach. Results: Of the 2,826 codes, 90 patients 
required DART management between July 2008 and June 2010. Body mass index, 
cervical spine injury/fixation, history of difficult airway, head and neck 
mass, and oropharyngeal and/or supraglottic angioedema were identified as 
significant predictors for DART activation. Forty-nine (60%) patients' 
airways were secured by anesthesiologists, 30 (36%) by otolaryngologists, 
and three (4%) by trauma surgeons. Otolaryngologists were able to use 
specialized techniques such as Holinger and Dedo laryngoscopes to 
significantly decrease the number of cricothyrotomies from seven (0.73%) 
pre-DART implementation to four (0.21%) post-DART implementation. 
Conclusions: Otolaryngologists were able to decrease the need for 
cricothyrotomies using specialized techniques for patients with difficult 
airways. Otolaryngologists bring a special skill set to the DART that is 
beyond the scope of anesthesiologists and trauma surgeons and that can 
improve patient outcomes by preventing unnecessary emergency surgical 
airways.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  otolaryngologist; professional practice; rapid response team; respiration control; 
EMTREE MEDICAL INDEX TERMS
  adult; airway constriction; ambulatory care; anesthesist; angioneurotic edema; article; body mass; cervical spine injury; cohort analysis; comparative study; controlled study; female; general condition; head and neck tumor; human; intensive care unit; laryngoscope; major clinical study; male; medical history; middle aged; morbid obesity; nasotracheal intubation; oropharyngeal angioedema; priority journal; professional competence; retrospective study; supraglottic angioedema; tracheotomy; videolaryngoscope; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015776569
MEDLINE PMID
  25251732 (http://www.ncbi.nlm.nih.gov/pubmed/25251732)
PUI
  L602517082
DOI
  10.1002/lary.24949
FULL TEXT LINK
  http://dx.doi.org/10.1002/lary.24949
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15314995&id=doi:10.1002%2Flary.24949&atitle=A+novel+role+for+otolaryngologists+in+the+multidisciplinary+difficult+airway+response+team&stitle=Laryngoscope&title=Laryngoscope&volume=125&issue=3&spage=640&epage=644&aulast=Hillel&aufirst=Alexander+T.&auinit=A.T.&aufull=Hillel+A.T.&coden=LARYA&isbn=&pages=640-644&date=2015&auinit1=A&auinitm=T
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 378
TITLE
  Intubations and airway management: An overview of Hassles through third 
millennium
AUTHOR NAMES
  Alanazi A.
AUTHOR ADDRESSES
  (Alanazi A., abdanazi@yahoo.com) Department of Pediatric Emergency, College 
of Applied Medical Sciences, King Saud Bin Abdul-Aziz University for Health 
Sciences, Riyadh, Saudi Arabia.
CORRESPONDENCE ADDRESS
  A. Alanazi, Department of Pediatric Emergency, College of Applied Medical 
Sciences, King Saud Bin Abdul-Aziz University for Health Sciences, Riyadh, 
Saudi Arabia.
AiP/IP ENTRY DATE
  2015-05-07
FULL RECORD ENTRY DATE
  2015-05-25
SOURCE
  Journal of Emergencies, Trauma and Shock (2015) 8:2 (99-107). Date of 
Publication: 1 Apr 2015
VOLUME
  8
ISSUE
  2
FIRST PAGE
  99
LAST PAGE
  107
DATE OF PUBLICATION
  1 Apr 2015
ISSN
  0974-519X (electronic)
  0974-2700
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Background: The placement of a tube into a patient's trachea "the 
intubation" as we call is not as simple as it looks. It is a very tricky and 
tedious maneuver that entails skills to assess and perform. Nevertheless, 
often this is left to the chores of inefficient hands due to a paucity of 
the availability of experts. They seldom are able to complete the task and 
often wind up calling the attention of the unit. The present review is an 
attempt to describe the need to undertake intubation, the procedures and 
techniques, the complications, including morbidity and mortality and airway 
management. This overview includes explicit descriptions of the difficult 
airway which represents multifaceted interface amid patient factors, 
clinical setting, and skills of the practitioner. Materials and Methods: To 
accomplish the target, peer-reviewed English language articles published 
during third millennium up to 2013 were selected from Pub Med, Pub Med 
Central, Science Direct, Up-to-date, Med Line, comprehensive databases, 
Cochrane library, and the Internet (Google, Yahoo). Review of Literature: 
The review constituted a systematic search of literature on the requirements 
that necessitate the practice of intubation, different techniques that 
facilitate easy conduct of procedure, the complications, including, 
morbidity and mortality, and the airway management. Conclusion: Recording 
every single detail has been beyond the scope of this review, however; some 
aspects have been wrapped up in nutshell. Some areas of the review are too 
basic which the medics are well aware of and knowledgeable. Nevertheless, 
these are difficult to be dispensed with in consideration of their source to 
the awareness of a common man and a great majority of the patients.
EMTREE DRUG INDEX TERMS
  2 propanol; anesthetic agent; chloroxylenol; epinephrine; ketamine (drug therapy); neurotoxin; phenol derivative; phenytoin; quetiapine; salbutamol; topiramate; vegetable oil; ziprasidone; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intubation; respiration control; 
EMTREE MEDICAL INDEX TERMS
  acute heart infarction (complication); airway obstruction; article; artificial ventilation; asthma (drug therapy); brain injury; bronchoscopy; cerebrovascular accident (complication); cervical spinal cord injury; childhood cancer; chronic obstructive lung disease; coma; congenital diaphragm hernia; croup; double lumen tube; drug exposure; drug intoxication; early intervention; echography; emergency; endotracheal intubation; endotracheal stent; endotracheal tube; esophagus cancer; esophagus obturator; Glasgow coma scale; hemoptysis; human; laryngeal mask; laryngeal tube; laryngoscopy; lymph node metastasis; myxedema; newborn disease; obesity; physician; priority journal; respiratory tract injury (complication); skill; subglottic stenosis (complication); therapy delay; thoracotomy; thorax drainage; thyroid carcinoma; tracheostomy; tracheotomy; ventilator associated pneumonia (complication); 
DEVICE MANUFACTURERS
  King Pharmaceutical
CAS REGISTRY NUMBERS
  2 propanol (67-63-0)
  adrenalin (51-43-4, 55-31-2, 6912-68-1)
  chloroxylenol (1321-23-9, 88-04-0)
  ketamine (1867-66-9, 6740-88-1, 81771-21-3)
  neurotoxin (39386-17-9)
  phenytoin (57-41-0, 630-93-3)
  quetiapine (111974-72-2)
  salbutamol (18559-94-9, 35763-26-9)
  topiramate (97240-79-4)
  ziprasidone (118289-78-4, 122883-93-6, 138982-67-9, 199191-69-0)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015995878
PUI
  L604111174
DOI
  10.4103/0974-2700.145401
FULL TEXT LINK
  http://dx.doi.org/10.4103/0974-2700.145401
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0974519X&id=doi:10.4103%2F0974-2700.145401&atitle=Intubations+and+airway+management%3A+An+overview+of+Hassles+through+third+millennium&stitle=J.+Emerg.+Trauma+Shock&title=Journal+of+Emergencies%2C+Trauma+and+Shock&volume=8&issue=2&spage=99&epage=107&aulast=Alanazi&aufirst=Abdullah&auinit=A.&aufull=Alanazi+A.&coden=&isbn=&pages=99-107&date=2015&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 379
TITLE
  Conflicts of interest in orthopaedic surgery: The intertwining of 
orthopaedic surgery, peer review publications and corporate sponsorship
AUTHOR NAMES
  Dhillon K.S.
AUTHOR ADDRESSES
  (Dhillon K.S.) KPJ Selangor, Specialist Hospital, Shah Alam, Malaysia.
CORRESPONDENCE ADDRESS
  K.S. Dhillon, Nur Azree Ferdaus Bin Kamudin, No. 513 Jalan 17/20, Petaling 
Jaya, Malaysia.
AiP/IP ENTRY DATE
  2015-06-30
FULL RECORD ENTRY DATE
  2015-07-02
SOURCE
  Malaysian Orthopaedic Journal (2015) 9:1 (47-59). Date of Publication: 2015
VOLUME
  9
ISSUE
  1
FIRST PAGE
  47
LAST PAGE
  59
DATE OF PUBLICATION
  2015
ISSN
  1985-2533
BOOK PUBLISHER
  Malaysian Orthopaedic Association, moa-publications@moa.home.com
ABSTRACT
  Conflicts of interest in medicine has created deep concerns about the 
integrity of medicine and raised doubts about the trustworthiness of the 
medical professional. New stories of conflict of interest in medicine have 
become a commonplace. The interactions between the medical professional and 
the biomedical device as well as the pharmaceutical industry has become so 
pervasive that the primary interest of the medical professional in 
protecting and promoting the welfare of the patient has been compromised. 
The professional judgement and actions have been influenced by secondary 
interests, the major fungible and quantifiable being financial interest. The 
industry influence not only affects the way we practice orthopaedics but 
also affects medical education and peer review publications. Peer review 
publications have been shown to exaggerate benefits of the industry products 
while at the same time downplaying the risks. These conflicts of interest in 
orthopaedic surgery are particularly common in spinal and joint replacement 
surgery where joint replacement has been described as a ‘fashion trade’. The 
introduction of new products appears to be an uncontrolled experiment which 
has been hijacked by large corporations. This article explores the unhealthy 
pervasive interaction between the orthopaedic surgeon and the medical 
devices as well as the pharmaceutical industry. It highlights how the 
biomedical and the pharmaceutical industry dominate all aspects of the 
healthcare system. With its wealth and political clout, its influence is 
present everywhere, from the use of devices and drugs, research, 
publications, trials, education and even formulation of CGPs.
EMTREE DRUG INDEX TERMS
  bone morphogenetic protein 2 (endogenous compound); celecoxib (drug therapy); cyclooxygenase 2 (endogenous compound); cyclooxygenase 2 inhibitor (drug therapy); nonsteroid antiinflammatory agent (drug therapy); prostacyclin; rofecoxib (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  orthopedic surgery; 
EMTREE MEDICAL INDEX TERMS
  arthroplasty; article; bone development; controlled clinical trial (topic); drug industry; dysphagia; health economics; hoarseness; human; joint prosthesis; medical device; multicenter study (topic); osteoarthritis (drug therapy); osteolysis; practice guideline; spinal cord injury; spine surgery; systematic review (topic); tracheotomy; urine retention; 
DRUG TRADE NAMES
  celebrex
  ketorolac
  oxycodone
  pregablin
  vioxx
CAS REGISTRY NUMBERS
  celecoxib (169590-42-5)
  prostacyclin (35121-78-9, 61849-14-7)
  rofecoxib (162011-90-7, 186912-82-3)
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015154138
PUI
  L604978301
DOI
  10.5704/MOJ.1503.008
FULL TEXT LINK
  http://dx.doi.org/10.5704/MOJ.1503.008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19852533&id=doi:10.5704%2FMOJ.1503.008&atitle=Conflicts+of+interest+in+orthopaedic+surgery%3A+The+intertwining+of+orthopaedic+surgery%2C+peer+review+publications+and+corporate+sponsorship&stitle=Malays.+Orthop.+J.&title=Malaysian+Orthopaedic+Journal&volume=9&issue=1&spage=47&epage=59&aulast=Dhillon&aufirst=K.S.&auinit=K.S.&aufull=Dhillon+K.S.&coden=&isbn=&pages=47-59&date=2015&auinit1=K&auinitm=S
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 380
TITLE
  Acute Onset of Guillain-Barré Syndrome after Elective Spinal Surgery
AUTHOR NAMES
  Boghani Z.; Livingston A.D.; Simpson E.P.; Holman P.J.; Grossman R.G.
AUTHOR ADDRESSES
  (Boghani Z.; Livingston A.D.; Holman P.J.; Grossman R.G., 
rgrossman@houstonmethodist.org) Department of Neurosurgery, Houston 
Methodist Hospital, Neurological Institute, Houston, United States.
(Simpson E.P.) Department of Neurology, Houston Methodist Hospital, 
Neurological Institute, Houston, United States.
CORRESPONDENCE ADDRESS
  R.G. Grossman, Department of Neurosurgery, Houston Methodist Hospital, 
Neurological Institute, Houston, United States.
AiP/IP ENTRY DATE
  2015-06-08
FULL RECORD ENTRY DATE
  2015-08-17
SOURCE
  World Neurosurgery (2015) 84:2 (376-379). Date of Publication: 1 Aug 2015
VOLUME
  84
ISSUE
  2
FIRST PAGE
  376
LAST PAGE
  379
DATE OF PUBLICATION
  1 Aug 2015
ISSN
  1878-8769 (electronic)
  1878-8750
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background Guillain-Barré syndrome (GBS) is an acute peripheral neuropathy 
caused by an autoimmune response against myelin of peripheral nerves. GBS 
has been reported after surgery, in general, and after spinal surgery, in 
particular. In most cases, GBS developed 1-3 weeks after surgery. Methods 
Report of 2 cases of GBS after elective spine surgery that developed in the 
immediate postoperative period. Results Within 1 and 3 hours after surgery, 
respectively, both patients developed ascending loss of motor and sensory 
function. They were taken back urgently to the operating room for wound 
exploration to ensure that an epidural hematoma had not developed. 
Cerebrospinal fluid studies and electromyography/nerve conduction velocity 
were then rapidly obtained and were compatible with acute inflammatory 
demyelinating polyradiculoneuropathy. Therapy was initiated with 
administration of intravenous immunoglobulin and plasmapheresis. Both 
patients made substantial motor recovery during the course of 1-2 years but 
have residual sensory abnormalities. Conclusions GBS developing acutely 
after spinal surgery is a rare occurrence but should be considered in the 
differential diagnosis of neurological deterioration after surgery. Rapid 
diagnosis and treatment are essential for recovery of neurological function.
EMTREE DRUG INDEX TERMS
  ganglioside GM1 antibody (endogenous compound); immunoglobulin (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute disease; elective surgery; Guillain Barre syndrome (etiology, surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  acute inflammatory demyelinating polyradiculoneuropathy (diagnosis); adult; antibody titer; article; case report; cerebrospinal fluid; cervical spine; discectomy; echography; electromyography; electrophoresis; epidural hematoma; foraminotomy; hospital admission; hospitalization; human; immunotherapy; laminectomy; leg pain; lumbar puncture; lumbar spine; male; middle aged; motor performance; nerve conduction; nerve decompression; neurologic examination; nuclear magnetic resonance imaging; operating room; peripheral neuropathy; peroneus nerve paralysis; personal experience; plasmapheresis; polyradiculoneuropathy (diagnosis); postoperative period; prostatectomy; protein cerebrospinal fluid level; radicular pain; sedation; subdural hematoma; tracheostomy; urine incontinence; wound closure; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Immunology, Serology and Transplantation (26)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015087817
MEDLINE PMID
  25836269 (http://www.ncbi.nlm.nih.gov/pubmed/25836269)
PUI
  L604646487
DOI
  10.1016/j.wneu.2015.03.036
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.wneu.2015.03.036
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18788769&id=doi:10.1016%2Fj.wneu.2015.03.036&atitle=Acute+Onset+of+Guillain-Barr%C3%A9+Syndrome+after+Elective+Spinal+Surgery&stitle=World+Neurosurg.&title=World+Neurosurgery&volume=84&issue=2&spage=376&epage=379&aulast=Boghani&aufirst=Zain&auinit=Z.&aufull=Boghani+Z.&coden=&isbn=&pages=376-379&date=2015&auinit1=Z&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 381
TITLE
  Hyperacute onset of guillain barre syndrome in the immediate postpartum 
period following Caesarean section under spinal anaesthesia
AUTHOR NAMES
  Vinay B.; Sonia B.; Bhadrinarayan V.
AUTHOR ADDRESSES
  (Vinay B.) Department of Anaesthesia, SAKRA World Hospital, National 
Institute of Mental Health and Neurosciences, Bengaluru, India.
(Sonia B., rashibpgi@yahoo.co.in; Bhadrinarayan V.) Department of 
Neuroanaesthesia, National Institute of Mental Health and Neurosciences, 
Bengaluru, India.
CORRESPONDENCE ADDRESS
  B. Sonia, Department of Neuroanaesthesia, National Institute of Mental 
Health and Neurosciences, Bengaluru, India.
AiP/IP ENTRY DATE
  2015-06-22
FULL RECORD ENTRY DATE
  2015-06-24
SOURCE
  Indian Journal of Anaesthesia (2015) 59:6 (391-392). Date of Publication: 1 
Jun 2015
VOLUME
  59
ISSUE
  6
FIRST PAGE
  391
LAST PAGE
  392
DATE OF PUBLICATION
  1 Jun 2015
ISSN
  0019-5049
BOOK PUBLISHER
  Indian Society of Anaesthetists, Flat No 12/1A K Point, 68-BAPC Roy Road, 
Kolkata, India.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cesarean section; Guillain Barre syndrome (diagnosis); puerperium; spinal anesthesia; 
EMTREE MEDICAL INDEX TERMS
  adult; albuminocytological dissociation; case report; cerebrospinal fluid examination; clinical feature; dissociation; epidural hematoma; female; human; hyperreflexia; letter; limited mobility; muscle strength; myelitis; poliomyelitis; quadriplegia; sensory nerve conduction; tracheostomy; young adult; 
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2015129952
PUI
  L604876625
DOI
  10.4103/0019-5049.158782
FULL TEXT LINK
  http://dx.doi.org/10.4103/0019-5049.158782
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00195049&id=doi:10.4103%2F0019-5049.158782&atitle=Hyperacute+onset+of+guillain+barre+syndrome+in+the+immediate+postpartum+period+following+Caesarean+section+under+spinal+anaesthesia&stitle=Indian+J.+Anaesth.&title=Indian+Journal+of+Anaesthesia&volume=59&issue=6&spage=391&epage=392&aulast=Vinay&aufirst=Byrappa&auinit=B.&aufull=Vinay+B.&coden=&isbn=&pages=391-392&date=2015&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 382
TITLE
  A cluster of acute flaccid paralysis and cranial nerve dysfunction 
temporally associated with an outbreak of enterovirus D68 in children in 
Colorado, USA
AUTHOR NAMES
  Messacar K.; Schreiner T.L.; Maloney J.A.; Wallace A.; Ludke J.; Oberste M.S.; Nix W.A.; Robinson C.C.; Glodé M.P.; Abzug M.J.; Dominguez S.R.
AUTHOR ADDRESSES
  (Messacar K.; Glodé M.P.; Abzug M.J.; Dominguez S.R., 
samuel.dominguez@childrenscolorado.org) Department of Pediatric Infectious 
Diseases, Children's Hospital Colorado, University of Colorado School of 
Medicine, Aurora, United States.
(Messacar K.; Schreiner T.L.) Department of Hospital Medicine, Children's 
Hospital Colorado, University of Colorado School of Medicine, Aurora, United 
States.
(Wallace A.; Ludke J.) Department of Child Neurology, Children's Hospital 
Colorado, University of Colorado School of Medicine, Aurora, United States.
(Maloney J.A.) Department of Radiology, Children's Hospital Colorado, 
University of Colorado School of Medicine, Aurora, United States.
(Robinson C.C.) Pathology and Laboratory Medicine, Children's Hospital 
Colorado, University of Colorado School of Medicine, Aurora, United States.
(Oberste M.S.; Nix W.A.) Division of Viral Diseases, National Center for 
Immunization and Respiratory Diseases, Centers for Disease Control and 
Prevention, Atlanta, United States.
CORRESPONDENCE ADDRESS
  S.R. Dominguez, Department of Pediatric Infectious Diseases, Children's 
Hospital Colorado, University of Colorado School of Medicine, Aurora, United 
States.
AiP/IP ENTRY DATE
  2015-02-06
FULL RECORD ENTRY DATE
  2015-07-09
SOURCE
  The Lancet (2015) 385:9978 (1662-1671). Date of Publication: 2015
VOLUME
  385
ISSUE
  9978
FIRST PAGE
  1662
LAST PAGE
  1671
DATE OF PUBLICATION
  2015
ISSN
  1474-547X (electronic)
  0140-6736
BOOK PUBLISHER
  Lancet Publishing Group, cususerv@lancet.com
ABSTRACT
  Background: Clusters of acute flaccid paralysis or cranial nerve dysfunction 
in children are uncommon. We aimed to assess a cluster of children with 
acute flaccid paralysis and cranial nerve dysfunction geographically and 
temporally associated with an outbreak of enterovirus-D68 respiratory 
disease. Methods: We defined a case of neurological disease as any child 
admitted to Children's Hospital Colorado (Aurora, CO, USA) with acute 
flaccid paralysis with spinal-cord lesions involving mainly grey matter on 
imaging, or acute cranial nerve dysfunction with brainstem lesions on 
imaging, who had onset of neurological symptoms between Aug 1, 2014, and Oct 
31, 2014. We used Poisson regression to assess whether the numbers of cases 
during the outbreak period were significantly greater than baseline case 
numbers from a historical control period (July 31, 2010, to July 31, 2014). 
Findings: 12 children met the case definition (median age 11.5 years [IQR 
6.75-15]). All had a prodromal febrile illness preceding neurological 
symptoms by a median of 7 days (IQR 5.75-8). Neurological deficits included 
flaccid limb weakness (n=10; asymmetric n=7), bulbar weakness (n=6), and 
cranial nerve VI (n=3) and VII (n=2) dysfunction. Ten (83%) children had 
confluent, longitudinally extensive spinal-cord lesions of the central grey 
matter, with predominant anterior horn-cell involvement, and nine (75%) 
children had brainstem lesions. Ten (91%) of 11 children had cerebrospinal 
fluid pleocytosis. Nasopharyngeal specimens from eight (73%) of 11 children 
were positive for rhinovirus or enterovirus. Viruses from five (45%) of 11 
children were typed as enterovirus D68. Enterovirus PCR of cerebrospinal 
fluid, blood, and rectal swabs, and tests for other causes, were negative. 
Improvement of cranial nerve dysfunction has been noted in three (30%) of 
ten children. All ten children with limb weakness have residual deficits. 
Interpretation: We report the first geographically and temporally defined 
cluster of acute flaccid paralysis and cranial nerve dysfunction in children 
associated with an outbreak of enterovirus-D68 respiratory illness. Our 
findings suggest the possibility of an association between enterovirus D68 
and neurological disease in children. If enterovirus-D68 infections continue 
to happen in an endemic or epidemic pattern, development of effective 
antiviral or immunomodulatory therapies and vaccines should become 
scientific priorities.
EMTREE DRUG INDEX TERMS
  immunoglobulin G1 (intravenous drug administration); methylprednisolone (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood disease (epidemiology); cranial nerve paralysis (epidemiology); enterovirus D68 infection (epidemiology); Enterovirus infection (epidemiology); epidemic (epidemiology); flaccid paralysis (epidemiology); 
EMTREE MEDICAL INDEX TERMS
  anterior horn cell; article; central gray matter; child; clinical article; disease association; Enterovirus; gastrostomy; human; International Classification of Diseases; medical record review; patient history of heart transplantation; plasmapheresis; pleocytosis; positive end expiratory pressure; priority journal; school child; tracheostomy; treatment duration; United States; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015710103
MEDLINE PMID
  25638662 (http://www.ncbi.nlm.nih.gov/pubmed/25638662)
PUI
  L601971772
DOI
  10.1016/S0140-6736(14)62457-0
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0140-6736(14)62457-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1474547X&id=doi:10.1016%2FS0140-6736%2814%2962457-0&atitle=A+cluster+of+acute+flaccid+paralysis+and+cranial+nerve+dysfunction+temporally+associated+with+an+outbreak+of+enterovirus+D68+in+children+in+Colorado%2C+USA&stitle=Lancet&title=The+Lancet&volume=385&issue=9978&spage=1662&epage=1671&aulast=Messacar&aufirst=Kevin&auinit=K.&aufull=Messacar+K.&coden=LANCA&isbn=&pages=1662-1671&date=2015&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 383
TITLE
  Chromobacterium haemolyticum pneumonia possibly due to the aspiration of 
runoff water
AUTHOR NAMES
  Takenaka R.; Nureki S.-I.; Ueno T.; Shigemitsu O.; Miyazaki E.; Kadota J.-I.; Miki T.; Okada N.
AUTHOR ADDRESSES
  (Takenaka R.; Nureki S.-I., nureki@oita-u.ac.jp; Kadota J.-I.) Department of 
Respiratory Medicine and Infectious Diseases, Japan.
(Takenaka R.; Shigemitsu O.) Department of Emergency Medicine, Japan.
(Miyazaki E.) Center for Community Medicine, Japan.
(Ueno T.) Clinical Laboratory Center of Oita University Hospital, Japan.
(Miki T.; Okada N.) Department of Microbiology, School of Pharmacology, 
Kitasato University, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  S.-I. Nureki, Department of Respiratory Medicine and Infectious Diseases, 
1-1 Idaigaoka, Hasama-machi, Yufu, Japan. Email: nureki@oita-u.ac.jp
AiP/IP ENTRY DATE
  2015-11-27
FULL RECORD ENTRY DATE
  2015-12-01
SOURCE
  Japanese Journal of Infectious Diseases (2015) 68:6 (526-529). Date of 
Publication: 20 Nov 2015
VOLUME
  68
ISSUE
  6
FIRST PAGE
  526
LAST PAGE
  529
DATE OF PUBLICATION
  20 Nov 2015
ISSN
  1884-2836 (electronic)
  1344-6304
BOOK PUBLISHER
  National Institute of Health, jjid@nih.go.jp
ABSTRACT
  Here, we report a case of pneumonia possibly caused by the aspiration of 
runoff water containing Chromobacterium haemolyticum. A 69-year-old man 
became intoxicatedwithalcohol,fell into a ditch, and lost consciousness 
after suffering a blow to the head. The lower half of his body was 
completely paralyzed because of damage to his spinal cord, and he aspirated 
runoff water from the ditch. Chest computed tomography scans revealed 
consolidation in the right upper lobe and bilateral lower lobes. A sputum 
culture detected gram-negative bacteria that was identified as C. 
haemolyticum. Antibacterial chemotherapy was initiated, and the clinical 
course was favorable. To the best of our knowledge, this is the first report 
of C. haemolyticum pneumonia in the literature.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  runoff; 
EMTREE DRUG INDEX TERMS
  meropenem (adverse drug reaction, drug therapy); piperacillin plus tazobactam (drug therapy, intravenous drug administration); sultamicillin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aspiration pneumonia (drug therapy, diagnosis, drug therapy); Chromobacterium haemolyticum pneumonia (drug therapy, diagnosis, drug 
therapy, surgery); pneumonia (drug therapy, diagnosis, drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; alcohol intoxication; article; artificial ventilation; bacterium identification; cardiopulmonary arrest; case report; Chromobacterium violaceum; computer assisted tomography; consciousness disorder; coughing; drug eruption (side effect); fever; human; male; minimum inhibitory concentration; paralysis; polymerase chain reaction; pulsed field gel electrophoresis; sputum culture; thorax radiography; tracheotomy; 
CAS REGISTRY NUMBERS
  meropenem (96036-03-2)
  sultamicillin (76497-13-7)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015530592
MEDLINE PMID
  26073729 (http://www.ncbi.nlm.nih.gov/pubmed/26073729)
PUI
  L607010522
DOI
  10.7883/yoken.JJID.2014.285
FULL TEXT LINK
  http://dx.doi.org/10.7883/yoken.JJID.2014.285
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18842836&id=doi:10.7883%2Fyoken.JJID.2014.285&atitle=Chromobacterium+haemolyticum+pneumonia+possibly+due+to+the+aspiration+of+runoff+water&stitle=Jpn.+J.+Infect.+Dis.&title=Japanese+Journal+of+Infectious+Diseases&volume=68&issue=6&spage=526&epage=529&aulast=Takenaka&aufirst=Ryuichi&auinit=R.&aufull=Takenaka+R.&coden=JJIDF&isbn=&pages=526-529&date=2015&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 384
TITLE
  A patient with refractory shock induced by several factors, including 
obstruction because of a posterior mediastinal hematoma
AUTHOR NAMES
  Obinata M.; Ishikawa K.; Osaka H.; Mishima K.; Omori K.; Oode Y.; Yanagawa Y.
AUTHOR ADDRESSES
  (Obinata M.; Ishikawa K.; Osaka H.; Mishima K.; Omori K.; Oode Y.; Yanagawa 
Y., yyanaga@juntendo.ac.jp) Department of Acute Critical Care Medicine, 
Shizuoka Hospital, Juntendo University, Japan.
CORRESPONDENCE ADDRESS
  Y. Yanagawa, Nagaoka Izunokuni city, Shizuoka, Japan.
AiP/IP ENTRY DATE
  2015-01-20
FULL RECORD ENTRY DATE
  2015-06-25
SOURCE
  American Journal of Emergency Medicine (2015) 33:6 (859.e1-e859.e2). Date of 
Publication: 1 Jun 2015
VOLUME
  33
ISSUE
  6
FIRST PAGE
  859.e1
LAST PAGE
  e859.e2
DATE OF PUBLICATION
  1 Jun 2015
ISSN
  1532-8171 (electronic)
  0735-6757
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  A 44-year-old man who drove a motorcycle experienced a collision with the 
side of another motorcycle. Because he had sustained a highenergy injury to 
the spinal cord, he was transferred to our hospital. His circulation was 
unstable, and received tracheal intubation in addition to thoracostomy for 
the hemothorax. Whole-body computed tomography (CT) revealed multiple 
fractures, right hemopneumothorax with pulmonary contusion, and minor liver 
injury. After infusing 5000 mL of lactated Ringer's solution and 10 units of 
blood, his circulation remained unstable. On a repeat CT examination, the 
left atriumwas found to be compressed by a posterior mediastinal hematoma 
induced by the fracture of the thoracic spine, and a diagnosis of shock 
induced by multiple factors, including hemorrhagic, neurogenic, and 
obstructive mechanisms, was made. After obtaining stable circulation and 
respirations, internal fixation of the extremities and extubation were 
performed on the 12th hospital day. Chest CT performed on the 27th day 
showed the disappearance of compression of the left atrium by the hematoma.
EMTREE DRUG INDEX TERMS
  contrast medium; dopamine; noradrenalin; Ringer lactate solution; vasopressin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hematoma; mediastinum disease; posterior mediastinal hematoma; refractory shock; shock; 
EMTREE MEDICAL INDEX TERMS
  adult; article; aspiration; atelectasis; blood transfusion; case report; clavicle fracture; compression; computer assisted tomography; conservative treatment; elevated blood pressure; endotracheal intubation; exercise tolerance; extubation; fibula fracture; forward heart failure; heart tamponade; hematopneumothorax; hematothorax; human; hypovolemia; intensive care unit; liver injury; lung contusion; male; multiple trauma; osteosynthesis; positive end expiratory pressure; priority journal; quadriplegia; respiratory function; rib fracture; shoulder fracture; spinal cord injury; spine injury; systolic blood pressure; tension pneumothorax; thorax drainage; tracheostomy; traffic accident; whole body CT; 
CAS REGISTRY NUMBERS
  dopamine (51-61-6, 62-31-7)
  noradrenalin (1407-84-7, 51-41-2)
  Ringer lactate solution (8022-63-7)
  vasopressin (11000-17-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015662445
MEDLINE PMID
  25572646 (http://www.ncbi.nlm.nih.gov/pubmed/25572646)
PUI
  L601244973
DOI
  10.1016/j.ajem.2014.12.027
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ajem.2014.12.027
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15328171&id=doi:10.1016%2Fj.ajem.2014.12.027&atitle=A+patient+with+refractory+shock+induced+by+several+factors%2C+including+obstruction+because+of+a+posterior+mediastinal+hematoma&stitle=Am.+J.+Emerg.+Med.&title=American+Journal+of+Emergency+Medicine&volume=33&issue=6&spage=859.e1&epage=e859.e2&aulast=Obinata&aufirst=Mariko&auinit=M.&aufull=Obinata+M.&coden=AJEME&isbn=&pages=859.e1-e859.e2&date=2015&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 385
TITLE
  Mechanical insufflation-exsufflation: Practice patterns among respiratory 
therapists in Ontario
AUTHOR NAMES
  Prevost S.; Brooks D.; Bwititi P.T.
AUTHOR ADDRESSES
  (Prevost S., prevosts@tbh.net) St Joseph's Hospital, Thunder Bay, Canada.
(Brooks D.) Department of Physical Therapy, University of Toronto, Canada.
(Bwititi P.T.) MAIMS, Australia.
(Bwititi P.T.) FIBMS, United Kingdom.
(Bwititi P.T.) DMLM, United Kingdom.
(Bwititi P.T.) School of Biomedical Sciences, Charles Sturt University, 
Wagga Wagga, Australia.
CORRESPONDENCE ADDRESS
  S. Prevost, St Joseph's Hospital, 35 North Algoma Street, Thunder Bay, 
Canada.
AiP/IP ENTRY DATE
  2015-08-11
FULL RECORD ENTRY DATE
  2015-08-13
SOURCE
  Canadian Journal of Respiratory Therapy (2015) 51:2 (33-38). Date of 
Publication: 2015
VOLUME
  51
ISSUE
  2
FIRST PAGE
  33
LAST PAGE
  38
DATE OF PUBLICATION
  2015
ISSN
  2368-6820 (electronic)
  1205-9838
BOOK PUBLISHER
  Canadian Society of Respiratory Therapists, pubs@cma.ca
ABSTRACT
  BACKGROUND: The mechanical insufflator-exsufflator (MIE) is effective in 
assisting cough and in helping to avoid unplanned hospitalizations, 
tracheostomy and long-term ventilation in patients with neuromuscular 
disease or spinal cord injury. Despite this, the availability and usage of 
the device in Canada is unknown. OBJECTIVE: To investigate practice patterns 
and availability of the MIE in Ontario hospitals. METHODS: A 
cross-sectional, self-administered mail survey was sent to a random sample 
of 400 respiratory therapists practicing in 96 Ontario hospitals. RESULTS: A 
total of 114 (28%) completed surveys were returned from 62 (65%) hospitals. 
Twenty (32%) hospitals had a MIE. The respiratory therapist was the 
predominant health care provider using the MIE. The device was most commonly 
used in the intensive care unit, and medical/ surgical units in patients 
with neuromuscular diseases or spinal cord injuries. Optimal pressure spans 
of 35 cmH<inf>2</inf>O to 40 cmH<inf>2</inf>O were used by 54% of 
respondents. Fourteen of the 20 hospitals with an MIE had policies or 
guidelines in place, and four of these hospitals had established staff 
competencies. Measurements of peak cough flow, maximal 
inspiratory/expiratory pressure and vital capacity were reported to be 
infrequently performed. CONCLUSIONS: The present study demonstrated that the 
MIE device is not widely available in Ontario hospitals and there are 
variations in how the devices are applied, possibly resulting in suboptimal 
therapy. A comprehensive educational program about MIE devices that 
incorporates best practices and a practical component is recommended for 
current providers as well as for inclusion in student curricula.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aeration; artificial ventilation; mechanical insufflation exsufflation; medical practice; respiratory therapist; 
EMTREE MEDICAL INDEX TERMS
  adult; amyotrophic lateral sclerosis (therapy); article; atelectasis (therapy); bronchiectasis (therapy); Canada; chronic obstructive lung disease (therapy); coughing; cross-sectional study; cystic fibrosis (therapy); female; Guillain Barre syndrome (therapy); health care policy; human; intensive care unit; lung fibrosis (therapy); male; middle aged; multicenter study; muscular dystrophy (therapy); neuromuscular disease (therapy); practice guideline; random sample; spinal cord injury (therapy); vital capacity; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  2015251941
PUI
  L605513863
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23686820&id=doi:&atitle=Mechanical+insufflation-exsufflation%3A+Practice+patterns+among+respiratory+therapists+in+Ontario&stitle=Can.+J.+Resp.+Ther.&title=Canadian+Journal+of+Respiratory+Therapy&volume=51&issue=2&spage=33&epage=38&aulast=Prevost&aufirst=Shelley&auinit=S.&aufull=Prevost+S.&coden=CJRTF&isbn=&pages=33-38&date=2015&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 386
TITLE
  Development and validation of a risk prediction model for tracheostomy in 
acute traumatic cervical spinal cord injury patients
AUTHOR NAMES
  Hou Y.F.; Lv Y.; Zhou F.; Tian Y.; Ji H.Q.; Zhang Z.S.; Guo Y.
AUTHOR ADDRESSES
  (Hou Y.F., houyf@bjmu.edu.cn; Lv Y., lvy@bjmu.edu.cn; Zhou F., 
zhouf@bjmu.edu.cn; Tian Y., tiany@bjmu.edu.cn; Ji H.Q., jihq@bjmu.edu.cn; 
Zhang Z.S., zhangzs@bjmu.edu.cn; Guo Y., drguoy@bjmu.edu.cn) Orthopedic 
Trauma, Peking University Third Hospital, No 49, North Garden Rd, Haidian 
District, Beijing, China.
CORRESPONDENCE ADDRESS
  F. Zhou, Orthopedic Trauma, Peking University Third Hospital, No 49, North 
Garden Rd, Haidian District, Beijing, China.
AiP/IP ENTRY DATE
  2015-01-05
SOURCE
  European Spine Journal (2014) . Date of Publication: 27 Dec 2014
DATE OF PUBLICATION
  27 Dec 2014
ISSN
  1432-0932 (electronic)
  0940-6719
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Purpose: Tracheostomy may become indispensable for patients with acute 
traumatic cervical spinal cord injuries. However, the early prediction of a 
tracheostomy is often difficult. Previous prediction models using the 
pulmonary function test (PFT) have limitations because some severely injured 
patients could not provide acceptable PFT results. We aim to develop an 
alternative model for predicting tracheostomy using accessible data obtained 
from the bedside.Method: Clinical, neurological and radiological data from 
345 consecutive patients with acute tetraplegia were retrospectively 
reviewed. We applied multiple logistic regression analysis (MLRA) and 
classification and regression tree (CART) analysis to develop the prediction 
model for tracheostomy. By train-test cross-validation, we used the 
sensitivity, specificity, area under the receiver operating characteristics 
curve (AUC) and correction rate to evaluate the performance of these 
models.Results: According to the American Spinal Injury Association (ASIA) 
standards, an admission ASIA motor score (AAMS) ≤ 22, ASIA grade A and 
presence of respiratory complications were identified as independent 
predictors of tracheostomy by both models. The model derived by CART 
suggested that the highest signal change (HSC) in the spinal cord on 
magnetic resonance imaging (MRI) also affected a patient’s requirement for a 
tracheostomy, while MLRA demonstrated that tracheostomy was also influenced 
by the presence of an ASIA grade B injury. The CART model had a sensitivity 
of 73.7 %, specificity of 89.7 %, AUC of 0.909 and overall correction rate 
of 87.3 %. The sensitivity, specificity, AUC and correction rate of the MLRA 
model were 81.8, 86.4, 0.889 and 85.7 %, respectively.Conclusions: We 
suggest using the CART model in clinical applications. Patients with AAMS ≤ 
1 exhibit an increased likelihood of requiring a tracheostomy. For patients 
with an AAMS in the range of 2–22, surgeons should consider giving these 
patients a tracheostomy once respiratory complications occur. Surgeons 
should be cautious to give a tracheostomy to patients with an AAMS ≥ 23, if 
the patient experiences an incomplete spinal cord injury and the HSC in the 
spinal cord is at C3 level or lower based on MRI. For other patients, close 
observation is necessary; generally, patients with complete SCI might 
require a tracheostomy more frequently.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; human; model; patient; prediction; risk; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  American; American Spinal Injury Association impairment scale; classification; injury; logistic regression analysis; lung function test; multivariate logistic regression analysis; nuclear magnetic resonance imaging; quadriplegia; receiver operating characteristic; spinal cord; spinal cord injury; spine injury; surgeon; tree; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015635512
MEDLINE PMID
  25542384 (http://www.ncbi.nlm.nih.gov/pubmed/25542384)
PUI
  L601082700
DOI
  10.1007/s00586-014-3731-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-014-3731-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-014-3731-y&atitle=Development+and+validation+of+a+risk+prediction+model+for+tracheostomy+in+acute+traumatic+cervical+spinal+cord+injury+patients&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=&issue=&spage=&epage=&aulast=Hou&aufirst=Yun+Fei&auinit=Y.F.&aufull=Hou+Y.F.&coden=ESJOE&isbn=&pages=-&date=2014&auinit1=Y&auinitm=F
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 387
TITLE
  Endoscopic transnasal odontoidectomy without resection of nasal turbinates: 
Clinical outcomes of 13 patients
AUTHOR NAMES
  Yen Y.-S.; Chang P.-Y.; Huang W.-C.; Wu J.-C.; Liang M.-L.; Tu T.-H.; Cheng H.
AUTHOR ADDRESSES
  (Yen Y.-S.; Chang P.-Y.; Huang W.-C.; Wu J.-C., jauching@gmail.com; Liang 
M.-L.; Tu T.-H.; Cheng H.) Neural Re Generation Center, Department of 
Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, No. 
201, Shih-Pai Rd., Sec. 2, Peitou, Taipei, Taiwan.
(Yen Y.-S.; Chang P.-Y.; Huang W.-C.; Wu J.-C., jauching@gmail.com; Liang 
M.-L.; Tu T.-H.; Cheng H.) School of Medicine, National Yang-Ming 
University, Taipei, Taiwan.
(Cheng H.) Institute of Pharmacology, National Yang-Ming University, Taipei, 
Taiwan.
CORRESPONDENCE ADDRESS
  J.-C. Wu, Neural Re Generation Center, Department of Neurosurgery, 
Neurological Institute, Taipei Veterans General Hospital, No. 201, Shih-Pai 
Rd., Sec. 2, Peitou, Taipei, Taiwan. Email: jauching@gmail.com
AiP/IP ENTRY DATE
  2016-05-10
FULL RECORD ENTRY DATE
  2016-05-25
SOURCE
  Journal of Neurosurgery: Spine (2014) 21:6 (929-937). Date of Publication: 1 
Dec 2014
VOLUME
  21
ISSUE
  6
FIRST PAGE
  929
LAST PAGE
  937
DATE OF PUBLICATION
  1 Dec 2014
ISSN
  1547-5646 (electronic)
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons, jnevro@virginia.edu
ABSTRACT
  Object: The goal of the study was to report a series of consecutive patients 
who underwent endoscopic transnasal odontoidectomy (ETO) without resection 
of nasal turbinates. The techniques for this minimally invasive approach are 
described in detail. Methods: The authors conducted a retrospective review 
of consecutive patients who underwent ETO for basilar invagination. All the 
patients had myelopathy caused by compression at the cervicomedullary 
junction, which required surgical decompression. Preoperative and 
postoperative data, including those from radiographic and clinical 
evaluations, were compared. Morbidity and mortality rates for the procedure 
are also reported in detail. Results: Thirteen patients (6 men and 7 women) 
with a mean age of 52.7 years (range 24-72 years) were enrolled. The basilar 
invagination etiologies were rheumatoid arthritis (n = 5), trauma (n = 4), 
os odontoideum (n = 2), ankylosing spondylitis (n = 1), and postinfectious 
deformity (n = 1). The average follow-up duration was 51.2 months (range 
0.3-105 months). One patient died 10 days after the operation as a result of 
meningitis caused by CSF leakage. Among the other 12 patients, the average 
postoperative Nurick grade (3.2) was significantly improved over that before 
the operation (4.1, p = 0.004). The mean (± SD) duration of postoperative 
intubation was 1.5 ± 2.1 days, and there was no need for perioperative 
tracheostomy or nasogastric tube feeding. There also was no postoperative 
velopharyngeal insufficiency. There were 6 (46%) intraoperative and 2 (15%) 
postoperative CSF leaks in the 13 patients in this series. Conclusions: ETO 
is a viable and effective option for decompression at the ventral 
cervicomedullary junction. This approach is minimally invasive and causes 
little velopharyngeal insufficiency. The pitfall of this approach is the 
difficulty in repairing dural defects and subsequent CSF leakage.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endoscopic surgery; endoscopic transnasal odontoidectomy; minimally invasive surgery; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; ankylosing spondylitis (surgery); article; bone malformation; cerebrospinal fluid rhinorrhea (complication, surgery); clinical article; clinical evaluation; controlled study; drainage catheter; female; follow up; human; male; medical record review; meningitis (complication); middle aged; morbidity; multiple organ failure (complication); nasogastric tube; nose feeding; Nurick (grade); odontoid process; odontoid process fracture (surgery); outcome assessment; palatopharyngeal incompetence; peroperative complication (complication); postoperative complication (complication); postoperative period; preoperative evaluation; respiratory tract intubation; retrospective study; rheumatoid arthritis; sepsis (complication); spinal cord decompression; spinal cord disease (complication); Streptococcus pneumonia; surgical mortality; tracheostomy; treatment outcome; vertebra dislocation (surgery); 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160345140
MEDLINE PMID
  25279654 (http://www.ncbi.nlm.nih.gov/pubmed/25279654)
PUI
  L610212107
DOI
  10.3171/2014.8.SPINE13504
FULL TEXT LINK
  http://dx.doi.org/10.3171/2014.8.SPINE13504
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475646&id=doi:10.3171%2F2014.8.SPINE13504&atitle=Endoscopic+transnasal+odontoidectomy+without+resection+of+nasal+turbinates%3A+Clinical+outcomes+of+13+patients&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=21&issue=6&spage=929&epage=937&aulast=Yen&aufirst=Yu-Shu&auinit=Y.-S.&aufull=Yen+Y.-S.&coden=&isbn=&pages=929-937&date=2014&auinit1=Y&auinitm=-S
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 388
TITLE
  Five-level cervical corpectomy for neurofibromatosis-associated spinal 
deformity: case report
AUTHOR NAMES
  Parker S.L.; Wolinsky J.P.; Tufaro A.P.; Gokaslan Z.L.; Witham T.F.
AUTHOR ADDRESSES
  (Parker S.L., slparker7@gmail.com) Department of Neurosurgery, Vanderbilt 
University Medical Center, Nashville, United States.
(Wolinsky J.P.; Gokaslan Z.L.; Witham T.F., twitham2@jhmi.edu) Department of 
Neurosurgery, The Johns Hopkins Hospital, 600 N. Wolfe Street, Meyer 7-109, 
Baltimore, United States.
(Tufaro A.P.) Department of Surgery, The Johns Hopkins Hospital, Baltimore, 
United States.
CORRESPONDENCE ADDRESS
  S.L. Parker, Department of Neurosurgery, Vanderbilt University Medical 
Center, Nashville, United States.
AiP/IP ENTRY DATE
  2014-12-01
SOURCE
  European Spine Journal (2014) . Date of Publication: 22 Nov 2014
DATE OF PUBLICATION
  22 Nov 2014
ISSN
  1432-0932 (electronic)
  0940-6719
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Purpose: To describe a successful five-level cervical corpectomy and 
circumferential reconstruction in a patient with a plexiform neurofibroma 
causing a severe kyphotic deformity.Methods: Case report.Results: 
43-year-old man with history of Neurofibromatosis presented with signs and 
symptoms of myelopathy with spastic lower extremities and gait difficulties. 
Imaging studies demonstrated a severe kyphotic deformity of the cervical 
spine with associated cord compression secondary to an anteriorly positioned 
plexiform neurofibroma. Two-stage surgical procedure was designed to treat 
this lesion. Stage I consisted of tracheostomy placement, transmandibular, 
circumglossal approach to the anterior cervical spine, C2–C6 corpectomies, 
and C1–C7 reconstruction with a custom titanium cage/plate. Stage II 
consisted of suboccipital craniectomy, C1–C2 laminectomies, and 
occipital-cervical thoracic instrumented fusion (O-T8). There were no 
operative complications, but the patient did develop a small pulmonary 
embolism post-operatively treated with anticoagulation. Patient required 
two-weeks of inpatient rehabilitation following surgery. Gastrostomy tube 
and tracheostomy were successfully discontinued with preserved swallowing 
and respiratory function. Patient-reported outcome measurements revealed 
significant and sustained improvement post-operatively.Conclusions: 
Five-level cervical corpectomy including C2 can be safely and successfully 
performed via a transmandibular, circumglossal approach. Circumferential 
reconstruction utilizing a custom anterior titanium cage and plate system 
manufactured from a pre-operative CT scan was utilized in this case. Long 
segment occipital-cervical-thoracic reconstruction is recommended in such a 
case. Using such a technique, improvement in myelopathy, correction of 
deformity, and improved quality of life can be achieved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; deformity; human; neurofibromatosis; spine malformation; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014920566
MEDLINE PMID
  25416169 (http://www.ncbi.nlm.nih.gov/pubmed/25416169)
PUI
  L600545480
DOI
  10.1007/s00586-014-3682-3
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-014-3682-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-014-3682-3&atitle=Five-level+cervical+corpectomy+for+neurofibromatosis-associated+spinal+deformity%3A+case+report&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=&issue=&spage=&epage=&aulast=Parker&aufirst=Scott+L.&auinit=S.L.&aufull=Parker+S.L.&coden=ESJOE&isbn=&pages=-&date=2014&auinit1=S&auinitm=L
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 389
TITLE
  Decanulation of patients with severe respiratory muscle insufficiency: 
efficacy of mechanical insufflation-exsufflation
AUTHOR NAMES
  Bach J.R.; Saporito L.R.; Shah H.R.; Sinquee D.
AUTHOR ADDRESSES
  (Bach J.R.; Saporito L.R.; Shah H.R.; Sinquee D.) Department of Physical 
Medicine and Rehabilitation, University Hospital B-403, UMDNJ-New Jersey 
Medical School, 150 Bergen St, Newark, NJ 07103, USA. 
bachjr@njms.rutgers.edu
FULL RECORD ENTRY DATE
  2015-02-11
SOURCE
  Journal of rehabilitation medicine (2014) 46:10 (1037-1041). Date of 
Publication: 4 Nov 2014
VOLUME
  46
ISSUE
  10
FIRST PAGE
  1037
LAST PAGE
  1041
DATE OF PUBLICATION
  4 Nov 2014
ISSN
  1651-2081 (electronic)
ABSTRACT
  OBJECTIVE: Ventilator dependent patients with neuromuscular disorders and 
high level spinal cord injury have been extubated and decanulated to 
continuous noninvasive intermittent positive pressure ventilatory support 
after mechanical insufflation-exsufflation was used to achieve specific 
criteria for tube removal. The purpose of this study is to report changes in 
extent of need for ventilator use and in vital capacity related to 
mechanical insufflation-exsufflation used via tracheostomy tubes and 
post-decanulation via oronasal interfaces.METHODS: Upon presentation 
patients were placed on fiO2 21% and CO2 was normalized by adjusting 
ventilator settings as needed. The vital capacity (1st data point) and h/day 
of ventilator dependence were noted. Then mechanical 
insufflation-exsufflation was used via the tubes up to every 2 h until 
ambient air oxyhemoglobin saturation (SpO2) baseline remained ≥ 95% and 
other decanulation criteria were achieved. The vital capacity was 
re-measured (2nd data point) and the patient decanulated to continuous 
noninvasive intermittent positive pressure ventilatory support in ambient 
air as care providers used mechanical insufflation-exsufflation up to every 
30 min to maintain SpO2 ≥ 95%. The vital capacity (3rd data point) and 
minimum hours/day of noninvasive intermittent positive pressure ventilatory 
support requirement during the next 3 weeks were recorded.RESULTS: The vital 
capacities of 61 tracheostomized ventilator users, 36 of whom were 
continuously dependent, increased significantly (p < 0.001) from 
presentation to immediately pre-decanulation and in the 3 weeks 
post-decanulation and all except one were successfully 
decanulated.CONCLUSION: Many ventilator users can be decanulated in 
outpatient clinics to continuous noninvasive intermittent positive pressure 
ventilatory support with mechanical insufflation-exsufflation used to 
increase vital capacity, SpO2, and autonomous ability to breathe.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intermittent positive pressure ventilation; pathophysiology; procedures; 
EMTREE MEDICAL INDEX TERMS
  adult; aeration; artificial ventilation; artificial ventilation; breathing muscle; devices; female; human; male; middle aged; neuromuscular disease; respiratory failure; spinal cord injury; tracheostomy; vital capacity; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  25096928 (http://www.ncbi.nlm.nih.gov/pubmed/25096928)
PUI
  L602067900
DOI
  10.2340/16501977-1874
FULL TEXT LINK
  http://dx.doi.org/10.2340/16501977-1874
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16512081&id=doi:10.2340%2F16501977-1874&atitle=Decanulation+of+patients+with+severe+respiratory+muscle+insufficiency%3A+efficacy+of+mechanical+insufflation-exsufflation&stitle=J+Rehabil+Med&title=Journal+of+rehabilitation+medicine&volume=46&issue=10&spage=1037&epage=1041&aulast=Bach&aufirst=John+R.obert&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=1037-1041&date=2014&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2015 Medline is the source for the citation and abstract of this 
record.

RECORD 390
TITLE
  Respiratory-aided, long-term survival cases of amyotrophic lateral sclerosis 
(ALS) with communication abilities, motoneuron system-confined degeneration, 
and scanty TDP-43 aggregation-a subgroup of ALS?
AUTHOR NAMES
  Mochizuki Y.; Hayashi K.; Nakayama Y.; Shimizu T.; Kamide M.; Ogino M.; Komori T.; Isozaki E.; Nakano I.
AUTHOR ADDRESSES
  (Mochizuki Y., mochi@nihon-u.ne.jp; Hayashi K.; Shimizu T.; Komori T.; 
Isozaki E.; Nakano I.) Tokyo Metropolitan Neurological Hospital, Tokyo, 
Japan.
(Mochizuki Y., mochi@nihon-u.ne.jp) Tokyo Metropolitan Kita Medical and 
Rehabilitation Center for the Disabled, Tokyo, Japan.
(Nakayama Y.) Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
(Kamide M.) Atsugi City Hospital, Kanaagaa, Japan.
(Ogino M.) Kitasato University, School of Medicine, Kanagwa, Japan.
CORRESPONDENCE ADDRESS
  Y. Mochizuki, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. Email: 
mochi@nihon-u.ne.jp
FULL RECORD ENTRY DATE
  2014-12-01
SOURCE
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2014) 15 
SUPPL. 1 (160). Date of Publication: November 2014
VOLUME
  15
FIRST PAGE
  160
DATE OF PUBLICATION
  November 2014
CONFERENCE NAME
  25th International Symposium on ALS/MND
CONFERENCE LOCATION
  Brussels, Belgium
CONFERENCE DATE
  2014-12-05 to 2014-12-07
ISSN
  2167-8421
BOOK PUBLISHER
  Informa Healthcare
ABSTRACT
  Background: About 13% of patients (1) with ALS surviving on long-term 
mechanical ventilation (LTMV) develop into a totally locked-in state (TLS) 
(2), which refers to a state in which all voluntary movements are lost and 
communication by any means is impossible. However, it is known that some 
respirator-aided, long-term survival patients maintain communication 
abilities. The position that the latter group occupies along the spectrum of 
ALS cases has not been described. Objective: To clarify, along the ALS 
cases, the position of the long-surviving ALS subgroup with good 
communication abilities. Methods: Three autopsied ALS cases with an 
approximately 30-year survival and good communication abilities were 
clinicopathologically investigated in direct comparison with previously 
reported ALS cases suffering from a TLS (2, 3). Case reports: Clinical 
course: Age of onset and disease duration of cases 1, 2, and 3 were 48, 55, 
and 31, and 28, 29, and 33 years, respectively. Case 1 underwent a 
tracheostomy 8 years after disease onset, and required mechanical 
ventilation regularly 26 years after onset. Case 2 and case 3 underwent 
mechanical ventilation 14 and 6 years after disease onset, respectively. 
Case 1 and 3 were in a state of complete tetraplegia and case 2 was able to 
move only his knee joint a little, and the three cases were in a state of 
bulbar palsy. However they could communicate well via eye movements. 
Neuropathological findings: In all the cases, both upper and lower motor 
neurons were markedly degenerated while the brainstem tegmentum was 
preserved. Multiple system degeneration, a characteristic pathology of ALS 
in the TLS (2), was not seen. A few normal-looking motor neurons remained in 
the anterior horn of the spinal cord. Neither hypertrophic astrocytes nor 
macrophages were observed. There were no TDP-43-immunoreactive inclusions in 
the lower motor neurons of any case and only occasional ones in the cerebral 
cortex of case 3. Bunina bodies were not seen. Discussion and conclusion: 
Each of the present cases displayed a much slower disease progression into 
required respiratory assistance compared with typical ALS patients and also 
maintained good communication in spite of survival on LTMV. 
Neuropathological findings of remaining good-shaped motor neurons, 
motoneuron system-confined degeneration, and a few TDP-43-immunoreactive 
inclusions indicate a significant difference from findings of ALS in the 
TLS. Thus, our clinicopathological investigations of these three cases give 
rise to the possibility that there is a distinct subgroup characterized by 
the above-mentioned features.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis; artificial ventilation; degeneration; interpersonal communication; long term survival; motoneuron; 
EMTREE MEDICAL INDEX TERMS
  astrocyte; brain cortex; brain stem; bulbar paralysis; case report; disease course; disease duration; eye movement; human; knee; macrophage; onset age; pathology; patient; quadriplegia; spinal cord; spinal cord ventral horn; survival; tegmentum; tracheostomy; ventilator; voluntary movement; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71691132
DOI
  10.3109/21678421.2014.960185/196
FULL TEXT LINK
  http://dx.doi.org/10.3109/21678421.2014.960185/196
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21678421&id=doi:10.3109%2F21678421.2014.960185%2F196&atitle=Respiratory-aided%2C+long-term+survival+cases+of+amyotrophic+lateral+sclerosis+%28ALS%29+with+communication+abilities%2C+motoneuron+system-confined+degeneration%2C+and+scanty+TDP-43+aggregation-a+subgroup+of+ALS%3F&stitle=Amyotrophic+Lateral+Scler.+Frontotemporal+Degener.&title=Amyotrophic+Lateral+Sclerosis+and+Frontotemporal+Degeneration&volume=15&issue=&spage=160&epage=&aulast=Mochizuki&aufirst=Y.&auinit=Y.&aufull=Mochizuki+Y.&coden=&isbn=&pages=160-&date=2014&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 391
TITLE
  Surgical strategies and outcomes of spinal ependymomas of different lengths: 
Analysis of 210 patients
AUTHOR NAMES
  Wang G.
AUTHOR ADDRESSES
  (Wang G.) Beijing Tiantan Hospital, Beijing, China.
CORRESPONDENCE ADDRESS
  G. Wang, Beijing Tiantan Hospital, Beijing, China.
FULL RECORD ENTRY DATE
  2015-02-03
SOURCE
  Neuro-Oncology (2014) 16 SUPPL. 5 (v210). Date of Publication: November 2014
VOLUME
  16
FIRST PAGE
  v210
DATE OF PUBLICATION
  November 2014
CONFERENCE NAME
  19th Annual Scientific Meeting of the Society for Neuro-Oncology
CONFERENCE LOCATION
  Miami, FL, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1522-8517
BOOK PUBLISHER
  Oxford University Press
ABSTRACT
  OBJECTIVE: The aim of this study was to investigate the surgical strategies 
and outcomes for spinal ependymomas of different lengths. METHODS: The 
authors used data from 210 patients with spinal ependymomas (WHO Grades II 
and III) in this 10-year retrospective study (January 1999 to December 
2008), dividing them into 3 different groups according to length (spinal 
ependymomas < 5 cm, 5-10 cm, and > 10 cm). All patients underwent tumor 
resection. The basic characteristics of the patients were reviewed and the 
functional status was assessed using the McCormick classification. RESULTS: 
There were 89, 81, and 40 patients, respectively, in the 3 groups (< 5 cm, 
5-10 cm, and > 10 cm). Grosstotal resections (GTRs) were performed in 172 
patients (81.9% overall, or S6.5%, 79.0%, and 77.5% in the 3 groups, 
respectively). Subtotal and partial resections were achieved in 38 patients 
(18.1%). Eight patients with medulla oblongata or upper cervical cord tumors 
received a tracheotomy postoperatively. The follow-up period ranged from 56 
to 176 months. One hundred thirty-five patients (76.7%) experienced 
improvement, (88.2%, 83.8%, and 34.4% in the < 5 cm, 5-10 cm, and > 10 cm 
groups, respectively). Thirty-three patients (18.8%) maintained their 
pretreatment status, and 8 patients (4.5%) showed deterioration following 
tumor resection at 6 months. CONCLUSIONS: Radical resection of spinal 
ependymomas could be performed in most patients, and the rate of GTR was 
significantly different in the different-length groups Patients with longer 
tumors had worse surgical results compared with those with small tumors and 
more postoperative neuropathic pain and proprioceptive deficits could 
usually be observed in patients harboring larger tumors. Early diagnosis and 
timely operation are critical to achieving better neurological outcomes. For 
tumors with dense adhesions, complete removal should be performed cautiously 
because of the significant incidence of neurological deterioration.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  human; oncology; patient; society; 
EMTREE MEDICAL INDEX TERMS
  adhesion; cancer surgery; cervical spinal cord; classification; deterioration; early diagnosis; follow up; functional status; medulla oblongata; neoplasm; neuropathic pain; radical resection; retrospective study; surgery; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71763349
DOI
  10.1093/neuonc/nou274.5
FULL TEXT LINK
  http://dx.doi.org/10.1093/neuonc/nou274.5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15228517&id=doi:10.1093%2Fneuonc%2Fnou274.5&atitle=Surgical+strategies+and+outcomes+of+spinal+ependymomas+of+different+lengths%3A+Analysis+of+210+patients&stitle=Neuro-Oncology&title=Neuro-Oncology&volume=16&issue=&spage=v210&epage=&aulast=Wang&aufirst=Guihuai&auinit=G.&aufull=Wang+G.&coden=&isbn=&pages=v210-&date=2014&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 392
TITLE
  Institutional care for long-term mechanical ventilation in Canada: A 
national survey
AUTHOR NAMES
  Rose L.; McKim D.; Katz S.; Leasa D.; Nonoyama M.; Pedersen C.; Avendano M.; Goldstein R.
AUTHOR ADDRESSES
  (Rose L., louise.rose@utoronto.ca) Lawrence S Bloomberg Faculty of Nursing, 
University of Toronto, J55 College Street, Toronto, Canada.
(Rose L., louise.rose@utoronto.ca) Provincial Centre of Weaning 
Excellence/Prolonged Ventilation Weariing Centre, Toronto East General 
Hospital, Canada.
(Rose L., louise.rose@utoronto.ca) Sunnybrook Health Sciences Centre, 
Canada.
(Rose L., louise.rose@utoronto.ca) Li Ka Shing Knowledge Institute, St 
Michael's Hospital, Canada.
(Rose L., louise.rose@utoronto.ca; Avendano M.; Goldstein R.) West Park 
Healthcare Centre, Toronto, Canada.
(McKim D.) Ottawa Hospital Respiratory Rehabilitation and Ottawa Hospital 
Sleep Centre, Canada.
(McKim D.; Katz S.) University of Ottawa, Canada.
(Katz S.) Children's Hospital of Eastern Ontario, Canada.
(Katz S.) Eastern Ontario Research Institute, Children's Hospital, Ottawa, 
Canada.
(Leasa D.) London Health Sciences Centre, United Kingdom.
(Leasa D.) University of Western Ontario, London, United Kingdom.
(Nonoyama M.) Institute of Technology, University of Ontario, Oshawa, 
Canada.
(Pedersen C.; Goldstein R.) Centre for Research in Inner City Health, Li Ka 
Shing Institute, St Michael's Hospital, Canada.
(Avendano M.) University of Toronto, Toronto, Canada.
CORRESPONDENCE ADDRESS
  L. Rose, Lawrence S Bloomberg Faculty of Nursing, University of Toronto, J55 
College Street, Toronto, Canada.
AiP/IP ENTRY DATE
  2014-12-15
FULL RECORD ENTRY DATE
  2014-12-18
SOURCE
  Canadian Respiratory Journal (2014) 21:6 (357-362). Date of Publication: 1 
Nov 2014
VOLUME
  21
ISSUE
  6
FIRST PAGE
  357
LAST PAGE
  362
DATE OF PUBLICATION
  1 Nov 2014
ISSN
  1916-7245 (electronic)
  1198-2241
BOOK PUBLISHER
  Pulsus Group Inc., 410 Park Avenue, 15th Floor, 287 pmb, New York, United 
States.
ABSTRACT
  INTRODUCTION: No national Canadian data define resource require mcnts and 
care delivery for ventilator-assisted individuals (VAIs) requiring long-term 
institutional care. Such data will assist in planning health care services 
to this population.OBJECTIVE: To describe institutional and patient 
characteristics, prevalence, equipment used, care elements and admission 
barriers for VAIs requiring long-term institutional care.METHODS: Centres 
were identified from a national inventory and snow-ball referrals. The 
survey weblink was provided from December 2012 to April 2013. Weekly 
reminders were sent for six weeks.RESULTS: The response rate was 84% (54 of 
64), with 44 adult and 10 pediatric centres providing data for 428 VAIs (301 
invasive ventilation; 127 noninvasive ventilation [NIV]), equivalent to 1.3 
VAIs per 100,000 population. An additional 106 VAIs were on wait lists in 18 
centres. More VAIs with progressive neuromuscular disease received invasive 
ventilation than NIV (P<0.001); more VAIs with chronic obstructive pulmonary 
disease (P<0.001), obesity hypoventilation syndrome (P<0.001) and central 
hypoventilation syndrome (P=0.02) required NIV. All centres used positive 
pressure ventilators, 21% diaphragmatic pacing, 15% negative pressure and 
13% phrenic nerve stimulation. Most centres used lung volume recruitment 
(55%), manually (71%) and mechanically assisted cough (55%). Lack of beds 
and provincial funding were common admission barriers.CONCLUSIONS: Variable 
models and care practices exist for institutionalized care of Canadian VAIs. 
Patient prevalence was 1.3 per 100,000 Canadians. © 2014 Pulsus Group Inc. 
All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; institutional care; long term care; 
EMTREE MEDICAL INDEX TERMS
  adult; adult respiratory distress syndrome; aged; airway obstruction; Arnold Chiari malformation; article; Canada; cerebral palsy; cerebrovascular accident; chronic obstructive lung disease (therapy); congestive heart failure; coughing; Guillain Barre syndrome; health care survey; human; hydrocephalus; hypoventilation (therapy); injury; invasive procedure; lung volume; major clinical study; mechanical ventilator (adverse device effect); metabolic disorder; myasthenia gravis; negative pressure ventilator; nerve stimulation; neuromuscular disease (therapy); noninvasive ventilation; obesity hypoventilation syndrome (therapy); pediatric hospital; phrenic nerve; postpoliomyelitis syndrome; seizure; spinal cord injury; spinal dysraphism; trachea stenosis; tracheostomy; ventilator; ventilator associated pneumonia (complication, prevention); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  2014953284
PUI
  L600699836
DOI
  10.1155/2014/538687
FULL TEXT LINK
  http://dx.doi.org/10.1155/2014/538687
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19167245&id=doi:10.1155%2F2014%2F538687&atitle=Institutional+care+for+long-term+mechanical+ventilation+in+Canada%3A+A+national+survey&stitle=Can.+Respir.+J.&title=Canadian+Respiratory+Journal&volume=21&issue=6&spage=357&epage=362&aulast=Rose&aufirst=Louise&auinit=L.&aufull=Rose+L.&coden=CRJOF&isbn=&pages=357-362&date=2014&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 393
TITLE
  Non invasive assessment of the effect of implantable phrenic nerve 
stimulation in two paediatric patients using structured light 
plethysmography
AUTHOR NAMES
  Morley S.; Khalid A.; Kimber K.; De Boer W.; Iles R.
AUTHOR ADDRESSES
  (Morley S.; Kimber K.; Iles R., richard.iles@doctors.org.uk) Cambridge 
University Hospitals, NHS Foundation Trust, Cambridge, United Kingdom.
(Khalid A.; De Boer W.) PneumaCare Ltd, Cambridge, United Kingdom.
CORRESPONDENCE ADDRESS
  R. Iles, Cambridge University Hospitals, NHS Foundation Trust, Cambridge, 
United Kingdom. Email: richard.iles@doctors.org.uk
FULL RECORD ENTRY DATE
  2015-11-05
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2014) 189 
MeetingAbstracts. Date of Publication: 2014
VOLUME
  189
DATE OF PUBLICATION
  2014
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2014
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-05-16 to 2014-05-21
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Patient A is a 17 year old girl who sustained a C1 complete 
spinal cord injury at the age of 9 years. Patient B is a 10 year old boy who 
sustained a complete C1 spinal injury at the age of 6 years. Both children 
show no respiratory drive and have been invasively ventilated via 
tracheostomy since the time of injury. Neither has any other significant 
pathology. Following assessment both patients underwent insertion of 
bilateral Atrostim Implantable Phrenic Nerve Stimulators (IPNS) in 2013. 
Methodology: The children were studied using Structured Light 
Plethysmography (SLP) (Thora3Di TM PneumaCare Ltd, UK). SLP enables 
non-invasive, non-contact assessment of the compartmental change of Rib Cage 
(RC) v Abdominal (AB) and Right (RH) v left (LH) hemi-thorax. The movement 
of a projected grid of light is analysed to derive a Konno-Mead loop (KM) 
from which KM Principal Angle (Phi), KM Spread, Overall phase (OPhi), 
Windowed phase (W phase), Phase breath (B phase) and a measure of variation 
of per-breath phase (B phase Ent) can be calculated. Each child was 
monitored in a sitting and supine position both on invasive ventilation and 
on IPNS. Patient B was reassessed at 75% and 100% IPNS. Results: RC v AB: In 
both patients, in both positions, Phi became more negative with IPNS, 
indicating a shift from RC to an AC / diaphragmatic volume recruitment. 
There was an increase in KM spread in the supine position, but either no 
change or a negative change in the sitting position. KM Spread and Phase 
measurements became positive indicating a more complex multi phased mode of 
volume recruitment. Measurements changed when Patient B was paced at 75% and 
100% IPNS; Phi becoming more negative and the KM spread, decreased. B Phase 
Ent decreased in both positions indicating more respiratory stability. RH v 
LH: Patient A showed an increase in right sided ventilation in the sitting 
position following IPNS. There was a change in Phi between sitting and lying 
positions for both patients, however these changes were not the same for 
each patient. There was no difference in KM spread before or after IPNS in 
either patient. Conclusion: IPNS offers significant quality of life 
improvements for the patient, but effectiveness is often subjective. SLP 
offers a non-invasive method to objectively quantify and record the 
regional, idiosyncratic and positional effectiveness of IPNS, when compared 
to conventional ventilation and varying % IPNS support.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; human; nerve stimulation; patient; phrenic nerve; plethysmography; society; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; boy; breathing; child; female; girl; injury; male; methodology; nerve stimulator; non invasive procedure; pathology; quality of life; respiratory drive; sitting; spinal cord injury; spine injury; supine position; thorax; tracheostomy; United Kingdom; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L72048432
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Non+invasive+assessment+of+the+effect+of+implantable+phrenic+nerve+stimulation+in+two+paediatric+patients+using+structured+light+plethysmography&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=189&issue=&spage=&epage=&aulast=Morley&aufirst=S.&auinit=S.&aufull=Morley+S.&coden=&isbn=&pages=-&date=2014&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 394
TITLE
  Stentgraft first staged repair of type 2 thoraco-abdominal aneurysm: The 
endovascular elephant trunk
AUTHOR NAMES
  Vivacqua A.; Idrees J.; Johnston D.R.; Soltesz E.; Svensson L.; Roselli E.
AUTHOR ADDRESSES
  (Vivacqua A.; Idrees J.; Johnston D.R.; Soltesz E.; Svensson L.; Roselli E.) 
Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, 
United States.
CORRESPONDENCE ADDRESS
  A. Vivacqua, Thoracic and Cardiovascular Surgery, Cleveland Clinic 
Foundation, Cleveland, United States.
FULL RECORD ENTRY DATE
  2014-12-01
SOURCE
  Interactive Cardiovascular and Thoracic Surgery (2014) 19 SUPPL. 1 (S2). 
Date of Publication: October 2014
VOLUME
  19
FIRST PAGE
  S2
DATE OF PUBLICATION
  October 2014
CONFERENCE NAME
  28th Annual Meeting of the European Association for Cardio-Thoracic Surgery, 
EACTS 2014
CONFERENCE LOCATION
  Milan, Italy
CONFERENCE DATE
  2014-10-11 to 2014-10-15
ISSN
  1569-9293
BOOK PUBLISHER
  Oxford University Press
ABSTRACT
  Abstract Objectives: Repair of extensive thoraco-abdominal aneurysm carries 
high risk of death and morbidity, especially spinal cord ischaemia. 
Objectives were to investigate outcomes with a staged hybrid approach using 
a thoracic endovascular aortic repair (TEVAR) first in combination with 
later open abdominal repair for type 2 thoraco-abdominal aneurysm. Methods: 
From to 2001 to 2013, 22 patients underwent TEVAR first staged type 2 
thoraco-abdominal repair for degenerative aneurysm and dissection. The first 
stage included descending aortic endovascular repair (endovascular elephant 
trunk), followed by completion repair with open replacement of the visceral 
and abdominal segment. At initial repair, all patients were deemed high risk 
for conventional open repair. Median interval between stages was 6.5 months. 
Mean age was 56 ± 15 years, 5 patients had connective tissue disorder and 
the mean maximum aortic diameter was 58 ± 16°mm preoperatively. Results: 
There was no death or major complication after initial TEVAR, but the 
operative mortality was 9% (n = 2) after open procedure. One patient 
underwent emergency repair and died due to intraoperative myocardial 
infarction and the other had disseminated intravascular coagulation. Other 
complications included paralysis (n = 1, 4.5%), tracheostomy (n = 2, 9%), 
dialysis (n = 1, 4.5%), and there was 1 reoperation for bleeding (4.5%). 
Median follow-up was 37 months and there were no late deaths, but 1 late 
reoperation for a new ascending dissection. Conclusion: Use of TEVAR as 
endovascular elephant trunk in combination with staged open repair is a safe 
and feasible approach for repair of extensive type 2 thoraco-abdominal 
aneurysm. Staged approach with TEVAR first may reduce morbidity in patients 
at high risk for extensive single stage aortic repair.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm; elephant; thorax surgery; 
EMTREE MEDICAL INDEX TERMS
  aorta; aortic reconstruction; bleeding; connective tissue disease; death; dialysis; dissection; disseminated intravascular clotting; emergency; endovascular aneurysm repair; follow up; heart infarction; human; ischemia; morbidity; paralysis; patient; procedures; reoperation; risk; spinal cord; surgical mortality; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71689204
DOI
  10.1093/icvts/ivu276.5
FULL TEXT LINK
  http://dx.doi.org/10.1093/icvts/ivu276.5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15699293&id=doi:10.1093%2Ficvts%2Fivu276.5&atitle=Stentgraft+first+staged+repair+of+type+2+thoraco-abdominal+aneurysm%3A+The+endovascular+elephant+trunk&stitle=Interact.+Cardiovasc.+Thorac.+Surg.&title=Interactive+Cardiovascular+and+Thoracic+Surgery&volume=19&issue=&spage=S2&epage=&aulast=Vivacqua&aufirst=A.&auinit=A.&aufull=Vivacqua+A.&coden=&isbn=&pages=S2-&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 395
TITLE
  Intrathecal baclofen withdrawal: A rare cause of high morbidity and 
mortality
AUTHOR NAMES
  Logue L.; Saini P.; Babinski K.; Russi T.
AUTHOR ADDRESSES
  (Logue L.; Saini P.; Babinski K.; Russi T.) New York Methodist Hospital, 
Brooklyn, United States.
CORRESPONDENCE ADDRESS
  L. Logue, New York Methodist Hospital, Brooklyn, United States.
FULL RECORD ENTRY DATE
  2015-02-13
SOURCE
  Chest (2014) 146:4 MEETING ABSTRACT. Date of Publication: October 2014
VOLUME
  146
ISSUE
  4
DATE OF PUBLICATION
  October 2014
CONFERENCE NAME
  CHEST 2014
CONFERENCE LOCATION
  Austin, TX, United States
CONFERENCE DATE
  2014-10-25 to 2014-10-30
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians
ABSTRACT
  INTRODUCTION: Baclofen withdrawal rarely occurs in patients receiving 
intrathecal baclofen (ITB). We report a patient with spasticity that quickly 
declined to circulatory shock requiring prolonged hospitalization. CASE 
PRESENTATION: 44 year-old man with T1 paraplegia and lower extremity 
spasticity, from prior gunshot needing an ITB pump, presented with episodic 
dyspnea, confusion, and lower extremity cramps for 2 days. He admitted to 
regular pump interrogations and refills. Exam revealed an anxious man with 
tachycardia, tachypnea, and hypertensive emergency. He had myoclonus, intact 
deep tendon reflexes, and absent voluntary motor function of his lower 
extremities. Labs showed leucocytosis, elevated creatinine kinase, and 
toxicology positive for cocaine. Oral baclofen and intravenous diazepam was 
futile. Rapid respiratory failure requiring intubation and mechanical 
ventilation, shock and hyperthermia (108°F) ensued. He was cooled, volume 
resuscitated, started on vasopressors, broad-spectrum antibiotics, 
benzodiazepines, and supra-therapeutic oral doses of baclofen. Injection of 
baclofen into the pump and trial of cyproheptadine were ineffective. Imaging 
and electroencephalography ruled out stroke and seizures. Renal failure 
requiring dialysis, limb ischemia requiring leg amputation, myocardial 
infarction, deep vein thrombosis and prolonged mechanical ventilation 
requiring tracheostomy complicated his hospitalization. Sedation was slowly 
withdrawn correlating with a decline in spasms. After 2 months, he followed 
simple commands and was discharged to rehabilitation. DISCUSSION: Spasticity 
occurs from alpha or gamma motor neuron inhibition after spinal injury. 
Baclofen is a gamma-aminobutyric acid type-B receptor agonist that binds 
presynaptically, decreasing calcium release resulting in decreased muscle 
tone1. ITB doses can be multi-fold higher than oral doses. ITB withdrawal 
from human or device error can be life-threatening. Patients may develop 
rigidity, seizures, hyperthermia, and shock. Multi-organ dysfunction, 
disseminated intravascular coagulation, and death can result. Intensivists 
must be cognizant of confounding etiologies such as cocaine use and 
neuroleptic malignant syndrome. Electroencephalogram aids in differentiating 
status dystonicus from status epilepticus. Treatment is baclofen replacement 
and supportive. In severe cases, early intubation, mechanical ventilation, 
benzodiazepines, anesthesia, and paralytics have reduced complications2. 
Patients refractory to replacement require slow down-titration of sedation 
and prolonged hospitalization. CONCLUSIONS: Severe cases are rare but need a 
heightened awareness in patients with myalgias and ITB pumps. Intensivists 
must have a low threshold for early intubation and intravenous sedation 
before the development of complications in such cases.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  baclofen; 
EMTREE DRUG INDEX TERMS
  4 aminobutyric acid; antibiotic agent; benzodiazepine derivative; cocaine; creatine kinase; cyproheptadine; diazepam; hypertensive factor; receptor; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intrathecal drug administration; morbidity; mortality; 
EMTREE MEDICAL INDEX TERMS
  agonist; anesthesia; artificial ventilation; calcium transport; cerebrovascular accident; death; deep vein thrombosis; devices; dialysis; disseminated intravascular clotting; dyspnea; electroencephalogram; electroencephalography; emergency; epileptic state; etiology; gamma motoneuron; gunshot injury; heart infarction; hospitalization; human; hyperthermia; imaging; injection; intensivist; intubation; kidney failure; leg; leg amputation; leukocytosis; limb ischemia; male; motor performance; muscle; muscle cramp; muscle spasm; myalgia; myoclonus; neuroleptic malignant syndrome; paraplegia; patient; pump; rehabilitation; respiratory failure; rigidity; sedation; seizure; shock; spasticity; spine injury; tachycardia; tachypnea; tendon reflex; titrimetry; toxicology; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71780430
DOI
  10.1378/chest.1969368
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.1969368
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.1969368&atitle=Intrathecal+baclofen+withdrawal%3A+A+rare+cause+of+high+morbidity+and+mortality&stitle=Chest&title=Chest&volume=146&issue=4&spage=&epage=&aulast=Logue&aufirst=Lelia&auinit=L.&aufull=Logue+L.&coden=&isbn=&pages=-&date=2014&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 396
TITLE
  Contemporary approach of thoraco-abdominal aortic repair using moderate to 
deep hypothermia combined with target reconstruction of the adamkiewicz 
artery
AUTHOR NAMES
  Tanaka H.; Minatoya K.; Sasaki H.; Oda T.; Itonaga T.; Kobayashi J.
AUTHOR ADDRESSES
  (Tanaka H.; Minatoya K.; Sasaki H.; Oda T.; Itonaga T.; Kobayashi J.) 
Department of Cardiovascular Surgery, National Cerebral and Cardiovascular 
Center, Osaka, Japan.
CORRESPONDENCE ADDRESS
  H. Tanaka, Department of Cardiovascular Surgery, National Cerebral and 
Cardiovascular Center, Osaka, Japan.
FULL RECORD ENTRY DATE
  2014-12-01
SOURCE
  Interactive Cardiovascular and Thoracic Surgery (2014) 19 SUPPL. 1 (S63). 
Date of Publication: October 2014
VOLUME
  19
FIRST PAGE
  S63
DATE OF PUBLICATION
  October 2014
CONFERENCE NAME
  28th Annual Meeting of the European Association for Cardio-Thoracic Surgery, 
EACTS 2014
CONFERENCE LOCATION
  Milan, Italy
CONFERENCE DATE
  2014-10-11 to 2014-10-15
ISSN
  1569-9293
BOOK PUBLISHER
  Oxford University Press
ABSTRACT
  Objectives: We reviewed the surgical results of thoraco-abdominal aortic 
repair using moderate to deep hypothermia combined with target 
reconstruction of the Adamkiewicz artery Methods: Between 2006 and 2014, 100 
patients underwent thoraco-abdominal aortic aneurysm repair using moderate 
to deep hypothermia. Mean age was 58 ± 15 years. Seventy-three (73%) were 
men. Aortic pathology was acute dissection in 5, chronic dissection in 74, 
degenerative in 20, and infection in 1. Thirty-four had connective tissue 
disorders. Five had emergent operation. The degree of repair was Crawford 
extent I in 8, II in 79, and III in 13. Four had concomitant arch repair. 
Preoperative magnetic resonance angiography or computed tomographic 
angiography was performed to detect the Adamkiewicz artery. We used deep 
hypothermia (18°C) requiring open proximal aortic anastomosis for cerebral 
protection, and moderate hypothermia (25°C) in patients not requiring 
cerebral protection Results: There were 2 patients with spinal cord injury 
and 2 with stroke. Of the patients with the identified Adamkiewicz artery 
(90%), all had target reconstruction of the artery. Mean number of pairs of 
reconstructed intercostal arteries was 1.5 ± 0.7. In-hospital mortality was 
5%. The cause of death was lung bleeding in 2, infection in 2, and rupture 
of iliac aneurysm in 1. Temporary dialysis for new-onset renal failure was 
required in 9%. Mean duration of postoperative mechanical ventilation was 
1.7 ± 1.9 days. Six had tracheostomy due to respiratory failure Conclusion: 
Moderate to deep hypothermia combined with target reconstruction of the 
Adamkiewicz artery brings satisfactory outcomes in thoraco-abdominal aortic 
repair, especially for spinal cord protection.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artery; descending aortic surgery; hypothermia; thorax surgery; 
EMTREE MEDICAL INDEX TERMS
  abdominal aortic aneurysm; anastomosis; aneurysm; artificial ventilation; cause of death; cerebrovascular accident; computed tomographic angiography; connective tissue disease; dialysis; dissection; human; infection; kidney failure; lung hemorrhage; magnetic resonance angiography; male; mortality; pathology; patient; protection; respiratory failure; rupture; spinal cord; spinal cord injury; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71689408
DOI
  10.1093/icvts/ivu276.210
FULL TEXT LINK
  http://dx.doi.org/10.1093/icvts/ivu276.210
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15699293&id=doi:10.1093%2Ficvts%2Fivu276.210&atitle=Contemporary+approach+of+thoraco-abdominal+aortic+repair+using+moderate+to+deep+hypothermia+combined+with+target+reconstruction+of+the+adamkiewicz+artery&stitle=Interact.+Cardiovasc.+Thorac.+Surg.&title=Interactive+Cardiovascular+and+Thoracic+Surgery&volume=19&issue=&spage=S63&epage=&aulast=Tanaka&aufirst=H.&auinit=H.&aufull=Tanaka+H.&coden=&isbn=&pages=S63-&date=2014&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 397
TITLE
  Open thoracoabdominal aortic repair for chronic type B dissection
AUTHOR NAMES
  Kouchoukos N.T.; Kulik A.; Castner C.F.
AUTHOR ADDRESSES
  (Kouchoukos N.T., ntkouch@aol.com; Castner C.F.) Division of Cardiovascular 
and Thoracic Surgery, Missouri Baptist Medical Center, St Louis, Mo
(Kulik A.) Division of Cardiothoracic Surgery, Lynn Heart Institute, Boca 
Raton Regional Hospital, Boca Raton, Fla
CORRESPONDENCE ADDRESS
  N.T. Kouchoukos, Division of Cardiovascular and Thoracic Surgery, Missouri 
Baptist Medical Center, St Louis, Mo, . Email: ntkouch@aol.com
AiP/IP ENTRY DATE
  2014-09-13
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2014)
ISSN
  0022-5223
  1097-685X (electronic)
ABSTRACT
  Objectives: Advances in endovascular surgery have brought into question the 
role of open operative treatment of chronic thoracoabdominal aortic 
dissection. In this context, we evaluated our experience with open repair of 
this condition using a single operative technique. Methods: From January 
1986 to January 2014, 69 patients with chronic thoracoabdominal aortic 
dissection underwent open repair using total cardiopulmonary bypass (CPB) 
and hypothermic circulatory arrest (HCA). The degree of repair was as 
follows: Crawford extent I, 13 patients (19%), Crawford extent II, 41 
patients (59%), and Crawford extent III, 15 patients (22%). Thirty patients 
(43%) had Marfan or Loeys-Dietz syndrome. Fifty-three patients (77%) had 
previous operations on the thoracic or abdominal aorta. Results: The 30-day 
mortality rate was 5.8% (4 patients). Stroke occurred in 2 (3%) of 66 
operative survivors, and spinal cord ischemic injury in 4 (6%). Temporary 
dialysis for new-onset renal failure was required in 4.5% of hospital 
survivors and tracheostomy in 10.6%. Survival after 1, 5, and 10 years was 
87%, 65%, and 40%, respectively. Eighteen patients (26%) required a total of 
20 subsequent operations on the thoracic or abdominal aorta of whom 15 had 
Marfan or Loeys-Dietz syndrome. Three of these procedures were for 
contiguous distal aortic disease and 10 were for patch aneurysms of the 
intercostal or visceral/renal arteries. Conclusions: Open thoracoabdominal 
aortic repair for chronic dissection using CPB and HCA can be accomplished 
with mortality and morbidity rates that are comparable with those reported 
for endovascular or hybrid techniques. Open repair should remain a viable 
and primary option for the management of this condition until the long-term 
effectiveness of alternative methods of treatment is clearly established. © 
2014 The American Association for Thoracic Surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic reconstruction; dissection; 
EMTREE MEDICAL INDEX TERMS
  abdominal aorta; aneurysm; aortic disease; aortic dissection; artery; cardiopulmonary bypass; cerebrovascular accident; dialysis; endovascular surgery; heart arrest; hospital; human; injury; kidney failure; Loeys Dietz syndrome; morbidity; mortality; patient; procedures; spinal cord; surgery; surgical technique; survival; survivor; thorax surgery; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L53324828
DOI
  10.1016/j.jtcvs.2014.07.064
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2014.07.064
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225223&id=doi:10.1016%2Fj.jtcvs.2014.07.064&atitle=Open+thoracoabdominal+aortic+repair+for+chronic+type+B+dissection&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=&issue=&spage=&epage=&aulast=Kouchoukos&aufirst=Nicholas+T.&auinit=N.T.&aufull=Kouchoukos+N.T.&coden=JTCSA&isbn=&pages=-&date=2014&auinit1=N&auinitm=T
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 398
TITLE
  Respiratory nursing interventions following tracheostomy in acute traumatic 
cervical spinal cord injury
AUTHOR NAMES
  Luo C.; Yang H.; Chen Y.; Zhang Z.; Gong Z.
AUTHOR ADDRESSES
  (Luo C.; Yang H.; Chen Y.; Zhang Z.; Gong Z.) Department of Orthopedics, 
Xinqiao Hospital, Third Military Medical University, 183 Xinqiao Street, 
Shapingba District, Chongqing, 400037, China
FULL RECORD ENTRY DATE
  2015-09-08
SOURCE
  Cell biochemistry and biophysics (2014) 70:1 (455-459). Date of Publication: 
1 Sep 2014
VOLUME
  70
ISSUE
  1
FIRST PAGE
  455
LAST PAGE
  459
DATE OF PUBLICATION
  1 Sep 2014
ISSN
  1559-0283 (electronic)
ABSTRACT
  Tracheostomy is frequently performed in severe cervical spinal cord injury 
(SCI) patients with the pulmonary dysfunction. A series of respiratory 
nursing interventions are required to plan tracheostomy removal. 
Tracheostomy was performed in 29 patients after acute traumatic cervical 
SCI. A series of respiratory nursing interventions were introduced in these 
patients after closed tracheostomy and decannulation, including closed 
tracheostomy tube training, manually assisted cough. Chacheostomy was 
successfully removed in 21 patients after the respiratory nursing 
interventions. In contrast, eight patients died from associated injuries. 
The average time from tracheostomy to decannulation was 40 days (14-104 
days), the average time from closed tracheostomy to decannulation was 18.80 
± 13.50 days. Second tracheostomy was performed in one patient after 29 
days' removal due to pulmonary infection. One patient presented with delayed 
incision healing for 29 days. Closed tracheostomy tube training and manually 
assisted cough are key factors for tracheostomy removal, although intensive 
nursing are also needed. The time from tracheostomy to decannulation and 
from closed tracheostomy to decannulation is increased in case of "late" 
(>24 h) tracheostomy and longer mechanical ventilation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injuries; respiratory system; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  acute disease; adolescent; adult; aged; cervical spinal cord; child; cohort analysis; female; human; male; middle aged; nursing; retrospective study; spinal cord injury (surgery); young adult; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  24728962 (http://www.ncbi.nlm.nih.gov/pubmed/24728962)
PUI
  L605883889
DOI
  10.1007/s12013-014-9940-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12013-014-9940-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15590283&id=doi:10.1007%2Fs12013-014-9940-5&atitle=Respiratory+nursing+interventions+following+tracheostomy+in+acute+traumatic+cervical+spinal+cord+injury&stitle=Cell+Biochem.+Biophys.&title=Cell+biochemistry+and+biophysics&volume=70&issue=1&spage=455&epage=459&aulast=Luo&aufirst=Chunmei&auinit=C.&aufull=Luo+C.&coden=&isbn=&pages=455-459&date=2014&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2015 Medline is the source for the citation and abstract of this 
record.

RECORD 399
TITLE
  Bickerstaff-s brainstem encephalitis variant of guillain-barre syndrome 
causing complete spinal cord injury: A case report
AUTHOR NAMES
  Solinsky R.; Smith C.H.
AUTHOR ADDRESSES
  (Smith C.H.)
(Solinsky R.) University of Washington, Seattle, United States.
CORRESPONDENCE ADDRESS
  R. Solinsky, University of Washington, Seattle, United States.
FULL RECORD ENTRY DATE
  2014-10-31
SOURCE
  PM and R (2014) 6:9 SUPPL. 1 (S338-S339). Date of Publication: September 
2014
VOLUME
  6
ISSUE
  9
FIRST PAGE
  S338
LAST PAGE
  S339
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  2014 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: A 46-year-old woman presented with 6 days of diarrhea, 
fever, altered mentation, and ataxia to an outside hospital. She quickly 
developed urinary retention, severe headache, diplopia, general tonic-clonic 
seizures, and flaccid paralysis requiring intubation. Extensive infectious 
workup was negative and she was treated with 5 days of intravenous 
immunoglobulin followed by 11 days of high dose steroids and an extended 
prednisone taper. Serum and CSF samples were sent to the Center for Disease 
Control who confirmed past Campylobacter jejuni infection and findings 
consistent with Bickerstaff-s brainstem encephalitis. She presented to acute 
inpatient rehabilitation 36 days after initial presentation with flaccid 
tetraplegia, dysphagia with PEG tube in place and on a ventilator with 
tracheostomy. Setting: Acute Inpatient Rehabilitation Unit Results or 
Clinical Course: Admission ASIA examination demonstrated C5 ASIA A 
tetraplegia with a zone of partial preservation (ZPP) bilaterally to 
sensory/motor level T4. She was weaned off the ventilator on day 6 and 
decannulated on day 15. Oropharyngeal dysphagia slowly resolved and tube 
feeds were discontinued on day 17. Patient developed a broad band of 
constrictive transitional zone pain extending from T6 to T12. Lower 
extremities remained largely flaccid, though discharge examination showed T6 
ASIA A tetraplegia with ZPP to L2 motor bilaterally. Total motor FIM score 
improved from 20 at admission to 66 at discharge and patient was able to 
return home, 95 days after initial presentation to outside hospital. 
Discussion: Bickerstaff brainstem encephalitis is a rare Guillain- Barre 
variant that lies on a continuous spectrum with Miller-Fisher syndrome and 
has typically been associated with opthalmoplegia, ataxia, altered 
mentation, hyperreflexia or areflexia and occasionally paralysis. Recovery 
time, FIM improvement, or mention of significant transitional zone pain has 
not been previously described to our knowledge. Conclusions: This case 
describes how acute inpatient rehabilitation can be effective in 
facilitating transition back to independence following tetraplegia from 
Bickerstaff-s brainstem encephalitis.
EMTREE DRUG INDEX TERMS
  immunoglobulin; prednisone; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain stem; case report; encephalitis; Guillain Barre syndrome; human; physical medicine; rehabilitation; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  areflexia; Campylobacter enteritis; cerebrospinal fluid; diarrhea; diplopia; disease control; disease course; drug megadose; dysphagia; examination; female; fever; flaccid paralysis; Functional Independence Measure; headache; hospital; hospital patient; hyperreflexia; independence; intubation; leg; pain; paralysis; patient; preservation; quadriplegia; serum; thinking; tonic clonic seizure; tracheostomy; tube; urine retention; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71643925
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Bickerstaff-s+brainstem+encephalitis+variant+of+guillain-barre+syndrome+causing+complete+spinal+cord+injury%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=6&issue=9&spage=S338&epage=S339&aulast=Smith&aufirst=Charlotte+H.&auinit=C.H.&aufull=Smith+C.H.&coden=&isbn=&pages=S338-S339&date=2014&auinit1=C&auinitm=H
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 400
TITLE
  Neuromuscular electrical stimulation is safe in children with intramuscular 
diaphragmatic pacers: A case series
AUTHOR NAMES
  MacDonald K.; Cagney J.; Martin R.; Sadowsky C.
AUTHOR ADDRESSES
  (Cagney J.; Martin R.; Sadowsky C.)
(MacDonald K.) Kennedy Krieger Institute, Baltimore, United States.
CORRESPONDENCE ADDRESS
  K. MacDonald, Kennedy Krieger Institute, Baltimore, United States.
FULL RECORD ENTRY DATE
  2014-10-31
SOURCE
  PM and R (2014) 6:9 SUPPL. 1 (S173). Date of Publication: September 2014
VOLUME
  6
ISSUE
  9
FIRST PAGE
  S173
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  2014 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Objective: Our objective is to present the first 3 known documented cases of 
successful use of Neuromuscular Electrical Stimulation (NMES) as an 
intervention with patients concurrently using Intramuscular Diaphragmatic 
Pacing Systems (IMDP) systems. Design: Retrospective Chart Review. Setting: 
Inpatient Pediatric Rehabilitation, Outpatient Rehabilitation. Participants: 
This case report discusses 3 patients with cervical level spinal cord 
injuries resulting in tetraplegia requiring respiratory support: male, age 
16 years C2 AIS A; female, age 10 years C2 AIS A; male, 4 years C2 AIS not 
confirmed secondary to age (presented as complete). All patients were 
implanted with IMDP for respiratory support; they utilized a tracheostomy 
and intermittently utilized positive pressure ventilation as a supplement to 
IMDP. Interventions: All 3 patients successfully participated in intensive 
Activity-Based Rehabilitation (ABR). Each patient received 4 to 6 hours a 
day of combined occupational and physical therapy. Interventions included, 
but were not limited to: Neuromuscular Electrical Stimulation (NMES) and 
neuro re-education, functional electrical stimulation assisted cycling, 
functional mobility, activities of daily living skills training, and range 
of motion and strengthening. NMES parameters were optimized for function and 
customized to patients' tolerance to achieve a muscle contraction. Patients 
were informed of the risks, benefits and alternatives for each intervention, 
including those involving NMES. Main Outcome Measures: Vital signs including 
pulse rate, respiratory rate, and oxygen saturation levels were monitored to 
track patient's responses during interventions. Results or Clinical Course: 
All sessions in which NMES was utilized resulted with no adverse response, 
no acute change, no clinical or subjective respiratory function changes, and 
no interference with the IMDP device. Therefore it is determined that NMES 
is safe to utilize in patients with an implanted IMDP. Conclusions: It is 
safe to utilize NMES for rehabilitation with patients who use IMDP for 
respiratory support as it does not impact the functionality of the IMDP 
systems.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case study; child; human; neuromuscular electrical stimulation; physical medicine; rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; breathing rate; case report; daily life activity; devices; disease course; education; female; functional electrical stimulation; hospital patient; male; medical record review; muscle contraction; outpatient; oxygen saturation; parameters; patient; pediatric rehabilitation; physiotherapy; positive end expiratory pressure; pulse rate; quadriplegia; range of motion; respiratory function; risk; skill; spinal cord injury; tracheostomy; vital sign; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71643497
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Neuromuscular+electrical+stimulation+is+safe+in+children+with+intramuscular+diaphragmatic+pacers%3A+A+case+series&stitle=PM+R&title=PM+and+R&volume=6&issue=9&spage=S173&epage=&aulast=Cagney&aufirst=Julie&auinit=J.&aufull=Cagney+J.&coden=&isbn=&pages=S173-&date=2014&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 401
TITLE
  Nurse with acute onset ophthalmoplegia, ataxia and dysphagia: A case report 
of bickerstaff brainstem encephalitis
AUTHOR NAMES
  Williams L.S.; Mhatre P.V.
AUTHOR ADDRESSES
  (Mhatre P.V.)
(Williams L.S.) Rehabilitation Institute of Chicago, Chicago, United States.
CORRESPONDENCE ADDRESS
  L.S. Williams, Rehabilitation Institute of Chicago, Chicago, United States.
FULL RECORD ENTRY DATE
  2014-10-31
SOURCE
  PM and R (2014) 6:9 SUPPL. 1 (S299). Date of Publication: September 2014
VOLUME
  6
ISSUE
  9
FIRST PAGE
  S299
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  2014 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: The patient initially presented with acutely worsening 
headache, neck stiffness and “jumping vision.” Physical examination 
demonstrated bilateral cranial nerve III and VI palsies, nuchal rigidity, 
tachycardia, and progressive loss of airway requiring tracheostomy and 
percutaneous endoscopic gastrostomy (PEG). After stabilization, the patient 
was admitted for acute inpatient rehabilitation with significant impairments 
in gait and self care due to visual field deficits. Her course was 
complicated by urinary retention and dysautonomia. Program Description: A 
28-year-old woman with acute onset ophthalmoplegia, ataxia, dysphagia and 
fatigue. Setting: Acute Inpatient rehabilitation. Results or Clinical 
Course: Lumbar puncture studies were inconclusive and MRI brain/spine 
revealed hyperintensities throughout the brainstem, particularly the 
medulla, and upper cervical spinal cord. She was treated for delirium/mood 
disturbance and noted to have transient hemisensory deficits. The 
constellation of acute onset ataxia and ophthalmoplegia were consistent with 
a possible diagnosis of Bickerstaff Brainstem Encephalitis (BBE). 
Discussion: This rare autoimmune disease is thought to be an unusual variant 
of acute idiopathic polyneuritis. The predominant central nervous system 
findings distinguish this condition from Fisher Syndrome, a subset of 
Guillain Barre Syndrome. It is often triggered by a preceding infection and 
has spontaneous recovery. The patient progressed from initial functional 
independence measures of total assistance to modified and complete 
independence after 4 weeks of intensive physical, occupational and speech 
therapies. Her central vestibular dysfunction improved with vestibular 
therapies. Prior to transition to outpatient, the patient was decannulated, 
tolerating oral nutrition and Foley decatheterization, with plans for full 
neuropsychiatric testing. Conclusions: BBE is a rare transient autoimmune 
disease with unique presentation that responds well to aggressive inpatient 
rehabilitation and vestibular therapies. Although known for spontaneous 
recovery, no studies exist on rehabilitation outcomes for these patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain stem; case report; dysphagia; encephalitis; human; nurse; ophthalmoplegia; physical medicine; rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  airway; autoimmune disease; central nervous system; cervical spinal cord; cranial nerve; diagnosis; disease course; dysautonomia; fatigue; female; Functional Independence Measure; gait; Guillain Barre syndrome; headache; hospital patient; independence; infection; jumping; laryngeal mask; lumbar puncture; neck; neuritis; nuclear magnetic resonance imaging; nutrition; outpatient; paralysis; patient; percutaneous endoscopic gastrostomy; physical examination; rigidity; self care; speech therapy; tachycardia; therapy; tracheostomy; urine retention; vestibular disorder; visual field; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71643824
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Nurse+with+acute+onset+ophthalmoplegia%2C+ataxia+and+dysphagia%3A+A+case+report+of+bickerstaff+brainstem+encephalitis&stitle=PM+R&title=PM+and+R&volume=6&issue=9&spage=S299&epage=&aulast=Mhatre&aufirst=Priya+V.&auinit=P.V.&aufull=Mhatre+P.V.&coden=&isbn=&pages=S299-&date=2014&auinit1=P&auinitm=V
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 402
TITLE
  Craniocervical junction dural arteriovenous fistula misdiagnosed as 
transverse myelitis: A case report
AUTHOR NAMES
  Raverty M.K.; Boyle S.; Beck L.
AUTHOR ADDRESSES
  (Boyle S.; Beck L.)
(Raverty M.K.) University of Minnesota, Medical School, Minneapolis, United 
States.
CORRESPONDENCE ADDRESS
  M.K. Raverty, University of Minnesota, Medical School, Minneapolis, United 
States.
FULL RECORD ENTRY DATE
  2014-10-31
SOURCE
  PM and R (2014) 6:9 SUPPL. 1 (S316-S317). Date of Publication: September 
2014
VOLUME
  6
ISSUE
  9
FIRST PAGE
  S316
LAST PAGE
  S317
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  2014 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: A 67-year-old man was admitted to inpatient rehabilitation 
following 3-4 months of progressive quadriparesis. He was diagnosed with 
transverse myelitis and treated with intravenous steroids and plasma 
exchange at an outside facility prior to rehabilitation admission. After 
approximately 4 months of rehabilitation, he had an acute exacerbation of 
weakness. He was treated with additional intravenous steroids and plasma 
exchange, but did not achieve the same level of function prior to 
exacerbation. After discharge home, the patient experienced a second 
exacerbation of weakness, prompting additional investigation at a tertiary 
care hospital. At that time, approximately 15 months after initial 
diagnosis, an arteriovenous dural fistula was noted at the craniocervical 
junction. He subsequently underwent craniotomy for disconnection of the 
fistula, as well as tracheostomy and gastrostomy tube placement, and was 
ultimately readmitted to acute inpatient rehabilitation. Setting: Spinal 
cord injury rehabilitation unit at Veteran's Affairs hospital Results or 
Clinical Course: Following readmission to acute rehabilitation, the patient 
continued to improve functionally with ongoing progress toward weaning 
ventilatory support and was transitioning to oral diet. Unfortunately, he 
did not achieve the level of functional independence attained prior to the 
first recurrence of symptoms. Discussion: Transverse myelitis is a 
heterogenous group of inflammatory disorders of the spinal cord that respond 
well to intravenous steroids in the majority of cases. Recurrence is rare 
and when it occurs, alternative diagnoses must be explored. Other autoimmune 
disorders with similar presentations were excluded in this case. 
Arteriovenous dural fistulas are a known cause of progressive myelopathy. A 
fistula was not identified in this case until the patient sustained further 
functional impairments and increased weakness. Thus, earlier detection of 
such vascular malformations can improve prognosis and minimize functional 
impairments. Conclusions: In cases of recurrent or progressive transverse 
myelitis, or those that do not respond well to steroids, it is important to 
pursue alternate diagnoses in order to initiate appropriate treatment and 
minimize progression of functional impairments and morbidity.
EMTREE DRUG INDEX TERMS
  steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; dural arteriovenous fistula; human; myelitis; physical medicine; rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  autoimmune disease; congenital blood vessel malformation; craniotomy; diagnosis; diet; disease course; diseases; fistula; functional disease; hospital; hospital patient; hospital readmission; independence; male; morbidity; patient; plasmapheresis; prognosis; quadriplegia; spinal cord; spinal cord disease; spinal cord injury; stomach tube; tertiary care center; tracheostomy; veteran; weakness; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71643869
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Craniocervical+junction+dural+arteriovenous+fistula+misdiagnosed+as+transverse+myelitis%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=6&issue=9&spage=S316&epage=S317&aulast=Boyle&aufirst=Stephanie&auinit=S.&aufull=Boyle+S.&coden=&isbn=&pages=S316-S317&date=2014&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 403
TITLE
  Adolescent diagnosed with spinal muscular atrophy with respiratory distress 
type 1: A case report
AUTHOR NAMES
  Khromouchkine N.; Mayer M.P.
AUTHOR ADDRESSES
  (Mayer M.P.)
(Khromouchkine N.) University of Missouri, Kansas City School of Medicine, 
Kansas City, United States.
CORRESPONDENCE ADDRESS
  N. Khromouchkine, University of Missouri, Kansas City School of Medicine, 
Kansas City, United States.
FULL RECORD ENTRY DATE
  2014-10-31
SOURCE
  PM and R (2014) 6:9 SUPPL. 1 (S381). Date of Publication: September 2014
VOLUME
  6
ISSUE
  9
FIRST PAGE
  S381
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  2014 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: A 16-year-old diagnosed with Spinal Muscular Atrophy with 
Respiratory Distress Type 1 (SMARD1) at 15 years of age, who is presently 
modified-independent in the classroom and active in the community. During 
childhood, this patient achieved independent ambulation by 3 years of age. 
Despite tracheostomy and ventilator dependence, language development was 
essentially normal. Fine motor limitations progressed and by 9 years of age 
the patient was using dictation software to remain independent in the 
classroom. Progressive weakness resulted in the loss of ambulation by 13 
years of age, and the patient now requires minimal assistance with transfers 
and a power wheelchair for independent mobility. Setting: Tertiary care 
pediatric hospital. Results or Clinical Course: This patient's diagnostic 
odyssey consisted of years of extensive testing including multiple 
electromyograms, a liver biopsy, nerve biopsy, two muscle biopsies and 
multiple genetic panels. At 15 years of age, whole exome genetic testing 
identified disease-causing compound heterozygous mutations of the IGHMBP2 
gene. Discussion: SMARD1 is a rare genetic disease manifested in early 
infancy primarily by severe diaphragmatic weakness, respiratory distress, 
and distal neuromuscular weakness due to mutations in the IGHMBP2 gene. 
Respiratory failure occurs prior to six months of age and few patients 
survive beyond childhood. This 16-year-old patient represents one of the 
oldest reported living patients with SMARD1 and has well-preserved 
independent function. The patient was diagnosed with next-generation genetic 
testing that was not available at the time of the patient's birth. 
Conclusions: With advanced respiratory care, survival beyond childhood is 
possible for patients with SMARD1. For patients with rare genetic 
conditions, whole exome testing has the potential to avoid extensive workups 
involving tests which may be invasive, expensive and delay the speed of 
diagnosis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adolescent; case report; human; physical medicine; rehabilitation; respiratory distress; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  childhood; community; diagnosis; disease course; exome; gene; genetic disorder; genetic screening; infancy; language development; liver biopsy; mobilization; muscle biopsy; mutation; nerve biopsy; patient; pediatric hospital; respiratory care; respiratory failure; software; survival; tertiary health care; tracheostomy; velocity; ventilator; weakness; wheelchair; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71644035
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Adolescent+diagnosed+with+spinal+muscular+atrophy+with+respiratory+distress+type+1%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=6&issue=9&spage=S381&epage=&aulast=Mayer&aufirst=Matthew+P.&auinit=M.P.&aufull=Mayer+M.P.&coden=&isbn=&pages=S381-&date=2014&auinit1=M&auinitm=P
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 404
TITLE
  A review of respiratory management in spinal cord injuries
AUTHOR NAMES
  Haylett R.; Gustafson O.; Fox V.; Barker G.
AUTHOR ADDRESSES
  (Haylett R.; Gustafson O.) John Radcliffe Hospital, Physiotherapy, Oxford, 
United Kingdom.
(Fox V.; Barker G.) John Radcliffe Hospital, Adult Intensive Care Unit, 
Oxford, United Kingdom.
CORRESPONDENCE ADDRESS
  R. Haylett, John Radcliffe Hospital, Physiotherapy, Oxford, United Kingdom.
FULL RECORD ENTRY DATE
  2014-10-04
SOURCE
  Intensive Care Medicine (2014) 40:1 SUPPL. 1 (S285). Date of Publication: 
September 2014
VOLUME
  40
ISSUE
  1
FIRST PAGE
  S285
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  27th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2014
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2014-09-27 to 2014-10-01
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  INTRODUCTION. No UK guidelines currently exist to inform best practice in 
the management of patients with a traumatic cervical spinal cord injury 
(SCI), particularly regarding ventilatory management in the acute stage. 
There is limited data available concerning the outcomes of specific 
management pathways or adverse events encountered, leading to individual 
centres adopting local strategies. OBJECTIVES. To review the respiratory 
management of cervical SCI patients admitted to a single general ICU in the 
UK. METHODS. Retrospective data collection and analysis of all 21 patients 
admitted to the intensive care unit following a SCI, between October 2010 
and April 2014. Clinical data was collated from the electronic notes system, 
including the time from admission to tracheostomy, number of failed 
extubations, and number of adverse events associated with failed 
extubations. The cost of respiratory physiotherapy associated with periods 
of selfventilation, post re-intubation and post tracheostomy was also 
analysed. RESULTS. 16 patients admitted during the review period suffered a 
cervical SCI. Of those surviving to ICU discharge, 11 (85 %) received a 
tracheostomy. Of those not receiving a tracheostomy, one patient was never 
intubated and transferred to a spinal injury centre within one week. One 
suffered an incomplete lower cervical SCI that showed rapid neurological 
recovery post spinal stabilisation. Three patients died. There were 12 
failed extubations, an average of 1.7 per patient. Patients that were 
extubated spent on average 1.4 days self ventilating, and received an 
average 8.9 h of physiotherapy input in this time (6.4 h per day). During 
periods post re-intubation, patients spent on average 5.5 days receiving 
mechanical ventilation, with an average 14.7 h of physiotherapy input during 
this time (2.7 h per day). There were complications associated with failed 
extubations and re-intubations. These include frequent episodes of 
physiotherapy and lung volume recruitment/airway clearance, one emergency 
tracheostomy to manage a difficult airway, one pneumothorax, and two 
bronchoscopies. There were no adverse events post tracheostomy. The average 
time from admission to receiving a tracheostomy was nine days. Patients then 
spent on average 22.4 days with the tracheostomy, and received an average of 
35 h of therapy in this time (1.6 h per day). CONCLUSIONS. This limited 
review suggests that the majority of patients admitted to this general ICU 
with a cervical SCI will benefit from a tracheostomy to facilitate weaning 
from mechanical ventilation and physiotherapy management. A delay in 
tracheostomy and subsequent failed extubations are associated with several 
adverse events. Those that receive a tracheostomy experience fewer 
respiratory complications and the cost related to respiratory physiotherapy 
is reduced.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; society; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  airway; artificial ventilation; breathing exercise; bronchoscopy; cervical spinal cord injury; clinical study; emergency; extubation; human; information processing; intensive care unit; intubation; lung volume; patient; physiotherapy; pneumothorax; spine injury; therapy; tracheostomy; United Kingdom; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71630841
DOI
  10.1007/s00134-013-3451-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-013-3451-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-013-3451-5&atitle=A+review+of+respiratory+management+in+spinal+cord+injuries&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=40&issue=1&spage=S285&epage=&aulast=Haylett&aufirst=R.&auinit=R.&aufull=Haylett+R.&coden=&isbn=&pages=S285-&date=2014&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 405
TITLE
  Traumatic spinal cord injury in a military hospital in Saudi Arabia
AUTHOR NAMES
  Al Jadid M.
AUTHOR ADDRESSES
  (Al Jadid M.) Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
CORRESPONDENCE ADDRESS
  M. Al Jadid, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
FULL RECORD ENTRY DATE
  2014-10-31
SOURCE
  PM and R (2014) 6:9 SUPPL. 1 (S212-S213). Date of Publication: September 
2014
VOLUME
  6
ISSUE
  9
FIRST PAGE
  S212
LAST PAGE
  S213
DATE OF PUBLICATION
  September 2014
CONFERENCE NAME
  2014 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-11-13 to 2014-11-16
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Objective: To determine the causes, age and gender differences, hospital 
length of stay (HLoS), and prevalence of traumatic spinal cord injury (TSCI) 
for patients admitted to a military hospital in Saudi Arabia. Design: This 
was a retrospective study. All patients who completed the TSCI 
rehabilitation program at the Rehabilitation Unit at Prince Sultan Military 
Medical City, Riyadh, Kingdom of Saudi Arabia from August 1982 to November 
2010 were included. The admission criteria includes: stable medical 
condition, no pressure sore, no tracheostomy, and not more than 3 patients 
with quadriplegia in the unit at any time due to the loads on patients. 
Setting: Saudi referral trauma center. Participants: 466 patients (398 males 
and 68 females). Interventions: All patients were involved in total of 3 
hours of physical and occupational therapy daily during the working days. 
Main Outcome Measures: Type and mechanism of trauma, type and severity of 
neurologic deficits, causes, frequency and HLoS. Results or Clinical Course: 
Compared to females, the frequency of TSCI was higher in males. The higher 
frequency of TSCI was found in the 16-30 age group, and a lower frequency 
was found in the 0-15 and >45 age groups. Out of the 466 TSCI patients 377 
(80.1%) sustained their injuries as a result from motor vehicle accidents. 
Cervical cord was the most common site of injury accounting for 34% (n=137) 
of cases in male population, and in females, the higher frequency was the 
upper thoracic (n=31 [45.6%]) There were 250 TSCI patients that stayed in 
the hospital for 1-70 days, and only 12 patients stayed in hospital for >280 
days. Conclusions: Compared to females, the frequency of TSCI was higher in 
males, and younger group sustained more TSCI. Road traffic accident is the 
most common cause of injury, and more than 50% of the TSCI patients stayed 
in the hospital for <70 days.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  physical medicine; public hospital; rehabilitation; Saudi Arabia; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  army; cervical spinal cord; city; decubitus; disease course; emergency health service; female; groups by age; hospital; human; injury; length of stay; male; occupational therapy; patient; population; prevalence; quadriplegia; retrospective study; sex difference; tracheostomy; traffic; traffic accident; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71643597
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Traumatic+spinal+cord+injury+in+a+military+hospital+in+Saudi+Arabia&stitle=PM+R&title=PM+and+R&volume=6&issue=9&spage=S212&epage=S213&aulast=Al+Jadid&aufirst=Maher&auinit=M.&aufull=Al+Jadid+M.&coden=&isbn=&pages=S212-S213&date=2014&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 406
TITLE
  Screening for proteinuria in 'at-risk' patients with spinal cord injuries: 
Lessons learnt from failure
AUTHOR NAMES
  Vaidyanathan S.; Abraham K.A.; Singh G.; Soni B.; Hughes P.
AUTHOR ADDRESSES
  (Vaidyanathan S., subramanian.vaidyanathan@nhs.net; Soni B., 
bakul.soni@nhs.net) Regional Spinal Injuries Centre, Southport and Formby 
District General Hospital, Town Lane, Southport PR8 6PN, United Kingdom.
(Abraham K.A., abraham.abraham@aintree.nhs.uk) Department of Renal Medicine, 
Southport and Formby District General Hospital, Town Lane, Southport PR8 
6PN, United Kingdom.
(Singh G., gurpreet.singh@nhs.net) Department of Urology, Southport and 
Formby District General Hospital, Town Lane, Southport PR8 6PN, United 
Kingdom.
(Hughes P., peterhughes1@nhs.net) Department of Radiology, Southport and 
Formby District General Hospital, Town Lane, Southport PR8 6PN, United 
Kingdom.
CORRESPONDENCE ADDRESS
  S. Vaidyanathan, Regional Spinal Injuries Centre, Southport and Formby 
District General Hospital, Town Lane, Southport PR8 6PN, United Kingdom. 
Email: subramanian.vaidyanathan@nhs.net
AiP/IP ENTRY DATE
  2014-08-01
FULL RECORD ENTRY DATE
  2014-08-06
SOURCE
  Patient Safety in Surgery (2014) 8:1 Article Number: 25. Date of 
Publication: 9 Jun 2014
VOLUME
  8
ISSUE
  1
DATE OF PUBLICATION
  9 Jun 2014
ISSN
  1754-9493 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Spinal cord injury patients may develop proteinuria as a result of 
glomerulosclerosis due to urosepsis, hydronephrosis, vesicoureteric reflux, 
and renal calculi. Proteinuria in turn contributes to progression of kidney 
disease. We report one paraplegic and two tetraplegic patients, who 
developed recurrent urine infections, urinary calculi, and hydronephrosis. 
These patients required several urological procedures (nephrostomy, 
cystoscopy and ureteric stenting, ureteroscopy and lithotripsy, 
extracorporeal shock wave lithotripsy). These patients had not received 
antimuscarinic drugs nor had they undergone video-urodynamics. Proteinuria 
was detected only at a late stage, as testing for proteinuria was not 
performed during follow-up visits. Urine electrophoresis showed no 
monoclonal bands in any; Serum glomerular basement membrane antibody screen 
was negative. Serum neutrophil cytoplasmic antibodies screen by fluorescence 
was negative. All patients were prescribed Ramipril 2.5 mg daily and there 
was no further deterioration of renal function.Spinal cord injury patients, 
who did not receive antimuscarinic drugs to reduce intravesical pressure, 
are at high risk for developing reflux nephropathy. When such patients 
develop glomerulosclerosis due to recurrent urosepsis, renal calculi, or 
hydronephrosis, risk of proteinuria is increased further. Take home message: 
(1) Screening for proteinuria should be performed regularly in the 'at-risk' 
patients. (2) In the absence of other renal diseases causing proteinuria, 
spinal cord injury patients with significant proteinuria may be prescribed 
angiotensin-converting enzyme inhibitor or angiotensin-II receptor 
antagonist to slow progression of chronic renal disease and reduce the risk 
of cardiovascular mortality. © 2014 Vaidyanathan et al.; licensee BioMed 
Central Ltd.
EMTREE DRUG INDEX TERMS
  amikacin (drug therapy); ampicillin (drug therapy); atorvastatin; creatinine (endogenous compound); distigmine (drug therapy); gentamicin (drug therapy); hemoglobin (endogenous compound); hemoglobin A1c (endogenous compound); metronidazole (drug therapy); neutrophil cytoplasmic antibody (endogenous compound); phenoxybenzamine (drug therapy); piperacillin plus tazobactam (drug therapy); prazosin (drug therapy, oral drug administration); ramipril (adverse drug reaction, drug therapy); urea (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  high risk patient; proteinuria (drug therapy, complication, drug therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  absence of side effects (side effect); adult; antibiotic therapy; article; balloon dilatation; cervical spine dislocation; clinical article; computer assisted tomography; cystography; cystoscopy; disease course; Enterococcus faecalis; extracorporeal shock wave lithotripsy; glomerulosclerosis; glomerulus basement membrane; glomerulus filtration rate; human; hydronephrosis (diagnosis, surgery, therapy); indwelling catheter; kidney abscess (drug therapy); kidney cyst; kidney disease; kidney function; lung infiltrate (drug therapy); male; nephrolithiasis; nephrostomy tube; orchitis; quadriplegia; rigor; screening test; Streptococcus milleri; tracheostomy; ureter stent; ureter stone (surgery, therapy); ureteropelvic junction obstruction; ureteroscopy; urinary tract infection (drug therapy); urosepsis; vesicoureteral reflux (complication, diagnosis, drug therapy, surgery, 
therapy); vomiting; 
CAS REGISTRY NUMBERS
  amikacin (37517-28-5, 39831-55-5)
  ampicillin (69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0)
  atorvastatin (134523-00-5, 134523-03-8)
  creatinine (19230-81-0, 60-27-5)
  distigmine (17299-00-2)
  gentamicin (1392-48-9, 1403-66-3, 1405-41-0)
  hemoglobin (9008-02-0)
  hemoglobin A1c (62572-11-6)
  metronidazole (39322-38-8, 443-48-1)
  phenoxybenzamine (59-96-1, 63-92-3)
  prazosin (19216-56-9, 19237-84-4)
  ramipril (87333-19-5)
  urea (57-13-6)
EMBASE CLASSIFICATIONS
  Urology and Nephrology (28)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014493888
PUI
  L373599489
DOI
  10.1186/1754-9493-8-25
FULL TEXT LINK
  http://dx.doi.org/10.1186/1754-9493-8-25
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17549493&id=doi:10.1186%2F1754-9493-8-25&atitle=Screening+for+proteinuria+in+%27at-risk%27+patients+with+spinal+cord+injuries%3A+Lessons+learnt+from+failure&stitle=Patient+Saf.+Surg.&title=Patient+Safety+in+Surgery&volume=8&issue=1&spage=&epage=&aulast=Vaidyanathan&aufirst=Subramanian&auinit=S.&aufull=Vaidyanathan+S.&coden=&isbn=&pages=-&date=2014&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 407
TITLE
  Tetraplegia incidence in Normandy
AUTHOR NAMES
  Quesnel A.; Beuret Blanquart F.; Proust F.; Verin E.
AUTHOR ADDRESSES
  (Quesnel A.; Verin E.) CRMPR les Herbiers, CHU de Rouen, Bois-Guillaume, 
France.
(Beuret Blanquart F.) CRMPR les Herbiers, CHU de Rouen, rue de Germont, 
Rouen cedex, France.
(Proust F.) Service de Neurochirurgie, CHU de Rouen, 1, rue de Germont, 
Rouen cedex, France.
CORRESPONDENCE ADDRESS
  A. Quesnel, CRMPR les Herbiers, CHU de Rouen, Bois-Guillaume, France.
FULL RECORD ENTRY DATE
  2014-07-09
SOURCE
  Annals of Physical and Rehabilitation Medicine (2014) 57 SUPPL. 1 
(e227-e228). Date of Publication: May 2014
VOLUME
  57
FIRST PAGE
  e227
LAST PAGE
  e228
DATE OF PUBLICATION
  May 2014
CONFERENCE NAME
  19th European Congress of Physical and Rehabilitation Medicine
CONFERENCE LOCATION
  Marseille, France
CONFERENCE DATE
  2014-05-26 to 2014-05-31
ISSN
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS
ABSTRACT
  We conducted a retrospective study on patients over 18 years with traumatic 
cervical spinal cord injury level in Upper Normandy, between 2002 and 2012. 
One hundred and eight patients were included (49.0±21.1 years), with an 
increase in the proportion of falls. The male/female ratio is 3.9 males to 1 
female, with the level most frequently found the C5 level, then the C6 
level, C4 level, the C7 level, the level C8 and C3 level; 27.8% of patients 
were admitted in ICU, and 40.7% had a tracheotomy, which 56.8% were able to 
be weaned from their tracheotomy; 6.5% required permanent mechanical 
ventilatory support. The incidence of admissions in ICU of post-traumatic 
tetraplegia was calculated at 12.7 and 13.4 cases per million inhabitants, 
stable for the years 2009, 2010, 2011 and 2012. This study shows that taking 
into account the ventilated quadriplegic remains difficult, and the creation 
of a national health sector would serve as a dedicated use for patients and 
supporting the teams throughout the territory.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia; rehabilitation medicine; 
EMTREE MEDICAL INDEX TERMS
  cervical spinal cord injury; female; human; male; patient; public health; retrospective study; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71517490
DOI
  10.1016/j.rehab.2014.03.834
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2014.03.834
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770657&id=doi:10.1016%2Fj.rehab.2014.03.834&atitle=Tetraplegia+incidence+in+Normandy&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=57&issue=&spage=e227&epage=e228&aulast=Quesnel&aufirst=A.&auinit=A.&aufull=Quesnel+A.&coden=&isbn=&pages=e227-e228&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 408
TITLE
  Continuous Positive Airway Pressure (CPAP) for prevention of recurrent 
pneumonia in the Neuromyelitis Optica patient
AUTHOR NAMES
  Welker J.A.
AUTHOR ADDRESSES
  (Welker J.A., jimwelker@hotmail.com) University of Maryland School of 
Medicine, Anne Arundel Health System, Baltimore, MD, United States.
CORRESPONDENCE ADDRESS
  J.A. Welker, Anne Arundel Medical Center, 2001 Medical Parkway, Annapolis, 
MD 21401, United States. Email: jimwelker@hotmail.com
AiP/IP ENTRY DATE
  2014-04-16
FULL RECORD ENTRY DATE
  2014-04-23
SOURCE
  Respiratory Medicine Case Reports (2014) 12 (34-36). Date of Publication: 1 
May 2014
VOLUME
  12
FIRST PAGE
  34
LAST PAGE
  36
DATE OF PUBLICATION
  1 May 2014
ISSN
  2213-0071 (electronic)
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Introduction: Traumatic spinal cord injury patients with quadriplegia 
associated respiratory compromise are at an immediately increased risk of 
developing pneumonia, but the onset of pneumonia risk and use of prevention 
strategies in the patient with quadriplegia due to Neuromyelitis Optica has 
not been described. Case report: This is a case of a Neuromyelitis Optica 
patient with quadriplegia, dysphagia and tracheostomy that suffered 
recurrent fevers due to respiratory infections. The non-specific 
presentation and test results led to extensive testing, while the frequent 
recurrence resulted in the patient residing in the acute care hospital 201 
days and outside of this hospital only 118 days during the period of August 
2011 to June 2012. The initiation of CPAP 10cm while sleeping overnight for 
8-10heliminated the recurrence of respiratory infections and thereby reduced 
both the frequency and duration of the patient's hospital stays. 
Conclusions: Patients with Neuromyelitis Optica differ from those with 
traumatic spinal cord injury as they have a chronic progressive systemic 
illness that causes continued deterioration of their nervous system 
resulting in the need for routine monitoring that ensures the timely 
addition of CPAP for the prevention of pneumonia and its associated medical 
expenses. © 2014 The Authors.
EMTREE DRUG INDEX TERMS
  antibiotic agent (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myelooptic neuropathy; pneumonia (prevention, therapy); positive end expiratory pressure; 
EMTREE MEDICAL INDEX TERMS
  adult; antibiotic therapy; article; atelectasis; bladder dysfunction; breathing muscle; case report; daily life activity; decubitus; deep vein thrombosis; drug fever (side effect); drug withdrawal; dysphagia; feeding apparatus; female; hemidiaphragm; hormone substitution; hospital; hospitalization; human; hypopituitarism; hypothalamus; hypoventilation; leg disease; leg paralysis; muscle strength; myelitis; nursing home patient; osteomyelitis; priority journal; quadriplegia; recurrent fever; recurrent infection; respiratory failure; respiratory tract infection; sleep; suprapubic catheter; thorax radiography; tracheostomy; urinary tract infection; 
EMBASE CLASSIFICATIONS
  Ophthalmology (12)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014241441
PUI
  L372772537
DOI
  10.1016/j.rmcr.2013.12.009
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rmcr.2013.12.009
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22130071&id=doi:10.1016%2Fj.rmcr.2013.12.009&atitle=Continuous+Positive+Airway+Pressure+%28CPAP%29+for+prevention+of+recurrent+pneumonia+in+the+Neuromyelitis+Optica+patient&stitle=Respir.+Med.+Case+Rep.&title=Respiratory+Medicine+Case+Reports&volume=12&issue=&spage=34&epage=36&aulast=Welker&aufirst=James+A.&auinit=J.A.&aufull=Welker+J.A.&coden=&isbn=&pages=34-36&date=2014&auinit1=J&auinitm=A
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 409
TITLE
  Difficult-to-wean: High index of suspicion
AUTHOR NAMES
  Gelaye A.; Patel B.; Farra W.; Kole B.
AUTHOR ADDRESSES
  (Gelaye A., alehegn.gelaye@gmail.com; Patel B.) Department of Internal 
Medicine, Providence Hospital and Medical Center, Southfield, MI, United 
States.
(Farra W.) Department of Pulmonary and Critical Care Medicine, Providence 
Hospital and Medical Center, Southfield, MI, United States.
(Kole B.) Department of Neurology, Providence Hospital and Medical Center, 
Southfield, MI, United States.
CORRESPONDENCE ADDRESS
  A. Gelaye, Department of Internal Medicine, Providence Hospital and Medical 
Center, Southfield, MI, United States. Email: alehegn.gelaye@gmail.com
AiP/IP ENTRY DATE
  2014-05-09
FULL RECORD ENTRY DATE
  2014-05-20
SOURCE
  American Journal of Case Reports (2014) 15 (163-167). Date of Publication: 
22 Apr 2014
VOLUME
  15
FIRST PAGE
  163
LAST PAGE
  167
DATE OF PUBLICATION
  22 Apr 2014
ISSN
  1941-5923 (electronic)
BOOK PUBLISHER
  Medical Science International
ABSTRACT
  Objective: Rare disease Background: Failed planned extubation occurs in a 
minority of patients with acute respiratory failure requiring invasive 
mechanical ventilation. In patients presenting with acute respiratory 
failure with no identifiable cardiopulmonary causes, uncommon conditions, 
such as cervical spondylotic myelopathy, should be considered. In very rare 
instances, when cervical spondylotic myelopathy and syringomyelia present 
concomitantly, they can be devastating. Case Report: A 57-year-old woman 
visited the emergency room (ER) after feeling unwell for several days. She 
was brought to the ER with acute respiratory distress and obtunded state 
with GCS of 6/ 15. She was hypotensive and agonally breathing. Her initial 
neurologic evaluation was unrevealing. Based on these findings, she was 
intubated. Over the next several days, she was difficult to wean from the 
ventilator and had persistent respiratory acidosis. After a short-lived 
extubation, the patient was again re-intubated. This time the neurologic 
evaluation showed decreased movements of all muscle groups against gravity 
and forces, with generalized weakness. An MRI of the brain and cervical 
spine demonstrated moderate degenerative disc disease and syringomyelia 
extending from C2 to C7 level. The patient underwent de-compression 
laminectomy. After failing several weaning trials, she underwent 
bronchoscopically-assisted tracheotomy. Conclusions: Acute cardiopulmonary 
and intensive care unit-acquired neuromuscular conditions have been 
attributed as a major cause of difficult weaning and extubation. Failure to 
identify and correct other rare combinations (such as cervical degenerative 
disc disease and syringomyelia) may cause acute respiratory failure and 
subsequent failure to wean and extubation, resulting in high rates of 
mortality and morbidity. © Am J Case Rep, 2014.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; intervertebral disk disease (diagnosis, surgery); syringomyelia (diagnosis, surgery); treatment failure; 
EMTREE MEDICAL INDEX TERMS
  adult; arterial gas; article; breathing rate; bronchoscopy; case report; cervical spondylotic myelopathy (diagnosis); clinical feature; decompression surgery; diagnostic imaging; disease association; disease course; extubation; female; Glasgow coma scale; heart rate; human; image analysis; laminectomy; mechanical ventilator; medical history; middle aged; muscle weakness (diagnosis); neuroimaging; neurologic examination; nuclear magnetic resonance imaging; outcome assessment; patient assessment; quadriplegia (diagnosis); respiratory acidosis (diagnosis); respiratory distress (therapy); tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014299834
PUI
  L372984641
DOI
  10.12659/AJCR.890284
FULL TEXT LINK
  http://dx.doi.org/10.12659/AJCR.890284
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19415923&id=doi:10.12659%2FAJCR.890284&atitle=Difficult-to-wean%3A+High+index+of+suspicion&stitle=Am.+J.+Case+Rep.&title=American+Journal+of+Case+Reports&volume=15&issue=&spage=163&epage=167&aulast=Gelaye&aufirst=Alehegn&auinit=A.&aufull=Gelaye+A.&coden=&isbn=&pages=163-167&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 410
TITLE
  Cervico-dorsal intramedullary hematoma in a patient with pompe disease
AUTHOR NAMES
  Nadile D.; Toledo M.G.; Tamargo A.; Cassara F.P.; Thomson A.; Muñoz F.; Klein F.
AUTHOR ADDRESSES
  (Cassara F.P.)
(Toledo M.G.; Klein F.) Buenos Aires, Argentina.
(Tamargo A.) Institute of Neurosciences, Buenos Aires, Argentina.
(Nadile D.; Thomson A.; Muñoz F.) Institute of Neurosciences at Favaloro 
Foundation, Buenos Aires, Argentina.
CORRESPONDENCE ADDRESS
  D. Nadile, Institute of Neurosciences at Favaloro Foundation, Buenos Aires, 
Argentina.
FULL RECORD ENTRY DATE
  2014-05-27
SOURCE
  Neurology (2014) 82:10 SUPPL. 1. Date of Publication: 8 Apr 2014
VOLUME
  82
ISSUE
  10
DATE OF PUBLICATION
  8 Apr 2014
CONFERENCE NAME
  66th American Academy of Neurology Annual Meeting, AAN 2014
CONFERENCE LOCATION
  Philadelphia, PA, United States
CONFERENCE DATE
  2014-04-26 to 2014-05-03
ISSN
  0028-3878
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  OBJECTIVE: To suggest that Pompe Disease can cause microvascular alterations 
that may also affect the spinal cord.BACKGROUND: Pompe disease (PD) or acid 
maltase deficiency leads to accumulation of glycogen in different tissues, 
particularly in skeletal muscle. Late-onset forms have a progressive 
evolution in elderly patients. An alteration in the cerebral 
microvasculature has been described in this group, leading to cerebral 
bleeding.DESIGN/METHODS: 83-year-old woman with diagnosis of PD. She 
pesented with a history of 20 years of progressive generalized weakness 
predominantly in proximal muscles of lower limbs, and diaphragmatic 
paralysis, leading to respiratory failure requiring tracheostomy and chronic 
mechanical ventilation. She was admitted for a left moderate braquiocrural 
motordeficit and left upper limb sensitive deficit as well. A brain CT 
discarded hemorrhagic or ischemic lesions. 48 hours later she added left 
upper and lower limb plegia, right severe upper and lower limb paresis and a 
sensitive level at D 4.RESULTS: The neck vessel Doppler and Cardiac Doppler 
showed no significant findings. Cervical and dorsal MRI was performed 
showing an heterogeniclesion extending from the medulla to D6, that is 
hypointense in T1 and hyperintense on T2 , FLAIR andGrE, compatible with 
intramedullary spinal hematoma. A selective spinal angiography discarded any 
vascular malformation.CONCLUSIONS: Late onset Pompe disease may be 
associated with spontaneous cerebral hemorrhages even in the absence of 
typical cardiovascular risk factors. These patients may have glycogen 
deposits in the tunica media of arteriolar walls, with vacuolar degeneration 
and formation of microaneurysms that predisposes spontaneous cerebral 
hemorrhage . While basilar dolichoectasia and vascular malformations in the 
posterior territory are described as an association to hemorrhagic lesions 
in this population, in our case, this was ruled out by a digital 
angiography. There are numerous reports of brain intraparenchymal hematomas 
associated with PD but not in the topography above mentioned.
EMTREE DRUG INDEX TERMS
  glucan 1,4 alpha glucosidase; glycogen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  glycogen storage disease type 2; hematoma; human; neurology; patient; 
EMTREE MEDICAL INDEX TERMS
  aged; arm; artificial ventilation; brain; brain hemorrhage; cardiovascular risk; congenital blood vessel malformation; degeneration; diagnosis; diaphragm paralysis; digital subtraction angiography; female; leg; microvasculature; muscle; neck; nuclear magnetic resonance imaging; paresis; population; respiratory failure; skeletal muscle; spinal angiography; spinal hematoma; tissues; topography; tracheostomy; tunica media; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71468171
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00283878&id=doi:&atitle=Cervico-dorsal+intramedullary+hematoma+in+a+patient+with+pompe+disease&stitle=Neurology&title=Neurology&volume=82&issue=10&spage=&epage=&aulast=Cassara&aufirst=Fatima+Pagani&auinit=F.P.&aufull=Cassara+F.P.&coden=&isbn=&pages=-&date=2014&auinit1=F&auinitm=P
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 411
TITLE
  Strengthened respiratory management for lower tracheostomy risks in patients 
with complete cervical spinal cord injury
AUTHOR NAMES
  Zhu W.; Kan L.; Sun Y.; Chen X.; Yuan W.; Jia L.
AUTHOR ADDRESSES
  (Zhu W.; Kan L.; Sun Y.; Chen X.; Yuan W.; Jia L., jialianshun@163.com) 
Department of Spinal Surgery, Shanghai Changzheng Hospital, Shanghai 200003, 
China.
CORRESPONDENCE ADDRESS
  L. Jia, Department of Spinal Surgery, Shanghai Changzheng Hospital, Shanghai 
200003, China. Email: jialianshun@163.com
AiP/IP ENTRY DATE
  2014-04-29
FULL RECORD ENTRY DATE
  2014-05-07
SOURCE
  National Medical Journal of China (2014) 94:13 (999-1002). Date of 
Publication: 8 Apr 2014
VOLUME
  94
ISSUE
  13
FIRST PAGE
  999
LAST PAGE
  1002
DATE OF PUBLICATION
  8 Apr 2014
ISSN
  0376-2491
BOOK PUBLISHER
  Chinese Medical Association
ABSTRACT
  Objective: To access the feasibility of reducing tracheostomy rates in 
patients with complete cervical spinal cord injury through a systemic 
respiratory management mode. Methods: A retrospective review was performed 
for 239 patients on a systemic respiratory management mode after complete 
cervical spinal cord injury in Shanghai Changzheng Hospital from 2006 to 
2012. Their demographic and clinical data, including age, gender, cause of 
injury, level of cervical spinal cord injuries, surgical approaches, 
tracheostomy rates and mortality rates, were collected and analyzed. 
Tracheostomy rates were compared with those of patients with complete 
cervical spinal cord injury. Tracheostomy rates were compared with those 
patients with complete cervical spinal cord injury from 1991 to 2005. The 
new respiratory management mode for patients with severe cervical spinal 
cord injury included maintaining adequate energy and water for patients, 
relieving bronchospasm, loosening phlegm, strengthening body-turning and 
hackslapping, sputum aspiration with suction tube through nasal cavity or 
bronchofibroscope, strengthening deep breath and cough training, strict 
control of tracheostomy indications and short-term postoperative intubation 
reserving if necessary. Results: 32 patients were implemented tracheostomy. 
The tracheostomy rate was 13.4%. 10 patients died, the mortality rate was 
4.18%. However, the tracheostomy rate was 19.1% and mortality rate 21.4% 
from 1991 to 2005. The tracheostomy rate was significantly lower than before 
and survival rate improved significantly. Conclusion: The systemic 
respiratory management mode can effectively reduce tracheostomy rate of 
patients with complete cervical spinal cord injury and improve their 
survival rate. Copyright © 2014 by the Chinese Medical Association.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  age; article; breathing; bronchospasm; demography; feasibility study; gender; human; major clinical study; medical record review; mortality; risk reduction; surgical technique; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  English, Chinese
EMBASE ACCESSION NUMBER
  2014272690
MEDLINE PMID
  24851687 (http://www.ncbi.nlm.nih.gov/pubmed/24851687)
PUI
  L372870891
DOI
  10.3760/cma.j.issn.0376-2491.2014.13.011
FULL TEXT LINK
  http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2014.13.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03762491&id=doi:10.3760%2Fcma.j.issn.0376-2491.2014.13.011&atitle=Strengthened+respiratory+management+for+lower+tracheostomy+risks+in+patients+with+complete+cervical+spinal+cord+injury&stitle=Nat.+Med.+J.+China&title=National+Medical+Journal+of+China&volume=94&issue=13&spage=999&epage=1002&aulast=Zhu&aufirst=Wei&auinit=W.&aufull=Zhu+W.&coden=&isbn=&pages=999-1002&date=2014&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 412
TITLE
  Innominate artery injury: A catastrophic complication of tracheostomy, 
operative procedure revisited
AUTHOR NAMES
  Maruti Pol M.; Gupta A.; Kumar S.; Mishra B.
AUTHOR ADDRESSES
  (Maruti Pol M., manjunath.pol@gmail.com) Department of Trauma Surgery, All 
India Institute of Medical Sciences, New Delhi, India.
(Gupta A.; Kumar S.; Mishra B.) Department of Trauma Surgery (Surgical 
Disciplines), J.P.N.Apex Trauma Centre, All India Institute of Medical 
Sciences, New Delhi, India.
CORRESPONDENCE ADDRESS
  M. Maruti Pol, Department of Trauma Surgery, All India Institute of Medical 
Sciences, New Delhi, India. Email: manjunath.pol@gmail.com
AiP/IP ENTRY DATE
  2014-04-25
FULL RECORD ENTRY DATE
  2014-05-02
SOURCE
  BMJ Case Reports (2014) Article Number: 201628. Date of Publication: 3 Apr 
2014
DATE OF PUBLICATION
  3 Apr 2014
ISSN
  1757-790X (electronic)
BOOK PUBLISHER
  BMJ Publishing Group, subscriptions@bmjgroup.com
ABSTRACT
  A patient presented with profuse bleeding from the oronasal cavity following 
orofaciomaxillary trauma associated with tracheolaryngeal injury and 
suspected cervical-spine injury due to collapse of a wall on the face, neck 
and upper chest. The patient was gasping, coughing blood and was unable to 
speak. Threatened airway was diagnosed. Inability to maintain oxygenation on 
cricothyroidotomy, forced emergency department surgeons to shift the patient 
to the operating room for definitive airway. During tracheostomy a major 
vessel was injured. Application of vascular clamp in the event of achieving 
haemostasis resulted in disappearance of saturation and pulse in the right 
upper limb, thus we suspected innominate artery (IA) injury. High 
tracheostomy performed and endotracheal tube passed into the trachea after 
removing clot and overcoming compromised narrow tracheal lumen. The injured 
IA was repaired and the patient survived for 14 days. On postoperative day 
14 he died following profound bleeding into the tracheobronchial tree and 
asphyxia/ apnoea. Tracheoinnominate artery fistula was detected at autopsy. 
Copyright 2014 BMJ Publishing Group. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artery injury (complication); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aortic aneurysm (diagnosis); article; autopsy; blood transfusion; blood vessel injury (diagnosis); blunt trauma; case report; crystalloid; death; differential diagnosis; emphysema; extubation; false aneurysm (diagnosis); human; human tissue; hypoxia (complication); intensive care unit; larynx injury; male; multiple trauma; nech vascular anomaly (diagnosis); oral bleeding; outcome assessment; peroperative care; postoperative care; priority journal; surgical approach; surgical technique; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014261028
MEDLINE PMID
  24700033 (http://www.ncbi.nlm.nih.gov/pubmed/24700033)
PUI
  L372838192
DOI
  10.1136/bcr-2013-201628
FULL TEXT LINK
  http://dx.doi.org/10.1136/bcr-2013-201628
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1757790X&id=doi:10.1136%2Fbcr-2013-201628&atitle=Innominate+artery+injury%3A+A+catastrophic+complication+of+tracheostomy%2C+operative+procedure+revisited&stitle=BMJ+Case+Rep.&title=BMJ+Case+Reports&volume=&issue=&spage=&epage=&aulast=Maruti+Pol&aufirst=Manjunath&auinit=M.&aufull=Maruti+Pol+M.&coden=&isbn=&pages=-&date=2014&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 413
TITLE
  Chordoma: A rare cause of progressive neurologic symptoms and Horner's 
syndrome
AUTHOR NAMES
  Hovaida M.M.
AUTHOR ADDRESSES
  (Hovaida M.M.) UCSD, San Diego, United States.
CORRESPONDENCE ADDRESS
  M.M. Hovaida, UCSD, San Diego, United States.
FULL RECORD ENTRY DATE
  2014-06-17
SOURCE
  Journal of General Internal Medicine (2014) 29 SUPPL. 1 (S333). Date of 
Publication: April 2014
VOLUME
  29
FIRST PAGE
  S333
DATE OF PUBLICATION
  April 2014
CONFERENCE NAME
  37th Annual Meeting of the Society of General Internal Medicine, SGIM 2014
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-04-23 to 2014-04-26
ISSN
  0884-8734
BOOK PUBLISHER
  Springer New York
ABSTRACT
  LEARNING OBJECTIVE 1: Recognize chordomas as rare bone tumors that commonly 
present as chronic, progressive neurologic symptoms refractory to routine 
management LEARNING OBJECTIVE 2: Coordinate multidisciplinary care for 
complex patients CASE: A 59 year old female with history of morbid obesity, 
diabetes mellitus complicated by CKDIII, hypertension and OSA presented to 
her primary internist with persistent left arm and neck pain and tingling 
for 9 months refractory to physical therapy that prevented her from typing 
at work. She also complained of dry eyes and progressive shortness of 
breath, previously attributed to worsening OSA with uptitration of her CPAP 
settings. Physical exam was notable for an obese Hispanic female with left 
neck fullness and left miosis and ptosis consistent with Horner's syndrome. 
CT neck/thorax demonstrated a large, infiltrating pre-vertebral mass 
extending 20 cm from the lower clivus to the upper chest, displacing the 
trachea, posterior to the descending aorta and encasing the left subclavian, 
vertebral and common carotid artery. The patient was referred to ENT with 
laryngoscopy showing a patent but narrowed airway. Subsequent tracheostomy 
with exploration and biopsy identified metastatic adenocarcinoma on frozen 
section. However, formal pathology identified a classic type chordoma with 
cytokeratin and EMA positivity. Radiation Oncology recommended maximal 
resection with post-operative proton beam radiotherapy to residual disease 
and areas at risk for recurrence. Coordinated tumor de-bulking and spinal 
cord decompression was performed by Orthopedics, Neurosurgery and ENT, 
however tumor could only be partially removed due to high risk location. 
Repeat imaging demonstrated residual tumor within the spinal canal at the 
cervico-thoracic junction and mediastinum. She underwent 30 sessions of 
radiation, although repeat imaging showed increased tumor size and necrosis. 
Patient's course was also complicated by multiple ED visits and 
hospitalizations for pain control, neurologic complaints and infection 
requiring close follow-up with her primary. After multiple discussions, 
patient and family requested focus on comfort-oriented treatment and was 
subsequently enrolled in hospice, although she was discharged after 6 months 
given her stable clinical status. DISCUSSION: Chordomas are rare bone tumors 
characterized by slow growth, frequent local recurrence and rare systemic 
spread. They arise from embryonic remnants of the notochord and can be 
spheno-occipital (35 %), vertebral (15 %), or sacro-coccygeal (50 %). 
Approximately 7-10 % of chordomas are cervical and typically present in the 
5th-6th decade without gender predilection. Nerve impingement, progressive 
pain and headaches are common symptoms. Radiographically, chordomas are 
usually solitary, lytic lesions ranging from 1 to 10 cm. In this case, the 
large size and considerable extension of the tumor were uncommon. 
Immunohistochemistry typically demonstrates positivity for EMA or 
cytokeratin. Initial treatment consists of wide, local excision, which is 
associated with longer survival and delayed recurrence, although as in this 
case, complete resection is often difficult secondary to involvement of 
vital structures and thus adjuvant radiation is employed. Limited literature 
reviews of molecular based therapy have also demonstrated symptomatic, and 
rarely, radiological response. Ultimately, chordomas are challenging to 
manage and often require a multi-disciplinary approach, demonstrating the 
importance of the primary provider in care coordination, advocacy and 
ongoing assessment of patient symptoms and goals of care through this 
complicated course.
EMTREE DRUG INDEX TERMS
  adjuvant; cytokeratin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chordoma; Horner syndrome; internal medicine; neurologic disease; society; 
EMTREE MEDICAL INDEX TERMS
  adenocarcinoma; airway; arm; biopsy; bone tumor; clivus; comfort; common carotid artery; descending aorta; diabetes mellitus; dry eye; dyspnea; female; follow up; frozen section; gender; headache; Hispanic; hospice; hospitalization; human; hypertension; imaging; immunohistochemistry; infection; internist; laryngoscopy; mediastinum; minimal residual disease; miosis; morbid obesity; neck; neck pain; necrosis; neoplasm; nerve; neurosurgery; notochord; oncology; orthopedics; otorhinolaryngology; pain; patent; pathology; patient; physiotherapy; positive end expiratory pressure; proton therapy; ptosis (eyelid); radiation; risk; spinal cord decompression; surgery; survival; therapy; thorax; trachea; tracheostomy; tumor volume; vertebral canal; wide excision; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71495481
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08848734&id=doi:&atitle=Chordoma%3A+A+rare+cause+of+progressive+neurologic+symptoms+and+Horner%27s+syndrome&stitle=J.+Gen.+Intern.+Med.&title=Journal+of+General+Internal+Medicine&volume=29&issue=&spage=S333&epage=&aulast=Hovaida&aufirst=Marjan+M.&auinit=M.M.&aufull=Hovaida+M.M.&coden=&isbn=&pages=S333-&date=2014&auinit1=M&auinitm=M
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 414
TITLE
  Mortality and morbidity after high-dose methylprednisolone treatment in 
patients with acute cervical spinal cord injury: A propensity-matched 
analysis using a nationwide administrative database
AUTHOR NAMES
  Chikuda H.; Yasunaga H.; Takeshita K.; Horiguchi H.; Kawaguchi H.; Ohe K.; Fushimi K.; Tanaka S.
AUTHOR ADDRESSES
  (Chikuda H., chikuda-tky@umin.ac.jp; Takeshita K.; Kawaguchi H.; Tanaka S.) 
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
(Yasunaga H.; Horiguchi H.) Department of Health Management and Policy, 
Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
(Ohe K.) Department of Medical Informatics and Economics, Graduate School of 
Medicine, University of Tokyo, Tokyo, Japan.
(Fushimi K.) Department of Health Care Informatics, Tokyo Medical and Dental 
University, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  H. Chikuda, Department of Orthopaedic Surgery, Faculty of Medicine, 
University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Email: 
chikuda-tky@umin.ac.jp
AiP/IP ENTRY DATE
  2013-03-12
FULL RECORD ENTRY DATE
  2014-03-05
SOURCE
  Emergency Medicine Journal (2014) 31:3 (201-206). Date of Publication: March 
2014
VOLUME
  31
ISSUE
  3
FIRST PAGE
  201
LAST PAGE
  206
DATE OF PUBLICATION
  March 2014
ISSN
  1472-0205
  1472-0213 (electronic)
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  Objective To examine the magnitude of the adverse impact of high-dose 
methylprednisolone treatment in patients with acute cervical spinal cord 
injury (SCI). Methods We examined the abstracted data from the Japanese 
Diagnosis Procedure Combination database, and included patients with ICD-10 
code S141 who were admitted on an emergency basis between 1 July and 31 
December in 2007-2009. The investigation evaluated the patients' sex, age, 
comorbidities, Japan Coma Scale, hospital volume and the amount of 
methylprednisolone administered. One-to-one propensity-score matching 
between high-dose methylprednisolone group (>5000 mg) and control group was 
performed to compare the rates of in-hospital death and major complications 
(sepsis; pneumonia; urinary tract infection; gastrointestinal 
ulcer/bleeding; and pulmonary embolism). Results We identified 3508 cervical 
SCI patients (2652 men and 856 women; mean age, 60.8±18.7 years) including 
824 (23.5%) patients who received high-dose methylprednisolone. A 
propensity-matched analysis with 824 pairs of patients showed a significant 
increase in the occurrence of gastrointestinal ulcer/bleeding (68/812 vs 
31/812; p<0.001) in the high-dose methylprednisolone group. Overall, the 
high-dose methylprednisolone group demonstrated a significantly higher risk 
of complications (144/812 vs 96/812;OR, 1.66; 95% CI 1.23 to 2.24; p=0.001) 
than the control group. There was no significant difference in in-hospital 
mortality between the high-dose methylprednisolone group and the control 
group ( p=0.884). Conclusions Patients receiving high-dose 
methylprednisolone had a significantly increased risk of major 
complications, in particular, gastrointestinal ulcer/bleeding. However, 
high-dose methylprednisolone treatment was not associated with any increase 
in mortality.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  methylprednisolone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (drug therapy, drug therapy, surgery); morbidity; mortality; 
EMTREE MEDICAL INDEX TERMS
  adult; age; aged; article; Charlson Comorbidity Index; comorbidity; controlled study; digestive system ulcer (complication); drug megadose; emergency care; female; gastrointestinal hemorrhage (complication); gender; hospital admission; human; ICD-10; Japan Coma Scale; length of stay; lung embolism (complication); major clinical study; male; pneumonia (complication); priority journal; propensity score; rating scale; risk assessment; sepsis (complication); spine surgery; steroid therapy; tracheostomy; urinary tract infection (complication); very elderly; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014132410
MEDLINE PMID
  23449889 (http://www.ncbi.nlm.nih.gov/pubmed/23449889)
PUI
  L52483611
DOI
  10.1136/emermed-2012-202058
FULL TEXT LINK
  http://dx.doi.org/10.1136/emermed-2012-202058
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14720205&id=doi:10.1136%2Femermed-2012-202058&atitle=Mortality+and+morbidity+after+high-dose+methylprednisolone+treatment+in+patients+with+acute+cervical+spinal+cord+injury%3A+A+propensity-matched+analysis+using+a+nationwide+administrative+database&stitle=Emerg.+Med.+J.&title=Emergency+Medicine+Journal&volume=31&issue=3&spage=201&epage=206&aulast=Chikuda&aufirst=Hirotaka&auinit=H.&aufull=Chikuda+H.&coden=EMJMB&isbn=&pages=201-206&date=2014&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 415
TITLE
  Brown-Vialetto-van Laere syndrome: A riboflavin responsive neuronopathy of 
infancy with singular features
AUTHOR NAMES
  Spagnoli C.; Pitt M.C.; Rahman S.; De Sousa C.
AUTHOR ADDRESSES
  (Spagnoli C., carlotta.spagnoli@gmail.com; De Sousa C.) Great Ormond Street 
Hospital for Children, Neuroscience Department, Great Ormond Street, London 
WC1N 3JH, United Kingdom.
(Pitt M.C.) Neurophysiology Department, Great Ormond Street Hospital for 
Children, London, United Kingdom.
(Rahman S.) Metabolic Department, Great Ormond Street Hospital for Children, 
London, United Kingdom.
(Rahman S.) Mitochondrial Research Group, UCL Institute of Child Health, 
London, United Kingdom.
CORRESPONDENCE ADDRESS
  C. Spagnoli, Great Ormond Street Hospital for Children, Neuroscience 
Department, Great Ormond Street, London WC1N 3JH, United Kingdom. Email: 
carlotta.spagnoli@gmail.com
AiP/IP ENTRY DATE
  2013-10-31
FULL RECORD ENTRY DATE
  2014-03-18
SOURCE
  European Journal of Paediatric Neurology (2014) 18:2 (231-234). Date of 
Publication: March 2014
VOLUME
  18
ISSUE
  2
FIRST PAGE
  231
LAST PAGE
  234
DATE OF PUBLICATION
  March 2014
ISSN
  1090-3798
  1532-2130 (electronic)
BOOK PUBLISHER
  W.B. Saunders Ltd, 32 Jamestown Road, London, United Kingdom.
ABSTRACT
  We report the case of a previously healthy child presenting at 6 months of 
age with mild feeding difficulties and then developing hypotonia, 
progressive bulbar palsy with respiratory compromise and lower motor neuron 
signs, causing her to spend 4 months in the Paediatric Intensive Care Unit. 
Neurophysiological studies demonstrated a motor neuronopathy involving 
anterior horn cells and cranial nerve nuclei and abnormal brainstem auditory 
evoked potentials, leading to a diagnosis of Brown-Vialetto-van Laere 
Syndrome, confirmed by genetic testing (SLC52A3). Magnetic Resonance Imaging 
showed signal changes in the dorsal column of the spinal cord. She developed 
a coarse face and abnormal hair pattern. Sustained clinical improvement has 
been observed during almost 4 years of high-dose riboflavin therapy. © 2013 
European Paediatric Neurology Society. Published by Elsevier Ltd. All rights 
reserved.
EMTREE DRUG INDEX TERMS
  acylcarnitine (endogenous compound); carboxylic acid (endogenous compound); citrate synthase (endogenous compound); cytochrome c oxidase (endogenous compound); immunoglobulin (intravenous drug administration); riboflavin; ubidecarenone; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Brown Vialetto van Laere syndrome (diagnosis, etiology); infant disease (diagnosis, etiology); riboflavin deficiency (diagnosis, etiology); 
EMTREE MEDICAL INDEX TERMS
  anterior horn cell; article; assisted ventilation; atelectasis; bulbar paralysis; case report; cervical spinal cord; chest infection; coarse face; cranial nerve; diaphragm paralysis; electromyography; enzyme activity; evoked brain stem auditory response; fasciculation; feeding difficulty; female; frameshift mutation; gastrostomy; genetic screening; hair disease; histochemistry; human; human tissue; infant; lipid blood level; missense mutation; motoneuron; muscle action potential; muscle biopsy; muscle denervation; muscle hypotonia; muscle strength; muscle weakness; neuroimaging; neurologic examination; neurophysiological recruitment; neurophysiology; newborn intensive care; nuclear magnetic resonance imaging; ophthalmoplegia; perception deafness; priority journal; ptosis (eyelid); respiratory failure (therapy); seizure; tendon reflex; tracheostomy; urine level; walker; 
CAS REGISTRY NUMBERS
  citrate synthase (9027-96-7)
  cytochrome c oxidase (72841-18-0, 9001-16-5)
  immunoglobulin (9007-83-4)
  riboflavin (83-88-5)
  ubidecarenone (303-98-0)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014156202
MEDLINE PMID
  24206674 (http://www.ncbi.nlm.nih.gov/pubmed/24206674)
PUI
  L52834067
DOI
  10.1016/j.ejpn.2013.09.006
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ejpn.2013.09.006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10903798&id=doi:10.1016%2Fj.ejpn.2013.09.006&atitle=Brown-Vialetto-van+Laere+syndrome%3A+A+riboflavin+responsive+neuronopathy+of+infancy+with+singular+features&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=18&issue=2&spage=231&epage=234&aulast=Spagnoli&aufirst=Carlotta&auinit=C.&aufull=Spagnoli+C.&coden=EJPNF&isbn=&pages=231-234&date=2014&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 416
TITLE
  Recombinant human β-glucuronidase enzyme replacement therapy for 
mucopolysaccharidosis type VII: Report of the first patient treated
AUTHOR NAMES
  Fox J.E.; Kakkis E.D.; Sly W.S.
AUTHOR ADDRESSES
  (Fox J.E.) Steven and Alexandra Cohen Children's Medical Center, New York, 
United States.
(Kakkis E.D.) Ultragenyx Pharmaceutical Inc, Novato, United States.
(Sly W.S.) St. Louis University, School of Medicine, St. Louis, United 
States.
CORRESPONDENCE ADDRESS
  J.E. Fox, Steven and Alexandra Cohen Children's Medical Center, New York, 
United States.
FULL RECORD ENTRY DATE
  2015-03-12
SOURCE
  Molecular Genetics and Metabolism (2014) 111:2 (S44). Date of Publication: 
February 2014
VOLUME
  111
ISSUE
  2
FIRST PAGE
  S44
DATE OF PUBLICATION
  February 2014
CONFERENCE NAME
  10th Annual Research Meeting of the Lysosomal Disease Network, WORLD 
Symposium, 2014
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2014-02-10 to 2014-02-13
ISSN
  1096-7192
BOOK PUBLISHER
  Academic Press Inc.
ABSTRACT
  Mucopolysaccharidosis type VII (MPS VII, Sly syndrome), is a very rare 
lysosomal disease, caused by deficiency of beta-glucuronidase (GUS), 
required for the degradation of dermatan sulfate and heparan sulfate. 
Clinically, this multi-systemic disorder resembles MPS I and MPS II, 
howevermarked heterogeneity of presentation and progression has been noted. 
Two decades of animal research demonstrate effective treatment with enzyme 
replacement therapy (ERT) in MPS VII mouse models. Furthermore, there are 
extensive data on approved ERT in three other MPS disorders. However, there 
is no product approved for treatment of MPS VII patients. We present the 
clinical features of the first patient with MPS VII who was recently infused 
with recombinant human GUS (rhGUS) as ERT. The patient is an 12 year old boy 
diagnosed with MPS VII by fibroblast assay, consistent with the clinical 
features including hydrops fetalis, hepatosplenomegaly, heart valve disease, 
frequent sinopulmonary infections and upper airway obstruction, declining 
pulmonary function, dysostosis multiplex, and spinal cord compression 
requiring cervical fusion. His urinary glycosaminoglycan levels were 
significantly elevated, at >4x the upper limit of normal, at baseline. 
Despite a tracheostomy, nocturnal CPAP and oxygen therapy, significant 
pulmonary restriction and obstruction led to oxygen dependence, rising CO(2) 
levels in the 60-80 range, approaching respiratory failure and the need for 
full-time ventilation. Since no additional medical measures could improve 
his function, we implemented experimental ERT by infusing rhGUS at 2 mg/kg 
over 4 hours every 2weeks, after pretreatment with an oral antihistamine. To 
evaluate his response to therapy, urinary GAG levels, pulmonary function, 
oxygen dependence, CO(2) levels, cardiac valve function, liver and spleen 
size, and growth velocitywill be assessed. Safety will be evaluated by 
standard assessments and observance of any infusion-related reactions. Data 
on efficacy and safety in this first report of ERT in MPS VII will be 
reported.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  beta glucuronidase; 
EMTREE DRUG INDEX TERMS
  antihistaminic agent; dermatan sulfate; glycosaminoglycan; heparan sulfate; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  enzyme replacement; human; mucopolysaccharidosis type 7; patient; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; assay; boy; clinical feature; diseases; fetus hydrops; fibroblast; heart valve; hepatosplenomegaly; Hurler syndrome; infection; infusion related reaction; liver; lung function; male; mouse; mouse model; obstruction; oxygen therapy; positive end expiratory pressure; respiratory failure; safety; spinal cord compression; spleen size; systemic disease; therapy; tracheostomy; upper respiratory tract obstruction; valvular heart disease; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71805059
DOI
  10.1016/j.ymgme.2013.12.088
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ymgme.2013.12.088
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10967192&id=doi:10.1016%2Fj.ymgme.2013.12.088&atitle=Recombinant+human+%CE%B2-glucuronidase+enzyme+replacement+therapy+for+mucopolysaccharidosis+type+VII%3A+Report+of+the+first+patient+treated&stitle=Mol.+Genet.+Metab.&title=Molecular+Genetics+and+Metabolism&volume=111&issue=2&spage=S44&epage=&aulast=Fox&aufirst=Joyce+E.&auinit=J.E.&aufull=Fox+J.E.&coden=&isbn=&pages=S44-&date=2014&auinit1=J&auinitm=E
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 417
TITLE
  Risk factors for prolonged duration of mechanical ventilation in acute 
traumatic tetraplegic patients-a retrospective cohort study
AUTHOR NAMES
  Roquilly A.; Seguin P.; Mimoz O.; Feuillet F.; Rosenczweig E.; Chevalier F.; Loutrel O.; Malledant Y.; Sebille V.; Asehnoune K.
AUTHOR ADDRESSES
  (Roquilly A.; Loutrel O.; Asehnoune K., karim.asehnoune@chu-nantes.fr) 
Intensive Care Unit, Anesthesia and Critical Care Department, Hôtel 
Dieu-HME, Univ. Hosp. of Nantes and UPRES EA 3826: Therapeutiques cliniques 
et experimentales des infections, Nantes, France.
(Seguin P.; Malledant Y.) Intensive Care Unit, Anesthesia and Critical Care 
Department, University Hospital of Rennes and INSERM U991 Foie, métabolisme 
et cancer, Rennes, France.
(Mimoz O.; Chevalier F.) Intensive Care Unit, Anesthesia and Critical Care 
Department, University Hospital of Poitiers, France and INSERM U1070, 
Poitiers, France.
(Feuillet F.; Sebille V.) Cellule de Biostatistique, CHU Nantes-EA 4275-UFR 
de Pharmacie, University of Nantes, Nantes, France.
(Rosenczweig E.) Medical Intensive Care Unit, HÔtel Dieu-HME, University 
Hospital of Nantes, Nantes, France.
CORRESPONDENCE ADDRESS
  K. Asehnoune, Centre Hospitalier Universitaire de Nantes, Service Anesthésie 
Réanimation Chirurgicale, HÔtel Dieu-HME, Nantes, France. Email: 
karim.asehnoune@chu-nantes.fr
AiP/IP ENTRY DATE
  2014-01-13
FULL RECORD ENTRY DATE
  2014-03-13
SOURCE
  Journal of Critical Care (2014) 29:2 (313.e7-313.e13). Date of Publication: 
February 2014
VOLUME
  29
ISSUE
  2
DATE OF PUBLICATION
  February 2014
ISSN
  0883-9441
  1557-8615 (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Purpose: Respiratory complications constitute an important determinant of 
length of stay in tetraplegic patients. In a population of tetraplegic 
patients, we investigated the factors involved in the duration of mechanical 
ventilation (MV) and whether the duration of MV was associated with the 
long-term neurologic status. Material and Methods: In a retrospective study 
in 3 intensive care units (ICUs) (January 2001 to December 2009), 
consecutive patients (≥ 18 years) hospitalized for acute (≤ 24 hours) 
traumatic tetraplegia were included in the study. Patients with severe brain 
injury or who died in the first 48 hours were excluded. The primary outcome 
was the duration of MV. The secondary outcomes were the American Spinal 
Injury Association (ASIA) motor score on ICU discharge and at 1 year. 
Results: A total of 164 consecutive adult patients with tetraplegia were 
analyzed. Median (interquartile range) ASIA motor scores were 15 (6-26) on 
admission, 22 (9-40) on ICU discharge (n = 145 survivors), and 37 (10-80) at 
1 year (n = 52 complete follow-up). The median duration of MV was 11 (2-26) 
days. In multivariate analysis, MV duration increased with pneumonia (P < 
.0001), atelectasis (P = .0042), and tracheotomy (P < .0001). In exploratory 
analysis, an increased duration of MV was the only factor associated in 
multivariate analysis with a low ASIA motor score on ICU discharge (P = 
.0201) and at 1 year (P = .0003). Conclusions: Prevention of pneumonia and 
atelectasis is critical for the reduction of MV in tetraplegic patients. 
Prolonged MV was independently associated with poor neurologic status. © 
2014 Elsevier Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; quadriplegia; 
EMTREE MEDICAL INDEX TERMS
  adult; American Spinal Injury Association impairment scale; article; atelectasis (complication, therapy); cohort analysis; female; hospital admission; hospital discharge; human; intensive care unit; major clinical study; male; middle aged; pneumonia (complication, therapy); retrospective study; risk factor; spinal cord injury; survivor; tracheotomy; treatment duration; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014150689
MEDLINE PMID
  24412010 (http://www.ncbi.nlm.nih.gov/pubmed/24412010)
PUI
  L52947803
DOI
  10.1016/j.jcrc.2013.11.021
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jcrc.2013.11.021
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08839441&id=doi:10.1016%2Fj.jcrc.2013.11.021&atitle=Risk+factors+for+prolonged+duration+of+mechanical+ventilation+in+acute+traumatic+tetraplegic+patients-a+retrospective+cohort+study&stitle=J.+Crit.+Care&title=Journal+of+Critical+Care&volume=29&issue=2&spage=&epage=&aulast=Roquilly&aufirst=Antoine&auinit=A.&aufull=Roquilly+A.&coden=JCCAE&isbn=&pages=-&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 418
TITLE
  Complete cervical spinal cord injury above C6 predicts the need for 
tracheostomy
AUTHOR NAMES
  McCully B.H.; Fabricant L.; Geraci T.; Greenbaum A.; Schreiber M.A.; Gordy S.D.
AUTHOR ADDRESSES
  (McCully B.H., houghtob@ohsu.edu; Fabricant L.; Geraci T.; Greenbaum A.; 
Schreiber M.A.; Gordy S.D.) Trauma Research Institute of Oregon, Division of 
Trauma, Critical Care and Acute Care Surgery, Oregon Health and Science 
University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States.
(Gordy S.D.) Michael E. DeBakey Department of Surgery, Baylor Medical 
College, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
CORRESPONDENCE ADDRESS
  B.H. McCully, Trauma Research Institute of Oregon, Division of Trauma, 
Critical Care and Acute Care Surgery, Oregon Health and Science University, 
3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States. Email: 
houghtob@ohsu.edu
AiP/IP ENTRY DATE
  2014-02-26
FULL RECORD ENTRY DATE
  2014-05-22
SOURCE
  American Journal of Surgery (2014) 207:5 (664-668). Date of Publication: May 
2014
VOLUME
  207
ISSUE
  5
FIRST PAGE
  664
LAST PAGE
  668
DATE OF PUBLICATION
  May 2014
ISSN
  1879-1883 (electronic)
  0002-9610
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background: Failed extubation and delayed tracheostomy contribute to poor 
outcomes in patients with a traumatic spinal cord injury (SCI). We 
determined if the level and completeness of SCI predict the need for 
tracheostomy. Methods: Data from 256 patients with SCI between C1 and T3 
with or without tracheostomy were retrospectively analyzed. Logistic 
regression identified predictors for tracheostomy. Data are presented as raw 
percentage or odds ratio (OR) with 95% confidence interval. P <.05 indicates 
significance. Results: Complete spinal cord injuries were common in patients 
requiring tracheostomy (55% vs 18%, P <.05), and predicted the need for 
tracheostomy (OR: 6.4 (3.1 to 13.5), P <.05). An injury above C6 predicted 
the need for tracheostomy in patients with complete injury (OR: 3.7 (1 to 
11.9), P <.05), but not incomplete injury (OR:.7 (.3 to 1.9); P =.53). 
Conclusion: Tracheostomy is unlikely in patients with incomplete SCI, 
regardless of the level of injury. Patients with complete SCI above C6 are 
likely to require tracheostomy. © 2014 Elsevier Inc. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; female; Glasgow coma scale; human; injury scale; injury severity; length of stay; major clinical study; male; penetrating trauma; prediction; priority journal; retrospective study; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014307638
MEDLINE PMID
  24560586 (http://www.ncbi.nlm.nih.gov/pubmed/24560586)
PUI
  L53017076
DOI
  10.1016/j.amjsurg.2014.01.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.amjsurg.2014.01.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18791883&id=doi:10.1016%2Fj.amjsurg.2014.01.001&atitle=Complete+cervical+spinal+cord+injury+above+C6+predicts+the+need+for+tracheostomy&stitle=Am.+J.+Surg.&title=American+Journal+of+Surgery&volume=207&issue=5&spage=664&epage=668&aulast=McCully&aufirst=Belinda+H.&auinit=B.H.&aufull=McCully+B.H.&coden=AJSUA&isbn=&pages=664-668&date=2014&auinit1=B&auinitm=H
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 419
TITLE
  Resection of an upper cervical aneurysmal bone cyst and spinal 
reconstruction using a midline mandibular osteotomy in a pediatric patient: 
Case report
AUTHOR NAMES
  McDowell M.M.; Hanft S.J.; Greenberg S.A.; Rahmati R.; Carrao V.; Eisig S.; Anderson R.C.E.
AUTHOR ADDRESSES
  (McDowell M.M.; Hanft S.J.; Greenberg S.A.; Anderson R.C.E., 
rca24@columbia.edu) Department of Neurological Surgery, Columbia University, 
New York, NY, United States.
(Rahmati R.) Otolaryngology-Head and Neck Surgery, Columbia University, New 
York, NY, United States.
(Carrao V.; Eisig S.) Section of Hospital Dentistry, Division of Oral and 
Maxillofacial Surgery, Columbia University, New York, NY, United States.
CORRESPONDENCE ADDRESS
  R.C.E. Anderson, Neurological Institute, 710 W. 168th St., New York, NY 
10032, United States. Email: rca24@columbia.edu
AiP/IP ENTRY DATE
  2014-06-10
FULL RECORD ENTRY DATE
  2014-06-19
SOURCE
  Journal of Neurosurgery: Pediatrics (2014) 13:6 (622-625). Date of 
Publication: June 2014
VOLUME
  13
ISSUE
  6
FIRST PAGE
  622
LAST PAGE
  625
DATE OF PUBLICATION
  June 2014
ISSN
  1933-0715 (electronic)
  1933-0707
BOOK PUBLISHER
  American Association of Neurological Surgeons, jnevro@virginia.edu
ABSTRACT
  The authors report on the surgical management of an extensive lesion of the 
upper cervical spine that required an uncommon transmandibular approach to 
facilitate exposure, resection, and stabilization in a pediatric patient. A 
6-year-old boy with a large aneurysmal bone cyst of the C-2 vertebra 
presented with progressive weakness and right-sided neck pain. The lesion 
extended laterally into the soft tissue of the neck, inferiorly to C-4, and 
posteriorly around the spinal cord. A transmandibular osteotomy was 
performed to provide adequate exposure for complete resection of the mass 
and anterior C1-3 instrumentation and fusion. Subsequently, the patient 
underwent occiput to C-4 posterior instrumentation and fusion. The patient 
tolerated the operation well and had regained all function at 3 and 11 
months' follow-up. No neurological complications or problems of speech, 
swallowing, or respiration occurred. Even in pediatric patients, the 
transmandibular approach for the treatment of upper cervical spine lesions 
is an effective method of maximizing exposure for complex lesions requiring 
resection and stabilization. ©AANS, 2014.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysmal bone cyst (diagnosis, surgery); cervical spine; mandible osteotomy; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  allograft; anesthesia induction; article; body weight loss; bone matrix; case report; child; computer assisted tomography; fluoroscopy; follow up; histology; human; incision; male; neck pain; nuclear magnetic resonance imaging; patient positioning; preschool child; priority journal; submandibular gland; surgical approach; torticollis; tracheostomy; weakness; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014374163
MEDLINE PMID
  24702619 (http://www.ncbi.nlm.nih.gov/pubmed/24702619)
PUI
  L373202149
DOI
  10.3171/2014.3.PEDS13511
FULL TEXT LINK
  http://dx.doi.org/10.3171/2014.3.PEDS13511
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19330715&id=doi:10.3171%2F2014.3.PEDS13511&atitle=Resection+of+an+upper+cervical+aneurysmal+bone+cyst+and+spinal+reconstruction+using+a+midline+mandibular+osteotomy+in+a+pediatric+patient%3A+Case+report&stitle=J.+Neursurg.+Pediatr.&title=Journal+of+Neurosurgery%3A+Pediatrics&volume=13&issue=6&spage=622&epage=625&aulast=McDowell&aufirst=Michael+M.&auinit=M.M.&aufull=McDowell+M.M.&coden=&isbn=&pages=622-625&date=2014&auinit1=M&auinitm=M
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 420
TITLE
  Risk factors relating to the need for mechanical ventilation in isolated 
cervical spinal cord injury patients
AUTHOR NAMES
  Lertudomphonwanit T.; Wattanaapisit T.; Chavasiri C.; Chotivichit A.
AUTHOR ADDRESSES
  (Lertudomphonwanit T., ryanrong@hotmail.com; Wattanaapisit T.; Chavasiri C.; 
Chotivichit A.) Department of Orthopedics Surgery, Mahidol University, 
Bangkok, Thailand.
CORRESPONDENCE ADDRESS
  T. Lertudomphonwanit, Department of Orthopedics Surgery, Ramathibodi 
Hospital, Mahidol University, Bangkok, Thailand.
AiP/IP ENTRY DATE
  2015-09-09
FULL RECORD ENTRY DATE
  2015-09-14
SOURCE
  Journal of the Medical Association of Thailand (2014) 97 Supplement 9 
(S10-S15). Date of Publication: 1 Sep 2014
VOLUME
  97
FIRST PAGE
  S10
LAST PAGE
  S15
DATE OF PUBLICATION
  1 Sep 2014
ISSN
  0125-2208 (electronic)
  0125-2208
BOOK PUBLISHER
  Medical Association of Thailand, math@loxinfo.co.th
ABSTRACT
  Background: Cervical spinal cord injuries (SCI) are a major public health 
problem. Respiratory complications are among the most important causes of 
morbidity and mortality in patients with cervical SCI, especially 
respiratory failure. Based on our evaluation of the existing English 
language literature, few previous studies appear to have reported on risk 
factors associated with the need for mechanical ventilation in isolated 
cervical SCI patients who had no concomitant injuries or diseases at the 
time of admission. Objective: The purpose of this study was to determine 
incidence and risk factors relating to the need for mechanical ventilation 
in isolated cervical spinal cord injury (SCI) patients who had no 
concomitant injuries. Material and Method: This retrospective study was 
conducted by reviewing and analyzing the patient data of 66 isolated 
cervical-SCI patients who were admitted in our hospital between January 1995 
and December 2009. Patient medical records were reviewed for demographic 
data, neurological injuries, need for mechanical ventilation, definitive 
treatment, complications, and outcomes. Univariate and multivariate analysis 
were used to identify predisposing risk factors relating to patient 
dependency on mechanical ventilation. Results: Of the 66 patients, 30.3% 
(20/66) required mechanical ventilation and 22.7% (15/66) were identified as 
complete cord injury, of which seven sustained injury above C5. Of the 
patients with complete SCI, 66.7% (10/15) were dependent on mechanical 
ventilation, as were 85% (6/7) with SCI above C5. All five of the patients 
with complete-SCI above C5 who received operative treatment were dependent 
upon mechanical ventilation, postoperatively. Only 19.6% (10/51) of the 
incomplete injury group required mechanical ventilation. Univariate analysis 
indicated the following factors as significantly increasing the risk of 
ventilator dependence: complete SCI (p = 0.001), SCI above C5 level (p = 
0.011) and operative treatment (p = 0.008). Multivariate analysis identified 
the following factors as being predisposing risk factors relating to the 
need of mechanical ventilation: complete SCI (OR: 12.8; 95% CI 2.4-66.9; p = 
0.003), SCI above C5 level (OR: 12.0; 95% CI 2.4-60.2; p = 0.002), and 
operative treatment (OR: 14.8; 95% CI 2.1-106.9; p = 0.008). Conclusion: 
Complete SCI, SCI above C5, and operative treatment were predisposing risk 
factors relating to the need for mechanical ventilation in isolated cervical 
SCI patients. The data and findings put forth in this study suggest that 
these factors may assist in predicting the need for mechanical ventilation 
as a long-term treatment for isolated cervical SCI patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; American Spinal Injury Association impairment scale; article; child; female; hospital admission; human; major clinical study; male; medical record; mortality; pneumonia; respiratory failure; respiratory tract infection; retrospective study; risk factor; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, Thai
EMBASE ACCESSION NUMBER
  2015352255
MEDLINE PMID
  25365883 (http://www.ncbi.nlm.nih.gov/pubmed/25365883)
PUI
  L605899622
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01252208&id=doi:&atitle=Risk+factors+relating+to+the+need+for+mechanical+ventilation+in+isolated+cervical+spinal+cord+injury+patients&stitle=J.+Med.+Assoc.+Thailand&title=Journal+of+the+Medical+Association+of+Thailand&volume=97&issue=&spage=S10&epage=S15&aulast=Lertudomphonwanit&aufirst=Thamrong&auinit=T.&aufull=Lertudomphonwanit+T.&coden=JMTHB&isbn=&pages=S10-S15&date=2014&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 421
TITLE
  A review article on the benefits of early mobilization following spinal 
surgery and other medical/surgical procedures
AUTHOR NAMES
  Epstein N.E.
AUTHOR ADDRESSES
  (Epstein N.E., nancy.epsteinmd@gmail.com) Chief of Neurosurgical Research 
and Education, Winthrop University Hospital, Mineola, United States.
CORRESPONDENCE ADDRESS
  N.E. Epstein, Chief of Neurosurgical Research and Education, Winthrop 
University Hospital, Mineola, United States. Email: 
nancy.epsteinmd@gmail.com
AiP/IP ENTRY DATE
  2017-06-07
FULL RECORD ENTRY DATE
  2017-06-12
SOURCE
  Surgical Neurology International (2014) 5:4 Supplement 3 (S66-S73). Date of 
Publication: 2014
VOLUME
  5
ISSUE
  4
FIRST PAGE
  S66
LAST PAGE
  S73
DATE OF PUBLICATION
  2014
ISSN
  2152-7806 (electronic)
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Background: The impact of early mobilization on perioperative comorbidities 
and length of stay (LOS) has shown benefits in other medical/surgical 
subspecialties. However, few spinal series have specifically focused on the 
«pros» of early mobilization for spinal surgery, other than in acute spinal 
cord injury. Here we reviewed how early mobilization and other adjunctive 
measures reduced morbidity and LOS in both medical and/or surgical series, 
and focused on how their treatment strategies could be applied to spinal 
patients. Methods: We reviewed studies citing protocols for early 
mobilization of hospitalized patients (day of surgery, first postoperative 
day/other) in various subspecialties, and correlated these with patients 
perioperative morbidity and LOS. As anticipated, multiple comorbid factors 
(e.g. hypertension, high cholesterol, diabetes, hypothyroidism, 
obesity/elevated body mass index hypothyroidism, osteoporosis, chronic 
obstructive pulmonary disease, coronary artery disease and other factors) 
contribute to the risks and complications of immobilization for any 
medical/surgical patient, including those undergoing spinal procedures. Some 
studies additionally offered useful suggestions specific for spinal 
patients, including prehabilitation (e.g. rehabilitation that starts prior 
to surgery), preoperative and postoperative high protein supplements/drinks, 
better preoperative pain control, and early tracheostomy, while others cited 
more generalized recommendations. Results: In many studies, early 
mobilization protocols reduced the rate of complications/morbidity (e.g. 
respiratory decompensation/pneumonias, deep venous thrombosis/pulmonary 
embolism, urinary tract infections, sepsis or infection), along with the 
average LOS. Conclusions: A review of multiple medical/surgical protocols 
promoting early mobilization of hospitalized patients including those 
undergoing spinal surgery reduced morbidity and LOS.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  medical procedures; mobilization; spine surgery; surgical technique; 
EMTREE MEDICAL INDEX TERMS
  body mass; chronic obstructive lung disease; clinical protocol; coronary artery disease; correlation analysis; deep vein thrombosis (complication, prevention); diabetes mellitus; hospital patient; human; hypercholesterolemia; hypertension; hypothyroidism; length of stay; lung embolism (complication, prevention); morbidity; obesity; osteoporosis; patient; peroperative complication (complication); pneumonia (complication, prevention); postoperative infection (complication, prevention); preoperative treatment; priority journal; protein intake; respiratory tract disease (complication, prevention); review; sepsis (complication, prevention); supplementation; surgical patient; tracheostomy; urinary tract infection (complication, prevention); 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20170397187
PUI
  L616576964
DOI
  10.4103/2152-7806.130674
FULL TEXT LINK
  http://dx.doi.org/10.4103/2152-7806.130674
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2F2152-7806.130674&atitle=A+review+article+on+the+benefits+of+early+mobilization+following+spinal+surgery+and+other+medical%2Fsurgical+procedures&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=5&issue=4&spage=S66&epage=S73&aulast=Epstein&aufirst=Nancy+E.&auinit=N.E.&aufull=Epstein+N.E.&coden=&isbn=&pages=S66-S73&date=2014&auinit1=N&auinitm=E
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 422
TITLE
  A review article on the benefits of early mobilization following spinal 
surgery and other medical/surgical procedures
AUTHOR NAMES
  Epstein N.E.
AUTHOR ADDRESSES
  (Epstein N.E., nancy.epsteinmd@gmail.com) Chief of Neurosurgical Research 
and Education, Winthrop University Hospital, Mineola, NY 11501, United 
States.
CORRESPONDENCE ADDRESS
  N.E. Epstein, Chief of Neurosurgical Research and Education, Winthrop 
University Hospital, Mineola, NY 11501, United States. Email: 
nancy.epsteinmd@gmail.com
AiP/IP ENTRY DATE
  2014-09-10
FULL RECORD ENTRY DATE
  2014-09-13
SOURCE
  Surgical Neurology International (2014) 5:SUPPL. 3 (S66-S73). Date of 
Publication: 2014
VOLUME
  5
ISSUE
  SUPPL. 3
DATE OF PUBLICATION
  2014
ISSN
  2152-7806 (electronic)
ABSTRACT
  Background: The impact of early mobilization on perioperative comorbidities 
and length of stay (LOS) has shown benefits in other medical/surgical 
subspecialties. However, few spinal series have specifically focused on the 
"pros" of early mobilization for spinal surgery, other than in acute spinal 
cord injury. Here we reviewed how early mobilization and other adjunctive 
measures reduced morbidity and LOS in both medical and/or surgical series, 
and focused on how their treatment strategies could be applied to spinal 
patients. Methods: We reviewed studies citing protocols for early 
mobilization of hospitalized patients (day of surgery, first postoperative 
day/other) in various subspecialties, and correlated these with patients′ 
perioperative morbidity and LOS. As anticipated, multiple comorbid factors 
(e.g. hypertension, high cholesterol, diabetes, hypothyroidism, 
obesity/elevated body mass index hypothyroidism, osteoporosis, chronic 
obstructive pulmonary disease, coronary artery disease and other factors) 
contribute to the risks and complications of immobilization for any 
medical/surgical patient, including those undergoing spinal procedures. Some 
studies additionally offered useful suggestions specific for spinal 
patients, including prehabilitation (e.g. rehabilitation that starts prior 
to surgery), preoperative and postoperative high protein supplements/drinks, 
better preoperative pain control, and early tracheostomy, while others cited 
more generalized recommendations. Results: In many studies, early 
mobilization protocols reduced the rate of complications/morbidity (e.g. 
respiratory decompensation/pneumonias, deep venous thrombosis/pulmonary 
embolism, urinary tract infections, sepsis or infection), along with the 
average LOS. Conclusions: A review of multiple medical/surgical protocols 
promoting early mobilization of hospitalized patients including those 
undergoing spinal surgery reduced morbidity and LOS. Copyright: © 2014 
Epstein NE.
EMTREE DRUG INDEX TERMS
  cholesterol (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  medical procedures; mobilization; spine surgery; surgical technique; 
EMTREE MEDICAL INDEX TERMS
  anterior cervical diskectomy and fusion; article; artificial ventilation; bariatric surgery; body mass; cholesterol blood level; chronic obstructive lung disease; comorbidity; coronary artery disease; cost control; deep vein thrombosis (complication); diabetes mellitus; diet supplementation; gastrostomy; head and neck cancer (surgery); heart surgery; hospital cost; hospital readmission; human; hypertension; hypothyroidism; immobilization; length of stay; lung embolism (complication); lung resection; obesity; osteoporosis; physiotherapy; pneumonia (complication); postoperative care; postoperative complication (complication, prevention); preoperative care; priority journal; rehabilitation care; respiratory failure (therapy); scoliosis (disease management, surgery); sepsis (complication); spinal cord injury (surgery); spinal cord surgery; total hip prosthesis; total knee arthroplasty; tracheostomy; urinary tract infection (complication); 
CAS REGISTRY NUMBERS
  cholesterol (57-88-5)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Rehabilitation and Physical Medicine (19)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014578209
PUI
  L373866653
DOI
  10.4103/2152-7806.130674
FULL TEXT LINK
  http://dx.doi.org/10.4103/2152-7806.130674
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2F2152-7806.130674&atitle=A+review+article+on+the+benefits+of+early+mobilization+following+spinal+surgery+and+other+medical%2Fsurgical+procedures&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=5&issue=SUPPL.+3&spage=&epage=&aulast=Epstein&aufirst=Nancy+E.&auinit=N.E.&aufull=Epstein+N.E.&coden=&isbn=&pages=-&date=2014&auinit1=N&auinitm=E
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 423
TITLE
  Embolic brain infarction related to posttraumatic occlusion of vertebral 
artery resulting fromcervical spine injury: A case report
AUTHOR NAMES
  Nakao Y.; Terai H.
AUTHOR ADDRESSES
  (Nakao Y., nakao-ygc@umin.org; Terai H.) Department of Emergency Medicine, 
Daiyukai General Hospital, 1-9-9, Sakura, Ichinomiya, Japan.
CORRESPONDENCE ADDRESS
  Y. Nakao, Department of Emergency Medicine, Daiyukai General Hospital, 
1-9-9, Sakura, Ichinomiya, Japan. Email: nakao-ygc@umin.org
AiP/IP ENTRY DATE
  2016-09-29
FULL RECORD ENTRY DATE
  2016-10-04
SOURCE
  Journal of Medical Case Reports (2014) 8:1 Article Number: 344. Date of 
Publication: 2014
VOLUME
  8
ISSUE
  1
DATE OF PUBLICATION
  2014
ISSN
  1752-1947 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., info@biomedcentral.com
ABSTRACT
  Introduction: The frequency of vertebrobasilar ischemia in patients with 
cervical spine trauma had been regarded as low in many published papers. 
However, some case reports have described cervical spine injury associated 
with blunt vertebral artery injury. Many aspects of the management of 
vertebral artery injuries still remain controversial, including the 
screening criteria, the diagnostic modality, and the optimal treatment for 
various lesions. The case of a patient who had a brain infarction due to 
recanalization of his occluded vertebral artery following open reduction of 
cervical spinal dislocation is presented here. Case presentation: A 
41-year-old Asian man presented with C4 to C5 distractive flexion injury 
manifesting with quadriplegia and anesthesia below his C3 cord level 
(including phrenic nerve paralysis), and bowel and bladder dysfunction. 
Magnetic resonance angiography and computed tomography angiography showed 
left extracranial vertebral artery occlusion and patent contralateral 
vertebral artery. He was observed without antiplatelet and/or 
anticoagulation therapy, and underwent surgery (open reduction and internal 
fusion of C4 to C5, and tracheostomy) 8 hours after the injury. After 
surgery, supraspinal symptoms such as left horizontal nystagmus and left 
homonymous hemianopsia led to cranial computed tomography and magnetic 
resonance imaging, which showed left-side cerebellar infarction in his 
posterior inferior cerebellar artery territory and right-side posterior 
cerebral artery infarction. Magnetic resonance angiography and computed 
tomography angiography demonstrated patent bilateral vertebral artery (but 
hypoplastic right vertebral artery) and occluded right posterior cerebral 
artery. His injured vertebral artery was treated conservatively, which did 
not cause any other ischemic complications. Conclusions: The management of 
asymptomatic vertebral artery injury is controversial with several treatment 
options available, including observation alone, antiplatelet therapy, 
anticoagulation therapy, or invasive intervention. Although there are some 
reports in which management with observation alone is described as safe, we 
should pay serious attention to the vertebral artery injury caused by 
cervical spine trauma.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain embolism (complication, diagnosis, surgery); brain infarction (complication, diagnosis, surgery); cervical spine injury; vertebral artery stenosis (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial embolization; Asian; case report; cervical spinal cord injury (diagnosis); computer assisted tomography; coronary artery recanalization; deterioration; hemianopia; human; magnetic resonance angiography; male; posterior cerebral artery; priority journal; sensory dysfunction; treatment response; unconsciousness; vomiting; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  20160688124
MEDLINE PMID
  25316102 (http://www.ncbi.nlm.nih.gov/pubmed/25316102)
PUI
  L612266033
DOI
  10.1186/1752-1947-8-344
FULL TEXT LINK
  http://dx.doi.org/10.1186/1752-1947-8-344
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17521947&id=doi:10.1186%2F1752-1947-8-344&atitle=Embolic+brain+infarction+related+to+posttraumatic+occlusion+of+vertebral+artery+resulting+fromcervical+spine+injury%3A+A+case+report&stitle=J.+Med.+Case+Rep.&title=Journal+of+Medical+Case+Reports&volume=8&issue=1&spage=&epage=&aulast=Nakao&aufirst=Yaoki&auinit=Y.&aufull=Nakao+Y.&coden=&isbn=&pages=-&date=2014&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 424
TITLE
  Treatment of traumatic spondylolisthesis of the lower cervical spine with 
concomitant bilateral facet dislocations: Risk of respiratory deterioration
AUTHOR NAMES
  Ye Z.-W.; Yang S.-H.; Chen B.-J.; Xiong L.-M.; Xu J.-Z.; He Q.-Y.
AUTHOR ADDRESSES
  (Xu J.-Z.; He Q.-Y., qingyihe.hq@gmail.com) Department of Orthopedics, 
Southwest Hospital, Third Military Medical University, No. 30 Gaotanyan 
Street, Shapingba District, Chongqing 400038, China.
(Ye Z.-W.; Yang S.-H.; Chen B.-J.; Xiong L.-M.) Department of Orthopedics, 
Union Hospital of Tongji Medical College, Huazhong University of Science and 
Technology, Wuhan 430022, China.
CORRESPONDENCE ADDRESS
  Q.-Y. He, Department of Orthopedics, Southwest Hospital, Third Military 
Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 
400038, China. Email: qingyihe.hq@gmail.com
AiP/IP ENTRY DATE
  2014-06-25
FULL RECORD ENTRY DATE
  2014-06-27
SOURCE
  Clinical Neurology and Neurosurgery (2014) 123 (96-101). Date of 
Publication: August 2014
VOLUME
  123
FIRST PAGE
  96
LAST PAGE
  101
DATE OF PUBLICATION
  August 2014
ISSN
  1872-6968 (electronic)
  0303-8467
BOOK PUBLISHER
  Elsevier
ABSTRACT
  This study aimed to retrospectively examine 36 cases of bilateral cervical 
facet dislocations (BCFD) of the lower cervical spine who were at risk for 
respiratory deterioration. Methods The cases of 36 subjects with BCFD of the 
lower cervical spine who failed to achieve closed reduction were 
retrospectively studied. The extents of neurological injuries included 
posterior neck pain without neurological deficit (n = 2), incomplete spinal 
cord injury (ISCI) (n = 21), and complete spinal cord injury (CSCI) (n = 
13). Results Among the subjects, 26 (72.22%) had dyspnea, 6 required 
mechanical ventilation due to respiratory muscle paralysis, 11 required 
tracheostomy, and 9 required intubation. All patients received posterior 
approach reduction, stabilization, and fusion treatment for BCFD in one 
operative session. For the 26 quadriparetic patients with dyspnea, priority 
was given to treating their respiratory problems. For the other 10 patients 
without dyspnea, surgical treatment for irreducible lower cervical spine 
dislocation was given priority. After an average follow-up period of 63 
months, 21 complications were found, but all patients exhibited fusion. 
Twenty-one patients with ISCI exhibited improvements in their conditions of 
1 or 2 grades on the American Spinal Injury Association scale, whereas those 
with CSCI did not improve. All 26 apnea cases improved. The majority (26) of 
the 36 cases with BCFD of the lower cervical spine suffered dyspnea. 
Conclusions Although further study is required, our study suggests that the 
posterior surgical approach to the cervical spine is safe and effective for 
patients with traumatic spondylolisthesis of the lower cervical spine 
concomitant with BCFD who are at risk of respiratory deterioration. © 2014 
Elsevier B.V.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bilateral cervical facet dislocation (therapy); cervical spine dislocation (therapy); spondylolisthesis (therapy); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; clinical article; diaphragm paralysis (complication, therapy); dyspnea (complication); female; fracture reduction; human; intubation; male; neck pain; patient safety; quadriplegia; rating scale; retrospective study; risk factor; spinal cord injury (complication); spine fusion; spine stabilization; surgical approach; tracheostomy; treatment failure; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014403291
MEDLINE PMID
  25012020 (http://www.ncbi.nlm.nih.gov/pubmed/25012020)
PUI
  L373299627
DOI
  10.1016/j.clineuro.2014.04.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clineuro.2014.04.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18726968&id=doi:10.1016%2Fj.clineuro.2014.04.010&atitle=Treatment+of+traumatic+spondylolisthesis+of+the+lower+cervical+spine+with+concomitant+bilateral+facet+dislocations%3A+Risk+of+respiratory+deterioration&stitle=Clin.+Neurol.+Neurosurg.&title=Clinical+Neurology+and+Neurosurgery&volume=123&issue=&spage=96&epage=101&aulast=Xu&aufirst=Jian-Zhong&auinit=J.-Z.&aufull=Xu+J.-Z.&coden=CNNSB&isbn=&pages=96-101&date=2014&auinit1=J&auinitm=-Z
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 425
TITLE
  Attitudes to the potential development and use of units providing weaning 
from mechanical ventilation away from intensive care in the UK
AUTHOR NAMES
  Parker R.J.; Bentley A.M.
AUTHOR ADDRESSES
  (Parker R.J.) Aintree University Hospital NHS Foundation Trust, Liverpool, 
United Kingdom.
(Bentley A.M.) University Hospital of South Manchester NHS Foundation Trust, 
Manchester, United Kingdom.
CORRESPONDENCE ADDRESS
  R.J. Parker, Aintree University Hospital NHS Foundation Trust, Liverpool, 
United Kingdom.
FULL RECORD ENTRY DATE
  2015-02-09
SOURCE
  Journal of the Intensive Care Society (2014) 15:1 SUPPL. 1 (S22). Date of 
Publication: January 2014
VOLUME
  15
ISSUE
  1
FIRST PAGE
  S22
DATE OF PUBLICATION
  January 2014
CONFERENCE NAME
  State of the Art 2013 Meeting
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2013-12-16 to 2013-12-18
ISSN
  1751-1437
BOOK PUBLISHER
  Stansted News Ltd
ABSTRACT
  Long-term ventilation and weaning units (LTVWUs) are common in the USA and 
Europe. Their development was recommended in a NHS Modernisation Agency 
report in 20021 and recently by the NHS Commissioning Board.2 Despite this 
there are only a small number of units in existence in the UK. We have 
performed an internet based survey of intensive care professionals to assess 
potential need and particularly attitudes towards their development. We 
obtained 180 responses to our questionnaire, at least in part, from 97 
doctors (94 consultants), and 73 allied health professionals, working in 
both teaching and district hospitals. Prolonged mechanical ventilation (PMV) 
was a significant workload for 84.1% of respondents, 90.4% have ≥1 
patient/day fulfilling criteria for weaning delay and 76.8% ≥1 patient/day 
meeting criteria for weaning failure. A majority of respondents (70.8%) felt 
this impacts on providing acute care and 82.1% feel this workload will 
increase in future. LTVWUs for spinal injury patients are available to 54.1% 
of respondents compared with 40% of non-spinal injured patients (p<0.05). 
Only 16.1% said their hospital was capable of managing tracheostomy 
ventilated patients in a facility outside intensive care, most commonly in 
teaching hospitals (p<0.05). For those without access 93% would consider 
referring patients requiring PMV for ongoing care to a LTVWU. Benefits of 
LTVWU were felt to be, increasing the availability of acute ICU beds (92.6%) 
and focusing rehabilitation resources (85.8%). Most common barriers to 
referral were concerns about safety of patients away from ICU (51.9%), a 
lack of proven benefit (48.3%) and an unwillingness to refer until patient 
felt to be truly ventilator dependent and community placement needed 
(43.2%). Respondents believe future LTVWUs should be regionally based 
(84.6%), linked to local critical care networks (76.6%), and led by 
multidisciplinary teams (56.4%). 24.4% of respondents felt the clinical lead 
should be a intensive care physician. Respondents in teaching hospitals had 
access to more ICU beds, but were significantly more likely to identify 
patients with weaning delay and failure. They perceived a bigger future 
problem compared with district hospitals, 95.7% vs 78.2% respectively 
(p<0.05). In conclusion, this survey supports the view that patients 
requiring PMV are perceived as a significant workload and impact on the 
availability of acute ICU beds. LTVWUs are a potential but currently limited 
resource. We would recommend that if LTVWUs are to grow and ultimately be 
successful intensive care practitioners actively engage in the commissioning 
process for their development, their clinical leadership, they are linked to 
intensive care operational delivery networks and adhere to the same 
standards of care.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; intensive care; United Kingdom; weaning; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; community; consultation; emergency care; Europe; health practitioner; hospital; human; intensivist; Internet; leadership; patient; physician; public hospital; questionnaire; rehabilitation; safety; spine injury; teaching; teaching hospital; tracheostomy; ventilated patient; ventilator; workload; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71773090
DOI
  10.1177/17511437140151S105
FULL TEXT LINK
  http://dx.doi.org/10.1177/17511437140151S105
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17511437&id=doi:10.1177%2F17511437140151S105&atitle=Attitudes+to+the+potential+development+and+use+of+units+providing+weaning+from+mechanical+ventilation+away+from+intensive+care+in+the+UK&stitle=J.+Intensive+Care+Soc.&title=Journal+of+the+Intensive+Care+Society&volume=15&issue=1&spage=S22&epage=&aulast=Parker&aufirst=R.J.&auinit=R.J.&aufull=Parker+R.J.&coden=&isbn=&pages=S22-&date=2014&auinit1=R&auinitm=J
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 426
TITLE
  Reliability of the spine adverse events severity system (SAVES) for 
individuals with traumatic spinal cord injury
AUTHOR NAMES
  Glennie R.A.; Noonan V.K.; Fallah N.; Park S.E.; Thorogood N.P.; Cheung A.; Fisher C.G.; Dvorak M.F.; Street J.T.
AUTHOR ADDRESSES
  (Glennie R.A.; Noonan V.K.; Fallah N.; Park S.E.; Fisher C.G.; Dvorak M.F.; 
Street J.T., John.Street@vch.ca) Division of Spine, Department of 
Orthopedics, University of British Columbia, 818 West 10th Avenue, 
Vancouver, Canada.
(Noonan V.K.; Fallah N.; Park S.E.; Thorogood N.P.; Cheung A.; Dvorak M.F.) 
Rick Hansen Institute, Vancouver, Canada.
CORRESPONDENCE ADDRESS
  J.T. Street, Division of Spine, Department of Orthopedics, University of 
British Columbia, 818 West 10th Avenue, Vancouver, Canada.
AiP/IP ENTRY DATE
  2014-07-18
FULL RECORD ENTRY DATE
  2014-11-06
SOURCE
  Spinal Cord (2014) 52:10 (758-763). Date of Publication: 25 Oct 2014
VOLUME
  52
ISSUE
  10
FIRST PAGE
  758
LAST PAGE
  763
DATE OF PUBLICATION
  25 Oct 2014
ISSN
  1476-5624 (electronic)
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design:Test-retest analysis.Objectives:To determine the intra- and 
inter-rater reliability of the Spine Adverse Events Severity System for 
Spinal Cord Injury (SAVES-SCI) in patients with traumatic 
SCI.Setting:Quaternary care spine program in Vancouver, Canada.Methods:Ten 
hypothetical patient cases were developed. The cases were completed by 10 
raters (seven physicians, one nurse, one physiotherapist and one researcher) 
who were asked to identify and grade the severity of adverse events using 
SAVES-SCI twice with 1-week interval. Intra- and inter-rater reliability 
were calculated using kappa statistics and intraclass correlation 
coefficients (ICC).Results:Intra-rater reliability for both identifying and 
grading AEs were high with all AEs (kappa greater than 0.6) except for bone 
implant, diathermy burn, massive blood loss, myocardial infarction, 
neurological deterioration, pressure ulcer, return to operating room and 
tracheostomy requirment. The inter-rater reliability measured with ICC were 
all above 0.6 for identifying and grading intraoperative, pre and 
postoperative AEs and consequences of SCI.Conclusions:The SAVES-SCI 
demonstrated acceptable intra-and inter-rater reliability for a majority of 
the AEs. Further clarification and definition of some of the AEs as well as 
provision of sample training cases for clincians would assist in reducing 
measurement errors. The SAVES-SCI is a useful tool to assess and capture AEs 
in patients with acute traumatic SCI.Sponsorship:Funded by Rick Hansen 
Institute and Health Canada.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  assessment of humans; interrater reliability; intrarater reliability; spinal cord injury; spine adverse events severity system; 
EMTREE MEDICAL INDEX TERMS
  article; Canada; correlation coefficient; human; kappa statistics; nurse; peroperative complication; physician; physiotherapist; postoperative complication; preoperative complication; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014735139
MEDLINE PMID
  25023862 (http://www.ncbi.nlm.nih.gov/pubmed/25023862)
PUI
  L53241619
DOI
  10.1038/sc.2014.116
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2014.116
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765624&id=doi:10.1038%2Fsc.2014.116&atitle=Reliability+of+the+spine+adverse+events+severity+system+%28SAVES%29+for+individuals+with+traumatic+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=52&issue=10&spage=758&epage=763&aulast=Glennie&aufirst=R.A.&auinit=R.A.&aufull=Glennie+R.A.&coden=SPCOF&isbn=&pages=758-763&date=2014&auinit1=R&auinitm=A
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 427
TITLE
  Repair of retrograde ascending dissection after descending stent grafting
AUTHOR NAMES
  Idrees J.; Arafat A.; Johnston D.R.; Svensson L.G.; Roselli E.E.
AUTHOR ADDRESSES
  (Idrees J.; Arafat A.; Johnston D.R.; Svensson L.G.; Roselli E.E., 
roselle@ccf.org) Department of Thoracic and Cardiovascular Surgery, 
Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195-5108, United States.
CORRESPONDENCE ADDRESS
  E.E. Roselli, Department of Thoracic and Cardiovascular Surgery, Cleveland 
Clinic, 9500 Euclid Ave, Cleveland, OH 44195-5108, United States. Email: 
roselle@ccf.org
AiP/IP ENTRY DATE
  2013-10-24
FULL RECORD ENTRY DATE
  2013-12-31
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2014) 147:1 (151-154). Date 
of Publication: January 2014
VOLUME
  147
ISSUE
  1
FIRST PAGE
  151
LAST PAGE
  154
DATE OF PUBLICATION
  January 2014
ISSN
  0022-5223
  1097-685X (electronic)
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  Objective: Retrograde dissection is now recognized as an important 
complication after thoracic endovascular aortic repair (TEVAR), but its 
treatment is poorly understood. Our objectives were to investigate the 
risks, describe the repair methods, and assess the outcomes of this 
complication. Methods: From 2000 to 2012, 766 patients underwent TEVAR. Of 
these patients, 14 (1.8%), plus 1 who had undergone TEVAR elsewhere (n = 
15), developed retrograde dissection after stent grafting. They had 
undergone TEVAR for distal aortic dissection in 7, intramural hematoma in 5, 
aneurysm in 2, and transection in 1. Their mean age was 65 ± 9 years. At the 
initial TEVAR, the left subclavian artery was covered in 9, the mean stent 
graft diameter was 34 ± 2 mm, and >1 device was used in 8 patients. The site 
of entry tear was at the greater curvature in 11 and lesser curvature in 4. 
One patient ruptured and died 12 days after TEVAR and never made it to the 
operating room. The other 14 underwent proximal aortic repair. The median 
interval between TEVAR and repair of retrograde dissection was 6 months; 3 
patients presented within 1 month. The repair techniques included reverse 
frozen elephant trunk in 5, total arch repair in 4, ascending or hemiarch 
repair in 4, and ascending TEVAR in 1. Concomitant procedures included 
aortic valve repair in 4, replacement in 2, root remodeling in 1, and 
coronary bypass in 1. Results: No operative mortality occurred. One patient 
underwent reoperation for bleeding. Two required a tracheostomy for 
respiratory failure. However, no renal failure, stroke, or spinal injury 
occurred. At a median follow-up of 26 months, 4 aortic reoperations had 
occurred: 1 distal stent graft extension for type 1b endoleak, 2 hybrid 
thoracoabdominal completion repairs for growth of residual distal disease, 
and 1 emergency TEVAR for aortobronchial fistula. The latter patient died of 
septic complications, and 3 other late noncardiac deaths occurred. 
Conclusions: Retrograde ascending dissection can present as an early or a 
late complication after descending stent grafting because of aortic 
instability or disease progression and has usually been associated with 
descending dissection or intramural hematoma. It is a life-threatening 
complication that can be managed safely with early recognition and rapid 
delivery of open or hybrid repair. Copyright © 2014 by The American 
Association for Thoracic Surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic aneurysm endovascular graft; aortic dissection (complication, surgery); endovascular aneurysm repair; retrograde ascending dissection (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; aortic aneurysm (surgery); aortic arch surgery; aortic reconstruction; aortic root surgery; aortic valve repair; aortic valve replacement; bleeding (surgery); cardiovascular risk; conference paper; coronary artery bypass graft; descending aortic surgery; endoleak (complication); follow up; hematoma (surgery); human; major clinical study; operating room; postoperative infection (complication); priority journal; reoperation; respiratory failure (surgery); reverse frozen elephant trunk; subclavian artery; surgical mortality; tracheostomy; 
DEVICE TRADE NAMES
  Gore-Tex  , United StatesGore

  zenith  , United StatesCook

DEVICE MANUFACTURERS
   (United States)Cook
   (United States)Gore
   (United States)Medtronic
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013801125
MEDLINE PMID
  24139893 (http://www.ncbi.nlm.nih.gov/pubmed/24139893)
PUI
  L52821360
DOI
  10.1016/j.jtcvs.2013.08.075
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2013.08.075
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225223&id=doi:10.1016%2Fj.jtcvs.2013.08.075&atitle=Repair+of+retrograde+ascending+dissection+after+descending+stent+grafting&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=147&issue=1&spage=151&epage=154&aulast=Idrees&aufirst=Jahanzaib&auinit=J.&aufull=Idrees+J.&coden=JTCSA&isbn=&pages=151-154&date=2014&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 428
TITLE
  Postoperative spine and VEPTR infections in children: A case-control study
AUTHOR NAMES
  Farley F.A.; Li Y.; Gilsdorf J.R.; VanderHave K.L.; Hensinger R.N.; Speers M.; Childers D.; Caird M.S.
AUTHOR ADDRESSES
  (Farley F.A., fafarley@med.umich.edu; Li Y.; VanderHave K.L.; Hensinger 
R.N.; Speers M.; Caird M.S.) Department of Orthopaedic Surgery, University 
of Michigan, Mott Children's Hospital, SPC 4241, 1540 East Hospital Drive, 
Ann Arbor, MI 48109, United States.
(Gilsdorf J.R.) Department of Pediatrics, United States.
(Childers D.) Department of Statistics, University of Michigan, Ann Arbor, 
MI, United States.
CORRESPONDENCE ADDRESS
  F.A. Farley, Department of Orthopaedic Surgery, University of Michigan, Mott 
Children's Hospital, SPC 4241, 1540 East Hospital Drive, Ann Arbor, MI 
48109, United States. Email: fafarley@med.umich.edu
AiP/IP ENTRY DATE
  2013-12-26
FULL RECORD ENTRY DATE
  2013-12-31
SOURCE
  Journal of Pediatric Orthopaedics (2014) 34:1 (14-21). Date of Publication: 
January 2014
VOLUME
  34
ISSUE
  1
FIRST PAGE
  14
LAST PAGE
  21
DATE OF PUBLICATION
  January 2014
ISSN
  0271-6798
  1539-2570 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Background: Surgical site infection (SSI) after pediatric scoliosis surgery 
is a major cause of morbidity. We compared the odds ratios of various 
potential risk factors for infection among patients who developed a deep SSI 
following spinal deformity surgery and those who remained infection free. 
Methods: This was a case-control study, not a matched study. More 
noninfection cases (50) than infection cases (20) were selected because more 
were available. Twenty children with a deep SSI after scoliosis surgery were 
compared with 50 similar children who did not develop a deep SSI. Fourteen 
perioperative factors were examined in both the groups. Results: Of the 20 
patients who had a deep SSI, 14 had neuromuscular scoliosis. In the infected 
group, 6 patients had undergone vertical expandable prosthetic titanium rib 
placement, 2 had undergone growing rod insertion, and 12 had undergone 
posterior spinal fusion. Eighteen patients developed a SSI within 1 year of 
the operation and 2 patients presented with a SSI >1 year after surgery. 
Sixteen patients had positive cultures. Majority were skin flora: 
coagulase-negative Staphylococcus (8) and Propionibacterium acnes (4). Both 
patients with tracheostomies had Enterococcus faecalis infections. When 
comparing the 20 patients with deep SSI to the 50 controls, increased 
preoperative Cobb angle (P=0.011), increased postoperative Cobb angle 
(P=0.0043), nonambulatory status (P=0.0002), and increased length of stay 
(P=0.015) were associated with significantly increased odds of infection. 
Conclusions: Our study shows that patients with neuromuscular scoliosis are 
at higher risk of developing a deep SSI after spinal deformity surgery. Skin 
flora is a common cause of deep SSI. We have now instituted a standard skin 
preparation protocol to include alcohol and chlorhexidine washes the night 
before and the morning of surgery. We have altered our prophylactic 
antibiotic regimen to cover skin flora in all patients and gastrointestinal 
flora in patients with a tracheostomy. We have counseled the families of 
nonambulatory children with large neuromuscular curves regarding the 
significantly increased odds of postoperative deep SSI. Level of evidence: 
Level III. Copyright © 2013 by Lippincott Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  alcohol; chlorhexidine; titanium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone prosthesis; spine; spine surgery; surgical infection (complication); vertical expandable prosthetic titanium rib; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; case control study; child; clinical article; coagulase negative Staphylococcus; controlled study; Enterococcus faecalis; female; human; infection rate; infection risk; length of stay; male; preschool child; priority journal; Propionibacterium acnes; school child; scoliosis (surgery); skin flora; spine fusion; spine malformation; tracheostomy; 
CAS REGISTRY NUMBERS
  alcohol (64-17-5)
  chlorhexidine (3697-42-5, 55-56-1)
  titanium (7440-32-6)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013798526
MEDLINE PMID
  24327165 (http://www.ncbi.nlm.nih.gov/pubmed/24327165)
PUI
  L370496636
DOI
  10.1097/BPO.0b013e3182a0064d
FULL TEXT LINK
  http://dx.doi.org/10.1097/BPO.0b013e3182a0064d
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02716798&id=doi:10.1097%2FBPO.0b013e3182a0064d&atitle=Postoperative+spine+and+VEPTR+infections+in+children%3A+A+case-control+study&stitle=J.+Pediatr.+Orthop.&title=Journal+of+Pediatric+Orthopaedics&volume=34&issue=1&spage=14&epage=21&aulast=Farley&aufirst=Frances+A.&auinit=F.A.&aufull=Farley+F.A.&coden=JPORD&isbn=&pages=14-21&date=2014&auinit1=F&auinitm=A
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 429
TITLE
  Anesthesia management of a patient with lumbar spinal stenosis and tracheal 
stenting
AUTHOR NAMES
  Canpolat D.G.; Çelik U.; Aydin A.; Biçer C.; Madenoǧlu H.
AUTHOR ADDRESSES
  (Canpolat D.G., dgcanpolat@gmail.com; Çelik U.; Aydin A.; Biçer C.; 
Madenoǧlu H.) Department of Anaesthesiology and Reanimation, Kayseri, 
Turkey.
CORRESPONDENCE ADDRESS
  D. G. Canpolat, Department of Anaesthesiology and Reanimation, Kayseri, 
Turkey. Email: dgcanpolat@gmail.com
AiP/IP ENTRY DATE
  2014-08-01
FULL RECORD ENTRY DATE
  2014-08-11
SOURCE
  Erciyes Tip Dergisi (2014) 36:2 (94-96). Date of Publication: June 2014
VOLUME
  36
ISSUE
  2
FIRST PAGE
  94
LAST PAGE
  96
DATE OF PUBLICATION
  June 2014
ISSN
  1300-199X
BOOK PUBLISHER
  AVES Ibrahim Kara, 105/9 Buyukdere Cad, Mecidiyekoy,Sisli, Istanbul, Turkey. 
info@avesyayincilik.com
ABSTRACT
  Tracheal stenosis may occur after congenital problems and long-term 
endotracheal tube compression. Spinal stenosis is one of the 3 most common 
reasons in patients undergoing surgery due to low back and leg pain. Both 
general and regional anesthesia are used for lumbar surgery. A 56-year-old 
woman was admitted to our hospital with low back pain and leg paresthesia. A 
permanent tracheal stent was placed 11 years ago due to tracheal stenosis 
developed after tracheostomy performed for anaphylaxis and respiratory 
depression. Herein, a case of regional anesthesia technique applied during 
spinal stenosis surgery is presented. © 2014 by Erciyes University School of 
Medicine.
EMTREE DRUG INDEX TERMS
  bupivacaine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lumbar spinal stenosis (surgery); spinal anesthesia; tracheobronchial stent; 
EMTREE MEDICAL INDEX TERMS
  adult; article; body position; case report; computer assisted tomography; discectomy; endotracheal tube; female; forced expiratory volume; forced vital capacity; human; intensive care unit; laminectomy; leg pain; low back pain; lumbar disk hernia; lung function test; metal stent; middle aged; nuclear magnetic resonance imaging; oxygen saturation; paresthesia; regional anesthesia; respiration depression; spinal cord decompression; spinal needle; trachea stenosis; tracheostomy; 
DRUG TRADE NAMES
  marcaine  , TurkeyAstra Zeneca

DRUG MANUFACTURERS
   (Turkey)Astra Zeneca
DEVICE TRADE NAMES
  22G Quincke
CAS REGISTRY NUMBERS
  bupivacaine (18010-40-7, 2180-92-9, 55750-21-5, 38396-39-3)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014497288
PUI
  L373609545
DOI
  10.5152/etd.2013.57
FULL TEXT LINK
  http://dx.doi.org/10.5152/etd.2013.57
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1300199X&id=doi:10.5152%2Fetd.2013.57&atitle=Anesthesia+management+of+a+patient+with+lumbar+spinal+stenosis+and+tracheal+stenting&stitle=Erciyes+Tip+Derg.&title=Erciyes+Tip+Dergisi&volume=36&issue=2&spage=94&epage=96&aulast=Canpolat&aufirst=Dilek+G%C3%BCnay&auinit=D.G.&aufull=Canpolat+D.G.&coden=EDERF&isbn=&pages=94-96&date=2014&auinit1=D&auinitm=G
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 430
TITLE
  Surgical strategies and outcomes of spinal ependymomas of different lengths: 
Analysis of 210 patients: Clinical article
AUTHOR NAMES
  Li T.-Y.; Chu J.-S.; Xu Y.-L.; Yang J.; Wang J.; Huang Y.-H.; Kwan A.-L.; Wang G.-H.
AUTHOR ADDRESSES
  (Li T.-Y.; Chu J.-S.; Xu Y.-L.; Yang J.; Wang G.-H., wghwynsby@yahoo.com) 
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical 
University, Tiantan Xili 6, Chongwen District, Beijing 100050, China.
(Wang J.) Department of Neurosurgery, Providence Hospital, Seattle, WA, 
United States.
(Huang Y.-H.) Department of Neurosurgery, Kaohsiung Chang Gung Memorial 
Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
(Kwan A.-L.) Department of Surgery, College of Medicine, Kaohsiung Medical 
University, Kaohsiung, Taiwan.
(Kwan A.-L.) Department of Neurosurgery, Kaohsiung Medical University 
Hospital, Kaohsiung, Taiwan.
(Kwan A.-L.) Department of Neurosurgery, University of Virginia, 
Charlottesville, VA, United States.
(Wang G.-H., wghwynsby@yahoo.com) Beijing Neurosurgical Institute, Capital 
Medical University, Beijing, China.
(Li T.-Y.) Department of Neurosurgery, Beijing Dongzhimen Hospital Eastern, 
Beijing University of Chinese Medicine, Beijing, China.
CORRESPONDENCE ADDRESS
  G.-H. Wang, Department of Neurosurgery, Beijing Tiantan Hospital, Capital 
Medical University, Tiantan Xili 6, Chongwen District, Beijing 100050, 
China. Email: wghwynsby@yahoo.com
AiP/IP ENTRY DATE
  2014-08-14
FULL RECORD ENTRY DATE
  2014-08-22
SOURCE
  Journal of Neurosurgery: Spine (2014) 21:2 (249-259). Date of Publication: 
August 2014
VOLUME
  21
ISSUE
  2
FIRST PAGE
  249
LAST PAGE
  259
DATE OF PUBLICATION
  August 2014
ISSN
  1547-5646 (electronic)
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons, jnevro@virginia.edu
ABSTRACT
  Object. The aim of this study was to investigate the surgical strategies and 
outcomes for spinal ependymomas of different lengths. Methods. The authors 
used data from 210 patients with spinal ependymomas (WHO Grades II and III) 
in this 10-year retrospective study (January 1999 to December 2008), 
dividing them into 3 different groups according to length (spinal 
ependymomas < 5 cm, 5-10 cm, and > 10 cm). All patients underwent tumor 
resection. The basic characteristics of the patients were reviewed and the 
functional status was assessed using the McCormick classification. Results. 
There were 89, 81, and 40 patients, respectively, in the 3 groups (< 5 cm, 
5-10 cm, and > 10 cm). Gross-total resections (GTRs) were performed in 172 
patients (81.9% overall, or 86.5%, 79.0%, and 77.5% in the 3 groups, 
respectively). Subtotal and partial resections were achieved in 38 patients 
(18.1%). Eight patients with medulla oblongata or upper cervical cord tumors 
received a tracheotomy postoperatively. The follow-up period ranged from 56 
to 176 months. One hundred thirty-five patients (76.7%) experienced 
improvement, (88.2%, 83.8%, and 34.4% in the < 5 cm, 5-10 cm, and > 10 cm 
groups, respectively). Thirty-three patients (18.8%) maintained their 
pretreatment status, and 8 patients (4.5%) showed deterioration following 
tumor resection at 6 months. Tumor recurrence or progression was observed in 
6 (2.9%) of the 210 patients. Among the 6 patients, recurrent tumors were 
located in the conus (n = 3), thoracic (n = 1), and medullocervical cord (n 
= 2). Conclusions. Radical resection of spinal ependymomas could be 
performed in most patients, and the rate of GTR was significantly different 
in the different-length groups (< 10 cm vs > 10 cm, p = 0.032). Patients 
with longer tumors had worse surgical results compared with those with small 
tumors (p < 0.001), and more postoperative neuropathic pain and 
proprioceptive deficits could usually be observed in patients harboring 
larger tumors. Early diagnosis and timely operation are critical to 
achieving better neurological outcomes. For tumors with dense adhesions, 
complete removal should be performed cautiously because of the significant 
incidence of neurological deterioration. ©AANS, 2014.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ependymoma (surgery); spinal ependymoma (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; bladder dysfunction; cancer prognosis; cancer surgery; cervical spinal cord; child; conus medullaris; deterioration; female; follow up; functional status; human; major clinical study; male; medulla oblongata; motor evoked potential; neuropathic pain; nuclear magnetic resonance imaging; pain; paresthesia; postoperative care; proprioception; radical resection; retrospective study; somatosensory evoked potential; surgical technique; tracheotomy; tumor bleeding; tumor recurrence; 
EMBASE CLASSIFICATIONS
  Cancer (16)
  Public Health, Social Medicine and Epidemiology (17)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014524128
MEDLINE PMID
  24836662 (http://www.ncbi.nlm.nih.gov/pubmed/24836662)
PUI
  L373697537
DOI
  10.3171/2014.3.SPINE13481
FULL TEXT LINK
  http://dx.doi.org/10.3171/2014.3.SPINE13481
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475646&id=doi:10.3171%2F2014.3.SPINE13481&atitle=Surgical+strategies+and+outcomes+of+spinal+ependymomas+of+different+lengths%3A+Analysis+of+210+patients%3A+Clinical+article&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=21&issue=2&spage=249&epage=259&aulast=Li&aufirst=Teng-Yu&auinit=T.-Y.&aufull=Li+T.-Y.&coden=&isbn=&pages=249-259&date=2014&auinit1=T&auinitm=-Y
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 431
TITLE
  A 24-year-old with spinal cord injury and an unusual polysomnogram
AUTHOR NAMES
  Khosa S.; Ali M.E.; Krishnan V.
AUTHOR ADDRESSES
  (Khosa S.; Krishnan V., rishnan@metrohealth.org) Department of Pulmonary, 
Critical Care, and Sleep Medicine, MetroHealth Medical Center, 2500 
MetroHealth Drive, Bell Greve, Cleveland, United States.
(Ali M.E.) Department of Pulmonary, Critical Care, and Sleep Medicine, Case 
Western Reserve University, Cleveland, United States.
CORRESPONDENCE ADDRESS
  V. Krishnan, Department of Pulmonary, Critical Care, and Sleep Medicine, 
MetroHealth Medical Center, 2500 MetroHealth Drive, Bell Greve, Cleveland, 
United States.
AiP/IP ENTRY DATE
  2014-12-02
FULL RECORD ENTRY DATE
  2014-12-11
SOURCE
  Annals of the American Thoracic Society (2014) 11:7 (1159-1161). Date of 
Publication: 1 Sep 2014
VOLUME
  11
ISSUE
  7
FIRST PAGE
  1159
LAST PAGE
  1161
DATE OF PUBLICATION
  1 Sep 2014
ISSN
  2325-6621
BOOK PUBLISHER
  American Thoracic Society, malexander@thoracic.org
ABSTRACT
  One of the challenges in interpreting sleep studies is determining whether 
findings are real or artifacts of electromechanical phenomena. The artifact 
seen on this study was consistent with the patient's history, but was an 
unusual finding for typical patients undergoing sleep studies. The findings 
are reviewed in the context of the clinical presentation of the case 
patient.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  polysomnography; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; airway obstruction; article; artificial ventilation; bronchoscopy; case report; electrostimulation; follow up; human; hypoventilation; male; muscle stimulator; signal transduction; sleep disordered breathing; tracheostomy; young adult; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014926118
MEDLINE PMID
  25237997 (http://www.ncbi.nlm.nih.gov/pubmed/25237997)
PUI
  L600573000
DOI
  10.1513/AnnalsATS.201401-018CC
FULL TEXT LINK
  http://dx.doi.org/10.1513/AnnalsATS.201401-018CC
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23256621&id=doi:10.1513%2FAnnalsATS.201401-018CC&atitle=A+24-year-old+with+spinal+cord+injury+and+an+unusual+polysomnogram&stitle=Ann.+Am.+Thorac.+Soc.&title=Annals+of+the+American+Thoracic+Society&volume=11&issue=7&spage=1159&epage=1161&aulast=Khosa&aufirst=Sandeep&auinit=S.&aufull=Khosa+S.&coden=&isbn=&pages=1159-1161&date=2014&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 432
TITLE
  Three-column osteotomies of the lower cervical and upper thoracic spine: 
comparison of early outcomes, radiographic parameters, and peri-operative 
complications in 48 patients
AUTHOR NAMES
  Theologis A.A.; Tabaraee E.; Funao H.; Smith J.S.; Burch S.; Tay B.; Kebaish K.; Deviren V.; Ames C.
AUTHOR ADDRESSES
  (Theologis A.A., Alekos.Theologis@ucsf.edu; Tabaraee E.; Burch S.; Tay B.; 
Deviren V.) Department of Orthopaedic Surgery, University of California at 
San Francisco (UCSF), San Francisco, United States.
(Funao H.; Kebaish K.) Department of Orthopaedic Surgery, The Johns Hopkins 
Hospital, Baltimore, United States.
(Smith J.S.) Department of Neurologic Surgery, University of Virginia, 
Charlottesville, United States.
(Ames C.) Department of Neurologic Surgery, UCSF, San Francisco, United 
States.
CORRESPONDENCE ADDRESS
  A.A. Theologis, Department of Orthopaedic Surgery, University of California 
at San Francisco (UCSF), San Francisco, United States.
AiP/IP ENTRY DATE
  2014-12-09
FULL RECORD ENTRY DATE
  2015-08-20
SOURCE
  European Spine Journal (2014) 24:1 (23-30). Date of Publication: 2014
VOLUME
  24
ISSUE
  1
FIRST PAGE
  23
LAST PAGE
  30
DATE OF PUBLICATION
  2014
ISSN
  1432-0932 (electronic)
  0940-6719
BOOK PUBLISHER
  Springer Verlag, service@springer.de
ABSTRACT
  Purpose: To evaluate and compare early radiographic and clinical outcomes of 
lower cervical and upper thoracic three-column osteotomies (3CO) for 
cervicothoracic kyphosis correction.Methods: Patients who underwent 3CO at 
the cervicothoracic junction at two institutions were retrospectively 
reviewed. Patients were divided into two groups: lower cervical osteotomy 
(LCO) and upper thoracic osteotomy (UTO: T1–T5). Operative data, 
radiographic alignment, peri-operative complications, and clinical outcomes 
were compared between the groups.Results: Forty-eight patients [male: 24; 
female: 24; average age 61 years (range 18–92 years); mean follow-up: 
22 months] met inclusion criteria. A total of 24 pedicle subtraction 
osteotomies and 24 vertebral column resections were performed. Compared to 
UTO, LCO operative time was significantly shorter, average ICU and hospital 
stays were significantly longer, and the average pre-operative cervical 
sagittal vertical axis (SVA) and kyphosis were significantly greater 
(p < 0.05). For both groups, there was significant improvement in cervical 
SVA, cervical lordosis, segmental angle, Neck Disability Index (NDI), SRS 
Activity, and pain visual analog score (p < 0.05). Reoperation rates were 
similar between the groups (LCO: 33.3 %; UTO: 18 %, p = 0.28). 
Significantly, more patients required tracheostomy/gastrostomy tubes after 
LCO (3 vs. 0 in the UTO group, p = 0.03).Conclusions: Three-column posterior 
osteotomies at the cervicothoracic junction restored regional sagittal 
alignment and improved quality of life in this series of patients with rigid 
cervicothoracic deformity, albeit with high complication rates. Lower 
cervical osteotomies provided greater cervical SVA correction and were 
shorter operations, although they were associated with more complications 
and longer hospital and ICU stays compared to upper thoracic osteotomies.
EMTREE DRUG INDEX TERMS
  antibiotic agent (intravenous drug administration, oral drug administration, 
parenteral drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervicothoracic kyphosis (surgery); kyphosis (surgery); lower cervical osteotomy; osteotomy; peroperative complication (complication); radiological parameters; three column osteotomy; upper thoracic osteotomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cerebral palsy; cervical lordosis; cervical plate; cervical sagittal vertical axis; cervical spine; clinical article; controlled study; debridement; deep vein thrombosis (complication); diffuse idiopathic skeletal hyperostosis; dysphagia (complication); female; follow up; hospitalization; human; hyperostosis; intensive care unit; intermethod comparison; laminectomy; lordosis; male; metastatic breast cancer; methicillin resistant Staphylococcus aureus infection (complication); musculoskeletal system parameters; Neck Disability Index; neck pain; neurofibromatosis type 1; nutritional support; operation duration; outcome assessment; pathologic fracture; pedicle subtraction osteotomy; percutaneous endoscopic gastrostomy; pneumonia (complication); pneumothorax (complication); postoperative period; priority journal; pseudarthrosis (complication); radiculopathy (complication); reoperation; retrospective study; segmental angle; spine surgery; stomach tube; surgical infection (complication); thoracic spine; tracheostomy; tracheostomy tube; vertebral column resection; very elderly; visual analog scale; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014941783
MEDLINE PMID
  25394862 (http://www.ncbi.nlm.nih.gov/pubmed/25394862)
PUI
  L600642404
DOI
  10.1007/s00586-014-3655-6
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-014-3655-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-014-3655-6&atitle=Three-column+osteotomies+of+the+lower+cervical+and+upper+thoracic+spine%3A+comparison+of+early+outcomes%2C+radiographic+parameters%2C+and+peri-operative+complications+in+48+patients&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=24&issue=1&spage=23&epage=30&aulast=Theologis&aufirst=Alexander+A.&auinit=A.A.&aufull=Theologis+A.A.&coden=ESJOE&isbn=&pages=23-30&date=2014&auinit1=A&auinitm=A
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 433
TITLE
  Tracheostomy: Epidemiology, indications, timing, technique, and outcomes
AUTHOR NAMES
  Cheung N.H.; Napolitano L.M.
AUTHOR ADDRESSES
  (Cheung N.H.; Napolitano L.M., lenan@umich.edu) Division of Acute Care 
Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, 
United States.
CORRESPONDENCE ADDRESS
  L. M. Napolitano, Department of Surgery, University of Michigan Health 
System, University Hospital, 1500 East Medical Drive, Ann Arbor, MI 
48109-0033, United States. Email: lenan@umich.edu
AiP/IP ENTRY DATE
  2014-06-23
FULL RECORD ENTRY DATE
  2014-07-01
SOURCE
  Respiratory Care (2014) 59:6 (895-919). Date of Publication: 2014
  52nd Conference on Adult Artificial Airways and Airway Adjuncts, Book Series 
Title:
VOLUME
  59
ISSUE
  6
FIRST PAGE
  895
LAST PAGE
  919
DATE OF PUBLICATION
  2014
CONFERENCE NAME
  52nd Conference on Adult Artificial Airways and Airway Adjuncts
CONFERENCE LOCATION
  St. Petersburg, FL, United States
CONFERENCE DATE
  2013-06-14 to 2013-06-15
ISSN
  1943-3654 (electronic)
  0020-1324
BOOK PUBLISHER
  American Association for Respiratory Care
ABSTRACT
  Tracheostomy is a common procedure performed in critically ill patients 
requiring prolonged mechanical ventilation for acute respiratory failure and 
for airway issues. The ideal timing (early vs late) and techniques 
(percutaneous dilatational, other new percutaneous techniques, open 
surgical) for tracheostomy have been topics of considerable debate. In this 
review, we address general issues regarding tracheostomy (epidemiology, 
indications, and outcomes) and specifically review the literature regarding 
appropriate timing of tracheostomy tube placement. Based on evidence from 2 
recent large randomized trials, it is reasonable to wait at least 10 d to be 
certain that a patient has an ongoing need for mechanical ventilation before 
consideration of tracheostomy. Percutaneous tracheostomy with flexible 
bronchoscopy guidance is recommended, and optimal percutaneous techniques, 
indications, and contraindications and results in high-risk patients 
(coagulopathy, thrombocytopenia, obesity) are reviewed. Additional issues 
related to tracheostomy diagnosis-related groups, charges, and procedural 
costs are reviewed. New advances regarding tracheostomy include the use of 
real-time ultrasound guidance for percutaneous tracheostomy in high-risk 
patients. New tracheostomy tubes (tapered with low-profile cuffs that fit 
better on the tapered dilators, longer percutaneous tracheostomy tubes) are 
discussed for optimal use with percutaneous dilatational tracheostomy. Two 
new percutaneous techniques, a balloon inflation technique (Dolphin) and the 
PercuTwist procedure, are reviewed. The efficacy of tracheostomy teams and 
tracheostomy hospital services with standardized protocols for tracheostomy 
insertion and care has been associated with improved outcomes. Finally, the 
UK National Tracheostomy Safety Project developed standardized resources for 
education of both health care providers and patients, including emergency 
algorithms for tracheostomy incidents, and serves as an excellent 
educational resource in this important area. © 2014 Daedalus Enterprises.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory tract disease (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; bronchoscopy; chronic obstructive lung disease; clinical assessment; conference paper; hospitalization; human; injury; operation duration; patient satisfaction; postoperative complication; risk assessment; spinal cord injury; surgical technique; traumatic brain injury; treatment indication; treatment outcome; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014401544
MEDLINE PMID
  24891198 (http://www.ncbi.nlm.nih.gov/pubmed/24891198)
PUI
  L373293034
DOI
  10.4187/respcare.02971
FULL TEXT LINK
  http://dx.doi.org/10.4187/respcare.02971
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19433654&id=doi:10.4187%2Frespcare.02971&atitle=Tracheostomy%3A+Epidemiology%2C+indications%2C+timing%2C+technique%2C+and+outcomes&stitle=Respir.+Care&title=Respiratory+Care&volume=59&issue=6&spage=895&epage=919&aulast=Cheung&aufirst=Nora+H.&auinit=N.H.&aufull=Cheung+N.H.&coden=RECAC&isbn=&pages=895-919&date=2014&auinit1=N&auinitm=H
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 434
TITLE
  Endoscopic transnasal surgery as a replacement for maxillotomy techniques to 
approach the central skull base: Fewer complications and more acceptable to 
patients?
AUTHOR NAMES
  Choi D.; Subramanian A.; Elwell V.; Andrews P.; Roberts D.; Gleeson M.
AUTHOR ADDRESSES
  (Choi D., David.choi@uclh.nhs.uk; Subramanian A.; Elwell V.; Gleeson M.) 
Department of Neurosurgery, National Hospital for Neurology and 
Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom.
(Andrews P.) Department of ENT, Royal National Throat Nose Ear Hospital, 
London, United Kingdom.
(Roberts D.; Gleeson M.) Department of ENT, Guy's and St Thomas' Hospital 
NHS Trust, London, United Kingdom.
CORRESPONDENCE ADDRESS
  D. Choi, Department of Neurosurgery, National Hospital for Neurology and 
Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom. Email: 
David.choi@uclh.nhs.uk
AiP/IP ENTRY DATE
  2014-03-20
FULL RECORD ENTRY DATE
  2014-07-16
SOURCE
  Journal of Neurological Surgery, Part B: Skull Base (2014) 75:3 (165-170). 
Date of Publication: June 2014
VOLUME
  75
ISSUE
  3
FIRST PAGE
  165
LAST PAGE
  170
DATE OF PUBLICATION
  June 2014
ISSN
  2193-6331 (electronic)
  2193-634X
BOOK PUBLISHER
  Thieme Medical Publishers, Inc., custserv@thieme.com
ABSTRACT
  Objectives To compare the complication rates of endoscopic transnasal and 
open maxillotomy approaches for the central skull base. Design Retrospective 
review. Setting Single-center study, London, United Kingdom. Participants 
From 1992 to 2012, 81 patients underwent surgery for skull base lesions, 59 
by maxillotomy and 22 by endoscopy. Main Outcome Measures Total time of 
surgical anesthesia, blood loss, complications, duration of tracheal 
intubation, duration of hospital stay, myelopathy score, and mortality rate. 
Results The surgical time, blood loss, and duration of the postoperative 
intubation period were significantly less with endoscopy (p < 0.001). 
Requirements for intensive care, ward stay, and total hospital stay were 
also significantly less in the endoscopic group (p = 0.01, p < 0.001, and p 
< 0.001, respectively). The complication rate was lower with transnasal 
endoscopic surgery. Conclusion In patients for whom open maxillotomy or 
endoscopic surgery are both feasible, the preference should be to perform 
endoscopic surgery, with better visualization and fewer complications. © 
2014 Georg Thieme Verlag KG Stuttgart New York.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endoscopic surgery; endoscopic transnasal surgery; maxillofacial surgery; maxillotomy; nose surgery; skull base; surgical approach; 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesia; artery injury (complication); article; basilar impression (surgery); benign neoplasm (surgery); brain infarction (complication); cancer surgery; chordoma (surgery); comparative study; controlled study; cranial nerve paralysis (complication); dysphagia (complication); endotracheal intubation; face; female; follow up; hematoma (complication); human; intensive care; internal carotid artery; length of stay; liquorrhea (complication); major clinical study; male; malignant neoplasm (surgery); meningitis (complication); nuclear magnetic resonance imaging; operation duration; operative blood loss; osteotomy; priority journal; retrospective study; sepsis (complication); skull injury; spinal cord disease; surgical infection (complication); surgical mortality; tracheostomy; tumor volume; United Kingdom; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014451202
PUI
  L53052757
DOI
  10.1055/s-0033-1358375
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0033-1358375
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21936331&id=doi:10.1055%2Fs-0033-1358375&atitle=Endoscopic+transnasal+surgery+as+a+replacement+for+maxillotomy+techniques+to+approach+the+central+skull+base%3A+Fewer+complications+and+more+acceptable+to+patients%3F&stitle=J.+Neurol.+Surg.+Part+B+Skull+Base&title=Journal+of+Neurological+Surgery%2C+Part+B%3A+Skull+Base&volume=75&issue=3&spage=165&epage=170&aulast=Choi&aufirst=David&auinit=D.&aufull=Choi+D.&coden=&isbn=&pages=165-170&date=2014&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 435
TITLE
  Esophageal, pharyngeal and hemorrhagic complications occurring in anterior 
cervical surgery: Three illustrative cases
AUTHOR NAMES
  Paradells V.R.; Pérez J.B.C.; Vicente F.J.D.; Florez L.B.; De La Viuda M.C.; Villagrasa F.J.
AUTHOR ADDRESSES
  (Paradells V.R., vrodrigo84@gmail.com; Pérez J.B.C., jbcalata@comz.org; 
Vicente F.J.D., jdiazvicente@telefonica.net; Florez L.B., 
bancesluciano@hotmail.com; De La Viuda M.C., martaclaramonte@hotmail.com; 
Villagrasa F.J., villacomp@yahoo.es) Neurosurgery Division, Hospital Clínico 
Universitario Lozano Blesa de Zaragoza, Avenida San Juan Bosco, 1550009 
Zaragoza, Spain.
CORRESPONDENCE ADDRESS
  V.R. Paradells, Neurosurgery Division, Hospital Clínico Universitario Lozano 
Blesa de Zaragoza, Avenida San Juan Bosco, 1550009 Zaragoza, Spain. Email: 
vrodrigo84@gmail.com
AiP/IP ENTRY DATE
  2014-09-10
FULL RECORD ENTRY DATE
  2014-09-13
SOURCE
  Surgical Neurology International (2014) 5:SUPPL. 3 (S126-S130). Date of 
Publication: 2014
VOLUME
  5
ISSUE
  SUPPL. 3
DATE OF PUBLICATION
  2014
ISSN
  2152-7806 (electronic)
ABSTRACT
  Background: The number of esophageal and pharyngeal perforations occurring 
in anterior cervical surgeries ranges from 0.25% to 1% and 0.2% to 1.2%, 
respectively. Symptoms usually appear postoperatively and are attributed to: 
Local infection, fistula, sepsis, or mediastinitis. Acute postoperative 
hematoma, although very rare (<1%), is the first complication to rule out 
due to its life-threatening complications (e.g. acute respiratory failure). 
Case Description: Over a 36-year period, the author(s) described three 
severe esophageal/pharyngeal complications attributed to anterior cervical 
surgery. As these complications were appropriately recognized/treated, 
patients had favorable outcomes. Conclusions: Anterior cervical spine 
surgery is a safe approach and is associated with few major 
esophageal/pharyngeal complications, which most commonly include transient 
dysphagia and dysphonia. If symptoms persist, patients should be assessed 
for esophageal/pharyngeal defects utilizing appropriate imaging studies. 
Notably, even if the major complications listed above are adequately 
treated, optimal results are in no way guaranteed. Copyright: © 2014 Epstein 
NE.
EMTREE DRUG INDEX TERMS
  antibiotic agent (intravenous drug administration); polyetheretherketone; tranexamic acid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (complication); dysphonia (complication); postoperative complication (complication); spinal hematoma (complication); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; anterior cervical diskectomy and fusion; anterior corpectomy fusion; antibiotic therapy; article; aspiration pneumonia (complication); bleeding (complication); bone graft; bone plate; case report; cervical myelopathy (surgery); cervical spine; cervical spine fracture; device removal; disease severity; endotracheal intubation; esophagography; esophagus foreign body (diagnosis); female; hemostasis; hospital admission; hospital discharge; human; intervertebral disk hernia; joint swelling (complication); laryngoscopy; ligament calcinosis (surgery); male; nasogastric tube; parenteral nutrition; priority journal; respiratory distress (complication); septic shock (complication); spinal cord compression (surgery); spine fusion; spine scintiscanning; spondylolisthesis (diagnosis); surgical approach; thrombocyte aggregation; tracheotomy; traffic accident; 
CAS REGISTRY NUMBERS
  polyetheretherketone (31694-16-3)
  tranexamic acid (1197-18-8, 701-54-2)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014578218
PUI
  L373866662
DOI
  10.4103/2152-7806.130673
FULL TEXT LINK
  http://dx.doi.org/10.4103/2152-7806.130673
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2F2152-7806.130673&atitle=Esophageal%2C+pharyngeal+and+hemorrhagic+complications+occurring+in+anterior+cervical+surgery%3A+Three+illustrative+cases&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=5&issue=SUPPL.+3&spage=&epage=&aulast=Paradells&aufirst=V%C3%ADctor+Rodrigo&auinit=V.R.&aufull=Paradells+V.R.&coden=&isbn=&pages=-&date=2014&auinit1=V&auinitm=R
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 436
TITLE
  Comparison of perioperative complications following staged versus one-day 
anterior and posterior cervical decompression and fusion crossing the 
cervico-thoracic junction
AUTHOR NAMES
  Siemionow K.; Tyrakowski M.; Patel K.; Neckrysh S.
AUTHOR ADDRESSES
  (Siemionow K.; Tyrakowski M., marcintyrak@gmail.com; Patel K.) Department of 
Orthopaedic Surgery, University of Illinois at Chicago, Chicago, United 
States.
(Tyrakowski M., marcintyrak@gmail.com) Department of Orthopaedics, Pediatric 
Orthopaedics and Traumatology, The Medical Centre of Postgraduate Education, 
Otwock, Poland.
(Neckrysh S.) Department of Neurosurgery, University of Illinois at Chicago, 
Chicago, United States.
CORRESPONDENCE ADDRESS
  M. Tyrakowski, Department of Orthopaedic Surgery, University of Illinois at 
Chicago, 835 South Wolcott Ave, Chicago, United States.
AiP/IP ENTRY DATE
  2015-07-02
FULL RECORD ENTRY DATE
  2015-07-07
SOURCE
  Neurologia i Neurochirurgia Polska (2014) 48:6 (403-409). Date of 
Publication: 2014
VOLUME
  48
ISSUE
  6
FIRST PAGE
  403
LAST PAGE
  409
DATE OF PUBLICATION
  2014
ISSN
  1897-4260 (electronic)
  0028-3843
BOOK PUBLISHER
  Elsevier
ABSTRACT
  Introduction: Multilevel cervical pathology may be treated via combined 
anterior cervical decompression and fusion (ACDF) followed by posterior 
spinal instrumented fusion (PSIF) crossing the cervico-thoracic junction. 
The purpose of the study was to compare perioperative complication rates 
following staged versus same day ACDF combined with PSIF crossing the 
cervico-thoracic junction. Material and methods: A retrospective review of 
consecutive patients undergoing ACDF followed by PSIF crossing the 
cervico-thoracic junction at a single institution was performed. Patients 
underwent either same day (group A) or staged with one week interval 
surgeries (group B). The minimum follow-up was 12 months. Results: 
Thirty-five patients (14 females and 21 males) were analyzed. The average 
age was 60 years (37–82 years). There were 12 patients in group A and 23 in 
group B. Twenty-eight complications noted in 14 patients (40%) included: 
dysphagia in 13 (37%), dysphonia in 6 (17%), post-operative reintubation in 
4 (11%), vocal cords paralysis, delirium, superficial incisional infection 
and cerebrospinal fluid leakage each in one case. Significant differences 
comparing group A vs. B were found in: the number of levels fused 
posteriorly (5 vs. 7; p = 0.002), total amount of intravenous fluids (3233 
ml vs. 4683 ml; p = 0.03), length of hospital stay (10 vs. 18 days; p = 
0.03) and transfusion of blood products (0 vs. 9 patients). Smoking and 
cervical myelopathy were the most important risk factors for perioperative 
complications regardless of the group. Conclusions: Staging anterior 
cervical decompression and fusion with posterior cervical instrumented 
fusion 1 week apart does not decrease the incidence of perioperative 
complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical decompression and fusion; anterior spine fusion; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cervical myelopathy; clinical article; delirium (complication); dysphagia (complication); dysphonia (complication); female; human; intermethod comparison; intubation; length of stay; liquorrhea (complication); male; nuclear magnetic resonance imaging; operative blood loss; pneumonia (complication); retrospective study; risk factor; surgical infection (complication); tracheostomy; vocal cord paralysis (complication); 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015161643
MEDLINE PMID
  25482251 (http://www.ncbi.nlm.nih.gov/pubmed/25482251)
PUI
  L605014585
DOI
  10.1016/j.pjnns.2014.10.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pjnns.2014.10.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18974260&id=doi:10.1016%2Fj.pjnns.2014.10.001&atitle=Comparison+of+perioperative+complications+following+staged+versus+one-day+anterior+and+posterior+cervical+decompression+and+fusion+crossing+the+cervico-thoracic+junction&stitle=Neurol.+Neurochir.+Pol.&title=Neurologia+i+Neurochirurgia+Polska&volume=48&issue=6&spage=403&epage=409&aulast=Siemionow&aufirst=Kris&auinit=K.&aufull=Siemionow+K.&coden=NNPOB&isbn=&pages=403-409&date=2014&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 437
TITLE
  The process of prehospital airway management: Challenges and solutions 
during paramedic endotracheal intubation
AUTHOR NAMES
  Prekker M.E.; Kwok H.; Shin J.; Carlbom D.; Grabinsky A.; Rea T.D.
AUTHOR ADDRESSES
  (Prekker M.E., mprekker@uw.edu; Kwok H.; Carlbom D.; Rea T.D.) Department of 
Medicine, University of Washington School of Medicine, Seattle, WA, United 
States.
(Prekker M.E., mprekker@uw.edu; Carlbom D.) Division of Pulmonary and 
Critical Care Medicine, Harborview Medical Center, Seattle, WA, United 
States.
(Kwok H.) Division of Emergency Medicine, University of Washington School of 
Medicine, Seattle, WA, United States.
(Shin J.; Rea T.D.) Emergency Medical Services Division, Public 
Health-Seattle and King County, Seattle, WA, United States.
(Grabinsky A.) Department of Anesthesiology, University of Washington School 
of Medicine, Seattle, WA, United States.
AiP/IP ENTRY DATE
  2014-03-07
FULL RECORD ENTRY DATE
  2014-06-11
SOURCE
  Critical Care Medicine (2014) 42:6 (1372-1378). Date of Publication: June 
2014
VOLUME
  42
ISSUE
  6
FIRST PAGE
  1372
LAST PAGE
  1378
DATE OF PUBLICATION
  June 2014
ISSN
  1530-0293 (electronic)
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins, LRorders@phl.lrpub.com
ABSTRACT
  OBJECTIVES: Endotracheal intubation success rates in the prehospital setting 
are variable. Our objective was to describe the challenges encountered and 
corrective actions taken during the process of endotracheal intubation by 
paramedics. DESIGN: Analysis of prehospital airway management using a 
prospective registry that was linked to an emergency medical services 
administrative database. SETTING: Emergency medical services system serving 
King County, Washington, 2006-2011. Paramedics in this system have the 
capability to administer neuromuscular blocking agents to facilitate 
intubation (i.e., rapid sequence intubation). PATIENTS: A total of 7,523 
patients more than 12 years old in whom paramedics attempted prehospital 
endotracheal intubation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: 
An intubation attempt was defined as the introduction of the laryngoscope 
into the patient's mouth, and the attempt concluded when the laryngoscope 
was removed from the mouth. Endotracheal intubation was successful on the 
first attempt in 77% and ultimately successful in 99% of patients (7,433 of 
7,523). Paramedics used a rapid sequence intubation strategy on 54% of first 
attempts. Among the subset with a failed first attempt (n = 1,715), bodily 
fluids obstructing the laryngeal view (50%), obesity (28%), patient 
positioning (17%), and facial or spinal trauma (6%) were identified as 
challenges to intubation. A variety of adjustments were made to achieve 
intubation success, including upper airway suctioning (used in 43% of 
attempts resulting in success), patient repositioning (38%), rescue bougie 
use (19%), operator change (16%), and rescue rapid sequence intubation (6%). 
Surgical cricothyrotomy (0.4%, n = 27) and bag-valve-mask ventilation (0.8%, 
n = 60) were rarely performed by paramedics as final rescue airway 
strategies. CONCLUSIONS: Airway management in the prehospital setting has 
substantial challenges. Success can require a collection of adjustments that 
involve equipment, personnel, and medication often in a simultaneous 
fashion. © 2014 by the Society of Critical Care Medicine and Lippincott 
Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  neuromuscular blocking agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency care; endotracheal intubation; paramedical personnel; respiration control; 
EMTREE MEDICAL INDEX TERMS
  article; assisted ventilation; body fluid; bougie; critically ill patient; emergency health service; heart arrest; human; jet ventilation; laryngoscope; larynx; major clinical study; manual emergency ventilator; obesity; patient positioning; priority journal; spine injury; suction; total quality management; tracheotomy; upper respiratory tract; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014358189
PUI
  L53034826
DOI
  10.1097/CCM.0000000000000213
FULL TEXT LINK
  http://dx.doi.org/10.1097/CCM.0000000000000213
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15300293&id=doi:10.1097%2FCCM.0000000000000213&atitle=The+process+of+prehospital+airway+management%3A+Challenges+and+solutions+during+paramedic+endotracheal+intubation&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=42&issue=6&spage=1372&epage=1378&aulast=Prekker&aufirst=Matthew+E.&auinit=M.E.&aufull=Prekker+M.E.&coden=CCMDC&isbn=&pages=1372-1378&date=2014&auinit1=M&auinitm=E
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 438
TITLE
  Development of a spinal epidural abscess masked by critical illness 2C01, 
C300
AUTHOR NAMES
  Chandler B.; Francis J.; Harper D.
AUTHOR ADDRESSES
  (Harper D.) Anaesthetic Department, Scarborough Hospital, United Kingdom.
(Chandler B., ben.chandler@nhs.net; Francis J.)
AiP/IP ENTRY DATE
  2014-08-07
FULL RECORD ENTRY DATE
  2014-08-13
SOURCE
  Journal of the Intensive Care Society (2014) 15:3 (235-237). Date of 
Publication: July 2014
VOLUME
  15
ISSUE
  3
FIRST PAGE
  235
LAST PAGE
  237
DATE OF PUBLICATION
  July 2014
ISSN
  1751-1437
BOOK PUBLISHER
  Stansted News Ltd, claims@sagepub.com
ABSTRACT
  We describe a case of severe neurological injury secondary to an epidural 
abscess that developed during the course of critical illness. It was caused 
by an oesophageal perforation that developed into an invasive abscess while 
the patient was being treated in the intensive care unit (ICU) for 
respiratory failure. We discuss spinal epidural abscesses, and the 
importance of searching for an alternative diagnosis in patients with 
weakness. © The Intensive Care Society 2014.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy, intravenous drug administration); C reactive protein (endogenous compound); clavulanic acid; fluconazole (drug therapy); metronidazole (drug therapy); noradrenalin; penicillin G (drug therapy); ticarcillin; timentin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidural abscess (diagnosis, surgery); spinal epidural abscess (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; article; artificial ventilation; aspiration pneumonia (drug therapy); atelectasis; bronchoscopy; case report; computer assisted tomography; confusion; esophageal stent; esophagus perforation; female; fever; Glasgow coma scale; human; leukocyte count; lung edema; mediastinitis (drug therapy); Medical Research Council power score; oxygen desaturation; polyneuropathy; quadriplegia; respiratory failure; scoring system; shoulder pain; thorax radiography; tracheostomy; 
CAS REGISTRY NUMBERS
  C reactive protein (9007-41-4)
  clavulanic acid (58001-44-8)
  fluconazole (86386-73-4)
  metronidazole (39322-38-8, 443-48-1)
  noradrenalin (1407-84-7, 51-41-2)
  penicillin G (1406-05-9, 61-33-6)
  ticarcillin (29457-07-6, 34787-01-4, 4697-14-7)
  timentin (86482-18-0)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Gastroenterology (48)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014510977
PUI
  L373647297
DOI
  10.1177/175114371401500312
FULL TEXT LINK
  http://dx.doi.org/10.1177/175114371401500312
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17511437&id=doi:10.1177%2F175114371401500312&atitle=Development+of+a+spinal+epidural+abscess+masked+by+critical+illness+2C01%2C+C300&stitle=J.+Intensive+Care+Soc.&title=Journal+of+the+Intensive+Care+Society&volume=15&issue=3&spage=235&epage=237&aulast=Harper&aufirst=D.&auinit=D.&aufull=Harper+D.&coden=&isbn=&pages=235-237&date=2014&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 439
TITLE
  Experience with intraoperative navigation and imaging during endoscopic 
transnasal spinal approaches to the foramen magnum and odontoid.
AUTHOR NAMES
  Choudhri O.; Mindea S.A.; Feroze A.; Soudry E.; Chang S.D.; Nayak J.V.
AUTHOR ADDRESSES
  (Choudhri O.) Departments of Neurosurgery and.
(Mindea S.A.; Feroze A.; Soudry E.; Chang S.D.; Nayak J.V.)
CORRESPONDENCE ADDRESS
  O. Choudhri,
FULL RECORD ENTRY DATE
  2014-11-24
SOURCE
  Neurosurgical focus (2014) 36:3 (E4). Date of Publication: Mar 2014
VOLUME
  36
ISSUE
  3
DATE OF PUBLICATION
  Mar 2014
ISSN
  1092-0684 (electronic)
ABSTRACT
  In this study the authors share their experience using intraoperative spinal 
navigation and imaging for endoscopic transnasal approaches to the odontoid 
in 5 patients undergoing C1-2 surgery for basilar invagination at Stanford 
Hospital and Clinics from 2010 to 2013. Of these 5 patients undergoing C1-2 
surgery for basilar invagination, 4 underwent a 2-tiered anterior C1-2 
resection with posterior occipitocervical fusion during a first stage 
surgery, followed by endoscopic endonasal odontoidectomy in a separate 
setting. Intraoperative stereotactic navigation was performed using a 
surgical navigation system in all cases. Navigation accuracy, characterized 
as target registration error, ranged between 0.8 mm and 2 mm, with an 
average of 1.2 mm. Intraoperative imaging using a CT scanner was also 
performed in 2 patients. Endoscopic decompression of the brainstem was 
achieved in all patients, and no intraoperative complications were 
encountered. All patients were extubated within 24 hours after surgery and 
were able to swallow within 48 hours. After appropriate initial 
reconstruction of the defect at the craniocervical junction, no 
postoperative CSF leakage, arterial injury, or need for reoperation was 
encountered; 1 patient developed mild postoperative velopharyngeal 
insufficiency that resolved by the 6-month follow-up evaluation. There were 
no deaths and no patients required tracheostomy placement. The average 
inpatient stay after surgery varied between 72 and 96 hours, without 
extended intensive care unit stays for any patient. Technologies such as 
intraoperative CT scanning and merged MRI/CT can provide the surgeon with 
detailed, virtual real-time information about the extent of complex 
endoscopic vertebral segment resection and brainstem decompression and 
lessens the prospect of revision or secondary procedures in this challenging 
surgical corridor. Moreover, patients experience limited morbidity and can 
tolerate early oral intake after transnasal endoscopic odontoidectomy. 
Essential to the successful undertaking of these endoscopic adventures is 1) 
an understanding of the endoscopic nasal, skull base, and neurovascular 
anatomy; 2) advanced and extended-length instrumentation including 
navigation; and 3) a team approach between experienced rhinologists and 
spine surgeons comfortable with endoscopic skull base techniques.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endoscopy; foramen magnum (surgery); neuronavigation; odontoid process (surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; article; decompression surgery; female; human; male; methodology; middle aged; nuclear magnetic resonance imaging; patient monitoring; reoperation; spine fusion; very elderly; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  24580005 (http://www.ncbi.nlm.nih.gov/pubmed/24580005)
PUI
  L373990850
DOI
  10.3171/2014.1.FOCUS13533
FULL TEXT LINK
  http://dx.doi.org/10.3171/2014.1.FOCUS13533
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10920684&id=doi:10.3171%2F2014.1.FOCUS13533&atitle=Experience+with+intraoperative+navigation+and+imaging+during+endoscopic+transnasal+spinal+approaches+to+the+foramen+magnum+and+odontoid.&stitle=Neurosurg+Focus&title=Neurosurgical+focus&volume=36&issue=3&spage=&epage=&aulast=Choudhri&aufirst=Omar&auinit=O.&aufull=Choudhri+O.&coden=&isbn=&pages=-&date=2014&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2014 Medline is the source for the citation and abstract of this 
record.

RECORD 440
TITLE
  Procedure-based complications to guide informed consent: Analysis of society 
of thoracic surgeons-congenital heart surgery database
AUTHOR NAMES
  Mavroudis C.; Mavroudis C.D.; Jacobs J.P.; Siegel A.; Pasquali S.K.; Hill K.D.; Jacobs M.L.
AUTHOR ADDRESSES
  (Mavroudis C., constantine.mavroudis.md@flhosp.org; Siegel A.) Johns Hopkins 
Children's Heart Surgery, Florida Hospital for Children, 2501 N Orange Ave, 
Ste 540, Orlando, FL 32804, United States.
(Mavroudis C.D.) Division of Cardiothoracic Surgery, University of 
Pennsylvania, Philadelphia, PA, United States.
(Jacobs J.P.) Johns Hopkins Children's Heart Surgery, All Children's 
Hospital, St. Petersburg, FL, United States.
(Pasquali S.K.) Department of Pediatrics and Communicable Diseases, 
University of Michigan, Ann Arbor, MI, United States.
(Hill K.D.) Duke Clinical Research Institute, Duke University School of 
Medicine, Durham, NC, United States.
(Jacobs M.L.) Department of Surgery, Johns Hopkins University School of 
Medicine, Baltimore, MD, United States.
CORRESPONDENCE ADDRESS
  C. Mavroudis, Johns Hopkins Children's Heart Surgery, Florida Hospital for 
Children, 2501 N Orange Ave, Ste 540, Orlando, FL 32804, United States. 
Email: constantine.mavroudis.md@flhosp.org
AiP/IP ENTRY DATE
  2014-04-04
FULL RECORD ENTRY DATE
  2014-05-26
SOURCE
  Annals of Thoracic Surgery (2014) 97:5 (1838-1851). Date of Publication: May 
2014
VOLUME
  97
ISSUE
  5
FIRST PAGE
  1838
LAST PAGE
  1851
DATE OF PUBLICATION
  May 2014
ISSN
  1552-6259 (electronic)
  0003-4975
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background Informed consent refers to the process by which physicians and 
patients engage in a dialogue to explain and comprehend the nature, 
alternatives, and risks of a procedure or course of therapy. The goal of 
this study is to better "inform the process of informed consent" by offering 
empirically derived procedural complication lists that provide objective 
contemporary data that surgeons may share with patients and families. 
Methods The Society of Thoracic Surgeons Congenital Heart Surgery Database 
was queried for complications for 12 congenital heart operations (2010 to 
2011) performed across all Society of Thoracic Surgeons-European Association 
of Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) risk categories. 
Results The 12 index procedures reviewed for rates of complications were 
repair of atrial septal defect (ASD), ventricular septal defect (VSD), 
atrioventricular septal defect (AVSD), tetralogy of Fallot (TOF), 
coarctation, and truncus arteriosus, as well as arterial switch operation 
(ASO), ASO-VSD, BiGlenn, Fontan, Norwood procedure, and systemic to 
pulmonary artery (S-P) shunt. Arrhythmia was the most frequent complication 
for VSD (5.8%), TOF (8.9%), and AVSD (14.7%) repairs. There was a high rate 
of sternum left open (planned, unplanned) for ASO (26%, 7%), ASO-VSD (29%, 
10%), truncus repair (41%, 11%), and Norwood (63%, 7%). The most frequent 
complications for other procedures include ASD (unplanned readmission, 
1.9%), BiGlenn (chylothorax, 7%), Fontan (pleural effusion, 16%), S-P shunt 
(reintubation, 10.6%), and coarctation (reintubation, 5.2%). Conclusions The 
informed consent process for congenital heart surgery may be served by 
accurate contemporary data on occurrence of complications. While a threshold 
rate of occurrence of individual complications may guide the physician, rare 
but important debilitating complications should also be discussed 
irrespective of frequency. We propose to better inform the process of 
informed consent by providing objective complications data. © 2014 by The 
Society of Thoracic Surgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  heart surgery; informed consent; peroperative complication (complication); postoperative complication (complication, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication, therapy); aortic coarctation (surgery); aortic surgery; arterial switch operation; arterial trunk; article; artificial heart pacemaker; artificial ventilation; assisted circulation; atrioventricular septal defect (surgery); atrioventricular septal defect repair; bacterial endocarditis (complication); BiGlenn procedure; Blalock Taussig shunt; cardiac surgeon; cardioversion; cavopulmonary connection; cerebrovascular accident (complication); chylothorax (complication); defibrillation; dialysis; diaphragm paralysis (complication); Fallot tetralogy (surgery); Fallot tetralogy surgery; family; Fontan procedure; forward heart failure (complication); heart arrest (complication); heart arrhythmia (complication, therapy); heart atrium septum defect (surgery); heart atrium septum defect repair; heart catheterization; heart failure (complication); heart ventricle septum defect (surgery); heart ventricle septum defect repair; hospital discharge; hospital readmission; human; hypertensive crisis (complication); information dissemination; intubation; mediastinitis (complication); medical society; multiple organ failure (complication); neurologic disease (complication); Norwood procedure; pericardial effusion (complication, surgery); peripheral nerve injury (complication); pleura effusion (complication, surgery); pneumonia (complication); pneumothorax (complication); postoperative hemorrhage (complication); priority journal; pulmonary hypertension (complication); pulmonary vein obstruction (complication); reoperation; respiratory failure (complication, surgery, therapy); seizure (complication); sepsis (complication); spinal cord injury (complication); sternotomy; sternum; surgical drainage; surgical infection (complication); surgical mortality; surgical risk; thorax drainage; tracheostomy; vein occlusion (complication); vocal cord disorder (complication); wound dehiscence (complication, surgery); 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014310153
MEDLINE PMID
  24680033 (http://www.ncbi.nlm.nih.gov/pubmed/24680033)
PUI
  L53074327
DOI
  10.1016/j.athoracsur.2013.12.037
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2013.12.037
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15526259&id=doi:10.1016%2Fj.athoracsur.2013.12.037&atitle=Procedure-based+complications+to+guide+informed+consent%3A+Analysis+of+society+of+thoracic+surgeons-congenital+heart+surgery+database&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=97&issue=5&spage=1838&epage=1851&aulast=Mavroudis&aufirst=Constantine&auinit=C.&aufull=Mavroudis+C.&coden=ATHSA&isbn=&pages=1838-1851&date=2014&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 441
TITLE
  Transient hyperckemia in the setting of neuromyelitis optica (NMO)
AUTHOR NAMES
  Malik R.; Lewis A.; Cree B.A.C.; Ratelade J.; Rossi A.; Verkman A.S.; Bollen A.W.; Ralph J.W.
AUTHOR ADDRESSES
  (Malik R., rabia.malik@ucsf.edu; Cree B.A.C.; Ralph J.W.) UCSF, Neurology, 
505 Parnassus Avenue Box 0114 M-798, San Francisco, United States.
(Lewis A.) Department of Neurology, Kaiser Permanente, San Francisco, United 
States.
(Ratelade J.; Rossi A.; Verkman A.S.) Departments of Medicine and 
Physiology, UCSF Medical Center, San Francisco, United States.
(Bollen A.W.) Division of Neuropathology, Department of Pathology, UCSF 
Medical Center, San Francisco, United States.
CORRESPONDENCE ADDRESS
  R. Malik, UCSF, Neurology, 505 Parnassus Avenue Box 0114 M-798, San 
Francisco, United States.
AiP/IP ENTRY DATE
  2015-08-20
FULL RECORD ENTRY DATE
  2015-08-25
SOURCE
  Muscle and Nerve (2014) 50:5 (859-862). Date of Publication: 1 Nov 2014
VOLUME
  50
ISSUE
  5
FIRST PAGE
  859
LAST PAGE
  862
DATE OF PUBLICATION
  1 Nov 2014
ISSN
  1097-4598 (electronic)
  0148-639X
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Introduction: Neuromyelitis optica (NMO) is characterized by inflammatory 
demyelinating lesions of the spinal cord and optic nerves from an autoimmune 
response against water channel aquaporin-4 (AQP4). We report 2 patients with 
transient hyperCKemia associated with NMO suggesting possible skeletal 
muscle damage. Methods: Patient 1 was a 72-year-old man who presented with 
muscle soreness and elevated serum creatine kinase (CK) preceding an initial 
attack of NMO. Patient 2 was a 25-year-old woman with an established 
diagnosis of NMO who presented with diffuse myalgias, proximal upper 
extremity weakness, and hyperCKemia. Muscle biopsies were obtained for 
histopathologic evaluation, protein gel electrophoresis, immunofluorescence, 
and complement staining. Results: In both patients the muscle showed only 
mild variation in fiber diameter. There were no inflammatory changes or 
muscle fiber necrosis, though there was reduced AQP4 expression and 
deposition of activated complement. Conclusions: Complement-mediated 
sarcolemmal injury may lead to hyperCKemia in NMO.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  creatine kinase (endogenous compound); 
EMTREE DRUG INDEX TERMS
  alanine aminotransferase (endogenous compound); aquaporin 4 (endogenous compound); aquaporin 4 antibody (endogenous compound); aspartate aminotransferase (endogenous compound); prednisone (drug therapy); rituximab (drug therapy); steroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  creatine kinase blood level; hyperckemia; myelooptic neuropathy (drug therapy, diagnosis, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; alanine aminotransferase blood level; arm weakness; article; aspartate aminotransferase blood level; case report; endotracheal intubation; female; human; human tissue; immunofluorescence; infectious complication (complication); intensive care unit; lack of drug effect; male; muscle biopsy; muscle injury; muscle necrosis; nuclear magnetic resonance imaging; paresthesia; plasmapheresis; priority journal; protein expression; respiratory distress; tracheostomy; young adult; 
CAS REGISTRY NUMBERS
  alanine aminotransferase (9000-86-6, 9014-30-6)
  aquaporin 4 (175960-54-0)
  aspartate aminotransferase (9000-97-9)
  creatine kinase (9001-15-4)
  prednisone (53-03-2)
  rituximab (174722-31-7)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015301042
MEDLINE PMID
  24862586 (http://www.ncbi.nlm.nih.gov/pubmed/24862586)
PUI
  L605641267
DOI
  10.1002/mus.24298
FULL TEXT LINK
  http://dx.doi.org/10.1002/mus.24298
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10974598&id=doi:10.1002%2Fmus.24298&atitle=Transient+hyperckemia+in+the+setting+of+neuromyelitis+optica+%28NMO%29&stitle=Muscle+Nerve&title=Muscle+and+Nerve&volume=50&issue=5&spage=859&epage=862&aulast=Malik&aufirst=Rabia&auinit=R.&aufull=Malik+R.&coden=MUNED&isbn=&pages=859-862&date=2014&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 442
TITLE
  Basic science and spine literature document bone morphogenetic protein 
increases cancer risk
AUTHOR NAMES
  Epstein N.E.
AUTHOR ADDRESSES
  (Epstein N.E., nancy.epsteinmd@gmail.com) Department of Neurosurgical Spine 
and Education, Winthrop University Hospital, Mineola, United States.
CORRESPONDENCE ADDRESS
  N.E. Epstein, Department of Neurosurgical Spine and Education, Winthrop 
University Hospital, Mineola, United States.
AiP/IP ENTRY DATE
  2015-04-16
FULL RECORD ENTRY DATE
  2015-04-20
SOURCE
  Surgical Neurology International (2014) 5:15 (S552-S560). Date of 
Publication: 30 Dec 2014
VOLUME
  5
ISSUE
  15
FIRST PAGE
  S552
LAST PAGE
  S560
DATE OF PUBLICATION
  30 Dec 2014
ISSN
  2152-7806 (electronic)
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
ABSTRACT
  Background: Increasingly, clinical articles document that bone morphogenetic 
protein (BMP/INFUSE: Medtronic, Memphis, TN, USA) and its derivatives 
utilized in spinal surgery increase the risk of developing cancer. However, 
there is also a large body of basic science articles that also document that 
various types of BMP and other members of the TGF-Beta (transforming growth 
factor beta) family promote the growth of different types of cancers. 
Methods: This review looks at many clinical articles citing BMP/INFUSE's 
role, largely "off-label", in contributing to complications encountered 
during spinal surgery. Next, however, specific attention is given to the 
clinical and basic science literature regarding how BMP and its derivatives 
(e.g. members of the TGF-beta family) may also impact the development of 
breast and other cancers. Results: Utilizing BMP/INFUSE in spine surgery 
increased the risk of cancers/new malignancy as documented in several 
studies. For example, Carragee et al. found that for single-level 
instrumented posterolateral fusions (PLF) using high-dose rhBMP-2 (239 
patients) vs. autograft (control group; n = 224), the risks of new cancers 
at 2 and 5 years postoperatively were increased. In laboratory studies, 
BMP's along with other members of the TGF-Beta family also 
modulated/contributed to the proliferation/differentiation of breast cancer 
(e.g. bone formation/turnover, breast cancer-related solid tumors, and 
metastases), lung, adrenal, and colon cancer. Conclusions: BMP/INFUSE when 
utilized clinically in spinal fusion surgery appears to promote cancer at 
higher rates than observed in the overall population. Furthermore, BMP and 
TGF-beta are correlated with increased cancer growth both in the clinic and 
the laboratory.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  recombinant bone morphogenetic protein 2 (adverse drug reaction, clinical 
trial, drug therapy); 
EMTREE DRUG INDEX TERMS
  estrogen receptor alpha (endogenous compound); osteopontin (endogenous compound); transforming growth factor beta; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer risk; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  adenocarcinoma cell line; adrenal cancer (complication, side effect); angiogenesis; anterior interbody lumbar fusion; arachnoiditis (side effect); article; autograft; bone graft; bone turnover; breast calcification (complication); breast cancer (complication, side effect); breast epithelium cell; cancer growth; carcinogenesis (complication); cell activity; cell differentiation; cell migration; cell proliferation; colon cancer (complication, side effect); degenerative disease (drug therapy); disease severity; drug efficacy; drug megadose; drug safety; dysphagia (side effect); edema (side effect); ejaculation disorder (side effect); fibroblast; gene expression; genetic variability; hematoma (side effect); heterotopic ossification (side effect); human; infection (side effect); intermethod comparison; intubation; lumbar spine degenerative disease (drug therapy); lumbar spine degenerative disease (drug therapy); lung cancer (complication, side effect); medical literature; nerve root injury (side effect); neurologic disease (side effect); nonhuman; off label drug use; ossification; posterolateral fusion; postoperative complication (complication); postoperative period; priority journal; protein expression; radiculitis (side effect); randomized controlled trial (topic); seroma (side effect); signal transduction; swelling (side effect); tracheostomy; tumor invasion; 
DEVICE TRADE NAMES
  INFUSE  , United StatesMedtronic

DEVICE MANUFACTURERS
   (United States)Medtronic
CAS REGISTRY NUMBERS
  osteopontin (106441-73-0)
  recombinant bone morphogenetic protein 2 (246539-15-1)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015904075
PUI
  L603642711
DOI
  10.4103/2152-7806.148039
FULL TEXT LINK
  http://dx.doi.org/10.4103/2152-7806.148039
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2F2152-7806.148039&atitle=Basic+science+and+spine+literature+document+bone+morphogenetic+protein+increases+cancer+risk&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=5&issue=15&spage=S552&epage=S560&aulast=Epstein&aufirst=Nancy+E.&auinit=N.E.&aufull=Epstein+N.E.&coden=&isbn=&pages=S552-S560&date=2014&auinit1=N&auinitm=E
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 443
TITLE
  Surgical emergencies in oncology
AUTHOR NAMES
  Bosscher M.R.F.; van Leeuwen B.L.; Hoekstra H.J.
AUTHOR ADDRESSES
  (Bosscher M.R.F., m.r.f.bosscher@umcg.nl; van Leeuwen B.L., 
b.l.van.leeuwen@umcg.nl; Hoekstra H.J., h.j.hoekstra@umcg.nl) Department of 
Surgical Oncology, University of Groningen, University Medical Center 
Groningen, HPC BA31, P.O. Box 30.001, 9700 RB Groningen, Netherlands.
CORRESPONDENCE ADDRESS
  M.R.F. Bosscher, Department of Surgical Oncology, University of Groningen, 
University Medical Center Groningen, HPC BA31, P.O. Box 30.001, 9700 RB 
Groningen, Netherlands. Email: m.r.f.bosscher@umcg.nl
AiP/IP ENTRY DATE
  2014-06-04
FULL RECORD ENTRY DATE
  2014-08-08
SOURCE
  Cancer Treatment Reviews (2014) 40:8 (1028-1036). Date of Publication: 
September 2014
VOLUME
  40
ISSUE
  8
FIRST PAGE
  1028
LAST PAGE
  1036
DATE OF PUBLICATION
  September 2014
ISSN
  1532-1967 (electronic)
  0305-7372
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  An oncologic emergency is defined as an acute, potentially life threatening 
condition in a cancer patient that has developed as a result of the 
malignant disease or its treatment. Many oncologic emergencies are signs of 
advanced, end-stage malignant disease. Oncologic emergencies can be divided 
into medical or surgical. The literature was reviewed to construct a summary 
of potential surgical emergencies in oncology that any surgeon can be 
confronted with in daily practice, and to offer insight into the current 
approach for these wide ranged emergencies.Cancer patients can experience 
symptoms of obstruction of different structures and various causes. 
Obstruction of the gastrointestinal tract is the most frequent condition 
seen in surgical practice. Further surgical emergencies include infections 
due to immune deficiency, perforation of the gastrointestinal tract, 
bleeding events, and pathological fractures.For the institution of the 
appropriate treatment for any emergency, it is important to determine the 
underlying cause, since emergencies can be either benign or malignant of 
origin. Some emergencies are well managed with conservative or non-invasive 
treatment, whereas others require emergency surgery. The patient's 
performance status, cancer stage and prognosis, type and severity of the 
emergency, and the patient's wishes regarding invasiveness of treatment are 
essential during the decision making process for optimal management. © 2014 
Elsevier Ltd.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer patient; emergency; 
EMTREE MEDICAL INDEX TERMS
  airway obstruction; biliary tract drainage; bleeding; cancer hormone therapy; cholecystectomy; cholecystitis; cholelithiasis; cholestasis; colon perforation; colorectal cancer; digestive system perforation; diverticulitis; endoscopic sphincterotomy; esophagus cancer; esophagus obstruction; external beam radiotherapy; gallbladder perforation; gastrectomy; gastrointestinal obstruction; gastrojejunostomy; gastrostomy; human; immune deficiency; infection; intestine obstruction; intestine volvulus; intussusception; jejunostomy; laparotomy; malnutrition; melanoma; metastasis; ovary cancer; palliative therapy; patient selection; pelvis cancer; quality of life; radiation enteropathy; review; small intestine obstruction; spinal cord compression; stomach cancer; stomach obstruction; stomach paresis; tracheotomy; tumor perforation; urinary tract obstruction; 
EMBASE CLASSIFICATIONS
  Cancer (16)
  Public Health, Social Medicine and Epidemiology (17)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014498386
MEDLINE PMID
  24933674 (http://www.ncbi.nlm.nih.gov/pubmed/24933674)
PUI
  L53152963
DOI
  10.1016/j.ctrv.2014.05.005
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ctrv.2014.05.005
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15321967&id=doi:10.1016%2Fj.ctrv.2014.05.005&atitle=Surgical+emergencies+in+oncology&stitle=Cancer+Treat.+Rev.&title=Cancer+Treatment+Reviews&volume=40&issue=8&spage=1028&epage=1036&aulast=Bosscher&aufirst=M.R.F.&auinit=M.R.F.&aufull=Bosscher+M.R.F.&coden=CTRED&isbn=&pages=1028-1036&date=2014&auinit1=M&auinitm=R.F.
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 444
TITLE
  Successful liver transplantation in a patient with quadriparesis: A case 
report
AUTHOR NAMES
  Taesombat W.; Nonthasoot B.; Sirichindakul B.; Supaphol J.; Nivatwongs S.
AUTHOR ADDRESSES
  (Taesombat W., t.wipusit@gmail.com; Nonthasoot B.; Sirichindakul B.; 
Supaphol J.; Nivatwongs S.) Department of Surgery, King Chulalongkorn 
Memorial Hospital, Chulalongkorn University, Bangkok 10300, Thailand.
CORRESPONDENCE ADDRESS
  W. Taesombat, Department of Surgery, King Chulalongkorn Memorial Hospital, 
Chulalongkorn University, Bangkok 10300, Thailand. Email: 
t.wipusit@gmail.com
AiP/IP ENTRY DATE
  2014-05-09
FULL RECORD ENTRY DATE
  2014-05-20
SOURCE
  Transplantation Proceedings (2014) 46:3 (1001-1002). Date of Publication: 
April 2014
VOLUME
  46
ISSUE
  3
FIRST PAGE
  1001
LAST PAGE
  1002
DATE OF PUBLICATION
  April 2014
ISSN
  1873-2623 (electronic)
  0041-1345
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Major abdominal surgeries, including liver transplantation, are considered 
high-risk procedures for patients with respiratory muscle dysfunction, such 
as patients with quadriparesis, due to possible fatal postoperative 
pulmonary complications. We report on a 57-year-old male patient with 
longstanding quadriparesis due to fifth cervical spine injury from a traffic 
accident who suffered from decompensated liver cirrhosis related to 
hepatitis C infection and hepatocellular carcinoma. A preoperative pulmonary 
function test showed forced expiratory volume in 1 minute (FEV(1)) 1.06 L, 
which was a risk for pulmonary complications. The patient required 
respiratory training. Cadaveric liver transplantation was performed 
successfully without surgical complications. The patient was extubated on 
the fourth day after surgery and initially did well. However, on the eighth 
postoperative day, an episode of status epilepticus from metabolic 
derangement developed. After controlling seizure with anticonvulsive 
medication and sedation, the patient was reintubated due to hypoventilation. 
Chest radiograph showed upper lung atelectasis. Due to this complication, 
tracheostomy was performed. The patient's condition gradually improved. He 
was ultimately discharged on the 45th postoperative day. Two months after 
the transplantation, liver functions were normal and the patient could 
breathe spontaneously without tracheostomy and had good quality of life. In 
conclusion, this is, to our knowledge, the first report of liver 
transplantation in a patient with quadriparesis. It shows that even with a 
very high risk for postoperative pulmonary complications, liver 
transplantation can be performed successfully with careful patient selection 
and effective respiratory care. © 2014 by Elsevier Inc. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  liver transplantation; 
EMTREE MEDICAL INDEX TERMS
  conference paper; priority journal; 
EMBASE CLASSIFICATIONS
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014293312
MEDLINE PMID
  24767403 (http://www.ncbi.nlm.nih.gov/pubmed/24767403)
PUI
  L372969700
DOI
  10.1016/j.transproceed.2013.11.131
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.transproceed.2013.11.131
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18732623&id=doi:10.1016%2Fj.transproceed.2013.11.131&atitle=Successful+liver+transplantation+in+a+patient+with+quadriparesis%3A+A+case+report&stitle=Transplant.+Proc.&title=Transplantation+Proceedings&volume=46&issue=3&spage=1001&epage=1002&aulast=Taesombat&aufirst=W.&auinit=W.&aufull=Taesombat+W.&coden=TRPPA&isbn=&pages=1001-1002&date=2014&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 445
TITLE
  Spinal cord injury (SCI) - Aspects of intensive medical care
ORIGINAL (NON-ENGLISH) TITLE
  Die Querschnittlähmung - Intensivmedizinische Aspekte
AUTHOR NAMES
  Leyk G.; Hirschfeld S.; Böthig R.; Willenbrock U.; Thietje R.; Lönnecker S.; Stuhr M.
AUTHOR ADDRESSES
  (Leyk G.; Willenbrock U.; Lönnecker S.; Stuhr M.) BG Unfallkrankenhaus 
Hamburg, Abteilung für Anästhesie, Intensiv- und Rettungsmedizin, Zentrum 
für Schmerztherapie, Germany.
(Hirschfeld S.; Thietje R.) BG Unfallkrankenhaus Hamburg, 
Querschnittgel-hmtenzentrum, Germany.
(Böthig R.) BG Unfallkrankenhaus Hamburg, Abteilung für Neuro- Urologie, 
Querschnittgel-hmtenzentrum, Germany.
AiP/IP ENTRY DATE
  2015-02-02
FULL RECORD ENTRY DATE
  2015-02-06
SOURCE
  Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie (2014) 49:9 
(506-513). Date of Publication: 2014
VOLUME
  49
ISSUE
  9
FIRST PAGE
  506
LAST PAGE
  513
DATE OF PUBLICATION
  2014
ISSN
  1439-1074 (electronic)
  0939-2661
BOOK PUBLISHER
  Georg Thieme Verlag, kunden.service@thieme.de
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; 
EMTREE MEDICAL INDEX TERMS
  article; cardiovascular system; human; incidence; intubation; patient monitoring; thromboembolism; tracheotomy; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  German
EMBASE ACCESSION NUMBER
  2015691733
MEDLINE PMID
  25238008 (http://www.ncbi.nlm.nih.gov/pubmed/25238008)
PUI
  L601522743
DOI
  10.1055/s-0034-1390052
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0034-1390052
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14391074&id=doi:10.1055%2Fs-0034-1390052&atitle=Spinal+cord+injury+%28SCI%29+-+Aspects+of+intensive+medical+care&stitle=Anasthesiol.+Intensivmed.+Notf.med.+Schmerzther.&title=Anasthesiologie+Intensivmedizin+Notfallmedizin+Schmerztherapie&volume=49&issue=9&spage=506&epage=513&aulast=Leyk&aufirst=Gesa&auinit=G.&aufull=Leyk+G.&coden=AISTE&isbn=&pages=506-513&date=2014&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 446
TITLE
  Airway management of fixed cervical spine undergoing transoral 
odontoidectomy: A novel technique
AUTHOR NAMES
  Hariharan U.; Ganguly N.; Sood J.; Shastri P.
AUTHOR ADDRESSES
  (Hariharan U., uma1708@gmail.com; Ganguly N.; Sood J.; Shastri P.) 
Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga 
Ram Hospital and GRIPMER, New Delhi, India.
CORRESPONDENCE ADDRESS
  U. Hariharan, Department of Anaesthesiology, Pain and Perioperative 
Medicine, Sir Ganga Ram Hospital and GRIPMER, New Delhi, India.
AiP/IP ENTRY DATE
  2015-04-21
FULL RECORD ENTRY DATE
  2015-04-24
SOURCE
  Current Medicine Research and Practice (2014) 4:4 (171-173). Date of 
Publication: 1 Jul 2014
VOLUME
  4
ISSUE
  4
FIRST PAGE
  171
LAST PAGE
  173
DATE OF PUBLICATION
  1 Jul 2014
ISSN
  2352-0817
BOOK PUBLISHER
  Reed Elsevier India Pvt. Ltd.
ABSTRACT
  Difficult airway can present in many ways: difficult mask ventilation, 
difficult oral or nasal intubation and/or difficult surgical airway. Either 
an oral or a nasal tube may be required, depending on the surgical exposure 
required, in complex head and neck surgeries. We present a unique case of 
nasal to orotracheal tube conversion with the help of a Ryles tube and 
rail-roading technique, in a setting of difficult airway. This case 
highlights that we have to keep our options open to innovative techniques 
for securing the desired airway in different circumstances.
EMTREE DRUG INDEX TERMS
  fentanyl (intravenous drug administration); lidocaine; midazolam (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  odontoid process; respiration control; spine stabilization; transoral odontoidectomy; 
EMTREE MEDICAL INDEX TERMS
  adult; airway edema; article; artificial ventilation; bronchoscope; case report; fiberoptic bronchoscopy; fibreoptic bronchoscope; fibreoptic intubation; human; intubation; male; nasal intubation; nasotracheal tube; quadriplegia; ryles tube; spasticity; tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015926429
PUI
  L603782003
DOI
  10.1016/j.cmrp.2014.07.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.cmrp.2014.07.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23520817&id=doi:10.1016%2Fj.cmrp.2014.07.001&atitle=Airway+management+of+fixed+cervical+spine+undergoing+transoral+odontoidectomy%3A+A+novel+technique&stitle=Curr.+Med.+Res.+Prac.&title=Current+Medicine+Research+and+Practice&volume=4&issue=4&spage=171&epage=173&aulast=Hariharan&aufirst=Uma&auinit=U.&aufull=Hariharan+U.&coden=&isbn=&pages=171-173&date=2014&auinit1=U&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 447
TITLE
  Early patency rate and fate of reattached intercostal arteries after repair 
of thoracoabdominal aortic aneurysms
AUTHOR NAMES
  Omura A.; Yamanaka K.; Miyahara S.; Sakamoto T.; Inoue T.; Okada K.; Okita Y.
AUTHOR ADDRESSES
  (Omura A.; Yamanaka K.; Miyahara S.; Sakamoto T.; Inoue T.; Okada K.; Okita 
Y., yokita@med.kobe-u.ac.jp) Department of Cardiovascular Surgery, Kobe 
University, Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 
Hyogo, Japan.
CORRESPONDENCE ADDRESS
  Y. Okita, Department of Cardiovascular Surgery, Kobe University, Graduate 
School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan. Email: 
yokita@med.kobe-u.ac.jp
AiP/IP ENTRY DATE
  2013-09-17
FULL RECORD ENTRY DATE
  2016-02-09
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2014) 147:6 (1-29). Date of 
Publication: 2014
VOLUME
  147
ISSUE
  6
FIRST PAGE
  1
LAST PAGE
  29
DATE OF PUBLICATION
  2014
ISSN
  1097-685X (electronic)
  0022-5223
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
ABSTRACT
  Objectives The present study analyzes the early patency of intercostal 
artery reconstruction, using graft interposition and aortic patch 
anastomosis, and determines the fate of reattached intercostal arteries 
after repair of thoracoabdominal aortic aneurysms. Methods We selected 115 
patients (mean age, 63 ± 15 years; range, 19-83 years; male, n = 83) treated 
by thoracoabdominal aortic aneurysm repair with 1 or more reconstructed 
intercostal arteries at the Kobe University Graduate School of Medicine 
between October 1999 and December 2012. The intercostal arteries were 
reconstructed using graft interposition (n = 66), aortic patch anastomosis 
(n = 42), or both (n = 7). Results The hospital mortality rate was 7.8% (n = 
9). Eleven patients (9.6%) developed spinal cord ischemic injury (permanent, 
n = 6, transient, n = 5). The average number of reconstructed intercostal 
arteries per patient was 3.0 ± 1.5 (1-7), and 345 intercostal arteries were 
reattached. The overall patency rate was 74.2% (256/345) and that of aortic 
patch anastomosis was significantly better than that of graft interposition 
(90.8% [109/120] vs 65.3% [147/225], P < .01), but significantly worse for 
patients with than without spinal cord ischemic injury (51.9% [14/27] vs 
76.1% [242/318], P = .01). There was no patch aneurysm in graft 
interposition during a mean of 49 ± 38 (range, 2-147) postoperative months, 
but aortic patch anastomosis including 4 intercostal arteries became dilated 
in 2 patients. Conclusions Aortic patch anastomosis might offer better 
patency rates and prevent spinal cord ischemic injury compared with graft 
interposition. Although aneurysmal changes in intercostal artery 
reconstructions are rare, large blocks of aortic wall reconstruction should 
be closely monitored.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artery; artery reconstruction; intercostal artery; spinal cord ischemia (complication); thoracoabdominal aorta aneurysm (surgery); vascular patency; 
EMTREE MEDICAL INDEX TERMS
  abdominal aorta; adult; aged; anastomosis; aortic patch anastomosis; aortic root; aortic surgery; article; ascending aorta; brain hemorrhage (complication); cardiovascular mortality; computer assisted tomography; dacron implant; descending aorta; endovascular aneurysm repair; female; follow up; graft interposition; graft patency; hemodialysis; human; major clinical study; male; mesenteric ischemia (complication); postoperative complication (complication); postoperative hemorrhage (complication); priority journal; respiratory failure (complication); risk factor; sepsis (complication); surgical mortality; surgical technique; survival rate; thoracic aorta; time to treatment; tracheostomy; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014782980
MEDLINE PMID
  24035377 (http://www.ncbi.nlm.nih.gov/pubmed/24035377)
PUI
  L52773370
DOI
  10.1016/j.jtcvs.2013.06.035
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2013.06.035
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1097685X&id=doi:10.1016%2Fj.jtcvs.2013.06.035&atitle=Early+patency+rate+and+fate+of+reattached+intercostal+arteries+after+repair+of+thoracoabdominal+aortic+aneurysms&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=147&issue=6&spage=1&epage=29&aulast=Omura&aufirst=Atsushi&auinit=A.&aufull=Omura+A.&coden=JTCSA&isbn=&pages=1-29&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 448
TITLE
  Expert’s comment concerning Grand Rounds case entitled: “Trans-oral approach 
for the management of a C2 neuroblastoma” (K. M. I. Salem, J. Visser, and N. 
A. Quraishi)
AUTHOR NAMES
  Choi D.
AUTHOR ADDRESSES
  (Choi D., david.choi@uclh.nhs.uk) Department of Neurosurgery, National 
Hospital for Neurology and Neurosurgery, Queen Square, London, United 
Kingdom.
CORRESPONDENCE ADDRESS
  D. Choi, Department of Neurosurgery, National Hospital for Neurology and 
Neurosurgery, Queen Square, London, United Kingdom.
AiP/IP ENTRY DATE
  2014-12-01
FULL RECORD ENTRY DATE
  2015-08-20
SOURCE
  European Spine Journal (2014) 24:1 (177-179). Date of Publication: 2014
VOLUME
  24
ISSUE
  1
FIRST PAGE
  177
LAST PAGE
  179
DATE OF PUBLICATION
  2014
ISSN
  1432-0932 (electronic)
  0940-6719
BOOK PUBLISHER
  Springer Verlag, service@springer.de
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  c2 neuroblastoma (radiotherapy, surgery); neuroblastoma (radiotherapy, surgery); second cervical vertebra; surgical technique; transoral surgical technique; 
EMTREE MEDICAL INDEX TERMS
  article; cancer radiotherapy; cranial nerve paralysis; fatigue; human; nasotracheal tube; neuroimaging; nuclear magnetic resonance imaging; priority journal; spinal cord compression; tracheostomy; X ray; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2014920528
MEDLINE PMID
  25416168 (http://www.ncbi.nlm.nih.gov/pubmed/25416168)
PUI
  L600545364
DOI
  10.1007/s00586-014-3662-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-014-3662-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14320932&id=doi:10.1007%2Fs00586-014-3662-7&atitle=Expert%E2%80%99s+comment+concerning+Grand+Rounds+case+entitled%3A+%E2%80%9CTrans-oral+approach+for+the+management+of+a+C2+neuroblastoma%E2%80%9D+%28K.+M.+I.+Salem%2C+J.+Visser%2C+and+N.+A.+Quraishi%29&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=24&issue=1&spage=177&epage=179&aulast=Choi&aufirst=David&auinit=D.&aufull=Choi+D.&coden=ESJOE&isbn=&pages=177-179&date=2014&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 449
TITLE
  Aggresome-autophagy involvement in a sarcopenic patient with rigid spine 
syndrome and a p.C150R mutation in FHL1 gene
AUTHOR NAMES
  Sabatelli P.; Castagnaro S.; Tagliavini F.; Chrisam M.; Sardone F.; Demay L.; Richard P.; Santi S.; Maraldi N.M.; Merlini L.; Sandri M.; Bonaldo P.
AUTHOR ADDRESSES
  (Sabatelli P.; Tagliavini F.; Sardone F.; Santi S.; Maraldi N.M.) Institute 
of Molecular Genetics, CNR-National Research Council of Italy, Bologna, 
Italy.
(Sabatelli P.; Tagliavini F.; Sardone F.; Santi S.; Merlini L.) SC 
Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, 
Bologna, Italy.
(Castagnaro S.; Chrisam M.; Bonaldo P., bonaldo@bio.unipd.it) Department of 
Molecular Medicine, University of Padova, Padova, Italy.
(Demay L.) UF Cardiogénétique et Myogénétique, Service de Biochimie 
Métabolique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
(Richard P.) UF Cardiogénétique et Myogénétique, Centre de Génétique, 
Hôpitaux Universitaires de la Pitié Salpêtrière, Paris, France.
(Sandri M.) Dulbecco Telethon Institute, Venetian Institute of Molecular 
Medicine, Padova, Italy.
(Sandri M.) Department of Biomedical Science, University of Padova, Padova, 
Italy.
CORRESPONDENCE ADDRESS
  P. Bonaldo, Department of Molecular Medicine, University of Padova, Via U. 
Bassi 58/B, Padova I-35131, Italy. Email: bonaldo@bio.unipd.it
AiP/IP ENTRY DATE
  2014-08-29
FULL RECORD ENTRY DATE
  2014-09-04
SOURCE
  Frontiers in Aging Neuroscience (2014) 6:AUG Article Number: Article 215. 
Date of Publication: 2014
VOLUME
  6
ISSUE
  AUG
DATE OF PUBLICATION
  2014
ISSN
  1663-4365 (electronic)
BOOK PUBLISHER
  Frontiers Research Foundation, info@frontiersin.org
ABSTRACT
  The four-and-half LIM domain protein 1 (FHL1) is highly expressed in 
skeletal and cardiac muscle. Mutations of the FHL1 gene have been associated 
with diverse chronic myopathies including reducing body myopathy, rigid 
spine syndrome (RSS), and Emery-Dreifuss muscular dystrophy. We investigated 
a family with a mutation (p.C150R) in the second LIM domain of FHL1. In this 
family, a brother and a sister were affected by RSS, and their mother had 
mild lower limbs weakness. The 34-year-old female had an early and 
progressive rigidity of the cervical spine and severe respiratory 
insufficiency. Muscle mass evaluated by DXA was markedly reduced, while fat 
mass was increased to 40%. CT scan showed an almost complete substitution of 
muscle by fibro-adipose tissue. Muscle biopsy showed accumulation of FHL1 
throughout the cytoplasm and around myonuclei into multiprotein aggregates 
with aggresome/autophagy features as indicated by ubiquitin, p62, and LC3 
labeling. DNA deposits, not associated with nuclear lamina components and 
histones, were also detected in the aggregates, suggesting nuclear 
degradation. Ultrastructural analysis showed the presence of dysmorphic 
nuclei, accumulation of tubulofilamentous and granular material, and 
perinuclear accumulation of autophagic vacuoles. These data point to 
involvement of the aggresome-autophagy pathway in the pathophysiological 
mechanism underlying the muscle pathology of FHL1 C150R mutation. © 2014 
Sabatelli, Castagnaro, Tagliavini, Chrisam, Sardone, Demay, Richard, Santi, 
Maraldi, Merlini, Sandri and Bonaldo.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  four and half LIM domain protein 1 (endogenous compound); LIM protein (endogenous compound); 
EMTREE DRUG INDEX TERMS
  alpha crystallin (endogenous compound); beta crystallin (endogenous compound); collagen type 6 (endogenous compound); desmin (endogenous compound); glucose regulated protein 78 (endogenous compound); sequestosome 1 (endogenous compound); ubiquitin (endogenous compound); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aggresome; autophagy; missense mutation; rigid spine syndrome; sarcopenia; spine disease; 
EMTREE MEDICAL INDEX TERMS
  adult; amino acid substitution; article; artificial ventilation; body composition; body fat; case report; computer assisted tomography; contracture; cytoplasm; endomysium; exon; fat mass; female; forced vital capacity; human; joint limitation; lean body weight; limb weakness; male; muscle atrophy; muscle biopsy; muscle mass; muscle rigidity; nuclear lamina; perimysium; phenotype; protein aggregation; respiratory failure; sarcoplasmic reticulum; tracheostomy; underweight; upregulation; 
CAS REGISTRY NUMBERS
  ubiquitin (60267-61-0)
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014554990
PUI
  L373791639
DOI
  10.3389/fnagi.2014.00215
FULL TEXT LINK
  http://dx.doi.org/10.3389/fnagi.2014.00215
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16634365&id=doi:10.3389%2Ffnagi.2014.00215&atitle=Aggresome-autophagy+involvement+in+a+sarcopenic+patient+with+rigid+spine+syndrome+and+a+p.C150R+mutation+in+FHL1+gene&stitle=Front.+Aging+Neurosci.&title=Frontiers+in+Aging+Neuroscience&volume=6&issue=AUG&spage=&epage=&aulast=Sabatelli&aufirst=Patrizia&auinit=P.&aufull=Sabatelli+P.&coden=&isbn=&pages=-&date=2014&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 450
TITLE
  Prevalence of difficult airway predictors in cases of failed prehospital 
endotracheal intubation
AUTHOR NAMES
  Gaither J.B.; Spaite D.W.; Stolz U.; Ennis J.; Mosier J.; Sakles J.J.
AUTHOR ADDRESSES
  (Gaither J.B.; Spaite D.W.; Stolz U.; Ennis J.; Mosier J.; Sakles J.J.) 
Arizona Emergency Medicine Research Center, Department of Emergency 
Medicine, University of Arizona College of Medicine, 3950 S. Country Club 
Road, #2254, Tucson, AZ 85714, United States.
CORRESPONDENCE ADDRESS
  J.B. Gaither, Arizona Emergency Medicine Research Center, Department of 
Emergency Medicine, University of Arizona College of Medicine, 3950 S. 
Country Club Road, #2254, Tucson, AZ 85714, United States.
AiP/IP ENTRY DATE
  2014-06-09
FULL RECORD ENTRY DATE
  2014-09-10
SOURCE
  Journal of Emergency Medicine (2014) 47:3 (294-300). Date of Publication: 
September 2014
VOLUME
  47
ISSUE
  3
FIRST PAGE
  294
LAST PAGE
  300
DATE OF PUBLICATION
  September 2014
ISSN
  0736-4679
BOOK PUBLISHER
  Elsevier USA
ABSTRACT
  Background Difficult airway predictors (DAPs) are associated with failed 
endotracheal intubation (ETI) in the emergency department (ED). However, 
little is known about the relationship between DAPs and failed prehospital 
ETI. Objective Our aim was to determine the prevalence of common DAPs among 
failed prehospital intubations. Methods We reviewed a quality-improvement 
database, including all cases of ETI in a single ED, over 3 years. Failed 
prehospital (FP) ETI was defined as a case brought to the ED after attempted 
prehospital ETI, but bag-valve-mask ventilation, need for a rescue airway 
(supraglottic device, cricothyrotomy, etc.), or esophageal intubation was 
discovered at the ED. Physicians performing ETI evaluated each case for the 
presence of DAPs, including blood/emesis, facial/neck trauma, airway edema, 
spinal immobilization, short neck, and tongue enlargement. Results There 
were a total of 1377 ED ETIs and 161 had an FP-ETI (11.8%). Prevalence of 
DAPs in cases with FP-ETI was obesity 13.0%, large tongue 18.0%, short neck 
13%, small mandible 4.3%, cervical immobility 49.7%, blood in airway 57.8%, 
vomitus in airway 23.0%, airway edema 12.4%, and facial or neck trauma 
32.9%. The number of cases with FP-ETI and 0, 1, 2, 3, or 4 or more DAPs per 
case was 22 (13.6%), 43 (26.7%), 23 (24.3%), 42 (26.1%), and 31 (19.3%), 
respectively. Conclusions DAPs are common in cases of FP-ETI. Some of these 
factors may be associated with FP-ETI. Additional study is needed to 
determine if DAPs can be used to identify patients that are difficult to 
intubate in the field. © 2014 Elsevier Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  difficult airway predictor; emergency care; endotracheal intubation; failed prehospital endotracheal intubation; prediction; respiration control; respiratory tract parameters; treatment failure; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; controlled study; emergency ward; esophagus intubation; face injury; female; human; immobility; immobilization; lung edema; major clinical study; male; manual emergency ventilator; neck injury; obesity; prevalence; priority journal; retrospective study; supraglottic airway device; survival prediction; total quality management; tracheotomy; vomiting; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014566531
MEDLINE PMID
  24906900 (http://www.ncbi.nlm.nih.gov/pubmed/24906900)
PUI
  L53154049
DOI
  10.1016/j.jemermed.2014.04.021
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jemermed.2014.04.021
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07364679&id=doi:10.1016%2Fj.jemermed.2014.04.021&atitle=Prevalence+of+difficult+airway+predictors+in+cases+of+failed+prehospital+endotracheal+intubation&stitle=J.+Emerg.+Med.&title=Journal+of+Emergency+Medicine&volume=47&issue=3&spage=294&epage=300&aulast=Gaither&aufirst=Joshua+B.&auinit=J.B.&aufull=Gaither+J.B.&coden=JEMMD&isbn=&pages=294-300&date=2014&auinit1=J&auinitm=B
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 451
TITLE
  Cuff deflation: rehabilitation in critical care.
AUTHOR NAMES
  Bach J.R.; Gonçalves M.R.; Rodriguez P.L.; Saporito L.; Soares L.
AUTHOR ADDRESSES
  (Bach J.R.) From the Department of Physical Medicine and Rehabilitation, 
Rutgers New Jersey Medical School, Newark, New Jersey (JRB, L. Saporito); 
Department of Pulmonology, University Hospital of São João, Faculty of 
Medicine, University of Porto, Porto, Portugal (MRG, L. Soares); and 
Departamento de Neumología, Hospital Clinico Universitario San Joan 
D'Alacant, Alicante, Spain (PLR).
(Gonçalves M.R.; Rodriguez P.L.; Saporito L.; Soares L.)
CORRESPONDENCE ADDRESS
  J.R. Bach,
FULL RECORD ENTRY DATE
  2014-09-19
SOURCE
  American journal of physical medicine & rehabilitation / Association of 
Academic Physiatrists (2014) 93:8 (719-723). Date of Publication: Aug 2014
VOLUME
  93
ISSUE
  8
FIRST PAGE
  719
LAST PAGE
  723
DATE OF PUBLICATION
  Aug 2014
ISSN
  1537-7385 (electronic)
ABSTRACT
  This is a case series of rehabilitation failures that resulted in severe 
reactive depression from patients unnecessarily bereft of verbal 
communication by being left to breathe or be ventilated via tracheostomy 
tubes, with or without inflated cuffs, for months to years.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adjustment disorder (etiology); muscular dystrophy (rehabilitation); noninvasive ventilation (adverse drug reaction); spinal cord injury (rehabilitation); tracheostomy (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; human; intensive care; male; methodology; middle aged; speech; young adult; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  24879555 (http://www.ncbi.nlm.nih.gov/pubmed/24879555)
PUI
  L373919225
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15377385&id=doi:&atitle=Cuff+deflation%3A+rehabilitation+in+critical+care.&stitle=Am+J+Phys+Med+Rehabil&title=American+journal+of+physical+medicine+%26+rehabilitation+%2F+Association+of+Academic+Physiatrists&volume=93&issue=8&spage=719&epage=723&aulast=Bach&aufirst=John+R&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=719-723&date=2014&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2014 Medline is the source for the citation and abstract of this 
record.

RECORD 452
TITLE
  Multidisciplinary interventions in motor neuron disease
AUTHOR NAMES
  Williams U.E.; Philip-Ephraim E.E.; Oparah S.K.
AUTHOR ADDRESSES
  (Williams U.E., williamsuduak@yahoo.co.uk; Philip-Ephraim E.E., 
nneninge@yahoo.com; Oparah S.K., sidkele@yahoo.com) Internal Medicine 
Department, University of Calabar, Calabar, Cross River State, Nigeria.
CORRESPONDENCE ADDRESS
  U.E. Williams, Internal Medicine Department, University of Calabar, Calabar, 
Cross River State, Nigeria.
AiP/IP ENTRY DATE
  2014-12-25
FULL RECORD ENTRY DATE
  2015-01-05
SOURCE
  Journal of Neurodegenerative Diseases (2014) 2014 Article Number: 435164. 
Date of Publication: 2014
VOLUME
  2014
DATE OF PUBLICATION
  2014
ISSN
  2090-8601 (electronic)
  2090-858X
BOOK PUBLISHER
  Hindawi Publishing Corporation, 410 Park Avenue, 15th Floor, 287 pmb, New 
York, United States.
ABSTRACT
  Motor neuron disease is a neurodegenerative disease characterized by loss of 
upper motor neuron in the motor cortex and lower motor neurons in the brain 
stem and spinal cord. Death occurs 2-4 years after the onset of the disease. 
A complex interplay of cellular processes such as mitochondrial dysfunction, 
oxidative stress, excitotoxicity, and impaired axonal transport are proposed 
pathogenetic processes underlying neuronal cell loss. Currently evidence 
exists for the use of riluzole as a disease modifying drug; 
multidisciplinary team care approach to patient management; noninvasive 
ventilation for respiratory management; botulinum toxin B for sialorrhoea 
treatment; palliative care throughout the course of the disease; and 
Modafinil use for fatigue treatment. Further research is needed in 
management of dysphagia, bronchial secretion, pseudobulbar affect, 
spasticity, cramps, insomnia, cognitive impairment, and communication in 
motor neuron disease.
EMTREE DRUG INDEX TERMS
  acetylcysteine; amitriptyline (drug therapy); atropine (drug therapy); baclofen (drug therapy); botulinum toxin B (drug therapy); carbamazepine (drug therapy); ciliary neurotrophic factor (drug therapy); citalopram; dantrolene (drug therapy); dextromethorphan plus quinidine; diazepam (drug therapy); etiracetam (drug therapy); modafinil (drug therapy); phenytoin (drug therapy); quinidine; quinine sulfate (drug therapy); recombinant somatomedin C (drug therapy); riluzole (drug therapy); tetrazepam (drug therapy); tizanidine (drug therapy); verapamil (drug therapy); zolpidem (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  medical care; motor neuron disease (drug therapy, drug therapy, therapy); 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; bronchus secretion; cognitive defect; cost effectiveness analysis; disability; disease course; dysphagia; early diagnosis; electrostimulation; fatigue (drug therapy); health care cost; hospitalization; human; hypersalivation (drug therapy); insomnia (drug therapy); interpersonal communication; living will; medical specialist; meta analysis (topic); muscle cramp (drug therapy); neuroprotection; noninvasive ventilation; nutritional support; palliative therapy; parenteral nutrition; patient care; patient selection; physiotherapy; quality of life; review; spasticity (drug therapy, therapy); survival time; telemonitoring; terminal care; tracheostomy; 
CAS REGISTRY NUMBERS
  acetylcysteine (616-91-1)
  amitriptyline (50-48-6, 549-18-8)
  atropine (51-55-8, 55-48-1)
  baclofen (1134-47-0)
  botulinum toxin B (93384-44-2)
  carbamazepine (298-46-4, 8047-84-5)
  citalopram (59729-33-8)
  dantrolene (14663-23-1, 7261-97-4)
  diazepam (439-14-5)
  etiracetam (102767-28-2, 33996-58-6)
  modafinil (68693-11-8)
  phenytoin (57-41-0, 630-93-3)
  quinidine (56-54-2)
  quinine sulfate (804-63-7)
  recombinant somatomedin C (68562-41-4)
  riluzole (1744-22-5)
  tetrazepam (10379-14-3)
  tizanidine (51322-75-9, 64461-82-1)
  verapamil (152-11-4, 52-53-9)
  zolpidem (82626-48-0)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014613998
PUI
  L600647755
DOI
  10.1155/2014/435164
FULL TEXT LINK
  http://dx.doi.org/10.1155/2014/435164
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20908601&id=doi:10.1155%2F2014%2F435164&atitle=Multidisciplinary+interventions+in+motor+neuron+disease&stitle=J.+Neurodegenerative+Dis.&title=Journal+of+Neurodegenerative+Diseases&volume=2014&issue=&spage=&epage=&aulast=Williams&aufirst=U.E.&auinit=U.E.&aufull=Williams+U.E.&coden=&isbn=&pages=-&date=2014&auinit1=U&auinitm=E
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 453
TITLE
  Progressive dysautonomia in two patients with xeroderma pigmentosum group A
AUTHOR NAMES
  Kobayashi O.; Miyahara H.; Abe N.; Goto C.; Okanari K.; Akiyoshi K.; Korematsu S.; Izumi T.
AUTHOR ADDRESSES
  (Kobayashi O., o-kobayashi@oita-u.ac.jp; Miyahara H.; Abe N.; Goto C.; 
Okanari K.; Akiyoshi K.; Korematsu S.; Izumi T.) Department of Pediatrics 
and Child Neurology, Oita University, Faculty of Medicine, 1-1 Idaigaoka, 
Hasama; Yufu; Oita 879-5593, Japan.
CORRESPONDENCE ADDRESS
  O. Kobayashi, Department of Pediatrics and Child Neurology, Oita University, 
Faculty of Medicine, 1-1 Idaigaoka, Hasama; Yufu; Oita 879-5593, Japan. 
Email: o-kobayashi@oita-u.ac.jp
AiP/IP ENTRY DATE
  2014-05-29
FULL RECORD ENTRY DATE
  2014-06-10
SOURCE
  Pediatric Neurology (2014) 50:6 (619-621). Date of Publication: June 2014
VOLUME
  50
ISSUE
  6
FIRST PAGE
  619
LAST PAGE
  621
DATE OF PUBLICATION
  June 2014
ISSN
  1873-5150 (electronic)
  0887-8994
BOOK PUBLISHER
  Elsevier Inc., usjcs@elsevier.com
ABSTRACT
  Background: Xeroderma pigmentosum group A (XPA) is a rare 
autosomal-recessive disorder caused by a defect in nucleotide excision 
repair. Progressive dysautonomia in patients with XPA is rarely described. 
Patients Two juvenile male patients with XPA suffered from dysphagia, sleep 
interruption, and dysuria from the age of 10 to 19 years, successively. 
These autonomic symptoms might have been caused by progressive descending 
degeneration of cranial nerves IX and X and the sacral parasympathetic 
nerve, including Onuf's nucleus. One patient died from sudden 
cardiopulmonary arrest during postural change and tracheal suction. Results 
Heart rate variability analyses of these patients revealed parasympathetic 
dysautonomia, based on decreased high-frequency values. Conclusions The 
insidiously progressive dysautonomia in these two patients with XPA 
suggested progressive descending degeneration extending from the medulla 
oblongata to the sacral spinal cord, which is an ominous sign of end-stage 
disease and a risk factor of sudden death attributable to XPA. © 2014 
Elsevier Inc. All rights reserved.
EMTREE DRUG INDEX TERMS
  proton pump inhibitor (drug therapy, oral drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysautonomia; xeroderma pigmentosum; xeroderma pigmentosum group a; 
EMTREE MEDICAL INDEX TERMS
  adult; article; aspiration; autonomic nervous system; bladder distension; body position; brain; brain atrophy; brain stem; cardiopulmonary arrest; cardiovascular mortality; case report; cause of death; cerebellar ataxia; cerebellum; corpus callosum; coughing (drug therapy); cranial nerve; disease course; disease exacerbation; dysphagia; dysuria; gait disorder; gait disturbance; gastroesophageal reflux; gene mutation; heart rate; heart rate variability; hiatus hernia; hospitalization; human; intellectual impairment; male; nerve degeneration; neurogenic bladder; nuclear magnetic resonance imaging; parasympathetic function; parasympathetic nerve; perception deafness; peripheral neuropathy; priority journal; quadriplegia; residual urine; restriction fragment length polymorphism; sleep disorder (drug therapy); sleep interruption (drug therapy); sleep interruption (drug therapy); spinal cord; stridor; sudden cardiac death; sympathetic function; tracheotomy; young adult; 
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014346503
MEDLINE PMID
  24679606 (http://www.ncbi.nlm.nih.gov/pubmed/24679606)
PUI
  L373122979
DOI
  10.1016/j.pediatrneurol.2014.01.026
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pediatrneurol.2014.01.026
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18735150&id=doi:10.1016%2Fj.pediatrneurol.2014.01.026&atitle=Progressive+dysautonomia+in+two+patients+with+xeroderma+pigmentosum+group+A&stitle=Pediatr.+Neurol.&title=Pediatric+Neurology&volume=50&issue=6&spage=619&epage=621&aulast=Kobayashi&aufirst=Osamu&auinit=O.&aufull=Kobayashi+O.&coden=PNEUE&isbn=&pages=619-621&date=2014&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 454
TITLE
  Observational study of spinal muscular atrophy type I and implications for 
clinical trials
AUTHOR NAMES
  Finkel R.S.; McDermott M.P.; Kaufmann P.; Darras B.T.; Chung W.K.; Sproule D.M.; Kang P.B.; Reghan Foley A.; Yang M.L.; Martens W.B.; Oskoui M.; Glanzman A.M.; Flickinger J.; Montes J.; Dunaway S.; O'Hagen J.; Quigley J.; Riley S.; Benton M.; Ryan P.A.; Montgomery M.; Marra J.; Gooch C.; De Vivo D.C.
AUTHOR ADDRESSES
  (Reghan Foley A.; Yang M.L.) Departments of Neurology, Children's Hospital 
of Philadelphia, United States.
(Reghan Foley A.; Yang M.L.; Benton M.) Departments of Pediatrics, 
Children's Hospital of Philadelphia, United States.
(Glanzman A.M.; Flickinger J.) Physical Therapy, Children's Hospital of 
Philadelphia, United States.
(Reghan Foley A.; Yang M.L.) Perelman School of Medicine at University of 
Pennsylvania, Children's Hospital of Philadelphia, United States.
(McDermott M.P.) Departments of Biostatistics and Computational Biology, 
University of Rochester, United States.
(McDermott M.P.; Martens W.B.) Departments of Neurology, University of 
Rochester, United States.
(Kaufmann P.; Sproule D.M.; Montes J.; Dunaway S.; O'Hagen J.; Montgomery 
M.; Marra J.; De Vivo D.C.) Departments of Neurology, Columbia University, 
New York, United States.
(Chung W.K.; Sproule D.M.; Ryan P.A.; De Vivo D.C.) Departments of 
Pediatrics, Columbia University, New York, United States.
(Darras B.T.) Departments of Neurology, Harvard Medical School, Boston 
Children's Hospital, Boston, United States.
(Quigley J.; Riley S.) Departments of Physical Therapy, Harvard Medical 
School, Boston Children's Hospital, Boston, United States.
(Gooch C.) Department of Neurology, University of South Florida, Tampa, 
United States.
(Oskoui M.) Departments of Neurology and Neurosurgery, McGill University, 
Montreal, Canada.
(Oskoui M.) Departments of Pediatrics, McGill University, Montreal, Canada.
(Finkel R.S.) Division of Neurology, Nemours Children's Hospital, Orlando, 
United States.
(Kang P.B.) Division of Pediatric Neurology, University of Florida College 
of Medicine, Gainesville, United States.
AiP/IP ENTRY DATE
  2015-04-06
FULL RECORD ENTRY DATE
  2015-04-13
SOURCE
  Neurology (2014) 83:9 (810-817). Date of Publication: 2014
VOLUME
  83
ISSUE
  9
FIRST PAGE
  810
LAST PAGE
  817
DATE OF PUBLICATION
  2014
ISSN
  1526-632X (electronic)
  0028-3878
BOOK PUBLISHER
  Lippincott Williams and Wilkins, LRorders@phl.lrpub.com
ABSTRACT
  Objectives: Prospective cohort study to characterize the clinical features 
and course of spinal muscular atrophy type I (SMA-I). Methods: Patients were 
enrolled at 3 study sites and followed for up to 36 months with serial 
clinical, motor function, laboratory, and electrophysiologic outcome 
assessments. Intervention was determined by published standard of care 
guidelines. Palliative care options were offered. Results: Thirty-four of 54 
eligible subjects with SMA-I (63%) enrolled and 50% of these completed at 
least 12 months of follow-up. The median age at reaching the combined 
endpoint of death or requiring at least 16 hours/day of ventilation support 
was 13.5 months (interquartile range 8.1-22.0 months). Requirement for 
nutritional support preceded that for ventilation support. The distribution 
of age at reaching the combined endpoint was similar for subjects with SMA-I 
who had symptom onset before 3 months and after 3 months of age (p 5 0.58). 
Having 2 SMN2 copies was associated with greater morbidity and mortality 
than having 3 copies. Baseline electrophysiologic measures indicated 
substantial motor neuron loss. By comparison, subjects with SMA-II who lost 
sitting ability (n510) had higher motor function, motor unit number estimate 
and compound motor action potential, longer survival, and later age when 
feeding or ventilation support was required. The mean rate of decline in The 
Children's Hospital of Philadelphia Infant Test for Neuromuscular Disorders 
motor function scale was 1.27 points/year (95% confidence interval 
0.21-2.33, p 5 0.02). Conclusions: Infants with SMA-I can be effectively 
enrolled and retained in a 12-month natural history study until a majority 
reach the combined endpoint. These outcome data can be used for clinical 
trial design.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  clinical trial (topic); spinal muscular atrophy; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; airway obstruction; article; child; chronic patient; clinical feature; female; heart arrest; human; lung infection; major clinical study; male; mortality; motor performance; noninvasive ventilation; nutritional support; observational study; priority journal; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015875498
MEDLINE PMID
  25080519 (http://www.ncbi.nlm.nih.gov/pubmed/25080519)
PUI
  L603499677
DOI
  10.1212/WNL.0000000000000741 1526-632X
FULL TEXT LINK
  http://dx.doi.org/10.1212/WNL.0000000000000741 1526-632X
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1526632X&id=doi:10.1212%2FWNL.0000000000000741+1526-632X&atitle=Observational+study+of+spinal+muscular+atrophy+type+I+and+implications+for+clinical+trials&stitle=Neurology&title=Neurology&volume=83&issue=9&spage=810&epage=817&aulast=Reghan+Foley&aufirst=&auinit=A.&aufull=Reghan+Foley+A.&coden=NEURA&isbn=&pages=810-817&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 455
TITLE
  Neuroblastoma with symptomatic epidural compression in the infant: The AIEOP 
experience
AUTHOR NAMES
  De Bernardi B.; Quaglietta L.; Haupt R.; Castellano A.; Tirtei E.; Luksch R.; Mastrangelo S.; Viscardi E.; Indolfi P.; Cellini M.; Tamburini A.; Erminio G.; Gandolfo C.; Sorrentino S.; Vetrella S.; Gigliotti A.R.
AUTHOR ADDRESSES
  (De Bernardi B., brunodebernardi@ospedale-gaslini.ge.it; Sorrentino S.) 
Department of Hematology-Oncology, Istituto Giannina Gaslini, Genova, Italy.
(Quaglietta L.; Vetrella S.) Department of Oncology, AORN 
Santobono-Pausilipon, Napoli, Italy.
(Haupt R.; Erminio G.; Gigliotti A.R.) Epidemiology and Biostatistics 
Section, Istituto Giannina Gaslini, Genova, Italy.
(Castellano A.) Department of Hematology-Oncology, Ospedale Pediatrico 
Bambino Gesù, Roma, Italy.
(Tirtei E.) Department of Onco-Hematology, Ospedale Pediatrico Regina 
Margherita, Torino, Italy.
(Luksch R.) Department of Pediatric Oncology, Fondazione IRCCS Istituto 
Nazionale dei Tumori, Milano, Italy.
(Mastrangelo S.) Division of Pediatric Oncology, Università Cattolica di 
Roma-Ospedale A. Gemelli, Roma, Italy.
(Viscardi E.) Division of Pediatric Oncology, Università di Padova, Padova, 
Italy.
(Indolfi P.) Pediatric Oncology Unit, Department of Pediatrics, II 
Università di Napoli, Napoli, Italy.
(Cellini M.) Division of Pediatric Oncology, Azienda 
Ospedaliero-Universitaria di Modena, Modena, Italy.
(Tamburini A.) Pediatric Oncology Unit, Ospedale Pediatrico Meyer, Firenze, 
Italy.
(Gandolfo C.) Service of Pediatric Neuroradiology, Istituto Giannina 
Gaslini, Genova, Italy.
CORRESPONDENCE ADDRESS
  B. De Bernardi, Department of Hematology-Oncology, Istituto Giannina 
Gaslini, Via Gerolamo Gaslini, 5, 16147 Genova, Italy. Email: 
brunodebernardi@ospedale-gaslini.ge.it
AiP/IP ENTRY DATE
  2014-06-18
FULL RECORD ENTRY DATE
  2014-06-24
SOURCE
  Pediatric Blood and Cancer (2014) 61:8 (1369-1375). Date of Publication: 
2014
VOLUME
  61
ISSUE
  8
FIRST PAGE
  1369
LAST PAGE
  1375
DATE OF PUBLICATION
  2014
ISSN
  1545-5017 (electronic)
  1545-5009
BOOK PUBLISHER
  Wiley-Liss Inc., info@wiley.com
ABSTRACT
  Background: Symptoms of epidural compression (SEC) in children with 
neuroblastoma (particularly infants) may be misinterpreted, leading to delay 
in diagnosis. Patients and Methods: Clinical, imaging and follow-up data of 
34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at 
Italian AIEOP centers were retrieved and reviewed. Results: Median age at 
initial SEC was 104 days (IQR 47-234). Main symptoms included motor deficit 
(85.3%), pain (38.2%), bladder and bowel dysfunctions (20.6% each). In the 
symptom-diagnosis interval (S-DI) (median, 12 days; IQR 7-34), the frequency 
of grade 3 motor deficit increased from 11.8% to 44.1% and that of bladder 
dysfunction from 20.6% to 32.4%. S-DI was significantly longer (P=0.011) for 
patients developing grade 3 motor deficit. First treatment of SEC was 
neurosurgery in 14 patients, and chemotherapy in 20. SEC regressed in 11 
patients (32.3%), improved in 9 (26.5%), and remained stable in 14 (41.2%), 
without treatment-related differences. Median follow-up was 82 months. At 
last visit, 11 patients (32.3%) were sequelae-free while 23 (67.7%) had 
sequelae, including motor deficit (55.9%), bladder (50.0%) and bowel 
dysfunctions (28.4%), and spinal abnormalities (38.2%). Sequelae were rated 
severe in 50% of patients. Severe sequelae scores were more frequent in 
patients presenting with spinal canal invasion >66% (P=0.039) and grade 3 
motor deficit (P=0.084). Conclusions: Both neurosurgery and chemotherapy 
provide unsatisfactory results once paraplegia has been established. 
Sequelae developed in the majority of study patients and were severe in a 
half of them. Greater awareness by parents and physicians regarding SEC is 
warranted. © 2014 Wiley Periodicals, Inc.
EMTREE DRUG INDEX TERMS
  carboplatin (drug combination, drug therapy); cyclophosphamide (drug combination, drug therapy); doxorubicin (drug combination, drug therapy); etoposide (drug combination, drug therapy); vincristine (drug combination, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  infant disease (drug therapy, drug therapy, surgery); neuroblastoma (drug therapy, drug therapy, surgery); spinal cord compression (surgery); symptomatic epidural compression (surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal distension; article; bladder dysfunction; cancer combination chemotherapy; cancer grading; cancer survival; clinical article; enteropathy; event free survival; female; follow up; Horner syndrome; human; infant; laminectomy; male; motor dysfunction; multicenter study (topic); neurosurgery; overall survival; pain; priority journal; respiratory distress; tracheostomy; tumor invasion; urine incontinence; urine retention; vertebral canal; 
CAS REGISTRY NUMBERS
  carboplatin (41575-94-4)
  cyclophosphamide (50-18-0)
  doxorubicin (23214-92-8, 25316-40-9)
  etoposide (33419-42-0)
  vincristine (57-22-7)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014389267
MEDLINE PMID
  24619960 (http://www.ncbi.nlm.nih.gov/pubmed/24619960)
PUI
  L373252855
DOI
  10.1002/pbc.25028
FULL TEXT LINK
  http://dx.doi.org/10.1002/pbc.25028
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15455017&id=doi:10.1002%2Fpbc.25028&atitle=Neuroblastoma+with+symptomatic+epidural+compression+in+the+infant%3A+The+AIEOP+experience&stitle=Pediatr.+Blood+Cancer&title=Pediatric+Blood+and+Cancer&volume=61&issue=8&spage=1369&epage=1375&aulast=De+Bernardi&aufirst=Bruno&auinit=B.&aufull=De+Bernardi+B.&coden=PBCEA&isbn=&pages=1369-1375&date=2014&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 456
TITLE
  Use of airtraq optical laryngoscope for naso-tracheal intubation in 
anaesthetized patients
AUTHOR NAMES
  Malik S.; Jamil S.N.; Malik S.; Varshney R.
AUTHOR ADDRESSES
  (Malik S., dr.malik_sunny@yahoo.co.in) Department of Anaesthesia, Pandit 
Madan Mohan Malviya Hospital, New Delhi, U.P., India.
(Jamil S.N.) Department of Anaesthesia, J.N. Medical College, A.M.U., 
Aligarh, India.
(Malik S.) Department of Anaesthesia, ESI Hospital, New Delhi, India.
(Varshney R.) Department of Anaesthesia, Teerthanker Mahaveer Medical 
College and Research Centre, Moradabad, U.P., India.
CORRESPONDENCE ADDRESS
  S. Malik, Department of Anaesthesia, Pandit Madan Mohan Malviya Hospital, 
New Delhi, India.
AiP/IP ENTRY DATE
  2015-06-18
FULL RECORD ENTRY DATE
  2015-06-23
SOURCE
  Acta Medica International (2014) 1:1 (41-42). Date of Publication: 2014
VOLUME
  1
ISSUE
  1
FIRST PAGE
  41
LAST PAGE
  42
DATE OF PUBLICATION
  2014
ISSN
  2349-0896 (electronic)
  2349-0578
BOOK PUBLISHER
  Teerthanker Mahaveer University, apadu@yahoo.in
ABSTRACT
  Reported is a case of successful Nasotracheal intubation using Airtraq 
optical laryngoscope in a patient of fracture zygomatic arch with cervical 
spine injury. The patient had predicted difficult direct laryngoscopy with 
restricted mouth opening.
EMTREE DRUG INDEX TERMS
  midazolam (intravenous drug administration); ondansetron (intravenous drug administration); suxamethonium (intravenous drug administration); thiopental (intravenous drug administration); tramadol (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Airtraq Optical laryngoscope; nasotracheal intubation; rigid laryngoscope; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; cervical spine injury; human; informed consent; male; middle aged; plastic surgery; tracheotomy; zygoma arch fracture; 
CAS REGISTRY NUMBERS
  midazolam (59467-70-8)
  ondansetron (103639-04-9, 116002-70-1, 99614-01-4)
  suxamethonium (306-40-1, 71-27-2)
  thiopental (71-73-8, 76-75-5)
  tramadol (27203-92-5, 36282-47-0)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2015122940
PUI
  L604837504
DOI
  10.5530/ami.2014.1.11
FULL TEXT LINK
  http://dx.doi.org/10.5530/ami.2014.1.11
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23490896&id=doi:10.5530%2Fami.2014.1.11&atitle=Use+of+airtraq+optical+laryngoscope+for+naso-tracheal+intubation+in+anaesthetized+patients&stitle=Acta+Med.+Int.&title=Acta+Medica+International&volume=1&issue=1&spage=41&epage=42&aulast=Malik&aufirst=Sunny&auinit=S.&aufull=Malik+S.&coden=&isbn=&pages=41-42&date=2014&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 457
TITLE
  Ganglioglioma in brainstem: Case report and a review of literatures
AUTHOR NAMES
  Kim S.-D.; Kim J.H.; Lee C.-Y.; Kim H.-W.
AUTHOR ADDRESSES
  (Kim S.-D.; Kim J.H., yellowsd1@naver.com; Lee C.-Y.; Kim H.-W.) Department 
of Neurosurgery, Konyang University Hospital, Daejeon, South Korea.
(Lee C.-Y.) Graduate School of Medicine, Kyung Hee University, Seoul, South 
Korea.
CORRESPONDENCE ADDRESS
  J. H. Kim, Department of Neurosurgery, Konyang University Hospital, 158 
Gwanjeodong-ro, Seo-gu, Daejeon 302-718, South Korea. Email: 
yellowsd1@naver.com
AiP/IP ENTRY DATE
  2014-05-20
FULL RECORD ENTRY DATE
  2014-05-23
SOURCE
  Journal of Korean Neurosurgical Society (2014) 55:3 (164-166). Date of 
Publication: 2014
VOLUME
  55
ISSUE
  3
FIRST PAGE
  164
LAST PAGE
  166
DATE OF PUBLICATION
  2014
ISSN
  1598-7876 (electronic)
  2005-3711
BOOK PUBLISHER
  Korean Neurosurgical Society, JKNS@paran.com
ABSTRACT
  Ganglioglioma is an infrequent tumor of the central nervous system (CNS); 
mostly supratentorial region. But, they can occur anywhere in the central 
nervous system such as brainstem, cerebellopontine angle (CPA), thalamus, 
optic nerve and spinal cord. Although it occurs rarely, ganglioglioma should 
be included in the differential diagnosis of a posterior fossa mass because 
early recognition is important for treatment and patient counseling. © 2014 
The Korean Neurosurgical Society.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); chromagranin (endogenous compound); glial fibrillary acid protein (endogenous compound); peptides and proteins (endogenous compound); protein S 100 (endogenous compound); synaptophysin (endogenous compound); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain stem tumor (diagnosis, surgery); glioma (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  article; aspiration pneumonia (drug therapy); ataxia; case report; cervical spinal cord; child; computer assisted tomography; consciousness; cranial nerve paralysis; craniotomy; drainage catheter; female; follow up; hemiparesis; histopathology; human; human tissue; immunohistochemistry; laminectomy; neurologic disease (etiology); neurologic examination; nose feeding; nuclear magnetic resonance imaging; nystagmus; obstructive hydrocephalus; pons angle; school child; seizure; sleep disordered breathing; tracheostomy; 
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014323315
PUI
  L373049076
DOI
  10.3340/jkns.2014.55.3.164
FULL TEXT LINK
  http://dx.doi.org/10.3340/jkns.2014.55.3.164
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15987876&id=doi:10.3340%2Fjkns.2014.55.3.164&atitle=Ganglioglioma+in+brainstem%3A+Case+report+and+a+review+of+literatures&stitle=J.+Korean+Neurosurg.+Soc.&title=Journal+of+Korean+Neurosurgical+Society&volume=55&issue=3&spage=164&epage=166&aulast=Kim&aufirst=Sung-Duk&auinit=S.-D.&aufull=Kim+S.-D.&coden=&isbn=&pages=164-166&date=2014&auinit1=S&auinitm=-D
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 458
TITLE
  Montgomery(©) T-tubes in the management of multilevel airway obstruction in 
mucopolysaccharidosis
AUTHOR NAMES
  Soni-Jaiswal A.; Penney S.E.; Jones S.A.; Walker R.; Rothera M.P.; Bruce I.A.
AUTHOR ADDRESSES
  (Soni-Jaiswal A., archanasj@gmail.com; Rothera M.P.; Bruce I.A.) Department 
of Paediatric Otolaryngology, Royal Manchester Children's Hospital, 
Manchester, United Kingdom.
(Penney S.E.) Department of Otolaryngology, Manchester Royal Infirmary, 
Manchester, United Kingdom.
(Jones S.A.) Willink Unit, Manchester Centre for Genomic Medicine, Central 
Manchester University Hospitals NHS Foundation Trust, University of 
Manchester, United Kingdom.
(Walker R.) Department of Paediatric Anaesthesia, Royal Manchester 
Children's Hospital, Manchester, United Kingdom.
(Bruce I.A.) Respiratory and Allergy Centre, Institute of Inflammation and 
Repair, University of Manchester, , United Kingdom.
CORRESPONDENCE ADDRESS
  A. Soni-Jaiswal, Department of Paediatric Otolaryngology, Royal Manchester 
Children's Hospital, Manchester, United Kingdom.
AiP/IP ENTRY DATE
  2014-08-06
FULL RECORD ENTRY DATE
  2014-11-04
SOURCE
  International Journal of Pediatric Otorhinolaryngology (2014) 78:10 
(1763-1768). Date of Publication: 1 Oct 2014
VOLUME
  78
ISSUE
  10
FIRST PAGE
  1763
LAST PAGE
  1768
DATE OF PUBLICATION
  1 Oct 2014
ISSN
  1872-8464 (electronic)
  0165-5876
BOOK PUBLISHER
  Elsevier Ireland Ltd
EMTREE DRUG INDEX TERMS
  glycosaminoglycan; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (therapy); endotracheal tube (adverse device effect); mucopolysaccharidosis; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; artificial ventilation; bone marrow transplantation; case report; child; computer assisted tomography; disease course; dyspnea; granulation tissue (complication); hospital readmission; human; Hunter syndrome; Hurler syndrome; limb weakness; macroglossia; male; Maroteaux Lamy syndrome (therapy); mitral valve replacement; nuclear magnetic resonance imaging; otorhinolaryngology microdebrider; oxygen consumption; preschool child; respiratory arrest; respiratory function; retrospective study; spinal cord compression (surgery); spinal cord decompression; tracheomalacia; tracheostomy; tracheostomy tube; tube removal; walking difficulty; 
DEVICE TRADE NAMES
  Bivona  Smiths Medical

  Flextend  Smiths Medical

  Medtronic Skimmer
  Microcuff  Kimberly Clark

  Montgomery
  Shiley  Covidien

EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Endocrinology (3)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2014712777
PUI
  L53269608
DOI
  10.1016/j.ijporl.2014.06.015
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijporl.2014.06.015
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18728464&id=doi:10.1016%2Fj.ijporl.2014.06.015&atitle=Montgomery%C2%A9+T-tubes+in+the+management+of+multilevel+airway+obstruction+in+mucopolysaccharidosis&stitle=Int.+J.+Pediatr.+Otorhinolaryngol.&title=International+Journal+of+Pediatric+Otorhinolaryngology&volume=78&issue=10&spage=1763&epage=1768&aulast=Soni-Jaiswal&aufirst=A.&auinit=A.&aufull=Soni-Jaiswal+A.&coden=IPOTD&isbn=&pages=1763-1768&date=2014&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 459
TITLE
  Vertebral artery injury in a patient with fractured C4 vertebra
AUTHOR NAMES
  Banić T.; Banić M.; Cvjetko I.; Somun N.; Bilić V.; Vidjak V.; Pavić V.; Coć I.; Kokić T.; Kejla Z.
AUTHOR ADDRESSES
  (Banić T., tihomir.banic@gmail.com; Somun N.; Bilić V.; Pavić V.; Coć I.; 
Kejla Z.) Department of Spine Surgery, University Hospital for Traumatology, 
Zagreb, Croatia.
(Banić M.) Department of Anesthesiology and Intensive Medicine, Sestre 
milosrdnice University Hospital Center, Zagreb, Croatia.
(Cvjetko I.) Department of Vascular Surgery, Merkur University Hospital, 
Zagreb, Croatia.
(Vidjak V.) Department of Interventional Radiology, Merkur University 
Hospital, Zagreb, Croatia.
(Kokić T.) Division of Traumatology and Bone and Joint Surgery, Zagreb 
University Hospital Center, Department of Surgery, Zagreb, Croatia.
CORRESPONDENCE ADDRESS
  T. Banić, Department of Spine Surgery, University Hospital for Traumatology, 
Sestre milosrdnice University Hospital Center, Draškoviceva 19, Zagreb, 
Croatia.
AiP/IP ENTRY DATE
  2015-02-04
FULL RECORD ENTRY DATE
  2015-02-10
SOURCE
  Acta Clinica Croatica (2014) 53:3 (369-373). Date of Publication: 2014
VOLUME
  53
ISSUE
  3
FIRST PAGE
  369
LAST PAGE
  373
DATE OF PUBLICATION
  2014
ISSN
  1333-9451 (electronic)
  0353-9466
BOOK PUBLISHER
  Klinicka Bolnica Sestre Milosrdnice
ABSTRACT
  Vertebral artery injuries due to cervical spine trauma, although rarely 
described in the literature, are relatively common. While most of them will 
remain asymptomatic, a small percentage of patients may suffer life 
threatening complications. We report a case of the right vertebral artery 
injury in a patient with fracture of C4 vertebra, successfully treated with 
endovascular approach. A 78-year-old male patient was hospitalized for 
cervical spine injury caused by falling off the tractor. Radiological 
assessment revealed fracture of C4 vertebra with proximal two-thirds of C4 
body dislocated five millimeters dorsally. Significant swelling of soft 
prevertebral tissues distally of C2 segment was also present. During 
emergency surgery using standard anterior approach for cervical spine, 
excessive bleeding started from the injured right vertebral artery. Bleeding 
was stopped by tamponade with oxidized regenerated cellulose sheet and C4-C5 
anterior fixation; then partial reduction of displacement was done. Fifteen 
days later, after angiography, endovascular repair of the right vertebral 
artery was performed using percutaneous stent graft. Follow up computed 
tomography scan angiography showed valid stent patency without contrast 
extravasation. In cases of cervical spine trauma, surgeon should always be 
prepared to manage injury of vertebral artery. Bleeding can primarily be 
stopped by hemostatic packing, and definitive repair can be successfully 
achieved by endovascular approach using percutaneous stent graft.
EMTREE DRUG INDEX TERMS
  acetylsalicylic acid (drug combination); analgesic agent (drug combination); clopidogrel (drug combination); fresh frozen plasma; low molecular weight heparin; methylprednisolone (drug combination, drug therapy); oxidized regenerated cellulose; proton pump inhibitor (drug combination); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artery injury (diagnosis, therapy); cervical spine dislocation (diagnosis, rehabilitation, surgery); fourth cervical vertebra; vertebral artery; vertebral artery injury (diagnosis, therapy); 
EMTREE MEDICAL INDEX TERMS
  aged; anticoagulant therapy; artery rupture; article; artificial ventilation; bone graft; case report; cervical spine injury; cervical spine radiography; colloid; computed tomographic angiography; continuous infusion; contrast medium extravasation; corticosteroid therapy; crystalloid; discectomy; edema (drug therapy); emergency surgery; endotamponade; endovascular surgery; erythrocyte concentrate; falling; follow up; fracture reduction; graft patency; hematoma (complication); hemostasis; human; intensive care unit; male; operative blood loss; osteochondrosis (diagnosis); preoperative evaluation; spine stabilization; spondylosis (diagnosis); surgical approach; tracheostomy; vascular stent; vertebra body; 
DEVICE TRADE NAMES
  Surgicel
CAS REGISTRY NUMBERS
  acetylsalicylic acid (493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1)
  clopidogrel (113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8)
  methylprednisolone (6923-42-8, 83-43-2)
  oxidized regenerated cellulose (82347-53-3)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, unknown
EMBASE ACCESSION NUMBER
  2015705059
MEDLINE PMID
  25509251 (http://www.ncbi.nlm.nih.gov/pubmed/25509251)
PUI
  L601923905
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13339451&id=doi:&atitle=Vertebral+artery+injury+in+a+patient+with+fractured+C4+vertebra&stitle=Acta+Clin.+Croat.&title=Acta+Clinica+Croatica&volume=53&issue=3&spage=369&epage=373&aulast=Bani%C4%87&aufirst=Tihomir&auinit=T.&aufull=Bani%C4%87+T.&coden=ACLCE&isbn=&pages=369-373&date=2014&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 460
TITLE
  Phrenic nerve stimulation for diaphragm pacing in a quadriplegic patient
AUTHOR NAMES
  Son B.-C.; Kim D.-R.; Kim I.-S.; Hong J.T.
AUTHOR ADDRESSES
  (Son B.-C., sbc@catholic.ac.kr) Department of Neurosurgery, Seoul St. Mary's 
Hospital, The Catholic Univeristy of Korea College of Medicine, Seoul, South 
Korea.
(Kim D.-R.; Kim I.-S.; Hong J.T.) Department of Neurosurgery, St. Vincent's 
Hospital, The Catholic Univeristy of Korea College of Medicine, Suwon, South 
Korea.
(Son B.-C., sbc@catholic.ac.kr) The Catholic Neuroscience, College of 
Medicine, The Catholic Univeristy of Korea, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  B.-C. Son, Department of Neurosurgery, Seoul St. Mary's Hospital, The 
Catholic Neuroscience Institute, College of Medicine, The Catholic 
University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 
137-701, South Korea. Email: sbc@catholic.ac.kr
AiP/IP ENTRY DATE
  2013-11-27
FULL RECORD ENTRY DATE
  2013-12-21
SOURCE
  Journal of Korean Neurosurgical Society (2013) 54:4 (359-362). Date of 
Publication: 2013
VOLUME
  54
ISSUE
  4
FIRST PAGE
  359
LAST PAGE
  362
DATE OF PUBLICATION
  2013
ISSN
  2005-3711
  1598-7876 (electronic)
BOOK PUBLISHER
  Korean Neurosurgical Society, #407, Dong-A Villate 2nd Town, 1678-2 
Seocho-dong, Seocho-gu, Seoul, South Korea.
ABSTRACT
  Chronic hypoventilation due to injury to the brain stem respiratory center 
or high cervical cord (above the C3 level) can result in dependence to 
prolonged mechanical ventilation with tracheostomy, frequent nosocomial 
pneumonia, and prolonged hospitalization. Diaphragm pacing through 
electrical stimulation of the phrenic nerve is an established treatment for 
central hypoventilation syndrome. We performed chronic phrenic nerve 
stimulation for diaphragm pacing with the spinal cord stimulator for pain 
control in a quadriplegic patient with central apnea due to complete spinal 
cord injury at the level of C2 from cervical epidural hematoma. After 
diaphragmatic pacing, the patient who was completely dependent on the 
mechanical ventilator could ambulate up to three hours every day without aid 
of mechanical ventilation during the 12 months of follow-up. Diaphragm 
pacing through unilateral phrenic nerve stimulation with spinal cord 
stimulator was feasible in an apneic patient with complete quadriplegia who 
was completely dependent on mechanical ventilation. Diaphragm pacing with 
the spinal cord stimulator is feasible and effective for the treatment of 
the central hypoventilation syndrome. © 2013 The Korean Neurosurgical 
Society.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); warfarin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm movement; nerve stimulation; phrenic nerve; phrenic nerve pacing; quadriplegia; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; case report; clinical examination; dyspnea; electrode; electromyography; end tidal carbon dioxide tension; epidural hematoma (diagnosis); female; fluoroscopy; human; implantable pulse generator; implanted phrenic nerve stimulator; mobilization; nuclear magnetic resonance imaging; oxygen saturation; paraplegia; pneumonia (complication, drug therapy, prevention); respiratory distress (therapy); tachypnea; tendon reflex; thromboembolism (drug therapy); 
DEVICE TRADE NAMES
  Eclipse Neurologial Workstation  , United StatesAxon

  Eon-Mini Rechargeable  , United StatesSt Jude

  Quatrode  , United StatesSt Jude

DEVICE MANUFACTURERS
   (United States)Axon
   (United States)St Jude
CAS REGISTRY NUMBERS
  warfarin (129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013730895
PUI
  L370305545
DOI
  10.3340/jkns.2013.54.4.359
FULL TEXT LINK
  http://dx.doi.org/10.3340/jkns.2013.54.4.359
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20053711&id=doi:10.3340%2Fjkns.2013.54.4.359&atitle=Phrenic+nerve+stimulation+for+diaphragm+pacing+in+a+quadriplegic+patient&stitle=J.+Korean+Neurosurg.+Soc.&title=Journal+of+Korean+Neurosurgical+Society&volume=54&issue=4&spage=359&epage=362&aulast=Son&aufirst=Byung-Chul&auinit=B.-C.&aufull=Son+B.-C.&coden=&isbn=&pages=359-362&date=2013&auinit1=B&auinitm=-C
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 461
TITLE
  Complications due to the use of BMP/INFUSE in spine surgery: The evidence 
continues to mount
AUTHOR NAMES
  Epstein N.
AUTHOR ADDRESSES
  (Epstein N., nancy.epsteinmd@gmail.com) Department of Neurosurgery, Winthrop 
University Hospital, Mineola, NY 11501, United States.
(Epstein N., nancy.epsteinmd@gmail.com) Long Island Neurosurgical Assoc. 
P.C., 410 Lakeville Rd, New Hyde Park, NY 11042, United States.
CORRESPONDENCE ADDRESS
  N. Epstein, Department of Neurosurgery, Winthrop University Hospital, 
Mineola, NY 11501, United States. Email: nancy.epsteinmd@gmail.com
AiP/IP ENTRY DATE
  2013-12-03
FULL RECORD ENTRY DATE
  2013-12-05
SOURCE
  Surgical Neurology International (2013) 4:SUPPL5 (S343-S351). Date of 
Publication: 2013
VOLUME
  4
ISSUE
  SUPPL5
DATE OF PUBLICATION
  2013
ISSN
  2152-7806 (electronic)
BOOK PUBLISHER
  Medknow Publications and Media Pvt. Ltd, B9, Kanara Business Centre, off 
Link Road, Ghatkopar (E), Mumbai, India.
ABSTRACT
  Increasingly, adverse events (AE) attributed to utilizing BMP/INFUSE (Bone 
Morphogenetic Protein, Medtronic, Memphis, TN, USA) "off-label" in spine 
surgery are being reported. In 2008, the Food and Drug Administration (FDA) 
issued a warning that in anterior cervical spine surgery, the "off-label" 
use of BMP/INFUSE contributed to marked dysphagia, hematoma, seroma, 
swelling, and/or the need for intubation/tracheostomy. Subsequent studies 
have cited the following AE; heterotopic ossification (HO), osteolysis, 
infection, arachnoiditis, increased neurological deficits, retrograde 
ejaculation, and cancer. Furthermore, in 2011, Carragee et al. noted that 13 
of the original industry-sponsored BMP/INFUSE spinal surgery studies failed 
to acknowledge multiple AE. Additionally, in 2012, Comer et al. observed 
that the frequency of retrograde ejaculation reported for BMP/INFUSE used 
"on-label" to perform Anterior Lumbar Interbody Fusion/Lumbar Tapered 
Fusion-Cage Device (ALIF/LT-Cage) was also largely "under-reported." To 
summarize, there is mounting evidence in the spinal literature that 
utilizing BMP/INFUSE in spinal fusions contributes to major perioperative 
and postoperative morbidity.Copyright: © 2013 Li CH.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  recombinant bone morphogenetic protein 2 (adverse drug reaction, clinical 
trial, drug therapy, intramuscular drug administration, pharmacoeconomics, 
subcutaneous drug administration); 
EMTREE DRUG INDEX TERMS
  amplify; collagen sponge; corticosteroid (drug therapy); infuse; methylprednisolone (clinical trial, drug therapy, intraperitoneal drug 
administration); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug safety; evidence based medicine; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  arachnoiditis (side effect); article; body weight loss; bone malformation (side effect); bone pain (side effect); bone transplantation; cancer risk; cost benefit analysis; drug contraindication; drug cost; drug efficacy; drug megadose; drug surveillance program; dysphagia (side effect); Food and Drug Administration; health care cost; hematoma (side effect); heterotopic ossification (side effect); heterotopic retroperitoneal ossification (side effect); heterotopic retroperitoneal ossification (side effect); human; iliac crest; infection (side effect); intervertebral disk degeneration (disease management, drug therapy, surgery); intubation; lumbar tapered fusion device system; morbidity; neoplasm (side effect); neurologic disease (side effect); neurosurgery; nonhuman; off label drug use; osteolysis; pain (side effect); perioperative period; postoperative period; priority journal; pseudarthrosis (side effect); public health; quality adjusted life year; radiculitis (side effect); radiculopathy (side effect); randomized controlled trial (topic); respiratory distress (side effect); retrograde ejaculation (side effect); risk benefit analysis; seroma (side effect); side effect (side effect); soft tissue inflammation (drug therapy, side effect); spine fusion; spine fusion implant; spondylolisthesis (disease management, drug therapy, surgery); surgical infection (side effect); swelling (side effect); thromboembolism (side effect); tissue engineering; tracheostomy; urine retention (side effect); visual analog scale; 
DRUG TRADE NAMES
  amplify  , United StatesMedtronic

  infuse  , United StatesMedtronic

DRUG MANUFACTURERS
   (United States)Medtronic
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
  recombinant bone morphogenetic protein 2 (246539-15-1)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013696127
PUI
  L370181090
DOI
  10.4103/2152-7806.114813
FULL TEXT LINK
  http://dx.doi.org/10.4103/2152-7806.114813
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21527806&id=doi:10.4103%2F2152-7806.114813&atitle=Complications+due+to+the+use+of+BMP%2FINFUSE+in+spine+surgery%3A+The+evidence+continues+to+mount&stitle=Surg.+Neurol.+Intl.&title=Surgical+Neurology+International&volume=4&issue=SUPPL5&spage=&epage=&aulast=Epstein&aufirst=Nancy&auinit=N.&aufull=Epstein+N.&coden=&isbn=&pages=-&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 462
TITLE
  Value of preventive tracheotomy in patients with acute cervical spinal cord 
injury
AUTHOR NAMES
  Wu H.-T.; Zhao C.-P.; Li Z.; Yan J.-C.; Hao J.-D.; Li Z.-Y.
AUTHOR ADDRESSES
  (Wu H.-T., surgeon_wu@126.com; Zhao C.-P.; Li Z.; Yan J.-C.; Hao J.-D.; Li 
Z.-Y.) Department of Orthopedic Surgery, Third Hospital, Hebei Medical 
University, Shijiazhuang 050051, China.
CORRESPONDENCE ADDRESS
  H.-T. Wu, Department of Orthopedic Surgery, Third Hospital, Hebei Medical 
University, Shijiazhuang 050051, China. Email: surgeon_wu@126.com
AiP/IP ENTRY DATE
  2014-01-06
FULL RECORD ENTRY DATE
  2014-01-15
SOURCE
  National Medical Journal of China (2013) 93:47 (3762-3765). Date of 
Publication: 2013
VOLUME
  93
ISSUE
  47
FIRST PAGE
  3762
LAST PAGE
  3765
DATE OF PUBLICATION
  2013
ISSN
  0376-2491
BOOK PUBLISHER
  Chinese Medical Association, 42 Dongsi Xidajie, Beijing, China.
ABSTRACT
  Objective: To evaluate the value of preventive tracheotomy in patients with 
acute cervical spinal cord injury. Methods: A retrospective analysis was 
performed on 54 cases of severe C4-C8 cervical spinal cord injury patients 
undergoing anterior fixation. They were classified as A and B according to 
the criteria of American Spinal Injury Association. And no tracheotomy was 
performed preoperatively. The patients with a high risk of dyspnea and with 
an indication for preventive tracheotomy received a preventive tracheotomy 
right after anterior fixation. 11 cases were classified into tracheotomy 
group and 43 cases were in non-tracheotomy group. The preoperative and 
hospital stays, incidence of hyoxemia and pulmonary infection, incidence of 
surgical incision site infection and mortality were analyzed between two 
groups. Results: The preoperative and hospital stays of tracheotomy group 
were shorter than those of non-tracheotomy group (2.9±1.2 vs 5.7±4.4 days, 
10.3±4.0 vs 16.5±9.2 days). The incidence of hyoxemia was lower in 
tracheotomy group (9.1% vs 44.2%). There was difference existed between two 
groups. 44.2% patients in the non-tracheotomy group underwent tracheotomy or 
endotracheal intubation for dyspnea and hyoxemia. There was no significant 
difference between two groups in the incidence of pulmonary infection (9.1% 
vs 7.0%) or surgical incision site infection (0 vs 2.3%). The mortality of 
non-tracheotomy group was 3.07 folds of that of tracheotomy group (9.1% vs 
27.9%). But there was no significant statistical difference. Conclusion: The 
preventive tracheotomy is an effective solution for the patients with 
respiratory compromises, a high risk of dyspnea and with an indication for 
preventive tracheotomy. The preventive tracheotomy for severe cervical 
spinal cord can improve respiratory function effectively and fixation may be 
performed earlier. And there are lower rates of mortality and infection. 
Copyright © 2013 by the Chinese Medical Association.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); preventive tracheotomy; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  anterior spine fusion; article; cervical spine; controlled study; dyspnea (surgery, therapy); endotracheal intubation; high risk patient; hospitalization; human; hypoxemia (surgery, therapy); lung infection; major clinical study; preoperative period; retrospective study; surgical infection; surgical mortality; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  Chinese, English
EMBASE ACCESSION NUMBER
  2014001138
MEDLINE PMID
  24548393 (http://www.ncbi.nlm.nih.gov/pubmed/24548393)
PUI
  L372008111
DOI
  10.3760/cma.j.issn.0376-2491.2013.47.011
FULL TEXT LINK
  http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2013.47.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03762491&id=doi:10.3760%2Fcma.j.issn.0376-2491.2013.47.011&atitle=Value+of+preventive+tracheotomy+in+patients+with+acute+cervical+spinal+cord+injury&stitle=Nat.+Med.+J.+China&title=National+Medical+Journal+of+China&volume=93&issue=47&spage=3762&epage=3765&aulast=Wu&aufirst=Hao-Tian&auinit=H.-T.&aufull=Wu+H.-T.&coden=&isbn=&pages=3762-3765&date=2013&auinit1=H&auinitm=-T
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 463
TITLE
  History of hereditary motor and sensory neuropathy with proximal dominant 
involvement (HMSN-P)
AUTHOR NAMES
  Takashima H.
AUTHOR ADDRESSES
  (Takashima H.) Department of Neurology and Geriatrics, Kagoshima University 
Graduate School of Medical and Dental Sciences, Japan.
CORRESPONDENCE ADDRESS
  H. Takashima, Department of Neurology and Geriatrics, Kagoshima University 
Graduate School of Medical and Dental Sciences, Japan.
AiP/IP ENTRY DATE
  2014-01-15
FULL RECORD ENTRY DATE
  2014-01-17
SOURCE
  Clinical Neurology (2013) 53:11 (1196-1198). Date of Publication: 2013
VOLUME
  53
ISSUE
  11
FIRST PAGE
  1196
LAST PAGE
  1198
DATE OF PUBLICATION
  2013
ISSN
  0009-918X
BOOK PUBLISHER
  Societas Neurologica Japonica, 31-21 Yushima 2-chome, Bunkyo-ku, Tokyo, 
Japan.
ABSTRACT
  We established a new disease autosomal dominant hereditary motor and sensory 
neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, 
Japan. This disease is characterized by proximal dominant neurogenic atrophy 
with fasciculations, painful muscle cramp, obvious sensory nerve 
involvement, areflexia, high incidence of elevated creatine kinase levels, 
hyperlipidemia and hyperglycemia. (MIM %604484). HMSNP is so called or HMSNO 
(HMSN OKINAWA type),. These clinical features resembled those of 
Kennedy-Alter-Sung syndrome. Most HMSNP patients have severe muscle atrophy 
and finally the tracheostomy and artificial ventilation are required. 
Therefore, we initially thought to classify HMSNP into a subtype of motor 
neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or 
spinal muscular atrophy (SMA). However, the general consensus for MND was no 
sensory involvement. Therefore, as the disease showed severe sensory 
involvement, we categorized HMSNP in subtype of HMSN at that time. We also 
reported the pathology of HMSNP, showing severely decreased anterior horn 
cells, decreased posterior horn cells, and loss of posterior funiculus in 
the spinal cord.
EMTREE DRUG INDEX TERMS
  creatine kinase (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hereditary motor sensory neuropathy; 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; anterior horn cell; areflexia; article; artificial ventilation; autosomal dominant inheritance; clinical feature; fasciculation; human; hyperglycemia; hyperlipidemia; incidence; Japan; motor neuron disease; muscle atrophy; muscle cramp; posterior horn cell; sensory nerve; spinal cord; spinal muscular atrophy; tracheostomy; 
CAS REGISTRY NUMBERS
  creatine kinase (9001-15-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Human Genetics (22)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2014017689
PUI
  L372065264
DOI
  10.5692/clinicalneurol.53.1196
FULL TEXT LINK
  http://dx.doi.org/10.5692/clinicalneurol.53.1196
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0009918X&id=doi:10.5692%2Fclinicalneurol.53.1196&atitle=History+of+hereditary+motor+and+sensory+neuropathy+with+proximal+dominant+involvement+%28HMSN-P%29&stitle=Clin.+Neurol.&title=Clinical+Neurology&volume=53&issue=11&spage=1196&epage=1198&aulast=Takashima&aufirst=Hiroshi&auinit=H.&aufull=Takashima+H.&coden=RISHD&isbn=&pages=1196-1198&date=2013&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 464
TITLE
  Critical care management of patients with acute spinal cord injury
AUTHOR NAMES
  Lo V.; Esquenazi Y.; Han M.-K.; Lee K.
AUTHOR ADDRESSES
  (Lo V.; Esquenazi Y.; Lee K., Kiwon.Lee@uth.tmc.edu) Department of 
Neurosurgery, University of Texas Health Science Center at Houston, Medical 
School, 6431 FanninSt., Houston, TX 77030, United States.
(Han M.-K.) Department of Neurology, Seoul National University, Boondang 
Hospital, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  K. Lee, Department of Neurosurgery, University of Texas Health Science 
Center at Houston, Medical School, 6431 FanninSt., Houston, TX 77030, United 
States. Email: Kiwon.Lee@uth.tmc.edu
AiP/IP ENTRY DATE
  2013-12-09
FULL RECORD ENTRY DATE
  2013-12-12
SOURCE
  Journal of Neurosurgical Sciences (2013) 57:4 (281-292). Date of 
Publication: December 2013
VOLUME
  57
ISSUE
  4
FIRST PAGE
  281
LAST PAGE
  292
DATE OF PUBLICATION
  December 2013
ISSN
  0390-5616
  1827-1855 (electronic)
BOOK PUBLISHER
  Edizioni Minerva Medica, Corso Bramante 83-85, Torino, Italy.
ABSTRACT
  Spinal cord injury (SCI) inevitably extends beyond neurologic consequences. 
The relationship between the spinal cord and its control of other organ 
systems make SCI management complex, requiring treatment on a multisystem 
approach. Patients frequently have hemodynamic instability and respiratory 
insufficiency secondary to the neurologic insult. Rigorous monitoring and 
anticipation of potential complications are essential in managing SCI, 
requiring a level of care provided in a neurocritical care unit. This review 
covers the pathophysiology, initial assessment, and stabilization in 
addition to acute management of cardiovascular and respiratory issues 
following SCI. Subsequent potential complications of deep vein thrombosis, 
gastrointestinal, and urinary systems and their management in the critical 
care setting are also addressed in this review.
EMTREE DRUG INDEX TERMS
  dobutamine (drug therapy); dopamine (drug therapy); epinephrine (drug therapy); heparin (drug therapy, oral drug administration); low molecular weight heparin (drug therapy, oral drug administration); methylprednisolone (drug therapy); noradrenalin (drug therapy); phenylephrine (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; patient care; spinal cord injury (drug therapy, drug therapy, epidemiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  anticoagulant therapy; cervical spinal cord injury; cervical spine fracture (surgery); clinical assessment; computer assisted tomography; deep vein thrombosis (complication); diaphragm paralysis; forced vital capacity; fracture reduction; Glasgow coma scale; human; hypotension; immobilization; intubation; kidney failure (complication); life expectancy; lung embolism (complication, drug therapy, prevention); nonhuman; nuclear magnetic resonance imaging; nutritional support; paralytic ileus (complication, therapy); pathophysiology; range of motion; review; sensorimotor function; spinal cord decompression; spine radiography; steroid therapy; tracheobronchial toilet; tracheostomy; urinary tract infection (complication); 
CAS REGISTRY NUMBERS
  adrenalin (51-43-4, 55-31-2, 6912-68-1)
  dobutamine (34368-04-2, 49745-95-1, 52663-81-7, 61661-06-1)
  dopamine (51-61-6, 62-31-7)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
  methylprednisolone (6923-42-8, 83-43-2)
  noradrenalin (1407-84-7, 51-41-2)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013759454
MEDLINE PMID
  24091430 (http://www.ncbi.nlm.nih.gov/pubmed/24091430)
PUI
  L370377165
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03905616&id=doi:&atitle=Critical+care+management+of+patients+with+acute+spinal+cord+injury&stitle=J.+Neurosurg.+Sci.&title=Journal+of+Neurosurgical+Sciences&volume=57&issue=4&spage=281&epage=292&aulast=Lo&aufirst=V.&auinit=V.&aufull=Lo+V.&coden=JNSSB&isbn=&pages=281-292&date=2013&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 465
TITLE
  Rare site hemorrhages in patients with hemophilia
AUTHOR NAMES
  Toshniwal M.; Chandrakala S.; Mahesh R.; Jijina F.; Ghosh K.
AUTHOR ADDRESSES
  (Toshniwal M.)
(Chandrakala S.; Mahesh R.) Department of Hematology, KEM Hospital, Mumbai, 
India.
(Jijina F.) Hinduja Hospital, Mumbai, India.
(Ghosh K.) National Institute of Immunohaematology (ICMR), KEM Hospital, 
Mumbai, India.
CORRESPONDENCE ADDRESS
  M. Toshniwal,
FULL RECORD ENTRY DATE
  2013-11-15
SOURCE
  Indian Journal of Hematology and Blood Transfusion (2013) 29:4 (343-344). 
Date of Publication: December 2013
VOLUME
  29
ISSUE
  4
FIRST PAGE
  343
LAST PAGE
  344
DATE OF PUBLICATION
  December 2013
CONFERENCE NAME
  54th Annual Conference of Indian Society of Haematology and Blood 
Transfusion, Haematacon 2013
CONFERENCE LOCATION
  Mumbai, India
CONFERENCE DATE
  2013-11-07 to 2013-11-10
ISSN
  0971-4502
BOOK PUBLISHER
  Springer India
ABSTRACT
  Introduction: Patients with congenital or acquired clotting disorders are at 
increased risk for experiencing spontaneous hemorrhage into unusual sites. 
Besides hemarthrosis that are frequently observed in Hemophiliacs, bleeding 
may also rarely occur in various soft tissues or solid organs. Subdural 
hematomas and other central nervous system (CNS) hemorrhages are uncommon 
but represent a major cause of death and disability. Spontaneous spinal 
subdural hematoma is a rare subtype of CNS hemorrhage in patients with 
hemophilia, reported in only a handful of cases in the literature. Epidural 
hematomas have been reported somewhat more frequently, but are still rare. 
Diffuse alveolar hemorrhage is hardly been reported in cases of hemophilia. 
We report nine cases of hemophilia from our comprehensive hemophilic care 
center of western India presenting with bleeding at very rare and unusual 
sites. Four cases presented with severe anemia, jaundice, dyspnea and 
hemoptysis with HRCT chest suggestive of diffuse alveolar hemorrhage. All 
were managed conservatively with adequate factor replacement and supportive 
treatment. Two young adult patients had history of jerk while riding bike in 
village and after 3-4 days presented with paraparesis of subacute onset with 
bowel and bladder involvement with MRI spine showing spinal subdural 
hematoma, managed with factor replacement. Another 5 year old boy presented 
with acute onset weakness in both lower limbs after trivial trauma whose MRI 
spine revealed large epidural hematoma. This was treated with adequate and 
timely factor replacement leading to complete neurological and functional 
recovery. A young patient presented first time with swelling of neck, 
rapidly progressive dyspnoea and stridor after mild trauma to the neck by 
slipping from staircase. On examination had neck muscle hematoma and 
ultimately needed tracheotomy as life saving measure. A 22 year male 
presented with fever and pain in abdomen, USG was s/o splenic rupture with 
perislpenic hematoma with left sided pleural effusion. Patient factor assay 
was factor VIII levels<1 %. He was managed conservatively.
EMTREE DRUG INDEX TERMS
  blood clotting factor 8; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bleeding; blood transfusion; hematology; hemophilia; human; Indian; patient; society; 
EMTREE MEDICAL INDEX TERMS
  abdomen; adult; anemia; assay; bladder; blood clotting disorder; boy; cause of death; central nervous system; disability; dyspnea; epidural hematoma; examination; fever; hemarthrosis; hematoma; hemoptysis; India; injury; intestine; jaundice; leg; lung hemorrhage; male; muscle hematoma; neck; neck muscle; nuclear magnetic resonance imaging; pain; paraplegia; pleura effusion; risk; soft tissue; solid; spinal hematoma; spine; spleen rupture; stridor; subdural hematoma; swelling; thorax; tracheotomy; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71223236
DOI
  10.1007/s12288-013-0302-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12288-013-0302-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09714502&id=doi:10.1007%2Fs12288-013-0302-z&atitle=Rare+site+hemorrhages+in+patients+with+hemophilia&stitle=Indian+J.+Hematol.+Blood+Transfus.&title=Indian+Journal+of+Hematology+and+Blood+Transfusion&volume=29&issue=4&spage=343&epage=344&aulast=Toshniwal&aufirst=Manoj&auinit=M.&aufull=Toshniwal+M.&coden=&isbn=&pages=343-344&date=2013&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 466
TITLE
  An analysis of surgical feeding tube placement in trauma patients
AUTHOR NAMES
  Fox N.; Hall H.; Patel Y.; Capano-Wehrle L.; Torjman M.; Seamon M.
AUTHOR ADDRESSES
  (Fox N.; Hall H.; Patel Y.; Capano-Wehrle L.) Cooper University Hospital, 
Camden, United States.
(Torjman M.) Cooper University Hospital, Anesthesiology, Camden, United 
States.
(Seamon M.) Camden, United States.
CORRESPONDENCE ADDRESS
  N. Fox, Cooper University Hospital, Camden, United States.
FULL RECORD ENTRY DATE
  2014-07-22
SOURCE
  Critical Care Medicine (2013) 41:12 SUPPL. 1 (A50). Date of Publication: 
December 2013
VOLUME
  41
ISSUE
  12
FIRST PAGE
  A50
DATE OF PUBLICATION
  December 2013
CONFERENCE NAME
  43rd Critical Care Congress of the Society of Critical Care Medicine, SCCM 
2014
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2014-01-09 to 2014-01-13
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: While surgical feeding tube (SFT) placement is common in 
trauma patients, the indications for SFT placement are poorly defined. 
Patient selection is critical as complications attributable to SFTs are 
reported in up to 20% of patients. We hypothesized that a significant number 
of SFTs placed in trauma patients were unnecessary. Our primary study 
objective was to determine clinical predictors of prolonged SFT use to avoid 
the unnecessary placement of SFTs. Methods: A retrospective review of 
patients (≥ 18 yrs) at our Level 1 trauma center with an ICU LOS ≥ 4 days 
that had a SFT placed (2007-2010) was conducted. “Necessary” SFT use was 
defined per established guidelines as either daily tube feeding through 
discharge or ≥ 28 day and “unnecessary” SFT use as all others. Clinical 
variables and outcomes were analyzed with respect to SFT use and type (PEG 
v. open). Univariate and multivariate analyses determined predictors of 
necessary SFT placement. Results: Study patients (n=398) were 49 ± 21 years 
of age with an ISS of 20 ± 9, primarily blunt injuries (90%) and an ICU LOS 
of 19 ± 11 days. Of 398 SFTs, 300 (73%) were necessary and 98 (27%) 
unnecessary (duration of unnecessary SFT use, 14 ± 8 days). No differences 
in gender, ISS, GCS or the presence of thoracic injury were identified 
between patients with necessary or unnecessary SFTs (all p >0.05). When 
stratified by SFT type, necessary SFTs were more common in patients that had 
PEG (n=278) rather than open (n=120) SFTs (81% v. 62%;p=0.001). After 
controlling for potential confounding variables, multiple variable logistic 
regression analysis revealed that advancing age (OR 1.02 per year, 
1.00-1.03), traumatic brain (OR 2.47, 1.33-4.51) or spinal cord injury (OR 
13.10, 3.03-56.62) and tracheostomy placement (OR 5.29, 2.72-12.32) each 
independently predicted necessary SFT placement. Conclusions: Our results 
suggest that patients with advancing age, traumatic brain or spinal cord 
injuries and those that have a tracheostomy placed are more likely to have 
necessary SFTs placed. The placement of SFTs in patients without these 
clinical characteristics should be performed with caution as they are more 
likely to be unnecessary.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  feeding apparatus; human; injury; intensive care; patient; society; 
EMTREE MEDICAL INDEX TERMS
  blunt trauma; brain; confounding variable; emergency health service; enteric feeding; gender; logistic regression analysis; multivariate analysis; patient selection; spinal cord injury; thorax injury; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71533409
DOI
  10.1097/01.ccm.0000439369.12993.08
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000439369.12993.08
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000439369.12993.08&atitle=An+analysis+of+surgical+feeding+tube+placement+in+trauma+patients&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=41&issue=12&spage=A50&epage=&aulast=Fox&aufirst=Nicole&auinit=N.&aufull=Fox+N.&coden=&isbn=&pages=A50-&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 467
TITLE
  Acute on chronic respiratory failure in 79 year old male
AUTHOR NAMES
  Patel D.; Hamarshi M.
AUTHOR ADDRESSES
  (Patel D.; Hamarshi M.) University of Missouri-Kansas City, Kansas City, 
United States.
(Patel D.; Hamarshi M.) Saint Luke's Hospital of Kansas City, Kansas City, 
United States.
CORRESPONDENCE ADDRESS
  D. Patel, University of Missouri-Kansas City, Kansas City, United States.
FULL RECORD ENTRY DATE
  2014-07-22
SOURCE
  Critical Care Medicine (2013) 41:12 SUPPL. 1 (A303-A304). Date of 
Publication: December 2013
VOLUME
  41
ISSUE
  12
FIRST PAGE
  A303
LAST PAGE
  A304
DATE OF PUBLICATION
  December 2013
CONFERENCE NAME
  43rd Critical Care Congress of the Society of Critical Care Medicine, SCCM 
2014
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2014-01-09 to 2014-01-13
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: 79 year old male presented with generalized weakness, slurred 
speech, altered mental status and labored breathing for several hours along 
with 20 pound weight loss over 6 months. Patient had three admissions at 
different hospital over the last 3 months for similar but milder 
presentation. Past work up included CT scan of the chest which was 
unrevealing and pulmonary function test (PFT) which showed restrictive lung 
disease with FEV1 of 48%, FVC of 44% of predicted and FEV1/FVC 84, though he 
was given the diagnosis of chronic obstructive pulmonary disease (COPD) as 
an explanation of his hyperbaric respiratory failure. Physical exam in the 
ED was pertinent for tachycardia, labored shallow breathing and lethargy. 
Auscultation of his chest demonstrated bilateral decreased breath sound. An 
arterial blood gas analysis showed pH of 7.04, PaCO2 of >130.00 mmHg and 
PaO2 of 218 mmHg on 100% oxygen. Chest x-ray and CT scan of the head were 
both unremarkable for acute process. Hypercarbia was initially attributed to 
possible COPD and obstructive sleep apnea (OSA). Patient's trachea 
immediately intubated and mechanical ventilation was begun. After borderline 
spontaneous breathing trial, patient was extubated next morning. Patient 
required bi-level noninvasive positive pressure mechanical ventilation 
(NIPPV) for moderate respiratory distress after extubation. A repeat 
physical examination was remarkable for impaired dorsiflexion of right 
ankle, tongue fasciculation and weak negative inspiratory force. There was 
no evidence of upper motor neuron dysfunction. Work up for neuromuscular 
weakness included antiacetylcholine receptor antibody, which was negative 
and electromyography, which demonstrated 2+ fasciculation and fibrillation 
potentials in >3 muscle groups. A diagnosis of progressive muscular atrophy 
(PMA) with early respiratory failure was made; it is believed to be a rare 
form of Amyotrophic Lateral Sclerosis (ALS). After discussing the merits and 
demerits of invasive mechanical ventilation via tracheostomy and gastrostomy 
tube insertion, he opted for comfort care. ALS is a neurodegenerative 
disease characterized by progressive muscular paralysis due to degeneration 
of lower and upper motor neurons in the primary motor cortex, brainstem, and 
spinal cord. Muscular paralysis is progressive and typically leads to death 
due to respiratory failure within 2-5 years of onset. However, only 3.0% of 
patients with ALS present with respiratory symptoms and 14% of this 
subpopulation requires mechanical respiratory support, a rare presentation 
of ALS. Clinical features of early respiratory failure like dyspnea on minor 
exertion, early morning headache, daytime fatigue and weight loss may be 
subtle and often overlooked. The classic form of ALS presents with both 
upper motor neuron (UMN) and lower motor neuron (LMN) findings, but it can 
be as in our case limited to LMN only and is referred to as PMA. Compared to 
ALS, patients with PMA are more likely to be males and live longer. 
Management of ALS in all of its forms is supportive, multidisciplinary and 
palliative. Early use of NIPPV in ALS patients prolong survival and improve 
quality of life. Invasive mechanical ventilation, implying the use of an 
endotracheal tube or a tracheostomy may be considered. Patient with bulbar 
dysfunction may need gastrostomy to support nutrition. A FVC of <50% of the 
predicted value has been shown to be associated with poor prognosis. 
Arriving to accurate diagnosis in timely manner is critical for health care 
team to expedited discussion with patient and family about management plan 
and encourage them to consider advanced directives regarding end of life. 
Patients should be provided with a realistic prognostication of the course 
of their disease and in the event of decline of full mechanical ventilation, 
patient and family should be provided with assurance that palliative care 
strategies can control symptoms in the terminal phase of illness.
EMTREE DRUG INDEX TERMS
  oxygen; receptor antibody; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chronic respiratory failure; intensive care; male; society; 
EMTREE MEDICAL INDEX TERMS
  abnormal respiratory sound; amyotrophic lateral sclerosis; ankle; arterial gas; artificial ventilation; assisted ventilation; auscultation; blood gas analysis; body weight loss; brain stem; breathing; bulbar paralysis; chronic obstructive lung disease; clinical feature; comfort; computer assisted tomography; death; degeneration; degenerative disease; diagnosis; diseases; dyspnea; electromyography; endotracheal tube; exercise; extubation; fasciculation; fatigue; gastrostomy; headache; health care; hospital; human; hypercapnia; lethargy; lung disease; lung function test; mental health; motoneuron; muscle; nutrition; palliative therapy; paralysis; patient; pH; physical examination; primary motor cortex; prognosis; progressive muscular atrophy; quality of life; respiratory distress; respiratory failure; sleep disordered breathing; slurred speech; spinal cord; stomach tube; survival; tachycardia; thorax; thorax radiography; tongue; trachea; tracheostomy; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71534365
DOI
  10.1097/01.ccm.0000440425.24346.23
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000440425.24346.23
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000440425.24346.23&atitle=Acute+on+chronic+respiratory+failure+in+79+year+old+male&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=41&issue=12&spage=A303&epage=A304&aulast=Patel&aufirst=Darshan&auinit=D.&aufull=Patel+D.&coden=&isbn=&pages=A303-A304&date=2013&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 468
TITLE
  Utilization of bioelectrical impedance analysis in the ICU acquired weakness
AUTHOR NAMES
  Chang J.Y.; Kim K.; Han M.-K.; Park S.-H.; Cho Y.J.
AUTHOR ADDRESSES
  (Chang J.Y.; Kim K.; Han M.-K.; Park S.-H.; Cho Y.J.) Seoul National 
University, Bun Dang Hospital, Seong Nam, South Korea.
CORRESPONDENCE ADDRESS
  J.Y. Chang, Seoul National University, Bun Dang Hospital, Seong Nam, South 
Korea.
FULL RECORD ENTRY DATE
  2014-07-22
SOURCE
  Critical Care Medicine (2013) 41:12 SUPPL. 1 (A306). Date of Publication: 
December 2013
VOLUME
  41
ISSUE
  12
FIRST PAGE
  A306
DATE OF PUBLICATION
  December 2013
CONFERENCE NAME
  43rd Critical Care Congress of the Society of Critical Care Medicine, SCCM 
2014
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2014-01-09 to 2014-01-13
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: ICU acquired weakness (ICUAW) is defined as a presence of 
muscle wasting and neuromuscular dysfunction in critically ill patients 
without plausible etiology. ICUAW is associated with increased mortality, 
prolonged mechanical ventilation, and impaired post ICU independent life. 
Bioelectrical impedance analysis (BIA) is an easy, noninvasive method of 
estimating body composition using different electrical impedance of tissue 
components. We have attempted to investigate correlation between serial BIA 
tests and muscle power examinations in the ICUAW case. A 39-year old patient 
with a history of acute myeloid leukemia on a remission state after 
chemotherapy and allogeneic peripheral blood stem cell transplantation, was 
admitted with general weakness and immobilization due to thoracic spine 
compression fracture. Respiratory failure with hypoxemia and hypercapnia was 
developed due to hospital acquired pneumonia on the right lower lobe and 
recurrent left pneumothorax. He was transferred to medical ICU and 
mechanical ventilator was applied. Chest tube was inserted and intravenous 
antibiotics were administered. After proper management for 2 weeks, He was 
recovered from pneumonia and pneumothorax, but muscle power became weakened 
and atrophy progressed during the ICU stay. He was not able to sit on a bed 
for himself. Weaning from mechanical ventilator had failed, tracheostomy was 
done and BIPAP was applied instead. Muscle power grades of all extremities 
at ICU admission were IV. At 9th day of ICU stay, the motor power of 
shoulder abduction, adduction of right and left was IV/IV-, IV/IV-, elbow 
flexion and extension IV-/IV-, IV/IV, wrist flexion and extension, hand grip 
were all IV on medical research council (MRC) scale. The motor power of hip 
flexion, extension was III/IV-, III/IV, Knee flexion, extension IV-/ IV-, 
IV/ IV, ankle dorsiflexion, plantar flexion III/IV, III/IV. Considering the 
weakness was developed after the onset of pneumonia, generalized involving 
both proximal and distal muscles, MRC sum score below 48, and dependency on 
mechanical ventilation, the diagnosis was compatible with ICUAW. The BIA 
results of skeletal muscle mass (SMM) and Fat free mass (FFM, listed in 
brackets) was 16kg (32.1kg) at 3rd day of ICU stay, continuous declined to 
14.6kg (30.1kg) at 9th day of ICU stay. Appendicular muscle mass of right 
arm, left arm, right leg and left leg at 3rd day after ICU admission were 
0.8, 0.9, 6.2, 6.5kg each. After 9th day of ICU admission, both lower 
extremities muscle mass decreased from to 6.2kg to 5.0kg at right side and 
6.5kg to 5.2kg at left side. Passive range of motion of each joint was 
maintained during the ICU stay to prevent joint contracture. Physical 
therapy including range of motion against resistance (RROM) with cycle 
ergometer and sitting to chair exercise was started at 22th day after ICU 
admission. After two weeks of physical therapy, the muscle strength of 
extremities was slightly improved before physical therapy from grade IV- to 
IV+ in both shoulder adduction and abduction, IV-to IV in right elbow 
flexion and hip extension, IV to IV+ in right wrist flexion, III to IV- in 
both ankle dorsiflexion compared with the result of muscle power examination 
at 9th day. Total SMM and FFM slightly increased from 14.6 to 15.0 and 30.1 
to 30.7kg. Appendicular muscle mass of right arm, left arm, right leg and 
left leg increased from 1.0, 0.9, 5.0, 5.2 to 1.2, 1.0, 5.6, 5.5kg. The 
change of truncal muscle mass was not correlated with that of partial 
pressure of arterial CO2 or ventilatory parameters. As a medical condition 
of the patient was fluctuating, the clinical muscle power after a month was 
not improved and so was the BIA result. The changes of total skeletal and 
appendicular muscle mass were proportional to the clinically detected muscle 
strength. Based on the result, further study is planned to determine whether 
the BIA could predict occurence and clinical course of ICUAW using variable 
BIA parameters.
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  impedance; intensive care; society; weakness; 
EMTREE MEDICAL INDEX TERMS
  abduction; acute myeloid leukemia; adduction; allogeneic peripheral blood stem cell transplantation; ankle; arm; artificial ventilation; atrophy; bicycle ergometer; body composition; chemotherapy; chest tube; compression fracture; critically ill patient; diagnosis; disease course; elbow flexion; etiology; examination; exercise; fat free mass; hand grip; hip; hospital acquired pneumonia; human; hypercapnia; hypoxemia; immobilization; joint contracture; knee function; leg; mechanical ventilator; medical research; mortality; muscle; muscle atrophy; muscle mass; muscle strength; neuromuscular disease; non invasive procedure; parameters; patient; physiotherapy; pneumonia; pneumothorax; pressure; range of motion; remission; respiratory failure; shoulder; sitting; skeletal muscle; thoracic spine; tissues; tracheostomy; weaning; wrist; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71534372
DOI
  10.1097/01.ccm.0000440432.62464.7a
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000440432.62464.7a
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000440432.62464.7a&atitle=Utilization+of+bioelectrical+impedance+analysis+in+the+ICU+acquired+weakness&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=41&issue=12&spage=A306&epage=&aulast=Chang&aufirst=Jun+Young&auinit=J.Y.&aufull=Chang+J.Y.&coden=&isbn=&pages=A306-&date=2013&auinit1=J&auinitm=Y
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 469
TITLE
  Mechanical ventilation weaning and extubation after spinal cord injury: A 
western trauma association multicenter study
AUTHOR NAMES
  Kornblith L.Z.; Kutcher M.E.; Callcut R.A.; Redick B.J.; Hu C.K.; Cogbill T.H.; Baker C.C.; Shapiro M.L.; Burlew C.C.; Kaups K.L.; DeMoya M.A.; Haan J.M.; Koontz C.H.; Zolin S.J.; Gordy S.D.; Shatz D.V.; Paul D.B.; Cohen M.J.
AUTHOR ADDRESSES
  (Kornblith L.Z.; Kutcher M.E.; Callcut R.A.; Redick B.J.; Cohen M.J.) 
Department of Surgery, University of California San Francisco, San Francisco 
General Hospital, San Francisco, United States.
(Kaups K.L.) Department of Surgery, CommunityRegionalMedical 
Center/University of California San Francisco, Fresno, CA, United States.
(Hu C.K.) Trauma Services, Scottsdale Healthcare Osborn Medical Center, 
Scottsdale, Arizona, United States.
(Cogbill T.H.) Department of Surgery, Gundersen Lutheran Medical Foundation, 
La Crosse, Wisconsin, United States.
(Baker C.C.) Department of Surgery, Virginia Tech Carilion School of 
Medicine, Carilion Roanoke Memorial Hospital, Roanoke, Virginia, United 
States.
(Shapiro M.L.) Division of Trauma, Surgical Critical Care, and AcuteCare 
Surgery, Duke University Medical Center, Durham, North Carolina, United 
States.
(Burlew C.C.) Department of Surgery, Denver Health Medical Center, 
University of Colorado, Denver, CO, United States.
(DeMoya M.A.) Division of Trauma, Emergency Surgery and Surgical Critical 
Care, Massachusetts General Hospital and Harvard Medical School, Boston, 
Massachusetts, United States.
(Haan J.M.) Department of Surgery, Via Christi Regional Medical Center, 
Wichita, Kansas, United States.
(Koontz C.H.) Department of Surgery, New York University Langone Medical 
Center, New York, United States.
(Zolin S.J.) Department of General Surgery and Trauma, University of 
Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States.
(Gordy S.D.) Department of Surgery, Oregon Health Sciences University, 
Portland, Oregon, United States.
(Shatz D.V.) Department of Surgery, University of California, Davis Medical 
Center, Davis, CA, United States.
(Paul D.B.) Department of Surgery, Grant Medical Center, Columbus, Ohio, 
United States.
CORRESPONDENCE ADDRESS
  Department of Surgery, University of California San Francisco, San Francisco 
General Hospital, San Francisco, United States.
AiP/IP ENTRY DATE
  2013-12-18
FULL RECORD ENTRY DATE
  2013-12-26
SOURCE
  Journal of Trauma and Acute Care Surgery (2013) 75:6 (1060-1069). Date of 
Publication: December 2013
VOLUME
  75
ISSUE
  6
FIRST PAGE
  1060
LAST PAGE
  1069
DATE OF PUBLICATION
  December 2013
ISSN
  2163-0755
  2163-0763 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  BACKGROUND: Respiratory failure after acute spinal cord injury (SCI) is well 
recognized, but data defining which patients need long-term ventilator 
support and criteria for weaning and extubation are lacking. We hypothesized 
that many patients with SCI, even those with cervical SCI, can be 
successfully managed without long-term mechanical ventilation and its 
associated morbidity. METHODS: Under the auspices of theWestern Trauma 
Association Multi-Center Trials Group, a retrospective study of patients 
with SCI at 14 major trauma centers was conducted. Comprehensive injury, 
demographic, and outcome data on patients with acute SCI were compiled. The 
primary outcome variable was the need for mechanical ventilation at 
discharge. Secondary outcomes included the use of tracheostomy and 
development of acute lung injury and ventilator-associated pneumonia. 
RESULTS: A total of 360 patients had SCI requiring mechanical ventilation. 
Sixteen patients were excluded for death within the first 2 days of 
hospitalization. Of the 344 patients included, 222 (64.5%) had cervical SCI. 
Notably, 62.6% of the patients with cervical SCI were ventilator free by 
discharge.One hundred forty-nine patients (43.3%) underwent tracheostomy, 
and 53.7% of them were successfully weaned from the ventilator, compared 
with an 85.6% success rate among those with no tracheostomy (p G 0.05). 
Patients who underwent tracheostomy had significantly higher rates of 
ventilator-associated pneumonia (61.1% vs. 20.5%, p < 0.05) and acute lung 
injury (12.8% vs. 3.6%, p < 0.05) and fewer ventilator-free days (1 vs. 24 p 
< 0.05). When controlled for injury severity, thoracic injury, and 
respiratory comorbidities, tracheostomy after cervical SCI was an 
independent predictor of ventilator dependence with an associated 14-fold 
higher likelihood of prolonged mechanical ventilation (odds ratio, 14.1; 95% 
confidence interval, 2.78-71.67; p < 0.05). CONCLUSION: While many patients 
with SCI require short-term mechanical ventilation, the majority can be 
successfully weaned before discharge. In patients with SCI, tracheostomy is 
associated with major morbidity, and its use, especially among patients with 
cervical SCI, deserves further study. © 2013 by Lippincott Williams & 
Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury; respiratory failure (complication, therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  acute lung injury (complication); adult; aged; cause of death; comorbidity; conference paper; confidence interval; extubation; female; human; injury severity; major clinical study; male; morbidity; multicenter study; priority journal; retrospective study; tracheostomy; treatment outcome; United States; ventilator associated pneumonia (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013781277
MEDLINE PMID
  24256682 (http://www.ncbi.nlm.nih.gov/pubmed/24256682)
PUI
  L370445733
DOI
  10.1097/TA.0b013e3182a74a5b
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e3182a74a5b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630755&id=doi:10.1097%2FTA.0b013e3182a74a5b&atitle=Mechanical+ventilation+weaning+and+extubation+after+spinal+cord+injury%3A+A+western+trauma+association+multicenter+study&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=75&issue=6&spage=1060&epage=1069&aulast=Kornblith&aufirst=Lucy+Z.&auinit=L.Z.&aufull=Kornblith+L.Z.&coden=&isbn=&pages=1060-1069&date=2013&auinit1=L&auinitm=Z
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 470
TITLE
  Endovascular versus open elephant trunk completion for extensive aortic 
disease
AUTHOR NAMES
  Roselli E.E.; Subramanian S.; Sun Z.; Idrees J.; Nowicki E.; Blackstone E.H.; Greenberg R.K.; Svensson L.G.; Lytle B.W.
AUTHOR ADDRESSES
  (Roselli E.E., roselle@ccf.org; Idrees J.; Blackstone E.H.; Greenberg R.K.; 
Svensson L.G.; Lytle B.W.) Aorta Center, Department of Thoracic and 
Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Ave, J4-1, Cleveland, 
OH 44195, United States.
(Greenberg R.K.) Department of Vascular Surgery, Heart and Vascular 
Institute, Cleveland Clinic, Cleveland, OH, United States.
(Sun Z.; Nowicki E.; Blackstone E.H.) Quantitative Health Sciences, 
Cleveland Clinic, Cleveland, OH, United States.
(Subramanian S.) University of Arizona Medical Center, Tucson AZ, United 
States.
CORRESPONDENCE ADDRESS
  E.E. Roselli, Aorta Center, Department of Thoracic and Cardiovascular 
Surgery, Cleveland Clinic, 9500 Euclid Ave, J4-1, Cleveland, OH 44195, 
United States. Email: roselle@ccf.org
AiP/IP ENTRY DATE
  2013-09-30
FULL RECORD ENTRY DATE
  2013-11-28
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2013) 146:6 (1408-1416). 
Date of Publication: December 2013
VOLUME
  146
ISSUE
  6
FIRST PAGE
  1408
LAST PAGE
  1416
DATE OF PUBLICATION
  December 2013
ISSN
  0022-5223
  1097-685X (electronic)
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  Objectives To compare the outcomes between patients undergoing endovascular 
(EEC) or open (OEC) approaches to second-stage elephant trunk completion 
(EC). Methods From 1993 to 2010, 225 patients underwent second-stage EC 
(EEC, n = 92; OEC, n = 133). Propensity matching was performed for a fair 
comparison. Results The EEC patients were older, more likely to have atrial 
fibrillation, and had a smaller proximal aorta. The 30-day mortality was 
6.2% (6.5% EEC vs 6% OEC, P =.88). No difference was found in bleeding 
(8.8%), stroke (3%), renal failure (4%), or spinal cord injury (4%); 
however, the OEC patients required tracheostomy more often (10 vs 1, P 
=.014). Survival after second-stage EC at 6 months and 1 and 5 years was 
91%, 90%, and 77%, respectively. Survival and major morbidity did not differ 
after matching (44 pairs). However, the EEC group had shorter stays (9.9 ± 
13 vs 13 ± 9 days, P <.0001) and received less blood (3 ± 8 vs 6 ± 8 U, P 
=.0001) than did the OEC group. This was maintained after matching. During 
follow-up, 32 endoleaks (3 type I, 27 type II, 2 type III) occurred; 26 
(28%) EEC and 13 of 76 (17%) OEC patients underwent reoperation. The 
approach was not related to the risk of death in either hazard phase, but a 
larger descending diameter predicted a greater risk in the early phase. 
Conclusions Death and complications occur similarly after OEC or EEC. The 
early toll might be greater after OEC, at the cost of reintervention for 
EEC. EEC expands the options to older patients and allows for earlier 
completion. Second-stage repair should not be delayed, and all patients 
require lifelong imaging surveillance. Copyright © 2013 by The American 
Association for Thoracic Surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic disease (surgery); endovascular elephant trunk completion; endovascular surgery; open elephant trunk completion; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; atrial fibrillation; bleeding (complication); cardiopulmonary bypass; cerebrovascular accident (complication); endoleak (complication); female; follow up; hemiplegia (complication); human; intermethod comparison; kidney failure (complication); long term survival; major clinical study; male; morbidity; mortality; priority journal; reoperation; respiratory failure (complication); thoracotomy; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013732463
MEDLINE PMID
  24075563 (http://www.ncbi.nlm.nih.gov/pubmed/24075563)
PUI
  L52790977
DOI
  10.1016/j.jtcvs.2013.07.070
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2013.07.070
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225223&id=doi:10.1016%2Fj.jtcvs.2013.07.070&atitle=Endovascular+versus+open+elephant+trunk+completion+for+extensive+aortic+disease&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=146&issue=6&spage=1408&epage=1416&aulast=Roselli&aufirst=Eric+E.&auinit=E.E.&aufull=Roselli+E.E.&coden=JTCSA&isbn=&pages=1408-1416&date=2013&auinit1=E&auinitm=E
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 471
TITLE
  Case report of Os odontoideum causing Ondine's curse
AUTHOR NAMES
  Campbell E.; Brown J.
AUTHOR ADDRESSES
  (Campbell E., EmerCampbell@doctors.org.uk; Brown J.) Department of 
Neurosurgery, Institute of Neurological Sciences, Southern General Hospital, 
1345, Govan Road, Glasgow, G51 4TF, United Kingdom.
CORRESPONDENCE ADDRESS
  E. Campbell, Department of Neurosurgery, Institute of Neurological Sciences, 
Southern General Hospital, 1345, Govan Road, Glasgow, G51 4TF, United 
Kingdom. Email: EmerCampbell@doctors.org.uk
AiP/IP ENTRY DATE
  2013-12-13
FULL RECORD ENTRY DATE
  2013-12-18
SOURCE
  British Journal of Neurosurgery (2013) 27:6 (836-837). Date of Publication: 
December 2013
VOLUME
  27
ISSUE
  6
FIRST PAGE
  836
LAST PAGE
  837
DATE OF PUBLICATION
  December 2013
ISSN
  0268-8697
  1360-046X (electronic)
BOOK PUBLISHER
  Informa Healthcare, 69-77 Paul Street, London, United Kingdom.
ABSTRACT
  Ondine's curse or central hypoventilation syndrome is most common congenital 
disorder which is diagnosed in infancy. In the majority of cases, no 
structural abnormality is identified. We describe the case of an 18-year-old 
patient who presented with Ondine's curse secondary to an os odontoideum. © 
2013 The Neurosurgical Foundation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  congenital central hypoventilation syndrome (diagnosis, rehabilitation, 
surgery); odontoid process; 
EMTREE MEDICAL INDEX TERMS
  adult; air conditioning; ambient air; apnea; arterial gas; article; atrophy; breathing; breathing pattern; case report; cervical spinal cord; cervical spine; consciousness disorder; cyanosis; daytime somnolence; dyspnea; falling; female; foramen magnum; human; hypoxia; inspiratory capacity; intubation; nuclear magnetic resonance imaging; oxygen saturation; pneumonia; priority journal; rehabilitation; respiratory failure; sedation; spinal cord compression; spine fusion; tracheostomy; voluntary movement; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013771152
MEDLINE PMID
  23672469 (http://www.ncbi.nlm.nih.gov/pubmed/23672469)
PUI
  L370412807
DOI
  10.3109/02688697.2013.795520
FULL TEXT LINK
  http://dx.doi.org/10.3109/02688697.2013.795520
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02688697&id=doi:10.3109%2F02688697.2013.795520&atitle=Case+report+of+Os+odontoideum+causing+Ondine%27s+curse&stitle=Br.+J.+Neurosurg.&title=British+Journal+of+Neurosurgery&volume=27&issue=6&spage=836&epage=837&aulast=Campbell&aufirst=Emer&auinit=E.&aufull=Campbell+E.&coden=BJNEE&isbn=&pages=836-837&date=2013&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 472
TITLE
  Editorial Critique
AUTHOR NAMES
  Wyrzykowski A.D.
AUTHOR ADDRESSES
  (Wyrzykowski A.D.) Emory University Department of Surgery, Division of 
Trauma and Surgical Critical Care, Atlanta, GA, United States.
CORRESPONDENCE ADDRESS
  A.D. Wyrzykowski, Emory University Department of Surgery, Division of Trauma 
and Surgical Critical Care, Atlanta, GA, United States.
FULL RECORD ENTRY DATE
  2013-12-18
SOURCE
  Journal of Trauma and Acute Care Surgery (2013) 75:6 (1069-1070). Date of 
Publication: December 2013
VOLUME
  75
ISSUE
  6
FIRST PAGE
  1069
LAST PAGE
  1070
DATE OF PUBLICATION
  December 2013
ISSN
  2163-0755
  2163-0763 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  cervical spine injury; human; injury severity; note; priority journal; ventilator; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013781278
PUI
  L370445734
DOI
  10.1097/TA.0b013e3182a74a5b
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e3182a74a5b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630755&id=doi:10.1097%2FTA.0b013e3182a74a5b&atitle=Editorial+Critique&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=75&issue=6&spage=1069&epage=1070&aulast=Wyrzykowski&aufirst=Amy+D.&auinit=A.D.&aufull=Wyrzykowski+A.D.&coden=&isbn=&pages=1069-1070&date=2013&auinit1=A&auinitm=D
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 473
TITLE
  Does laminoplasty really improve neurological status in patients with 
cervical spinal cord injury without bone and disc injury? A prospective 
study about neurological recovery and early complications
AUTHOR NAMES
  Mazaki T.; Ito Y.; Sugimoto Y.; Koshimune K.; Tanaka M.; Ozaki T.
AUTHOR ADDRESSES
  (Mazaki T., tetsuromazaki@yahoo.co.jp; Tanaka M.; Ozaki T.) Department of 
Orthopaedic Surgery, Okayama University, Graduate School of Medicine, 
Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 
700-8558, Japan.
(Ito Y.; Sugimoto Y.; Koshimune K.) Department of Orthopaedic Surgery, Kobe 
Red Cross Hospital, 1-3-1 Wakinohamakaigandori, Chuo-ku, Kobe, Japan.
CORRESPONDENCE ADDRESS
  T. Mazaki, Department of Orthopaedic Surgery, Okayama University, Graduate 
School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 
Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Email: 
tetsuromazaki@yahoo.co.jp
AiP/IP ENTRY DATE
  2013-07-19
FULL RECORD ENTRY DATE
  2013-11-13
SOURCE
  Archives of Orthopaedic and Trauma Surgery (2013) 133:10 (1401-1405). Date 
of Publication: 2013
VOLUME
  133
ISSUE
  10
FIRST PAGE
  1401
LAST PAGE
  1405
DATE OF PUBLICATION
  2013
ISSN
  0936-8051
  1434-3916 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Purpose: Cervical spinal cord injury without bone and disc injury in 
patients with spinal cord compression is a fairly common problem in Japan. 
Because elderly Japanese population tend to have cervical spinal canal 
stenosis. However, there has been no consensus in the treatment of these 
patients. We conducted a prospective study to evaluate treatment outcomes 
and complications of these patients. Methods: Twenty-five patients had been 
enrolled in this study. Patients who had paralysis of ASIA impairment scale 
(AIS) A, B or C were included. With each new patient, we alternated whether 
he/she received surgical treatment (group S) or conservative treatment 
(group C). Eleven patients were assigned to each group. We compared the two 
groups' courses of treatment and complications by evaluating their 
neurological symptoms using the AIS and ASIA motor score (MS) documenting 
them at the time of injury and 3 months later. Results: The majority of 
clinical paralysis was found at the C3/4 level for both the groups. 
According to complications, there were seven urinary tract infections and 
four pneumonias in group S and one urinary tract infection and three 
pneumonias in group C. Both groups had an average MS of 42 at the time of 
injury. Three months later, the average MSs were 59 points in group S and 65 
points in group C. Conclusions: In the present study, we found no 
significant difference in paralysis improvement between surgical and 
conservative treatment, although we observed a higher frequency of 
complications with surgery. © 2013 Springer-Verlag Berlin Heidelberg.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); laminoplasty; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; American Spinal Injury Association impairment scale; article; clinical article; conservative treatment; controlled clinical trial; controlled study; female; human; male; paralysis; pneumonia (complication); priority journal; prospective study; tracheotomy; urinary tract infection (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013638372
MEDLINE PMID
  23860672 (http://www.ncbi.nlm.nih.gov/pubmed/23860672)
PUI
  L52685130
DOI
  10.1007/s00402-013-1810-x
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00402-013-1810-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09368051&id=doi:10.1007%2Fs00402-013-1810-x&atitle=Does+laminoplasty+really+improve+neurological+status+in+patients+with+cervical+spinal+cord+injury+without+bone+and+disc+injury%3F+A+prospective+study+about+neurological+recovery+and+early+complications&stitle=Arch.+Orthop.+Trauma+Surg.&title=Archives+of+Orthopaedic+and+Trauma+Surgery&volume=133&issue=10&spage=1401&epage=1405&aulast=Mazaki&aufirst=Tetsuro&auinit=T.&aufull=Mazaki+T.&coden=AOTSE&isbn=&pages=1401-1405&date=2013&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 474
TITLE
  Rash decisions-dermatological manifestations preceding a progressive 
neurological syndrome
AUTHOR NAMES
  Doherty G.; Vincent A.; Cox A.
AUTHOR ADDRESSES
  (Doherty G.; Vincent A.; Cox A.) Addenbrooke's Hospital, Cambridge; 
Weatherall Institute of Molecular Medicine, Oxford
CORRESPONDENCE ADDRESS
  G. Doherty,
FULL RECORD ENTRY DATE
  2014-04-11
SOURCE
  Journal of Neurology, Neurosurgery and Psychiatry (2013) 84:11. Date of 
Publication: November 2013
VOLUME
  84
ISSUE
  11
DATE OF PUBLICATION
  November 2013
CONFERENCE NAME
  Association of British Neurologists, ABN Joint Meeting with the Royal 
College of Physicians, RCP 2013
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2013-10-23 to 2013-10-24
ISSN
  0022-3050
BOOK PUBLISHER
  BMJ Publishing Group
ABSTRACT
  We describe the case of a 72 year old woman who presented with sequential 
cranial nerve palsies preceded by irritation, pain and a vesicular rash in 
the sensory distributions of the affected nerves. She had signs and symptoms 
suggestive of aphagia and Ramsey-Hunt syndrome. Further vesicular eruptions 
roughly obeying dermatomal boundaries on the limbs and trunk were observed. 
She was initially thought to have disseminated VZV/ HZV infection and was 
commenced on IV aciclovir. Investigations seeking evidence for viral 
particles in skin lesions and CSF, and for evidence of immunosuppression or 
malignancy, were all negative. Between days 35 and 40 she developed 
hypertension, seizures, a left facial nerve palsy and encephalopathy. This 
was complicated by a pneumonia requiring invasive ventilation on intensive 
care. She developed an itchy maculopapular rash with vesiculation of all 
four limbs. On day 66 she developed truncal and limb rigidity, which became 
extreme over two weeks, and was associated with pyramidal weakness. The rash 
was biopsied demonstrating a leucocytoclastic vasculitis. At the nadir of 
her illness she was encephalopathic, tracheostomy-and NG feeding- dependent, 
quadriparetic and bedbound due to severe rigidity (leading rapidly to 
Achilles tendon contractures). She was found to be glycine receptor (GlyR) 
antibody positive, without antibodies against amphiphysin or GAD65. She was 
initially treated with a combination of corticosteroids and intravenous 
immunoglobulin (IVIG), resulting in resolution of her cranial nerve palsies, 
and a reduction in her rigidity and rash. Imaging using CT, PET, USS and 
mammography was undertaken to exclude malignancy-associated antibody 
production. MRI imaging of the brain and spinal cord was essentially normal. 
CSF analysis demonstrated only the presence of intrathecal IgG synthesis. 
Her treatment and rehabilitation continues. This case adds to the small 
number of reports in the literature of a Stiff Person Syndrome (SPS) plus 
syndrome considered to be caused by antibodies directed against the 
extracellular GlyR target on the synaptic neuronal surface.(1 2) Our case 
demonstrates further clinical variability within this unusual disorder. The 
GlyR is expressed in skin, and the presence of zoster-like dermatological 
lesions may provide a clinical clue as to the underlying aetiology in 
similar cases. Many of the features seen in this case have been previously 
described, however in this case the features emerged sequentially with 
rigidity, the cardinal feature of this group of diseases, emerging last. The 
clinical manifestations of the cases of GlyR antibody associated SPS plus 
disease described, closely resemble the clinical manifestations of genetic 
mutations of GlyR subunits and associated proteins, and of poisoning with 
the GlyR antagonist strychnine. This adds to the evidence that these 
antibodies play a direct role in the pathogenesis of disease, and that the 
use of immunosuppressive treatment is justified. Indeed our patient has made 
a substantial recovery with aggressive immunotherapy. To date no associated 
malignancy has been associated with GlyR antibody-mediated SPS plus disease, 
and our case supports these findings.
EMTREE DRUG INDEX TERMS
  aciclovir; amphiphysin; antibody; corticosteroid; glycine receptor; immunoglobulin; immunoglobulin G; protein; receptor antibody; strychnine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  college; human; neurologic disease; neurologist; physician; rash; 
EMTREE MEDICAL INDEX TERMS
  achilles tendon; air conditioning; antibody production; aphagia; brain; brain disease; cerebrospinal fluid; cranial nerve paralysis; diseases; etiology; facial nerve paralysis; feeding; female; herpes zoster oticus; hypertension; imaging; immobility; immunosuppressive treatment; immunotherapy; infection; intensive care; intoxication; intrathecal drug administration; limb; maculopapular rash; mammography; mutation; nerve; nuclear magnetic resonance imaging; pain; pathogenesis; patient; physical disease by body function; pneumonia; rehabilitation; rigidity; seizure; skin; skin defect; spinal cord; stiff man syndrome; synthesis; tendon contracture; tracheostomy; vasculitis; vesicular rash; virus particle; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71399494
DOI
  10.1136/jnnp-2013-306573.40
FULL TEXT LINK
  http://dx.doi.org/10.1136/jnnp-2013-306573.40
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223050&id=doi:10.1136%2Fjnnp-2013-306573.40&atitle=Rash+decisions-dermatological+manifestations+preceding+a+progressive+neurological+syndrome&stitle=J.+Neurol.+Neurosurg.+Psychiatry&title=Journal+of+Neurology%2C+Neurosurgery+and+Psychiatry&volume=84&issue=11&spage=&epage=&aulast=Doherty&aufirst=Gary&auinit=G.&aufull=Doherty+G.&coden=&isbn=&pages=-&date=2013&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 475
TITLE
  Infection rate after transoral approach for the upper cervical spine
AUTHOR NAMES
  Mosafer A.; Shousha M.; Böhm H.
AUTHOR ADDRESSES
  (Mosafer A.; Shousha M.; Böhm H.) Zentralklinik Bad Berka, 
Wirbelsäulenchirurgie, Bad Berka, Germany.
CORRESPONDENCE ADDRESS
  A. Mosafer, Zentralklinik Bad Berka, Wirbelsäulenchirurgie, Bad Berka, 
Germany.
FULL RECORD ENTRY DATE
  2014-01-15
SOURCE
  European Spine Journal (2013) 22:11 (2586-2587). Date of Publication: 
November 2013
VOLUME
  22
ISSUE
  11
FIRST PAGE
  2586
LAST PAGE
  2587
DATE OF PUBLICATION
  November 2013
CONFERENCE NAME
  8. Deutscher Wirbelsaulenkongress Jahrestagung der Deutschen 
Wirbelsaulengesellschaft
CONFERENCE LOCATION
  Frankfurt am Main, Germany
CONFERENCE DATE
  2013-12-05 to 2013-12-07
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction: The upper cervical spine is classically approached from 
anterior via the transoral-transpharyngeal approach. However, this is still 
not in common use due to concerns about exposure and infection. The purpose 
of this study is to analyse the incidence and risk factors of local 
infection after transoral approach for lesions in the upper cervical spine. 
Material and Methods: In the time between 1994 and 2012, the transoral 
approach to the upper cervical spine has been used in 139 patients in our 
institution. The clinical and radiological data of these patients were 
retrospectively analysed. The mean age at presentation was 53.6 years 
(range: 5 to 87 years), and more than half of the patients were males 
(58.3%). The majority of cases were suffering from rheumatic diseases 
(43.9%), while tumour destruction was the indication for surgery in 23.7% of 
the cases. 23% had fracture of the upper cervical spine and spondylitis was 
found in 7 patients (5%). The technique applied involved an anterior 
transoral approach without tracheotomy using a flexible oral endotracheal 
tube. Exposure was obtained using a selfretaining mouth retractor by means 
of a midline incision of the posterior wall of the pharynx. In no case was 
it necessary to divide the mandible, tongue, soft palate, or uvula. The most 
common procedure was dens resection (58.3%), and a metal implant was used in 
47 cases (33.8%), mostly in cases with tumours and fractures. The mean 
follow-up period was 4.5 years. Results: Analysis of the records revealed 
that 16/139 patients (11.5%) underwent a second transoral surgery. Three 
cases underwent a planned removal of implant after fracture union. In the 
remaining 13 /139 patients (9.35%), the second transoral surgery was due to 
a complication. In seven patients (5%), the revision was due to a mechanical 
or neurological insult in the early postoperative period with immediate good 
results. One patient with plasmacytoma C2 presented with recurrence and 
extrusion of the implanted cage one year postoperatively necessitating 
plastic coverage of the pharyngeal wall. In the remaining five patients 
(3.59%), infection of the pharyngeal wound did occur. The risk factors and 
management of this art of complication were evaluated. Discussion and 
conclusion: The incidence of postoperative infection after transoral surgery 
in this series was 3.59%. Age and gender were not statistically significant 
risk factors for infection. No postoperative infection occurred in patients 
presenting with spondylitis. Infection occurred exclusively in rheumatic and 
tumour cases. The presentation was mostly in the first three months. A 
single patient with cage reconstruction after giant cell tumour C2 presented 
with a late infection five years postoperatively. Debridement and primary 
closure was possible in two patients, while flap coverage of the pharyngeal 
wall was necessary in three patients. The presence of implant did not have a 
statistically significant effect on the occurrence of infection. However, 
infection in the presence of titanium cage mostly necessitated flap coverage 
of the pharyngeal wall after removal of the cage.
EMTREE DRUG INDEX TERMS
  metal; plastic; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; infection rate; 
EMTREE MEDICAL INDEX TERMS
  debridement; endotracheal tube; exposure; follow up; fracture; fracture healing; gender; giant cell tumor; human; implant; incision; infection; male; mandible; neoplasm; odontoid process; palate; patient; pharynx; plasmacytoma; postoperative infection; postoperative period; procedures; retractor; rheumatic disease; risk factor; soft palate; spondylitis; surgery; titanium cage; tongue; tracheotomy; wound; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71283579
DOI
  10.1007/s00586-013-3050-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-013-3050-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-013-3050-8&atitle=Infection+rate+after+transoral+approach+for+the+upper+cervical+spine&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=22&issue=11&spage=2586&epage=2587&aulast=Mosafer&aufirst=A.&auinit=A.&aufull=Mosafer+A.&coden=&isbn=&pages=2586-2587&date=2013&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 476
TITLE
  Challenges in pediatric spine surgery: Surgical management of dens aplasia 
and craniocervical instability in a sixmonths-old child - A Case Report
AUTHOR NAMES
  Krishnan R.; Mochert J.; Schumacher M.
AUTHOR ADDRESSES
  (Krishnan R.; Mochert J.; Schumacher M.) Sheikh Khalifa Medical City, 
Neurosurgery, Abu Dhabi, United Arab Emirates.
CORRESPONDENCE ADDRESS
  R. Krishnan, Sheikh Khalifa Medical City, Neurosurgery, Abu Dhabi, United 
Arab Emirates.
FULL RECORD ENTRY DATE
  2014-01-15
SOURCE
  European Spine Journal (2013) 22:11 (2657). Date of Publication: November 
2013
VOLUME
  22
ISSUE
  11
FIRST PAGE
  2657
DATE OF PUBLICATION
  November 2013
CONFERENCE NAME
  8. Deutscher Wirbelsaulenkongress Jahrestagung der Deutschen 
Wirbelsaulengesellschaft
CONFERENCE LOCATION
  Frankfurt am Main, Germany
CONFERENCE DATE
  2013-12-05 to 2013-12-07
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction: We report a case of a 6-months-old boy who presented to our 
hospital with progressive paraparesis and breathing disorder due to aplasia 
of the dens caused by a form of Morquio syndrome with instability of the 
craniocervical junction due to aplasia of the dens. Material/Methods: The 
patient is a full-term firstborn of first degree cousins. At six months age 
he was readmitted with altered level of consciousness and convulsions. He 
was intubated. CT scan and LP were unremarkable. After repeated extubation 
failures a tracheostomy was done. Clinically he featured central hypotonia 
with poor head control, clonus of lower limbs and inability to roll over. No 
dysmorphic features. No organomegaly. MRI showed anomaly of C1 and C2 with 
hypoplastic atlas and axis, displacement of C1 and C2 posteriorly with 
atlantoaxial subluxation causing compression of the cord and subsequent 
myelomalacia (Fig. 1) and CSF circulation disorder with bilateral hygroma. 
Immobilization with a custom SOMI brace was done and the boy was taken to 
surgery. Rib grafting with non resorbable sutures and fusion of occiput to 
C2 was done with intraoperative 3D imaging (O-Arm). The further course was 
complicated after graft dislocation due to immobilization failure on the 
18th postoperative day. Revision surgery was done for him with additional 
rib graft interposition and fusion of C0 to C3, further resection of the 
ring of C1 and decompression. Postoperative immobilization was done with 
improved custom brace but failed again due to severe pressure sores on the 
head and neck with super-infection. Daily wound care including surgical 
debridement and VAC of the deep skin lesions was done by an 
interdisciplinary team for 8 weeks. After healing of the skin lesions, 
sedation was stopped and the boy was slowly weaned from ventilation and 
mobilized in a soft collar. Results: The patients neurological deficits 
slowly recovered and the postoperative images showed a good correction of 
the craniocervical alignment and improvement of the CSF circulation 
disorder. Follow up six months after the surgery showed good clinical and 
radiological results. (Figure 2). Conclusion: The unstable craniocervical 
junction of the immature and dysplastic spine in the very young is a 
challenging situation. In this case surgery was indicated for the 
progressive neurological deterioration to decompress and stabilize the 
craniocervical junction. The severe complications in this case due to 
failure of postoperative immobilization were only manageable with a 
multidisciplinary team. To our knowledge this is the first technical report 
giving detailed information about the operative approach to the dysmorphic 
and immature craniocervical junction and the management of postoperative 
complications due to failure of immobilization, which is a challenge in 
these toddlers. (Figure presented).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aplasia; case report; child; human; odontoid process; spine surgery; surgery; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; arm; atlantoaxial subluxation; boy; brace; breathing disorder; cerebrospinal fluid; cerebrospinal fluid circulation disorder; clonus; compression; computer assisted tomography; consciousness; convulsion; debridement; decompression; decubitus; deterioration; extubation; follow up; healing; hospital; hygroma; imaging; immobilization; leg; male; Morquio syndrome; muscle hypotonia; neck; nuclear magnetic resonance imaging; paraplegia; patient; postoperative complication; rib; rib graft; sedation; skin defect; spine; superinfection; suture; toddler; tracheostomy; wound care; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71283743
DOI
  10.1007/s00586-013-3050-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-013-3050-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-013-3050-8&atitle=Challenges+in+pediatric+spine+surgery%3A+Surgical+management+of+dens+aplasia+and+craniocervical+instability+in+a+sixmonths-old+child+-+A+Case+Report&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=22&issue=11&spage=2657&epage=&aulast=Krishnan&aufirst=R.&auinit=R.&aufull=Krishnan+R.&coden=&isbn=&pages=2657-&date=2013&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 477
TITLE
  Surgical treatment and perioperative complications in patients with 
ankylosing spondylitis spine fractures
AUTHOR NAMES
  Török E.; Gempt J.; Meyer B.; Ryang Y.-M.
AUTHOR ADDRESSES
  (Török E.; Gempt J.; Meyer B.; Ryang Y.-M.) Klinikum Rechts der Isar, 
Neurochirurgische Klinik und Poliklinik, München, Germany.
CORRESPONDENCE ADDRESS
  E. Török, Klinikum Rechts der Isar, Neurochirurgische Klinik und Poliklinik, 
München, Germany.
FULL RECORD ENTRY DATE
  2014-01-15
SOURCE
  European Spine Journal (2013) 22:11 (2619-2620). Date of Publication: 
November 2013
VOLUME
  22
ISSUE
  11
FIRST PAGE
  2619
LAST PAGE
  2620
DATE OF PUBLICATION
  November 2013
CONFERENCE NAME
  8. Deutscher Wirbelsaulenkongress Jahrestagung der Deutschen 
Wirbelsaulengesellschaft
CONFERENCE LOCATION
  Frankfurt am Main, Germany
CONFERENCE DATE
  2013-12-05 to 2013-12-07
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Objective: Spine fractures often occur in patients with ankylosing 
spondylitis caused by minor trauma. Due to the low prevalence of the 
pathology, only few series are published and treatment guidelines are 
missing. Methods: We retrospectively reviewed our clinical database for 
pats. suffering from ankylosing spondylitis who underwent surgical treatment 
for spine fractures between 03/2008 and 05/2013. Surgical time, 
hospital-/ICU-stay, pre- and postop. neurological symptoms, co-morbidities, 
perioperative complications and surgical strategy were assessed. Results: 17 
pts (10 m /1 f; mean age 74 yrs, range 47 - 90) were operated for traumatic 
Bechterew fractures (10 cervical, 6 thoracic, 1 lumbar) in a total of 34 
surgeries with a mean operation time of 155 ± 58 min (60 - 309). 14 (82%) 
pats. suffered from more than 1 relevant co-morbidity prior to trauma. Mean 
hospital stay was 26 ± 17 d (6 - 70). 10 (59 %) pats. needed ICU treatment 
(mean stay 13 ± 17 d, range 1 - 51) due to medical deterioration (6 x 
pneumonia, 2 x cardiac arrest 1 x cement embolism, 2x sepsis, 2 x kidney 
failure,1 x postoperative agitation). There were different operating 
strategies for cervical spine fractures: In 9/10 cases a 360 ° fusion was 
applied (5 x anterior - posterior, 4 x post. - ant.). In 2 cases surgery was 
realized 1-staged, in 7 cases 2-staged with a mean interval of 5 ± 3 d (1 - 
10). 1 pat. received mere dorsal instrumentation. Preexisting poor medical 
condition and clinical deterioration obviated a secondary ventral procedure. 
5/7 (71 %) of the pats. with thoracic / lumbar fractures received a 360° 
fusion with primary posterior stabilization with or w/o laminectomy and 
secondary ventral corpectomy during the same hospital stay. 2 pats. received 
mere percutaneous posterior instrumentation. 8 pats. (47 %) had preoperative 
neurological deficits of whom 2/8 pats. improved, 6/8 pats. were unchanged 
postop. 3 severe intraop. complications occurred (1 successful reanimation, 
1 cement embolism, 1 VA-dissection w/o neurological sequelae). There were 2 
mild / moderate intraop. complications (1 durotomy, 1 rod malposition). 3 
pats. had revision surgeries for superficial wound infection, 
screw-loosening 3 months after the first operation and for early implant 
failure 24 hrs after ACDF with secondary fracture dislocation and permanent 
neurological deterioration. This pat. was immediately revised anteriorly and 
received dorsal instrumentation during the same surgical procedure. 7 (41%) 
pats. experienced medical complications (4 pats.: i.e. pneumonia, kidney 
failure), or neurological deterioration (3 pats.) prior to surgery. These 
pats. had significantly longer hospital- (40 ± 18 d vs. 18 ± 8 d, p < 0.05) 
and ICU-stays (30 ± 16 d vs. 2 ± 3 d, p < 0.05). 27 medical complications 
occurred in 10 pts (59 %): 7 pneumonias, 6 tracheotomy, 5 renal failures, 2 
venous thromboses, 2 pleural effusions, 2 sepsis, 2 cardiac arrest, 1 
urinary tract infection, 1 pneumothorax, 1 stroke, 1 GI-bleeding with 
laparatomy and wound infection. 2 of these pats. (12 %) died during hospital 
stay from severe medical complications. Conclusion: Dorso-ventral spine 
instrumentation for ankylosing spondylitis fractures seem to be the surgical 
strategy of choice in these patients. The interval between trauma and 
surgery and in between 2-staged surgeries should be as brief as possible, as 
the patients are at high risk for neurological or medical deterioration 
prior to surgery resulting in significantly longer hospital- and ICU-stays. 
Surgery-associated complications were rare but the rate of medical 
complications was high in this patient group.
EMTREE DRUG INDEX TERMS
  cement; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis; human; patient; peroperative complication; spine fracture; surgery; 
EMTREE MEDICAL INDEX TERMS
  agitation; ant; bleeding; cerebrovascular accident; cervical spine fracture; data base; deterioration; devices; dissection; embolism; fracture; fracture dislocation; heart arrest; hospital; hospitalization; implant; injury; kidney failure; laminectomy; morbidity; neurologic disease; operation duration; pathology; pleura effusion; pneumonia; pneumothorax; prevalence; procedures; resuscitation; risk; sepsis; spine; surgical technique; tracheotomy; urinary tract infection; vein thrombosis; wound infection; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71283652
DOI
  10.1007/s00586-013-3050-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-013-3050-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-013-3050-8&atitle=Surgical+treatment+and+perioperative+complications+in+patients+with+ankylosing+spondylitis+spine+fractures&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=22&issue=11&spage=2619&epage=2620&aulast=T%C3%B6r%C3%B6k&aufirst=E.&auinit=E.&aufull=T%C3%B6r%C3%B6k+E.&coden=&isbn=&pages=2619-2620&date=2013&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 478
TITLE
  Airway management in cervical spine ankylosing spondylitis: Between a rock 
and a hard place
AUTHOR NAMES
  Eipe N.; Fossey S.; Kingwell S.P.
AUTHOR ADDRESSES
  (Eipe N., neipe@toh.on.ca; Fossey S.; Kingwell S.P.) Department of 
Anesthesiology, The Ottawa Hospital, 1053 Carling Ave, Ottawa, K1Y 4E9, ON, 
Canada.
CORRESPONDENCE ADDRESS
  N. Eipe, Department of Anesthesiology, University of Ottawa, 249C-1053 
Carling Ave, Ottawa, K1Y 4E9, ON, Canada. Email: neipe@toh.on.ca
AiP/IP ENTRY DATE
  2014-01-02
FULL RECORD ENTRY DATE
  2014-02-03
SOURCE
  Indian Journal of Anaesthesia (2013) 57:6 (592-595). Date of Publication: 
November/December 2013
VOLUME
  57
ISSUE
  6
FIRST PAGE
  592
LAST PAGE
  595
DATE OF PUBLICATION
  November/December 2013
ISSN
  0019-5049
BOOK PUBLISHER
  Indian Society of Anaesthetists, Flat No 12/1A K Point, 68-BAPC Roy Road, 
Kolkata, India.
ABSTRACT
  We report the perioperative course of a patient with long standing 
ankylosing spondylitis with severe dysphagia due to large anterior cervical 
syndesmophytes at the level of the epiglottis. He was scheduled to undergo 
anterior cervical decompression and the surgical approach possibly precluded 
an elective pre-operative tracheostomy. We performed a modified awake 
fibreoptic nasal intubation through a split nasopharyngeal airway while 
adequate oxygenation was ensured through a modified nasal trumpet inserted 
in the other nares. We discuss the role of nasal intubations and the use of 
both the modified nasopharyngeal airways we used to facilitate tracheal 
intubation. This modified nasal fibreoptic intubation technique could find 
the application in other patients with cervical spine abnormalities and in 
other anticipated difficult airways.
EMTREE DRUG INDEX TERMS
  lidocaine; sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis (surgery); respiration control; 
EMTREE MEDICAL INDEX TERMS
  aged; article; bronchoscope; capnometry; case report; cervical spine; dysphagia; human; male; nasopharynx airway; nasotracheal intubation; nerve block; osteophyte; spinal cord decompression; tracheostomy; 
CAS REGISTRY NUMBERS
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  sevoflurane (28523-86-6)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013817459
PUI
  L370559196
DOI
  10.4103/0019-5049.123333
FULL TEXT LINK
  http://dx.doi.org/10.4103/0019-5049.123333
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00195049&id=doi:10.4103%2F0019-5049.123333&atitle=Airway+management+in+cervical+spine+ankylosing+spondylitis%3A+Between+a+rock+and+a+hard+place&stitle=Indian+J.+Anaesth.&title=Indian+Journal+of+Anaesthesia&volume=57&issue=6&spage=592&epage=595&aulast=Eipe&aufirst=Naveen&auinit=N.&aufull=Eipe+N.&coden=&isbn=&pages=592-595&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 479
TITLE
  Total aortic arch replacement with the frozen elephant trunk technique: 
10-year follow-up single-centre experience
AUTHOR NAMES
  Ius F.; Fleissner F.; Pichlmaier M.; Karck M.; Martens A.; Haverich A.; Shrestha M.
AUTHOR ADDRESSES
  (Ius F.; Fleissner F.; Pichlmaier M.; Karck M.; Martens A.; Haverich A.; 
Shrestha M., shrestha.malakh.lal@mh-hannover.de) Department of 
Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical 
School, Hannover, Germany.
CORRESPONDENCE ADDRESS
  M. Shrestha, Department of Cardiothoracic, Transplantation and Vascular 
Surgery, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, 
Germany. Email: shrestha.malakh.lal@mh-hannover.de
AiP/IP ENTRY DATE
  2013-10-24
FULL RECORD ENTRY DATE
  2013-10-29
SOURCE
  European Journal of Cardio-thoracic Surgery (2013) 44:5 (949-957) Article 
Number: ezt229. Date of Publication: November 2013
VOLUME
  44
ISSUE
  5
FIRST PAGE
  949
LAST PAGE
  957
DATE OF PUBLICATION
  November 2013
ISSN
  1010-7940
  1873-734X (electronic)
BOOK PUBLISHER
  European Association for Cardio-Thoracis Surgery, 3 Park Street, Windsor, 
Berkshire, United Kingdom.
ABSTRACT
  OBJECTIVES: Since August 2001, the frozen elephant trunk (FET) technique has 
been used at our institution to treat degenerative or dissecting aneurysms 
involving the aortic arch and descending aorta as a potential 'single-stage' 
procedure. The aim of this study was to review our FET experience and to 
present the 10-year results. METHODS: Between August 2001 and January 2012, 
131 patients underwent FET implant with three different prostheses: the 
custommade Chavan-Haverich (n = 66), the Jotec E-vita (n = 30) and the 
Vascutek Thoraflex (n = 35) prostheses. Concomitant procedures included 
aortic valve-sparing operations (David, n = 17) and aortic root replacement 
(Bentall, n = 25). Patient records and the first postoperative and last 
available computer tomography (CT) were retrospectively reviewed. RESULTS: 
Incidence of rethoracotomy for bleeding, stroke, spinal cord injury, 
prolonged ventilatory support (>96 h) and acute renal failure requiring 
dialysis were 18, 11, 1, 41 and 16%, respectively. In-hospital mortality was 
15%. The mean follow-up was 42 ± 37 (range 1-134 months). At 1, 5 and 10 
years, survivals were 82 ± 3, 72 ± 5 and 58 ± 8%, respectively. Freedoms 
from distal aortic operation were 81 ± 4, 67 ± 5 and 43 ± 13%, respectively. 
Thirty-six patients underwent 40 distal aortic operations, either open 
surgical (n = 22, 55%) or endovascular (n = 18, 45%). Chronic aortic 
dissection was identified as an independent risk factor for distal aortic 
operation (odds ratio = 3.8; 95% confidence interval 1.5-9.3; P = 0.004). At 
last CT control, false-lumen thrombosis rates up to 93% were achieved around 
the stent graft. CONCLUSIONS: An FET concept adds to the armament of the 
surgeon in the treatment of complex and diverse aortic arch pathologies. The 
preoperative patient risk profile explains the postoperative morbidity and 
in-hospital mortality. The FET can potentially be still a 'one-stage' 
procedure in selected patients. However, the extension of FET to patients 
with extensive aortic aneurysms has led to an increase in second-stage 
procedures. © The Author 2013. Published by Oxford University Press on 
behalf of the European Association for Cardio-Thoracic Surgery. All rights 
reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic arch surgery; aortic surgery; frozen elephant trunk technique; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication); aged; aortic dissection; aortic prosthesis; aortic root surgery; aortic rupture (complication); article; artificial ventilation; bleeding (complication); cerebrovascular accident (complication); female; follow up; human; intensive care unit; length of stay; major clinical study; male; medical record review; mortality; multiple organ failure (complication); pneumonia (complication); postoperative complication (complication); priority journal; risk factor; spinal cord injury (complication); survival rate; survival time; thoracotomy; tracheotomy; vocal cord paralysis (complication); 
DEVICE TRADE NAMES
  Chavan-Haverich  curative

  Jotec E-vita  Jotec

  Thoraflex  Vascutek

DEVICE MANUFACTURERS
  curative
  Jotec
  Vascutek
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013657761
MEDLINE PMID
  23660556 (http://www.ncbi.nlm.nih.gov/pubmed/23660556)
PUI
  L370047338
DOI
  10.1093/ejcts/ezt229
FULL TEXT LINK
  http://dx.doi.org/10.1093/ejcts/ezt229
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10107940&id=doi:10.1093%2Fejcts%2Fezt229&atitle=Total+aortic+arch+replacement+with+the+frozen+elephant+trunk+technique%3A+10-year+follow-up+single-centre+experience&stitle=Eur.+J.+Cardio-thorac.+Surg.&title=European+Journal+of+Cardio-thoracic+Surgery&volume=44&issue=5&spage=949&epage=957&aulast=Ius&aufirst=Fabio&auinit=F.&aufull=Ius+F.&coden=EJCSE&isbn=&pages=949-957&date=2013&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 480
TITLE
  Respiratory management in the patient with spinal cord injury
AUTHOR NAMES
  Galeiras Vázquez R.; Rascado Sedes P.; Mourelo Fariña M.; Montoto Marqués A.; Ferreiro Velasco M.E.
AUTHOR ADDRESSES
  (Galeiras Vázquez R., ritagaleiras@hotmail.es; Mourelo Fariña M., 
monica.mourelo.farina@sergas.es) Critical Care Unit, Complexo Hospitalario 
Universitario A Coruña, CP. 15006, A Coruña, Spain.
(Rascado Sedes P., pedrorascado@hotmail.com) Critical Care Unit, Complexo 
Hospitalario Universitario de Santiago de Compostela, CP. 15702, Santiago de 
Compostela, Spain.
(Montoto Marqués A., antonio.montoto.marques@sergas.es; Ferreiro Velasco 
M.E., ma.elena.ferreiro.velasco@sergas.es) Spinal Cord Injury Unit, Complexo 
Hospitalario Universitario A Coruña, CP. 15006, A Coruña, Spain.
(Montoto Marqués A., antonio.montoto.marques@sergas.es) Department of 
Medicine, University of A Coruña, CP. 15006, A Coruña, Spain.
CORRESPONDENCE ADDRESS
  R. Galeiras Vázquez, Critical Care Unit, Complexo Hospitalario Universitario 
A Coruña, CP. 15006, A Coruña, Spain. Email: ritagaleiras@hotmail.es
AiP/IP ENTRY DATE
  2013-10-10
FULL RECORD ENTRY DATE
  2013-10-11
SOURCE
  BioMed Research International (2013) 2013 Article Number: 168757. Date of 
Publication: 2013
VOLUME
  2013
DATE OF PUBLICATION
  2013
ISSN
  2314-6133
  2314-6141 (electronic)
BOOK PUBLISHER
  Hindawi Publishing Corporation, 410 Park Avenue, 15th Floor, 287 pmb, New 
York, United States.
ABSTRACT
  Spinal cord injuries (SCIs) often lead to impairment of the respiratory 
system and, consequently, restrictive respiratory changes. Paresis or 
paralysis of the respiratory muscles can lead to respiratory insufficiency, 
which is dependent on the level and completeness of the injury. Respiratory 
complications include hypoventilation, a reduction in surfactant production, 
mucus plugging, atelectasis, and pneumonia. Vital capacity (VC) is an 
indicator of overall pulmonary function; patients with severely impaired VC 
may require assisted ventilation. It is best to proceed with intubation 
under controlled circumstances rather than waiting until the condition 
becomes an emergency. Mechanical ventilation can adversely affect the 
structure and function of the diaphragm. Early tracheostomy following short 
orotracheal intubation is probably beneficial in selected patients. Weaning 
should start as soon as possible, and the best modality is progressive 
ventilator-free breathing (PVFB). Appropriate candidates can sometimes be 
freed from mechanical ventilation by electrical stimulation. Respiratory 
muscle training regimens may improve patients' inspiratory function 
following a SCI. © 2013 Rita Galeiras Vázquez et al.
EMTREE DRUG INDEX TERMS
  beta 2 adrenergic receptor stimulating agent (drug therapy); bronchodilating agent (drug therapy); cholinergic receptor blocking agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; lung complication (drug therapy, complication, drug therapy, surgery, 
therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  abdominal distension (complication); aeration; aerophagia (complication); atelectasis (complication, drug therapy, therapy); barotrauma (complication); breathing exercise; breathing muscle; bronchospasm (drug therapy); cardiac rhythm management device; cervical spinal cord injury; conservative treatment; electrotherapy; endotracheal intubation; extubation; human; hypoventilation (complication, therapy); implanted phrenic nerve stimulator; intermittent positive pressure ventilation; muscle training; noninvasive ventilation; percussion; pneumonia (complication, therapy); positive end expiratory pressure; postoperative complication (complication); postural drainage; quadriplegia; randomized controlled trial (topic); recurrent disease (complication, drug therapy, therapy); rehydration; respiratory distress (complication, therapy); respiratory failure (complication, therapy); respiratory function; review; systematic review (topic); thoracic spinal cord; thorax injury (complication, therapy); tracheostomy; tracheotomy; vena cava filter; ventilator; vibration; weaning; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013617345
MEDLINE PMID
  24089664 (http://www.ncbi.nlm.nih.gov/pubmed/24089664)
PUI
  L369931239
DOI
  10.1155/2013/168757
FULL TEXT LINK
  http://dx.doi.org/10.1155/2013/168757
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=23146133&id=doi:10.1155%2F2013%2F168757&atitle=Respiratory+management+in+the+patient+with+spinal+cord+injury&stitle=BioMed+Res.+Int.&title=BioMed+Research+International&volume=2013&issue=&spage=&epage=&aulast=Galeiras+V%C3%A1zquez&aufirst=Rita&auinit=R.&aufull=Galeiras+V%C3%A1zquez+R.&coden=&isbn=&pages=-&date=2013&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 481
TITLE
  Admission ASIA motor score predicting the need for tracheostomy after 
cervical spinal cord injury
AUTHOR NAMES
  Menaker J.; Kufera J.A.; Glaser J.; Stein D.M.; Scalea T.M.
AUTHOR ADDRESSES
  (Menaker J., jmenaker@umm.edu; Kufera J.A.; Glaser J.; Stein D.M.; Scalea 
T.M.) Departments of Surgery, and Emergency Medicine Secondary, University 
of Maryland School of Medicine, R Adams Cowley ShockTrauma Center, 22 
SouthGreene St., T1R60, Baltimore, MD 21201, United States.
CORRESPONDENCE ADDRESS
  J. Menaker, Departments of Surgery, and Emergency Medicine Secondary, 
University of Maryland School of Medicine, R Adams Cowley ShockTrauma 
Center, 22 SouthGreene St., T1R60, Baltimore, MD 21201, United States. 
Email: jmenaker@umm.edu
AiP/IP ENTRY DATE
  2013-10-18
FULL RECORD ENTRY DATE
  2013-10-22
SOURCE
  Journal of Trauma and Acute Care Surgery (2013) 75:4 (629-634). Date of 
Publication: October 2013
VOLUME
  75
ISSUE
  4
FIRST PAGE
  629
LAST PAGE
  634
DATE OF PUBLICATION
  October 2013
ISSN
  2163-0755
  2163-0763 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  BACKGROUND: Respiratory compromise and the need for tracheostomy are common 
after cervical spinal cord injury (cSCI). The purpose of the study was to 
evaluate if admission American Spinal Injury Association (ASIA) motor score 
is associated with the need for tracheostomy following cSCI. METHODS: The 
trauma registry identified patients with isolated cSCI during a 3-year 
period. Patients with an Abbreviated Injury Scale score greater than 3 in 
other body regions were excluded. Medical records were reviewed for 
demographics, admission ASIA motor score, ASIA Impairment Scale (AIS), 
anatomic level of injury, need for a tracheostomy, and length of stay (LOS). 
Logistic regression models were constructed to examine the effect of 
admission ASIA motor scores on the outcome of tracheostomy. Cox proportional 
hazards models were fit to determine risk factors for time to tracheostomy. 
RESULTS: A total of 128 patients were identified. Seventy-four patients had 
a tracheostomy performed on mean (SD) hospital Day 9 (4). Median admission 
ASIA motor score was 22.0 (interquartile range [IQR], 8-54). Median anatomic 
level of injury was 5 (IQR, 4-6). Patients requiring tracheostomy had 
significantly lower median admission ASIA motor score (9 [IQR, 3-17] vs. 57 
[IQR, 30-77], p < 0.001) and were more likely to be an AIS A. There was no 
difference in median anatomic level of injury (5 [IQR, 4-5.8] vs. 5 [IQR, 
4-6], p = nonsignificant). ASIA motor scores less than 10 had an unadjusted 
odds ratio for requiring tracheostomy of 56 (95 confidence interval, 7-426). 
Following adjustment for independent risk factors, the odds ratio for ASIA 
motor score less than 10 remained statistically significant at 22 
(confidence interval, 3-180). Among patients with incomplete cSCI, ASIA 
motor scores increased significantly from AIS B to AIS D, while Injury 
Severity Score (ISS), LOS and intensive care unit LOS declined 
significantly. Of those patients without a tracheostomy, 100% had an ASIA 
motor score greater than 10, 98% had an ASIA motor score greater than 20, 
and 86% had an ASIA motor score greater than 25. Among patients with an ASIA 
motor score less than 10, 100% had a tracheostomy; among patients with an 
ASIA motor score less than 20, 96% had a tracheostomy. Among patients with a 
tracheostomy, 91% were an AIS B or C, while 85% of patients classified as 
AIS D did not have a tracheostomy. CONCLUSION: Tracheostomy after cSCI is 
common. Lower admission ASIA motor score and complete cSCI are significantly 
associated with the need for tracheostomy. Anatomic level of injury was not 
associated with tracheostomy after cSCI. Classification of incomplete 
patients by AIS indicates that ASIA motor score may be used as a surrogate 
for grade of injury. When looking only at patients with an incomplete cSCI, 
those with an admission ASIA score of less than 10 should have an early 
tracheostomy. Those with an AIS D scale should not be considered for early 
tracheostomy. © 2013 Lippincott Williams and Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American Spinal Injury Association impairment scale; cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; controlled study; female; hospital admission; human; injury scale; injury severity; intensive care unit; length of stay; major clinical study; male; medical record review; prediction; priority journal; register; risk factor; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013640378
MEDLINE PMID
  24064876 (http://www.ncbi.nlm.nih.gov/pubmed/24064876)
PUI
  L369994077
DOI
  10.1097/TA.0b013e3182a12b86
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e3182a12b86
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630755&id=doi:10.1097%2FTA.0b013e3182a12b86&atitle=Admission+ASIA+motor+score+predicting+the+need+for+tracheostomy+after+cervical+spinal+cord+injury&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=75&issue=4&spage=629&epage=634&aulast=Menaker&aufirst=Jay&auinit=J.&aufull=Menaker+J.&coden=&isbn=&pages=629-634&date=2013&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 482
TITLE
  Spinal cord avulsion in the pediatric population: Case study and review
AUTHOR NAMES
  Phillips B.C.; Pinckard H.; Pownall A.; Öcal E.
AUTHOR ADDRESSES
  (Phillips B.C., phillipsblakec@uams.edu; Pinckard H.; Pownall A.; Öcal E.) 
Department of Neurosurgery, University of Arkansas for Medical Sciences, 
4301 W. Markham Slot #507, Little Rock, AR 72205, United States.
CORRESPONDENCE ADDRESS
  B.C. Phillips, Department of Neurosurgery, University of Arkansas for 
Medical Sciences, 4301 W. Markham Slot #507, Little Rock, AR 72205, United 
States. Email: phillipsblakec@uams.edu
AiP/IP ENTRY DATE
  2013-10-17
FULL RECORD ENTRY DATE
  2013-10-21
SOURCE
  Pediatric Emergency Care (2013) 29:10 (1111-1113). Date of Publication: 
October 2013
VOLUME
  29
ISSUE
  10
FIRST PAGE
  1111
LAST PAGE
  1113
DATE OF PUBLICATION
  October 2013
ISSN
  0749-5161
  1535-1815 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Spinal cord injury without radiographic abnormality (SCIWORA) is a rare 
phenomenon, but with advances in imaging and improvements in magnetic 
resonance imaging more cases are being identified. Even more uncommon is the 
finding of spinal cord avulsion as a type of SCIWORA with only single case 
reports in the literature. We present the case reports of 2 patients both 
experiencing spinal cord avulsion as a type of SCIWORA, secondary to 
improper lap-belt restraint during a motor vehicle accident. Copyright © 
2013 by Lippincott Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  dopamine; noradrenalin; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood injury; spinal cord avulsion; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  article; bradycardia; case report; child; computer assisted tomography; contusion; emergency care; feeding apparatus; human; hypotension; male; nuclear magnetic resonance imaging; occupational therapy; physiotherapy; preschool child; school child; speech therapy; tracheostomy; traffic accident; 
CAS REGISTRY NUMBERS
  dopamine (51-61-6, 62-31-7)
  noradrenalin (1407-84-7, 51-41-2)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013638549
MEDLINE PMID
  24084611 (http://www.ncbi.nlm.nih.gov/pubmed/24084611)
PUI
  L369987945
DOI
  10.1097/PEC.0b013e3182a62fab
FULL TEXT LINK
  http://dx.doi.org/10.1097/PEC.0b013e3182a62fab
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07495161&id=doi:10.1097%2FPEC.0b013e3182a62fab&atitle=Spinal+cord+avulsion+in+the+pediatric+population%3A+Case+study+and+review&stitle=Pediatr.+Emerg.+Care&title=Pediatric+Emergency+Care&volume=29&issue=10&spage=1111&epage=1113&aulast=Phillips&aufirst=Blake+C.&auinit=B.C.&aufull=Phillips+B.C.&coden=PECAE&isbn=&pages=1111-1113&date=2013&auinit1=B&auinitm=C
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 483
TITLE
  Evaluation at five years of post-acute unit (UPR) at the Saint-Hélier Pole, 
Rennes
AUTHOR NAMES
  Autret K.; Durufle-Tapin A.; Robineau S.; Nicolas B.; Gallien P.; Petrilli S.; Le Meur C.
AUTHOR ADDRESSES
  (Autret K., katell.autret@pole-sthelier.com; Durufle-Tapin A.; Robineau S.; 
Nicolas B.; Gallien P.; Petrilli S.; Le Meur C.) Pôle Saint-Hélier, 54, rue 
Saint-Hélier, Rennes, France.
CORRESPONDENCE ADDRESS
  K. Autret, Pôle Saint-Hélier, 54, rue Saint-Hélier, Rennes, France. Email: 
katell.autret@pole-sthelier.com
FULL RECORD ENTRY DATE
  2013-11-20
SOURCE
  Annals of Physical and Rehabilitation Medicine (2013) 56 SUPPL. 1 (e276). 
Date of Publication: October 2013
VOLUME
  56
FIRST PAGE
  e276
DATE OF PUBLICATION
  October 2013
CONFERENCE NAME
  28e Congres de Medecine Physique et de Readaptation
CONFERENCE LOCATION
  Reims, France
CONFERENCE DATE
  2013-10-17 to 2013-10-19
ISSN
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS
ABSTRACT
  Introduction.- Post-intensive care rehabilitation services aren't currently 
normalized by any text. The 2012 brain injuries and spinal cord injuries 
action program plans a study of this type of structure. Method.- Four UPR 
beds were created in 2008 at the Pôle Saint-Hélier in Rennes. In 2010, four 
extra beds were opened.We suggest a five years existence assessment of this 
unit, from January 2008 to December 2012. Epidemiological data (age, sex), 
medical (pathology type, occurrence of a tracheotomy, enteral feeding) and 
administrative (average duration of hospital stay, hospital service of 
origin and leaving mode) were collected. Results.- Eighty-one patients were 
admitted in UPR in five years. The UPR admission delay is four weeks. The 
median age of the patients is 50.72 years. Pathologies are primarily 
cerebral lesions (stroke, brain injury, anoxia...), then spinal cord 
injuries or rehabilitation after multi-visceral failure. Seventy-five 
patients had a tracheotomy at the time of their admission. Sixty-nine had a 
gastrostomy. The average duration of stay in UPR is 11.8 weeks. At five 
years, 62 of the 81 patients had left the hospital, including 43 who could 
go back to home. Conclusion.- The activity of a UPR, between acute care 
services and rehabilitation, meets a need for public health. This type of 
unit allows patients to access early rehabilitation care in a medically 
monitored environment. The issue of downstream chain remains the main 
obstacle to a steady output flow and to the decrease of stay duration in 
upstream services.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adaptation; Christian; epidemiology; 
EMTREE MEDICAL INDEX TERMS
  anoxia; brain damage; brain injury; cerebrovascular accident; emergency care; enteric feeding; environment; epidemiological data; gastrostomy; hospital; hospital service; hospitalization; human; intensive care; pathology; patient; public health; rehabilitation; rehabilitation care; rehabilitation center; spinal cord injury; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71225155
DOI
  10.1016/j.rehab.2013.07.1082
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2013.07.1082
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770657&id=doi:10.1016%2Fj.rehab.2013.07.1082&atitle=Evaluation+at+five+years+of+post-acute+unit+%28UPR%29+at+the+Saint-H%C3%A9lier+Pole%2C+Rennes&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=56&issue=&spage=e276&epage=&aulast=Autret&aufirst=K.&auinit=K.&aufull=Autret+K.&coden=&isbn=&pages=e276-&date=2013&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 484
TITLE
  Successful weaning after cervical spinal cord injury. Preliminary reslts in 
34 tetraplegic patients
AUTHOR NAMES
  Hamsen U.; Ramczykowski T.; Kuhs O.; Aach M.; Schildhauer T.A.; Swol J.
AUTHOR ADDRESSES
  (Hamsen U.; Ramczykowski T.; Kuhs O.; Aach M.; Schildhauer T.A.; Swol J.) BG 
University Hospital Bergmannsheil, Department of General and Trauma Surgery, 
Bochum, Germany.
CORRESPONDENCE ADDRESS
  U. Hamsen, BG University Hospital Bergmannsheil, Department of General and 
Trauma Surgery, Bochum, Germany.
FULL RECORD ENTRY DATE
  2014-05-12
SOURCE
  Intensive Care Medicine (2013) 39 SUPPL. 2 (S258). Date of Publication: 
October 2013
VOLUME
  39
FIRST PAGE
  S258
DATE OF PUBLICATION
  October 2013
CONFERENCE NAME
  26th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2013
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2013-10-05 to 2013-10-09
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction. Cervical spinal cord injury with tetraplegia lead to 
respiratory failure and long-term invasive ventilation. Due to the spinal 
shock the mucosal clearance is reduced. There is a high risk of 
ventilator-associated pneumonia. The swallow disability is often present. 
The paralysis of the intercostal musculature leads to dependence of 
respirator. METHODS. All patients suffered from acute spinal cord injury 
with tetraplegia. Injury, clinical course and outcome data was extracted 
retrospectively using the ICU database. To evaluate predictors for 
successful weaning we assessed 34 consecutive patients (31 male, 3 female; 
age 60.7 ±: 17.3 years) treated in our center between 1.10.2010 and 
1.12.2011. RESULTS. 32 of 34 patients were discharged from hospital, 2 
patients died within hospital stay. 33 patients received tracheostoma for 
weaning. Mean days ventilated before performed tracheostomy was 9.6 ±: 8.7. 
28 patients left hospital weaned from ventilator (88 %). 13 of 28 patients 
left hospital without tracheostoma. Mean duration of ventilation was 30.1 ±: 
24.7 days. CONCLUSIONS. Tetraplegic patients are often at an advanced age 
([50 years old), which is an unfavorable situation for weaning. Percutaneous 
tracheostomy simplifies phoniation because the stoma is better sealed. 
Percutaneous gastrostomy prevents microaspiration and recurrent pneumonia. 
Weaning from mechanical ventilation is possible and should be aimed once the 
patient has adapted to the new situation of tetraplegia after resolution of 
spinal shock.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; human; intensive care; patient; society; weaning; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; artificial ventilation; data base; disability; disease course; female; gastrostomy; hospital; hospitalization; injury; male; muscle; paralysis; pneumonia; quadriplegia; respiratory failure; risk; spinal cord injury; stoma; swallow (bird); trachea stoma; tracheostomy; ventilator; ventilator associated pneumonia; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71446114
DOI
  10.1007/s00134-013-3095-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-013-3095-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-013-3095-5&atitle=Successful+weaning+after+cervical+spinal+cord+injury.+Preliminary+reslts+in+34+tetraplegic+patients&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=39&issue=&spage=S258&epage=&aulast=Hamsen&aufirst=U.&auinit=U.&aufull=Hamsen+U.&coden=&isbn=&pages=S258-&date=2013&auinit1=U&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 485
TITLE
  An autopsied case of progressive supranuclear palsy presenting with 
cerebellar ataxia and severe cerebellar involvement
AUTHOR NAMES
  Iwasaki Y.; Mori K.; Ito M.; Tatsumi S.; Mimuro M.; Yoshida M.
AUTHOR ADDRESSES
  (Iwasaki Y., iwasaki@sc4.so-net.ne.jp; Tatsumi S.; Mimuro M.; Yoshida M.) 
Department of Neuropathology, Institute for Medical Science of Aging, Aichi 
Medical University, Nagakute, Japan.
(Mori K.; Ito M.) Department of Neurology, Oyamada Memorial Spa Hospital, 
Yokkaichi, Japan.
CORRESPONDENCE ADDRESS
  Y. Iwasaki, Department of Neuropathology, Institute for Medical Science of 
Aging, Aichi Medical University, 1-1 Yazakokarimata, Nagakute 480-1195, 
Japan. Email: iwasaki@sc4.so-net.ne.jp
AiP/IP ENTRY DATE
  2013-01-22
FULL RECORD ENTRY DATE
  2013-10-15
SOURCE
  Neuropathology (2013) 33:5 (561-567). Date of Publication: October 2013
VOLUME
  33
ISSUE
  5
FIRST PAGE
  561
LAST PAGE
  567
DATE OF PUBLICATION
  October 2013
ISSN
  0919-6544
  1440-1789 (electronic)
BOOK PUBLISHER
  Blackwell Publishing, 550 Swanston Street, Carlton South, Australia.
ABSTRACT
  A Japanese male patient presented with gait disturbance at the age of 69 
years. His principal symptom was cerebellar ataxia for several years. He was 
initially diagnosed as having olivopontocerebellar atrophy because 
dysarthria and ataxia gradually developed, and head CT scan showed apparent 
atrophy of the cerebellum and brainstem and dilatation of the fourth 
ventricle. Later, he showed vertical gaze palsy, dysphagia, retrocollis, 
parkinsonism, axial dominant rigidity and grasp reflex, and therefore, the 
diagnosis was modified to progressive supranuclear palsy (PSP). Progressive 
atrophy of the frontotemporal lobe, cerebellum and brainstem, and dilatation 
of the lateral, third and fourth ventricles were evident on MRI. Gastrostomy 
and tracheotomy were performed 9 and 10 years after onset, respectively, and 
the patient died after 11 years disease duration. At autopsy the brain 
weighed 1000g and showed atrophy of the frontotemporal lobe, cerebellum and 
brainstem. Neurofibrillary tangles, mainly globose-type revealed by 
Gallyas-Braak silver staining, were extensively observed in the cerebral 
cortex and subcortical grey matter. Numerous glial fibrillary tangles, 
including tuft-shaped astrocytes and coiled bodies, and extensive 
argyrophilic threads were also recognized, particularly in the frontal lobe, 
basal ganglia, cerebellar white matter, brainstem and spinal cord. The 
Purkinje cell layer showed severe neuron loss with Bergmann's gliosis, and 
the dentate nucleus showed severe neuron loss with grumose degeneration. 
Tau-positive/Gallyas-positive inclusions in the Purkinje cells and the glial 
cells of the Purkinje cell layer were observed. Pathological findings of the 
present patient were consistent with the diagnosis of PSP, but the 
olivopontocerebellar involvement, particularly in the cerebellum, was 
generally more severe, and the quantity of tau-positive/Gallyas-positive 
structures were more abundant than in typical PSP cases. The existence of a 
distinct, rare PSP subtype with severe olivopontocerebellar involvement, 
"PSP-C", which tends to be clinically misdiagnosed as spinocerebellar 
degeneration in the early disease stage, is noteworthy. The present case 
corresponded to this rare subtype of PSP. © 2013 Japanese Society of 
Neuropathology.
EMTREE DRUG INDEX TERMS
  tau protein (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autopsy; cerebellar ataxia; cerebellum disease; progressive supranuclear palsy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  aged; article; astrocyte; ataxia; brain atrophy; brain cortex; brain fourth ventricle; brain stem; brain ventricle dilatation; brain weight; case report; cause of death; cerebellum atrophy; cervical dystonia; coiled body; computer assisted tomography; dentate nucleus; depigmentation; diagnostic error; disease duration; dysarthria; dysphagia; frontal lobe; gastrostomy; gaze paralysis; glia cell; gliosis; globus pallidus; gray matter; human; human tissue; immunohistochemistry; Japanese (people); male; mortality; muscle rigidity; neurofibrillary tangle; neuroimaging; neuropathology; nuclear magnetic resonance imaging; olivopontocerebellar atrophy; parkinsonism; priority journal; Purkinje cell; reflex; silver staining; spinal cord; spinocerebellar degeneration (diagnosis); subcortex; substantia nigra; subthalamic nucleus; temporal lobe; tracheotomy; white matter; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013622380
MEDLINE PMID
  23320789 (http://www.ncbi.nlm.nih.gov/pubmed/23320789)
PUI
  L52400708
DOI
  10.1111/neup.12012
FULL TEXT LINK
  http://dx.doi.org/10.1111/neup.12012
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:10.1111%2Fneup.12012&atitle=An+autopsied+case+of+progressive+supranuclear+palsy+presenting+with+cerebellar+ataxia+and+severe+cerebellar+involvement&stitle=Neuropathology&title=Neuropathology&volume=33&issue=5&spage=561&epage=567&aulast=Iwasaki&aufirst=Yasushi&auinit=Y.&aufull=Iwasaki+Y.&coden=NOPAF&isbn=&pages=561-567&date=2013&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 486
TITLE
  A cursed case of respiratory failure
AUTHOR NAMES
  Sajjad H.; Nostrand K.V.; Graham Carlos W.
AUTHOR ADDRESSES
  (Sajjad H.; Nostrand K.V.; Graham Carlos W.) Indiana University, 
Indianapolis, United States.
CORRESPONDENCE ADDRESS
  H. Sajjad, Indiana University, Indianapolis, United States.
FULL RECORD ENTRY DATE
  2013-12-27
SOURCE
  Chest (2013) 144:4 MEETING ABSTRACT. Date of Publication: October 2013
VOLUME
  144
ISSUE
  4
DATE OF PUBLICATION
  October 2013
CONFERENCE NAME
  CHEST 2013
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2013-10-26 to 2013-10-31
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians
ABSTRACT
  INTRODUCTION: Ondine's curse is a condition which involves autonomic 
respiratory failure during sleep that is fatal if untreated. This disorder 
can be inherited and present during infancy as congenital central 
hypoventilation or it can present during adulthood when it is called primary 
alveolar hypoventilation. Uncommonly it presents as a brain or high cervical 
spinal cord injury. Worldwide approximately 200 cases have been reported 
with very few presenting as adults. We present a case of this rare disease 
following pontomedullary hemorrhage in an adult woman. CASE PRESENTATION: A 
77 year-old African American woman with history of hypertension and 
peripheral vascular disease was hospitalized for dizziness secondary to 
carbon monoxide exposure. On hospital day four she developed new onset 
slurred speech, right sided facial droop and confusion requiring intubation 
and mechanical ventilation. Head computer tomography (CT) showed hemorrhage 
involving the right posterior medulla. She could not be liberated from the 
ventilator due to frequent, prolonged apneas while asleep consistent with 
Ondine's curse. These episodes continued despite minimizing sedating 
medications and trialing various modes of mechanical ventilation. In an 
effort to increase alveolar ventilation acetazolamide was started. It 
appeared to be effective as evidenced by decreased apneic spells. Despite 
less frequent apneas the patient ultimately required a tracheostomy and 
remains on mechanical ventilation when sleeping. DISCUSSION: Hypoventilation 
syndromes are common following cerebrovascular accidents. However, 
hypoventilation that occurs exclusively during sleep, the dreaded «curse» of 
Ondine, is quite rare. This case reviews treatment considerations including 
acetazolamide and early tracheostomy. The tracheostomy simplifies 
ventilation while asleep whereas the acetazolamide increases ventilatory 
drive. While our patient remained «cursed» during her inpatient stay, the 
literature suggests that she may improve over the coming months, regaining 
her autonomic drive. CONCLUSIONS: Ondine's Curse is a rare syndrome that 
affects autonomic ventilatory drive during sleep. This case reviews 
treatment considerations including acetazolamide and early tracheostomy that 
may improve overall outcomes.
EMTREE DRUG INDEX TERMS
  acetazolamide; carbon monoxide; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure; 
EMTREE MEDICAL INDEX TERMS
  adult; adulthood; African American; air conditioning; apnea; artificial ventilation; bleeding; brain; cerebrovascular accident; cervical spinal cord injury; computer assisted tomography; diseases; dizziness; drug therapy; exposure; female; hospital; hospital patient; human; hypertension; hypoventilation; infancy; intubation; lung alveolus hypoventilation; lung ventilation; patient; peripheral vascular disease; rare disease; sleep; slurred speech; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71269139
DOI
  10.1378/chest.1675147
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.1675147
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.1675147&atitle=A+cursed+case+of+respiratory+failure&stitle=Chest&title=Chest&volume=144&issue=4&spage=&epage=&aulast=Sajjad&aufirst=Hassan&auinit=H.&aufull=Sajjad+H.&coden=&isbn=&pages=-&date=2013&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 487
TITLE
  Ventilator-associated pneumonia in trauma patients with open tracheotomy: 
Predictive factors and prognosis impact
AUTHOR NAMES
  Chaari A.; Kssibi H.; Zribi W.; Medhioub F.; Chelly H.; Algia N.B.; Hamida C.B.; Bahloul M.; Bouaziz M.
AUTHOR ADDRESSES
  (Chaari A., anischaari2004@yahoo.fr; Kssibi H.; Medhioub F.; Chelly H.; 
Algia N.B.; Hamida C.B.; Bahloul M.; Bouaziz M.) Department of Intensive 
Care, Habib Bourguiba University Hospital, Sfax, Tunisia.
(Zribi W.) Department of Orthopedic Surgery, Habib Bourguiba University 
Hospital, Sfax, Tunisia.
CORRESPONDENCE ADDRESS
  A. Chaari, Department of Intensive Care, Habib Bourguiba University 
Hospital, Sfax, Tunisia. Email: anischaari2004@yahoo.fr
AiP/IP ENTRY DATE
  2013-12-16
FULL RECORD ENTRY DATE
  2013-12-21
SOURCE
  Journal of Emergencies, Trauma and Shock (2013) 6:4 (246-251). Date of 
Publication: October-December 2013
VOLUME
  6
ISSUE
  4
FIRST PAGE
  246
LAST PAGE
  251
DATE OF PUBLICATION
  October-December 2013
ISSN
  0974-2700
  0974-519X (electronic)
BOOK PUBLISHER
  Medknow Publications and Media Pvt. Ltd, B9, Kanara Business Centre, off 
Link Road, Ghatkopar (E), Mumbai, India.
ABSTRACT
  Objective: To assess the predictive factors of ventilator associated 
pneumonia (VAP) occurrence following open tracheotomy in trauma patients. 
Materials and Methods: We conducted an observational, prospective study over 
15 months, between 01/08/2010 and 30/11/2011. All trauma patients (except 
those with cervical spine trauma), older than 15 years, undergoing open 
tracheotomy during their ICU stay were included. All episode of VAP 
following tracheotomy were recorded. Predictive factor of VAP onset were 
studied. Results: We included 106 patients. Mean age was 37.9 ± 15.5 years. 
Mean Glasgow coma Scale (GCS) was 8.5 ± 3.7 and mean Injury Severity Score 
(ISS) was 53.1 ± 23.8. Tracheotomy was performed for 53 patients (50%) 
because of prolonged ventilation whereas 83 patients (78.3%) had tracheotomy 
because of projected long mechanical ventilation. Tracheotomy was performed 
within 8.6 ± 5.3 days. Immediate complications were bleeding events (22.6%) 
and barotrauma (0.9%). Late complications were stomal infection (28.3%) and 
VAP (52.8%). In multivariate analysis, independent factors predicting VAP 
onset were delayed tracheotomy (OR = 0.041; CI95% [1.02-7.87]; P = 0.041) 
and stomal infection (OR = 3.04; CI95% [1.02-9.93]; P = 0.045).Thirty three 
patients died in ICU (31.1%) without significant impact of VAP on mortality. 
Conclusion: Late tracheotomy and stomal infection are independent factors 
predicting VAP onset after open tracheotomy in trauma patients. The 
occurrence of VAP prolongers mechanical ventilation duration and intensive 
care unit (ICU) length of stay (LOS) but doesn't increase mortality.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal injury; head injury; pelvis injury; thorax injury; tracheotomy; ventilator associated pneumonia; 
EMTREE MEDICAL INDEX TERMS
  adult; anisocoria; article; artificial ventilation; barotrauma (complication); catheter infection (complication); clinical trial; female; follow up; Glasgow coma scale; hospitalization; human; injury scale; intensive care unit; major clinical study; male; observational study; postoperative complication (complication); postoperative hemorrhage (complication); postoperative infection (complication); predictive value; priority journal; prognosis; prospective study; stomal infection (complication); tonic clonic seizure; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013775098
PUI
  L370421685
DOI
  10.4103/0974-2700.120364
FULL TEXT LINK
  http://dx.doi.org/10.4103/0974-2700.120364
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09742700&id=doi:10.4103%2F0974-2700.120364&atitle=Ventilator-associated+pneumonia+in+trauma+patients+with+open+tracheotomy%3A+Predictive+factors+and+prognosis+impact&stitle=J.+Emerg.+Trauma+Shock&title=Journal+of+Emergencies%2C+Trauma+and+Shock&volume=6&issue=4&spage=246&epage=251&aulast=Chaari&aufirst=Anis&auinit=A.&aufull=Chaari+A.&coden=&isbn=&pages=246-251&date=2013&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 488
TITLE
  Prolonged bradycardia and asystole in high spinal cord injury patients: Risk 
factors and management
AUTHOR NAMES
  Shaikh N.; Raza A.; Hanssens Y.; Malmstrom M.F.
AUTHOR ADDRESSES
  (Shaikh N.; Malmstrom M.F.) Hamad General Hospital, Anesthesia and Intensive 
Care, Doha, Qatar.
(Raza A.) Hamad General Hospital, Neurosurgery, Doha, Qatar.
(Hanssens Y.) Hamad General Hospital, Clinical Pharmacy Services, Doha, 
Qatar.
CORRESPONDENCE ADDRESS
  N. Shaikh, Hamad General Hospital, Anesthesia and Intensive Care, Doha, 
Qatar.
FULL RECORD ENTRY DATE
  2014-05-12
SOURCE
  Intensive Care Medicine (2013) 39 SUPPL. 2 (S293). Date of Publication: 
October 2013
VOLUME
  39
FIRST PAGE
  S293
DATE OF PUBLICATION
  October 2013
CONFERENCE NAME
  26th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2013
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2013-10-05 to 2013-10-09
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction. High spinal cord injury (HSCI) is one of the devastating 
traumatic injuries. Eighty percent of these patients are young male, and 93 
% of them will have major neurological disabilities having great financial 
impact on patient0s family as well as the health care system. There is 
paucity of literature about prolonged bradycardia in HSCI patients. 
OBJECTIVES. To evalaute the prevalence, duration, risk factors, 
precipitating factors for prolonged bradycardia, and its association with 
pneumonia, positioning or endotracheal suction in the HSCI patients. 
METHODS. All patients who were admitted to the intensive care unit (ICU) of 
Hamad General Hospital, a tertiary hospital, with spinal cord injury above 
level of dorsal (D4) were enrolled in this study. Data collected include: 
patient's demographic data, mechanism, level and type of spinal injury, 
associated injuries, injury severity score (ISS), spinal shock vasopressors 
used, time of occurrence of bradycardia, treatment of bradycardia, chest 
X-ray finding at the occurrence of bradycardia, relation of bradycardia with 
endotracheal suctioning or position of the patient, ICU stay, tracheostomy, 
any other complications and outcome. RESULTS. During the study period (from 
January 2004 through December 2009), 138 patients were admitted to the ICU 
with HSCI. The majority of patients were male (96 %). The most frequently 
associated injury in these patients was skeletal fractures (38.4 %) and most 
common complication was pneumonia 56 (41 %). Forty five patients (33 %) had 
prolonged bradycardia; 87 % of these patients had pneumonia when bradycardia 
occurred 53.4 % of them had asystole, 77.8 % required tracheostomy. 40 (29 
%) of total HSCI patients had spinal shock at admission, 29 (21 %) patients 
of them had bradycardia at the time of endotracheal suctioning whereas 27 
(20 %) patients developed bradycardia at the time of position. Majority of 
the patients were managed conservatively. Those HSCI patients who developed 
prolonged bradycardia, their ISS score was statistically higher compared to 
the HSCI patients without prolonged bradycardia (43.5 ±: 14 vs 34.4 ±: 16.6 
p = 0.02). ICU stay (38.8 ±: 29 vs 9.6 ±: 11.9, p = 0.001) and hospital stay 
(63 ±: 55 vs 27 ±: 34, p = 0.002) were also found significantly higher 
compared with those HSCI patient without prolonged bradycardia. Multivariate 
analysis showed that hypotension on admission (OR = 10.66, 95 % C.I. 
2.8-40.6, p = 0.001), pneumonia (OR = 3.5, 95 % CI 0.9-14.0, P = 0.05) and 
tracheostomy (OR = 6.3, 95 % C.I. 1.67-23.5, p = 0.006) were the risk 
factors for the development of prolonged bradycardia in HSCI patients. 
CONCLUSIONS. Prolonged bradycardia was significantly associated with higher 
incidence of asystole. Endotracheal suctioning and positioning of HSCI 
patients were significant provocative factors for prolonged bradycardia 
whereas, hypotension on admission, pneumonia and tracheostomy played major 
role for the development of prolonged bradycardia in these patients.
EMTREE DRUG INDEX TERMS
  hypertensive factor; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bradycardia; heart arrest; human; intensive care; patient; risk factor; society; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  disability; epidemiology; fracture; general hospital; health care system; hospitalization; hypotension; injury; injury scale; intensive care unit; male; multivariate analysis; pneumonia; prevalence; spine injury; tertiary care center; thorax radiography; tracheobronchial toilet; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71446229
DOI
  10.1007/s00134-013-3095-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-013-3095-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-013-3095-5&atitle=Prolonged+bradycardia+and+asystole+in+high+spinal+cord+injury+patients%3A+Risk+factors+and+management&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=39&issue=&spage=S293&epage=&aulast=Shaikh&aufirst=N.&auinit=N.&aufull=Shaikh+N.&coden=&isbn=&pages=S293-&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 489
TITLE
  Rapidly progressive severe tracheal stenosis in a C2 spinal cord injured 
patient following elective spine surgery: A case report
AUTHOR NAMES
  Sizer C.; Castillo C.; Sizer C.
AUTHOR ADDRESSES
  (Castillo C.; Sizer C.)
(Sizer C.) MedStar National Rehabilitation Network, Washington, United 
States.
CORRESPONDENCE ADDRESS
  C. Sizer, MedStar National Rehabilitation Network, Washington, United 
States.
FULL RECORD ENTRY DATE
  2013-11-01
SOURCE
  PM and R (2013) 5:9 SUPPL. 1 (S257-S258). Date of Publication: September 
2013
VOLUME
  5
ISSUE
  9
FIRST PAGE
  S257
LAST PAGE
  S258
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  2013 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  National Harbor, MD, United States
CONFERENCE DATE
  2013-10-03 to 2013-10-06
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: We report a rare case of rapidly progressive severe 
tracheal stenosis in a C2 motor incomplete SCI patient following elective 
anterior cervical decompression with posterior fusion. The patient presented 
with insidious onset of dyspnea on exertion, weakened speaking voice, and 
noisy breathing during his rehabilitation process. Bronchoscopy showed a 
combination of Grade III tracheal stenosis (60% narrowing) and 
tracheomalacia. Through the multidisciplinary team, including ENT, 
pulmonology, cardiothoracic surgery and SCI medicine, management was 
established. Progressive worsening of dyspnea with apneic episodes noticed 
days before his scheduled tracheal dilatation. Subsequent bronchoscopy 
showed critical tracheal stenosis (>90%), requiring emergent tracheotomy in 
the operating room. Setting: Acute inpatient rehabilitation hospital. 
Results or Clinical Course: The patient returned to the SCI rehabilitation 
unit to complete his rehabilitation program, eventually returning home with 
tracheostomy and possible tracheal dilations as an outpatient. Discussion: 
The rapidly progressive nature of tracheal stenosis in this SCI patient 
raises many questions and serious concerns for the rehabilitation physician. 
There is limited data on tracheal stenosis in the SCI population other than 
a single observational study published in 1987. Often, symptoms of tracheal 
stenosis present in the rehabilitation setting, placing the responsibility 
of recognizing and diagnosing this serious complication on the 
rehabilitation physician. Conclusions: Tracheal stenosis after elective 
spine surgery is a rare, but potentially life-threatening, complication. It 
is important for rehabilitation professionals to have a high index of 
suspicion and awareness of this serious complication to ensure early 
detection and management.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; human; patient; physical medicine; rehabilitation; spinal cord; spine surgery; trachea stenosis; 
EMTREE MEDICAL INDEX TERMS
  breathing; bronchoscopy; decompression; dilatation; disease course; dyspnea; exercise; hospital; hospital patient; observational study; operating room; otorhinolaryngology; outpatient; physician; population; pulmonology; responsibility; speech; thorax surgery; tracheomalacia; tracheostomy; tracheotomy; voice; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71206027
DOI
  10.1016/j.pmrj.2013.08.431
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pmrj.2013.08.431
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:10.1016%2Fj.pmrj.2013.08.431&atitle=Rapidly+progressive+severe+tracheal+stenosis+in+a+C2+spinal+cord+injured+patient+following+elective+spine+surgery%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=5&issue=9&spage=S257&epage=S258&aulast=Castillo&aufirst=Camilo&auinit=C.&aufull=Castillo+C.&coden=&isbn=&pages=S257-S258&date=2013&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 490
TITLE
  The effectiveness of early tracheostomy (within at least 10 days) in 
cervical spinal cord injury patients
AUTHOR NAMES
  Choi H.J.; Paeng S.H.; Kim S.T.; Lee K.S.; Kim M.S.; Jung Y.T.
AUTHOR ADDRESSES
  (Choi H.J.; Paeng S.H., shpaeng@empas.com; Kim S.T.; Lee K.S.; Kim M.S.; 
Jung Y.T.) Department of Neurosurgery, School of Medicine, Inje University, 
Busan Paik Hospital, Busan, South Korea.
CORRESPONDENCE ADDRESS
  S. H. Paeng, Department of Neurosurgy, College of Medicine, Inje University, 
Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, Busan 614-735, South Korea. 
Email: shpaeng@empas.com
AiP/IP ENTRY DATE
  2013-11-21
FULL RECORD ENTRY DATE
  2013-12-10
SOURCE
  Journal of Korean Neurosurgical Society (2013) 54:3 (220-224). Date of 
Publication: September 2013
VOLUME
  54
ISSUE
  3
FIRST PAGE
  220
LAST PAGE
  224
DATE OF PUBLICATION
  September 2013
ISSN
  2005-3711
  1598-7876 (electronic)
BOOK PUBLISHER
  Korean Neurosurgical Society, #407, Dong-A Villate 2nd Town, 1678-2 
Seocho-dong, Seocho-gu, Seoul, South Korea.
ABSTRACT
  Objective: This study aimed to determine the optimal time for tracheostomy 
by evaluating the benefits and safety of early versus late tracheostomy in 
spinal cord injury (SCI) patients. Methods: We retrospectively reviewed a 
total of 254 patients with spinal cord injury. Of them, we selected 21 
spinal cord injury patients who required tracheostomy due to long-term 
mechanical ventilation and analyzed their medical records. The patients were 
categorized into two groups. Early tracheostomy was performed day 1-10 from 
intubation in 10 patients and the late tracheostomy was performed after day 
10 in 11 cases. We also evaluated the duration of mechanical ventilation, 
stay in the ICU and complications related to tracheostomy, the injury level 
of and clinical severity. All data was analyzed using SPSS 18.0/WIN. 
Results: The early tracheostomy offered clear advantages for shortening the 
total ICU stay (20.8 day vs. 38.0 day, p=0.010). There was also 
statistically significant reduction in the total length of time on 
mechanical ventilation (5.2 day vs. 29.2 day, p=0.009). However, the 
reductions in the incidence of pneumonia (40% vs. 82%) and the length of ICU 
stay post to tracheostomy (6 day vs. 15 day) were found to be statistically 
not significant. There were also no statistically significant differences in 
the injury level and clinical severity between the groups. Conclusion: We 
concluded that the early tracheostomy (at least 10 days) is beneficial for 
SCI patients who are likely to require prolonged mechanical ventilation. © 
2013 The Korean Neurosurgical Society.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; early intervention; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; artificial ventilation; clinical article; clinical effectiveness; controlled study; disease severity; female; human; intensive care; length of stay; male; pneumonia; postoperative complication (complication); retrospective study; surgical risk; treatment duration; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013716276
PUI
  L370261691
DOI
  10.3340/jkns.2013.54.3.220
FULL TEXT LINK
  http://dx.doi.org/10.3340/jkns.2013.54.3.220
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20053711&id=doi:10.3340%2Fjkns.2013.54.3.220&atitle=The+effectiveness+of+early+tracheostomy+%28within+at+least+10+days%29+in+cervical+spinal+cord+injury+patients&stitle=J.+Korean+Neurosurg.+Soc.&title=Journal+of+Korean+Neurosurgical+Society&volume=54&issue=3&spage=220&epage=224&aulast=Choi&aufirst=Hoi+Jung&auinit=H.J.&aufull=Choi+H.J.&coden=&isbn=&pages=220-224&date=2013&auinit1=H&auinitm=J
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 491
TITLE
  Heavy lifting causing hemorrhagic syrinx with subsequent C2 asia a spinal 
cord injury: A case report
AUTHOR NAMES
  Miller B.A.; Dugan S.E.; Balch J.B.; Polun B.J.; Stambolis V.; Miller B.A.
AUTHOR ADDRESSES
  (Dugan S.E.; Balch J.B.; Polun B.J.; Stambolis V.; Miller B.A.)
(Miller B.A.) Marianjoy, Westchester, United States.
CORRESPONDENCE ADDRESS
  B.A. Miller, Marianjoy, Westchester, United States.
FULL RECORD ENTRY DATE
  2013-11-01
SOURCE
  PM and R (2013) 5:9 SUPPL. 1 (S244). Date of Publication: September 2013
VOLUME
  5
ISSUE
  9
FIRST PAGE
  S244
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  2013 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  National Harbor, MD, United States
CONFERENCE DATE
  2013-10-03 to 2013-10-06
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: 59 year-old female with a long history of type II diabetes 
and hypertension who suffered a C2 ASIA A spinal cord injury following a 
hemorrhagic syrinx while transferring a patient at work. The patient 
presented twice to an emergency department with symptoms of increasing 
extremity weakness and numbness, loss of bowel and bladder function, and 
neck pain. MRI showed a heterogeneous signal from the inferior medulla to 
T3. She was diagnosed with a hemorrhagic syrinx. Two days later, she 
underwent a C1-C7 decompressive laminectomy, had a tracheostomy and PEG tube 
placed, and spent six weeks at a long-term care facility before being sent 
to our acute inpatient rehabilitation hospital. Setting: An acute inpatient 
rehabilitation hospital. Results or Clinical Course: Admission FIM was 48. 
Her tracheostomy tube was eventually capped and later removed. After a month 
of rehabilitation, she was able to navigate terrain utilizing a sip and puff 
system on her power chair, improved her left trapezius elevation to 1/5, and 
improved her right plantar flexion strength to 1/5. She was discharged home 
to continue long-term goals such as modified power chair independence over 
advanced terrain and discerning autonomic dysreflexia signs and symptoms as 
an outpatient. Discussion: A syrinx is often best seen with a sagittal MRI 
and can extend multiple levels, most commonly, the cervical region. 
Presenting symptoms are commonly pain in localized areas and can provide 
lower motor neuron signs at the lesion level, and various sensory 
abnormalities from the lesion and below. Any increase in CSF pressure can 
suddenly increase the syrinx and cause unpredictable results; in our 
patient's case, transferring a heavy load was hypothesized to have torn her 
syrinx causing a hemorrhage. She had no history of neck pain prior to her 
accident and developed neck pain immediately afterwards. A week passed 
before she presented to the ED. She attempted to treat her pain with over 
the counter anti-inflammatory, possibly making matters worse. Conclusions: 
While rare, a syrinx should be on the differential in a patient with a 
headache or backache, especially if accompanied by appropriate level sensory 
changes or lower motor neuron signs.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Asia; case report; human; physical medicine; rehabilitation; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  accident; autonomic dysreflexia; backache; bladder function; bleeding; cerebrospinal fluid; cerebrospinal fluid pressure; disease course; emergency ward; female; headache; hospital; hospital patient; hypertension; independence; intestine; laminectomy; long term care; motoneuron; neck pain; non insulin dependent diabetes mellitus; nuclear magnetic resonance imaging; outpatient; pain; paresthesia; patient; physical disease by body function; tracheostomy; tracheostomy tube; tube; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71205994
DOI
  10.1016/j.pmrj.2013.08.398
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pmrj.2013.08.398
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:10.1016%2Fj.pmrj.2013.08.398&atitle=Heavy+lifting+causing+hemorrhagic+syrinx+with+subsequent+C2+asia+a+spinal+cord+injury%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=5&issue=9&spage=S244&epage=&aulast=Dugan&aufirst=Steven+E.&auinit=S.E.&aufull=Dugan+S.E.&coden=&isbn=&pages=S244-&date=2013&auinit1=S&auinitm=E
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 492
TITLE
  Timing of tracheostomy after anterior cervical spine fixation
AUTHOR NAMES
  Stahel P.F.; Moore T.A.; Vanderheiden T.F.
AUTHOR ADDRESSES
  (Stahel P.F.; Moore T.A.; Vanderheiden T.F.) Department of Orthopaedic 
Surgery Denver Health Medical Center Denver, CO and Department of 
Neurosurgery School of Medicine University of Colorado Aurora, CO Department 
of Orthopaedic Surgery MetroHealth Medical Center Cleveland, OH Department 
of Orthopaedic Surgery Denver Health Medical Center Denver, CO
FULL RECORD ENTRY DATE
  2015-04-03
SOURCE
  The journal of trauma and acute care surgery (2013) 75:3 (538-539). Date of 
Publication: 1 Sep 2013
VOLUME
  75
ISSUE
  3
FIRST PAGE
  538
LAST PAGE
  539
DATE OF PUBLICATION
  1 Sep 2013
ISSN
  2163-0763 (electronic)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  procedures; 
EMTREE MEDICAL INDEX TERMS
  cervical spine; decompression surgery; female; human; male; postoperative complication (epidemiology); spinal cord injury (etiology, surgery); spine fracture (surgery); tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  24089130 (http://www.ncbi.nlm.nih.gov/pubmed/24089130)
PUI
  L603385826
DOI
  10.1097/TA.0b013e3182a040da
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e3182a040da
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0b013e3182a040da&atitle=Timing+of+tracheostomy+after+anterior+cervical+spine+fixation&stitle=J+Trauma+Acute+Care+Surg&title=The+journal+of+trauma+and+acute+care+surgery&volume=75&issue=3&spage=538&epage=539&aulast=Stahel&aufirst=Philip+F.&auinit=P.F.&aufull=Stahel+P.F.&coden=&isbn=&pages=538-539&date=2013&auinit1=P&auinitm=F
COPYRIGHT
  Copyright 2015 Medline is the source for the citation and abstract of this 
record.

RECORD 493
TITLE
  Re: timing of tracheostomy after anterior cervical spine fixation
AUTHOR NAMES
  Bagley C.A.
AUTHOR ADDRESSES
  (Bagley C.A.) Division of Neurosurgery Duke Spine Center Duke University 
School of Medicine Durham, NC
FULL RECORD ENTRY DATE
  2015-04-03
SOURCE
  The journal of trauma and acute care surgery (2013) 75:3 (539). Date of 
Publication: 1 Sep 2013
VOLUME
  75
ISSUE
  3
FIRST PAGE
  539
DATE OF PUBLICATION
  1 Sep 2013
ISSN
  2163-0763 (electronic)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  procedures; 
EMTREE MEDICAL INDEX TERMS
  cervical spine; decompression surgery; female; human; male; postoperative complication (epidemiology); spinal cord injury (etiology, surgery); spine fracture (surgery); tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  24089131 (http://www.ncbi.nlm.nih.gov/pubmed/24089131)
PUI
  L603385837
DOI
  10.1097/TA.0b013e31829e1efe
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e31829e1efe
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:10.1097%2FTA.0b013e31829e1efe&atitle=Re%3A+timing+of+tracheostomy+after+anterior+cervical+spine+fixation&stitle=J+Trauma+Acute+Care+Surg&title=The+journal+of+trauma+and+acute+care+surgery&volume=75&issue=3&spage=539&epage=&aulast=Bagley&aufirst=Carlos+A.&auinit=C.A.&aufull=Bagley+C.A.&coden=&isbn=&pages=539-&date=2013&auinit1=C&auinitm=A
COPYRIGHT
  Copyright 2015 Medline is the source for the citation and abstract of this 
record.

RECORD 494
TITLE
  Intracranial hemorrhage after spine surgery Clinical article
AUTHOR NAMES
  Kaloostian P.E.; Kim J.E.; Bydon A.; Sciubba D.M.; Wolinsky J.-P.; Gokaslan Z.L.; Witham T.F.
AUTHOR ADDRESSES
  (Kaloostian P.E., paul_kaloostian@hotmail.com; Kim J.E.; Bydon A.; Sciubba 
D.M.; Wolinsky J.-P.; Gokaslan Z.L.; Witham T.F.) Department of Neurological 
Surgery, Johns Hopkins Hospital, Meyer 7-109, 600 N. Wolfe St., Baltimore, 
MD 21287, United States.
CORRESPONDENCE ADDRESS
  P.E. Kaloostian, Department of Neurological Surgery, Johns Hopkins Hospital, 
Meyer 7-109, 600 N. Wolfe St., Baltimore, MD 21287, United States. Email: 
paul_kaloostian@hotmail.com
AiP/IP ENTRY DATE
  2013-09-30
FULL RECORD ENTRY DATE
  2013-10-02
SOURCE
  Journal of Neurosurgery: Spine (2013) 19:3 (370-380). Date of Publication: 
September 2013
VOLUME
  19
ISSUE
  3
FIRST PAGE
  370
LAST PAGE
  380
DATE OF PUBLICATION
  September 2013
ISSN
  1547-5654
  1547-5646 (electronic)
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Object. The authors describe the largest case series of 8 patients with 
intracranial hemorrhage (ICH) after spinal surgery and identify associated 
pre-, intra-, and postoperative risk factors in relation to outcome. 
Methods. The authors retrospectively reviewed the cases of 8 patients 
treated over 16 years at a single institution and also reviewed the existing 
literature and collected demographic, treatment, and outcome information 
from 33 unique cases of remote ICH after spinal surgery. Results. The risk 
factors most correlated with ICH postoperatively were the presence of a CSF 
leak intraoperatively and the use of drains postoperatively with moderate 
hourly serosanguineous output in the early postoperative period. 
Conclusions. Intracranial hemorrhage is a rare complication of spinal 
surgery that is associated with CSF leakage and use of drains 
postoperatively, with moderate serosanguinous output. These associations do 
not justify a complete avoidance of drains in patients with CSF leakage but 
may guide the treating physician to keep in mind drain output and timing of 
drain removal, while noting any changes in neurological examination status 
in the meantime. Additionally, continued and worsening neurological symptoms 
after spinal surgery may warrant cranial imaging to rule out intracranial 
hemorrhage, usually within the first 24 hours after surgery. The presence of 
cerebellar hemorrhage and hydrocephalus indicated a trend toward worse 
outcome. © AANS, 2013.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain hemorrhage (complication, surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; anastomosis; ankylosing spondylitis (surgery); article; ataxic aphasia; backache; cancer chemotherapy; clinical article; cognition; compression fracture (surgery); computer assisted tomography; confusion; conservative treatment; craniotomy; decompression; dysphagia; female; headache; human; hydrocephalus; hypertension; immunosuppressive treatment; intervertebral disk hernia (surgery); intraoperative period; kidney transplantation; kyphoscoliosis (surgery); laminectomy; limb weakness; liquorrhea (complication); lumbar stenosis (surgery); male; motor performance; neck pain; neurogenic bladder; neurologic examination; osteosarcoma (surgery); parietal lobe; pelvic osteosarcoma (surgery); postoperative period; postural headache; preoperative period; pseudarthrosis; radiculopathy; renal osteodystrophy; retrospective study; risk factor; scoliosis (surgery); seizure; spinal cord compression; spine malformation (complication); spondylolisthesis (surgery); stenosis (surgery); subdural hematoma (surgery); surgical drainage; tracheostomy; treatment outcome; ventilator; wound drainage; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Cancer (16)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013596851
MEDLINE PMID
  23848351 (http://www.ncbi.nlm.nih.gov/pubmed/23848351)
PUI
  L369865749
DOI
  10.3171/2013.6.SPINE12863
FULL TEXT LINK
  http://dx.doi.org/10.3171/2013.6.SPINE12863
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475654&id=doi:10.3171%2F2013.6.SPINE12863&atitle=Intracranial+hemorrhage+after+spine+surgery+Clinical+article&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=19&issue=3&spage=370&epage=380&aulast=Kaloostian&aufirst=Paul+E.&auinit=P.E.&aufull=Kaloostian+P.E.&coden=&isbn=&pages=370-380&date=2013&auinit1=P&auinitm=E
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 495
TITLE
  Complications after long posterior instrumentation patients with 
cervicothoracic fractures related to ankylosing spine disease: A prospective 
study in 41 consecutive patients
AUTHOR NAMES
  Robinson Y.; Robinson A.-L.; Olerud C.
AUTHOR ADDRESSES
  (Robinson Y.; Robinson A.-L.; Olerud C.) Uppsala University Hospital, 
Uppsala, Sweden.
CORRESPONDENCE ADDRESS
  Y. Robinson, Uppsala University Hospital, Uppsala, Sweden.
FULL RECORD ENTRY DATE
  2014-02-17
SOURCE
  European Spine Journal (2013) 22:5 SUPPL. 1 (S660). Date of Publication: 
September 2013
VOLUME
  22
ISSUE
  5
FIRST PAGE
  S660
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  EuroSpine Annual Meeting 2013
CONFERENCE LOCATION
  Liverpool, United Kingdom
CONFERENCE DATE
  2013-10-02 to 2013-10-04
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background: Fractures of the cervicothoracic region related to ankylosing 
spondylitis (AS) and diffuse idiopathic spinal hyperostosis (DISH) are 
menacing both sagittal profile and spinal cord. Furthermore low soft tissue 
covering may lead to increased postoperative infections. Until now there are 
only few case series published in this regard. The aim of this study is to 
investigate the common practice of long posterior instrumentation of 
cervicothoracic fractures with regard to per- and postoperative 
complications. Methods: During the years 2007 to 2011 41 patients (35 men, 6 
women, mean age 71 ± 12 years [48, 95]) with fractures of the 
cervicothoracic junction related to AS (n = 31) or DISH (n = 10) were 
treated by posterior instrumentation. 6 patients were smokers. 30 patients 
had no neurological deficit, 1 was classified Frankel D, 4 Frankel C and 6 
Frankel A. All patients were followed prospectively for two years using the 
standardised protocol of the Swedish Spine Registry SWESPINE. Mortality data 
was obtained from the Swedish Mortality register. Results: 90 % of the 
instrumentations were cranially extending to C2, 5 % to C1 and 5 % to 
occiput. Caudally in 44 % the instrumentation ended at Th3, in 27 % at Th2. 
5 patients suffered from postoperative infections, 3 patients suffered from 
postoperative pneumonia, 2 patients required postoperative tracheostomy, and 
1 patient had postoperative liquor leakage due to accidental durotomy. At 
one-year follow-up the patients reported a neck-pain of 24 ± 25 and an 
arm-pain of 21 ± 24 on the 100 points VAS scale. Neck pain improved after 2 
years to 14 ± 18 VAS. No patient required re-operation due to implant 
failure or non-union during the first two years. Mean survival was 52 months 
[95 % CI: 42, 62]. Survival was significantly affected by patient age, 
gender, smoking, spinal cord injury, and dementia. Outcome and survival were 
not affected by the type of ankylosing disease or levels of fixation. 
Discussion: Patients with ankylosing disease suffering from a fracture of 
the cervicothoracic region are at high risk of developing postoperative 
complications. These can be complicated by co-morbidity of this rather 
elderly group of patients. The posterior instrumentation technique is 
providing sufficient stability allowing early mobilisation, and has lead to 
stable fusion in all patients in the investigated group. Therefore posterior 
instrumentation of fractures related to ankylosing spondylitis can be 
recommended.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis; devices; fracture; human; patient; prospective study; spine disease; 
EMTREE MEDICAL INDEX TERMS
  aged; arm pain; case study; dementia; female; follow up; gender; hyperostosis; implant; male; morbidity; mortality; neck pain; pneumonia; postoperative complication; postoperative infection; pseudarthrosis; register; risk; smoking; soft tissue; spinal cord; spinal cord injury; spine; survival; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71314840
DOI
  10.1007/s00586-013-2944-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-013-2944-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-013-2944-9&atitle=Complications+after+long+posterior+instrumentation+patients+with+cervicothoracic+fractures+related+to+ankylosing+spine+disease%3A+A+prospective+study+in+41+consecutive+patients&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=22&issue=5&spage=S660&epage=&aulast=Robinson&aufirst=Yohan&auinit=Y.&aufull=Robinson+Y.&coden=&isbn=&pages=S660-&date=2013&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 496
TITLE
  Scoring risk factors to early wound dehiscence and progression to metalwork 
infections after instrumented spinal fusion in children with neuromuscular 
scoliosis
AUTHOR NAMES
  Bashir M.A.; Athanassacopoulos M.; Hunt R.; Leong J.; Ember T.; Lucas J.; Nadarajah R.
AUTHOR ADDRESSES
  (Bashir M.A.; Athanassacopoulos M.; Hunt R.; Leong J.; Ember T.; Lucas J.; 
Nadarajah R.) Paediatric Spinal Surgery, London, United Kingdom.
CORRESPONDENCE ADDRESS
  M.A. Bashir, Paediatric Spinal Surgery, London, United Kingdom.
FULL RECORD ENTRY DATE
  2014-02-17
SOURCE
  European Spine Journal (2013) 22:5 SUPPL. 1 (S673). Date of Publication: 
September 2013
VOLUME
  22
ISSUE
  5
FIRST PAGE
  S673
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  EuroSpine Annual Meeting 2013
CONFERENCE LOCATION
  Liverpool, United Kingdom
CONFERENCE DATE
  2013-10-02 to 2013-10-04
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Abstract title: Scoring Risk Factors to Early Wound Dehiscence and 
Progression to Metalwork Infections after Instrumented Spinal Fusion in 
Children with Neuromuscular Scoliosis Aims: 1. Identifying and scoring risk 
factors that predict early wound dehiscence and progression to metalwork 
infection. 2. Results of wound healing, eradication of infection and union 
of with the use of vacuum dressing. 3. Compare results of serial washouts 
against early vacuum dressing in this group of children with significant 
medical co-morbidities. Method: A retrospective review of 350 patients with 
neuromuscular scoliosis who underwent posterior instrumented correction and 
fusion between 2008 and 2012 at two institutions. 10 patients had an early 
wound dehiscence which progressed to deep seated infection requiring wound 
washout(s) and subsequent vacuum dressing. Medical notes, clinical 
photographs and imaging were reviewed. Minimum follow up period was 14 
months. Results: This study shows that readmission to PICU, presence of 
viscero-cutaneous devices (e.g. PEG, tracheostomy), restrictive lung 
disease, concomitant infection, polymicrobial (gram negative) organism and 
hyperlordotic deformities are cumulative risk factors to developing early 
wound dehiscence leading to deep seated infections. All patients in our 
series went on to have a sealed, non infected wound with union confirmed on 
CT. Patients who had multiple serial washouts (n = 3-7), eventually required 
vacuum dressing. Discussion: By stratifying risk factors in patients with 
neuromuscular scoliosis, the occurrence of wound dehiscence can be 
predicted. With higher risk factor scores, early vacuum dressing is 
recommended as multiple serial wound washouts have poor results and with 
added morbidity to the patient.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child; human; infection; risk factor; scoliosis; spine fusion; wound dehiscence; 
EMTREE MEDICAL INDEX TERMS
  concurrent infection; deformity; devices; follow up; hospital readmission; imaging; lung disease; morbidity; organisms; patient; photography; tracheostomy; vacuum; wound; wound healing; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71314873
DOI
  10.1007/s00586-013-2944-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-013-2944-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-013-2944-9&atitle=Scoring+risk+factors+to+early+wound+dehiscence+and+progression+to+metalwork+infections+after+instrumented+spinal+fusion+in+children+with+neuromuscular+scoliosis&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=22&issue=5&spage=S673&epage=&aulast=Bashir&aufirst=Muhammad+Amer&auinit=M.A.&aufull=Bashir+M.A.&coden=&isbn=&pages=S673-&date=2013&auinit1=M&auinitm=A
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 497
TITLE
  Evaluation of assisted cough with air stacking in patients with tetraplegia
AUTHOR NAMES
  Torres-Castro R.; Vera R.; Monge G.; Suranyi C.; Avilés P.; Vilaró J.
AUTHOR ADDRESSES
  (Torres-Castro R., hackrod@yahoo.com; Monge G., gonzalomonge1@hotmail.com; 
Suranyi C., carolinasuranyi@gmail.com; Avilés P., paliaviles@gmail.com) 
Equipo De Rehabilitación Respiratoria, Clínica Los Coihues, Santiago, Chile.
(Torres-Castro R., hackrod@yahoo.com; Vera R., kinerob@yahoo.com) Escuela De 
Kinesiología, Universidad De Chile, Santiago, Chile.
(Vilaró J., jordi.gestos@gmail.com) Facultad De Ciencias De La Salud 
Blanquerna, Grupo De Investigación En Fisioterapia (GReFis), Universidad 
Ramon Llull, Barcelona, Spain.
CORRESPONDENCE ADDRESS
  R. Torres-Castro, Equipo De Rehabilitación Respiratoria, Clínica Los 
Coihues, Santiago, Chile. Email: hackrod@yahoo.com
FULL RECORD ENTRY DATE
  2015-04-20
SOURCE
  European Respiratory Journal (2013) 42 SUPPL. 57. Date of Publication: 1 Sep 
2013
VOLUME
  42
DATE OF PUBLICATION
  1 Sep 2013
CONFERENCE NAME
  European Respiratory Society Annual Congress 2013
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2013-09-07 to 2013-09-11
ISSN
  0903-1936
BOOK PUBLISHER
  European Respiratory Society
ABSTRACT
  INTRODUCTION: A significant number of patients with tetraplegia require 
prolonged mechanical ventilation and use of tracheostomy. For an effective 
weaning, a thorough analysis of the ability to cough is required. The cough 
effectiveness is related to the peak cough flow (PCF). Lower PCF values has 
been described as ineffective and are associated with a greater risk of 
pulmonary infections. There are techniques to assist cough by increasing the 
inspiratory volume and the expiratory flow. The manual Air Stacking (AS) 
technique has been proven as effective in neuromuscular disease. OBJECTIVE: 
to assess cough efficacy using air stacking and manual compression in 
patients with tetraplegia with A ASIA Score. METHODS: 11 hospitalized 
patients with tetraplegia (A ASIA Score) were selected. Measures: PCF during 
four different interventions: spontaneous maximal expiratory effort (MEE); 
MEE while receiving abdominal compression (MEE+Abd); MEE after air stacking 
with a manual resuscitation bag (MEE+AS); and MEE with air stacking and 
compression (MEE+Add+AS). RESULTS: median age 33 years (16-56 years). The 
PCF during the different interventions was: MEE 156±53 L/min; MEE+Abd 
235±113 L/min; MEE+AS 225±61 L/min, and MEE+Abd+AS 303±96 L/min. We observed 
PCF increase while applying combination techniques but only significant 
differences existed between PCF with MEE and MEE+Abd+AS (p=0.0001). 
CONCLUSION: According to our results, patients with spinal cord injury 
presented an ineffective cough constituting a risk factor for developing 
respiratory symptoms. The application of combined techniques (MEE+Abd+AS) 
can reach near normal PCF values. Those are low cost, simple and easy 
applied intervention.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing muscle; chronic disease; coughing; European; human; patient; quadriplegia; society; 
EMTREE MEDICAL INDEX TERMS
  American Spinal Injury Association impairment scale; artificial ventilation; book; compression; expiratory flow; hospital patient; lung infection; neuromuscular disease; resuscitation; risk; risk factor; spinal cord injury; tracheostomy; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71843481
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09031936&id=doi:&atitle=Evaluation+of+assisted+cough+with+air+stacking+in+patients+with+tetraplegia&stitle=Eur.+Respir.+J.&title=European+Respiratory+Journal&volume=42&issue=&spage=&epage=&aulast=Torres-Castro&aufirst=Rodrigo&auinit=R.&aufull=Torres-Castro+R.&coden=&isbn=&pages=-&date=2013&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 498
TITLE
  Diaphragmatic pacing: Facilitating early rehabilitation through early 
ventilator weaning
AUTHOR NAMES
  Acho T.; Young M.; Alfonso L.
AUTHOR ADDRESSES
  (Acho T.; Young M.; Alfonso L.) Rehabilitation Institute of Michigan, 
Detroit, United States.
CORRESPONDENCE ADDRESS
  T. Acho, Rehabilitation Institute of Michigan, Detroit, United States.
FULL RECORD ENTRY DATE
  2013-11-26
SOURCE
  Journal of Spinal Cord Medicine (2013) 36:5 SPEC. ISSUE (528). Date of 
Publication: September 2013
VOLUME
  36
ISSUE
  5
FIRST PAGE
  528
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  Academy of Spinal Cord Injury Professionals Educational Conference 2013, 
ASCIP 2013
CONFERENCE LOCATION
  Las Vegas, NV, United States
CONFERENCE DATE
  2013-09-02 to 2013-09-04
ISSN
  1079-0268
BOOK PUBLISHER
  Maney Publishing
ABSTRACT
  Objective: To describe two cases in which diaphragmatic pacer placement 
facilitated early discharge from acute care and to discuss the benefits of 
early rehabilitation in spinal cord injury (SCI). Many high-level 
tetraplegic patients require ventilator assistance, thus preventing active 
participation in an acute rehabilitation program. Ventilator weaning often 
leads to prolonged acute care stays and delayed initiation of 
rehabilitation. This promotes further deconditioning and increases the risks 
of SCI-related complications. Case 1: An 18-year-old Native-American man 
involved in a motor vehicle accident (MVA) leaving him with C4 AIS A 
tetraplegia with motor preservation up to C5 initially. A tracheostomy was 
placed and patient had subsequent difficulty weaning off the ventilator. On 
hospital day 37, he underwent diaphragmatic pacer placement. On day 67, he 
was transferred to inpatient rehabilitation and pacer was turned off on day 
104. Rather than spending 104 days in acute care, inpatient rehabilitation 
was started 37 days earlier. He became modified independent with power 
wheelchair mobility and setup with basic activities of daily living. Case 2: 
A 60-year-old Caucasian man involved in a MVA, resulting in C3 AIS A 
tetraplegia. Tracheostomy was placed on day 6. Difficultly weaning from the 
ventilator lead to diaphragmatic pacer placement on day 21. Patient was 
transferred to inpatient rehabilitation on day 52. On day 130, pacer weaning 
was initiated and achieved by day 151. This resulted in 99 days of 
rehabilitation that was initiated prior to complete ventilator independence. 
He became modified independent with power wheelchair mobility and verbally 
independent to instruct his care. Conclusion: Early weaning reduces 
ventilator-associated infections, leads to earlier rehabilitation, prevents 
the effects of deconditioning, and promotes early patient and family 
education. This helps prevent SCI-related complications including 
contractures, pressure sores, deep vein thrombosis, urinary tract 
infections, autonomic dysreflexia, and orthostatic hypotension. 
Neuropsychological intervention and interaction with other patients with SCI 
are established earlier, providing coping resources to aid in successful 
rehabilitation. In conclusion, diaphragmatic pacers allow patients to spend 
less time in acute care and transition earlier to inpatient rehabilitation. 
This promotes earlier discharge to the community with less complications, 
better outcomes, and improved quality of life.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; rehabilitation; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  American Indian; autonomic dysreflexia; Caucasian; community; contracture; coping behavior; daily life activity; decubitus; deep vein thrombosis; education; emergency care; hospital; hospital patient; human; independence; infection; male; orthostatic hypotension; patient; preservation; quadriplegia; quality of life; risk; tracheostomy; traffic accident; urinary tract infection; ventilator; weaning; wheelchair; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71232167
DOI
  10.1179/1079026813Z.000000000207
FULL TEXT LINK
  http://dx.doi.org/10.1179/1079026813Z.000000000207
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1179%2F1079026813Z.000000000207&atitle=Diaphragmatic+pacing%3A+Facilitating+early+rehabilitation+through+early+ventilator+weaning&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=36&issue=5&spage=528&epage=&aulast=Acho&aufirst=Tamara&auinit=T.&aufull=Acho+T.&coden=&isbn=&pages=528-&date=2013&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 499
TITLE
  Timing of tracheostomy after anterior cervical spine fixation.
AUTHOR NAMES
  Stahel P.F.; Moore T.A.; Vanderheiden T.F.
AUTHOR ADDRESSES
  (Stahel P.F.) Department of Orthopaedic Surgery Denver Health Medical Center 
Denver, CO and Department of Neurosurgery School of Medicine University of 
Colorado Aurora, CO Department of Orthopaedic Surgery MetroHealth Medical 
Center Cleveland, OH Department of Orthopaedic Surgery Denver Health Medical 
Center Denver, CO.
(Moore T.A.; Vanderheiden T.F.)
CORRESPONDENCE ADDRESS
  P.F. Stahel, Department of Orthopaedic Surgery Denver Health Medical Center 
Denver, CO and Department of Neurosurgery School of Medicine University of 
Colorado Aurora, CO Department of Orthopaedic Surgery MetroHealth Medical 
Center Cleveland, OH Department of Orthopaedic Surgery Denver Health Medical 
Center Denver, CO.
FULL RECORD ENTRY DATE
  2014-01-13
SOURCE
  The journal of trauma and acute care surgery (2013) 75:3 (538-539). Date of 
Publication: Sep 2013
VOLUME
  75
ISSUE
  3
FIRST PAGE
  538
LAST PAGE
  539
DATE OF PUBLICATION
  Sep 2013
ISSN
  2163-0763 (electronic)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; decompression surgery; postoperative complication (epidemiology); spinal cord injury (etiology, surgery); spine fracture (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  female; human; injury; male; methodology; note; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  24089130 (http://www.ncbi.nlm.nih.gov/pubmed/24089130)
PUI
  L563005267
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:&atitle=Timing+of+tracheostomy+after+anterior+cervical+spine+fixation.&stitle=J+Trauma+Acute+Care+Surg&title=The+journal+of+trauma+and+acute+care+surgery&volume=75&issue=3&spage=538&epage=539&aulast=Stahel&aufirst=Philip+F&auinit=P.F.&aufull=Stahel+P.F.&coden=&isbn=&pages=538-539&date=2013&auinit1=P&auinitm=F
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 500
TITLE
  Re: timing of tracheostomy after anterior cervical spine fixation.
AUTHOR NAMES
  Bagley C.A.
AUTHOR ADDRESSES
  (Bagley C.A.) Division of Neurosurgery Duke Spine Center Duke University 
School of Medicine Durham, NC.
CORRESPONDENCE ADDRESS
  C.A. Bagley, Division of Neurosurgery Duke Spine Center Duke University 
School of Medicine Durham, NC.
FULL RECORD ENTRY DATE
  2014-01-13
SOURCE
  The journal of trauma and acute care surgery (2013) 75:3 (539). Date of 
Publication: Sep 2013
VOLUME
  75
ISSUE
  3
FIRST PAGE
  539
DATE OF PUBLICATION
  Sep 2013
ISSN
  2163-0763 (electronic)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; decompression surgery; postoperative complication (epidemiology); spinal cord injury (etiology, surgery); spine fracture (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  female; human; injury; male; methodology; note; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  24089131 (http://www.ncbi.nlm.nih.gov/pubmed/24089131)
PUI
  L563005268
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630763&id=doi:&atitle=Re%3A+timing+of+tracheostomy+after+anterior+cervical+spine+fixation.&stitle=J+Trauma+Acute+Care+Surg&title=The+journal+of+trauma+and+acute+care+surgery&volume=75&issue=3&spage=539&epage=&aulast=Bagley&aufirst=Carlos+A&auinit=C.A.&aufull=Bagley+C.A.&coden=&isbn=&pages=539-&date=2013&auinit1=C&auinitm=A
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 501
TITLE
  Percutaneous endoscopic gastrostomy (PEG) feeding tube migration into the 
colon. an unusual complication following acute spinal cord injury: A case 
report
AUTHOR NAMES
  Grove S.; Almoshelli B.; Colachis S.; Grove S.
AUTHOR ADDRESSES
  (Almoshelli B.; Colachis S.; Grove S.)
(Grove S.) Ohio State University, Wexner Medical Center, Columbus, United 
States.
CORRESPONDENCE ADDRESS
  S. Grove, Ohio State University, Wexner Medical Center, Columbus, United 
States.
FULL RECORD ENTRY DATE
  2013-11-01
SOURCE
  PM and R (2013) 5:9 SUPPL. 1 (S268). Date of Publication: September 2013
VOLUME
  5
ISSUE
  9
FIRST PAGE
  S268
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  2013 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  National Harbor, MD, United States
CONFERENCE DATE
  2013-10-03 to 2013-10-06
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: A 19-year-old man was involved in a motor vehicle crash 
resulting in T4 complete paraplegia (AIS A). Associated injuries included a 
ruptured spleen requiring splenectomy, bilateral pneumothoraces with 
respiratory failure, and a right femur fracture requiring surgical fixation. 
Both a PEG and a tracheostomy tube were placed due to prolonged ventilatory 
support and nutritional requirements. Eight weeks following his injury he 
was successfully weaned from the ventilator and over the next two weeks was 
advanced to a regular diet. At that time he was admitted to inpatient 
rehabilitation and was no longer using the PEG tube. Four days after 
admission, he complained of mild left upper quadrant abdominal pain; his 
examination was unremarkable. Computed Tomography (CT) of the abdomen 
identified tenting of the stomach. A dedicated radiograph with contrast 
revealed that the PEG tube was located outside of the stomach and within the 
colon with fistula formation between his colon and stomach.Program 
Description: Percutaneous endoscopic gastrostomy (PEG) tube migration with 
gastro-colonic fistula formation. Setting: Academic Medical Center. Results 
or Clinical Course: The surgical consultants recommended removal of the PEG 
tube which was performed at the bedside. He was monitored closely for signs 
of peritonitis which did not occur. The remainder of his rehabilitation was 
unremarkable and he was discharged home after successfully completing the 
inpatient program. Discussion: Patients with complete spinal cord injuries 
have altered perception of pain and limited clinical signs of intraabdominal 
pathology making diagnosis of potentially serious complications very 
difficult. Close attention to vague abdominal or referred symptoms in this 
population is critical to allow timely diagnosis and treatment. Conclusions: 
This unusual case of PEG tube migration illustrates the importance of close 
attention to vague abdominal or referred symptoms in patients with SCI and 
altered sensation in order to optimize early detection and treatment of 
potentially serious abdominal pathology.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; feeding apparatus; human; percutaneous endoscopic gastrostomy; physical medicine; rehabilitation; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  abdomen; abdominal pain; colon fistula; computer assisted tomography; consultation; diagnosis; diet; disease course; examination; femur fracture; fistula; hospital patient; injury; male; motor vehicle; nutritional requirement; pain; paraplegia; pathology; patient; peritonitis; population; respiratory failure; sensation; spleen; splenectomy; stomach; stomach tube; tracheostomy tube; tube; university hospital; ventilator; X ray film; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71206055
DOI
  10.1016/j.pmrj.2013.08.459
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pmrj.2013.08.459
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:10.1016%2Fj.pmrj.2013.08.459&atitle=Percutaneous+endoscopic+gastrostomy+%28PEG%29+feeding+tube+migration+into+the+colon.+an+unusual+complication+following+acute+spinal+cord+injury%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=5&issue=9&spage=S268&epage=&aulast=Almoshelli&aufirst=Bader&auinit=B.&aufull=Almoshelli+B.&coden=&isbn=&pages=S268-&date=2013&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 502
TITLE
  Helicopter transportation of a sedated, mechanically ventilated patient with 
cervical cord injury
AUTHOR NAMES
  Kato H.; Nishiwaki Y.; Hosoi K.; Shiomi N.; Hirata M.
AUTHOR ADDRESSES
  (Kato H.; Nishiwaki Y.; Hirata M.) Department of Anesthesiology, Saiseikai 
Shiga Hospital, Ritto 520-3046, Japan.
(Hosoi K.) Department of Orthopedics, Saiseikai Shiga Hospital, Ritto 
520-3046, Japan.
(Shiomi N.) Department of Emergency, Saiseikai Shiga Hospital, Ritto 
520-3046, Japan.
CORRESPONDENCE ADDRESS
  Department of Anesthesiology, Saiseikai Shiga Hospital, Ritto 520-3046, 
Japan.
AiP/IP ENTRY DATE
  2013-09-25
FULL RECORD ENTRY DATE
  2013-09-27
SOURCE
  Japanese Journal of Anesthesiology (2013) 62:9 (1127-1131). Date of 
Publication: September 2013
VOLUME
  62
ISSUE
  9
FIRST PAGE
  1127
LAST PAGE
  1131
DATE OF PUBLICATION
  September 2013
ISSN
  0021-4892
BOOK PUBLISHER
  Kokuseido Publishing Co. Ltd, 23-5-202 Hongo, 3-chome, Bunkyo-ku, Tokyo, 
Japan.
ABSTRACT
  We report helicopter transportation of a sedated, mechanically ventilated 
patient with cervical cord injury. A 20-year-old male sustained traumatic 
injury to the cervical spinal cord during extracurricular activities in a 
college. On arrival at the hospital, a halo vest was placed on the patient 
and tracheostomy was performed. On the 38th hospital day, he was transported 
a distance of 520 km by helicopter to a specialized hospital in Fukuoka for 
medical repatriation. Cabin space was narrow. Since power supply and 
carrying capacity were limited, battery-driven and portable medical devices 
were used. In consideration for patient's psychological stress, he was 
sedated with propofol. RSS (Ramsay sedation scale) scores were recorded to 
evaluate whether the patient was adequately sedated during helicopter 
transportation. Prior to transport, we rehearsed the sedation using 
bispectral index monitoring (BIS) in the hospital to further ensure the 
patient's safety during the transport.
EMTREE DRUG INDEX TERMS
  propofol; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  air medical transport; artificial ventilation; cervical spinal cord injury; sedation; 
EMTREE MEDICAL INDEX TERMS
  adult; article; bispectral index; case report; halo brace; human; male; mental stress; patient safety; tracheostomy; ventilated patient; 
CAS REGISTRY NUMBERS
  propofol (2078-54-8)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013586032
MEDLINE PMID
  24063142 (http://www.ncbi.nlm.nih.gov/pubmed/24063142)
PUI
  L369829904
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00214892&id=doi:&atitle=Helicopter+transportation+of+a+sedated%2C+mechanically+ventilated+patient+with+cervical+cord+injury&stitle=Jpn.+J.+Anesthesiol.&title=Japanese+Journal+of+Anesthesiology&volume=62&issue=9&spage=1127&epage=1131&aulast=Kato&aufirst=Hideya&auinit=H.&aufull=Kato+H.&coden=MASUA&isbn=&pages=1127-1131&date=2013&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 503
TITLE
  Intramedullary abscess of the upper cervical spinal cord. Unusual 
presentation and dilemmas of management: Case report
AUTHOR NAMES
  Sinha P.; Parekh T.; Pal D.
AUTHOR ADDRESSES
  (Sinha P., priyanksinha@yahoo.com; Pal D.) Department of Neurosurgery, Leeds 
General Infirmary, Leeds LS1 3EX, United Kingdom.
(Parekh T.) School of Medicine, University of Leeds, United Kingdom.
CORRESPONDENCE ADDRESS
  P. Sinha, Department of Neurosurgery, Leeds General Infirmary, Leeds LS1 
3EX, United Kingdom. Email: priyanksinha@yahoo.com
AiP/IP ENTRY DATE
  2013-02-28
FULL RECORD ENTRY DATE
  2013-11-22
SOURCE
  Clinical Neurology and Neurosurgery (2013) 115:9 (1845-1850). Date of 
Publication: September 2013
VOLUME
  115
ISSUE
  9
FIRST PAGE
  1845
LAST PAGE
  1850
DATE OF PUBLICATION
  September 2013
ISSN
  0303-8467
  1872-6968 (electronic)
BOOK PUBLISHER
  Elsevier, P.O. Box 211, Amsterdam, Netherlands.
EMTREE DRUG INDEX TERMS
  C reactive protein (endogenous compound); ceftriaxone (drug therapy, intravenous drug administration); meropenem (drug therapy, intravenous drug administration); vancomycin (drug therapy, intrathecal drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abscess (drug therapy, drug therapy, surgery); brain ventriculitis (drug therapy, drug therapy, surgery); cervical spinal cord; 
EMTREE MEDICAL INDEX TERMS
  adult; antibiotic therapy; article; astrocytoma (diagnosis); brain ventricle peritoneum shunt; case report; cerebrospinal fluid analysis; cerebrospinal fluid culture; cerebrospinal fluid drainage; cervical spine radiography; computer assisted tomography; cordotomy; cranial nerve; demyelinating disease (diagnosis); differential diagnosis; echocardiography; ependymoma (diagnosis); female; flaccid paralysis; Glasgow coma scale; Gram positive cocci; human; hydrocephalus (diagnosis); lateral brain ventricle; leukocyte count; mean arterial pressure; medical history; nuclear magnetic resonance imaging; protein blood level; pus; spinal cord infection (drug therapy); Streptococcus milleri; tracheostomy; urine culture; ventriculostomy catheter; weakness; 
CAS REGISTRY NUMBERS
  C reactive protein (9007-41-4)
  ceftriaxone (73384-59-5, 74578-69-1)
  meropenem (96036-03-2)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013719406
MEDLINE PMID
  23453154 (http://www.ncbi.nlm.nih.gov/pubmed/23453154)
PUI
  L52462860
DOI
  10.1016/j.clineuro.2013.01.008
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clineuro.2013.01.008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03038467&id=doi:10.1016%2Fj.clineuro.2013.01.008&atitle=Intramedullary+abscess+of+the+upper+cervical+spinal+cord.+Unusual+presentation+and+dilemmas+of+management%3A+Case+report&stitle=Clin.+Neurol.+Neurosurg.&title=Clinical+Neurology+and+Neurosurgery&volume=115&issue=9&spage=1845&epage=1850&aulast=Sinha&aufirst=Priyank&auinit=P.&aufull=Sinha+P.&coden=CNNSB&isbn=&pages=1845-1850&date=2013&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 504
TITLE
  Anesthesia and spinal muscle atrophy
AUTHOR NAMES
  Islander G.
AUTHOR ADDRESSES
  (Islander G., gunilla.islander@skane.se) Department of Intensive and 
Perioperative Care, Skåne University Hospital, SE-22185 Lund, Sweden.
CORRESPONDENCE ADDRESS
  G. Islander, Department of Intensive and Perioperative Care, Skåne 
University Hospital, SE-22185 Lund, Sweden. Email: gunilla.islander@skane.se
AiP/IP ENTRY DATE
  2013-05-01
FULL RECORD ENTRY DATE
  2013-08-26
SOURCE
  Paediatric Anaesthesia (2013) 23:9 (804-816). Date of Publication: September 
2013
  Special themed issue on Anesthesia and muscle disease in children, Book 
Series Title:
VOLUME
  23
ISSUE
  9
FIRST PAGE
  804
LAST PAGE
  816
DATE OF PUBLICATION
  September 2013
ISSN
  1155-5645
  1460-9592 (electronic)
BOOK PUBLISHER
  Blackwell Publishing Ltd, 9600 Garsington Road, Oxford, United Kingdom.
ABSTRACT
  Spinal muscle atrophy (SMA) is autosomal recessive and one of the most 
common inherited lethal diseases in childhood. The spectrum of symptoms of 
SMA is continuous and varies from neonatal death to progressive symmetrical 
muscle weakness first appearing in adulthood. The disease is produced by 
degeneration of spinal motor neurons and can be described in three or more 
categories: SMA I with onset of symptoms before 6 months of age; SMAII with 
onset between 6 and 18 months and SMA III, which presents later in 
childhood. Genetics: The disease is in more than 95% of cases caused by a 
homozygous deletion in survival motor neuron gene 1 (SMN1). Pathophysiology: 
The loss of full-length functioning SMN protein leads to a degeneration of 
anterior spinal motor neurons which causes muscle weakness. Anesthetic 
risks: Airway: Tracheal intubation can be difficult. Respiration: Infants 
with SMA I almost always need postoperative respiratory support. Patients 
with SMA II sometimes need support, while SMA III patients seldom need 
support. Circulation: Circulatory problems during anesthesia are rare. 
Anesthetic drugs: Neuromuscular blockers: Patients with SMA may display 
increased sensitivity to and prolonged effect of nondepolarizing 
neuromuscular blockers. Intubation without muscle relaxation should be 
considered. Succinylcholine should be avoided. Opioids: These should be 
titrated carefully. Anesthetic techniques: All types of anesthetic technique 
have been used. Although none is absolutely contraindicated, none is 
perfect: anesthesia must be individualized. Conclusion: The perioperative 
risks can be considerable and are mainly related to the respiratory system, 
from respiratory failure to difficult/impossible intubation. © 2013 John 
Wiley & Sons Ltd.
EMTREE DRUG INDEX TERMS
  methadone (drug therapy); remifentanil (drug therapy); riluzole (drug therapy); survival motor neuron protein 1 (endogenous compound); survival motor neuron protein 2 (endogenous compound); suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; spinal muscular atrophy (drug therapy, diagnosis, drug therapy, 
epidemiology, etiology, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis (drug therapy); artificial ventilation; assisted ventilation; blood clotting disorder; bulbar paralysis; cesarean section; congestive cardiomyopathy; drug withdrawal; endotracheal intubation; gastrostomy; general anesthesia; heart arrest; heart disease; human; immobilization; joint contracture; kyphoscoliosis; lung clearance; lung disease; lung function; medical ethics; motoneuron; motor performance; muscle relaxation; muscle weakness; nerve cell degeneration; neuromuscular transmission; nonhuman; noninvasive ventilation; osteopenia; phenotype; postoperative care; prenatal diagnosis; priority journal; proprioceptive feedback; quality of life; regional anesthesia; resuscitation; review; RNA processing; stem cell transplantation; stomach fundoplication; sudden infant death syndrome; thrombosis; tracheostomy; tracheotomy; 
CAS REGISTRY NUMBERS
  methadone (1095-90-5, 125-56-4, 23142-53-2, 297-88-1, 76-99-3)
  remifentanil (132539-07-2)
  riluzole (1744-22-5)
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013507413
MEDLINE PMID
  23601145 (http://www.ncbi.nlm.nih.gov/pubmed/23601145)
PUI
  L52557787
DOI
  10.1111/pan.12159
FULL TEXT LINK
  http://dx.doi.org/10.1111/pan.12159
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11555645&id=doi:10.1111%2Fpan.12159&atitle=Anesthesia+and+spinal+muscle+atrophy&stitle=Paediatr.+Anaesth.&title=Paediatric+Anaesthesia&volume=23&issue=9&spage=804&epage=816&aulast=Islander&aufirst=Gunilla&auinit=G.&aufull=Islander+G.&coden=PAANF&isbn=&pages=804-816&date=2013&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 505
TITLE
  A report of 41 cases of three-column osteotomies of the upper thoracic spine 
and cervicothoracic junction: Complications, outcomes and differential 
impact on Spinal pelvic parameters, cervical sagittal alignment and general 
health status
AUTHOR NAMES
  Tabaraee E.; Theologis A.A.; Funao H.; Bess R.S.; Klineberg E.O.; Smith J.S.; Kebaish K.M.; Deviren V.; Ames C.P.
AUTHOR ADDRESSES
  (Tabaraee E.; Deviren V.; Ames C.P.) University of California San Francisco, 
San Francisco, United States.
(Theologis A.A.) University of California San Francisco, San Francisco 
General Hospital Orthopaedic Trauma Institute, San Francisco, United States.
(Bess R.S.) Department of Orthopedic Surgery, Johns Hopkins Hospital, 
Baltimore, United States.
(Funao H.) Rocky Mountain Scoliosis and Spine, Denver, United States.
(Klineberg E.O.) University of California, Davis School of Medicine, 
Sacramento, United States.
(Smith J.S.) UVA Health System, Charlottesville, United States.
(Kebaish K.M.) Baltimore, United States.
CORRESPONDENCE ADDRESS
  E. Tabaraee, University of California San Francisco, San Francisco, United 
States.
FULL RECORD ENTRY DATE
  2013-10-04
SOURCE
  Spine Journal (2013) 13:9 SUPPL. 1 (4S-5S). Date of Publication: September 
2013
VOLUME
  13
ISSUE
  9
FIRST PAGE
  4S
LAST PAGE
  5S
DATE OF PUBLICATION
  September 2013
CONFERENCE NAME
  28th Annual Meeting of the North American Spine Society, NASS 2013
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2013-10-09 to 2013-10-12
ISSN
  1529-9430
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  BACKGROUND CONTEXT: Vertebral column resection (VCR) and pedicle subtraction 
osteotomies (PSO) are most commonly performed at or below the mid thoracic 
apex to lower lumbar spine. Evidence regarding three-column osteotomies of 
the upper thoracic spine and cervicothoracic junction are limited. PURPOSE: 
This study details and compares complications, radiographic, and clinical 
outcomes of lower cervical and upper thoracic three-column osteotomies. 
STUDY DESIGN/SETTING: A retrospective analysis of patients who underwent 
either a lower cervical (C-6 or C-7) or upper thoracic (T-1 through T-5) 
3-column osteotomy (VCR or PSO) for proximal junction kyphosis, fixed 
cervical sagittal deformity, or posttraumatic kyphosis. PATIENT SAMPLE: 
Forty-one patients (mean age 60) with average follow- up of 15 months 
underwent 20 VCRs and 21 PSOs. There were 15 lower cervical and 26 upper 
thoracic three-column osteotomies. METHODS: Parametric outcomes were 
analyzed using student t-tests. RESULTS: Average estimated blood loss (1228 
vs 1232 cc) and number of fusion levels (10) were similar. Operative time 
for the lower cervical three-column osteotomies was shorter (251 vs 328 
minutes, p=0.013. The lower cervical osteotomy group had longer ICU (5.6 vs 
2.3 days) and hospital (14.5 vs 8 days) stays (p=0.99 and 0.175 
respectively). For the lower cervical osteotomy group, average preoperative 
global sagittal vertical axis (SVA), C2-7 SVA, cervical lordosis and pelvic 
tilt (PT) was 1.1 cm (-6.1 to +11.6), 7.9 cm (4.3-13), 21° of kyphosis (0 to 
-49) and 23.9° (8-43°). Postoperative global SVA, C2-7 SVA, cervical 
lordosis and postop PT was 3 cm (-5 to 8.7), 4.7 cm (1.8-7.5), 18° of 
lordosis (1 to 46) and 21°(7-43) respectively. For the upper thoracic 
osteotomy group, average preoperative global sagittal vertical axis (SVA), 
C2-7 SVA, cervical lordosis, and pelvic tilt (PT) was 4.25 cm (-2.7 to 
16.6), 5.2 cm (0.5 to 8.4), 20.6° (-16 to 44), and 27° (8-50). Postoperative 
global SVA, C2-7 SVA, cervical lordosis, and postop PT were 3.9 cm (-1.6 to 
19.2), 4 cm (1.2 to 7.2), 18.4° (-43 to 52), and 25° (8-35) respectively. 
Overall, the lower cervical osteotomies provided greater correction in 
cervical SVA (p=0.03) and C2-T1 angle (p<0.001) only. Preoperative SF-12 
physical component scores (PCS) for the lower cervical and upper thoracic 
groups were 30.5 and 38 respectively. Postoperative scores were 32.4 and 
46.7. The upper thoracic group showed greater improvement, however this was 
not statistically significant (p=0.5). There were no differences in 
reoperation rates (20% vs 15%, p=0.7) between the groups. The lower cervical 
group had 3 (20%) reoperations done for 2 pseudarthroses, 1 infection, and 1 
case of distal junctional kyphosis (DJK). Rates of medical complications in 
the lower cervical osteotomy group were higher (40% vs 8%, p5.034). This 
included 3 patients with respiratory failure requiring tracheotomy, 1 
permanent dysphagia and 2 deep venous thromboses (DVT). In the upper 
thoracic group, 4 (15%) reoperations were done for 1 pseudoarthrosis, 1 
infection, 1 DJK and adjacent segment stenosis. One patient had dysphagia 
and one had a DVT. Three patients in this group had asymptomatic remote site 
rod fracture without a subsequent reoperation. CONCLUSIONS: Three-column 
osteotomies at the cervicothoracic junction and upper thoracic spine restore 
regional sagittal alignment. Lower cervical osteotomies produce greater 
correction of C2-C7 SVA and cervical lordosis with shorter operative time. 
Length of stay and medical complications rates were higher. In this study, 
upper thoracic 3-column osteotomies did not show significant radiographic 
changes in cervical or spinopelvic parameters. However, there were less 
medical complications, shorter stay and trend toward greater improvements in 
general health status PCS.
EMTREE DRUG INDEX TERMS
  hexamethonium bromide; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health status; osteotomy; parameters; pelvis; society; spine; thoracic spine; 
EMTREE MEDICAL INDEX TERMS
  bleeding; deep vein thrombosis; deformity; dysphagia; follow up; fracture; hospital; human; infection; kyphosis; length of stay; lordosis; lumbar spine; operation duration; patient; pseudarthrosis; reoperation; respiratory failure; stenosis; Student t test; surgery; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71177210
DOI
  10.1016/j.spinee.2013.07.041
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.spinee.2013.07.041
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15299430&id=doi:10.1016%2Fj.spinee.2013.07.041&atitle=A+report+of+41+cases+of+three-column+osteotomies+of+the+upper+thoracic+spine+and+cervicothoracic+junction%3A+Complications%2C+outcomes+and+differential+impact+on+Spinal+pelvic+parameters%2C+cervical+sagittal+alignment+and+general+health+status&stitle=Spine+J.&title=Spine+Journal&volume=13&issue=9&spage=4S&epage=5S&aulast=Tabaraee&aufirst=Ehsan&auinit=E.&aufull=Tabaraee+E.&coden=&isbn=&pages=4S-5S&date=2013&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 506
TITLE
  Cerebellar hemorrhage from a delayed cervical spine hardware migration
AUTHOR NAMES
  Chalouhi N.; Chitale A.; Tjoumakaris S.; Gonzalez L.F.; Theofanis T.; Jabbour P.
AUTHOR ADDRESSES
  (Chalouhi N.; Chitale A.; Tjoumakaris S.; Gonzalez L.F.; Theofanis T.; 
Jabbour P., pascal.jabbour@jefferson.edu) Department of Neurological 
Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, 
Thomas Jefferson University Hospital, 901 Walnut Street, Philadelphia 19107, 
United States.
CORRESPONDENCE ADDRESS
  P. Jabbour, Department of Neurological Surgery, Division of Neurovascular 
Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, 
901 Walnut Street, Philadelphia 19107, United States. Email: 
pascal.jabbour@jefferson.edu
AiP/IP ENTRY DATE
  2013-05-27
FULL RECORD ENTRY DATE
  2013-11-22
SOURCE
  Clinical Neurology and Neurosurgery (2013) 115:9 (1894-1896). Date of 
Publication: September 2013
VOLUME
  115
ISSUE
  9
FIRST PAGE
  1894
LAST PAGE
  1896
DATE OF PUBLICATION
  September 2013
ISSN
  0303-8467
  1872-6968 (electronic)
BOOK PUBLISHER
  Elsevier, P.O. Box 211, Amsterdam, Netherlands.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cerebellum hemorrhage (complication, diagnosis); medical device complication; spine fusion implant; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; computer assisted tomography; female; human; intensive care unit; magnetic resonance angiography; medical history; nuclear magnetic resonance imaging; posterior fossa; skull defect; tracheostomy; vascular lesion; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013719343
MEDLINE PMID
  23707142 (http://www.ncbi.nlm.nih.gov/pubmed/23707142)
PUI
  L52596417
DOI
  10.1016/j.clineuro.2013.05.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clineuro.2013.05.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03038467&id=doi:10.1016%2Fj.clineuro.2013.05.003&atitle=Cerebellar+hemorrhage+from+a+delayed+cervical+spine+hardware+migration&stitle=Clin.+Neurol.+Neurosurg.&title=Clinical+Neurology+and+Neurosurgery&volume=115&issue=9&spage=1894&epage=1896&aulast=Chalouhi&aufirst=Nohra&auinit=N.&aufull=Chalouhi+N.&coden=CNNSB&isbn=&pages=1894-1896&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 507
TITLE
  Long-term ventilation in children: Longitudinal trends and outcomes
AUTHOR NAMES
  McDougall C.M.; Adderley R.J.; Wensley D.F.; Seear M.D.
AUTHOR ADDRESSES
  (McDougall C.M., catherine.mcdougall@nhs.net; Wensley D.F.; Seear M.D.) 
Division of Respiratory Medicine, British Columbia's Children's Hospital, 
Vancouver, BC, Canada.
(Adderley R.J.; Wensley D.F.; Seear M.D.) Division of Critical Care, British 
Columbia's Children's Hospital, Vancouver, BC, Canada.
CORRESPONDENCE ADDRESS
  C.M. McDougall, Department of Respiratory Paediatrics, Royal Hospital for 
Sick Children, Sciennes Road, Edinburgh EH9 1LF, United Kingdom. Email: 
catherine.mcdougall@nhs.net
AiP/IP ENTRY DATE
  2013-08-12
FULL RECORD ENTRY DATE
  2013-09-04
SOURCE
  Archives of Disease in Childhood (2013) 98:9 (660-665). Date of Publication: 
September 2013
VOLUME
  98
ISSUE
  9
FIRST PAGE
  660
LAST PAGE
  665
DATE OF PUBLICATION
  September 2013
ISSN
  0003-9888
  1468-2044 (electronic)
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  Background Cross-sectional studies have suggested a rapid expansion in 
paediatric long-term ventilation (LTV) over the last 20 years but 
information on longitudinal trends is limited. Methods Data were collected 
prospectively on all patients receiving LTV over a 15-year period 
(1.1.95-31.12.09) in a single regional referral centre. Results 144 children 
commenced LTV during the 15- year period. The incidence of LTV increased 
significantly over time, with an accompanying 10-fold increase in prevalence 
due to a significant increase in institution of non-invasive ventilation 
(NIV). There was no significant increase in invasive ventilation. 5-year 
survival was 94% overall and was significantly higher for patients on NIV 
(97%) than invasively ventilated patients (84%). 10-year survival was 91% 
overall. Although some children were able to discontinue respiratory support 
(21% at 5 years and 42% at 10 years), the number of patients transitioned to 
adult services increased significantly over time (26% of total cohort). 
Patients with neuromuscular disease were less likely to discontinue support 
than other patients. Conclusions The paediatric LTV population has expanded 
significantly over 15 years. Future planning of paediatric hospital and 
community services, as well as adult services, must take into account the 
needs of this growing population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; long term care; long term ventilation; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; assisted ventilation; cervical spinal cord injury; child; congenital central hypoventilation syndrome (therapy); cross-sectional study; diaphragm paralysis (therapy); Duchenne muscular dystrophy (therapy); female; human; incidence; infant; kyphoscoliosis (therapy); Langerhans cell histiocytosis (therapy); lung hypoplasia (therapy); major clinical study; male; mortality; myopathy (therapy); neuromuscular disease (therapy); noninvasive ventilation; outcome assessment; positive end expiratory pressure; preschool child; prevalence; priority journal; prospective study; school child; sleep disordered breathing (therapy); spinal muscular atrophy (therapy); spine injury (therapy); survival; tracheobronchomalacia (therapy); tracheostomy; ventilated patient; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013538351
MEDLINE PMID
  23838128 (http://www.ncbi.nlm.nih.gov/pubmed/23838128)
PUI
  L52720865
DOI
  10.1136/archdischild-2012-303062
FULL TEXT LINK
  http://dx.doi.org/10.1136/archdischild-2012-303062
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039888&id=doi:10.1136%2Farchdischild-2012-303062&atitle=Long-term+ventilation+in+children%3A+Longitudinal+trends+and+outcomes&stitle=Arch.+Dis.+Child.&title=Archives+of+Disease+in+Childhood&volume=98&issue=9&spage=660&epage=665&aulast=McDougall&aufirst=Catherine+M.&auinit=C.M.&aufull=McDougall+C.M.&coden=ADCHA&isbn=&pages=660-665&date=2013&auinit1=C&auinitm=M
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 508
TITLE
  Application of a sponaneous ventilation protocol: Experiences from a weaning 
center for neurological diseases
ORIGINAL (NON-ENGLISH) TITLE
  Anwendung eines standardisierten Spontanatmungsprotokolls: Erfahrungen in 
einem Weaning-Zentrum mit neurologischem Schwerpunkt
AUTHOR NAMES
  Oehmichen F.; Zäumer K.; Ragaller M.; Mehrholz J.; Pohl M.
AUTHOR ADDRESSES
  (Oehmichen F., frank.oehmichen@klinik-bavaria.de; Zäumer K.; Mehrholz J.; 
Pohl M.) Fach- und Privatkrankenhaus, Klinik Bavaria Kreischa, An der 
Wolfsschlucht 1-2, 01731 Kreischa, Germany.
(Ragaller M.) Klinik und Poliklinik für Anästhesie und Intensivtherapie, 
Technische Universität Dresden, Dresden, Germany.
CORRESPONDENCE ADDRESS
  F. Oehmichen, Fach- und Privatkrankenhaus, Klinik Bavaria Kreischa, An der 
Wolfsschlucht 1-2, 01731 Kreischa, Germany. Email: 
frank.oehmichen@klinik-bavaria.de
AiP/IP ENTRY DATE
  2013-07-04
FULL RECORD ENTRY DATE
  2013-10-04
SOURCE
  Nervenarzt (2013) 84:8 (962-972). Date of Publication: August 2013
VOLUME
  84
ISSUE
  8
FIRST PAGE
  962
LAST PAGE
  972
DATE OF PUBLICATION
  August 2013
ISSN
  0028-2804
  1433-0407 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Objective: The aim of this study was to investigate a novel standardized 
protocol in this neurological weaning unit in order to optimize the weaning 
process for patients subjected to prolonged mechanical ventilation. Of 
primary interest were the frequency of and reasons for deviating from the 
protocol as well as risk factors for weaning failure and mortality. Patients 
and methods: All patients admitted to the weaning unit were enrolled in this 
prospective observational study. The weaning protocol consisted of 22 
discrete weaning steps. An individual weaning approach was only begun if the 
standardized protocol failed. Variables for risk analysis included age, body 
mass index, APACHE II score, reason for initiating mechanical ventilation, 
total duration of inpatient stay before admission to the weaning unit, 
extent of mechanical ventilation period before admission, chronic pulmonary 
diseases and dialysis. Results: Between October 2007 and December 2008 a 
total of 644 consecutively admitted patients were enrolled in the study. The 
mean age was 67.6 ± 12.3 years, the mean inpatient stay before admission was 
45.8 ± 34.9 days and the mean duration of mechanical ventilation before 
admission to the unit was 38.1 ± 28.7 days. The mean APACHE II score was 
19.0 ± 7.2, 68 % of the patients were male, 98.6 % had a tracheotomy tube, 
30.9 % had a history of chronic pulmonary disease and 13.7 % required 
dialysis. Reasons for initiating ventilation were cerebral 33.1 %, pulmonary 
28.7 %, cardiovascular 31.5 %, neuropathic 2.8 %, myopathic 0.9 %, spinal 
cord injuries 1.9 % and 1.1 % were unclear. Weaning was successful in 77.3 % 
(498 patients) of all cases with a mean duration of 22.0 ± 33.9 days. Of 
those successfully weaned, a total of 85.9 % (n = 428) were weaned according 
to the standard protocol. The weaning process was also shorter (20.8 ± 35.6 
versus 29.0 ± 19.9 days) for those patients weaned according to the protocol 
compared to those patients where the protocol failed. Protocol failure was 
normally due to complications during the weaning process. Among the patients 
where the protocol failed, chronic pulmonary disease (41.4 versus 28.3 %; p 
< 0.02), a longer duration of ventilation (42.3 ± 22.8 versus 35.9 ± 25.3 
days; p < 0.01) and a longer in-hospital stay (52.7 ± 41.4 versus 42.4 ± 
30.1 days; p < 0.01) prior to admission were significantly more common. A 
total of 23.0 % (n = 148) of the patients died and 9.8 % (n = 63) of the 
patients were discharged into a home care ventilation program. Chronic 
pulmonary disease and the duration of inpatient stay prior to admission were 
predictors of weaning failure. The APACHE II score, age and acute renal 
failure with concomitant need for dialysis were the factors best predicting 
mortality. Conclusions: The majority of patients receiving prolonged 
mechanical ventilation can be successfully weaned using a standardized 
protocol. Failures of standardized weaning per protocol occurred most often 
in patients with chronic pulmonary disease and following longer inpatient 
stay. These patients also had a higher risk of final weaning failure. © 2013 
Springer-Verlag Berlin Heidelberg.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; chronic lung disease (therapy); myopathy; neuropathy; spinal cord injury; treatment withdrawal; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (therapy); age; aged; article; body mass; dialysis; female; hospital patient; human; major clinical study; male; mortality; observational study; risk factor; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  2013600568
MEDLINE PMID
  23821290 (http://www.ncbi.nlm.nih.gov/pubmed/23821290)
PUI
  L52661302
DOI
  10.1007/s00115-013-3812-x
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00115-013-3812-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00282804&id=doi:10.1007%2Fs00115-013-3812-x&atitle=Application+of+a+sponaneous+ventilation+protocol%3A+Experiences+from+a+weaning+center+for+neurological+diseases&stitle=Nervenarzt&title=Nervenarzt&volume=84&issue=8&spage=962&epage=972&aulast=Oehmichen&aufirst=F.&auinit=F.&aufull=Oehmichen+F.&coden=NERVA&isbn=&pages=962-972&date=2013&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 509
TITLE
  Effect of ethnicity and insurance type on the outcome of open thoracic 
aortic aneurysm repair
AUTHOR NAMES
  Murphy E.H.; Stanley G.A.; Arko M.Z.; Davis III C.M.; Modrall J.G.; Arko III F.R.
AUTHOR ADDRESSES
  (Murphy E.H.; Stanley G.A.; Arko M.Z.; Davis III C.M.; Modrall J.G.; Arko 
III F.R., frank.arko@carolinashealthcare.org) Department of Surgery, 
Southwestern Medical Center, University of Texas, Dallas, TX, United States.
CORRESPONDENCE ADDRESS
  F.R. Arko III, Sanger Heart and Vascular Institute, 1001 Blythe Boulevard, 
Charlotte, NC 28203, United States. Email: 
frank.arko@carolinashealthcare.org
AiP/IP ENTRY DATE
  2013-03-28
FULL RECORD ENTRY DATE
  2013-08-12
SOURCE
  Annals of Vascular Surgery (2013) 27:6 (699-707). Date of Publication: 
August 2013
VOLUME
  27
ISSUE
  6
FIRST PAGE
  699
LAST PAGE
  707
DATE OF PUBLICATION
  August 2013
ISSN
  0890-5096
  1615-5947 (electronic)
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Objectives: Mortality and complication rates for open thoracic aortic 
aneurysm repair have declined but remain high. The purpose of this study is 
to determine the influence of ethnicity and insurance type on procedure 
selection and outcome after open thoracic aneurysm repair. Methods: Using 
the Nationwide Inpatient Sample database, ethnicity and insurance type were 
evaluated against the outcome variables of mortality and major complications 
associated with open thoracic aneurysm repair. The potential cofounders of 
age, gender, urgency of operation, and Deyo index of comorbidities were 
controlled. Results: Between 2001 and 2005, a total of 10,557 patients were 
identified who underwent elective open thoracic aneurysm repair, with a 
significantly greater proportion of white patients (n = 8524) compared with 
black patients (n = 819), Hispanic patients (n = 556), and patients 
categorized as other (n = 658). Most patients (67%) were male. Almost half 
(45%) of the procedures were performed for urgent/emergent indications. 
Overall mortality was 10.7% (n = 1126) and the rate of spinal cord ischemia 
was 0.4% (n = 43). Univariate analysis revealed significant differences 
among race with regard to surgery type, income, hospital region, hospital 
bed size, and insurance type (P < 0.0001). Differences between insurance 
coverage were significant for gender, surgery type, income, hospital region, 
and race (P < 0.0001). Bivariate analysis by race revealed differences for 
death (P < 0.0001), pneumonia (P < 0.0001), renal complications (P = 0.011), 
implant complications (P < 0.0001), temporary tracheostomy (P = 0.004), 
transfusion (P < 0.0001), and intubation (P < 0.0001). In terms of payer 
status, bivariate analysis by insurance coverage revealed differences in 
death (P < 0.0001), central nervous system complications (P = 0.008), 
pneumonia (P < 0.0001), myocardial infarction (P = 0.001), infection (P < 
0.0001), renal complications (P < 0.0001), malnutrition (P < 0.0001), 
temporary tracheostomy (P < 0.0001), spinal cord ischemia (P = 0.001), 
transfusion (P < 0.0001), and intubation (P < 0.0001). Conclusions: A high 
percentage of open thoracic procedures (45%) are performed urgently or 
emergently in the United States, which is associated with increased 
morbidity and mortality. Both ethnicity and payer status were associated 
with significant differences in surgical outcomes, including mortality and 
frequency of complications after open thoracic aortic aneurysm repair. © 
2013 Elsevier Inc. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ethnicity; health insurance; thoracic aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  article; central nervous system disease (complication); comorbidity; digestive system disease (complication); endovascular aneurysm repair; female; heart infarction (complication); Hispanic; hospital bed capacity; human; intubation; kidney disease (complication); major clinical study; male; malnutrition (complication); medicaid; medicare; mortality; peripheral vascular disease (complication); pneumonia (complication); postoperative complication (complication); postoperative infection (complication); priority journal; private health insurance; race difference; respiratory tract disease (complication); spinal cord ischemia (complication); tracheostomy; transfusion; treatment outcome; vascular disease (complication); 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013471131
MEDLINE PMID
  23540667 (http://www.ncbi.nlm.nih.gov/pubmed/23540667)
PUI
  L52510066
DOI
  10.1016/j.avsg.2012.08.011
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.avsg.2012.08.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08905096&id=doi:10.1016%2Fj.avsg.2012.08.011&atitle=Effect+of+ethnicity+and+insurance+type+on+the+outcome+of+open+thoracic+aortic+aneurysm+repair&stitle=Ann.+Vasc.+Surg.&title=Annals+of+Vascular+Surgery&volume=27&issue=6&spage=699&epage=707&aulast=Murphy&aufirst=Erin+H.&auinit=E.H.&aufull=Murphy+E.H.&coden=AVSUE&isbn=&pages=699-707&date=2013&auinit1=E&auinitm=H
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 510
TITLE
  Phrenic nerve palsy associated with brachial plexus avulsion in a pediatric 
patient with multitrauma
AUTHOR NAMES
  Karaoǧlu P.; Yiş U.; Öztura I.; Akdoǧan O.; Bayram E.; Topçu Y.; Hz S.
AUTHOR ADDRESSES
  (Karaoǧlu P., pakizekaraoglu@gmail.com; Yiş U.; Bayram E.; Topçu Y.; Hz S.) 
Department of Pediatric Neurology, Dokuz Eylul University Medical School, 
35340, Inciralti, Izmir, Turkey.
(Öztura I.) Department of Neurology, Dokuz Eylul University Medical School, 
Izmir, Turkey.
(Akdoǧan O.) Department of Neurology, Mustafa Kemal Paşa State Hospital, 
Bursa, Turkey.
CORRESPONDENCE ADDRESS
  P. Karaoǧlu, Department of Pediatric Neurology, Dokuz Eylul University 
Medical School, 35340, Inciralti, Izmir, Turkey. Email: 
pakizekaraoglu@gmail.com
FULL RECORD ENTRY DATE
  2013-09-10
SOURCE
  Pediatric Emergency Care (2013) 29:8 (922-923). Date of Publication: August 
2013
VOLUME
  29
ISSUE
  8
FIRST PAGE
  922
LAST PAGE
  923
DATE OF PUBLICATION
  August 2013
ISSN
  0749-5161
  1535-1815 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Although brachial plexus injury occurring during multitrauma is frequent in 
adults, it is rarely observed in childhood. The most common cause of 
pediatric traumatic brachial palsy is motor vehicle accidents followed by 
pedestrian struck. Generally, phrenic nerve palsy accompanying brachial 
plexus trauma is observed in 10% to 20% of cases, but it is overlooked 
because unilateral injuries are frequently asymptomatic. Severe unilateral 
phrenic nerve palsy accompanying brachial plexus avulsion is very rare. 
Here, we present a pediatric case of unilateral phrenic nerve palsy 
associated with respiratory distress and brachial plexus avulsion due to 
multitrauma. Copyright © 2013 by Lippincott Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  inotropic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brachial plexus injury; nerve paralysis; phrenic nerve; phrenic nerve paralysis; 
EMTREE MEDICAL INDEX TERMS
  article; bradycardia; case report; cervical spinal cord injury; child; computer assisted tomography; diaphragm paralysis; dyspnea; electromyography; encephalomalacia; female; femur fracture (surgery); fluoroscopy; follow up; fracture reduction; Glasgow coma scale; hematoma; human; humerus fracture (surgery); hypotension; intensive care unit; laceration; nuclear magnetic resonance imaging; pneumothorax; postoperative period; preschool child; respiratory distress; resuscitation; skull fracture (surgery); tachypnea; thorax radiography; thorax tube; tracheotomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013547722
MEDLINE PMID
  23925250 (http://www.ncbi.nlm.nih.gov/pubmed/23925250)
PUI
  L369706124
DOI
  10.1097/PEC.0b013e31829ec20b
FULL TEXT LINK
  http://dx.doi.org/10.1097/PEC.0b013e31829ec20b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07495161&id=doi:10.1097%2FPEC.0b013e31829ec20b&atitle=Phrenic+nerve+palsy+associated+with+brachial+plexus+avulsion+in+a+pediatric+patient+with+multitrauma&stitle=Pediatr.+Emerg.+Care&title=Pediatric+Emergency+Care&volume=29&issue=8&spage=922&epage=923&aulast=Karao%C7%A7lu&aufirst=Pakize&auinit=P.&aufull=Karao%C7%A7lu+P.&coden=PECAE&isbn=&pages=922-923&date=2013&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 511
TITLE
  Characterizing the need for tracheostomy placement and decannulation after 
cervical spinal cord injury
AUTHOR NAMES
  Nakashima H.; Yukawa Y.; Imagama S.; Ito K.; Hida T.; Machino M.; Kanbara S.; Morita D.; Hamajima N.; Ishiguro N.; Kato F.
AUTHOR ADDRESSES
  (Nakashima H., hirospine@gmail.com; Imagama S.; Hida T.; Ishiguro N.) 
Department of Orthopaedic Surgery, Nagoya University Hospital, Graduate 
School of Medicine, 65 Tsurumai, Shouwa-ku, Nagoya, Aichi 466-8560, Japan.
(Yukawa Y.; Ito K.; Machino M.; Kanbara S.; Morita D.; Kato F.) Department 
of Orthopaedic Surgery, Chubu Rosai Hospital, Nagoya, Japan.
(Hamajima N.) Department of Preventive Medicine, Nagoya University, Graduate 
School of Medicine, Nagoya, Japan.
CORRESPONDENCE ADDRESS
  H. Nakashima, Department of Orthopaedic Surgery, Nagoya University Hospital, 
Graduate School of Medicine, 65 Tsurumai, Shouwa-ku, Nagoya, Aichi 466-8560, 
Japan. Email: hirospine@gmail.com
AiP/IP ENTRY DATE
  2013-04-09
FULL RECORD ENTRY DATE
  2013-07-22
SOURCE
  European Spine Journal (2013) 22:7 (1526-1532). Date of Publication: July 
2013
VOLUME
  22
ISSUE
  7
FIRST PAGE
  1526
LAST PAGE
  1532
DATE OF PUBLICATION
  July 2013
ISSN
  0940-6719
  1432-0932 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Purpose: There have been few reports on the risk factors for tracheostomy 
and the possibility of patients for decannulation. The purpose of this study 
was to identify factors necessitating tracheostomy after cervical spinal 
cord injury (SCI) and detect features predictive of successful decannulation 
in tracheostomy patients. Methods: One hundred and sixty four patients with 
cervical fracture/dislocation were retrospectively reviewed. The patients 
comprised 142 men and 22 women with a mean age of 44.9 years. The clinical 
records were reviewed for patients' demographic data, smoking history, level 
of cervical spine injury, injury patterns, neurological status, evidence of 
direct thoracic trauma and head injury, tracheostomy placement, and 
decannulation. Risk factors necessitating tracheostomy and factors 
predicting decannulation were statistically analysed. Results: Twenty-five 
patients (15.2 %) required tracheostomy. Twenty-one patients were 
successfully decannulated. Smoking history (relative risk [RR], 3.05; p = 
0.03) and complete SCI irrespective of injury level (C1-4 complete SCI: RR, 
67.55; p < 0.001, C5-7 complete SCI: RR, 57.88; p < 0.001) were significant 
risk factors necessitating tracheostomy. C1-4 complete SCI was more frequent 
among those who could not be decannulated. However, even in patients with 
high cervical complete SCI at the time of injury, patients regaining 
sufficient movement to shrug their shoulders within 3 weeks after injury 
could later be decannulated. Conclusions: The risk factors for tracheostomy 
after complete SCI were a history of smoking and complete paralysis 
irrespective of the level of injury. High cervical level complete SCI was 
found to be a risk factor for the failure of decannulation in patients 
without shoulder shrug within 3 weeks after injury. © 2013 Springer-Verlag 
Berlin Heidelberg.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cannulation; cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cervical spine; cervical spine dislocation; cervical spine fracture; controlled study; female; human; injury severity; major clinical study; male; medical record review; priority journal; smoking; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013430700
MEDLINE PMID
  23558580 (http://www.ncbi.nlm.nih.gov/pubmed/23558580)
PUI
  L52523512
DOI
  10.1007/s00586-013-2762-0
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-013-2762-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-013-2762-0&atitle=Characterizing+the+need+for+tracheostomy+placement+and+decannulation+after+cervical+spinal+cord+injury&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=22&issue=7&spage=1526&epage=1532&aulast=Nakashima&aufirst=Hiroaki&auinit=H.&aufull=Nakashima+H.&coden=ESJOE&isbn=&pages=1526-1532&date=2013&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 512
TITLE
  Challenges in the surgical management of spine trauma in the morbidly obese 
patient: A case series
AUTHOR NAMES
  Rosenfeld H.E.; Limb R.; Chan P.; Fitzgerald M.; Bradley W.P.L.; Rosenfeld J.V.
AUTHOR ADDRESSES
  (Rosenfeld H.E.) Medical Faculty, University of Adelaide, Australia.
(Limb R.; Chan P.; Rosenfeld J.V., j.rosenfeld@alfred.org.au) Department of 
Neurosurgery, Australia.
(Fitzgerald M.) Trauma Service, Alfred Hospital, Melbourne, Australia.
(Bradley W.P.L.) Department of Anaesthesia, Monash University, Alfred 
Hospital, Melbourne, Australia.
(Bradley W.P.L.; Rosenfeld J.V., j.rosenfeld@alfred.org.au) Department of 
Surgery, Monash University, Melbourne, Australia.
CORRESPONDENCE ADDRESS
  Medical Faculty, University of Adelaide, Australia.
AiP/IP ENTRY DATE
  2013-07-19
FULL RECORD ENTRY DATE
  2013-07-24
SOURCE
  Journal of Neurosurgery: Spine (2013) 19:1 (101-109). Date of Publication: 
July 2013
VOLUME
  19
ISSUE
  1
FIRST PAGE
  101
LAST PAGE
  109
DATE OF PUBLICATION
  July 2013
ISSN
  1547-5654
  1547-5646 (electronic)
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Object. The treatment of morbidly obese individuals with spine trauma 
presents unique challenges to spine surgeons and trauma staff. This study 
aims to increase awareness of current limitations in the surgical management 
of spine trauma in morbidly obese individuals, and to illustrate practical 
solutions. Methods. Six morbidly obese patients were treated surgically for 
spine trauma over a 2-year period at a single trauma center in Australia. 
All patients were involved in high-speed motor vehicle accidents and had 
multisystem injuries. All weighed in excess of 265 pounds (120 kg) with a 
body mass index ≥ 40 (range 47.8-67.1). Cases were selected according to the 
considerable challenges they presented in all aspects of their management. 
Results. Best medical and surgical care may be compromised and outcome 
adversely affected in morbidly obese patients with spine trauma. The time 
taken to perform all aspects of care is usually extended, often by many 
hours. Customized orthotics may be required. Imaging quality is often 
compromised and patients may not fit into scanners. Surgical challenges 
include patient positioning, surgical access, confirmation of the anatomical 
level, and obtaining adequate instrument length. Postoperative nursing care, 
wound healing, and venous thromboembolism prophylaxis are also significant 
issues. Conclusions. Management pathways and hospital guidelines should be 
developed to optimize the treatment of morbidly obese patients, but 
innovative solutions may be required for individual cases. © AANS, 2013.
EMTREE DRUG INDEX TERMS
  pregabalin (drug therapy); warfarin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  morbid obesity; spine injury (surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; anterior spine fusion; article; artificial ventilation; atelectasis; body mass; body weight; case study; clinical article; compartment syndrome (surgery); computer assisted tomography; deep vein thrombosis (complication, drug therapy); diagnostic imaging; discectomy; dysphonia (complication); emergency health service; endotracheal intubation; extravasation; fasciotomy; female; flail chest; fluid resuscitation; follow up; fracture dislocation (surgery); fracture immobilization; fracture reduction; heart contusion; hematothorax; human; hypotension (therapy); hypoxia (complication); image intensifier; image quality; intensive care unit; laminectomy; male; medical record review; myotome; neck pain; neuropathic pain (complication, drug therapy); nuclear magnetic resonance imaging; nursing care; odontoid process fracture (surgery); open reduction (procedure); orthotics; osteosynthesis; patient monitoring; patient positioning; patient safety; perioperative period; plate fixation; pneumothorax; posterior spine fusion; postoperative care; practice guideline; quadriplegia (complication); recurrent laryngeal nerve palsy; repeat procedure; residential care; resuscitation; retrospective study; spinal cord injury (surgery, therapy); sternotomy; thorax drainage; thorax pain; tracheostomy; traffic accident; vertebra dislocation (surgery); vocal cord paralysis (complication); wound healing; 
CAS REGISTRY NUMBERS
  pregabalin (148553-50-8)
  warfarin (129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2)
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013436416
MEDLINE PMID
  23692604 (http://www.ncbi.nlm.nih.gov/pubmed/23692604)
PUI
  L369299388
DOI
  10.3171/2013.4.SPINE12876
FULL TEXT LINK
  http://dx.doi.org/10.3171/2013.4.SPINE12876
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475654&id=doi:10.3171%2F2013.4.SPINE12876&atitle=Challenges+in+the+surgical+management+of+spine+trauma+in+the+morbidly+obese+patient%3A+A+case+series&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=19&issue=1&spage=101&epage=109&aulast=Rosenfeld&aufirst=Hannah+E.&auinit=H.E.&aufull=Rosenfeld+H.E.&coden=&isbn=&pages=101-109&date=2013&auinit1=H&auinitm=E
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 513
TITLE
  Management of Acute Spinal Cord Injury in the Neurocritical Care Unit
AUTHOR NAMES
  Evans L.T.; Lollis S.S.; Ball P.A.
AUTHOR ADDRESSES
  (Evans L.T., Linton.T.Evans@Hitchcock.org; Lollis S.S.; Ball P.A.) Section 
of Neurosurgery, Dartmouth-Hitchcock Medical Center, One Medical Center 
Drive, LBN, NH03756, United States.
(Ball P.A.) Department of Anesthesiology, Dartmouth-Hitchcock Medical 
Center, One Medical Center Drive, LBN, NH 03756, United States.
CORRESPONDENCE ADDRESS
  L.T. Evans, Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, One 
Medical Center Drive, LBN, NH03756, United States. Email: 
Linton.T.Evans@Hitchcock.org
AiP/IP ENTRY DATE
  2013-04-22
FULL RECORD ENTRY DATE
  2013-07-24
SOURCE
  Neurosurgery Clinics of North America (2013) 24:3 (339-347). Date of 
Publication: July 2013
VOLUME
  24
ISSUE
  3
FIRST PAGE
  339
LAST PAGE
  347
DATE OF PUBLICATION
  July 2013
ISSN
  1042-3680
  1558-1349 (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Acute spinal cord injury (SCI) is associated with widespread disturbances 
not only affecting neurologic function but also leading to hemodynamic 
instability and respiratory failure. Traumatic SCI rarely occurs in 
isolation, and frequently is accompanied by trauma to other organ systems. 
Management of individuals with SCI is complex, requiring aggressive 
monitoring and prompt treatment when complications arise. Typically this 
level of care is provided in the neurocritical care unit. This article 
reviews the pathophysiology of the neurologic, cardiovascular, and pulmonary 
derangements following traumatic SCI and their management in the critical 
care setting. © 2013 Elsevier Inc.
EMTREE DRUG INDEX TERMS
  aminophylline (drug therapy); antiinflammatory agent (drug therapy); atropine (drug therapy); captopril (drug therapy); dopamine (pharmacology); erythropoietin (drug therapy); fludrocortisone (drug therapy); ganglioside GM1 (clinical trial, drug therapy, pharmacology); glucocorticoid (pharmacology); glutamate receptor antagonist (drug therapy); heparin (drug therapy); hydralazine (drug therapy); hypertensive agent (drug therapy, pharmacology); inotropic agent (drug therapy); labetalol (drug therapy); low molecular weight heparin (drug therapy); methylprednisolone (clinical trial, drug comparison, drug dose, drug 
therapy); midodrine (drug therapy); naloxone (clinical trial, drug comparison, drug therapy); nifedipine (adverse drug reaction, drug therapy); nimodipine (drug therapy); noradrenalin (pharmacology); oxygen (drug therapy); phenylephrine (adverse drug reaction); placebo; prostaglandin E2 (drug therapy); tirilazad (clinical trial, drug comparison, drug therapy, pharmacology); warfarin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care unit; spinal cord injury (drug therapy, drug therapy, therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; atelectasis (complication); autonomic dysreflexia (complication, drug therapy, prevention); B scan; bradycardia (complication, drug therapy, side effect); cardiovascular disease (complication); cervical spinal cord injury; deep vein thrombosis (complication, diagnosis); dose response; drug dose comparison; drug effect; drug efficacy; drug fatality (side effect); drug megadose; fluid resuscitation; heart arrest (complication); heart arrhythmia (complication); human; hypotension (complication, drug therapy, therapy); incidence; induced hypothermia; intermittent pneumatic compression device; low drug dose; lung embolism (complication, diagnosis); lung ventilation perfusion ratio; neuroprotection; nonhuman; orthostatic hypotension (complication, drug therapy, epidemiology, therapy); pathophysiology; phlebography; pneumonia (complication); prevalence; priority journal; respiratory failure (complication, therapy); respiratory tract intubation; review; spiral computer assisted tomography; therapy effect; tracheostomy; vein thrombosis (complication, diagnosis); venous thromboembolism (complication, drug therapy, epidemiology, 
prevention, therapy); ventilator associated pneumonia (complication); 
CAS REGISTRY NUMBERS
  aminophylline (317-34-0)
  atropine (51-55-8, 55-48-1)
  captopril (62571-86-2)
  dopamine (51-61-6, 62-31-7)
  erythropoietin (11096-26-7)
  fludrocortisone (127-31-1)
  ganglioside GM1 (37758-47-7)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
  hydralazine (304-20-1, 86-54-4)
  labetalol (32780-64-6, 36894-69-6)
  methylprednisolone (6923-42-8, 83-43-2)
  midodrine (3092-17-9, 42794-76-3)
  naloxone (357-08-4, 465-65-6)
  nifedipine (21829-25-4)
  nimodipine (66085-59-4)
  noradrenalin (1407-84-7, 51-41-2)
  oxygen (7782-44-7)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
  prostaglandin E2 (363-24-6)
  tirilazad (110101-66-1, 110101-67-2, 111793-42-1)
  warfarin (129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Clinical and Experimental Pharmacology (30)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013419799
MEDLINE PMID
  23809029 (http://www.ncbi.nlm.nih.gov/pubmed/23809029)
PUI
  L52542653
DOI
  10.1016/j.nec.2013.02.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nec.2013.02.007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10423680&id=doi:10.1016%2Fj.nec.2013.02.007&atitle=Management+of+Acute+Spinal+Cord+Injury+in+the+Neurocritical+Care+Unit&stitle=Neurosurg.+Clin.+North+Am.&title=Neurosurgery+Clinics+of+North+America&volume=24&issue=3&spage=339&epage=347&aulast=Evans&aufirst=Linton+T.&auinit=L.T.&aufull=Evans+L.T.&coden=NCNAF&isbn=&pages=339-347&date=2013&auinit1=L&auinitm=T
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 514
TITLE
  An algorithm for the management of posttraumatic cervical spondyloptosis
AUTHOR NAMES
  Dahdaleh N.S.; Dlouhy B.J.; Greenlee J.D.W.; Smoker W.R.K.; Hitchon P.W.
AUTHOR ADDRESSES
  (Dahdaleh N.S., nader.dahdaleh@northwestern.edu) Department of Neurosurgery 
at Northwestern University, Northwestern Memorial Hospital, 676 N. St. Clair 
Street, Chicago, IL 60611, United States.
(Dlouhy B.J.; Greenlee J.D.W.; Hitchon P.W.) Department of Neurosurgery, 
University of Iowa, Iowa City, IA, United States.
(Smoker W.R.K.) Department of Radiology, University of Iowa, Iowa City, IA, 
United States.
CORRESPONDENCE ADDRESS
  N.S. Dahdaleh, Department of Neurosurgery at Northwestern University, 
Northwestern Memorial Hospital, 676 N. St. Clair Street, Chicago, IL 60611, 
United States. Email: nader.dahdaleh@northwestern.edu
AiP/IP ENTRY DATE
  2013-05-23
FULL RECORD ENTRY DATE
  2013-07-03
SOURCE
  Journal of Clinical Neuroscience (2013) 20:7 (951-957). Date of Publication: 
July 2013
VOLUME
  20
ISSUE
  7
FIRST PAGE
  951
LAST PAGE
  957
DATE OF PUBLICATION
  July 2013
ISSN
  0967-5868
  1532-2653 (electronic)
BOOK PUBLISHER
  Churchill Livingstone, 1-3 Baxter's Place, Leith Walk, Edinburgh, United 
Kingdom.
ABSTRACT
  Posttraumatic cervical spondyloptosis is the most severe form of fracture 
dislocation. Since its occurrence is uncommon, there is no consensus on its 
surgical management. Detailed description of five patients who were 
successfully managed through one approach (posterior or anterior) is 
presented, a review of the current literature is reported, and biomechanics 
is provided. An algorithm for the treatment of cervical spondyloptosis is 
then proposed. © 2013 Elsevier Ltd. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine dislocation (diagnosis, surgery); posttraumatic cervical spondyloptosis (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; anterior spine fusion; article; biomechanics; cervical spinal cord injury; cervical spine radiography; clinical article; computer assisted tomography; disease association; dyspnea; female; human; intraoperative period; magnetic resonance angiography; male; motor evoked potential; neck pain; neurologic examination; percutaneous endoscopic gastrostomy; posterior spine fusion; postoperative period; preoperative period; priority journal; shoulder dislocation; somatosensory evoked potential; spinal cord compression; spine stabilization; surgical approach; tracheostomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013378016
MEDLINE PMID
  23702373 (http://www.ncbi.nlm.nih.gov/pubmed/23702373)
PUI
  L52591399
DOI
  10.1016/j.jocn.2012.08.008
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jocn.2012.08.008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09675868&id=doi:10.1016%2Fj.jocn.2012.08.008&atitle=An+algorithm+for+the+management+of+posttraumatic+cervical+spondyloptosis&stitle=J.+Clin.+Neurosci.&title=Journal+of+Clinical+Neuroscience&volume=20&issue=7&spage=951&epage=957&aulast=Dahdaleh&aufirst=Nader+S.&auinit=N.S.&aufull=Dahdaleh+N.S.&coden=JCNUE&isbn=&pages=951-957&date=2013&auinit1=N&auinitm=S
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 515
TITLE
  Using a reconstruction locking compression plate as external fixator in 
infected open clavicle fracture
AUTHOR NAMES
  Sirisreetreerux N.; Sa-ngasoongsong P.; Chanplakorn P.; Kulachote N.; Laohajaroensombat S.; Suphachatwong C.; Phiphobmongko V.; Wajanavisit W.
AUTHOR ADDRESSES
  (Sirisreetreerux N.; Sa-ngasoongsong P., chan3s@hotmail.com; Chanplakorn P.; 
Kulachote N.; Laohajaroensombat S.; Suphachatwong C.; Wajanavisit W.) 
Ramathibodi Hospital, Mahidol University, Thailand.
(Phiphobmongko V.) Department of Orthopaedic Surgery, Bhumibol Adulyadej 
Hospital, Royal Thai Air Force, Thailand.
CORRESPONDENCE ADDRESS
  P. Sa-ngasoongsong, Department of Orthopaedics, Ramathibodi Hospital, 
Mahidol University, 270, Rama VI Road, Ratchathewi, Bangkok, 10400, 
Thailand. Email: chan3s@hotmail.com
AiP/IP ENTRY DATE
  2013-06-18
FULL RECORD ENTRY DATE
  2013-06-28
SOURCE
  Orthopedic Reviews (2013) 5:2 (52-55). Date of Publication: 2013
VOLUME
  5
ISSUE
  2
FIRST PAGE
  52
LAST PAGE
  55
DATE OF PUBLICATION
  2013
ISSN
  2035-8237
  2035-8164 (electronic)
BOOK PUBLISHER
  Page Press Publication, via Giuseppe Belli, Pavia, Italy.
ABSTRACT
  Open clavicle fracture is an uncommon injury mostly caused by severe direct 
trauma. It is often associated with multiple organ injuries. Generally, 
surgical intervention with debridement and fracture repair is always 
indicated in order to prevent infection, non-union, and malalignment. In 
situations of bony exposure and significant contamination concomitant with 
severe soft tissue damage, the external fixation is the treatment of choice 
because of the possibility it offers of providing stable fixation with 
minimal local tissue damage resulting in excellent union rates and better 
soft tissue outcome. Nevertheless, traditional external fixation encountered 
some potential problems as its bulkiness and sharp edges caused discomfort 
to the patient. In this study, we present an interesting case of a 
polytraumatized patient with a gunshot injury with complex open clavicle 
fracture that was successfully treated with external fixation using 
reconstruction with a locking compression plate as definitive treatment. © 
N. Sirisreetreerax et al., 2013.
EMTREE DRUG INDEX TERMS
  povidone iodine (topical drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  clavicle fracture (diagnosis, surgery); compression plate; reconstruction locking compression plate; 
EMTREE MEDICAL INDEX TERMS
  Acinetobacter baumannii; adult; article; bone infection; case report; debridement; fracture external fixation; fracture healing; gunshot injury; human; internal fixator; male; range of motion; respiratory distress; soft tissue inflammation; spinal cord injury; tracheostomy; X ray; 
DRUG TRADE NAMES
  betadine
CAS REGISTRY NUMBERS
  povidone iodine (25655-41-8)
EMBASE CLASSIFICATIONS
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013366210
PUI
  L369082295
DOI
  10.4081/or.2013.e11
FULL TEXT LINK
  http://dx.doi.org/10.4081/or.2013.e11
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20358237&id=doi:10.4081%2For.2013.e11&atitle=Using+a+reconstruction+locking+compression+plate+as+external+fixator+in+infected+open+clavicle+fracture&stitle=Orthop.+Rev.&title=Orthopedic+Reviews&volume=5&issue=2&spage=52&epage=55&aulast=Sirisreetreerux&aufirst=Norachart&auinit=N.&aufull=Sirisreetreerux+N.&coden=&isbn=&pages=52-55&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 516
TITLE
  Video laryngoscopy added fiberoptic intubation in a patient with difficult 
airway
AUTHOR NAMES
  Gupta N.; Pandia M.P.; Prabhakar H.; Chauhan M.
AUTHOR ADDRESSES
  (Gupta N.; Pandia M.P., pandiamihir@gmail.com; Prabhakar H.; Chauhan M.) 
Department of Neuroanaesthesia, All India Institute of Medical Sciences, New 
Delhi - 110 029, India.
CORRESPONDENCE ADDRESS
  M.P. Pandia, Department of Neuroanaesthesia, All India Institute of Medical 
Sciences, New Delhi - 110 029, India. Email: pandiamihir@gmail.com
AiP/IP ENTRY DATE
  2013-06-11
FULL RECORD ENTRY DATE
  2013-06-20
SOURCE
  Journal of Anaesthesiology Clinical Pharmacology (2013) 29:2 (283-284). Date 
of Publication: 2013
VOLUME
  29
ISSUE
  2
FIRST PAGE
  283
LAST PAGE
  284
DATE OF PUBLICATION
  2013
ISSN
  0970-9185
  2231-2730 (electronic)
BOOK PUBLISHER
  Medknow Publications and Media Pvt. Ltd, B9, Kanara Business Centre, off 
Link Road, Ghatkopar (E), Mumbai, India.
EMTREE DRUG INDEX TERMS
  fentanyl; propofol; rocuronium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; laryngoscopy; video laryngoscopy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; atlantoaxial dislocation (diagnosis); bone plate; bone screw; bone transplantation; case report; cervical spine; child; compression fracture (diagnosis); endotracheal tube; epiglottis; fiberoscope; human; intensive care unit; intramedullary nailing; kyphosis; letter; lung auscultation; male; nuclear magnetic resonance imaging; oxygen saturation; positive end expiratory pressure; preoperative evaluation; school child; spinal cord compression; spine fracture; spine radiography; spine stabilization; tracheostomy; tracheostomy tube; wound healing; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  propofol (2078-54-8)
  rocuronium (119302-91-9)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013349378
PUI
  L369037782
DOI
  10.4103/0970-9185.111745
FULL TEXT LINK
  http://dx.doi.org/10.4103/0970-9185.111745
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09709185&id=doi:10.4103%2F0970-9185.111745&atitle=Video+laryngoscopy+added+fiberoptic+intubation+in+a+patient+with+difficult+airway&stitle=J.+Anaesthesiol.+Clin.+Pharmacol.&title=Journal+of+Anaesthesiology+Clinical+Pharmacology&volume=29&issue=2&spage=283&epage=284&aulast=Gupta&aufirst=Nidhi&auinit=N.&aufull=Gupta+N.&coden=JAPHF&isbn=&pages=283-284&date=2013&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 517
TITLE
  Transoral endoscopic odontoidectomy to decompress the cervicomedullary 
junction
AUTHOR NAMES
  Zhang Q.; Kong F.; Yan B.; Guo H.; Li M.; Chen G.; Ling F.
AUTHOR ADDRESSES
  (Zhang Q., zhangqiuhang@yahoo.com.cn; Kong F.; Guo H.; Li M.; Chen G.) Skull 
Base Surgery Center, Capital Medical University, Xuanwu Hospital, No. 45, 
Changchunjie St, Xicheng District, Beijing, China.
(Yan B.) Departments of Otolaryngology Head and Neck Surgery, United States.
(Ling F.) Department of Neurological Surgery, Capital Medical University 
Xuanwu Hospital, Beijing, China.
CORRESPONDENCE ADDRESS
  Q. Zhang, Skull Base Surgery Center, Capital Medical University, Xuanwu 
Hospital, No. 45, Changchunjie St, Xicheng District, Beijing, China. Email: 
zhangqiuhang@yahoo.com.cn
AiP/IP ENTRY DATE
  2013-07-19
FULL RECORD ENTRY DATE
  2013-07-23
SOURCE
  Spine (2013) 38:14 (E901-E906). Date of Publication: 15 Jun 2013
VOLUME
  38
ISSUE
  14
DATE OF PUBLICATION
  15 Jun 2013
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Study Design. Clinical study. Objective. To investigate the feasibility of 
the transoral endoscopic odontoidectomy without occipitocervical fusion. 
Summary of Background Data. Endoscopic transnasal resection of the odontoid 
process is less invasive than the conventional transoral odontoidectomy. 
However, the endonasal approach has a much longer working distance compared 
with the transoral approach to the craniovertebral junction and usually the 
endonasal approach needs a previous occipitocervical posterior fusion. 
Methods. From July 2007 to June 2010, 5 patients (3 males and 2 females, age 
range, 25-41 yr) with irreducible cervicomedullary junction compression were 
subjected to endoscopic transoral odontoidectomy without occipitocervical 
posterior fi xation and bone fusion. Results. A purely endoscopic transoral 
odontoidectomy for decompression of the cervicomedullary junction without 
the occipitocervical fusion was achieved successfully in 5 patients. None of 
the patients underwent tracheotomy and postoperative gastrostomy tube 
placement. The patients were started on liquids on the third postoperative 
day and advanced to a regular diet on the fourth postoperative day. There 
was no postoperative velopharyngeal insuffi ciency, cerebrospinal fluid 
leakage, regional infection, or meningitis. The patients were discharged in 
10 to 12 days after the surgery. There were no evidence of instability at 
the craniovertebral junction at 12 to 47 months of follow-up and remarkable 
improvement in neurological function was observed in each patient. 
Conclusion. The endoscopic transoral approach may be a more direct route to 
C1 and the odontoid than the endoscopic endonasal approach. This approach 
allows complete resection odontoid to decompress the cervicomedullary 
junction without increasing the risk of complications such as wound 
infection, meningitis, and velopharyngeal insuffi ciency. Usually, the 
occipitocervical posterior fusion and tracheotomy is less necessary in this 
approach. Copyright © 2013 Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervicomedullary junction; endoscopic surgery; spinal cord; spinal cord decompression; transoral endoscopic odontoidectomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; Babinski reflex; clinical article; computer assisted tomography; diet; feasibility study; female; fluid intake; follow up; functional status; general condition improvement; Hoffmann reflex; human; male; neck pain; nuclear magnetic resonance imaging; priority journal; spinal cord compression (diagnosis, surgery); surgical patient; syringomyelia (diagnosis); treatment outcome; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013436734
MEDLINE PMID
  23558440 (http://www.ncbi.nlm.nih.gov/pubmed/23558440)
PUI
  L369300063
DOI
  10.1097/BRS.0b013e3182941735
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e3182941735
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e3182941735&atitle=Transoral+endoscopic+odontoidectomy+to+decompress+the+cervicomedullary+junction&stitle=Spine&title=Spine&volume=38&issue=14&spage=&epage=&aulast=Zhang&aufirst=Qiuhang&auinit=Q.&aufull=Zhang+Q.&coden=SPIND&isbn=&pages=-&date=2013&auinit1=Q&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 518
TITLE
  Severe spinal cord injury in craniocervical dislocation. Case-based update
AUTHOR NAMES
  Martínez-Lage J.F.; Alarcón F.; Alfaro R.; Gilabert A.; Reyes S.B.; Almagro M.-J.; López-Guerrero A.L.
AUTHOR ADDRESSES
  (Martínez-Lage J.F., juanf.martinezlage@cablemurcia.com; Almagro M.-J.; 
López-Guerrero A.L.) Unit of Pediatric Neurosurgery, Regional Service of 
Neurosurgery, Virgen de la Arrixaca University Children's Hospital, 30120 El 
Palmar, Murcia, Spain.
(Alarcón F.; Alfaro R.) Unit of Spine Neurosurgery, Regional Service of 
Neurosurgery, Virgen de la Arrixaca University Hospital, 30120 El Palmar, 
Murcia, Spain.
(Gilabert A.) Section of Pediatric Radiology, Virgen de la Arrixaca 
University Children's Hospital, 30120 El Palmar, Murcia, Spain.
(Reyes S.B.) Pediatric Intensive Care Unit, Virgen de la Arrixaca University 
Children's Hospital, 30120 El Palmar, Murcia, Spain.
CORRESPONDENCE ADDRESS
  J.F. Martínez-Lage, Unit of Pediatric Neurosurgery, Regional Service of 
Neurosurgery, Virgen de la Arrixaca University Children's Hospital, 30120 El 
Palmar, Murcia, Spain. Email: juanf.martinezlage@cablemurcia.com
AiP/IP ENTRY DATE
  2012-09-12
FULL RECORD ENTRY DATE
  2013-06-13
SOURCE
  Child's Nervous System (2013) 29:2 (187-194). Date of Publication: 2013
VOLUME
  29
ISSUE
  2
FIRST PAGE
  187
LAST PAGE
  194
DATE OF PUBLICATION
  2013
ISSN
  0256-7040
  1433-0350 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Background: Craniocervical distraction injuries, including atlanto-axial 
dislocation (AAD) and atlanto-ocipital dislocation (AOD), are often 
associated with severe spinal cord involvement with high morbidity and 
mortality rates. Many patients with these injuries die at the accident 
scene, but advances in emergency resuscitation and transport permit that 
many patients arrive alive to hospitals. Discussion: Children with 
craniocervical distraction injuries usually present with a severe 
cranioencephalic traumatism that is the most relevant lesion at admission. 
After resuscitation and hemodynamic stabilization, the spinal cord damage 
appears as the main lesion. Apnea and quadriparesis, or quadriplegia, are 
usually present at the onset. Early diagnosis and management perhaps 
decrease life-threatening manifestations of the spinal lesion. But even so, 
the primary spinal cord insult is often irreversible and precludes obtaining 
a satisfactory functional outcome. Patients and methods: We report the 
findings of four children with craniocervical distraction injuries (AOD and 
AAD) who presented with severe spinal cord damage. All patients were 
admitted with respiratory distress or apnea together with significant brain 
injuries. The medical records pertaining to these patients are summarized in 
regard to clinical features, management, and outcome. Conclusions: In spite 
of timely and aggressive management, craniocervical injuries with spinal 
cord involvement continue to have a dismal prognosis. Outcome is closely 
related to the severity of the initial brain and spinal cord damage and is 
nearly always fatal in cases of complete spinal cord transection. Priority 
should be given to life-threatening complications. Ethic issues on 
indications for surgery deserve a detailed discussion with the children's 
parents. © 2012 Springer-Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial dislocation (surgery, therapy); atlantoocipital dislocation (surgery, therapy); cervical spine dislocation (surgery, therapy); childhood injury (surgery, therapy); spinal cord injury (surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication); adolescent; anemia (therapy); apnea (complication); article; blood transfusion; brain contusion; brain edema (complication); brain injury; case report; cerebellum infarction; cervical collar; child; coma; computer assisted tomography; congenital disorder; disease severity; ego development; endotracheal intubation; face edema; female; follow up; fracture external fixation; fracture immobilization; Glasgow coma scale; hemodynamics; hospital admission; human; hypercapnia; hypoxemia; infant; intensive care unit; intracranial pressure monitoring; male; mandible fracture; metabolic acidosis; mortality; neuroimaging; nuclear magnetic resonance imaging; osteosynthesis; oxygen desaturation; pneumonia; preschool child; priority journal; prognosis; quadriplegia (complication); respiratory distress; resuscitation; school child; septic shock; skull base; somatosensory evoked potential; spinal cord lesion; spinal cord transsection; spine fusion; spine injury; subarachnoid hemorrhage; survival; tracheostomy; traffic accident; traumatic brain injury; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013348529
MEDLINE PMID
  22961360 (http://www.ncbi.nlm.nih.gov/pubmed/22961360)
PUI
  L52200320
DOI
  10.1007/s00381-012-1915-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-012-1915-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-012-1915-5&atitle=Severe+spinal+cord+injury+in+craniocervical+dislocation.+Case-based+update&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=29&issue=2&spage=187&epage=194&aulast=Mart%C3%ADnez-Lage&aufirst=Juan+F.&auinit=J.F.&aufull=Mart%C3%ADnez-Lage+J.F.&coden=CNSYE&isbn=&pages=187-194&date=2013&auinit1=J&auinitm=F
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 519
TITLE
  The experience of parents regarding ventilatory support with tracheotomy 
decision-making for their child with type 1 spinal muscular atrophy
AUTHOR NAMES
  Rul B.; Carnevale F.; Estournet B.; Quijano-Roy S.; Desguerre I.; Hervé C.
AUTHOR ADDRESSES
  (Rul B.; Estournet B.; Quijano-Roy S.) Pôle Pédiatrie, Hôpital Raymond 
Poincaré, Garches, France.
(Rul B.; Hervé C.) Laboratoire d'Ethique Médicale et Médecine Légale, 
Université Paris-Descartes, Paris, France.
(Carnevale F.) McGill University, Montreal, Canada.
(Carnevale F.) Montreal Children's Hospital, Montreal, Canada.
(Estournet B.; Quijano-Roy S.) Faculté de Médecine, Université de Versailles 
St-Quentin-en-Yvelines, Montigny-le-Bretonneux, Paris, France.
(Desguerre I.) Service de Neurologie Pédiatrie, Hôpital Necker-Enfants 
Malades, Paris, France.
CORRESPONDENCE ADDRESS
  B. Rul, Pôle Pédiatrie, Hôpital Raymond Poincaré, Garches, France.
FULL RECORD ENTRY DATE
  2014-05-12
SOURCE
  Intensive Care Medicine (2013) 39 SUPPL. 1 (S12). Date of Publication: June 
2013
VOLUME
  39
FIRST PAGE
  S12
DATE OF PUBLICATION
  June 2013
CONFERENCE NAME
  24th Annual Meeting of the European Society of Paediatric and Neonatal 
Intensive Care, ESPNIC 2013
CONFERENCE LOCATION
  Rotterdam, Netherlands
CONFERENCE DATE
  2013-06-12 to 2013-06-15
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background: Type 1 Spinal Muscular Atrophy (SMA) (subdivided in France as 
Type 1 true or bis), is a neuromuscular disorder that progressively 
paralyzes the child, compromising the child's prognosis as respiratory 
muscles are affected. The tracheotomy may help prevent death, but entails 
ethical questions given the severity of the motor disability that will 
follow. Regardless of whether or not health care professionals (HCP) agree 
with performing a tracheostomy for this population, they cannot make this 
decision alone-parents must be included in the decisional process. 
Considering that HCP teams in France are tending to favor tracheostomy for 
Type 1 bis SMA, a study was conducted with parents of these children who had 
been tracheotomised, to better understand how they experienced this 
decision. Method: Interpretive phenomenological interviews of 13 parents of 
7 tracheostomized children with SMA Type 1 bis, recruited from two 
children's hospitals in France. Results: Initially, parents do not want 
their children to be tracheostomized. They gradually come to accept the 
proposed tracheostomy because of a profound feeling of powerlessness 
regarding the illness and their trust toward the HCP. This decision marked 
an important turning point, which varied across parents in terms of the 
difficulties they had to overcome. Conclusion: The pediatric neurologist, 
the child's referring physician, is the principal interlocutor for such a 
tracheotomy decision. This decision relies on the treatment discussions that 
the physician has with the parents.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child; decision making; human; newborn intensive care; parent; society; spinal muscular atrophy; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  breathing muscle; death; diseases; France; health care personnel; interview; motor dysfunction; neurologist; neuromuscular disease; pediatric hospital; physician; population; powerlessness; prognosis; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71439817
DOI
  10.1007/s00134-013-2950-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-013-2950-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-013-2950-8&atitle=The+experience+of+parents+regarding+ventilatory+support+with+tracheotomy+decision-making+for+their+child+with+type+1+spinal+muscular+atrophy&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=39&issue=&spage=S12&epage=&aulast=Rul&aufirst=B.&auinit=B.&aufull=Rul+B.&coden=&isbn=&pages=S12-&date=2013&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 520
TITLE
  An autopsied case of adult-type Alexander disease with S393R mutation in the 
GFAP gene
AUTHOR NAMES
  Iwasaki Y.; Mori K.; Ito M.; Saito Y.; Tatsumi S.; Mimuro M.; Mizuta I.; Yoshida T.; Nakagawa M.; Yoshida M.
AUTHOR ADDRESSES
  (Iwasaki Y.; Tatsumi S.; Mimuro M.; Yoshida M.) Dept. of Neuropathol., Inst. 
for Med. Sci. of Aging, Aichi Med. Univ, Japan.
(Mori K.; Ito M.) Dept. of Neurol., Oyamada Memorial Spa Hosp, Japan.
(Saito Y.) Dept. of Neurol., Higashi Nagoya National Hosp, Japan.
(Mizuta I.; Yoshida T.; Nakagawa M.) Dept. of Neurol., Kyoto Prefectural 
Univ. of Med, Japan.
CORRESPONDENCE ADDRESS
  Y. Iwasaki, Dept. of Neuropathol., Inst. for Med. Sci. of Aging, Aichi Med. 
Univ, Japan.
FULL RECORD ENTRY DATE
  2013-09-27
SOURCE
  Neuropathology (2013) 33:3 (378). Date of Publication: June 2013
VOLUME
  33
ISSUE
  3
FIRST PAGE
  378
DATE OF PUBLICATION
  June 2013
CONFERENCE NAME
  54th Annual Meeting of the Japanese Society of Neuropathology
CONFERENCE LOCATION
  Tokyo, Japan
CONFERENCE DATE
  2013-04-24 to 2013-04-26
ISSN
  0919-6544
BOOK PUBLISHER
  Blackwell Publishing
ABSTRACT
  A 50-year-old Japanese man with no remarkable family history noticed 
diplopia. Gait disturbance, muscle weakness and dysuria gradually 
progressed. Neurological examination 6 years post onset revealed eye 
movement disorders with nystagmus, sensory disturbance and orthostatic 
hypotension. Tongue atrophy with fasciculation was observed. Deep tendon 
reflex was brisk with positive Babinski sign. MRI showed severe atrophy of 
the medulla oblongata to cervical cord (tadpole appearance). He progressed 
to tetraplegia, and tracheostomy and gastrostomy were performed after 
dysphagia developed. Stable state continued for several years, and he died 
due to respiratory failure 11 years after onset. The brain weighed 1380 g. 
Numerous Rosenthal fibers were observed in the medulla oblongata to spinal 
cord. Myelin loss with relatively preserved axons was extensively observed 
from the middle of the pons to the spinal cord. A few Rosenthal fibers were 
also observed in the cerebral white matter, basal ganglia and cerebellum, 
particularly in the ventricular subependyma. Clinicopathological diagnosis 
was adult-onset bulbospinal-type Alexander disease. GFAP gene analysis 
revealed a novel mutation of S393R.
EMTREE DRUG INDEX TERMS
  myelin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult; Alexander disease; gene; Japanese (people); mutation; neuropathology; society; 
EMTREE MEDICAL INDEX TERMS
  atrophy; Babinski reflex; basal ganglion; brain; cerebellum; cervical spinal cord; diagnosis; diplopia; dysphagia; dysuria; eye movement disorder; family history; fasciculation; fiber; gait; gastrostomy; human; male; medulla oblongata; muscle weakness; nerve fiber; neurologic examination; nuclear magnetic resonance imaging; nystagmus; orthostatic hypotension; pons; quadriplegia; respiratory failure; spinal cord; subventricular zone; tadpole; tendon reflex; tongue; tracheostomy; white matter; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71171114
DOI
  10.1111/neup.12034
FULL TEXT LINK
  http://dx.doi.org/10.1111/neup.12034
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:10.1111%2Fneup.12034&atitle=An+autopsied+case+of+adult-type+Alexander+disease+with+S393R+mutation+in+the+GFAP+gene&stitle=Neuropathology&title=Neuropathology&volume=33&issue=3&spage=378&epage=&aulast=Iwasaki&aufirst=Y.&auinit=Y.&aufull=Iwasaki+Y.&coden=&isbn=&pages=378-&date=2013&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 521
TITLE
  Eighteen years with spinal muscular atrophy (SMA) type 1
AUTHOR NAMES
  Valencia B.; Bach J.R.
AUTHOR ADDRESSES
  (Valencia B.) Unidad Medico-Quirurgica de Enfermedades Respiratorias, 
Hospital Virgen Del Rocio, Sevilla, Spain.
(Bach J.R., bachjr@umdnj.edu) Department of Physical Medicine and 
Rehabilitation, University of Medicine and Dentistry of New Jersey 
(UMDNJ)-New Jersey Medical School, Newark, NJ, United States.
CORRESPONDENCE ADDRESS
  J. R. Bach, Department of Physical Medicine and Rehabilitation, University 
Hospital B-261, 150 Bergen Street, Newark, NJ 07103, United States. Email: 
bachjr@umdnj.edu
AiP/IP ENTRY DATE
  2013-05-22
FULL RECORD ENTRY DATE
  2013-05-27
SOURCE
  Tanaffos (2013) 12:1 (70-73). Date of Publication: 2013
VOLUME
  12
ISSUE
  1
FIRST PAGE
  70
LAST PAGE
  73
DATE OF PUBLICATION
  2013
ISSN
  1735-0344
BOOK PUBLISHER
  Shaheed Beheshti Uni. of Medical Sci. and Health Services, P.O. Box 
19575/154, Tehran, Iran.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  adult; article; assisted ventilation; bi level positive airway pressure; case report; extubation; female; human; mechanically assisted coughing; medical history; respiratory care; tracheotomy; upper respiratory tract infection; vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Human Genetics (22)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013309343
PUI
  L368920482
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17350344&id=doi:&atitle=Eighteen+years+with+spinal+muscular+atrophy+%28SMA%29+type+1&stitle=Tanaffos&title=Tanaffos&volume=12&issue=1&spage=70&epage=73&aulast=Valencia&aufirst=Borja&auinit=B.&aufull=Valencia+B.&coden=&isbn=&pages=70-73&date=2013&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 522
TITLE
  Pulmonary issues in patients with chronic neuromuscular disease
AUTHOR NAMES
  Benditt J.O.; Boitano L.J.
AUTHOR ADDRESSES
  (Benditt J.O., benditt@uw.edu; Boitano L.J.) University of Washington School 
of Medicine, Seattle, WA, United States.
CORRESPONDENCE ADDRESS
  J.O. Benditt, Pulmonary and Critical Care Medicine, University of Washington 
Medical Center, Box 356522, Seattle, WA 98195-6522, United States. Email: 
benditt@uw.edu
AiP/IP ENTRY DATE
  2013-05-27
FULL RECORD ENTRY DATE
  2013-05-29
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2013) 187:10 
(1046-1055). Date of Publication: 15 May 2013
VOLUME
  187
ISSUE
  10
FIRST PAGE
  1046
LAST PAGE
  1055
DATE OF PUBLICATION
  15 May 2013
ISSN
  1073-449X
  1535-4970 (electronic)
BOOK PUBLISHER
  American Thoracic Society, 61 Broadway 4th Floor, New York, United States.
ABSTRACT
  Patients with chronic neuromuscular diseases such as spinal cord injury, 
amyotrophic lateral sclerosis, and muscular dystrophies experience 
respiratory complications that are cared for by the respiratory 
practitioner. An organized anatomical approach for evaluation and treatment 
is helpful to provide appropriate clinical care. Effective noninvasive 
strategies for management of hypoventilation, sleep-disordered breathing, 
and cough insufficiency are available for these patients. Copyright © 2013 
by the American Thoracic Society.
EMTREE DRUG INDEX TERMS
  dystrophin (endogenous compound); glycoprotein (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chronic disease; neuromuscular disease; respiratory tract disease (complication); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; atelectasis; autonomic dysfunction; breathing muscle; central nervous system disease; coughing; dermatomyositis; diaphragm paralysis; disease association; human; hypoventilation; interstitial lung disease; lung alveolus hypoventilation; motoneuron; multiple sclerosis; muscle weakness; muscular dystrophy; myasthenia gravis; myopathy; myositis; myotonic dystrophy; noninvasive ventilation; pneumonia; poliomyelitis; priority journal; respiratory failure; review; sleep disordered breathing; spinal cord disease; spinal cord injury; syringomyelia; thorax radiography; tracheostomy; upper respiratory tract obstruction; 
CAS REGISTRY NUMBERS
  dystrophin (116978-02-0)
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013316940
MEDLINE PMID
  23590262 (http://www.ncbi.nlm.nih.gov/pubmed/23590262)
PUI
  L368940175
DOI
  10.1164/rccm.201210-1804CI
FULL TEXT LINK
  http://dx.doi.org/10.1164/rccm.201210-1804CI
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:10.1164%2Frccm.201210-1804CI&atitle=Pulmonary+issues+in+patients+with+chronic+neuromuscular+disease&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=187&issue=10&spage=1046&epage=1055&aulast=Benditt&aufirst=Joshua+O.&auinit=J.O.&aufull=Benditt+J.O.&coden=AJCME&isbn=&pages=1046-1055&date=2013&auinit1=J&auinitm=O
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 523
TITLE
  Conservative management of esophageal perforation after a fall
AUTHOR NAMES
  Delos Reyes A.P.; Clancy C.; Lach J.; Olorunto W.A.; Williams M.
AUTHOR ADDRESSES
  (Delos Reyes A.P., arthur.reyes@utoledo.edu; Clancy C.; Lach J.; Olorunto 
W.A.) University of Toledo Medical Center, 3000 Arlington Ave, Toledo, OH 
43614, United States.
(Williams M.) Division of Trauma, Critical Care and Acute Care Surgery, 
University of Toledo College of Medicine, 3000 Arlington Ave, Toledo, OH 
43614, United States.
CORRESPONDENCE ADDRESS
  A.P. Delos Reyes, University of Toledo Medical Center, 3000 Arlington Ave, 
Toledo, OH 43614, United States. Email: arthur.reyes@utoledo.edu
AiP/IP ENTRY DATE
  2013-05-08
FULL RECORD ENTRY DATE
  2013-05-13
SOURCE
  International Journal of Surgery Case Reports (2013) 4:6 (550-553). Date of 
Publication: 2013
VOLUME
  4
ISSUE
  6
FIRST PAGE
  550
LAST PAGE
  553
DATE OF PUBLICATION
  2013
ISSN
  2210-2612 (electronic)
BOOK PUBLISHER
  Elsevier Ltd, Langford Lane, Kidlington, Oxford, United Kingdom.
ABSTRACT
  INTRODUCTION: Esophageal perforation in the setting of blunt trauma is rare, 
and diagnosis can be difficult due to atypical signs and symptoms 
accompanied by distracting injury. PRESENTATION OF CASE: We present a case 
of esophageal perforation resulting from a fall from height. Unexplained air 
in the soft tissues planes posterior to the esophagus as well as 
subcutaneous emphysema in the absence of a pneumothorax on CT aroused 
clinical suspicions of an injury to the aerodigestive tract. The patient 
suffered multiple injuries including bilateral first rib fractures, C6 
lamina fractures, C4-C6 spinous process fractures, a C7 right transverse 
process fracture with associated ligamentous injury and cord contusion, 
multiple comminuted nasal bone fractures, and a right verterbral artery 
dissection. Esophageal injury was localized using a gastrograffin esophagram 
to the cervical esophagus and was most likely secondary to cervical spine 
fractures. Because there were no clinical signs of sepsis and the esophagram 
demonstrated a contained rupture, the patient was thought to be a good 
candidate for a trial of conservative management consisting of broad 
spectrum intravenous antibiotics, oral care with chlorhexadine gluconate, 
NPO, and total parenteral nutrition. No cervical spine fixation or procedure 
was performed during this trial of conservative management. The patient was 
received another gastrograffin esophagram on hospital day 14 and 
demonstrated no evidence of contrast extravasation. DISCUSSION: Early 
diagnosis and control of the infectious source are the cornerstones to 
successful management of esophageal perforation from all etiologies. 
Traditionally, esophageal perforation relied on a high index of clinical 
suspicion for early diagnosis, but the use of CT scan for has proved to be 
highly effective in diagnosing esophageal perforation especially in patients 
with atypical presentations. While aggressive surgical infection control is 
paramount in the majority of esophageal perforations, a select subset of 
patients can be successfully managed non-operatively. CONCLUSION: In the 
setting of blunt trauma, esophageal perforation is rare and is associated 
with a high morbidity. In select patients who do not show any clinical signs 
of sepsis, contained perforations can heal with non-operative management 
consisting of broad spectrum antibiotics, strict oral hygiene, NPO, and 
total parenteral nutrition. © 2013 Surgical Associates Ltd.
EMTREE DRUG INDEX TERMS
  chlorhexidine gluconate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  conservative treatment; esophagus perforation; falling; 
EMTREE MEDICAL INDEX TERMS
  adult; antibiotic therapy; artery dissection; article; bradycardia; breathing rate; case report; cervical spine fracture; comminuted fracture; computed tomographic angiography; computer assisted tomography; contrast medium extravasation; contusion; early diagnosis; electrocardiography; esophagus injury; female; hand grip; heart palpitation; heart rate; human; intensive care; motor dysfunction; mouth hygiene; multiple trauma; nose fracture; nose septum; nuclear magnetic resonance imaging; priority journal; respiratory failure; resuscitation; rib fracture; sepsis; sinus bradycardia; spine stabilization; subcutaneous emphysema; thorax radiography; total parenteral nutrition; tracheostomy; 
CAS REGISTRY NUMBERS
  chlorhexidine gluconate (18472-51-0)
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013272735
PUI
  L368817900
DOI
  10.1016/j.ijscr.2013.02.009
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijscr.2013.02.009
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=22102612&id=doi:10.1016%2Fj.ijscr.2013.02.009&atitle=Conservative+management+of+esophageal+perforation+after+a+fall&stitle=Int.+J.+Surg.+Case+Rep.&title=International+Journal+of+Surgery+Case+Reports&volume=4&issue=6&spage=550&epage=553&aulast=Delos+Reyes&aufirst=Arthur+P.&auinit=A.P.&aufull=Delos+Reyes+A.P.&coden=&isbn=&pages=550-553&date=2013&auinit1=A&auinitm=P
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 524
TITLE
  Dysphagia in acute tetraplegia: Diagnosis, incidence, and associated factors
AUTHOR NAMES
  Shem K.; Castillo K.; Wong S.L.; Chang J.
AUTHOR ADDRESSES
  (Shem K.; Castillo K.; Wong S.L.; Chang J.) Santa Clara Valley Medical 
Center, San Jose, United States.
CORRESPONDENCE ADDRESS
  K. Shem, Santa Clara Valley Medical Center, San Jose, United States.
FULL RECORD ENTRY DATE
  2013-10-11
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2013) 19:1 (21). Date of 
Publication: May 2013
VOLUME
  19
ISSUE
  1
FIRST PAGE
  21
DATE OF PUBLICATION
  May 2013
CONFERENCE NAME
  40th Anniversary Annual Scientific Meeting of the American Spinal Injury 
Association, ASIA 2013
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2013-05-06 to 2013-05-08
ISSN
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc.
ABSTRACT
  Objective: Identify the incidence and risk factors for dysphagia after 
spinal cord injury (SCI) and determine the accuracy of bedside swallow 
evaluation (BSE) as a diagnostic tool. Design: Prospective study. 
Participants/Methods: Individuals with SCI admitted to an SCI unit underwent 
a BSE as soon as they were able to participate in BSE, followed by a 
videofluoroscopy swallow study (VFSS) within 72 hours of the BSE. Subjects 
were categorized as having dysphagia if they had positive findings in either 
BSE or VFSS. Results: Seventy-six patients (13 female and 63 male) were 
enrolled. The average age of the subjects was 41.9 years (SD =17.5). 
Fifty-six (74%) had high cervical tetraplegia (C4 or higher). Dysphagia was 
present in 23 subjects (30.3%). The associations between dysphagia and the 
presence of tracheostomy ( = .014), ventilator use (P = .040), pneumonia (P 
= .001), and nasogastric tube (P = .012) proved to be statistically 
significant. Although not statistically significant, a trend was noted 
between dysphagia and age (P = .056). Positive findings on BSE were 
different from the findings on VFSS only in 3 cases. Sensitivity of BSE was 
100% and specificity of BSE was 84% when VFSS was considered as gold 
standard for diagnosing dysphagia. Excluding those subjects who still had 
dysphagia on discharge, average days from initial diagnosis of dysphagia 
based on BSE to the resolution of dysphagia was 14.1 days (SD = 9.5 days). 
Conclusion: Nasogastric tube, tracheostomy, and ventilator use are 
significant risk factors for dysphagia after SCI. When present, dysphagia 
resolved within 15 days of diagnosis of dysphagia.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diagnosis; dysphagia; quadriplegia; spine injury; 
EMTREE MEDICAL INDEX TERMS
  female; gold standard; human; male; nasogastric tube; patient; pneumonia; prospective study; risk factor; spinal cord injury; swallow (bird); tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71184277
DOI
  10.1310/sci19S1-21
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci19S1-21
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci19S1-21&atitle=Dysphagia+in+acute+tetraplegia%3A+Diagnosis%2C+incidence%2C+and+associated+factors&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=19&issue=1&spage=21&epage=&aulast=Shem&aufirst=Kazuko&auinit=K.&aufull=Shem+K.&coden=&isbn=&pages=21-&date=2013&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 525
TITLE
  Laryngeal dislocation after ventral fusion of the cervical spine
AUTHOR NAMES
  Krauel J.; Winkler D.; Münscher A.; Tank S.
AUTHOR ADDRESSES
  (Krauel J.; Tank S., sascha.tank@gmx.de) Departments of Anesthesiology and 
Intensive Care, University Medical Center of Hamburg- Eppendorf, 
Martinistrasse 52, 20251 Hamburg, Germany.
(Winkler D.) Departments of Neurosurgery, University Medical Center of 
Hamburg- Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany.
(Münscher A.) Departments of Ears, Nose, Throat, University Medical Center 
of Hamburg- Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany.
CORRESPONDENCE ADDRESS
  S. Tank, Departments of Anesthesiology and Intensive Care, Hamburg- 
Eppendorf University Hospital, Martinistrasse 52, 20246 Hamburg, Germany. 
Email: sascha.tank@gmx.de
AiP/IP ENTRY DATE
  2013-08-06
FULL RECORD ENTRY DATE
  2013-08-14
SOURCE
  Indian Journal of Anaesthesia (2013) 57:3 (285-288). Date of Publication: 
May-June 2013
VOLUME
  57
ISSUE
  3
FIRST PAGE
  285
LAST PAGE
  288
DATE OF PUBLICATION
  May-June 2013
ISSN
  0019-5049
BOOK PUBLISHER
  Indian Society of Anaesthetists, Flat No 12/1A K Point, 68-BAPC Roy Road, 
Kolkata, India.
ABSTRACT
  We report on a 70-year-old patient who underwent ventral fusion of the 
cervical spine (C3/4 and C4/5) for spinal canal stenosis performed by the 
neurosurgery department. The patient suffered an exceedingly rare 
complication of the surgery - laryngeal dislocation. Had the deformed 
laryngeal structures been overlooked and the patient extubated as usual 
after surgery, reintubation would have been impossible due to the associated 
swelling, which might have had disastrous consequences. Leftward dislocation 
of the larynx became apparent post-operatively, but prior to extubation. 
Extubation was therefore postponed and a subsequent computed tomography (CT) 
scan revealed entrapment of laryngeal structures within the osteosynthesis. 
A trial of repositioning using microlaryngoscopy performed by otolaryngology 
(ears, nose and throat) specialists failed, making open surgical revision 
necessary. At surgery, the entrapped laryngeal tissue was successfully 
mobilised. Laryngeal oedema developed despite prompt repositioning; thus, 
necessitating tracheotomy and long-term ventilation. Laryngeal dislocation 
may be an unusual cause of post-operative neck swelling after anterior 
cervical spine surgery and should be considered in the differential 
diagnosis if surgical site haematoma and other causes have been ruled out. 
Imaging studies including CT of the neck may be needed before extubation to 
confirm the suspicion and should be promptly obtained to facilitate specific 
treatment.
EMTREE DRUG INDEX TERMS
  contrast medium; dexamethasone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  larynx disorder (complication, diagnosis, surgery); spine fusion; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; cervical spine; computer assisted tomography; consciousness level; discectomy; edema (drug therapy); extubation; human; hyoid bone; intubation; laryngoscopy; male; microlaryngoscopy; osteosynthesis; pleura effusion; postoperative complication; respiratory failure; sepsis; spine stabilization; swelling; tracheotomy; ventilator associated pneumonia; vertebral canal stenosis; 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
EMBASE CLASSIFICATIONS
  Surgery (9)
  Otorhinolaryngology (11)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013477140
PUI
  L369439715
DOI
  10.4103/0019-5049.115615
FULL TEXT LINK
  http://dx.doi.org/10.4103/0019-5049.115615
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00195049&id=doi:10.4103%2F0019-5049.115615&atitle=Laryngeal+dislocation+after+ventral+fusion+of+the+cervical+spine&stitle=Indian+J.+Anaesth.&title=Indian+Journal+of+Anaesthesia&volume=57&issue=3&spage=285&epage=288&aulast=Krauel&aufirst=Jenny&auinit=J.&aufull=Krauel+J.&coden=&isbn=&pages=285-288&date=2013&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 526
TITLE
  Analysis of the risk factors for early death in acute severe traumatic 
cervical spinal cord injury
AUTHOR NAMES
  Leng Y.-X.; Nie C.-Y.; Yao Z.-Y.; Zhu X.
AUTHOR ADDRESSES
  (Leng Y.-X.; Nie C.-Y.; Yao Z.-Y.; Zhu X., xizhuccm@163.com) Department of 
Critical Care Medicine, Peking University Third Hospital, Beijing 100191, 
China.
CORRESPONDENCE ADDRESS
  X. Zhu, Department of Critical Care Medicine, Peking University Third 
Hospital, Beijing 100191, China. Email: xizhuccm@163.com
FULL RECORD ENTRY DATE
  2013-11-21
SOURCE
  Chinese Critical Care Medicine (2013) 25:5 (294-297). Date of Publication: 
May 2013
VOLUME
  25
ISSUE
  5
FIRST PAGE
  294
LAST PAGE
  297
DATE OF PUBLICATION
  May 2013
ISSN
  1003-0603
BOOK PUBLISHER
  Heilongjiang Institute of Science and Technology Information, 74 Yinhnag St, 
Nangang-qu, Harbin, China.
ABSTRACT
  Objective: To survey the risk factors for early death of patients with acute 
severe traumatic cervical spinal cord injury. Methods: A retrospective 
analysis of data of consecutive patients with acute severe traumatic 
cervical spinal cord injury admitted from January 1st 1994 to October 1st 
2012 were made. The patients died within 30 days or not were allocated for 
death group or survival group. The risk factors for early death were 
analyzed through univariate analysis and logistic analysis. Results: Among 
1093 patients with acute traumatic cervical spinal cord injury, 352 patients 
with severe injury were included, and the early death rate was 14.49% 
(51/352). The leading causes of spinal cord injury were vehicle accidents 
(153 cases) and falls (117 cases). The main causes of early death were 
respiratory failure (16 cases), multiple organ failure (MOF, 14 cases) and 
gastrointestinal bleeding (11 cases). Combining the results of univariate 
and logistic analysis, it was found that high acute physiology and chronic 
health evaluation II (APACHE II) score [>15, odds ratio (OR) = 11.595, 
P=0.000], high damage level (OR=3.519, P=0.032), hyponatremia (OR=6.316, 
P=0.000), neurogenic shock (OR=6.209, P=0.000), pulmonary infection 
(OR=14.627, P=0.000) and tracheostomy (OR=8.983, P=0.000) were risk factors 
for early death of patients with acute severe traumatic cervical spinal cord 
injury, however, the impact of gender, age, surgery, fracture and 
dislocation, high central fever, and administration of steroids on early 
death of patients with acute severe traumatic cervical spinal cord injury 
were uncertain. Conclusion: The factors reflecting disease severity and 
occurrence of related complications were more important in predicting the 
early death among patients with acute severe traumatic cervical spinal cord 
injury, while the influence of age, surgical manipulation etc. were minor 
factors.
EMTREE DRUG INDEX TERMS
  steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cause of death; cervical spinal cord injury (etiology); risk assessment; 
EMTREE MEDICAL INDEX TERMS
  APACHE; article; controlled study; dislocation; falling; fever; fracture; gastrointestinal hemorrhage; health survey; human; hyponatremia; injury severity; lung infection; major clinical study; mortality; multiple organ failure; neurogenic shock; respiratory failure; risk factor; shock; survival; tracheostomy; traffic accident; traumatic brain injury; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  English, Chinese
EMBASE ACCESSION NUMBER
  2013703513
MEDLINE PMID
  23663581 (http://www.ncbi.nlm.nih.gov/pubmed/23663581)
PUI
  L370203888
DOI
  10.3760/cma.j.issn.2095-4352.2013.05.014
FULL TEXT LINK
  http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2013.05.014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10030603&id=doi:10.3760%2Fcma.j.issn.2095-4352.2013.05.014&atitle=Analysis+of+the+risk+factors+for+early+death+in+acute+severe+traumatic+cervical+spinal+cord+injury&stitle=Chin.+Crit.+Care+Med.&title=Chinese+Critical+Care+Medicine&volume=25&issue=5&spage=294&epage=297&aulast=Leng&aufirst=Yu-Xin&auinit=Y.-X.&aufull=Leng+Y.-X.&coden=&isbn=&pages=294-297&date=2013&auinit1=Y&auinitm=-X
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 527
TITLE
  Survival of patients with spinal muscular atrophy type 1
AUTHOR NAMES
  Gregoretti C.; Ottonello G.; Testa M.B.C.; Mastella C.; Ravà L.; Bignamini E.; Veljkovic A.; Cutrera R.
AUTHOR ADDRESSES
  (Gregoretti C.) Department of Emergency and Intensive Care, Città Della 
Salute e Della Scienza, Turin, Italy.
(Ottonello G.; Testa M.B.C.; Cutrera R., renato.cutrera@opbg.net) Department 
of Pneumology, Bambino Gesù Children Hospital Research Institute, Rome, 
Italy.
(Mastella C.) Fondazione Ospedale Policlinico Maggiore Mangiagalli e Regina 
Elena, Milan, Italy.
(Ravà L.) Department of Epidemiology Units, Bambino Gesù Children Hospital 
Research Institute, Rome, Italy.
(Bignamini E.; Veljkovic A.) Pneumology Unit, Oirm-Sant'Anna, Turin, Italy.
CORRESPONDENCE ADDRESS
  R. Cutrera, Pneumology Unit, Bambino Gesù Children's Hospital, Piazza S 
Onofrio 4, 00165 Rome, Italy. Email: renato.cutrera@opbg.net
AiP/IP ENTRY DATE
  2013-05-10
FULL RECORD ENTRY DATE
  2013-05-21
SOURCE
  Pediatrics (2013) 131:5 (e1509-e1514). Date of Publication: May 2013
VOLUME
  131
ISSUE
  5
DATE OF PUBLICATION
  May 2013
ISSN
  0031-4005
  1098-4275 (electronic)
BOOK PUBLISHER
  American Academy of Pediatrics, 141 Northwest Point Blvd, P.O. Box 927, Elk 
Grove Village, United States.
ABSTRACT
  BACKGROUND: Spinal muscular atrophy type 1 (SMA1) is a progressive disease 
and is usually fatal in the first year of life. METHODS: A retrospective 
chart review was performed of SMA1 patients and their outcomes according to 
the following choices: letting nature take its course (NT); tracheostomy and 
invasive mechanical ventilation (TV); continuous noninvasive respiratory 
muscle aid (NRA), including noninvasive ventilation; and mechanically 
assisted cough. RESULTS: Of 194 consecutively referred patients enrolled in 
this study (103 males, 91 females), NT, TV, and NRA were chosen for 121 
(62.3%), 42 (21.7%), and 31 (16%) patients, respectively. Survival at ages 
24 and 48 months was higher in TV than NRA users: 95% (95% confidence 
interval: 81.8%-98.8%) and 67.7% (95% confidence interval: 46.7%-82%) at age 
24 months (P < .001) and 89.43% and 45% at age 48 months in the TV and NRA 
groups, respectively (P < .001). The choice of TV decreased from 50% 
(1992-1998) to 12.7% (2005-2010) (P < .005) with a nonstatistically 
significant increase for NT from 50% to 65%. The choice of NRA increased 
from 8.1% (1999-2004) to 22.7% (2005-2010) (P < .001). CONCLUSIONS: 
Long-term survival outcome is determined by the choice of the treatment. NRA 
and TV can prolong survival, with NRA showing a lower survival probability 
at ages 24 and 48 months. Copyright © 2013 by the American Academy of 
Pediatrics.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; survival; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  age distribution; article; artificial ventilation; child; female; human; major clinical study; male; noninvasive respiratory muscle aid; noninvasive ventilation; preschool child; priority journal; prognosis; respiratory failure (surgery, therapy); retrospective study; survival rate; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013283605
MEDLINE PMID
  23610208 (http://www.ncbi.nlm.nih.gov/pubmed/23610208)
PUI
  L368844701
DOI
  10.1542/peds.2012-2278
FULL TEXT LINK
  http://dx.doi.org/10.1542/peds.2012-2278
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00314005&id=doi:10.1542%2Fpeds.2012-2278&atitle=Survival+of+patients+with+spinal+muscular+atrophy+type+1&stitle=Pediatrics&title=Pediatrics&volume=131&issue=5&spage=&epage=&aulast=Gregoretti&aufirst=Cesare&auinit=C.&aufull=Gregoretti+C.&coden=PEDIA&isbn=&pages=-&date=2013&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 528
TITLE
  Spinal subdural hematoma in the setting of atlanto-occipital dislocation: 
The case for early aggressive management
AUTHOR NAMES
  Tymchak Z.; Kelly M.; Woo A.; Meguro K.
AUTHOR ADDRESSES
  (Tymchak Z.; Kelly M.; Woo A.; Meguro K.) Saskatoon, Canada.
CORRESPONDENCE ADDRESS
  Z. Tymchak, Saskatoon, Canada.
FULL RECORD ENTRY DATE
  2013-07-01
SOURCE
  Canadian Journal of Neurological Sciences (2013) 40:3 SUPPL. 1 (S52)
VOLUME
  40
ISSUE
  3
FIRST PAGE
  S52
CONFERENCE NAME
  48th Annual Congress of the Canadian Neurological Sciences Federation
CONFERENCE LOCATION
  Montreal, QC, Canada
CONFERENCE DATE
  2013-06-12 to 2013-06-14
ISSN
  0317-1671
BOOK PUBLISHER
  Canadian Journal of Neurological Sciences
ABSTRACT
  Background: Traumatic spinal subdural hematomas (SSDH) are rare. Few cases 
have been reported in the setting of atlanto-occipital dislocation. Methods: 
We present the case of a 31-year-old gentleman who sustained polytrauma from 
a motor vehicle accident. He presented with partial loss of brainstem 
reflexes and hemodynamic instability, yet was able to follow simple 
commands. Imaging revealed atlanto-occipital subluxation and SSDH extending 
from the foramen magnum to C4/5. There was little to no supratentorial 
pathology. The patient was treated with an occiput-C4 decompression and 
fusion and evacuation of the SSDH. Results: The patient underwent an 
extended stay in hospital but was eventually weaned from his tracheostomy 
and has since been transferred to our rehabilitation centre. He was able to 
communicate verbally and displayed good cognitive capacity. Conclusions: 
Patients suffering traumatic atlanto-occipital injuries with or without SSDH 
often die prior to reaching medical care. Our experience suggests that 
survivors should be managed aggressively regardless of their clinical 
presentation. This is particularly true in those patients with injuries 
confined to the cervico-medullary region as they may have better functional 
outcomes given the relative sparing of the higher cortical centres.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal hematoma; 
EMTREE MEDICAL INDEX TERMS
  brain stem; decompression; foramen magnum; hospital; human; imaging; injury; medical care; multiple trauma; pathology; patient; reflex; rehabilitation; subluxation; survivor; tracheostomy; traffic accident; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71096176
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03171671&id=doi:&atitle=Spinal+subdural+hematoma+in+the+setting+of+atlanto-occipital+dislocation%3A+The+case+for+early+aggressive+management&stitle=Can.+J.+Neurol.+Sci.&title=Canadian+Journal+of+Neurological+Sciences&volume=40&issue=3&spage=S52&epage=&aulast=Tymchak&aufirst=Z.&auinit=Z.&aufull=Tymchak+Z.&coden=&isbn=&pages=S52-&date=2013&auinit1=Z&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 529
TITLE
  Rehabilitation of cervical spinal cord injury resulting from tissue 
plasminogen activator treatment for acute ischemic stroke
AUTHOR NAMES
  Vuong N.L.N.; Oleson C.V.; Ditunno J.F.
AUTHOR ADDRESSES
  (Vuong N.L.N.; Oleson C.V.; Ditunno J.F.) Department of Rehabilitation 
Medicine, Jefferson Medical College, Thomas Jefferson University, 
Philadelphia, United States.
CORRESPONDENCE ADDRESS
  N.L.N. Vuong, Department of Rehabilitation Medicine, Jefferson Medical 
College, Thomas Jefferson University, Philadelphia, United States.
FULL RECORD ENTRY DATE
  2013-10-11
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2013) 19:1 (39-40). Date of 
Publication: May 2013
VOLUME
  19
ISSUE
  1
FIRST PAGE
  39
LAST PAGE
  40
DATE OF PUBLICATION
  May 2013
CONFERENCE NAME
  40th Anniversary Annual Scientific Meeting of the American Spinal Injury 
Association, ASIA 2013
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2013-05-06 to 2013-05-08
ISSN
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc.
ABSTRACT
  Objective: To illustrate rehabilitation challenges in autonomic and 
sensorimotor function specific to patients with dual diagnoses of acute 
stroke and cervical spinal cord injury (SCI). Design: Case report and review 
of the literature. Participants/Methods: A 77-yearold man developed C5 
complete tetraplegia secondary to epidural hematoma following tissue 
plasminogen activator (tPA) administration. The latter had been given for 
acute ischemic stroke. After a prolonged ICU course, including C5-T8 spinal 
decompression surgery and ventilator-dependent respiratory failure, our 
patient was transferred to acute inpatient rehabilitation. Autonomic 
instability from combined cranial and spinal pathologies complicated his 
rehabilitation course. Results: Extracranial hemorrhage from tPA treatment 
of ischemic stroke occurs in 2%-13% of patients. Literature review reveals 
only 2 cases resulting in paraplegia. This is the first reported case 
involving tetraplegia. A patient with both cervical SCI and stroke presents 
unique challenges related to blood pressure and pulmonary management. In our 
patient's case, the possibility of autonomic dysreflexia required tighter 
blood pressure control and prevention of precipitating events from 
bladder/bowel origins to differentiate causes of hypertension. Pulmonary 
management was challenged by motor weakness, dysphagia from bulbar 
dysfunction, and copious secretions from parasympathetic (vagal) 
predominance. With tracheostomy placement, insufflator-exsufflator use, and 
the interdisciplinary care of physiatry, respiratory therapy, speech, 
occupational and physical therapy, the patient achieved a safe discharge 
home. Conclusion: The combination of acute stroke and cervical SCI is a rare 
event for which an interdisciplinary team approach is essential to 
successful rehabilitation.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  tissue plasminogen activator; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain ischemia; cervical spinal cord injury; rehabilitation; spine injury; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; autonomic dysreflexia; bleeding; blood pressure; blood pressure regulation; bodily secretions; bulbar paralysis; case report; cerebrovascular accident; decompression surgery; diagnosis; dysphagia; epidural hematoma; hospital patient; human; hypertension; male; paraplegia; pathology; patient; physical medicine; physiotherapy; prevention; quadriplegia; respiratory failure; sensorimotor function; speech; spinal cord decompression; tracheostomy; ventilator; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71184313
DOI
  10.1310/sci19S1-36
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci19S1-36
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci19S1-36&atitle=Rehabilitation+of+cervical+spinal+cord+injury+resulting+from+tissue+plasminogen+activator+treatment+for+acute+ischemic+stroke&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=19&issue=1&spage=39&epage=40&aulast=Vuong&aufirst=Nancy+L.N.&auinit=N.L.N.&aufull=Vuong+N.L.N.&coden=&isbn=&pages=39-40&date=2013&auinit1=N&auinitm=L.N.
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 530
TITLE
  First case of severe enterovirus 71 infection in Portugal
AUTHOR NAMES
  Venâncio P.; Oliveira M.; Silva R.; Conceição C.; Brito M.J.
AUTHOR ADDRESSES
  (Venâncio P.; Oliveira M.; Silva R.; Conceição C.; Brito M.J.) Pediatric 
Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar Central 
(CHLC), Lisbon, Portugal.
CORRESPONDENCE ADDRESS
  Pediatric Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar 
Central (CHLC), Lisbon, Portugal.
AiP/IP ENTRY DATE
  2013-06-26
FULL RECORD ENTRY DATE
  2013-06-28
SOURCE
  Pediatric Infectious Disease Journal (2013) 32:5 (581-582). Date of 
Publication: May 2013
VOLUME
  32
ISSUE
  5
FIRST PAGE
  581
LAST PAGE
  582
DATE OF PUBLICATION
  May 2013
ISSN
  0891-3668
  1532-0987 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
EMTREE DRUG INDEX TERMS
  aciclovir; C reactive protein (endogenous compound); ceftriaxone; ciprofloxacin; glucose (endogenous compound); immunoglobulin (intravenous drug administration); immunoglobulin G (endogenous compound); methylprednisolone; nitric oxide (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  enterovirus 71 infection (diagnosis); Enterovirus A71; Enterovirus infection (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  brain atrophy; case report; central nervous system infection; cervical spinal cord injury; child; coma; disease severity; drug pulse therapy; encephalitis; flaccid paralysis; glucose blood level; hand foot and mouth disease; heart arrest; high frequency ventilation; human; hypotension; immunoelectrophoresis; letter; leukocyte count; lung edema; male; newborn intensive care; nuclear magnetic resonance imaging; Portugal; preschool child; priority journal; reverse transcription polymerase chain reaction; spastic paresis; tracheostomy; 
CAS REGISTRY NUMBERS
  C reactive protein (9007-41-4)
  aciclovir (59277-89-3)
  ceftriaxone (73384-59-5, 74578-69-1)
  ciprofloxacin (85721-33-1)
  glucose (50-99-7, 84778-64-3)
  immunoglobulin (9007-83-4)
  immunoglobulin G (97794-27-9)
  methylprednisolone (6923-42-8, 83-43-2)
  nitric oxide (10102-43-9)
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013383660
PUI
  L369132031
DOI
  10.1097/INF0b013e31828689ab
FULL TEXT LINK
  http://dx.doi.org/10.1097/INF0b013e31828689ab
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08913668&id=doi:10.1097%2FINF0b013e31828689ab&atitle=First+case+of+severe+enterovirus+71+infection+in+Portugal&stitle=Pediatr.+Infect.+Dis.+J.&title=Pediatric+Infectious+Disease+Journal&volume=32&issue=5&spage=581&epage=582&aulast=Ven%C3%A2ncio&aufirst=Paulo&auinit=P.&aufull=Ven%C3%A2ncio+P.&coden=PIDJE&isbn=&pages=581-582&date=2013&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 531
TITLE
  Current and emerging management options for patients with Morquio A syndrome
AUTHOR NAMES
  Algahim M.F.; Almassi G.H.
AUTHOR ADDRESSES
  (Algahim M.F.; Almassi G.H., halmassi@mcw.edu) Division of Cardiothoracic 
Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
CORRESPONDENCE ADDRESS
  G. H. Almassil, Division of Cardiothoracic Surgery, Medical College of 
Wisconsin, 9200 W Wisconsin Avenue, East Clinic Building, Milwaukee, WI 
53226, United States. Email: halmassi@mcw.edu
AiP/IP ENTRY DATE
  2013-04-05
FULL RECORD ENTRY DATE
  2013-04-19
SOURCE
  Therapeutics and Clinical Risk Management (2013) 9:1 (45-53). Date of 
Publication: 2013
VOLUME
  9
ISSUE
  1
FIRST PAGE
  45
LAST PAGE
  53
DATE OF PUBLICATION
  2013
ISSN
  1176-6336
  1178-203X (electronic)
BOOK PUBLISHER
  DOVE Medical Press Ltd., PO Box 300-008, Albany, Auckland, New Zealand.
ABSTRACT
  Morquio A syndrome is a lysosomal storage disease associated with 
mucopolysaccharidosis. It is caused by a deficiency of the lysosomal enzyme, 
N-acetylgalactosamine--6-sulfate sulfatase, which leads to accumulation of 
keratan sulfate and condroitin-6 sulfate in multiple organs. Patients 
present with multisystemic complications involving the musculoskeletal, 
respiratory, cardiovascular, and digestive systems. Presently, there is no 
definitive cure, and current management options are palliative. Enzyme 
replacement therapy and hematopoietic stem cell therapy have been proven 
effective in certain lysosomal storage diseases, and current investigations 
are underway to evaluate the effectiveness of these therapies and others for 
the treatment of Morquio A syndrome. This review discusses the current and 
emerging treatment options for Morquio A syndrome, citing examples of the 
treatment of other mucopolysaccharidoses. © 2013 Algahim and Almassi, 
publisher and licensee Dove Medical Press Ltd.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); chondroitin 6 sulfate; elosulfase alfa (clinical trial, drug therapy); iduronate 2 sulfatase (drug therapy); keratan sulfate; levo iduronidase (drug therapy); lysosome enzyme; n acetylgalactosamine 6 sulfatase; placebo; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Morquio a syndrome (drug therapy, diagnosis, disease management, drug 
therapy, etiology, prevention, therapy); Morquio syndrome (drug therapy, diagnosis, disease management, drug therapy, 
etiology, prevention, therapy); 
EMTREE MEDICAL INDEX TERMS
  adenoidectomy; airway obstruction (complication, therapy); aortic valve disease (complication, surgery); aortic valve replacement; atlantoaxial subluxation; bioaccumulation; cervical myelopathy (complication); conduction deafness; cornea disease; drug efficacy; drug safety; drug tolerability; dwarfism; endotracheal intubation; enzyme deficiency; enzyme replacement; gene therapy; hematopoietic stem cell transplantation; hemiplegia (complication); human; Hunter syndrome (drug therapy); Hurler syndrome (drug therapy); kyphoscoliosis (complication); ligament disease; Maroteaux Lamy syndrome (drug therapy); mitral valve disease (complication); muscle weakness (complication); neurogenic bladder (complication); neurogenic bowel (complication); neurologic disease (complication); nonhuman; otitis media (drug therapy, surgery); perception deafness; photophobia (complication); pigeon thorax; quadriplegia (complication); respiratory tract infection (complication, drug therapy); review; sleep disordered breathing (complication, surgery); spinal cord compression (complication); stunting; tonsillectomy; tracheostomy; tympanostomy tube; valgus knee; weakness; 
DRUG TRADE NAMES
  bmn 110  , United StatesBiomarin

DRUG MANUFACTURERS
   (United States)Biomarin
CAS REGISTRY NUMBERS
  chondroitin 6 sulfate (25322-46-7)
  iduronate 2 sulfatase (1271734-34-9, 50936-59-9)
  keratan sulfate (69992-87-6, 9056-36-4)
  n acetylgalactosamine 6 sulfatase (59299-00-2, 9025-60-9)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Human Genetics (22)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
CLINICAL TRIAL NUMBERS
  ClinicalTrials.gov (NCT01242111, NCT01275066, NCT01415427, NCT01515956, NCT01609062, NCT01697139)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013194736
PUI
  L368589133
DOI
  10.2147/TCRM.S24771
FULL TEXT LINK
  http://dx.doi.org/10.2147/TCRM.S24771
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11766336&id=doi:10.2147%2FTCRM.S24771&atitle=Current+and+emerging+management+options+for+patients+with+Morquio+A+syndrome&stitle=Ther.+Clin.+Risk+Manage.&title=Therapeutics+and+Clinical+Risk+Management&volume=9&issue=1&spage=45&epage=53&aulast=Algahim&aufirst=Mohamed+F.&auinit=M.F.&aufull=Algahim+M.F.&coden=&isbn=&pages=45-53&date=2013&auinit1=M&auinitm=F
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 532
TITLE
  [Diaphragm pacemaker: alternative for chronic ventilatory support].
ORIGINAL (NON-ENGLISH) TITLE
  Diafragmapacemaker: alternatief voor chronische beademing.
AUTHOR NAMES
  Hazenberg A.; Hofker S.S.; van der Aa J.G.; Nieuwenhuis J.A.; Kerstjens H.A.; Wijkstra P.J.
AUTHOR ADDRESSES
  (Hazenberg A.) Universitair Medisch Centrum Groningen, Afd. 
Longziekten-Centrum voor Thuisbeademing, Groningen, the Netherlands.
(Hofker S.S.; van der Aa J.G.; Nieuwenhuis J.A.; Kerstjens H.A.; Wijkstra 
P.J.)
CORRESPONDENCE ADDRESS
  A. Hazenberg, Universitair Medisch Centrum Groningen, Afd. 
Longziekten-Centrum voor Thuisbeademing, Groningen, the Netherlands. Email: 
a.hazenberg@umcg.nl
FULL RECORD ENTRY DATE
  2013-04-19
SOURCE
  Nederlands tijdschrift voor geneeskunde (2013) 157:5 (A5572). Date of 
Publication: 2013
VOLUME
  157
ISSUE
  5
DATE OF PUBLICATION
  2013
ISSN
  1876-8784 (electronic)
ABSTRACT
  Currently, more than 2200 patients in the Netherlands receive chronic 
ventilatory support. In the majority of patients this leads to increased 
survival without any complications. Nevertheless, in case of ventilatory 
support via a mask, problems such as skin irritation, leakage and 
claustrophobia can occur. In case of tracheostomy, it can lead to increased 
pulmonary secretion. Diaphragm pacing with an external pacemaker might be an 
attractive alternative to prevent these symptoms as it can replace 
ventilatory support by mask or tracheostomy. Current indications are 
patients with spinal cord injury or with congenital central hypoventilation 
syndrome who are chronically respiratory insufficient. In our experience, 
patients can be completely or partially weaned from mechanical ventilation 
when using the diaphragm pacer. In the Netherlands, the technique is only 
performed at the University Medical Center Groningen.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial heart pacemaker; diaphragm; respiratory failure (therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; human; innervation; pathophysiology; treatment outcome; 
LANGUAGE OF ARTICLE
  Dutch
MEDLINE PMID
  23369820 (http://www.ncbi.nlm.nih.gov/pubmed/23369820)
PUI
  L368718759
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18768784&id=doi:&atitle=%5BDiaphragm+pacemaker%3A+alternative+for+chronic+ventilatory+support%5D.&stitle=Ned+Tijdschr+Geneeskd&title=Nederlands+tijdschrift+voor+geneeskunde&volume=157&issue=5&spage=&epage=&aulast=Hazenberg&aufirst=Anda&auinit=A.&aufull=Hazenberg+A.&coden=&isbn=&pages=-&date=2013&auinit1=A&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 533
TITLE
  Timing of tracheostomy after anterior cervical spine fixation
AUTHOR NAMES
  Babu R.; Owens T.R.; Thomas S.; Karikari I.O.; Grunch B.H.; Moreno J.R.; Lad S.P.; Bagley C.A.
AUTHOR ADDRESSES
  (Babu R.; Owens T.R.; Thomas S.; Karikari I.O.; Grunch B.H.; Moreno J.R.; 
Lad S.P.; Bagley C.A., carlos.bagley@duke.edu) Division of Neurosurgery, 
Department of Surgery, Duke University Medical Center, PO Box 3087, Durham, 
NC 27710, United States.
CORRESPONDENCE ADDRESS
  C.A. Bagley, Division of Neurosurgery, Department of Surgery, Duke 
University Medical Center, PO Box 3087, Durham, NC 27710, United States. 
Email: carlos.bagley@duke.edu
AiP/IP ENTRY DATE
  2013-04-23
FULL RECORD ENTRY DATE
  2013-04-25
SOURCE
  Journal of Trauma and Acute Care Surgery (2013) 74:4 (961-966). Date of 
Publication: April 2013
VOLUME
  74
ISSUE
  4
FIRST PAGE
  961
LAST PAGE
  966
DATE OF PUBLICATION
  April 2013
ISSN
  2163-0755
  2163-0763 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  BACKGROUND: Patients with cervical spinal cord injury frequently undergo 
early anterior cervical spine fixation (ACSF) and tracheostomy procedures to 
reduce further deterioration, to reduce risk of pulmonary complications, and 
to improve patient mobilization. However, tracheostomy is often delayed 
because of the risk of cross contamination as a result of the proximity to 
the ACSF incision site. Currently, there is a paucity of studies evaluating 
this outcome to determine the safety of early tracheostomy after ACSF. In 
this study, we have evaluated the outcomes and complications associated with 
early tracheostomy placement. METHODS: We performed a retrospective review 
of all patients who underwent tracheostomy placement and ACSF during the 
same hospitalization between 2005 and 2010. A variety of patient and 
procedural data were collected, including demographics, timing of ACSF and 
tracheostomy, length of hospitalization, indication for surgery, American 
Spinal Injuries Association and Glasgow Coma Scale scores on admission, 
reason for tracheostomy, method of tracheostomy, and complications. RESULTS: 
Of the 1,184 patients who underwent an ACSF, 20 (1.7%) required a 
postfixation tracheostomy. Tracheostomy was performed at mean (SD) of 6.9 
(4.2) days after ACSF, ranging from 0 to 17 days. Although nearly half of 
all patients underwent postfixation tracheostomy within 6 days, no wound or 
implant infection was seen to occur in any patient. Ten patients (50%) 
developed ventilator-associated pneumonia, with most cases occurring before 
tracheostomy (90% vs. 10%, p < 0.0001). Univariate analysis only revealed 
late tracheostomy to significantly increase the risk of complications (odds 
ratio, 9.33; 95% confidence interval, 1.19-73.0; p = 0.033). Analysis of all 
studies in the literature revealed a 1% cross-infection rate, with no cases 
involving implant contamination. CONCLUSION: Our findings suggest that early 
tracheostomy can be performed safely after cervical spine fixation surgery, 
with no patients developing incisional or implant infections. As the risk of 
cross contamination is only 1%, early tracheostomy should be strongly 
considered because of its potential benefits. LEVEL OF EVIDENCE: 
Therapeutic/care management, level IV. Copyright © 2013 Lippincott Williams 
&Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical spine fixation; spine stabilization; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cardiopulmonary arrest; female; Glasgow coma scale; hematoma (complication); human; injury scale; length of stay; major clinical study; male; outcome assessment; postoperative complication (complication); priority journal; retrospective study; ventilator associated pneumonia; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013237472
MEDLINE PMID
  23511132 (http://www.ncbi.nlm.nih.gov/pubmed/23511132)
PUI
  L368723548
DOI
  10.1097/TA.0b013e3182826ea4
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e3182826ea4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630755&id=doi:10.1097%2FTA.0b013e3182826ea4&atitle=Timing+of+tracheostomy+after+anterior+cervical+spine+fixation&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=74&issue=4&spage=961&epage=966&aulast=Babu&aufirst=Ranjith&auinit=R.&aufull=Babu+R.&coden=&isbn=&pages=961-966&date=2013&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 534
TITLE
  A rare case of a penetrating,life-threatening injury to the oropharynx
AUTHOR NAMES
  Crockett A.; Shah S.; Pickles J.
AUTHOR ADDRESSES
  (Crockett A.; Shah S.; Pickles J.) Luton and Dunstable Hospital, Luton, 
United Kingdom.
CORRESPONDENCE ADDRESS
  A. Crockett, Luton and Dunstable Hospital, Luton, United Kingdom.
FULL RECORD ENTRY DATE
  2013-04-30
SOURCE
  Journal of Laryngology and Otology (2013) 127:4 (8). Date of Publication: 
April 2013
VOLUME
  127
ISSUE
  4
FIRST PAGE
  8
DATE OF PUBLICATION
  April 2013
CONFERENCE NAME
  142nd Semon Club
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2011-11-10 to 2011-11-10
ISSN
  0022-2151
BOOK PUBLISHER
  Cambridge University Press
ABSTRACT
  Case report A six-year-old child presented to the accident and emergency 
department after he had been found in the street apnoeic and cyanosed with a 
broken pencil embedded in his mouth and a Glasgow Coma Score of 3. In the 
accident and emergency department, the child's Glasgow Coma Score fluctuated 
between 8 and 13. A penetrating injury of the soft palate was noted, and a 
provisional diagnosis of penetrating intracranial injury was made. 
Antibiotics were given and the child was intubated and ventilated. Computed 
tomography (CT) showed no evidence of brain or spinal cord injury. 
Examination under anaesthesia revealed a small penetrating wound in the 
nasopharynx with cerebrospinal fluid (CSF) leakage. The child was 
transferred, intubated, to Great Ormond Street Hospital. Attempted 
extubation after 72 hours failed because of a poor gag reflex and 
aspiration. Magnetic resonance imaging (MRI) and magnetic resonance 
angiography showed an ill-defined lesion in the right side of the medulla 
and upper spinal cord. Antibiotics were continued. After 9 days, a 
tracheostomy was fashioned. The child's level of consciousness subsequently 
improved, but there was evidence of a partial bulbar palsy together with 
left facial and upper and lower limb weakness. The CSF leak ceased 
spontaneously within 72 hours. Further management consisted of nasogastric 
tube feeding and rehabilitation, including swallowing therapy and 
physiotherapy. After six months, there was still a mild left-sided limb 
weakness. Conclusion This unusual penetrating injury of the brain stem was 
diagnosed on clinical grounds and correct management instituted despite a 
normal CT scan. Suspicions were subsequently confirmed by MRI scanning, 
together with the development of focal neurological signs which became 
apparent following extubation.
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; oropharynx; 
EMTREE MEDICAL INDEX TERMS
  accident; anesthesia; aspiration; brain; brain stem; bulbar paralysis; case report; cerebrospinal fluid; child; coma; computer assisted tomography; consciousness; diagnosis; emergency ward; examination; extubation; hospital; human; leg; limb weakness; liquorrhea; magnetic resonance angiography; nasopharynx; neurologic disease; nose feeding; nuclear magnetic resonance imaging; penetrating trauma; physiotherapy; reflex; rehabilitation; soft palate; spinal cord; spinal cord injury; swallowing; therapy; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71044103
DOI
  10.1017/S0022215113000352
FULL TEXT LINK
  http://dx.doi.org/10.1017/S0022215113000352
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00222151&id=doi:10.1017%2FS0022215113000352&atitle=A+rare+case+of+a+penetrating%2Clife-threatening+injury+to+the+oropharynx&stitle=J.+Laryngol.+Otol.&title=Journal+of+Laryngology+and+Otology&volume=127&issue=4&spage=8&epage=&aulast=Crockett&aufirst=A.&auinit=A.&aufull=Crockett+A.&coden=&isbn=&pages=8-&date=2013&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 535
TITLE
  Perioperative antibiotic use for spinal surgery procedures in US children's 
hospitals
AUTHOR NAMES
  Mcleod L.M.; Keren R.; Gerber J.; French B.; Song L.; Sampson N.R.; Flynn J.; Dormans J.P.
AUTHOR ADDRESSES
  (Mcleod L.M., lisa.mcleod@me.com; Keren R.; Gerber J.; Song L.) Department 
of General Pediatrics, Center for Pediatric Clinical Effectiveness, 
Children's Hospital of Philadelphia, 3535 Market St, Ste 1509, Philadelphia, 
PA 19104, United States.
(Keren R.; French B.) Center for Clinical Epidemiology and Biostatistics, 
University of Pennsylvania School of Medicine, Philadelphia, PA, United 
States.
(Gerber J.) Division of Pediatric Infectious Diseases, Children's Hospital 
of Philadelphia, Philadelphia, PA, United States.
(Sampson N.R.; Flynn J.; Dormans J.P.) Division of Orthopaedic Surgery, 
Children's Hospital of Philadelphia, Philadelphia, PA, United States.
CORRESPONDENCE ADDRESS
  L.M. Mcleod, Department of General Pediatrics, Center for Pediatric Clinical 
Effectiveness, Children's Hospital of Philadelphia, 3535 Market St, Ste 
1509, Philadelphia, PA 19104, United States. Email: lisa.mcleod@me.com
AiP/IP ENTRY DATE
  2013-02-06
FULL RECORD ENTRY DATE
  2013-05-02
SOURCE
  Spine (2013) 38:7 (609-616). Date of Publication: 1 Apr 2013
VOLUME
  38
ISSUE
  7
FIRST PAGE
  609
LAST PAGE
  616
DATE OF PUBLICATION
  1 Apr 2013
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  STUDY DESIGN.: Retrospective cohort study using the Pediatric Health 
Information System database. OBJECTIVE.: To describe longitudinal patterns 
of prophylactic antibiotic use and determinants of antibiotic choice for 
spinal fusion surgical procedures performed at US children's hospitals. 
SUMMARY OF BACKGROUND DATA.: Surgical site infections (SSIs) account for a 
significant proportion of post-spinal surgery complications, particularly 
among children with complex conditions such as neuromuscular disease. 
Antimicrobial prophylaxis with intravenous cefazolin or cefuroxime has been 
a standard practice, but postoperative infections caused by organisms 
resistant to these antibiotics are increasing in prevalence. Studies 
describing the choice of antibiotic prophylaxis for pediatric spinal surgery 
are lacking. METHODS.: We included children 6 months to 18 years of age 
discharged from 37 US children's hospitals between January 1, 2006, and June 
30, 2009, with (1) an International Classification of Diseases, Ninth 
Revision, Clinical Modification (ICD-9-CM) procedure code indicating a 
spinal fusion and (2) combinations of diagnosis codes indicating adolescent 
idiopathic scoliosis (AIS) (n = 5617) or neuromuscular scoliosis (NMS) (n = 
3633). After identifying antibiotics ordered on the operative day, we 
described variation in broad-spectrum antibiotic use over time and measured 
associations between patient/surgery characteristics and antibiotic choice. 
RESULTS.: Prophylactic antibiotic choice varied across hospitals and over 
time. Broad-spectrum antibiotics were used in 37% of AIS and 52% of NMS 
operations. Seven (19%) hospitals used broad-spectrum coverage for more 80% 
of all cases. For NMS procedures, broad-spectrum antibiotic use was 
associated with patient characteristics known to be associated with high SSI 
risk. Use of vancomycin and broad gram-negative agents increased over time. 
CONCLUSION.: Broad-spectrum antimicrobial prophylaxis varied across 
hospitals and was often associated with known risk factors for SSI. These 
results highlight the need for future studies comparing the effectiveness of 
various prophylaxis strategies, particularly in high-risk subgroups. This 
research can inform the development of best practice for SSI prevention in 
spinal fusion procedures. © 2013, Lippincott Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  aminoglycoside; cefazolin; cephalosporin derivative; clindamycin; vancomycin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  antibiotic prophylaxis; perioperative period; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adolescent idiopathic scoliosis (surgery); adult; article; bladder dysfunction; cerebral palsy; child; cohort analysis; comorbidity; female; gastrostomy; Gram negative bacterium; Gram positive bacterium; human; infant; major clinical study; male; medical information system; neuromuscular scoliosis (surgery); pediatric surgery; preschool child; priority journal; retrospective study; risk factor; school child; scoliosis (surgery); spinal dysraphism (surgery); spine fusion; surgical infection (complication); tracheostomy; 
CAS REGISTRY NUMBERS
  cefazolin (25953-19-9, 27164-46-1)
  clindamycin (18323-44-9)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013250344
MEDLINE PMID
  23370689 (http://www.ncbi.nlm.nih.gov/pubmed/23370689)
PUI
  L52421244
DOI
  10.1097/BRS.0b013e318289b690
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e318289b690
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e318289b690&atitle=Perioperative+antibiotic+use+for+spinal+surgery+procedures+in+US+children%27s+hospitals&stitle=Spine&title=Spine&volume=38&issue=7&spage=609&epage=616&aulast=Mcleod&aufirst=Lisa+M.&auinit=L.M.&aufull=Mcleod+L.M.&coden=SPIND&isbn=&pages=609-616&date=2013&auinit1=L&auinitm=M
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 536
TITLE
  Ultrasound scanning for percutaneous dilatational tracheostomy: A systematic 
review
AUTHOR NAMES
  Pugh R.; Slater A.
AUTHOR ADDRESSES
  (Pugh R.; Slater A.) Glan Clwyd Hospital, Bodelwyddan, United Kingdom.
CORRESPONDENCE ADDRESS
  R. Pugh, Glan Clwyd Hospital, Bodelwyddan, United Kingdom.
FULL RECORD ENTRY DATE
  2013-04-12
SOURCE
  Critical Care (2013) 17 SUPPL. 2 (S60-S61). Date of Publication: 19 Mar 2013
VOLUME
  17
FIRST PAGE
  S60
LAST PAGE
  S61
DATE OF PUBLICATION
  19 Mar 2013
CONFERENCE NAME
  33rd International Symposium on Intensive Care and Emergency Medicine
CONFERENCE LOCATION
  Brussels, Belgium
CONFERENCE DATE
  2013-03-19 to 2013-03-22
ISSN
  1364-8535
BOOK PUBLISHER
  BioMed Central Ltd.
ABSTRACT
  Introduction Percutaneous dilatational tracheostomy (PDT) remains a 
frequently performed procedure in the ICU. However, there is great 
variability in the course of blood vessels in the pre-tracheal area. A 5% 
risk of clinically relevant bleeding was recently reported for patients 
undergoing PDT [1]. We conducted a systematic review of reports evaluating 
clinical outcomes following use of ultrasound scanning (US) for PDT. Methods 
Two investigators performed a search of the literature using the following 
databases: CENTRAL, Embase, MEDLINE and SCOPUS. The following eligibility 
criteria were used: population including adults >16 years managed in the 
ICU; use of ultrasound to guide decision-making pre-PDT or guide PDT 
performance; report of clinically relevant outcome measures. Nonrandomised 
controlled trials were classif ed according to Cochrane Non-Randomised Study 
Methods Group criteria [2] and evaluated for risk of bias. Results An 
initial search identif ed 2,043 reports, of which 10 studies met eligibility 
criteria: eight case series, one randomised controlled trial (RCT) and one 
prospective cohort study, incorporating 488 patients. Two studies specif 
cally reported data on patients with obesity (n = 29 patients) and one study 
reported data for a group of patients with spinal cord f xation (n = 6). US 
was used to guide decision to perform PDT or surgical tracheostomy in f ve 
studies, with decision to perform surgical tracheostomy ranging from 0 to 
27% of cases. US was used to guide insertion point in seven studies, and 
used real-time in four studies. Times to perform US-guided PDT were reported 
in four studies (ranging from 8 to 12 minutes). No studies compared time 
taken with or without US. Data on complications of procedure were reported 
in nine studies. Minor bleeding was reported for eight cases (1.6% overall). 
Prolonged bleeding was reported in two cases (0.4%). There were no episodes 
of catastrophic bleeding among 488 cases. High risk of bias was identif ed 
in f ve studies in terms of patient selection. An intervention protocol was 
not defined in three reports. No attempt was made at blinding any aspect of 
the 10 studies. Conclusion Use of US guidance could theoretically help 
minimise risk of haemorrhagic complications during PDT and perhaps reduce 
time taken to perform PDT. However, there is currently inadequate evidence 
from controlled cohort studies or RCTs to suggest that routine use for PDT 
in selected or unselected groups improves clinically relevant outcome 
measure.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  echography; emergency medicine; intensive care; systematic review; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; bleeding; blindness; blood vessel; case study; cohort analysis; controlled study; data base; decision making; Embase; human; obesity; patient; patient selection; population; procedures; randomized controlled trial; risk; spinal cord; ultrasound; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71030461
DOI
  10.1186/cc12101
FULL TEXT LINK
  http://dx.doi.org/10.1186/cc12101
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13648535&id=doi:10.1186%2Fcc12101&atitle=Ultrasound+scanning+for+percutaneous+dilatational+tracheostomy%3A+A+systematic+review&stitle=Crit.+Care&title=Critical+Care&volume=17&issue=&spage=S60&epage=S61&aulast=Pugh&aufirst=R.&auinit=R.&aufull=Pugh+R.&coden=&isbn=&pages=S60-S61&date=2013&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 537
TITLE
  Cervical spine arterio venous malformation
AUTHOR NAMES
  Parla G.; Ameh V.
AUTHOR ADDRESSES
  (Parla G., giridharparla@yahoo.com; Ameh V.) Department of Emergency 
Medicine, Tameside Hospital, Ashton-Under-Lyne, United Kingdom.
CORRESPONDENCE ADDRESS
  G. Parla, Department of Emergency Medicine, Tameside Hospital, 
Ashton-Under-Lyne, United Kingdom. Email: giridharparla@yahoo.com
AiP/IP ENTRY DATE
  2013-03-08
FULL RECORD ENTRY DATE
  2013-03-18
SOURCE
  BMJ Case Reports (2013) Article Number: 006928. Date of Publication: 2013
DATE OF PUBLICATION
  2013
ISSN
  1757-790X (electronic)
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  We present an unusual case of a young patient who presented to our emergency 
department with a history of sudden onset of pain on the left side of the 
neck and numbness to the left arm after lifting a small weight. Patient 
continued to work as normal for approximately 30 min after the event and 
then attended the emergency department as numbness in the left arm was not 
resolving. On examination there was no sensorymotor deficit in the lower 
limbs but neurological deficits were found in the upper limbs which made us 
suspect a diagnosis of cervical spine injury/brachial plexus. The patient 
then rapidly developed numbness in both upper and lower limbs and eventually 
became aphasic and developed a rapid, shallow respiration and was unable to 
maintain the airway. The patient was then intubated and ventilated. The 
patient was then transferred to a neurosurgical centre after the relevant 
investigations was found to have an arteriovenous malformation of spinal 
cord.
EMTREE DRUG INDEX TERMS
  analgesic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain arteriovenous malformation (diagnosis, therapy); cervical spinal cord injury (diagnosis, rehabilitation, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; brachial plexus injury (diagnosis); brain hemorrhage (diagnosis); case report; cervical spine injury (diagnosis); clinical feature; conservative treatment; deterioration; differential diagnosis; follow up; human; intubation; mechanical ventilator; medical decision making; neck pain; nuclear magnetic resonance imaging; paresthesia; physical examination; priority journal; rehabilitation care; repeat procedure; resuscitation; sensory dysfunction; tracheostomy; treatment outcome; vascular access; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013135865
MEDLINE PMID
  23349172 (http://www.ncbi.nlm.nih.gov/pubmed/23349172)
PUI
  L368436639
DOI
  10.1136/bcr-2012-006928
FULL TEXT LINK
  http://dx.doi.org/10.1136/bcr-2012-006928
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1757790X&id=doi:10.1136%2Fbcr-2012-006928&atitle=Cervical+spine+arterio+venous+malformation&stitle=BMJ+Case+Rep.&title=BMJ+Case+Reports&volume=&issue=&spage=&epage=&aulast=Parla&aufirst=Giridhar&auinit=G.&aufull=Parla+G.&coden=&isbn=&pages=-&date=2013&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 538
TITLE
  Brachytelephalangic chondrodysplasia punctata with a new hemizygous missense 
mutation in a neonate
AUTHOR NAMES
  Meyer S.; Löffler G.; Gencik M.; Fries P.; Papanagiotou P.; Oehl-Jaschkowitz B.; Gortner L.
AUTHOR ADDRESSES
  (Meyer S., sascha.meyer@uks.eu; Löffler G.; Gortner L.) Department of 
Paediatrics and Neonatology, University Hospital of Saarland, Homburg, 
Germany.
(Meyer S., sascha.meyer@uks.eu; Gortner L.) Section Neuropaediatrics, 
University Hospital of Saarland, Homburg, Germany.
(Gencik M.) Diagenos Gemeinschaftspraxis für Humangenetik, Osnabrück, 
Germany.
(Fries P.) Clinic of Diagnostic and Interventional Radiology, University 
Hospital of Saarland, Homburg, Germany.
(Papanagiotou P.) Clinic of Diagnostic and Interventional Neuroradiology, 
University Hospital of Saarland, Homburg, Germany.
(Oehl-Jaschkowitz B.) Humangenetische Praxis, Homburg, Germany.
CORRESPONDENCE ADDRESS
  S. Meyer, Department of Neonatology and Paediatrics, University Hospital of 
Saarland, Building 9, 66421 Homburg, Germany. Email: sascha.meyer@uks.eu
AiP/IP ENTRY DATE
  2013-02-13
FULL RECORD ENTRY DATE
  2013-03-08
SOURCE
  American Journal of Medical Genetics, Part A (2013) 161:3 (626-629). Date of 
Publication: March 2013
VOLUME
  161
ISSUE
  3
FIRST PAGE
  626
LAST PAGE
  629
DATE OF PUBLICATION
  March 2013
ISSN
  1552-4825
  1552-4833 (electronic)
BOOK PUBLISHER
  Wiley-Liss Inc., 111 River Street, Hoboken, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chondrodysplasia punctata (diagnosis); missense mutation; 
EMTREE MEDICAL INDEX TERMS
  ARSE gene; article; artificial ventilation; case report; diaphragm paralysis; echography; exon; flaccid paralysis; gene; gene identification; hemizygosity; hiccup; human; hydramnios; infant; lung hypoplasia (therapy); male; midface hypoplasia; mutational analysis; newborn; nose malformation; nuclear magnetic resonance imaging; pneumothorax (therapy); priority journal; quadriplegia; spinal cord compression (surgery); spinal cord decompression; thorax radiography; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Human Genetics (22)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013124008
MEDLINE PMID
  23401300 (http://www.ncbi.nlm.nih.gov/pubmed/23401300)
PUI
  L52439425
DOI
  10.1002/ajmg.a.35758
FULL TEXT LINK
  http://dx.doi.org/10.1002/ajmg.a.35758
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15524825&id=doi:10.1002%2Fajmg.a.35758&atitle=Brachytelephalangic+chondrodysplasia+punctata+with+a+new+hemizygous+missense+mutation+in+a+neonate&stitle=Am.+J.+Med.+Genet.+Part+A&title=American+Journal+of+Medical+Genetics%2C+Part+A&volume=161&issue=3&spage=626&epage=629&aulast=Meyer&aufirst=Sascha&auinit=S.&aufull=Meyer+S.&coden=AJMGD&isbn=&pages=626-629&date=2013&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 539
TITLE
  Maternal vitamin K deficient embryopathy: Association with hyperemesis 
gravidarum and Crohn disease
AUTHOR NAMES
  Toriello H.V.; Erick M.; Alessandri J.-L.; Bailey D.; Brunetti-Pierri N.; Cox H.; Fryer A.; Marty D.; Mccurdy C.; Mulliken J.B.; Murphy H.; Omlor J.; Pauli R.M.; Ranells J.D.; Sanchez-Valle A.; Tobiasz A.; Van Maldergem L.; Lin A.E.
AUTHOR ADDRESSES
  (Toriello H.V., toriello@msu.edu; Tobiasz A.) Genetic Services, Spectrum 
Health, Grand Rapids, MI, United States.
(Toriello H.V., toriello@msu.edu) Department of Pediatrics/Human 
Development, College of Human Medicine, Michigan State University, Grand 
Rapids, MI, United States.
(Erick M.) Brigham and Women's Hospital, Center for Women and Newborns, 
Boston, MA, United States.
(Alessandri J.-L.) CHU de la Réunion, Service de Réanimation Néonatale None, 
Réunion, Naples, Italy.
(Bailey D.; Brunetti-Pierri N.; Mccurdy C.) Department of Pediatrics, 
Federico II University of Naples, Naples, Italy.
(Brunetti-Pierri N.) Telethon Institute of Genetics and Medicine, Naples, 
Italy.
(Brunetti-Pierri N.) Birmingham Women's Hospital, West Midlands Regional 
Genetics Service, Birmingham, United Kingdom.
(Cox H.) Royal Liverpool Children's Hospital (Alder Hey), Liverpool, United 
Kingdom.
(Fryer A.) Virginia Piper Cancer Institute of Unity Hospital, Fridley, MN, 
United States.
(Marty D.) Health Park Medical Center, Ft. Myers, FL, United States.
(Mulliken J.B.) Department of Plastic Surgery, Children's Hospital, Boston, 
MA, United States.
(Murphy H.) Central Manchester University Hospital, Manchester, United 
Kingdom.
(Omlor J.) College of Human Medicine, Michigan State University, Grand 
Rapids, MI, United States.
(Pauli R.M.) Genetics Center, Madison, WI, United States.
(Ranells J.D.; Sanchez-Valle A.) Department of Pediatrics, University of 
South Florida, College of Medicine, Tampa, FL, United States.
(Van Maldergem L.) Institut de Pathologie et de Génétique, Centre de 
Génétique Humaine, Loverval, Belgium.
(Lin A.E.) Genetics Unit, Mass General Hospital for Children, Boston, MA, 
United States.
CORRESPONDENCE ADDRESS
  H.V. Toriello, 25 Michigan St., Suite 2000, Grand Rapids, MI 49503, United 
States. Email: toriello@msu.edu
AiP/IP ENTRY DATE
  2013-02-20
FULL RECORD ENTRY DATE
  2013-03-08
SOURCE
  American Journal of Medical Genetics, Part A (2013) 161:3 (417-429). Date of 
Publication: March 2013
VOLUME
  161
ISSUE
  3
FIRST PAGE
  417
LAST PAGE
  429
DATE OF PUBLICATION
  March 2013
ISSN
  1552-4825
  1552-4833 (electronic)
BOOK PUBLISHER
  Wiley-Liss Inc., 111 River Street, Hoboken, United States.
ABSTRACT
  Chondrodysplasia punctata (CDP) is an etiologically heterogeneous disorder 
characterized by the radiographic finding of stippled epiphyses (punctate 
calcifications). It is often accompanied by a characteristic facial 
appearance, known as the Binder phenotype, which is attributed to hypoplasia 
of the nasal cartilages; abnormal distal phalanges (brachytelephalangy) are 
a common component manifestation as well. We report eight patients with a 
Binder phenotype with or without CDP who all shared a known or suspected 
maternal deficiency of vitamin K. We suspect that this phenotype is probably 
under recognized, and we hope to increase awareness about the maternal risk 
factors, especially hyperemesis gravidarum, which lead to nutritional 
deficiency. © 2013 Wiley Periodicals, Inc.
EMTREE DRUG INDEX TERMS
  antiemetic agent (drug therapy, intravenous drug administration); azathioprine (drug therapy); metoclopramide (drug therapy); ondansetron (drug therapy); prednisolone (drug therapy); prothrombin (endogenous compound); vitamin K group (drug therapy, subcutaneous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Crohn disease (drug therapy, drug therapy); embryopathy (diagnosis); hyperemesis gravidarum (drug therapy, drug therapy, therapy); vitamin K deficiency (drug therapy, diagnosis, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; anemia; article; bone radiography; brachydactyly (diagnosis); calcification (diagnosis); calcifying chondrodystrophy (diagnosis); child; chromosome analysis; clinical article; compression therapy; disease association; disease severity; echography; electrolyte intake; epistaxis; faintness; female; fetus distress; gestation period; heterotopia (diagnosis); human; hypoalbuminemia (diagnosis); hypokalemia (diagnosis); hypomagnesemia; hyponatremia (diagnosis); hypoproteinemia (diagnosis); ketonuria; laboratory test; male; midface hypoplasia (diagnosis); muscle weakness; newborn jaundice (therapy); nose obstruction (complication); nuclear magnetic resonance imaging; obesity; phototherapy; physical examination; priority journal; respiratory distress (therapy); respiratory failure (complication); school child; sequence analysis; spinal cord compression (diagnosis, surgery); spine surgery; subglottic stenosis; tracheostomy; upper respiratory tract infection; vomiting; 
CAS REGISTRY NUMBERS
  azathioprine (446-86-6)
  metoclopramide (12707-59-4, 2576-84-3, 364-62-5, 7232-21-5)
  ondansetron (103639-04-9, 116002-70-1, 99614-01-4)
  prednisolone (50-24-8)
  prothrombin (9001-26-7)
  vitamin K group (12001-79-5)
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013123979
MEDLINE PMID
  23404932 (http://www.ncbi.nlm.nih.gov/pubmed/23404932)
PUI
  L52445406
DOI
  10.1002/ajmg.a.35765
FULL TEXT LINK
  http://dx.doi.org/10.1002/ajmg.a.35765
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15524825&id=doi:10.1002%2Fajmg.a.35765&atitle=Maternal+vitamin+K+deficient+embryopathy%3A+Association+with+hyperemesis+gravidarum+and+Crohn+disease&stitle=Am.+J.+Med.+Genet.+Part+A&title=American+Journal+of+Medical+Genetics%2C+Part+A&volume=161&issue=3&spage=417&epage=429&aulast=Toriello&aufirst=Helga+V.&auinit=H.V.&aufull=Toriello+H.V.&coden=AJMGD&isbn=&pages=417-429&date=2013&auinit1=H&auinitm=V
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 540
TITLE
  Correction of spine deformity in patients with melnick-needles syndrome: 
Report of 2 cases and literature review
AUTHOR NAMES
  Lykissas M.G.; Crawford A.H.; Shufflebarger H.L.; Gaines S.; Permal V.
AUTHOR ADDRESSES
  (Lykissas M.G.; Crawford A.H., alvin.crawford@cchmc.org; Gaines S.; Permal 
V.) Cincinnati Children's Hospital Medical Center, Division of Orthopaedic 
Surgery, University of Cincinnati, 3333 Burnet Avenue, MLC 2017, Cincinnati, 
OH 45229, United States.
(Shufflebarger H.L.) Department of Orthopaedic Surgery, Miami Children's 
Hospital, Miami, FL, United States.
CORRESPONDENCE ADDRESS
  A.H. Crawford, Cincinnati Children's Hospital Medical Center, Division of 
Orthopaedic Surgery, University of Cincinnati, 3333 Burnet Avenue, MLC 2017, 
Cincinnati, OH 45229, United States. Email: alvin.crawford@cchmc.org
AiP/IP ENTRY DATE
  2013-02-22
FULL RECORD ENTRY DATE
  2013-03-04
SOURCE
  Journal of Pediatric Orthopaedics (2013) 33:2 (170-174). Date of 
Publication: March 2013
VOLUME
  33
ISSUE
  2
FIRST PAGE
  170
LAST PAGE
  174
DATE OF PUBLICATION
  March 2013
ISSN
  0271-6798
  1539-2570 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  BACKGROUND:: Melnick-Needles syndrome (MNS) is a rare X-linked dominant 
disorder affecting the skeletal system and connective tissue. To date, <70 
cases with MNS have been documented. Although few reports in the literature 
have shown that these patients might develop kyphoscoliosis, there is no 
report regarding long-term follow-up of patients with MNS undergo spine 
surgery. The aim of this study is to describe 2 unique cases of MNS with 
long-term follow-up after instrumented posterior spinal fusion, 
multiple-level Ponte osteotomies, and pedicle subtraction osteotomies. 
METHODS:: A 17-year-old female patient (patient 1) was evaluated for the 
first time at our institution. She was diagnosed with MNS, severe 
kyphoscoliosis, and restrictive lung disease. After pulmonary function 
improvement, she underwent posterior spinal fusion. Halo-femoral traction 
with gradual weight increase was used a week before spinal surgery. Surgical 
correction of her spinal deformity was achieved through a hooks-and-wires 
construct. The second patient was an 18-year-old female (patient 2) who 
carried the diagnosis of MNS when she was first seen at our institution. She 
had a significant thoracolumbar junction kyphosis and gibbous. She also 
suffered from significant pulmonary disease with a stent in her right main 
stem bronchus. A posterior procedure consisting of multiple-level Ponte 
osteotomies and pedicle subtraction osteotomy at L2 was carried out. 
RESULTS:: Eight- and 5-year follow-up of patients 1 and 2, respectively, 
demonstrated solid fusion, a well-maintained correction, and no evidence of 
implant breakage. CONCLUSIONS:: The reported cases add to the literature of 
excellent long-term results of spinal deformity correction with instrumented 
posterior spinal fusion in patients with MNS. Patients with this condition 
should be closely monitored from early childhood for the development of 
spine deformity so that early referral to a spine surgeon can be made 
followed by appropriate treatment, if necessary. Copyright © 2013 by 
Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone dysplasia; melnick- eedles syndrome; spine malformation (surgery, therapy); X chromosome linked disorder; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; allograft; article; body weight gain; breathing disorder; case report; chronic respiratory failure; Crohn disease; death; disease severity; female; follow up; gastroesophageal reflux; human; hydronephrosis; intubation; kyphoscoliosis; kyphosis; limb deformity; lung disease; osteotomy; physical examination; priority journal; sleep disordered breathing; spine fusion; spine radiography; spine surgery; stone formation; surgery; thoracolumbar spine; thorax deformity; tracheostomy; tracheostomy tube; traction therapy; treatment outcome; treatment response; upper respiratory tract obstruction; valgus knee; ventilator; 
EMBASE CLASSIFICATIONS
  Human Genetics (22)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013110535
MEDLINE PMID
  23389572 (http://www.ncbi.nlm.nih.gov/pubmed/23389572)
PUI
  L368338303
DOI
  10.1097/BPO.0b013e3182776edb
FULL TEXT LINK
  http://dx.doi.org/10.1097/BPO.0b013e3182776edb
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02716798&id=doi:10.1097%2FBPO.0b013e3182776edb&atitle=Correction+of+spine+deformity+in+patients+with+melnick-needles+syndrome%3A+Report+of+2+cases+and+literature+review&stitle=J.+Pediatr.+Orthop.&title=Journal+of+Pediatric+Orthopaedics&volume=33&issue=2&spage=170&epage=174&aulast=Lykissas&aufirst=Marios+G.&auinit=M.G.&aufull=Lykissas+M.G.&coden=JPORD&isbn=&pages=170-174&date=2013&auinit1=M&auinitm=G
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 541
TITLE
  Descending necrotizing mediastinitis associated with spinal cord abscess
AUTHOR NAMES
  Dajer-Fadel W.L.; Borrego-Borrego R.; Flores-Calderón O.; Argüero-Sánchez R.; Navarro-Reynoso F.P.; Ibarra-Pérez C.
AUTHOR ADDRESSES
  (Dajer-Fadel W.L., wadafa@hotmail.com; Borrego-Borrego R.; Flores-Calderón 
O.; Argüero-Sánchez R.; Navarro-Reynoso F.P.; Ibarra-Pérez C.) Department of 
Cardiothoracic Surgery, General Hospital of Mexico, Apartamento 102, Ave. 
Cuauhtemoc 403 edificio 12, Col. Roma Sur, Delegacion Cuauhtemoc, DF, C.P. 
06760, Mexico.
CORRESPONDENCE ADDRESS
  W.L. Dajer-Fadel, Department of Cardiothoracic Surgery, General Hospital of 
Mexico, Apartamento 102, Ave. Cuauhtemoc 403 edificio 12, Col. Roma Sur, 
Delegacion Cuauhtemoc, DF, C.P. 06760, Mexico. Email: wadafa@hotmail.com
AiP/IP ENTRY DATE
  2013-05-23
FULL RECORD ENTRY DATE
  2013-05-30
SOURCE
  Asian Cardiovascular and Thoracic Annals (2013) 21:1 (90-92). Date of 
Publication: February 2013
VOLUME
  21
ISSUE
  1
FIRST PAGE
  90
LAST PAGE
  92
DATE OF PUBLICATION
  February 2013
ISSN
  0218-4923
  1816-5370 (electronic)
BOOK PUBLISHER
  SAGE Publications Inc., 2455 Teller Road, Thousand Oaks, United States.
ABSTRACT
  A 58-year-old man with a history of Ludwig's angina was admitted with a 
spinal cord abscess at the level of C2-T1 and associated osteomyelitic 
destruction of vertebral bodies, spinal cord compression, and secondary 
quadriparesis, followed by descending mediastinitis. A right posterolateral 
thoracotomy and a cervicotomy drained purulent exudates. A tracheostomy was 
performed, and the patient was discharged after 84 days. © The Author(s) 
2012.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  descending necrotizing mediastinitis (surgery); mediastinitis (surgery); spinal cord abscess (surgery); spinal cord disease (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; cervicotomy; computer assisted tomography; human; Ludwig angina; male; quadriplegia; spinal cord compression; spine surgery; spondylolisthesis; thoracotomy; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013310103
MEDLINE PMID
  23430432 (http://www.ncbi.nlm.nih.gov/pubmed/23430432)
PUI
  L368922365
DOI
  10.1177/0218492312449823
FULL TEXT LINK
  http://dx.doi.org/10.1177/0218492312449823
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02184923&id=doi:10.1177%2F0218492312449823&atitle=Descending+necrotizing+mediastinitis+associated+with+spinal+cord+abscess&stitle=Asian+Cardiovasc.+Thorac.+Ann.&title=Asian+Cardiovascular+and+Thoracic+Annals&volume=21&issue=1&spage=90&epage=92&aulast=Dajer-Fadel&aufirst=Walid+Leonardo&auinit=W.L.&aufull=Dajer-Fadel+W.L.&coden=ACTAF&isbn=&pages=90-92&date=2013&auinit1=W&auinitm=L
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 542
TITLE
  West nile virus encephalitis
AUTHOR NAMES
  Prabhakar A.; Coleman R.; Kemp N.; Engel L.S.; DeBoisblanc B.
AUTHOR ADDRESSES
  (Prabhakar A.; Coleman R.; Kemp N.; Engel L.S.; DeBoisblanc B.) LSU Health 
Sciences Center, New Orleans, United States.
CORRESPONDENCE ADDRESS
  A. Prabhakar, LSU Health Sciences Center, New Orleans, United States.
FULL RECORD ENTRY DATE
  2013-02-21
SOURCE
  Journal of Investigative Medicine (2013) 61:2 (415). Date of Publication: 
February 2013
VOLUME
  61
ISSUE
  2
FIRST PAGE
  415
DATE OF PUBLICATION
  February 2013
CONFERENCE NAME
  American Federation for Medical Research Southern Regional Meeting, AFMR 
2013
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2013-02-21 to 2013-02-23
ISSN
  1081-5589
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Case Report: Introduction: The prevalence of West Nile virus (WNV) in the 
continental United States has greatly increased. Manifestations of the virus 
range from asymptomatic carriers to rapidly progressive neurological and 
muscular decline. Case: A 40 year old male with no past medical history 
presented to a rural emergency department with a 3 day history of acute 
onset headache, severe neck pain, fever, drowsiness, weakness, and poor PO 
intake. A lumbar puncture was performed and treatment with vancomycin, 
ceftriaxone, and acyclovir was begun. Initial cerebrospinal fluid (CSF) 
studies were significant for an elevated WBC with predominance of segmented 
neutrophils, elevated protein, and normal glucose. CSF was also sent forWest 
Nile and EBV studies. The patient was subsequently transferred to another 
facility for further neurological evaluation. Notable physical exam findings 
upon presentation were fever of 102 oF, normal sensation throughout, and 
decreased upper extremity motor strength bilaterally. Magnetic resonance 
imaging (MRI) of the cervical and thoracic spine was significant for 
inflammatory myelopathy. MRI of brain was unremarkable. The patient's 
symptoms progressively worsened over the course of 2 days with continued 
neuromuscular decline and weakness coupled with symmetric loss of reflexes. 
The patient was subsequently intubated secondary to impending respiratory 
failure. EMG findings were consistent with Guillain-Barre syndrome Miller 
Fisher variant. The patient was initiated on IVIG treatment. Eight days 
after his initial presentation, his serum IgM was found to be positive for 
WNV. The patient had a long and protracted hospital course with particular 
difficulty being weaned from the ventilator. One and a half months after his 
initial presentation, the patient was discharged with a tracheotomy to an 
outside center to continue his neuromuscular rehabilitation. Discussion: 
West Nile virus is a single stranded RNA virus that was first documented in 
the United States in 1999. Neuroinvasive disease is extremely rare among 
individuals less than 65 years old. This case illustrates that there remains 
a certain amount of unpredictability with WNV disease progression and 
severity and it is important to recognize WNV in a patient's differential 
diagnosis, particularly in areas with higher prevalence.
EMTREE DRUG INDEX TERMS
  aciclovir; ceftriaxone; glucose; immunoglobulin M; protein; RNA; single stranded RNA; vancomycin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  medical research; virus encephalitis; West Nile virus; 
EMTREE MEDICAL INDEX TERMS
  arm; brain; case report; cerebrospinal fluid; differential diagnosis; disease course; drowsiness; electromyogram; emergency ward; fever; Guillain Barre syndrome; headache; hospital; human; lumbar puncture; male; medical history; neck pain; neutrophil; nuclear magnetic resonance imaging; patient; prevalence; reflex; rehabilitation; respiratory failure; RNA virus; sensation; serum; spinal cord disease; thoracic spine; tracheotomy; United States; ventilator; virus; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70993084
DOI
  10.231/JIM.0b013e3182820c55
FULL TEXT LINK
  http://dx.doi.org/10.231/JIM.0b013e3182820c55
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10815589&id=doi:10.231%2FJIM.0b013e3182820c55&atitle=West+nile+virus+encephalitis&stitle=J.+Invest.+Med.&title=Journal+of+Investigative+Medicine&volume=61&issue=2&spage=415&epage=&aulast=Prabhakar&aufirst=A.&auinit=A.&aufull=Prabhakar+A.&coden=&isbn=&pages=415-&date=2013&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 543
TITLE
  Noninvasive respiratory management and diaphragm and electrophrenic pacing 
in neuromuscular disease and spinal cord injury
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu) Department of Physical Medicine and 
Rehabilitation, University of Medicine and Dentistry of New Jersey (UMDNJ), 
B403, 150 Bergen Street, Newark, NJ 07103, United States.
(Bach J.R., bachjr@umdnj.edu) Department of Neurosciences, UMDNJ, Newark, 
NJ, United States.
(Bach J.R., bachjr@umdnj.edu) Center for Ventilator Management Alternatives, 
University Hospital, Newark, NJ, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine and Rehabilitation, University of 
Medicine and Dentistry of New Jersey (UMDNJ), B403, 150 Bergen Street, 
Newark, NJ 07103, United States. Email: bachjr@umdnj.edu
AiP/IP ENTRY DATE
  2013-02-06
FULL RECORD ENTRY DATE
  2013-02-15
SOURCE
  Muscle and Nerve (2013) 47:2 (297-305). Date of Publication: February 2013
VOLUME
  47
ISSUE
  2
FIRST PAGE
  297
LAST PAGE
  305
DATE OF PUBLICATION
  February 2013
ISSN
  0148-639X
  1097-4598 (electronic)
BOOK PUBLISHER
  Wiley Blackwell, 2200 Wilson Blvd, Suite 600, Arlington, United States.
ABSTRACT
  The purpose of this monograph is to describe noninvasive management of 
respiratory muscle weakness/paralysis for patients with neuromuscular 
disease (NMD) and spinal cord injury (SCI). Noninvasive ventilation (NIV) 
assists and supports inspiratory muscles, whereas mechanically assisted 
coughing (MAC) simulates an effective cough. Long-term outcomes will be 
reviewed as well as the use of NIV, MAC, and electrophrenic pacing (EPP) and 
diaphragm pacing (DP) to facilitate extubation and decannulation. Although 
EPP and DP can facilitate decannulation and maintain alveolar ventilation 
for high-level SCI patients when they cannot use NIV because of lack of 
access to oral interfaces, there is no evidence that they have any place in 
the management of NMD. © 2012 Wiley Periodicals, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  assisted ventilation; diaphragm paralysis (therapy); neuromuscular disease (therapy); non invasive procedure; spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  active circuit ventilation; article; artificial ventilation; electrophrenic pacing; electrotherapy; extubation; human; intensive care; intermittent abdominal pressure ventilator; lung function test; mechanical stimulation; mechanically assisted coughing; noninvasive positive pressure mechanical ventilation; noninvasive ventilation; outcome assessment; phrenic nerve pacing; positive end expiratory pressure; pressure control ventilation; priority journal; proportion Assist ventilation; synchronized intermittent mandatory ventilation; volume control ventilation; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013071228
MEDLINE PMID
  23349084 (http://www.ncbi.nlm.nih.gov/pubmed/23349084)
PUI
  L368211455
DOI
  10.1002/mus.23646
FULL TEXT LINK
  http://dx.doi.org/10.1002/mus.23646
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0148639X&id=doi:10.1002%2Fmus.23646&atitle=Noninvasive+respiratory+management+and+diaphragm+and+electrophrenic+pacing+in+neuromuscular+disease+and+spinal+cord+injury&stitle=Muscle+Nerve&title=Muscle+and+Nerve&volume=47&issue=2&spage=297&epage=305&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=MUNED&isbn=&pages=297-305&date=2013&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 544
TITLE
  Initiating chemotherapy in the ICU: Beneficence or maleficence?
AUTHOR NAMES
  Maronge G.F.; Zacharia G.; Puligothram S.; Narmala S.K.
AUTHOR ADDRESSES
  (Maronge G.F.; Zacharia G.; Puligothram S.; Narmala S.K.) LSU Health 
Sciences Center, New Orleans, United States.
CORRESPONDENCE ADDRESS
  G.F. Maronge, LSU Health Sciences Center, New Orleans, United States.
FULL RECORD ENTRY DATE
  2013-02-21
SOURCE
  Journal of Investigative Medicine (2013) 61:2 (466-467). Date of 
Publication: February 2013
VOLUME
  61
ISSUE
  2
FIRST PAGE
  466
LAST PAGE
  467
DATE OF PUBLICATION
  February 2013
CONFERENCE NAME
  American Federation for Medical Research Southern Regional Meeting, AFMR 
2013
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2013-02-21 to 2013-02-23
ISSN
  1081-5589
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Case Report: Case: A thirty-seven year old woman presented to the emergency 
department (ED) at an outside facility with complaint of shortness of breath 
and back pain. She reported the back pain had started 6 months ago and also 
reported 2 weeks of abdominal pain. MRI performed in the ED was concerning 
for spinal cord compression and she was transferred to University Hospital 
in New Orleans. On arrival, she quickly decompensated and was intubated for 
respiratory failure and hypotension. CT of the chest showed a large 
pericardial effusion and multiple bone metastasis to the vertebra, bilateral 
humeri and clavicles. Transthoracic echo demonstrated evidence of cardiac 
tamponade and pericardiocentesis revealed serosanguinous fluid, with 
cytology positive for ovarian adenocarcinoma. CT of the abdomen confirmed 
this diagnosis, showing a 16.7cm × 18.7cm mass arising from the left adnexa. 
The oncology service was consulted by the ICU team to discuss the prognosis 
with the patient's family. Respiratory failure was her only organ failure at 
that time and the team elected to start treatment. She received one cycle of 
chemotherapy and the patient remained intubated and managed by the ICU team. 
On day 7 after chemo, the medical oncology team noted that an aggressive 
sedation and ventilation weaning approach was not in place. Though this 
would normally be employed in a young and healthy patient, this had not been 
implemented due to an assumed poor prognosis. The patient underwent weaning 
and did require tracheostomy 1 week later, however this was decannulized 
approximately nine days after that. The patient was discharged at that time, 
ambulating independently and performing all ADL's. She received her second 
cycle of chemo before hospital discharge and followed-up in the clinic three 
weeks later feeling well except fatigue. Discussion: This case underscores 
the importance of good communication among specialties, being a patient 
advocate, and using evidence based medicine and objective measures when 
available in treatment decisions of cancer patients. This patient was a 
young healthy person with no prior medical problems and no signs of organ 
failure except respiratory failure. Due to aggressive treatment in the ICU, 
she was able to enjoy prolonged survival with preserved quality of life.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  beneficence; chemotherapy; medical research; 
EMTREE MEDICAL INDEX TERMS
  abdomen; abdominal pain; air conditioning; backache; bone metastasis; cancer patient; case report; clavicle; cytology; diagnosis; dyspnea; emergency ward; evidence based medicine; fatigue; female; heart tamponade; hospital; hospital discharge; human; humerus; hypotension; interpersonal communication; liquid; normal human; nuclear magnetic resonance imaging; oncology; ovary adenocarcinoma; patient; pericardial effusion; pericardiocentesis; prognosis; quality of life; respiratory failure; sedation; spinal cord compression; survival; thorax; tracheostomy; United States; university hospital; vertebra; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70993264
DOI
  10.231/JIM.0b013e3182820c55
FULL TEXT LINK
  http://dx.doi.org/10.231/JIM.0b013e3182820c55
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10815589&id=doi:10.231%2FJIM.0b013e3182820c55&atitle=Initiating+chemotherapy+in+the+ICU%3A+Beneficence+or+maleficence%3F&stitle=J.+Invest.+Med.&title=Journal+of+Investigative+Medicine&volume=61&issue=2&spage=466&epage=467&aulast=Maronge&aufirst=G.F.&auinit=G.F.&aufull=Maronge+G.F.&coden=&isbn=&pages=466-467&date=2013&auinit1=G&auinitm=F
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 545
TITLE
  Gaze-controlled, computer-assistedcommunication in Intensive Care Unit: 
S"peaking through the eyes"
AUTHOR NAMES
  Maringelli F.; Brienza N.; Scorrano F.; Grasso F.; Gregoretti C.
AUTHOR ADDRESSES
  (Maringelli F., fmaringelli@gvmnet.it) Anthea Hospital, GVM Care and 
Research, Bari, Italy.
(Maringelli F., fmaringelli@gvmnet.it) Città di Lecce Hospital, GVM Care and 
Research, Lecce, Italy.
(Brienza N.) Intensive Care Unit, Department of Emergency and Organ 
Transplantation, University Aldo Moro, Bari, Italy.
(Scorrano F.; Grasso F.) Intensive Care Unit, V. Fazzi Hospital, Lecce, 
Italy.
(Gregoretti C.) Department of Emergency, M. Adelaide Hospital, Turin, Italy.
CORRESPONDENCE ADDRESS
  F. Maringelli, Anthea Hospital, GVM Care and Research, Bari, Italy. Email: 
fmaringelli@gvmnet.it
AiP/IP ENTRY DATE
  2013-04-24
FULL RECORD ENTRY DATE
  2013-04-30
SOURCE
  Minerva Anestesiologica (2013) 79:2 (165-175). Date of Publication: February 
2013
VOLUME
  79
ISSUE
  2
FIRST PAGE
  165
LAST PAGE
  175
DATE OF PUBLICATION
  February 2013
ISSN
  0375-9393
BOOK PUBLISHER
  Edizioni Minerva Medica, Corso Bramante 83-85, Torino, Italy.
ABSTRACT
  Background. The aim of this study was to test the hypothesis that a 
gaze-controlled communication system (eye tracker, ET) can improve 
communication processes between completely dysarthric ICU patients and the 
hospital staff, in three main domains: 1) basic communication processes 
(i.e., fundamental needs, desire, and wishes); 2) the ability of the medical 
staff to understand the clinical condition of the patient; and 3) the level 
of frustration experienced by patient, nurses and physicians. Methods. 
Fifteen fully conscious medical and surgical patients, 8 physicians, and 15 
nurses were included in the study. The experimental procedure was composed 
by three phases: in phase 1 all groups completed the preintervention 
questionnaire; in phase 2 the ET was introduced and tested as a 
communication device; in phase 3 all groups completed the postintervention 
questionnaire. Results. Patients preintervention questionnaires showed 
remarkable communication deficits, without any group effect. Answers of 
physicians and nurses were pretty much similar to the one of patients. 
Postintervention questionnaires showed in all groups a remarkable and 
statistically significant improvement in different communication domains, as 
well as a remarkable decrease of anxiety and disphoric thought. Improvement 
was also reported by physicians and nurses in their ability to understand 
patients clinical conditions. Conclusion. Our results show an improvement in 
the quality of the examined parameters. Better communication processes seem 
also to lead to improvements in several psychological parameters, namely 
anxiety and drop-out depression perceived by both patients and medical 
staff. Further controlled studies are needed to define the ET role in ICU.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  computer assisted communication; data processing; gaze; intensive care unit; interpersonal communication; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; amyotrophic lateral sclerosis; anxiety; article; artificial ventilation; basic needs; chronic obstructive lung disease; clinical article; comprehension; computer; dysarthria; dysphonia; endotracheal intubation; female; frustration; hospital patient; human; male; medical staff; nurse; physician; questionnaire; spinal cord injury; tracheostomy; 
EMBASE CLASSIFICATIONS
  Ophthalmology (12)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013239032
MEDLINE PMID
  23174919 (http://www.ncbi.nlm.nih.gov/pubmed/23174919)
PUI
  L368728213
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03759393&id=doi:&atitle=Gaze-controlled%2C+computer-assistedcommunication+in+Intensive+Care+Unit%3A+S%22peaking+through+the+eyes%22&stitle=Minerva+Anestesiol.&title=Minerva+Anestesiologica&volume=79&issue=2&spage=165&epage=175&aulast=Maringelli&aufirst=F.&auinit=F.&aufull=Maringelli+F.&coden=MIANA&isbn=&pages=165-175&date=2013&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 546
TITLE
  Clinical characteristics and early effective treatment for pulmonary 
infection after acute cervical spinal cord injury
AUTHOR NAMES
  Xu G.-H.; Zhang Y.; Man Y.; Jia L.-S.
AUTHOR ADDRESSES
  (Xu G.-H.; Zhang Y.; Man Y.) Department of Orthopedics, Zhabei Branch, 
Changzheng Hospital, Shanghai 200070, China.
(Jia L.-S., jialianshun@163.com) Department of Orthopedics, Changzheng 
Hospital, Second Military Medical University, Shanghai 200003, China.
CORRESPONDENCE ADDRESS
  L.-S. Jia, Department of Orthopedics, Changzheng Hospital, Second Military 
Medical University, Shanghai 200003, China. Email: jialianshun@163.com
AiP/IP ENTRY DATE
  2013-03-06
FULL RECORD ENTRY DATE
  2013-04-03
SOURCE
  National Medical Journal of China (2013) 93:5 (352-356). Date of 
Publication: 29 Jan 2013
VOLUME
  93
ISSUE
  5
FIRST PAGE
  352
LAST PAGE
  356
DATE OF PUBLICATION
  29 Jan 2013
ISSN
  0376-2491
BOOK PUBLISHER
  Chinese Medical Association, 42 Dongsi Xidajie, Beijing, China.
ABSTRACT
  Objective: To explore the clinical characteristics and early effective 
treatment for pulmonary infection after acute cervical spinal cord injury. 
Methods: A total of 215 inpatients with acute cervical spinal cord injury 
were retrospectively analyzed. Their chest radiological films and blood 
profiles at discharge were analyzed. The fourth generation cephalosporin was 
used to treat pulmonary infection as soon as admission and the antibiotics 
switched according to the results of sputum culture and drug sensitive test. 
Incision of trachea was performed and breath supported by breath machine 
according to respiratory condition and blood gas analysis. All patients were 
turned over and slapped on the back in order to excrete phlegm in time. 
Sometimes bronchial lavage was used to excrete phlegm. The chest 
radiological examinations and sputum culture were performed twice one week. 
Once fungal infection was definite, specific antibiotic was used to treat 
infection. Three-liter bas and nasal-feeding were used to improve the 
nutrition condition. Incision of trachea was closed as soon as possible. 
Results: Pulmonary infection of 214 patients was finally cured. Among them, 
43 suffered from pulmonary closure. One patient died from severe infection 
of Klebsiella pneumoniae. Pulmonary infection appeared upon admission and 
was mostly accompanied with hyperpyrexia. The result of sputum culture 
revealed baumanii and the pathogen of hemoculture was Pseudomonas 
aeruginosa. At 3-4 weeks later, mycotic infection appeared. And 17 patients 
suffered from Klebsiella pneumoniae and one died. Conclusion: Pulmonary 
infection after acute cervical spinal cord injury is severe and occurs 
early. Effective antibiotics according to the result of sputum culture, 
turnover & back-slapping for excreting phlegm in time, expectoration 
training and strengthening overall nutrition are effective therapeutic 
measures. Copyright © 2013 by the Chinese Medical Association.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); cephalosporin derivative (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; lung infection (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  antibiotic sensitivity; antibiotic therapy; article; blood gas analysis; blood sampling; hospital admission; human; hyperpyrexia; Klebsiella pneumoniae; Klebsiella pneumoniae infection; major clinical study; Pseudomonas aeruginosa; retrospective study; sputum culture; thorax radiography; trachea; tracheobronchial toilet; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  Chinese, English
EMBASE ACCESSION NUMBER
  2013130184
MEDLINE PMID
  23660207 (http://www.ncbi.nlm.nih.gov/pubmed/23660207)
PUI
  L368415739
DOI
  10.3760/cma.j.issn.0376-2491.2013.05.008
FULL TEXT LINK
  http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2013.05.008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03762491&id=doi:10.3760%2Fcma.j.issn.0376-2491.2013.05.008&atitle=Clinical+characteristics+and+early+effective+treatment+for+pulmonary+infection+after+acute+cervical+spinal+cord+injury&stitle=Nat.+Med.+J.+China&title=National+Medical+Journal+of+China&volume=93&issue=5&spage=352&epage=356&aulast=Xu&aufirst=Guang-Hui&auinit=G.-H.&aufull=Xu+G.-H.&coden=&isbn=&pages=352-356&date=2013&auinit1=G&auinitm=-H
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 547
TITLE
  An update on pediatric diaphragm pacing: What we learned and how diaphragm 
pacing is an excellent option in pediatric spinal cord injured patients
AUTHOR NAMES
  Elmo M.J.
AUTHOR ADDRESSES
  (Elmo M.J.)
CORRESPONDENCE ADDRESS
  M.J. Elmo,
FULL RECORD ENTRY DATE
  2013-05-23
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2013) 19:2 (153). Date of 
Publication: Spring 2013
VOLUME
  19
ISSUE
  2
FIRST PAGE
  153
DATE OF PUBLICATION
  Spring 2013
CONFERENCE NAME
  2012 Howard H. Steel Conference on Pediatric Spinal Cord Injury and 
Dysfunction
CONFERENCE LOCATION
  Lake Buena Vista, FL, United States
CONFERENCE DATE
  2012-11-29 to 2012-12-01
ISSN
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc.
ABSTRACT
  Diaphragm pacing is a viable breathing option in pediatric SCI. This is an 
update of pediatric diaphragm pacing at one institution highlighting the 
differences between children and adults. Background: Diaphragm pacing (DP) 
has successfully replaced or decreased tracheostomy mechanical ventilation 
(TMV) in adult SCI. The incidence of cervical cord injuries is 
disproportionately high in young children. The success of DP in the 
pediatric patient has been previously described. This report will summarize 
all pediatric patients implanted at one institution highlighting the 
differences in surgical implantation and diaphragm condition among the age 
groups. Methods: Retrospective review of all implanted pediatric DP 
patients. Results: A total of 11 patients between ages of 27 months and 17 
years were implanted between January 2009 and May 2012. Additionally at 
operative exploration, 2 patients unexpectedly had denervated diaphragms and 
were not implanted. Four patients were between 2-3 years old, 2 were 5 years 
old, 4 patients were between 9-10 years, and 1 was 17 years old. The average 
time spent on TMV was 31.65 months with a range of 11 days to 91 months. 
Over 50% (6) of patients achieved full time pacing. Three patients are off 
the ventilator for 12-16 hours daily while the others are still in the 
conditioning phase. One patient, from the possible neuroplasticity effects 
of functional electrical stimulation, regained full volitional breathing 
with easy removal of the wires. No patients had perioperative or 
postoperative complications. To date, there are no long-term complications. 
The 2 patients implanted early post injury went directly to full time 
pacing. Scoliosis and use of a hard shell back brace can affect pacing. 
Children ages 4-5 and those on TMV greater than 5 years have the most 
anxiety with pacing. Utilizing the pacer simultaneously with TMV can lead to 
severe hypocapnia. As little as 15-20 minutes of pacing time daily can 
significantly improve lung compliance affecting tidal volumes when using 
pressure control mode. Parents report improvement in freedom, independence, 
mobility, and activity with pacing. Conclusions: Early diaphragm pacing is 
the optimal utilization and may help with functional recovery. In the 2- to 
3-year-olds, the major obstacle to pacing is habituating to the change in 
sensation. In the 5- to 10-year-olds, the major obstacle to pacing is fear. 
Early implantation decreases conditioning times. Pacing improves quality of 
life.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  steel; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm; human; patient; spinal cord; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; anxiety; artificial ventilation; brace; breathing; cervical spinal cord injury; child; conditioning; denervation; fear; functional electrical stimulation; groups by age; hypocapnia; implantation; independence; injury; lung compliance; nerve cell plasticity; parent; postoperative complication; quality of life; scoliosis; sensation; tidal volume; Tobacco mosaic virus; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71061521
DOI
  10.1310/sci1902-152
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci1902-152
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci1902-152&atitle=An+update+on+pediatric+diaphragm+pacing%3A+What+we+learned+and+how+diaphragm+pacing+is+an+excellent+option+in+pediatric+spinal+cord+injured+patients&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=19&issue=2&spage=153&epage=&aulast=Elmo&aufirst=Mary+Jo&auinit=M.J.&aufull=Elmo+M.J.&coden=&isbn=&pages=153-&date=2013&auinit1=M&auinitm=J
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 548
TITLE
  Management of spinal trauma in emergency department
AUTHOR NAMES
  Akdemir H.U.; Kati C.; Duran L.; Kuruoǧlu E.
AUTHOR ADDRESSES
  (Akdemir H.U., hufukakdemir@hotmail.com; Kati C.; Duran L.) Department of 
Emergency Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun, 
Turkey.
(Kuruoǧlu E.) Department of Neurosurgery, Faculty of Medicine, Ondokuz Mayis 
University, Samsun, Turkey.
CORRESPONDENCE ADDRESS
  H.U. Akdemir, Department of Emergency Medicine, Faculty of Medicine, Ondokuz 
Mayis University, Samsun, Turkey. Email: hufukakdemir@hotmail.com
AiP/IP ENTRY DATE
  2014-06-04
FULL RECORD ENTRY DATE
  2014-06-12
SOURCE
  Journal of Experimental and Clinical Medicine (Turkey) (2013) 30:4 
(285-289). Date of Publication: December 2013
VOLUME
  30
ISSUE
  4
FIRST PAGE
  285
LAST PAGE
  289
DATE OF PUBLICATION
  December 2013
ISSN
  1309-4483
BOOK PUBLISHER
  Ondokuz Mayis Universitesi, Samsun, Turkey.
ABSTRACT
  Spinal cord injuries are traumatic incidents which lead to serious clinical 
consequences and affect the lives of individuals and their families. Despite 
all medical and surgical advances, optimal treatment still remains a serious 
clinical problem. It is mostly not possible to prevent the primary injury 
arising from trauma exposure in spite of all measures taken. However, some 
biochemical events developing in spinal cord following the primary injury 
cause more damage to the cord. This process also defined as the secondary 
injury increases the importance of emergency department approach to patients 
with acute spinal trauma. Emergency department practices in spinal cord 
injuries are extremely important in terms of both primary care and 
prevention of complications. © 2013 OMU.
EMTREE DRUG INDEX TERMS
  dobutamine (drug therapy); dopamine (drug therapy); methylprednisolone (drug therapy); oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency care; patient care; spinal cord injury (drug therapy, diagnosis, drug therapy, therapy); 
EMTREE MEDICAL INDEX TERMS
  acute disease (diagnosis); anogenital reflex; anus sphincter; assisted ventilation; bleeding disorder (complication); cervical collar; cervical spinal cord injury (therapy); cervical spine; cervical spine radiography; clinical examination; clinical trial (topic); computed tomography scanner; computer assisted tomography; decubitus (complication); disease classification; early diagnosis; echography; emergency ward; endotracheal intubation; endotracheal tube; epidural hematoma (diagnosis); human; hypotension (complication, drug therapy); immobilization; nasotracheal intubation; neurologic examination; nuclear magnetic resonance imaging; oropharynx airway; oxygen mask; oxygen nasal cannula; oxygen saturation; oxygenation; peritoneum lavage; proprioception; pulmonary artery occlusion pressure; pulse oximetry; reflex; respiratory care; respiratory tract disease (surgery, therapy); review; spine radiography; spine stabilization; steroid therapy; subdural hematoma (diagnosis); Swan Ganz catheter; tendon reflex; thoracolumbar spine; thoracolumbar spine radiography; tracheotomy; treatment planning; vibration sense; 
CAS REGISTRY NUMBERS
  dobutamine (34368-04-2, 52663-81-7, 49745-95-1, 61661-06-1)
  dopamine (51-61-6, 62-31-7)
  methylprednisolone (6923-42-8, 83-43-2)
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014359055
PUI
  L373160152
DOI
  10.5835/jecm.omu.30.04.001
FULL TEXT LINK
  http://dx.doi.org/10.5835/jecm.omu.30.04.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13094483&id=doi:10.5835%2Fjecm.omu.30.04.001&atitle=Management+of+spinal+trauma+in+emergency+department&stitle=J.+Exp.+Clin.+Med.&title=Journal+of+Experimental+and+Clinical+Medicine+%28Turkey%29&volume=30&issue=4&spage=285&epage=289&aulast=Akdemir&aufirst=Hizir+Ufuk&auinit=H.U.&aufull=Akdemir+H.U.&coden=&isbn=&pages=285-289&date=2013&auinit1=H&auinitm=U
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 549
TITLE
  Benefit, timing, and technique of tracheostomy
AUTHOR NAMES
  Lissauer M.E.
AUTHOR ADDRESSES
  (Lissauer M.E.)
CORRESPONDENCE ADDRESS
  M.E. Lissauer,
AiP/IP ENTRY DATE
  2013-10-31
FULL RECORD ENTRY DATE
  2013-11-21
SOURCE
  Current Problems in Surgery (2013) 50:10 (494-499). Date of Publication: 
October 2013
VOLUME
  50
ISSUE
  10
FIRST PAGE
  494
LAST PAGE
  499
DATE OF PUBLICATION
  October 2013
ISSN
  1535-6337 (electronic)
  0011-3840
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  airway obstruction (therapy); article; artificial ventilation; brain injury; bronchoscope; cost; endotracheal intubation; guide wire; heart arrest (complication); human; intensive care unit; length of stay; mortality; randomized controlled trial (topic); respiratory failure (therapy); risk benefit analysis; spinal cord injury; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013674859
MEDLINE PMID
  24156849 (http://www.ncbi.nlm.nih.gov/pubmed/24156849)
PUI
  L370106872
DOI
  10.1067/j.cpsurg.2013.08.015
FULL TEXT LINK
  http://dx.doi.org/10.1067/j.cpsurg.2013.08.015
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15356337&id=doi:10.1067%2Fj.cpsurg.2013.08.015&atitle=Benefit%2C+timing%2C+and+technique+of+tracheostomy&stitle=Curr.+Probl.+Surg.&title=Current+Problems+in+Surgery&volume=50&issue=10&spage=494&epage=499&aulast=Lissauer&aufirst=Matthew+E.&auinit=M.E.&aufull=Lissauer+M.E.&coden=CPSUA&isbn=&pages=494-499&date=2013&auinit1=M&auinitm=E
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 550
TITLE
  Survey of clinicians experience and attitudes regarding spinal muscular 
atrophy with respiratory distress syndrome type 1 (SMARD1)
AUTHOR NAMES
  Jerrom T.D.; Majumdar A.; Shah S.; Fraser J.
AUTHOR ADDRESSES
  (Jerrom T.D.; Majumdar A.; Shah S.; Fraser J.) Bristol Royal Hospital for 
Children, Bristol, United Kingdom.
CORRESPONDENCE ADDRESS
  T.D. Jerrom, Bristol Royal Hospital for Children, Bristol, United Kingdom.
FULL RECORD ENTRY DATE
  2013-01-17
SOURCE
  Developmental Medicine and Child Neurology (2013) 55 SUPPL. 1 (25-26). Date 
of Publication: January 2013
VOLUME
  55
FIRST PAGE
  25
LAST PAGE
  26
DATE OF PUBLICATION
  January 2013
CONFERENCE NAME
  2013 Annual Meeting of the British Paediatric Neurology Association
CONFERENCE LOCATION
  Manchester, United Kingdom
CONFERENCE DATE
  2013-01-23 to 2013-01-25
ISSN
  0012-1622
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Objectives: In an attempt to help provide more standardised care for 
children with SMARD1 we carried out an online survey in April 2012 to 
investigate clinician's experiences and attitudes regarding treatment of 
SMARD1. Methods: We distributed our survey to 601 Consultants via four 
specialist interest groups based in the UK including the BPNA. The survey 
was broken down into eight questions, including demographic information and 
then a series of ethical and clinical dilemmas. Results: We received 80 
responses (13.3%, n=80/601); 36.3% were Paediatric Neurologists (n=29/80), 
25% Paediatric Intensivists (n=20/80, with the remainder working within 
Neurology, Long Term Ventilation (LTV) or General Paediatrics (total 32.4%, 
n=26/80). When asked 'What treatment plan they would offer the family of a 
3.5 month old child with SMARD1 who is ventilated and has repeatedly failed 
extubation to mask non-invasive ventilation', 47.9% would offer extubation 
followed by palliative care, 14.1% would advocate long term tracheostomy 
home ventilation (LTTHV), and 38% would offer both. Consultants with <10 
years of experience and those who had not previously cared for a child with 
SMARD1 were more likely to recommend extubation followed by palliative care. 
The most commonly cited reasons for not offering children with SMARD1 LTTHV 
were: unacceptably poor quality of life on LTTHV (54.9%, n=39/71), the 
burden of care placed upon carers (42.3%, n=30/71) and assumed short life 
expectancy despite LTTHV (35.2%, n=25/71). 80% (n=8/10) stated categorically 
that diaphragm plication did not improve the child's clinical status or 
ventilator requirements. Conclusion: Our study shows that a minority of 
clinicians would advocate LTTHV for children with SMARD1. Motivating factors 
for decisions are different between different specialties. Less experienced 
clinicians and those with no prior experience of SMARD1 appear to be more 
likely to only offer a palliative approach. Diaphragmatic plication does not 
appear help in the majority of children.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neurology; respiratory distress syndrome; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; child; consultation; diaphragm; extubation; human; life expectancy; medical specialist; neurologist; noninvasive ventilation; palliative therapy; pediatrics; quality of life; tracheostomy; United Kingdom; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70967771
DOI
  10.1111/dmcn.12068
FULL TEXT LINK
  http://dx.doi.org/10.1111/dmcn.12068
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00121622&id=doi:10.1111%2Fdmcn.12068&atitle=Survey+of+clinicians+experience+and+attitudes+regarding+spinal+muscular+atrophy+with+respiratory+distress+syndrome+type+1+%28SMARD1%29&stitle=Dev.+Med.+Child+Neurol.&title=Developmental+Medicine+and+Child+Neurology&volume=55&issue=&spage=25&epage=26&aulast=Jerrom&aufirst=T.D.&auinit=T.D.&aufull=Jerrom+T.D.&coden=&isbn=&pages=25-26&date=2013&auinit1=T&auinitm=D
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 551
TITLE
  Paediatric neuromyelitis optica (NMO) presenting with encephalopathy and 
severe brain lesions
AUTHOR NAMES
  Munasinghe J.; Symmonds M.; Fallon P.
AUTHOR ADDRESSES
  (Munasinghe J.; Fallon P.) Paediatric Neurology, St George's Hospital, 
London, United Kingdom.
(Symmonds M.) Neurology, St George's Hospital, London, United Kingdom.
CORRESPONDENCE ADDRESS
  J. Munasinghe, Paediatric Neurology, St George's Hospital, London, United 
Kingdom.
FULL RECORD ENTRY DATE
  2013-01-17
SOURCE
  Developmental Medicine and Child Neurology (2013) 55 SUPPL. 1 (28-29). Date 
of Publication: January 2013
VOLUME
  55
FIRST PAGE
  28
LAST PAGE
  29
DATE OF PUBLICATION
  January 2013
CONFERENCE NAME
  2013 Annual Meeting of the British Paediatric Neurology Association
CONFERENCE LOCATION
  Manchester, United Kingdom
CONFERENCE DATE
  2013-01-23 to 2013-01-25
ISSN
  0012-1622
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Introduction: Neuromyelitis optica is an uncommon demyelinating central 
nervous system disease characterised by longitudinally extensive transverse 
myelitis (LETM), optic neuritis and Aquaporin 4 (AQP4) seropositivity. 
Encephalopathy and extensive brain lesions are a rare presentation of this 
disease which usually follows a relapsing and remitting course with 
significant disability. Case description: An 11-year-old girl presented 
acutely with airway compromise following 3 weeks of increasing lethargy and 
required prolonged ventilation. She was quadriparetic and had bulbar 
involvement. MRI revealed LETM involving cervicothoracic spine, 
demyelinating lesions in bilateral mesial temporal lobes, left basal 
ganglia, right thalamus, hypothalamus and dorsal medulla. Cerebrospinal 
fluid was acellular with negative oligoclonal bands. EEG showed evidence of 
encephalopathy. AQP4 antibodies were positive. She was initially treated 
with IV methylprednisolone (IVMP) and intravenous immunoglobulin and 
subsequently prednisolone for 6 weeks. She recovered well however retained a 
tracheostomy and required nasogastric feeding. Four months later she 
relapsed with encephalopathy, bilateral abducens palsy and right upper limb 
weakness. MRI showed new lesions in bilateral basal ganglia, right internal 
capsule, right thalamus, midbrain and thoracic spinal cord. She received 
further IVMP, regular plasma exchange and commenced long term prednisolone 
and azathioprine. She went into remission and became seronegative for 
Aquaporin 4 antibodies. There has been no clinical or MRI evidence of optic 
neuritis and VEP was normal. Discussion: This case illustrates that 
paediatric neuromyelitis optica can present with encephalopathy and large 
brain lesions in a similar fashion to acute disseminated encephalomyelitis. 
Optic neuritis may not be present initially. AQP4 antibody is an important 
investigation in such cases to confirm the diagnosis of NMO, as its severe 
clinical sequelae can necessitate timely immunosuppression and plasma 
exchange in addition to steroids.
EMTREE DRUG INDEX TERMS
  antibody; aquaporin 4; aquaporin 4 antibody; azathioprine; immunoglobulin; methylprednisolone; oligoclonal band; prednisolone; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain damage; brain disease; myelooptic neuropathy; neurology; 
EMTREE MEDICAL INDEX TERMS
  abducens nerve paralysis; acute disseminated encephalomyelitis; air conditioning; airway; arm; basal ganglion; capsula interna; central nervous system disease; cerebrospinal fluid; diagnosis; disability; electroencephalogram; female; girl; human; hypothalamus; immunosuppressive treatment; lethargy; limb weakness; mesencephalon; myelitis; nose feeding; nuclear magnetic resonance imaging; optic neuritis; plasmapheresis; remission; spine; temporal lobe; thalamus; thoracic spinal cord; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70967777
DOI
  10.1111/dmcn.12068
FULL TEXT LINK
  http://dx.doi.org/10.1111/dmcn.12068
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00121622&id=doi:10.1111%2Fdmcn.12068&atitle=Paediatric+neuromyelitis+optica+%28NMO%29+presenting+with+encephalopathy+and+severe+brain+lesions&stitle=Dev.+Med.+Child+Neurol.&title=Developmental+Medicine+and+Child+Neurology&volume=55&issue=&spage=28&epage=29&aulast=Munasinghe&aufirst=J.&auinit=J.&aufull=Munasinghe+J.&coden=&isbn=&pages=28-29&date=2013&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 552
TITLE
  Home-based overnight transcutaneous capnography/pulse oximetry for 
diagnosing nocturnal hypoventilation associated with neuromuscular disorders
AUTHOR NAMES
  Bauman K.A.; Kurili A.; Schmidt S.L.; Rodriguez G.M.; Chiodo A.E.; Sitrin R.G.
AUTHOR ADDRESSES
  (Bauman K.A., krisbaum@umich.edu; Schmidt S.L.; Sitrin R.G.) Pulmonary and 
Critical Care Medicine Division, Department of Internal Medicine, University 
of Michigan Health System, Ann Arbor, MI, United States.
(Kurili A.) MedEquip Home Care Services, Ann Arbor, MI, United States.
(Rodriguez G.M.; Chiodo A.E.) Department of Physical Medicine and 
Rehabilitation, University of Michigan Health System, Ann Arbor, MI, United 
States.
CORRESPONDENCE ADDRESS
  K.A. Bauman, 3916 Taubman Center, SPC 5360, 1500 E Medical Center Dr., Ann 
Arbor, MI 48109-5360, United States. Email: krisbaum@umich.edu
AiP/IP ENTRY DATE
  2012-10-31
FULL RECORD ENTRY DATE
  2013-01-11
SOURCE
  Archives of Physical Medicine and Rehabilitation (2013) 94:1 (46-52). Date 
of Publication: January 2013
VOLUME
  94
ISSUE
  1
FIRST PAGE
  46
LAST PAGE
  52
DATE OF PUBLICATION
  January 2013
ISSN
  0003-9993
  1532-821X (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Objective: To determine the utility of home-based, unsupervised 
transcutaneous partial pressure of carbon dioxide (tc-Pco(2)) 
monitoring/oxygen saturation by pulse oximetry (Spo(2)) for detecting 
nocturnal hypoventilation (NH) in individuals with neuromuscular disorders. 
Design: Retrospective case series analyzed consecutively. Setting: 
Multidisciplinary neuromuscular respiratory failure (NMRF) clinic at an 
academic institution. Participants: Subjects (N=35, 68.6% men; mean age, 
46.9y) with spinal cord injury (45.7%) or other neuromuscular disorders 
underwent overnight tests with tc-Pco(2)/Spo(2) monitoring. Fifteen (42.9%) 
were using nocturnal ventilatory support, either bilevel positive airway 
pressure (BiPAP) or tracheostomy ventilation (TV). Interventions: A 
respiratory therapist brought a calibrated tc-Pco(2)/Spo(2) monitor to the 
patient's home and provided instructions for data collection during the 
subject's normal sleep period. Forced vital capacity (FVC), body mass index 
(BMI), and exhaled end-tidal Pco(2) (ET-Pco(2)) were recorded at a clinic 
visit before monitoring. Main Outcome Measures: Detection of NH (tc-Pco(2) 
≥50mmHg for ≥5% of monitoring time). Data were also analyzed to determine 
whether nocturnal oxygen desaturation (Spo(2) ≤88% for ≥5% of monitoring 
time), FVC, BMI, or daytime ET-Pco(2) could predict the presence of NH. 
Results: NH was detected in 18 subjects (51.4%), including 53.3% of those 
using BiPAP or TV. NH was detected in 43.8% of ventilator-independent 
subjects with normal daytime ET-Pco(2) (present for 49.4%±31.5% [mean ± SD] 
of the study period), and in 75% of subjects with an elevated daytime 
ET-Pco(2) (present for 92.3%±8.7% of the study period). Oxygen desaturation, 
BMI, and FVC were poor predictors of NH. Only 3 attempted monitoring studies 
failed to produce acceptable results. Conclusions: Home-based, unsupervised 
monitoring with tc-Pco(2)/Spo(2) is a useful method for diagnosing NH in 
NMRF. © 2013 by the American Congress of Rehabilitation Medicine.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  capnometry; home care; hypoventilation (diagnosis); neuromuscular disease; nocturnal hypoventilation (diagnosis); pulse oximetry; transcutaneous carbon dioxide monitoring; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; body mass; clinical article; female; forced vital capacity; human; hypercapnia; male; oxygen desaturation; oxygen saturation; positive end expiratory pressure; retrospective study; sleep; spinal cord injury; tracheostomy; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012753762
MEDLINE PMID
  22964272 (http://www.ncbi.nlm.nih.gov/pubmed/22964272)
PUI
  L52276248
DOI
  10.1016/j.apmr.2012.08.215
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2012.08.215
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2Fj.apmr.2012.08.215&atitle=Home-based+overnight+transcutaneous+capnography%2Fpulse+oximetry+for+diagnosing+nocturnal+hypoventilation+associated+with+neuromuscular+disorders&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=94&issue=1&spage=46&epage=52&aulast=Bauman&aufirst=Kristy+A.&auinit=K.A.&aufull=Bauman+K.A.&coden=APMHA&isbn=&pages=46-52&date=2013&auinit1=K&auinitm=A
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 553
TITLE
  Management of children with spinal muscular atrophy type 1 in Australia
AUTHOR NAMES
  Tassie B.; Isaacs D.; Kilham H.; Kerridge I.
AUTHOR ADDRESSES
  (Tassie B., bentassie@gmail.com; Isaacs D.; Kilham H.; Kerridge I.) Centre 
for Values, Ethics and the Law in Medicine, Medical Foundation Building, K25 
the University of Sydney, NSW 2006, Australia.
(Tassie B., bentassie@gmail.com; Isaacs D.; Kilham H.; Kerridge I.) Sydney 
Medical School, University of Sydney, Sydney, NSW, Australia.
(Isaacs D.) Department of Infectious Diseases and Microbiology, Sydney 
Children's Hospitals Network, Children's Hospital at Westmead, Sydney, NSW, 
Australia.
(Kilham H.) Department of General Medicine, Sydney Children's Hospitals 
Network, Children's Hospital at Westmead, Sydney, NSW, Australia.
(Kerridge I.) Department of Haematology and Transfusion Medicine, Royal 
North Shore Hospital, Sydney, NSW, Australia.
CORRESPONDENCE ADDRESS
  B. Tassie, Centre for Values, Ethics and the Law in Medicine, Medical 
Foundation Building, K25 the University of Sydney, NSW 2006, Australia. 
Email: bentassie@gmail.com
AiP/IP ENTRY DATE
  2013-07-17
FULL RECORD ENTRY DATE
  2013-10-30
SOURCE
  Journal of Paediatrics and Child Health (2013) 49:10 (815-819). Date of 
Publication: October 2013
VOLUME
  49
ISSUE
  10
FIRST PAGE
  815
LAST PAGE
  819
DATE OF PUBLICATION
  October 2013
ISSN
  1440-1754 (electronic)
  1034-4810
BOOK PUBLISHER
  Blackwell Publishing, info@asia.blackpublishing.com.au
ABSTRACT
  Aims The study aims to: (i) estimate the prevalence of spinal muscular 
atrophy type 1 (SMA 1); (ii) describe what practices characterise 
end-of-life care of patients with SMA 1; and (iii) ascertain whether a 
consistent approach to the management of these patients exists in Australia. 
Methods An audit of the Australasian pathology laboratories offering the 
diagnostic SMN1 deletion test was conducted for patients diagnosed with SMA 
in Australia for 2010 and 2011. In addition, a retrospective clinical audit 
was conducted in eight major Australian paediatric hospitals of the 
end-of-life care provided to children with confirmed SMA 1 from 2005 to 
2010. Results Thirty-five children were included in the clinical audit, 
accounting for an estimated 61% of children diagnosed with SMA 1 from 2005 
to 2010. Twenty-six per cent were ventilated invasively, only two of whom 
were intubated after the diagnosis was confirmed. No children were 
ventilated long term (>90 days) or had a tracheostomy performed. Nasogastric 
tube feeding was a common measure to support adequate nutritional intake. 
Total parenteral nutrition, gastrostomy and fundoplication were not provided 
for any children. Conflict over end-of-life care decisions was documented in 
one instance, without the involvement of a guardianship tribunal. Conclusion 
There appears to be a consistent approach in the management of children with 
SMA 1 in Australia, which can be characterised as 'actively managed dying'. 
This study could contribute to the development of Australian consensus 
guidelines for the management of these children. These results also 
highlight a number of ethical issues related to the management of children 
with SMA 1. © 2013 The Authors. Journal of Paediatrics and Child Health.
EMTREE DRUG INDEX TERMS
  survival motor neuron protein 1 (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  article; Australia; child; child care; clinical audit; clinical practice; dietary intake; human; hydration; infant; major clinical study; medical decision making; nose feeding; pediatric hospital; prevalence; priority journal; terminal care; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013668627
MEDLINE PMID
  23834358 (http://www.ncbi.nlm.nih.gov/pubmed/23834358)
PUI
  L52674964
DOI
  10.1111/jpc.12291
FULL TEXT LINK
  http://dx.doi.org/10.1111/jpc.12291
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14401754&id=doi:10.1111%2Fjpc.12291&atitle=Management+of+children+with+spinal+muscular+atrophy+type+1+in+Australia&stitle=J.+Paediatr.+Child+Health&title=Journal+of+Paediatrics+and+Child+Health&volume=49&issue=10&spage=815&epage=819&aulast=Tassie&aufirst=Benjamin&auinit=B.&aufull=Tassie+B.&coden=JPCHE&isbn=&pages=815-819&date=2013&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 554
TITLE
  History of hereditary motor and sensory neuropathy with proximal dominant 
involvement (HMSN-P)
AUTHOR NAMES
  Takashima H.
AUTHOR ADDRESSES
  (Takashima H.) Department of Neurology and Geriatrics, Kagoshima University 
Graduate School of Medical and Dental Sciences
FULL RECORD ENTRY DATE
  2015-04-17
SOURCE
  Rinshō shinkeigaku = Clinical neurology (2013) 23:11 (1196-1198). Date of 
Publication: 2013
VOLUME
  23
ISSUE
  11
FIRST PAGE
  1196
LAST PAGE
  1198
DATE OF PUBLICATION
  2013
ISSN
  1882-0654 (electronic)
ABSTRACT
  We established a new disease autosomal dominant hereditary motor and sensory 
neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, 
Japan. This disease is characterized by proximal dominant neurogenic atrophy 
with fasciculations, painful muscle cramp, obvious sensory nerve 
involvement, areflexia, high incidence of elevated creatine kinase levels, 
hyperlipidemia and hyperglycemia. (MIM %604484). HMSNP is so called or HMSNO 
(HMSN OKINAWA type),. These clinical features resembled those of 
Kennedy-Alter-Sung syndrome. Most HMSNP patients have severe muscle atrophy 
and finally the tracheostomy and artificial ventilation are required. 
Therefore, we initially thought to classify HMSNP into a subtype of motor 
neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or 
spinal muscular atrophy (SMA). However, the general consensus for MND was no 
sensory involvement. Therefore, as the disease showed severe sensory 
involvement, we categorized HMSNP in subtype of HMSN at that time. We also 
reported the pathology of HMSNP, showing severely decreased anterior horn 
cells, decreased posterior horn cells, and loss of posterior funiculus in 
the spinal cord.
EMTREE MEDICAL INDEX TERMS
  hereditary motor sensory neuropathy; history; human; Japan; 
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  24291927 (http://www.ncbi.nlm.nih.gov/pubmed/24291927)
PUI
  L603704788
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18820654&id=doi:&atitle=History+of+hereditary+motor+and+sensory+neuropathy+with+proximal+dominant+involvement+%28HMSN-P%29&stitle=Rinsho+Shinkeigaku&title=Rinsh%C5%8D+shinkeigaku+%3D+Clinical+neurology&volume=23&issue=11&spage=1196&epage=1198&aulast=Takashima&aufirst=Hiroshi&auinit=H.&aufull=Takashima+H.&coden=&isbn=&pages=1196-1198&date=2013&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2015 Medline is the source for the citation and abstract of this 
record.

RECORD 555
TITLE
  A complete C3-C4 spinal dislocation
AUTHOR NAMES
  Yang H.-L.; Zhang Z.-G.; Luo Z.-P.
AUTHOR ADDRESSES
  (Yang H.-L.; Zhang Z.-G.; Luo Z.-P., zongping_luo@yahoo.com) Department of 
Orthopedics, First Affiliated Hospital and Orthopedic Institute, Soochow 
University, 708 Renmin Rd, Suzhou, Jiangsu 215007, China.
CORRESPONDENCE ADDRESS
  Z.-P. Luo, Department of Orthopedics, First Affiliated Hospital and 
Orthopedic Institute, Soochow University, 708 Renmin Rd, Suzhou, Jiangsu 
215007, China. Email: zongping_luo@yahoo.com
FULL RECORD ENTRY DATE
  2013-06-18
SOURCE
  JAMA Neurology (2013) 70:6 (802). Date of Publication: June 2013
VOLUME
  70
ISSUE
  6
FIRST PAGE
  802
DATE OF PUBLICATION
  June 2013
ISSN
  2168-6149
BOOK PUBLISHER
  American Medical Association, smcleod@itsa.ucsf.edu
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine dislocation (diagnosis, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; cast application; cervical spine injury; human; incontinence; male; paralysis; priority journal; tracheotomy; traction therapy; traffic accident; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013365697
MEDLINE PMID
  23753965 (http://www.ncbi.nlm.nih.gov/pubmed/23753965)
PUI
  L369080707
DOI
  10.1001/jamaneurol.2013.1948
FULL TEXT LINK
  http://dx.doi.org/10.1001/jamaneurol.2013.1948
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21686149&id=doi:10.1001%2Fjamaneurol.2013.1948&atitle=A+complete+C3-C4+spinal+dislocation&stitle=JAMA+Neurol.&title=JAMA+Neurology&volume=70&issue=6&spage=802&epage=&aulast=Yang&aufirst=Hui-Lin&auinit=H.-L.&aufull=Yang+H.-L.&coden=&isbn=&pages=802-&date=2013&auinit1=H&auinitm=-L
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 556
TITLE
  Anaesthesia and airway management in mucopolysaccharidosis
AUTHOR NAMES
  Walker R.; Belani K.G.; Braunlin E.A.; Bruce I.A.; Hack H.; Harmatz P.R.; Jones S.; Rowe R.; Solanki G.A.; Valdemarsson B.
AUTHOR ADDRESSES
  (Walker R., Robert.Walker@cmft.nhs.uk; Bruce I.A.; Hack H.) Royal Manchester 
Children's Hospital, Oxford Road, Manchester M13 9WL, United Kingdom.
(Belani K.G.; Braunlin E.A.) University of Minnesota, Minneapolis, MN, 
United States.
(Harmatz P.R.; Rowe R.) Children's Hospital, Research Center Oakland, 
Oakland, CA, United States.
(Jones S.) St Mary's Hospital, Manchester, United Kingdom.
(Solanki G.A.) Birmingham Children's Hospital, Birmingham, United Kingdom.
(Valdemarsson B.) Queen Sylvia's Children Hospital, Gothenburg, Sweden.
CORRESPONDENCE ADDRESS
  R. Walker, Royal Manchester Children's Hospital, Oxford Road, Manchester M13 
9WL, United Kingdom. Email: Robert.Walker@cmft.nhs.uk
AiP/IP ENTRY DATE
  2012-12-07
FULL RECORD ENTRY DATE
  2013-07-24
SOURCE
  Journal of Inherited Metabolic Disease (2013) 36:2 (211-219). Date of 
Publication: March 2013
VOLUME
  36
ISSUE
  2
FIRST PAGE
  211
LAST PAGE
  219
DATE OF PUBLICATION
  March 2013
ISSN
  1573-2665 (electronic)
  0141-8955
BOOK PUBLISHER
  Kluwer Academic Publishers
ABSTRACT
  This paper provides a detailed overview and discussion of anaesthesia in 
patients with mucopolysaccharidosis (MPS), the evaluation of risk factors in 
these patients and their anaesthetic management, including emergency airway 
issues. MPS represents a group of rare lysosomal storage disorders 
associated with an array of clinical manifestations. The high prevalence of 
airway obstruction and restrictive pulmonary disease in combination with 
cardiovascular manifestations poses a high anaesthetic risk to these 
patients. Typical anaesthetic problems include airway obstruction after 
induction or extubation, intubation difficulties or failure [can't intubate, 
can't ventilate (CICV)], possible emergency tracheostomy and cardiovascular 
and cervical spine issues. Because of the high anaesthetic risk, the 
benefits of a procedure in patients with MPS should always be balanced 
against the associated risks. Therefore, careful evaluation of anaesthetic 
risk factors should be made before the procedure, involving evaluation of 
airways and cardiorespiratory and cervical spine problems. In addition, 
information on the specific type of MPS, prior history of anaesthesia, 
presence of cervical instability and range of motion of the 
temporomandibular joint are important and may be pivotal to prevent 
complications during anaesthesia. Knowledge of these risk factors allows the 
anaesthetist to anticipate potential problems that may arise during or after 
the procedure. Anaesthesia in MPS patients should be preferably done by an 
experienced (paediatric) anaesthetist, supported by a multidisciplinary team 
(ear, nose, throat surgeon and intensive care team), with access to all 
necessary equipment and support. © 2012 The Author(s).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia induction; mucopolysaccharidosis (surgery, therapy); respiration control; 
EMTREE MEDICAL INDEX TERMS
  airway obstruction (complication, diagnosis, surgery); article; cardiopulmonary insufficiency (complication, diagnosis); cardiovascular disease (complication); chronic obstructive lung disease (complication); clinical feature; disease association; endotracheal intubation; enzyme replacement; extubation; hematopoietic stem cell transplantation; high risk patient; human; life expectancy; multidetector computed tomography; prevalence; range of motion; respiratory failure (complication); risk benefit analysis; spinal cord compression (complication, diagnosis); spine instability (complication, diagnosis); surgical mortality; surgical risk; temporomandibular joint; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013413811
MEDLINE PMID
  23197104 (http://www.ncbi.nlm.nih.gov/pubmed/23197104)
PUI
  L52329747
DOI
  10.1007/s10545-012-9563-1
FULL TEXT LINK
  http://dx.doi.org/10.1007/s10545-012-9563-1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15732665&id=doi:10.1007%2Fs10545-012-9563-1&atitle=Anaesthesia+and+airway+management+in+mucopolysaccharidosis&stitle=J.+Inherit.+Metab.+Dis.&title=Journal+of+Inherited+Metabolic+Disease&volume=36&issue=2&spage=211&epage=219&aulast=Walker&aufirst=Robert&auinit=R.&aufull=Walker+R.&coden=JIMDD&isbn=&pages=211-219&date=2013&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 557
TITLE
  Clinical and radiological pictures of two newborn babies with manifestations 
of chondrodysplasia punctata and review of available literature
AUTHOR NAMES
  Jurkiewicz E.; Marcinska B.; Bothur-Nowacka J.; Dobrzanska A.
AUTHOR ADDRESSES
  (Jurkiewicz E., e-jurkiewicz@o2.pl; Marcinska B.) Department of Imaging 
Diagnostics, Children's Health Memorial Institute, Warsaw, Poland.
(Bothur-Nowacka J.; Dobrzanska A.) Department of Neonatology, Pathology and 
Intensive Neonatal Care, Children's Health Memorial Institute, Warsaw, 
Poland.
CORRESPONDENCE ADDRESS
  E. Jurkiewicz, Department of Imaging Diagnostics, Children's Health Memorial 
Institute, Al. Dzieci Polskich 20 St, 04-730 Warsaw, Poland. Email: 
e-jurkiewicz@o2.pl
AiP/IP ENTRY DATE
  2013-06-21
FULL RECORD ENTRY DATE
  2013-07-01
SOURCE
  Polish Journal of Radiology (2013) 78:2 (57-64). Date of Publication: 2013
VOLUME
  78
ISSUE
  2
FIRST PAGE
  57
LAST PAGE
  64
DATE OF PUBLICATION
  2013
ISSN
  1899-0967 (electronic)
  1733-134X
BOOK PUBLISHER
  Medical Science International, office@isl-science.com
ABSTRACT
  Background: Chondrodysplasia punctata (CDP) is a rare, heterogeneous 
congenital skeletal dysplasia, characterized by punctate or dot-like calcium 
deposits in cartilage observed on neonatal radiograms. A number of inborn 
metabolic diseases are associated with CDP, including peroxisomal and 
cholesterol biosynthesis dysfunction and other inborn errors of metabolism 
such as: mucolipidosis type II, mucopolysacharidosis type III, GM1 
gangliosidosis. CDP is also related to disruption of vitamin K-dependent 
metabolism, causing secondary effects on the embryo, as well as fetal 
alcohol syndrome (FAS), chromosomal abnormalities that include trisomies 18 
and 21, Turner syndrome. Case Report: This article presents clinical data 
and diagnostic imaging findings of two newborn babies with chondrodysplasia 
punctata. Children presented with skeletal and cartilage anomalies, 
dysmorphic facial feature, muscles tone abnormalities, skin changes and 
breathing difficulties. One of the patients demonstrated critical stenosis 
of spinal canal with anterior subluxation of C1 vertebra relative to C 2. 
The aim of this article is to present cases and briefly describe current 
knowledge on etiopathogenesis as well as radiological and clinical symptoms 
of diseases coexisting with CDP. Conclusions: Radiological diagnostic 
imaging allows for visualization of punctate focal mineralization in bone 
epiphyses during neonatal age and infancy. Determining the etiology of 
chondrodysplasia punctata requires performing various basic as well as 
additional examinations, including genetic studies. © Pol J Radiol, 2013.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chondrodysplasia punctata; 
EMTREE MEDICAL INDEX TERMS
  article; asphyxia; bone radiography; breathing disorder; case report; chromosome aberration; computer assisted tomography; craniofacial malformation; differential diagnosis; hearing impairment; human; male; muscle hypotonia; newborn; nuclear magnetic resonance imaging; spinal cord compression; thorax radiography; tracheostomy; Zellweger syndrome; 
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013376212
PUI
  L369110921
DOI
  10.12659/PJR.883947
FULL TEXT LINK
  http://dx.doi.org/10.12659/PJR.883947
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18990967&id=doi:10.12659%2FPJR.883947&atitle=Clinical+and+radiological+pictures+of+two+newborn+babies+with+manifestations+of+chondrodysplasia+punctata+and+review+of+available+literature&stitle=Pol.+J.+Radiol.&title=Polish+Journal+of+Radiology&volume=78&issue=2&spage=57&epage=64&aulast=Jurkiewicz&aufirst=Elzbieta&auinit=E.&aufull=Jurkiewicz+E.&coden=PJROB&isbn=&pages=57-64&date=2013&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 558
TITLE
  Accumulation of phosphorylated TDP-43 in the CNS of a patient with cockayne 
syndrome
AUTHOR NAMES
  Sakurai A.; Makioka K.; Fukuda T.; Takatama M.; Okamoto K.
AUTHOR ADDRESSES
  (Sakurai A., sakurai@h-sawarabi.com; Makioka K.; Okamoto K.) Department of 
Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.
(Fukuda T.) Gunma University Graduate School of Health Sciences, Maebashi, 
Japan.
(Takatama M.) Department of Medicine, Geriatrics Research Institute and 
Hospital, Maebashi, Japan.
(Sakurai A., sakurai@h-sawarabi.com) Department of Neurology, Hanna-Sawarabi 
Ryoikuen, Takasaki, Gunma, Japan.
CORRESPONDENCE ADDRESS
  A. Sakurai, Department of Neurology, Hanna-Sawarabi Ryoikuen, 28-30 
Harunasan-machi, Takasaki, Gunma 370-3341, Japan. Email: 
sakurai@h-sawarabi.com
AiP/IP ENTRY DATE
  2013-04-26
FULL RECORD ENTRY DATE
  2014-04-09
SOURCE
  Neuropathology (2013) 33:6 (673-677). Date of Publication: December 2013
VOLUME
  33
ISSUE
  6
FIRST PAGE
  673
LAST PAGE
  677
DATE OF PUBLICATION
  December 2013
ISSN
  1440-1789 (electronic)
  0919-6544
BOOK PUBLISHER
  Blackwell Publishing, info@asia.blackpublishing.com.au
ABSTRACT
  Here, we report a case of Cockayne syndrome (CS) in a Japanese man who 
displayed a unique pathology of phosphorylated trans-activation response 
(TAR) DNA-binding protein 43 (pTDP-43) with abundant Rosenthal fibers. Many 
round pTDP-43-positive structures were detected throughout the CNS; however, 
most of them were located in two regions that also exhibited neuronal 
depletion: the cerebellar cortex and the inferior olivary nucleus. To a 
lesser extent, these aggregates were also present in the cerebellar white 
matter, around the subependymal regions in the brain stem, and in the spinal 
cord. Intraneuronal pTDP-43 inclusions were only observed in a small number 
of neurons in the inferior olivary nucleus. Double-label immunofluorescence 
revealed that many of the aggregates were localized to astrocytes. The 
observed distribution and the morphology of the pTDP-43-positive structures 
were unique and have not yet been reported. Therefore, a pTDP-43-related 
pathology may be implicated in CS as well as in other neurodegenerative 
diseases such as frontotemporal lobar degeneration and amyotrophic lateral 
sclerosis. Whether the pathology of these diseases reflects a primary 
neurodegenerative process or a secondary reaction is not known. © 2013 
Japanese Society of Neuropathology.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  TAR DNA binding protein (endogenous compound); 
EMTREE DRUG INDEX TERMS
  glial fibrillary acidic protein (endogenous compound); microtubule associated protein 2 (endogenous compound); myelin (endogenous compound); protein antibody; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  central nervous system; Cockayne syndrome (congenital disorder, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; article; aspiration pneumonia; astrocyte; astrocytosis; ataxia; autopsy; body weight; brain degeneration; brain stem; cachexia; case report; cause of death; cell inclusion; cerebellum cortex; cervical dystonia; computer assisted tomography; confocal microscopy; convulsion; dental caries; dwarfism; dysarthria; dysphagia; emaciation; enteric feeding; facies; foot malformation; gait disorder; growth disorder; hand malformation; hand tremor; hearing impairment; hospital admission; human; human cell; immunofluorescence; immunohistochemistry; immunoreactivity; inferior olivary nucleus; Japanese (people); joint contracture; lateral brain ventricle; lentigo; male; mental deficiency; neuroimaging; neurologic examination; neuropathology; nystagmus; photosensitivity; physical examination; priority journal; progeria; protein depletion; protein expression; protein localization; protein phosphorylation; protein structure; psychomotor retardation; pyramidal sign; respiratory failure; rosenthal fiber; scoliosis; skin fibroblast; smooth pursuit eye movement; spinal cord atrophy; subventricular zone; survival; tracheal hemorrhage; tracheostomy; ultraviolet irradiation; white matter lesion; 
EMBASE CLASSIFICATIONS
  Psychiatry (32)
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2014213300
MEDLINE PMID
  23581709 (http://www.ncbi.nlm.nih.gov/pubmed/23581709)
PUI
  L52550316
DOI
  10.1111/neup.12038
FULL TEXT LINK
  http://dx.doi.org/10.1111/neup.12038
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14401789&id=doi:10.1111%2Fneup.12038&atitle=Accumulation+of+phosphorylated+TDP-43+in+the+CNS+of+a+patient+with+cockayne+syndrome&stitle=Neuropathology&title=Neuropathology&volume=33&issue=6&spage=673&epage=677&aulast=Sakurai&aufirst=Atsushi&auinit=A.&aufull=Sakurai+A.&coden=NOPAF&isbn=&pages=673-677&date=2013&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 559
TITLE
  Spontaneous spinal epidural abscess presenting in a previously healthy young 
adult man
AUTHOR NAMES
  McDonald A.M.; Rollins J.L.
AUTHOR ADDRESSES
  (McDonald A.M., friezu@uab.edu; Rollins J.L., andrew.mcdonald@bhsala.com) 
Department of Medical Education, Princeton Baptist Medical Center, 3201 4th 
Avenue S, Birmingham, AL 35222, United States.
CORRESPONDENCE ADDRESS
  A.M. McDonald, Department of Medical Education, Princeton Baptist Medical 
Center, 3201 4th Avenue S, Birmingham, AL 35222, United States. Email: 
friezu@uab.edu
AiP/IP ENTRY DATE
  2013-09-25
FULL RECORD ENTRY DATE
  2013-09-30
SOURCE
  Case Reports in Medicine (2013) 2013 Article Number: 872148. Date of 
Publication: 2013
VOLUME
  2013
DATE OF PUBLICATION
  2013
ISSN
  1687-9635 (electronic)
  1687-9627
BOOK PUBLISHER
  Hindawi Limited, 410 Park Avenue, 15th Floor, 287 pmb, New York, United 
States.
ABSTRACT
  We report a case of spontaneous spinal epidural abscess (SEA) with initial 
chief complaint of shoulder pain and no appreciable neurologic symptoms. 
Since outcomes of SEA appear to be related to the degree of neurologic 
deficit at the time of intervention, we explore opportunities for earlier 
diagnosis. © 2013 Andrew M. McDonald and Jason L. Rollins.
EMTREE DRUG INDEX TERMS
  D dimer (endogenous compound); doxycycline (oral drug administration); hemoglobin (endogenous compound); hydrocodone; linezolid; methocarbamol; methylprednisolone; paracetamol; vancomycin (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidural abscess; spinal epidural abscess; 
EMTREE MEDICAL INDEX TERMS
  adult; adult respiratory distress syndrome; ambulance; arterial gas; article; barotrauma; blood culture; blood pressure measurement; body temperature; bradycardia; breathing rate; cardiopulmonary arrest; case report; cervical spine; cervicobrachial neuralgia; computed tomographic angiography; contrast enhancement; debridement; density; diaphoresis; emergency ward; erythrocyte sedimentation rate; fiberoptic bronchoscopy; hospital discharge; human; intubation; lung embolism; male; medical history; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; muscle weakness; nausea and vomiting; nuclear magnetic resonance imaging; outpatient; oxygen saturation; oxygen tension; paresthesia; physical examination; pneumothorax; prescription; priority journal; pulse oximetry; pulse rate; quantitative analysis; respiratory distress; sedation; sensation; shoulder pain; shoulder radiography; spinal cord injury; surgical wound; tachypnea; tracheobronchial toilet; tracheostomy; transesophageal echocardiography; trapezius muscle; vacuum assisted closure; vagus tone; ventilator; vital sign; 
CAS REGISTRY NUMBERS
  doxycycline (10592-13-9, 17086-28-1, 564-25-0, 94088-85-4)
  hemoglobin (9008-02-0)
  hydrocodone (125-29-1, 25968-91-6, 34366-67-1)
  linezolid (165800-03-3)
  methocarbamol (532-03-6)
  methylprednisolone (6923-42-8, 83-43-2)
  paracetamol (103-90-2)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013586575
PUI
  L369831317
DOI
  10.1155/2013/872148
FULL TEXT LINK
  http://dx.doi.org/10.1155/2013/872148
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16879635&id=doi:10.1155%2F2013%2F872148&atitle=Spontaneous+spinal+epidural+abscess+presenting+in+a+previously+healthy+young+adult+man&stitle=Case+Rep.+Med.&title=Case+Reports+in+Medicine&volume=2013&issue=&spage=&epage=&aulast=McDonald&aufirst=Andrew+M.&auinit=A.M.&aufull=McDonald+A.M.&coden=&isbn=&pages=-&date=2013&auinit1=A&auinitm=M
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 560
TITLE
  Analysis of the risk factors for tracheostomy in traumatic cervical spinal 
cord injury
AUTHOR NAMES
  Yugué I.; Okada S.; Ueta T.; Maeda T.; Mori E.; Kawano O.; Takao T.; Sakai H.; Masuda M.; Hayashi T.; Morishita Y.; Shiba K.
AUTHOR ADDRESSES
  (Yugué I., iyugue@orange.ocn.ne.jp; Ueta T.; Maeda T.; Mori E.; Kawano O.; 
Takao T.; Sakai H.; Masuda M.; Hayashi T.; Morishita Y.; Shiba K.) 
Department of Orthopaedic Surgery, Spinal Injuries Center, 550-4 Igisu, 
Iizuka, Fukuoka, Japan.
(Okada S.) Department of Orthopaedic Surgery, Kyushu University, Fukuoka, 
Japan.
CORRESPONDENCE ADDRESS
  I. Yugué, Department of Orthopaedic Surgery, Spinal Injuries Center, 550-4 
Igisu, Iizuka, Fukuoka, Japan. Email: iyugue@orange.ocn.ne.jp
AiP/IP ENTRY DATE
  2012-09-25
FULL RECORD ENTRY DATE
  2013-01-30
SOURCE
  Spine (2012) 37:26 (E1633-E1638). Date of Publication: 15 Dec 2012
VOLUME
  37
ISSUE
  26
DATE OF PUBLICATION
  15 Dec 2012
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  STUDY DESIGN. A retrospective, consecutive case series. OBJECTIVE. To 
determine the risk factors that have a statistically significant association 
with the need of tracheostomy in patients with cervical spinal cord injury 
(CSCI) at the acute stage. SUMMARY OF BACKGROUND DATA. Respiratory 
complications remain a major cause of further morbidity and mortality in 
patients with CSCI. Although several risk factors for tracheostomy have been 
postulated in these patients, no definitive factors have yet been 
established according to a multivariate analysis. The use of vital capacity 
was considered as a single global measure of respiratory function in 
patients with spinal cord injury, but there are very few studies in which 
the forced vital capacity was investigated as a risk factor for 
tracheostomy. METHODS. This study that reviewed the clinical data of 319 
patients with CSCI, who were evaluated for their neurological impairment 
within 2 days after injury, was performed. We analyzed the factors 
postulated to increase the risk for tracheostomy, including patient's age, 
neurological impairment scale grade and level, smoking history, pre-existing 
medical comorbidities, respiratory diseases, Injury Severity Score, forced 
vital capacity, and percentage of vital capacity to the predicted value 
(%VC), using a multiple logistic regression model and classification and 
regression tree analysis. RESULTS. Of 319 patients, 32 patients received 
tracheostomy (10.03%). The factors identified using a multiple logistic 
regression model were high age (69 years of age or older), severe 
neurological impairment scale, low forced vital capacity (≤500 mL), and low 
percentage of vital capacity to the predicted value (<16.3%). The decision 
tree analysis demonstrated that forced vital capacity, the severe 
neurological impairment scale, and high patient age were predictive of need 
for tracheostomy on 94.4% occasions. CONCLUSION. The measurement of forced 
vital capacity is indispensable to predict the need for tracheostomy in 
patients with CSCI at the acute stage. © 2012, Lippincott Williams & 
Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; risk factor; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  acute disease; adolescent; adult; aged; article; comorbidity; decision tree; female; forced vital capacity; groups by age; human; injury scale; major clinical study; male; neurologic disease; neurological impairment scale; priority journal; rating scale; respiratory tract disease; smoking; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013041142
MEDLINE PMID
  22996266 (http://www.ncbi.nlm.nih.gov/pubmed/22996266)
PUI
  L52220463
DOI
  10.1097/BRS.0b013e31827417f1
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e31827417f1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e31827417f1&atitle=Analysis+of+the+risk+factors+for+tracheostomy+in+traumatic+cervical+spinal+cord+injury&stitle=Spine&title=Spine&volume=37&issue=26&spage=&epage=&aulast=Yugu%C3%A9&aufirst=Itaru&auinit=I.&aufull=Yugu%C3%A9+I.&coden=SPIND&isbn=&pages=-&date=2012&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 561
TITLE
  Familial ALS with FUS P525L mutation: Two Japanese sisters with multiple 
systems involvement
AUTHOR NAMES
  Mochizuki Y.; Isozaki E.; Takao M.; Hashimoto T.; Shibuya M.; Arai M.; Hosokawa M.; Kawata A.; Oyanagi K.; Mihara B.; Mizutani T.
AUTHOR ADDRESSES
  (Mochizuki Y., mochi@nihon-u.ne.jp; Shibuya M.; Mizutani T.) Department of 
Pathology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai 
Fuchu-shi, Tokyo 183-0042, Japan.
(Isozaki E.; Kawata A.) Department of Neurology, Tokyo Metropolitan 
Neurological Hospital, Tokyo 183-0042, Japan.
(Takao M.) Division of Neuropathology, Mihara Memorial Hospital, Gunma 
372-0006, Japan.
(Hashimoto T.; Oyanagi K.) Department of Neuropathology, Tokyo Metropolitan 
Institute for Neuroscience, Tokyo 183-8526, Japan.
(Hashimoto T.; Oyanagi K.) Division of Neuropathology, Department of Brain 
Disease Research, Shinshu University School of Medicine, Nagano, Japan.
(Shibuya M.) Department of Pathology, Tokyo Medical University, Ibaraki 
Medical Center, Ibaraki 300-0395, Japan.
(Arai M.; Hosokawa M.) Department of Neuropathology, Tokyo Metropolitan 
Institute of Medical Science, Tokyo 156-8506, Japan.
(Mihara B.) Department of Neurology, Mihara Memorial Hospital, Gunma 
372-0006, Japan.
(Mizutani T.) Fuchu Medical Center for the Disabled, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  Y. Mochizuki, Department of Pathology, Tokyo Metropolitan Neurological 
Hospital, 2-6-1 Musashidai Fuchu-shi, Tokyo 183-0042, Japan. Email: 
mochi@nihon-u.ne.jp
AiP/IP ENTRY DATE
  2012-09-15
FULL RECORD ENTRY DATE
  2012-11-05
SOURCE
  Journal of the Neurological Sciences (2012) 323:1-2 (85-92). Date of 
Publication: 15 Dec 2012
VOLUME
  323
ISSUE
  1-2
FIRST PAGE
  85
LAST PAGE
  92
DATE OF PUBLICATION
  15 Dec 2012
ISSN
  0022-510X
  1878-5883 (electronic)
BOOK PUBLISHER
  Elsevier, P.O. Box 211, Amsterdam, Netherlands.
ABSTRACT
  We evaluated the clinicopathological features of familial amyotrophic 
lateral sclerosis (ALS) with the fused in sarcoma (FUS) P525L mutation. Two 
sisters and their mother had a similar clinical course, which was 
characterized by the development of limb weakness at a young age with rapid 
disease progression. An elder sister, patient 1, progressed into a totally 
locked-in state requiring mechanical ventilation and died 26 years after the 
onset of the disease. In contrast, the younger sister, patient 2, died in 
the early stages of the disease. The patients had neuropathological findings 
that indicated a very active degeneration of motor neurons and multiple 
system degeneration, which led to marked brain and spinal cord atrophy in 
the long term clinical outcome. The multiple system degeneration included 
the frontal lobe, the basal ganglia and substantia nigra, cerebellum and 
related area. Compared with previously reported ALS cases, the severe 
degeneration of the frontal lobe and the striatum were the characteristic 
features in the patient 1 in this case study. The degeneration spread over 
multiple systems might be caused not only by the appearance of the FUS 
immunoreactive neuronal cytoplasmic inclusions but also by the degeneration 
of neuronal connections from the primary motor cortex and related areas. © 
2012 Elsevier B.V. All rights reserved.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  RNA binding protein FUS (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (diagnosis, etiology, surgery); multiple organ failure; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; arm weakness; article; artificial ventilation; basal ganglion; bulbar paralysis; case report; cerebellum; comparative study; degeneration; developmental disorder; disease course; dysarthria; dysphagia; dyspnea; familial disease (diagnosis, etiology, surgery); female; frontal lobe; gene mutation; genetic association; human; human cell; human tissue; Japanese (people); limb weakness; neuropathology; ophthalmoplegia; pneumonia; polyneuropathy; primary motor cortex; priority journal; quadriplegia; respiratory failure; spinal cord atrophy; substantia nigra; tracheostomy; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Human Genetics (22)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012622838
MEDLINE PMID
  22980027 (http://www.ncbi.nlm.nih.gov/pubmed/22980027)
PUI
  L52204572
DOI
  10.1016/j.jns.2012.08.016
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jns.2012.08.016
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0022510X&id=doi:10.1016%2Fj.jns.2012.08.016&atitle=Familial+ALS+with+FUS+P525L+mutation%3A+Two+Japanese+sisters+with+multiple+systems+involvement&stitle=J.+Neurol.+Sci.&title=Journal+of+the+Neurological+Sciences&volume=323&issue=1-2&spage=85&epage=92&aulast=Mochizuki&aufirst=Yoko&auinit=Y.&aufull=Mochizuki+Y.&coden=JNSCA&isbn=&pages=85-92&date=2012&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 562
TITLE
  Risk factors for respiratory failure in elderly patients with traumatic rib 
fractures
AUTHOR NAMES
  Ng S.Y.; Seethala R.; Yang Y.; Gonzalez C.; Kappottos M.; Frendl G.; Shempp I.; Rogers S.
AUTHOR ADDRESSES
  (Ng S.Y.; Yang Y.) Singapore General Hospital, Singapore.
(Seethala R.; Gonzalez C.; Kappottos M.; Shempp I.) Brigham and Women's 
Hospital, United States.
(Frendl G.) Brigham and Women's Hosp, Harvard Med.School, United States.
(Rogers S.) Temple University Hospital, United States.
CORRESPONDENCE ADDRESS
  S.Y. Ng, Singapore General Hospital, Singapore.
FULL RECORD ENTRY DATE
  2013-05-27
SOURCE
  Critical Care Medicine (2012) 40:12 SUPPL. 1 (53-54). Date of Publication: 
December 2012
VOLUME
  40
ISSUE
  12
FIRST PAGE
  53
LAST PAGE
  54
DATE OF PUBLICATION
  December 2012
CONFERENCE NAME
  42nd Critical Care Congress of the Society of Critical Care Medicine, SCCM 
2013
CONFERENCE LOCATION
  San Juan, Puerto Rico
CONFERENCE DATE
  2013-01-19 to 2013-01-23
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Elderly patients aged > 65 years have increased mortality and 
morbidity after sustaining traumatic rib fractures. While the incidence of 
pulmonary morbidity is increased, the risk factors are unknown. Hypothesis: 
We hypothesized that advanced elderly age (? 80 years), comorbidities such 
as cardiovascular and cerebrovascular diseases, smoking and obesity, injury 
severity and presence of traumatic brain or cervical spine injury may 
increase the risk for respiratory failure. Methods: The study was a 
retrospective review over a 10 year period of a prospectively collected 
trauma registry. Variables and outcomes described above were collected.We 
used a composite outcome for respiratory failure consisting of unplanned 
intubation, tracheostomy and / or development of pneumonia. Univariate 
analysis followed by logistic regression was performed to identify the risk 
factors for respiratory failure. Results: 449 patients with traumatic rib 
fractures over a 10 year period were analyzed. The mean age was 78.1 ± 8.0. 
There were 249 patients aged 65 to 79 and 200 patients aged 80 and above. 
The mean Injury Severity Score and Abbreviated Injury Score (chest) was 17.5 
± 11.0 and 2.4 ± 1.1 respectively. The mean number of fractured ribs was 4.0 
± 3.1. 142 (31.6%) patients had respiratory failure. 45 (10.0%) patients 
died in hospital.On univariate analysis, only the presence of cervical spine 
injury and Abbreviated Injury Score (chest) were associated with respiratory 
failure. The association remained after logistic regression: the ORs for 
respiratory failure in the presence of cervical spine injury and AIS (chest) 
were 3.25 (95% CI: 1.97 -5.35) and 1.56 (95% CI: 1.25 - 1.90) respectively. 
There was a positive interaction between age group and presence of cervical 
spine injury for respiratory failure (p = 0.001)Conclusions: The risk 
factors for respiratory failure in elderly patients with traumatic rib 
fractures are the presence of cervical spine injury and increased AIS 
(chest) score. The presence of cervical spine injury may have a greater 
effect in the advanced elderly age group. This data will be useful in 
identifying elderly patients at risk of respiratory failure after sustaining 
traumatic rib fractures.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aged; human; intensive care; respiratory failure; rib fracture; risk factor; society; 
EMTREE MEDICAL INDEX TERMS
  brain; cerebrovascular disease; cervical spine injury; groups by age; hypothesis; injury; injury scale; injury severity; intubation; logistic regression analysis; morbidity; mortality; obesity; patient; pneumonia; register; rib; risk; smoking; thorax; tracheostomy; univariate analysis; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71065379
DOI
  10.1097/01.ccm.0000425605.04623.4b
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000425605.04623.4b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000425605.04623.4b&atitle=Risk+factors+for+respiratory+failure+in+elderly+patients+with+traumatic+rib+fractures&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=40&issue=12&spage=53&epage=54&aulast=Ng&aufirst=Shin+Yi&auinit=S.Y.&aufull=Ng+S.Y.&coden=&isbn=&pages=53-54&date=2012&auinit1=S&auinitm=Y
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 563
TITLE
  Respiratory Complications and Management of Mechanical Ventilation in 
Cervical Spine Injury
AUTHOR NAMES
  Kearns M.; Shimabukuro D.
AUTHOR ADDRESSES
  (Kearns M.) Fellow in Critical Care Medicine, University of California, San 
Francisco, United States.
(Shimabukuro D., shimabud@anesthesia.ucsf.edu) University of California, San 
Francisco, United States.
CORRESPONDENCE ADDRESS
  D. Shimabukuro, University of California, San Francisco, 505 Parnassus 
Avenue, M917 Box 0624, San Francisco, CA 94143-0624, United States. Email: 
shimabud@anesthesia.ucsf.edu
AiP/IP ENTRY DATE
  2013-04-05
FULL RECORD ENTRY DATE
  2013-04-17
SOURCE
  ICU Director (2012) 3:5 (220-223). Date of Publication: 2012
VOLUME
  3
ISSUE
  5
FIRST PAGE
  220
LAST PAGE
  223
DATE OF PUBLICATION
  2012
ISSN
  1944-4516
  1944-4524 (electronic)
BOOK PUBLISHER
  SAGE Publications Inc., 2455 Teller Road, Thousand Oaks, United States.
ABSTRACT
  It is estimated that the annual incidence of spinal cord injury in the 
United States is 12 000 new cases per year. Victims of spinal cord injury 
are prone to developing respiratory complications such as atelectasis, 
pneumonia, and ventilatory failure secondary to physiologic derangements 
resulting from spinal shock and paralysis. Respiratory complications are the 
leading cause of death in those who survive the initial injury. The goal in 
ventilator management of spinal cord injury patients in the intensive care 
unit setting is to prevent these complications and optimize patients for 
early transfer to a spinal cord rehabilitation facility. To minimize 
atelectasis, current guidelines recommend the use of very high tidal volumes 
(15 mL/kg) or setting high tidal volumes (10 mL/kg) in addition to using 
positive end-expiratory pressure. In this article, the authors discuss the 
pulmonary complications that affect the mortality of these patients and 
review the evidence behind the current high tidal volume ventilation 
strategy. © 2012 The Author(s).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spine injury; respiratory tract disease (complication); 
EMTREE MEDICAL INDEX TERMS
  article; atelectasis (complication); bronchospasm (complication); disease severity; human; incidence; intensive care unit; lung edema (complication); pneumonia (complication); positive end expiratory pressure; practice guideline; priority journal; respiratory failure; risk factor; tidal volume; tracheostomy; ventilated patient; ventilator induced lung injury (complication); vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013202664
PUI
  L368610782
DOI
  10.1177/1944451612457568
FULL TEXT LINK
  http://dx.doi.org/10.1177/1944451612457568
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19444516&id=doi:10.1177%2F1944451612457568&atitle=Respiratory+Complications+and+Management+of+Mechanical+Ventilation+in+Cervical+Spine+Injury&stitle=ICU+Dir.&title=ICU+Director&volume=3&issue=5&spage=220&epage=223&aulast=Kearns&aufirst=Michel&auinit=M.&aufull=Kearns+M.&coden=&isbn=&pages=220-223&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 564
TITLE
  Diffusion tensor imaging in pediatric transverse myelitis: A case study
AUTHOR NAMES
  Barakat N.; Mulcahey M.J.; Shah P.; Samdani A.; Krisa L.; Faro S.; Mohamed F.B.
AUTHOR ADDRESSES
  (Barakat N., nbarakat@shrinenet.org; Mulcahey M.J.; Samdani A.; Krisa L.) 
Clinical Research Department, Shriners Hospitals for Children, 3551 North 
Broad Street, Philadelphia, PA 19140, United States.
(Barakat N., nbarakat@shrinenet.org; Shah P.; Faro S.; Mohamed F.B.) 
Department of Radiology, Temple University, Philadelphia, PA, United States.
CORRESPONDENCE ADDRESS
  N. Barakat, Clinical Research Department, Shriners Hospitals for Children, 
3551 North Broad Street, Philadelphia, PA 19140, United States. Email: 
nbarakat@shrinenet.org
AiP/IP ENTRY DATE
  2013-03-05
FULL RECORD ENTRY DATE
  2013-03-20
SOURCE
  Journal of Pediatric Rehabilitation Medicine (2012) 5:4 (281-286). Date of 
Publication: 2012
  Spinal Cord Injury, Book Series Title:
VOLUME
  5
ISSUE
  4
FIRST PAGE
  281
LAST PAGE
  286
DATE OF PUBLICATION
  2012
ISSN
  1874-5393
  1875-8894 (electronic)
BOOK PUBLISHER
  IOS Press, Nieuwe Hemweg 6B, Amsterdam, Netherlands.
ABSTRACT
  Transverse myelitis is diagnosed based on the presence of spinal cord 
inflammation and the absence of infection to the central nervous system. In 
support of these criteria, patients undergo lumbar puncture to determine 
Cerebrospinal Fluid (CSF) pleocytosis and un-enhanced or Gadolinium-enhanced 
spinal Magnetic Resonance Imaging (MRI). We present the case of an 
11~year-old previously healthy male who underwent a series of lab tests and 
MRI scans before a definite diagnosis of transverse myelitis four years 
prior to this study. The patient still shows deficits at the C4 cord level 
according to International Standards for Neurological Classification of 
Spinal Cord Injury (ISNCSCI) examination, however, his MRI results are 
negative, and his Diffusion Tensor Imaging (DTI) results are close to values 
reported in healthy subjects. © 2012 - IOS Press and the authors. All rights 
reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diffusion tensor imaging; myelitis; 
EMTREE MEDICAL INDEX TERMS
  American Spinal Injury Association impairment scale; article; case report; cerebrospinal fluid analysis; cervical spinal cord; child; emergency ward; fever; follow up; headache; human; hydromyelia; injury severity; intensive care; lumbar puncture; male; neck pain; neurologic examination; nuclear magnetic resonance imaging; priority journal; prospective study; qualitative analysis; respiratory failure; school child; syringomyelia; thorax radiography; tracheotomy; vertebra body; vertebral canal stenosis; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013126938
MEDLINE PMID
  23411769 (http://www.ncbi.nlm.nih.gov/pubmed/23411769)
PUI
  L368405069
DOI
  10.3233/PRM-2012-00222
FULL TEXT LINK
  http://dx.doi.org/10.3233/PRM-2012-00222
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18745393&id=doi:10.3233%2FPRM-2012-00222&atitle=Diffusion+tensor+imaging+in+pediatric+transverse+myelitis%3A+A+case+study&stitle=J.+Pediatr.+Rehabit.+Med.&title=Journal+of+Pediatric+Rehabilitation+Medicine&volume=5&issue=4&spage=281&epage=286&aulast=Barakat&aufirst=Nadia&auinit=N.&aufull=Barakat+N.&coden=&isbn=&pages=281-286&date=2012&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 565
TITLE
  Successful tracheal intubation with the McGrath(®) MAC video laryngoscope 
after failure with the Pentax-AWS™ in a patient with cervical spine 
immobilization
AUTHOR NAMES
  Hyuga S.; Sekiguchi T.; Ishida T.; Yamamoto K.; Sugiyama Y.; Kawamata M.
AUTHOR ADDRESSES
  (Hyuga S.; Sekiguchi T.; Ishida T.; Yamamoto K.; Sugiyama Y.; Kawamata M., 
kawamata@shinshu-u.ac.jp) Shinshu University School of Medicine, Matsumoto, 
Japan.
CORRESPONDENCE ADDRESS
  M. Kawamata, Shinshu University School of Medicine, Matsumoto, Japan. Email: 
kawamata@shinshu-u.ac.jp
AiP/IP ENTRY DATE
  2012-09-25
FULL RECORD ENTRY DATE
  2013-07-11
SOURCE
  Canadian Journal of Anesthesia (2012) 59:12 (1154-1155). Date of 
Publication: December 2012
VOLUME
  59
ISSUE
  12
FIRST PAGE
  1154
LAST PAGE
  1155
DATE OF PUBLICATION
  December 2012
ISSN
  0832-610X
  1496-8975 (electronic)
BOOK PUBLISHER
  Springer New York, 233 Spring Street, New York, United States.
EMTREE DRUG INDEX TERMS
  oxygen (endogenous compound); propofol (intravenous drug administration); remifentanil (intravenous drug administration); rocuronium (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; laryngoscope; spine stabilization; 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesia induction; case report; cervical spine fracture (surgery); computer assisted tomography; continuous infusion; endotracheal tube; extubation; general anesthesia; human; jet ventilation; laminoplasty; laryngoscopy; letter; male; oxygen saturation; preoperative evaluation; priority journal; tracheostomy; traffic accident; treatment outcome; 
DEVICE TRADE NAMES
  McGrath MAC  , United KingdomAircraft Medical

  Pentax Airway Scope  , JapanHoya

DEVICE MANUFACTURERS
   (United Kingdom)Aircraft Medical
   (Japan)Fuji
   (Japan)Hoya
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
  propofol (2078-54-8)
  remifentanil (132539-07-2)
  rocuronium (119302-91-9)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013404327
MEDLINE PMID
  23001811 (http://www.ncbi.nlm.nih.gov/pubmed/23001811)
PUI
  L52222000
DOI
  10.1007/s12630-012-9790-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12630-012-9790-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0832610X&id=doi:10.1007%2Fs12630-012-9790-9&atitle=Successful+tracheal+intubation+with+the+McGrath%C2%AE+MAC+video+laryngoscope+after+failure+with+the+Pentax-AWS%E2%84%A2+in+a+patient+with+cervical+spine+immobilization&stitle=Can.+J.+Anesth.&title=Canadian+Journal+of+Anesthesia&volume=59&issue=12&spage=1154&epage=1155&aulast=Hyuga&aufirst=Shunsuke&auinit=S.&aufull=Hyuga+S.&coden=CJOAE&isbn=&pages=1154-1155&date=2012&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 566
TITLE
  Pre-conference workshop
AUTHOR NAMES
  Brun S.
AUTHOR ADDRESSES
  (Brun S.) Musculoskeletal and Sports Medicine, School of Medicine and 
Dentistry, James Cook University, Australia.
(Brun S.) Immediate Past President Sports Doctors Australia, Australia.
(Brun S.) SMA National Board, Australia.
CORRESPONDENCE ADDRESS
  S. Brun, Musculoskeletal and Sports Medicine, School of Medicine and 
Dentistry, James Cook University, Australia.
FULL RECORD ENTRY DATE
  2013-01-18
SOURCE
  Journal of Science and Medicine in Sport (2012) 15 SUPPL.1 (S1-S2). Date of 
Publication: December 2012
VOLUME
  15
FIRST PAGE
  S1
LAST PAGE
  S2
DATE OF PUBLICATION
  December 2012
CONFERENCE NAME
  Be Active 2012
CONFERENCE LOCATION
  Sydney, NSW, Australia
CONFERENCE DATE
  2012-10-31 to 2012-11-03
ISSN
  1440-2440
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  This fully comprehensive short course for the On-field Emergency Care of the 
seriously injured or ill athlete has been developed and accredited by Sports 
Doctors Australia. The course is also recognised and accredited by RACGP for 
category 1 QI & CPD points and rural GPs who are registered in the emergency 
component of the Rural Procedural Grants program can access this grant for 
attending this course. Given the more serious nature of sporting events and 
the greater demand for high quality and competent medical care within sport, 
the SMECC has been designed for the medical practitioner who has the 
responsibility for the care of athletes or sporting teams of all levels. The 
course focuses on the on-field management of the seriously injured and 
seriously ill athlete and involves the essential theory and will focus on 
the practical application of immediate emergency medical management and is 
designed around systems and skills stations, whereby the doctor becomes 
confident at recognising and managing serious incidents without immediate 
hospital or medical backup. 1. Each station is sport based, and focuses 
specifically on the four major systems requiring acute medical intervention. 
The systems covered and some of the skills learnt will include: Airway 
problems; a. Recognising and managing the compromised airway or an airway 
which has the potential of becoming compromised. b. Practicing the basics of 
establishing and maintaining an airway, including: Cervical spine control, 
Oxygen Therapy and appropriate delivery systems, Bag and mask resuscitation, 
inserting an oral/nasal airway, ETT and LMA insertion and needle 
cricothyroidotomy. 2. Breathing problems; a. Recognising and managing the 
athlete suffering from both medical and surgical problems of this system 
including asthma and pneumothorax. 3. Circulatory problems; b. Recognising 
and managing the shock state and the various types of shock, fluid 
resuscitation and fracture management and stabilisation. c. Identification 
and management of life threatening arrhythmias will also be addressed. 4. 
Head and spinal injuries. d. Recognising and managing the head injured 
patient including how to assess these patients, such as determining ominous 
neurological signs and how to immobilise a patient with a spinal injury. 
Each station will identify compromise and potential compromise of the system 
covered. It will also focus on essential intervention as well as certain 
contraindications to management. The stations will also emphasise the basics 
of emergency management as well as the critical advanced medical skills 
required to stabilise the seriously injured athlete. The course will then 
tie together as a complete management model so as the participant will gain 
the confidence and skills required managing the seriously injured athlete.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  workshop; 
EMTREE MEDICAL INDEX TERMS
  airway; asthma; athlete; Australia; breathing; cervical spine; disease management; emergency; emergency care; fluid resuscitation; fracture; heart arrhythmia; hospital; human; medical care; model; needle; neurologic disease; oxygen therapy; patient; physician; pneumothorax; responsibility; resuscitation; skill; spine injury; sport; sporting event; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70968105
DOI
  10.1016/j.jsams.2012.11.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jsams.2012.11.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14402440&id=doi:10.1016%2Fj.jsams.2012.11.004&atitle=Pre-conference+workshop&stitle=J.+Sci.+Med.+Sport&title=Journal+of+Science+and+Medicine+in+Sport&volume=15&issue=&spage=S1&epage=S2&aulast=Brun&aufirst=S.&auinit=S.&aufull=Brun+S.&coden=&isbn=&pages=S1-S2&date=2012&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 567
TITLE
  Workshop
AUTHOR NAMES
  Brun S.
AUTHOR ADDRESSES
  (Brun S.) Musculoskeletal and Sports Medicine, School of Medicine and 
Dentistry, James Cook University, Australia.
(Brun S.) Immediate Past President Sports Doctors Australia, Australia.
(Brun S.) SMA National Board, Australia.
CORRESPONDENCE ADDRESS
  S. Brun, Musculoskeletal and Sports Medicine, School of Medicine and 
Dentistry, James Cook University, Australia.
FULL RECORD ENTRY DATE
  2013-01-18
SOURCE
  Journal of Science and Medicine in Sport (2012) 15 SUPPL.1 (S36-S37). Date 
of Publication: December 2012
VOLUME
  15
FIRST PAGE
  S36
LAST PAGE
  S37
DATE OF PUBLICATION
  December 2012
CONFERENCE NAME
  Be Active 2012
CONFERENCE LOCATION
  Sydney, NSW, Australia
CONFERENCE DATE
  2012-10-31 to 2012-11-03
ISSN
  1440-2440
BOOK PUBLISHER
  Elsevier Ltd
ABSTRACT
  This fully comprehensive short course for the On-field Emergency Care of the 
seriously injured or ill athlete has been developed and accredited by Sports 
Doctors Australia. The course is also recognised and accredited by RACGP for 
category 1 QI & CPD points and rural GPs who are registered in the emergency 
component of the Rural Procedural Grants program can access this grant for 
attending this course. Given the more serious nature of sporting events and 
the greater demand for high quality and competent medical care within sport, 
the SMECC has been designed for the medical practitioner who has the 
responsibility for the care of athletes or sporting teams of all levels. The 
course focuses on the on-field management of the seriously injured and 
seriously ill athlete and involves the essential theory and will focus on 
the practical application of immediate emergency medicalmanagementand is 
designed around systems and skills stations, whereby the doctor becomes 
confident at recognising and managing serious incidents without immediate 
hospital or medical backup. Each station is sport based, and focuses 
specifically on the four major systems requiring acute medical intervention. 
The systems covered andsomeof the skills learnt will include: Airway 
problems; Recognising and managing the compromised airway or an airway which 
has the potential of becoming compromised. Practicing the basics of 
establishing and maintaining an airway, including: Cervical spine control, 
Oxygen Therapy and appropriate delivery systems, Bag and mask resuscitation, 
inserting an oral/nasal airway, ETT andLMAinsertion and needle 
cricothyroidotomy. Breathing problems; Recognising and managing the athlete 
suffering from both medical and surgical problems of this system including 
asthma and pneumothorax. Circulatory problems; Recognising and managing the 
shock state and the various types of shock, fluid resuscitation and fracture 
management and stabilisation. Identification and management of life 
threatening arrhythmias will also be addressed. Head and spinal injuries. 
Recognising and managing the head injured patient including how to assess 
these patients, such as determining ominous neurological signs and how to 
immobilise a patient with a spinal injury. Each station will identify 
compromise and potential compromise of the system covered. It will also 
focus on essential intervention as well as certain contraindications to 
management. The stations will also emphasise the basics of emergency 
management as well as the critical advanced medical skills required to 
stabilise the seriously injured athlete. The course will then tie together 
as a complete management model so as the participant will gain the 
confidence and skills required managing the seriously injured athlete.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  workshop; 
EMTREE MEDICAL INDEX TERMS
  airway; asthma; athlete; Australia; breathing; cervical spine; emergency; emergency care; fluid resuscitation; fracture; heart arrhythmia; hospital; human; medical care; model; needle; neurologic disease; oxygen therapy; patient; physician; pneumothorax; responsibility; resuscitation; skill; spine injury; sport; sporting event; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70968189
DOI
  10.1016/j.jsams.2012.11.089
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jsams.2012.11.089
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14402440&id=doi:10.1016%2Fj.jsams.2012.11.089&atitle=Workshop&stitle=J.+Sci.+Med.+Sport&title=Journal+of+Science+and+Medicine+in+Sport&volume=15&issue=&spage=S36&epage=S37&aulast=Brun&aufirst=S.&auinit=S.&aufull=Brun+S.&coden=&isbn=&pages=S36-S37&date=2012&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 568
TITLE
  Functional electrical stimulation: Restoration of respiratory function
AUTHOR NAMES
  Onders R.P.
AUTHOR ADDRESSES
  (Onders R.P., Raymond.onders@uhhospitals.org) University Hospitals Case 
Medical Center, Case Western Reserve University, School of Medicine, 
Cleveland, OH, United States.
CORRESPONDENCE ADDRESS
  R.P. Onders, Case Western Reserve University, School of Medicine, University 
Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 
44106-5047, United States. Email: Raymond.onders@uhhospitals.org
FULL RECORD ENTRY DATE
  2013-08-09
SOURCE
  Handbook of Clinical Neurology (2012) 109 (275-282). Date of Publication: 
2012
VOLUME
  109
FIRST PAGE
  275
LAST PAGE
  282
DATE OF PUBLICATION
  2012
ISSN
  0072-9752
BOOK PUBLISHER
  Elsevier, P.O. Box 211, Amsterdam, Netherlands.
ABSTRACT
  Tetraplegia can lead to chronic respiratory failure. The need for 
tracheostomy mechanical ventilation significantly increases the cost of 
care, decreases the quality of life of the patient, and decreases life 
expectancy in spinal cord injury (SCI) because of pneumonias. Phrenic nerve 
stimulation was initially developed in the 1960s and diaphragm pacing was 
developed in the 1990s; both have the ability to remove a patient from 
positive pressure ventilation and allow them to breathe with their own 
diaphragm, decreasing posterior lung lobe atelectasis and pneumonia risk. 
This chapter summarizes the current surgical techniques, ventilator weaning 
options, and long-term results of functional electrical stimulation in 
restoring respiratory function. © 2012 Elsevier B.V.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  convalescence; diaphragm paralysis (etiology, therapy); electrotherapy; phrenic nerve; 
EMTREE MEDICAL INDEX TERMS
  animal; article; diaphragm; human; physiology; spinal cord injury (complication); 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  23098719 (http://www.ncbi.nlm.nih.gov/pubmed/23098719)
PUI
  L365909451
DOI
  10.1016/B978-0-444-52137-8.00017-6
FULL TEXT LINK
  http://dx.doi.org/10.1016/B978-0-444-52137-8.00017-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00729752&id=doi:10.1016%2FB978-0-444-52137-8.00017-6&atitle=Functional+electrical+stimulation%3A+Restoration+of+respiratory+function&stitle=Handb.+Clin.+Neurol.&title=Handbook+of+Clinical+Neurology&volume=109&issue=&spage=275&epage=282&aulast=Onders&aufirst=Raymond+P.&auinit=R.P.&aufull=Onders+R.P.&coden=&isbn=&pages=275-282&date=2012&auinit1=R&auinitm=P
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 569
TITLE
  Surgical treatment of the lower cervical spine in patients with spinal cord 
injury
AUTHOR NAMES
  Vastmans J.; Maier D.; Vogel M.; Bühren V.; Högel F.
AUTHOR ADDRESSES
  (Vastmans J.; Maier D.; Vogel M.; Högel F.) BG Unfallklinik Murnau, 
Wirbelsäulen-und Rückenmarkverletzte, Murnau, Germany.
(Bühren V.) BG Unfallklinik Murnau, Unfallchirurgie, Murnau, Germany.
CORRESPONDENCE ADDRESS
  J. Vastmans, BG Unfallklinik Murnau, Wirbelsäulen-und Rückenmarkverletzte, 
Murnau, Germany.
FULL RECORD ENTRY DATE
  2013-01-22
SOURCE
  European Spine Journal (2012) 21:11 (2383-2384). Date of Publication: 
November 2012
VOLUME
  21
ISSUE
  11
FIRST PAGE
  2383
LAST PAGE
  2384
DATE OF PUBLICATION
  November 2012
CONFERENCE NAME
  7th German Spine Conference - Annual Meeting of the German Spine Society
CONFERENCE LOCATION
  Stuttgart, Germany
CONFERENCE DATE
  2012-12-06 to 2012-12-08
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction: Aim of this retrospective and case controlled investgation was 
to examine the treatment strategies after injuries of the cervical spine (C3 
bis T1) in patients with spinal cord injuries concerning stability of 
different stabilization techniques. Our hypothesis was that only anterior 
stabilization with cages and non-angular stable plates is sufficient 
regarding postoperative stability. Material and Methods: All patients with 
spinal cord injury and fractures of the cervical spine (C3-Th1) treated 
operatively (n= 116, mean age: 48,8 Jahre), from 01/2008 - 12/2010 were 
examined clinically and by CT scan regarding bony union and stability after 
3 and 12 months postoperatively. Results: 54 patients were treated initially 
in our clinic. 43 of these recieved anterior stabilization after 
discectomy/corpoectomy and reduction using cages and non angular stable 
plates. 7 patients sent from other hospitals were revised, 4 patients 
suffering of Bechterews'disease were treated with addiional stabilization 
from posterior. The 7 revisions were performed in he technique described 
above and 4 were treated by posterior stabilization while having an instable 
anterior stabilization and additional tracheostomy. 62 patients sent from 
other clinics were treated as following: 6 with cages and 4 with tricortical 
spill, 49 with anterior angular stable plates - 25 with cages and 24 with 
tricortical spill, 12 patients with additional posterior stabilization and 3 
only by dorsal fixation. In the postopertively performed examinations after 
3 and 12 months all of our patients were bony healed in good axial 
alignment. In 13 patients sent from other hospitals who were treated with a 
tricortical spill we found one non union; in 10 patients treated with 
angular stable plates the axis was unchanged and in 4 patients (1 
non-angular stable plate, 3 gliding plate) a kyphotic kinking was found. The 
alignment of the patients treated by anterior and additional posterior 
stabilization, as well as those patients who were treated by single 
posterior stabilization no malalignment was observed. Conclusion: Anterior 
stabilization with discectomy or corporectomy, correct reduction and 
stabilization with cages and non-angular plates leads to good stability. In 
certain cases and additional posterior stabilization is requiered. The use 
of tricortical spill sometimes leads to non-unions.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; human; patient; society; spinal cord injury; spine; surgery; 
EMTREE MEDICAL INDEX TERMS
  computer assisted tomography; discectomy; examination; fracture; hospital; hypothesis; injury; pseudarthrosis; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70969541
DOI
  10.1007/s00586-012-2522-6
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-012-2522-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-012-2522-6&atitle=Surgical+treatment+of+the+lower+cervical+spine+in+patients+with+spinal+cord+injury&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=21&issue=11&spage=2383&epage=2384&aulast=Vastmans&aufirst=J.&auinit=J.&aufull=Vastmans+J.&coden=&isbn=&pages=2383-2384&date=2012&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 570
TITLE
  Phrenic nerve stimulation as an alternative to prolonged mechanical 
ventilation
AUTHOR NAMES
  Stanley E.; Broderick J.; Synnott K.; McCarthy J.; Smith E.; Reid V.; Colreavy F.; Carton E.
AUTHOR ADDRESSES
  (Stanley E.; Broderick J.; Synnott K.; McCarthy J.; Smith E.; Reid V.; 
Colreavy F.; Carton E.) Department of Critical Care Medicine, Mater 
Misericordiae University Hospital, Dublin, Ireland.
CORRESPONDENCE ADDRESS
  E. Stanley, Department of Critical Care Medicine, Mater Misericordiae 
University Hospital, Dublin, Ireland.
FULL RECORD ENTRY DATE
  2014-02-21
SOURCE
  Irish Journal of Medical Science (2012) 181 SUPPL. 10 (S390). Date of 
Publication: November 2012
VOLUME
  181
FIRST PAGE
  S390
DATE OF PUBLICATION
  November 2012
CONFERENCE NAME
  Irish Thoracic Society Annual Scientific Meeting 2012
CONFERENCE LOCATION
  Limerick, Ireland
CONFERENCE DATE
  2012-11-23 to 2012-11-24
ISSN
  0021-1265
BOOK PUBLISHER
  Springer London
ABSTRACT
  A 60 year old previously well male patient sustained a C2 traumatic spinal 
cord injury after a fall from a horse. He remained on full time ventilatory 
support via tracheostomy tube. After the integrity of the phrenic nerve was 
confirmed, internal components of the phrenic nerve stimulator (PNS) were 
surgically implanted. The duration of PNS breathing was gradually increased 
with the tracheostomy tube capped to facilitate normal humidification of 
inspired room air and normal voice during passive exhalation. He could 
operate his motorised wheelchair with his chin, tolerated normal diet by 
mouth and had a prolonged period free of lower respiratory tract 
infections..
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; nerve stimulation; phrenic nerve; society; 
EMTREE MEDICAL INDEX TERMS
  ambient air; breathing; chin; diet; exhalation; horse; human; humidifier; lower respiratory tract infection; male; nerve stimulator; patient; spinal cord injury; tracheostomy tube; voice; wheelchair; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71326117
DOI
  10.1007/s11845-012-0856-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s11845-012-0856-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00211265&id=doi:10.1007%2Fs11845-012-0856-z&atitle=Phrenic+nerve+stimulation+as+an+alternative+to+prolonged+mechanical+ventilation&stitle=Ir.+J.+Med.+Sci.&title=Irish+Journal+of+Medical+Science&volume=181&issue=&spage=S390&epage=&aulast=Stanley&aufirst=E.&auinit=E.&aufull=Stanley+E.&coden=&isbn=&pages=S390-&date=2012&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 571
TITLE
  Cervical spine trauma in diffuse idiopathic skeletal hyperostosis: Injury 
characteristics and outcome with surgical treatment
AUTHOR NAMES
  Bransford R.J.; Koller H.; Caron T.; Zenner J.; Hitzl W.; Tomasino A.; Mayer M.
AUTHOR ADDRESSES
  (Bransford R.J., rbransfo@uw.edu) Department of Orthopaedics and Sports 
Medicine, Harborview Medical Center, University of Washington Medical 
Center, 325 9th Ave., Seattle, WA 98104, United States.
(Koller H.; Zenner J.) German Scoliosis Center, Werner-Wicker-Klinik, Bad 
Wildungen, Germany.
(Koller H.; Mayer M.) Department for Traumatology and Sports Injuries, 
Paracelsus Medical University, Salzburg, Austria.
(Caron T.) Saint John's Regional Medical Center, Springfield, MO, United 
States.
(Hitzl W.) Research Office, Biostatistics, Paracelsus Medical University, 
Salzburg, Austria.
(Tomasino A.) Department of Neurological Surgery, New York Presbyterian 
Hospital, Cornell Medical College, New York, NY, United States.
CORRESPONDENCE ADDRESS
  R.J. Bransford, Department of Orthopaedics and Sports Medicine, Harborview 
Medical Center, University of Washington Medical Center, 325 9th Ave., 
Seattle, WA 98104, United States. Email: rbransfo@uw.edu
AiP/IP ENTRY DATE
  2012-05-07
FULL RECORD ENTRY DATE
  2012-11-21
SOURCE
  Spine (2012) 37:23 (1923-1932). Date of Publication: 1 Nov 2012
VOLUME
  37
ISSUE
  23
FIRST PAGE
  1923
LAST PAGE
  1932
DATE OF PUBLICATION
  1 Nov 2012
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  STUDY DESIGN.: Retrospective study of a consecutive series of operatively 
managed patients with cervical fractures with diffuse idiopathic skeletal 
hyperostosis (DISH) presenting to 3 institutions over an 8 year period. 
OBJECTIVE.: Assess demographics, fracture characteristics, outcome and 
complications in patients managed surgically. SUMMARY OF BACKGROUND DATA.: 
Cervical spine injuries related to DISH represent a difficult subgroup of 
trauma patients to treat. This subset is fraught with potential 
complications related to the injury of the ankylosed spine, high rate of 
co-morbidities, and older demographics. The data in the literature on 
treatment, outcomes and complications is largely comprised of case reports 
and small case series. METHODS.: All patients with cervical fractures in the 
setting of DISH between January 2001 and December 2008 were reviewed 
retrospectively. Charts and radiographs were reviewed assessing 
demographics, injury characteristics and short-term outcomes. Statistical 
analysis was performed analyzing the impact of distinct parameters on the 
incidence of medical and surgical complications. RESULTS.: Thirty-three 
patients with age 73.8 ± 11years were identified. DISH-affected segments 
numbered 5.5 ± 2.1. Injury severity as assessed by the 
Subaxial-Injury-Classification scoring-system (SLIC) averaged 7.2 ± 
1.4points. 7 patients (20.6%) were ASIA-A on admission, 4 (11.8%) ASIA-B, 4 
(11.8%) ASIA-C, 10 (29.4%) ASIA-D, and 7 (20.6%) ASIA-E. All but 2 patients 
(6%) had medical co-morbidities.Inpatient stay was 26.6 ± 23.4 days. 16 
patients (47%) had anterior, 12 patients (35.3%) had posterior, and 5 
patients (14.7%) had combined anterior-posterior instrumented fusion. 25 
patients (73.5%) had medical/surgical complications. 20 patients (58.8%) 
suffered serious pulmonary complications not related to the neurologic 
injury (p < 0.05). Nine patients (26.5%) had died. Seven patients (20.6%) 
showed improved ASIA-scores, 18 patients (52.9%) had no improvement and 2 
patients (5.9%) deteriorated. CONCLUSION.: The current findings pinpoint the 
potential for medical and surgical complications in this high risk subgroup. 
Surgeons should be aware of the unique aspects associated with treatment of 
these injuries. © 2012, Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture (surgery); diffuse idiopathic skeletal hyperostosis; hyperostosis; idiopathic disease; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; anterior spine fusion; artificial ventilation; cervical spine radiography; clinical article; clinical feature; comorbidity; decubitus (complication); deep vein thrombosis; delirium (complication); deterioration; dysphagia (complication); female; hospital admission; human; injury severity; intubation; length of stay; lung complication (complication); male; medical record review; mortality; neurological complication (complication); outcome assessment; pneumonia (complication); posterior spine fusion; postoperative complication (complication); priority journal; retrospective study; review; scoring system; surgical infection (complication); tracheostomy; urinary tract infection (complication); 
EMBASE CLASSIFICATIONS
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012657886
MEDLINE PMID
  22543253 (http://www.ncbi.nlm.nih.gov/pubmed/22543253)
PUI
  L51982472
DOI
  10.1097/BRS.0b013e31825b17fc
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e31825b17fc
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e31825b17fc&atitle=Cervical+spine+trauma+in+diffuse+idiopathic+skeletal+hyperostosis%3A+Injury+characteristics+and+outcome+with+surgical+treatment&stitle=Spine&title=Spine&volume=37&issue=23&spage=1923&epage=1932&aulast=Bransford&aufirst=Richard+J.&auinit=R.J.&aufull=Bransford+R.J.&coden=SPIND&isbn=&pages=1923-1932&date=2012&auinit1=R&auinitm=J
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 572
TITLE
  Risk factors for heterotopic ossification in patients with spinal cord 
injury: A case-control study of 264 patients
AUTHOR NAMES
  Citak M.; Suero E.M.; Backhaus M.; Aach M.; Godry H.; Meindl R.; Schildhauer T.A.
AUTHOR ADDRESSES
  (Citak M., mcitak@gmx.de; Backhaus M.; Godry H.; Schildhauer T.A.) 
Department of General and Trauma Surgery, BG University Hospital 
Bergmannsheil, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 
Bochum, Germany.
(Suero E.M.) Department of Orthopaedic Surgery, Hospital for Special 
Surgery, New York, NY, United States.
(Aach M.; Meindl R.) Division of Spinal Cord Injury, BG University Hospital 
Bergmannsheil, Ruhr-University Bochum, Germany.
CORRESPONDENCE ADDRESS
  M. Citak, Department of General and Trauma Surgery, BG University Hospital 
Bergmannsheil, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 
Bochum, Germany. Email: mcitak@gmx.de
AiP/IP ENTRY DATE
  2012-05-25
FULL RECORD ENTRY DATE
  2012-11-21
SOURCE
  Spine (2012) 37:23 (1953-1957). Date of Publication: 1 Nov 2012
VOLUME
  37
ISSUE
  23
FIRST PAGE
  1953
LAST PAGE
  1957
DATE OF PUBLICATION
  1 Nov 2012
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  STUDY DESIGN.: Case-control study. OBJECTIVE.: We designed a case-control 
study to analyze the risk factors associated with the development of 
heterotopic ossification (HO) in patients with traumatic spinal cord injury. 
SUMMARY OF BACKGROUND DATA.: Patients with spinal cord injury have a high 
risk of developing HO, although the exact etiopathogenesis is still unknown. 
Several factors are known to be potential risk factors. However, we are not 
aware of any large clinical studies evaluating the risk factors for HO. 
METHODS.: Patients who were treated for a traumatic spinal cord injury in 
our hospital, and who subsequently developed HO, were identified by querying 
the electronic database at our hospital from 2002 to 2010. One hundred 
thirty-two patients and 132 controls were included. Our primary outcome 
measures were the risk of developing HO according to whether the patient had 
experienced a complete spinal cord lesion according to American Spinal 
Injury Association Impairment Scale; tetraplegia or paraplegia; cervical, 
thoracic, or lumbar injury; severe chest trauma; and the time interval 
between injury and surgery. Secondary risk factors explored were patient 
age; sex; presence and number of comorbidities; length of hospital and 
intensive care unit stay; associated traumatic injuries; presence of 
spasticity, pressure ulcers, deep venous thrombosis, and urinary tract 
infection; and pulmonary complications, such as pneumonia and necessity of 
tracheostomy. RESULTS.: Patients with associated spasticity and thoracic 
trauma, complete lesion, pneumonia, presence of tracheostomy, and urinary 
tract infection had a higher risk of developing HO. CONCLUSION.: Adequate 
management of potential risk factors could help reduce the overall incidence 
of HO and outcome in patients with traumatic spinal cord injury. © 2012, 
Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  heterotopic ossification (complication); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  abdominal injury; adult; age; article; brain injury; case control study; cervical spine injury; comorbidity; controlled study; decubitus; female; gender; head injury; human; intensive care unit; length of stay; limb injury; lumbar spine; lung complication (complication); major clinical study; male; outcome assessment; paraplegia; pelvis injury; pneumonia (complication); priority journal; quadriplegia; risk assessment; risk factor; spasticity; thoracic spine; thorax injury; tracheostomy; urinary tract infection; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012657889
MEDLINE PMID
  22614800 (http://www.ncbi.nlm.nih.gov/pubmed/22614800)
PUI
  L52020604
DOI
  10.1097/BRS.0b013e31825ee81b
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e31825ee81b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e31825ee81b&atitle=Risk+factors+for+heterotopic+ossification+in+patients+with+spinal+cord+injury%3A+A+case-control+study+of+264+patients&stitle=Spine&title=Spine&volume=37&issue=23&spage=1953&epage=1957&aulast=Citak&aufirst=Mustafa&auinit=M.&aufull=Citak+M.&coden=SPIND&isbn=&pages=1953-1957&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 573
TITLE
  Nonaneurysmal cerebellar subarachnoid haemorrhage as rare complication of 
lumbar disc surgery
AUTHOR NAMES
  Knoop M.; Allen C.
AUTHOR ADDRESSES
  (Knoop M.; Allen C.) HELIOS Klinikum Bad Saarow, Neurochirurgie, Bad Saarow, 
Germany.
CORRESPONDENCE ADDRESS
  M. Knoop, HELIOS Klinikum Bad Saarow, Neurochirurgie, Bad Saarow, Germany.
FULL RECORD ENTRY DATE
  2013-01-22
SOURCE
  European Spine Journal (2012) 21:11 (2350). Date of Publication: November 
2012
VOLUME
  21
ISSUE
  11
FIRST PAGE
  2350
DATE OF PUBLICATION
  November 2012
CONFERENCE NAME
  7th German Spine Conference - Annual Meeting of the German Spine Society
CONFERENCE LOCATION
  Stuttgart, Germany
CONFERENCE DATE
  2012-12-06 to 2012-12-08
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction: The rates of intraoperative dural tear range from 3.5 % for 
primary lumbar discectomy to over 10 % for lumbar revision discectomy. Most 
of the reported cases of intracranial haemorrhage after spinal surgery 
involved intraoperative dural tearing or cerebrospinal fluid (CSF) leakage. 
We report a case in which nonaneurysmal cerebellar subarachnoid haemorrhage 
after occurred lumbar revision discectomy and review the literature. 
Material and Methods: A 70-year-old man with a history of smoking and 
adipositas presented clinical signs and symptoms and MR imaging studies 
consistent with a reherniated nucleus pulposus at the L4-L5 disc space. He 
underwent a lumbar revision discectomy. Intraoperatively, an incidental 
durotomy occurred and was repaired uneventfully. One closed suction drain 
was placed subfascial. Shortly after extubation the patient had a reduced 
level of consciousness. Two hours postoperatively, the drain had drawn 250 
ml clear fluid tinged with blood, consistent with CSF. The man developed 
severe headache, and lost consciousness. The emergency computed tomographic 
scan showed an atypical cerebellar subarachnoid haemorrhage in the sulci as 
well as haematom of cortex of both cerebellar hemispheres. Haemorrhage and 
edema led to compression of the fourth ventricle and subsequent 
non-communicating hydrocephalus. The subfascial wound drain was removed. The 
patient was immediately transferred to the operation room for external 
ventricular drain and suboccipital decompression. Angiography did not reveal 
the focus of bleeding. Tracheotomy was performed. Concomitantly, the patient 
developed pneumonia, Clostridium difficile associated diarrhea, meningitis 
and epileptic seizures as well as a coagulation disorder. Over the next 
weeks the patients state of consciousness improved. Five weeks 
postoperatively, the man was transferred to a rehabilitation department, two 
months later he died there. Conclusion: The reported case adds to the 
literature on complication in lumbar disc surgery. Nonaneurysmal cerebellar 
subarachnoid haemorrhage is a rare but potentially lethal complication of 
lumbar disc surgery. The postoperative CSF loss as a possible mechanism for 
this cerebellar subarachnoid haemorrhage. Preventing dural injury during 
spinal surgery, dural repair and minimizing CSF loss after intraoperative 
dural tearing, especially during suction drain, would be helpful to prevent 
cerebellar subarachnoid haemorrhage.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lumbar disk; society; spine; subarachnoid hemorrhage; surgery; 
EMTREE MEDICAL INDEX TERMS
  angiography; bleeding; blood; blood clotting disorder; brain fourth ventricle; brain hemorrhage; cerebrospinal fluid; Clostridium difficile infection; communicating hydrocephalus; compression; computer assisted tomography; consciousness; decompression; discectomy; edema; emergency; extubation; headache; hemisphere; human; injury; lacrimal fluid; liquid; liquorrhea; male; meningitis; nuclear magnetic resonance imaging; nucleus pulposus; obesity; operating room; patient; physical disease by body function; pneumonia; rehabilitation center; seizure; smoking; spine surgery; suction drainage; tracheotomy; wound drain; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70969460
DOI
  10.1007/s00586-012-2522-6
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-012-2522-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-012-2522-6&atitle=Nonaneurysmal+cerebellar+subarachnoid+haemorrhage+as+rare+complication+of+lumbar+disc+surgery&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=21&issue=11&spage=2350&epage=&aulast=Knoop&aufirst=M.&auinit=M.&aufull=Knoop+M.&coden=&isbn=&pages=2350-&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 574
TITLE
  Diaphragmatic pacing stimulation in spinal cord injury: Anesthetic and 
perioperative management
AUTHOR NAMES
  Tedde M.L.; Filho P.V.; Hajjar L.A.; de Almeida J.P.; Flora G.F.; Okumura E.M.; Osawa E.A.; Fukushima J.T.; Teixeira M.J.; Galas F.R.B.G.; Jatene F.B.; Auler Jr. J.O.C.
AUTHOR ADDRESSES
  (Tedde M.L., tedde@usp.br; Flora G.F.; Okumura E.M.; Jatene F.B.) Hospital 
das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Heart 
Institute (InCor), Thoracic Surgery Department, São Paulo/SP, Brazil.
(Filho P.V.; Hajjar L.A.; de Almeida J.P.; Osawa E.A.; Fukushima J.T.; Galas 
F.R.B.G.; Auler Jr. J.O.C.) Hospital das Clínicas da Faculdade de Medicina 
da Universidade de São Paulo, Heart Institute (InCor), Anaesthesia and 
Surgical Intensive Care Unit, Heart Institute (InCor), São Paulo/SP, Brazil.
(Teixeira M.J.) Hospital das Clínicas da Faculdade de Medicina da 
Universidade de São Paulo, Department of Neurosurgery, Laboratory of 
Experimental Surgery (LIM26), São Paulo/SP, Brazil.
CORRESPONDENCE ADDRESS
  M. L. Tedde, Hospital das Clínicas da Faculdade de Medicina da Universidade 
de São Paulo, Heart Institute (InCor), Thoracic Surgery Department, São 
Paulo/SP, Brazil. Email: tedde@usp.br
FULL RECORD ENTRY DATE
  2013-08-03
SOURCE
  Clinics (2012) 67:11 (1265-1269). Date of Publication: November 2012
VOLUME
  67
ISSUE
  11
FIRST PAGE
  1265
LAST PAGE
  1269
DATE OF PUBLICATION
  November 2012
ISSN
  1807-5932
BOOK PUBLISHER
  Universidade de Sao Paulo, Av.Dr.Arnaldo 455-Cerqueira Cesar, Sao Paulo, 
Brazil.
ABSTRACT
  OBJECTIVE: The standard therapy for patients with high-level spinal cord 
injury is long-term mechanical ventilation through a tracheostomy. However, 
in some cases, this approach results in death or disability. The aim of this 
study is to highlight the anesthetics and perioperative aspects of patients 
undergoing insertion of a diaphragmatic pacemaker. METHODS: Five patients 
with quadriplegia following high cervical traumatic spinal cord injury and 
ventilatordependent chronic respiratory failure were implanted with a 
laparoscopic diaphragmatic pacemaker after preoperative assessments of their 
phrenic nerve function and diaphragm contractility through transcutaneous 
nerve stimulation. ClinicalTrials.gov: NCT01385384. RESULTS: The 
diaphragmatic pacemaker placement was successful in all of the patients. Two 
patients presented with capnothorax during the perioperative period, which 
resolved without consequences. After six months, three patients achieved 
continuous use of the diaphragm pacing system, and one patient could be 
removed from mechanical ventilation for more than 4 hours per day. 
CONCLUSIONS: The implantation of a diaphragmatic phrenic system is a new and 
safe technique with potential to improve the quality of life of patients who 
are dependent on mechanical ventilation because of spinal cord injuries. 
Appropriate indication and adequate perioperative care are fundamental to 
achieving better results. © 2012 CLINICS.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; artificial heart pacemaker; artificial ventilation; diaphragm; electrotherapy; implantation; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; controlled clinical trial; controlled study; female; human; laparoscopy; male; methodology; perioperative period; quadriplegia (therapy); time; treatment outcome; 
CLINICAL TRIAL NUMBERS
  ClinicalTrials.gov (NCT01385384)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  23184201 (http://www.ncbi.nlm.nih.gov/pubmed/23184201)
PUI
  L366181680
DOI
  10.6061/clinics/2012(11)07
FULL TEXT LINK
  http://dx.doi.org/10.6061/clinics/2012(11)07
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18075932&id=doi:10.6061%2Fclinics%2F2012%2811%2907&atitle=Diaphragmatic+pacing+stimulation+in+spinal+cord+injury%3A+Anesthetic+and+perioperative+management&stitle=Clinics&title=Clinics&volume=67&issue=11&spage=1265&epage=1269&aulast=Tedde&aufirst=Miguel+L.&auinit=M.L.&aufull=Tedde+M.L.&coden=&isbn=&pages=1265-1269&date=2012&auinit1=M&auinitm=L
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 575
TITLE
  Congenital paediatric atlantoaxial dislocation: Clinico-radiological profile 
and surgical outcome
AUTHOR NAMES
  Mehrotra A.; Nair A.P.; Das K.; Chunnilal J.S.; Srivastava A.K.; Sahu R.; Kumar R.
AUTHOR ADDRESSES
  (Mehrotra A.; Nair A.P.; Das K.; Chunnilal J.S.; Srivastava A.K.; Sahu R.; 
Kumar R., rajkumar1959@gmail.com) Sanjay Gandhi Postgraduate Institute of 
Medical Sciences (SGPGIMS), Lucknow 226014, India.
(Kumar R., rajkumar1959@gmail.com) Department of Neurosurgery, Trauma 
Centre, S.G.P.G.I.M.S, Lucknow-14, India.
CORRESPONDENCE ADDRESS
  R. Kumar, Department of Neurosurgery, Trauma Centre, S.G.P.G.I.M.S, 
Lucknow-14, India. Email: rajkumar1959@gmail.com
AiP/IP ENTRY DATE
  2012-06-01
FULL RECORD ENTRY DATE
  2012-10-28
SOURCE
  Child's Nervous System (2012) 28:11 (1943-1950). Date of Publication: 
November 2012
VOLUME
  28
ISSUE
  11
FIRST PAGE
  1943
LAST PAGE
  1950
DATE OF PUBLICATION
  November 2012
ISSN
  0256-7040
  1433-0350 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Introduction Congenital atlantoaxial dislocation (AAD) is the most common 
bony abnormality affecting the craniovertebral junction. The paediatric 
population has specific problems like preoperative diagnostic difficulties, 
precise neurological examination, radiological diagnosis, surgical problems 
including physical fitness to tolerate surgery (including problems of 
anaesthesia), technical difficulties in surgery and problems related to 
immobilization Material and methods A total of 229 consecutive paediatric 
(≤18 years) patients of AAD visited our centre from the period of January 
1997 to August 2011. Twenty-nine cases were excluded from the study as these 
cases were diagnosed as CVJ tuberculosis, 31 cases were excluded as they 
were traumatic and the remaining 169 cases were retrospectively analysed. 
These patients were operated by a single experienced surgeon (the senior 
author) at the Sanjay Gandhi Post Graduate Institute of Medical Sciences, 
Lucknow. The preoperative and the postoperative clinical evaluation of the 
patient was done by the Kumar and Kalra myelopathic scoring system. The 
score was recorded in the preoperative period, at the time of discharge, at 
3 months follow-up and at 6 months follow-up. Results Ninety-four were males 
and 75 were females. The age range was 4 to 18 years with mean age 9.96±3.78 
years. The follow-up ranged from 3 to 120 months with mean follow-up being 
39.03±13.38 months. One hundred five cases were of fixed/irreducible AAD, 
and 64 were cases of mobile/reducible AAD. Majority of these cases presented 
with features of pyramidal tract involvement, and 108 cases had compromised 
pulmonary function test. One hundred thirty-seven cases had improved 
outcome, and 18 cases were in the same grade in the postoperative period 
with only 14 cases either deteriorated or died. Conclusions Congenital 
paediatric AAD are a different subset of abnormalities and have a 
satisfactory outcome. Preoperative evaluation must also include 
identification of various syndromes associated with paediatric AAD and 
respiratory reserve. Cormack-Lehane grade can be helpful in selecting 
borderline cases for postoperative need of tracheostomy. Majority of the 
cases have a good outcome, and therefore, surgery should be offered even in 
severe grade. © Springer-Verlag 2012.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial dislocation (congenital disorder, surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; child; clinical feature; female; follow up; human; immobilization; Kumar and Kalra myelopathic scoring system; lung function test; major clinical study; male; postoperative period; preoperative period; preschool child; priority journal; retrospective study; school child; scoring system; treatment outcome; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012608717
MEDLINE PMID
  22645063 (http://www.ncbi.nlm.nih.gov/pubmed/22645063)
PUI
  L52034794
DOI
  10.1007/s00381-012-1801-1
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-012-1801-1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-012-1801-1&atitle=Congenital+paediatric+atlantoaxial+dislocation%3A+Clinico-radiological+profile+and+surgical+outcome&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=28&issue=11&spage=1943&epage=1950&aulast=Mehrotra&aufirst=&auinit=A.&aufull=Mehrotra+A.&coden=CNSYE&isbn=&pages=1943-1950&date=2012&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 576
TITLE
  Mechanical airway obstruction due to dislodged spinal hardware
AUTHOR NAMES
  Petrovic M.A.; Kretzer R.; Simon B.A.; Berkow L.C.
AUTHOR ADDRESSES
  (Petrovic M.A.; Berkow L.C., Lberkow1@jhmi.edu) Department of Anesthesia and 
Critical Care Medicine, Johns Hopkins School of Medicine, 600 North Wolfe 
St., Meyer 8-134, Baltimore, MD 21287, United States.
(Kretzer R.) Department of Neurological Surgery, Johns Hopkins School of 
Medicine, Baltimore, MD 21287, United States.
(Simon B.A.) Department of Anesthesia, Critical Care and Pain Medicine, Beth 
Israel Deaconess Medical Center, Boston, MA 02215, United States.
CORRESPONDENCE ADDRESS
  L.C. Berkow, Department of Anesthesia and Critical Care Medicine, Johns 
Hopkins School of Medicine, 600 North Wolfe St., Meyer 8-134, Baltimore, MD 
21287, United States. Email: Lberkow1@jhmi.edu
AiP/IP ENTRY DATE
  2012-10-31
FULL RECORD ENTRY DATE
  2012-11-02
SOURCE
  Journal of Clinical Anesthesia (2012) 24:7 (578-581). Date of Publication: 
November 2012
VOLUME
  24
ISSUE
  7
FIRST PAGE
  578
LAST PAGE
  581
DATE OF PUBLICATION
  November 2012
ISSN
  0952-8180
  1873-4529 (electronic)
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  A difficult airway caused by mechanical obstruction from dislodged spinal 
hardware in a patient undergoing revision surgery for a cervical chordoma is 
presented. Due to the logical, sequential multidisciplinary airway and 
patient management by the anesthesiology, neurosurgery, and otolaryngology 
teams working together in an environment of clear communication, a potential 
life-threatening crisis was averted with successful outcome for the patient. 
© 2012 Elsevier Inc.
EMTREE DRUG INDEX TERMS
  ketamine; midazolam; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction; cervical hardware; medical device; prosthesis complication; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; chordoma; computer assisted tomography; fiberoptic intubation; human; intubation; male; neurosurgery; priority journal; spine radiography; spine tumor; tracheostomy; 
CAS REGISTRY NUMBERS
  ketamine (1867-66-9, 6740-88-1, 81771-21-3)
  midazolam (59467-70-8)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012622905
MEDLINE PMID
  23101773 (http://www.ncbi.nlm.nih.gov/pubmed/23101773)
PUI
  L365904654
DOI
  10.1016/j.jclinane.2012.03.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jclinane.2012.03.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09528180&id=doi:10.1016%2Fj.jclinane.2012.03.002&atitle=Mechanical+airway+obstruction+due+to+dislodged+spinal+hardware&stitle=J.+Clin.+Anesth.&title=Journal+of+Clinical+Anesthesia&volume=24&issue=7&spage=578&epage=581&aulast=Petrovic&aufirst=Michelle+A.&auinit=M.A.&aufull=Petrovic+M.A.&coden=JCLBE&isbn=&pages=578-581&date=2012&auinit1=M&auinitm=A
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 577
TITLE
  Endoscopic endonasal odontoidectomy in a child with chronic type 3 
atlantoaxial rotatory fixation: Case report and literature review
AUTHOR NAMES
  Patel A.J.; Boatey J.; Muns J.; Bollo R.J.; Whitehead W.E.; Giannoni C.M.; Jea A.
AUTHOR ADDRESSES
  (Patel A.J.; Boatey J.; Muns J.; Jea A., ajea@bcm.edu) Neuro-Spine Program, 
Department of Neurosurgery, Baylor College of Medicine, 6621 Fannin Street 
CCC 1230.01, Houston, TX 77030, United States.
(Patel A.J.; Bollo R.J.; Whitehead W.E.) Endoscopic Skull Base Program, 
Department of Neurosurgery, Baylor College of Medicine, Houston, TX, United 
States.
(Giannoni C.M.) Division of Pediatric Otolaryngology, Department of 
Otolaryngology, Baylor College of Medicine, Houston, TX, United States.
CORRESPONDENCE ADDRESS
  A. Jea, Neuro-Spine Program, Department of Neurosurgery, Baylor College of 
Medicine, 6621 Fannin Street CCC 1230.01, Houston, TX 77030, United States. 
Email: ajea@bcm.edu
AiP/IP ENTRY DATE
  2012-07-09
FULL RECORD ENTRY DATE
  2012-10-28
SOURCE
  Child's Nervous System (2012) 28:11 (1971-1975). Date of Publication: 
November 2012
VOLUME
  28
ISSUE
  11
FIRST PAGE
  1971
LAST PAGE
  1975
DATE OF PUBLICATION
  November 2012
ISSN
  0256-7040
  1433-0350 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Introduction Although the transoral transpharyngeal approach has been the 
standard approach to decompress the odontoid process, it bears some 
disadvantages including risk of infection, prolonged intubation or 
tracheostomy, need for nasogastric tube feeding, extended hospitalization, 
and possible effects of phonation. The endoscopic transnasal approach is a 
viable alternative, managing to avoid some of the pitfalls of the more 
accepted transoral transpharyngeal approach. However, there have only been a 
handful of adult cases and only three pediatric cases Case report We present 
the case of a 10-year-old girl with a chronic type 3 atlantoaxial rotator 
fixation and significant spinal cord compression from basilar invagination 
and a displaced odontoid process. We performed an endoscopic endonasal 
odontoidectomy prior to posterior occiptocervical fusion on the patient. She 
was neurologically intact with a well-healed wound at 7-month follow-up. © 
Springer-Verlag 2012.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial rotatory fixation (surgery); atlantoaxial subluxation (surgery); chronic disease (surgery); endoscopic endonasal odontoidectomy; endoscopic surgery; pediatric surgery; 
EMTREE MEDICAL INDEX TERMS
  bone radiography; case report; child; computer assisted tomography; decompression surgery; female; fluoroscopy; follow up; fracture fixation; human; laminectomy; motor evoked potential; open reduction (procedure); priority journal; review; school child; somatosensory evoked potential; spinal cord compression (surgery); spine fusion; surgical approach; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012608722
MEDLINE PMID
  22763656 (http://www.ncbi.nlm.nih.gov/pubmed/22763656)
PUI
  L52097378
DOI
  10.1007/s00381-012-1818-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-012-1818-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-012-1818-5&atitle=Endoscopic+endonasal+odontoidectomy+in+a+child+with+chronic+type+3+atlantoaxial+rotatory+fixation%3A+Case+report+and+literature+review&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=28&issue=11&spage=1971&epage=1975&aulast=Patel&aufirst=Akash+J.&auinit=A.J.&aufull=Patel+A.J.&coden=CNSYE&isbn=&pages=1971-1975&date=2012&auinit1=A&auinitm=J
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 578
TITLE
  Predicting the need for tracheostomy in patients with cervical spinal cord 
injury
AUTHOR NAMES
  Leelapattana P.; Fleming J.C.; Gurr K.R.; Bailey S.I.; Parry N.; Bailey C.S.
AUTHOR ADDRESSES
  (Leelapattana P.; Fleming J.C.; Gurr K.R.; Bailey S.I.; Bailey C.S., 
chris.bailey@lhsc.on.ca) Department of Surgery, Schulich School of Medicine, 
Western University, London, ON, Canada.
(Leelapattana P.; Fleming J.C.; Gurr K.R.; Bailey S.I.; Bailey C.S., 
chris.bailey@lhsc.on.ca) Orthopaedic Spine Program, Victoria Hospital, 
London Health Science Centre, 800 Commissioners Road East, E4 120, London, 
ON N6A 5W9, Canada.
(Parry N.) Division of General Surgery and Critical Care, Schulich School of 
Medicine, University of Western Ontario, London, ON, Canada.
(Parry N.) Department of Surgery and Medicine, Schulich School of Medicine, 
University of Western Ontario, London, ON, Canada.
(Parry N.) Trauma Program, Victoria Hospital, London Health Sciences Centre, 
London, ON, Canada.
CORRESPONDENCE ADDRESS
  C.S. Bailey, Orthopaedic Spine Program, Victoria Hospital, London Health 
Science Centre, 800 Commissioners Road East, E4 120, London, ON N6A 5W9, 
Canada. Email: chris.bailey@lhsc.on.ca
AiP/IP ENTRY DATE
  2012-06-07
FULL RECORD ENTRY DATE
  2012-10-16
SOURCE
  Journal of Trauma and Acute Care Surgery (2012) 73:4 (880-884). Date of 
Publication: October 2012
VOLUME
  73
ISSUE
  4
FIRST PAGE
  880
LAST PAGE
  884
DATE OF PUBLICATION
  October 2012
ISSN
  2163-0755
  2163-0763 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  BACKGROUND: Approximately 75% of hospitalized patients with a cervical 
spinal cord injury (CSCI) will require intubation and mechanical ventilation 
(MV) because of compromised respiratory function. It is difficult to predict 
those CSCI patients who will require prolonged ventilation and therefore 
will most benefit from early tracheostomy. This study intended to show the 
benefits of tracheostomy, particularly early, and to identify predictors of 
prolonged MV after CSCI. METHODS: A retrospective review of patients aged 16 
years and older with acute CSCI admitted to London Health Science Center 
from 1991 to 2010 was performed. Demographic data and clinical parameters 
were extracted from medical records and the trauma registry. Regression 
analysis was used to identify predictors of prolonged MV. RESULTS: There 
were 66 eligible patients of which 42 (62%) had a tracheostomy performed. 
Five patients (7.6%) remained ventilator dependent and seven (10.6%) died 
more than 7 days after injury secondary to sepsis. After adjusting for the 
number of ventilator days after injury, patients who had a tracheostomy had 
fewer pulmonary complications than those who did not have a tracheostomy (p 
= 0.001). Early tracheostomy resulted in fewer days on the ventilator and a 
shorter hospital stay. Clinical parameters that predicted MV to be required 
longer than 7 days were Injury Severity Score > 32, complete SCI, and a 
PAO2/FIO2 ratio < 300 3 days after MV was initiated. CONCLUSION: We 
recommend early tracheostomy if the Injury Severity Score is >32, the 
patient has a complete SCI, and the PAO2/FIO2 ratio is <300 3 days after MV 
was initiated. LEVEL OF EVIDENCE: Prognostic study, level III. © 2012 
Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; controlled study; disease registry; female; hospitalization; human; injury scale; lung complication; major clinical study; male; medical record review; prediction; priority journal; scoring system; sepsis; ventilator; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012582025
MEDLINE PMID
  22710778 (http://www.ncbi.nlm.nih.gov/pubmed/22710778)
PUI
  L52039941
DOI
  10.1097/TA.0b013e318251fb34
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e318251fb34
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=21630755&id=doi:10.1097%2FTA.0b013e318251fb34&atitle=Predicting+the+need+for+tracheostomy+in+patients+with+cervical+spinal+cord+injury&stitle=J.+Trauma+Acute+Care+Surg.&title=Journal+of+Trauma+and+Acute+Care+Surgery&volume=73&issue=4&spage=880&epage=884&aulast=Leelapattana&aufirst=Pittavat&auinit=P.&aufull=Leelapattana+P.&coden=&isbn=&pages=880-884&date=2012&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 579
TITLE
  Benefits of performing early tracheostomy in the intensive care unit of a 
secondary level hospital of north india, our two years experiences
AUTHOR NAMES
  Dhanda D.; Dhanda N.C.
AUTHOR ADDRESSES
  (Dhanda D.) Columbiaasia Hospital, Anesthesia/Critical Care, Patiala, India.
(Dhanda N.C.) Columbiaasia Hospital, Ophthalmology, Patiala, India.
CORRESPONDENCE ADDRESS
  D. Dhanda, Columbiaasia Hospital, Anesthesia/Critical Care, Patiala, India.
FULL RECORD ENTRY DATE
  2013-03-20
SOURCE
  Intensive Care Medicine (2012) 38 SUPPL. 1 (S162). Date of Publication: 
October 2012
VOLUME
  38
FIRST PAGE
  S162
DATE OF PUBLICATION
  October 2012
CONFERENCE NAME
  25th Annual Congress of the European Society of Intensive Care Medicine, 
ESICM 2012
CONFERENCE LOCATION
  Lisbon, Portugal
CONFERENCE DATE
  2012-10-13 to 2012-10-17
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  INTRODUCTION. In most of the intensive care units tracheostomy is being 
performed on many patients who needs long term ventilatory support. The 
patients always do get benefited after the tracheostomy. Though there is 
always debate about the timing of tracheostomy and technique of procedure. 
OBJECTIVES. To find out the benefits of performing early tracheostomy in the 
intensive care unit on the patients requiring long term ventilatory support. 
METHODS. The study was conducted in 14 bedded intensive care unit of 
secondary level hospital in India over a period of 2 years (from April 2010 
to March 2012). Total of 64 tracheostomies were performed over this period 
on the patients who needed long term ventilatory supports. Out of which 52 
were male patients and 12 were females. Age of the patients were between 22 
and 70 years. After the procedure weaning time from the ventilator was 
noted. Most of the procedures were performed by percutaneous technique. 
RESULTS. The common diagnosis of the patients were brain injuries extradural 
and subdural hemorrhages 65 %, stroke 25 %, spinal injuries and other 
diagnosis 10 %.We performed tracheostomy within 7 days of the start of 
ventilation in most of the patients. After tracheostomy most of the patients 
(56 %) were able to be weaned off from the ventilatory support within next 2 
days and subsequently were shifted out of the intensive care unit to wards. 
The patients who expired in the intensive care unit were around 24 % and 
patients who were shifted to other centers for further management were 
around 20 %. Most frequent complications of the procedures were bleeding and 
endotracheal tube cuff perforation. CONCLUSIONS. The early performing of 
tracheostomy (within 5 days) resulted in decrease in peak air way pressure 
of the ventilator, decrease in requirement of the sedatives to the patients, 
helping in early weaning from the ventilator, increasing effectiveness of 
chest physiotherapy in removing the retained secretions. Here in our 
institute we have been performing the early tracheostomy in the patients who 
need long term ventilatory support or who we find difficult to wean from 
ventilator early.
EMTREE DRUG INDEX TERMS
  sedative agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hospital; India; intensive care; intensive care unit; society; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; bleeding; bodily secretions; brain injury; breathing exercise; cerebrovascular accident; diagnosis; endotracheal tube cuff; female; human; male; patient; perforation; procedures; spine injury; subdural hematoma; ventilator; ward; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71013805
DOI
  10.1007/s00134-012-2683-0
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-012-2683-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-012-2683-0&atitle=Benefits+of+performing+early+tracheostomy+in+the+intensive+care+unit+of+a+secondary+level+hospital+of+north+india%2C+our+two+years+experiences&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=38&issue=&spage=S162&epage=&aulast=Dhanda&aufirst=D.&auinit=D.&aufull=Dhanda+D.&coden=&isbn=&pages=S162-&date=2012&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 580
TITLE
  Cervicothoracic spinal cord and pontomedullary injury secondary to 
high-voltage electrocution: A case report
AUTHOR NAMES
  Johl H.K.; Olshansky A.; Beydoun S.R.; Rison R.A.
AUTHOR ADDRESSES
  (Johl H.K., harpreetjohl@gmail.com; Olshansky A., adel.olshansky@gmail.com) 
University of Southern California, Keck School of Medicine, Los Angeles 
County Medical Center, 1510 San Pablo Street, Los Angeles, CA 90033, United 
States.
(Beydoun S.R., sbeydoun@usc.edu) University of Southern California, Keck 
School of Medicine, LosAngeles County Medical Center, 1520 San Pablo Street, 
Los Angeles, CA 90033, United States.
(Rison R.A., rison@usc.edu) Presbyterian Intercommunity Hospital, 12401 
Washington Boulevard, Whittier, CA 90602, United States.
CORRESPONDENCE ADDRESS
  R.A. Rison, Presbyterian Intercommunity Hospital, 12401 Washington 
Boulevard, Whittier, CA 90602, United States. Email: rison@usc.edu
AiP/IP ENTRY DATE
  2012-09-18
FULL RECORD ENTRY DATE
  2012-10-02
SOURCE
  Journal of Medical Case Reports (2012) 6 Article Number: 296. Date of 
Publication: 2012
VOLUME
  6
DATE OF PUBLICATION
  2012
ISSN
  1752-1947 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., Floor 6, 236 Gray's Inn Road, London, United Kingdom.
ABSTRACT
  Introduction: High-voltage electrical injuries are uncommonly reported and 
may predispose to both immediate and delayed neurologic complications. Case 
presentation: We report the case of a 43-year-old Caucasian man who 
experienced a high-voltage electrocution injury resulting in ischemic 
myelopathy and secondary paraparesis. Conclusion: High-voltage electrocution 
injuries are a serious problem with potential for both immediate and delayed 
neurologic sequelae. The existing literature regarding effective treatment 
of neurologic complications is limited. Long-term follow-up and 
multidisciplinary management of these patients is required. © 2012 Johl et 
al.; licensee BioMed Central Ltd.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury (complication, diagnosis); electric burn (therapy); medulla oblongata; spinal cord injury (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; article; brain infarction (diagnosis); clinical article; electrolyte intake; flaccid paralysis (diagnosis); fluid resuscitation; gastrostomy; human; male; neurologic examination; nuclear magnetic resonance imaging; nutritional support; paraplegia (complication); priority journal; tracheostomy; wound care; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Radiology (14)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012553120
PUI
  L52212718
DOI
  10.1186/1752-1947-6-296
FULL TEXT LINK
  http://dx.doi.org/10.1186/1752-1947-6-296
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17521947&id=doi:10.1186%2F1752-1947-6-296&atitle=Cervicothoracic+spinal+cord+and+pontomedullary+injury+secondary+to+high-voltage+electrocution%3A+A+case+report&stitle=J.+Med.+Case+Rep.&title=Journal+of+Medical+Case+Reports&volume=6&issue=&spage=&epage=&aulast=Johl&aufirst=Harpreet+K.&auinit=H.K.&aufull=Johl+H.K.&coden=&isbn=&pages=-&date=2012&auinit1=H&auinitm=K
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 581
TITLE
  Expulsion of a screw by cough subsequent to anterior cervical spinal fusion: 
A case report
AUTHOR NAMES
  Shamim F.; Formal C.S.; Shamim R.S.
AUTHOR ADDRESSES
  (Formal C.S.; Shamim R.S.)
(Shamim F.) Thomas Jefferson University Hospital, Philadelphia, United 
States.
CORRESPONDENCE ADDRESS
  F. Shamim, Thomas Jefferson University Hospital, Philadelphia, United 
States.
FULL RECORD ENTRY DATE
  2012-11-06
SOURCE
  PM and R (2012) 4:10 SUPPL. 1 (S355-S356). Date of Publication: October 2012
VOLUME
  4
ISSUE
  10
FIRST PAGE
  S355
LAST PAGE
  S356
DATE OF PUBLICATION
  October 2012
CONFERENCE NAME
  2012 American Academy of Physical Medicine and Rehabilitation, AAPM&R Annual 
Assembly
CONFERENCE LOCATION
  Atlanta, GA, United States
CONFERENCE DATE
  2012-11-15 to 2012-11-18
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Case Description: A 37-year-old man presented to the emergency department 
reporting that he “coughed up a screw.” He had noticed difficulty swallowing 
and coughing while eating. History included anterior cervical discectomy and 
fusion (ACDF) 11 years prior. A radiograph of the cervical spine 
demonstrated C3-C7 instrumentation held in place by 3 screws, in contrast to 
a chest radiograph for dysphagia evaluation 4 months prior demonstrating 3 
intact screws and 1 loose screw. We believe that the loose screw penetrated 
the esophagus and trachea, producing esophageal perforation with dysphagia, 
tracheo-esophageal (T-E) fistula formation, and aspiration. The screw was 
then expelled by the patient via a cough mechanism. Program Description: 
ACDF can cause acute complications including dysphagia, esophageal 
perforation, and worsening of preexisting myelopathy. Late complications 
include screw loosen-ing and development of a fistulous tract into the 
esophagus with esophageal perforation by a loose screw. T-E fistula 
formation is not a described complication of ACDF. Setting: Tertiary care 
hospital. Results or Clinical Course: Direct laryngoscopy and esophagoscopy 
demonstrated a T-E fistula and posterior esophageal perforation. The patient 
received a tracheostomy for airway protection, as well as a 
gastrostomy-jejunostomy (G-J) tube to minimize the risk of aspiration. The 
patient was placed on clindamycin for prevention of aspiration pneumonia. 
Two months after presentation, the patient underwent a T-E fistula repair 
without complication. After the T-E fistula was healed and closed, the spine 
hardware was removed. Discussion: While there have been numerous case 
reports describing esophageal perforation of screws that have migrated away 
from an anterior cervical plate and passed through the GI tract without 
morbidity, there is no literature documenting T-E fistula formation and 
expulsion of a screw by cough. Conclusions: This complication was associated 
with significant morbidity and caused this patient to undergo 3 secondary 
surgeries. Hardware complications should be considered in the differential 
diagnosis for evaluating dysphagia and aspiration in patients with a history 
of anterior cervical fusion. Recognition and treatment of dysphagia due to 
hardware dysfunction 4 months prior may have prevented T-E fistula formation 
and 3 secondary surgeries.
EMTREE DRUG INDEX TERMS
  clindamycin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; coughing; human; physical medicine; rehabilitation; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  airway; aspiration; aspiration pneumonia; cervical spine; computer; devices; differential diagnosis; discectomy; disease course; dysphagia; eating; emergency ward; esophagoscopy; esophagus; esophagus perforation; fistula; gastrostomy; hospital; jejunostomy; laryngoscopy; male; morbidity; patient; prevention; protection; risk; spinal cord disease; spine; surgery; swallowing; tertiary health care; thorax radiography; trachea; tracheostomy; tube; X ray film; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70910226
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Expulsion+of+a+screw+by+cough+subsequent+to+anterior+cervical+spinal+fusion%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=4&issue=10&spage=S355&epage=S356&aulast=Formal&aufirst=Christopher+S.&auinit=C.S.&aufull=Formal+C.S.&coden=&isbn=&pages=S355-S356&date=2012&auinit1=C&auinitm=S
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 582
TITLE
  Post-critical care rehabilitation units: An essential link after intensive 
care units?
ORIGINAL (NON-ENGLISH) TITLE
  Service de rééducation post-réanimation (SRPR): un maillon indispensable 
après la réanimation?
AUTHOR NAMES
  Luauté J.; Tell L.
AUTHOR ADDRESSES
  (Luauté J., jacques.luaute@chu-lyon.fr; Tell L.) PAM de Rééducation des 
Hospices Civils de Lyon, Hôpital Henry-Gabrielle, 20, route de Vourles, 
Saint-Genis-Laval, France.
CORRESPONDENCE ADDRESS
  J. Luauté, PAM de Rééducation des Hospices Civils de Lyon, Hôpital 
Henry-Gabrielle, 20, route de Vourles, Saint-Genis-Laval, France. Email: 
jacques.luaute@chu-lyon.fr
FULL RECORD ENTRY DATE
  2012-12-20
SOURCE
  Annals of Physical and Rehabilitation Medicine (2012) 55 SUPPL.1 
(e355+e357-e358). Date of Publication: October 2012
VOLUME
  55
FIRST PAGE
  e355+e357
LAST PAGE
  e358
DATE OF PUBLICATION
  October 2012
CONFERENCE NAME
  27e Congres de Medecine Physique et de Readaptation
CONFERENCE LOCATION
  Toulouse, France
CONFERENCE DATE
  2012-10-18 to 2012-10-20
ISSN
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS
ABSTRACT
  The concept of post-critical care rehabilitation units emerged in France at 
the end of the twentieth century when progress in acute neurological care 
allowed brain or spinal injured patients to survive, but with severe 
impairments. Brain injured patients who have suffered a coma, and patients 
with tetraplegia, require important medical supervision with a dedicated 
program of rehabilitation and are the most likely to benefit from this type 
of environment. As opposed to critical care, patients should not be in a 
life-threatening condition. They may have a tracheotomy and/or a gastrostomy 
but fractures should have been treated before admission. A specific 
organisational structure is necessary in regard to the number of caregivers 
and rehabilitation professionals in order to manage medical events still 
frequent at this stage (e.g., agitation, neurovegetative crisis, 
complications of immobility), technical cares (e.g., tracheotomy, 
gastrostomy, intermittent bladder irrigation) and high dependency. Besides 
minimising the consequences of immobility, especially respiratory 
complications, the functional assessment and rehabilitation of impairments 
are central at this point as these are often not investigated sufficiently 
in intensive care units. Evaluation of awareness may be a specific goal for 
patients with chronic conscious disorders before the orientation toward 
units dedicated for vegetative and minimally conscious states. An increased 
number of post-acute rehabilitation units have been created in recent years 
but the status and the funding of this type of organisation is still not 
clear within the French care system.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adaptation; intensive care; intensive care unit; rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  agitation; bladder irrigation; brain; caregiver; coma; diseases; environment; fracture; France; functional assessment; funding; gastrostomy; human; immobilization; minimally conscious state; patient; quadriplegia; tracheotomy; 
LANGUAGE OF ARTICLE
  French, English
LANGUAGE OF SUMMARY
  English, French
PUI
  L70941549
DOI
  10.1016/j.rehab.2012.07.905
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2012.07.905
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770657&id=doi:10.1016%2Fj.rehab.2012.07.905&atitle=Post-critical+care+rehabilitation+units%3A+An+essential+link+after+intensive+care+units%3F&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=55&issue=&spage=e355%2Be357&epage=e358&aulast=Luaut%C3%A9&aufirst=J.&auinit=J.&aufull=Luaut%C3%A9+J.&coden=&isbn=&pages=e355%2Be357-e358&date=2012&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 583
TITLE
  Postoperative emergence in patients undergoing cardiac surgery with 
cardiopulmonary bypass-a retrospective study
AUTHOR NAMES
  Uehara K.
AUTHOR ADDRESSES
  (Uehara K.) Departments of Anesthesia and Intensive Care, Hiroshima City 
Hospital, Hiroshima, Japan.
CORRESPONDENCE ADDRESS
  K. Uehara, Departments of Anesthesia and Intensive Care, Hiroshima City 
Hospital, Hiroshima, Japan.
FULL RECORD ENTRY DATE
  2013-08-16
SOURCE
  Journal of Neurosurgical Anesthesiology (2012) 24:4 (514). Date of 
Publication: October 2012
VOLUME
  24
ISSUE
  4
FIRST PAGE
  514
DATE OF PUBLICATION
  October 2012
CONFERENCE NAME
  16th Annual Meeting of the Japanese Society of Neuroanesthesia and Critical 
Care
CONFERENCE LOCATION
  Okayama, Japan
CONFERENCE DATE
  2012-04-13 to 2012-04-14
ISSN
  0898-4921
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Neurologic deficits after cardiac surgery with cardiopulmonary 
bypass (CPB) are serious complications. Accelerated recovery is recommended 
for detecting neurologic complications. Remifentanil has become one of the 
most widely used anesthetic agents for early emergence, but there is limited 
information about recovery. In this study, clinical recovery of patients 
undergoing cardiac surgery was evaluated. Methods: We consecutively 
conducted a retrospective analysis of adult patients who underwent cardiac 
surgery with CPB at the Hiroshima City Hospital between January and June 
2011. Seven patients who underwent descending thoracic aortic graft 
replacement were excluded because of the risk of spinal cord ischemia. 
Emergence was defined as nodding the head or making a grip in response to a 
verbal command. Results: There were 42 males and 25 females with a mean age 
of 67.2 years (SD, 13.8 y). Anesthesia was maintained with 
sevoflurane-remifentanil (pre-CPB) or propofol-remifentanil (during and 
post-CPB) except for 1 case. The mean operation time was 373 minutes (SD, 
134 min). Eighteen patients who received propofol sedation recovered on 
postoperative day (POD) 0 or 1. Propofol was discontinued in 49 patients on 
POD 0 (n=15), POD 1 (n=32), POD 2 (n=1), or POD 3 (n=1). The mean time to 
emergence from propofol was 138 minutes (132 min). Neurologic complications 
were detected in 3 (4.5%) of the 67 patients. The first patient presented 
with anisocoria and the second patient presented with right upper extremity 
paralysis after recovery of consciousness. Computed tomography (CT) revealed 
ischemic stroke in both cases. The third patient recovered on POD 1. 
However, she did not fully recover after resedation followed by tracheotomy. 
CT showed no new lesion. Conclusions: Sixty-seven patients undergoing 
cardiac surgery with CPB emerged from remifentanil-based anesthesia on POD 0 
(n=14), POD 1 (n=49), POD 2 (n=3), or POD 3 (n=1). The mean time to recovery 
of consciousness after propofol sedation was 138 minutes. The incidence of 
neurologic complications was 4.5% (n=3). CT revealed ischemic stroke in 2 
patients and no finding in 1 patient.
EMTREE DRUG INDEX TERMS
  anesthetic agent; nitrogen 15; propofol; remifentanil; sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; cardiopulmonary bypass; heart surgery; human; intensive care; Japanese (people); patient; retrospective study; society; 
EMTREE MEDICAL INDEX TERMS
  adult; anisocoria; aortic graft; arm; brain ischemia; city; computer assisted tomography; consciousness; female; hospital; male; neurological complication; operation duration; paralysis; risk; sedation; spinal cord ischemia; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71131885
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08984921&id=doi:&atitle=Postoperative+emergence+in+patients+undergoing+cardiac+surgery+with+cardiopulmonary+bypass-a+retrospective+study&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=24&issue=4&spage=514&epage=&aulast=Uehara&aufirst=Kenji&auinit=K.&aufull=Uehara+K.&coden=&isbn=&pages=514-&date=2012&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 584
TITLE
  Open repair of chronic distal aortic dissection in the endovascular era: 
Implications for disease management
AUTHOR NAMES
  Pujara A.C.; Roselli E.E.; Hernandez A.V.; Vargas Abello L.M.; Burke J.M.; Svensson L.G.; Greenberg R.K.
AUTHOR ADDRESSES
  (Pujara A.C.; Roselli E.E., roselle@ccf.org; Vargas Abello L.M.; Burke J.M.; 
Svensson L.G.; Greenberg R.K.) Department of Thoracic and Cardiovascular 
Surgery, Cleveland Clinic, 9500 Euclid Avenue, Desk J4-1, Cleveland, OH 
44195, United States.
(Pujara A.C.; Roselli E.E., roselle@ccf.org; Hernandez A.V.) Cleveland 
Clinic Lerner College of Medicine, Case Western Reserve University, 
Cleveland Clinic, Cleveland, OH, United States.
(Hernandez A.V.) Department of Quantitative Health Sciences, Cleveland 
Clinic, Cleveland, OH, United States.
(Vargas Abello L.M.; Greenberg R.K.) Department of Vascular Surgery, 
Cleveland Clinic, Cleveland, OH, United States.
CORRESPONDENCE ADDRESS
  E.E. Roselli, Department of Thoracic and Cardiovascular Surgery, Cleveland 
Clinic, 9500 Euclid Avenue, Desk J4-1, Cleveland, OH 44195, United States. 
Email: roselle@ccf.org
AiP/IP ENTRY DATE
  2012-02-27
FULL RECORD ENTRY DATE
  2012-10-01
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2012) 144:4 (866-873). Date 
of Publication: October 2012
VOLUME
  144
ISSUE
  4
FIRST PAGE
  866
LAST PAGE
  873
DATE OF PUBLICATION
  October 2012
ISSN
  0022-5223
  1097-685X (electronic)
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  Objective: Controversy surrounds the treatment of chronic aortic dissection. 
Open surgical and endovascular experiences include mixed populations treated 
with evolving strategies and limited follow-up. We establish a standard 
against which endovascular repair can be compared by assessing outcomes 
after open repair of chronic distal aortic dissections anatomically suitable 
to stent-grafting. Methods: From 2000 to 2008, 169 patients underwent open 
repair of the descending thoracic artery only (n = 88) or thoracoabdominal 
(n = 81) chronic aortic dissection (elective in 98, urgent/emergency in 71). 
Chart review and 3-dimensional assessment of computed tomography were 
performed. Poor outcome included all-cause mortality or vascular 
reintervention. Results: Thirty-day mortality was 8% (n = 14). Serious 
complications included neurologic (n = 12 [spinal cord n = 4, 2.4%]), 
respiratory (n = 32), and renal failure (n = 1 descending thoracic artery 
only vs 17 thoracoabdominal, P < .001). Chronic obstructive pulmonary 
disease predicted early mortality (hazard ratio 8.0, P = .005). Survival at 
1, 2, and 5 years was 76%, 69%, and 55%, respectively; 23 patients (14%) 
required reintervention. Event-free survival at 5 years was 51% and 47% 
after descending thoracic artery only or thoracoabdominal repair, 
respectively. Greater maximum aortic diameter (hazard ratio 1.9, P = .03) 
and greater diameter at the diaphragm (hazard ratio 3.7, P = .01) or renal 
segment (hazard ratio 4.3, P = .03) predicted poor outcome. Conclusions: 
Early outcomes are good and late outcomes are less than desirable after open 
repair of chronic distal aortic dissection, regardless of the extent of 
repair. High-risk and late-stage patients with larger and more extensive 
aneurysmal degeneration warrant further investigation, including the use of 
newer, less-invasive techniques. Select patients at risk for aneurysmal 
degeneration should undergo a more aggressive initial approach with aortic 
dissection repair.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); thoracic aortic surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; artery diameter; article; chronic obstructive lung disease; computer assisted tomography; diaphragm; endovascular surgery; event free survival; female; follow up; human; kidney disease (complication); kidney failure (complication, therapy); length of stay; major clinical study; male; medical record review; neurological complication (complication); paralysis (complication); paraplegia (complication); priority journal; respiratory failure (complication, therapy); respiratory tract disease (complication); retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012550905
MEDLINE PMID
  22341656 (http://www.ncbi.nlm.nih.gov/pubmed/22341656)
PUI
  L51869532
DOI
  10.1016/j.jtcvs.2012.01.021
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2012.01.021
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225223&id=doi:10.1016%2Fj.jtcvs.2012.01.021&atitle=Open+repair+of+chronic+distal+aortic+dissection+in+the+endovascular+era%3A+Implications+for+disease+management&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=144&issue=4&spage=866&epage=873&aulast=Pujara&aufirst=Akshat+C.&auinit=A.C.&aufull=Pujara+A.C.&coden=JTCSA&isbn=&pages=866-873&date=2012&auinit1=A&auinitm=C
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 585
TITLE
  Evaluation of the activity in the rehabilitation and post-intensive care 
departments in the Toulouse university hospital
ORIGINAL (NON-ENGLISH) TITLE
  Évaluation de l'activité de rééducation post-réanimation au sein du CHU de 
Toulouse
AUTHOR NAMES
  Montaut C.; Terracol C.; De Boissezon X.; Marque P.; Labrunee M.; Castel-Lacanal E.
AUTHOR ADDRESSES
  (Montaut C., cakey@hotmail.fr; Terracol C.; De Boissezon X.; Marque P.; 
Labrunee M.; Castel-Lacanal E.) Service de MPR, CHU Toulouse-Rangueil, 1, 
avenue Jean-Poulhès, Toulouse, France.
CORRESPONDENCE ADDRESS
  C. Montaut, Service de MPR, CHU Toulouse-Rangueil, 1, avenue Jean-Poulhès, 
Toulouse, France. Email: cakey@hotmail.fr
FULL RECORD ENTRY DATE
  2012-12-20
SOURCE
  Annals of Physical and Rehabilitation Medicine (2012) 55 SUPPL.1 
(e355+e358). Date of Publication: October 2012
VOLUME
  55
FIRST PAGE
  e355+e358
DATE OF PUBLICATION
  October 2012
CONFERENCE NAME
  27e Congres de Medecine Physique et de Readaptation
CONFERENCE LOCATION
  Toulouse, France
CONFERENCE DATE
  2012-10-18 to 2012-10-20
ISSN
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS
ABSTRACT
  Introduction and objectives.- In the Service of Physical Medicine and 
Rehabilitation Toulouse University Hospital, 6-bed rehabilitation 
postreanimation (RPR) were opened in August 2008. After more than three 
years, we review this new activity. Method.-We analyzed the epidemiological 
data (age, sex), the original service, the primary pathology, duration of 
stay and mode of exit. Results.- Hundred and eight patients (73 men 68% and 
35 women 32%) aged 49.6 ± 16.4 years stayed in our unit RPR, for an average 
of 64.5 ± 66 days. The reason for these hospitalizations was the 
consequences of a “reanimation” in 37 patients (34%), 22 (20%) were 
tracheostomized and four (4%) under controlled ventilation, nine were in the 
process of awakening (8%) and nine (8%) with behavioral disorders that 
require monitoring. The original service was neurology for 25 patients 
(23%), neurosurgery in 24 patients (22%), the unit of organ transplantation 
in 10 patients (9%) and the intensive care unit for nine patients (8%). The 
main pathology was stroke in 28 patients (26%), spinal cord injury in 19 
patients (18%), multiple sclerosis in nine patients (8%) and transplantation 
in eight patients (7%). Forty-three patients (40%) went in our area of 
traditional hospitalization, 15 (14%) went to another department follow-up 
care and 26 (24%) returned home, including four hospitalization at home. One 
died in the service Conclusion.- This activity rehabilitation 
post-reanimation corresponds to a real need for public health, and patients 
may benefit from specific rehabilitation associated with appropriate and 
specialized medical care. The duration of stay is long and we must improve 
our collaboration with other post-acute unit, in particular the early 
learning centers.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adaptation; epidemiology; intensive care unit; rehabilitation; university hospital; 
EMTREE MEDICAL INDEX TERMS
  arousal; artificial ventilation; behavior disorder; cerebrovascular accident; epidemiological data; female; follow up; hospitalization; human; learning; male; medical care; monitoring; multiple sclerosis; neurology; neurosurgery; organ transplantation; pathology; patient; physical medicine; public health; resuscitation; spinal cord injury; transplantation; 
LANGUAGE OF ARTICLE
  French, English
LANGUAGE OF SUMMARY
  English, French
PUI
  L70941550
DOI
  10.1016/j.rehab.2012.07.906
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2012.07.906
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770657&id=doi:10.1016%2Fj.rehab.2012.07.906&atitle=Evaluation+of+the+activity+in+the+rehabilitation+and+post-intensive+care+departments+in+the+Toulouse+university+hospital&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=55&issue=&spage=e355%2Be358&epage=&aulast=Montaut&aufirst=C.&auinit=C.&aufull=Montaut+C.&coden=&isbn=&pages=e355%2Be358-&date=2012&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 586
TITLE
  Neck Neoplastic Conditions in the Emergency Setting: Role of Multidetector 
Computed Tomography
AUTHOR NAMES
  Caranci F.; Brunese L.; Reginelli A.; Napoli M.; Fonio P.; Briganti F.
AUTHOR ADDRESSES
  (Caranci F., ferdinandocaranci@libero.it; Napoli M.; Briganti F.) Department 
of Diagnostic Radiology and Radiotherapy, Federico II University of Naples, 
Naples, Italy.
(Brunese L.) Department of Health Science, Chair of Radiology, University of 
Molise, Campobasso, Italy.
(Reginelli A.) Institute of Radiology, Second University of Naples, Naples, 
Italy.
(Fonio P.) Institute of Radiology, University of Turin, Turin, Italy.
CORRESPONDENCE ADDRESS
  F. Caranci, Department of Diagnostic Radiology and Radiotherapy, Federico II 
University of Naples, Via Boccaccio 2, 80123 Naples, Italy. Email: 
ferdinandocaranci@libero.it
AiP/IP ENTRY DATE
  2012-09-18
FULL RECORD ENTRY DATE
  2012-09-21
SOURCE
  Seminars in Ultrasound, CT and MRI (2012) 33:5 (443-448). Date of 
Publication: October 2012
VOLUME
  33
ISSUE
  5
FIRST PAGE
  443
LAST PAGE
  448
DATE OF PUBLICATION
  October 2012
ISSN
  0887-2171
  1558-5034 (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Emergent conditions resulting from head and neck neoplasms and their 
treatment include acute airway obstruction, hemorrhage, spinal cord 
compression, bilateral vocal cord paralysis, and septic thrombophlebitis. 
These conditions require accurate diagnosis and rapid intervention to avoid 
severe permanent damage or death. Successful treatment requires a 
coordinated response by emergency medicine physicians, otolaryngologists, 
vascular surgeons, and radiologists. We review these head and neck 
oncological conditions, whichpresent emergently, with a focus on 
radiological evaluation and interpretation.© 2012 Elsevier Inc.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); dexamethasone (drug therapy); steroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency medicine; head and neck tumor (diagnosis); multidetector computed tomography; 
EMTREE MEDICAL INDEX TERMS
  acute airway obstruction (diagnosis, surgery); acute neck soft tissue hemorrhage (diagnosis); airway obstruction (diagnosis); anaplastic carcinoma (diagnosis, radiotherapy); article; cancer radiotherapy; conventional angiography; diagnostic value; drug megadose; dyspnea; head and neck disease (diagnosis); head and neck squamous cell carcinoma (diagnosis); hemoptysis (diagnosis, radiotherapy, surgery); human; laryngoscopy; larynx disorder (diagnosis, drug therapy, radiotherapy, surgery); nuclear magnetic resonance imaging; perfusion weighted imaging; predictive value; priority journal; respiratory distress; septic thrombophlebitis (diagnosis, drug therapy, therapy); septic thrombophlebitis (drug therapy); spinal cord compression (diagnosis, drug therapy); stridor; supralaryngeal obstruction (drug therapy); supralaryngeal obstruction (diagnosis, drug therapy, radiotherapy, surgery); thrombophlebitis (diagnosis, drug therapy, therapy); tracheostomy; vocal cord paralysis (diagnosis); 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Cancer (16)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012532483
MEDLINE PMID
  22964410 (http://www.ncbi.nlm.nih.gov/pubmed/22964410)
PUI
  L365609301
DOI
  10.1053/j.sult.2012.06.011
FULL TEXT LINK
  http://dx.doi.org/10.1053/j.sult.2012.06.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08872171&id=doi:10.1053%2Fj.sult.2012.06.011&atitle=Neck+Neoplastic+Conditions+in+the+Emergency+Setting%3A+Role+of+Multidetector+Computed+Tomography&stitle=Semin.+Ultrasound+CT+MRI&title=Seminars+in+Ultrasound%2C+CT+and+MRI&volume=33&issue=5&spage=443&epage=448&aulast=Caranci&aufirst=Ferdinando&auinit=F.&aufull=Caranci+F.&coden=SUCME&isbn=&pages=443-448&date=2012&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 587
TITLE
  The prevalence of malnutrition in spinal cord injuries patients: A UK 
multicentre study
AUTHOR NAMES
  Wong S.; Derry F.; Jamous A.; Hirani S.P.; Grimble G.; Forbes A.
AUTHOR ADDRESSES
  (Wong S., samford.wong@ucl.ac.uk; Derry F.; Jamous A.) Department of 
Nutrition and Dietetics, National Spinal Injuries Centre, Stoke Mandeville 
Hospital, Aylesbury HP21 8AL, United Kingdom.
(Wong S., samford.wong@ucl.ac.uk; Grimble G.; Forbes A.) Centre for 
Gastroenterology and Clinical Nutrition, University College London, London, 
WC1E 6BT, United Kingdom.
(Hirani S.P.) School of Community and Health Science, City University, 
London, EC1 0HB, United Kingdom.
CORRESPONDENCE ADDRESS
  S. Wong, Department of Nutrition and Dietetics, National Spinal Injuries 
Centre, Stoke Mandeville Hospital, Aylesbury HP21 8AL, United Kingdom. 
Email: samford.wong@ucl.ac.uk
AiP/IP ENTRY DATE
  2013-08-23
FULL RECORD ENTRY DATE
  2013-09-04
SOURCE
  British Journal of Nutrition (2012) 108:5 (918-923). Date of Publication: 
September 14, 2012
VOLUME
  108
ISSUE
  5
FIRST PAGE
  918
LAST PAGE
  923
DATE OF PUBLICATION
  September 14, 2012
ISSN
  0007-1145
  1475-2662 (electronic)
BOOK PUBLISHER
  Cambridge University Press, Shaftesbury Road, Cambridge, United Kingdom.
ABSTRACT
  Data on the prevalence of malnutrition among patients with spinal cord 
injuries (SCI) are lacking. The aim of the present study was to assess 
nutritional risk at admission, and the status of nutritional support in the 
UK SCI Centres (SCIC); a cross-sectional, multicentre study in four SCIC. A 
standardised questionnaire was used and distributed to the participating 
SCIC. After obtaining informed consent, baseline demographic data, 
nutritional risk score by the 'Malnutrition Universal Screening Tool', BMI 
and routine blood biochemistry were collected from every patient admitted to 
an SCIC. The four SCIC, comprising 48·2 % of the total UK SCI beds, 
contributed data from 150 patients. On admission, 44·3 % of patients were 
malnourished or at risk of undernutrition. Nutritional risk was more common 
in patients with acute high cervical SCI than those with lower SCI (60·7 v. 
34·5 %), and nutritional risk was more common in those with additional 
complications including ventilatory support (with tracheostomy, 56·3 v. 38·7 
%). Also, 45 % of patients were at risk of overnutrition (BMI ≥ 25 kg/m 
(2)). The prevalence of malnutrition in SCI patients admitted to SCIC is 
higher than national figures focused on general hospitalised patients, 
indicating that SCI patients are particularly vulnerable to malnutrition. 
Patients with SCI who have a tracheostomy may need additional attention. 
Given the potential negative impact of malnutrition on clinical outcomes, an 
emphasis on mandatory nutrition screening, followed by detailed assessment 
for at-risk individuals should be in place in the SCIC. © 2011 The Authors.
EMTREE DRUG INDEX TERMS
  albumin (endogenous compound); creatinine (endogenous compound); hemoglobin (endogenous compound); magnesium (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  malnutrition (epidemiology); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; age distribution; aged; albumin blood level; article; artificial ventilation; body mass; cervical spinal cord injury; controlled study; creatinine blood level; cross-sectional study; decreased appetite; disease association; disease predisposition; female; hemoglobin blood level; high risk patient; human; length of stay; magnesium blood level; major clinical study; male; nutritional assessment; nutritional status; nutritional support; overnutrition (epidemiology); prevalence; risk assessment; tracheostomy; vulnerable population; 
CAS REGISTRY NUMBERS
  creatinine (19230-81-0, 60-27-5)
  hemoglobin (9008-02-0)
  magnesium (7439-95-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2013513290
MEDLINE PMID
  22172226 (http://www.ncbi.nlm.nih.gov/pubmed/22172226)
PUI
  L369573319
DOI
  10.1017/S0007114511006234
FULL TEXT LINK
  http://dx.doi.org/10.1017/S0007114511006234
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00071145&id=doi:10.1017%2FS0007114511006234&atitle=The+prevalence+of+malnutrition+in+spinal+cord+injuries+patients%3A+A+UK+multicentre+study&stitle=Br.+J.+Nutr.&title=British+Journal+of+Nutrition&volume=108&issue=5&spage=918&epage=923&aulast=Wong&aufirst=Samford&auinit=S.&aufull=Wong+S.&coden=BJNUA&isbn=&pages=918-923&date=2012&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 588
TITLE
  Percutaneous tracheostomy in patients with cervical spine immobilization
AUTHOR NAMES
  Haque A.; Rajajee V.; Fletcher J.
AUTHOR ADDRESSES
  (Haque A.; Rajajee V.; Fletcher J.) Department of Neurology, University of 
Michigan, Ann Arbor, United States.
(Rajajee V.; Fletcher J.) Department of Neurosurgery, University of 
Michigan, Ann Arbor, United States.
CORRESPONDENCE ADDRESS
  A. Haque, Department of Neurology, University of Michigan, Ann Arbor, United 
States.
FULL RECORD ENTRY DATE
  2012-11-29
SOURCE
  Neurocritical Care (2012) 17 SUPPL. 2 (S82). Date of Publication: September 
2012
VOLUME
  17
FIRST PAGE
  S82
DATE OF PUBLICATION
  September 2012
CONFERENCE NAME
  10th Annual Meeting of the Neurocritical Care Society
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2012-10-04 to 2012-10-07
ISSN
  1541-6933
BOOK PUBLISHER
  Humana Press
ABSTRACT
  Introduction: Cervical Spine Immobilization (CSI) is a relative 
contraindication for percutaneous dilatational tracheostomy (PDT) because of 
the inability to extend the neck, making tracheal puncture at the correct 
level more challenging. Patients with CSI routinely undergo PDT at our 
institution, however, with both traditional bronchoscopic as well as with 
real-time ultrasound (RTU) guidance. Our objective was to review the 
incidence of complications related to PDT in patients with CSI versus 
patients without CSI. Methods: We reviewed the records of consecutive 
patients who underwent PDT performed by a single operator at our 
neurocritical care unit between 6/2008-5/2012. All patients requiring 
tracheostomy are screened for eligibility for PDT by the attending 
neurointensivist on service. We recorded the percentage of patients who 
successfully underwent PDT vs requiring conversion to surgical tracheostomy, 
the specific guidance used (bronchoscopy, RTU) and all short- and long-term 
complications including placement of the tube above the first tracheal ring. 
Results: A total of 112 patients underwent PDT performed by a single 
neurointensivist. All patients screened by the operator underwent an attempt 
at PDT, and all patients successfully completed the procedure without 
conversion to surgical tracheostomy. Ninety-eight of 112 (87%) did not 
require CSI and 14 (13%) required CSI. In the CSI group, bronchoscopy alone 
was used in 6/14 (43%) and bronchoscopy plus RTU in 8/14 (57%). No 
complications occurred in the CSI group. In the no-CSI group, there were 3 
(3%) complications (one tracheal granuloma and two tube dislodgments within 
7 days). No other short or long term complications were recorded. All tubes 
were placed below the first tracheal ring. Conclusions: It is feasible to 
safely perform PDT in patients with Cervical Spine Immobilization using 
bronchoscopic and real-time ultrasound guidance.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; human; immobilization; patient; society; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  bronchoscopy; granuloma; neck; procedures; puncture; real time echography; tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70930027
DOI
  10.1007/s12028-012-9775-0
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12028-012-9775-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15416933&id=doi:10.1007%2Fs12028-012-9775-0&atitle=Percutaneous+tracheostomy+in+patients+with+cervical+spine+immobilization&stitle=Neurocrit.+Care&title=Neurocritical+Care&volume=17&issue=&spage=S82&epage=&aulast=Haque&aufirst=Asim&auinit=A.&aufull=Haque+A.&coden=&isbn=&pages=S82-&date=2012&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 589
TITLE
  A single instituitional experience of 42 cases of pediatric cervical spine 
trauma from India : Are they different from adult cervical trauma
AUTHOR NAMES
  Gupta D.; Prasad G.L.; Dash C.; Mahapatra A.K.; Agrawal D.
AUTHOR ADDRESSES
  (Gupta D.; Prasad G.L.; Dash C.; Mahapatra A.K.; Agrawal D.) All India 
Institute of Medical Sciences, Delhi, India.
CORRESPONDENCE ADDRESS
  D. Gupta, All India Institute of Medical Sciences, Delhi, India.
FULL RECORD ENTRY DATE
  2012-10-01
SOURCE
  Child's Nervous System (2012) 28:9 (1615). Date of Publication: September 
2012
VOLUME
  28
ISSUE
  9
FIRST PAGE
  1615
DATE OF PUBLICATION
  September 2012
CONFERENCE NAME
  40th Annual Meeting of the International Society for Pediatric Neurosurgery
CONFERENCE LOCATION
  Sydney, NSW, Australia
CONFERENCE DATE
  2012-09-09 to 2012-09-13
ISSN
  0256-7040
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Introduction: Pediatric cervical spine injuries are relatively uncommon . 
Falls are themost common cause. Children have relatively high incidence of 
upper cervical injuries and their management includes conservative and 
surgical methods. Objectives: This study was carried out to analyse the 
epidemiologic profile of pediatric cervical spine injuries and to evaluate 
the clinico-radiological characteristics of cervical spine injuries in 
children, to correlate the outcome with the clinico-radiological features. 
Methodology: Prospective cum retrospective data analysis ( 2008- 2011) at 
JPN apex trauma centre, New Delhi, India. 42 children (0-18 yrs) were 
operated during this period. Fall from height was noted in 27 cases, upper 
cervical spine injuries in 12/42 cases( odontoid fractures in 6 cases). 
Associated injuries were noted in 8 cases, preop ASIAAscore was noted in 16 
cases. Two cases had preop systemic hypotension and required ventilator 
support. Anterior only approach was used in 26 cases( 61 %). Postoperative 
VAP was noted in 28 % cases, 38 % required tracheostomy, 
perioperativemortality noted in 2 cases. Implant failure on long term follow 
up seen in 2 cases.. 13 of 16 children who came for follow up had become 
independent for ADL( 81 %) at a follow up range of 4-40 months. Conclusions: 
Ligamentous injuries are commoner in pediatric patients, fall from height 
most commonly noted in Indian population, subaxial trauma more common than 
upper cervical trauma. 81 % had good outcome at last follow up. Such 
observation warrants aggressive surgical approach in pediatric population to 
give them better neurological outcome.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult; cervical spine injury; India; neurosurgery; society; 
EMTREE MEDICAL INDEX TERMS
  child; data analysis; follow up; height; human; hypotension; implant; Indian; injury; methodology; odontoid process fracture; patient; population; surgical approach; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70879731
DOI
  10.1007/s00381-012-1849-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-012-1849-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-012-1849-y&atitle=A+single+instituitional+experience+of+42+cases+of+pediatric+cervical+spine+trauma+from+India+%3A+Are+they+different+from+adult+cervical+trauma&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=28&issue=9&spage=1615&epage=&aulast=Gupta&aufirst=Deepak&auinit=D.&aufull=Gupta+D.&coden=&isbn=&pages=1615-&date=2012&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 590
TITLE
  Dysphagia and associated respiratory considerations in cervical spinal cord 
injury
AUTHOR NAMES
  Chaw E.; Shem K.; Castillo K.; Wong S.; Chang J.
AUTHOR ADDRESSES
  (Chaw E.; Shem K.) Department of Physical Medicine and Rehabilitation, Santa 
Clara Valley Medical Center, San Jose, CA, United States.
(Castillo K.) Department of Therapy Services, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
(Wong S.) Department of Respiratory Care Services, Santa Clara Valley 
Medical Center, San Jose, CA, United States.
(Chang J.) Rehabilitation Research Center, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
CORRESPONDENCE ADDRESS
  E. Chaw, Department of Physical Medicine and Rehabilitation, Santa Clara 
Valley Medical Center, San Jose, CA, United States.
AiP/IP ENTRY DATE
  2012-10-03
FULL RECORD ENTRY DATE
  2012-10-12
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2012) 18:4 (291-299). Date of 
Publication: 1 Sep 2012
VOLUME
  18
ISSUE
  4
FIRST PAGE
  291
LAST PAGE
  299
DATE OF PUBLICATION
  1 Sep 2012
ISSN
  1082-0744
  1945-5763 (electronic)
BOOK PUBLISHER
  Thomas Land Publishers Inc., 255 Jefferson Road, St. Louis, United States.
ABSTRACT
  Background: Dysphagia is a relatively common secondary complication that 
occurs after acute cervical spinal cord injury (SCI). The detrimental 
consequences of dysphagia in SCI include transient hypoxemia, chemical 
pneumonitis, atelectasis, bronchospasm, and pneumonia. The expedient 
diagnosis of dysphagia is imperative to reduce the risk of the development 
of life-threatening complications. Objective: The objective of this study 
was to identify risk factors for dysphagia after SCI and associated 
respiratory considerations in acute cervical SCI. Methods: Bedside swallow 
evaluation (BSE) was conducted in 68 individuals with acute cervical SCI who 
were admitted to an SCI specialty unit. Videofluroscopy swallow study was 
conducted within 72 hours of BSE when possible. Results: This prospective 
study found dysphagia in 30.9% (21 out of 68) of individuals with acute 
cervical SCI. Tracheostomy (P =.028), ventilator use (P =.012), and 
nasogastric tube (P =.049) were found to be significant associated factors 
for dysphagia. Furthermore, individuals with dysphagia had statistically 
higher occurrences of pneumonia when compared with persons without dysphagia 
(P <.001). There was also a trend for individuals with dysphagia to have 
longer length of stay (P =.087). Conclusion: The role of respiratory care 
practitioners in the care of individuals with SCI who have dysphagia needs 
to be recognized. Aggressive respiratory care enables individuals with 
potential dysphagia to be evaluated by a speech pathologist in a timely 
manner. Early evaluation and intervention for dysphagia could decrease 
morbidity and improve overall clinical outcomes. © 2012 Thomas Land 
Publishers, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); dysphagia (complication, etiology, therapy); respiratory care; 
EMTREE MEDICAL INDEX TERMS
  abnormal respiratory sound; acute disease; adult; article; clinical evaluation; controlled study; disease association; female; human; length of stay; major clinical study; male; nasogastric tube; physician; pneumonia; postoperative complication; prospective study; risk factor; speech therapy; spine surgery; swallowing; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012566114
PUI
  L365709935
DOI
  10.1310/sci1804-291
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci1804-291
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci1804-291&atitle=Dysphagia+and+associated+respiratory+considerations+in+cervical+spinal+cord+injury&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=18&issue=4&spage=291&epage=299&aulast=Chaw&aufirst=Edward&auinit=E.&aufull=Chaw+E.&coden=TSIRF&isbn=&pages=291-299&date=2012&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 591
TITLE
  A retrospective review of the spinal fusion outcomes and complications for a 
pediatric cohort receiving long-term mechanical ventilation in the 
pre-operative period
AUTHOR NAMES
  Amin R.; Chowdhury F.; Zeller R.
AUTHOR ADDRESSES
  (Amin R.) Hospital for Sick Children, Toronto, Canada.
(Chowdhury F.) University of Toronto, Toronto, Canada.
(Zeller R.) Hospital of Sick Children, Toronto, Canada.
CORRESPONDENCE ADDRESS
  R. Amin, Hospital for Sick Children, Toronto, Canada.
FULL RECORD ENTRY DATE
  2015-09-08
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2012) 185 
MeetingAbstracts. Date of Publication: 2012
VOLUME
  185
DATE OF PUBLICATION
  2012
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2012
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2012-05-18 to 2012-05-23
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Rationale To determine the spinal fusion outcomes and complications of 
pediatric patients maintained on pre-operative long-term non-invasive 
positive pressure ventilation (NiPPV). Methods A retrospective chart review 
was conducted on patients receiving pre-operative long-term NiPPV who 
underwent spinal fusion surgery between January 2002 and June 2010, at 
SickKids hospital, Toronto. Neuromuscular patients not receiving 
pre-operative NiPPV matched for age, sex and Cobb angle (±20° up to 80° or 
≥80°) served as the controls. Outcome measures included Cobb angle, duration 
of stay in hospital and the intensive care unit, pulmonary and other 
complications, mortality rate and need for tracheostomy. Results Sixteen 
patients (6 male) receiving pre-operative long term NiPPV underwent spinal 
fusion during the study period; 32 patients (12 male) served as controls. 
The median age at surgery for the ventilated patients (VP) and control 
patients (CP) was 13 years (range 8-16) and 14 years (range 9-18), 
respectively. The median pre-operative Forced Vital Capacity (FVC) was 0.50L 
(range 0.29-1.82) and 1.57L (range 0.62-3.28), respectively for the VP and 
CP (p=0.001). Four of the VP but none of the CP had FVC less than 500ml 
preoperatively. The median preoperative Cobb angle was 81° (range 38-116) 
for the VP and 79° (range 31-120) for the CP. This changed to 34° (range 
23-71.7) and 39° (range 30-54) after spinal fusion. The improvement in Cobb 
angle was not different between groups. All the VP underwent posterior 
fusion. The surgical approach for the CP was posterior for 26 patients, 
anterior for 1 patient, staged for three and non-staged anterior release and 
posterior fusion for one. The median hospital stay for VP was 8.5 days 
(range 6-29) and 11.0 days (6-57) for CP (p=0.4). The median intensive care 
unit stay for the VP was 6.1 days (range 1-24) and 1.5 days (1-8) for the CP 
(p=0.01). Five of the CP required short term NiPPV post-operatively. The 
median supplemental oxygen usage for VP was 2.0 days (range 0-7) and 4.1 
days (range 0-27 ) for the CP (p=0.1). Twelve (75%) VP developed pulmonary 
complications as compared to 16 (50%) CP. Lower limb paralysis which 
resolved occurred in 1 VP. There were no mortalities or tracheostomy 
insertions in either group. Conclusions Patients with pre-operative long 
term NiPPV can be safely operated on for correction of their deformity. 
Therefore, the option of surgical correction should be offered to these 
patients to maximize function and quality of life despite the 
cardiorespiratory risks.
EMTREE DRUG INDEX TERMS
  oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; artificial ventilation; society; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  Cobb angle; deformity; forced vital capacity; hospital; hospitalization; human; intensive care unit; leg; male; medical record review; mortality; paralysis; patient; positive end expiratory pressure; quality of life; risk; surgery; surgical approach; tracheostomy; ventilated patient; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71993306
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=A+retrospective+review+of+the+spinal+fusion+outcomes+and+complications+for+a+pediatric+cohort+receiving+long-term+mechanical+ventilation+in+the+pre-operative+period&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=185&issue=&spage=&epage=&aulast=Amin&aufirst=R.&auinit=R.&aufull=Amin+R.&coden=&isbn=&pages=-&date=2012&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 592
TITLE
  Ultrasound-guided continuous paravertebral block in isolated thoracic 
trauma-providing sufficient analgesia for weaning and 
non-invasive-ventilation (NIV) on ICU for a 46 year old patient after 
high-speed trauma
AUTHOR NAMES
  Reisig F.; Buettner J.
AUTHOR ADDRESSES
  (Reisig F., florian.reisig@bgu-murnau.de; Buettner J.) BG Traumacenter 
Murnau, Department of Anaesthesiology and Intensive Care, Murnau, Bavaria, 
Germany.
CORRESPONDENCE ADDRESS
  F. Reisig, BG Traumacenter Murnau, Department of Anaesthesiology and 
Intensive Care, Murnau, Bavaria, Germany. Email: 
florian.reisig@bgu-murnau.de
FULL RECORD ENTRY DATE
  2014-01-24
SOURCE
  Ultraschall in der Medizin, Supplement (2012) 33 SUPPL. 2. Date of 
Publication: August 2012
VOLUME
  33
DATE OF PUBLICATION
  August 2012
CONFERENCE NAME
  Ultraschall 2012
CONFERENCE LOCATION
  Davos, Switzerland
CONFERENCE DATE
  2012-09-26 to 2012-09-29
ISSN
  1431-4894
BOOK PUBLISHER
  Georg Thieme Verlag
ABSTRACT
  Purpose: After acute high-velocity injury it is desirable to avoid thoracic 
epidural analgesia to povide neurological examination of the spinal cord 
function. Systemic analgesia is often insufficient to tolerante non-invasive 
ventilation (NIV) in massive thoracic trauma and often leads to reintubation 
and subsequent dilation tracheotomy. Patient and Methods: A 46 year old Pat. 
(ASA I) suffered from a high speed injury with prolonged extrincation, 
during which he required intubation and a thoracic drain. Following the 
standard trauma diagnostic in our institution (FAST & whole-body-trauma-CT) 
only a massive left sided thoraxtrauma (Rib fractures I - XI, 
haematopneumothorax and dorsal lung consolidation) could be revealed. The 
patient was scheduled for extubation and NIV. After reaching normothermia on 
ICU and good blood gas values in prone position (left side up) a continuous 
paravertebral block (cPVB) was placed in the 5th intercostalspace using 
ultrasound-guided (LAX - in-plane) technique (1) under sterile conditions 
and tunneling (2). Results: After a bolus of 10mlRopivacaine 0,375% the 
patient was turned on his back and successfully extubated 45 Minutes later 
and NIV could be supplied immediately (VAS <4). The spread of hypaesthesia 
covered the segments Th2- Th7. The continous infusion of Ropivacain 0,33% 
(8ml/h) was gradually reduced. After 5 days extensive NIV on ICU the 
catheter was paused and on the sixth day removed. The patient was then 
transfered to a normal ward. A second patient was subsequently treated 
according to the same regime two month later, which provide again a profund 
analgetic quality. Conclusion: The placement of a cPVB provided good 
analgesia for an acute isolated throax trauma. This finding is comparable to 
results derived from elective thoracic surgery (3). The spread of analgesia 
was comparable to recent findings in cadaver studies (4) and in preliminary 
clinicalsudies (5) as well. Ultrasound guided continous paravetebral 
analgesia in the hands of the experienced sonographer is an excellent 
alternative for cases where thoracic epiduralshould be avoided.
EMTREE DRUG INDEX TERMS
  analgesic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  analgesia; human; injury; noninvasive ventilation; patient; thorax injury; ultrasound; velocity; weaning; 
EMTREE MEDICAL INDEX TERMS
  blood gas; body position; body temperature; cadaver; catheter; diagnosis; epidural anesthesia; extubation; hematopneumothorax; infusion; intubation; lung; neurologic examination; rib fracture; spinal cord function; thorax surgery; tracheotomy; ward; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71297616
DOI
  10.1055/s-0032-1322739
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0032-1322739
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14314894&id=doi:10.1055%2Fs-0032-1322739&atitle=Ultrasound-guided+continuous+paravertebral+block+in+isolated+thoracic+trauma-providing+sufficient+analgesia+for+weaning+and+non-invasive-ventilation+%28NIV%29+on+ICU+for+a+46+year+old+patient+after+high-speed+trauma&stitle=Ultraschall+Med.+Suppl.&title=Ultraschall+in+der+Medizin%2C+Supplement&volume=33&issue=&spage=&epage=&aulast=Reisig&aufirst=F.&auinit=F.&aufull=Reisig+F.&coden=&isbn=&pages=-&date=2012&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 593
TITLE
  Influence of personal preferences for life-sustaining treatment on medical 
decision making among pediatric intensivists
AUTHOR NAMES
  Needle J.S.; Mularski R.A.; Nguyen T.; Fromme E.K.
AUTHOR ADDRESSES
  (Needle J.S., needlej@ohsu.edu) Division of Critical Care, Department of 
Pediatrics, Oregon Health and Science University, Portland, OR, United 
States.
(Mularski R.A.) Center for Health Research, Kaiser Permanente, Portland, OR, 
United States.
(Nguyen T.) Division of Biostatistics, Department of Public Health and 
Preventive Medicine, United States.
(Fromme E.K.) Oregon Health and Science University, Portland, OR, United 
States.
CORRESPONDENCE ADDRESS
  J.S. Needle, Division of Critical Care, Department of Pediatrics, Oregon 
Health and Science University, Portland, OR, United States. Email: 
needlej@ohsu.edu
AiP/IP ENTRY DATE
  2012-08-01
FULL RECORD ENTRY DATE
  2012-08-07
SOURCE
  Critical Care Medicine (2012) 40:8 (2464-2469). Date of Publication: August 
2012
VOLUME
  40
ISSUE
  8
FIRST PAGE
  2464
LAST PAGE
  2469
DATE OF PUBLICATION
  August 2012
ISSN
  0090-3493
  1530-0293 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  OBJECTIVES: Withholding and withdrawal of life-sustaining treatment by 
physicians is influenced by a variety of factors; the role of physicians' 
personal preferences for life-sustaining treatments has not previously been 
explored. We sought to examine the relationship between personal preferences 
for life-sustaining treatment and medical decision making among pediatric 
intensivists. DESIGN: Cross-sectional national anonymous mail survey. 
SUBJECTS: All board-certified/eligible pediatric intensivists identified by 
the American Medical Association Masterfile. INTERVENTIONS: None. 
MEASUREMENTS AND MAIN RESULTS: A total of 471 (30%) surveys were returned. A 
Personal Preference Score was calculated from responses to 
personal-preference questions for life-sustaining treatments adapted from 
"Your Life, Your Choices," by Pearlman et al. Physicians were asked to 
consider the "acceptability" of offering and recommending treatment options 
involving life-sustaining treatments in a hypothetical scenario of a 2-yr 
old with a high cervical spinal-cord transection. Logistic regression 
controlling for sociodemographic characteristics found significant 
relationships (p < .01) between physicians' own preferences modeled as a one 
standard deviation change in their own Personal Preference Score (preference 
for life-sustaining treatment) and whether they offered more or less 
aggressive care (OR [95%CI]). Physicians who had a higher Personal 
Preference Score (higher preference for their own life-sustaining treatment) 
were more likely to recommend a tracheostomy (1.38 [1.35-1.41]) and 
reintubation if the patient failed extubation (1.87 [1.81-1.94]). Pediatric 
intensivists who had a lower Personal Preference Score (lower preference for 
life-sustaining treatment) were more likely to recommend that the patient 
not be reintubated if extubation failed (1.42 [1.39-1.46]) and to recommend 
Do Not Resuscitate status (1.34 [1.31-1.37]). CONCLUSIONS: Among pediatric 
intensivists, personal preferences for life-sustaining treatment were 
significantly associated with scenario-based responses to acceptability of 
withholding and withdrawal of life-sustaining treatment. Physicians should 
be aware of the potential for personal preferences to influence practice 
recommendations, and endeavor to elicit and respect family preferences in 
collaborative decision making. Copyright © 2012 by the Society of Critical 
Care.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  life sustaining treatment; medical decision making; personal preference; 
EMTREE MEDICAL INDEX TERMS
  adult; article; critically ill patient; cross-sectional study; female; health survey; human; intubation; male; medical expert; personal preference Score; priority journal; scoring system; spinal cord transsection; tracheostomy; treatment failure; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012437110
MEDLINE PMID
  22809913 (http://www.ncbi.nlm.nih.gov/pubmed/22809913)
PUI
  L365313242
DOI
  10.1097/CCM.0b013e318255d85b
FULL TEXT LINK
  http://dx.doi.org/10.1097/CCM.0b013e318255d85b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2FCCM.0b013e318255d85b&atitle=Influence+of+personal+preferences+for+life-sustaining+treatment+on+medical+decision+making+among+pediatric+intensivists&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=40&issue=8&spage=2464&epage=2469&aulast=Needle&aufirst=Jennifer+S.&auinit=J.S.&aufull=Needle+J.S.&coden=CCMDC&isbn=&pages=2464-2469&date=2012&auinit1=J&auinitm=S
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 594
TITLE
  Electrical stimulation of accessory muscles of respiration: Is there a role 
for enhancing weaning from mechanical ventilatory support in long term acute 
care?
AUTHOR NAMES
  Gerstenhaber B.; Rosenblum D.; Kowalsky D.; Rochester C.; Palermo F.; Costigan-Humes C.; Tall L.
AUTHOR ADDRESSES
  (Gerstenhaber B.) Gaylord Hospital, Yale University, Wallingford, United 
States.
(Rosenblum D.; Kowalsky D.; Rochester C.; Palermo F.; Costigan-Humes C.; 
Tall L.) Yale University, School of Medicine, VA Connecticut Healthcare 
System, New Haven, United States.
CORRESPONDENCE ADDRESS
  B. Gerstenhaber, Gaylord Hospital, Yale University, Wallingford, United 
States.
FULL RECORD ENTRY DATE
  2015-09-08
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2012) 185 
MeetingAbstracts. Date of Publication: 2012
VOLUME
  185
DATE OF PUBLICATION
  2012
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2012
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2012-05-18 to 2012-05-23
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  We conducted a pilot study to determine whether transcutaneous Patterned 
Electrical Stimulation (PENS) of the accessory muscles of respiration could 
be tolerated and/or enhance the weaning process in patients on long-term 
mechanical ventilator support at Gaylord Hospital, a Long Term Acute Care 
Hospital (LTACH). We studied 6 patients: 1 with post-surgical respiratory 
failure, 4 with COPD and hypercarbic respiratory failure and 1 with adult 
respiratory distress. The PENS was applied to the following muscle groups: 
scalenes, upper trapezius and abdominal muscles. PENS was delivered using an 
Omnistim FX2 stimulator which delivered a train of asymmetrical biphasic 
square waves with pulse durations of 70 - 100 microseconds and current 
amplitudes of 25 to 100 milliamps. Pulses were delivered once every 1.5 
seconds. Unlike conventional electrical stimulation protocols that produce 
sustained tetanic muscle contractions, the PENS produced moderate intensity 
twitch contractions which are better tolerated than sustained contractions. 
Patients received 20 minutes of PENS to each area simultaneously, three 
times/week, until weaning success, or a maximum of 6 weeks. Stimulation was 
adjusted at each session, on an individual basis, to tolerance. Patients 
with electrical devices (pacemakers, TENS units), massive obesity and 
neuro-muscular (Spinal Cord Injury, Amyotrophic Lateral Sclerosis and 
Guillain-Barre syndrome) co-morbidities were excluded. The general weaning 
process included progressive tolerance of tracheostomy collar, in 
conjunction with standard physical, occupational and speech therapy. There 
was no evidence that the use of PENS in conjunction with our weaning program 
shortened weaning time, decreased the rate of hospital-acquired pneumonia or 
shortened length of stay compared with historical patients with similar 
conditions in our institution. However, patient tolerance of the PENS was 
excellent without complaint of pain or muscle soreness; there were no 
complications or adverse effects. Thus, while PENS of the accessory muscles 
of respiration is feasible in patients with respiratory failure, we believe 
that a larger study is necessary to further evaluate the potential efficacy 
of PENS in facilitating weaning from mechanical ventilation and to identify 
subpopulations of patients with respiratory failure who might benefit most 
from the use of this muscle training technique.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American; electrostimulation; emergency care; human; muscle; society; weaning; 
EMTREE MEDICAL INDEX TERMS
  abdominal wall musculature; adult respiratory distress syndrome; adverse drug reaction; amyotrophic lateral sclerosis; artificial ventilation; cardiac rhythm management device; devices; Guillain Barre syndrome; hospital; hospital acquired pneumonia; length of stay; mechanical ventilator; morbidity; muscle tetanic contraction; muscle training; muscle twitch; obesity; pain; patient; pilot study; pulse rate; respiratory failure; speech therapy; spinal cord injury; stimulation; tracheostomy; trapezius muscle; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71987680
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Electrical+stimulation+of+accessory+muscles+of+respiration%3A+Is+there+a+role+for+enhancing+weaning+from+mechanical+ventilatory+support+in+long+term+acute+care%3F&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=185&issue=&spage=&epage=&aulast=Gerstenhaber&aufirst=B.&auinit=B.&aufull=Gerstenhaber+B.&coden=&isbn=&pages=-&date=2012&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 595
TITLE
  Succinylcholine-induced hyperkalemia in a patient with multiple sclerosis
AUTHOR NAMES
  Levine M.; Brown D.F.M.
AUTHOR ADDRESSES
  (Levine M.) Department of Emergency Medicine, Section of Medical Toxicology, 
University of Southern California, 1200 North State Street, Los Angeles, CA 
90033, United States.
(Brown D.F.M.) Department of Emergency Medicine, Massachusetts General 
Hospital, Boston, MA, United States.
CORRESPONDENCE ADDRESS
  M. Levine, Department of Emergency Medicine, Section of Medical Toxicology, 
University of Southern California, 1200 North State Street, Los Angeles, CA 
90033, United States.
AiP/IP ENTRY DATE
  2011-12-08
FULL RECORD ENTRY DATE
  2012-08-29
SOURCE
  Journal of Emergency Medicine (2012) 43:2 (279-282). Date of Publication: 
August 2012
VOLUME
  43
ISSUE
  2
FIRST PAGE
  279
LAST PAGE
  282
DATE OF PUBLICATION
  August 2012
ISSN
  0736-4679
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background: Succinylcholine administration is associated with hyperkalemia 
in patients with a variety of medical conditions, including many 
neuromuscular disorders. Nonetheless, there is a paucity of literature 
describing hyperkalemia after the administration of succinylcholine to 
patients with multiple sclerosis. Case Report: This case report describes a 
38-year-old woman with multiple sclerosis who developed life-threatening 
hyperkalemia after the administration of succinylcholine during rapid 
sequence intubation. Conclusion: This case highlights the potential for 
iatrogenic hyperkalemia after succinylcholine in patients with neurologic 
diseases, including multiple sclerosis.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  suxamethonium (adverse drug reaction, drug therapy, intravenous drug 
administration); 
EMTREE DRUG INDEX TERMS
  baclofen (drug therapy); beta1 interferon (drug therapy); bicarbonate (drug therapy); calcium chloride (drug therapy, intravenous drug administration); cyclophosphamide (drug therapy); docusate sodium (drug therapy); etomidate (drug therapy, intravenous drug administration); glucose (drug therapy, intravenous drug administration); heparin (drug therapy, subcutaneous drug administration); hydroxychloroquine sulfate (drug therapy); insulin (drug therapy, intravenous drug administration); polystyrenesulfonate sodium (drug therapy); potassium (endogenous compound); prednisone (drug therapy, oral drug administration); ranitidine (drug therapy); steroid (drug therapy); topiramate (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  multiple sclerosis (drug therapy, drug therapy, prevention, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; ambient air; anemia (diagnosis); arm; arterial gas; article; artificial ventilation; auscultation; blood cell count; blood pressure fluctuation; carotid artery pulse; case report; cervical spinal cord injury; dermatome; disease exacerbation (drug therapy); drug dose reduction; dyspnea; electrocardiogram; end tidal carbon dioxide tension; extensor muscle; feces incontinence (complication); female; forced vital capacity; heart arrhythmia (complication); hematocrit; hemiparesis (drug therapy); hospitalization; human; hyperkalemia (drug therapy, side effect, therapy); hyporeflexia; hypoxia (diagnosis); intensive care unit; limb weakness (drug therapy); lumbar puncture; methicillin resistant Staphylococcus aureus infection (complication); muscle strength; nuclear magnetic resonance imaging; oxygen mask; oxygen saturation; oxygenation; paraplegia (complication); percutaneous endoscopic gastrostomy; pH; plasmapheresis; pneumonia (complication); potassium blood level; priority journal; QRS complex; respiratory acidosis (diagnosis); respiratory tract intubation; sensory dysfunction; sinus rhythm; tachypnea; tracheostomy; urine incontinence (complication); 
DRUG TRADE NAMES
  colace  , United StatesPurdue

  kayexalate  , United StatesSanofi Aventis

  suxamethonium
DRUG MANUFACTURERS
   (United States)Purdue
   (United States)Sanofi Aventis
CAS REGISTRY NUMBERS
  baclofen (1134-47-0)
  bicarbonate (144-55-8, 71-52-3)
  calcium chloride (10043-52-4)
  cyclophosphamide (50-18-0)
  docusate sodium (577-11-7)
  etomidate (15301-65-2, 33125-97-2, 51919-80-3)
  glucose (50-99-7, 84778-64-3)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
  hydroxychloroquine sulfate (747-36-4)
  insulin (9004-10-8)
  polystyrenesulfonate sodium (37349-16-9, 39291-70-8, 62744-35-8, 9080-79-9)
  potassium (7440-09-7)
  prednisone (53-03-2)
  ranitidine (66357-35-5, 66357-59-3)
  suxamethonium (306-40-1, 71-27-2)
  topiramate (97240-79-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012478376
MEDLINE PMID
  22142672 (http://www.ncbi.nlm.nih.gov/pubmed/22142672)
PUI
  L51749226
DOI
  10.1016/j.jemermed.2011.06.062
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jemermed.2011.06.062
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07364679&id=doi:10.1016%2Fj.jemermed.2011.06.062&atitle=Succinylcholine-induced+hyperkalemia+in+a+patient+with+multiple+sclerosis&stitle=J.+Emerg.+Med.&title=Journal+of+Emergency+Medicine&volume=43&issue=2&spage=279&epage=282&aulast=Levine&aufirst=Michael&auinit=M.&aufull=Levine+M.&coden=JEMMD&isbn=&pages=279-282&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 596
TITLE
  Annual Scientific Meeting of the Neuroanaesthesia Society of Great Britain 
and Ireland 2012
AUTHOR ADDRESSES
  FULL RECORD ENTRY DATE
  2012-08-01
SOURCE
  Journal of Neurosurgical Anesthesiology (2012) 24:3. Date of Publication: 
July 2012
VOLUME
  24
ISSUE
  3
DATE OF PUBLICATION
  July 2012
CONFERENCE NAME
  Annual Scientific Meeting of the Neuroanaesthesia Society of Great Britain 
and Ireland 2012
CONFERENCE LOCATION
  Belfast, Northern Ireland, United Kingdom
CONFERENCE DATE
  2012-05-10 to 2012-05-11
ISSN
  0898-4921
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  The proceedings contain 28 papers. The topics discussed include: 
interhemispheric EEG variability measured using a bilateral bispectral index 
(BIS) sensor; a full audit cycle of preoperative fluid fasting at the Wessex 
Neurological Center; estimating weight in neurosurgical patients with a 
raised BMI: a recipe for drug delivery errors; targeting of preoperative 
clotting studies for elective and emergency intracranial surgery; family 
satisfaction in a neurosciences intensive care unit; tracheostomies in 
patients with neurological disease: the first 10 years; a national survey on 
the use of bispectral index for sedation management in adult patients with 
traumatic brain injury; spinal clearance in unconscious children with 
traumatic brain injury: a survey of current practice in paediatric intensive 
care units of great Britain and Ireland; and bilateral bispectral index 
(BiBIS): recordings from a patient with vasospasm following clipping of a 
cerebral aneurysm.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Ireland; society; United Kingdom; 
EMTREE MEDICAL INDEX TERMS
  adult; bispectral index; brain artery aneurysm; brain surgery; child; clinical audit; diet restriction; drug delivery system; ego development; electroencephalogram; emergency; human; intensive care unit; liquid; neurologic disease; neurosurgery; patient; prescription; recording; satisfaction; sedation; sensor; tracheostomy; traumatic brain injury; vasospasm; weight; 
LANGUAGE OF ARTICLE
  English
PUI
  L70819367
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08984921&id=doi:&atitle=Annual+Scientific+Meeting+of+the+Neuroanaesthesia+Society+of+Great+Britain+and+Ireland+2012&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=24&issue=3&spage=&epage=&aulast=&aufirst=&auinit=&aufull=&coden=&isbn=&pages=-&date=2012&auinit1=&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 597
TITLE
  A single institutional experience of 42 cases of pediatric cervical spine 
trauma from India: Are they different from adult cervical trauma
AUTHOR NAMES
  Gupta D.; Prasad G.L.; Mahapatra A.K.
AUTHOR ADDRESSES
  (Gupta D.; Prasad G.L.; Mahapatra A.K.) All India Institute of Medical 
Sciences, New Delhi, India.
CORRESPONDENCE ADDRESS
  D. Gupta, All India Institute of Medical Sciences, New Delhi, India.
FULL RECORD ENTRY DATE
  2012-08-24
SOURCE
  Journal of Neurotrauma (2012) 29:10 (A80). Date of Publication: 1 Jul 2012
VOLUME
  29
ISSUE
  10
FIRST PAGE
  A80
DATE OF PUBLICATION
  1 Jul 2012
CONFERENCE NAME
  30th Annual National Neurotrauma Symposium
CONFERENCE LOCATION
  Phoenix, AZ, United States
CONFERENCE DATE
  2012-07-22 to 2012-07-25
ISSN
  0897-7151
BOOK PUBLISHER
  Mary Ann Liebert Inc.
ABSTRACT
  Introduction Pediatric cervical spine injuries are relatively uncommon and 
are associated with significant morbidity and mortality. Pediatric anatomy 
and physiology predispose to upper cervical spine injury and spinal cord 
injury without radiologic abnormality in contrast to lower cervical spine 
injury seen in adults. Falls are the most common cause of spinal trauma in 
Indian pediatric population. Children have relatively high incidence of 
upper cervical injuries due to their mobile anatomy, ligamentous laxity and 
cephalocervical disproportion. Methods Objectives: This study was carried 
out to analyse the epidemiologic profile of pediatric cervical spine 
injuries and to evaluate the clinicoradiological characteristics of cervical 
spine injuries in children, to correlate the outcome with the 
clinico-radiological features. Methodology: Prospective cum retrospective 
data analysis (2008-2011) at JPN apex trauma centre, New Delhi, India. 42 
children (0-18 yrs) were operated during this period. Fall from height was 
noted in 27 cases, upper cervical spine injuries in 12/42 cases (odontoid 
fractures in 6 cases). Associated injuries were noted in 8 cases, preop ASIA 
A score was noted in 16 cases. Two cases had prep systemic hypotension and 
required ventilator support. Methylprednisolone was not given in this 
series. All patients had CT of whole spine (as protocol) and MRI imaging 
study. Patients with whiplash/sciwora were excluded. Results Postoperative 
VAP was noted in 28 cases, 38 required tracheostomy, perioperative mortality 
noted in 2 cases. Implant failure on long term follow up seen in 2 cases 
requiring refixation in one patient. 13 of 16 children who came for follow 
up had become independent for ADL (81) at a follow up range of 4-40 months 
thereby showing significant neurological recovery in these group of 
patients. Conclusions Ligamentous injuries are commoner in pediatric 
patients, fall from height most commonly noted in Indian population, sub 
axial trauma more common than upper cervical trauma. 81 had good outcome at 
last follow up. Such observation warrants aggressive surgical approach in 
pediatric population to give them better neurological outcome.
EMTREE DRUG INDEX TERMS
  methylprednisolone; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult; cervical spine injury; India; nervous system injury; 
EMTREE MEDICAL INDEX TERMS
  child; data analysis; follow up; height; human; hypotension; imaging; implant; Indian; injury; methodology; morbidity; mortality; nuclear magnetic resonance imaging; odontoid process fracture; patient; physiology; population; spinal cord injury; spine; spine injury; surgical approach; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70837538
DOI
  10.1089/neu.2012.9943
FULL TEXT LINK
  http://dx.doi.org/10.1089/neu.2012.9943
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08977151&id=doi:10.1089%2Fneu.2012.9943&atitle=A+single+institutional+experience+of+42+cases+of+pediatric+cervical+spine+trauma+from+India%3A+Are+they+different+from+adult+cervical+trauma&stitle=J.+Neurotrauma&title=Journal+of+Neurotrauma&volume=29&issue=10&spage=A80&epage=&aulast=Gupta&aufirst=Deepak&auinit=D.&aufull=Gupta+D.&coden=&isbn=&pages=A80-&date=2012&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 598
TITLE
  Ethics: End-of-life decision-making in a pediatric patient with SMA type 2: 
The influence of the media
AUTHOR NAMES
  Drake M.; Cox P.
AUTHOR ADDRESSES
  (Drake M., madelinejdrake@gmail.com; Cox P.) Hospital for Sick Children, 
University of Toronto, Canada.
CORRESPONDENCE ADDRESS
  M. Drake, Hospital for Sick Children, University of Toronto, Canada. Email: 
madelinejdrake@gmail.com
AiP/IP ENTRY DATE
  2012-07-16
FULL RECORD ENTRY DATE
  2012-07-19
SOURCE
  Neurology (2012) 78:23 (e143-e145). Date of Publication: 5 Jun 2012
VOLUME
  78
ISSUE
  23
DATE OF PUBLICATION
  5 Jun 2012
ISSN
  0028-3878
  1526-632X (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Objective: Spinal muscular atrophy (SMA) is a group of progressive and fatal 
neurodegenerative disorders that are characterized by destruction of the 
anterior horn cells of the spinal cord. In this case report we outline the 
medical and ethical issues involved in a 7-year-old boy with SMA type 2 who 
experienced acute respiratory failure. Methods: A review of the literature 
was conducted focusing particularly on the pathology, presentation, and 
outcomes of SMA and end-of-life decision-making in pediatrics. Results: In a 
world where 40%-60% of deaths in pediatric intensive care units are a result 
of withdrawal or limitation of life-sustaining treatment, end-of-life 
decision-making has become an integral and difficult part of pediatric 
practice. Conclusion: Limitation or withdrawal of life-sustaining treatment 
in a cognitively normal child with SMA poses a significant medical and 
ethical dilemma. This difficult decision is influenced by confluence of 
parental, doctor, social, cultural, moral, religious, legal, and economic 
factors and more recently the media. Copyright © 2012 by AAN Enterprises, 
Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  end of life decision making; medical decision making; spinal muscular atrophy; terminal care; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; bradycardia; case report; child; coughing; drowsiness; dyspnea; endotracheal intubation; ethics; feeding disorder; general condition deterioration; human; hypercapnia (complication); hypopnea index; hypoventilation (therapy); lethargy; life sustaining treatment; limb weakness; male; priority journal; respiratory distress; resuscitation; school child; social media; tachypnea; tracheostomy; treatment withdrawal; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012393351
MEDLINE PMID
  22665147 (http://www.ncbi.nlm.nih.gov/pubmed/22665147)
PUI
  L365192395
DOI
  10.1212/WNL.0b013e318258f835
FULL TEXT LINK
  http://dx.doi.org/10.1212/WNL.0b013e318258f835
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00283878&id=doi:10.1212%2FWNL.0b013e318258f835&atitle=Ethics%3A+End-of-life+decision-making+in+a+pediatric+patient+with+SMA+type+2%3A+The+influence+of+the+media&stitle=Neurology&title=Neurology&volume=78&issue=23&spage=&epage=&aulast=Drake&aufirst=Madeline&auinit=M.&aufull=Drake+M.&coden=NEURA&isbn=&pages=-&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 599
TITLE
  Ultrasound-guided continuous paravertebral block in isolated thoracic 
trauma-providing sufficient analgesia for weaning and 
non-invasive-ventilation (NIV) on ICU for a 46 year old patient after 
high-speed trauma
AUTHOR NAMES
  Reisig F.; Lehner C.; Perras J.; Buettner J.
AUTHOR ADDRESSES
  (Reisig F.; Lehner C.; Perras J.; Buettner J.) BG Traumacenter Murnau, 
Department of Anaesthesiology and Intensive Care, Murnau, Germany.
CORRESPONDENCE ADDRESS
  F. Reisig, BG Traumacenter Murnau, Department of Anaesthesiology and 
Intensive Care, Murnau, Germany.
FULL RECORD ENTRY DATE
  2013-06-18
SOURCE
  European Journal of Anaesthesiology (2012) 29 SUPPL. 50 (118-119). Date of 
Publication: June 2012
VOLUME
  29
FIRST PAGE
  118
LAST PAGE
  119
DATE OF PUBLICATION
  June 2012
CONFERENCE NAME
  European Anaesthesiology Congress, EUROANAESTHESIA 2012
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2012-06-09 to 2012-06-12
ISSN
  0265-0215
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: After acute high-velocity injury it is desirable to avoid 
thoracic epidural analgesia to povide neurological examination of the spinal 
cord function. Systemic analgesia is often insufficient to tolerante 
non-invasive ventilation (NIV) in massive thoracic trauma and often leads to 
reintubation and subsequent dilation tracheotomy. Case report: A 46 year old 
Pat. (ASA I) suffered from a high speed injury with prolonged extrincation, 
during which he required intubation and a thoracic drain. Following the 
standard trauma diagnostic in our institution (FAST & hole-body-trauma-CT) 
only a massive left sided thoraxtrauma (Rib fractures I - XI, 
haematopneumothorax and dorsal lung consolidation) could be revealed. The 
patient was scheduled for extubation and NIV. After reaching normothermia on 
ICU and good blood gas values in prone position (left side up) a continuous 
paravertebral block (cPVB) was placed in the 5th intercostal space using 
ultrasound-guided (LAX - in-plane) technique (1) under sterile conditions 
and tunneling (2). After a bolus of 10ml Ropivacaine 0,375% the patient was 
turned on his back and successfully extubated 45 Minutes later and NIV could 
be supplied immediately (VAS < 4). The spread of hypaesthesia covered the 
segments Th2 - Th7. The continous infusion of Ropivacain 0,33% (8ml/h) was 
gradually reduced. After 5 days extensive NIV on ICU the catheter was paused 
and on the sixth day removed. The patient was then transfered to a normal 
ward. Discussion: The placement of a cPVB provided good analgesia for an 
acute isolated throax trauma. This finding is comparable to results derived 
from elective thoracic surgery (3). The spread of analgesia was comparable 
to recent findings in cadaver studies (4) and in preliminary clinical sudies 
(5) as well.
EMTREE DRUG INDEX TERMS
  ropivacaine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  analgesia; anesthesiology; human; injury; noninvasive ventilation; patient; thorax injury; ultrasound; velocity; weaning; 
EMTREE MEDICAL INDEX TERMS
  blood gas; body position; body temperature; cadaver; case report; catheter; diagnosis; epidural anesthesia; extubation; hematopneumothorax; infusion; intubation; lung; neurologic examination; rib fracture; spinal cord function; thorax surgery; tracheotomy; ward; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71084377
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02650215&id=doi:&atitle=Ultrasound-guided+continuous+paravertebral+block+in+isolated+thoracic+trauma-providing+sufficient+analgesia+for+weaning+and+non-invasive-ventilation+%28NIV%29+on+ICU+for+a+46+year+old+patient+after+high-speed+trauma&stitle=Eur.+J.+Anaesthesiol.&title=European+Journal+of+Anaesthesiology&volume=29&issue=&spage=118&epage=119&aulast=Reisig&aufirst=F.&auinit=F.&aufull=Reisig+F.&coden=&isbn=&pages=118-119&date=2012&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 600
TITLE
  International survey of physician recommendation for tracheostomy for spinal 
muscular atrophy Type i
AUTHOR NAMES
  Benson R.C.; Hardy K.A.; Gildengorin G.; Hsia D.
AUTHOR ADDRESSES
  (Benson R.C., rbenson@mail.cho.org; Hardy K.A.) Bay Area Pediatric Pulmonary 
Medical Corporation, Oakland, CA, United States.
(Benson R.C., rbenson@mail.cho.org; Hardy K.A.; Gildengorin G.) Children's 
Hospital and Research Center Oakland, Oakland, CA, United States.
(Hsia D.) Oregon Health and Science University, Portland, OR, United States.
CORRESPONDENCE ADDRESS
  R.C. Benson, 747 52nd St., Oakland, CA, United States. Email: 
rbenson@mail.cho.org
AiP/IP ENTRY DATE
  2011-12-16
FULL RECORD ENTRY DATE
  2012-06-07
SOURCE
  Pediatric Pulmonology (2012) 47:6 (606-611). Date of Publication: June 2012
VOLUME
  47
ISSUE
  6
FIRST PAGE
  606
LAST PAGE
  611
DATE OF PUBLICATION
  June 2012
ISSN
  8755-6863
  1099-0496 (electronic)
BOOK PUBLISHER
  Wiley-Liss Inc., 111 River Street, Hoboken, United States.
ABSTRACT
  The ethics of invasive mechanical ventilation for children with the 
neurodegenerative disease Spinal Muscular Atrophy Type I (SMA I) is highly 
debated, and wide variability in clinical outcomes exists internationally. 
We conducted this international survey to identify physician characteristics 
associated with recommendation for tracheostomy and ventilation for SMA I. A 
cross-sectional online survey was distributed to 1,772 pediatric 
pulmonologists and pediatric intensivists from online membership directories 
of American Thoracic Society, American College of Chest Physicians, and 
European Respiratory Society. Questions explored physician demographics, 
attitudes and experience with SMA and end-of-life care, knowledge of 
consensus guidelines, and recommendations for respiratory care of SMA I. A 
logistic regression model assessed the independent effects of physician 
variables on the recommendation for invasive ventilation for SMA I. A total 
of 367 (21%) physicians completed the survey; 82% were pediatric 
pulmonologists; and 16% pediatric intensivists. Seventy percent of 
respondents were from the U.S. Fifty percent of physicians were aware of SMA 
consensus guidelines. Physicians from Commonwealth countries (U.K., Canada, 
Australia, etc.) were less likely to recommend tracheostomy/ventilation than 
U.S. physicians (7% vs. 25%, P=0.005). Logistic regression modeling 
identified years of experience, pediatric pulmonology specialty, agreement 
with a pro-life statement, and recommendation for non-invasive ventilation 
as predictive of recommendation for long-term invasive ventilation for SMA 
I. In the largest international survey on this topic, we identified regional 
differences in physician recommendation for invasive ventilation for 
children with SMA I. Our data demonstrate a need for increased awareness of 
consensus guidelines and further dialog about the physician role in 
variability of care for children with SMA I. Copyright © 2011 Wiley 
Periodicals, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  practice guideline; spinal muscular atrophy; tracheostomy; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; Australia; Canada; child care; consensus; cross-sectional study; demography; female; geographic origin; health care survey; human; logistic regression analysis; long term care; male; medical specialist; normal human; physician attitude; priority journal; respiratory care; terminal care; United Kingdom; United States; work experience; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012290870
MEDLINE PMID
  22170631 (http://www.ncbi.nlm.nih.gov/pubmed/22170631)
PUI
  L51768248
DOI
  10.1002/ppul.21617
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.21617
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=87556863&id=doi:10.1002%2Fppul.21617&atitle=International+survey+of+physician+recommendation+for+tracheostomy+for+spinal+muscular+atrophy+Type+i&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=47&issue=6&spage=606&epage=611&aulast=Benson&aufirst=Ren%C3%A9e+C.&auinit=R.C.&aufull=Benson+R.C.&coden=PEPUE&isbn=&pages=606-611&date=2012&auinit1=R&auinitm=C
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 601
TITLE
  Use of Glidescope® As a first-choice technique in Klippel-Feil syndrome 
airway management
AUTHOR NAMES
  Marques J.; Henriques A.R.; Bettencourt M.; Figueiredo J.N.; Chaló D.
AUTHOR ADDRESSES
  (Marques J.; Henriques A.R.; Bettencourt M.; Figueiredo J.N.; Chaló D.) 
Hospital Infante D. Pedro, Department of Anaesthesiology, Aveiro, Portugal.
CORRESPONDENCE ADDRESS
  J. Marques, Hospital Infante D. Pedro, Department of Anaesthesiology, 
Aveiro, Portugal.
FULL RECORD ENTRY DATE
  2013-06-18
SOURCE
  European Journal of Anaesthesiology (2012) 29 SUPPL. 50 (235). Date of 
Publication: June 2012
VOLUME
  29
FIRST PAGE
  235
DATE OF PUBLICATION
  June 2012
CONFERENCE NAME
  European Anaesthesiology Congress, EUROANAESTHESIA 2012
CONFERENCE LOCATION
  Paris, France
CONFERENCE DATE
  2012-06-09 to 2012-06-12
ISSN
  0265-0215
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: Klippel-Feil syndrome (KFS) is characterized by the presence of 
a congenital synostosis of some or all of the cervical vertebrae[1] and a 
severe restriction of cervical motion that predicts difficult airway. Even 
minor distraction of the neck can be responsible for neurologic or cervical 
spine injury, so regional techniques, awake fiberoptic intubation or awake 
tracheostomy are recommended anesthetic approaches[1-2]. Case report: We 
report a case of periprosthetic femur fracture in a 23-year-old woman with 
KFS, ASA III, right congenital deafness, history of encephalocele 
complicated with meningitis after birth and dilated cardiomyopathy, due to 
high dose of doxorubicin for an osteossarcoma. Weighed 65 kg and 1,50m in 
tall. Cervical mobility limited to 15 degrees of head turn to the left, 15 
to right, and 10 of extension. Normal dentition, interincisive distance< 3 
cm, sternomental distance< 12 cm, Mallampati impossible to evaluate due to 
limited mouth opening. After institution of standard ASA monitoring, BIS and 
TOF, awake intubation was performed with remifentanil infusion 
(0,01-0,1ug/kg/min) and spontaneous ventilation maintained with FiO(2)=100% 
face mask. We use 10% lidocaine spray and then Glidescope® lamina 2 was 
inserted and glottis perfectly visualised and a 6 mm tube inserted once 
confirmed position. Anaesthesia was induced with propofol 50 mg, rocuronium 
20 mg. Maintenance with oxygen and sevoflurane (1 MAC). Femoral and 
cutaneous femoral nerve block using neurostimulator, 15 ml and 5 ml of 
Ropivacaine 0,5%, respectively. Discussion: The unavailability of a 
fiberscope and unique circumctances posed a challenge to convencional rubric 
of difficult airway algorithm and forced an alternative management using 
videolaringoscopy (Glidescope®) as first-choice technique, followed by 
periferic nerve block.
EMTREE DRUG INDEX TERMS
  anesthetic agent; doxorubicin; lidocaine; oxygen; propofol; remifentanil; rocuronium; ropivacaine; sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesiology; Klippel Feil syndrome; respiration control; 
EMTREE MEDICAL INDEX TERMS
  aerosol; airway; algorithm; anesthesia; breathing; case report; cervical spine; cervical spine injury; congenital deafness; congestive cardiomyopathy; dentition; drug megadose; encephalocele; face mask; female; femoral nerve; femur fracture; fiber optics; fiberoscope; glottis; human; infusion; intubation; meningitis; monitoring; neck; nerve block; synostosis; tracheostomy; tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71084773
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02650215&id=doi:&atitle=Use+of+Glidescope%C2%AE+As+a+first-choice+technique+in+Klippel-Feil+syndrome+airway+management&stitle=Eur.+J.+Anaesthesiol.&title=European+Journal+of+Anaesthesiology&volume=29&issue=&spage=235&epage=&aulast=Marques&aufirst=J.&auinit=J.&aufull=Marques+J.&coden=&isbn=&pages=235-&date=2012&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 602
TITLE
  A case of myofibrillary myopathy associated with rigid spine syndrome
AUTHOR NAMES
  Liew W.K.; Chai J.
AUTHOR ADDRESSES
  (Liew W.K.; Chai J.) Singapore, Singapore.
CORRESPONDENCE ADDRESS
  W.K. Liew, Singapore, Singapore.
FULL RECORD ENTRY DATE
  2012-08-10
SOURCE
  Clinical Neurophysiology (2012) 123:6 (e66). Date of Publication: June 2012
VOLUME
  123
ISSUE
  6
FIRST PAGE
  e66
DATE OF PUBLICATION
  June 2012
CONFERENCE NAME
  58th Annual Meeting of the American Association of Neuromuscular and 
Electrodiagnostic Medicine
CONFERENCE LOCATION
  San Francisco, CA, United States
CONFERENCE DATE
  2011-09-14 to 2011-09-17
ISSN
  1388-2457
BOOK PUBLISHER
  Elsevier Ireland Ltd
ABSTRACT
  Introduction: This is a case of an 11-month-old Cambodian boy, third child 
born to nonconsanguionous parents, who was previously well. He developed an 
acute onset of respiratory distress with lethargy following an upper 
respiratory illness, requiring intubation and ventilatory support. At 
presentation, he was noted to have marked spine and abdominal muscle 
rigidity with mild peripheral hypotonia of his limbs. He was initially 
treated empirically for meningoencephalitis and subsequently tetanus with no 
improvement of his symptoms. Objectives: To describe the clinical 
presentation of myofibrillar myopathy. Results: Brain magnetic resonance 
imaging was normal. His serum creatine kinase was mildly raised at 1000. 
Echocardiography showed mild septal hypertrophy of the heart. Needle 
electromyography (EMG) showed myopathic features and his muscle biopsy 
showed the presence of eosinophilic hyaline bodies on hematoxylin and eosin 
staining with suggestion of inter-myofibrillary disruption on modified 
Gomori-Trichrome and Verhoff-Van Gieson stains. He remained dependent on 
ventilator support and underwent a tracheostomy during his admission. 
Conclusion: This is a case of myofibrillar myopathy associated with rigid 
spine syndrome, respiratory insufficiency, and mild cardiomyopathy. 
Diagnosis was made with muscle biopsy and needle EMG findings.
EMTREE DRUG INDEX TERMS
  eosin; hematoxylin; hyalin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myopathy; spine; 
EMTREE MEDICAL INDEX TERMS
  abdominal wall musculature; boy; brain; Cambodian; cardiomyopathy; child; creatine kinase blood level; diagnosis; echocardiography; electromyogram; electromyography; heart; human; hypertrophy; intubation; lethargy; limb; male; meningoencephalitis; muscle biopsy; muscle hypotonia; muscle rigidity; needle; nuclear magnetic resonance imaging; parent; respiratory distress; respiratory failure; respiratory tract disease; stain; staining; tetanus; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70824779
DOI
  10.1016/j.clinph.2011.11.252
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clinph.2011.11.252
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13882457&id=doi:10.1016%2Fj.clinph.2011.11.252&atitle=A+case+of+myofibrillary+myopathy+associated+with+rigid+spine+syndrome&stitle=Clin.+Neurophysiol.&title=Clinical+Neurophysiology&volume=123&issue=6&spage=e66&epage=&aulast=Liew&aufirst=W.K.&auinit=W.K.&aufull=Liew+W.K.&coden=&isbn=&pages=e66-&date=2012&auinit1=W&auinitm=K
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 603
TITLE
  Vital capacity in spinal muscular atrophy.
AUTHOR NAMES
  Bach J.R.; Tuccio M.C.; Khan U.; Saporito L.R.
AUTHOR ADDRESSES
  (Bach J.R.) Department of Physical Medicine and Rehabilitation, University 
Hospital B-403, 150 Bergen Street, Newark, NJ, USA.
(Tuccio M.C.; Khan U.; Saporito L.R.)
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine and Rehabilitation, University 
Hospital B-403, 150 Bergen Street, Newark, NJ, USA.
FULL RECORD ENTRY DATE
  2012-07-25
SOURCE
  American journal of physical medicine & rehabilitation / Association of 
Academic Physiatrists (2012) 91:6 (487-493). Date of Publication: Jun 2012
VOLUME
  91
ISSUE
  6
FIRST PAGE
  487
LAST PAGE
  493
DATE OF PUBLICATION
  Jun 2012
ISSN
  1537-7385 (electronic)
ABSTRACT
  This work describes and correlates plateau/maximum observed vital capacity 
(VC) with spinal muscular atrophy (SMA) severity and prognosis for 
autonomous breathing. SMA severity was correlated with VC, onset, 
paradoxical breathing, age at definitive dependence on continuous mechanical 
ventilation (DDCV), and age at first respiratory hospitalization and 
gastrostomy. Ten severe SMA 1A patients with DDCV before 6 mos of age had 
maximum observed and plateau VC of 100 ml or less, with plateaus for six at 
10.3 (range, 3-48) mos. Another 120 had typical SMA 1B defined by any three 
of the following: acute respiratory failure before 12 mos of age, 
gastrostomy before 12 mos of age, DDCV before 10 yrs of age, and VC not 
exceeding 200 ml, with plateaus for 15 at 26.4 (6-138) mos. Fifteen were 
with mild type 1C defined by three of the following: VC exceeding 200 ml, 
acute respiratory failure after 1 yr of age, gastrostomy after 1 yr of age, 
and no DDCV before 10 yrs of age and had a plateau/maximum observed mean VC 
of 409 (range, 200-1175) ml at 8.9 (range, 7-10) yrs of age. Of 88 patients 
with SMA 2 and paradoxical breathing (2A), 16 had a mean plateau/maximum 
observed VC of 758 (range, 460-2100) ml. DDCV with no autonomous breathing 
always followed plateauing of VC. Types 2B, 3, and 4 patients attained 
normal VC. Intergroup VC differences were significant (P < 0.05) for 1A, 1B, 
1C, 2A, and 2B-4. When intubated and "unweanable," 50-ml VC signaled the 
ability for autonomous breathing 1 to 21 days after extubation. VC should be 
monitored from birth. It correlates with prognosis with SMA 1A VCs not 
exceeding 100 ml or 1B 200 ml. Patients who attained 200 ml at any time 
(milder 1C) retain some ability to breathe after 10 yrs of age.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cause of death; hereditary spinal muscular atrophy (diagnosis, therapy); vital capacity; 
EMTREE MEDICAL INDEX TERMS
  age; article; artificial ventilation; child; comparative study; disease course; female; hospitalization; human; infant; longitudinal study; lung function test; male; methodology; mortality; multimodality cancer therapy; nonparametric test; physiology; preschool child; prognosis; retrospective study; statistics; survival; tracheostomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  22469873 (http://www.ncbi.nlm.nih.gov/pubmed/22469873)
PUI
  L365270505
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15377385&id=doi:&atitle=Vital+capacity+in+spinal+muscular+atrophy.&stitle=Am+J+Phys+Med+Rehabil&title=American+journal+of+physical+medicine+%26+rehabilitation+%2F+Association+of+Academic+Physiatrists&volume=91&issue=6&spage=487&epage=493&aulast=Bach&aufirst=John+R&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=487-493&date=2012&auinit1=J&auinitm=R
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 604
TITLE
  Airway Management in Neuroanesthesiology
AUTHOR NAMES
  Aziz M.
AUTHOR ADDRESSES
  (Aziz M., azizm@ohsu.edu) Department of Anesthesiology and Perioperative 
Medicine, Oregon Health and Science University, Mail Code KPV 5A, 3181 SW 
Sam Jackson Park Road, Portland, OR 97239, United States.
CORRESPONDENCE ADDRESS
  M. Aziz, Department of Anesthesiology and Perioperative Medicine, Oregon 
Health and Science University, Mail Code KPV 5A, 3181 SW Sam Jackson Park 
Road, Portland, OR 97239, United States. Email: azizm@ohsu.edu
AiP/IP ENTRY DATE
  2012-08-30
FULL RECORD ENTRY DATE
  2012-09-05
SOURCE
  Anesthesiology Clinics (2012) 30:2 (229-240). Date of Publication: June 2012
VOLUME
  30
ISSUE
  2
FIRST PAGE
  229
LAST PAGE
  240
DATE OF PUBLICATION
  June 2012
ISSN
  1932-2275
  2210-3538 (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Airway management for neuroanesthesiology brings together some key 
principles that are shared throughout neuroanesthesiology. This article 
appropriately targets the cervical spine with associated injury and the 
challenges surrounding airway management. The primary focus of this article 
is on the unique airway management obstacles encountered with cervical spine 
injury or cervical spine surgery, and unique considerations regarding 
functional neurosurgery are addressed. Furthermore, topics related to 
difficult airway management for those with rheumatoid arthritis or pituitary 
surgery are reviewed. © 2012 Elsevier Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; respiration control; 
EMTREE MEDICAL INDEX TERMS
  acromegaly; airway obstruction; anesthesist; blunt trauma; breathing; cervical spine radiography; clinical practice; computer assisted tomography; endotracheal intubation; extubation; fluoroscopy; general anesthesia; glottis; head injury; human; hypophysis; laryngoscopy; neurosurgery; oxygen saturation; patient positioning; review; rheumatoid arthritis; spinal cord; spine surgery; stereotaxic surgery; surgical patient; surgical technique; tracheostomy; treatment contraindication; 
DEVICE TRADE NAMES
  Airtraq  Prodol Meditec

  AWS  Pentax

  Bullard  Circon Acmi

  GlideScope  Trachlight

  GlideScope  Verathon

  WuScope  Pentax

DEVICE MANUFACTURERS
  Circon Acmi
  Pentax
  Prodol Meditec
  Trachlight
  Verathon
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012495388
MEDLINE PMID
  22901608 (http://www.ncbi.nlm.nih.gov/pubmed/22901608)
PUI
  L365491244
DOI
  10.1016/j.anclin.2012.04.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.anclin.2012.04.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19322275&id=doi:10.1016%2Fj.anclin.2012.04.001&atitle=Airway+Management+in+Neuroanesthesiology&stitle=Anesthesiol.+Clin.&title=Anesthesiology+Clinics&volume=30&issue=2&spage=229&epage=240&aulast=Aziz&aufirst=Michael&auinit=M.&aufull=Aziz+M.&coden=&isbn=&pages=229-240&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 605
TITLE
  Electrophrenic pacing and decannulation for high-level spinal cord injury: A 
case series
AUTHOR NAMES
  Bolikal P.; Bach J.R.; Goncalves M.
AUTHOR ADDRESSES
  (Bolikal P.; Bach J.R., bachjr@umdnj.edu) Department of Physical Medicine 
and Rehabilitation, University of Medicine and Dentistry of New Jersey-New 
Jersey Medical School, University Hospital B-403, 150 Bergen Street, Newark, 
NJ 07103, United States.
(Goncalves M.) Department of Pulmonology, University Hospital of S. João, 
University of Porto, Portugal.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine and Rehabilitation, University of 
Medicine and Dentistry of New Jersey-New Jersey Medical School, University 
Hospital B-403, 150 Bergen Street, Newark, NJ 07103, United States. Email: 
bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2012-05-07
SOURCE
  Journal of Spinal Cord Medicine (2012) 35:3 (170-174). Date of Publication: 
2012
VOLUME
  35
ISSUE
  3
FIRST PAGE
  170
LAST PAGE
  174
DATE OF PUBLICATION
  2012
ISSN
  1079-0268
  2045-7723 (electronic)
BOOK PUBLISHER
  Maney Publishing, Suite 1C, Joseph's Well, Hanover Walk, Leeds, United 
Kingdom.
ABSTRACT
  Background: In 1997, guidelines were developed for the management of 
high-level ventilator-dependent patients with spinal cord injury who had 
little or no ventilator-free breathing ability (VFBA). This article 
describes the three categories of patients, the decannulation criteria, and 
the successful decannulation of four patients with no VFBA and 
electrophrenic/diaphragm pacing, using these criteria. Method: Case series. 
Conclusion: Lack of VFBA in patients with high-level spinal cord injury does 
not mandate tracheostomy or electrophrenic/diaphragm pacing. © The Academy 
of Spinal Cord Injury Professionals, Inc. 2012.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; breathing; case report; chronic bronchitis; coughing; female; glossopharyngeal nerve; human; lung compliance; male; quadriplegia; respiratory arrest; tracheostomy; ventilator; ventilator free breathing ability; vital capacity; 
DEVICE TRADE NAMES
  Lipseal  , United StatesPhillips

DEVICE MANUFACTURERS
   (United States)Phillips
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012234583
MEDLINE PMID
  22333657 (http://www.ncbi.nlm.nih.gov/pubmed/22333657)
PUI
  L364677562
DOI
  10.1179/2045772311Y.0000000056
FULL TEXT LINK
  http://dx.doi.org/10.1179/2045772311Y.0000000056
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1179%2F2045772311Y.0000000056&atitle=Electrophrenic+pacing+and+decannulation+for+high-level+spinal+cord+injury%3A+A+case+series&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=35&issue=3&spage=170&epage=174&aulast=Bolikal&aufirst=Priya&auinit=P.&aufull=Bolikal+P.&coden=JSCMC&isbn=&pages=170-174&date=2012&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 606
TITLE
  Tracheotomy and children with spinal muscular atrophy type 1: Ethical 
considerations in the French context
AUTHOR NAMES
  Rul B.; Carnevale F.; Estournet B.; Rudler M.; Hervé C.
AUTHOR ADDRESSES
  (Rul B., brigitte.rul@rpc.aphp.fr; Estournet B.) Raymond Poincaré Hospital, 
France.
(Rul B., brigitte.rul@rpc.aphp.fr) Paris-Descartes University, France.
(Carnevale F.) Montreal Children's Hospital, Canada.
(Estournet B.) Versailles Saint-Quentin-en-Yvelines University, France.
(Rudler M.; Hervé C.) Paris-Descartes University, France.
CORRESPONDENCE ADDRESS
  B. Rul, Hôpital Raymond Poincaré, Pediatric Intensive Care Unit, Letulle 3, 
104, Boulevard R. Poincaré, 92380 Garches, France. Email: 
brigitte.rul@rpc.aphp.fr
FULL RECORD ENTRY DATE
  2012-09-10
SOURCE
  Nursing Ethics (2012) 19:3 (408-418). Date of Publication: May 2012
VOLUME
  19
ISSUE
  3
FIRST PAGE
  408
LAST PAGE
  418
DATE OF PUBLICATION
  May 2012
ISSN
  0969-7330
  1477-0989 (electronic)
BOOK PUBLISHER
  SAGE Publications Ltd, 55 City Road, London, United Kingdom.
ABSTRACT
  Spinal muscular atrophy (SMA) type 1 is a genetic neuromuscular disease in 
children that leads to degeneration of spinal cord motor neurons. This 
sometimes results in severe muscular paralysis requiring mechanical 
ventilation to sustain the child's life. The onset of SMA type 1, the most 
severe form of the disease, is during the first year of life. These children 
become severely paralysed, but retain their intellectual capacity. Ethical 
concerns arise when mechanical ventilation becomes necessary for survival. 
When professionals assess the resulting life for the child and family, they 
sometimes fear it will result in unreasonably excessive care. The aim of 
this article is to present an analysis of ethical arguments that could 
support or oppose the provision of invasive ventilation in this population. 
This examination is particularly relevant as France is one of the few 
countries performing tracheotomies and mechanical ventilation for this 
condition. © The Author(s) 2012.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hereditary spinal muscular atrophy (therapy); nursing care; patient care; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; classification; ethics; France; hospitalization; human; human relation; infant; informed consent; legal aspect; morality; mortality; newborn; onset age; pathology; personal autonomy; practice guideline; preschool child; standard; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  22323397 (http://www.ncbi.nlm.nih.gov/pubmed/22323397)
PUI
  L364955265
DOI
  10.1177/0969733011429014
FULL TEXT LINK
  http://dx.doi.org/10.1177/0969733011429014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09697330&id=doi:10.1177%2F0969733011429014&atitle=Tracheotomy+and+children+with+spinal+muscular+atrophy+type+1%3A+Ethical+considerations+in+the+French+context&stitle=Nurs.+Ethics&title=Nursing+Ethics&volume=19&issue=3&spage=408&epage=418&aulast=Rul&aufirst=Brigitte&auinit=B.&aufull=Rul+B.&coden=&isbn=&pages=408-418&date=2012&auinit1=B&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 607
TITLE
  Childhood spinal muscular atrophy: Controversies and challenges
AUTHOR NAMES
  Mercuri E.; Bertini E.; Iannaccone S.T.
AUTHOR ADDRESSES
  (Mercuri E.) Pediatric Neurology Unit, Catholic University, Rome, Italy.
(Bertini E.) Department of Neuroscience, Unit of Neuromuscular Disorders, 
Laboratory of Molecular Medicine, Bambino Gesù Hospital, Rome, Italy.
(Iannaccone S.T., susan.iannaccone@utsouthwestern.edu) Pediatric Neurology, 
Children's Medical Center Ambulatory Care Pavilion in Dallas, University of 
Texas Southwestern Medical Center, Dallas, TX, United States.
CORRESPONDENCE ADDRESS
  S.T. Iannaccone, Professor of Neurology and Pediatrics, University of Texas, 
Southwestern Medical Center, Dallas, TX 75390-9063, United States. Email: 
susan.iannaccone@utsouthwestern.edu
AiP/IP ENTRY DATE
  2012-04-25
FULL RECORD ENTRY DATE
  2012-04-27
SOURCE
  The Lancet Neurology (2012) 11:5 (443-452). Date of Publication: May 2012
VOLUME
  11
ISSUE
  5
FIRST PAGE
  443
LAST PAGE
  452
DATE OF PUBLICATION
  May 2012
ISSN
  1474-4422
  1474-4465 (electronic)
BOOK PUBLISHER
  Lancet Publishing Group, 84 Theobald's Road, London, United Kingdom.
ABSTRACT
  Spinal muscular atrophy is an autosomal recessive disorder characterised by 
degeneration of motor neurons in the spinal cord and is caused by mutations 
of the survival of motor neuron 1 gene SMN1. The severity of spinal muscular 
atrophy is highly variable and no cure is available at present. Consensus 
has been reached on several aspects of care, the availability of which can 
have a substantial effect on prognosis, but controversies remain. The 
development of standards of care for children with the disorder and the 
identification of promising treatment strategies have changed the natural 
history of spinal muscular atrophy, and the prospects are good for further 
improvements in function, quality of life, and survival. A long-term benefit 
for patients will be the development of effective interventions (such as 
antisense oligonucleotides), some of which are in clinical trials. The need 
to be prepared for clinical trials has been the impetus for a remarkable and 
unprecedented cooperation between clinicians, scientists, industry, 
government, and volunteer organisations on an international scale. © 2012 
Elsevier Ltd.
EMTREE DRUG INDEX TERMS
  survival motor neuron protein 1 (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood disease (diagnosis, epidemiology, therapy); spinal muscular atrophy (diagnosis, epidemiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; childbirth; creatine kinase blood level; diagnostic test; disease classification; early diagnosis; electromyography; family counseling; gene deletion; gene insertion; gene mutation; gene sequence; genetic counseling; genetic screening; health care cost; health care quality; human; hypoventilation (therapy); incidence; life sustaining treatment; nerve conduction; nutrition; osteoporosis; outcome assessment; oximetry; palliative therapy; parenteral nutrition; patient assessment; physical examination; pregnancy; priority journal; quality of life; respiratory function; review; scoliosis (surgery); sensitivity and specificity; sequence analysis; spine fusion; tracheostomy; translational research; vital capacity; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Human Genetics (22)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012221906
MEDLINE PMID
  22516079 (http://www.ncbi.nlm.nih.gov/pubmed/22516079)
PUI
  L364641641
DOI
  10.1016/S1474-4422(12)70061-3
FULL TEXT LINK
  http://dx.doi.org/10.1016/S1474-4422(12)70061-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14744422&id=doi:10.1016%2FS1474-4422%2812%2970061-3&atitle=Childhood+spinal+muscular+atrophy%3A+Controversies+and+challenges&stitle=Lancet+Neurol.&title=The+Lancet+Neurology&volume=11&issue=5&spage=443&epage=452&aulast=Mercuri&aufirst=Eugenio&auinit=E.&aufull=Mercuri+E.&coden=LNAEA&isbn=&pages=443-452&date=2012&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 608
TITLE
  Total arch and descending thoracic aortic replacement by left thoracotomy
AUTHOR NAMES
  Corvera J.S.; Fehrenbacher J.W.
AUTHOR ADDRESSES
  (Corvera J.S., jcorvera@iuhealth.org; Fehrenbacher J.W.) Indiana University 
Health Cardiovascular Surgeons, Methodist Hospital, 1801 N Senate Blvd, 
Indianapolis, IN 46202, United States.
CORRESPONDENCE ADDRESS
  J.S. Corvera, Indiana University Health Cardiovascular Surgeons, Methodist 
Hospital, 1801 N Senate Blvd, Indianapolis, IN 46202, United States. Email: 
jcorvera@iuhealth.org
AiP/IP ENTRY DATE
  2012-05-07
FULL RECORD ENTRY DATE
  2012-05-09
SOURCE
  Annals of Thoracic Surgery (2012) 93:5 (1510-1516). Date of Publication: May 
2012
VOLUME
  93
ISSUE
  5
FIRST PAGE
  1510
LAST PAGE
  1516
DATE OF PUBLICATION
  May 2012
ISSN
  0003-4975
  1552-6259 (electronic)
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background: The hybrid treatment of transverse aortic arch pathologies with 
supraaortic debranching and endovascular repair is associated with 
significant morbidity and death and lacks long-term follow-up. The 
traditional two-stage open surgical approach to extensive arch and 
descending thoracic aneurysms carries a significant interval mortality rate. 
We report the results of a single-stage technique of total arch and 
descending thoracic aortic replacement by a left thoracotomy. Methods: From 
January 1995 to February 2011, 426 patients underwent thoracic or 
thoracoabdominal aneurysm repair, of which a highly selected group of 27 
patients underwent total arch replacement with descending thoracic or 
thoracoabdominal aortic replacement. All procedures were performed with 
hypothermic circulatory arrest and selective antegrade cerebral perfusion. 
Two patients required transverse division of the sternum. Two patients had 
emergency or urgent operations. Five patients had concomitant coronary 
artery bypass, and 1 had concomitant mitral valve replacement. Results: 
There were no hospital deaths, no cerebrovascular accidents, and one 
instance of transient spinal cord ischemia. Three patients had acute renal 
failure not requiring hemodialysis. Intubation in 5 patients exceeded 48 
hours, and 1 patient needed tracheostomy. Two patients required 
reexploration for postoperative bleeding. Survival at 1, 3, and 5 years was 
95%, 78%, and 73%, respectively. Conclusions: Replacement of the total arch 
and descending thoracic aorta by a left thoracotomy provides excellent 
short-term and long-term results for the treatment of extensive arch and 
thoracic aortic pathology, without the need for a second-stage operation. 
Other cardiac pathologies, such as left-sided coronary disease and mitral 
valve disease, can be addressed concurrently. © 2012 The Society of Thoracic 
Surgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic arch surgery; brain perfusion; deep hypothermic circulatory arrest; descending aortic surgery; thoracic aorta aneurysm (surgery); thoracotomy; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure; adult; aged; article; coronary artery bypass graft; female; human; major clinical study; male; mitral valve replacement; mortality; postoperative hemorrhage; priority journal; spinal cord ischemia; sternum; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012236961
MEDLINE PMID
  22459546 (http://www.ncbi.nlm.nih.gov/pubmed/22459546)
PUI
  L364685654
DOI
  10.1016/j.athoracsur.2012.01.098
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2012.01.098
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2Fj.athoracsur.2012.01.098&atitle=Total+arch+and+descending+thoracic+aortic+replacement+by+left+thoracotomy&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=93&issue=5&spage=1510&epage=1516&aulast=Corvera&aufirst=Joel+S.&auinit=J.S.&aufull=Corvera+J.S.&coden=ATHSA&isbn=&pages=1510-1516&date=2012&auinit1=J&auinitm=S
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 609
TITLE
  Spinal muscular atrophy type 1: Are proactive respiratory interventions 
associated with longer survival?
AUTHOR NAMES
  Lemoine T.J.; Swoboda K.J.; Bratton S.L.; Holubkov R.; Mundorff M.; Srivastava R.
AUTHOR ADDRESSES
  (Lemoine T.J., tara.lemoine@hsc.utah.edu; Swoboda K.J.; Bratton S.L.; 
Holubkov R.; Srivastava R.) Department of Pediatrics, University of Utah 
School of Medicine, Salt Lake City, UT, United States.
(Swoboda K.J.) Department of Neurology, University of Utah School of 
Medicine, Salt Lake City, UT, United States.
(Mundorff M.) Department of Intermountain Healthcare, Salt Lake City, UT, 
United States.
CORRESPONDENCE ADDRESS
  T.J. Lemoine, Department of Pediatrics, University of Utah School of 
Medicine, Salt Lake City, UT, United States. Email: 
tara.lemoine@hsc.utah.edu
AiP/IP ENTRY DATE
  2011-12-28
FULL RECORD ENTRY DATE
  2012-05-30
SOURCE
  Pediatric Critical Care Medicine (2012) 13:3 (e161-e165). Date of 
Publication: May 2012
VOLUME
  13
ISSUE
  3
DATE OF PUBLICATION
  May 2012
ISSN
  1529-7535
  1947-3893 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  CONTEXT: Spinal muscular atrophy type 1, an autosomal recessive motor neuron 
disease, is a leading genetic cause of death in infancy and early childhood. 
OBJECTIVE: To determine whether the early initiation of noninvasive 
respiratory interventions is associated with longer survival. DESIGN: 
Single-institution retrospective cohort study identified children with 
spinal muscular atrophy type 1 from January 1, 2002 to May 1, 2009 who were 
followed for 2.3 mean yrs. SETTING: Tertiary care children's hospital and 
outpatient clinics in a vertically integrated healthcare system. PATIENTS OR 
OTHER PARTICIPANTS: Forty-nine children with spinal muscular atrophy type 1 
were grouped according to the level of respiratory support their caregivers 
chose within the first 3 months after diagnosis: proactive respiratory care 
(n = 26) and supportive care (n = 23). INTERVENTIONS: Proactive respiratory 
care included bilevel noninvasive ventilation during sleep and twice a day 
cough assist while supportive respiratory care included suctioning, with or 
without supplemental oxygen. MEASUREMENTS AND MAIN RESULTS: Kaplan-Meier 
survival curves were assessed based on intention to treat. Children treated 
with early proactive respiratory support had statistically longer survival 
compared to supportive care (log rank 0.047); however, the adjusted hazard 
ratio for survival was not statistically different (2.44 [95% confidence 
interval 0.84-7.1]). Children in the proactive group were more likely to be 
hospitalized for respiratory insufficiency (83% vs. 46%) and had shortened 
time after diagnosis until first hospital admission for respiratory 
insufficiency (median 118 vs. 979 days). CONCLUSION: Longer survival time 
with spinal muscular atrophy type 1 is associated with early, noninvasive 
respiratory care interventions after diagnosis. Copyright © 2012 by the 
Society of Critical Care Medicine and the World Federation of Pediatric 
Intensive and Critical Care Societies.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  childhood disease (disease management, therapy); respiratory care; spinal muscular atrophy (disease management, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; caregiver; clinical article; cohort analysis; female; follow up; health care cost; hospital admission; hospital care; human; infant; male; oxygen therapy; priority journal; respiratory failure (therapy); retrospective study; survival; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012282830
MEDLINE PMID
  22198810 (http://www.ncbi.nlm.nih.gov/pubmed/22198810)
PUI
  L51784471
DOI
  10.1097/PCC.0b013e3182388ad1
FULL TEXT LINK
  http://dx.doi.org/10.1097/PCC.0b013e3182388ad1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15297535&id=doi:10.1097%2FPCC.0b013e3182388ad1&atitle=Spinal+muscular+atrophy+type+1%3A+Are+proactive+respiratory+interventions+associated+with+longer+survival%3F&stitle=Pediatr.+Crit.+Care+Med.&title=Pediatric+Critical+Care+Medicine&volume=13&issue=3&spage=&epage=&aulast=Lemoine&aufirst=Tara+J.&auinit=T.J.&aufull=Lemoine+T.J.&coden=&isbn=&pages=-&date=2012&auinit1=T&auinitm=J
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 610
TITLE
  Noninvasive respiratory management for patients with spinal cord injury and 
neuromuscular disease
AUTHOR NAMES
  Bach J.R.; Bakshiyev R.; Hon A.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu) Department of Neurosciences, UMDNJ-New Jersey 
Medical School, Center for Ventilator Management Alternatives University 
Hospital, Newark, NJ, United States.
(Bakshiyev R.; Hon A.) Department of Physical Medicine and Rehabilitation, 
UMDNJ-New Jersey Medical School, United States.
CORRESPONDENCE ADDRESS
  J. R. Bach, Department of Neurosciences, UMDNJ New Jersey Medical School, 
Center for Ventilator Management Alternatives University Hospital, Newark, 
NJ, United States. Email: bachjr@umdnj.edu
AiP/IP ENTRY DATE
  2012-03-30
FULL RECORD ENTRY DATE
  2012-04-05
SOURCE
  Tanaffos (2012) 11:1 (7-11). Date of Publication: 2012
VOLUME
  11
ISSUE
  1
FIRST PAGE
  7
LAST PAGE
  11
DATE OF PUBLICATION
  2012
ISSN
  1735-0344
BOOK PUBLISHER
  Shaheed Beheshti Uni. of Medical Sci. and Health Services, P.O. Box 
19575/154, Tehran, Iran.
ABSTRACT
  The purpose of this article is to describe noninvasive respiratory 
management for patients with neuromuscular respiratory muscle dysfunction 
(NMD) and spinal cord injury (SCI) and the role of electrophrenic pacing 
(EPP) and diaphragm pacing (DP) in this respect. Long term outcomes will be 
reviewed and the use of noninvasive intermittent positive pressure 
ventilation (NIV), MAC, and EPP/DP to prevent pneumonia and acute 
respiratory failure, to facilitate extubation, and to avoid tracheotomy will 
be evaluated. Although ventilator dependent patients with most NMDs and high 
level SCI can be indefinitely managed noninvasively, most ALS patients can 
be managed for a limited time by continuous NIV before tracheostomy is 
necessary for survival. Glossopharyngeal breathing (GPB) can be learned by 
patients without any autonomous breathing ability and used by them in the 
event of ventilator/EPP/DP failure or loss of interface access. EPP/DP can 
maintain alveolar ventilation for high level SCI patients when they cannot 
grab a mouth piece to use NIV. © 2012 NRITLD, National Research Institute of 
Tuberculosis and Lung Disease, Iran.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  electrophrenic pacing; neuromuscular disease (therapy); neuromuscular respiratory muscle dysfunction (therapy); non invasive procedure; phrenic nerve pacing; spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; breathing pattern; diphragm pacing; electrostimulation; glossopharyngeal breathing; human; intermittent positive pressure ventilation; long term care; lung ventilation; mechanically assisted coughing; outcome assessment; oximetry; oxygen saturation; phrenic pacing; positive end expiratory pressure; review; spirometry; ventilator; 
DEVICE TRADE NAMES
  Exsufflation Belt
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012173104
PUI
  L364493835
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17350344&id=doi:&atitle=Noninvasive+respiratory+management+for+patients+with+spinal+cord+injury+and+neuromuscular+disease&stitle=Tanaffos&title=Tanaffos&volume=11&issue=1&spage=7&epage=11&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=7-11&date=2012&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 611
TITLE
  Acute treatment options for spinal cord injury
AUTHOR NAMES
  Markandaya M.; Stein D.M.; Menaker J.
AUTHOR ADDRESSES
  (Markandaya M., mmarkandaya@umm.edu) Department of Neurology, Neuro/Trauma 
Critical Care, University of Maryland, R Adams Cowley Shock Trauma Center, 
22 S Greene Street S4D13, Baltimore, MD 21201, United States.
(Stein D.M., dstein@umm.edu) Department of Surgery/Program in Trauma, 
University of Maryland, R Adams Cowley Shock Trauma Center, 22 S Greene St, 
Baltimore, MD 21201, United States.
(Menaker J., jmenaker@umm.edu) Department of Emergency Medicine/Trauma, 
University of Maryland, R Adams Cowley Shock Trauma Center, 22 S Greene St, 
Baltimore, MD 21201, United States.
CORRESPONDENCE ADDRESS
  M. Markandaya, Department of Neurology, Neuro/Trauma Critical Care, 
University of Maryland, R Adams Cowley Shock Trauma Center, 22 S Greene 
Street S4D13, Baltimore, MD 21201, United States. Email: mmarkandaya@umm.edu
AiP/IP ENTRY DATE
  2012-02-21
FULL RECORD ENTRY DATE
  2012-06-06
SOURCE
  Current Treatment Options in Neurology (2012) 14:2 (175-187). Date of 
Publication: April 2012
VOLUME
  14
ISSUE
  2
FIRST PAGE
  175
LAST PAGE
  187
DATE OF PUBLICATION
  April 2012
ISSN
  1092-8480
  1534-3138 (electronic)
BOOK PUBLISHER
  Current Science Ltd, 34-42 Cleveland Street, London, United Kingdom.
ABSTRACT
  Most treatment options for acute traumatic spinal cord injury (SCI) are 
directed at minimizing progression of the initial injury and preventing 
secondary injury. Failure to adhere to certain guiding principles can be 
detrimental to the long-term neurologic and functional outcome of these 
patients. Therapy for the hyperacute phase of traumatic SCI focuses on 
stabilizing vital signs and follows the Advanced Trauma Life Support (ATLS) 
algorithm for ensuring stability of airway, breathing and circulation, and 
disability (neurologic evaluation)-with spinal stabilization-and exposure. 
Spinal stabilization, with cervical collars and long backboards, is used to 
prevent movement of a potentially unstable spinal column injury to prevent 
further injury to the spinal cord and nerve roots, especially during 
prehospital transport. Surgery to stabilize the spine is undertaken after 
life-threatening injuries (hemorrhage, evacuation of intracranial 
hemorrhage, acute vascular compromise) are addressed. Intensive care unit 
(ICU) admission is to be considered for all patients with high SCI or 
hemodynamic instability, as well as those with other injuries that 
independently warrant ICU admission. Avoidance of hypotension and hypoxia 
may minimize secondary neurologic injury. Elevating the mean arterial 
pressure above 85 mmHg for 7 days should be considered, to allow for spinal 
cord perfusion. The use of intravenous steroids (methylprednisolone) is 
controversial. Early tracheostomy in patients with lesions above C5 may 
reduce the number of ventilator days and the incidence of 
ventilator-associated pneumonia. Select patients may benefit from the 
placement of a diaphragmatic pacer. Aggressive measures, including 
CoughAssist and Intermittent Positive Pressure Breaths (IPPB), should be 
used to maintain lung recruitment and aid in the mobilization of secretions. 
Some patients with high SCI who are dependent onmechanical ventilation can 
eventually be liberated fromthe ventilator with consistent efforts from both 
the patient and the caregiver, along with some patience. Intermittent 
catheterization by the patient or a caregiver may be associated with a lower 
incidence of urinary tract infections, compared with an in-dwelling urinary 
catheter. Early mobilization of patients and a multidisciplinary approach 
(including respiratory therapists, nutritional experts, physical therapists, 
and occupational therapists) can streamline care and may improve long-term 
outcomes. A number of investigational drugs and therapies offer hope of 
neurologic recovery for some patients. © Springer Science+Business Media, 
LLC 2012.
EMTREE DRUG INDEX TERMS
  atropine (drug therapy, intravenous drug administration); baclofen (drug therapy); benzodiazepine derivative (drug therapy, intravenous drug administration); corticosteroid (adverse drug reaction, drug therapy, intravenous drug 
administration); enoxaparin (adverse drug reaction, drug comparison, drug therapy, 
pharmacoeconomics, subcutaneous drug administration); gabapentin (drug therapy); glycopyrronium (drug therapy, intravenous drug administration); heparin (drug comparison, drug therapy, subcutaneous drug administration); hypertensive factor (drug therapy); low molecular weight heparin (adverse drug reaction, drug therapy); methylprednisolone (adverse drug reaction, drug therapy, intravenous drug 
administration, pharmacoeconomics); midodrine (drug therapy, oral drug administration); minocycline; nonsteroid antiinflammatory agent (drug therapy); noradrenalin (drug therapy); phenylephrine (drug therapy); pregabalin (drug therapy); riluzole; salbutamol (drug therapy, oral drug administration); sodium chloride; vasodilator agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (drug therapy, diagnosis, disease management, drug 
therapy, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  artery catheter; article; artificial ventilation; assistive technology device; autonomic dysreflexia (drug therapy); bleeding disorder (side effect); bradycardia (drug therapy); computed tomographic angiography; cost effectiveness analysis; deep vein thrombosis (drug therapy); diaphragmatic pacer; diet therapy; drug cost; exercise; gastrointestinal hemorrhage (side effect); hospital admission; human; hyperglycemia (side effect); hypotension (drug therapy); indwelling catheter; infection (side effect); intensive care unit; intermittent catheterization; lifestyle modification; lung embolism (complication, disease management, drug therapy, prevention); mobilization; myelography; neuropathic pain (drug therapy); occupational therapy; physiotherapist; physiotherapy; psychosis (side effect); spinal cord decompression; spinal hematoma (complication, disease management, drug therapy, prevention); spine stabilization; spine surgery; tracheostomy; urinary tract infection (complication); vena cava filter; ventilator; ventilator associated pneumonia (complication); 
DEVICE TRADE NAMES
  CoughAssist
  Intermittent Positive Pressure Breaths
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  baclofen (1134-47-0)
  enoxaparin (679809-58-6)
  gabapentin (60142-96-3)
  glycopyrronium bromide (596-51-0)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
  methylprednisolone (6923-42-8, 83-43-2)
  midodrine (3092-17-9, 42794-76-3)
  minocycline (10118-90-8, 11006-27-2, 13614-98-7)
  noradrenalin (1407-84-7, 51-41-2)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
  pregabalin (148553-50-8)
  riluzole (1744-22-5)
  salbutamol (18559-94-9, 35763-26-9)
  sodium chloride (7647-14-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012281043
PUI
  L51843684
DOI
  10.1007/s11940-011-0162-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s11940-011-0162-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10928480&id=doi:10.1007%2Fs11940-011-0162-5&atitle=Acute+treatment+options+for+spinal+cord+injury&stitle=Curr.+Treat.+Options+Neurol.&title=Current+Treatment+Options+in+Neurology&volume=14&issue=2&spage=175&epage=187&aulast=Markandaya&aufirst=Manjunath&auinit=M.&aufull=Markandaya+M.&coden=CTONB&isbn=&pages=175-187&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 612
TITLE
  Safety of recurrent laryngeal nerve (RLN) and spinal accessory nerve (SAN) 
dissections
AUTHOR NAMES
  Romanchishen A.F.; Romanchishen F.A.; Karpatsky I.V.
AUTHOR ADDRESSES
  (Romanchishen A.F.; Romanchishen F.A.; Karpatsky I.V.) Saint-Petersburg 
Center of Endocrine Surgery, Saint-Petersburg, Russian Federation.
CORRESPONDENCE ADDRESS
  A.F. Romanchishen, Saint-Petersburg Center of Endocrine Surgery, 
Saint-Petersburg, Russian Federation.
FULL RECORD ENTRY DATE
  2012-07-23
SOURCE
  European Archives of Oto-Rhino-Laryngology (2012) 269:4 (1340). Date of 
Publication: April 2012
VOLUME
  269
ISSUE
  4
FIRST PAGE
  1340
DATE OF PUBLICATION
  April 2012
CONFERENCE NAME
  5th European Conference on Head and Neck Oncology
CONFERENCE LOCATION
  Poznan, Poland
CONFERENCE DATE
  2012-04-18 to 2012-04-21
ISSN
  0937-4477
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background: The RLN and SAN are the most frequently damaged vital structures 
in thyroid cancer (TC) surgery. Methods: 20,113 patients underwent surgery 
during the period between 1973 and 2005. Postoperative unilateral RLN injury 
took place in 1.18%, bilateral injures in 0.42% of cases. Most often, this 
complication was observed in patients with recurrent toxic goiter (1.70%) 
and diffuse toxic goiter (1.56%). In 2,390 TC patients, RLN injury was 
observed only in 0.31% due to accurate dissection of this nerve. That 
motivated us to perform RLN dissection in every thyroid operation. There are 
about 30 variants of anatomic relations between RLN and inferior thyroid 
artery, and three most common points of RLN visualization. They are: (a) 
subclavial point known as Lore's triangle, (b) RLN “cross point” with the 
inferior thyroid artery, and (c) RLN laryngeal entry point. To improve our 
knowledge of RLN surgical anatomy, we investigated autopsy material; video 
documented 937 RLNs, and used the Nerve Integrity Monitoring during thyroid 
surgery (2001-2005). Results: It was found that RLNs in 3rd point (entry 
point) were crossed by blood vessels in 94.9% of cases. In every fourth 
observation vessels crossed the RLN from below. Ligation and transsection of 
those vessels was very important, because thyroid tissue removal became more 
convenient. The diameter (1-3 mm) of the vessels increasing from nodular 
euthyroid goitre to TC and Graves's disease. We preferred to find RLN and 
started to dissect it from below. Since RLN and ITA crossing became visually 
controlled, branches of the ITA were accessible for ligation and the 
parathyroid glands could be dissected and saved easily. Our technique of 
thyroidectomy allowed finding and saving of 15 nonrecurrent laryngeal nerves 
among 4,070 thyroid patients. Surgical tactics in case of RLN injury 
assumed: revision, restoration of RLN, and tracheostomy through the lower 
flap of the wound in bilateral laryngeal palsy cases. In 11 cases, RLN was 
restored with suturing under the EMG control. Of six patients followed up 
for 1-2 years postoperatively, four demonstrated vocal cord function 
improvement. To protect SAN during MRND, its surgical separation was 
performed. For safety reasons, the best place for the first nerve 
visualization was the upper third level of sternocleidomastoid muscle's 
(SCMM) where it accompanied the internal jugular vein (IJV). In 85.2% SAN 
laid laterally and in front of the vein, in 11.1%-behind, and in 
3.7%-medially to IJV. Then in 88.9% SAN perforated the SCMM and in 11.1% 
passed adjacent to it. The most common site of SAN exit out from the SCMM 
was approximately on the border of the upper and middle third of the SCMM 
(74.1%), in 20.4% it was in the SCMM upper third, and in 5.6% it was in the 
lower one. Our technique assumes dissection of SAN from the above with 
separating and saving of nervous branches to SCMM, C3 and. During the 
dissection, the nerve integrity and function was confirmed using 
electromyography monitoring. We also used a zigzag shaped incision for that 
kind of surgery. Conclusions: As a result of regular use of suggested RLN 
and SAN dissection techniques, the postoperative morbidity rate was 
significantly reduced.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  accessory nerve; dissection; neck; oncology; recurrent laryngeal nerve; safety; 
EMTREE MEDICAL INDEX TERMS
  artery; autopsy; blood vessel; cancer surgery; electromyogram; electromyography; goiter; Graves disease; human; incision; injury; internal jugular vein; laryngeal nerve; ligation; monitoring; morbidity; nerve; paralysis; parathyroid gland; patient; sternocleidomastoid muscle; surgery; surgical anatomy; thyroid cancer; thyroid gland; thyroid surgery; thyroidectomy; tissues; toxic goiter; tracheostomy; vein; videorecording; vocal cord; wound; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70812993
DOI
  10.1007/s00405-012-1960-4
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00405-012-1960-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09374477&id=doi:10.1007%2Fs00405-012-1960-4&atitle=Safety+of+recurrent+laryngeal+nerve+%28RLN%29+and+spinal+accessory+nerve+%28SAN%29+dissections&stitle=Eur.+Arch.+Oto-Rhino-Laryngol.&title=European+Archives+of+Oto-Rhino-Laryngology&volume=269&issue=4&spage=1340&epage=&aulast=Romanchishen&aufirst=A.F.&auinit=A.F.&aufull=Romanchishen+A.F.&coden=&isbn=&pages=1340-&date=2012&auinit1=A&auinitm=F
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 613
TITLE
  A pain in the neck: An uncommon cause for sepsis
AUTHOR NAMES
  Baiduc B.Y.; Bhat S.; Arabelo H.; Matti-Orozco B.
AUTHOR ADDRESSES
  (Baiduc B.Y.; Bhat S.; Arabelo H.; Matti-Orozco B.) Geriatric Medicine, St. 
Luke's Roosevelt Hospital Center, University College of Physicians and 
Surgeons, New York, United States.
CORRESPONDENCE ADDRESS
  B.Y. Baiduc, Geriatric Medicine, St. Luke's Roosevelt Hospital Center, 
University College of Physicians and Surgeons, New York, United States.
FULL RECORD ENTRY DATE
  2012-05-16
SOURCE
  Journal of the American Geriatrics Society (2012) 60 SUPPL. 4 (S137-S138). 
Date of Publication: April 2012
VOLUME
  60
FIRST PAGE
  S137
LAST PAGE
  S138
DATE OF PUBLICATION
  April 2012
CONFERENCE NAME
  2012 Annual Scientific Meeting of the American Geriatrics Society
CONFERENCE LOCATION
  Seattle, WA, United States
CONFERENCE DATE
  2012-05-03 to 2012-05-05
ISSN
  0002-8614
BOOK PUBLISHER
  Blackwell Publishing Inc.
ABSTRACT
  The elderly are more susceptible to infection and sepsis with a higher risk 
of morbidity and mortality. This is a case of an 86-year-old man who 
presented with 3-4 days of deteriorating mentation, fevers and generalized 
weakness. He was independent and ambulatory at baseline. As per his 
daughter, he had been bedbound a few days prior to admission. On 
presentation he was febrile, delirious, A&Ox1, and with neck stiffness 
without focal neurological findings. Chest X-Ray showed patchy infiltrates. 
CT head was negative. A lumbar puncture was refused by his family. Empiric 
treatment was started for pneumonia and possible meningitis. Blood cultures 
revealed MSSA bacteremia. Despite broad antibiotic coverage his fever and 
leukocytosis persisted and on hospital day 3 he was found quadriplegic. 
Concerns about epidural abscess and cord compression prompted an urgent 
cspine MRI which showed a ventral epidural abscess in the retroodontoid 
region with severe spinal canal compromise. Neurosurgery and Ortho Spine 
consults recommended non-operative medical treatment due to its location and 
the unlikelihood of reversing any deficits given the duration of symptoms. 
The patient continued to deteriorate, got intubated due to respiratory 
failure, and eventually, was discharged with a tracheostomy and a PEG tube. 
He was only able to “twitch” his left shoulder, fingers and toes. Epidural 
abscesses are rare and most commonly occur in the true epidural space 
located posterior and lateral to the spinal cord. The dura mater is adherent 
to the vertebral body anteriorly and the potential space in this area is 
unlikely for abscesses to form. Also, epidural abscesses occur more 
frequently in the thoraco-lumbar area due to the larger space. Diagnosing 
this patient was challenging due to the very atypical location of his 
abscess. I addition, pneumonia and delirium confounded the clinical picture 
giving a plausible explanation for the presentation. Treatment is preferably 
surgical or interventional; however, the location of his abscess made this 
difficult to perform. Furthermore, any intervention should be done within 
the first 24 hours of hospitalization. If paralysis is seen for 36-48 hours 
then medical therapy is fully acceptable. In conclusion, the clinical 
presentation of epidural abscesses is often non-specific and should be 
investigated in atypical scenarios.
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  geriatrics; neck; pain; sepsis; society; 
EMTREE MEDICAL INDEX TERMS
  abscess; aged; bacteremia; blood culture; compression; daughter; delirium; dura mater; epidural abscess; epidural space; fever; hospital; hospitalization; human; infection; leukocytosis; lumbar puncture; male; meningitis; methicillin susceptible Staphylococcus aureus; morbidity; mortality; neurosurgery; nuclear magnetic resonance imaging; paralysis; patient; pneumonia; respiratory failure; rigidity; risk; shoulder; spinal cord; spine; therapy; thinking; thorax radiography; toe; tracheostomy; tube; vertebra body; vertebral canal; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70737805
DOI
  10.1111/j.1532-5415.2012.04000.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1532-5415.2012.04000.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00028614&id=doi:10.1111%2Fj.1532-5415.2012.04000.x&atitle=A+pain+in+the+neck%3A+An+uncommon+cause+for+sepsis&stitle=J.+Am.+Geriatr.+Soc.&title=Journal+of+the+American+Geriatrics+Society&volume=60&issue=&spage=S137&epage=S138&aulast=Baiduc&aufirst=B.Y.&auinit=B.Y.&aufull=Baiduc+B.Y.&coden=&isbn=&pages=S137-S138&date=2012&auinit1=B&auinitm=Y
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 614
TITLE
  Perfluorodecalin lavage of a longstanding lung atelectasis in a child with 
spinal muscle atrophy
AUTHOR NAMES
  Henrichsen T.; Lindenskov P.H.H.; Shaffer T.H.; Loekke R.J.V.; Fugelseth D.; Lindemann R.
AUTHOR ADDRESSES
  (Henrichsen T.; Lindenskov P.H.H.) Department of Pediatrics, Pediatric 
Intensive Care Unit, Oslo University Hospital, Oslo, Norway.
(Shaffer T.H.) Department of Physiology and Pediatrics, Temple University, 
School of Medicine, Philadelphia, PA, United States.
(Loekke R.J.V.) Department of Pediatric Radiology, University of Oslo, Oslo 
University Hospital HF Ulleval, Oslo, Norway.
(Fugelseth D.; Lindemann R., roli@uus.no) Department of Neonatal Intensive 
Care, University of Oslo, Oslo University Hospital HF Ulleval, NO-0407 Oslo, 
Norway.
CORRESPONDENCE ADDRESS
  R. Lindemann, Department of Neonatal Intensive Care, University of Oslo, 
Oslo University Hospital HF Ulleval, NO-0407 Oslo, Norway. Email: 
roli@uus.no
AiP/IP ENTRY DATE
  2011-10-21
FULL RECORD ENTRY DATE
  2012-04-06
SOURCE
  Pediatric Pulmonology (2012) 47:4 (415-419). Date of Publication: April 2012
VOLUME
  47
ISSUE
  4
FIRST PAGE
  415
LAST PAGE
  419
DATE OF PUBLICATION
  April 2012
ISSN
  8755-6863
  1099-0496 (electronic)
BOOK PUBLISHER
  Wiley-Liss Inc., 111 River Street, Hoboken, United States.
ABSTRACT
  Objective Persistent lung atelectasis is difficult to treat and 
perfluorochemical (PFC) liquid may be an option for bronchioalveolar lavage 
(BAL). Case report A 4-year-old girl with spinal muscle atrophy was admitted 
in respiratory failure. On admission, the X-ray confirmed the persistence of 
total right-sided lung atelectasis, which had been present for 14 months. 
She was endotracheally intubated and ventilated from the day of admission. 
BAL with normal saline was performed twice without improvement. Following 
failed extubation and being dependent on continuous respiratory support, a 
trial of BAL using PFC liquid (Perfluorodecalin HP) was carried out. The PFC 
was delivered through the endotracheal tube on three consecutive days. A 
loading dose of 3 ml/kg was administered, followed by a varying dose in 
order to more effectively lavage the lungs. She tolerated the procedure well 
the first 2 days, although there were no clinical signs of improvement in 
the atelectasis. Intentionally, higher inflation pressures were applied 
after PFC instillation on day 3. Chest X-ray then showed hazy infiltrates on 
her left lung and she required more ventilatory support. However, lung 
infiltrates cleared over the next 3 days. A tracheotomy was done 6 days 
after the last PFC instillation. She had a slow recovery and was 
successfully decanulated. Clinical improvement of lung function was seen 
including less need of BiPAP and oxygen. A chest CT scan showed then 
functional lung tissue appearing in the previous total atelectatic right 
lung. Conclusion Lavage with PFC can safely be performed with a therapeutic 
effect in a child with unilateral total lung atelectasis. Pediatr Pulmonol. 
2012; 47:415-419. © 2011 Wiley Periodicals, Inc.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  perfluorodecalin; 
EMTREE DRUG INDEX TERMS
  antibiotic agent; cefotaxime; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atelectasis (therapy); lung lavage; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  airway pressure; arterial carbon dioxide tension; arterial pressure; article; artificial ventilation; bronchoscopy; carbon dioxide tension; case report; child; computer assisted tomography; disease duration; disease severity; endotracheal intubation; extubation; female; hospital admission; human; Human respiratory syncytial virus; lung function; lung infiltrate; lung inflation; oxygen saturation; positive end expiratory pressure; priority journal; respiratory failure (therapy); Staphylococcus hominis; thorax radiography; tracheotomy; 
CAS REGISTRY NUMBERS
  cefotaxime (63527-52-6, 64485-93-4)
  oxygen (7782-44-7)
  perfluorodecalin (306-94-5)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012181175
MEDLINE PMID
  22006656 (http://www.ncbi.nlm.nih.gov/pubmed/22006656)
PUI
  L51675223
DOI
  10.1002/ppul.21565
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.21565
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=87556863&id=doi:10.1002%2Fppul.21565&atitle=Perfluorodecalin+lavage+of+a+longstanding+lung+atelectasis+in+a+child+with+spinal+muscle+atrophy&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=47&issue=4&spage=415&epage=419&aulast=Henrichsen&aufirst=Thore&auinit=T.&aufull=Henrichsen+T.&coden=PEPUE&isbn=&pages=415-419&date=2012&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 615
TITLE
  Surgical tracheostomy in morbidly obese patients: Technical considerations 
and a two-flap technique for access
AUTHOR NAMES
  Khoo S.G.; Rajaretnam N.
AUTHOR ADDRESSES
  (Khoo S.G., sgkhoo@hotmail.com; Rajaretnam N.) Department of Otolaryngology 
- Head and Neck Surgery, Mater University Hospital, Dublin, Ireland.
CORRESPONDENCE ADDRESS
  S.G. Khoo, St. Joseph's Ward, Mater University Hospital, Dublin 7, Ireland. 
Email: sgkhoo@hotmail.com
AiP/IP ENTRY DATE
  2012-04-05
FULL RECORD ENTRY DATE
  2012-04-09
SOURCE
  Journal of Laryngology and Otology (2012) 126:4 (435-438). Date of 
Publication: April 2012
VOLUME
  126
ISSUE
  4
FIRST PAGE
  435
LAST PAGE
  438
DATE OF PUBLICATION
  April 2012
ISSN
  0022-2151
  1748-5460 (electronic)
BOOK PUBLISHER
  Cambridge University Press, Shaftesbury Road, Cambridge, United Kingdom.
ABSTRACT
  Objective: In an era in which percutaneous tracheostomies are frequently 
performed in 'suitable' necks, more technically complex cases are referred 
to the otolaryngologist. We describe the surgical technique used and close 
cooperation required in securing the airway of a morbidly obese patient. 
Case report: A 52-year-old, morbidly obese man with significant 
comorbidities was referred for surgical tracheostomy following spinal 
fractures. This was complicated by a previous percutaneous dilatational 
tracheostomy scar. Tension-free skin advancement was not possible with a 
deeply plunging trachea; a vertical skin incision was dropped inferiorly to 
the sternum for access. A size 8 Shiley XLT Proximal Extension cuffed 
tracheostomy tube was inserted successfully. Conclusion: We describe safe 
airway surgery in a morbidly obese man, and outline requirements including 
the use of a specially designed operating table, the need for an elongated 
proximal limb tracheostomy tube, and the use of a distal two-flap technique 
for access to a deeply plunging trachea. © JLO (1984) Limited 2012.
EMTREE DRUG INDEX TERMS
  corticosteroid (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; morbid obesity; spine fracture (side effect, side effect); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; chronic obstructive lung disease; coronary artery disease; corticosteroid therapy; human; hypertension; long term care; lumbar vertebra; male; non insulin dependent diabetes mellitus; obesity hypoventilation syndrome; respiratory arrest; respiratory failure; skin incision; skin scar (complication); sleep disordered breathing; smoking; surgical technique; vertebra; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012186035
MEDLINE PMID
  22284768 (http://www.ncbi.nlm.nih.gov/pubmed/22284768)
PUI
  L364534522
DOI
  10.1017/S0022215111003380
FULL TEXT LINK
  http://dx.doi.org/10.1017/S0022215111003380
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00222151&id=doi:10.1017%2FS0022215111003380&atitle=Surgical+tracheostomy+in+morbidly+obese+patients%3A+Technical+considerations+and+a+two-flap+technique+for+access&stitle=J.+Laryngol.+Otol.&title=Journal+of+Laryngology+and+Otology&volume=126&issue=4&spage=435&epage=438&aulast=Khoo&aufirst=S.G.&auinit=S.G.&aufull=Khoo+S.G.&coden=JLOTA&isbn=&pages=435-438&date=2012&auinit1=S&auinitm=G
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 616
TITLE
  Massive hematomyelia following intramedullary spinal cord tumor surgery
AUTHOR NAMES
  Shofty B.; Roth J.; Ben-Sira L.; Brotchi J.; Korn A.; Constantini S.
AUTHOR ADDRESSES
  (Shofty B.; Roth J.; Korn A.; Constantini S., sconsts@netvision.net.il) 
Department of Pediatric Neurosurgery, Tel-Aviv Medical Center, 6th Weizman 
St., Tel-Aviv, Israel.
(Ben-Sira L.) Unit of Pediatric Radiology, Tel-Aviv Medical Center, 
Tel-Aviv, Israel.
(Brotchi J.) Department of Neurosurgery, Erasme Hospital, University of 
Brussels, Brussels, Belgium.
CORRESPONDENCE ADDRESS
  S. Constantini, Department of Pediatric Neurosurgery, Tel-Aviv Medical 
Center, 6th Weizman St., Tel-Aviv, Israel. Email: sconsts@netvision.net.il
AiP/IP ENTRY DATE
  2012-07-02
FULL RECORD ENTRY DATE
  2012-07-04
SOURCE
  Acta Neurochirurgica (2012) 154:4 (751-752). Date of Publication: April 2012
VOLUME
  154
ISSUE
  4
FIRST PAGE
  751
LAST PAGE
  752
DATE OF PUBLICATION
  April 2012
ISSN
  0001-6268
  0942-0940 (electronic)
BOOK PUBLISHER
  Springer Wien, Sachsenplatz 4-6, P.O. Box 89, Vienna, Austria.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intramedullary spinal cord tumor (surgery); spinal cord surgery; spinal cord tumor (surgery); spinal hematoma (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; backache; case report; collapse; human; letter; lung sarcoidosis; male; motor dysfunction; nuclear magnetic resonance imaging; paraplegia; priority journal; quadriplegia; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2012358073
MEDLINE PMID
  22270531 (http://www.ncbi.nlm.nih.gov/pubmed/22270531)
PUI
  L365080692
DOI
  10.1007/s00701-012-1274-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00701-012-1274-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016268&id=doi:10.1007%2Fs00701-012-1274-8&atitle=Massive+hematomyelia+following+intramedullary+spinal+cord+tumor+surgery&stitle=Acta+Neurochir.&title=Acta+Neurochirurgica&volume=154&issue=4&spage=751&epage=752&aulast=Shofty&aufirst=B.&auinit=B.&aufull=Shofty+B.&coden=ACNUA&isbn=&pages=751-752&date=2012&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 617
TITLE
  Regional anesthesia with a single spinal anesthesia using hyperbaric 
bupivacaine in a child with arthroglyposis multiplex congenita
AUTHOR NAMES
  Borazan H.; Okesli S.; Uluer M.S.; Sahin O.
AUTHOR ADDRESSES
  (Borazan H., borazanh@hotmail.com; Okesli S.; Uluer M.S.; Sahin O.) 
Department of Anesthesiology and Reanimation, Medical Faculty, Selcuk 
University, Akyokus, Meram, Konya, Turkey.
CORRESPONDENCE ADDRESS
  H. Borazan, Department of Anesthesiology and Reanimation, Medical Faculty, 
Selcuk University, Akyokus, Meram, Konya, Turkey. Email: 
borazanh@hotmail.com
AiP/IP ENTRY DATE
  2012-02-23
FULL RECORD ENTRY DATE
  2012-07-16
SOURCE
  Journal of Anesthesia (2012) 26:2 (283-285). Date of Publication: April 2012
VOLUME
  26
ISSUE
  2
FIRST PAGE
  283
LAST PAGE
  285
DATE OF PUBLICATION
  April 2012
ISSN
  0913-8668
  1438-8359 (electronic)
BOOK PUBLISHER
  Springer Japan, 1-11-11 Kudan-kita, Chiyoda-ku, No. 2 Funato Bldg., Tokyo, 
Japan.
ABSTRACT
  Arthrogryposis multiplex congenita (AMC) consists of complex congenital 
anomalies characterized by multiple contractures. Anesthetic management of 
these patients requires special care: as this disease often progresses until 
dysfunction of multiple organ systems occur, it may have an impact on the 
anesthetic management. Here, we report a case of AMC undergoing urgent 
surgery for open tibia fracture who had difficult airway management because 
of limited mouth opening. The anesthetic management of this patient is 
represented in light of the literature. © 2011 Japanese Society of 
Anesthesiologists.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  bupivacaine (drug combination); 
EMTREE DRUG INDEX TERMS
  acetic acid plus dipotassium hydrogen phosphate plus glucose plus magnesium 
chloride plus potassium chloride; atropine; ephedrine; fentanyl (drug combination); ketamine (oral drug administration); lidocaine; midazolam; paracetamol (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arthrogryposis (congenital disorder, diagnosis, surgery, therapy); regional anesthesia; spinal anesthesia; 
EMTREE MEDICAL INDEX TERMS
  airway obstruction (therapy); article; case report; child; endotracheal intubation; human; hyperbaric oxygen therapy; hyperbarism; jaw malformation; joint contracture; laryngoscopy; male; oxygen saturation; postoperative pain (complication, drug therapy); preschool child; respiratory tract intubation; scoliosis; tibia fracture (surgery); tracheostomy; treatment failure; 
DRUG TRADE NAMES
  marcaine  , United StatesAstra Zeneca

DRUG MANUFACTURERS
   (United States)Astra Zeneca
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  bupivacaine (18010-40-7, 2180-92-9, 38396-39-3, 55750-21-5)
  ephedrine (299-42-3, 50-98-6)
  fentanyl (437-38-7)
  ketamine (1867-66-9, 6740-88-1, 81771-21-3)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  paracetamol (103-90-2)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Anesthesiology (24)
  Arthritis and Rheumatism (31)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012378480
MEDLINE PMID
  22354670 (http://www.ncbi.nlm.nih.gov/pubmed/22354670)
PUI
  L51874624
DOI
  10.1007/s00540-011-1309-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00540-011-1309-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09138668&id=doi:10.1007%2Fs00540-011-1309-y&atitle=Regional+anesthesia+with+a+single+spinal+anesthesia+using+hyperbaric+bupivacaine+in+a+child+with+arthroglyposis+multiplex+congenita&stitle=J.+Anesth.&title=Journal+of+Anesthesia&volume=26&issue=2&spage=283&epage=285&aulast=Borazan&aufirst=Hale&auinit=H.&aufull=Borazan+H.&coden=JOANE&isbn=&pages=283-285&date=2012&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 618
TITLE
  Dysfunction of the diaphragm
AUTHOR NAMES
  McCool F.D.; Tzelepis G.E.
AUTHOR ADDRESSES
  (McCool F.D., f_mccool@brown.edu) Department of Pulmonary, Critical Care, 
and Sleep Medicine, Memorial Hospital of Rhode Island, 111 Brewster St., 
Pawtucket, RI 02860, United States.
(McCool F.D., f_mccool@brown.edu) Warren Alpert Medical School of Brown 
University, Providence, RI, United States.
(Tzelepis G.E.) Department of Pathophysiology, University of Athens Medical 
School, Athens, Greece.
CORRESPONDENCE ADDRESS
  F.D. McCool, Department of Pulmonary, Critical Care, and Sleep Medicine, 
Memorial Hospital of Rhode Island, 111 Brewster St., Pawtucket, RI 02860, 
United States. Email: f_mccool@brown.edu
AiP/IP ENTRY DATE
  2012-03-14
FULL RECORD ENTRY DATE
  2012-03-21
SOURCE
  New England Journal of Medicine (2012) 366:10 (932-942). Date of 
Publication: 8 Mar 2012
VOLUME
  366
ISSUE
  10
FIRST PAGE
  932
LAST PAGE
  942
DATE OF PUBLICATION
  8 Mar 2012
ISSN
  0028-4793
  1533-4406 (electronic)
BOOK PUBLISHER
  Massachussetts Medical Society, 860 Winter Street, Waltham, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm disease (complication, diagnosis, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  atelectasis (diagnosis); breathing pattern; clinical feature; diaphragm paralysis (complication, diagnosis); disease association; dyspnea; echography; electromyography; endotracheal intubation; fluoroscopy; functional electrical stimulation; hemidiaphragm; human; hyperinflation; inspiratory capacity; nerve injury (complication); phrenic nerve; priority journal; prognosis; respiratory failure (complication); review; sleep disordered breathing (complication); spinal cord injury; surgical approach; thorax radiography; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2012133835
MEDLINE PMID
  22397655 (http://www.ncbi.nlm.nih.gov/pubmed/22397655)
PUI
  L364378131
DOI
  10.1056/NEJMra1007236
FULL TEXT LINK
  http://dx.doi.org/10.1056/NEJMra1007236
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00284793&id=doi:10.1056%2FNEJMra1007236&atitle=Dysfunction+of+the+diaphragm&stitle=New+Engl.+J.+Med.&title=New+England+Journal+of+Medicine&volume=366&issue=10&spage=932&epage=942&aulast=McCool&aufirst=F.+Dennis&auinit=F.D.&aufull=McCool+F.D.&coden=NEJMA&isbn=&pages=932-942&date=2012&auinit1=F&auinitm=D
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 619
TITLE
  Resolution of tracheostomy complications by decanulation and conversion to 
noninvasive management for a patient with high-level tetraplegia
AUTHOR NAMES
  Toki A.; Hanayama K.; Ishikawa Y.
AUTHOR ADDRESSES
  (Toki A.) Department of Rehabilitation, Kansai Rosai Hospital, Amagasaki, 
Hyogo, Japan.
(Hanayama K.) Department of Rehabilitation Medicine, Tokai University School 
of Medicine, Isehara, Kanagawa, Japan.
(Ishikawa Y.) Department of Paediatrics, National Organization Yakumo 
Hospital, Yakumo, Hokkaido, Japan.
CORRESPONDENCE ADDRESS
  A. Toki, Department of Rehabilitation, Kansai Rosai Hospital, Amagasaki, 
Hyogo, Japan.
AiP/IP ENTRY DATE
  2012-04-24
FULL RECORD ENTRY DATE
  2012-04-27
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2012) 18:2 (193-196). Date of 
Publication: 1 Mar 2012
VOLUME
  18
ISSUE
  2
FIRST PAGE
  193
LAST PAGE
  196
DATE OF PUBLICATION
  1 Mar 2012
ISSN
  1082-0744
  1945-5763 (electronic)
BOOK PUBLISHER
  Thomas Land Publishers Inc., 255 Jefferson Road, St. Louis, United States.
ABSTRACT
  Objectives: To report conversion from tracheostomy (TIV) to noninvasive 
intermittente positive pressure ventilation (NIV) for a continuously 
ventilator-dependent patient with high-level spinal cord injury (SCI) with 
no measurable vital capacity (VC = 0 mL) to resolve tracheostomy-associated 
complications. Methods: A case report of a 38-year-old female in a chronic 
care facility in Japan with a 10-year history of ventilator-dependent 
tetraplegia (C1 ASIA-A) presented for increasing difficulty vocalizing. She 
had been using a fenestrated cuffed tracheostomy tube to produce speech with 
the cuff defiated. Speech was increasingly hypophonic, because of 
tracheostoma enlargement, tube migration, and tracheal granulation. Results: 
The NIV was provided via nasal and oral interfaces, the ostomy was 
surgically closed, and vocalization resumed. Airway secretions were expulsed 
using manually assisted coughing. The patient returned to the community. 
Conclusion: Conversion to NIV should be considered for ventilator-dependent 
patients with SCI who have adequate bulbar-innervated muscle function to 
permit effective speech and assisted coughing. © 2012 Thomas Land 
Publishers, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia (rehabilitation); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; case report; conference paper; diaphragm paralysis; female; human; intermittent positive pressure ventilation; Japan; tracheotomy; ventilated patient; vital capacity; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012218464
PUI
  L364631002
DOI
  10.1310/sci1802-193
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci1802-193
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci1802-193&atitle=Resolution+of+tracheostomy+complications+by+decanulation+and+conversion+to+noninvasive+management+for+a+patient+with+high-level+tetraplegia&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=18&issue=2&spage=193&epage=196&aulast=Toki&aufirst=Akiko&auinit=A.&aufull=Toki+A.&coden=TSIRF&isbn=&pages=193-196&date=2012&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 620
TITLE
  Noninvasive respiratory management of high level spinal cord injury
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu) Department of Physical Medicine and 
Rehabilitation, University Hospital, NY, United States.
(Bach J.R., bachjr@umdnj.edu) Center for Ventilator Management Alternatives, 
University Hospital, NY, United States.
(Bach J.R., bachjr@umdnj.edu) Department of Neurosciences, UMD, New Jersey 
Medical School, Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine and Rehabilitation, University 
Hospital, B-403, 150 Bergen Street, Newark, NJ 07103, United States. Email: 
bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2012-04-03
SOURCE
  Journal of Spinal Cord Medicine (2012) 35:2 (72-80). Date of Publication: 
March 2012
VOLUME
  35
ISSUE
  2
FIRST PAGE
  72
LAST PAGE
  80
DATE OF PUBLICATION
  March 2012
ISSN
  1079-0268
  2045-7723 (electronic)
BOOK PUBLISHER
  Maney Publishing, Suite 1C, Joseph's Well, Hanover Walk, Leeds, United 
Kingdom.
ABSTRACT
  This article describes noninvasive acute and long-term management of the 
respiratory muscle paralysis of high spinal cord injury (SCI). This includes 
full-setting, continuous ventilatory support by noninvasive intermittent 
positive pressure ventilation (NIV) to support inspiratory muscles and 
mechanically assisted coughing (MAC) to support inspiratory and expiratory 
muscles. The NIV and MAC can also be used to extubate or decannulate 
'unweanable' patients with SCI, to prevent intercurrent respiratory tract 
infections from developing into pneumonia and acute respiratory failure 
(ARF), and to eliminate tracheostomy and resort to costly 
electrophrenic/diaphragm pacing (EPP/DP) for most ventilator users, while 
permitting glossopharyngeal breathing (GPB) for security in the event of 
ventilator failure. © The Academy of Spinal Cord Injury Professionals, Inc. 
2012.
EMTREE DRUG INDEX TERMS
  oxygen (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  high level spinal cord injury; mechanically assisted coughing; noninvasive intermittent positive pressure ventilation; positive end expiratory pressure; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure (prevention); breathing; breathing muscle; coughing (therapy); glossopharyngeal breathing; human; hypercapnia; oximetry; oxygen therapy; pathophysiology; pneumonia (prevention); respiratory tract infection (prevention); review; tracheotomy; traumatic brain injury; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012177901
MEDLINE PMID
  22525322 (http://www.ncbi.nlm.nih.gov/pubmed/22525322)
PUI
  L364511985
DOI
  10.1179/2045772311Y.0000000051
FULL TEXT LINK
  http://dx.doi.org/10.1179/2045772311Y.0000000051
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1179%2F2045772311Y.0000000051&atitle=Noninvasive+respiratory+management+of+high+level+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=35&issue=2&spage=72&epage=80&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=JSCMC&isbn=&pages=72-80&date=2012&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 621
TITLE
  Respiratory care of patients with cervical spinal cord injury: a review.
AUTHOR NAMES
  Arora S.; Flower O.; Murray N.P.; Lee B.B.
AUTHOR ADDRESSES
  (Arora S.) Prince of Wales Hospital, Sydney, NSW, Australia.
(Flower O.; Murray N.P.; Lee B.B.)
CORRESPONDENCE ADDRESS
  S. Arora, Prince of Wales Hospital, Sydney, NSW, Australia. Email: 
sumesharora1@gmail.com
FULL RECORD ENTRY DATE
  2012-07-25
SOURCE
  Critical care and resuscitation : journal of the Australasian Academy of 
Critical Care Medicine (2012) 14:1 (64-73). Date of Publication: Mar 2012
VOLUME
  14
ISSUE
  1
FIRST PAGE
  64
LAST PAGE
  73
DATE OF PUBLICATION
  Mar 2012
ISSN
  1441-2772
ABSTRACT
  Respiratory complications following cervical spinal cord injury are common 
and are the leading cause of morbidity and mortality after this type of 
injury. Impaired mechanics of ventilation, poor cough, increased secretions 
and bronchospasm predispose to atelectasis, pneumonia and exacerbations of 
respiratory failure. Prolonged mechanical ventilation and tracheostomy are 
often required. This review discusses the relevant pathophysiology, various 
ventilatory strategies and timing of tracheostomy, and examines the evidence 
surrounding physiotherapeutic and pharmacological treatment options.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing disorder (etiology, therapy); spinal cord injury (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; human; review; tracheostomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  22404065 (http://www.ncbi.nlm.nih.gov/pubmed/22404065)
PUI
  L365270869
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14412772&id=doi:&atitle=Respiratory+care+of+patients+with+cervical+spinal+cord+injury%3A+a+review.&stitle=Crit+Care+Resusc&title=Critical+care+and+resuscitation+%3A+journal+of+the+Australasian+Academy+of+Critical+Care+Medicine&volume=14&issue=1&spage=64&epage=73&aulast=Arora&aufirst=Sumesh&auinit=S.&aufull=Arora+S.&coden=&isbn=&pages=64-73&date=2012&auinit1=S&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 622
TITLE
  Anterior approach to cervical spine
AUTHOR NAMES
  Cheung K.M.C.; Mak K.C.; Luk K.D.K.
AUTHOR ADDRESSES
  (Cheung K.M.C., ken-cheung@hku.hk; Mak K.C.; Luk K.D.K.) Department of 
Orthopaedics and Traumatology, University of Hong Kong, Queen Mary Hospital, 
102 Pokfulam Road, Hong Kong, Hong Kong.
CORRESPONDENCE ADDRESS
  K.M.C. Cheung, Department of Orthopaedics and Traumatology, University of 
Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong. 
Email: ken-cheung@hku.hk
AiP/IP ENTRY DATE
  2011-10-27
FULL RECORD ENTRY DATE
  2012-03-16
SOURCE
  Spine (2012) 37:5 (E297-E302). Date of Publication: 1 Mar 2012
VOLUME
  37
ISSUE
  5
DATE OF PUBLICATION
  1 Mar 2012
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Study Design: Review of surgical technique. Objective: To provide accounts 
of the authors' preferred methods for performing anterior cervical surgery 
with personal tips and pearls. Summary of Background Data: Many have 
described the various anterior surgical approaches to the cervical spine, 
and in this review, we hope to describe our preferences, highlighted with 
some tips and pearls. Methods: Various accounts of the transoral, the 
anterolateral (Smith-Robinson), and the split manubrium approaches were 
reviewed and used as the basis of the review. Additional notes with regard 
to the authors' preferences were noted to provide further guidance. The 
descriptions were delineated from the most cephalad to the most caudal. 
Results: The transoral, the anterolateral (Smith-Robinson), and the 
manubriotomy approaches were described. Each account starts with the basic 
preoperative considerations, then describes the incision and the main 
anatomical landmarks, and finally concludes with closure and main 
complications to monitor for. A brief description of the main pathologies 
that each approach may address is also provided. Conclusion: The 3 anterior 
approaches to the cervical spine are direct and elegant solutions to 
pathologies arising from the anterior column. They supplement the more 
commonly used posterior approaches, which provide stronger multilevel 
fixation, and thus provide an essential tool in the armamentarium of spine 
surgeons. Copyright © 2012 Lippincott Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical surgery; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  anterolateral surgery; aspiration; bone graft; cervical spine; decompression; endotracheal intubation; endotracheal tube; human; iliac crest; incision; liquorrhea (complication); manubriotomy; nasotracheal intubation; osteotomy; postoperative care; postoperative complication (complication); postoperative infection (complication); priority journal; radiography; retropharyngeal abscess (complication); review; skin incision; sternum; surgeon; surgical approach; tongue swelling (complication); tracheostomy; transoral surgery; wound infection (drug therapy, prevention); X ray; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012133532
MEDLINE PMID
  22020587 (http://www.ncbi.nlm.nih.gov/pubmed/22020587)
PUI
  L51682296
DOI
  10.1097/BRS.0b013e318239ccd8
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e318239ccd8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e318239ccd8&atitle=Anterior+approach+to+cervical+spine&stitle=Spine&title=Spine&volume=37&issue=5&spage=&epage=&aulast=Cheung&aufirst=Kenneth+M.C.&auinit=K.M.C.&aufull=Cheung+K.M.C.&coden=SPIND&isbn=&pages=-&date=2012&auinit1=K&auinitm=M.C.
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 623
TITLE
  A dance of empowerment - lessons for the NHI?
AUTHOR NAMES
  Bateman C.
AUTHOR ADDRESSES
  (Bateman C., chrisb@hmpg.co.za)
CORRESPONDENCE ADDRESS
  C. Bateman, Email: chrisb@hmpg.co.za
AiP/IP ENTRY DATE
  2012-02-13
FULL RECORD ENTRY DATE
  2012-02-22
SOURCE
  South African Medical Journal (2012) 102:2 (62-66). Date of Publication: 
2012
VOLUME
  102
ISSUE
  2
FIRST PAGE
  62
LAST PAGE
  66
DATE OF PUBLICATION
  2012
ISSN
  0256-9574
BOOK PUBLISHER
  South African Medical Association, Private Bag X1, Pinelands, South Africa.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  home care; hospital care; patient care; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; child hospitalization; dancing; human; kyphoscoliosis (surgery); lung ventilation; musculoskeletal disease; outpatient; pediatric nurse practitioner; primary health care; spinal cord injury; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2012075253
MEDLINE PMID
  22310446 (http://www.ncbi.nlm.nih.gov/pubmed/22310446)
PUI
  L364197242
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02569574&id=doi:&atitle=A+dance+of+empowerment+-+lessons+for+the+NHI%3F&stitle=S.+Afr.+Med.+J.&title=South+African+Medical+Journal&volume=102&issue=2&spage=62&epage=66&aulast=Bateman&aufirst=Chris&auinit=C.&aufull=Bateman+C.&coden=SAMJA&isbn=&pages=62-66&date=2012&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 624
TITLE
  Are urological procedures in tetraplegic patients safely performed without 
anesthesia? A report of three cases
AUTHOR NAMES
  Vaidyanathan S.; Soni B.; Selmi F.; Singh G.; Esanu C.; Hughes P.; Oo T.; Pulya K.
AUTHOR ADDRESSES
  (Vaidyanathan S., subramanian.vaidyanathan@nhs.net; Soni B., 
bakul.soni@nhs.net; Selmi F., fahed.selmi@nhs.net; Esanu C., 
cristian.esanu@nhs.net; Oo T., tunoo@nhs.net) Regional Spinal Injuries 
Centre, Southport and Formby District General Hospital, Town Lane, Southport 
PR8 6PN, United Kingdom.
(Singh G., gurpreet.singh@nhs.net) Department of Urology, Southport and 
Formby District General Hospital, Town Lane, Southport PR8 6PN, United 
Kingdom.
(Hughes P., peterhughes1@nhs.net) Department of Radiology, Southport and 
Formby District General Hospital, Town Lane, Southport PR8 6PN, United 
Kingdom.
(Pulya K., kamesh.pulya@nhs.net) Department of Cardiology, Southport and 
Formby District General Hospital, Town lane, Southport PR8 6PN, United 
Kingdom.
CORRESPONDENCE ADDRESS
  S. Vaidyanathan, Regional Spinal Injuries Centre, Southport and Formby 
District General Hospital, Town Lane, Southport PR8 6PN, United Kingdom. 
Email: subramanian.vaidyanathan@nhs.net
AiP/IP ENTRY DATE
  2012-03-15
FULL RECORD ENTRY DATE
  2012-03-22
SOURCE
  Patient Safety in Surgery (2012) 6:1 Article Number: 3. Date of Publication: 
20 Feb 2012
VOLUME
  6
ISSUE
  1
DATE OF PUBLICATION
  20 Feb 2012
ISSN
  1754-9493 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., Floor 6, 236 Gray's Inn Road, London, United Kingdom.
ABSTRACT
  Background: Some tetraplegic patients may wish to undergo urological 
procedures without anaesthesia, but these patients can develop autonomic 
dysreflexia if cystoscopy and vesical lithotripsy are performed without 
anaesthesia.Case presentation: We describe three tetraplegic patients, who 
developed autonomic dysreflexia when cystoscopy and laser lithotripsy were 
carried out without anesthesia.In two patients, who declined anaesthesia, 
blood pressure increased to more than 200/110 mmHg during cystoscopy. One of 
these patients developed severe bleeding from bladder mucosa and lithotripsy 
was abandoned. Laser lithotripsy was carried out under subarachnoid block a 
week later in this patient, and this patient did not develop autonomic 
dysreflexia.The third patient with C-3 tetraplegia had undergone correction 
of kyphoscoliotic deformity of spine with spinal rods and pedicular screws 
from the level of T-2 to S-2. Pulmonary function test revealed moderate to 
severe restricted curve. This patient developed vesical calculus and did not 
wish to have general anaesthesia because of possible need for respiratory 
support post-operatively. Subarachnoid block was not considered in view of 
previous spinal fixation. When cystoscopy and laser lithotripsy were carried 
out under sedation, blood pressure increased from 110/50 mmHg to 160/80 
mmHg.Conclusion: These cases show that tetraplegic patients are likely to 
develop autonomic dysreflexia during cystoscopy and vesical lithotripsy, 
performed without anaesthesia. Health professionals should educate spinal 
cord injury patients regarding risks of autonomic dysreflexia, when 
urological procedures are carried out without anaesthesia. If spinal cord 
injury patients are made aware of potentially life-threatening complications 
of autonomic dysreflexia, they are less likely to decline anaesthesia for 
urological procedures. Subrachnoid block or epidural meperidine blocks 
nociceptive impulses from urinary bladder and prevents occurrence of 
autonomic dysreflexia. If spinal cord injury patients with lesions above T-6 
decline anaesthesia, nifedipine 10 mg should be given sublingually prior to 
cystoscopy to prevent increase in blood pressure due to autonomic 
dysreflexia. © 2012 Vaidyanathan et al; licensee BioMed Central Ltd.
EMTREE DRUG INDEX TERMS
  labetalol (drug dose, drug therapy, intravenous drug administration); risedronic acid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  patient safety; quadriplegia (surgery, therapy); urological procedure; 
EMTREE MEDICAL INDEX TERMS
  adult; article; assisted ventilation; autonomic dysreflexia (complication); bladder stone (complication); blood pressure measurement; bone density; bone graft; bone scintiscanning; case report; child; cystoscopy; discectomy; dose response; female; forced vital capacity; human; hypertension (drug therapy); intervertebral disk hernia; kyphoscoliosis (drug therapy, surgery); laser lithotripsy; lung function test; male; mucosal bleeding (complication); open reduction (procedure); peak expiratory flow; pedicle screw; plate fixation; repeated drug dose; school child; spinal anesthesia; spinal cord compression; tracheostomy; 
CAS REGISTRY NUMBERS
  labetalol (32780-64-6, 36894-69-6)
  risedronic acid (105462-24-6, 122458-82-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
  Urology and Nephrology (28)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012140069
PUI
  L364395948
DOI
  10.1186/1754-9493-6-3
FULL TEXT LINK
  http://dx.doi.org/10.1186/1754-9493-6-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17549493&id=doi:10.1186%2F1754-9493-6-3&atitle=Are+urological+procedures+in+tetraplegic+patients+safely+performed+without+anesthesia%3F+A+report+of+three+cases&stitle=Patient+Saf.+Surg.&title=Patient+Safety+in+Surgery&volume=6&issue=1&spage=&epage=&aulast=Vaidyanathan&aufirst=Subramanian&auinit=S.&aufull=Vaidyanathan+S.&coden=&isbn=&pages=-&date=2012&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 625
TITLE
  Unusual case of relapsing and remitting rash with progressive motor sensory 
neuropathy and spinal cord atrophy
AUTHOR NAMES
  Blackburn J.S.; Kuntz N.L.; Grimason M.; Wainwright M.S.
AUTHOR ADDRESSES
  (Blackburn J.S., jblackburn@childrensmemorial.org; Kuntz N.L.; Grimason M.; 
Wainwright M.S.) Department of Pediatrics, Northwestern University, 
Children's Memorial Hospital, Chicago, IL, United States.
CORRESPONDENCE ADDRESS
  J.S. Blackburn, Division of Neurology, No. 51, Children's Memorial Hospital, 
2300 Children's Plaza, Chicago, IL 60614, United States. Email: 
jblackburn@childrensmemorial.org
AiP/IP ENTRY DATE
  2012-03-02
FULL RECORD ENTRY DATE
  2012-03-06
SOURCE
  Journal of Child Neurology (2012) 27:2 (225-228). Date of Publication: 
February 2012
VOLUME
  27
ISSUE
  2
FIRST PAGE
  225
LAST PAGE
  228
DATE OF PUBLICATION
  February 2012
ISSN
  0883-0738
  1708-8283 (electronic)
BOOK PUBLISHER
  SAGE Publications Inc., 2455 Teller Road, Thousand Oaks, United States.
ABSTRACT
  The authors report a case of a 7-year-old girl with a progressive 
sensorimotor peripheral neuropathy with acute relapses associated with a 
desquamating purpuric rash, alopecia, and spinal cord atrophy. Distinctive 
features include systemic involvement with alopecia and rash, peripheral 
nervous system involvement with relapsing and remitting sensorimotor 
neuropathy, and central nervous system involvement with episodes of dystonic 
posturing and spinal cord atrophy. Extensive diagnostic evaluation for known 
causes of skin manifestations associated with peripheral neuropathy has 
failed to identify a cause for this patient's condition. The authors discuss 
the case as an approach to the differential diagnosis and to highlight 
unusual features of this yet to be identified clinical entity. © SAGE 
Publications 2012.
EMTREE DRUG INDEX TERMS
  immunoglobulin (drug therapy, intravenous drug administration); steroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  sensorimotor neuropathy (drug therapy, diagnosis, drug therapy, therapy); spinal cord atrophy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  alopecia; aminoaciduria; areflexia; article; artificial ventilation; auditory evoked potential; bulbar paralysis; case report; child; disease course; dystonia; electromyography; erythrocyte sedimentation rate; evoked response; female; hearing impairment; Hoffmann reflex; human; human tissue; limb weakness; motor nerve conduction; motor unit potential; muscle biopsy; nerve biopsy; pain; plasmapheresis; polyneuropathy; priority journal; proprioception; purpuric rash; quadriplegia (complication); relapse; respiratory failure (complication, surgery, therapy); school child; sensory dysfunction; temperature sense; touch; tracheostomy; vaginal delivery; vibration sense; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012113423
MEDLINE PMID
  21940692 (http://www.ncbi.nlm.nih.gov/pubmed/21940692)
PUI
  L364316422
DOI
  10.1177/0883073811417872
FULL TEXT LINK
  http://dx.doi.org/10.1177/0883073811417872
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08830738&id=doi:10.1177%2F0883073811417872&atitle=Unusual+case+of+relapsing+and+remitting+rash+with+progressive+motor+sensory+neuropathy+and+spinal+cord+atrophy&stitle=J.+Child+Neurol.&title=Journal+of+Child+Neurology&volume=27&issue=2&spage=225&epage=228&aulast=Blackburn&aufirst=Joanna+S.&auinit=J.S.&aufull=Blackburn+J.S.&coden=JOCNE&isbn=&pages=225-228&date=2012&auinit1=J&auinitm=S
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 626
TITLE
  A significant cervical spine fracture: Think of the airway
AUTHOR NAMES
  Cleiman P.; Nemeth J.; Vetere P.
AUTHOR ADDRESSES
  (Cleiman P.) Faculty of Medicine, McGill University, Montreal, QC, Canada.
(Nemeth J.; Vetere P.) Department of Emergency Medicine, Montreal General 
Hospital, McGill University Health Centre, 1650 Cedar Avenue, Montreal, QC 
H3G 1A4, Canada.
CORRESPONDENCE ADDRESS
  J. Nemeth, Department of Emergency Medicine, Montreal General Hospital, 
McGill University Health Centre, 1650 Cedar Avenue, Montreal, QC H3G 1A4, 
Canada.
AiP/IP ENTRY DATE
  2012-02-22
FULL RECORD ENTRY DATE
  2012-02-27
SOURCE
  Journal of Emergency Medicine (2012) 42:2 (e23-e25). Date of Publication: 
February 2012
VOLUME
  42
ISSUE
  2
DATE OF PUBLICATION
  February 2012
ISSN
  0736-4679
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background: Airway compromise is a potential complication of significant 
cervical spine injury. Objectives: To alert emergency physicians to be aware 
of possible airway collapse after serious cervical spine injury. Case 
Report: We report a case of an 87-year-old man who presented to the 
emergency department with an unstable cervical spine fracture after a fall. 
He subsequently developed complete upper airway obstruction from 
prevertebral soft tissue swelling, requiring a cricothyrotomy after a failed 
intubation attempt. Conclusion: Patients with significant blunt cervical 
spine trauma can be at high risk for upper airway compromise. © 2012 
Elsevier Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture; upper respiratory tract obstruction (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  aged; ankylosing spondylitis; article; case report; emergency physician; emergency ward; face injury; human; male; priority journal; tracheotomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012092446
MEDLINE PMID
  19128920 (http://www.ncbi.nlm.nih.gov/pubmed/19128920)
PUI
  L50380870
DOI
  10.1016/j.jemermed.2008.07.027
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jemermed.2008.07.027
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07364679&id=doi:10.1016%2Fj.jemermed.2008.07.027&atitle=A+significant+cervical+spine+fracture%3A+Think+of+the+airway&stitle=J.+Emerg.+Med.&title=Journal+of+Emergency+Medicine&volume=42&issue=2&spage=&epage=&aulast=Cleiman&aufirst=Paula&auinit=P.&aufull=Cleiman+P.&coden=JEMMD&isbn=&pages=-&date=2012&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 627
TITLE
  Do personal preferences for life-sustaining therapy influence medical 
decision making among pediatric intensivists?
AUTHOR NAMES
  Needle J.; Mularski R.; Nguyen T.; Fromme E.
AUTHOR ADDRESSES
  (Needle J.; Nguyen T.; Fromme E.) Oregon Health and Science University, 
Portland, United States.
(Mularski R.) Kaiser Permanente, Portland, United States.
CORRESPONDENCE ADDRESS
  J. Needle, Oregon Health and Science University, Portland, United States.
FULL RECORD ENTRY DATE
  2012-01-28
SOURCE
  Journal of Pain and Symptom Management (2012) 43:2 (342). Date of 
Publication: February 2012
VOLUME
  43
ISSUE
  2
FIRST PAGE
  342
DATE OF PUBLICATION
  February 2012
CONFERENCE NAME
  Annual Assembly of the American Academy of Hospice and Palliative Medicine 
and the Hospice and Palliative Nurses Association 2012
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2012-03-07 to 2012-03-10
ISSN
  0885-3924
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Objectives 1. Measure the personal preferences for lifesustaining treatment 
among pediatric intensivists. 2. Examine the relationship between pediatric 
intensivists' personal preferences for life-sustaining treatment and medical 
decision making. Background. Withholding and withdrawal of lifesustaining 
treatments in the pediatric intensive care unit is influenced by physician 
characteristics. Research objectives. To examine the relationship between 
pediatric intensivists' personal preferences for life-sustaining therapies 
and medical decision making. Method. Cross-sectional national anonymous mail 
survey of pediatric intensivists identified by the American Medical 
Association Masterfile. A Personal Preference Score (PPS) was calculated 
from responses to questions of personal preferences for life-sustaining 
treatments adapted from “Your Life, Your Choices,” by Pearlman and 
colleagues. Physicians were asked to consider the “acceptability” of 
treatment options in a hypothetical scenario of a child with a spinal cord 
transection. Logistic regression controlling for socio-demographic 
characteristics computed odds ratios that represent the association between 
finding an option “acceptable” to a one standard deviation decrease in the 
PPS (lower preference for life-sustaining therapy). Result. A total of 471 
(30%) surveys were returned. Intensivists with lower PPS were significantly 
less likely to consider it acceptable to offer (OR = 0.64; 95% CI, 
0.62-0.66; p≤ 0.01) and recommend (OR = 0.73; 95% CI, 0.71- 0.74; p≤ 0.01) 
performing a tracheostomy, less likely to offer (OR = 0.34; 95% CI, 
0.28-0.34; p = 0.02) and recommend (OR = 0.53; 95% CI, 0.52-0.55; p≤ 0.01) 
reintubation if the patient failed extubation, and were more likely to 
consider it acceptable to offer (OR = 1.58; 95% CI, 1.55-1.62; p≤ 0.01) and 
recommend (OR = 1.42; 95% CI, 1.39-1.46; p≤ 0.01) that the patient not be 
reintubated if extubation failed and to recommend DNR status (OR 1.34; 95% 
CI, 1.31-1.37; p = <0.01). Conclusion. Personal preferences for 
life-sustaining therapy were significantly associated with scenario-based 
responses to acceptability of withholding/withdrawal of life-sustaining 
therapies. Implications for research, policy, or practice. Physicians should 
ensure that family preferences are elicited and incorporated into medical 
decision making.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hospice; human; life sustaining treatment; medical decision making; nurse; palliative therapy; 
EMTREE MEDICAL INDEX TERMS
  child; demography; extubation; intensive care unit; logistic regression analysis; medical society; patient; physician; policy; risk; spinal cord transsection; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70647426
DOI
  10.1016/j.jpainsymman.2011.12.049
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jpainsymman.2011.12.049
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08853924&id=doi:10.1016%2Fj.jpainsymman.2011.12.049&atitle=Do+personal+preferences+for+life-sustaining+therapy+influence+medical+decision+making+among+pediatric+intensivists%3F&stitle=J.+Pain+Symptom+Manage.&title=Journal+of+Pain+and+Symptom+Management&volume=43&issue=2&spage=342&epage=&aulast=Needle&aufirst=Jennifer&auinit=J.&aufull=Needle+J.&coden=&isbn=&pages=342-&date=2012&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 628
TITLE
  Double trouble: Spinal muscular atrophy type II and seropositive myasthenia 
gravis in the same patient
AUTHOR NAMES
  Jokela M.; Udd B.; Päivärinta M.
AUTHOR ADDRESSES
  (Jokela M., mejoke@utu.fi; Päivärinta M.) Department of Neurology, Turku 
University Central Hospital, Turku, Finland.
(Udd B.) Neuromuscular Center, Tampere University Central Hospital, Tampere, 
Finland.
(Udd B.) Vasa Central Hospital, Vasa, Finland.
CORRESPONDENCE ADDRESS
  M. Jokela, Turku University Central Hospital, Department of Neurology, P.O. 
Box 51, 20521 Turku, Finland. Email: mejoke@utu.fi
AiP/IP ENTRY DATE
  2011-08-24
FULL RECORD ENTRY DATE
  2012-02-13
SOURCE
  Neuromuscular Disorders (2012) 22:2 (129-130). Date of Publication: February 
2012
VOLUME
  22
ISSUE
  2
FIRST PAGE
  129
LAST PAGE
  130
DATE OF PUBLICATION
  February 2012
ISSN
  0960-8966
  1873-2364 (electronic)
BOOK PUBLISHER
  Elsevier Ltd, Langford Lane, Kidlington, Oxford, United Kingdom.
ABSTRACT
  Autosomal recessive proximal spinal muscular atrophy is caused by deletions 
in the survival of motor neuron (SMN1) gene, while autoimmune myasthenia 
gravis is an acquired disorder. An association between these two diseases 
has not been reported. Our patient with intermediate spinal muscular atrophy 
(SMA type II) did not need alimentary or respiratory aid until age 51 when 
he suddenly developed bulbar weakness and respiratory insufficiency. 
Seropositive myasthenia gravis was confirmed and the corresponding symptoms 
resolved on treatment. © 2011 Elsevier B.V.
EMTREE DRUG INDEX TERMS
  azathioprine (drug combination); cholinergic receptor antibody (endogenous compound); immunoglobulin (drug combination, intravenous drug administration); prednisone (drug combination, oral drug administration); pyridostigmine (drug combination); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myasthenia gravis; spinal muscular atrophy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; article; bulbar paralysis; case report; deterioration; drug dose reduction; dysphagia; electromyogram; face muscle; feeding tube; gene; gene deletion; genetic screening; homozygote; human; lip reading; male; masticatory muscle; motor unit potential; muscle weakness; ophthalmoplegia; priority journal; ptosis (eyelid); respiratory tract infection; scoliosis; SMN1 gene; tracheostomy; 
CAS REGISTRY NUMBERS
  azathioprine (446-86-6)
  immunoglobulin (9007-83-4)
  prednisone (53-03-2)
  pyridostigmine (101-26-8, 155-97-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012062309
MEDLINE PMID
  21862330 (http://www.ncbi.nlm.nih.gov/pubmed/21862330)
PUI
  L51582315
DOI
  10.1016/j.nmd.2011.07.011
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nmd.2011.07.011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09608966&id=doi:10.1016%2Fj.nmd.2011.07.011&atitle=Double+trouble%3A+Spinal+muscular+atrophy+type+II+and+seropositive+myasthenia+gravis+in+the+same+patient&stitle=Neuromuscular+Disord.&title=Neuromuscular+Disorders&volume=22&issue=2&spage=129&epage=130&aulast=Jokela&aufirst=Manu&auinit=M.&aufull=Jokela+M.&coden=NEDIE&isbn=&pages=129-130&date=2012&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 629
TITLE
  Pulmonary rehabilitation using modified threshold inspiratory muscle trainer 
(IMT) in patients with tetraplegia
AUTHOR NAMES
  Yasar F.; Tasci C.; Savci S.; Tozkoparan E.; Deniz O.; Balkan A.; Bilgic H.
AUTHOR ADDRESSES
  (Yasar F., fundasyasar@gmail.com; Tasci C., ctasci@gata.edu.tr; Tozkoparan 
E., etozkoparan@gata.edu.tr; Deniz O., odeniz@gata.edu.tr; Balkan A., 
abalkan@gata.edu.tr; Bilgic H., hbilgic@gata.edu.tr) Gulhane Medical School, 
Department of Pulmonary Medicine, Ankara, Turkey.
(Savci S., semasavci@yahoo.com) Department of Pulmonary Rehabilitation, 
Hacettepe University, Ankara, Turkey.
CORRESPONDENCE ADDRESS
  C. Tasci, Gulhane Medical School, Department of Pulmonary Medicine, Ankara, 
Turkey. Email: ctasci@gata.edu.tr
AiP/IP ENTRY DATE
  2012-04-20
FULL RECORD ENTRY DATE
  2012-04-24
SOURCE
  Case Reports in Medicine (2012) 2012 Article Number: 587901. Date of 
Publication: 2012
VOLUME
  2012
DATE OF PUBLICATION
  2012
ISSN
  1687-9635 (electronic)
  1687-9627
BOOK PUBLISHER
  Hindawi Limited
ABSTRACT
  It is aimed to present the usefulness of inspiratory muscle trainer (IMT) in 
treatment of a 20-year-old male patient with diaphragmatic paralysis and 
tetraplegia due to spinal cord injury (SCI), and supporting effect of IMT in 
recovering from respiratory failure by rendering his diaphragm functions. 
The treatment was applied through the tracheostomy cannula by a modified IMT 
device. After applying IMT for three weeks, it was observed that the 
diaphragm recovered its functions in electromyography (EMG) test. As a 
result, in this study, we present a case where a patient could live without 
any respiratory device for the rest of his life with the help of modified 
IMT. © Copyright 2012 Funda Yasar et al.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  devices; pulmonary rehabilitation; quadriplegia (complication); respiratory exerciser; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cannula; case report; diaphragm paralysis (complication, rehabilitation); electromyography; human; male; priority journal; respiratory failure (complication); spinal cord injury; tracheostomy; treatment outcome; 
DEVICE TRADE NAMES
  Threshold Inspiratory Muscle Trainer
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012212208
PUI
  L364616333
DOI
  10.1155/2012/587901
FULL TEXT LINK
  http://dx.doi.org/10.1155/2012/587901
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16879635&id=doi:10.1155%2F2012%2F587901&atitle=Pulmonary+rehabilitation+using+modified+threshold+inspiratory+muscle+trainer+%28IMT%29+in+patients+with+tetraplegia&stitle=Case+Rep.+Med.&title=Case+Reports+in+Medicine&volume=2012&issue=&spage=&epage=&aulast=Yasar&aufirst=Funda&auinit=F.&aufull=Yasar+F.&coden=&isbn=&pages=-&date=2012&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 630
TITLE
  Dysphagia and respiratory care in individuals with tetraplegia: Incidence, 
associated factors, and preventable complications
AUTHOR NAMES
  Shem K.; Castillo K.; Wong S.; Chang J.; Kolakowsky-Hayner S.
AUTHOR ADDRESSES
  (Shem K.) Department of Physical Medicine and Rehabilitation, Santa Clara 
Valley Medical Center, San Jose, CA, United States.
(Castillo K.) Department of Therapy Service, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
(Wong S.) Department of Respiratory Therapy, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
(Chang J.; Kolakowsky-Hayner S.) Rehabilitation Research Center, Santa Clara 
Valley Medical Center, San Jose, CA, United States.
CORRESPONDENCE ADDRESS
  K. Shem, Department of Physical Medicine and Rehabilitation, Santa Clara 
Valley Medical Center, San Jose, CA, United States.
AiP/IP ENTRY DATE
  2012-02-13
FULL RECORD ENTRY DATE
  2012-02-15
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2012) 18:1 (15-22). Date of 
Publication: 1 Jan 2012
VOLUME
  18
ISSUE
  1
FIRST PAGE
  15
LAST PAGE
  22
DATE OF PUBLICATION
  1 Jan 2012
ISSN
  1082-0744
  1945-5763 (electronic)
BOOK PUBLISHER
  Thomas Land Publishers Inc., 255 Jefferson Road, St. Louis, United States.
ABSTRACT
  Dysphagia occurs in a significant number of individuals with spinal cord 
injury (SCI) presenting to acute care and inpatient rehabilitation. This 
prospective study has found dysphagia in nearly 40% of individuals with 
tetraplegia. Tracheostomy, mechanical ventilation, nasogastric tube, and age 
are significant risk factors. The detrimental complications of dysphagia in 
SCI can cause significant morbidity and delays in rehabilitation. Thus, 
early and accurate diagnosis of dysphagia is imperative to reduce the risk 
of developing life-threatening complications. Incidence and risk factors of 
dysphagia and the use of the bedside swallow evaluation (BSE) and 
videofluoroscopy swallow study (VFSS) to diagnose dysphagia are presented. 
The often underappreciated role of respiratory therapists, including assist 
cough, high tidal volume ventilation, and the use of Passy-Muir valve, in 
the care of individuals with SCI who have dysphagia is discussed. Improved 
secretion management and respiratory stabilization enable the individuals 
with dysphagia to be evaluated sooner and safely by a speech pathologist. 
Early evaluation and intervention could improve upon morbidity and delayed 
rehabilitation, thus improving overall clinical outcomes. © 2012 Thomas Land 
Publishers, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (diagnosis); quadriplegia; respiratory care; 
EMTREE MEDICAL INDEX TERMS
  adult; age; aged; article; artificial ventilation; bedside swallow evaluation; clinical article; diagnostic test; female; human; male; nasogastric tube; risk factor; spinal cord injury; tracheostomy; videofluoroscopy swallow study; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012074380
PUI
  L364195251
DOI
  10.1310/sci1801-15
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci1801-15
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci1801-15&atitle=Dysphagia+and+respiratory+care+in+individuals+with+tetraplegia%3A+Incidence%2C+associated+factors%2C+and+preventable+complications&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=18&issue=1&spage=15&epage=22&aulast=Shem&aufirst=Kazuko&auinit=K.&aufull=Shem+K.&coden=TSIRF&isbn=&pages=15-22&date=2012&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 631
TITLE
  Tracheotomy outcomes and complications: A national perspective
AUTHOR NAMES
  Shah R.K.; Lander L.; Berry J.G.; Nussenbaum B.; Merati A.; Roberson D.W.
AUTHOR ADDRESSES
  (Shah R.K., rshah@cnmc.org) Division of Otolaryngology, Children's National 
Medical Center, George Washington University, 111 Michigan Avenue NW, 
Washington, DC 20010, United States.
(Lander L.) Department of Epidemiology, University of Nebraska Medical 
Center, Omaha, NE, United States.
(Berry J.G.) Division of General Pediatrics, Harvard Medical School, 
Children's Hospital Boston, Boston, MA, United States.
(Nussenbaum B.) Department of Otolaryngology-Head and Neck Surgery, School 
of Medicine, Washington University, St. Louis, MO, United States.
(Merati A.) Department of Otolaryngology-Head and Neck Surgery, School of 
Medicine, University of Washington, Seattle, WA, United States.
(Roberson D.W.) Department of Otolaryngology, Harvard Medical School, 
Children's Hospital Boston, Boston, MA, United States.
CORRESPONDENCE ADDRESS
  R.K. Shah, Division of Otolaryngology, Children's National Medical Center, 
George Washington University, 111 Michigan Avenue NW, Washington, DC 20010, 
United States. Email: rshah@cnmc.org
AiP/IP ENTRY DATE
  2011-12-30
FULL RECORD ENTRY DATE
  2012-01-03
SOURCE
  Laryngoscope (2012) 122:1 (25-29). Date of Publication: January 2012
VOLUME
  122
ISSUE
  1
FIRST PAGE
  25
LAST PAGE
  29
DATE OF PUBLICATION
  January 2012
ISSN
  0023-852X
  1531-4995 (electronic)
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Objectives/Hypothesis: To provide national level data on frequency of 
tracheotomy and complication rate and in-hospital mortality following 
tracheotomy. Study Design: Retrospective cohort study. Methods: 
Retrospective cohort study using a public national database, the Nationwide 
Inpatient Sample, 2006. Results: There were 113,653 tracheotomies performed 
in patients 18 years or older in 2006. The overall complication rate was 
3.2%, and the in-hospital mortality rate was 19.2%. The data suggest that 
in-hospital mortality is usually due to the underlying illness rather than 
the tracheotomy. Mortality was higher in patients older than 50 years, those 
with cardiac conditions, particularly congestive heart failure, those with 
public insurance, and patients in Northeast hospitals. Patients with 
neurologic conditions, trauma, and upper airway infection are more likely to 
survive to discharge. In-hospital mortality is slightly higher in 
nonteaching hospitals. Conclusions: This database study determined baseline 
data for the rate of complications (3.2%) for patients undergoing 
tracheotomy; it showed that only 80% of adult patients who underwent 
tracheotomy in the United States survived to discharge. Patients located in 
the Northeast, patients more than 50 years old, and patients with cardiac 
conditions were at particularly high risk for mortality. This study provides 
normative data for these outcomes for patient counseling and planning future 
quality improvement initiatives in this patient population. © 2011 The 
American Laryngological, Rhinological, and Otological Society, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  mortality; postoperative complication (complication); tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; asthma (complication); brain injury (complication); cardiomyopathy (complication); cerebral palsy (complication); cerebrovascular accident (complication); chronic obstructive lung disease (complication); congestive heart failure (complication); dementia (complication); epilepsy (complication); heart infarction (complication); human; major clinical study; muscular dystrophy (complication); myocarditis (complication); obesity (complication); outcome assessment; paralysis (complication); pneumonia (complication); priority journal; review; risk factor; skull fracture (complication); spinal cord injury (complication); upper respiratory tract infection (complication); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011705447
MEDLINE PMID
  22183625 (http://www.ncbi.nlm.nih.gov/pubmed/22183625)
PUI
  L363141235
DOI
  10.1002/lary.21907
FULL TEXT LINK
  http://dx.doi.org/10.1002/lary.21907
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0023852X&id=doi:10.1002%2Flary.21907&atitle=Tracheotomy+outcomes+and+complications%3A+A+national+perspective&stitle=Laryngoscope&title=Laryngoscope&volume=122&issue=1&spage=25&epage=29&aulast=Shah&aufirst=Rahul+K.&auinit=R.K.&aufull=Shah+R.K.&coden=LARYA&isbn=&pages=25-29&date=2012&auinit1=R&auinitm=K
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 632
TITLE
  Inadvertent insertion of nasogastric tube into the brain stem and spinal 
cord after endoscopic skull base surgery
AUTHOR NAMES
  Hanna A.S.; Grindle C.R.; Patel A.A.; Rosen M.R.; Evans J.J.
AUTHOR ADDRESSES
  (Hanna A.S.) Department of Neurological Surgery, University of Wisconsin, 
School of Medicine and Public Health, Madison, WI, United States.
(Grindle C.R.; Rosen M.R.) Department of Otolaryngology-Head and Neck 
Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, United 
States.
(Patel A.A.) Department of Orthopaedic Surgery, University of Utah School of 
Medicine, Salt Lake City, UT, United States.
(Evans J.J., james.evans@jefferson.edu) Department of Neurological Surgery, 
Thomas Jefferson University Hospital, Philadelphia, PA, United States.
CORRESPONDENCE ADDRESS
  J.J. Evans, Department of Neurological Surgery, Thomas Jefferson University 
Hospital, Philadelphia, PA, United States. Email: james.evans@jefferson.edu
AiP/IP ENTRY DATE
  2011-06-29
FULL RECORD ENTRY DATE
  2012-03-29
SOURCE
  American Journal of Otolaryngology - Head and Neck Medicine and Surgery 
(2012) 33:1 (178-180). Date of Publication: January-February 2012
VOLUME
  33
ISSUE
  1
FIRST PAGE
  178
LAST PAGE
  180
DATE OF PUBLICATION
  January-February 2012
ISSN
  0196-0709
  1532-818X (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  A significant number of neurosurgical patients require feeding tube 
placement via a nasogastric route. It is used as a temporary access for 
enteral feeding until patients are able to swallow or receive permanent 
access. Despite how commonly feeding tubes are used, they are not without 
potential complications. We report a case of inadvertent placement of 
small-bore feeding tube into the brain stem and spinal cord in a patient 
with a history of previous endoscopic transnasal resection of clival 
chordoma. We discuss the management of this complication and the strategies 
that have been developed to avoid this complication in the future. © 2012 
Elsevier Inc. All rights reserved.
EMTREE DRUG INDEX TERMS
  fibrin glue; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chordoma (diagnosis, radiotherapy, surgery); clival chordoma (diagnosis, radiotherapy, surgery); craniotomy; endoscopic surgery; nasogastric tube; 
EMTREE MEDICAL INDEX TERMS
  abdominal radiography; adult; article; brain decompression; brain stem; cancer radiotherapy; case report; cerebrospinal fluid otorrhea; computer assisted tomography; esophagogastrostomy; gait disorder; gastrostomy; headache; hemostasis; human; hyperlipidemia; hypertension; interstitial pneumonia (complication); male; meningitis; nuclear magnetic resonance imaging; obesity; ophthalmoplegia; osteoarthritis; pneumonia (complication); priority journal; quadriplegia; sepsis; sleep disordered breathing; spinal cord; spinal cord disease; surgical risk; thoracotomy; tracheostomy; wedge resection; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012169683
MEDLINE PMID
  21715048 (http://www.ncbi.nlm.nih.gov/pubmed/21715048)
PUI
  L51495300
DOI
  10.1016/j.amjoto.2011.04.001
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.amjoto.2011.04.001
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01960709&id=doi:10.1016%2Fj.amjoto.2011.04.001&atitle=Inadvertent+insertion+of+nasogastric+tube+into+the+brain+stem+and+spinal+cord+after+endoscopic+skull+base+surgery&stitle=Am.+J.+Otolaryngol.+Head+Neck+Med.+Surg.&title=American+Journal+of+Otolaryngology+-+Head+and+Neck+Medicine+and+Surgery&volume=33&issue=1&spage=178&epage=180&aulast=Hanna&aufirst=Amgad+S.&auinit=A.S.&aufull=Hanna+A.S.&coden=AJOTD&isbn=&pages=178-180&date=2012&auinit1=A&auinitm=S
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 633
TITLE
  Prone positioning: Is it safe and effective?
AUTHOR NAMES
  Dirkes S.; Dickinson S.; Havey R.; O'Brien D.
AUTHOR ADDRESSES
  (Dirkes S.) Surgical Intensive Care and Progressive Care, United States.
(Dickinson S., sdickins@umich.edu) Surgical Intensive Care/Rapid Response, 
University of Michigan, University of Michigan Hospital and Heath Centers, 
1500 E Medical Center Dr, Ann Arbor, MI 48176, United States.
(Havey R.) Surgical Intensive Care, University of Michigan, United States.
(Dickinson S., sdickins@umich.edu; O'Brien D.) University of Michigan, 
School of Nursing, United States.
(O'Brien D.) University of Michigan Hospitals, Health Centers, Ann Arbor, 
MI, United States.
CORRESPONDENCE ADDRESS
  S. Dickinson, Surgical Intensive Care/Rapid Response, University of 
Michigan, University of Michigan Hospital and Heath Centers, 1500 E Medical 
Center Dr, Ann Arbor, MI 48176, United States. Email: sdickins@umich.edu
AiP/IP ENTRY DATE
  2011-12-23
FULL RECORD ENTRY DATE
  2011-12-27
SOURCE
  Critical Care Nursing Quarterly (2012) 35:1 (64-75). Date of Publication: 
January-March 2012
VOLUME
  35
ISSUE
  1
FIRST PAGE
  64
LAST PAGE
  75
DATE OF PUBLICATION
  January-March 2012
ISSN
  0887-9303
  1550-5111 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Prone positioning has been used as a treatment option for patients with 
acute lung injury or acute respiratory distress syndrome (ARDS) since the 
early 1970s. Prone position and extended prone position ventilation have 
been shown to increase end-expiratory lung volume, alveolar recruitment, and 
oxygenation in patients with severe hypoxemic and acute respiratory failure. 
Prone positioning is not a benign procedure, and there are potential risks 
(complications) that can occur to both the patient and the health care 
worker. Notable complications that can arise include: unplanned extubation, 
lines pulled, tubes kinked, and back and other injuries to personnel. Prone 
positioning is a viable, inexpensive therapy for the treatment of severe 
ARDS. This maneuver consistently improves systemic oxygenation in 70% to 80% 
of patients with ARDS. With the utilization of a standardized protocol and a 
trained and dedicated critical care staff, prone positioning can be 
performed safely. Copyright © 2012 Wolters Kluwer Health | Lippincott 
Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult respiratory distress syndrome; body position; 
EMTREE MEDICAL INDEX TERMS
  abdominal surgery; aortic balloon; article; asthma; bleeding; cardiopulmonary arrest; clinical effectiveness; decubitus (complication); device removal; extubation; face edema (complication); fracture fixation; head injury; heart arrhythmia (complication); human; hypotension (complication); intensive care; intracranial pressure; intraocular pressure; kyphoscoliosis; lung hemodynamics; mean arterial pressure; multiple trauma; osteoarthritis; oxygenation; pelvis fracture; pregnancy; rheumatoid arthritis; rib fracture; safety; seizure; spinal cord injury; systolic blood pressure; thorax surgery; trachea obstruction (complication); tracheostomy; traction therapy; treatment contraindication; vomiting (complication); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011693010
MEDLINE PMID
  22157493 (http://www.ncbi.nlm.nih.gov/pubmed/22157493)
PUI
  L363102681
DOI
  10.1097/CNQ.0b013e31823b20c6
FULL TEXT LINK
  http://dx.doi.org/10.1097/CNQ.0b013e31823b20c6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08879303&id=doi:10.1097%2FCNQ.0b013e31823b20c6&atitle=Prone+positioning%3A+Is+it+safe+and+effective%3F&stitle=Crit.+Care+Nurs.+Q.&title=Critical+Care+Nursing+Quarterly&volume=35&issue=1&spage=64&epage=75&aulast=Dirkes&aufirst=Susan&auinit=S.&aufull=Dirkes+S.&coden=CCNQE&isbn=&pages=64-75&date=2012&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 634
TITLE
  Factors associated with early mortality after cervical spinal cord injury
AUTHOR NAMES
  Shao J.; Zhu W.; Chen X.; Jia L.; Song D.; Zhou X.; Yan W.; Zhang Y.
AUTHOR ADDRESSES
  (Shao J.; Zhu W.; Chen X., chenxiongsheng@vip.sohu.com; Jia L.; Song D.; 
Zhou X.; Yan W.; Zhang Y.) Department of Orthopaedics, Shanghai Changzheng 
Hospital, #415 Feng Yang Road, Shanghai 200003, China.
CORRESPONDENCE ADDRESS
  X. Chen, Department of Orthopaedics, Shanghai Changzheng Hospital, #415 Feng 
Yang Road, Shanghai 200003, China. Email: chenxiongsheng@vip.sohu.com
AiP/IP ENTRY DATE
  2011-12-30
FULL RECORD ENTRY DATE
  2012-01-03
SOURCE
  Journal of Spinal Cord Medicine (2011) 34:6 (555-562). Date of Publication: 
2011
VOLUME
  34
ISSUE
  6
FIRST PAGE
  555
LAST PAGE
  562
DATE OF PUBLICATION
  2011
ISSN
  1079-0268
  2045-7723 (electronic)
BOOK PUBLISHER
  Maney Publishing, Suite 1C, Joseph's Well, Hanover Walk, Leeds, United 
Kingdom.
ABSTRACT
  Background: A relatively high early mortality rate (<30 days post-injury) 
for cervical spinal cord injury (SCI) has been observed. Objective: To 
investigate this early mortality rate observed after cervical SCI and 
analyze the associated influential factors. Methods: Medical records for 
1163 patients with cervical SCI were reviewed, and the number of patients 
with early mortality was documented. Through logistic regression analysis, 
the effects of age, gender, occupation, cause of injury, severity of injury, 
highest involved spinal cord segment, nutritional condition during 
hospitalization, surgical treatment, tracheotomy, etc., on early mortality 
were assessed. Implementation of early treatment (i.e. surgery, tracheotomy, 
and nutritional support) and its effect on patient prognosis were also 
analyzed. Results: Early mortality occurred in 109 of 1163 patients (9.4%). 
Four factors affected the early mortality rate, including level and severity 
of SCI, whether or not surgery was performed, the time interval between SCI 
and surgery, malnutrition, and tracheotomy. Patients with an American Spinal 
Injury Association grade of A, a high cervical SCI (C1-C3), and/or no 
surgical intervention were statistically more likely to have early mortality 
(P < 0.001). Conclusion: Severe cervical SCI, upper-level cervical cord 
injury, malnutrition, and inappropriate tracheotomy are risk factors for 
early mortality in patients with cervical SCI. Surgery can reduce early 
mortality. Early tracheotomy should be performed in patients with complete 
upper-level cervical SCI, but patients with incomplete cervical SCI or 
complete low-level cervical SCI should initially be treated surgically to 
maintain smooth airway flow. © The Academy of Spinal Cord Injury 
Professionals, Inc. 2011.
EMTREE DRUG INDEX TERMS
  albumin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; age; aged; albumin blood level; article; controlled study; early intervention; falling; female; gender; human; injury severity; major clinical study; male; malnutrition; medical record review; mortality; nutritional assessment; nutritional status; nutritional support; occupation; prognosis; spine surgery; survival time; tracheotomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011706199
MEDLINE PMID
  22330110 (http://www.ncbi.nlm.nih.gov/pubmed/22330110)
PUI
  L363143293
DOI
  10.1179/2045772311Y.0000000024
FULL TEXT LINK
  http://dx.doi.org/10.1179/2045772311Y.0000000024
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1179%2F2045772311Y.0000000024&atitle=Factors+associated+with+early+mortality+after+cervical+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=34&issue=6&spage=555&epage=562&aulast=Shao&aufirst=Jiang&auinit=J.&aufull=Shao+J.&coden=JSCMC&isbn=&pages=555-562&date=2011&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 635
TITLE
  Malignant hyperpyrexia in cervical spine injury
AUTHOR NAMES
  Arumugam S.K.; Balakrishnan S.; Parchani A.
AUTHOR ADDRESSES
  (Arumugam S.K., aarumugam@hmc.org.qa; Parchani A.) Trauma Surgery Section, 
Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
(Balakrishnan S.) Department of Anesthesia, Hamad Medical Corporation, Doha, 
Qatar.
CORRESPONDENCE ADDRESS
  S.K. Arumugam, Trauma Surgery Section, Department of Surgery, Hamad Medical 
Corporation, Doha, Qatar. Email: aarumugam@hmc.org.qa
AiP/IP ENTRY DATE
  2013-01-02
FULL RECORD ENTRY DATE
  2013-01-10
SOURCE
  Qatar Medical Journal (2011) 20:2 (62-63). Date of Publication: December 
2011
VOLUME
  20
ISSUE
  2
FIRST PAGE
  62
LAST PAGE
  63
DATE OF PUBLICATION
  December 2011
ISSN
  0253-8253
BOOK PUBLISHER
  Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
ABSTRACT
  Pyrexia is an elevation of body temperature above the normal range due to an 
increase in the hypothalamic thermoregulatory set point. Hyperpyrexia is an 
extreme elevation of body temperature equal to or greater than 41.5°C 
(106.7°F).((1)) Malignant hyperpyrexia is a rare and idiopathic extreme 
elevation of core body temperature above 42°C characterized by the acute 
onset of hyperthermia, coagulopathy and shock.((2)) It is potentially 
life-threatening and can rapidly progress to severe liver and renal 
impairment, acidosis and encephalopathy. Reported here is a case of 
malignant hyperpyrexia in a patient with injury of the cervical spine.
EMTREE DRUG INDEX TERMS
  analgesic agent; D dimer (endogenous compound); fluconazole; heart enzyme (endogenous compound); infusion fluid; kidney enzyme (endogenous compound); liver enzyme (endogenous compound); meropenem; methylprednisolone; myoglobin (endogenous compound); piperacillin plus tazobactam (intravenous drug administration); vancomycin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; malignant hyperthermia; 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (therapy); adult; article; atelectasis; body temperature; brain edema; bronchoscopy; case report; chest tube; clinical article; comminuted fracture; computer assisted tomography; deep vein thrombosis (prevention); electroencephalography; falling; Glasgow coma scale; gray matter; headache; hematoma; hematothorax; hemodialysis; hepatitis; hospital admission; human; hypotension; immobilization; intensive care; intubation; limb weakness; long term care; male; neck pain; nuclear magnetic resonance imaging; paraplegia; patient transport; physical examination; prophylaxis; rhabdomyolysis; rib fracture; spirometry; sputum examination; Staphylococcus aureus; thorax radiography; tracheostomy; white matter; 
CAS REGISTRY NUMBERS
  fluconazole (86386-73-4)
  meropenem (96036-03-2)
  methylprednisolone (6923-42-8, 83-43-2)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012749534
PUI
  L366322240
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02538253&id=doi:&atitle=Malignant+hyperpyrexia+in+cervical+spine+injury&stitle=Qatar+Med.+J.&title=Qatar+Medical+Journal&volume=20&issue=2&spage=62&epage=63&aulast=Arumugam&aufirst=Suresh+K.&auinit=S.K.&aufull=Arumugam+S.K.&coden=QMJAA&isbn=&pages=62-63&date=2011&auinit1=S&auinitm=K
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 636
TITLE
  Spinal cord injury: Outcomes of ventilatory weaning and extubation
AUTHOR NAMES
  Call M.S.; Kutcher M.E.; Izenberg R.A.; Singh T.; Cohen M.J.
AUTHOR ADDRESSES
  (Call M.S.; Kutcher M.E.; Izenberg R.A.; Singh T.; Cohen M.J., 
mcohen@sfghsurg.ucsf.edu) Department of Surgery, Ward 3A, San Francisco 
General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, United 
States.
CORRESPONDENCE ADDRESS
  M.J. Cohen, Department of Surgery, Ward 3A, San Francisco General Hospital, 
1001 Potrero Avenue, San Francisco, CA 94110, United States. Email: 
mcohen@sfghsurg.ucsf.edu
AiP/IP ENTRY DATE
  2011-07-28
FULL RECORD ENTRY DATE
  2012-01-03
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2011) 71:6 
(1673-1679). Date of Publication: December 2011
VOLUME
  71
ISSUE
  6
FIRST PAGE
  1673
LAST PAGE
  1679
DATE OF PUBLICATION
  December 2011
ISSN
  0022-5282
  1529-8809 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background:: Spinal cord injury (SCI) carries potentially devastating 
respiratory implications depending on injury level. Optimal strategies for 
mechanical ventilation in this setting remain poorly described. We reviewed 
our experience of ventilatory weaning and extubation outcomes in this 
patient population. Methods:: Eighty mechanically ventilated SCI patients 
over a 5-year period at a major Level I trauma center were assessed. Injury, 
clinical, and outcome data were extracted using our ICU database, chart, and 
registry data. Result:: We identified 80 patients with SCI, classified by 
anatomic injury and motor functional level. There were no differences in 
injury severity between patients who were successfully extubated and those 
who failed (all p = NS). Seventy-four percent were extubated at the time of 
discharge; successful extubation was associated with lower level of cord 
injury (p = 0.001) and higher arrival Glasgow Coma Scale score (13.7 ± 2.6 
vs. 10.8 ± 5.0, p = 0.021). Of extubation failures, 80% were due to 
pulmonary mechanical insufficiency, 22% inadequate pulmonary toilet, and 5% 
sedation or neurologic issues. Patients with weaning or extubation failures 
had longer ICU (29.9 days ± 24.5 days vs. 8.5 days ± 9.3 days; p < 0.001) 
and hospital stays (45.8 days ± 45.8 days vs. 26.6 days ± 23.9 days; p = 
0.009), and higher rates of ventilator-associated pneumonia (83% vs. 15%, p 
< 0.001). CONCLUSION:: Higher level of SCI correlates strongly with failure 
to wean and extubate; despite this, a subset of patients with high cord 
injury who can be safely weaned and extubated exists. A multicenter study is 
warranted to specifically identify patients with high SCI who merit weaning 
and extubation trials.Copyright © 2011 by Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; extubation; spinal cord injury (therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; clinical assessment; clinical examination; controlled study; disease registry; emergency health service; female; Glasgow coma scale; hospital discharge; hospitalization; human; injury severity; intensive care unit; length of stay; lung insufficiency; major clinical study; male; medical record review; motor performance; neuroanatomy; neurologic disease; priority journal; review; sedation; tracheobronchial toilet; traumatic brain injury (therapy); treatment failure; treatment outcome; ventilator associated pneumonia (complication, diagnosis); 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011706617
MEDLINE PMID
  21768893 (http://www.ncbi.nlm.nih.gov/pubmed/21768893)
PUI
  L51532210
DOI
  10.1097/TA.0b013e31821e87c2
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e31821e87c2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:10.1097%2FTA.0b013e31821e87c2&atitle=Spinal+cord+injury%3A+Outcomes+of+ventilatory+weaning+and+extubation&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=71&issue=6&spage=1673&epage=1679&aulast=Call&aufirst=Mariah+S.&auinit=M.S.&aufull=Call+M.S.&coden=JOTRF&isbn=&pages=1673-1679&date=2011&auinit1=M&auinitm=S
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 637
TITLE
  Selective intrabronchial air insufflation for acute lobar collapse in the 
surgical intensive care unit
AUTHOR NAMES
  Wohlauer M.V.; Moore E.E.; Haenel J.B.; Burlew C.C.; Barnett C.C.
AUTHOR ADDRESSES
  (Wohlauer M.V., max.wohlauer@ucdenver.edu; Moore E.E.; Haenel J.B.; Burlew 
C.C.; Barnett C.C.) Denver Health Medical Center and University of Colorado 
Denver, Denver, CO, United States.
CORRESPONDENCE ADDRESS
  M.V. Wohlauer, Denver Health Medical Center and University of Colorado 
Denver, Denver, CO, United States. Email: max.wohlauer@ucdenver.edu
AiP/IP ENTRY DATE
  2012-03-08
FULL RECORD ENTRY DATE
  2012-03-13
SOURCE
  Journal of Surgical Radiology (2011) 2:2 (178-181). Date of Publication: 
2011
VOLUME
  2
ISSUE
  2
FIRST PAGE
  178
LAST PAGE
  181
DATE OF PUBLICATION
  2011
ISSN
  2156-213X
  2156-4566 (electronic)
BOOK PUBLISHER
  Surgisphere Corporation, 4706 Carmen Ln, Durham, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atelectasis (diagnosis, therapy); oxygen therapy; 
EMTREE MEDICAL INDEX TERMS
  adult; airway pressure; article; artificial ventilation; case report; cervical spine dislocation (diagnosis, surgery); clinical feature; disease association; female; fever (diagnosis); fiberoptic bronchoscopy; human; hypoxemia (diagnosis); intensive care unit; medical history; osteosynthesis; outcome assessment; respiratory airflow; respiratory failure (surgery); spinal cord injury (diagnosis, surgery); thorax radiography; tracheostomy; treatment indication; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2012125886
PUI
  L364355848
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=2156213X&id=doi:&atitle=Selective+intrabronchial+air+insufflation+for+acute+lobar+collapse+in+the+surgical+intensive+care+unit&stitle=J.+Surg.+Radiol.&title=Journal+of+Surgical+Radiology&volume=2&issue=2&spage=178&epage=181&aulast=Wohlauer&aufirst=Max+V.&auinit=M.V.&aufull=Wohlauer+M.V.&coden=&isbn=&pages=178-181&date=2011&auinit1=M&auinitm=V
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 638
TITLE
  Portrait of an artist: A final study
AUTHOR NAMES
  Pinsky K.M.
AUTHOR ADDRESSES
  (Pinsky K.M., kmpnola@cox.net) 1525 State Street, New Orleans, LA 70118, 
United States.
CORRESPONDENCE ADDRESS
  K. M. Pinsky, 1525 State Street, New Orleans, LA 70118, United States. 
Email: kmpnola@cox.net
AiP/IP ENTRY DATE
  2011-12-26
FULL RECORD ENTRY DATE
  2012-01-03
SOURCE
  Ochsner Journal (2011) 11:4 (295-297). Date of Publication: 2011
VOLUME
  11
ISSUE
  4
FIRST PAGE
  295
LAST PAGE
  297
DATE OF PUBLICATION
  2011
ISSN
  1524-5012
BOOK PUBLISHER
  Ochsner Clinic, 1514 Jefferson Highway, New Orleans, United States.
ABSTRACT
  The life of an accomplished, independent 53-year-old woman is completely 
changed after surgery for a large, invasive spinal cord tumor. A lengthy, 
unsuccessful attempt at recovery and rehabilitation, compromised by multiple 
complications and hospitalizations, led to the patient's choice to come off 
the ventilator. Her end-of-life decision allowed her to die peacefully, 
surrounded by family and friends, all of whom were profoundly affected by 
the experience. © Academic Division of Ochsner Clinic Foundation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  attitude to death; patient decision making; terminal care; 
EMTREE MEDICAL INDEX TERMS
  adult; article; assisted ventilation; balance disorder; case report; clinical feature; computer assisted tomography; convalescence; female; general condition deterioration; hand paresthesia; human; human dignity; intensive care unit; neck pain; nuclear magnetic resonance imaging; outcome assessment; postoperative period; psychosocial care; quadriplegia; quality of life; respiratory failure (complication, surgery, therapy); spinal cord surgery; spinal cord tumor (diagnosis, surgery); surgical risk; tracheotomy; tumor invasion; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011696510
PUI
  L363113208
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15245012&id=doi:&atitle=Portrait+of+an+artist%3A+A+final+study&stitle=Ochsner+J.&title=Ochsner+Journal&volume=11&issue=4&spage=295&epage=297&aulast=Pinsky&aufirst=Karen+M.&auinit=K.M.&aufull=Pinsky+K.M.&coden=OJCOA&isbn=&pages=295-297&date=2011&auinit1=K&auinitm=M
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 639
TITLE
  Significance of early tracheotomy in treatment for patients with acute 
cervical spinal cord injury
AUTHOR NAMES
  Sun Y.-F.; Li Y.-P.; Liu P.
AUTHOR ADDRESSES
  (Sun Y.-F.; Li Y.-P.; Liu P.)
CORRESPONDENCE ADDRESS
  Y.-F. Sun,
AiP/IP ENTRY DATE
  2012-01-13
FULL RECORD ENTRY DATE
  2012-01-17
SOURCE
  Journal of Jilin University Medicine Edition (2011) 37:6 (1133-1135). Date 
of Publication: 28 Nov 2011
VOLUME
  37
ISSUE
  6
FIRST PAGE
  1133
LAST PAGE
  1135
DATE OF PUBLICATION
  28 Nov 2011
ISSN
  1671-587X
BOOK PUBLISHER
  Jilin University Press, 8 Xinmin St., Changchun, China.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  acute disease; article; early intervention; human; spinal cord injury; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  Chinese
LANGUAGE OF SUMMARY
  Chinese
EMBASE ACCESSION NUMBER
  2012018828
PUI
  L364047943
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1671587X&id=doi:&atitle=Significance+of+early+tracheotomy+in+treatment+for+patients+with+acute+cervical+spinal+cord+injury&stitle=J.+Jilin+Univ.+Med.+Ed.&title=Journal+of+Jilin+University+Medicine+Edition&volume=37&issue=6&spage=1133&epage=1135&aulast=Sun&aufirst=Yi-Fu&auinit=Y.-F.&aufull=Sun+Y.-F.&coden=JDXYA&isbn=&pages=1133-1135&date=2011&auinit1=Y&auinitm=-F
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 640
TITLE
  Methicillin-resistant Staphylococcus aureus (MRSA) is an underestimated 
problem in traumatic vertebral column fractures and spinal cord injury. A 
prevalence and riskanalysis from 1996-2008
AUTHOR NAMES
  Eichler M.; Akbar M.; Wiedenhöfer B.; Bruckner T.
AUTHOR ADDRESSES
  (Eichler M.; Akbar M.; Wiedenhöfer B.; Bruckner T.) Orthopädische 
Universitätsklinik, Spine Center, Heidelberg, Germany.
CORRESPONDENCE ADDRESS
  M. Eichler, Orthopädische Universitätsklinik, Spine Center, Heidelberg, 
Germany.
FULL RECORD ENTRY DATE
  2014-02-17
SOURCE
  European Spine Journal (2011) 20:11 (2004). Date of Publication: November 
2011
VOLUME
  20
ISSUE
  11
FIRST PAGE
  2004
DATE OF PUBLICATION
  November 2011
CONFERENCE NAME
  6th German Spine Conference - Annual Meeting of the German Spine Society
CONFERENCE LOCATION
  Hamburg, Germany
CONFERENCE DATE
  2011-12-08 to 2011-12-10
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Intoduction: Patients with traumatic spinal column fractures are faced with 
a high re-hospitalisation rate and are therefore at risk for a 
MRSA-colonisation. Methods: Retrospective database analysis between 
1996-2008. Results: The total number of all treated was 3527. Isolation mean 
time was 67.4 days. The MRSA-prevalence was 11.8%. MRSA Patients age was 
58.9 (vs.55.1 y.; p=0.0018). Male Patients were more often colonizised then 
female (15% vs. 6%; p<.0001). Cumulative time of hospital stays and ICU-time 
was significantly higher (229.7 vs. 93.6 days and 25.6 vs. 4.2 days). The 
number of re-hospitalization was higher for MRSA patients (2.5 vs.1.6). 
Patients with cervical injury showed a 14.5% MRSA-rate. Every additional 
year of age elevates the risk for MRSA 1.2 %. Male had a 2.8 times higher 
risk for MRSA. The risk of MRSA colonization increased per day of hospital 
stay about 3.5% %. The risk for MRSA colonization increases with the number 
of hospital stay ( 3: 13%; 4: 25%. Pressure sores causes a 7 times higher 
MRSA-risk. Patients with tracheotomy showed a 1.9% higher risk of 
MRSA-colonization. Diabetes mellitus is associated w/ a 2.4 higher risk of 
MRSA. Patients from nurseryhomes have a 17 times elevated MRSA-acquisition 
risk. The eradication rate was 70%. The mortality-rate was significantly 
higher (20%). Conclusion: This study emphasizes the high MRSA-prevalence and 
elevated risk in patients with vertebral column fractures with SCI. Clinical 
work-up of these patients should include a standardized MRSA-screening and 
initial isolation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fracture; methicillin resistant Staphylococcus aureus; prevalence; society; spinal cord injury; spine; 
EMTREE MEDICAL INDEX TERMS
  data base; decubitus; diabetes mellitus; female; hospitalization; human; injury; male; mortality; patient; risk; screening; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71313951
DOI
  10.1007/s00586-011-2033-x
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-011-2033-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-011-2033-x&atitle=Methicillin-resistant+Staphylococcus+aureus+%28MRSA%29+is+an+underestimated+problem+in+traumatic+vertebral+column+fractures+and+spinal+cord+injury.+A+prevalence+and+riskanalysis+from+1996-2008&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=20&issue=11&spage=2004&epage=&aulast=Eichler&aufirst=M.&auinit=M.&aufull=Eichler+M.&coden=&isbn=&pages=2004-&date=2011&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 641
TITLE
  Paediatric spinal cord injury: Review of patients treated in a tertiary 
level pediatric hospital
AUTHOR NAMES
  Vinhas Da Silva A.; Vieira M.; Rios J.; Camilo C.; Abecasis F.; Correia M.
AUTHOR ADDRESSES
  (Vinhas Da Silva A.; Vieira M.; Rios J.; Camilo C.; Abecasis F.; Correia M.) 
Hospital de Santa Maria, Lisbon, Portugal.
CORRESPONDENCE ADDRESS
  A. Vinhas Da Silva, Hospital de Santa Maria, Lisbon, Portugal.
FULL RECORD ENTRY DATE
  2012-01-16
SOURCE
  Intensive Care Medicine (2011) 37 SUPPL. 2 (S408). Date of Publication: 
November 2011
VOLUME
  37
FIRST PAGE
  S408
DATE OF PUBLICATION
  November 2011
CONFERENCE NAME
  22nd Annual Congress of the European Society of Paediatric and Neonatal 
Intensive Care, ESPNIC 2011
CONFERENCE LOCATION
  Hannover, Germany
CONFERENCE DATE
  2011-11-02 to 2011-11-05
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background and aims: Spinal cord injury (SCI) is rare in children but is 
often associated with significant morbidity and prolonged stay in PICU. The 
main objective of this review was to determine the epidemiology, clinical 
presentation, imaging studies, treatment and outcome of these patients. 
Patients and methods: Retrospective review of patients with SCI admitted to 
our PICU between 2003 and 2011. Results: We included 14 patients, 10 were 
male (71.4%); the mean age was 10 years (3-17). Motor vehicle accidents were 
the most common cause (42.8%), followed by diving accidents (30.8%). Head 
trauma was present in 7 patients (50%). Cervical injury represented 78.6% of 
SCI. Eight patients (57.1%) had complete spinal injury on admission. 
Vertebral fractures were the most common radiological findings (64.3%). Nine 
patients (64.3%) were treated surgically, 8 received steroids (57.1%) and 
five (28.6%) needed vasoactive drugs. Nine patients (64.3%) needed 
mechanical ventilation (average: 8.2 days; 1-24), none was tracheostomized. 
Respiratory rehabilitation comprehended daily chest physiotherapy and cough 
assist. Main complications were urinary (28.6%) and respiratory (50.0%) 
infections. The average length of PICU stay was 19.2 days (4-46). Nine 
patients were transferred to the ward and five directly to a rehabilitation 
centre. At discharge, six patients were tetraplegic and four paraplegic. No 
patient died. Conclusions: Most children had cervical injury, as expected 
due to their anatomical specificities. Very good respiratory rehabilitation 
care avoided tracheostomies in this series. Multidisciplinary approach 
maximizes recovery.
EMTREE DRUG INDEX TERMS
  steroid; vasoactive agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  human; newborn intensive care; patient; pediatric hospital; society; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  accident; artificial ventilation; breathing exercise; child; coughing; diving; epidemiology; head injury; imaging; infection; injury; male; morbidity; paraplegia; rehabilitation; rehabilitation care; spine fracture; spine injury; tracheostomy; traffic accident; ward; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70638703
DOI
  10.1007/s00134-011-2387-x
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-011-2387-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-011-2387-x&atitle=Paediatric+spinal+cord+injury%3A+Review+of+patients+treated+in+a+tertiary+level+pediatric+hospital&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=37&issue=&spage=S408&epage=&aulast=Vinhas+Da+Silva&aufirst=A.&auinit=A.&aufull=Vinhas+Da+Silva+A.&coden=&isbn=&pages=S408-&date=2011&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 642
TITLE
  Surgical treatment of a traumatic C 5/ 6 transdiscal luxation with 
symptomatic spinal cord injury in a 13 month old child
AUTHOR NAMES
  Stier R.; Gösling T.; Otte D.; Krettek C.; Christian M.
AUTHOR ADDRESSES
  (Stier R.; Gösling T.; Otte D.; Krettek C.; Christian M.) Medizinische 
Hochschule Hannover, Unfallchirirgie, Hannover, Germany.
CORRESPONDENCE ADDRESS
  R. Stier, Medizinische Hochschule Hannover, Unfallchirirgie, Hannover, 
Germany.
FULL RECORD ENTRY DATE
  2014-02-17
SOURCE
  European Spine Journal (2011) 20:11 (2042-2043). Date of Publication: 
November 2011
VOLUME
  20
ISSUE
  11
FIRST PAGE
  2042
LAST PAGE
  2043
DATE OF PUBLICATION
  November 2011
CONFERENCE NAME
  6th German Spine Conference - Annual Meeting of the German Spine Society
CONFERENCE LOCATION
  Hamburg, Germany
CONFERENCE DATE
  2011-12-08 to 2011-12-10
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background: With around 0.2 % of all fractures in childhood, spine injuries 
are rare in the pediatric population. There are 83% fractures, 30% with 
neurological symptoms. Pediatric cases of cervical spine injury account for 
less then 10 % of all such injuries and approximately 40 to 60 % of all 
pediatric spine injuries occur in the cervical region. In most of the cases, 
injuries of the cervical spine can be treat conservative. If a surcigal 
treatment is indicated, the reposition of flexion/ distraction injury in the 
close way is just in rare cases possible. Because ligamentous or discal 
injuries in the lower cervical spine are not stabile, surcigal treatment is 
indicated, preverably with a ventral spondylodesis. Because of few number of 
cases , there exist no common management treating lower cervical spine 
injuries in child. History: This 13-month-old girl was riding in a 
foreward-facing booster seat anchored next to the driver seat by a lap belt. 
It was raining, the road was slippery. The car breaked, left the road in the 
ditch nearby and hit a stone wall with 70 km/ h. At the scene, the 
responders found the child in the car sitting in the booster seat, she was 
awake, cried and moved legs and arms. There were no signs of injury. On 
arrival in the clinic she got tiered, the pupils were isocor. Flaccid 
paralysis oft he legs, no abdominal skin reflex, no reflex of pain under the 
mamils. She moved both arms, the babinski was positiv on the right site. 
Head and cervical spine MRI scans were obtained. It showed an C 5/6 
transdiscal luxation with a break of the intervertebral disc of C 6 and oft 
he dorsal structures C5/6 and an oedemic swalling oft he spinal cord C5/6. 
The girl got intubated, got a stiffneck and 30 mg Dexamethason. A CT-scan 
oft he cervical spine showed a distraction injury at the C5-6 level with a 9 
mm gap. She got right away in the OR. Therapy: Because the intervertebral 
disc seamed to be intact, we decided for a halo-fixation and a ventral 
stabilisation C5/6 without spondylodesis. In between we placed the 
halo-fixateur the injury showed up as instabil, so we decided to do a 
spondylodesis with a 4-hole 2,5 mm APTUS-plate and two angle stable screws 
at C 5 on C 6. Afterwards the halo west could placed. We fixed the head in a 
reclination position. After two days we made an MRI controll scan, which 
still showed the cord compression with a parenchymal bleeding. There was 
still a flaccid paralysis of the legs, no muscle reflexes. Arms and hands 
could be moved, also for drinking and eating with the spoon. After 3 weeks 
the patient got respiratory insufficient, so she got a tracheostoma. At the 
same time we removed the halo-fixateur and fixed the spine with a Miami-J- 
Collar. Further examinations schowed an anhidrosis and an uninhibited 
neurogenic bladder, but a functional anal shincter tonus. 4 weeks after 
trauma the patient went to a rehabilitation. The X-ray showed no dislocation 
of the osteosynthesis, so we removed the implants one year after trauma. 
After 24 and 36 month the girl was in good development but she had still 
paraparesis of her legs. There was no pain at the cercival spine, the 
extension/ flexion and rotation was free.
EMTREE DRUG INDEX TERMS
  dexamethasone; hexamethonium bromide; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child; dislocation; human; society; spinal cord injury; spine; surgery; 
EMTREE MEDICAL INDEX TERMS
  anhidrosis; arm; bleeding; car; cervical spine; cervical spine injury; child restraint system; childhood; compression; computer assisted tomography; drinking; eating; examination; female; flaccid paralysis; fracture; girl; hospital; implant; injury; intervertebral disk; leg; muscle reflex; muscle tone; neurogenic bladder; neurologic disease; nuclear magnetic resonance imaging; osteosynthesis; pain; paraplegia; patient; population; reflex; rehabilitation; sitting; skin; spinal cord; spine injury; spondylodesis; therapy; trachea stoma; X ray; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71314046
DOI
  10.1007/s00586-011-2033-x
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-011-2033-x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-011-2033-x&atitle=Surgical+treatment+of+a+traumatic+C+5%2F+6+transdiscal+luxation+with+symptomatic+spinal+cord+injury+in+a+13+month+old+child&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=20&issue=11&spage=2042&epage=2043&aulast=Stier&aufirst=R.&auinit=R.&aufull=Stier+R.&coden=&isbn=&pages=2042-2043&date=2011&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 643
TITLE
  Artificial external glottic device for passive lung insufflation
AUTHOR NAMES
  Kim D.H.; Kang S.-W.; Park Y.G.; Choi W.A.; Lee H.R.
AUTHOR ADDRESSES
  (Kim D.H.) Department of Rehabilitation Medicine, College of Medicine, Kyung 
Hee University, Seoul, South Korea.
(Kang S.-W.; Park Y.G.; Choi W.A., skyler02@wku.ac.kr) Department of 
Rehabilitation Medicine, Rehabilitation Institute of Muscular Disease, 
Yonsei University College of Medicine, Seoul, South Korea.
(Lee H.R.) Department of Family Medicine, Yonsei University College of 
Medicine, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  W. A. Choi, Department of Rehabilitation Medicine, Rehabilitation Institute 
of Muscular Disease, Yonsei University College of Medicine, 211 Eonju-ro, 
Gangnam-gu, Seoul 135-720, South Korea. Email: skyler02@wku.ac.kr
AiP/IP ENTRY DATE
  2011-11-03
FULL RECORD ENTRY DATE
  2011-11-07
SOURCE
  Yonsei Medical Journal (2011) 52:6 (972-976). Date of Publication: November 
2011
VOLUME
  52
ISSUE
  6
FIRST PAGE
  972
LAST PAGE
  976
DATE OF PUBLICATION
  November 2011
ISSN
  0513-5796
BOOK PUBLISHER
  Yonsei University College of Medicine, Shinchon dong 134, Seodaemoon ku, 
Seoul, South Korea.
ABSTRACT
  Purpose: For patients with neuromuscular disease, air stacking, which 
inflates the lungs to deep volumes, is important for many reasons. However, 
neuromuscular patients with severe glottic dysfunction or indwelling 
tracheostomy tubes cannot air stack effectively. For these patients, we 
developed a device that permits deep lung insufflations substituting for 
glottic function. Materials and Methods: Thirty-seven patients with 
bulbar-innervated muscle weakness and/or tracheostomies were recruited. 
Twenty-three had amyotrophic lateral sclerosis, and 14 were tetraplegic 
patients due to cervical spinal cord injury. An artificial external glottic 
device (AEGD) was used to permit passive deep lung insufflation. In order to 
confirm the utility of AEGD, vital capacity, maximum insufflation capacity 
(MIC), and lung insufflation capacity (LIC) with AEGD (LICA) were measured. 
Results: For 30 patients, MICs were initially zero. However, with the use of 
the AEGD, LICA was measurable for all patients. The mean LICA was 
1,622.7±526.8 mL. Although MIC was measurable for the remaining 7 patients 
without utilizing the AEGD, it was significantly less than LICA, which was 
1,084.3±259.9 mL and 1,862.9±248 mL, respectively (p<0.05). Conclusion: The 
AEGD permits lung insufflation by providing deeper lung volumes than 
possible by air stacking. © Yonsei University College of Medicine 2011.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aeration; artificial external glottic device; lung insufflation; medical device; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; amyotrophic lateral sclerosis (diagnosis); article; bulbar paralysis; cervical spinal cord injury (diagnosis); clinical article; female; human; larynx disorder; lung function; lung function test; lung hemodynamics; male; quadriplegia; tracheostomy; vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011592810
MEDLINE PMID
  22028162 (http://www.ncbi.nlm.nih.gov/pubmed/22028162)
PUI
  L362809839
DOI
  10.3349/ymj.2011.52.6.972
FULL TEXT LINK
  http://dx.doi.org/10.3349/ymj.2011.52.6.972
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=05135796&id=doi:10.3349%2Fymj.2011.52.6.972&atitle=Artificial+external+glottic+device+for+passive+lung+insufflation&stitle=Yonsei+Med.+J.&title=Yonsei+Medical+Journal&volume=52&issue=6&spage=972&epage=976&aulast=Kim&aufirst=Dong+Hyun&auinit=D.H.&aufull=Kim+D.H.&coden=YOMJA&isbn=&pages=972-976&date=2011&auinit1=D&auinitm=H
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 644
TITLE
  Vitamin B(12) deficiency as a cause of delirium in a patient with spinal 
cord injury
AUTHOR NAMES
  Harrington A.L.; Dixon T.M.; Ho C.H.
AUTHOR ADDRESSES
  (Harrington A.L., harringtonal@upmc.edu) Department of Physical Medicine and 
Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States.
(Dixon T.M.; Ho C.H.) Louis Stokes Cleveland Department of Veterans Affairs 
Medical Center, Cleveland, OH, United States.
(Ho C.H.) Department of Physical Medicine and Rehabilitation, Case Western 
Reserve University, Cleveland, OH, United States.
CORRESPONDENCE ADDRESS
  A.L. Harrington, UPMC Mercy Hospital, Bldg D, PMandR Office, 1400 Locust St, 
Pittsburgh, PA 15219, United States. Email: harringtonal@upmc.edu
AiP/IP ENTRY DATE
  2011-11-03
FULL RECORD ENTRY DATE
  2011-11-08
SOURCE
  Archives of Physical Medicine and Rehabilitation (2011) 92:11 (1917-1920). 
Date of Publication: November 2011
VOLUME
  92
ISSUE
  11
FIRST PAGE
  1917
LAST PAGE
  1920
DATE OF PUBLICATION
  November 2011
ISSN
  0003-9993
  1532-821X (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  A man with spinal cord injury (SCI) and multiple medical comorbidities had 
new-onset delirium during his 14th month of hospitalization. Diagnostic 
workup did not elicit an obvious etiology for mental status changes. 
Delirium persisted despite psychiatry intervention, and he was unable to be 
weaned from the ventilator because of prolonged agitation. Routine anemia 
workup revealed a possible untreated vitamin B(12) deficiency, although 
laboratory values were inconclusive. Empiric treatment with cyanocobalamin 
injections was initiated, and his delirium remarkably resolved after 3 weeks 
of treatment. We provide a concise review of the etiologies and varied 
clinical presentations of vitamin B(12) deficiency. As illustrated in this 
case, classic laboratory findings may not appear, and neurologic impairments 
from SCI can obscure the physical signs of deficiency, making diagnosis 
difficult. Empiric treatment may be indicated in cases of neuropsychiatric 
abnormalities not explained by other causes. © 2011 American Congress of 
Rehabilitation Medicine.
EMTREE DRUG INDEX TERMS
  albumin (endogenous compound); bilirubin (endogenous compound); calcium (endogenous compound); clonazepam; creatinine (endogenous compound); cyanocobalamin (drug therapy); ferritin (endogenous compound); folic acid (endogenous compound); haloperidol; haptoglobin (endogenous compound); hemoglobin (endogenous compound); homocysteine (endogenous compound); iron (endogenous compound); lactate dehydrogenase (endogenous compound); methylmalonic acid (endogenous compound); olanzapine; transferrin (endogenous compound); urea (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  B12 deficiency (drug therapy, drug therapy); delirium (drug therapy, drug therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  abdominal aortic aneurysm (surgery); adult; agitation; albumin blood level; anemia; anxiety disorder; article; artificial ventilation; assisted ventilation; bilirubin blood level; calcium blood level; case report; Clostridium difficile infection; colitis; comorbidity; creatinine blood level; decubitus; depression; disorientation; drug substitution; drug withdrawal; erythrocyte count; ferritin blood level; folic acid blood level; hallucination; hematocrit; hemodialysis; hemoglobin blood level; hospital readmission; human; intensive care; intestine ischemia (surgery); intestine surgery; iron binding capacity; iron blood level; kidney infarction (therapy); lactate dehydrogenase blood level; length of stay; leukocyte count; male; mean corpuscular volume; mental health; paraplegia; platelet count; pneumonia (drug resistance); psychotherapy; recurrent infection; rehabilitation care; respiratory failure; reticulocyte count; septicemia; somnolence; tracheostomy; transferrin blood level; urea nitrogen blood level; urinary tract infection; vitamin blood level; wound healing; 
CAS REGISTRY NUMBERS
  bilirubin (18422-02-1, 635-65-4)
  calcium (14092-94-5, 7440-70-2)
  clonazepam (1622-61-3)
  creatinine (19230-81-0, 60-27-5)
  cyanocobalamin (53570-76-6, 68-19-9, 8064-09-3)
  ferritin (9007-73-2)
  folic acid (59-30-3, 6484-89-5)
  haloperidol (52-86-8)
  haptoglobin (9087-69-8)
  hemoglobin (9008-02-0)
  homocysteine (454-28-4, 6027-13-0)
  iron (14093-02-8, 53858-86-9, 7439-89-6)
  lactate dehydrogenase (9001-60-9)
  methylmalonic acid (516-05-2)
  olanzapine (132539-06-1)
  transferrin (82030-93-1)
  urea (57-13-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Clinical and Experimental Pharmacology (30)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011595073
MEDLINE PMID
  22032226 (http://www.ncbi.nlm.nih.gov/pubmed/22032226)
PUI
  L362816869
DOI
  10.1016/j.apmr.2011.06.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2011.06.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2Fj.apmr.2011.06.003&atitle=Vitamin+B12+deficiency+as+a+cause+of+delirium+in+a+patient+with+spinal+cord+injury&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=92&issue=11&spage=1917&epage=1920&aulast=Harrington&aufirst=Amanda+L.&auinit=A.L.&aufull=Harrington+A.L.&coden=APMHA&isbn=&pages=1917-1920&date=2011&auinit1=A&auinitm=L
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 645
TITLE
  Cervical spine fracture. Tracheotomy?
ORIGINAL (NON-ENGLISH) TITLE
  Fractura cervical ¿Traqueotomía?
AUTHOR NAMES
  Díaz de Cerio Canduela P.; López J.A.P.; Barrutia V.G.
AUTHOR ADDRESSES
  (Díaz de Cerio Canduela P., pdiazdecerio@yahoo.es; López J.A.P.) Servicio de 
Otorrinolaringología, Hospital San Pedro, Logroño, La Rioja, Spain.
(Barrutia V.G.) Servicio de Medicina Intensiva, Hospital San Pedro, Logroño, 
La Rioja, Spain.
CORRESPONDENCE ADDRESS
  P. Díaz de Cerio Canduela, Servicio de Otorrinolaringología, Hospital San 
Pedro, Logroño, La Rioja, Spain. Email: pdiazdecerio@yahoo.es
AiP/IP ENTRY DATE
  2010-12-02
FULL RECORD ENTRY DATE
  2011-11-22
SOURCE
  Acta Otorrinolaringologica Espanola (2011) 62:6 (479-480). Date of 
Publication: November 2011
VOLUME
  62
ISSUE
  6
FIRST PAGE
  479
LAST PAGE
  480
DATE OF PUBLICATION
  November 2011
ISSN
  0001-6519
  1988-3013 (electronic)
BOOK PUBLISHER
  Ediciones Doyma, S.L., Travesera de Gracia 17-21, Barcelona, Spain.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  article; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  Spanish
EMBASE ACCESSION NUMBER
  2011624808
MEDLINE PMID
  21112570 (http://www.ncbi.nlm.nih.gov/pubmed/21112570)
PUI
  L51169447
DOI
  10.1016/j.otorri.2010.09.013
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.otorri.2010.09.013
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016519&id=doi:10.1016%2Fj.otorri.2010.09.013&atitle=Cervical+spine+fracture.+Tracheotomy%3F&stitle=Acta+Otorrinolaringol.+Esp.&title=Acta+Otorrinolaringologica+Espanola&volume=62&issue=6&spage=479&epage=480&aulast=D%C3%ADaz+de+Cerio+Canduela&aufirst=Pedro&auinit=P.&aufull=D%C3%ADaz+de+Cerio+Canduela+P.&coden=AOTEA&isbn=&pages=479-480&date=2011&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 646
TITLE
  Prompt restoration of airway along with rapid neurological recovery 
following ultrasonography-guided needle aspiration of a tubercular 
retropharyngeal abscess causing airway obstruction
AUTHOR NAMES
  Borgohain B.
AUTHOR ADDRESSES
  (Borgohain B., bhaskarborg@gmail.com) Department of Orthopaedics and Trauma, 
North-Eastern Indira Gandhi Regional Institute of Health and Medical 
Sciences, Mawdiangdiang, Shillong, Meghalaya 793018, India.
CORRESPONDENCE ADDRESS
  B. Borgohain, Department of Orthopaedics and Trauma, North-Eastern Indira 
Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, 
Shillong, Meghalaya 793018, India. Email: bhaskarborg@gmail.com
AiP/IP ENTRY DATE
  2011-11-21
FULL RECORD ENTRY DATE
  2011-12-06
SOURCE
  Singapore Medical Journal (2011) 52:11 (e229-e231). Date of Publication: 
November 2011
VOLUME
  52
ISSUE
  11
DATE OF PUBLICATION
  November 2011
ISSN
  0037-5675
BOOK PUBLISHER
  Singapore Medical Association, 2 College Road, Level 2, Singapore, 
Singapore.
ABSTRACT
  Upper respiratory obstruction in cervical spine tuberculosis rarely occurs 
due to retropharyngeal cold abscess or secondarily from its rupture. Options 
for securing the airway are intubation, tracheostomy and needle aspiration 
or surgical drainage. A young boy presented with neck pain, quadriparesis 
and stridor, suggesting subacute airway obstruction in advanced tubercular 
spondylodiscitis of cervical spine C3-C4 (cervical 3rd and 4th level) with 
extradural compressive myelopathy (C3-C5) and a large retropharyngeal cold 
abscess. An urgent ultrasonography-guided needle aspiration with a head low 
position through the left posterior triangle was performed with adequate 
precautions and back-up for advanced airway management. Needle aspiration 
yielded 200 ml of pus. Stridor and hoarseness of voice decreased 
immediately. Within two-and-a-half hours, the patient improved 
neurologically. Although guided needle aspiration is one of the treatment 
options, there is a strong tendency to undermine this technique in favour of 
other options, especially surgery.
EMTREE DRUG INDEX TERMS
  ciprofloxacin (drug therapy, intravenous drug administration); isoniazid (drug therapy); rifampicin (drug therapy); streptomycin (drug therapy, intramuscular drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (complication, therapy); bronchial aspiration procedure; retropharyngeal abscess; 
EMTREE MEDICAL INDEX TERMS
  adult; article; body position; bone graft; case report; clinical effectiveness; clinical feature; disease association; disease duration; echography; general condition improvement; hoarseness; human; human tissue; male; neurologic examination; nuclear magnetic resonance imaging; oxygen therapy; spinal cord disease; spine radiography; spondylitis; stridor; therapy effect; traction therapy; tuberculous osteomyelitis (diagnosis, drug therapy, surgery, therapy); 
CAS REGISTRY NUMBERS
  ciprofloxacin (85721-33-1)
  isoniazid (54-85-3, 62229-51-0, 65979-32-0)
  rifampicin (13292-46-1)
  streptomycin (57-92-1)
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011626790
MEDLINE PMID
  22173262 (http://www.ncbi.nlm.nih.gov/pubmed/22173262)
PUI
  L362920946
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00375675&id=doi:&atitle=Prompt+restoration+of+airway+along+with+rapid+neurological+recovery+following+ultrasonography-guided+needle+aspiration+of+a+tubercular+retropharyngeal+abscess+causing+airway+obstruction&stitle=Singapore+Med.+J.&title=Singapore+Medical+Journal&volume=52&issue=11&spage=&epage=&aulast=Borgohain&aufirst=B.&auinit=B.&aufull=Borgohain+B.&coden=SIMJA&isbn=&pages=-&date=2011&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 647
TITLE
  In reference to acute airway obstruction in cervical spinal procedures with 
bone morphogenetic proteins
AUTHOR NAMES
  Buchowski J.M.; Riew K.D.; Nussenbaum B.
AUTHOR ADDRESSES
  (Buchowski J.M.; Riew K.D.) Department of Orthopaedic Surgery, Center for 
Spinal Tumors, Washington University, St. Louis, MI, United States.
(Nussenbaum B.) Department of Otolaryngology, Washington University, St. 
Louis, MI, United States.
CORRESPONDENCE ADDRESS
  J.M. Buchowski, Department of Orthopaedic Surgery, Center for Spinal Tumors, 
Washington University, St. Louis, MI, United States.
AiP/IP ENTRY DATE
  2011-09-09
FULL RECORD ENTRY DATE
  2011-11-09
SOURCE
  Laryngoscope (2011) 121:11 (2501). Date of Publication: November 2011
VOLUME
  121
ISSUE
  11
FIRST PAGE
  2501
DATE OF PUBLICATION
  November 2011
ISSN
  0023-852X
  1531-4995 (electronic)
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  bone morphogenetic protein; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute disease; airway obstruction; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  dysphagia; dyspnea; hematoma; hospitalization; human; incidence; intubation; letter; mortality; perioperative period; postoperative period; priority journal; respiratory failure; swelling; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Clinical and Experimental Biochemistry (29)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2011596807
MEDLINE PMID
  21898420 (http://www.ncbi.nlm.nih.gov/pubmed/21898420)
PUI
  L51610739
DOI
  10.1002/lary.21784
FULL TEXT LINK
  http://dx.doi.org/10.1002/lary.21784
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0023852X&id=doi:10.1002%2Flary.21784&atitle=In+reference+to+acute+airway+obstruction+in+cervical+spinal+procedures+with+bone+morphogenetic+proteins&stitle=Laryngoscope&title=Laryngoscope&volume=121&issue=11&spage=2501&epage=&aulast=Buchowski&aufirst=Jacob+M.&auinit=J.M.&aufull=Buchowski+J.M.&coden=LARYA&isbn=&pages=2501-&date=2011&auinit1=J&auinitm=M
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 648
TITLE
  Diffuse idiopathic skeletal hyperostosis of the cervical spine: An 
underestimated cause of dysphagia and airway obstruction
AUTHOR NAMES
  Verlaan J.-J.; Boswijk P.F.E.; De Ru J.A.; Dhert W.J.A.; Oner F.C.
AUTHOR ADDRESSES
  (Verlaan J.-J., j.j.verlaan@umcutrecht.nl; Boswijk P.F.E.; Dhert W.J.A.; 
Oner F.C.) Department of Orthopaedics, University Medical Center Utrecht, 
Heidelberglaan 100, 3584CX, Utrecht, Netherlands.
(De Ru J.A.) Department of Otorhinolaryngology, Central Military Hospital, 
Heidelberglaan 100, 3584CX, Utrecht, Netherlands.
CORRESPONDENCE ADDRESS
  J.-J. Verlaan, Department of Orthopaedics, University Medical Center 
Utrecht, Heidelberglaan 100, 3584CX, Utrecht, Netherlands. Email: 
j.j.verlaan@umcutrecht.nl
AiP/IP ENTRY DATE
  2012-09-14
FULL RECORD ENTRY DATE
  2012-09-20
SOURCE
  Spine Journal (2011) 11:11 (1058-1067). Date of Publication: November 2011
VOLUME
  11
ISSUE
  11
FIRST PAGE
  1058
LAST PAGE
  1067
DATE OF PUBLICATION
  November 2011
ISSN
  1529-9430
  1878-1632 (electronic)
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  BACKGROUND CONTEXT: Diffuse idiopathic skeletal hyperostosis (DISH) is a 
common but underdiagnosed condition relating to ossification of spinal 
ligaments that can cause compression of the esophagus and trachea. According 
to case reports, dysphagia or airway obstruction resulting from DISH is a 
rare occurrence. PURPOSE: This study was intended to identify all published 
cases of dysphagia and/or airway obstruction resulting from DISH to increase 
the epidemiologic/clinical knowledge of these related conditions. STUDY 
DESIGN: A systematic review of the literature was performed. METHODS: The 
articles resulting from the systematic PubMed/EMBASE search of the 
literature were closely read, and predefined parameters were scored. 
RESULTS: The search yielded a total of 118 articles (95 case reports and 23 
case series) describing 204 patients with dysphagia and/or airway 
obstruction resulting from DISH. The number of cases demonstrated a steady 
increase from 1980 to 2009. This might be a real effect not ascribable to 
publication bias or expansion of the medical literature alone. CONCLUSIONS: 
Diffuse idiopathic skeletal hyperostosis as a cause of dysphagia and/or 
airway obstruction may be an increasing and underappreciated phenomenon. 
Diffuse idiopathic skeletal hyperostosis should be included in the 
differential diagnosis of dysphagia and airway obstruction. ©2011 Elsevier 
Inc. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (complication, surgery, therapy); diffuse idiopathic skeletal hyperostosis; dysphagia (complication, surgery, therapy); hyperostosis; idiopathic disease; 
EMTREE MEDICAL INDEX TERMS
  alcohol abuse; aspiration pneumonia; backache; body weight loss; cerebrovascular accident; cerebrovascular accident (complication); cervical spine; chronic obstructive lung disease; comorbidity; conservative treatment; coronary artery disease; differential diagnosis; dysphonia; dyspnea; endotracheal intubation; esophagus function disorder (complication); gastroesophageal reflux; general condition deterioration; heart arrhythmia; heart infarction; human; hyperlipidemia; hypertension; laryngeal nerve injury (complication); ligament; neck pain; non insulin dependent diabetes mellitus; obesity; odynophagia; ossification; osteoarthritis; peripheral occlusive artery disease; pneumonia (complication); priority journal; pulmonary aspiration; radiculopathy; range of motion; respiratory failure; retinol intoxication; review; sleep disordered breathing; spinal cord disease; stridor; systematic review; thorax outlet syndrome; tracheostomy; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2012525802
MEDLINE PMID
  22015236 (http://www.ncbi.nlm.nih.gov/pubmed/22015236)
PUI
  L365590419
DOI
  10.1016/j.spinee.2011.09.014
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.spinee.2011.09.014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15299430&id=doi:10.1016%2Fj.spinee.2011.09.014&atitle=Diffuse+idiopathic+skeletal+hyperostosis+of+the+cervical+spine%3A+An+underestimated+cause+of+dysphagia+and+airway+obstruction&stitle=Spine+J.&title=Spine+Journal&volume=11&issue=11&spage=1058&epage=1067&aulast=Verlaan&aufirst=Jorrit-Jan&auinit=J.-J.&aufull=Verlaan+J.-J.&coden=SJPOA&isbn=&pages=1058-1067&date=2011&auinit1=J&auinitm=-J
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 649
TITLE
  Managing high-level cervical spinal cord injuries: Intensivist's point of 
view
AUTHOR NAMES
  Pease S.
AUTHOR ADDRESSES
  (Pease S.) Réanimation Chirurgicale Polyvalente, Hôpital Nicolas-Beaujon, 
100 Boulevard du Général-Leclerc, Clichy-La-Garenne, France.
CORRESPONDENCE ADDRESS
  S. Pease, Réanimation Chirurgicale Polyvalente, Hôpital Nicolas-Beaujon, 100 
Boulevard du Général-Leclerc, Clichy-La-Garenne, France.
FULL RECORD ENTRY DATE
  2011-09-26
SOURCE
  Annals of Physical and Rehabilitation Medicine (2011) 54 SUPPL. 1 (e114). 
Date of Publication: October 2011
VOLUME
  54
FIRST PAGE
  e114
DATE OF PUBLICATION
  October 2011
CONFERENCE NAME
  26e Congres de Medecine Physique et de Readaptation
CONFERENCE LOCATION
  Nantes, France
CONFERENCE DATE
  2011-10-13 to 2011-10-15
ISSN
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS
ABSTRACT
  Incidence of spinal cord injury in France is estimated at 1000 to 2000 
patients per year. The diaphragm is innerved by the phrenic nerves that are 
formed from the cervical nerves C3, C4, C5. High tetraplegia is defined as a 
spinal cord injury for a level set from C1 to C4. More and more patients 
suffering such high level are now being admitted alive to trauma centres 
because of major progress made in pre-hospital management. Optimal 
pre-hospital management lies on direct admission to dedicated trauma centre, 
cautious cervical spine immobilisation, and maintenance of adequate mean 
arterial blood pressure to improve spinal cord perfusion, mechanical 
ventilation in the case of respiratory insufficiency or coma. In hospital, 
time of surgery is decided as a collegiate decision between the neurological 
surgeons and the intensivist after managing first all lifethreatening 
injuries.Weaning from mechanical ventilation must be envisaged as soon as 
possible after surgery, in the absence of any lung complication (infection, 
contusion). Ethical discussion are regularly held during ICU stay. 
Tracheotomy is frequently performed for comfort of weaning. Opportunity of 
implanting a phrenic-nerve pacemaker must be considered whenever 
possible.Weaning time goes from months to years. Early admission to spinal 
cord injury rehabilitation centres capable of managing ventilator weaning is 
therefore mandatory if aiming at early discharge from ICU.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adaptation; artificial ventilation; cervical spinal cord injury; injury; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  cardiac rhythm management device; cervical spine; coma; contusion; diaphragm; France; hospital; hospital management; human; immobilization; infection; lung complication; mean arterial pressure; nerve; patient; perfusion; phrenic nerve; quadriplegia; rehabilitation; respiratory failure; spinal cord; surgeon; surgery; tracheotomy; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70538532
DOI
  10.1016/j.rehab.2011.07.652
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2011.07.652
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770657&id=doi:10.1016%2Fj.rehab.2011.07.652&atitle=Managing+high-level+cervical+spinal+cord+injuries%3A+Intensivist%27s+point+of+view&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=54&issue=&spage=e114&epage=&aulast=Pease&aufirst=S.&auinit=S.&aufull=Pease+S.&coden=&isbn=&pages=e114-&date=2011&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 650
TITLE
  [Anterior cervical spine hyperostosis--a rare cause of difficult intubation 
in emergency].
ORIGINAL (NON-ENGLISH) TITLE
  Hiperostoza cervicalǎ anterioarǎ--o cauza rarǎ de intubaţie dificilǎ în 
urgenţǎ.
AUTHOR NAMES
  Stefan M.; Ciupilan C.; Mella C.; Scutariu M.D.
AUTHOR ADDRESSES
  (Stefan M.) Universitǎţii de Medicinǎ şi Farmacie "Gr. T. Popa" Iaşi.
(Ciupilan C.; Mella C.; Scutariu M.D.)
CORRESPONDENCE ADDRESS
  M. Stefan, Universitǎţii de Medicinǎ şi Farmacie "Gr. T. Popa" Iaşi.
FULL RECORD ENTRY DATE
  2012-03-30
SOURCE
  Revista medico-chirurgicalǎ̌ a Societǎ̌ţaii de Medici ş̧i Naturaliş̧ti din 
Iaş̧i (2011) 115:4 (1102-1106). Date of Publication: 2011 Oct-Dec
VOLUME
  115
ISSUE
  4
FIRST PAGE
  1102
LAST PAGE
  1106
DATE OF PUBLICATION
  2011 Oct-Dec
ISSN
  0048-7848
ABSTRACT
  DISH (Diffuse idiopathic skeletal hyperostosis) of cervical spine is a rare 
condition which causes dysphagia in 23% of cases and occasionally dyspnea. 
The authors report the case of a 74 years old male, known with progressive 
dysphagia and recurrent episodes of dysphonia and dyspnea, who suffered a 
sudden episode of respiratory distress that need finaly tracheotomy after 
ineffective attempts of orotracheal intubation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult respiratory distress syndrome (therapy); ankylosing hyperostosis (complication, diagnosis, therapy); cervical spine; emergency health service; endotracheal intubation (adverse drug reaction); tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; dysphagia (etiology); dysphonia (etiology); dyspnea (etiology); human; male; methodology; non insulin dependent diabetes mellitus (complication); radiography; risk factor; treatment outcome; 
LANGUAGE OF ARTICLE
  Romanian
MEDLINE PMID
  22276454 (http://www.ncbi.nlm.nih.gov/pubmed/22276454)
PUI
  L364495569
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00487848&id=doi:&atitle=%5BAnterior+cervical+spine+hyperostosis--a+rare+cause+of+difficult+intubation+in+emergency%5D.&stitle=Rev+Med+Chir+Soc+Med+Nat+Iasi&title=Revista+medico-chirurgical%C7%8E%CC%8C+a+Societ%C7%8E%CC%8C%C5%A3aii+de+Medici+%C5%9F%CC%A7i+Naturali%C5%9F%CC%A7ti+din+Ia%C5%9F%CC%A7i&volume=115&issue=4&spage=1102&epage=1106&aulast=Stefan&aufirst=Monica&auinit=M.&aufull=Stefan+M.&coden=&isbn=&pages=1102-1106&date=2011&auinit1=M&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 651
TITLE
  Original observation after a cervico-occipital disjunction: Gerhardt 
syndrome associated with Riegel syndrome
AUTHOR NAMES
  Have L.; Tell L.; Gardie Y.; Vial C.; Rode G.
AUTHOR ADDRESSES
  (Have L.) MPR, Hôpital d'instruction des arMées Desgenettes, 108 boulevard 
Pinel, Lyon, France.
(Tell L.; Rode G.) Hôpital Henry-Gabrielle, Saint-Genis-Laval, France.
(Gardie Y.) Hôpital Lyon Sud, Pierre-Bénite, France.
(Vial C.) Hôpital Neurologique, Lyon, France.
CORRESPONDENCE ADDRESS
  L. Have, MPR, Hôpital d'instruction des arMées Desgenettes, 108 boulevard 
Pinel, Lyon, France.
FULL RECORD ENTRY DATE
  2011-09-26
SOURCE
  Annals of Physical and Rehabilitation Medicine (2011) 54 SUPPL. 1 (e37). 
Date of Publication: October 2011
VOLUME
  54
FIRST PAGE
  e37
DATE OF PUBLICATION
  October 2011
CONFERENCE NAME
  26e Congres de Medecine Physique et de Readaptation
CONFERENCE LOCATION
  Nantes, France
CONFERENCE DATE
  2011-10-13 to 2011-10-15
ISSN
  1877-0657
BOOK PUBLISHER
  Elsevier Masson SAS
ABSTRACT
  Introduction.- Observations of cervico-occipital disjunction are rare. 
Short-term prognosis is poor. We report the case of a patient presenting 
cervico-occipital disjunction who achieved a favorable outcome with 
exceptional laryngeal disorders. Case report.- A 55-year-old man, with no 
medical history, presented cervicooccipital disjunction caused by a violent 
deceleration while he was driving a vehicle. He also suffered a heart 
failure. The initial assessment showed cervicooccipital dislocation with an 
epidural and prevertebral haematoma, a contusion at the bulbo-medullary 
junction and a diffuse brain oedema. He was in an intensive care unit for 2 
months. He had a tracheotomy and presented severe tetraparesis. The course 
was favorable and the tracheotomy cannula was removed. The patient was then 
referred to the rehabilitation unit. Seven days later, the patient developed 
acute laryngeal dyspnea. The fibroscopy exploration revealed a right 
Gerhardt syndrome (the vocal cord stayed permanently in a paramedian 
position) and a left Riegel syndrome (the vocal cord stayed permanently in a 
median position). Swallowing disorders is also caused by the paralysis of 
the left side of the tongue. Due to the narrowlaryngeal passage and the 
major dyspnea, a new tracheotomy was made. The electromyogram showed 
hyperactivity of the thyro-arythenoidian muscles but no denervation signs in 
abductor muscles. An injection of botulinic toxin was made in the 
arythenoidian muscles. The clinical course was favorable: standing ability, 
gripping ability, orally feeding, no dyspnea, loud and clear voice. 
Discussion.- The clinical motor recovery achieved by this patient after such 
serious trauma is exceptional. This case illustrates the importance of 
carefully monitoring the laryngeal region after a cervical spine injury due 
to the risk of swallowing and respiratory disorders. Botulinic toxin was an 
exceptional indication here: cord vocal hyperactivity. In this situation, it 
functioned as a diagnosis test, a reversible treatment and an alternative to 
the surgery.
EMTREE DRUG INDEX TERMS
  toxin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adaptation; dyspnea; 
EMTREE MEDICAL INDEX TERMS
  brain; cannula; case report; cervical spine injury; contusion; deceleration; denervation; diagnosis; disease course; dysphagia; edema; electromyogram; epidural drug administration; feeding; fiberscope endoscopy; heart failure; hematoma; human; hyperactivity; injection; injury; intensive care unit; larynx disorder; male; medical history; monitoring; muscle; paralysis; patient; prognosis; quadriplegia; rehabilitation; respiratory tract disease; risk; surgery; swallowing; tongue; tracheotomy; vocal cord; voice; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70538627
DOI
  10.1016/j.rehab.2011.07.861
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.rehab.2011.07.861
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18770657&id=doi:10.1016%2Fj.rehab.2011.07.861&atitle=Original+observation+after+a+cervico-occipital+disjunction%3A+Gerhardt+syndrome+associated+with+Riegel+syndrome&stitle=Ann.+Phys.+Rehabil.+Med.&title=Annals+of+Physical+and+Rehabilitation+Medicine&volume=54&issue=&spage=e37&epage=&aulast=Have&aufirst=L.&auinit=L.&aufull=Have+L.&coden=&isbn=&pages=e37-&date=2011&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 652
TITLE
  Facial and spinal impalement injury: An airway challenge
AUTHOR NAMES
  Gupta B.; Agrawal P.; Soni K.; D'Souza N.; Sinha S.
AUTHOR ADDRESSES
  (Gupta B.; Agrawal P., pramendraagrawal@yahoo.com; Soni K.; D'Souza N.; 
Sinha S.) Department of Anesthesia, Jai Prakash Narayan Apex Trauma Center, 
All India Institute of Medical Sciences, New Delhi, India.
CORRESPONDENCE ADDRESS
  P. Agrawal, A-148, Noida - 201 301, U.P., India. Email: 
pramendraagrawal@yahoo.com
AiP/IP ENTRY DATE
  2012-02-07
FULL RECORD ENTRY DATE
  2012-02-09
SOURCE
  Indian Journal of Critical Care Medicine (2011) 15:4 (236-237). Date of 
Publication: October-December 2011
VOLUME
  15
ISSUE
  4
FIRST PAGE
  236
LAST PAGE
  237
DATE OF PUBLICATION
  October-December 2011
ISSN
  0972-5229
  1998-359X (electronic)
BOOK PUBLISHER
  Medknow Publications and Media Pvt. Ltd, B9, Kanara Business Centre, off 
Link Road, Ghatkopar (E), Mumbai, India.
EMTREE DRUG INDEX TERMS
  fentanyl; glycopyrronium (intravenous drug administration); lidocaine; midazolam (intravenous drug administration); nitrous oxide; oxygen; sevoflurane; vecuronium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  face injury (surgery); foreign body (surgery); spine injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesia induction; artificial ventilation; body position; bone screw; case report; cervical spine; clinical feature; coughing; extubation; face edema; fascia; fiberscope endoscopy; human; laryngeal nerve; letter; liquorrhea; lung edema (complication); male; mouth cavity; nerve block; nose; odontoid process fracture; operation duration; oral surgery; penetrating trauma (surgery); postoperative care; postoperative hemorrhage (complication); premedication; radiography; respiration control; respiratory tract intubation; skull base; spine instability; spine stabilization; tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  glycopyrronium bromide (596-51-0)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  nitrous oxide (10024-97-2)
  oxygen (7782-44-7)
  sevoflurane (28523-86-6)
  vecuronium (50700-72-6)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2012063928
PUI
  L364167071
DOI
  10.4103/0972-5229.92071
FULL TEXT LINK
  http://dx.doi.org/10.4103/0972-5229.92071
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09725229&id=doi:10.4103%2F0972-5229.92071&atitle=Facial+and+spinal+impalement+injury%3A+An+airway+challenge&stitle=Indian+J.+Crit.+Care+Med.&title=Indian+Journal+of+Critical+Care+Medicine&volume=15&issue=4&spage=236&epage=237&aulast=Gupta&aufirst=Babita&auinit=B.&aufull=Gupta+B.&coden=&isbn=&pages=236-237&date=2011&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 653
TITLE
  Admission asia motor score predicting the need for tracheostomy after 
cervical spinal cord injury
AUTHOR NAMES
  Menaker J.; Stein D.; Scalea T.
AUTHOR ADDRESSES
  (Menaker J.; Stein D.; Scalea T.) R Adams Cowley Shock Trauma Center, 
Baltimore, United States.
CORRESPONDENCE ADDRESS
  J. Menaker, R Adams Cowley Shock Trauma Center, Baltimore, United States.
FULL RECORD ENTRY DATE
  2013-10-18
SOURCE
  Neurocritical Care (2011) 15:1 SUPPL. 1 (S234). Date of Publication: 
September 2011
VOLUME
  15
ISSUE
  1
FIRST PAGE
  S234
DATE OF PUBLICATION
  September 2011
CONFERENCE NAME
  9th Annual Meeting of the Neurocritical Care Society
CONFERENCE LOCATION
  Montreal, QC, Canada
CONFERENCE DATE
  2011-09-21 to 2011-09-24
ISSN
  1541-6933
BOOK PUBLISHER
  Humana Press
ABSTRACT
  Introduction Respiratory compromise and the need for tracheostomy are common 
after cervical spinal cord injury (CSCI). Recent data suggests the American 
Spinal Injury Association (ASIA) motor score strongly correlates with the 
development of organ dysfunction and failure following CSCI. The purpose of 
the study was to evaluate if ASIA motor score is associated with the need 
for tracheostomy following CSCI. Methods The trauma registry was used to 
identify all patients with isolated CSCI over a 3-year period. Patients with 
an abbreviated injury score > 3 in other body regions were excluded. Medical 
records were reviewed for demographics, admission ASIA motor score, 
anatomical level of injury, need for a tracheostomy and length of stay 
(LOS). Results 128 patients were identified. 74 patients required 
tracheostomy on mean hospital day 8.5 ( 3.5). Mean ASIA motor was 15.4 ( 
19.6). Mean anatomical level of CSCI was 4.6 ( 1.3). Comparing patients with 
and without tracheostomy, those requiring tracheostomy had significantly 
lower mean admission ASIA motor score and were more likely to be an AIS A. 
(Table 1) There was no difference in mean anatomical level of injury. Table 
2 demonstrates sensitivities, specificities, PPV and NPV for ASIA motor 
scores and the need for tracheostomy. Conclusions Tracheostomy after SCI is 
common. Lower admission ASIA motor score and “complete” injury on admission 
are significantly associated with the need for tracheostomy. Anatomical 
level of injury was not associated with tracheostomy after CSCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  American Spinal Injury Association impairment scale; cervical spinal cord injury; society; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  body regions; hospital; human; injury; length of stay; medical record; patient; register; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71193829
DOI
  10.1007/s12028-011-9625-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12028-011-9625-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15416933&id=doi:10.1007%2Fs12028-011-9625-5&atitle=Admission+asia+motor+score+predicting+the+need+for+tracheostomy+after+cervical+spinal+cord+injury&stitle=Neurocrit.+Care&title=Neurocritical+Care&volume=15&issue=1&spage=S234&epage=&aulast=Menaker&aufirst=Jay&auinit=J.&aufull=Menaker+J.&coden=&isbn=&pages=S234-&date=2011&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 654
TITLE
  Expanding the differential for autonomic dysreflexia: Mucus plugging in a 
man who is ventilator dependent and with incomplete cervical spinal cord 
injury. A case report
AUTHOR NAMES
  Feeko K.J.; Formal C.S.
AUTHOR ADDRESSES
  (Formal C.S.)
(Feeko K.J.) Thomas Jefferson University Hospital, Philadelphia, United 
States.
CORRESPONDENCE ADDRESS
  K.J. Feeko, Thomas Jefferson University Hospital, Philadelphia, United 
States.
FULL RECORD ENTRY DATE
  2011-12-20
SOURCE
  PM and R (2011) 3:10 SUPPL. 1 (S333). Date of Publication: September 2011
VOLUME
  3
ISSUE
  10
FIRST PAGE
  S333
DATE OF PUBLICATION
  September 2011
CONFERENCE NAME
  2011 Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  Orlando, FL, United States
CONFERENCE DATE
  2011-11-17 to 2011-11-20
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Patients or Programs: A 43-year-old man with incomplete ventilator-dependent 
tetraplegia. Program Description: The patient developed bradycardia with 
lightheadedness, chest discomfort, and hypoxia after routine suctioning. 
Assessment showed changes consistent with autonomic dysreflexia (AD): 
diaphoresis, flushing, and elevated systolic/diastolic blood pressure. 
Interventions, including disrobing the patient, Foley change, digital rectal 
examination, and application of 2 in. of nitroglycerin paste resulted in no 
improvement. Elevated peak inspiratory pressures were noted. Auscultation 
revealed poor air movement in the left lung. Despite removal from the 
ventilator, there was increased resistance to manual ventilation. Removal of 
the inner cannula caused a large audible air release from the tracheostomy 
tube and revealed a large mucus plug adherent to the distal lumen of the 
cannula. With a new inner cannula, aeration improved and blood pressure 
normalized. Follow-up chest x-ray film was unremarkable. Setting: A 
free-standing rehabilitation hospital. Results: AD is common after cervical 
spinal cord injury and is marked by an increased sympathetic discharge 
caused by noxious stimuli; treatment is predicated upon removal of this 
stimulus. Mucus plugging can cause complete airway obstruction, with 
resultant atelectatic change, or partial obstruction, with lung 
overdistension. This latter effect is more prevalent with mechanical 
ventilation, the presence of a tracheostomy, and with ineffective cough, 
and, therefore, is a potential cause of AD in the tetraplegic population. 
Discussion: Air trapping due to an obstructing mucus plug that creates a 
distal high pressure system with lung overinflation has previously been 
described in the asthmatic and/or chronic obstructive pulmonary population; 
however, AD due to this phenomenon has not been previously described in the 
rehabilitation setting. Conclusions: Both hypoxic events and fatal airway 
obstruction can result after bronchiolar and tracheal mucus plugs. It, 
therefore, is imperative to recognize mucus plugging as a risk factor for AD 
in the ventilator-dependent tetraplegia population.
EMTREE DRUG INDEX TERMS
  glyceryl trinitrate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autonomic dysreflexia; case report; cervical spinal cord injury; human; male; mucus; physical medicine; rehabilitation; ventilator; 
EMTREE MEDICAL INDEX TERMS
  aeration; air; airway obstruction; artificial ventilation; asthma; auscultation; blood pressure; bradycardia; cannula; coughing; diaphoresis; digital rectal examination; dizziness; follow up; hospital; hyperbarism; hypoxia; lung; manual ventilation; obstruction; paste; patient; population; quadriplegia; risk factor; stimulus; thorax pain; thorax radiography; trachea mucus; tracheostomy; tube; X ray film; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70609161
DOI
  10.1016/j.pmrj.2011.08.485
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pmrj.2011.08.485
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:10.1016%2Fj.pmrj.2011.08.485&atitle=Expanding+the+differential+for+autonomic+dysreflexia%3A+Mucus+plugging+in+a+man+who+is+ventilator+dependent+and+with+incomplete+cervical+spinal+cord+injury.+A+case+report&stitle=PM+R&title=PM+and+R&volume=3&issue=10&spage=S333&epage=&aulast=Formal&aufirst=Christopher+S.&auinit=C.S.&aufull=Formal+C.S.&coden=&isbn=&pages=S333-&date=2011&auinit1=C&auinitm=S
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 655
TITLE
  Caesarean delivery and exit procedure for the management of a large fetal 
nasopharyngeal teratoma under combined spinal epidural anaesthesia
AUTHOR NAMES
  Alfoudri H.; Mlechkova L.; Almatrook D.
AUTHOR ADDRESSES
  (Alfoudri H.; Mlechkova L.; Almatrook D.) United Kingdom.
(Alfoudri H.; Mlechkova L.; Almatrook D.) Kuwait.
CORRESPONDENCE ADDRESS
  H. Alfoudri, United Kingdom.
FULL RECORD ENTRY DATE
  2012-05-11
SOURCE
  Regional Anesthesia and Pain Medicine (2011) 36:5 SUPPL. 2 (E191). Date of 
Publication: September-October 2011
VOLUME
  36
ISSUE
  5
FIRST PAGE
  E191
DATE OF PUBLICATION
  September-October 2011
CONFERENCE NAME
  30th Annual European Society of Regional Anaesthesia, ESRA Congress 2011
CONFERENCE LOCATION
  Dresden, Germany
CONFERENCE DATE
  2011-09-07 to 2011-09-10
ISSN
  1098-7339
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: A number of case reports have been published in the litreture 
describing the use of an EXIT (EX Utero Intrapartum Treatment) procedure 
during cesarean section (CS). The EXIT procedure involves partial delivery 
of the fetus where its upper half is exteriorised while the torso remains in 
the uterus with an intact placenta allowing fetal surgery to be performed. 
Most EXIT procedures are performed under deep general anaesthesia (GA) which 
allows uterine relaxation through inhalational agents. However, we report 
this case of an EXIT procedure performed sucessfully under combined spinal 
epidural anaesthesia (CSE). Method and Results: A 33 years old pregnant 
woman presented for an elective CS and an EXIT procedure to manage a large 
fetal orofacial mass. The procedure was performed under CSE which was 
achieved with 2.5mls intrathecal 0.5%heavy bupivacaine with 25mcg fentanyl 
and an epidural catheter sited to allow further topups. a dense neuroaxial 
blockade was established reaching T4 dermatome. Delivery of the fetal head 
and thorax was achieved through a Pfannenstiel incision. Intravenous (IV) 
nitroglycerin was not required as the uterus was sufficienty relaxed. 
Examination of the baby revealed a large 10×10cm mass protruding from the 
mouth. The fetal airway was secured with a tracheostomy and a live female 
was delivered and the CS was completed successfully without need for 
epidural topups. Conclusions: We suggest that a CSE can be considered for an 
EXIT procedure in order to avoid the known risks associated with GA in the 
obstetric population.
EMTREE DRUG INDEX TERMS
  bupivacaine; fentanyl; glyceryl trinitrate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidural anesthesia; procedures; regional anesthesia; society; teratoma; 
EMTREE MEDICAL INDEX TERMS
  airway; baby; case report; cesarean section; dermatome; epidural catheter; epidural drug administration; examination; female; fetus; fetus surgery; general anesthesia; human; incision; inhalational drug administration; intrathecal drug administration; placenta; population; pregnant woman; risk; thorax; tracheostomy; trunk; uterus; uterus relaxation; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70735755
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10987339&id=doi:&atitle=Caesarean+delivery+and+exit+procedure+for+the+management+of+a+large+fetal+nasopharyngeal+teratoma+under+combined+spinal+epidural+anaesthesia&stitle=Reg.+Anesth.+Pain+Med.&title=Regional+Anesthesia+and+Pain+Medicine&volume=36&issue=5&spage=E191&epage=&aulast=Alfoudri&aufirst=H.&auinit=H.&aufull=Alfoudri+H.&coden=&isbn=&pages=E191-&date=2011&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 656
TITLE
  Dysphagia in cervical spinal cord injury
AUTHOR NAMES
  Shin J.C.; Yoo J.H.; Lee Y.S.; Goo H.R.; Kim D.H.
AUTHOR ADDRESSES
  (Shin J.C.; Yoo J.H.; Lee Y.S., youngsang_lee@hanmail.net; Goo H.R.; Kim 
D.H.) Department and Research Institute of Rehabilitation Medicine, Yonsei 
University College of Medicine, 134 Shinchong-dong, Seodaemun-gu, Seoul 
120-752, South Korea.
(Yoo J.H.) Department of Rehabilitation Medicine, Inje University College of 
Medicine, Ilsan Paik Hospital, Goyang, South Korea.
CORRESPONDENCE ADDRESS
  Y.S. Lee, Department and Research Institute of Rehabilitation Medicine, 
Yonsei University College of Medicine, 134 Shinchong-dong, Seodaemun-gu, 
Seoul 120-752, South Korea. Email: youngsang_lee@hanmail.net
AiP/IP ENTRY DATE
  2011-05-19
FULL RECORD ENTRY DATE
  2011-09-15
SOURCE
  Spinal Cord (2011) 49:9 (1008-1013). Date of Publication: September 2011
VOLUME
  49
ISSUE
  9
FIRST PAGE
  1008
LAST PAGE
  1013
DATE OF PUBLICATION
  September 2011
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design:Retrospective chart review of cervical spinal cord injury 
patients, who underwent videofluoroscopic swallowing study 
(VFSS).Objectives:To evaluate the swallowing function of cervical spinal 
cord injury patients, analyze the features of dysphagia and investigate 
their association with the clinical symptoms and signs.Setting:Spinal Cord 
Injury Unit, Yonsei Rehabilitation Hospital, Seoul, 
Korea.Methods:Retrospective study (1 May 2001-31 May 2008) on inpatients 
with tetraplegia. All enrolled patients underwent VFSS, and their results 
were correlated with clinical data including symptoms and signs indicative 
of dysphagia.Results:A total of 121 cervical spinal cord injury patients 
(106 male and 16 female patients) were included in this study. Ten patients 
showed evidence of aspiration on VFSS. Statistical correlation to aspiration 
was found with age, presence of tracheostomy, and symptoms and signs 
indicating dysphagia. However, out of the 10 patients with evident 
aspiration, 2 patients did not show any symptoms or signs indicating 
aspiration.Conclusion: Because of the possibility of silent aspiration, we 
recommend that physicians treating patients with cervical spinal cord injury 
should always take the possibility of dysphagia and silent aspiration into 
consideration, especially in case of previous manifestation of pneumonia, 
presence of tracheostomy, or presence of signs and symptoms indicating 
dysphagia. © 2011 International Spinal Cord Society. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (etiology); dysphagia (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; asymptomatic disease (complication, diagnosis); child; clinical feature; controlled study; correlation analysis; female; fluoroscopy; groups by age; hospital patient; human; major clinical study; male; priority journal; pulmonary aspiration (complication, diagnosis); retrospective study; risk factor; school child; South Korea; swallowing; tracheostomy; videorecording; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011492023
MEDLINE PMID
  21577216 (http://www.ncbi.nlm.nih.gov/pubmed/21577216)
PUI
  L51427494
DOI
  10.1038/sc.2011.34
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2011.34
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2011.34&atitle=Dysphagia+in+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=49&issue=9&spage=1008&epage=1013&aulast=Shin&aufirst=J.C.&auinit=J.C.&aufull=Shin+J.C.&coden=SPCOF&isbn=&pages=1008-1013&date=2011&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 657
TITLE
  Complications of tracheostomy after anterior cervical spine fixation surgery
AUTHOR NAMES
  Romero-Ganuza J.; Gambarrutta C.; Merlo-Gonzalez V.E.; Marin-Ruiz M.A.; Diez De La Lastra-Buigues E.; Oliviero A.
AUTHOR ADDRESSES
  (Romero-Ganuza J., fjromero@sescam.jccm.es; Merlo-Gonzalez V.E.; Marin-Ruiz 
M.A.; Diez De La Lastra-Buigues E.) Intensive Care Unit, Service of Internal 
Medicine, Toledo, Spain.
(Gambarrutta C.) Pneumology Unit, Service of Internal Medicine, Toledo, 
Spain.
(Oliviero A.) Neurology Section, Paraplegics National Hospital, Toledo, 
Spain.
CORRESPONDENCE ADDRESS
  J. Romero-Ganuza, Intensive Care Unit, Hospital Nacional de Parapléjicos, 
Finca La Peraleda s/n, Toledo 45071, Spain. Email: fjromero@sescam.jccm.es
AiP/IP ENTRY DATE
  2011-03-25
FULL RECORD ENTRY DATE
  2011-09-09
SOURCE
  American Journal of Otolaryngology - Head and Neck Medicine and Surgery 
(2011) 32:5 (408-411). Date of Publication: September-October 2011
VOLUME
  32
ISSUE
  5
FIRST PAGE
  408
LAST PAGE
  411
DATE OF PUBLICATION
  September-October 2011
ISSN
  0196-0709
  1532-818X (electronic)
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Purpose: Cervical traumatic spinal cord-injured patients often way require 
both anterior cervical spine stabilization and tracheostomy in the first few 
days after the injury. The infectious complication of tracheostomy can 
interfere with the evolution of the fixation surgery. The aim of our study 
was to evaluate the safety of tracheostomy performed early after anterior 
cervical spine stabilization. Materials and methods: We reviewed the 
clinical records of 28 patients admitted to our hospital intensive care 
unit. In all cases, percutaneous tracheostomy was performed using the 
percutaneous dilation technique. Results: The average time interval between 
the fixation surgery and tracheostomy was 8.25 ± 5.57 days. We had 
complications in tracheostomy in only 3 cases: minor bleeding occurred in 1 
patient and stomal infection, not propagated to the fixation surgery wound, 
was observed in 2 patients. Two patients died without causal relation to 
these interventions. Conclusions: The early performance of tracheostomy 
after cervical spinal fixation surgery is safe, still realized early and 
nearly this, at least if the tracheostomy is performed by percutaneous 
method. © 2011 Elsevier Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  postoperative complication (complication); spine stabilization; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; bleeding (complication); clinical article; female; human; male; medical record review; methicillin resistant Staphylococcus aureus infection (complication); priority journal; respiratory failure (complication); retrospective study; spinal cord injury; spine fracture; stoma infection (complication); surgical infection (complication); 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011478210
MEDLINE PMID
  21439682 (http://www.ncbi.nlm.nih.gov/pubmed/21439682)
PUI
  L51331518
DOI
  10.1016/j.amjoto.2010.07.020
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.amjoto.2010.07.020
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01960709&id=doi:10.1016%2Fj.amjoto.2010.07.020&atitle=Complications+of+tracheostomy+after+anterior+cervical+spine+fixation+surgery&stitle=Am.+J.+Otolaryngol.+Head+Neck+Med.+Surg.&title=American+Journal+of+Otolaryngology+-+Head+and+Neck+Medicine+and+Surgery&volume=32&issue=5&spage=408&epage=411&aulast=Romero-Ganuza&aufirst=Javier&auinit=J.&aufull=Romero-Ganuza+J.&coden=AJOTD&isbn=&pages=408-411&date=2011&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 658
TITLE
  Outcomes after total aortic arch replacement with right axillary artery 
cannulation and a presewn multibranched graft
AUTHOR NAMES
  Kulik A.; Castner C.F.; Kouchoukos N.T.
AUTHOR ADDRESSES
  (Castner C.F.; Kouchoukos N.T., ntkouch@aol.com) Division of Cardiovascular 
and Thoracic Surgery, Missouri Baptist Medical Center, St. Louis, MO, United 
States.
(Kulik A.) Lynn Heart and Vascular Institute, Boca Raton Regional Hospital, 
Boca Raton, FL, United States.
(Kulik A.) Charles E. Schmidt College of Medicine, Florida Atlantic 
University, Boca Raton, FL, United States.
CORRESPONDENCE ADDRESS
  N.T. Kouchoukos, Cardiac, Thoracic, and Vascular Surgery, 3009 N Ballas Rd, 
Ste 360C, St. Louis, MO, 63131, United States. Email: ntkouch@aol.com
AiP/IP ENTRY DATE
  2011-09-22
FULL RECORD ENTRY DATE
  2011-09-29
SOURCE
  Annals of Thoracic Surgery (2011) 92:3 (889-897). Date of Publication: 
September 2011
VOLUME
  92
ISSUE
  3
FIRST PAGE
  889
LAST PAGE
  897
DATE OF PUBLICATION
  September 2011
ISSN
  0003-4975
  1552-6259 (electronic)
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background: Several techniques are available for aortic arch replacement. We 
evaluated our experience with total aortic arch replacement using a presewn 
multibranched graft and right axillary artery cannulation for brain 
perfusion. Methods: Between 2002 and 2010, 88 patients (mean age, 61.5 ± 
14.6 years) underwent total aortic arch replacement by midline sternotomy 
(27 patients) or bilateral anterior thoracotomy (61 patients). During a 
brief period of deep hypothermic circulatory arrest (DHCA) (mean duration, 
11.0 ± 7.8 minutes), the brachiocephalic arteries were detached from the 
aorta and clamped. Cerebral perfusion through the right axillary artery was 
then initiated while the arteries were sequentially attached to the branches 
of the presewn graft (mean duration: 40.4 ± 9.8 minutes). The ascending 
aorta and entire arch were replaced in all patients, combined with varying 
lengths of the descending aorta. Results: The 30-day mortality rate was 
5.7%. Stroke occurred in 3.4%, spinal cord ischemic injury in 3.4% (1 
paraplegia, 2 paraparesis), and new-onset renal failure requiring dialysis 
in 3.4% of patients. The 5-year survival rate was 70.7% ± 5.5%. All graft 
branches remained patent during imaging follow-up (mean duration, 2.6 ± 2.2 
years). Six patients required reoperation on the graft or contiguous aorta 
after the initial repair, but no reoperations were required on the aortic 
arch or its branches. The 5-year rate of freedom from reoperation was 90.4% 
± 4.0%. Conclusions: The use of a presewn multibranched graft and 
hypothermic brain perfusion through the right axillary artery is a safe 
method for replacement of the aortic arch, resulting in a low incidence of 
neurologic complications and favorable durability and patency. © 2011 The 
Society of Thoracic Surgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic arch surgery; artery catheterization; artery graft; axillary artery; brain perfusion; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; artificial heart pacemaker; artificial ventilation; ascending aorta; atrial fibrillation (complication); blindness (complication); blood transfusion; brachiocephalic trunk; cerebrospinal fluid drainage; cerebrovascular accident (complication); deep hypothermic circulatory arrest; deep vein thrombosis (complication); descending aorta; dialysis; follow up; graft patency; human; kidney failure (complication, therapy); lung embolism (complication); major clinical study; neurologic disease (complication); optic nerve injury (complication); outcome assessment; paraplegia (complication, therapy); pneumonia (complication); priority journal; reoperation; spinal cord injury (complication); sternotomy; surgical infection (complication); surgical mortality; survival rate; thoracotomy; tracheostomy; vocal cord paralysis (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011516934
MEDLINE PMID
  21871274 (http://www.ncbi.nlm.nih.gov/pubmed/21871274)
PUI
  L362558820
DOI
  10.1016/j.athoracsur.2011.04.067
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2011.04.067
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2Fj.athoracsur.2011.04.067&atitle=Outcomes+after+total+aortic+arch+replacement+with+right+axillary+artery+cannulation+and+a+presewn+multibranched+graft&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=92&issue=3&spage=889&epage=897&aulast=Castner&aufirst=Catherine+F.&auinit=C.F.&aufull=Castner+C.F.&coden=ATHSA&isbn=&pages=889-897&date=2011&auinit1=C&auinitm=F
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 659
TITLE
  Severe airway distress following cervical spine operation: Retrospective 
breakdown of the chain of errors
ORIGINAL (NON-ENGLISH) TITLE
  Dramatischer Atemwegsnotfall nach Operation an der Halswirbelsäule: 
Retrospektive Analyse der Fehlerkette
AUTHOR NAMES
  Paul C.; Ladra A.; Pillai V.; Böttiger B.W.; Spöhr F.; Keller K.; Zarghooni K.
AUTHOR ADDRESSES
  (Paul C., christian.paul@stadt-koeln.de) Institut für Notfallmedizin, 
Berufsfeuerwehr Stadt Köln, Scheibenstr. 13, Köln 50737, Germany.
(Ladra A.) Abteilung für Anästhesiologie, Marien-Hospital, Erftstadt, 
Germany.
(Pillai V.; Böttiger B.W.; Spöhr F.) Klinik für Anästhesiologie und 
Operative Intensivmedizin, Universitätsklinik Köln, Köln, Germany.
(Keller K.; Zarghooni K.) Klinik und Poliklinik für Orthopädie und 
Unfallchirurgie, Universitätsklinik Köln, Köln, Germany.
CORRESPONDENCE ADDRESS
  C. Paul, Institut für Notfallmedizin, Berufsfeuerwehr Stadt Köln, 
Scheibenstr. 13, Köln 50737, Germany. Email: christian.paul@stadt-koeln.de
AiP/IP ENTRY DATE
  2011-07-07
FULL RECORD ENTRY DATE
  2011-10-28
SOURCE
  Anaesthesist (2011) 60:9 (845-849). Date of Publication: September 2011
VOLUME
  60
ISSUE
  9
FIRST PAGE
  845
LAST PAGE
  849
DATE OF PUBLICATION
  September 2011
ISSN
  0003-2417
  1432-055X (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  A 71-year-old female patient received a prothesis due to a cervical disc 
prolapsed and bleeding into the collar soft tissues occurred 
postoperatively. Following a computed tomography examination severe peracute 
respiratory decompensation occurred while administering topical anesthesia 
to the pharynx in order to perform fiber optic intubation. Endotracheal 
intubation using conventional laryngoscopy was unsuccessful and the patient 
required immediate cricothyroidotomy. As an on-site cricothyrotomy set to 
establish a secure airway was not available the decision was taken to 
perform surgical cricothyroidotomy. As a conclusion to this life-threatening 
event in the case of symptoms, such as dyspnea, dysphonia and dysphagia 
after operations of the cervical spine the airway has to be secured early 
and according to the local algorithm. © 2011 Springer-Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory distress (complication); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; cervical disk hernia; computer assisted tomography; female; human; intervertebral disk hernia; laryngoscopy; postoperative hemorrhage (complication); topical anesthesia; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  2011576315
MEDLINE PMID
  21728049 (http://www.ncbi.nlm.nih.gov/pubmed/21728049)
PUI
  L51507893
DOI
  10.1007/s00101-011-1914-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00101-011-1914-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032417&id=doi:10.1007%2Fs00101-011-1914-z&atitle=Severe+airway+distress+following+cervical+spine+operation%3A+Retrospective+breakdown+of+the+chain+of+errors&stitle=Anaesthesist&title=Anaesthesist&volume=60&issue=9&spage=845&epage=849&aulast=Paul&aufirst=C.&auinit=C.&aufull=Paul+C.&coden=ANATA&isbn=&pages=845-849&date=2011&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 660
TITLE
  Endoscopic image-guided transcervical odontoidectomy: Outcomes of 15 
patients with basilar invagination
AUTHOR NAMES
  Dasenbrock H.H.; Clarke M.J.; Ali Bydon M.D.; Sciubba D.M.; Witham T.F.; Gokaslan Z.L.; Wolinsky J.-P.
AUTHOR ADDRESSES
  (Dasenbrock H.H.; Clarke M.J.; Ali Bydon M.D.; Sciubba D.M.; Witham T.F.; 
Gokaslan Z.L.; Wolinsky J.-P.)
CORRESPONDENCE ADDRESS
  H. H. Dasenbrock,
AiP/IP ENTRY DATE
  2011-08-17
SOURCE
  Neurosurgery (2011). Date of Publication: 5 Aug 2011
DATE OF PUBLICATION
  5 Aug 2011
ISSN
  0148-396X
ABSTRACT
  BACKGROUND: Ventral decompression with posterior stabilization is the 
preferred treatment for symptomatic irreducible basilar invagination (BI). 
Endoscopic image-guided transcervical odontoidectomy (ETO) may allow for 
decompression with limited morbidity. OBJECTIVE: To describe the 
peri-operative outcomes of patients undergoing anterior decompression of 
basilar invagination using ETO. METHODS: 15 patients who had a follow-up of 
at least 16 months were retrospectively reviewed. Intra-operatively, the 
vertebral body of C2 was removed and the odontoid was resected in a 
"top-down" manner using endoscopic visualization and frameless stereotactic 
navigation. Posterior instrumented stabilization was subsequently performed. 
RESULTS: The average (±standard deviation) age of the patients was 42.6±24.5 
(range 11-72) years. Post-operative complications occurred in 6 patients, 
including a urinary tract infection (n=2), upper airway swelling (n=2), 
dysphagia (n=2), gastrostomy tube placement (n=1), and an asymptomatic 
pseudomeningocele (n=1). No patients required a tracheostomy, had bacterial 
meningitis, or developed a venous thromboembolic event; only one patient was 
intubated for more than 48 hours post-operatively. With a mean follow-up of 
41.9±14.4 (range 16-59) months, myelopathy improved in all patients and no 
patient experienced late neurologic deterioration. The mean modified 
Japanese Orthopedic Association (JOA) score increased from 11.2±4.2 to 
15.9±1.4 (P=0.002). Patients with a diagnosis other than rheumatoid 
arthritis or who had a higher pre-operative JOA score had a significantly 
better post-operative neurological recovery (P=0.005). CONCLUSION: ETO may 
be a valid treatment for patients with symptomatic irreducible basilar 
invagination that avoids some of the morbidity of transoral surgery and 
leads to long-term improvement in myelopathy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  human; invagination; patient; 
EMTREE MEDICAL INDEX TERMS
  bacterial meningitis; decompression; deterioration; diagnosis; dysphagia; follow up; frameless stereotactic procedure; Japanese (people); morbidity; odontoid process; postoperative complication; rheumatoid arthritis; spinal cord disease; stomach tube; surgery; swelling; thromboembolism; tracheostomy; upper respiratory tract; urinary tract infection; vertebra body; 
MEDLINE PMID
  21826033 (http://www.ncbi.nlm.nih.gov/pubmed/21826033)
PUI
  L51564957
DOI
  10.1227/NEU.0b013e318230e59a
FULL TEXT LINK
  http://dx.doi.org/10.1227/NEU.0b013e318230e59a
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0148396X&id=doi:10.1227%2FNEU.0b013e318230e59a&atitle=Endoscopic+image-guided+transcervical+odontoidectomy%3A+Outcomes+of+15+patients+with+basilar+invagination&stitle=Neurosurgery&title=Neurosurgery&volume=&issue=&spage=&epage=&aulast=Dasenbrock&aufirst=Hormuzdiyar+H.&auinit=H.H.&aufull=Dasenbrock+H.H.&coden=NRSRD&isbn=&pages=-&date=2011&auinit1=H&auinitm=H
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 661
TITLE
  A systematic review of intensive cardiopulmonary management after spinal 
cord injury
AUTHOR NAMES
  Casha S.; Christie S.
AUTHOR ADDRESSES
  (Casha S., scasha@dal.ca; Christie S.) Division of Neurosurgery, Dalhousie 
University, Halifax, NS, Canada.
CORRESPONDENCE ADDRESS
  S. Casha, QEII Health Sciences Centre, Halifax Infirmary, 1796 Summer 
Street, Halifax, NS B3H 3A7, Canada. Email: scasha@dal.ca
AiP/IP ENTRY DATE
  2011-08-03
FULL RECORD ENTRY DATE
  2011-08-05
SOURCE
  Journal of Neurotrauma (2011) 28:8 (1479-1495). Date of Publication: 1 Aug 
2011
VOLUME
  28
ISSUE
  8
FIRST PAGE
  1479
LAST PAGE
  1495
DATE OF PUBLICATION
  1 Aug 2011
ISSN
  0897-7151
  1557-9042 (electronic)
BOOK PUBLISHER
  Mary Ann Liebert Inc., 140 Huguenot Street, New Rochelle, United States.
ABSTRACT
  Intensive cardiopulmonary management is frequently undertaken in patients 
with spinal cord injury (SCI), particularly due to the occurrence of 
neurogenic shock and ventilatory insufficiency and in an attempt to reduce 
secondary injury. We undertook a systematic review of the literature to 
examine the evidence that intensive care management improves outcome after 
SCI and to attempt to define key parameters for cardiopulmonary 
support/resuscitation. We review the literature in five areas: management of 
SCI patients in specialized centers, risk in SCI patients of cardiopulmonary 
complications, parameters for blood pressure and oxygenation/ventilation 
support following SCI, risk factors for cardiopulmonary insufficiency 
requiring ICU care after SCI, and preventative strategies to reduce the 
risks of cardiopulmonary complications in SCI patients. The literature 
supports that, in light of the significant incidence of cardiorespiratory 
complications, SCI patients should be managed in a monitored special care 
unit. There is weak evidence supporting the maintenance of MAP >85 mmHg for 
a period extending up to 1 week following SCI. © 2011 Mary Ann Liebert, Inc.
EMTREE DRUG INDEX TERMS
  atropine; dexamethasone; dextran; dihydroergotoxine mesilate; dobutamine; dopamine; hypertensive agent; inotropic agent; methylprednisolone; noradrenalin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cardiopulmonary hemodynamics; intensive care; spinal cord injury (surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  apnea (complication); areflexia (complication); artificial ventilation; aspiration pneumonia (complication); atelectasis (complication); atelectasis (complication); bladder function; blood gas analysis; blood transfusion; breathing exercise; breathing rate; cardiopulmonary function; cardiopulmonary insufficiency; cardiovascular risk; colloid; disease association; disease severity; electromyography; fluid therapy; follow up; forced vital capacity; heart arrest (complication); heart arrhythmia (complication); heart atrium pacemaker; hospital admission; hospital care; hospital discharge; hospitalization; human; hypotension (complication, therapy); hypoxia; immobilization; injury severity; length of stay; life expectancy; lung edema; lung embolism (complication); lung function test; lung infection (complication); lung insufficiency; lung ventilation; mean arterial pressure; morbidity; mortality; muscle strength; neurologic examination; oxygenation; paraplegia; peak expiratory flow; pneumonia (complication); positive end expiratory pressure; prognosis; quadriplegia; reoperation; respiratory failure (complication); respiratory function; respiratory tract disease; resuscitation; retrospective study; review; risk factor; spirometry; systematic review; systolic blood pressure; thorax radiography; tidal volume; total lung capacity; tracheobronchial toilet; tracheotomy; treatment outcome; vascular resistance; vital capacity; 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  dexamethasone (50-02-2)
  dextran (87915-38-6, 9014-78-2)
  dihydroergotoxine mesilate (8067-24-1)
  dobutamine (34368-04-2, 49745-95-1, 52663-81-7, 61661-06-1)
  dopamine (51-61-6, 62-31-7)
  methylprednisolone (6923-42-8, 83-43-2)
  noradrenalin (1407-84-7, 51-41-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011410767
MEDLINE PMID
  20030558 (http://www.ncbi.nlm.nih.gov/pubmed/20030558)
PUI
  L362216736
DOI
  10.1089/neu.2009.1156
FULL TEXT LINK
  http://dx.doi.org/10.1089/neu.2009.1156
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08977151&id=doi:10.1089%2Fneu.2009.1156&atitle=A+systematic+review+of+intensive+cardiopulmonary+management+after+spinal+cord+injury&stitle=J.+Neurotrauma&title=Journal+of+Neurotrauma&volume=28&issue=8&spage=1479&epage=1495&aulast=Casha&aufirst=Steven&auinit=S.&aufull=Casha+S.&coden=JNEUE&isbn=&pages=1479-1495&date=2011&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 662
TITLE
  Pre-Hospital care management of a potential spinal cord injured patient: A 
systematic review of the literature and evidence-based guidelines
AUTHOR NAMES
  Ahn H.; Singh J.; Nathens A.; MacDonald R.D.; Travers A.; Tallon J.; Fehlings M.G.; Yee A.
AUTHOR ADDRESSES
  (Ahn H.; Fehlings M.G.; Yee A., Albert.yee@sunnybrook.ca) Department of 
Surgery, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N3M5, 
Canada.
(Singh J.) Department of Interdepartmental Medicine, Division of Critical 
Care, University of Toronto, Toronto, ON, Canada.
(Nathens A.) Department of Surgery, Health Policy, Management and 
Evaluation, University of Toronto, Toronto, ON, Canada.
(MacDonald R.D.) Department of Research and Development, Division of 
Emergency Medicine, University of Toronto, Toronto, ON, Canada.
(Travers A.) Department of Emergency Medicine, Dalhousie University, 
Halifax, NS, Canada.
(Tallon J.) Department of Emergency Medicine, Surgery and Community Health 
and Epidemiology, Dalhousie University, Halifax, NS, Canada.
CORRESPONDENCE ADDRESS
  A. Yee, Department of Surgery, University of Toronto, 2075 Bayview Avenue, 
Toronto, ON M4N3M5, Canada. Email: Albert.yee@sunnybrook.ca
AiP/IP ENTRY DATE
  2011-08-03
FULL RECORD ENTRY DATE
  2011-08-05
SOURCE
  Journal of Neurotrauma (2011) 28:8 (1341-1361). Date of Publication: 1 Aug 
2011
VOLUME
  28
ISSUE
  8
FIRST PAGE
  1341
LAST PAGE
  1361
DATE OF PUBLICATION
  1 Aug 2011
ISSN
  0897-7151
  1557-9042 (electronic)
BOOK PUBLISHER
  Mary Ann Liebert Inc., 140 Huguenot Street, New Rochelle, United States.
ABSTRACT
  An interdisciplinary expert panel of medical and surgical specialists 
involved in the management of patients with potential spinal cord injuries 
(SCI) was assembled. Four key questions were created that were of 
significant interest. These were: (1) what is the optimal type and duration 
of pre-hospital spinal immobilization in patients with acute SCI?; (2) 
during airway manipulation in the pre-hospital setting, what is the ideal 
method of spinal immobilization?; (3) what is the impact of pre-hospital 
transport time to definitive care on the outcomes of patients with acute 
spinal cord injury?; and (4) what is the role of pre-hospital care providers 
in cervical spine clearance and immobilization? A systematic review 
utilizing multiple databases was performed to determine the current evidence 
about the specific questions, and each article was independently reviewed 
and assessed by two reviewers based on inclusion and exclusion criteria. 
Guidelines were then created related to the questions by a national Canadian 
expert panel using the Delphi method for reviewing the evidence-based 
guidelines about each question. Recommendations about the key questions 
included: the pre-hospital immobilization of patients using a cervical 
collar, head immobilization, and a spinal board; utilization of padded 
boards or inflatable bean bag boards to reduce pressure; transfer of 
patients off of spine boards as soon as feasible, including transfer of 
patients off spinal boards while awaiting transfer from one hospital 
institution to another hospital center for definitive care; inclusion of 
manual in-line cervical spine traction for airway management in patients 
requiring intubation in the pre-hospital setting; transport of patients with 
acute traumatic SCI to the definitive hospital center for care within 24h of 
injury; and training of emergency medical personnel in the pre-hospital 
setting to apply criteria to clear patients of cervical spinal injuries, and 
immobilize patients suspected of having cervical spinal injury. © 2011 Mary 
Ann Liebert, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hospital care; pre hospital care; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  air medical transport; athlete; autoregulation; cervical spine; clinical assessment; clinical effectiveness; consciousness level; crossover procedure; emergency care; endotracheal intubation; flexor reflex; fluoroscopy; fracture immobilization; fracture treatment; gunshot injury; head immobilization; health care facility; health care personnel; health care quality; health service; human; immobilization; injury severity; intracranial pressure; medical education; mortality; multicenter study (topic); nasotracheal intubation; neck pain; neuroimaging; neurologic examination; orthosis; pain assessment; patient assessment; patient care; patient information; patient referral; patient transport; positive end expiratory pressure; range of motion; respiration control; review; sacrum; spine fracture; spine immobilization; splinting; stretcher; supine position; systematic review; thoracolumbar spine; thorax pressure; tracheostomy; transcutaneous carbon dioxide monitoring; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011410769
MEDLINE PMID
  20175667 (http://www.ncbi.nlm.nih.gov/pubmed/20175667)
PUI
  L362216738
DOI
  10.1089/neu.2009.1168
FULL TEXT LINK
  http://dx.doi.org/10.1089/neu.2009.1168
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08977151&id=doi:10.1089%2Fneu.2009.1168&atitle=Pre-Hospital+care+management+of+a+potential+spinal+cord+injured+patient%3A+A+systematic+review+of+the+literature+and+evidence-based+guidelines&stitle=J.+Neurotrauma&title=Journal+of+Neurotrauma&volume=28&issue=8&spage=1341&epage=1361&aulast=Ahn&aufirst=Henry&auinit=H.&aufull=Ahn+H.&coden=JNEUE&isbn=&pages=1341-1361&date=2011&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 663
TITLE
  Acute management of nutritional demands after spinal cord injury
AUTHOR NAMES
  Thibault-Halman G.; Casha S.; Singer S.; Christie S.
AUTHOR ADDRESSES
  (Thibault-Halman G.) Division of Neurosurgery, Capital District Health 
Authority, Halifax Infirmary, Halifax, NS, Canada.
(Casha S.; Christie S., sean.christie@dal.ca) Division of Neurosurgery, 
Dalhousie University, 3814-1796 Summer Street, Halifax, NS B3H 3A7, Canada.
(Singer S.) Division of Food and Nutrition Services, Capital District Health 
Authority, Halifax Infirmary, Halifax, NS, Canada.
CORRESPONDENCE ADDRESS
  S. Christie, Division of Neurosurgery, Dalhousie University, 3814-1796 
Summer Street, Halifax, NS B3H 3A7, Canada. Email: sean.christie@dal.ca
AiP/IP ENTRY DATE
  2011-08-03
FULL RECORD ENTRY DATE
  2011-08-05
SOURCE
  Journal of Neurotrauma (2011) 28:8 (1497-1507). Date of Publication: 1 Aug 
2011
VOLUME
  28
ISSUE
  8
FIRST PAGE
  1497
LAST PAGE
  1507
DATE OF PUBLICATION
  1 Aug 2011
ISSN
  0897-7151
  1557-9042 (electronic)
BOOK PUBLISHER
  Mary Ann Liebert Inc., 140 Huguenot Street, New Rochelle, United States.
ABSTRACT
  A systematic review of the literature was performed to address pertinent 
clinical questions regarding nutritional management in the setting of acute 
spinal cord injury (SCI). Specific metabolic challenges are present 
following spinal cord injury. The acute stage is characterized by a 
reduction in metabolic activity, as well as a negative nitrogen balance that 
cannot be corrected, even with aggressive nutritional support. Metabolic 
demands need to be accurately monitored to avoid overfeeding. Enteral 
feeding is the optimal route following SCI. When oral feeding is not 
possible, nasogastric, followed by nasojejunal, then by percutaneous 
endoscopic gastrostomy, if necessary, is suggested. © 2011 Mary Ann Liebert, 
Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  nutritional support; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  anorexia (complication); aspiration; bacteriuria (complication); body weight loss; calorimetry; decubitus (complication); dysgeusia (complication); dysosmia (complication); dysphagia; energy expenditure; enteric feeding; human; jejunostomy; length of stay; malabsorption (complication); metabolism; nitrogen balance; nose feeding; nutritional assessment; nutritional status; paraplegia; percutaneous endoscopic gastrostomy; pleurisy (complication); pneumonia (complication); quadriplegia; review; septicemia (complication); spinal cord transsection; surgical infection (complication); systematic review; total parenteral nutrition; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Clinical and Experimental Biochemistry (29)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011410781
MEDLINE PMID
  20373845 (http://www.ncbi.nlm.nih.gov/pubmed/20373845)
PUI
  L362216750
DOI
  10.1089/neu.2009.1155
FULL TEXT LINK
  http://dx.doi.org/10.1089/neu.2009.1155
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08977151&id=doi:10.1089%2Fneu.2009.1155&atitle=Acute+management+of+nutritional+demands+after+spinal+cord+injury&stitle=J.+Neurotrauma&title=Journal+of+Neurotrauma&volume=28&issue=8&spage=1497&epage=1507&aulast=Thibault-Halman&aufirst=Ginette&auinit=G.&aufull=Thibault-Halman+G.&coden=JNEUE&isbn=&pages=1497-1507&date=2011&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 664
TITLE
  A clinical description of extubation failure in patients with primary brain 
injury
AUTHOR NAMES
  Karanjia N.; Nordquist D.; Stevens R.; Nyquist P.
AUTHOR ADDRESSES
  (Karanjia N.; Stevens R.; Nyquist P., pnyquis1@jhmi.edu) Neurocritical Care 
Division, Neurology, Anesthesia/Critical Care Medicine, Neurosurgery, Johns 
Hopkins School of Medicine, 600 N Wolfe Street, Meyer 8-140, Baltimore, MD 
21287, United States.
(Nordquist D.) Department of Medicine, Westchester Medical Center, Valhalla, 
NY, United States.
CORRESPONDENCE ADDRESS
  P. Nyquist, Neurocritical Care Division, Neurology, Anesthesia/Critical Care 
Medicine, Neurosurgery, Johns Hopkins School of Medicine, 600 N Wolfe 
Street, Meyer 8-140, Baltimore, MD 21287, United States. Email: 
pnyquis1@jhmi.edu
AiP/IP ENTRY DATE
  2011-09-19
FULL RECORD ENTRY DATE
  2011-09-26
SOURCE
  Neurocritical Care (2011) 15:1 (4-12). Date of Publication: August 2011
VOLUME
  15
ISSUE
  1
FIRST PAGE
  4
LAST PAGE
  12
DATE OF PUBLICATION
  August 2011
ISSN
  1541-6933
  1556-0961 (electronic)
BOOK PUBLISHER
  Humana Press, 999 Riverview Drive, Suite 208, Totowa, United States.
ABSTRACT
  Background Patients with acute brain injury but normal lung function are 
often intubated for airway protection, but extubation often fails. 
Currently, no clinical data exist that describe the events leading to 
extubation failure in this population. We examined the extubation failure 
rate, reintubation rate, and clinical characteristics of patients whose 
reason for intubation was a primary neurological injury. We then identified 
the clinical characteristics of those patients with primary brain injury who 
were reintubated. Methods We conducted a retrospective review of patients 
admitted to the neurocritical care unit of a tertiary care hospital from 
January 2002 to March 2007. Results Of 1,265 patients who were intubated 
because of primary neurological injury of brain, spinal cord, or peripheral 
nerve, 25 (2%) died before extubation and 767 (61%) were successfully 
extubated. Tracheostomies were placed in 181 (14%) patients, of which, 77 
(6.1%) were completed before a trial of extubation and 104 (8.2%) after 
extubation failure. A total of 129 (10%) patients were reintubated; 77 
(6.1%) were reintubated within 72 h, meeting the definition of extubation 
failure. The other 52 (4.1%) were intubated after 72 h usually in the 
setting of pneumonia or decreased mental status. Ninety-nine of the patients 
reintubated had primary brain injury and resulting encephalopathy. All were 
successfully reintubated. Most patients intubated as a result of a primary 
brain injury (981) were successfully extubated. The most common clinical 
scenario leading to reintubation in these encephalopathic patients was 
respiratory distress associated with altered mental status [59 patients 
(59%)]. These patients usually had atelectasis and decreased minute 
ventilation, independent of fever, pneumonia, aspiration, and increased work 
of breathing [39 patients (39%)]. Conclusion The extubation failure rate in 
our neurocritical care unit is low. In patients with encephalopathy and 
primary brain injury who were reintubated, respiratory distress caused by 
altered mental status was the most common cause of reintubation. These 
patients demonstrated signs disrupted ventilation usually with periods of 
prolonged hypoventilation. Increased work of breathing from lung injury due 
to pneumonia or aspiration was not the most common cause of reintubation in 
this population. © Springer Science+Business Media, LLC 2011.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; extubation; treatment failure; 
EMTREE MEDICAL INDEX TERMS
  aspiration; atelectasis; brain disease; breathing rate; clinical evaluation; disease association; fever; human; intensive care unit; intubation; lung minute volume; major clinical study; mental deficiency; mental health; neurologic disease; outcome assessment; peripheral nerve injury; pneumonia; priority journal; respiratory distress; retreatment; retrospective study; review; spinal cord disease; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011504893
MEDLINE PMID
  21394542 (http://www.ncbi.nlm.nih.gov/pubmed/21394542)
PUI
  L51314811
DOI
  10.1007/s12028-011-9528-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12028-011-9528-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15416933&id=doi:10.1007%2Fs12028-011-9528-5&atitle=A+clinical+description+of+extubation+failure+in+patients+with+primary+brain+injury&stitle=Neurocrit.+Care&title=Neurocritical+Care&volume=15&issue=1&spage=4&epage=12&aulast=Karanjia&aufirst=Navaz&auinit=N.&aufull=Karanjia+N.&coden=&isbn=&pages=4-12&date=2011&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 665
TITLE
  Herpes simplex encephalitis following spinal ependymoma resection: Case 
report and literature review
AUTHOR NAMES
  Raper D.M.S.; Wong A.; McCormick P.C.; Lewis L.D.
AUTHOR ADDRESSES
  (Raper D.M.S., drap7157@uni.sydney.edu.au) Graduate Medical Program, 
University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, 
Australia.
(Wong A.) College of Physicians and Surgeons, Columbia University, New York, 
NY, United States.
(McCormick P.C.) Department of Neurological Surgery, Columbia University, 
New York, NY, United States.
(Lewis L.D.) Department of Neurology, Columbia University, New York, NY, 
United States.
CORRESPONDENCE ADDRESS
  D. M. S. Raper, Graduate Medical Program, University of Sydney, Royal North 
Shore Hospital, St Leonards, NSW 2065, Australia. Email: 
drap7157@uni.sydney.edu.au
AiP/IP ENTRY DATE
  2010-10-15
FULL RECORD ENTRY DATE
  2011-07-21
SOURCE
  Journal of Neuro-Oncology (2011) 103:3 (771-776). Date of Publication: July 
2011
VOLUME
  103
ISSUE
  3
FIRST PAGE
  771
LAST PAGE
  776
DATE OF PUBLICATION
  July 2011
ISSN
  0167-594X
  1573-7373 (electronic)
BOOK PUBLISHER
  Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, 
United States.
ABSTRACT
  Herpes simplex encephalitis (HSE) is a rare complication of neurosurgical 
procedures but must be considered in early deterioration of the 
postoperative patient. This is the first report of HSE following spinal cord 
tumor resection. A 65-year-old woman had C2-C5 laminectomy for subtotal 
resection of intramedullary ependymoma. Six days postoperatively she 
developed fever, vomiting and rapid decline in mental status. Brain MRI 
revealed enhancement of left insular cortex. Polymerase chain reaction on 
cerebrospinal fluid (CSF) identified herpes simplex virus type 1 (HSV-1) as 
the causal agent. Twenty-one days of acyclovir led to improvement. Three 
subsequent admissions to neurological intensive care unit were required for 
deterioration in mental status, including pneumonia, hydrocephalus and deep 
vein thromboses. Ventriculoperitoneal shunt (VPS), tracheotomy, percutaneous 
intravenous central catheter (PICC) line and percutaneous endoscopic 
gastrostomy (PEG) were placed. She was discharged to skilled nursing home 
care. Acyclovir is effective therapy against HSV, though outcomes may be 
poor even in optimally treated cases. Empiric treatment must be started even 
in the absence of serologic evidence of HSV infection if suspicion for HSE 
is high. © 2010 Springer Science+Business Media, LLC.
EMTREE DRUG INDEX TERMS
  aciclovir (drug therapy, intravenous drug administration); cefepime (drug therapy); dexamethasone (drug therapy); piperacillin plus tazobactam (drug therapy); vancomycin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ependymoma (drug therapy, drug therapy, surgery); herpes simplex encephalitis (drug therapy, complication, diagnosis, drug 
therapy); laminectomy; spine ependymoma (drug therapy, drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; article; brain ventricle peritoneum shunt; case report; central venous catheterization; cerebrospinal fluid analysis; deep vein thrombosis (complication); female; fever; hospital admission; hospital discharge; human; Human alphaherpesvirus 1; hydrocephalus (complication, surgery); intensive care unit; Klebsiella; medical literature; meningitis (complication, drug therapy); mental deterioration; nuclear magnetic resonance imaging; nursing home; percutaneous endoscopic gastrostomy; pneumonia (complication); polymerase chain reaction; postoperative period; Proteus; tracheotomy; treatment duration; treatment outcome; urosepsis (complication, drug therapy); virus identification; vomiting; 
CAS REGISTRY NUMBERS
  aciclovir (59277-89-3)
  cefepime (88040-23-7)
  dexamethasone (50-02-2)
  vancomycin (1404-90-6, 1404-93-9)
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011359360
MEDLINE PMID
  20941525 (http://www.ncbi.nlm.nih.gov/pubmed/20941525)
PUI
  L51108641
DOI
  10.1007/s11060-010-0438-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s11060-010-0438-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0167594X&id=doi:10.1007%2Fs11060-010-0438-8&atitle=Herpes+simplex+encephalitis+following+spinal+ependymoma+resection%3A+Case+report+and+literature+review&stitle=J.+Neuro-Oncol.&title=Journal+of+Neuro-Oncology&volume=103&issue=3&spage=771&epage=776&aulast=Raper&aufirst=Daniel+M.+S.&auinit=D.M.S.&aufull=Raper+D.M.S.&coden=JNODD&isbn=&pages=771-776&date=2011&auinit1=D&auinitm=M.S.
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 666
TITLE
  Occipitocervicothoracic stabilization in pediatric patients: Clinical 
article
AUTHOR NAMES
  Fargen K.M.; Anderson R.C.E.; Harter D.H.; Angevine P.D.; Coon V.C.; Brockmeyer D.L.; Pincus D.W.
AUTHOR ADDRESSES
  (Fargen K.M., kyle.fargen@neurosurgery.ufl.edu; Pincus D.W.) Department of 
Neurosurgery, University of Florida, College of Medicine, Gainesville, FL, 
United States.
(Anderson R.C.E.; Angevine P.D.) Department of Neurological Surgery, 
Columbia University, United States.
(Harter D.H.) Department of Neurosurgery, New York University, School of 
Medicine, New York, NY, United States.
(Coon V.C.; Brockmeyer D.L.) Department of Neurosurgery, University of Utah, 
School of Medicine, Salt Lake City, UT, United States.
CORRESPONDENCE ADDRESS
  K. M. Fargen, Department of Neurosurgery, University of Florida, College of 
Medicine, Gainesville, FL, United States. Email: 
kyle.fargen@neurosurgery.ufl.edu
AiP/IP ENTRY DATE
  2011-07-20
FULL RECORD ENTRY DATE
  2011-07-22
SOURCE
  Journal of Neurosurgery: Pediatrics (2011) 8:1 (57-62). Date of Publication: 
July 2011
VOLUME
  8
ISSUE
  1
FIRST PAGE
  57
LAST PAGE
  62
DATE OF PUBLICATION
  July 2011
ISSN
  1933-0707
  1933-0715 (electronic)
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Object. Although rarely encountered, pediatric patients with severe cervical 
spine deformities and instability may occasionally require 
occipitocervicothoracic instrumentation and fusion. This case series reports 
the experience of 4 pediatric centers in managing this condition. 
Occipitocervical fixation is the treatment of choice for craniocervical 
instability that is symptomatic or threatens neurological function. In 
children, the most common distal fixation level with modern techniques is 
C-2. Treated patients maintain a significant amount of neck motion due to 
the flexibility of the subaxial cervical spine. Distal fixation to the 
thoracic spine has been reported in adult case series. This procedure is to 
be avoided due to the morbidity of complete loss of head and neck motion. 
Unfortunately, in rare cases, the pathological condition or highly aberrant 
anatomy may require occipitocervical constructs to include the thoracic 
spine. Methods. The authors identified 13 patients who underwent 
occipitocervicothoracic fixation. Demographic, radiological, and clinical 
data were gathered through retrospective review of patient records from 4 
institutions. Results. Patients ranged from 1 to 14 years of age. There were 
7 girls and 6 boys. Diagnoses included Klippel-Feil, Larsen, Morquio, and 
VATER syndromes as well as postlaminectomy kyphosis and severe skeletal 
dysplasia. Four patients were neurologically intact and 9 had myelopathy. 
Five children were treated with preoperative traction prior to 
instrumentation; 5 underwent both anterior and posterior spinal 
reconstruction. Two patients underwent instrumentation beyond the thoracic 
spine. Allograft was used anteriorly, and autologous rib grafts were used in 
the majority for posterior arthrodesis. Follow-up ranged from 0 to 43 
months. Computed tomography confirmed fusion in 9 patients; the remaining 
patients were lost to follow-up or had not undergone repeat imaging at the 
time of writing. Patients with myelopathy either improved or stabilized. One 
child had mild postoperative unilateral upper-extremity weakness, and a 
second child died due to a tracheostomy infection. All patients had severe 
movement restriction as expected. Conclusions. Occipitocervicothoracic 
stabilization may be employed to stabilize and reconstruct complex pediatric 
spinal deformities. Neurological function can be maintained or improved. The 
long-term morbidity of loss of cervical motion remains to be elucidated.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  occipitocervicothoracic fixation; spine stabilization; 
EMTREE MEDICAL INDEX TERMS
  adolescent; arm weakness; arthrodesis; article; bone dysplasia; cervical spine; child; clinical article; computer assisted tomography; craniocervical instability; female; follow up; human; infant; Jarcho Levin syndrome (diagnosis, surgery); Klippel Feil syndrome (surgery); kyphosis; male; morbidity; Morquio syndrome (surgery); preschool child; priority journal; rib graft; school child; spinal cord disease; spine instability; syndrome VATER (surgery); thoracic spine; tracheostomy; traction therapy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011384036
MEDLINE PMID
  21721890 (http://www.ncbi.nlm.nih.gov/pubmed/21721890)
PUI
  L362127232
DOI
  10.3171/2011.4.PEDS10450
FULL TEXT LINK
  http://dx.doi.org/10.3171/2011.4.PEDS10450
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19330707&id=doi:10.3171%2F2011.4.PEDS10450&atitle=Occipitocervicothoracic+stabilization+in+pediatric+patients%3A+Clinical+article&stitle=J.+Neursurg.+Pediatr.&title=Journal+of+Neurosurgery%3A+Pediatrics&volume=8&issue=1&spage=57&epage=62&aulast=Fargen&aufirst=Kyle+M.&auinit=K.M.&aufull=Fargen+K.M.&coden=&isbn=&pages=57-62&date=2011&auinit1=K&auinitm=M
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 667
TITLE
  Vascularized free fibula for cervical spine reconstruction following 
complicated retropharyngeal abscess
AUTHOR NAMES
  Moche J.A.; Chopra K.; Gastman B.
AUTHOR ADDRESSES
  (Moche J.A.; Chopra K.) University of Maryland School of Medicine, 
Baltimore, MD, United States.
(Moche J.A.) Department of Otorhinolaryngology, University of Maryland 
School of Medicine, Baltimore, MD, United States.
(Gastman B., GastmaB@ccf.org) Dermatology and Plastic Surgery Institute, 
Head and Neck Institute, Columbia University, New York, NY, United States.
CORRESPONDENCE ADDRESS
  B. Gastman, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United 
States. Email: GastmaB@ccf.org
AiP/IP ENTRY DATE
  2012-04-03
FULL RECORD ENTRY DATE
  2012-04-06
SOURCE
  Otolaryngology - Head and Neck Surgery (2011) 145:1 (178-179). Date of 
Publication: July 2011
VOLUME
  145
ISSUE
  1
FIRST PAGE
  178
LAST PAGE
  179
DATE OF PUBLICATION
  July 2011
ISSN
  0194-5998
  1097-6817 (electronic)
BOOK PUBLISHER
  SAGE Publications Inc., 2455 Teller Road, Thousand Oaks, United States.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy, intravenous drug administration); titanium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fibula graft; retropharyngeal abscess (drug therapy, complication, drug therapy); spine surgery; vertebral corpectomy; 
EMTREE MEDICAL INDEX TERMS
  adult; anastomosis; article; bone plate; case report; cervical spine injury (surgery); computer assisted tomography; contrast enhancement; dysphagia; human; implant; laryngoscopy; leukocyte count; male; neck pain; neurosurgery; osteomyelitis (surgery); paresthesia; postoperative period; tooth extraction; tracheostomy; treatment outcome; weakness; 
CAS REGISTRY NUMBERS
  titanium (7440-32-6)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2012178035
MEDLINE PMID
  21493342 (http://www.ncbi.nlm.nih.gov/pubmed/21493342)
PUI
  L364512443
DOI
  10.1177/0194599811398193
FULL TEXT LINK
  http://dx.doi.org/10.1177/0194599811398193
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01945998&id=doi:10.1177%2F0194599811398193&atitle=Vascularized+free+fibula+for+cervical+spine+reconstruction+following+complicated+retropharyngeal+abscess&stitle=Otolaryngol.+Head+Neck+Surg.&title=Otolaryngology+-+Head+and+Neck+Surgery&volume=145&issue=1&spage=178&epage=179&aulast=Moche&aufirst=Jason+A.&auinit=J.A.&aufull=Moche+J.A.&coden=OTOLD&isbn=&pages=178-179&date=2011&auinit1=J&auinitm=A
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 668
TITLE
  Distal embolic brain infarction due to recanalization of asymptomatic 
vertebral artery occlusion resulting from cervical spine injury: Case report
AUTHOR NAMES
  Nakao Y.; Moridaira H.; Suda K.; Kajino T.; Tojo Y.; Ueda H.; Kokabu T.
AUTHOR ADDRESSES
  (Nakao Y.; Moridaira H.; Suda K.; Kajino T.; Tojo Y.; Ueda H.; Kokabu T.) 
Spinal Cord Injury Center, Hokkaido Chuo Rosai Hospital, Japan.
CORRESPONDENCE ADDRESS
  Y. Nakao, Spinal Cord Injury Center, Hokkaido Chuo Rosai Hospital, Japan.
FULL RECORD ENTRY DATE
  2012-04-26
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2011) 16 (78). Date of 
Publication: June 2011
VOLUME
  16
FIRST PAGE
  78
DATE OF PUBLICATION
  June 2011
CONFERENCE NAME
  2011 International Congress on Spinal Cord Medicine and Rehabilitation
CONFERENCE LOCATION
  Washington, DC, United States
CONFERENCE DATE
  2011-06-04 to 2011-06-08
ISSN
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc.
ABSTRACT
  Objective: Spinal injuries are frequently associated with vertebral artery 
occlusion (VAO). Many aspects of the management of VAO remain controversial, 
including the screening criteria, the diagnostic modality, and the optimal 
treatment for various lesions. We present a case of brain infarction due to 
recanalization of the occluded VA following open reduction of cervical 
spinal dislocation and discuss the management of VAO. Design: A case report. 
Participants/methods: A 41-yearold man presented with C4-5 
distractive-flexion injury manifesting with quadriplegia and anesthesia 
below the C3 cord level (including phrenic nerve paralysis) and 
bowel-bladder dysfunction. MR angiography and CT angiography showed left 
extracranial VA (V2) occlusion and patent contralateral VA. He was observed 
without antiplatelet and/or anticoagulation therapy and underwent surgery 
(open reduction and internal fusion of C4/5, and tracheostomy) 8 hours after 
the injury. Results: After surgery, supraspinal symptoms such as left 
horizontal nystagmus and left homonymous hemianopsia led to cranial CT and 
MRI, which showed left-side cerebellar infarction in the posterior inferior 
cerebellar artery (PICA) territory and rightside posterior cerebral artery 
(PCA) infarction. MR angiography and CT angiography demonstrated patent 
bilateral VA (but hypoplastic right VA) and occluded right PCA (P2). He was 
treated with observation alone without any other ischemic complications. 
Conclusion: In this case, VA occlusion on the dominant side caused by 
cervical spinal dislocation led to cerebellar infarction in the PICA 
territory due to hemodynamic compromise or arterial dissection. 
Contralateral PCA infarction was caused by artery-to-artery embolization 
originated from recanalized VA. The management of asymptomatic VAO is 
controversial with several treatment options available, including 
observation alone, antiplatelet therapy, anticoagulation therapy, or 
invasive intervention. Although there are some reports described that 
management with observation alone seems safe, we should pay serious 
attention to the VA injury caused by cervical spine trauma.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain infarction; case report; cervical spine injury; recanalization; rehabilitation; spinal cord; vertebral artery stenosis; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; anticoagulant therapy; artery; artery dissection; artificial embolization; bladder dysfunction; cerebellum infarction; cerebral artery disease; cervical spine dislocation; computed tomographic angiography; diagnosis; homonymous hemianopia; human; infarction; injury; intestine; magnetic resonance angiography; male; nerve paralysis; nuclear magnetic resonance imaging; nystagmus; occlusion; open reduction (procedure); patent; phrenic nerve; posterior inferior cerebellar artery; quadriplegia; screening; spine injury; surgery; therapy; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70724466
DOI
  10.1310/sci16S1-53
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci16S1-53
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci16S1-53&atitle=Distal+embolic+brain+infarction+due+to+recanalization+of+asymptomatic+vertebral+artery+occlusion+resulting+from+cervical+spine+injury%3A+Case+report&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=16&issue=&spage=78&epage=&aulast=Nakao&aufirst=Y.&auinit=Y.&aufull=Nakao+Y.&coden=&isbn=&pages=78-&date=2011&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 669
TITLE
  Late complications of intrathecal baclofen pump management
AUTHOR NAMES
  Oleson C.V.
AUTHOR ADDRESSES
  (Oleson C.V.) Department of Physical Medicine/Rehabilitation, University of 
Alabama at Birmingham, Birmingham, United States.
CORRESPONDENCE ADDRESS
  C.V. Oleson, Department of Physical Medicine/Rehabilitation, University of 
Alabama at Birmingham, Birmingham, United States.
FULL RECORD ENTRY DATE
  2012-04-26
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2011) 16 (100-101). Date of 
Publication: June 2011
VOLUME
  16
FIRST PAGE
  100
LAST PAGE
  101
DATE OF PUBLICATION
  June 2011
CONFERENCE NAME
  2011 International Congress on Spinal Cord Medicine and Rehabilitation
CONFERENCE LOCATION
  Washington, DC, United States
CONFERENCE DATE
  2011-06-04 to 2011-06-08
ISSN
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc.
ABSTRACT
  Objectives: To explore late complications of intrathecal baclofen (ITB) pump 
usage, leading to ultimate explantation of the pump; and to explore reasons 
for elective discontinuation of the pump in subjects with long term ITB use. 
Design: Retrospective chart review. Participants/methods: 205 charts were 
screened to identify 67 eligible subjects with ITB pump >8 years and 
diagnoses of spinal cord injury, anoxic or traumatic brain injury, stroke, 
multiple sclerosis, or hereditary forms of spastic paraplegia. Independent 
variables included diagnosis causing spasticity, eventual daily ITB rate, 
age, years with pump, and living situation. The above factors were examined 
as a function of complication type and incidence and of rate of voluntary 
pump. Tests of significance (P & .05) were performed on each of the 
variables. Results: Complications leading to pump explantation were not 
associated with daily rates ITB (in mcg), years with pump independent of 
subject's overall health status, or subject's age. There was a significantly 
higher number of infections leading to pump removal in persons with SCI 
relative to other diagnostic groups, especially in SCI subjects with 
tracheostomy, pressure ulcers, or recurrent urinary tract infections. 
Independent of diagnostic group, those living in chronic long- term care 
centers (nursing or group homes) were at significantly higher rates of pump 
explantation for medical, financial, and social reasons. Conclusion: 
Complications with ITB such as infections and pump dislodgement/spontaneous 
explantation were observed more often in persons with urinary tract 
infections, osteomyelitis and pressure ulcers, and chronic tracheostomy and 
in those residing in chronic care facilities. In addition to high infection 
risk, those living in a nursing home face financial and logistical 
challenges in maintaining the pump, sometimes leading to voluntary 
discontinuation.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  baclofen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intrathecal drug administration; pump; rehabilitation; spinal cord; 
EMTREE MEDICAL INDEX TERMS
  cerebrovascular accident; decubitus; diagnosis; diagnosis related group; explant; health status; human; independent variable; infection; infection risk; long term care; medical record review; multiple sclerosis; nursing; nursing home; osteomyelitis; residential home; spastic paraplegia; spasticity; spinal cord injury; tracheostomy; traumatic brain injury; urinary tract infection; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70724514
DOI
  10.1310/sci16S1-53
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci16S1-53
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci16S1-53&atitle=Late+complications+of+intrathecal+baclofen+pump+management&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=16&issue=&spage=100&epage=101&aulast=Oleson&aufirst=Christina+V.&auinit=C.V.&aufull=Oleson+C.V.&coden=&isbn=&pages=100-101&date=2011&auinit1=C&auinitm=V
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 670
TITLE
  An autopsy case of familial amyotrophic lateral sclerosis with an Arg146Cys 
mutation in Cu/Zn superoxide dismutase
AUTHOR NAMES
  Hayashi K.; Koide R.; Honma T.; Mochizuki Y.; Kawata A.; Mizutani T.
AUTHOR ADDRESSES
  (Hayashi K.; Koide R.; Kawata A.) Dept. of Neurol., Tokyo Met. Neurol. 
Hosp., Japan.
(Mochizuki Y.; Mizutani T.) Dept. of Pathol., Tokyo Met. Neurol. Hosp., 
Japan.
(Honma T.) Dept. of Pathol., Nihon Univ., Sch. of Med., Japan.
CORRESPONDENCE ADDRESS
  K. Hayashi, Dept. of Neurol., Tokyo Met. Neurol. Hosp., Japan.
FULL RECORD ENTRY DATE
  2012-03-23
SOURCE
  Neuropathology (2011) 31:3 (327). Date of Publication: June 2011
VOLUME
  31
ISSUE
  3
FIRST PAGE
  327
DATE OF PUBLICATION
  June 2011
CONFERENCE NAME
  52nd Annual Meeting of the Japanese Society of Neuropathology
CONFERENCE LOCATION
  Kyoto, Japan
CONFERENCE DATE
  2011-06-02 to 2011-06-04
ISSN
  0919-6544
BOOK PUBLISHER
  Wiley Blackwell
ABSTRACT
  A 58-year-old man developed hoarseness. He underwent tracheostomy and 
percutaneous endoscopic gastrostomy at age of 59 because of his severe 
bulbar palsy and respiratory failure. Three months later, orthostatic 
hypotension and urination disorder occurred. Generalized muscle weakness and 
external opthalmoplegia progressed to absent all of his voluntary movement 
(totally locked-in state). He died of pneumonia at age of 68. He had a 
family history with ALS (sister and cousin). The brain weighted 1,200 g. The 
spinal cord and the brainstem showed severe atrophy. Neuron loss of the 
motor nuclei in the brainstem and the spinal cord, fiber loss of the 
coritccospinal tract and Betz cell's loss were marked. Furthermore, 
degeneration extended motor neurons, such as the Clarke's nucleus, posterior 
columns, spinocerebellar tract, intermediolateral nucleus, globus pallidus, 
subthalamic nucleus, substantia nigra, and thalamus were observed. This 
patient had neuronal loss of nucleus of the vagus nerve, solitaly tract 
nucleus and intermediolateral nucleus, besides the feature of FALS and TLS.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  superoxide dismutase; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis; autopsy; Japanese (people); mutation; neuropathology; society; 
EMTREE MEDICAL INDEX TERMS
  atrophy; brain; brain stem; bulbar paralysis; cell loss; degeneration; family history; fiber; globus pallidus; hoarseness; human; male; micturition disorder; motoneuron; motoneuron nucleus; muscle weakness; nerve cell; orthostatic hypotension; patient; percutaneous endoscopic gastrostomy; pneumonia; pyramidal nerve cell; respiratory failure; spinal cord; spinocerebellar tract; substantia nigra; subthalamic nucleus; thalamus; tracheostomy; vagus nerve; voluntary movement; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70692734
DOI
  10.1111/j.1440-1789.2010.01226.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1440-1789.2010.01226.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:10.1111%2Fj.1440-1789.2010.01226.x&atitle=An+autopsy+case+of+familial+amyotrophic+lateral+sclerosis+with+an+Arg146Cys+mutation+in+Cu%2FZn+superoxide+dismutase&stitle=Neuropathology&title=Neuropathology&volume=31&issue=3&spage=327&epage=&aulast=Hayashi&aufirst=K.&auinit=K.&aufull=Hayashi+K.&coden=&isbn=&pages=327-&date=2011&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 671
TITLE
  Controlateral cavernous syndrome, brainstem congestion and posterior fossa 
venous thrombosis with cerebellar hematoma related to a ruptured 
intracavernous carotid artery aneurysm
AUTHOR NAMES
  Aldea S.; Guedin P.; Roccatagliata L.; Boulin A.; Auliac S.; Dupuy M.; Cerf C.; Gaillard S.; Rodesch G.
AUTHOR ADDRESSES
  (Aldea S., s.aldea@hopital-foch.org; Dupuy M.; Gaillard S.) Department of 
Neurosurgery, Hopital Foch, Suresnes, France.
(Guedin P.; Roccatagliata L.; Boulin A.; Auliac S.; Rodesch G.) Department 
of Neuroradiology, Hopital Foch, Suresnes, France.
(Cerf C.) Department of Intensive Care, Hopital Foch, Suresnes, France.
(Aldea S., s.aldea@hopital-foch.org) Service de Neurochirurgie, Hopital 
Foch, 40 rue Worth, Suresnes 92151, France.
CORRESPONDENCE ADDRESS
  S. Aldea, Service de Neurochirurgie, Hopital Foch, 40 rue Worth, Suresnes 
92151, France. Email: s.aldea@hopital-foch.org
AiP/IP ENTRY DATE
  2011-03-09
FULL RECORD ENTRY DATE
  2011-07-25
SOURCE
  Acta Neurochirurgica (2011) 153:6 (1297-1302). Date of Publication: June 
2011
VOLUME
  153
ISSUE
  6
FIRST PAGE
  1297
LAST PAGE
  1302
DATE OF PUBLICATION
  June 2011
ISSN
  0001-6268
  0942-0940 (electronic)
BOOK PUBLISHER
  Springer Wien, Sachsenplatz 4-6, P.O. Box 89, Vienna, Austria.
ABSTRACT
  Intracavernous carotid artery aneurysms (ICCAs) are rarely associated with 
life-threatening complications. We describe a 55-year-old woman who, after 
the rupture of an intracavernous carotid artery aneurysm, presented with a 
contralateral cavernous sinus syndrome and severe posterior fossa and spinal 
cord symptoms. Following parent artery occlusion, thrombosis of the 
posterior fossa and spinal cord veins caused a progressive worsening of the 
neurological status to a "locked-in" state. The patient fully recovered with 
anticoagulation therapy. Comprehension of the pathophysiological mechanism 
associated with the rupture of ICCA and early diagnosis of the related 
symptoms are essential in order to plan a correct treatment that includes 
the management of the aneurysm rupture and of possible complications related 
to venous thrombosis. © 2011 Springer-Verlag.
EMTREE DRUG INDEX TERMS
  anticoagulant agent (drug therapy, intravenous drug administration); fluindione (drug therapy, oral drug administration); heparin (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm rupture (complication, diagnosis); brain edema (diagnosis); brain hematoma (complication, diagnosis, surgery); cavernous sinus thrombosis (drug therapy, diagnosis, drug therapy); internal carotid artery aneurysm (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  abducens nerve paralysis (diagnosis, therapy); adult; anticoagulant therapy; article; brain angiography; carotid artery bruit (complication); carotid artery obstruction; carotid cavernous fistula (complication); case report; clinical feature; computer assisted tomography; confusion (complication); craniectomy; diplopia (complication); disease association; disease exacerbation; disease severity; dysarthria (complication); dysphagia (surgery); early diagnosis; exophthalmos (complication, therapy); facial nerve paralysis (diagnosis); female; follow up; functional status; gait disorder (complication); Glasgow coma scale; headache (complication); human; locked in syndrome (complication); magnetic resonance angiography; mydriasis; neuroimaging; nuclear magnetic resonance imaging; paraplegia (complication, diagnosis); posterior fossa; priority journal; tracheostomy; 
CAS REGISTRY NUMBERS
  fluindione (957-56-2)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011347725
MEDLINE PMID
  21380852 (http://www.ncbi.nlm.nih.gov/pubmed/21380852)
PUI
  L51308125
DOI
  10.1007/s00701-011-0982-9
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00701-011-0982-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016268&id=doi:10.1007%2Fs00701-011-0982-9&atitle=Controlateral+cavernous+syndrome%2C+brainstem+congestion+and+posterior+fossa+venous+thrombosis+with+cerebellar+hematoma+related+to+a+ruptured+intracavernous+carotid+artery+aneurysm&stitle=Acta+Neurochir.&title=Acta+Neurochirurgica&volume=153&issue=6&spage=1297&epage=1302&aulast=Aldea&aufirst=Sorin&auinit=S.&aufull=Aldea+S.&coden=ACNUA&isbn=&pages=1297-1302&date=2011&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 672
TITLE
  A critical review of recombinant human bone morphogenetic protein-2 trials 
in spinal surgery: Emerging safety concerns and lessons learned
AUTHOR NAMES
  Carragee E.J.; Hurwitz E.L.; Weiner B.K.
AUTHOR ADDRESSES
  (Carragee E.J., carragee@stanford.edu) Department of Orthopedic Surgery, 
Stanford University, Mail Code 6342, 450 Broadway, Redwood City, CA 94063, 
United States.
(Hurwitz E.L.) Office of Public Health, University of Hawaii, 1960 East-West 
Rd, Honolulu, HI, United States.
(Weiner B.K.) Department of Orthopaedic Surgery, Methodist Hospital, 6565 
Fannin St, Houston, TX, United States.
CORRESPONDENCE ADDRESS
  E.J. Carragee, Department of Orthopedic Surgery, Stanford University, Mail 
Code 6342, 450 Broadway, Redwood City, CA 94063, United States. Email: 
carragee@stanford.edu
AiP/IP ENTRY DATE
  2011-07-13
FULL RECORD ENTRY DATE
  2011-07-18
SOURCE
  Spine Journal (2011) 11:6 (471-491). Date of Publication: June 2011
VOLUME
  11
ISSUE
  6
FIRST PAGE
  471
LAST PAGE
  491
DATE OF PUBLICATION
  June 2011
ISSN
  1529-9430
  1878-1632 (electronic)
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Background context: Increasingly, reports of frequent and occasionally 
catastrophic complications associated with use of recombinant human bone 
morphogenetic protein-2 (rhBMP-2) in spinal fusion surgeries are being 
published. In the original peer review, industry-sponsored publications 
describing the use of rhBMP-2 in spinal fusion, adverse events of these 
types and frequency were either not reported at all or not reported to be 
associated with rhBMP-2 use. Some authors and investigators have suggested 
that these discrepancies were related to inadequate peer review and 
editorial oversight. Purpose: To compare the conclusions regarding the 
safety and related efficacy published in the original rhBMP-2 
industry-sponsored trials with subsequently available Food and Drug 
Administration (FDA) data summaries, follow-up publications, and 
administrative and organizational databases. Study design: Systematic 
review. Methods: Results and conclusions from original industry-sponsored 
rhBMP-2 publications regarding safety and related efficacy were compared 
with available FDA data summaries, follow-up publications, and 
administrative and organizational database analyses. Results: There were 13 
original industry-sponsored rhBMP-2 publications regarding safety and 
efficacy, including reports and analyses of 780 patients receiving rhBMP-2 
within prospective controlled study protocols. No rhBMP-2-associated adverse 
events (0%) were reported in any of these studies (99% confidence interval 
of adverse event rate <0.5%). The study designs of the industry-sponsored 
rhBMP-2 trials for use in posterolateral fusions and posterior lateral 
interbody fusion were found to have potential methodological bias against 
the control group. The reported morbidity of iliac crest donor site pain was 
also found to have serious potential design bias. Comparative review of FDA 
documents and subsequent publications revealed originally unpublished 
adverse events and internal inconsistencies. From this review, we suggest an 
estimate of adverse events associated with rhBMP-2 use in spine fusion 
ranging from 10% to 50% depending on approach. Anterior cervical fusion with 
rhBMP-2 has an estimated 40% greater risk of adverse events with rhBMP-2 in 
the early postoperative period, including life-threatening events. After 
anterior interbody lumbar fusion rates of implant displacement, subsidence, 
infection, urogenital events, and retrograde ejaculation were higher after 
using rhBMP-2 than controls. Posterior lumbar interbody fusion use was 
associated with radiculitis, ectopic bone formation, osteolysis, and poorer 
global outcomes. In posterolateral fusions, the risk of adverse effects 
associated with rhBMP-2 use was equivalent to or greater than that of iliac 
crest bone graft harvesting, and 15% to 20% of subjects reported early back 
pain and leg pain adverse events; higher doses of rhBMP-2 were also 
associated with a greater apparent risk of new malignancy. Conclusions: 
Level I and Level II evidence from original FDA summaries, original 
published data, and subsequent studies suggest possible study design bias in 
the original trials, as well as a clear increased risk of complications and 
adverse events to patients receiving rhBMP-2 in spinal fusion. This risk of 
adverse events associated with rhBMP-2 is 10 to 50 times the original 
estimates reported in the industry-sponsored peer-reviewed publications. © 
2011 Elsevier Inc. All rights reserved.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  recombinant bone morphogenetic protein 2 (adverse drug reaction); 
EMTREE DRUG INDEX TERMS
  antibiotic agent; antiinflammatory agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical discectomy; anterior interbody lumbar fusion; cervical spine anterior fusion; posterior lateral interbody fusion; posterior lumbar interbody fusion; posterolateral lumbar interbody fusion; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  arthrodesis; assisted ventilation; autograft; backache (side effect); bladder disease (side effect); bone disease (side effect); bone graft; bone pain (complication); bone radiography; breathing disorder (side effect); cancer risk; carcinogenicity; data base; disease association; drug efficacy; drug megadose; drug safety; dysphagia (side effect); ectopic bone formation; Food and Drug Administration; human; iliac crest; iliac crest bone graft; infection (side effect); inflammation; leg pain (side effect); morbidity; nonhuman; off label drug use; ossification; osteolysis; postoperative complication (complication); postoperative pain (complication); postoperative period; priority journal; publication; radiculitis (complication); reoperation; respiratory tract disease (side effect); respiratory tract intubation; retrograde ejaculation (side effect); review; risk; speech disorder (side effect); spinal cord injury; surgeon; swelling (side effect); systematic review; tracheotomy; treatment outcome; urogenital tract disease (side effect); wound complication (side effect); 
DRUG MANUFACTURERS
   (United States)Medtronic
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011366775
MEDLINE PMID
  21729796 (http://www.ncbi.nlm.nih.gov/pubmed/21729796)
PUI
  L362073041
DOI
  10.1016/j.spinee.2011.04.023
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.spinee.2011.04.023
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15299430&id=doi:10.1016%2Fj.spinee.2011.04.023&atitle=A+critical+review+of+recombinant+human+bone+morphogenetic+protein-2+trials+in+spinal+surgery%3A+Emerging+safety+concerns+and+lessons+learned&stitle=Spine+J.&title=Spine+Journal&volume=11&issue=6&spage=471&epage=491&aulast=Carragee&aufirst=Eugene+J.&auinit=E.J.&aufull=Carragee+E.J.&coden=SJPOA&isbn=&pages=471-491&date=2011&auinit1=E&auinitm=J
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 673
TITLE
  Vinorelbine in progressive unresectable low-grade glioma in children
AUTHOR NAMES
  Cappellano A.M.; Bouffet E.; Silva F.; Paiva P.; Alves M.T.D.S.; Cavalheiro S.; Silva N.S.
AUTHOR ADDRESSES
  (Cappellano A.M.; Bouffet E.; Silva F.; Paiva P.; Alves M.T.D.S.; Cavalheiro 
S.; Silva N.S.) IOP/GRAACC/UNIFESP, Sao Paulo, Brazil.
(Cappellano A.M.; Bouffet E.; Silva F.; Paiva P.; Alves M.T.D.S.; Cavalheiro 
S.; Silva N.S.) Hospital for Sick Children, Toronto, Canada.
(Cappellano A.M.; Bouffet E.; Silva F.; Paiva P.; Alves M.T.D.S.; Cavalheiro 
S.; Silva N.S.) IOP/GRAA/UNIFESP, Sao Paulo, Brazil.
(Cappellano A.M.; Bouffet E.; Silva F.; Paiva P.; Alves M.T.D.S.; Cavalheiro 
S.; Silva N.S.) Department of Pathology, Sao Paulo, Brazil.
CORRESPONDENCE ADDRESS
  A.M. Cappellano, IOP/GRAACC/UNIFESP, Sao Paulo, Brazil.
FULL RECORD ENTRY DATE
  2012-04-10
SOURCE
  Journal of Clinical Oncology (2011) 29:15 SUPPL. 1. Date of Publication: 20 
May 2011
VOLUME
  29
ISSUE
  15
DATE OF PUBLICATION
  20 May 2011
CONFERENCE NAME
  ASCO Annual Meeting 2011
CONFERENCE LOCATION
  Chicago, IL, United States
CONFERENCE DATE
  2011-06-03 to 2011-06-07
ISSN
  0732-183X
BOOK PUBLISHER
  American Society of Clinical Oncology
ABSTRACT
  Background: Low grade glioma represent 30-40% off all childhood brain 
tumors. Optimal treatment when feasible is surgical resection resulting in 
cure in the majority of the cases. However, the management of progressive 
unresectable low-grade glioma (PULGG) remains controversial. There is 
increasing evidence that chemotherapy can delay or even allow avoidance of 
radiotherapy and/or surgery in these unresectable tumors. Several protocols 
have been described. However, short and long term toxicity remains a major 
issue in this chronic disease. Within this context, we present our 
experience with single agent vinorelbine, a semi-synthetic vinca alkaloid. 
Methods:From July 2007 to January 2011, 32 patients with recurrent (10) or 
newly diagnosed (22) PULGG started treatment with vinorelbine 30 mg/m(2) on 
days 0, 8 and 22 for a total of 18 cycles. Tumor site was 
hypothalamic/chiasmatic (19), spinal cord (1), cortex (1), cerebellum (1), 
brainstem (4), multifocal (3) and 2 patients had gliomatosis. Four children 
had neurofibromatosis and 3 diencephalic syndrome. Twenty- two patients had 
prior neurosurgical intervention. Response criteria were based on magnetic 
resonance imaging and physical examination. Results: Twenty- eight patients 
(median age 7 years 1 month) were evaluable after 4 cycles of vinorelbine, 
with objective response (OR) in 9 patients, stable disease (SD) in 19. After 
8 cycles, 25 patients were evaluable with 9 OR, 15 SD and 1 PD. After 18 
cycles, 18 patients were evaluable for response, 5 with OR, 10 SD and 3 PD. 
Three patients died: one of disease progression, one of atypical pneumonia 
and one of tracheotomy obstruction. Toxicity was mild and manageable in most 
cases: Grade I/II gastrointestinal toxicity was observed in 9 patients, 
grade I/II neurotoxicity in 2 patients and grade IV hematologic toxicity in 
3 patients. Conclusions: Our preliminary results suggest that vinorelbine is 
active in patients with ULGG. This drug offers several advantages including 
a low toxicity profile associated with excellent quality of life.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  vinorelbine tartrate; 
EMTREE DRUG INDEX TERMS
  Vinca alkaloid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child; glioma; human; 
EMTREE MEDICAL INDEX TERMS
  brain stem; brain tumor; cerebellum cortex; chemotherapy; childhood; chronic disease; disease course; gastrointestinal toxicity; gliosis; neoplasm; neurofibromatosis; neurotoxicity; nuclear magnetic resonance imaging; obstruction; patient; physical examination; quality of life; radiotherapy; spinal cord; surgery; toxicity; tracheotomy; virus pneumonia; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70712119
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0732183X&id=doi:&atitle=Vinorelbine+in+progressive+unresectable+low-grade+glioma+in+children&stitle=J.+Clin.+Oncol.&title=Journal+of+Clinical+Oncology&volume=29&issue=15&spage=&epage=&aulast=Cappellano&aufirst=A.M.&auinit=A.M.&aufull=Cappellano+A.M.&coden=&isbn=&pages=-&date=2011&auinit1=A&auinitm=M
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 674
TITLE
  Long-term ventilation in children: Epidemiology of an epidemic
AUTHOR NAMES
  McDougall C.M.; Adderley R.; Wensley D.F.; Seear M.D.
AUTHOR ADDRESSES
  (McDougall C.M., cmcdougall@cw.bc.ca; Wensley D.F.; Seear M.D.) BC 
Children's Hospital, Vancouver, Canada.
(Adderley R.) British Columbia Children's Hospital, Vancouver, Canada.
CORRESPONDENCE ADDRESS
  C.M. McDougall, BC Children's Hospital, Vancouver, Canada. Email: 
cmcdougall@cw.bc.ca
FULL RECORD ENTRY DATE
  2012-09-03
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2011) 183:1 
MeetingAbstracts. Date of Publication: 1 May 2011
VOLUME
  183
ISSUE
  1
DATE OF PUBLICATION
  1 May 2011
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2011
CONFERENCE LOCATION
  Denver, CO, United States
CONFERENCE DATE
  2011-05-13 to 2011-05-18
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction Children with special healthcare needs, including those 
benefiting from advanced technologies, represent an increasing segment of 
the population. Cross-sectional studies have suggested that paediatric 
long-term ventilation (LTV) has expanded rapidly over the last 20 years. We 
sought to describe longitudinal trends in LTV in a single regional referral 
centre which provides all paediatric LTV care for the province of British 
Columbia (population 4 million). Methods Retrospective data was collected on 
all patients receiving LTV (medically stable patients ventilated for ≥ 3 
months(1)) at BC Children's Hospital between 1.1.95 and 31.12.09. Data was 
subdivided into 5-year epochs for statistical analysis (χ(2) test). Results 
145 children (85 male) commenced LTV during the 15-year period. 28 (19%) 
were ventilated invasively via tracheostomy (all bilevel) and 117 (81%) 
received non-invasive ventilation (NIV) (22 CPAP, 95 bilevel). 17 (12%) were 
ventilated 24 hours/day while 128 (88%) were supported < 24 hours/day. 
Median age at initiation of LTV was 9.4 (0-23) years but there was a bimodal 
distribution with peaks in the 1(st) and 14th years of life. Principal 
diagnostic categories were: neuromuscular disease (46%), spinal injury (6%), 
abnormal ventilatory control (13%), craniofacial abnormality/OSA (17%), 
tracheomalacia (8%) and “other” (10%). 8 (5%) patients died, 27 (19%) 
discontinued respiratory support after a median of 1.8 (0.2-11.5) years and 
38 (26%) transitioned to adult care. Trends in incidence and prevalence of 
LTV are shown in Figure 1. Using census data(2), the calculated incidence 
rate has increased from 1/10(6) children/year in 1996 to 14/10(6) 
children/year in 2006, with a corresponding increase in prevalence from 6 to 
74/10(6) children. (Figure presented) Incidence of LTV increased 
significantly across the 3 5-year epochs (Table 1), due to a significant 
increase in NIV. The number of LTV patients with neuromuscular disease, 
abnormal ventilatory control and craniofacial problems/OSA increased over 
time. The number of patients transitioned to adult services has increased 
significantly. (Table presented) Conclusions The incidence of LTV in 
children has increased significantly over the last 15 years, with an 
accompanying 10-fold increase in prevalence. Although some children are able 
to discontinue respiratory support, a growing number are being transferred 
to adult care. LTV patients are resource-intensive. Future planning of 
paediatric hospital and community services, as well as adult services, must 
take into account the needs of this growing population.
EMTREE DRUG INDEX TERMS
  recombinant erythropoietin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  air conditioning; child; epidemic; epidemiology; human; society; 
EMTREE MEDICAL INDEX TERMS
  adult; assisted ventilation; Canada; cross-sectional study; diagnosis; health care need; hospital; incidence; male; neuromuscular disease; patient; pediatric hospital; planning; population; population research; prevalence; social welfare; spine injury; statistical analysis; technology; tracheomalacia; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70850964
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Long-term+ventilation+in+children%3A+Epidemiology+of+an+epidemic&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=183&issue=1&spage=&epage=&aulast=McDougall&aufirst=C.M.&auinit=C.M.&aufull=McDougall+C.M.&coden=&isbn=&pages=-&date=2011&auinit1=C&auinitm=M
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 675
TITLE
  Spinal Muscular Atrophy with Respiratory Distress (SMARD1) - A rare form of 
Spinal Muscular Atrophy
AUTHOR NAMES
  Ganesan S.; Hussain N.; Gosalakkal J.
AUTHOR ADDRESSES
  (Ganesan S.) Nottingham University Hospitals, NHS Trust, United Kingdom.
(Hussain N.; Gosalakkal J.) Leicester Royal Infirmary NHS Trust, United 
Kingdom.
CORRESPONDENCE ADDRESS
  S. Ganesan, Nottingham University Hospitals, NHS Trust, United Kingdom.
FULL RECORD ENTRY DATE
  2011-06-21
SOURCE
  European Journal of Paediatric Neurology (2011) 15 SUPPL. 1 (S95). Date of 
Publication: May 2011
VOLUME
  15
FIRST PAGE
  S95
DATE OF PUBLICATION
  May 2011
CONFERENCE NAME
  9th Congress of the European Paediatric Neurology Society, EPNS 2011
CONFERENCE LOCATION
  Cavtat, Croatia
CONFERENCE DATE
  2011-05-11 to 2011-05-14
ISSN
  1090-3798
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a form 
of spinal muscular atrophy characterized by IUGR, often premature birth, 
foot deformity, and a characteristic pattern of breathing that indicates 
weakness of the diaphragm. Most patients present at the age of 1 to 6 months 
with respiratory failure and progressive muscle weakness with predominantly 
distal lower limb muscle involvement. They may be ventilator dependent and 
difficult to wean from the ventilator. Early involvement of the diaphragm 
and predominance of distal muscle weakness clearly distinguishes SMARD1 from 
Type 1 SMA. SMARD1 is not linked to the SMN1 gene locus on chromosome 5q13 
(classic SMA), but is caused by mutations in the IGHMBP2 gene on chromosome 
11q13. We present 7 months old infant admitted to PICU at the age of 5 weeks 
with Bronchiolitis and respiratory failure. She was term IUGR baby initially 
admitted to SCBU for 2 weeks needing NCPAP and had feeding difficulties. She 
remained ventilated for 4 weeks with 3 failed extubations and repeated 
respiratory infections. Her initial investigations for respiratory failure 
and repeated failed extubations included flexible bronchoscopy, CT scan 
chest, CF work up, Echo, MRI brain scan which was unremarkable. She had 
Neurometabolic investigations which were unremarkable. EMG/NCS suggested 
severe motor axonal neuropathy. Bloods for SMA gene testing was negative. 
Skin and muscle biopsy were unremarkable. Genetic testing for SMARD 
(mutations in the IGHMBP2) came back as positive but it was heterozygous on 
2 genetic loci on the chromosome. So we tested the parents who were the 
carriers of the same mutations. It is not been described in the literature 
before. The child was successfully extubated with tracheostomy in place and 
currently on non invasive ventilation having multidisciplinary care. Always 
look for neuromuscular conditions if the child is ventilator dependent. 
SMARD1 is a rare form of spinal muscular atrophy and diagnosis helped in 
future management of the child and her family.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neurology; respiratory distress; society; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; baby; blood; brain scintiscanning; breathing; bronchiolitis; bronchoscopy; child; chromosome; chromosome 11; chromosome 5; computer assisted tomography; diagnosis; diaphragm; extubation; feeding disorder; foot malformation; gene; gene locus; genetic screening; infant; leg muscle; muscle biopsy; muscle weakness; mutation; neuropathy; nuclear magnetic resonance imaging; parent; patient; prematurity; respiratory failure; respiratory tract infection; skin; thorax; tracheostomy; ventilator; weakness; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70441041
DOI
  10.1016/S1090-3798(11)70329-4
FULL TEXT LINK
  http://dx.doi.org/10.1016/S1090-3798(11)70329-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10903798&id=doi:10.1016%2FS1090-3798%2811%2970329-4&atitle=Spinal+Muscular+Atrophy+with+Respiratory+Distress+%28SMARD1%29+-+A+rare+form+of+Spinal+Muscular+Atrophy&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=15&issue=&spage=S95&epage=&aulast=Ganesan&aufirst=S.&auinit=S.&aufull=Ganesan+S.&coden=&isbn=&pages=S95-&date=2011&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 676
TITLE
  Postoperative obstructing laryngeal edema in patients with diffuse 
idiopathic skeletal hyperostosis of cervical spine-A report of two cases-
AUTHOR NAMES
  Kim Y.-S.; Lee J.J.; Chung Y.H.; Kim E.S.; Chung I.-S.
AUTHOR ADDRESSES
  (Kim Y.-S.; Lee J.J., ljj6625@gmail.com; Chung Y.H.; Chung I.-S.) 
Departments of Anesthesiology and Pain Medicine, Sungkyunkwan University 
School of Medicine, 50, Ilwon-dong, Kangnam-gu, Seoul 135-710, South Korea.
(Kim E.S.) Departments of Neurosurgery, Samsung Medical Center, Sungkyunkwan 
University School of Medicine, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  J. J. Lee, Departments of Anesthesiology and Pain Medicine, Sungkyunkwan 
University School of Medicine, 50, Ilwon-dong, Kangnam-gu, Seoul 135-710, 
South Korea. Email: ljj6625@gmail.com
AiP/IP ENTRY DATE
  2011-06-20
FULL RECORD ENTRY DATE
  2011-06-23
SOURCE
  Korean Journal of Anesthesiology (2011) 60:5 (377-380). Date of Publication: 
May 2011
VOLUME
  60
ISSUE
  5
FIRST PAGE
  377
LAST PAGE
  380
DATE OF PUBLICATION
  May 2011
ISSN
  2005-6419
  2005-7563 (electronic)
BOOK PUBLISHER
  Korean Society of Anesthesiologists, 314-1,2-Ga Hangangro, Yongsan-gu, 
Seoul, South Korea.
ABSTRACT
  Two cases were reported in which severe postoperative laryngeal edema were 
developed after the operation of diffuse idiopathic skeletal hyperostosis 
(DISH) of cervical spine. In the first case, sudden airway obstruction was 
developed in the general ward 6 hour after uneventful decompression surgery 
for osteophyte. In the second patient, an elective preoperative tracheostomy 
was performed before surgery but the tube could not be removed for 2 months 
because of laryngeal edema and decreased vocal cord mobility. It should be 
emphasized that this airway problem can develop during the postoperative as 
well as the preoperative period, especially in the case of anterior cervical 
spine surgery. © the Korean Society of Anesthesiologists, 2011.
EMTREE DRUG INDEX TERMS
  heparin; rocuronium; sevoflurane; thiopental; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; diffuse idiopathic skeletal hyperostosis (surgery); larynx edema (complication); postoperative complication (complication); spine disease (surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; anticoagulant therapy; article; case report; computer assisted tomography; decompression surgery; drug withdrawal; dysphagia; elective surgery; human; male; osteophyte; percutaneous coronary intervention; physical examination; postoperative period; preoperative period; spine radiography; tracheostomy; vocal cord; 
CAS REGISTRY NUMBERS
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
  rocuronium (119302-91-9)
  sevoflurane (28523-86-6)
  thiopental (71-73-8, 76-75-5)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011322328
PUI
  L361932528
DOI
  10.4097/kjae.2011.60.5.377
FULL TEXT LINK
  http://dx.doi.org/10.4097/kjae.2011.60.5.377
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20056419&id=doi:10.4097%2Fkjae.2011.60.5.377&atitle=Postoperative+obstructing+laryngeal+edema+in+patients+with+diffuse+idiopathic+skeletal+hyperostosis+of+cervical+spine-A+report+of+two+cases-&stitle=Korean+J.+Anesth.&title=Korean+Journal+of+Anesthesiology&volume=60&issue=5&spage=377&epage=380&aulast=Kim&aufirst=Young-Soon&auinit=Y.-S.&aufull=Kim+Y.-S.&coden=&isbn=&pages=377-380&date=2011&auinit1=Y&auinitm=-S
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 677
TITLE
  Hereditary adult-onset alexander disease
AUTHOR NAMES
  Beliveau N.
AUTHOR ADDRESSES
  (Beliveau N.) University of Minnesota, Minneapolis, United States.
CORRESPONDENCE ADDRESS
  N. Beliveau, University of Minnesota, Minneapolis, United States.
FULL RECORD ENTRY DATE
  2011-05-30
SOURCE
  Journal of Hospital Medicine (2011) 6:4 SUPPL. 2 (S155-S156). Date of 
Publication: April 2011
VOLUME
  6
ISSUE
  4
FIRST PAGE
  S155
LAST PAGE
  S156
DATE OF PUBLICATION
  April 2011
CONFERENCE NAME
  Hospital Medicine 2011, HM 2011
CONFERENCE LOCATION
  Grapevine, TX, United States
CONFERENCE DATE
  2011-05-10 to 2011-05-13
ISSN
  1553-5592
BOOK PUBLISHER
  John Wiley and Sons Inc.
ABSTRACT
  Case Presentation: A 47-year-old white man with a history of alcohol abuse 
was transferred to our hospital with loss of consciousness and subsequently 
intubated en route for airway protection. His medical history was 
unremarkable. On initial presentation, the patient was sedated and 
comfortable on mechanical ventilation. Vital signs were normal. Physical 
exam, off sedation, was notable for bilateral conjugate gaze, intact corneal 
reflexes, minimal movements in extremities but not against gravity, deep 
tendon reflexes 2+ in both upper and lower extremities, and bilateral 
positive Babinski's sign. Workup including a complete blood count, complete 
metabolic panel, drug screen, chest x-ray, pan-culture, echocardiography, 
and CT head/cervical spine were nonrevealing, except for elevated alcohol 
level on admission. MRI of the brain stem revealed severe generalized 
cerebral atrophy extending caudally to the proximal cervical spinal cord on 
T2 and T2 FLAIR images. Cerebrospinal fluid analysis included protein 
electrophoresis, acidfast bacilli smear, and culture, Herpes, West Nile 
virus, toxoplasmosis, syphilis, and Lyme titers were unremarkable. 
Electroencephalography showed no epileptiform activity. On further 
investigation, family history was notable for the presence of Alexander 
disease (AD). A pedigree of his family showed 10 of 20 family members were 
affected. The diagnosis of AD had been confirmed on autopsy in family 
members, and typical MRI findings were described in the affected family 
members. Based on the MRI and an inheritance pattern in the family, the 
diagnosis of adult-onset Alexander disease was made, and likely progression 
of thedisease was attributed to his chronic excessive alcohol intake. The 
patient remained ventilator dependent and subsequently underwent 
tracheostomy. Discussion: Adult-onset Alexander disease (AOAD) is a subtype 
of Alexander disease, a rare and often fatal leukodystrophy, characterized 
pathologically by the accumulation of eosinophilic inclusions in astrocyte 
cytoplasm (Rosenthal fibers), resulting from nonconservative mutations of 
chromosome 17q21, which encodes GFAP. It has an autosomal dominant mode of 
inheritance. Near 450 cases have been reported worldwide since Alexander's 
initial description in 1949. AOAD has variable features, including bulbar 
and pseudobulbar signs, spasticity, quadriparesis, and dysautonomia. Atrophy 
of the medulla and upper cervical spinal cord on MRI is a characteristic 
finding. Because of the rarity of the disease and the lack of controlled 
clinical trials, there are no clear recommendations about the diagnosis and 
treatment of AOAD. Its diagnosis does not require genetic testing and can be 
established based on clinical and MRI features. Conclusions: The purpose of 
reporting this case is to increase the general awareness of this rare 
condition and to provide an up-to-date literature review.
EMTREE DRUG INDEX TERMS
  alcohol; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult; Alexander disease; hospital; 
EMTREE MEDICAL INDEX TERMS
  airway; alcohol abuse; alcohol consumption; artificial ventilation; astrocyte; atrophy; autopsy; autosomal dominant inheritance; Babinski reflex; Bacilli; blood cell count; brain atrophy; brain stem; cerebrospinal fluid analysis; cervical spinal cord; chromosome 17; conjugate; consciousness; controlled clinical trial (topic); cornea reflex; cytoplasm; diagnosis; dysautonomia; echocardiography; electroencephalography; family history; fiber; gaze; genetic screening; gravity; herpes simplex; inheritance; leg; leukodystrophy; male; medical history; mutation; nuclear magnetic resonance imaging; patient; pedigree; protection; protein electrophoresis; quadriplegia; sedation; smear; spasticity; spine; syphilis; tendon reflex; thorax radiography; toxoplasmosis; tracheostomy; ventilator; vital sign; West Nile virus; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70423427
DOI
  10.1002/jhm.920
FULL TEXT LINK
  http://dx.doi.org/10.1002/jhm.920
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15535592&id=doi:10.1002%2Fjhm.920&atitle=Hereditary+adult-onset+alexander+disease&stitle=J.+Hosp.+Med.&title=Journal+of+Hospital+Medicine&volume=6&issue=4&spage=S155&epage=S156&aulast=Beliveau&aufirst=Nadiya&auinit=N.&aufull=Beliveau+N.&coden=&isbn=&pages=S155-S156&date=2011&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 678
TITLE
  The Isadora syndrome: A case report of cervical, oesophageal and tracheal 
transection in a go-karting accident
AUTHOR NAMES
  Ahmad M.; Sinha P.; Al-Tamimi Y.Z.; Sylvester D.; Dezso A.; Timothy J.
AUTHOR ADDRESSES
  (Ahmad M., maleehahmad@mac.com; Sinha P.; Al-Tamimi Y.Z.; Timothy J.) 
Department of Neurosurgery, Leeds General Infirmary, Leeds, United Kingdom.
(Sylvester D.; Dezso A.) Department of Ear, Nose and Throat (ENT) Surgery, 
Leeds General Infirmary, Leeds, United Kingdom.
CORRESPONDENCE ADDRESS
  M. Ahmad, Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom. Email: 
maleehahmad@mac.com
AiP/IP ENTRY DATE
  2011-03-09
FULL RECORD ENTRY DATE
  2011-03-15
SOURCE
  British Journal of Neurosurgery (2011) 25:2 (310-312). Date of Publication: 
April 2011
VOLUME
  25
ISSUE
  2
FIRST PAGE
  310
LAST PAGE
  312
DATE OF PUBLICATION
  April 2011
ISSN
  0268-8697
  1360-046X (electronic)
BOOK PUBLISHER
  Informa Healthcare, 69-77 Paul Street, London, United Kingdom.
ABSTRACT
  We report a case of cervical spine, tracheal and oesophageal trauma from a 
go-karting injury caused by the patient's scarf catching in the vehicle's 
wheel. We discuss the significance of the pre-hospital and operative 
management of this potentially life-threatening injury by a multi-specialty 
surgical team. The importance of health and safety issues in recreational 
sports is highlighted in view of the increasing incidence of cervical spine 
trauma over past two decades. © 2011 The Neurosurgical Foundation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (diagnosis, etiology); esophagus injury (diagnosis, etiology); isadora syndrome (diagnosis, etiology); trachea injury (diagnosis, etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; emergency ward; endotracheal tube; female; Glasgow coma scale; human; postoperative period; priority journal; recreation; surgical approach; surgical technique; tracheostomy; tracheotomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011120893
MEDLINE PMID
  21545330 (http://www.ncbi.nlm.nih.gov/pubmed/21545330)
PUI
  L361350588
DOI
  10.3109/02688697.2010.544788
FULL TEXT LINK
  http://dx.doi.org/10.3109/02688697.2010.544788
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02688697&id=doi:10.3109%2F02688697.2010.544788&atitle=The+Isadora+syndrome%3A+A+case+report+of+cervical%2C+oesophageal+and+tracheal+transection+in+a+go-karting+accident&stitle=Br.+J.+Neurosurg.&title=British+Journal+of+Neurosurgery&volume=25&issue=2&spage=310&epage=312&aulast=Ahmad&aufirst=Maleeha&auinit=M.&aufull=Ahmad+M.&coden=BJNEE&isbn=&pages=310-312&date=2011&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 679
TITLE
  Decannulation: In the ICU or in the ward? Does it really matter?
AUTHOR NAMES
  Milercy O.; López J.; Figueira J.; Manzanares J.; Hernández M.
AUTHOR ADDRESSES
  (Milercy O.; López J.; Figueira J.; Manzanares J.; Hernández M.) La Paz 
Hospital, Madrid, Spain.
CORRESPONDENCE ADDRESS
  O. Milercy, La Paz Hospital, Madrid, Spain.
FULL RECORD ENTRY DATE
  2011-11-29
SOURCE
  Critical Care (2011) 15 SUPPL. 1 (S60). Date of Publication: 11 Apr 2011
VOLUME
  15
FIRST PAGE
  S60
DATE OF PUBLICATION
  11 Apr 2011
CONFERENCE NAME
  31st International Symposium on Intensive Care and Emergency Medicine
CONFERENCE LOCATION
  Brussels, Belgium
CONFERENCE DATE
  2011-03-22 to 2011-03-25
ISSN
  1364-8535
BOOK PUBLISHER
  BioMed Central Ltd.
ABSTRACT
  Introduction: The aim of our study was to evaluate the in-hospital mortality 
of patients who underwent tracheostomy during their ICU admission, and were 
discharged to different areas of the hospital prior to decannulation. 
Methods: A prospective observational study of a group of patients who 
underwent tracheostomy in our ICU from January 2001 to December 2007 and 
were discharged to different areas of the hospital prior to decannulation. 
The mortality of patients decannulated or not in the wards was reviewed. 
Results: Between January 2001 and December 2007, 6,333 patients were 
admitted to our unit. A total of 1,528 needed mechanical ventilation (MV) 
for more than 48 hours. Four hundred and fortythree underwent tracheostomy 
(29% of patients needed prolonged MV). Mean age was 56 years, 66% were male. 
Mean APACHE II score was 20. The main diagnoses were polytrauma that 
included head injury (24.2%), other structural neurological diseases (21%), 
prolonged weaning of several etiologies - sepsis, post-surgical (35%). 
Tracheostomy was performed with the percutaneous dilatational technique 
(PDT) in most cases (90%). The most frequent complication was subglottic 
stenosis presenting in 15 patients. Ninety-two patients (20.77%) died in the 
ICU and 351 were discharged to different wards. Of these 351, 161 (45.8%) 
could be decannulated in the ICU and 109 (31%) in the wards. Eighty-one 
patients (23%) could not be decannulated. The ward mortality in patients 
decannulated in the ICU was 5.6% (9/161), for those decannulated in the 
wards was 10% (11/109). In patients not decannulated the mortality reached 
37% (30/81). There were no differences of statistical significance in 
mortality between patients decannulated in the ICU and patients decannulated 
in the wards (5.6% vs. 10%; OR = 1.9 CI = 0.8 to 4.2). The main diagnoses in 
the patients who died on the wards were: 31 residual encephalopathy 
(post-anoxic, post-traumatic, others), fi ve severe chronic respiratory 
failure, three spinal cord injury, two neuromuscular disease. Conclusions: 
Mortality was not related to whether decannulation was done in the ICU or on 
the ward. Although mortality was higher in the group of patients that could 
not be decannulated in either setting due to their poor neurological or 
functional status. Several authors suggest tracheostomy in these patients 
only delays their death without improving overall in-hospital survival due 
to their poor vital prognosis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency medicine; intensive care; ward; 
EMTREE MEDICAL INDEX TERMS
  APACHE; artificial ventilation; brain disease; chronic respiratory failure; death; diagnosis; etiology; functional status; head injury; hospital; human; male; mortality; multiple trauma; neurologic disease; neuromuscular disease; observational study; patient; prognosis; sepsis; spinal cord injury; statistical significance; subglottic stenosis; survival; tracheostomy; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70587405
DOI
  10.1186/cc9588
FULL TEXT LINK
  http://dx.doi.org/10.1186/cc9588
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13648535&id=doi:10.1186%2Fcc9588&atitle=Decannulation%3A+In+the+ICU+or+in+the+ward%3F+Does+it+really+matter%3F&stitle=Crit.+Care&title=Critical+Care&volume=15&issue=&spage=S60&epage=&aulast=Milercy&aufirst=O.&auinit=O.&aufull=Milercy+O.&coden=&isbn=&pages=S60-&date=2011&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 680
TITLE
  Swallowing dysfunction after mechanical ventilation in trauma patients
AUTHOR NAMES
  Brown C.V.R.; Hejl K.; Mandaville A.D.; Chaney P.E.; Stevenson G.; Smith C.
AUTHOR ADDRESSES
  (Brown C.V.R., cvrbrown@seton.org; Hejl K.; Mandaville A.D.; Chaney P.E.; 
Stevenson G.; Smith C.) University Medical Center Brackenridge, Austin, TX, 
United States.
CORRESPONDENCE ADDRESS
  C.V.R. Brown, University Medical Center at Brackenridge, Trauma Services, 
Austin, TX 78701, United States. Email: cvrbrown@seton.org
AiP/IP ENTRY DATE
  2010-09-28
FULL RECORD ENTRY DATE
  2011-02-15
SOURCE
  Journal of Critical Care (2011) 26:1 (108.e9-108.e13). Date of Publication: 
February 2011
VOLUME
  26
ISSUE
  1
DATE OF PUBLICATION
  February 2011
ISSN
  0883-9441
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Background: Swallowing dysfunction can occur after mechanical ventilation, 
leading to complications such as aspiration and pneumonia. After mechanical 
ventilation, authors have recommended evaluating patients with contrast 
studies or endoscopy to identify patients at risk for swallowing dysfunction 
and aspiration. The purpose of the study was to determine if a bedside 
swallowing evaluation (BSE) can identify patients with swallowing 
dysfunction after mechanical ventilation. Methods: This is a 1-year (2008) 
prospective study of all adult trauma patients admitted to the intensive 
care unit requiring mechanical ventilation. Upon separation from mechanical, 
all patients received a BSE. The BSE used mental status, facial symmetry, 
swallow reflex, and oral ice chips and water to identify swallowing 
dysfunction. Patients who passed the BSE were advanced to oral intake per 
physician orders, whereas patients who failed the BSE were allowed nothing 
by mouth. Results: A total of 345 patients were included; 54 died before 
separation from mechanical ventilation and were excluded. The remaining 291 
patients underwent BSE after separation from mechanical ventilation, with 
143 (49%) passing and 148 (51%) failing. Patients who failed the BSE 
required mechanical ventilation longer than those who passed (14 ± 13 vs 5 ± 
20 days, P = 001). In addition, only 23% of patients extubated within 72 
hours failed the BSE, whereas 78% of those intubated more than 72 hours 
failed the BSE (P < .001). All patients who passed the BSE were discharged 
from the hospital without a clinical aspiration event. Independent risk 
factors for failure of BSE included tracheostomy, older age, prolonged 
mechanical ventilation, delirium tremens, traumatic brain injury, and spine 
fracture. Three (2%) patients who failed the BSE had a clinical aspiration 
event despite taking nothing by mouth. Conclusions: A simple BSE can be used 
to identify patients at risk for swallowing dysfunction after mechanical 
ventilation. More importantly, BSE can safely clear patients without 
swallowing dysfunction, avoiding costly and time-consuming contrast studies 
or endoscopic evaluation. © 2011 Elsevier Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; dysphagia (complication); extubation; 
EMTREE MEDICAL INDEX TERMS
  adult; age distribution; aged; article; bedside swallowing evaluation; clinical evaluation; controlled study; delirium tremens; female; fluid intake; human; intensive care unit; major clinical study; male; mental health; prospective study; risk factor; spine fracture; swallowing; tracheostomy; traumatic brain injury; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011072312
MEDLINE PMID
  20869841 (http://www.ncbi.nlm.nih.gov/pubmed/20869841)
PUI
  L51083561
DOI
  10.1016/j.jcrc.2010.05.036
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jcrc.2010.05.036
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08839441&id=doi:10.1016%2Fj.jcrc.2010.05.036&atitle=Swallowing+dysfunction+after+mechanical+ventilation+in+trauma+patients&stitle=J.+Crit.+Care&title=Journal+of+Critical+Care&volume=26&issue=1&spage=&epage=&aulast=Brown&aufirst=Carlos+V.R.&auinit=C.V.R.&aufull=Brown+C.V.R.&coden=JCCAE&isbn=&pages=-&date=2011&auinit1=C&auinitm=V.R.
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 681
TITLE
  One thousand bedside percutaneous tracheostomies in the surgical intensive 
care unit: Time to change the gold standard
AUTHOR NAMES
  Kornblith L.Z.; Burlew C.C.; Moore E.E.; Haenel J.B.; Kashuk J.L.; Biffl W.L.; Barnett C.C.; Johnson J.L.
AUTHOR ADDRESSES
  (Kornblith L.Z.; Burlew C.C., clay.cothren@dhha.org; Moore E.E.; Haenel 
J.B.; Kashuk J.L.; Biffl W.L.; Barnett C.C.; Johnson J.L.) Department of 
Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, 
United States.
CORRESPONDENCE ADDRESS
  C. C. Burlew, Department of Surgery, Denver Health Medical Center, MC 0206, 
777 Bannock St, Denver, CO 80204, United States. Email: 
clay.cothren@dhha.org
AiP/IP ENTRY DATE
  2011-01-04
FULL RECORD ENTRY DATE
  2011-02-15
SOURCE
  Journal of the American College of Surgeons (2011) 212:2 (163-170). Date of 
Publication: February 2011
VOLUME
  212
ISSUE
  2
FIRST PAGE
  163
LAST PAGE
  170
DATE OF PUBLICATION
  February 2011
ISSN
  1072-7515
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Background: Bedside percutaneous tracheostomy (BPT) is a cost-effective 
alternative to open tracheostomy. Small series have consistently documented 
minimal morbidity, but BPT has yet to be embraced as the standard of care. 
Because this has been our preferred technique in the surgical ICU for more 
than 20 years, we reviewed our experience to ascertain its safety. We 
hypothesize that BPT has acceptably minimal morbidity, even in high-risk 
patients. Study Design Patients undergoing BPT from January 1998 to June 
2008 were reviewed. High-risk patients were defined as those with cervical 
collar or halo, cervical spine injuries, systemic heparinization, positive 
end-expiratory pressure >10 cm H(2)O or fraction of inspired oxygen > 50%. 
Results During the study period, 1,000 patients underwent BPT (74% men; mean 
± SEM age 46 ± 0.6 years; 70% trauma). BPT was performed 8.9 ± 0.2 days 
(mean ± SEM) after admission. Patients remained ventilator dependent for an 
additional 9.7 ± 0.4 days (mean ± SEM). There were 482 (48%) patients 
undergoing BPT who were considered high-risk: 1 risk category, 273 patients; 
2 risk categories, 139 patients; 3 risk categories, 56 patients; 4 risk 
categories, 12 patients; 5 risk categories, 2 patients. Complications 
occurred in 14 (1.4%) patients. Early complications included tracheostomy 
tube misplacement requiring revision (n = 4), bleeding requiring 
intervention (n = 2), infection (n = 1), and procedure failure requiring 
cricothyroidotomy (n = 1). Late complications included persistent stoma 
requiring operative closure (n = 4) and subglottic stenosis (n = 2). There 
were 6 complications (1.2%) in normal risk and 8 complications (1.7%) in 
high-risk patients. There were no deaths related to BPT. Conclusions BPT in 
the surgical intensive care unit is a safe procedure, even in high-risk 
patients. We believe BPT is the new gold standard for patients requiring 
tracheostomy for mechanical ventilation. © 2011 American College of 
Surgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bedside percutaneous tracheostomy; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; bleeding (complication); cervical spine injury; female; heparinization; high risk patient; human; infection (complication); intensive care unit; major clinical study; male; morbidity; positive end expiratory pressure; priority journal; subglottic stenosis (complication); surgical mortality; 
EMBASE CLASSIFICATIONS
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011064694
MEDLINE PMID
  21193331 (http://www.ncbi.nlm.nih.gov/pubmed/21193331)
PUI
  L51208098
DOI
  10.1016/j.jamcollsurg.2010.09.024
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jamcollsurg.2010.09.024
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10727515&id=doi:10.1016%2Fj.jamcollsurg.2010.09.024&atitle=One+thousand+bedside+percutaneous+tracheostomies+in+the+surgical+intensive+care+unit%3A+Time+to+change+the+gold+standard&stitle=J.+Am.+Coll.+Surg.&title=Journal+of+the+American+College+of+Surgeons&volume=212&issue=2&spage=163&epage=170&aulast=Kornblith&aufirst=Lucy+Z.&auinit=L.Z.&aufull=Kornblith+L.Z.&coden=JACSE&isbn=&pages=163-170&date=2011&auinit1=L&auinitm=Z
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 682
TITLE
  Repeated vertebrobasilar thromboembolism in a patient with severe upper 
cervical instability because of rheumatoid arthritis
AUTHOR NAMES
  Oshima K.; Sakaura H.; Iwasaki M.; Nakura A.; Fujii R.; Yoshikawa H.
AUTHOR ADDRESSES
  (Oshima K., ko-osk@umin.ac.jp; Sakaura H.; Iwasaki M.; Nakura A.; Yoshikawa 
H.) Department of Orthopaedic Surgery, Osaka University, Graduate School of 
Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
(Oshima K., ko-osk@umin.ac.jp) Department of Musculoskeletal Oncology, 
National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
(Fujii R.) Department of Orthopaedic Surgery, Amagasaki Chuo Hospital, 
1-12-1 Shioe, Amagasaki, Hyogo 661-0976, Japan.
CORRESPONDENCE ADDRESS
  K. Oshima, Department of Musculoskeletal Oncology, National Cancer Center, 
5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Email: ko-osk@umin.ac.jp
AiP/IP ENTRY DATE
  2011-01-04
FULL RECORD ENTRY DATE
  2011-02-23
SOURCE
  Spine Journal (2011) 11:2 (e1-e5). Date of Publication: February 2011
VOLUME
  11
ISSUE
  2
DATE OF PUBLICATION
  February 2011
ISSN
  1529-9430
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Background context: Although many reports have examined upper cervical 
rheumatoid arthritis (RA) and spinal cord disorders resulting from RA 
lesions, few cases of thromboembolic events in the vertebrobasilar system 
associated with RA lesions of the upper cervical spine have been reported. 
Purpose: We encountered a rare case of repeated vertebrobasilar 
thromboembolism with severe upper cervical instability resulting from RA. 
Furthermore, we obtained clinical images of the vertebrobasilar system just 
before and after the first thromboembolic event. We thus present the case of 
a patient with RA who recovered without surgery from repeated 
vertebrobasilar thromboembolism that might have been caused by severe upper 
cervical instability. Study design: Case report. Methods: A 59-year-old man 
with a 14-year history of RA experienced nuchal pain because of severe 
atlantoaxial and vertical subluxations. While awaiting surgery, he developed 
left Wallenberg syndrome because of occlusion in the left vertebral artery 
(VA). Five days later, he displayed impaired consciousness and symptoms of 
right Wallenberg syndrome. Emergency magnetic resonance angiography showed 
occlusion in the basilar artery. After thrombolytic therapy, he gradually 
recovered. Results: Because we presumed that the patient's recurrent 
thrombus formation resulted from kinking of the right VA caused by severe 
instability of the upper cervical spine, we planned to treat him surgically 
despite his impaired consciousness and tracheostomy. However, the 
anesthesiologist would not approve surgery because the patient had high-risk 
conditions. The cervical spine was thus realigned and immobilized in a halo 
apparatus for 3 months to achieve stability. Now, more than 5 years after 
these events, the patient has experienced no more thromboembolic events and 
his condition has remained stable, without need for surgery. Conclusions: 
Repeated vertebrobasilar thromboembolism in patients with RA may sometimes 
be caused by severe upper cervical instability that can be treated without 
surgery. © 2011 Elsevier Inc.
EMTREE DRUG INDEX TERMS
  methotrexate (drug therapy); prednisolone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine instability; rheumatoid arthritis (drug therapy, drug therapy); spinal cord disease; thromboembolism (complication, therapy); vertebrobasilar thromboembolism (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; atlantoaxial subluxation; case report; cervical spine; cervical spine radiography; coil embolization; computer assisted tomography; disease severity; human; intractable pain; magnetic resonance angiography; male; neck pain; priority journal; tracheostomy; vertebral artery; vertebral artery stenosis; Wallenberg syndrome; 
CAS REGISTRY NUMBERS
  methotrexate (15475-56-6, 59-05-2, 7413-34-5)
  prednisolone (50-24-8)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011081812
MEDLINE PMID
  21193352 (http://www.ncbi.nlm.nih.gov/pubmed/21193352)
PUI
  L51210722
DOI
  10.1016/j.spinee.2010.11.015
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.spinee.2010.11.015
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15299430&id=doi:10.1016%2Fj.spinee.2010.11.015&atitle=Repeated+vertebrobasilar+thromboembolism+in+a+patient+with+severe+upper+cervical+instability+because+of+rheumatoid+arthritis&stitle=Spine+J.&title=Spine+Journal&volume=11&issue=2&spage=&epage=&aulast=Oshima&aufirst=Kazuya&auinit=K.&aufull=Oshima+K.&coden=SJPOA&isbn=&pages=-&date=2011&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 683
TITLE
  A classification and regression tree to assist clinical decision making in 
airway management for patients with cervical spinal cord injury
AUTHOR NAMES
  Berney S.C.; Gordon I.R.; Opdam H.I.; Denehy L.
AUTHOR ADDRESSES
  (Berney S.C., sue.berney@austin.org.au; Opdam H.I.) Austin Hospital 
Melbourne, C/O Physiotherapy HSB, 145 Studley Road, Melbourne, VIC 3084, 
Australia.
(Gordon I.R.) Statistical Consulting Service, University of Melbourne, 
Melbourne, VIC, Australia.
(Denehy L.) School of Health Sciences, University of Melbourne, Melbourne, 
VIC, Australia.
CORRESPONDENCE ADDRESS
  S. C. Berney, Austin Hospital, C/O Physiotherapy 3 HSB, 145 Studley Road, 
Melbourne, VIC 3084, Australia. Email: sue.berney@austin.org.au
AiP/IP ENTRY DATE
  2010-08-13
FULL RECORD ENTRY DATE
  2011-02-24
SOURCE
  Spinal Cord (2011) 49:2 (244-250). Date of Publication: February 2011
VOLUME
  49
ISSUE
  2
FIRST PAGE
  244
LAST PAGE
  250
DATE OF PUBLICATION
  February 2011
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design:This was a prospective observational study.Objectives:To review 
airway management of patients with acute cervical spinal cord injury (CSCI) 
who are admitted to the intensive care unit (ICU) and to develop a 
classification and regression tree (CART) to direct clinical decision making 
in airway management.Setting:This study was carried out in 
Australia.Methods:All patients with CSCI who required intubation and 
mechanical ventilation and who were admitted to ICU in three tertiary 
hospitals in Melbourne between October 2004 and May 2009 and two other 
interstate hospitals between December 2004 and December 2005 were included. 
Airway management was recorded.Results:A total of 114 patients were 
included. Tracheostomy insertion occurred in 68 patients (59.7%). Using CART 
analysis, it was found that the variables forced vital capacity, the volume 
of pulmonary secretion and gas exchange were predictive of airway management 
on 82.3% occasions with an 8.7% extubation failure rate.Conclusion:A CART 
can be useful in clinical decision making regarding airway management in 
CSCI. © 2011 International Spinal Cord Society All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; classification and regression tree; clinical classification; regression analysis; respiration control; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; Australia; clinical decision making; female; forced vital capacity; gas exchange; human; intensive care unit; intubation; lung pressure; major clinical study; male; multicenter study; priority journal; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011077805
MEDLINE PMID
  20697418 (http://www.ncbi.nlm.nih.gov/pubmed/20697418)
PUI
  L51028126
DOI
  10.1038/sc.2010.97
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2010.97
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2010.97&atitle=A+classification+and+regression+tree+to+assist+clinical+decision+making+in+airway+management+for+patients+with+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=49&issue=2&spage=244&epage=250&aulast=Berney&aufirst=S.C.&auinit=S.C.&aufull=Berney+S.C.&coden=SPCOF&isbn=&pages=244-250&date=2011&auinit1=S&auinitm=C
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 684
TITLE
  Effect of technique and timing of tracheostomy in patients with acute 
traumatic spinal cord injury undergoing mechanical ventilation
AUTHOR NAMES
  Ganuza J.R.; Forcada A.G.; Gambarrutta C.; Buigues E.D.D.L.L.; Gonzalez V.E.M.; Fuentes F.P.; Luciani A.A.
AUTHOR ADDRESSES
  (Ganuza J.R., fjromero@sescam.jccm.es; Forcada A.G.; Gambarrutta C.; Buigues 
E.D.D.L.L.; Gonzalez V.E.M.; Fuentes F.P.; Luciani A.A.) Intensive Care 
Unit, Internal Medicine Department, Paraplejics National Hospital, Toledo, 
Spain.
CORRESPONDENCE ADDRESS
  J. R. Ganuza, Intensive Care Unit, Internal Medicine Department, Paraplejics 
National Hospital, Toledo, Spain. Email: fjromero@sescam.jccm.es
FULL RECORD ENTRY DATE
  2011-04-01
SOURCE
  Journal of Spinal Cord Medicine (2011) 34:1 (76-84). Date of Publication: 
January 2011
VOLUME
  34
ISSUE
  1
FIRST PAGE
  76
LAST PAGE
  84
DATE OF PUBLICATION
  January 2011
ISSN
  1079-0268
BOOK PUBLISHER
  Maney Publishing, maney@maney.co.uk
ABSTRACT
  Objective: To assess the effect of timing and techniques of tracheostomy on 
morbidity, mortality, and the burden of resources in patients with acute 
traumatic spinal cord injuries (SCIs) undergoing mechanical ventilation. 
Design: Review of a prospectively collected database. Setting: Intensive and 
intermediate care units of a monographic hospital for the treatment of SCI. 
Participants: Consecutive patients admitted to the intensive care unit (ICU) 
during their first inpatient rehabilitation for cervical and thoracic 
traumatic SCI. A total of 323 patients were included: 297 required 
mechanical ventilation and 215 underwent tracheostomy. Outcome measures: 
Demographic data, data relevant to the patients' neurological injuries 
(level and grade of spinal cord damage), tracheostomy technique and timing, 
duration of mechanical ventilation, length of stay at ICU, incidence of 
pneumonia, incidence of perioperative and early postoperative complications, 
and mortality. Results: Early tracheostomy (<7 days after orotracheal 
intubation) tracheostomy was performed in 101 patients (47%) and late (≥7 
days) in 114 (53%). Surgical tracheostomy was employed in 119 cases (55%) 
and percutaneous tracheostomy in 96 (45%). There were 61 complications in 53 
patients related to all tracheostomy procedures. Two were qualified as 
serious (tracheoesophageal fistula and mediastinal abscess). Other 
complications were mild. Bleeding was moderate in one case (late, 
percutaneous tracheostomy). Postoperative infection rate was low. Mortality 
of all causes was also low. Conclusion: Early tracheostomy may have 
favorable effects in patients with acute traumatic SC. Both techniques, 
percutaneous and surgical tracheostomy, can be performed safely in the ICU. 
© The Academy for Spinal Cord Injury Professionals, Inc. 2011.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; spinal cord injury (surgery, therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; bleeding (complication); female; human; intensive care unit; length of stay; major clinical study; male; mediastinum disease (complication); morbidity; mortality; peroperative complication (complication); pneumonia (complication); postoperative complication (complication); postoperative infection (complication); tracheoesophageal fistula (complication); treatment duration; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011166880
MEDLINE PMID
  21528630 (http://www.ncbi.nlm.nih.gov/pubmed/21528630)
PUI
  L361497592
DOI
  10.1179/107902610X12886261091875
FULL TEXT LINK
  http://dx.doi.org/10.1179/107902610X12886261091875
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1179%2F107902610X12886261091875&atitle=Effect+of+technique+and+timing+of+tracheostomy+in+patients+with+acute+traumatic+spinal+cord+injury+undergoing+mechanical+ventilation&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=34&issue=1&spage=76&epage=84&aulast=Ganuza&aufirst=Javier+Romero&auinit=J.R.&aufull=Ganuza+J.R.&coden=JSCMC&isbn=&pages=76-84&date=2011&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 685
TITLE
  Incidence and clinical predictors for tracheostomy after cervical spinal 
cord injury: A national trauma databank review
AUTHOR NAMES
  Branco B.C.; Plurad D.; Green D.J.; Inaba K.; Lam L.; Cestero R.; Bukur M.; Demetriades D.
AUTHOR ADDRESSES
  (Branco B.C.; Plurad D., plurad@usc.edu; Green D.J.; Inaba K.; Lam L.; 
Cestero R.; Bukur M.; Demetriades D.) Division of Trauma and Surgical 
Critical Care, University of Southern California, Los Angeles, CA, United 
States.
CORRESPONDENCE ADDRESS
  D. Plurad, Navy Trauma Training Center, LAC + USC Medical Center, Division 
of Trauma and Surgical Critical Care, 1200 North State Street, Los Angeles, 
CA 90033, United States. Email: plurad@usc.edu
AiP/IP ENTRY DATE
  2010-06-19
FULL RECORD ENTRY DATE
  2011-02-03
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2011) 70:1 
(111-115). Date of Publication: January 2011
VOLUME
  70
ISSUE
  1
FIRST PAGE
  111
LAST PAGE
  115
DATE OF PUBLICATION
  January 2011
ISSN
  0022-5282
  1529-8809 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background: The purpose of this study was to determine the incidence and 
identify clinical predictors for the need for tracheostomy after cervical 
spinal cord injury (CSCI). Methods: The National Trauma Databank version 7.0 
(2002-2006) was used to identify all patients who sustained a CSCI. Patients 
with severe traumatic brain injury (TBI) were excluded. Demographics, 
clinical data, and outcomes were abstracted. Patients requiring tracheostomy 
were compared with those who did not require tracheostomy. Logistic 
regression analysis was used to identify independent predictors for the need 
of tracheostomy. Results: There were 5,265 eligible patients. Of these, 
1,082 (20.6%) required tracheostomy and 4,174 (79.4%) did not. The majority 
patients were men and blunt trauma predominated. Patients requiring 
tracheostomy had a higher Injury Severity Score (ISS) (33.5 ± 17.7 vs. 24.4 
± 16.2, p < 0.001) and required intubation more frequently on scene and 
Emergency Department (ED) (4.2 vs. 1.4%, p < 0.001 and 31.1 vs. 7.9%, p < 
0.001, respectively). Patients requiring tracheostomy had higher rates of 
complete CSCI at C1-C4 (18.2 vs. 8.4%, p < 0.001) and C5-C7 levels (37.8 vs. 
16.9%, p < 0.001). Patients requiring tracheostomy had more ventilation 
days, longer intensive care unit and hospital lengths of stay, but lower 
mortality. Intubation on scene or ED, complete CSCI at C1-C4 or C5-C7 
levels, ISS ≥16, facial fracture, and thoracic trauma were identified as 
independent predictors for the need of tracheostomy. Conclusion: After CSCI, 
a fifth of patients will require tracheostomy. Intubation on scene or ED, 
complete CSCI at C1-C4 or C5-C7 levels, ISS ≥16, facial fracture, and 
thoracic trauma were independently associated with the need for 
tracheostomy. Copyright © 2011 by Lippincott Williams &Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; face fracture; female; human; incidence; injury scale; intensive care unit; intubation; major clinical study; male; priority journal; thorax injury (surgery); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011044911
MEDLINE PMID
  20526209 (http://www.ncbi.nlm.nih.gov/pubmed/20526209)
PUI
  L50953907
DOI
  10.1097/TA.0b013e3181d9a559
FULL TEXT LINK
  http://dx.doi.org/10.1097/TA.0b013e3181d9a559
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:10.1097%2FTA.0b013e3181d9a559&atitle=Incidence+and+clinical+predictors+for+tracheostomy+after+cervical+spinal+cord+injury%3A+A+national+trauma+databank+review&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=70&issue=1&spage=111&epage=115&aulast=Branco&aufirst=Bernardino+C.&auinit=B.C.&aufull=Branco+B.C.&coden=JOTRF&isbn=&pages=111-115&date=2011&auinit1=B&auinitm=C
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 686
TITLE
  A second case of Marburg's variant of multiple sclerosis with vasculitis and 
extensive demyelination
AUTHOR NAMES
  Elenein R.G.A.; Sharer L.R.; Cook S.D.; Pachner A.R.; Michaels J.; Hillen M.E.
AUTHOR ADDRESSES
  (Elenein R.G.A., raniadml@yahoo.com) University of Medicine and Dentistry of 
New Jersey, New Jersey Medical School, Department of Neurology, 185 S. 
Orange Ave., MSB, H-506, NJ, United States.
(Sharer L.R.; Cook S.D.; Michaels J.; Hillen M.E.) University of Medicine 
and Dentistry of New Jersey, New Jersey Medical School, Department of 
Neurology and Neuroscience, United States.
(Pachner A.R.) University of Medicine and Dentistry of New Jersey, New 
Jersey Medical School, Department of Neurosciences, United States.
CORRESPONDENCE ADDRESS
  R.G.A. Elenein, University of Medicine and Dentistry of New Jersey, New 
Jersey Medical School, Department of Neurology, 185 S. Orange Ave., MSB, 
H-506, NJ, United States. Email: raniadml@yahoo.com
FULL RECORD ENTRY DATE
  2011-12-08
SOURCE
  Multiple Sclerosis Journal (2011) 17:12 (1531-1538). Date of Publication: 
December 2011
VOLUME
  17
ISSUE
  12
FIRST PAGE
  1531
LAST PAGE
  1538
DATE OF PUBLICATION
  December 2011
ISSN
  1477-0970 (electronic)
  1352-4585
BOOK PUBLISHER
  info@sagepub.co.uk
ABSTRACT
  Marburg's variant of multiple sclerosis is a rapidly progressive and 
malignant form of multiple sclerosis (MS) that usually leads to severe 
disability or death within weeks to months without remission. Few cases have 
been described in the literature since the original description by Marburg. 
The classic pathological findings usually include highly destructive zones 
of extensive demyelination, necrosis with dense cellular infiltrate, and 
giant reactive astrocytes. We report a case of a 31-year-old woman with 
Marburg's variant of MS who, over a period of eight months, became totally 
disabled, blind, and quadriplegic, with vocal cord paralysis, requiring a 
tracheostomy. The patient underwent diagnostic stereotactic brain biopsy. 
Clinical findings, magnetic resonance imaging (MRI), serologic and 
cerebrospinal fluid (CSF) findings, and neuropathology are discussed. MRI 
showed extensive white matter involvement in the brain and spinal cord that 
continuously progressed over time. A diagnostic stereotactic brain biopsy 
revealed extensive active demyelination with unexpected finding of active 
vasculitis and fibrinoid necrosis with a vascular inflammatory cell 
infiltrate, including polymorphonuclear neutrophils and rare eosinophils. 
Serologic work-up for vasculitis and neuromyelitis optica was unremarkable 
and the CSF showed only one oligoclonal band (OCB) not present in serum. 
This is the second case of Marburg's variant of MS that demonstrated both 
demyelination and vasculitis. In our case these features were demonstrated 
simultaneously, even though the demyelination was the predominant 
pathological finding. Since vasculitis is not a feature of classic MS, these 
findings pose the question as to whether Marburg's variant of MS is a true 
variant or different entity altogether. © SAGE Publications 2011.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  multiple sclerosis (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; cerebrospinal fluid analysis; clinical feature; demyelination (diagnosis); disability; female; human; nuclear magnetic resonance imaging; serology; stereotactic biopsy; tracheostomy; vasculitis (diagnosis); vocal cord paralysis; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011661102
MEDLINE PMID
  21816761 (http://www.ncbi.nlm.nih.gov/pubmed/21816761)
PUI
  L363022249
DOI
  10.1177/1352458511414042
FULL TEXT LINK
  http://dx.doi.org/10.1177/1352458511414042
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14770970&id=doi:10.1177%2F1352458511414042&atitle=A+second+case+of+Marburg%27s+variant+of+multiple+sclerosis+with+vasculitis+and+extensive+demyelination&stitle=Mult.+Scler.+J.&title=Multiple+Sclerosis+Journal&volume=17&issue=12&spage=1531&epage=1538&aulast=Elenein&aufirst=Rania+G.A.&auinit=R.G.A.&aufull=Elenein+R.G.A.&coden=MUSCF&isbn=&pages=1531-1538&date=2011&auinit1=R&auinitm=G.A.
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 687
TITLE
  Dysphagia in individuals with tetraplegia: Incidence and risk factors
AUTHOR NAMES
  Shem K.; Castillo K.; Wong S.; Chang J.
AUTHOR ADDRESSES
  (Shem K., kazuko.shem@hhs.sccgov.org) Department of PM and R, Santa Clara 
Valley Medical Center, 751 South Bascom Ave., San Jose, CA 95128, United 
States.
(Castillo K.) Department of Therapy Services, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
(Wong S.) Department of Respiratory Therapy, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
(Chang J.) Rehabilitation Research Center, Santa Clara Valley Medical 
Center, San Jose, CA, United States.
CORRESPONDENCE ADDRESS
  K. Shem, Department of PM and R, Santa Clara Valley Medical Center, 751 
South Bascom Ave., San Jose, CA 95128, United States. Email: 
kazuko.shem@hhs.sccgov.org
FULL RECORD ENTRY DATE
  2011-04-01
SOURCE
  Journal of Spinal Cord Medicine (2011) 34:1 (85-92). Date of Publication: 
January 2011
VOLUME
  34
ISSUE
  1
FIRST PAGE
  85
LAST PAGE
  92
DATE OF PUBLICATION
  January 2011
ISSN
  1079-0268
BOOK PUBLISHER
  Maney Publishing, maney@maney.co.uk
ABSTRACT
  Background/objective: Dysphagia following cervical spinal cord injury (SCI) 
can increase risk for pulmonary complications that may delay the 
rehabilitative process. The objective of this study was to identify risk 
factors for dysphagia after cervical SCI. Design: Prospective cohort study. 
Methods: Individuals with cervical SCI within 31 days of injury underwent a 
bedside swallow evaluation (BSE) followed by a videofluoroscopy swallow 
study (VFSS) within 72 hours of the BSE. Subjects were diagnosed as having 
dysphagia if they had positive findings in either BSE or VFSS. Results: 
Twenty-nine patients (7 female and 22 male) were enrolled. Of these, 21 
(72%) had high cervical tetraplegia (C4 or higher) and 8 (38%) had lower 
cervical tetraplegia. A tracheostomy was present in 18 (62%) patients; 15 
(52%) subjects were on ventilators. Dysphagia was diagnosed in 12 (41%) 
subjects. Dysphagia was noted in 62% of the subjects with tracheostomy and 
53% of the subjects on the ventilator, but only tracheostomy resulted in a 
statistically significant association with dysphagia (P = 0.047). All three 
subjects who had nasogastric tubes were diagnosed with dysphagia (P = 
0.029). The relationships between dysphagia and gender, high versus low 
tetraplegia, presence of halo or collar, head injury, and ventilator use 
were not statistically significant, but age was a significant risk factor (P 
= 0.028). Conclusions: Dysphagia is present in about 41% of individuals with 
acute tetraplegia. Only age, tracheostomy, and nasogastric tubes were 
identified as significant risk factors for dysphagia for individuals with 
tetraplegia. No relationship between dysphagia and level of SCI, spine 
surgery, collar, and ventilator use was found to exist. © The Academy for 
Spinal Cord Injury Professionals, Inc. 2011.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (diagnosis, etiology, surgery); quadriplegia; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cervical spine; cervical spine injury; clinical article; cohort analysis; controlled study; disease association; female; fluoroscopy; head injury; human; incidence; male; nasogastric tube; prospective study; risk factor; spinal cord injury; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011166881
MEDLINE PMID
  21528631 (http://www.ncbi.nlm.nih.gov/pubmed/21528631)
PUI
  L361497593
DOI
  10.1179/107902610X12911165974981
FULL TEXT LINK
  http://dx.doi.org/10.1179/107902610X12911165974981
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1179%2F107902610X12911165974981&atitle=Dysphagia+in+individuals+with+tetraplegia%3A+Incidence+and+risk+factors&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=34&issue=1&spage=85&epage=92&aulast=Shem&aufirst=Kazuko&auinit=K.&aufull=Shem+K.&coden=JSCMC&isbn=&pages=85-92&date=2011&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 688
TITLE
  The acute respiratory management of cervical spinal cord injury in the first 
6 weeks after injury: A systematic review
AUTHOR NAMES
  Berney S.; Bragge P.; Granger C.; Opdam H.; Denehy L.
AUTHOR ADDRESSES
  (Berney S., sue.berney@austin.org.au; Granger C.) Physiotherapy Department, 
Austin Hospital, Melbourne, VIC, Australia.
(Bragge P.) National Trauma Research Institute, Monash University, 
Melbourne, VIC, Australia.
(Opdam H.) Department of Intensive Care, Austin Hospital, Melbourne, VIC, 
Australia.
(Denehy L.) School of Health Sciences, University of Melbourne, Parkville, 
VIC, Australia.
CORRESPONDENCE ADDRESS
  S. Berney, C/O Physiotherapy Level 3 HSB, Austin Hospital, 145 Studley Road, 
Melbourne, VIC 3084, Australia. Email: sue.berney@austin.org.au
AiP/IP ENTRY DATE
  2010-04-22
FULL RECORD ENTRY DATE
  2011-01-31
SOURCE
  Spinal Cord (2011) 49:1 (17-29). Date of Publication: January 2011
VOLUME
  49
ISSUE
  1
FIRST PAGE
  17
LAST PAGE
  29
DATE OF PUBLICATION
  January 2011
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Systematic review.Objectives: Identify, evaluate, and 
synthesize evidence regarding the effectiveness of various treatment 
strategies for the respiratory management of acute tetraplegia.Setting: 
Melbourne, Australia.Methods: A search of multiple electronic databases 
(Medline, Cinahl, EMBASE, Cochrane Library, Web of Science, 
http://www.guideline.gov and http://www.icord.org/scire) was undertaken 
accompanied by the reference lists of all relevant articles identified. 
Methodological quality was assessed using the Newcastle-Ottawa Scale and the 
PEDro Scale. Descriptive analysis was performed.Results: Twenty-one studies 
including 1263 patients were identified. The majority of the studies were 
case series (n=13). A variety of interventions were used for the management 
of respiratory complications. Mortality (ARR0.4, 95% confidence interval 
(CI) 0.18, 0.61), the incidence of respiratory complications (ARR0.36, 95% 
CI (0.08, 0.58)), and requirement for a tracheostomy (ARR0.18, 95% CI (0.05, 
0.4)) were significantly reduced by using a respiratory protocol. A clinical 
pathway reduced duration of mechanical ventilation by 6 days 95% CI (0.56, 
12.56), intensive care unit length of stay by 6.8 days 95% CI (0.17-13.77) 
and costs. Intubation, mechanical ventilation, and tracheostomy are the 
mainstay of respiratory management for complete injuries above the level of 
C5.Conclusion: This review showed a clinical pathway with a structured 
respiratory protocol that includes a combination of treatment techniques 
provided regularly is effective in reducing respiratory complications and 
cost. The overall study quality was moderate and further studies using 
specific interventions that target respiratory complications are associated 
with specific regions of the cervical spine using more methodologically 
rigorous designs are required. © 2011 International Spinal Cord Society All 
rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury; emergency care; intubation; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  atelectasis; case study; Cinahl; Cochrane Library; descriptive research; Embase; hospital cost; human; intensive care unit; Medline; methodology; mortality; pneumonia; priority journal; quadriplegia; quality control; respiratory failure; respiratory tract infection; review; systematic review; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011026180
MEDLINE PMID
  20404832 (http://www.ncbi.nlm.nih.gov/pubmed/20404832)
PUI
  L50880664
DOI
  10.1038/sc.2010.39
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2010.39
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2010.39&atitle=The+acute+respiratory+management+of+cervical+spinal+cord+injury+in+the+first+6+weeks+after+injury%3A+A+systematic+review&stitle=Spinal+Cord&title=Spinal+Cord&volume=49&issue=1&spage=17&epage=29&aulast=Berney&aufirst=S.&auinit=S.&aufull=Berney+S.&coden=SPCOF&isbn=&pages=17-29&date=2011&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 689
TITLE
  Cerebellar hemorrhage after spine fixation misdiagnosed as a complication of 
narcotics use - A case report
AUTHOR NAMES
  Yang K.-H.; Han J.U.; Jung J.-K.; Lee D.I.; Hwang S.-I.; Lim H.K.
AUTHOR ADDRESSES
  (Yang K.-H.; Han J.U.; Jung J.-K.; Lee D.I.; Hwang S.-I.; Lim H.K., 
hkliman@inha.ac.kr) Department of Anesthesiology and Pain Medicine, Inha 
University Hospital, Inha University College of Medicine, 7-206, 
Sinheung-dong 3-ga, Jung-gu, Incheon 400-711, South Korea.
CORRESPONDENCE ADDRESS
  H. K. Lim, Department of Anesthesiology and Pain Medicine, Inha University 
Hospital, Inha University College of Medicine, 7-206, Sinheung-dong 3-ga, 
Jung-gu, Incheon 400-711, South Korea. Email: hkliman@inha.ac.kr
AiP/IP ENTRY DATE
  2011-03-07
FULL RECORD ENTRY DATE
  2011-03-09
SOURCE
  Korean Journal of Anesthesiology (2011) 60:1 (54-56). Date of Publication: 
January 2011
VOLUME
  60
ISSUE
  1
FIRST PAGE
  54
LAST PAGE
  56
DATE OF PUBLICATION
  January 2011
ISSN
  2005-6419
  2005-7563 (electronic)
BOOK PUBLISHER
  Korean Society of Anesthesiologists, 314-1,2-Ga Hangangro, Yongsan-gu, 
Seoul, South Korea.
ABSTRACT
  Cerebellar hemorrhage occurs mainly due to hypertension. Postoperative 
cerebellar hemorrhage is known to be associated frequently with 
frontotemporal craniotomy, but quite rare with spine operation. A 
56-year-old female received spinal fixation due to continuous leg tingling 
sensation for since two years ago. Twenty-one hours after operation, she was 
disoriented and unresponsive to voice. Performed computed tomography showed 
both cerebellar hemorrhage. An emergency decompressive craniotomy was 
carried out to remove the hematoma. On the basis of this case, we reported 
this complications and reviewed related literature. Copyright © the Korean 
Society of Anesthesiologists, 2011.
EMTREE DRUG INDEX TERMS
  fentanyl (adverse drug reaction); metoclopramide (drug therapy, intravenous drug administration); ondansetron (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cerebellum hemorrhage (complication, diagnosis, surgery); diagnostic error; sensory dysfunction (surgery); spine stabilization; 
EMTREE MEDICAL INDEX TERMS
  adult; aphasia (complication); article; ataxia (complication); case report; computer assisted tomography; consciousness; craniotomy; disorientation; drug withdrawal; female; hematoma; human; intracranial pressure; lethargy (side effect); nausea (drug therapy, side effect); patient controlled analgesia; tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  metoclopramide (12707-59-4, 2576-84-3, 364-62-5, 7232-21-5)
  ondansetron (103639-04-9, 116002-70-1, 99614-01-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011108028
PUI
  L361312136
DOI
  10.4097/kjae.2011.60.1.54
FULL TEXT LINK
  http://dx.doi.org/10.4097/kjae.2011.60.1.54
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=20056419&id=doi:10.4097%2Fkjae.2011.60.1.54&atitle=Cerebellar+hemorrhage+after+spine+fixation+misdiagnosed+as+a+complication+of+narcotics+use+-+A+case+report&stitle=Korean+J.+Anesth.&title=Korean+Journal+of+Anesthesiology&volume=60&issue=1&spage=54&epage=56&aulast=Yang&aufirst=Ki-Hwan&auinit=K.-H.&aufull=Yang+K.-H.&coden=&isbn=&pages=54-56&date=2011&auinit1=K&auinitm=-H
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 690
TITLE
  Predisposing factors for serum sodium disturbance in patients with severe 
traumatic brain injury (SBI)
AUTHOR NAMES
  Abrishamkar S.; Safavi M.; Tavakoli P.; Moradi D.; Honarmand A.
AUTHOR ADDRESSES
  (Abrishamkar S.; Tavakoli P.) Department of Neurosurgery and Intensive Care 
unit, Isfahan University of Medical Sciences, Isfahan, Iran.
(Safavi M., safavi@med.mui.ac.ir; Moradi D.; Honarmand A.) Department of 
Anesthesiology and Intensive Care Unit, Isfahan University of Medical 
Sciences, Isfahan, Iran.
CORRESPONDENCE ADDRESS
  M. Safavi, Department of Anesthesiology and Intensive Care Unit, Isfahan 
University of Medical Sciences, Isfahan, Iran. Email: safavi@med.mui.ac.ir
AiP/IP ENTRY DATE
  2011-03-09
FULL RECORD ENTRY DATE
  2011-03-16
SOURCE
  Turkish Journal of Medical Sciences (2010) 40:6 (851-855). Date of 
Publication: 2010
VOLUME
  40
ISSUE
  6
FIRST PAGE
  851
LAST PAGE
  855
DATE OF PUBLICATION
  2010
ISSN
  1300-0144
BOOK PUBLISHER
  Turkiye Klinikleri Journal of Medical Sciences, Talapapa Bulvary no. 102, 
Hamammonu, Turkey.
ABSTRACT
  Aim: Disturbances in the plasma sodium level in patients with severe brain 
injury (SBI) is not a rare phenomenon and may cause adverse effects on 
prognosis and treatment outcomes. The knowledge of the prevalence of risk 
factors helps in early detection and good management of the serum sodium 
level disturbance. Materials and methods: This is a prospective clinical 
trial double blind study. The target population included patients with SBI 
who had disturbances in their plasma sodium level and were admitted at the 
ICU of Kashani Hospital Isfahan Iran between January and October 2006. The 
patients with renal insufficiency diuretic therapy massive transfusion brain 
death and spinal cord injury were excluded. Gender age the prevalence of 
hypo- and hypernatremia having tracheal tube or tracheostomy requiring 
mechanical ventilation support craniotomy type of intracranial pathology 
positive history of cardiopulmonary disease the mean time after which the 
disturbance occurs and the mean time needed for the recovery from the 
disturbance were studied. Results: The prevalence of hypo- and hypernatremia 
were 60% and 40% respectively. Most of the patients were 21-50- year-old 
males with craniotomy. The mean time after which the disturbance occurs was 
23 days after head trauma and the mean time needed for the recovery from 
sodium level disturbances was 11.5 days. Conclusion: Hypo- and hypernatremia 
are common complications of intracranial lesions. Early detection of serum 
sodium level disturbance is important in these patients and appropriate 
treatment may actually improve prognosis. © TÜBİTAK.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  sodium ion (endogenous compound); 
EMTREE DRUG INDEX TERMS
  glucose (endogenous compound); sodium chloride (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  disease predisposition; electrolyte disturbance; traumatic brain injury; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; arterial oxygen saturation; article; artificial ventilation; blood pressure measurement; body temperature measurement; brain edema; cardiopulmonary insufficiency; central pontine myelinolysis; clinical article; convalescence; craniotomy; disease management; early diagnosis; end tidal carbon dioxide tension; endotracheal tube; female; glucose blood level; head injury; human; hypernatremia; hyponatremia (drug therapy); injury severity; intracranial pressure monitoring; male; prevalence; prognosis; prospective study; risk factor; sodium blood level; time; tracheostomy; treatment outcome; 
CAS REGISTRY NUMBERS
  glucose (50-99-7, 84778-64-3)
  sodium chloride (7647-14-5)
  sodium ion (17341-25-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011122073
PUI
  L361354698
DOI
  10.3906/sag-0908-202
FULL TEXT LINK
  http://dx.doi.org/10.3906/sag-0908-202
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13000144&id=doi:10.3906%2Fsag-0908-202&atitle=Predisposing+factors+for+serum+sodium+disturbance+in+patients+with+severe+traumatic+brain+injury+%28SBI%29&stitle=Turk.+J.+Med.+Sci.&title=Turkish+Journal+of+Medical+Sciences&volume=40&issue=6&spage=851&epage=855&aulast=Abrishamkar&aufirst=Saeid&auinit=S.&aufull=Abrishamkar+S.&coden=TJMEE&isbn=&pages=851-855&date=2010&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 691
TITLE
  Cardiac pacing in patients with a cervical spinal cord injury
AUTHOR NAMES
  Rangappa P.; Jeyadoss J.; Flabouris A.; Clark J.M.; Marshall R.
AUTHOR ADDRESSES
  (Rangappa P.) Columbia Asia Hospital, Bangalore, Karnataka, India.
(Jeyadoss J.) Department of Anaesthesia, Queen Elizabeth Hospital, 
Woodville, SA, Australia.
(Flabouris A., Arthas.Flabouris@health.sa.gov.au) Intensive Care Unit, Royal 
Adelaide Hospital, University of Adelaide, North Tce, Adelaide 5000, SA, 
Australia.
(Clark J.M.) South Australian Spinal Cord Injury Research Centre, Hampstead 
Rehabilitation Centre, Northfield, SA, Australia.
(Marshall R.) South Australian Spinal Cord Injury Service, Royal Adelaide 
Hospital, Adelaide, SA, Australia.
CORRESPONDENCE ADDRESS
  A. Flabouris, Intensive Care Unit, Royal Adelaide Hospital, University of 
Adelaide, North Tce, Adelaide 5000, SA, Australia. Email: 
Arthas.Flabouris@health.sa.gov.au
AiP/IP ENTRY DATE
  2010-05-27
FULL RECORD ENTRY DATE
  2010-12-22
SOURCE
  Spinal Cord (2010) 48:12 (867-871). Date of Publication: December 2010
VOLUME
  48
ISSUE
  12
FIRST PAGE
  867
LAST PAGE
  871
DATE OF PUBLICATION
  December 2010
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Retrospective medical record review. Objectives: To compare 
patients, admitted to an intensive care unit (ICU) with an acute cervical 
spinal cord injury (SCI) and documented motor deficit, who did, with those 
who did not, require a cardiac pacemaker. Setting: South Australian Tertiary 
Referral Intensive Care and Spinal Injury Unit. Methods: Retrospective 
medical record review and data set linkage. Results: From 1995 to 2007, 465 
patients sustained a cervical SCI. Of these, 30 (6.5%) were admitted to ICU 
with a clinically assessable motor deficit and 3 (0.6% of all patients, or 
10% of those admitted to ICU) required a cardiac pacemaker. All three 
patients had a cervical SCI, C5 (American Spinal Injury Association A) 
tetraplegia, and required invasive mechanical respiratory and inotropic 
support and a tracheostomy for weaning. Two patients (66%) were discharged 
alive to rehabilitation. Patients requiring a pacemaker had bradycardic 
episodes over a longer period (11 vs 4 days, P=0.01), a trend towards a 
later onset of bradycardia (8 vs 1.5 days, P=0.05) and a longer ICU length 
of stay (37 vs 10 days, P=0.02). Conclusion: Patients with a cervical SCI 
requiring a cardiac pacemaker are characterized by a higher level of SCI 
injury and motor loss, require mechanical respiratory and inotropic support, 
a tracheostomy to wean, and bradycardic episodes of a later onset and over a 
longer period of time. These findings suggest that such patients should be 
managed at hospitals with specialized acute spinal injury, intensive care 
and cardiac pacemaker services. © 2010 International Spinal Cord Society All 
rights reserved.
EMTREE DRUG INDEX TERMS
  atropine (drug therapy, intravenous drug administration); inotropic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial heart pacemaker; bradycardia (drug therapy, drug therapy, therapy); cervical spinal cord injury (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; female; heart pacing; human; intensive care unit; length of stay; major clinical study; male; medical record review; oxygen therapy; priority journal; quadriplegia; rehabilitation care; retrospective study; tertiary health care; tracheostomy; 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Rehabilitation and Physical Medicine (19)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010664910
MEDLINE PMID
  20498664 (http://www.ncbi.nlm.nih.gov/pubmed/20498664)
PUI
  L50926941
DOI
  10.1038/sc.2010.48
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2010.48
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2010.48&atitle=Cardiac+pacing+in+patients+with+a+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=48&issue=12&spage=867&epage=871&aulast=Rangappa&aufirst=P.&auinit=P.&aufull=Rangappa+P.&coden=SPCOF&isbn=&pages=867-871&date=2010&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 692
TITLE
  Acute airway obstruction associated with the use of bone-morphogenetic 
protein in cervical spinal fusion
AUTHOR NAMES
  Yaremchuk K.; Toma M.; Somers M.
AUTHOR ADDRESSES
  (Yaremchuk K.; Somers M.) Henry Ford Health System, Department of 
Otolaryngology - Head and Neck Surgery, Detoit, MI, United States.
(Toma M.) Wayne State University - School of Medicine, Detroit, MI, United 
States.
CORRESPONDENCE ADDRESS
  K. Yaremchuk, Henry Ford Health System, Department of Otolaryngology - Head 
and Neck Surgery, Detoit, MI, United States.
AiP/IP ENTRY DATE
  2011-01-24
FULL RECORD ENTRY DATE
  2011-02-08
SOURCE
  Laryngoscope (2010) 120:SUPPL. 4 (S140). Date of Publication: 2010
VOLUME
  120
ISSUE
  SUPPL. 4
DATE OF PUBLICATION
  2010
ISSN
  0023-852X
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Objectives: Bone morphogenetic protein (BMP) used in anterior cervical 
spinal fusion procedures causes an inflammatory response resulting in upper 
airway obstruction between postoperative days 4-7. The purpose of this study 
is to determine the incidence and severity of airway complications 
associated with use of BMP, the associated clinical outcomes, morbidities 
and mortalities following its use, and to create a clinical awareness of 
patients with acute airway obstruction associated with the use of BMP in 
cervical spinal fusion. Methods: This is a retrospective study of 260 
patients who underwent cervical spinal fusion procedures with BMP from 
2004-2009 and 520 patients, matched on procedure, who underwent cervical 
spinal fusion procedures without BMP during the same period at a tertiary 
care center. The two groups were compared on multiple outcome variables: 
hospital length of stay (LOS), costs, incidence of airway obstruction, 
unplanned intubations after surgery, tracheotomies, intensive care unit 
(ICU) admissions, hoarseness, dyspnea, respiratory failure, dysphasia and 
dysphagia, readmissions, and need for percutaneous endoscopic gastrostomy 
(PEG) tubes. All outcome variables that were binary in nature were analyzed 
using linear logistic regression analyses predicting use of BMP. Deaths up 
to 90 days post surgery were analyzed with a Cox proportional hazards model. 
Variables significantly related to BMP use were used as covariates in the 
above analyses. Results: Patients that underwent cervical procedures with 
BMP were noted to have significantly longer hospital stays (7.2 ± 11.1 days 
vs. 4.3 ± 5.2 days, p < 0.001), and greater costs ($129,483 versus $74,974, 
p < 0.001) than the control group (Table 1). Tracheotomies (Odds Ratio = 
3.79, p-value = 0.021), unplanned intubations after surgery (2.81, 0.008), 
dysphagia (8.94, 0.001), dyspnea (2.43, 0.001), and respiratory failure 
(3.35, 0.001) were all significantly associated with the BMP group (Table 2 
& Figure 1). In addition, hospital readmissions (1.96, 0.040), ICU 
admissions (3.05, 0.001), and 90 day mortality rates (Hazard Ratio = 2.44, p 
= 0.047) were significantly worse for the BMP group. Conclusions: Acute 
airway obstruction in the postoperative period following cervical spine 
fusion using BMP is a complication of its use. Due to the degree of 
obstruction and difficulty with intubation postoperatively, a clinical 
awareness is necessary to effectively manage these patients. Collaborative 
efforts between the spine surgeon, anesthesia and the otolaryngologist are 
required for management of the complications that occur after surgery. © 
2010 The American Laryngological, Rhinological, and Otological Society, 
Inc..
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  recombinant bone morphogenetic protein 2 (adverse drug reaction); 
EMTREE DRUG INDEX TERMS
  infuse; unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (side effect, complication, side effect); anterior spine fusion; bone graft; 
EMTREE MEDICAL INDEX TERMS
  case control study; computer assisted tomography; conference paper; controlled study; disease association; disease severity; dysphagia (complication); dysphasia (complication); dyspnea (complication); hoarseness (complication); hospital readmission; hospitalization cost; human; intensive care unit; intubation; length of stay; major clinical study; mortality; outcome assessment; percutaneous endoscopic gastrostomy; postoperative period; prediction; priority journal; respiratory failure (complication); retrospective study; tertiary health care; tracheotomy; treatment outcome; 
DRUG TRADE NAMES
  infuse  , United StatesMedtronic

DRUG MANUFACTURERS
   (United States)Medtronic
DEVICE TRADE NAMES
  INFUSE  , United StatesMedtronic

DEVICE MANUFACTURERS
   (United States)Medtronic
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011033572
MEDLINE PMID
  21225738 (http://www.ncbi.nlm.nih.gov/pubmed/21225738)
PUI
  L361108967
DOI
  10.1002/lary.21604
FULL TEXT LINK
  http://dx.doi.org/10.1002/lary.21604
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0023852X&id=doi:10.1002%2Flary.21604&atitle=Acute+airway+obstruction+associated+with+the+use+of+bone-morphogenetic+protein+in+cervical+spinal+fusion&stitle=Laryngoscope&title=Laryngoscope&volume=120&issue=SUPPL.+4&spage=&epage=&aulast=Yaremchuk&aufirst=Kathleen&auinit=K.&aufull=Yaremchuk+K.&coden=LARYA&isbn=&pages=-&date=2010&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 693
TITLE
  Early and late results of descending thoracic and thoracoabdominal aortic 
aneurysm open repair with deep hypothermia and circulatory arrest
AUTHOR NAMES
  Fehrenbacher J.W.; Siderys H.; Terry C.; Kuhn J.; Corvera J.S.
AUTHOR ADDRESSES
  (Fehrenbacher J.W.; Siderys H.; Kuhn J.; Corvera J.S., jcorvera@clarian.org) 
Clarian Cardiovascular Surgeons, Methodist Hospital, Indianapolis, IN, 
United States.
(Terry C.) Methodist Research Institute, Methodist Hospital, Indianapolis, 
IN, United States.
CORRESPONDENCE ADDRESS
  J. S. Corvera, Clarian Cardiovascular Surgeons, 1801 N Senate Blvd, 
Indianapolis, IN 46202, United States. Email: jcorvera@clarian.org
AiP/IP ENTRY DATE
  2010-11-30
FULL RECORD ENTRY DATE
  2010-12-02
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (2010) 140:6 SUPPL. 
(S154-S160). Date of Publication: December 2010
VOLUME
  140
ISSUE
  6 SUPPL.
DATE OF PUBLICATION
  December 2010
ISSN
  0022-5223
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  Objective: Open repair of descending thoracic aortic and thoracoabdominal 
aortic aneurysms may carry low morbidity and mortality, depending on 
experience of the surgeon and operative technique used. Although thoracic 
endovascular aortic repair is less invasive, its limitations include anatomy 
and pathology of the aorta, proximity of major branches, and significant 
complication and reintervention rates. We retrospectively reviewed a 
2-surgeon experience (J.W.F. and J.S.C.) with deep hypothermic circulatory 
arrest to repair descending thoracic aortic and thoracoabdominal aortic 
aneurysms. Methods: All patients (n = 343) who underwent surgical 
replacement of descending thoracic aortic or thoracoabdominal aortic 
aneurysm with deep hypothermic circulatory arrest from 1995 to 2009 were 
included. Segmental arteries between T8 and the celiac artery were 
aggressively reimplanted as indicated. Visceral and renal artery bypasses 
were performed for significant stenosis. Concomitant coronary artery bypass 
grafting was performed if targets were anterior or lateral wall vessels. 
Lumbar drains were not routinely used but placed postoperatively on clinical 
evidence of spinal cord ischemia. Results: Of 343 patients, 98 had 
descending thoracic aortic aneurysms, 69 had Crawford type I 
thoracoabdominal aortic aneurysms, 111 had type II, 32 had type III, and 33 
had type IV. Emergency or urgent operations comprised 13% of repairs. 
Hospital mortalities were 5.0% for all cases, 3.7% for elective cases, and 
13.3% for urgent or emergency cases. Overall incidences were 4.4% for 
stroke, 3.2% for paraplegia or paraparesis, 1.5% for renal failure requiring 
dialysis, and 3.5% for tracheostomy. The 1-, 3-, 5-, and 10-year survival 
rates were 90%, 79%, 69%, and 54%, respectively. Conclusions: Surgical 
repair of descending thoracic aortic and thoracoabdominal aortic aneurysms 
with deep hypothermic circulatory arrest carries low operative morbidity and 
mortality and excellent early and late survival rates. These results can be 
used as a benchmark for future techniques and technologies. Copyright © 2010 
by The American Association for Thoracic Surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal aortic aneurysm (surgery); deep hypothermic circulatory arrest; descending aortic surgery; thoracic aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; cerebrovascular accident; conference paper; coronary artery bypass graft; dialysis; female; human; kidney failure; major clinical study; male; morbidity; paraplegia; postoperative period; priority journal; spinal cord ischemia (complication); stenosis; surgical mortality; surgical technique; survival; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010636403
MEDLINE PMID
  21092785 (http://www.ncbi.nlm.nih.gov/pubmed/21092785)
PUI
  L359996483
DOI
  10.1016/j.jtcvs.2010.08.054
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtcvs.2010.08.054
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225223&id=doi:10.1016%2Fj.jtcvs.2010.08.054&atitle=Early+and+late+results+of+descending+thoracic+and+thoracoabdominal+aortic+aneurysm+open+repair+with+deep+hypothermia+and+circulatory+arrest&stitle=J.+Thorac.+Cardiovasc.+Surg.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=140&issue=6+SUPPL.&spage=&epage=&aulast=Fehrenbacher&aufirst=John+W.&auinit=J.W.&aufull=Fehrenbacher+J.W.&coden=JTCSA&isbn=&pages=-&date=2010&auinit1=J&auinitm=W
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 694
TITLE
  Extubation failure in patients with primary brain injury
AUTHOR NAMES
  Karanjia N.; Nordquist D.; Stevens R.; Nyquist P.
AUTHOR ADDRESSES
  (Karanjia N.; Nyquist P.) Johns Hopkins Hospital, United States.
(Nordquist D.) Westchester Medical Center, United States.
(Stevens R.) Johns Hopkins University, School of Medicine, United States.
CORRESPONDENCE ADDRESS
  N. Karanjia, Johns Hopkins Hospital, United States.
FULL RECORD ENTRY DATE
  2011-01-04
SOURCE
  Critical Care Medicine (2010) 38 SUPPL. 12 (A191). Date of Publication: 
December 2010
VOLUME
  38
FIRST PAGE
  A191
DATE OF PUBLICATION
  December 2010
CONFERENCE NAME
  40th Critical Care Congress of the Society of Critical Care Medicine
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2011-01-15 to 2011-01-19
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Patients with acute brain injury but normal lung function are 
often intubated for airway protection. Extubation often fails. Currently, no 
clinical data exist that describe the events leading to extubation failure 
and reintubation in this population. Hypothesis: Our objective was to 
identify the clinical characteristics of patients for whom extubation failed 
whose primary reason for intubation was a primary brain injury independent 
of mechanical lung injury. We also identified the extubation failure rate, 
reintubation rate, and clinical characteristics of these patients. Our 
primary hyopthesis was that causes other than aspiration and or pneumonia 
would be the main reason for reintubation. Methods: Retrospective review of 
electronic databases supplemented by chart review from January 2002 to March 
2007. Results: Patients admitted to the neurocritical care unit who were 
intubated because of primary neurological injury of brain, spinal cord, or 
peripheral nerve numbered 1265. Of these, 25 (2%) died before extubation and 
767 (61%) were extubated. The number of patients extubated to comfort care 
was 292 (23%). Tracheostomies were placed in 181 (14%) patients, of which, 
77 (5.9%) were attempted before extubation. A total of 129 (10%) patients 
were reintubated; 77 (5.9% ) met the clinical definition of extubation 
failure. Ninety-nine of the patients reintubated had encephalopathy that 
resulted from primary brain injury. Of these, 12 (12%) had a documented 
pneumonia, six (6%) aspirated, six (6%) experienced stridor, and 17 (17%) 
experienced a medical emergency. The most common clinical scenario leading 
to reintubation was respiratory distress with altered mental status [59 
patients (59%)]; these patients usually suffered from atelectasis and 
decreased minute ventilation, independent of fever, pneumonia, aspiration, 
and increased work of breathing [39 patients (39%)]. Conclusions: The 
extubation failure rate in our neurocritical care unit is low. In patients 
with primary brain injury who were intubated, atelectasis and decreased 
minute ventilation were the most common causes for reintubation. Aspiration 
and pneumonia were not the most common reason for reintubation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; extubation; intensive care; patient; society; 
EMTREE MEDICAL INDEX TERMS
  airway; aspiration; aspiration pneumonia; atelectasis; brain; brain disease; clinical study; data base; emergency; fever; hypothesis; injury; intubation; lung function; lung function test; lung injury; lung minute volume; medical record review; mental health; peripheral nerve; pneumonia; population; protection; respiratory distress; spinal cord; stridor; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70317868
DOI
  10.1097/01.ccm.0000390903.16849.8c
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000390903.16849.8c
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000390903.16849.8c&atitle=Extubation+failure+in+patients+with+primary+brain+injury&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=38&issue=&spage=A191&epage=&aulast=Karanjia&aufirst=Navaz&auinit=N.&aufull=Karanjia+N.&coden=&isbn=&pages=A191-&date=2010&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 695
TITLE
  [Preferable surgical approaches to the aortic root-arch in patients with 
functioning tracheostomy].
AUTHOR NAMES
  Nakayama T.; Kanou M.; Isshiki S.; Sasaki H.; Tominaga T.; Ishitoya H.; Kurobe H.; Kitagawa T.; Hiratani K.; Hori T.
AUTHOR ADDRESSES
  (Nakayama T.) Division of Cardiovascular Surgery, Ehime Prefetural Central 
Hospital, Matsuyama, Japan.
(Kanou M.; Isshiki S.; Sasaki H.; Tominaga T.; Ishitoya H.; Kurobe H.; 
Kitagawa T.; Hiratani K.; Hori T.)
CORRESPONDENCE ADDRESS
  T. Nakayama, Division of Cardiovascular Surgery, Ehime Prefetural Central 
Hospital, Matsuyama, Japan.
FULL RECORD ENTRY DATE
  2011-03-09
SOURCE
  Kyobu geka. The Japanese journal of thoracic surgery (2010) 63:13 
(1113-1118). Date of Publication: Dec 2010
VOLUME
  63
ISSUE
  13
FIRST PAGE
  1113
LAST PAGE
  1118
DATE OF PUBLICATION
  Dec 2010
ISSN
  0021-5252
ABSTRACT
  Preferable surgical approaches to aortic diseases occurring between the 
aortic root and the arch in patients with functioning tracheotomy or 
permanent tracheostomy are described for securing adequate exposure and 
avoiding postoperative mediastinitis. Case 1: A 41-year-old man with Marfan 
syndrome presented with chronic type A thrombosed aortic dissection and 
severe aortic valve regurgitation. He had had a functional tracheostomy for 
managing respiratory function due to traumatic spinal cord damage. The heart 
and the ascending aorta were shifted to the right side of the chest and 
showed a significant counterclockwise rotation. Therefore, the reverse 
L-figure approach of a right-sided 3rd intercostal anterior thoracostomy and 
lower midline sternotomy was performed for Bentall operation. Case 2: A 
76-year-old woman presented with thoracic aortic aneurysm of 11 cm in 
diameter. She had had a permanent tracheostomy with total laryngectomy. 
Therefore, cram shell approach was performed for total arch replacement. The 
2 cases had no postoperative mediastinitis. These approaches are recommended 
for aortic diseases occurring in the ascending aorta or the aortic arch in 
patients with functioning tracheotomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aorta (surgery); thoracic aorta (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; aortic disease (surgery); article; cardiovascular surgery; case report; female; human; male; methodology; 
LANGUAGE OF ARTICLE
  Japanese
MEDLINE PMID
  21174658 (http://www.ncbi.nlm.nih.gov/pubmed/21174658)
PUI
  L360259725
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00215252&id=doi:&atitle=%5BPreferable+surgical+approaches+to+the+aortic+root-arch+in+patients+with+functioning+tracheostomy%5D.&stitle=Kyobu+Geka&title=Kyobu+geka.+The+Japanese+journal+of+thoracic+surgery&volume=63&issue=13&spage=1113&epage=1118&aulast=Nakayama&aufirst=Taisuke&auinit=T.&aufull=Nakayama+T.&coden=&isbn=&pages=1113-1118&date=2010&auinit1=T&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 696
TITLE
  Use of ECMO for resection of post-traumatic ruptured lung abscess with 
empyema
AUTHOR NAMES
  Brenner M.; O'Connor J.V.; Scalea T.M.
AUTHOR ADDRESSES
  (Brenner M., mbrenner@umm.edu; O'Connor J.V.; Scalea T.M.) University of 
Maryland, R. Adams Cowley Shock Trauma Center, University of Maryland School 
of Medicine, Baltimore, MD, United States.
CORRESPONDENCE ADDRESS
  M. Brenner, 22 S Greene St, Baltimore, MD 21201, United States. Email: 
mbrenner@umm.edu
AiP/IP ENTRY DATE
  2010-12-03
FULL RECORD ENTRY DATE
  2010-12-09
SOURCE
  Annals of Thoracic Surgery (2010) 90:6 (2039-2041). Date of Publication: 
December 2010
VOLUME
  90
ISSUE
  6
FIRST PAGE
  2039
LAST PAGE
  2041
DATE OF PUBLICATION
  December 2010
ISSN
  0003-4975
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  We report a patient who sustained multiple injuries from a motorcycle 
collision. He had a protracted intensive care course complicated by 
ventilator-associated pneumonia and empyema resulting from a ruptured lung 
abscess. He successfully underwent a thoracotomy, lung resection, 
decortication, and pleurectomy on veno-venous extracorporeal membrane 
oxygenation. © 2010 The Society of Thoracic Surgeons.
EMTREE DRUG INDEX TERMS
  antiinfective agent (drug therapy); nitric oxide; vasoactive agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  extracorporeal oxygenation; lung abscess (surgery); pleura empyema (surgery); 
EMTREE MEDICAL INDEX TERMS
  abnormal respiratory sound; adult; airway pressure; antimicrobial therapy; arterial gas; article; assisted ventilation; case report; crystalloid; decortication; disease severity; dyspnea; endotracheal intubation; endotracheal tube; flail chest; hematothorax; human; intensive care; Klebsiella pneumoniae infection (drug therapy); leukocytosis; lung infiltrate; lung resection; lung ventilation; male; multiple trauma; oxygen tension; physical examination; pleura; pleurectomy; pneumomediastinum; preoperative evaluation; priority journal; respiratory distress; respiratory failure; spinal cord decompression; spinal cord injury; spine fracture; spiral computer assisted tomography; thoracotomy; thorax drainage; thorax pain; thorax radiography; tracheostomy; traffic accident; transesophageal echocardiography; ventilator associated pneumonia (drug therapy); vertebra body; 
CAS REGISTRY NUMBERS
  nitric oxide (10102-43-9)
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010648796
MEDLINE PMID
  21095362 (http://www.ncbi.nlm.nih.gov/pubmed/21095362)
PUI
  L360036221
DOI
  10.1016/j.athoracsur.2010.01.085
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2010.01.085
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2Fj.athoracsur.2010.01.085&atitle=Use+of+ECMO+for+resection+of+post-traumatic+ruptured+lung+abscess+with+empyema&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=90&issue=6&spage=2039&epage=2041&aulast=Brenner&aufirst=Megan&auinit=M.&aufull=Brenner+M.&coden=ATHSA&isbn=&pages=2039-2041&date=2010&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 697
TITLE
  [Respiratory failure from upper airway collapse following anterior cervical 
spine surgery].
ORIGINAL (NON-ENGLISH) TITLE
  Insuficiencia respiratoria por obstrucción de la vía aérea superior en el 
postoperatorio de la cirugía de columna cervical por vía anterior.
AUTHOR NAMES
  Benatar-Haserfaty J.; Claros E.
AUTHOR ADDRESSES
  (Benatar-Haserfaty J.) Servicio de Anestesiología, Reanimación y Terapéutica 
del Dolor, Hospital Universitario Ramón y Cajal, Madrid.
(Claros E.)
CORRESPONDENCE ADDRESS
  J. Benatar-Haserfaty, Servicio de Anestesiología, Reanimación y Terapéutica 
del Dolor, Hospital Universitario Ramón y Cajal, Madrid. Email: 
jbenatar@telefonica.net
FULL RECORD ENTRY DATE
  2011-04-14
SOURCE
  Revista española de anestesiología y reanimación (2010) 57:9 (571-574). Date 
of Publication: Nov 2010
VOLUME
  57
ISSUE
  9
FIRST PAGE
  571
LAST PAGE
  574
DATE OF PUBLICATION
  Nov 2010
ISSN
  0034-9356
ABSTRACT
  OBJETIVES: To determine the frequencies of variables that might predispose 
to upper airway collapse in a series of patients undergoing anterior 
cervical spine surgery. Retrospective review of the medical records of 204 
patients who underwent anterior cervical spine neurosurgery between 2003 and 
2009. We gathered information on perioperative variables that might be 
related to upper airway collapse, on whether intensive care unit admission 
was planned or not, and on the moment when obstruction developed. Partial 
obstruction occurred in 7 cases (3.4%); 4 (1.9%) resolved with tracheal 
intubation and 3 (1.5%) required emergency tracheostomy. None of the 
variables were significantly associated with the development of 
postoperative upper airway obstruction in these patients. Upper airway 
obstruction after anterior cervical spine surgery is an unforeseen event and 
the emergency assessment of the airway may not coincide with the assessment 
of the anesthetist during the preanesthetic visit. This event may constitute 
an emergency for which preparation times and resources may differ from those 
available when this complication is foreseen. The problem for the 
anesthetist is not the impossibility of tracheal intubation but rather the 
difficulty of ventilating through a facial mask or supraglottic device, 
possibly with life-threatening consequences.
EMTREE DRUG INDEX TERMS
  corticosteroid (drug therapy); nonsteroid antiinflammatory agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (epidemiology, etiology, surgery, therapy); cervical spine (surgery); neurosurgery; postoperative complication (epidemiology, etiology); respiratory failure (epidemiology, etiology, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; disease predisposition; emergency; female; human; intensive care; male; methodology; middle aged; retrospective study; risk factor; tracheostomy; 
LANGUAGE OF ARTICLE
  Spanish
MEDLINE PMID
  21155338 (http://www.ncbi.nlm.nih.gov/pubmed/21155338)
PUI
  L360283837
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00349356&id=doi:&atitle=%5BRespiratory+failure+from+upper+airway+collapse+following+anterior+cervical+spine+surgery%5D.&stitle=Rev+Esp+Anestesiol+Reanim&title=Revista+espa%C3%B1ola+de+anestesiolog%C3%ADa+y+reanimaci%C3%B3n&volume=57&issue=9&spage=571&epage=574&aulast=Benatar-Haserfaty&aufirst=J.&auinit=J.&aufull=Benatar-Haserfaty+J.&coden=&isbn=&pages=571-574&date=2010&auinit1=J&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 698
TITLE
  Intensity modulated radiation therapy (IMRT) after supraglottic 
laryngectomy: Radiotherapy to the neck with sparing of the larynx and 
constrictors
AUTHOR NAMES
  Holland J.M.; Gagnon P.J.; Rhodes S.M.; Schindler J.S.
AUTHOR ADDRESSES
  (Holland J.M.; Gagnon P.J.; Rhodes S.M.; Schindler J.S.) Oregon Health and 
Science University, Portland, United States.
CORRESPONDENCE ADDRESS
  J.M. Holland, Oregon Health and Science University, Portland, United States.
FULL RECORD ENTRY DATE
  2010-10-19
SOURCE
  International Journal of Radiation Oncology Biology Physics (2010) 78:3 
SUPPL. 1 (S480-S481). Date of Publication: 1 Nov 2010
VOLUME
  78
ISSUE
  3
FIRST PAGE
  S480
LAST PAGE
  S481
DATE OF PUBLICATION
  1 Nov 2010
CONFERENCE NAME
  52nd Annual Meeting of the American Society for Radiation Oncology
CONFERENCE LOCATION
  San Diego, CA, United States
CONFERENCE DATE
  2010-10-31 to 2010-11-04
ISSN
  0360-3016
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Purpose/Objective(s): Radiotherapy after supraglottic laryngectomy is morbid 
with reported increased long-term swallowing difficulties, incidence of 
aspiration pneumonia and long-term tracheotomy dependence. Patients with 
high-risk nodal disease and negative laryngeal margins still require 
regional radiotherapy. We evaluated IMRT as a means of delivering 
radiotherapy to the neck while sparing the remaining larynx and structures 
involved in swallowing (base of tongue, pharyngeal constrictors). 
Materials/Methods: We utilized IMRT planning using Eclipse (Varian Medical 
Systems) software seeking to provide 95% coverage of our expanded (2 mm 
medially, 3 mm elsewhere) planning target volumes (PTVs) of a sample patient 
after supraglottic laryngectomy and bilateral neck dissection. We developed 
independent IMRT plans for three scenarios of postoperative regional 
radiotherapy: 1) High dose (63 Gy) to one side of the neck (levels 
retropharynx, Ib, II, III, IV, V) and no dose prescribed to the other side; 
2) High dose to one side of the neck (63 Gy) and low dose (56 Gy) to the 
other side (levels retropharynx, II, III, IV and V); and 3) High dose (63 
Gy) to both sides of the neck (levels retropharynx, Ib, II, III, IV and V). 
IMRT plans to both sides of the neck utilized 9 fields with carriage shifts 
for each field resulting in a total of 18 fields, while the ipsilateral neck 
only plan utilized 7 fields of which two contained carriage shifts. We 
sought to limit radiotherapy to the following organs at risk: pharyngeal 
constrictors, base of tongue, remaining larynx (true vocal cords, right 
arytenoid, left arytenoid, interarytenoid tissue), oral cavity, parotids, 
and spinal cord. Results: Using IMRT, adequate coverage of the PTVs was 
achieved while limiting dose to organs at risk. In scenario < 1, mean doses 
were 3124 cGy to the constrictors, 2576 cGy to the larynx and 3592 cGy to 
the base of tongue. In scenario < 2, mean doses were 4044 cGy to the 
constrictors, 2975 cGy to the larynx and 4272 cGy to the base of tongue. In 
scenario < 3 with high dose radiation to both sides of the neck, mean doses 
were 4414 cGy to the constrictors, 3718 cGy to the larynx and 5218 cGy to 
the base of tongue. Conclusions: IMRT can be used after supraglottic 
laryngectomy to treat high risk nodal disease while limiting potentially 
morbid radiotherapy to the remaining larynx, pharyngeal constrictors and 
base of tongue.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensity modulated radiation therapy; laryngectomy; larynx; neck; oncology; radiotherapy; society; 
EMTREE MEDICAL INDEX TERMS
  aspiration pneumonia; drug megadose; low drug dose; mouth cavity; neck dissection; patient; planning; radiation dose; risk; software; spinal cord; swallowing; tissues; tongue; tracheotomy; vocal cord; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70278101
DOI
  10.1016/j.ijrobp.2010.07.1127
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijrobp.2010.07.1127
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03603016&id=doi:10.1016%2Fj.ijrobp.2010.07.1127&atitle=Intensity+modulated+radiation+therapy+%28IMRT%29+after+supraglottic+laryngectomy%3A+Radiotherapy+to+the+neck+with+sparing+of+the+larynx+and+constrictors&stitle=Int.+J.+Radiat.+Oncol.+Biol.+Phys.&title=International+Journal+of+Radiation+Oncology+Biology+Physics&volume=78&issue=3&spage=S480&epage=S481&aulast=Holland&aufirst=J.M.&auinit=J.M.&aufull=Holland+J.M.&coden=&isbn=&pages=S480-S481&date=2010&auinit1=J&auinitm=M
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 699
TITLE
  International survey of physician recommendation for tracheostomy for 
children with Spinal Muscular Atrophy Type I
AUTHOR NAMES
  Benson R.C.; Hardy K.; Gildengorin G.; Hsia D.
AUTHOR ADDRESSES
  (Benson R.C.; Hardy K.; Gildengorin G.; Hsia D.) Children's Hospital, 
Research Center Oakland, Oakland, United States.
CORRESPONDENCE ADDRESS
  R.C. Benson, Children's Hospital, Research Center Oakland, Oakland, United 
States.
FULL RECORD ENTRY DATE
  2011-03-16
SOURCE
  Chest (2010) 138:4. Date of Publication: October 2010
VOLUME
  138
ISSUE
  4
DATE OF PUBLICATION
  October 2010
CONFERENCE NAME
  CHEST 2010 Annual Meeting
CONFERENCE LOCATION
  Vancouver, BC, Canada
CONFERENCE DATE
  2010-10-30 to 2010-11-04
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians
ABSTRACT
  PURPOSE: The ethics of invasive mechanical ventilation for children with the 
progressive neuromuscular disease Spinal Muscular Atrophy Type I (SMA I) is 
highly debated. We conducted this international survey to identify regional 
factors and physician characteristics associated with recommendation for 
tracheostomy and ventilation for SMA I. METHODS: A cross-sectional 
international online survey was distributed to 1736 pediatric pulmonologists 
and intensivists from online membership directories of ATS, ACCP, and ERS. 
Questions explored physician demographics, attitudes and experience with SMA 
and end-of-life care, knowledge of consensus guidelines, and recommendations 
for respiratory care of SMA I. Predictor variables were analyzed with 
Chi-square testing and entered into a logistic regression model. RESULTS: 
363 (21%) physicians completed the survey; 84% were pediatric pulmonologists 
and 16% pediatric intensivists. 70% of respondents were from the U.S. 
Physicians averaged 16 years of experience in their field of practice. 50% 
of physicians were aware of SMA consensus guidelines. 60% agreed invasive 
ventilation is acceptable for SMA I patients with chronic respiratory 
failure. In univariate analysis, physicians from Commonwealth countries 
(U.K., Canada, Australia, etc.) were significantly less likely to recommend 
tracheostomy/ventilation than U.S. physicians (7% vs. 25%, p = 0.011). 
Logistic regression modeling identified years of experience, agreement with 
a pro-life statement, and recommendation for noninvasive ventilation as 
predictive of recommendation for long-term invasive ventilation for SMA I. 
CONCLUSION: In the largest international survey on this topic, we identified 
regional differences in physician recommendation for tracheostomy/mechanical 
ventilation for SMA I. We found that only half of physicians caring for 
children with SMA I were aware of consensus guidelines. Logistic regression 
modeling identified physician experience and attitudes as predictive of 
recommendation of long-term invasive ventilation. CLINICAL IMPLICATIONS: Key 
goals for SMA I include improving awareness of treatment options, reducing 
variability of care, reducing costly invasive interventions, and minimizing 
suffering of patients and families. Our data demonstrate a need for 
increased awareness of consensus guidelines and will hopefully serve to 
stimulate physician dialogue to further these goals.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  child; physician; spinal muscular atrophy; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; artificial ventilation; Australia; Canada; chronic respiratory failure; consensus; directory; ethics; logistic regression analysis; model; neuromuscular disease; patient; predictor variable; respiratory care; terminal care; United States; univariate analysis; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70361424
DOI
  10.1378/chest.10738
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.10738
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.10738&atitle=International+survey+of+physician+recommendation+for+tracheostomy+for+children+with+Spinal+Muscular+Atrophy+Type+I&stitle=Chest&title=Chest&volume=138&issue=4&spage=&epage=&aulast=Benson&aufirst=Renee+C.&auinit=R.C.&aufull=Benson+R.C.&coden=&isbn=&pages=-&date=2010&auinit1=R&auinitm=C
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 700
TITLE
  Acute airway obstruction in cervical spinal procedures with bone 
morphogenetic proteins
AUTHOR NAMES
  Yaremchuk K.L.; Toma M.S.; Somers M.L.; Peterson E.
AUTHOR ADDRESSES
  (Yaremchuk K.L., Kyaremc1@hfhs.org; Somers M.L.) Department of 
Otolaryngology-Head and Neck Surgery, Wayne State University, Henry Ford 
Medical Group, 2799 West Grand Boulevard, Detroit, MI 48202, United States.
(Peterson E.) Department of Biostatistics and Research Epidemiology, Wayne 
State University, Detroit, MI, United States.
(Toma M.S.) Henry Ford Health System, Wayne State University, Detroit, MI, 
United States.
(Toma M.S.) School of Medicine, Wayne State University, Detroit, MI, United 
States.
CORRESPONDENCE ADDRESS
  K. L. Yaremchuk, Department of Otolaryngology-Head and Neck Surgery, Wayne 
State University, Henry Ford Medical Group, 2799 West Grand Boulevard, 
Detroit, MI 48202, United States. Email: Kyaremc1@hfhs.org
AiP/IP ENTRY DATE
  2010-12-15
FULL RECORD ENTRY DATE
  2010-12-22
SOURCE
  Laryngoscope (2010) 120:10 (1954-1957). Date of Publication: October 2010
VOLUME
  120
ISSUE
  10
FIRST PAGE
  1954
LAST PAGE
  1957
DATE OF PUBLICATION
  October 2010
ISSN
  0023-852X
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Objectives: Bone morphogenetic proteins (BMP) used in anterior cervical 
spinal procedures causes an inflammatory response resulting in upper-airway 
obstruction between postoperative days 2 to 7. The purpose of this study is 
to determine the incidence and severity of complications associated with use 
of BMP. Study Design: Retrospective cohort study. Methods: This is a 
retrospective study of 260 patients who underwent cervical spinal procedures 
with BMP from 2004 to 2009 and a control group of 515 patients who underwent 
cervical spinal procedures without BMP during the same period at a tertiary 
care institution. The two groups were compared on hospital length of stay 
(LOS), hospital charges, incidence of airway obstruction, unplanned 
intubations after surgery, tracheotomies, intensive care unit (ICU) 
admissions, hoarseness, dyspnea, respiratory failure, dysphasia, dysphagia, 
readmissions, and need for percutaneous endoscopic gastrostomy (PEG) tubes. 
Results: Patients who underwent cervical spine procedures with BMP were 
noted to have significantly longer hospital stays (P = .001) and higher 
hospital charges (P = .001) than the control group. Tracheotomies (P = 
.024), unplanned intubations after surgery (P = .003), dysphagia (P = .001), 
dyspnea (P = .001), respiratory failure (P = .001), hospital readmissions (P 
= .040), ICU admissions (P = .001), and 90-day mortality rates (P = .047) 
were increased for the BMP group. Conclusions: The use of BMP in anterior 
cervical spinal procedures results in acute airway obstruction due to an 
extensive soft-tissue inflammatory reaction that is most likely to occur 2 
to 7 days after surgery. The increased incidence of unplanned intubations 
and tracheotomies demonstrates the risk associated with BMP in cervical 
spinal procedures. © 2010 The American Laryngological, Rhinological and 
Otological Society, Inc.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  recombinant bone morphogenetic protein 2 (drug toxicity); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute airway obstruction (complication); airway obstruction (complication); anterior spine fusion; 
EMTREE MEDICAL INDEX TERMS
  article; cervical spine; controlled study; dysphagia (complication); dysphasia (complication); dyspnea (complication); hoarseness (complication); hospital charge; hospital readmission; hospitalization; human; intensive care unit; intubation; length of stay; major clinical study; percutaneous endoscopic gastrostomy; priority journal; respiratory failure (complication); retrospective study; tertiary health care; tracheotomy; 
DEVICE TRADE NAMES
  INFUSE  , United StatesMedtronic

DEVICE MANUFACTURERS
   (United States)Medtronic
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010667981
MEDLINE PMID
  20824786 (http://www.ncbi.nlm.nih.gov/pubmed/20824786)
PUI
  L360097411
DOI
  10.1002/lary.21096
FULL TEXT LINK
  http://dx.doi.org/10.1002/lary.21096
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0023852X&id=doi:10.1002%2Flary.21096&atitle=Acute+airway+obstruction+in+cervical+spinal+procedures+with+bone+morphogenetic+proteins&stitle=Laryngoscope&title=Laryngoscope&volume=120&issue=10&spage=1954&epage=1957&aulast=Yaremchuk&aufirst=Kathleen+L.&auinit=K.L.&aufull=Yaremchuk+K.L.&coden=LARYA&isbn=&pages=1954-1957&date=2010&auinit1=K&auinitm=L
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 701
TITLE
  Mechanical insufflation exsufflation: Practice patterns among respiratory 
therapists in ontario, canada
AUTHOR NAMES
  Prevost S.; Brooks D.; Bédard M.; Biman B.; Bwititi P.T.
AUTHOR ADDRESSES
  (Prevost S.) St Joseph's Hospital, Toronto, Canada.
(Brooks D.; Bédard M.) University of Toronto, Toronto, Canada.
(Bédard M.) Lakehead University, Thunder Bay, Canada.
(Biman B.) Thunder Bay Regional Health Sciences Centre, Thunder Bay, Canada.
(Bwititi P.T.) Charles Sturt University, Australia.
CORRESPONDENCE ADDRESS
  S. Prevost, St Joseph's Hospital, Toronto, Canada.
FULL RECORD ENTRY DATE
  2013-04-26
SOURCE
  Canadian Respiratory Journal (2010) 17 SUPPL. SB (12B). Date of Publication: 
September-October 2010
VOLUME
  17
FIRST PAGE
  12B
DATE OF PUBLICATION
  September-October 2010
CONFERENCE NAME
  2010 Canadian Respiratory Conference: A Breath of Fresh Air
CONFERENCE LOCATION
  Halifax, NS, Canada
CONFERENCE DATE
  2010-04-29 to 2010-05-01
ISSN
  1198-2241
BOOK PUBLISHER
  Pulsus Group Inc.
ABSTRACT
  Background: The mechanical insufflator exsufflator (MIE) is effective in 
assisting cough and in helping to avoid unplanned hospitalizations, 
tracheostomy and long-term ventilation in patients with neuromuscular 
disease or spinal cord injury. In spite of this, the availability and usage 
of the device in Canada is not known. Objective: To investigate practice 
patterns and availability of the MIE in Ontario hospitals. METHODS: A 
cross-sectional, self-administered mail survey was sent to a random sample 
of 400 respiratory therapists practicing within 96 Ontario hospitals. RESULT 
S: A total of 114 (28%) completed surveys were returned from 62 (65%) 
hospitals. Twenty hospitals (32%) had a MIE. Predominantly the respiratory 
therapist was the health care provider using the MIE. The device was most 
commonly used in the intensive care unit and medical/ surgical units in 
patients with neuromuscular diseases or spinal cord injuries. Optimal 
pressure spans of 35 cmH(2)O to 40 cmH(2)O were used by 54% of respondents. 
Fourteen of the 20 hospitals with a MIE had policies or guidelines in place 
and 4 of those hospitals had established staff competencies. Measurements of 
peak cough flow, maximal inspiratory/expiratory pressure and vital capacity 
were reported to be infrequently performed. CONCLUSIONS: This study 
demonstrated the MIE device is not widely available in Ontario hospitals and 
there are variations in how the devices are applied possibly resulting in 
suboptimal therapy. A comprehensive educational program on MIE devices that 
incorporates best practices and a practical component is recommended for 
current providers as well as for inclusion in student curriculum.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aeration; breathing; Canada; human; respiratory therapist; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; coughing; curriculum; devices; health care personnel; hospital; hospitalization; intensive care unit; neuromuscular disease; patient; policy; random sample; spinal cord injury; student; therapy; tracheostomy; vital capacity; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71040612
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11982241&id=doi:&atitle=Mechanical+insufflation+exsufflation%3A+Practice+patterns+among+respiratory+therapists+in+ontario%2C+canada&stitle=Can.+Respir.+J.&title=Canadian+Respiratory+Journal&volume=17&issue=&spage=12B&epage=&aulast=Prevost&aufirst=Shelley&auinit=S.&aufull=Prevost+S.&coden=&isbn=&pages=12B-&date=2010&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 702
TITLE
  Safety of percutaneous tracheostomy in trauma patients
AUTHOR NAMES
  Becker S.A.; Maldonado I.
AUTHOR ADDRESSES
  (Becker S.A.) Maimonides Medical Center, Brooklyn, United States.
(Becker S.A.; Maldonado I.) Jersey Shore University Medical Center, Trauma 
Center, Neptune, United States.
(Maldonado I.) Maimonides Medical Center, Surgical Critical Care, Brooklyn, 
United States.
CORRESPONDENCE ADDRESS
  S.A. Becker, Maimonides Medical Center, Brooklyn, United States.
FULL RECORD ENTRY DATE
  2010-11-02
SOURCE
  Intensive Care Medicine (2010) 36 SUPPL. 2 (S299). Date of Publication: 
September 2010
VOLUME
  36
FIRST PAGE
  S299
DATE OF PUBLICATION
  September 2010
CONFERENCE NAME
  23rd Annual Congress of the European Society of Intensive Care Medicine, 
ESICM
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2010-10-09 to 2010-10-13
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  INTRODUCTION. Percutaneous tracheostomy is a common procedure in many Trauma 
Intensive Care units. Concerns about the safety of percutaneous tracheostomy 
in patients without cervical spine clearance or with cervical spine injury 
limited its adoption for some surgeons. Most experts recommend the use of 
fiberoptic bronchoscopy during percutaneous tracheostomy. OBJECTIVES. To 
determine the safety of performing percutaneous tracheostomy in trauma 
patients with either no cervical spine clearance status or with cervical 
spine injury. METHODS.: From 1/1/2001 to 12/31/2007we retrospectively 
evaluated the medical records of all patients with blunt trauma who required 
tracheostomy in a Level II Trauma Center. Data was gathered from a trauma 
registry database and medical records. Patients were divided in two groups, 
Open Tracheostomy (OT) and Percutaneous Tracheostomy (PT). Patient age, 
Injury Severity Score (ISS), type of tracheostomy insertion method, cervical 
spine clearance status prior to tracheostomy, presence of cervical spine 
injury, use of bronchoscopy assistance in percutaneous tracheostomy, and 
immediate complications post tracheostomy were recorded for each patient. 
The results: The total number of tracheotomies during the study period was 
220 of which 125 (56%) were PT and 95(44%) were OT. Both groups were similar 
in age, sex and ISS distribution. Of theOTgroup, 60 (63%) were done in 
patients with no cervical spine clearance or cervical spine injury. No 
immediate complications were reported in the OTgroup. The PT group had 63 
cases (50.4%) done with no pre-operative cervical spine clearance or 
positive for cervical spine injury. The PT group underwent the procedure 
without bronchoscopy assistance in 95% of the cases. Two cases (1.5%) in the 
PT group were reported with postoperative bleeding from the insertion site 
that did not required intervention. Both cases were PT done without 
bronchoscopy assistance and did not have pre-operative cervical spine 
clearance. No other immediate complications were reported. RESULTS. The 
results of this study suggest that PT is safe in trauma patients without 
preoperative cervical spine clearance or with cervical injuries as compared 
with theOTgroup. Most of the PT cases were done without bronchoscopy 
assistance (95%). CONCLUSIONS. Percutaneous tracheostomy without 
bronchoscopic guidance is safe and efficacious in trauma patients even if 
cervical spine injury has not been excluded.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; intensive care; patient; safety; society; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  blunt trauma; bronchoscopy; cervical spine; cervical spine injury; data base; emergency health service; fiberoptic bronchoscopy; injury scale; intensive care unit; medical record; postoperative hemorrhage; register; surgeon; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70291072
DOI
  10.1007/s00134-010-2000-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-010-2000-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-010-2000-8&atitle=Safety+of+percutaneous+tracheostomy+in+trauma+patients&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=36&issue=&spage=S299&epage=&aulast=Becker&aufirst=S.A.&auinit=S.A.&aufull=Becker+S.A.&coden=&isbn=&pages=S299-&date=2010&auinit1=S&auinitm=A
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 703
TITLE
  Early tracheostomy advantages in neurointensive care, our 6 years 
experiences
AUTHOR NAMES
  Prochazka J.
AUTHOR ADDRESSES
  (Prochazka J.) Masaryk Hospital, Central ICU, Usti nad Labem, Czech 
Republic.
CORRESPONDENCE ADDRESS
  J. Prochazka, Masaryk Hospital, Central ICU, Usti nad Labem, Czech Republic.
FULL RECORD ENTRY DATE
  2010-11-02
SOURCE
  Intensive Care Medicine (2010) 36 SUPPL. 2 (S299). Date of Publication: 
September 2010
VOLUME
  36
FIRST PAGE
  S299
DATE OF PUBLICATION
  September 2010
CONFERENCE NAME
  23rd Annual Congress of the European Society of Intensive Care Medicine, 
ESICM
CONFERENCE LOCATION
  Barcelona, Spain
CONFERENCE DATE
  2010-10-09 to 2010-10-13
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  INTRODUCTION. Tracheostomy is among the most commonly performed surgical 
interventions in ICU in patients requiring ventilatory support. The best 
appropriate method of this procedure and the issue of timing of the 
tracheostomy are permanently debated. METHODS. Our ICU performed 351 
tracheostomies in total between January 2004 and December 2009; out of this 
number we assessed 293 tracheostomies in patients with neurological or 
neurosurgical diseases, 178 males and 115 females, aged 15 to 89, averege 
age 56.9 years. These interventions were performed using standard surgical 
approach with trachea fixation to the skin using suture. RESULTS. The most 
common diagnosis in our study were brain injuries (29%), followed by 
subarachnoidal hemorrhage (21%), hemorrhage stroke (18%), brain tumours 
(11%), ischemic stroke (10%), spinal injuries (6%) and other diagnoses in 5% 
patients. The average duration of the ventilatory support to tracheostomy 
was 4 days (rating from 1 to 20). The duration of the procedure averaged 
20.5 min (10-75 min). A surgical manipulation with tyreoid gland was 
necessary in 49% procedures. Majority of the tracheostomed patients were 
afterward transported into their regional hospitals (42%), 27% patients died 
in our ICU, 12% patients were transferred in other department within our 
hospital, 11% patients were decannulated in our hospital after stabilisation 
of their health condition,7%were transferred in nursing home or long-term 
medical care department and1%in spinal care department. The most common 
complication we met was bleeding (usually from tyroid gland's bed, in 4.8% 
procedures), discission of the tracheal ring during tracheal fixation to 
skin (3.4%) and endotracheal tube cuff perforation (2%). One patient 
suffered cardiac arrest with successful resuscitation during procedure. 
CONCLUSIONS. Performing an early tracheostomy (within 7 days of intubation) 
helps to decrease the level of sedation needed for tracheal tube tolerance, 
makes weaning from ventilatory support easier, improves pulmonary toilet, 
and in emergency transport conditions enables easier handling in contrast 
with intubated patients. Regarding neurointensive patients, at our 
department we definitely prefer early tracheostomy. Employing the surgical 
technique with tracheal fixation to the skin facilitates coping with 
possible periprocedural complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; society; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  bleeding; brain; brain injury; brain ischemia; cerebrovascular accident; coping behavior; cuff; diagnosis; emergency; endotracheal tube; female; health; heart arrest; hospital; intubation; male; medical care; nursing home; patient; perforation; resuscitation; sedation; skin; spine injury; subarachnoid hemorrhage; surgery; surgical approach; surgical technique; suture; trachea; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70291074
DOI
  10.1007/s00134-010-2000-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-010-2000-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-010-2000-8&atitle=Early+tracheostomy+advantages+in+neurointensive+care%2C+our+6+years+experiences&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=36&issue=&spage=S299&epage=&aulast=Prochazka&aufirst=J.&auinit=J.&aufull=Prochazka+J.&coden=&isbn=&pages=S299-&date=2010&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 704
TITLE
  Spinal cord infarction following cricotracheal resection
AUTHOR NAMES
  Windfuhr J.P.; Dülks A.
AUTHOR ADDRESSES
  (Windfuhr J.P., jwindfuhr@live.de) Department of Otorhinolaryngology, 
Malteser Krankenhaus St. Anna, Albertus Magnus Str. 33, Duisburg, Germany.
(Dülks A.) Department of Diagnostic and Interventional Radiology, Malteser 
Krankenhaus St. Anna, Duisburg, Germany.
CORRESPONDENCE ADDRESS
  J.P. Windfuhr, Department of Otorhinolaryngology, Malteser Krankenhaus St. 
Anna, Albertus Magnus Str. 33, Duisburg, Germany. Email: jwindfuhr@live.de
AiP/IP ENTRY DATE
  2010-07-07
FULL RECORD ENTRY DATE
  2010-09-01
SOURCE
  International Journal of Pediatric Otorhinolaryngology (2010) 74:9 
(1085-1088). Date of Publication: Septemper 2010
VOLUME
  74
ISSUE
  9
FIRST PAGE
  1085
LAST PAGE
  1088
DATE OF PUBLICATION
  Septemper 2010
ISSN
  0165-5876
BOOK PUBLISHER
  Elsevier Ireland Ltd, P.O. Box 85, Limerick, Ireland.
ABSTRACT
  We report a case of an 18-year-old female who was referred to our 
institution after incurring a permanent quadriplegia resulting from spinal 
cord infarction following cricotracheal resection. Methods were case report 
and review of the literature. A tracheal stenosis had resulted from 
long-term intubation after premature birth, followed by tracheotomy after 1 
year, surgical revision at 4 years of age and a spontaneous closure at the 
age of 6 after decannulation. At the age of 18, a cricotracheal resection 
was performed at another institution. At the termination of the procedure, a 
chin-to-chest suture was placed to prevent unintentional hyperextension of 
the neck. She was extubated on the third postoperative day, however, serious 
dyspnea required repeated re-intubation for 2 days thereafter. She developed 
paraplegia on the sixth postoperative day, prompting an MRI to be performed, 
which identified spinal cord edema. Intravenous administration of steroids 
in high doses was ineffective and unfortunately the patient has remained 
severely impaired since then. Permanent quadriplegia is a complication of 
cricotracheal resection with chin-to-chest sutures and should be included in 
the informed consent process. Therefore, a daily postoperative neurological 
examination should be performed in these patients. Immediate MRI should be 
performed if any abnormal findings are seen to verify the diagnosis. 
Quadriplegia in this setting likely resulted from compromised blood supply 
with concomitant edema, however, the exact cause of injury remains unclear: 
despite having chin-to-chest sutures, the patient's head remained in neutral 
position and was not in hyperflexion. Such an injury is likely more 
susceptible to steroid therapy if diagnosed as early as possible. © 2010 
Elsevier Ireland Ltd.
EMTREE DRUG INDEX TERMS
  steroid (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cricoid cartilage; spinal cord disease (drug therapy, complication, diagnosis, drug therapy); spinal cord infarction (drug therapy, complication, diagnosis, drug therapy); trachea resection; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; drug megadose; dyspnea; early diagnosis; endotracheal intubation; extubation; female; human; long term care; neurologic examination; nuclear magnetic resonance imaging; paraplegia; postoperative complication (complication); priority journal; quadriplegia; surgical technique; trachea stenosis (surgery); tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010438470
MEDLINE PMID
  20599281 (http://www.ncbi.nlm.nih.gov/pubmed/20599281)
PUI
  L50978519
DOI
  10.1016/j.ijporl.2010.05.036
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijporl.2010.05.036
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01655876&id=doi:10.1016%2Fj.ijporl.2010.05.036&atitle=Spinal+cord+infarction+following+cricotracheal+resection&stitle=Int.+J.+Pediatr.+Otorhinolaryngol.&title=International+Journal+of+Pediatric+Otorhinolaryngology&volume=74&issue=9&spage=1085&epage=1088&aulast=Windfuhr&aufirst=Jochen+P.&auinit=J.P.&aufull=Windfuhr+J.P.&coden=IPOTD&isbn=&pages=1085-1088&date=2010&auinit1=J&auinitm=P
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 705
TITLE
  Successful pregnancy and delivery in a C1 ASIA a spinal cord injured woman: 
The role of coordinated care between PM&R and obstetrics services: A case 
report
AUTHOR NAMES
  Lin C.Y.; McKenna S.; Shem K.L.
AUTHOR ADDRESSES
  (Lin C.Y.; McKenna S.; Shem K.L.) Stanford University Hospital, Stanford, 
United States.
CORRESPONDENCE ADDRESS
  C.Y. Lin, Stanford University Hospital, Stanford, United States.
FULL RECORD ENTRY DATE
  2011-07-28
SOURCE
  PM and R (2010) 2:9 SUPPL. 1 (S187-S188). Date of Publication: September 
2010
VOLUME
  2
ISSUE
  9
FIRST PAGE
  S187
LAST PAGE
  S188
DATE OF PUBLICATION
  September 2010
CONFERENCE NAME
  71st Annual Assembly of the American Academy of Physical Medicine and 
Rehabilitation
CONFERENCE LOCATION
  Seattle, WA, United States
CONFERENCE DATE
  2010-11-04 to 2010-11-07
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc.
ABSTRACT
  Patients or Programs: 20-year-old pregnant woman with a C1 ASIA A SCI. 
Program Description: 20-year-old woman involved in a motor vehicle accident 
who sustained a C1 ASIA A SCI, right BKA, and sacral and bilateral pubic 
rami fractures. Patient became pregnant through normal conception 2 years 
after the injury. The patient is ventilator dependent on room air with a 
tracheostomy, has nutritional support via PEG feeds, neurogenic bowel and 
bladder with suprapubic catheter. Patient was followed up closely throughout 
the pregnancy by coordinated care between the PM&R and High Risk Pregnancy 
Clinics. Pregnancy was complicated by gestational diabetes mellitus type A1. 
Setting: Tertiary care hospital. Results: At 33 weeks' routine follow-up, 
the patient was found to be in preterm labor with contractions every 1-2 
minutes. Patient was admitted to L&D Service. Rehabilitation service 
critical care staff was seconded to the L&D service. The patient was 
administered magnesium sulfate for tocolysis, however, this was discontinued 
when she developed mild hypoxia. The decision was made to proceed with labor 
augmentation with Pitocin when patient could not be weaned from oxygen 
supplementation. Patient received an epidural to decrease risk of autonomic 
dysreflexia. During her labor, patient had blood pressures to 140/100 and 
received IV hydralazine. The patient had a forceps-assisted delivery of a 
male infant in vertex presentation with Apgars of 6 at 1 minute and 8 at 5 
minutes, birth weight 1622 g. Discussion: This is the first case, to our 
knowledge, documenting successful normal spontaneous vaginal delivery to a 
woman with C1 ASIA A SCI. Common complications in pregnant women with SCI 
include changes in ventilator needs, autonomic dysreflexia, urinary tract 
infections, incontinence, pressure ulcers, thrombosis, spasticity, and 
preterm labor. Conclusions: Coordinated care between rehabilitation and 
obstetrics physicians, nursing, and respiratory care can minimize 
complications and ensure successful pregnancies and spontaneous vaginal 
deliveries in patients with high cervical complete SCI.
EMTREE DRUG INDEX TERMS
  hydralazine; magnesium sulfate; oxygen; oxytocin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; female; human; obstetrics; physical medicine; pregnancy; rehabilitation; spinal cord; 
EMTREE MEDICAL INDEX TERMS
  ambient air; autonomic dysreflexia; birth weight; bladder; blood pressure; boy; decubitus; epidural drug administration; follow up; forceps; fracture; high risk pregnancy; hospital; hypoxia; incontinence; injury; intensive care; male; neurogenic bowel; nursing; nutritional support; patient; physician; pregnancy diabetes mellitus; pregnant woman; premature labor; rehabilitation center; respiratory care; risk; spasticity; supplementation; suprapubic catheter; tertiary health care; thrombosis; tocolysis; tracheostomy; traffic accident; urinary tract infection; vaginal delivery; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70477768
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:&atitle=Successful+pregnancy+and+delivery+in+a+C1+ASIA+a+spinal+cord+injured+woman%3A+The+role+of+coordinated+care+between+PM%26R+and+obstetrics+services%3A+A+case+report&stitle=PM+R&title=PM+and+R&volume=2&issue=9&spage=S187&epage=S188&aulast=Lin&aufirst=Cindy+Y.&auinit=C.Y.&aufull=Lin+C.Y.&coden=&isbn=&pages=S187-S188&date=2010&auinit1=C&auinitm=Y
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 706
TITLE
  A particular evolution of Currarino syndrome
AUTHOR NAMES
  Simon L.G.; Constantinescu A.; Maftei A.G.; Popescu C.D.
AUTHOR ADDRESSES
  (Simon L.G.; Constantinescu A.; Maftei A.G.; Popescu C.D.) Neurology, 
Rehabilitation Hospital, Romania.
(Constantinescu A.; Popescu C.D.) Neurology, University of Medicine and 
Pharmacy, Gr.T.Popa Iasi, Iasi, Romania.
CORRESPONDENCE ADDRESS
  L.G. Simon, Neurology, Rehabilitation Hospital, Romania.
FULL RECORD ENTRY DATE
  2010-10-12
SOURCE
  European Journal of Neurology (2010) 17 SUPPL. 3 (319). Date of Publication: 
September 2010
VOLUME
  17
FIRST PAGE
  319
DATE OF PUBLICATION
  September 2010
CONFERENCE NAME
  14th Congress of the European Federation of Neurological Societies, EFNS
CONFERENCE LOCATION
  Geneva, Switzerland
CONFERENCE DATE
  2010-09-25 to 2010-09-28
ISSN
  1351-5101
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Introduction: Currarino syndrome (autosomal dominant genetic trait with a 
mutation in the HLXB9 homeobox gene) is a rare embryological complex of 
congenital caudal anomalies, including anorectal malformations, sacral bone 
defects and presacral tumoral mass (meningocele or teratoma). Objective:We 
present the case of Currarino syndrome with particular aspects in evolution. 
Case report: A caucasian female, 30 years old, presenting with sudden onset 
of intracranial hypertension, without any previous signs. Positive family 
history, but with incomplete investigations: one son with spina biphida, one 
sister with flaccid paraparesis postpartum, and a niece with congenital 
megacolon and anal stenosis. The neurological status at the admission in the 
Emergency Department was severe, with coma, seizures, respiratory failure 
requiring tracheostomy and mechanical ventilation, right peripheral facial 
paresis and flaccid paraplegia. The cerebral MRI excluded space occupying 
processes or vascular disease, but confirmed a diffuse cerebral oedema. The 
lumbosacral MRI confirmed the sacral splitting under S-2, an anterior sacral 
meningocele, a dermoid cyst and tethered spinal cord. The appearance of 
spontaneous meningocele fistula, complicated with meningomyelitis and 
meningoencephalitis explained the inaugural coma. The patient underwent 
surgical intervention consisting of aspiration and ligation of the anterior 
meningocele and tethered spinal cord releasing. Discussions:We report a good 
post-surgery evolution of the cerebral complication, but persistence of a 
transverse L-2 myelitis after 3 years. Conclusions: Tardive complications in 
a patient completely asymptomatic until the acute onset of the cerebral 
manifestations represent particular aspects in the evolution of a congential 
disease like the Currarino syndrome.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health care organization; 
EMTREE MEDICAL INDEX TERMS
  anorectal malformation; artificial ventilation; aspiration; autosomal dominant inheritance; bone defect; case report; Caucasian; coma; edema; emergency ward; facial nerve paralysis; family history; female; fistula; genetic trait; Hirschsprung disease; homeobox; intracranial hypertension; ligation; meningocele; meningoencephalitis; mutation; myelitis; nuclear magnetic resonance imaging; paraplegia; patient; respiratory failure; sacrum; seizure; stenosis; surgery; teratoma; tethered cord syndrome; tracheostomy; vascular disease; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70274532
DOI
  10.1111/j.1468-1331.2010.03232.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1468-1331.2010.03232.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13515101&id=doi:10.1111%2Fj.1468-1331.2010.03232.x&atitle=A+particular+evolution+of+Currarino+syndrome&stitle=Eur.+J.+Neurol.&title=European+Journal+of+Neurology&volume=17&issue=&spage=319&epage=&aulast=Simon&aufirst=L.G.&auinit=L.G.&aufull=Simon+L.G.&coden=&isbn=&pages=319-&date=2010&auinit1=L&auinitm=G
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 707
TITLE
  Reconstruction of a nasopharyngeal defect from cervical spine 
osteoradionecrosis
AUTHOR NAMES
  Kakarala K.; Richmon J.D.; Durand M.L.; Borges L.F.; Deschler D.G.
AUTHOR ADDRESSES
  (Kakarala K.; Deschler D.G., daniel_deschler@meei.harvard.edu) Department of 
Otolaryngology, Division of Head and Neck Surgery, Harvard Medical School, 
Boston, MA, United States.
(Durand M.L.) Department of Medicine, Division of Infectious Disease, 
Harvard Medical School, Boston, MA, United States.
(Borges L.F.) Neurosurgical Service, Massachusetts General Hospital, Harvard 
Medical School, Boston, MA, United States.
(Kakarala K.; Deschler D.G., daniel_deschler@meei.harvard.edu) Department of 
Otology and Laryngology, Harvard Medical School, Boston, MA, United States.
(Richmon J.D.) Department of Otolaryngology-Head and Neck Surgery, Division 
of Head and Neck Surgery, Johns Hopkins, Baltimore, MD, United States.
CORRESPONDENCE ADDRESS
  D. G. Deschler, Massachusetts Eye and Ear Infirmary, 243 Charles Street, 
Boston, MA 02114, United States. Email: daniel_deschler@meei.harvard.edu
AiP/IP ENTRY DATE
  2010-08-19
FULL RECORD ENTRY DATE
  2010-09-01
SOURCE
  Skull Base (2010) 20:4 (289-292). Date of Publication: 2010
VOLUME
  20
ISSUE
  4
FIRST PAGE
  289
LAST PAGE
  292
DATE OF PUBLICATION
  2010
ISSN
  1531-5010
  1532-0065 (electronic)
BOOK PUBLISHER
  Thieme Medical Publishers, Inc., 333 7th Avenue, New York, United States.
ABSTRACT
  Osteoradionecrosis of the cervical spine is a rare complication of radiation 
treatment of head and neck tumors that requires a multidisciplinary approach 
to management and reconstruction. The case of a 57-year-old man with 
osteoradionecrosis of the cervical spine secondary to radiation for 
metastatic hepatocellular carcinoma is presented. Operative debridement of 
the necrotic bone was performed and the nasopharyngeal soft tissue defect 
was reconstructed with a radial forearm free flap. The management and 
reconstruction options for osteoradionecrosis of the cervical spine are 
discussed. Copyright © 2010 by ThiemeMedical Publishers, Inc.
EMTREE DRUG INDEX TERMS
  amoxicillin plus clavulanic acid (drug therapy, oral drug administration); fluconazole (drug therapy, oral drug administration); sultamicillin (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone necrosis (drug therapy, complication, diagnosis, drug therapy, surgery); bone remodeling; cervical spine osteoradionecrosis (drug therapy, complication, diagnosis, 
drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; article; cancer radiotherapy; cancer surgery; case report; computer assisted tomography; debridement; free tissue graft; human; hyperbaric oxygen therapy; liver cell carcinoma (radiotherapy, surgery, therapy); male; nasopharynx; nuclear magnetic resonance imaging; oropharynx; pharynx disease (surgery); priority journal; radial forearm flap; soft tissue defect; tissue culture; tracheostomy; ulcer; 
CAS REGISTRY NUMBERS
  amoxicillin plus clavulanic acid (74469-00-4, 79198-29-1)
  fluconazole (86386-73-4)
  sultamicillin (76497-13-7)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010434826
PUI
  L359336124
DOI
  10.1055/s-0030-1249244
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0030-1249244
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15315010&id=doi:10.1055%2Fs-0030-1249244&atitle=Reconstruction+of+a+nasopharyngeal+defect+from+cervical+spine+osteoradionecrosis&stitle=Skull+Base&title=Skull+Base&volume=20&issue=4&spage=289&epage=292&aulast=Kakarala&aufirst=Kiran&auinit=K.&aufull=Kakarala+K.&coden=SBKAB&isbn=&pages=289-292&date=2010&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 708
TITLE
  Multidisciplinary approach to prevent spinal cord ischemia after thoracic 
endovascular aneurysm repair for distal descending aorta
AUTHOR NAMES
  Matsuda H.; Ogino H.; Fukuda T.; Iritani O.; Sato S.; Iba Y.; Tanaka H.; Sasaki H.; Minatoya K.; Kobayashi J.; Yagihara T.
AUTHOR ADDRESSES
  (Matsuda H., hitmat@hsp.ncvc.go.jp; Ogino H.; Iritani O.; Sato S.; Iba Y.; 
Tanaka H.; Sasaki H.; Minatoya K.; Kobayashi J.; Yagihara T.) Department of 
Cardiovascular Surgery, National Cardiovascular Center, 7-5-1 Fujishirodai, 
Suita, 565-8565, Osaka, Japan.
(Fukuda T.) Department of Radiology, National Cardiovascular Center, Osaka, 
Japan.
CORRESPONDENCE ADDRESS
  H. Matsuda, Department of Cardiovascular Surgery, National Cardiovascular 
Center, 7-5-1 Fujishirodai, Suita, 565-8565, Osaka, Japan. Email: 
hitmat@hsp.ncvc.go.jp
AiP/IP ENTRY DATE
  2010-08-25
FULL RECORD ENTRY DATE
  2010-09-01
SOURCE
  Annals of Thoracic Surgery (2010) 90:2 (561-565). Date of Publication: 
August 2010
VOLUME
  90
ISSUE
  2
FIRST PAGE
  561
LAST PAGE
  565
DATE OF PUBLICATION
  August 2010
ISSN
  0003-4975
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background: This article discusses the multidisciplinary approach to prevent 
spinal cord ischemia (SCI) with reference to the incidence of SCI after 
thoracic endovascular aneurysm repair (TEVAR) associated with closure of the 
intercostal-lumbar artery that supplies the Adamkiewicz artery (ICA-AKA). 
Methods: We reviewed 60 patients [49 men, 57 to 89 years old] who underwent 
TEVAR (TAG [W. L. Gore & Associates, Flagstaff, AZ] 42; the Matsui-Kitamura 
(Kanazawa, Japan) 10; Talent [Medtronic Inc, Santa Rosa, CA] 5; TAG and 
Talent 3) for part of or the entire distal descending aorta between T7 and 
L2. These patients had frequently undergone aortic surgeries: ascending 
aorta (4), aortic arch (25), descending aorta (4), thoracoabdominal aorta 
(3), and abdominal aorta (19). The multidisciplinary approach consists of 
identification of the ICA-AKA by magnetic resonance angiography or computed 
tomographic angiography to avoid unnecessary coverage of the ICA-AKA, in 
combination with monitoring of motor evoked potentials, augmentation of mean 
arterial pressure (> 80 mm Hg), and cerebrospinal fluid drainage. Results: 
Spinal cord ischemia occurred in 4 patients and patent ICA-AKAs were covered 
in 3 of them. The overall incidence of SCI was 6.7% and 9.4% in the group of 
32 patients whose patent ICA-AKAs were covered by TEVAR. After treatment for 
SCI, 3 patients regained full ambulatory ability. Significant risk factors 
were identified as the artificial graft at the proximal landing zone, the 
number of covered zones (>8), the length of aortic coverage (>250 or >300 
mm), and the length of the uncovered distal aorta (<60 mm). Conclusions: A 
multidisciplinary approach is essential to prevent SCI after TEVAR for the 
distal descending aorta. This approach includes the preservation of patent 
ICA-AKAs after their identification, early diagnosis of SCI during TEVAR by 
monitoring motor evoked potentials, and prophylaxis and treatment of SCI by 
increasing mean arterial pressure to at least 80 mm Hg and performing 
cerebrospinal fluid drainage. © 2010 The Society of Thoracic Surgeons.
EMTREE DRUG INDEX TERMS
  methylprednisolone (drug therapy); naloxone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm surgery; aortic aneurysm (surgery); descending aorta; spinal cord ischemia (drug therapy, complication, drug therapy, prevention); 
EMTREE MEDICAL INDEX TERMS
  abdominal aorta; abdominal aortic aneurysm; adult; aged; aortic arch; aortic arch surgery; aortic graft; aortic surgery; artery injury (complication); artery thrombosis (complication); article; ascending aorta; bleeding; cerebrospinal fluid drainage; computed tomographic angiography; drug withdrawal; female; gender; groups by age; human; iliac artery; internal iliac artery; lumbar artery; magnetic resonance angiography; major clinical study; male; mean arterial pressure; motor evoked potential; operation duration; patient mobility; peroperative complication (complication); pneumonia (complication); priority journal; prophylaxis; surgical patient; surgical risk; tracheostomy; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
  naloxone (357-08-4, 465-65-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010447752
MEDLINE PMID
  20667350 (http://www.ncbi.nlm.nih.gov/pubmed/20667350)
PUI
  L359362914
DOI
  10.1016/j.athoracsur.2010.04.067
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2010.04.067
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2Fj.athoracsur.2010.04.067&atitle=Multidisciplinary+approach+to+prevent+spinal+cord+ischemia+after+thoracic+endovascular+aneurysm+repair+for+distal+descending+aorta&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=90&issue=2&spage=561&epage=565&aulast=Matsuda&aufirst=Hitoshi&auinit=H.&aufull=Matsuda+H.&coden=ATHSA&isbn=&pages=561-565&date=2010&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 709
TITLE
  Endoscopic endonasal resection of the odontoid process-clinical outcomes
AUTHOR NAMES
  Tormenti M.J.; Madhok R.; Carrau R.; Snyderman C.H.; Kassam A.B.; Gardner P.A.
AUTHOR ADDRESSES
  (Tormenti M.J.; Madhok R.; Carrau R.; Snyderman C.H.; Kassam A.B.)
(Gardner P.A.) Pittsburgh, United States.
CORRESPONDENCE ADDRESS
  M.J. Tormenti,
FULL RECORD ENTRY DATE
  2010-12-22
SOURCE
  Journal of Neurosurgery (2010) 113:2 (A406-A407). Date of Publication: 
August 2010
VOLUME
  113
ISSUE
  2
FIRST PAGE
  A406
LAST PAGE
  A407
DATE OF PUBLICATION
  August 2010
CONFERENCE NAME
  78th Annual Meeting of the American Association of Neurological Surgeons, 
AANS 2010
CONFERENCE LOCATION
  Philadelphia, PA, United States
CONFERENCE DATE
  2010-05-01 to 2010-05-05
ISSN
  0022-3085
BOOK PUBLISHER
  American Association of Neurological Surgeons
ABSTRACT
  Introduction: The treatment of odontoid disease from a ventral approach has 
traditionally consisted of a transoral approach. More recently, an 
endoscopic endonasal approach has been used to access this region for 
decompression of the cervicomedullary junction. Methods: A retrospective 
review was conducted for all patients from 1997-2008 who underwent a 
completely endoscopic endonasal odontoidectomy for decompression of the 
cervicomedullary junction. Each patient's clinical outcome was assessed 
using the Neck Disability Index (NDI) and Nurick cervical myelopathy scale. 
Results: Twenty-four patients underwent a completely endoscopic endonasal 
resection of the odontoid. The most common pathology treated was rheumatoid 
pannus disease. The mean patient age was 63.4 years. No patient suffered 
worsening of their preoperative neurologic status, and all patients having 
either improvement or stabilization of their neurologic status. Twenty-one 
of the 24 patients had an additional posterior fusion. No patients required 
a tracheostomy related to the surgical procedure or suffered a surgical site 
infection. Nurick and NDI data were available for 12 patients who had a mean 
follow-up of 28.6 months (range 3-57). The mean Nurick score postoperatively 
was 0.9, and no patient received a score of 5. The mean NDI score was 9.1 
(range 0-32). Nine of 12 patients had an NDI score of less than 15. 
Conclusions: A completely endoscopic endonasal approach can be performed for 
odontoid disease with good outcomes and low morbidity. In objective 
follow-up evaluation, the majority of patients returned to an excellent 
quality of life with no or minimal disability.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  odontoid process; surgeon; surgery; 
EMTREE MEDICAL INDEX TERMS
  cervical myelopathy; decompression; disability; follow up; infection; morbidity; neck; pannus; pathology; patient; quality of life; surgical technique; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70314126
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223085&id=doi:&atitle=Endoscopic+endonasal+resection+of+the+odontoid+process-clinical+outcomes&stitle=J.+Neurosurg.&title=Journal+of+Neurosurgery&volume=113&issue=2&spage=A406&epage=A407&aulast=Tormenti&aufirst=Matthew+J.&auinit=M.J.&aufull=Tormenti+M.J.&coden=&isbn=&pages=A406-A407&date=2010&auinit1=M&auinitm=J
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 710
TITLE
  Oral dantrolene and severe respiratory failure in a patient with chronic 
spinal cord injury
AUTHOR NAMES
  Javed M.; Bogdanov A.
AUTHOR ADDRESSES
  (Javed M., dr.mariajaved@gmail.com; Bogdanov A.) Department of Anaesthetics 
and Intensive Care, Stoke Mandeville Hospital, Buckinghamshire Hospitals NHS 
Trust, Aylesbury, United Kingdom.
(Javed M., dr.mariajaved@gmail.com) Orthopaedics Department, Nuffield 
Orthopaedic Centre, Oxford, United Kingdom.
CORRESPONDENCE ADDRESS
  M. Javed, Orthopaedics Department, Nuffield Orthopaedic Centre, Oxford, 
United Kingdom. Email: dr.mariajaved@gmail.com
AiP/IP ENTRY DATE
  2010-07-21
FULL RECORD ENTRY DATE
  2010-07-30
SOURCE
  Anaesthesia (2010) 65:8 (855-856). Date of Publication: August 2010
VOLUME
  65
ISSUE
  8
FIRST PAGE
  855
LAST PAGE
  856
DATE OF PUBLICATION
  August 2010
ISSN
  0003-2409
  1365-2044 (electronic)
BOOK PUBLISHER
  Blackwell Publishing Ltd, 9600 Garsington Road, Oxford, United Kingdom.
ABSTRACT
  Oral dantrolene is used widely for the treatment of spasticity in patients 
with spinal cord injury. A 60-year-old patient in the rehabilitation phase 
following cervical spine injury presented with generalised weakness and 
deteriorating respiratory function, requiring intensive care admission, 
tracheal intubation and ventilation. He had bilateral basal lung collapse 
and a raised diaphragm and was on high-dose oral dantrolene. The cessation 
of dantrolene resulted in a dramatic recovery of respiratory function within 
two days. High-dose oral dantrolene can cause severe respiratory 
insufficiency and may present difficulties in the differential diagnosis of 
respiratory failure in patients with high cervical spinal cord injuries. © 
2010 The Association of Anaesthetists of Great Britain and Ireland.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  dantrolene (adverse drug reaction, drug dose, drug therapy, oral drug 
administration); 
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (rehabilitation, therapy); chronic disease; respiratory failure (side effect, complication, etiology, side effect); 
EMTREE MEDICAL INDEX TERMS
  adult; airway pressure; arterial gas; article; atelectasis (side effect); breathing rate; case report; computed tomographic angiography; computer assisted tomography; differential diagnosis; disease severity; drug dose increase; drug dose reduction; drug megadose; drug withdrawal; endotracheal intubation; evening dosage; facial expression; fatigue (side effect); hospital admission; human; hypercapnia; hypoxia; intensive care; intermittent positive pressure ventilation; intubation; leg spasm (drug therapy); leg spasm (drug therapy); male; muscle spasm (drug therapy); physiotherapy; positive end expiratory pressure; rehabilitation care; respiratory acidosis; respiratory function; single drug dose; thorax radiography; tracheostomy; weakness; 
CAS REGISTRY NUMBERS
  dantrolene (14663-23-1, 7261-97-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010382191
MEDLINE PMID
  20560919 (http://www.ncbi.nlm.nih.gov/pubmed/20560919)
PUI
  L359151964
DOI
  10.1111/j.1365-2044.2010.06409.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1365-2044.2010.06409.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032409&id=doi:10.1111%2Fj.1365-2044.2010.06409.x&atitle=Oral+dantrolene+and+severe+respiratory+failure+in+a+patient+with+chronic+spinal+cord+injury&stitle=Anaesthesia&title=Anaesthesia&volume=65&issue=8&spage=855&epage=856&aulast=Javed&aufirst=Maria&auinit=M.&aufull=Javed+M.&coden=ANASA&isbn=&pages=855-856&date=2010&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 711
TITLE
  Safety of percutaneous tracheostomy in trauma patients
AUTHOR NAMES
  Maldonado I.M.; Becker S.B.
AUTHOR ADDRESSES
  (Maldonado I.M.; Becker S.B.) Maimonides Medical Center, Brooklyn, United 
States.
CORRESPONDENCE ADDRESS
  I.M. Maldonado, Maimonides Medical Center, Brooklyn, United States.
FULL RECORD ENTRY DATE
  2010-09-07
SOURCE
  Critical Care (2010) 14 SUPPL. 1 (S78). Date of Publication: 2010
VOLUME
  14
FIRST PAGE
  S78
DATE OF PUBLICATION
  2010
CONFERENCE NAME
  30th International Symposium on Intensive Care and Emergency Medicine, 
ISICEM
CONFERENCE LOCATION
  Brussels, Belgium
CONFERENCE DATE
  2010-03-09 to 2010-03-12
ISSN
  1364-8535
BOOK PUBLISHER
  BioMed Central Ltd.
ABSTRACT
  Introduction: Percutaneous tracheostomy is a common procedure in many trauma 
ICUs. A concern about the safety of performing percutaneous tracheostomy in 
patients with no cervical spine clearance or cervical spine injury has 
limited its adoption for some surgeons. Most experts recommend the use of 
fiberoptic bronchoscopy during the insertion of percutaneous tracheostomy. 
Methods:: From January 2001 to December 2007 we retrospectively evaluated 
the medical records of all patients with blunt trauma who required 
tracheostomy in a level II trauma center. Data were gathered from a trauma 
registry database and medical records. Patients were divided in two groups, 
open tracheostomy (OT) and percutaneous tracheostomy (PT). Patient age, 
Injury Severity Score (ISS), type of tracheostomy insertion method, cervical 
spine clearance status prior to tracheostomy, presence of cervical spine 
injury, use of bronchoscopy assistance in percutaneous tracheostomy, and 
immediate complications post tracheostomy were recorded for each patient. 
Results: The total number of tracheotomies during the study period was 220, 
of which 125 (56%) were PT and 95(44%) were OT. Both groups were similar in 
age, sex and ISS distribution. Of the OT group, 60 (63%) were done in 
patients with no cervical spine clearance or cervical spine injury. There 
were no immediate complications reported in the OT group. The PT group had 
63 cases (50.4%) done with no preoperative cervical spine clearance or 
positive for cervical spine injury. The PT group underwent the procedure 
without bronchoscopy assistance in 95% of the cases. Two cases (1.5%) in the 
PT group were reported with postoperative bleeding from the tracheostomy 
site that did not required intervention. Both cases were PT done without 
bronchoscopy assistance and did not have preoperative cervical spine 
clearance. No other immediate complications were reported. Conclusions: The 
results of this study suggest that PT is safe in trauma patients without 
preoperative cervical spine clearance or with cervical injuries as compared 
with the OT group. Most of the PT cases were done without bronchoscopy 
assistance (95%). This finding suggests the need for further study to 
clarify the role of bronchoscopy assistance in PT.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency medicine; injury; intensive care; patient; safety; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  blunt trauma; bronchoscopy; cervical spine; cervical spine injury; data base; emergency health service; fiberoptic bronchoscopy; injury scale; medical record; postoperative hemorrhage; register; surgeon; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70255471
DOI
  10.1186/cc8457
FULL TEXT LINK
  http://dx.doi.org/10.1186/cc8457
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13648535&id=doi:10.1186%2Fcc8457&atitle=Safety+of+percutaneous+tracheostomy+in+trauma+patients&stitle=Crit.+Care&title=Critical+Care&volume=14&issue=&spage=S78&epage=&aulast=Maldonado&aufirst=I.M.&auinit=I.M.&aufull=Maldonado+I.M.&coden=&isbn=&pages=S78-&date=2010&auinit1=I&auinitm=M
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 712
TITLE
  Anaesthetic aspects of implanting diaphragmatic pacing in patients with 
spinal cord injury
AUTHOR NAMES
  Story D.A.; Mariampillai E.; Nikfarjam M.; Howard M.; Nunn A.; Onders R.
AUTHOR ADDRESSES
  (Story D.A., David.Story@austin.org.au; Mariampillai E.; Nikfarjam M.; 
Howard M.; Nunn A.; Onders R.) Department of Anaesthesia, Austin Health, 
Melbourne, VIC, Australia.
(Story D.A., David.Story@austin.org.au; Nikfarjam M.) Department of Surgery, 
University of Melbourne, Australia.
(Story D.A., David.Story@austin.org.au) Trials Group, Australian and New 
Zealand College of Anaesthetists, Australia.
(Howard M.) Victorian Respiratory Support Service, Australia.
(Howard M.) Institute for Breathing and Sleep, Australia.
(Nunn A.) Victorian Spinal Cord Service, Australia.
(Onders R.) Minimally Invasive Surgery, University Hospitals Case Medical 
Center, Case Western Reserve University School of Medicine, OH, United 
States.
CORRESPONDENCE ADDRESS
  D. A. Story, Department of Anaesthesia, Austin Hospital, Studley Rd, 
Heidelberg, VIC 3084, Australia. Email: David.Story@austin.org.au
AiP/IP ENTRY DATE
  2010-09-29
FULL RECORD ENTRY DATE
  2010-10-04
SOURCE
  Anaesthesia and Intensive Care (2010) 38:4 (740-743). Date of Publication: 
July 2010
VOLUME
  38
ISSUE
  4
FIRST PAGE
  740
LAST PAGE
  743
DATE OF PUBLICATION
  July 2010
ISSN
  0310-057X
  1448-0271 (electronic)
BOOK PUBLISHER
  Australian Society of Anaesthetists, P.O. Box 600, Edgecliff, Australia.
ABSTRACT
  Some patients with high cervical spinal cord injury are largely or 
completely dependent on mechanical ventilator support. Diaphragmatic phrenic 
nerve pacing is a new technique that offers some patients greater 
independence from mechanical ventilation. In selected patients, electrodes 
are placed on the abdominal side of the diaphragm via laparoscopy. An 
external pacing box provides the pacing stimulus. We report our experience 
with four patients with spinal cord injury in a pilot project, presenting 
for laparoscopic insertion of diaphragmatic phrenic nerve pacing leads 
inserted. The surgery took about two hours and diaphragmatic mapping 
precluded muscle relaxants. We used desflurane with remifentanil for 
maintenance. Apart from transferring the patients to and from their usual 
ventilators, other anaesthesia issues were difficult venous and arterial 
access for lines and long-term tracheostomies with no cuff or cuffs filled 
with water. While hypotension was a frequent problem, one patient also 
developed intraoperative hypertension secondary to autonomic dysreflexia. 
Preoperative testing predicted pacing outcome with three of the four 
patients having successful pacing with tidal volumes of up to 10 ml/kg at 
the end of surgery. This initial Australian experience may lead to greater 
use of the technique.
EMTREE DRUG INDEX TERMS
  desflurane; muscle relaxant agent; phentolamine (drug therapy); remifentanil; water; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragmatic phrenic nerve pacing; spinal cord injury (surgery); surgical technique; 
EMTREE MEDICAL INDEX TERMS
  adult; article; autonomic dysreflexia; case report; electrode; human; hypertension (complication, drug therapy); hypotension (complication); laparoscopy; male; preoperative evaluation; tidal volume; tracheostomy; vascular access; ventilator; 
CAS REGISTRY NUMBERS
  desflurane (57041-67-5)
  muscle relaxant agent (9008-44-0)
  phentolamine (50-60-2, 73-05-2)
  remifentanil (132539-07-2)
  water (7732-18-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010508777
MEDLINE PMID
  20715740 (http://www.ncbi.nlm.nih.gov/pubmed/20715740)
PUI
  L359568492
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0310057X&id=doi:&atitle=Anaesthetic+aspects+of+implanting+diaphragmatic+pacing+in+patients+with+spinal+cord+injury&stitle=Anaesth.+Intensive+Care&title=Anaesthesia+and+Intensive+Care&volume=38&issue=4&spage=740&epage=743&aulast=Story&aufirst=D.A.&auinit=D.A.&aufull=Story+D.A.&coden=AINCB&isbn=&pages=740-743&date=2010&auinit1=D&auinitm=A
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 713
TITLE
  Video-assisted anterior transcervical approach for the reduction of 
irreducible atlantoaxial dislocation
AUTHOR NAMES
  Liu T.; Li F.; Xiong W.; Du X.; Fang Z.; Shang H.; Chen A.
AUTHOR ADDRESSES
  (Liu T.; Li F., lifengtongji@yahoo.cn; Xiong W.; Du X.; Fang Z.; Shang H.; 
Chen A.) Department of Orthopaedics, Tongji Hospital, Huazhong University of 
Science and Technology, Jiefang Road 1095, Wuhan, Hubei, China.
CORRESPONDENCE ADDRESS
  F. Li, Department of Orthopaedics, Tongji Hospital, Huazhong University of 
Science and Technology, Jiefang Road 1095, Wuhan, Hubei, China. Email: 
lifengtongji@yahoo.cn
AiP/IP ENTRY DATE
  2010-04-28
FULL RECORD ENTRY DATE
  2010-08-17
SOURCE
  Spine (2010) 35:15 (1495-1501). Date of Publication: 1 Jul 2010
VOLUME
  35
ISSUE
  15
FIRST PAGE
  1495
LAST PAGE
  1501
DATE OF PUBLICATION
  1 Jul 2010
ISSN
  1528-1159 (electronic)
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Study Design. Technique note. Objective. To describe a modified minimally 
invasive approach for the treatment of irreducible atlantoaxial dislocation 
(IAAD). Summary of the Background Data. Currently, the most frequently used 
route for the treatment of symptomatic IAAD is transoral-transpharyngeal 
approach. Although it provides the most direct route to the atlantoaxial 
joint, potential problems may arise because of traverse oral cavity, such as 
the potential risks of infection, postoperative disturbances of breathing, 
and swallowing. The aim of this study was to describe a less-invasive 
approach for IAAD. Methods. Four consecutive patients with IAAD underwent 
the combined video-assisted atlantoaxial transcervical release (VAAT) 
procedure and posterior occipital-cervical fusion or C1-C2 screw fixation at 
Tongji Hospital. Clinical characteristics, images data, operative variables, 
and follow-up data were recorded. Results. Four cases presented with signs 
and symptoms of spinal cord dysfunction caused by IAAD underwent 1-stage 
anterior release, reduction, and posterior fixation. Three cases received 
C1-C2 screw fixation, and 1 case with occipitocervical fixation. 
Postoperative imaging studies showed that complete decompression was 
achieved in all the cases. No systemic infections, cerebrospinal fluid 
leaks, or adverse neurologic sequelae were found. None of the patients 
required prolonged intubation, tracheostomy, or enteral tube feeding. All 
patients started to oral intake after anesthesia. Neurologic status in 1 
case remained at baseline whereas it improved in the others. The mean 
follow-up period was 9 months (6∼12 months). All cases achieved solid 
fusion, without implants failure. Conclusion. Our initial experience showed 
that the VAAT procedure for IAAD is a safe supplement and alternative to 
conventional and transcervical procedures. © 2010, Lippincott Williams & 
Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial dislocation (surgery); irreducible atlantoaxial dislocation (surgery); spine surgery; video assisted atlantoaxial transcervical release; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; anesthetic recovery; article; atlantoaxial joint; case report; cerebrospinal fluid otorrhea; endoscopic surgery; enteric feeding; feeding tube; female; follow up; food intake; fracture fixation; fracture nonunion (surgery); human; intubation; invasive procedure; male; minimally invasive surgery; neck pain; neurological complication; odontoid process fracture (surgery); pedicle screw; posterior occipital cervical fusion; postoperative period; priority journal; shoulder pain; spinal cord decompression; spinal cord disease; spine fusion; spine radiography; surgical approach; tracheostomy; 
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010402065
MEDLINE PMID
  20395883 (http://www.ncbi.nlm.nih.gov/pubmed/20395883)
PUI
  L50884828
DOI
  10.1097/BRS.0b013e3181c4e048
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e3181c4e048
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15281159&id=doi:10.1097%2FBRS.0b013e3181c4e048&atitle=Video-assisted+anterior+transcervical+approach+for+the+reduction+of+irreducible+atlantoaxial+dislocation&stitle=Spine&title=Spine&volume=35&issue=15&spage=1495&epage=1501&aulast=Liu&aufirst=Tie&auinit=T.&aufull=Liu+T.&coden=SPIND&isbn=&pages=1495-1501&date=2010&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 714
TITLE
  Failed videolaryngoscope intubation in a patient with diffuse idiopathic 
skeletal hyperostosis and spinal cord injury
AUTHOR NAMES
  Thompson C.; Moga R.; Crosby E.T.
AUTHOR ADDRESSES
  (Thompson C., cthompson@ottawahospital.on.ca; Moga R.; Crosby E.T.) 
Department of Anesthesiology, Ottawa Hospital, University of Ottawa, 501 
Smyth Road, Ottawa, ON K1H 8L6, Canada.
CORRESPONDENCE ADDRESS
  C. Thompson, Department of Anesthesiology, Ottawa Hospital, University of 
Ottawa, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada. Email: 
cthompson@ottawahospital.on.ca
AiP/IP ENTRY DATE
  2010-05-03
FULL RECORD ENTRY DATE
  2010-07-22
SOURCE
  Canadian Journal of Anesthesia (2010) 57:7 (679-682). Date of Publication: 
July 2010
VOLUME
  57
ISSUE
  7
FIRST PAGE
  679
LAST PAGE
  682
DATE OF PUBLICATION
  July 2010
ISSN
  0832-610X
BOOK PUBLISHER
  Springer New York, 233 Springer Street, New York, United States.
ABSTRACT
  Purpose: A case of difficult intubation in a patient with cervical spinal 
cord injury with diffuse idiopathic skeletal hyperostosis (DISH) is 
described. The trachea could not be intubated with a videolaryngoscope, and 
successful intubation was achieved with a laryngeal mask airway device 
(LMAD) and a fibreoptic bronchoscope (FOB). Clinical features: A 65-yr-old 
male developed sudden tetraplegia after a fall. Initial attempts at securing 
his airway were unsuccessful with a videolaryngoscope, but success was 
achieved with a LMAD and a FOB. Diagnostic imaging revealed no cervical 
spine fracture but demonstrated severe airway distortion from DISH and a 
spinal cord contusion accounting for his tetraplegia. Subcutaneous neck 
emphysema likely secondary to difficult intubation was also identified, but 
it did not result in additional morbidity. Conclusions: Although often 
considered to be a benign entity, DISH can predispose patients to 
catastrophic cervical injury and difficult airway management. Careful review 
of plain radiographs in the spinal cord injury patient may assist with 
appropriate selection of airway interventions. The videolaryngoscope is 
useful for difficult airways, but its effectiveness may be compromised with 
an anteriorly displaced airway in combination with restricted cervical 
movement and limited oropharyngeal airspace. © 2010 Canadian 
Anesthesiologists' Society.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hyperostosis; laryngoscope; spinal cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; airway obstruction; article; artificial ventilation; bronchoscope; case report; diagnostic imaging; digestive tract intubation; emphysema; endotracheal intubation; falling; fiberoscope; Glasgow coma scale; human; laminoplasty; laryngeal mask; male; nuclear magnetic resonance imaging; priority journal; quadriplegia; spinal cord decompression; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  2010322631
MEDLINE PMID
  20428989 (http://www.ncbi.nlm.nih.gov/pubmed/20428989)
PUI
  L50892235
DOI
  10.1007/s12630-010-9313-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12630-010-9313-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0832610X&id=doi:10.1007%2Fs12630-010-9313-5&atitle=Failed+videolaryngoscope+intubation+in+a+patient+with+diffuse+idiopathic+skeletal+hyperostosis+and+spinal+cord+injury&stitle=Can.+J.+Anesth.&title=Canadian+Journal+of+Anesthesia&volume=57&issue=7&spage=679&epage=682&aulast=Thompson&aufirst=Calvin&auinit=C.&aufull=Thompson+C.&coden=CJOAE&isbn=&pages=679-682&date=2010&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 715
TITLE
  Unusually difficult nasogastric tube insertion
AUTHOR NAMES
  Gupta B.; Soni K.D.; D'Souza N.; Das S.
AUTHOR ADDRESSES
  (Gupta B.; Soni K.D.; D'Souza N.; Das S.) Department of Anesthesia, All 
India Institute of Medical Sciences JPNA Trauma Center, New Delhi, India.
CORRESPONDENCE ADDRESS
  B. Gupta, Department of Anesthesia All India Institute of Medical Sciences 
JPNA Trauma Center, New Delhi, India, India.
AiP/IP ENTRY DATE
  2010-05-20
FULL RECORD ENTRY DATE
  2010-07-15
SOURCE
  Journal of Neurosurgical Anesthesiology (2010) 22:3 (267-268). Date of 
Publication: July 2010
VOLUME
  22
ISSUE
  3
FIRST PAGE
  267
LAST PAGE
  268
DATE OF PUBLICATION
  July 2010
ISSN
  0898-4921
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture (surgery); endotracheal intubation; nasogastric tube; spinal cord compression (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; airway obstruction; bone graft; bone plate; case report; dysphagia; esophagus perforation; human; infection; laryngoscopy; letter; male; priority journal; quadriplegia; repeat procedure; spine surgery; trachea obstruction (complication, diagnosis, surgery); tracheostomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2010359831
MEDLINE PMID
  20479671 (http://www.ncbi.nlm.nih.gov/pubmed/20479671)
PUI
  L50915783
DOI
  10.1097/ANA.0b013e3181d65d36
FULL TEXT LINK
  http://dx.doi.org/10.1097/ANA.0b013e3181d65d36
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08984921&id=doi:10.1097%2FANA.0b013e3181d65d36&atitle=Unusually+difficult+nasogastric+tube+insertion&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=22&issue=3&spage=267&epage=268&aulast=Gupta&aufirst=Babita&auinit=B.&aufull=Gupta+B.&coden=JNANE&isbn=&pages=267-268&date=2010&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 716
TITLE
  An autopsied case of Parkinson's disease with severe hallucination and 
delusion
AUTHOR NAMES
  Noritaka Y.; Hisayoshi N.; Nozomi H.; Tomonobu N.; Satoko S.; Kazuhiro H.; Nobuyuki M.; Mayuki K.; Makoto I.; Maya M.; Mari Y.; Yoshio H.
AUTHOR ADDRESSES
  (Noritaka Y.; Hisayoshi N.; Nozomi H.; Tomonobu N.; Satoko S.; Kazuhiro H.; 
Nobuyuki M.) Dept. of Neurology, KARIYA TOYOTA General Hospital, Japan.
(Mayuki K.; Makoto I.) Dept. of Pathology, KARIYA TOYOTA General Hospital, 
Japan.
(Maya M.; Mari Y.; Yoshio H.) Institute for Medical Science of Aging, Aichi 
Medical Univ., Japan.
CORRESPONDENCE ADDRESS
  Y. Noritaka, Dept. of Neurology, KARIYA TOYOTA General Hospital, Japan.
FULL RECORD ENTRY DATE
  2011-06-27
SOURCE
  Neuropathology (2010) 30:3 (345). Date of Publication: June 2010
VOLUME
  30
ISSUE
  3
FIRST PAGE
  345
DATE OF PUBLICATION
  June 2010
CONFERENCE NAME
  51st Annual Meeting of the Japanese Society of Neuropathology
CONFERENCE LOCATION
  Tokyo, Japan
CONFERENCE DATE
  2010-04-23 to 2010-04-25
ISSN
  0919-6544
BOOK PUBLISHER
  Blackwell Publishing
ABSTRACT
  44 years-old man was aware of uselessness of left hand and gait disturbance. 
He had cogwheel rigidity and postural instability. Antiparkinsonian drugs 
worked well, so he was diagnosed as Parkinson disease. 10 years later, 
severe hallucination and delusion appeared. Because of deterioration of his 
ADL, it was unavoidable to perform gastrostomy and tracheotomy. Paralytic 
ileus occurred repeatedly. After end, he showed emaciation, and died of 
severe infection at age of 60.The brain weight was 1160g. Mild atrophy of 
frontal lobe was noticed. Microscopically, neuronal loss with astrogliosis 
was present in the substantia nigra, locus ceruleus and dorsal motor nucleus 
of the vagus, and in which numerous Lewy bodies were detected. But Lewy 
bodies were sparse in the limbic system and other cerebral cortex. Mild NFT, 
coiled body and argyrophilic threads in the cerebrum, and vacuolar 
myelopathy were found. From the appearance of Lewy bodies and α-synuclein 
positive structures, we regarded this case as brain stem type (Mackeith) and 
stage 4 (Braak). Severe hallucination and delusion weren't linked to the 
distribution of Lewy bodies in the cerebrum.
EMTREE DRUG INDEX TERMS
  antiparkinson agent; synuclein; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  delusion; hallucination; Japanese (people); neuropathology; Parkinson disease; society; 
EMTREE MEDICAL INDEX TERMS
  astrocytosis; atrophy; body weight loss; brain; brain cortex; brain stem; brain weight; coiled body; deterioration; frontal lobe; gait; gastrostomy; hand; infection; Lewy body; limbic system; locus ceruleus; male; motoneuron nucleus; paralytic ileus; rigidity; spinal cord disease; substantia nigra; tracheotomy; vagus nerve; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70443506
DOI
  10.1111/j.1440-1789.2010.01036.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1440-1789.2010.01036.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:10.1111%2Fj.1440-1789.2010.01036.x&atitle=An+autopsied+case+of+Parkinson%27s+disease+with+severe+hallucination+and+delusion&stitle=Neuropathology&title=Neuropathology&volume=30&issue=3&spage=345&epage=&aulast=Noritaka&aufirst=Y.&auinit=Y.&aufull=Noritaka+Y.&coden=&isbn=&pages=345-&date=2010&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 717
TITLE
  Acute management of traumatic spinal cord injury in a Greek and a Swedish 
region: A prospective, population-based study
AUTHOR NAMES
  Divanoglou A.; Seiger Å.; Levi R.
AUTHOR ADDRESSES
  (Divanoglou A., anestis.divanoglou@ki.se; Seiger Å.; Levi R.) Division of 
Neuro-rehabilitation, Department of Neurobiology, Care Sciences and Society, 
Karolinska Institutet, Stockholm, Sweden.
(Levi R.) Division of Rehabilitation Medicine, Umea University, Umea, 
Sweden.
CORRESPONDENCE ADDRESS
  A. Divanoglou, Division of Neuro-rehabilitation, Karolinska Institutet, 
Frösundaviks allé 13, 16989, Stockholm, Sweden. Email: 
anestis.divanoglou@ki.se
AiP/IP ENTRY DATE
  2009-12-24
FULL RECORD ENTRY DATE
  2010-06-23
SOURCE
  Spinal Cord (2010) 48:6 (477-482). Date of Publication: June 2010
VOLUME
  48
ISSUE
  6
FIRST PAGE
  477
LAST PAGE
  482
DATE OF PUBLICATION
  June 2010
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design:Prospective, population-based study. This paper is part of the 
Stockholm Thessaloniki Acute Traumatic Spinal Cord Injury Study 
(STATSCIS).Objectives:To characterize patient populations and to compare 
acute management after traumatic spinal cord injury (TSCI).Settings:The 
Greater Thessaloniki region in Greece and the Greater Stockholm region in 
Sweden.Methods:Inception cohorts with acute TSCI that were hospitalized 
during the study period, that is September 2006 to October 2007, were 
identified. Overall, 81 out of 87 cases consented to inclusion in 
Thessaloniki and 47 out of 49 in Stockholm. Data from Thessaloniki were 
collected through physical examinations, medical record reviews and 
communication with TSCI cases and medical teams. Data from Stockholm were 
retrieved from the Nordic Spinal Cord Injury Registry.Results:There were no 
significant differences between study groups with regard to core clinical 
characteristics. In contrast, there were significant differences in (1) 
transfer logistics from the scene of trauma to a tertiary-level hospital 
(number of intermediate admissions, modes of transportation and duration of 
transfer) and (2) acute key therapeutic interventions, that is, the use of 
mechanical ventilation (49% in Thessaloniki versus 20% in Stockholm), and 
performance of tracheostomy (36% in Thessaloniki versus 15% in Stockholm); 
spinal surgery was performed significantly more often and earlier in 
Stockholm than in Thessaloniki.Conclusions:Despite largely similar core 
clinical characteristics, Stockholm and Thessaloniki cases underwent 
significantly different acute management, most probably to be attributed to 
adaptations to the differing regional approaches of care one following a 
systematic approach of SCI care and the other not. © 2010 International 
Spinal Cord Society All rights reserved.
EMTREE DRUG INDEX TERMS
  anticoagulant agent (drug therapy); corticosteroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (drug therapy, drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; clinical trial; controlled clinical trial; controlled study; Greece; hospital admission; human; major clinical study; patient transport; priority journal; spinal cord lesion; spine surgery; Sweden; tertiary health care; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010318991
MEDLINE PMID
  20029396 (http://www.ncbi.nlm.nih.gov/pubmed/20029396)
PUI
  L50743714
DOI
  10.1038/sc.2009.160
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2009.160
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2009.160&atitle=Acute+management+of+traumatic+spinal+cord+injury+in+a+Greek+and+a+Swedish+region%3A+A+prospective%2C+population-based+study&stitle=Spinal+Cord&title=Spinal+Cord&volume=48&issue=6&spage=477&epage=482&aulast=Divanoglou&aufirst=A.&auinit=A.&aufull=Divanoglou+A.&coden=SPCOF&isbn=&pages=477-482&date=2010&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 718
TITLE
  Medical conditions and outcomes at 1 year after acute traumatic spinal cord 
injury in a Greek and a Swedish region: A prospective, population-based 
study
AUTHOR NAMES
  Divanoglou A.; Westgren N.; Bjelak S.; Levi R.
AUTHOR ADDRESSES
  (Divanoglou A., anestis.divanoglou@ki.se; Westgren N.; Levi R.) Division of 
Neuro-rehabilitation, Department of Neurobiology, Care Sciences and Society, 
Karolinska Institutet, Stockholm, Sweden.
(Westgren N.) Spinalis Spinal Cord Injury Rehabilitation Unit, Karolinska 
University Hospital, Stockholm, Sweden.
(Bjelak S.; Levi R.) Rehab Station Stockholm, Stockholm, Sweden.
(Levi R.) Division of Rehabilitation Medicine, Umea University, Umea, 
Sweden.
CORRESPONDENCE ADDRESS
  A. Divanoglou, Division of Neuro-rehabilitation, NVS, Karolinska Institutet, 
Frösundaviks allé 13, Stockholm 16989, Sweden. Email: 
anestis.divanoglou@ki.se
AiP/IP ENTRY DATE
  2009-12-24
FULL RECORD ENTRY DATE
  2010-06-23
SOURCE
  Spinal Cord (2010) 48:6 (470-476). Date of Publication: June 2010
VOLUME
  48
ISSUE
  6
FIRST PAGE
  470
LAST PAGE
  476
DATE OF PUBLICATION
  June 2010
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design:Prospective, population-based study. This paper is part of the 
Stockholm Thessaloniki Acute Traumatic Spinal Cord Injury Study (STATSCIS). 
Objectives:To evaluate and compare outcomes, length of stay (LOS), 
associated conditions and medical complications at 1-year post-trauma. 
Settings:The Greater Thessaloniki region, Greece, and the Greater Stockholm 
region, Sweden. While Stockholm follows a SCI system of care, Thessaloniki 
follows a fragmented non-system approach. Subjects:Out of the 87 cases in 
Thessaloniki and the 49 cases in Stockholm who comprised the study 
population of STATSCIS, 75 and 42 cases respectively were successfully 
followed-up during the first year post-trauma. Results:Significantly 
superior outcomes (that is, survival with neurological recovery, functional 
ability and discharge to home) and shorter LOS for initially motor complete 
cases occurred in Stockholm. Management routines known to increase long-term 
morbidity, for example, long-term tracheostomy and indwelling urethral 
catheters were significantly more common in Thessaloniki. Major medical 
complications, that is, multiple pressure ulcers, heterotopic ossification 
and bacteremia/sepsis were more frequent in Thessaloniki. Conclusions:Our 
findings show how two rather similar cohorts of TSCI manifest large 
discrepancies in terms of 1-year outcomes and complications, depending on 
the type of management they receive. As the major difference between regions 
was the presence or absence of a SCI system of care, rather than differences 
in availability of modern medicine, the mere presence of the latter does not 
seem to be sufficient to guarantee adequate outcomes. This study provides 
strong evidence as to the urgent need of implementing a SCI system of care 
in Greece. © 2010 International Spinal Cord Society All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  outcome assessment; population research; spinal cord injury (disease management); 
EMTREE MEDICAL INDEX TERMS
  article; bacteremia (complication); bladder emptying; controlled study; decubitus (complication); follow up; functional status; Greece; health care delivery; heterotopic ossification (complication); hospital discharge; human; length of stay; major clinical study; morbidity; practice guideline; priority journal; respiratory tract infection (complication); sepsis (complication); survival; Sweden; tracheostomy; urinary tract infection (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010318985
MEDLINE PMID
  20029392 (http://www.ncbi.nlm.nih.gov/pubmed/20029392)
PUI
  L50743718
DOI
  10.1038/sc.2009.147
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2009.147
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2009.147&atitle=Medical+conditions+and+outcomes+at+1+year+after+acute+traumatic+spinal+cord+injury+in+a+Greek+and+a+Swedish+region%3A+A+prospective%2C+population-based+study&stitle=Spinal+Cord&title=Spinal+Cord&volume=48&issue=6&spage=470&epage=476&aulast=Divanoglou&aufirst=A.&auinit=A.&aufull=Divanoglou+A.&coden=SPCOF&isbn=&pages=470-476&date=2010&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 719
TITLE
  Anterior Spinal Cord Syndrome After Initiation of Treatment with Atenolol
AUTHOR NAMES
  Schneider G.S.
AUTHOR ADDRESSES
  (Schneider G.S.) Department of Emergency Medicine, Albert Einstein Medical 
Center, Philadelphia, PA, United States.
CORRESPONDENCE ADDRESS
  G.S. Schneider, Department of Emergency Medicine, Albert Einstein Medical 
Center, Philadelphia, PA, United States.
AiP/IP ENTRY DATE
  2010-05-28
FULL RECORD ENTRY DATE
  2010-06-15
SOURCE
  Journal of Emergency Medicine (2010) 38:5 (e49-e52). Date of Publication: 
June 2010
VOLUME
  38
ISSUE
  5
DATE OF PUBLICATION
  June 2010
ISSN
  0736-4679
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Anterior spinal cord syndrome is a rare condition with a variety of 
precipitating factors. Patients typically complain of weakness or paralysis 
of the extremities, often accompanied by pain, but frequently without a 
history of trauma. A 48-year-old man presented to the emergency department 
complaining of neck pain and inability to move his legs in the absence of 
trauma. Several hours prior he had seen his private physician and was given 
a dose of atenolol for elevated blood pressure. He had not previously been 
on medications for hypertension. His neurological examination revealed 
bilateral paralysis of the lower extremities. In the upper extremities he 
had weakness and sensory loss at the level of C6. Rectal tone was decreased 
and without sensation. Cervical and thoracic spine magnetic resonance 
imaging showed spondylotic disc disease, with disc herniation at C6-7 
causing severe spinal canal stenosis. Despite i.v. methylprednisolone, 
pressors, and a prolonged intensive care unit course, the patient was 
discharged 5 weeks later with continued neurological deficits. Anterior 
spinal cord syndrome results from compression of the anterior spinal artery 
and often occurs in the absence of traumatic injury. The recognition, 
management, and prognosis of this condition are discussed. © 2010 Elsevier 
Inc. All rights reserved.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  atenolol (adverse drug reaction, drug therapy); 
EMTREE DRUG INDEX TERMS
  beta adrenergic receptor blocking agent (adverse drug reaction); ibuprofen (drug therapy); illicit drug; infusion fluid; methylprednisolone; phenylephrine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord disease (side effect, diagnosis, side effect); 
EMTREE MEDICAL INDEX TERMS
  abdominal pain; adult; airway; article; case report; cigarette smoking; deep vein thrombosis (complication); dyspnea; emergency care; gastritis; gastrointestinal hemorrhage (complication); hand paresthesia; headache; hospitalization; human; hypertension (drug therapy); hypotension (side effect); intensive care; intervertebral disk hernia; leg injury; length of stay; lethargy; male; muscle reflex; muscle tone; neck pain; neurologic examination; nuclear magnetic resonance imaging; paralysis (diagnosis); primary medical care; priority journal; rehabilitation care; spinal cord compression; spondylosis (diagnosis); stenosis; stress; thorax pain; tracheostomy; treatment duration; urine incontinence; ventilator associated pneumonia (complication); 
CAS REGISTRY NUMBERS
  atenolol (29122-68-7)
  ibuprofen (15687-27-1, 79261-49-7)
  methylprednisolone (6923-42-8, 83-43-2)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
EMBASE CLASSIFICATIONS
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010287713
MEDLINE PMID
  18597977 (http://www.ncbi.nlm.nih.gov/pubmed/18597977)
PUI
  L50194171
DOI
  10.1016/j.jemermed.2007.08.061
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jemermed.2007.08.061
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07364679&id=doi:10.1016%2Fj.jemermed.2007.08.061&atitle=Anterior+Spinal+Cord+Syndrome+After+Initiation+of+Treatment+with+Atenolol&stitle=J.+Emerg.+Med.&title=Journal+of+Emergency+Medicine&volume=38&issue=5&spage=&epage=&aulast=Schneider&aufirst=Gregory+S.&auinit=G.S.&aufull=Schneider+G.S.&coden=JEMMD&isbn=&pages=-&date=2010&auinit1=G&auinitm=S
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 720
TITLE
  Bilateral diaphragmatic paralysis: A sinister cause of respiratory failure
AUTHOR NAMES
  Smith T.; Hercules A.; Rana S.; Lega M.
AUTHOR ADDRESSES
  (Smith T.; Hercules A.; Rana S.; Lega M.) Allegheny General Hospital, 
Pittsburgh, United States.
CORRESPONDENCE ADDRESS
  T. Smith, Allegheny General Hospital, Pittsburgh, United States.
FULL RECORD ENTRY DATE
  2010-12-28
SOURCE
  Journal of General Internal Medicine (2010) 25 SUPPL. 3 (S496). Date of 
Publication: June 2010
VOLUME
  25
FIRST PAGE
  S496
DATE OF PUBLICATION
  June 2010
CONFERENCE NAME
  33rd Annual Meeting of the Society of General Internal Medicine
CONFERENCE LOCATION
  Minneapolis, MN, United States
CONFERENCE DATE
  2010-04-28 to 2010-05-01
ISSN
  0884-8734
BOOK PUBLISHER
  Springer New York
ABSTRACT
  LEARNING OBJECTIVE 1: To identify the causes of bilateral diaphragmatic 
paralysis. LEARNING OBJECTIVE 2: To explain how bilateral diaphragmatic 
paralysis causes respiratory failure and sleep disorders and discuss the 
therapeutic modalities employed in treating this disorder. CASE: An 86 year 
old male with a complex past medical history, including CHF, hypertension, 
COPD, along with presumed obstructive and central sleep apnea was admitted 
to our ICU with hypercarbic respiratory failure. Earlier that day he had 
undergone a colonoscopy as part of a work up for a 50 lb weight loss. On 
discharge he developed acute respiratory failure and altered mental status. 
ABG showed a pH of 7.05, PCO2 of 118, and PO2 of 280, on supplemental 
oxygen. He was treated with mechanical ventilation but continued to be 
symptomatic and was sent to an LTAC for rehabilitation. Over a period of 4 
months the patient had repeated episodes of respiratory failure requiring 
management with BIPAP and intubation. His baseline CO2 oscillated in the 
60's but rose to 130's during these episodes. The patient was exquisitely 
sensitive to benzodiazepines and could not tolerate being in the recumbent 
position; which frequently triggered his episodes. He was generally 
asymptomatic in the Fowler's position. Complete pulmonary function studies 
were performed, showing mild evidence of obstruction out of proportion with 
the significant reduction of his mechanics, with reduced mean inspiratory 
and expiratory pressures. CT of the brain and thorax failed to elucidate the 
underlying cause. An MRI was not obtained since the patient had a cardiac 
pacemaker. A sniff test performed under fluoroscopy revealed that both 
diaphragms were paralyzed and fixed in position without any paradoxical 
motion. Further exploration ensued and an EMG demonstrated evidence of a 
diffuse denervating process involving multiple cervical and lumbosacral 
myotomes, the overall picture being that of ALS. The patient declined 
tracheostomy with ventilator support. He was placed on continuous BIPAP 
therapy since it was thought that diaphragmatic pacing might not have been 
helpful given his other co morbidities. DISCUSSION: Bilateral diaphragmatic 
paralysis is a rare disease that can occur secondary to numerous processes. 
These include the immediate post operative phase of cardiac surgery 
(especially if ice was used for myocardial protection), traumas, mediastinal 
tumors, myelopathies, myopathies and non infectious polyneuropathies. 
Idiopatic forms have also been described. Since the diaphragm is the 
principal respiratory muscle, its paralysis has a significant effect on the 
ability of the respiratory system to adequately perform its function leading 
to respiratory distress and failure. It typically is accompanied by dyspnea, 
especially on exertion, and ortopnea. Because the respiratory distress is 
exaggerated in the supine position sleep disorders are common. The 
activities of the complimentary respiratory muscles decrease during the REM 
cycles compromising respiratory function. This provokes hypoxia and 
nocturnal hypercarbia which disturbs sleep and often leads to the 
misdiagnosis of obstructive and central sleep apnea. Functionally, bilateral 
diaphragmatic paralysis is characterized by a restrictive ventilatory defect 
with a decrease in FVC of 25% of more in the supine position as compared to 
being vertical. DLCO is typically preserved but MIP and MEP are usually 
reduced. Severe hypercarbia is rare if the disorder is isolated therefore, 
the search for other neuromuscular disorders such as ALS should be 
undertaken when present. Traditionally, severe cases have been treated with 
positive pressure ventilation via tracheostomy but recent reports have 
demonstrated equal efficacy and lower cost with NIPPV like BIPAP. 
Diaphragmatic pacing has also been used but its prohibitive cost and 
invasive nature makes it less of an attractive option.
EMTREE DRUG INDEX TERMS
  benzodiazepine derivative; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm paralysis; internal medicine; respiratory failure; society; 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure; artificial ventilation; body weight loss; brain; breathing muscle; central sleep apnea syndrome; colonoscopy; diagnostic error; diaphragm; dyspnea; electromyogram; exercise; fluoroscopy; heart surgery; hypercapnia; hypertension; hypoxia; injury; intubation; lung function; male; mechanics; mediastinum tumor; medical history; mental health; morbidity; myopathy; myotome; neuromuscular disease; nuclear magnetic resonance imaging; obstruction; paralysis; patient; pH; polyneuropathy; positive end expiratory pressure; protection; rare disease; rehabilitation; respiratory distress; respiratory function; respiratory system; sinus node; sleep; sleep disorder; supine position; therapy; thorax; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70315429
DOI
  10.1007/s11606-010-1338-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s11606-010-1338-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08848734&id=doi:10.1007%2Fs11606-010-1338-5&atitle=Bilateral+diaphragmatic+paralysis%3A+A+sinister+cause+of+respiratory+failure&stitle=J.+Gen.+Intern.+Med.&title=Journal+of+General+Internal+Medicine&volume=25&issue=&spage=S496&epage=&aulast=Smith&aufirst=Triston&auinit=T.&aufull=Smith+T.&coden=&isbn=&pages=S496-&date=2010&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 721
TITLE
  Mild pathological changes of ALS in spite of the longest clinical course
AUTHOR NAMES
  Mochizuki Y.; Shimizu T.; Mizutani T.
AUTHOR ADDRESSES
  (Mochizuki Y.; Mizutani T.) Dept. of Pathol., Tokyo Met. Neurol. Hosp., 
Japan.
(Shimizu T.) Dept. of Neurol., Tokyo Met. Neurol. Hosp., Japan.
(Mochizuki Y.) Dept. of Int. Med., Tokyo Met. Kita Med. and Rehabil. Ctr., 
Japan.
CORRESPONDENCE ADDRESS
  Y. Mochizuki, Dept. of Pathol., Tokyo Met. Neurol. Hosp., Japan.
FULL RECORD ENTRY DATE
  2011-06-27
SOURCE
  Neuropathology (2010) 30:3 (323). Date of Publication: June 2010
VOLUME
  30
ISSUE
  3
FIRST PAGE
  323
DATE OF PUBLICATION
  June 2010
CONFERENCE NAME
  51st Annual Meeting of the Japanese Society of Neuropathology
CONFERENCE LOCATION
  Tokyo, Japan
CONFERENCE DATE
  2010-04-23 to 2010-04-25
ISSN
  0919-6544
BOOK PUBLISHER
  Blackwell Publishing
ABSTRACT
  A 48-year-old man developed right hand weakness. The symptoms progressed 
very slowly. Tracheostomy positive pressure ventilation became occasionally 
needed about 13 years from the onset, and always necessary at 25 years from 
onset. Three years later he died of malignant lymphoma. The duration of this 
illness was 28 years and the longest among 126 autopsied ALS cases in our 
hospital. The brain weighed 1,190 g. Although the spinal cord was markedly 
atrophic, preserved motor neurons were scattered. In the pyramidal 
tracts,the large myelinated fibers were lost, whereas the small fibers were 
preserved. The other fibers in the spinal cord were well preserved despite 
the marked atrophy of the spinal cord. The TDP-43 positive inclusions and 
Bunina bodies were not found. Atrophy of the spinal cord was similar to that 
of other ALS cases with long duration. The major lesions of this case was 
limited to the motor system. The neuropathological findings described above 
were consistent with the clinical features of this patient.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  disease course; Japanese (people); neuropathology; society; 
EMTREE MEDICAL INDEX TERMS
  atrophy; brain; clinical feature; fiber; general aspects of disease; hospital; lymphoma; male; motoneuron; motor system; myelinated nerve; patient; positive end expiratory pressure; pyramidal tract; spinal cord; tracheostomy; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70443418
DOI
  10.1111/j.1440-1789.2010.01036.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1440-1789.2010.01036.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:10.1111%2Fj.1440-1789.2010.01036.x&atitle=Mild+pathological+changes+of+ALS+in+spite+of+the+longest+clinical+course&stitle=Neuropathology&title=Neuropathology&volume=30&issue=3&spage=323&epage=&aulast=Mochizuki&aufirst=Y.&auinit=Y.&aufull=Mochizuki+Y.&coden=&isbn=&pages=323-&date=2010&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 722
TITLE
  Transnasal odontoid resection followed by posterior decompression and 
occipitocervical fusion in children with Chiari malformation Type I and 
ventral brainstem compression
AUTHOR NAMES
  Hankinson T.C.; Grunstein E.; Gardner P.; Spinks T.J.; Anderson R.C.E.
AUTHOR ADDRESSES
  (Hankinson T.C., tch12@columbia.edu; Anderson R.C.E.) Department of 
Neurosurgery, Columbia University, College of Physicians and Surgeons, New 
York, NY, United States.
(Grunstein E.) Department of Otolaryngology-Head and Neck Surgery, New York 
Presbyterian Hospital, Columbia University, New York, NY, United States.
(Gardner P.) Department of Neurological Surgery, University of Pittsburgh 
Medical Center Presbyterian, Pittsburgh, PA, United States.
(Spinks T.J.) Department of Neurosurgery, Scott and White Neurosciences 
Institute, Texas A and M College of Medicine, Temple, TX, United States.
CORRESPONDENCE ADDRESS
  T. C. Hankinson, Division of Pediatric Neurosurgery, Children's Hospital of 
Alabama, University of Alabama Birmingham, 1600 7th Avenue South, 
Birmingham, AL 35233, United States. Email: tch12@columbia.edu
AiP/IP ENTRY DATE
  2010-06-14
FULL RECORD ENTRY DATE
  2010-06-16
SOURCE
  Journal of Neurosurgery: Pediatrics (2010) 5:6 (549-553). Date of 
Publication: June 2010
VOLUME
  5
ISSUE
  6
FIRST PAGE
  549
LAST PAGE
  553
DATE OF PUBLICATION
  June 2010
ISSN
  1933-0707
  1933-0715 (electronic)
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Object. In rare cases, children with a Chiari malformation Type I (CM-I) 
suffer from concomitant, irreducible, ventral brainstem compression that may 
result in cranial neuropathies or brainstem dysfunction. In these 
circumstances, a 360° decompression supplemented by posterior stabilization 
and fusion is required. In this report, the authors present the first 
experience with using an endoscopic transnasal corridor to accomplish 
ventral decompression in children with CM-I that is complicated by ventral 
brainstem compression. Methods. Two children presented with a combination of 
occipital headaches, swallowing dysfunction, myelopathy, and/or progressive 
scoliosis. Imaging studies demonstrated CM-I with severely retroflexed 
odontoid processes and ventral brainstem compression. Both patients 
underwent an endoscopic transnasal approach for ventral decompression, 
followed by posterior decompression, expansive duraplasty, and 
occipital-cervical fusion. Results. In both patients the endoscopic 
transnasal approach provided excellent ventral access to decompress the 
brainstem. When compared with the transoral approach, endoscopic transnasal 
access presents 4 potential advantages: 1) excellent prevertebral exposure 
in patients with small oral cavities; 2) a surgical corridor located above 
the hard palate to decompress rostral pathological entities more easily; 3) 
avoidance of the oral trauma and edema that follows oral retractor 
placement; and 4) avoidance of splitting the soft or hard palate in patients 
with oral-palatal dysfunction from ventral brainstem compression. 
Conclusions. The endoscopic transnasal approach is atraumatic to the oral 
cavity, and offers a more superior region of exposure when compared with the 
standard transoral approach. Depending on their comfort level with 
endoscopic surgical techniques, pediatric neurosurgeons should consider this 
approach in children with pathological entities requiring ventral brainstem 
decompression.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Arnold Chiari malformation (diagnosis, surgery); atlantooccipital fusion; brain decompression; brain disease; spine fusion; spine surgery; transnasal odontoid resection; ventral brainstem compression; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; basilar impression (complication); case report; child; computer assisted tomography; dysphagia; experience; hard palate; headache; human; laminectomy; male; mouth cavity; mouth edema; mouth injury; nuclear magnetic resonance imaging; odontoid process; priority journal; recurrent disease; school child; scoliosis; spinal cord disease; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Radiology (14)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010315800
MEDLINE PMID
  20515325 (http://www.ncbi.nlm.nih.gov/pubmed/20515325)
PUI
  L358950988
DOI
  10.3171/2010.2.PEDS09362
FULL TEXT LINK
  http://dx.doi.org/10.3171/2010.2.PEDS09362
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19330707&id=doi:10.3171%2F2010.2.PEDS09362&atitle=Transnasal+odontoid+resection+followed+by+posterior+decompression+and+occipitocervical+fusion+in+children+with+Chiari+malformation+Type+I+and+ventral+brainstem+compression&stitle=J.+Neursurg.+Pediatr.&title=Journal+of+Neurosurgery%3A+Pediatrics&volume=5&issue=6&spage=549&epage=553&aulast=Hankinson&aufirst=Todd+C.&auinit=T.C.&aufull=Hankinson+T.C.&coden=&isbn=&pages=549-553&date=2010&auinit1=T&auinitm=C
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 723
TITLE
  Safe performance of spinal anesthesia in a critical patient with 
neurofibromatosis, pectus carinatum, and temporomandibular joint 
dysfunction: A case report
AUTHOR NAMES
  Zencirci B.
AUTHOR ADDRESSES
  (Zencirci B., bzencirci@fastmail.fm) MOSTAS Private Health Hospital, 
Department of Anesthesiology and Reanimation, Kahramanmaras, Turkey.
CORRESPONDENCE ADDRESS
  B. Zencirci, MOSTAS Private Health Hospital, Department of Anesthesiology 
and Reanimation, Kahramanmaras, Turkey. Email: bzencirci@fastmail.fm
AiP/IP ENTRY DATE
  2011-07-25
FULL RECORD ENTRY DATE
  2011-08-03
SOURCE
  Patient Safety in Surgery (2010) 4:1 Article Number: 7. Date of Publication: 
3 May 2010
VOLUME
  4
ISSUE
  1
DATE OF PUBLICATION
  3 May 2010
ISSN
  1754-9493 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., 34 - 42 Cleveland Street, London, United Kingdom.
ABSTRACT
  Background: Neurofibromatosis is a syndrome caused by the abnormal 
deposition of neural tissues of the nervous system, endocrine system, 
visceral structures, and skin. On the other hand, pectus carinatum and 
temporomandibular joint dysfunction are illnesses that adversly affect the 
respiratory system and cause additional problems in airway management.Case 
Presentation: Fifty-eight-year-old Turkish male patient had 
neurofibromatosis, pectus carinatum and temporomandibular joint dysfunction. 
The case was due to be operated on with the diagnosis of incarcerated 
umbilical hernia. Spinal anesthesia was successfully performed and the 
duration of the surgery was 1 hour. No postoperative complications were 
observed and he was discharged from the hospital on the 3rd post-operative 
day.Conclusion: The anesthetic management of patients with neurofibromatosis 
requires attention to all possible abnormalities and associated 
disturbances. Furthermore, the presence of pectus carinatum and 
temporomandibular joint dysfunction also increase the potential risks. The 
operation was successfully completed with spinal anesthesia that was 
carefully applied upon taking the required measures and considering all 
pathologies that may accompany the case and complications that may occur. © 
2010 Zencirci; licensee BioMed Central Ltd.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  bupivacaine (intraspinal drug administration); 
EMTREE DRUG INDEX TERMS
  C reactive protein (endogenous compound); midazolam (intravenous drug administration); Ringer lactate solution; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neurofibromatosis; pigeon thorax; safety; spinal anesthesia; temporomandibular joint disorder; 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; anesthesia induction; article; blood pressure measurement; case report; electrocardiography; heart rate; heart right bundle branch block (diagnosis); hernia incarceration (surgery); human; intensive care unit; laboratory test; leukocytosis; male; operation duration; physical examination; postoperative period; premedication; preoperative evaluation; protein blood level; pulse oximetry; tracheostomy; 
CAS REGISTRY NUMBERS
  C reactive protein (9007-41-4)
  Ringer lactate solution (8022-63-7)
  bupivacaine (18010-40-7, 2180-92-9, 55750-21-5)
  midazolam (59467-70-8)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2011393427
PUI
  L362155534
DOI
  10.1186/1754-9493-4-7
FULL TEXT LINK
  http://dx.doi.org/10.1186/1754-9493-4-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17549493&id=doi:10.1186%2F1754-9493-4-7&atitle=Safe+performance+of+spinal+anesthesia+in+a+critical+patient+with+neurofibromatosis%2C+pectus+carinatum%2C+and+temporomandibular+joint+dysfunction%3A+A+case+report&stitle=Patient+Saf.+Surg.&title=Patient+Safety+in+Surgery&volume=4&issue=1&spage=&epage=&aulast=Zencirci&aufirst=Beyazit&auinit=B.&aufull=Zencirci+B.&coden=&isbn=&pages=-&date=2010&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 724
TITLE
  Survey of physician recommendation of long-term invasive ventilation for 
children with spinal muscular atrophy type I: Pilot survey
AUTHOR NAMES
  Benson R.C.; Hsia D.W.; Hardy K.A.
AUTHOR ADDRESSES
  (Benson R.C., rbenson@mail.cho.org; Hsia D.W.; Hardy K.A.) Children's 
Hospital, Research Center Oakland, Oakland, United States.
CORRESPONDENCE ADDRESS
  R.C. Benson, Children's Hospital, Research Center Oakland, Oakland, United 
States. Email: rbenson@mail.cho.org
FULL RECORD ENTRY DATE
  2012-08-27
SOURCE
  American Journal of Respiratory and Critical Care Medicine (2010) 181:1 
MeetingAbstracts. Date of Publication: 1 May 2010
VOLUME
  181
ISSUE
  1
DATE OF PUBLICATION
  1 May 2010
CONFERENCE NAME
  American Thoracic Society International Conference, ATS 2010
CONFERENCE LOCATION
  New Orleans, LA, United States
CONFERENCE DATE
  2010-05-14 to 2010-05-19
ISSN
  1073-449X
BOOK PUBLISHER
  American Thoracic Society
ABSTRACT
  Introduction: Spinal Muscular Atrophy Type I (SMA I) is a neurodegenerative 
disease that leads to progressive muscular weakness and ultimately death 
during infancy from chronic respiratory failure. There is considerable 
debate regarding the ethics of invasive mechanical ventilation for SMA I 
patients, who eventually become “locked-in” and are unable to communicate 
pain or discomfort. We conducted this pilot survey to determine which 
interventions physicians recommend for respiratory care of SMA I, and to 
assess awareness of consensus guidelines published by the International 
Standard of Care Committee for Spinal Muscular Atrophy in 2007. Methods: 
This was a descriptive cross-sectional survey of 34 pediatric pulmonologists 
and intensivists present at the 2009 Northern California Pediatric Intensive 
Care Network conference. Questions explored physician demographics, 
attitudes and experience with SMA and end-of-life care, knowledge of 
consensus guidelines, and recommendations for respiratory care of SMA I. 
Results: 10 pediatric pulmonologists and 24 intensivists were surveyed, 
including 8 fellows and 26 attendings. Results summarized in table below. 
41% of physicians were aware of consensus guidelines. 97% informed their 
patients about the option of noninvasive ventilation (NIV) for chronic 
respiratory failure, but only 24% recommended this intervention. While 91% 
informed their patients about the option of tracheostomy/invasive 
ventilation for chronic respiratory failure, only 32% felt this was an 
acceptable intervention, and only 6% recommended this intervention. Despite 
this, 59% felt that physicians do not have the right to refuse 
tracheostomy/invasive ventilation for SMA I patients. Conclusions: We found 
that the majority of physicians surveyed opposed tracheostomy and invasive 
ventilation for SMA I, although most felt that it was not right for the 
physician to refuse this intervention if requested. Fewer physicians in this 
pilot survey recommended tracheostomy and invasive ventilation than prior 
surveys in the literature. A much larger international survey is underway to 
identify regional practice differences that may contribute to variability of 
care for SMA I. By highlighting these differences and how they contribute to 
medical decision-making, we aim to encourage dialogue amongst physicians 
that will ultimately improve standardization of respiratory care for SMA I, 
reduce costly invasive interventions, and minimize suffering of patients and 
families. (Table presented).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  air conditioning; child; human; physician; society; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; chronic respiratory failure; consensus; death; degenerative disease; ethics; health care quality; infancy; intensive care; medical decision making; muscle weakness; noninvasive ventilation; pain; patient; respiratory care; standardization; terminal care; tracheostomy; United States; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70840777
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1073449X&id=doi:&atitle=Survey+of+physician+recommendation+of+long-term+invasive+ventilation+for+children+with+spinal+muscular+atrophy+type+I%3A+Pilot+survey&stitle=Am.+J.+Respir.+Crit.+Care+Med.&title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&volume=181&issue=1&spage=&epage=&aulast=Benson&aufirst=R.C.&auinit=R.C.&aufull=Benson+R.C.&coden=&isbn=&pages=-&date=2010&auinit1=R&auinitm=C
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 725
TITLE
  Utility of bedside ultrasound in the prediction of difficult airway
AUTHOR NAMES
  Adhikari S.R.; Zeger W.; Craven I.; Crum T.; Schmier C.; Pang H.; Frrokaj I.
AUTHOR ADDRESSES
  (Adhikari S.R.; Zeger W.; Craven I.; Crum T.; Schmier C.; Pang H.; Frrokaj 
I.) University of Nebraska Medical Center, Christiana Health Care System
FULL RECORD ENTRY DATE
  2014-08-31
SOURCE
  Academic Emergency Medicine (2010) 17 SUPPL. 1 (S194). Date of Publication: 
May 2010
VOLUME
  17
FIRST PAGE
  S194
DATE OF PUBLICATION
  May 2010
CONFERENCE NAME
  2010 Annual Meeting of the Society for Academic Emergency Medicine, SAEM 
2010
CONFERENCE LOCATION
  Phoenix, AZ, United States
CONFERENCE DATE
  2010-06-03 to 2010-06-06
ISSN
  1069-6563
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  Objective: Prediction of difficult laryngoscopy (DL) in emergency department 
(ED) patients with altered mental status is challenging. Common screening 
tests for DL cannot be applied in emergency intubations of these patients. 
The objective of this study is to assess the utility of bedside ultrasound 
(US) to predict DL. Methods: Prospective group sequential study at an 
academic medical center. Inclusion criteria: Adult patients undergoing 
endotracheal intubation prior to any surgery. Exclusion criteria: Patients 
with upper airway pathologies, cervical spine fractures, and tracheostomy 
tube. Patients were enrolled on randomly chosen study days. The following 
variables were collected preoperatively: BMI, dental abnormalities, 
thyromental distance, TMJ mobility, neck movements, modified Mallampati 
scale, and neck circumference. An emergency physician sonologist blinded to 
above variables obtained US measurements of base of the tongue and anterior 
neck soft tissue thickness at hyoid bone (HBSTT), thyrohyoid membrane 
(THMSTT), and vocal cords (VCSTT) levels. Laryngoscopy view was graded using 
Cormack and Lehane classification by anesthesiologists blinded to US 
measurements. The Kruskal-Wallis test was used to examine the associations. 
The Wilcoxon test was used for pairwise comparisons. Results: Forty-six 
patients were enrolled in the study (female-30, male-16). The mean age was 
54 years +/- 12.6 (SD). 6/46 (13%, 95% CI 3-27%) of patients were classified 
as having DL by anesthesiologists. The sonographic measurement of HBSTT was 
significantly higher in the DL group compared to the easy laryngoscopy group 
(p=0.02). US measurements of the base of the tongue and THMSTT were also 
high in patients with DL. US measurements correlated better with DL than 
Mallampati classification and thyromental distance. Conclusions: In our 
pilot study, US measurement of anterior neck soft tissue thickness at hyoid 
bone level appears to be a good predictor of DL.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway; emergency medicine; prediction; society; ultrasound; 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesist; bone level; cervical spine fracture; classification; emergency; emergency physician; emergency ward; endotracheal intubation; female; human; hyoid bone; intubation; Kruskal Wallis test; laryngoscopy; male; membrane; mental health; neck; neck circumference; pathology; patient; pilot study; rank sum test; screening test; soft tissue; surgery; thickness; tongue; tracheostomy tube; university hospital; upper respiratory tract; vocal cord; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71596957
DOI
  10.1111/j.1553-2712.2010.00743.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1553-2712.2010.00743.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10696563&id=doi:10.1111%2Fj.1553-2712.2010.00743.x&atitle=Utility+of+bedside+ultrasound+in+the+prediction+of+difficult+airway&stitle=Acad.+Emerg.+Med.&title=Academic+Emergency+Medicine&volume=17&issue=&spage=S194&epage=&aulast=Adhikari&aufirst=Srikar+R.&auinit=S.R.&aufull=Adhikari+S.R.&coden=&isbn=&pages=S194-&date=2010&auinit1=S&auinitm=R
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 726
TITLE
  Long-Term Survival After Open Repair of Chronic Distal Aortic Dissection
AUTHOR NAMES
  Zoli S.; Etz C.D.; Roder F.; Mueller C.S.; Brenner R.M.; Bodian C.A.; Di Luozzo G.; Griepp R.B.
AUTHOR ADDRESSES
  (Zoli S., stefanozoli@gmail.com; Etz C.D.; Roder F.; Mueller C.S.; Brenner 
R.M.; Di Luozzo G.; Griepp R.B.) Department of Cardiothoracic Surgery, Mount 
Sinai School of Medicine, New York, NY, United States.
(Bodian C.A.) Department of Anesthesiology, Mount Sinai School of Medicine, 
New York, NY, United States.
CORRESPONDENCE ADDRESS
  S. Zoli, Department of Cardiothoracic Surgery, Mount Sinai School of 
Medicine, New York, NY, United States. Email: stefanozoli@gmail.com
AiP/IP ENTRY DATE
  2010-06-14
FULL RECORD ENTRY DATE
  2010-06-25
SOURCE
  Annals of Thoracic Surgery (2010) 89:5 (1458-1466). Date of Publication: May 
2010
VOLUME
  89
ISSUE
  5
FIRST PAGE
  1458
LAST PAGE
  1466
DATE OF PUBLICATION
  May 2010
ISSN
  0003-4975
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background: The optimal treatment of chronic distal aortic dissection 
remains controversial, with endovascular stent-graft techniques challenging 
traditional surgery. Methods: From January 1994 to April 2007, 104 patients 
(82 male, median age 60.5 years) with chronic distal aortic dissection 
underwent surgical repair, 0 to 21 years after initial diagnosis of acute 
type A or B dissection (median 2.1 years). Twenty-three (22%) patients 
underwent urgent-emergent surgery. Mean aortic diameter was 6.9 ± 1.4 cm. 
Indications for surgery, other than aortic expansion, were pain in 6 (6%) 
patients, malperfusion in 6 (6%), and rupture in 11 (11%). Forty-nine (47%) 
had previous cardioaortic surgery (29% dissection-related), 21 (20%) had 
coronary artery disease, 12 (12%) had Marfan syndrome, and 4 (4%) were on 
chronic dialysis. Twenty-six (25%) had a thrombosed false lumen. Thirty 
(29%) patients required reimplantation of visceral arteries; 8.3 ± 2.7 
segmental artery pairs were sacrificed. Results: Hospital mortality was 9.6% 
(10 patients). Paraplegia occurred in 5 (4.8%). Twenty-seven patients (26%) 
experienced adverse outcome (death within one year, paraplegia, stroke, or 
dialysis). Adverse outcome was associated with atheroma (p = 0.04, odds 
ratio = 4.3). Survival was 78% at 1, 68% at 5, and 59% at 10 years (average 
follow-up, 7.7 ± 4.1 years). Freedom from distal aortic reoperation was 99% 
at 1, 93% at 5, and 83% at 10 years. After one year, patients enjoyed 
longevity equivalent to a normal age-sex matched population (standardized 
mortality ratio = 1.38, p = 0.23). By multivariate analysis, atheroma (p = 
0.0005, relative risk = 9.32) and age (p = 0.0003, relative risk = 
1.15/year) were risk factors for long-term survival. Conclusions: The 
efficacy of open repair for distal chronic dissection is highlighted by 
normal survival after the first year, and a low reoperation-reintervention 
rate. © 2010 The Society of Thoracic Surgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic dissection (surgery); aortic surgery; chronic distal aortic dissection (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; adverse outcome; aged; aorta; article; atheroma (complication); cerebrovascular accident (complication); cohort analysis; coronary artery disease; dialysis; emergency surgery; female; follow up; heart arrest (complication); human; longevity; lung complication (complication, surgery); major clinical study; male; Marfan syndrome; mortality; multivariate analysis; overall survival; paraplegia (complication); postoperative complication (complication); priority journal; reimplantation; reoperation; risk factor; spinal cord injury (complication); survival time; thrombosis (complication); tracheotomy; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010316970
MEDLINE PMID
  20417761 (http://www.ncbi.nlm.nih.gov/pubmed/20417761)
PUI
  L358953258
DOI
  10.1016/j.athoracsur.2010.02.014
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2010.02.014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2Fj.athoracsur.2010.02.014&atitle=Long-Term+Survival+After+Open+Repair+of+Chronic+Distal+Aortic+Dissection&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=89&issue=5&spage=1458&epage=1466&aulast=Zoli&aufirst=Stefano&auinit=S.&aufull=Zoli+S.&coden=ATHSA&isbn=&pages=1458-1466&date=2010&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 727
TITLE
  From case to case: nursing patients with a tracheostomy
ORIGINAL (NON-ENGLISH) TITLE
  Von Fall zu Fall: Die Pflege von Menschen mit einem Tracheostoma.
AUTHOR NAMES
  Messer M.
AUTHOR ADDRESSES
  (Messer M.)
CORRESPONDENCE ADDRESS
  M. Messer,
FULL RECORD ENTRY DATE
  2010-07-26
SOURCE
  Pflege Zeitschrift (2010) 63:5 (310-311). Date of Publication: May 2010
VOLUME
  63
ISSUE
  5
FIRST PAGE
  310
LAST PAGE
  311
DATE OF PUBLICATION
  May 2010
ISSN
  0945-1129
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; in service training; long term care; nursing home; paraplegia; spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; human; male; nursing; 
LANGUAGE OF ARTICLE
  German
MEDLINE PMID
  20521467 (http://www.ncbi.nlm.nih.gov/pubmed/20521467)
PUI
  L359191038
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09451129&id=doi:&atitle=From+case+to+case%3A+nursing+patients+with+a+tracheostomy&stitle=Pflege+Z&title=Pflege+Zeitschrift&volume=63&issue=5&spage=310&epage=311&aulast=Messer&aufirst=Melanie&auinit=M.&aufull=Messer+M.&coden=&isbn=&pages=310-311&date=2010&auinit1=M&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 728
TITLE
  A national survey of paediatric long-term ventilation in the UK
AUTHOR NAMES
  Wallis C.; Jardine E.; Beaton S.; Paton J.
AUTHOR ADDRESSES
  (Wallis C.) Respiratory Unit, Great Ormond Street Hospital NHS Trust, 
London, United Kingdom.
(Jardine E.) Home Ventilation Service, Royal Hospital for Sick Children, 
Glasgow, United Kingdom.
(Beaton S.) Faculty of Medicine, University of Glasgow, Glasgow, United 
Kingdom.
(Paton J.) Department of Child Health, Royal Hospital for Sick Children, 
Glasgow, United Kingdom.
CORRESPONDENCE ADDRESS
  C. Wallis, Respiratory Unit, Great Ormond Street Hospital NHS Trust, London, 
United Kingdom.
FULL RECORD ENTRY DATE
  2011-03-29
SOURCE
  Archives of Disease in Childhood (2010) 95 SUPPL. 1 (A2). Date of 
Publication: April 2010
VOLUME
  95
FIRST PAGE
  A2
DATE OF PUBLICATION
  April 2010
CONFERENCE NAME
  Royal College of Paediatrics and Child Health Annual Conference, RCPCH 2010
CONFERENCE LOCATION
  Coventry, United Kingdom
CONFERENCE DATE
  2010-04-20 to 2010-04-22
ISSN
  0003-9888
BOOK PUBLISHER
  BMJ Publishing Group
ABSTRACT
  Aims: The last decade has seen a significant increase in the number of 
children receiving long-term ventilatory (LTV) support. There are a number 
of reasons for this including improved home ventilators for children, better 
designed paediatric face masks and a new ethos for long-term respiratory 
support at home. A previous survey undertaken in 1997 revealed 136 such 
children. The current number and status are required for allocation of 
healthcare resources for these high-cost, complex children. Methods: Because 
of the protean nature of this cohort, it was elected to do a spot census. A 
standard questionnaire was devised by consensus and 39 lead clinicians were 
identified who supervise children on LTV in the UK. All children (<17 years) 
receiving ventilatory support for all/part of the 24-h day for a period of 
at least 3 months at midnight on the 30th September 2008 were included. Data 
were entered to an online form and after anonymisation and encryption were 
stored at a central data monitoring centre. Results: 944 children/young 
people were identified. 58% were male and 91% lived at home. 212 children 
were ventilated by tracheostomy while 714 used facial mask interface. Three 
children had phrenic nerve pacing in addition to a tracheostomy. 18 were 
unknown. The medical causes for ventilatory support were divided into three 
main categories: Respiratory: (350) of which upper airway obstruction and 
obesity dominated; 11 had chronic lung disease of prematurity; CNS: (184) of 
which 57 had congenital central hypoventilation, 22 had high spinal injury; 
21 acquired hypoventilation; Musculoskeletal: (410) the commonest cause was 
Duchenne muscular dystrophy (92); 64 children had spinal muscular atrophy 
(SMA) type II and 12 SMA type I. Conclusions: This study has shown a very 
substantial increase in the numbers of children on LTV since the last UK 
survey. The increased use of non-invasive ventilation in neuromuscular 
patients is the main contributor. The vast majority of the children 
(including those on 24-h tracheostomy ventilation) are managed at home. 
These data will inform future health provision and also form the basis for a 
wider study into other aspect of home ventilation in childhood.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  air conditioning; child health; college; pediatrics; United Kingdom; 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; central nervous system; child; childhood; chronic lung disease; consensus; Duchenne muscular dystrophy; face mask; health; health care; hypoventilation; male; monitoring; obesity; patient; phrenic nerve; population research; prematurity; questionnaire; spinal muscular atrophy; spine injury; tracheostomy; upper respiratory tract obstruction; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70367703
DOI
  10.1136/adc.2010.186338.4
FULL TEXT LINK
  http://dx.doi.org/10.1136/adc.2010.186338.4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039888&id=doi:10.1136%2Fadc.2010.186338.4&atitle=A+national+survey+of+paediatric+long-term+ventilation+in+the+UK&stitle=Arch.+Dis.+Child.&title=Archives+of+Disease+in+Childhood&volume=95&issue=&spage=A2&epage=&aulast=Wallis&aufirst=C.&auinit=C.&aufull=Wallis+C.&coden=&isbn=&pages=A2-&date=2010&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 729
TITLE
  Dysphagia in acute tetraplegics: A retrospective study
AUTHOR NAMES
  Seidl R.O.; Nusser-Müller-Busch R.; Kurzweil M.; Niedeggen A.
AUTHOR ADDRESSES
  (Seidl R.O., ROSeidl@UKB.DE; Kurzweil M.) Department of Otolaryngology at 
Unfallkrankenhaus, Warener Straße 7, Berlin D-12683, Germany.
(Nusser-Müller-Busch R.) Department of Speech Language Therapy at 
Unfallkrankenhaus, Berlin, Germany.
(Niedeggen A.) Spinal Cord Injury Center at Unfallkrankenhaus, Berlin, 
Germany.
CORRESPONDENCE ADDRESS
  R. O. Seidl, Department of Otolaryngology, Unfallkrankenhaus Berlin, 
University of Berlin, Warener Straße 7, Berlin D-12683, Germany. Email: 
ROSeidl@UKB.DE
AiP/IP ENTRY DATE
  2010-03-17
FULL RECORD ENTRY DATE
  2010-04-21
SOURCE
  Spinal Cord (2010) 48:3 (197-201). Date of Publication: March 2010
VOLUME
  48
ISSUE
  3
FIRST PAGE
  197
LAST PAGE
  201
DATE OF PUBLICATION
  March 2010
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Retrospective study. Objectives: Swallowing disorder in 
patients with tetraplegia represents a problem. Incidence and clinical data 
were examined to determine the influencing factors. Setting: Level I trauma 
Center, Berlin, Germany. Method: Retrospective study (1 September 1997-31 
December 2002) on hospitalized patients with acute tetraplegia. The patients 
swallowing ability was examined both clinically and endoscopically, and the 
results correlated with clinical data. Results: A total of 175 patients (144 
(82.29%) male patients and 31 (17.71%) female patients (4.6:1) were studied. 
The peak age groups (43.45, ± 18.98, 14-89 years) were 20-30 years and over 
60 years. C4-C6 were most commonly affected. Tetraplegia was trauma-related 
in 147 (84%) patients. Twenty-eight (16.0%) patients appeared to be 
suffering from a swallowing disorder on first feeding, 23 (82.14%) patients 
with dysphagia were tracheotomized. The level of tetraplegia (x(2)=19.8; 
P<0.05), tracheotomy (x(2) 21.7; P;t;0.05) and the duration of ventilation 
(X(2) 24.84, P<0.05) were all found to be statistically significant factors 
in the development of a swallowing disorder. Age, surgical approach, level 
of tetraplegia, severity of paralysis and the need for tracheotomy were 
predictive of dysphagia in 73.14% patients. Five patients with dysphagia 
died (because of causes other than dysphagia) and 10 patients were 
discharged with a feeding tube. Conclusion: No single trigger for a 
swallowing disorder in acute tetraplegia was found. A combination of 
multiple factors (level of tetraplegia, severity of paralysis, tracheotomy, 
accompanying injuries and accompanying illnesses) restricts swallowing and 
compensation of changes, to the extent that a swallowing disorder becomes 
apparent. © 2010 International Spinal Cord Society All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia; quadriplegia (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  acute disease; adolescent; adult; aged; article; artificial ventilation; cause of death; cervical spine injury; clinical examination; disease association; disease severity; esophagoscopy; feeding; feeding apparatus; female; Germany; groups by age; hospital patient; human; major clinical study; male; priority journal; retrospective study; risk factor; spine fracture; surgical approach; swallowing; tracheotomy; treatment duration; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010159190
MEDLINE PMID
  19668256 (http://www.ncbi.nlm.nih.gov/pubmed/19668256)
PUI
  L50609082
DOI
  10.1038/sc.2009.102
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2009.102
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2009.102&atitle=Dysphagia+in+acute+tetraplegics%3A+A+retrospective+study&stitle=Spinal+Cord&title=Spinal+Cord&volume=48&issue=3&spage=197&epage=201&aulast=Seidl&aufirst=R.O.&auinit=R.O.&aufull=Seidl+R.O.&coden=SPCOF&isbn=&pages=197-201&date=2010&auinit1=R&auinitm=O
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 730
TITLE
  The choice of plain tracheostomy tube for long-term ventilation in adults: 
22 Years of domiciliary ventilation for high tetraplegia
AUTHOR NAMES
  Singaravelu S.K.; Watt J.W.H.
AUTHOR ADDRESSES
  (Singaravelu S.K.) Department of Anaesthesia and Intensive Care, Wirral 
University Teaching Hospital NHS Foundation Trust, Wirral, United Kingdom.
(Watt J.W.H., johnwhwatt@mauriceg.demon.co.uk) Northwest Regional Spinal 
Injuries Centre, Southport and Ormskirk Hospital NHS Trust, Southport PR8 
6PN, United Kingdom.
CORRESPONDENCE ADDRESS
  J. W. H. Watt, Northwest Regional Spinal Injuries Centre, Southport and 
Ormskirk Hospital NHS Trust, Southport PR8 6PN, United Kingdom. Email: 
johnwhwatt@mauriceg.demon.co.uk
AiP/IP ENTRY DATE
  2010-07-22
FULL RECORD ENTRY DATE
  2010-07-26
SOURCE
  British Journal of Intensive Care (2010) 20:1 (10-15). Date of Publication: 
Spring 2010
VOLUME
  20
ISSUE
  1
FIRST PAGE
  10
LAST PAGE
  15
DATE OF PUBLICATION
  Spring 2010
ISSN
  0961-7930
BOOK PUBLISHER
  Greycoat Publishing, 120 Dawes Road, London, United Kingdom.
ABSTRACT
  Background: Long-term invasive ventilation with an uncuffed tracheostomy 
tube requires that the tube be selected with care to avoid complication and 
ensure comfort, and provide sufficient insufflation leak for speech whilst 
avoiding hypoventilation. Aim/Patients and methods: A retrospective review 
was undertaken to help define characteristics in common among 64 adult 
patients on domiciliary ventilation discharged from the Northwest Regional 
Spinal Injuries Centre between 1983 and 2005. All but four receiving 
ventilation with room air had plain tracheostomy tubes. Radiography in the 
coronal and sagittal views had usually been to aid selection of a tube, 
sufficient in size to prevent nocturnal hypoventilation, and to match the 
tube curvature to the patient's anatomy. Measurements of the tube size and 
trachea from the radiological images were made using a Vernier calliper to 
correct for magnification. Results: In males, the median tracheostomy tube 
inside diameter was 8.0 mm (range 6-11 mm), and in females 7.5 mm (range 6-8 
mm). The mean calibre reduction ratio between trachea and tube outside 
diameter was 0.58. A total of eight different types of tracheostomy tubes 
have been used in order to match the patients' anatomy and ventilation 
requirements.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; quadriplegia (therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; ambient air; article; female; human; hypoventilation; long term care; major clinical study; male; radiography; retrospective study; room ventilation; spine injury; tube; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010387292
PUI
  L359168579
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09617930&id=doi:&atitle=The+choice+of+plain+tracheostomy+tube+for+long-term+ventilation+in+adults%3A+22+Years+of+domiciliary+ventilation+for+high+tetraplegia&stitle=Br.+J.+Intensive+Care&title=British+Journal+of+Intensive+Care&volume=20&issue=1&spage=10&epage=15&aulast=Singaravelu&aufirst=S.K.&auinit=S.K.&aufull=Singaravelu+S.K.&coden=BJICE&isbn=&pages=10-15&date=2010&auinit1=S&auinitm=K
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 731
TITLE
  Lateral Mediastinal Tracheostomy in Benign Disease: An Uncommon Procedure 
for a Rare Indication
AUTHOR NAMES
  Deslauriers N.; Jacques F.; Danino A.; Harris P.; Martin J.; Liberman M.; Duranceau A.; Ferraro P.
AUTHOR ADDRESSES
  (Deslauriers N.; Jacques F.; Martin J.; Liberman M.; Duranceau A.; Ferraro 
P., pasquale.ferraro@umontreal.ca) Division of Thoracic Surgery, Centre 
Hospitalier, l'Université de Montréal, Montréal, Que., Canada.
(Danino A.; Harris P.) Division of Plastic and Reconstructive Surgery, 
Department of Surgery, Centre Hospitalier, Montréal, Que., Canada.
CORRESPONDENCE ADDRESS
  P. Ferraro, Division of Thoracic Surgery, Centre Hospitalier, l'Université 
de Montréal, Montréal, Que., Canada. Email: pasquale.ferraro@umontreal.ca
AiP/IP ENTRY DATE
  2010-02-24
FULL RECORD ENTRY DATE
  2010-04-06
SOURCE
  Annals of Thoracic Surgery (2010) 89:3 (979-981). Date of Publication: March 
2010
VOLUME
  89
ISSUE
  3
FIRST PAGE
  979
LAST PAGE
  981
DATE OF PUBLICATION
  March 2010
ISSN
  0003-4975
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Tracheostomy is sometimes required for long-term ventilation in patients 
with a challenging cervical anatomy. We present a case of a patient 
requiring prolonged mechanical ventilation with prohibitive cervical anatomy 
for standard tracheostomy secondary to severe ankylosing spondylitis and a 
cervical spine fracture. © 2010 The Society of Thoracic Surgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis; cervical spine fracture; respiratory distress (surgery, therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; case report; computer assisted tomography; human; male; nasotracheal intubation; priority journal; surgical technique; treatment indication; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010115425
MEDLINE PMID
  20172176 (http://www.ncbi.nlm.nih.gov/pubmed/20172176)
PUI
  L358308853
DOI
  10.1016/j.athoracsur.2009.06.120
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.athoracsur.2009.06.120
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2Fj.athoracsur.2009.06.120&atitle=Lateral+Mediastinal+Tracheostomy+in+Benign+Disease%3A+An+Uncommon+Procedure+for+a+Rare+Indication&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=89&issue=3&spage=979&epage=981&aulast=Deslauriers&aufirst=Nancy&auinit=N.&aufull=Deslauriers+N.&coden=ATHSA&isbn=&pages=979-981&date=2010&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 732
TITLE
  Laryngeal fracture in a pediatric patient
AUTHOR NAMES
  Abdallah C.; Morrow M.; Jaryszak E.; Shah R.K.
AUTHOR ADDRESSES
  (Abdallah C.; Morrow M.) Anesthesiology, Children's National Medical Centre, 
Washington, United States.
(Jaryszak E.; Shah R.K.) Otorhinolaryngology, Children's National Medical 
Centre, Washington, United States.
CORRESPONDENCE ADDRESS
  C. Abdallah, Anesthesiology, Children's National Medical Centre, Washington, 
United States.
FULL RECORD ENTRY DATE
  2015-02-23
SOURCE
  Anesthesia and Analgesia (2010) 110:3 SUPPL. 1 (S120). Date of Publication: 
March 2010
VOLUME
  110
ISSUE
  3
FIRST PAGE
  S120
DATE OF PUBLICATION
  March 2010
CONFERENCE NAME
  2010 Annual Meeting of the International Anesthesia Research Society, IARS 
2010
CONFERENCE LOCATION
  Honolulu, HI, United States
CONFERENCE DATE
  2010-03-20 to 2010-03-23
ISSN
  0003-2999
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction : Open or closed injuries to the larynx and trachea can occur 
from direct trauma but are unusual in children due to the relatively high 
position of the larynx in the neck. Closed injury is associated with high 
prehospital mortality. Case Report : A 10 year old boy had fallen onto a 
park bench striking his neck. He was sent home with mild pain in his neck. 
Later that evening, he had shortness of breath, tachypnea, voice change and 
episodes of non bloody emesis. He was taken to a local hospital and 
immediately transferred to a tertiary care academic medical center. Physical 
examination was notable for signs of abrasion on the anterior neck, and the 
presence of significant crepitus in the upper chest. A computed tomography 
showed laryngeal rupture with extensive subcutaneous air tracking into the 
mediastinum. As the pediatric laryngeal framework is cartilaginous, 
fractures were not able to be radiographically discerned. Cervical spine 
injury was ruled out. A flexible nasopharyngolarngoscopy demonstrated a 
patent airway. The patient was brought to the operating room, spontaneously 
breathing. Premedication with intravenous midazolam 0.05 mg/kg was 
administered. Anesthesia was initiated with sevoflurane in O2, fentanyl 1 
mcg /kg and propofol 1.5 mg/ kg to keep the patient spontaneously breathing 
and anesthetized. Anesthesia was maintained with an intravenous propofol 
infusion at 300 mcg/kg/min. A Parsons laryngoscope was used to cannulate the 
upper airway. It was grade 1 view. Topical lidocaine was sprayed. There was 
massive edema of the left vocal fold with hematoma and ecchymosis in the 
ventricle. Bronchoscopy and rigid esophagoscopy did not show evidence of 
esophageal injury or trauma. The patient was atraumatically intubated with a 
5 mm ID endotracheal tube. The neck was explored, there was a fracture 
extending from the laryngeal prominence of the thyroid cartilage inferiorly, 
extending approximately 2 cm and deviating towards the left side. 
Approximation of the fractured wound edges was made (Fig. 1) and a Penrose 
drain placed. A conscious decision was made not to place a tracheostomy at 
this time. The patient tolerated the procedure well and was transferred 
intubated to the intensive care unit. A successful tracheal extubation after 
a direct laryngoscopy and bronchoscopy was done on post-operative day four. 
There were no complications. Discussion : Blunt trauma to the larynx is an 
uncommon, often fatal injury. Conventional management consists of awake 
tracheostomy (1). Spontaneous ventilation while maintaining adequate level 
of anesthesia and careful handling of the airway allowed direct repair of 
this laryngeal trauma. Excessive positive pressure by face mask, coughing, 
struggling, nitrous oxide, cricoid pressure, and overzealous attempts at 
intubation may result in further airway damage and should be avoided as were 
done in this case. (Figure presented) .
EMTREE DRUG INDEX TERMS
  fentanyl; lidocaine; midazolam; nitrous oxide; propofol; sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; fracture; human; patient; society; 
EMTREE MEDICAL INDEX TERMS
  abrasion; airway; blunt trauma; boy; breathing; bronchoscopy; case report; cervical spine injury; child; computer assisted tomography; coughing; cricoid cartilage; dyspnea; ecchymosis; edema; endotracheal tube; esophagoscopy; esophagus injury; extubation; face mask; hematoma; hospital; infusion; injury; intensive care unit; intubation; laryngoscope; laryngoscopy; larynx; larynx cartilage; larynx injury; male; mediastinum; mortality; neck; operating room; pain; patent; physical examination; premedication; procedures; rupture; tachypnea; tertiary health care; thorax; trachea; tracheostomy; university hospital; upper respiratory tract; vocal cord; voice change; vomiting; wound; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L71788344
DOI
  10.1213/01.ANE.0000398215.59935.49
FULL TEXT LINK
  http://dx.doi.org/10.1213/01.ANE.0000398215.59935.49
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032999&id=doi:10.1213%2F01.ANE.0000398215.59935.49&atitle=Laryngeal+fracture+in+a+pediatric+patient&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=110&issue=3&spage=S120&epage=&aulast=Abdallah&aufirst=C.&auinit=C.&aufull=Abdallah+C.&coden=&isbn=&pages=S120-&date=2010&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 733
TITLE
  Tracheal laceration associated with cervical spine injury-case report.
AUTHOR NAMES
  Sobiech S.; Onichimowski D.; Gawlikowska E.
AUTHOR ADDRESSES
  (Sobiech S.) Department of Anaesthesiology and Intensive Care, Regional 
Specialised Hospital, Olsztyn, Poland.
(Onichimowski D.; Gawlikowska E.)
CORRESPONDENCE ADDRESS
  S. Sobiech, Department of Anaesthesiology and Intensive Care, Regional 
Specialised Hospital, Olsztyn, Poland. Email: sebastian.sobiech5@wp.pl
FULL RECORD ENTRY DATE
  2010-10-29
SOURCE
  Ortopedia, traumatologia, rehabilitacja (2010) 12:2 (166-174). Date of 
Publication: 2010 Mar-Apr
VOLUME
  12
ISSUE
  2
FIRST PAGE
  166
LAST PAGE
  174
DATE OF PUBLICATION
  2010 Mar-Apr
ISSN
  1509-3492
ABSTRACT
  Mortality as a result of cervical spine injuries is predominantly associated 
with respiratory complications. Besides atelectasis, pneumonia, or 
respiratory failure, possible complications also include damage to 
anatomical structures of the respiratory tract. CASE REPORT: We present the 
case of a 44-year-old man who suffered a cervical spine injury with 
associated tracheal laceration after a fall from a height of about 2 meters. 
Vertebrae C3, C4, C5 were damaged with anterior dislocation at the C3/C4 
level. Because of the development of respiratory failure, the patient was 
intubated and mechanical ventilation was commenced. In view of a complete 
and irreversible spinal cord injury, the patient was not qualified for an 
emergency stabilisation of the vertebral fractures. Surgery was further 
delayed because of increasing signs of a respiratory infection. On the 12th 
ICU day, a perforation of the anterior tracheal wall was identified during 
an elective tracheotomy. Due to the presence of pus at the tracheostomy site 
and air leakage around the tracheostomy tube cuff, the patient was intubated 
with a double-lumen endotracheal tube. On the 23th ICU day, acute problems 
with mechanical ventilation developed due to persisting air leakage around 
the tube cuff accompanied by signs suggestive of a tracheo-oesophageal 
fistula. Replacement of the double-lumen tube with a single-lumen one and a 
bronchoscopy was followed by cardiac arrest. Resuscitation led to the return 
of circulation over four hours, followed by death of the patient in the 
setting of increasing shock. The cervical spine injury suffered by the 
patient can be classified as Magerl's B1.2.3 and additionally as a Category 
C injury. These are the most severe injuries which may be accompanied by 
tracheal or oesophageal damage. In such cases, it is advisable to carry out 
detailed work-up to detect any damage to structures adjacent to the spine, 
in particular the trachea and oesophagus. Early stabilisation of severe 
spinal fractures allows for intraoperative assessment of the adjacent 
structures. A delay in diagnosing damage to the trachea or oesophagus is 
associated with poorer prognosis and a potential inability to treat the 
injuries due to developing inflammatory complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine (surgery); laceration (etiology, surgery); spinal cord injury (complication, surgery); trachea (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; bronchoscopy; case report; endotracheal intubation; fatality; human; injury; male; methodology; radiography; respiratory tract infection (etiology, therapy); 
LANGUAGE OF ARTICLE
  English, Polish
MEDLINE PMID
  20453256 (http://www.ncbi.nlm.nih.gov/pubmed/20453256)
PUI
  L359808375
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15093492&id=doi:&atitle=Tracheal+laceration+associated+with+cervical+spine+injury-case+report.&stitle=Ortop+Traumatol+Rehabil&title=Ortopedia%2C+traumatologia%2C+rehabilitacja&volume=12&issue=2&spage=166&epage=174&aulast=Sobiech&aufirst=Sebastian&auinit=S.&aufull=Sobiech+S.&coden=&isbn=&pages=166-174&date=2010&auinit1=S&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 734
TITLE
  Author's reply to the Letter to the Editor of Chao Wang and Shenglin Wang 
(ESJO-D-09-00515) concerning "the single transoral approach for Os 
odontoideum with irreducible atlantoaxial dislocation" by Wang X, Fan CY, 
Liu ZH, Eur Spine J. 2009 Jul 14. [Epub ahead of print]
AUTHOR NAMES
  Liu Z.-H.
AUTHOR ADDRESSES
  (Liu Z.-H., liuzhenh@yahoo.com.cn) Department of Orthopaedic Surgery, First 
Affiliated Hospital, Bengbu Medical College, 287 ChangHuai Road, Bengbu, 
Anhui, China.
CORRESPONDENCE ADDRESS
  Z.-H. Liu, Department of Orthopaedic Surgery, First Affiliated Hospital, 
Bengbu Medical College, 287 ChangHuai Road, Bengbu, Anhui, China. Email: 
liuzhenh@yahoo.com.cn
AiP/IP ENTRY DATE
  2009-12-16
FULL RECORD ENTRY DATE
  2010-05-25
SOURCE
  European Spine Journal (2010) 19:3 (505-507). Date of Publication: March 
2010
VOLUME
  19
ISSUE
  3
FIRST PAGE
  505
LAST PAGE
  507
DATE OF PUBLICATION
  March 2010
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial dislocation; odontoid process; 
EMTREE MEDICAL INDEX TERMS
  bone screw; cervical spine; computer assisted tomography; fluoroscopy; human; letter; nuclear magnetic resonance imaging; osteosynthesis; priority journal; spinal cord decompression; spine fusion; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2010233764
PUI
  L50736034
DOI
  10.1007/s00586-009-1242-z
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-009-1242-z
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-009-1242-z&atitle=Author%27s+reply+to+the+Letter+to+the+Editor+of+Chao+Wang+and+Shenglin+Wang+%28ESJO-D-09-00515%29+concerning+%22the+single+transoral+approach+for+Os+odontoideum+with+irreducible+atlantoaxial+dislocation%22+by+Wang+X%2C+Fan+CY%2C+Liu+ZH%2C+Eur+Spine+J.+2009+Jul+14.+%5BEpub+ahead+of+print%5D&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=19&issue=3&spage=505&epage=507&aulast=Liu&aufirst=Zhen-Hua&auinit=Z.-H.&aufull=Liu+Z.-H.&coden=ESJOE&isbn=&pages=505-507&date=2010&auinit1=Z&auinitm=-H
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 735
TITLE
  Cervical tuberculous spondylodiscitis
ORIGINAL (NON-ENGLISH) TITLE
  Espondilodiscitis cervical tuberculosa
AUTHOR NAMES
  Sánchez Barrueco A.; Zayas Pavón G.; García Fernández A.
AUTHOR ADDRESSES
  (Sánchez Barrueco A., alvaro.sanchez.barrueco@gmail.com; Zayas Pavón G.; 
García Fernández A.) Servicio de Otorrinolaringología, Hospital 
Universitario 12 de Octubre, Madrid, Spain.
CORRESPONDENCE ADDRESS
  A. Sánchez Barrueco, Servicio de Otorrinolaringología, Hospital 
Universitario 12 de Octubre, Madrid, Spain. Email: 
alvaro.sanchez.barrueco@gmail.com
AiP/IP ENTRY DATE
  2009-10-16
FULL RECORD ENTRY DATE
  2010-03-12
SOURCE
  Acta Otorrinolaringologica Espanola (2010) 61:2 (168-169). Date of 
Publication: March 2010/April 2010
VOLUME
  61
ISSUE
  2
FIRST PAGE
  168
LAST PAGE
  169
DATE OF PUBLICATION
  March 2010/April 2010
ISSN
  0001-6519
BOOK PUBLISHER
  Ediciones Doyma, S.L., Travesera de Gracia 17-21, Barcelona, Spain.
EMTREE DRUG INDEX TERMS
  ethambutol (drug combination, drug therapy); isoniazid (drug combination, drug therapy); levofloxacin (drug combination); meropenem (drug combination); pyrazinamide (drug combination, drug therapy); rifampicin (drug combination, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical tuberculous spondylodiscitis (drug therapy, drug therapy); tuberculous spondylitis (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  aged; arm weakness; article; bacterium culture; case report; cervical myelopathy; cervical spine; cervicotomy; computer assisted tomography; epidural space; human; male; Mycobacterium tuberculosis; neurosurgery; nuclear magnetic resonance imaging; pain; spastic paraplegia; spinal cord compression; spine surgery; tracheotomy; tuberculin test; vertebra body; 
CAS REGISTRY NUMBERS
  ethambutol (10054-05-4, 1070-11-7, 3577-94-4, 74-55-5)
  isoniazid (54-85-3, 62229-51-0, 65979-32-0)
  levofloxacin (100986-85-4, 138199-71-0)
  meropenem (96036-03-2)
  pyrazinamide (98-96-4)
  rifampicin (13292-46-1)
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  Spanish
EMBASE ACCESSION NUMBER
  2010091100
MEDLINE PMID
  19818426 (http://www.ncbi.nlm.nih.gov/pubmed/19818426)
PUI
  L50667082
DOI
  10.1016/j.otorri.2009.03.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.otorri.2009.03.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016519&id=doi:10.1016%2Fj.otorri.2009.03.010&atitle=Cervical+tuberculous+spondylodiscitis&stitle=Acta+Otorrinolaringol.+Esp.&title=Acta+Otorrinolaringologica+Espanola&volume=61&issue=2&spage=168&epage=169&aulast=S%C3%A1nchez+Barrueco&aufirst=%C3%81lvaro&auinit=A.&aufull=S%C3%A1nchez+Barrueco+A.&coden=AOTEA&isbn=&pages=168-169&date=2010&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 736
TITLE
  Pediatric Rehabilitation: 2. Environmental Factors Affecting Participation
AUTHOR NAMES
  Murphy N.; Trovato M.; Kim H.; Kim C.T.; Moberg-Wolff E.
AUTHOR ADDRESSES
  (Murphy N., nancy.murphy@hsc.utah.edu) Division of General Pediatrics, 
University of Utah, PO Box 581289, Salt Lake City, UT 84158, United States.
(Trovato M.) Department of PM and R, Johns Hopkins University, School of 
Medicine, Baltimore, MD, United States.
(Kim H.) Department of PM and R and Pediatrics, University of Pennsylvania, 
School of Medicine, Philadelphia, PA, United States.
(Kim C.T.) Department of PM and R and Pediatrics, University of 
Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA, 
United States.
(Moberg-Wolff E.) Department of PM and R, Medical College of Wisconsin, 
Children's Hospital of Wisconsin, Milwaukee, WI, United States.
CORRESPONDENCE ADDRESS
  N. Murphy, Division of General Pediatrics, University of Utah, PO Box 
581289, Salt Lake City, UT 84158, United States. Email: 
nancy.murphy@hsc.utah.edu
AiP/IP ENTRY DATE
  2010-04-08
FULL RECORD ENTRY DATE
  2010-04-28
SOURCE
  PM and R (2010) 2:3 (S12-S18). Date of Publication: March 2010
VOLUME
  2
ISSUE
  3
DATE OF PUBLICATION
  March 2010
ISSN
  1934-1482
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Objective: This self-directed learning module highlights the environmental 
factors that influence the participation of children and youth with 
disabilities in life situations, including activities of self-care, 
mobility, socialization, education, recreation, and community life. It is 
part of the study guide on pediatric rehabilitation in the Self-Directed 
Physiatric Education Program for practitioners and trainees in physical 
medicine and rehabilitation and pediatric medicine. This module emphasizes 
the participation of children with disabilities in adapted sports and 
reviews mobility devices to promote function, in the context of the 
International Classification of Functioning and in reference to the 
Americans with Disabilities Act. It provides the physiatrist with strategies 
to promote community participation, functional independence and healthcare 
transitions for children with disabilities as they approach adulthood. The 
goal of this article is to improve the learner's treatment strategies to 
maximize the participation of children and youth with disabilities in all 
settings, particularly schools and communities. © 2010 American Academy of 
Physical Medicine and Rehabilitation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  environmental factor; patient participation; pediatric rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; backache; family counseling; fatigue; foster care; fracture; handicapped child; health insurance; hospital discharge; human; hydrocephalus; knee pain; leukodystrophy; myopathy (congenital disorder); obesity; paraplegia; patient care; priority journal; school; self concept; shoulder pain; spinal cord injury; spinal dysraphism (epidemiology); sport; stomach tube; tracheostomy; treatment planning; walking aid; wheelchair; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010198141
MEDLINE PMID
  20359674 (http://www.ncbi.nlm.nih.gov/pubmed/20359674)
PUI
  L358544287
DOI
  10.1016/j.pmrj.2009.12.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pmrj.2009.12.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19341482&id=doi:10.1016%2Fj.pmrj.2009.12.002&atitle=Pediatric+Rehabilitation%3A+2.+Environmental+Factors+Affecting+Participation&stitle=PM+R&title=PM+and+R&volume=2&issue=3&spage=&epage=&aulast=Murphy&aufirst=Nancy&auinit=N.&aufull=Murphy+N.&coden=&isbn=&pages=-&date=2010&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 737
TITLE
  Transoral approaches to the cervical spine
AUTHOR NAMES
  Hsu W.; Wolinsky J.-P.; Gokaslan Z.L.; Sciubba D.M.
AUTHOR ADDRESSES
  (Hsu W., weshsu@jhmi.edu; Wolinsky J.-P.; Gokaslan Z.L.; Sciubba D.M.) 
Department of Neurosurgery, Johns Hopkins University, School of Medicine, 
600 N. Wolfe Street, Baltimore, MD 21287, United States.
CORRESPONDENCE ADDRESS
  W. Hsu, Department of Neurosurgery, Johns Hopkins University, School of 
Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, United States. Email: 
weshsu@jhmi.edu
AiP/IP ENTRY DATE
  2010-03-10
FULL RECORD ENTRY DATE
  2010-04-19
SOURCE
  Neurosurgery (2010) 66:SUPPL. 3 (A119-A125). Date of Publication: March 2010
VOLUME
  66
ISSUE
  SUPPL. 3
DATE OF PUBLICATION
  March 2010
ISSN
  0148-396X
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  A NUMBER OF anterior approaches to the craniocervical junction have been 
described to allow exposure to the midline and lateral aspects of both the 
cranial base and upper cervical spine. The transoral-transpharyngeal 
approach, a technique that is well known to many spine surgeons, provides 
surgical access to the anterior clivus, C1, and C2. Transoral approaches 
provide the fundamental anatomy and technique upon which the more complex 
jaw-splitting approaches are based. This article discusses fundamental 
concepts regarding anatomy, perioperative considerations, and technical 
aspects critical to this important approach to the craniocervical junction. 
The transoral-transpharyngeal approach remains the "gold standard" for 
anterior approaches to the cervical spine. Endoscopic endonasal and 
endoscopic transcervical approaches are promising alternatives that may 
become more mainstream as experience with these approaches increases. 
Copyright © 2010 by the Congress of Neurological Surgeons.
EMTREE DRUG INDEX TERMS
  gelfoam; hemostatic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spine surgery; surgical approach; transoral transpharyngeal approach; 
EMTREE MEDICAL INDEX TERMS
  artery injury (complication); brain stem; cervical spine; computer assisted tomography; cranial nerve; dens axis resection; dysphagia; endoscopic surgery; face deformity (surgery); gold standard; human; liquorrhea (complication); maxilla osteotomy; nasopharynx tumor (surgery); nerve function; palatopharyngeal incompetence (complication); patient positioning; perioperative period; postoperative hemorrhage (complication, drug therapy); preoperative care; priority journal; review; rheumatoid arthritis; surgical anatomy; surgical technique; tracheostomy; vertebral artery; 
DRUG MANUFACTURERS
   (United States)Baxter
   (United States)Pfizer
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010141857
MEDLINE PMID
  20173513 (http://www.ncbi.nlm.nih.gov/pubmed/20173513)
PUI
  L358378826
DOI
  10.1227/01.NEU.0000365748.00721.0B
FULL TEXT LINK
  http://dx.doi.org/10.1227/01.NEU.0000365748.00721.0B
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0148396X&id=doi:10.1227%2F01.NEU.0000365748.00721.0B&atitle=Transoral+approaches+to+the+cervical+spine&stitle=Neurosurgery&title=Neurosurgery&volume=66&issue=SUPPL.+3&spage=&epage=&aulast=Hsu&aufirst=Wesley&auinit=W.&aufull=Hsu+W.&coden=NRSRD&isbn=&pages=-&date=2010&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 738
TITLE
  Penetrating neck trauma causing tracheal rupture, spinal cord injury, and 
massive pneumocephalus
AUTHOR NAMES
  Archan S.; Gumpert R.
AUTHOR ADDRESSES
  (Archan S., sylvia.archan@medunigraz.at) Department of Anesthesiology and 
Critical Care, Medical University of Graz, 8036 Graz, Austria.
(Gumpert R.) Department of Trauma Surgery, Medical University of Graz, 8036 
Graz, Austria.
CORRESPONDENCE ADDRESS
  S. Archan, Department of Anesthesiology and Critical Care, Medical 
University of Graz, 8036 Graz, Austria. Email: sylvia.archan@medunigraz.at
AiP/IP ENTRY DATE
  2010-02-17
FULL RECORD ENTRY DATE
  2010-03-12
SOURCE
  American Journal of Emergency Medicine (2010) 28:2 (254.e1-254.e2). Date of 
Publication: February 2010
VOLUME
  28
ISSUE
  2
DATE OF PUBLICATION
  February 2010
ISSN
  0735-6757
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
EMTREE DRUG INDEX TERMS
  metal; suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neck injury; penetrating trauma; pneumocephalus (diagnosis, etiology); spinal cord injury; trachea injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; atelectasis (diagnosis); bleeding; case report; cervical spine; computer assisted tomography; cyanosis; diagnostic error; disease association; dyspnea; emergency physician; esophagus injury; fluid resuscitation; Glasgow coma scale; hematopneumothorax; hemorrhagic shock; human; injury severity; intubation; lung contusion; male; motor performance; multiple trauma; occupational accident; oxygenation; pathophysiology; pneumomediastinum; priority journal; spine fracture; spine scintiscanning; thorax radiography; thyroid gland; tracheoesophageal fistula (complication); tracheotomy; 
CAS REGISTRY NUMBERS
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2010099262
MEDLINE PMID
  20159405 (http://www.ncbi.nlm.nih.gov/pubmed/20159405)
PUI
  L358266216
DOI
  10.1016/j.ajem.2009.05.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ajem.2009.05.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07356757&id=doi:10.1016%2Fj.ajem.2009.05.004&atitle=Penetrating+neck+trauma+causing+tracheal+rupture%2C+spinal+cord+injury%2C+and+massive+pneumocephalus&stitle=Am.+J.+Emerg.+Med.&title=American+Journal+of+Emergency+Medicine&volume=28&issue=2&spage=&epage=&aulast=Archan&aufirst=Sylvia&auinit=S.&aufull=Archan+S.&coden=AJEME&isbn=&pages=-&date=2010&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 739
TITLE
  Mechanical insufflation exsufflation: Practice patterns among respiratory 
therapists in ontario
ORIGINAL (NON-ENGLISH) TITLE
  Insufflation et exsufflation mécaniques: Modèles de pratique chez les 
thérapeutes respiratoires en Ontario
AUTHOR NAMES
  Prevost S.; Brooks D.; Bedard M.; Bwititi P.
AUTHOR ADDRESSES
  (Prevost S.) St. Joseph's Care Group, Thunder Bay Regional Health Sciences 
Center, Canada.
(Brooks D.) University of Toronto, Canada.
(Bedard M.) Lakehead University, Canada.
(Bwititi P.) Charles Sturt University, Australia.
CORRESPONDENCE ADDRESS
  S. Prevost, St. Joseph's Care Group, Thunder Bay Regional Health Sciences 
Center, Canada.
FULL RECORD ENTRY DATE
  2012-08-14
SOURCE
  Canadian Journal of Respiratory Therapy (2010) 46:2 (50-51+54-55). Date of 
Publication: Summer 2010
VOLUME
  46
ISSUE
  2
FIRST PAGE
  50
LAST PAGE
  51+54-55
DATE OF PUBLICATION
  Summer 2010
CONFERENCE NAME
  CSSRT Education Conference and Trade Show 2010
CONFERENCE LOCATION
  St. John's, NL, Canada
CONFERENCE DATE
  2010-05-13 to 2010-05-13
ISSN
  1205-9838
BOOK PUBLISHER
  Canadian Society of Respiratory Therapists
ABSTRACT
  INTRODUCTION: The mechanical insufflator exsufflator (MIE) is effective in 
assisting cough and in helping to avoid unplanned hospitalizations, 
tracheostomy and long-term ventilation in patients with neuromuscular 
disease or spinal cord injury. In spite of this, the availability and usage 
of the device in Canada is not known. OBJECTIVE To investigate practice 
patterns and availability of the MIE in Ontario hospitals. METHODS: A 
cross-sectional, self-administered mail survey was sent to a random sample 
of 400 respiratory therapists practicing within 96 Ontario hospitals. 
RESULTS: A total of 114 (28%) completed surveys were returned from 62 (65%) 
hospitals. Twenty hospitals (32%) had a MIE. Predominantly the respiratory 
therapist was the health care provider using the MIE. The device was most 
commonly used in the intensive care unit and medical/surgical units in 
patients with neuromuscular diseases or spinal cord injuries. Optimal 
pressure spans of 35 cmH2O to 40 cmH2O were used by 54% of respondents. 
Fourteen of the 20 hospitals with a MIE had policies or guidelines in place 
and 4 of those hospitals had established staff competencies. Measurements of 
peak cough flow, maximal inspiratory/expiratory pressure and vital capacity 
were reported to be infrequently performed. CONCLUSIONS: This study 
demonstrated the MIE device is not widely available in Ontario hospitals and 
there are variations in how the devices are applied possibly resulting in 
suboptimal therapy. A comprehensive educational program on MIE devices that 
incorporates best practices and a practical component is recommended for 
current providers as well as for inclusion in student curriculum.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aeration; Canada; education; human; respiratory therapist; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; coughing; curriculum; devices; forced expiratory volume; health care personnel; hospital; hospitalization; intensive care unit; neuromuscular disease; patient; policy; random sample; spinal cord injury; student; therapy; tracheostomy; vital capacity; 
LANGUAGE OF ARTICLE
  French, English
LANGUAGE OF SUMMARY
  English, French
PUI
  L70828709
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=12059838&id=doi:&atitle=Mechanical+insufflation+exsufflation%3A+Practice+patterns+among+respiratory+therapists+in+ontario&stitle=Can.+J.+Resp.+Ther.&title=Canadian+Journal+of+Respiratory+Therapy&volume=46&issue=2&spage=50&epage=51%2B54-55&aulast=Prevost&aufirst=Shelley&auinit=S.&aufull=Prevost+S.&coden=&isbn=&pages=50-51%2B54-55&date=2010&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 740
TITLE
  Up the spinal canal without a paddle: Consideration of neurology's role in 
spinal cord injury
AUTHOR NAMES
  Tansey K.
AUTHOR ADDRESSES
  (Tansey K., keith_tansey@shepherd.org) Spinal Cord Injury Research, Crawford 
Research Institute, Shepherd Center, United States.
(Tansey K., keith_tansey@shepherd.org) Departments of Neurology and 
Physiology, Emory University, 2020 Peachtree Rd NW, Atlanta, GA 30309, 
United States.
CORRESPONDENCE ADDRESS
  K. Tansey, Departments of Neurology and Physiology, Emory University, 2020 
Peachtree Rd NW, Atlanta, GA 30309, United States. Email: 
keith_tansey@shepherd.org
AiP/IP ENTRY DATE
  2010-10-04
FULL RECORD ENTRY DATE
  2010-10-08
SOURCE
  Archives of Neurology (2010) 67:9 (1053-1054). Date of Publication: 
September 2010
VOLUME
  67
ISSUE
  9
FIRST PAGE
  1053
LAST PAGE
  1054
DATE OF PUBLICATION
  September 2010
ISSN
  1538-3687 (electronic)
  0003-9942
BOOK PUBLISHER
  American Medical Association, smcleod@itsa.ucsf.edu
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord disease (diagnosis); spinal cord injury (diagnosis); vertebral canal; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; autonomic dysfunction; autonomic dysreflexia; bladder training; cancer rehabilitation; cerebrospinal fluid analysis; cerebrovascular accident (diagnosis); certification; constipation; curriculum; deep vein thrombosis; diagnostic error; diaphragm; editorial; follow up; Guillain Barre syndrome (diagnosis); human; intensive care unit; Internet; lung embolism; medical education; medical student; nerve cell plasticity; neurologic disease; neuropathic pain; neurosurgery; pathophysiology; patient education; physical medicine; practice guideline; priority journal; quality of life; reimbursement; resident; sedation; spasticity; specialization; spine stabilization; tracheostomy; treatment outcome; urinary tract infection; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2010527624
MEDLINE PMID
  20837846 (http://www.ncbi.nlm.nih.gov/pubmed/20837846)
PUI
  L359633564
DOI
  10.1001/archneurol.2010.202
FULL TEXT LINK
  http://dx.doi.org/10.1001/archneurol.2010.202
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15383687&id=doi:10.1001%2Farchneurol.2010.202&atitle=Up+the+spinal+canal+without+a+paddle%3A+Consideration+of+neurology%27s+role+in+spinal+cord+injury&stitle=Arch.+Neurol.&title=Archives+of+Neurology&volume=67&issue=9&spage=1053&epage=1054&aulast=Tansey&aufirst=Keith&auinit=K.&aufull=Tansey+K.&coden=ARNEA&isbn=&pages=1053-1054&date=2010&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 741
TITLE
  Paraneoplastic jaw dystonia and laryngospasm with antineuronal nuclear 
autoantibody type 2 (anti-Ri)
AUTHOR NAMES
  Pittock S.J.; Parisi J.E.; McKeon A.; Roemer S.F.; Lucchinetti C.F.; Tan K.M.; Keegan B.M.; Hunter S.F.; Duncan P.R.; Baehring J.M.; Matsumoto J.Y.; Lennon V.A.
AUTHOR ADDRESSES
  (Pittock S.J., pittock.sean@mayo.edu; McKeon A.; Roemer S.F.; Lucchinetti 
C.F.; Tan K.M.; Keegan B.M.; Matsumoto J.Y.; Lennon V.A.) Department of 
Neurology, Mayo Medical School College of Medicine, Mayo Clinic, Rochester, 
MN, United States.
(Pittock S.J., pittock.sean@mayo.edu; Parisi J.E.; McKeon A.; Tan K.M.; 
Lennon V.A.) Department of Laboratory Medicine and Pathology, Mayo Medical 
School College of Medicine, Mayo Clinic, Rochester, MN, United States.
(Lennon V.A.) Department of Immunology, Mayo Medical School College of 
Medicine, Mayo Clinic, Rochester, MN, United States.
(Pittock S.J., pittock.sean@mayo.edu; McKeon A.; Lennon V.A.) 
Neuroimmunology Laboratory, Mayo Medical School College of Medicine, Mayo 
Clinic, 200 First St SW, Rochester, MN 55905, United States.
(Hunter S.F.) Advanced Neurosciences Institute, Franklin, TN, United States.
(Duncan P.R.) Hematology Oncology Associates, Albuquerque, NM, United 
States.
(Baehring J.M.) Department of Neurosurgery, Yale University School of 
Medicine, New Haven, CT, United States.
CORRESPONDENCE ADDRESS
  S. J. Pittock, Neuroimmunology Laboratory, Mayo Medical School College of 
Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. 
Email: pittock.sean@mayo.edu
AiP/IP ENTRY DATE
  2010-10-04
FULL RECORD ENTRY DATE
  2010-10-11
SOURCE
  Archives of Neurology (2010) 67:9 (1109-1115). Date of Publication: 
September 2010
VOLUME
  67
ISSUE
  9
FIRST PAGE
  1109
LAST PAGE
  1115
DATE OF PUBLICATION
  September 2010
ISSN
  1538-3687 (electronic)
  0003-9942
BOOK PUBLISHER
  American Medical Association, smcleod@itsa.ucsf.edu
ABSTRACT
  Background: Opsoclonus-myoclonus syndrome and breast carcinoma were 
initially described as neurologic and oncologic accompaniments of 
antineuronal nuclear autoantibody type 2 (ANNA-2, also known as anti-Ri). 
However, the neurologic spectrum of ANNA-2 autoimmunity is broader, includes 
a syndrome of jaw dystonia and laryngospasm, and can be accompanied by lung 
carcinoma. Objective: To describe clinically (with a video) 
ANNA-2-associated jaw dystonia and laryngospasm, its pathologic correlates, 
and therapeutic outcomes. Design: Retrospective case series with prospective 
clinical follow-up. Setting: Mayo Clinic's Neuroimmunology Laboratory, 
Rochester, Minnesota. Patients: Consecutive patients with ANNA-2 
seropositivity identified since January 1, 1990. Main OutcomeMethods: 
Clinical (in 9 patients) and neuropathologic (in 2 patients) findings were 
reviewed. Results: Of 48 patients with ANNA-2 seropositivity, 9 (19%) had 
multifocal neurologic manifestations that included jaw dystonia and 
laryngospasm. Among 6 patients with jaw dystonia, 5 had severely impaired 
nutrition, causing profound weight loss. Five patients had documented 
laryngospasm, which contributed to 1 patient's death. Neuropathologic 
examination revealed diffuse infiltration by CD8(+) T lymphocytes, with 
axonal loss and gliosis in brain-stem and descending spinal cord tracts. 
Some patients improved symptomatically after immunosuppressant or cytotoxic 
therapies; 1 patient improved after treatment with botulinum toxin. One 
patient who underwent tracheostomy because of recurrent laryngospasm was 
alive and well longer than 3 years after symptom onset. Conclusions: Jaw 
dystonia and laryngospasm are common accompaniments of ANNA-2 autoimmunity 
and are associated with significant morbidity. We propose that selective 
damage to antigen-containing inhibitory fibers innervating bulbar motor 
nuclei by CD8 (+) T lymphocytes (histopathologically observed infiltrating 
brain-stem reticular formation) is the proximal cause of this syndrome. 
Early and aggressive therapy offers the prospect of neurologic improvement 
or stabilization. ©2010 American Medical Association. All rights reserved.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  antineuronal nuclear autoantibody type 2 (endogenous compound); antinuclear antibody (endogenous compound); 
EMTREE DRUG INDEX TERMS
  amitriptyline (drug combination, drug therapy); baclofen (drug combination, drug therapy); botulinum toxin (drug therapy); clonazepam (drug combination, drug therapy); cyclophosphamide (drug combination, drug therapy, oral drug administration); dexamethasone (drug therapy, oral drug administration); doxorubicin (drug combination, drug therapy); immunoglobulin (drug therapy, intravenous drug administration); lorazepam (drug therapy); methylprednisolone (drug therapy, intravenous drug administration); paclitaxel (drug therapy); prednisone (drug dose, drug therapy); tamoxifen citrate (drug combination, drug therapy); temazepam (drug therapy); trihexyphenidyl (drug therapy); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dystonia (drug therapy, drug therapy); jaw disease (drug therapy, drug therapy); larynx spasm (drug therapy, drug therapy); paraneoplastic jaw dystonia (drug therapy, drug therapy); paraneoplastic syndrome (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; body weight loss; brain stem; case study; CD8+ T lymphocyte; clinical article; disease association; disease severity; drug megadose; female; follow up; gliosis; histopathology; human; immunosuppressive treatment; male; malnutrition; medical record review; mortality; neuropathology; outcome assessment; priority journal; prospective study; recurrent disease; retrospective study; spinal cord; tracheostomy; treatment response; United States; 
CAS REGISTRY NUMBERS
  amitriptyline (50-48-6, 549-18-8)
  baclofen (1134-47-0)
  clonazepam (1622-61-3)
  cyclophosphamide (50-18-0)
  dexamethasone (50-02-2)
  doxorubicin (23214-92-8, 25316-40-9)
  immunoglobulin (9007-83-4)
  lorazepam (846-49-1)
  methylprednisolone (6923-42-8, 83-43-2)
  paclitaxel (33069-62-4)
  prednisone (53-03-2)
  tamoxifen citrate (54965-24-1)
  temazepam (846-50-4)
  trihexyphenidyl (144-11-6, 52-49-3)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Drug Literature Index (37)
  General Pathology and Pathological Anatomy (5)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010527634
MEDLINE PMID
  20837856 (http://www.ncbi.nlm.nih.gov/pubmed/20837856)
PUI
  L359633574
DOI
  10.1001/archneurol.2010.209
FULL TEXT LINK
  http://dx.doi.org/10.1001/archneurol.2010.209
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15383687&id=doi:10.1001%2Farchneurol.2010.209&atitle=Paraneoplastic+jaw+dystonia+and+laryngospasm+with+antineuronal+nuclear+autoantibody+type+2+%28anti-Ri%29&stitle=Arch.+Neurol.&title=Archives+of+Neurology&volume=67&issue=9&spage=1109&epage=1115&aulast=Pittock&aufirst=Sean+J.&auinit=S.J.&aufull=Pittock+S.J.&coden=ARNEA&isbn=&pages=1109-1115&date=2010&auinit1=S&auinitm=J
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 742
TITLE
  Temporary tracheostomy required as an infant may be a risk factor for future 
centrally mediated disordered sleep ventilation
AUTHOR NAMES
  Adderley R.; Wensley D.
AUTHOR ADDRESSES
  (Adderley R., radderley@cw.bc.ca; Wensley D.) Critical Care Services, 
University of British Columbia, British Columbia's Children's Hospital, 4480 
Oak Street, Vancouver, Canada.
CORRESPONDENCE ADDRESS
  R. Adderley, Critical Care Services, University of British Columbia, British 
Columbia's Children's Hospital, 4480 Oak Street, Vancouver, Canada. Email: 
radderley@cw.bc.ca
FULL RECORD ENTRY DATE
  2011-01-29
SOURCE
  Cerebrospinal Fluid Research (2010) 7 SUPPL. 1. Date of Publication: 2010
VOLUME
  7
DATE OF PUBLICATION
  2010
CONFERENCE NAME
  54th Annual Meeting of the Society for Research into Hydrocephalus and Spina 
Bifida
CONFERENCE LOCATION
  Vancouver, BC, Canada
CONFERENCE DATE
  2010-07-07 to 2010-07-10
ISSN
  1743-8454
BOOK PUBLISHER
  BioMed Central Ltd.
ABSTRACT
  Background: Children with spina bifida experience lifelong complex medical 
issues. The problems of locomotion, and neurogenic bowel and bladder are 
well appreciated, and the necessity of shunting obstructive hydrocephalus is 
equally well known. There are however, serious, less common problems 
associated with control of ventilation. Most common is vocal cord 
dysfunction, with unilateral or bilateral vocal cord paresis, and as a 
consequence, upper airway obstruction. Rarer still, are patients with life 
threatening breath holding spells, central apnea, or mixed central and 
obstructive apnea. In many cases, surgical decompression of the posterior 
fossa can result in return of vocal cord function, and relief of obstructive 
apnea. In a few cases tracheostomy is required. With a Chairi II 
malformation, the upper medulla, where the nuclei of cranial nerves IX and X 
lie close to the rostral tracts of the respiratory centre, may have an 
abnormal and tenuous blood supply. The medulla may be compromised by bony 
pressure or by compromise of the blood supply (herniation or chronic 
arachnoiditis). Materials and methods: The Spinal Cord Program at British 
Columbia's Children's Hospital has cared for 956 patients since 1982. Over 
the same period, the Home Tracheostomy Care/ Home Ventilation Program has 
cared for 346 children, eight with spinal dysrhaphism. Two girls with 
meningomyelocoele and Arnold Chiari type II malformations, who had required 
tracheostomies as infants, presented as adolescents with symptoms suggestive 
of disordered sleep ventilation. Both had required a tracheostomy despite 
timely posterior fossa decompression, but over time (years), gag and vocal 
cord function returned, and they were successfully decannulated. Patient 1, 
with a lumbosacral meningomyelocoele was referred to the Home Ventilation 
Program at fourteen years of age when her mother, a registered nurse 
reported erratic breathing at night, with weight loss, and deteriorating 
school performance. Patient 2, with a lumber meningomyelocoele presented at 
fifteen years of age complaining of daytime somnolence, but denied morning 
headaches. In both cases polysomnography showed a similar, chaotic pattern 
of respiration with frequent arousals and severely fragmented sleep. 
Computerized Tomography showed no change in ventricular size in either case. 
Results: Both patients were started on nighttime noninvasive ventilation 
(NIPPV) with rapid resolution of symptoms. Conclusions: Children with 
meningomyelocoele, particularly those who appear to have had resolution of 
infantile bulbar dysfunction, may present later in life with severely 
disordered sleep ventilation, and warrant careful lifelong followup, with a 
low threshold for polysomnography and institution of ventilatory support.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  air conditioning; hydrocephalus; infant; risk factor; sleep; society; spinal dysraphism; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  academic achievement; adolescent; apnea; arachnoiditis; arousal; bladder; body weight loss; breath holding; breathing; bulbar paralysis; Canada; child; computer assisted tomography; congenital malformation; cranial nerve; daytime somnolence; decompression; decompression surgery; follow up; girl; headache; hernia; locomotion; mother; neurogenic bowel; night; patient; pediatric hospital; polysomnography; posterior fossa; registered nurse; shunting; spinal cord; upper respiratory tract obstruction; vascularization; vocal cord; vocal cord paralysis; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70330709
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17438454&id=doi:&atitle=Temporary+tracheostomy+required+as+an+infant+may+be+a+risk+factor+for+future+centrally+mediated+disordered+sleep+ventilation&stitle=Cerebrospinal+Fluid+Res.&title=Cerebrospinal+Fluid+Research&volume=7&issue=&spage=&epage=&aulast=Adderley&aufirst=Robert&auinit=R.&aufull=Adderley+R.&coden=&isbn=&pages=-&date=2010&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 743
TITLE
  Airway management in acute tetraplegics: A retrospective study
AUTHOR NAMES
  Seidl R.O.; Wolf D.; Nusser-Müller-Busch R.; Niedeggen A.
AUTHOR ADDRESSES
  (Seidl R.O., ROSeidl@ukb.de; Wolf D.) Department of Otolaryngology, 
Unfallkrankenhaus Berlin, Warener Strae 7, Berlin 12683, Germany.
(Nusser-Müller-Busch R.) Department of Speech and Language Therapy, 
Unfallkrankenhaus Berlin, Berlin, Germany.
(Niedeggen A.) Spinal Cord Injury Center, Unfallkrankenhaus Berlin, Berlin, 
Germany.
CORRESPONDENCE ADDRESS
  R. O. Seidl, Department of Otolaryngology, Unfallkrankenhaus Berlin, Warener 
Strae 7, Berlin 12683, Germany. Email: ROSeidl@ukb.de
AiP/IP ENTRY DATE
  2010-03-08
FULL RECORD ENTRY DATE
  2010-07-28
SOURCE
  European Spine Journal (2010) 19:7 (1073-1078). Date of Publication: July 
2010
VOLUME
  19
ISSUE
  7
FIRST PAGE
  1073
LAST PAGE
  1078
DATE OF PUBLICATION
  July 2010
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  The objective of this study was to develop an evidence-based airway 
management protocol for patients with acute tetraplegia. The method 
consisted of an analysis of the medical records of patients (September 
1997-December 2002) with a spinal cord injury and a neurological deficit 
less than 8 weeks old. Of the 175 patients, 72 (41, 14%) were 
tracheotomised. This was influenced by the origin of the paralysis, Frankel 
score, and number of cervical spine operations, accompanying injuries and 
accompanying illnesses. Tracheotomy did not affect the duration of 
treatment, duration of ventilation or length of stay in the intensive care 
unit. The need for a tracheotomy was able to be predicted in 73.31% with 
neurological level, Frankel score and severity of accompanying injuries. In 
patients with acute tetraplegia, primary tracheotomy is indicated in sub 
C1-C3 with Frankel stage A/B, sub C4-C6 with Frankel stage A/B with trauma 
and accompanying injuries/accompanying illnesses, and in patients with 
complex cervical spine trauma that requires a combined surgical approach. In 
other patients, an attempt at extubation should be made. © 2010 
Springer-Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia (surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; airway conductance; article; artificial ventilation; cervical spine injury; disease severity; female; human; intensive care; intubation; length of stay; major clinical study; male; medical record; neurologic disease; priority journal; rating scale; spinal cord injury; tracheotomy; treatment duration; treatment outcome; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010383275
MEDLINE PMID
  20179975 (http://www.ncbi.nlm.nih.gov/pubmed/20179975)
PUI
  L50817881
DOI
  10.1007/s00586-010-1328-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-010-1328-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-010-1328-7&atitle=Airway+management+in+acute+tetraplegics%3A+A+retrospective+study&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=19&issue=7&spage=1073&epage=1078&aulast=Seidl&aufirst=Rainer+O.&auinit=R.O.&aufull=Seidl+R.O.&coden=ESJOE&isbn=&pages=1073-1078&date=2010&auinit1=R&auinitm=O
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 744
TITLE
  Efficacy of spinal needle aspiration for epiglottic abscess in 90 patients 
with acute epiglottitis
AUTHOR NAMES
  Kim S.G.; Lee J.H.; Park D.J.; Hong J.W.; Kim T.H.; Kim M.G.; Shim J.S.; Yeo S.G.
AUTHOR ADDRESSES
  (Kim S.G.; Lee J.H.; Park D.J.; Hong J.W.; Kim T.H.; Kim M.G.) Department of 
Otorhinolaryngology-Head and Neck Surgery, Masan Samsung Medical Center, 
Sungkyunkwan University, Masan, South Korea.
(Shim J.S.; Yeo S.G., yeo2park@yahoo.co.kr) Department of 
Otorhinolaryngology-Head and Neck Surgery, College of Medicine, KyungHee 
University, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  S. G. Yeo, #1 Hoegi-dong, dongdaemun-gu, Seoul, South Korea. Email: 
yeo2park@yahoo.co.kr
FULL RECORD ENTRY DATE
  2009-12-30
SOURCE
  Acta Oto-Laryngologica (2009) 129:7 (760-767). Date of Publication: 2009
VOLUME
  129
ISSUE
  7
FIRST PAGE
  760
LAST PAGE
  767
DATE OF PUBLICATION
  2009
ISSN
  0001-6489
  1651-2553 (electronic)
BOOK PUBLISHER
  Informa Healthcare, Telephone House, 69 - 77 Paul Street, United Kingdom.
ABSTRACT
  Conclusion. Patients with epiglottic abscesses showed more severe symptoms 
than those with acute epiglottitis and were at increased risk of airway 
compromise. All 11 patients with epiglottic abscesses underwent spinal 
needle aspiration;all were cured without severe complications. These 
findings indicate that spinal needle aspiration is both safe and effective 
in patients with epiglottic abscesses. Objectives. Acute epiglottitis is a 
disease that may become serious or even fatal because of sudden upper airway 
obstruction. An epiglottic abscess may result from a coalescent epiglottic 
infection due to acute epiglottitis or secondary infection of an epiglottic 
mucocele. There have been few reports comparing acute epiglottitis with 
epiglottic abscess. We therefore assessed the clinical characteristics of 
each condition, as well as the efficacy of spinal needle aspiration and 
drainage of epiglottic abscesses. Patients and methods. We retrospectively 
reviewed the records of 90 hospitalized patients diagnosed with acute 
epiglottitis and epiglottic abscess by flexible nasopharyngolaryngoscopy 
between March 2006 and February 2008. All patients were treated with 
medication;in addition, those with epiglottic abscess underwent spinal 
needle aspiration. Results. Of 90 patients, 79 had acute epiglottitis and 11 
had epiglottic abscesses. Acute epiglottitis was most common in May (16.5%) 
and epiglottic abscesses were most common in June (27.3%). The most common 
symptoms were sore throat (91.1%), dysphagia (38.9%), voice change (33.3%), 
and dyspnea (16.7%). All patients were treated with antibiotics and 
steroids. The mean length of hospitalization was 5 days. No patient required 
a tracheostomy or orotracheal intubation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abscess drainage; acute epiglottitis (surgery); fine needle aspiration biopsy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; child; dysphagia; dyspnea; female; hospitalization; human; major clinical study; male; priority journal; retrospective study; sore throat; voice change; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009638707
MEDLINE PMID
  18728917 (http://www.ncbi.nlm.nih.gov/pubmed/18728917)
PUI
  L355779521
DOI
  10.1080/00016480802369302
FULL TEXT LINK
  http://dx.doi.org/10.1080/00016480802369302
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016489&id=doi:10.1080%2F00016480802369302&atitle=Efficacy+of+spinal+needle+aspiration+for+epiglottic+abscess+in+90+patients+with+acute+epiglottitis&stitle=Acta+Oto-Laryngol.&title=Acta+Oto-Laryngologica&volume=129&issue=7&spage=760&epage=767&aulast=Kim&aufirst=Sun+Gon&auinit=S.G.&aufull=Kim+S.G.&coden=AOLAA&isbn=&pages=760-767&date=2009&auinit1=S&auinitm=G
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 745
TITLE
  Optimizing speech production in the ventilatorassisted individual following 
cervical spinal cord injury a preliminary investigation
AUTHOR NAMES
  MacBean N.; Ward E.; Murdoch B.; Cahill L.; Solley M.; Geraghty T.; Hukins C.
AUTHOR ADDRESSES
  (MacBean N., naomi@hartleys.id.au; Ward E.; Murdoch B.; Cahill L.) Division 
of Speech Pathology, School of Health and Rehabilitation Sciences, 
University of Queensland, Brisbane, QLD, Australia.
(Solley M.) Department of Speech Pathology, Princess Alexandra Hospital, 
Brisbane, QLD, Australia.
(Geraghty T.) Spinal Injuries Unit, Queensland Spinal Cord Injuries 
Services, Princess Alexandra Hospital, Brisbane, QLD, Australia.
(Hukins C.) Sleep Disorders Centre, Princess Alexandra Hospital, Brisbane, 
QLD, Australia.
CORRESPONDENCE ADDRESS
  N. MacBean, PO Box 1466, Kenmore, QLD 4069, Australia. Email: 
naomi@hartleys.id.au
FULL RECORD ENTRY DATE
  2009-12-07
SOURCE
  International Journal of Language and Communication Disorders (2009) 44:3 
(382-393). Date of Publication: 2009
VOLUME
  44
ISSUE
  3
FIRST PAGE
  382
LAST PAGE
  393
DATE OF PUBLICATION
  2009
ISSN
  1368-2822
  1460-6984 (electronic)
BOOK PUBLISHER
  Informa Healthcare, Telephone House, 69 - 77 Paul Street, United Kingdom.
ABSTRACT
  Background: Mechanical ventilation is commonly used during the acute 
management of cervical spinal cord injury, and is required on an ongoing 
basis in the majority of patients with injuries at or above C3. However, to 
date there have been limited systematic investigations of the options 
available to improve speech while ventilatorassisted postcervical spinal 
cord injury. Aims: To provide preliminary evidence of any benefits gained 
through the addition of positive end expiratory pressure PEEP andor a 
tracheostomy speech valve to the condition of leak speech. Methods & 
Procedures: Speech production in the three conditions was compared in two 
ventilatorassisted participants using a series of instrumental and 
perceptual speech measures. Outcomes & Results The addition of PEEP or the 
use of a speech valve resulted in speech that was superior to leak speech 
for both participants however, individual variation was present. Conclusions 
& Implications: Leak speech alone or with the addition of PEEP or a 
tracheostomy speech valve can facilitate functional communication for the 
ventilated patient, though PEEP and valve speech were found to be superior 
in the current study. These findings will be of assistance for clinicians 
counselling the growing population of patients who may require tracheostomy 
positive pressure ventilation longterm regarding communication options.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; speech; 
EMTREE MEDICAL INDEX TERMS
  adult; article; clinical article; controlled study; human; interpersonal communication; male; positive end expiratory pressure; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009572610
MEDLINE PMID
  18821115 (http://www.ncbi.nlm.nih.gov/pubmed/18821115)
PUI
  L355545846
DOI
  10.1080/13682820802190339
FULL TEXT LINK
  http://dx.doi.org/10.1080/13682820802190339
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13682822&id=doi:10.1080%2F13682820802190339&atitle=Optimizing+speech+production+in+the+ventilatorassisted+individual+following+cervical+spinal+cord+injury+a+preliminary+investigation&stitle=Int.+J.+Lang.+Commun.+Disord.&title=International+Journal+of+Language+and+Communication+Disorders&volume=44&issue=3&spage=382&epage=393&aulast=MacBean&aufirst=Naomi&auinit=N.&aufull=MacBean+N.&coden=IJLDF&isbn=&pages=382-393&date=2009&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 746
TITLE
  Editorial: Spinal muscular atrophy: The challenges of 'doing the right 
thing'
AUTHOR NAMES
  Wilton N.C.T.
AUTHOR ADDRESSES
  (Wilton N.C.T., niallw@adhb.govt.nz) Paediatric Anaesthesia and Operating 
Rooms, Starship Children's Hospital, Auckland, New Zealand.
CORRESPONDENCE ADDRESS
  N. C. T. Wilton, Paediatric Anaesthesia and Operating Rooms, Starship 
Children's Hospital, Auckland, New Zealand. Email: niallw@adhb.govt.nz
FULL RECORD ENTRY DATE
  2009-12-07
SOURCE
  Paediatric Anaesthesia (2009) 19:11 (1041-1047). Date of Publication: 2009
VOLUME
  19
ISSUE
  11
FIRST PAGE
  1041
LAST PAGE
  1047
DATE OF PUBLICATION
  2009
ISSN
  1155-5645
  1460-9592 (electronic)
BOOK PUBLISHER
  Blackwell Publishing Ltd, 9600 Garsington Road, Oxford, United Kingdom.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); survival motor neuron protein 1 (endogenous compound); survival motor neuron protein 2 (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy (etiology); 
EMTREE MEDICAL INDEX TERMS
  aeration; antibiotic therapy; artificial ventilation; assisted ventilation; atelectasis; breathing disorder; bulbar paralysis; disease course; disease severity; Duchenne muscular dystrophy; dysphagia; editorial; feeding tube; forced expiratory volume; gastroesophageal reflux; gene disruption; gene expression; human; Kugelberg Welander disease; lifespan; lung edema (complication); lung function test; morbidity; motoneuron; motor dysfunction; neuromuscular disease; physiotherapy; pneumonia (drug therapy); positive end expiratory pressure; postoperative analgesia; priority journal; quality of life; recurrent infection (drug therapy); reflex; reflex disorder; respiratory failure; respiratory function; spirometry; stomach fundoplication; stomach tube; sucking reflex; survival rate; tooth disease (complication); tracheostomy; walking difficulty; Werdnig Hoffmann disease; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2009568820
MEDLINE PMID
  19807884 (http://www.ncbi.nlm.nih.gov/pubmed/19807884)
PUI
  L355530886
DOI
  10.1111/j.1460-9592.2009.03135.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1460-9592.2009.03135.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11555645&id=doi:10.1111%2Fj.1460-9592.2009.03135.x&atitle=Editorial%3A+Spinal+muscular+atrophy%3A+The+challenges+of+%27doing+the+right+thing%27&stitle=Paediatr.+Anaesth.&title=Paediatric+Anaesthesia&volume=19&issue=11&spage=1041&epage=1047&aulast=Wilton&aufirst=Niall+C.+T.&auinit=N.C.T.&aufull=Wilton+N.C.T.&coden=PAANF&isbn=&pages=1041-1047&date=2009&auinit1=N&auinitm=C.T.
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 747
TITLE
  Life threatening complications after unsuccessful attempt of the guidewire 
dilating forceps tracheostomy in multi-trauma patient with cervical spine 
injury.
AUTHOR NAMES
  Bartolek D.; Somun N.; Bartolek F.; Zdravcević-Sakić K.; Lajtman Z.; Banić T.; Cavrić G.; Kovabić-Vicić V.
AUTHOR ADDRESSES
  (Bartolek D.; Somun N.; Bartolek F.; Zdravcević-Sakić K.; Lajtman Z.; Banić 
T.; Cavrić G.; Kovabić-Vicić V.) Department of Anesthesiology and Intensive 
Care Unit, University Clinic of Traumatology, Zagreb, Croatia.
CORRESPONDENCE ADDRESS
  D. Bartolek, Department of Anesthesiology and Intensive Care Unit, 
University Clinic of Traumatology, Zagreb, Croatia. Email: 
dubravka.bartolek1@zg.t-com.hr
FULL RECORD ENTRY DATE
  2010-03-24
SOURCE
  Collegium antropologicum (2009) 33:4 (1409-1413). Date of Publication: Dec 
2009
VOLUME
  33
ISSUE
  4
FIRST PAGE
  1409
LAST PAGE
  1413
DATE OF PUBLICATION
  Dec 2009
ISSN
  0350-6134
ABSTRACT
  Percutaneous tracheostomy (PCT) is a safe method under proper patient 
selection, increased technical experience and bronchoscopy- or 
ultrasound-guided procedure. Trauma patients with cervical spine fractures 
and spinal cord injury are at a high risk for respiratory failure and 
require a definitive airway followed by prolonged mechanical ventilation. We 
would like to present multiple, life- threatening complications after 
unsuccessful attempt of the guidewire dilating forceps tracheostomy (GWDF) 
in one trauma patient with a cervical spine injury. With this case report we 
would like to lay emphasis on the importance of continuously bronchoscopy- 
or ultrasound-guided PTC in trauma patients, especially with cervical spine 
injury, as the need to respect the steep-learning curve in its performance.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus perforation (etiology); pneumomediastinum (etiology); pneumothorax (etiology); trachea; tracheostomy (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS
  aged; article; bronchoscopy; case report; cervical spine; devices; human; injury; male; minimally invasive surgery; multiple trauma (therapy); spine fracture (therapy); 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  20102102 (http://www.ncbi.nlm.nih.gov/pubmed/20102102)
PUI
  L358463447
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03506134&id=doi:&atitle=Life+threatening+complications+after+unsuccessful+attempt+of+the+guidewire+dilating+forceps+tracheostomy+in+multi-trauma+patient+with+cervical+spine+injury.&stitle=Coll+Antropol&title=Collegium+antropologicum&volume=33&issue=4&spage=1409&epage=1413&aulast=Bartolek&aufirst=Dubravka&auinit=D.&aufull=Bartolek+D.&coden=&isbn=&pages=1409-1413&date=2009&auinit1=D&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 748
TITLE
  Neuromodulation on cervical spinal cord combined with hyperbaric oxygen in 
comatose patients-a preliminary report
AUTHOR NAMES
  Liu J.-T.; Lee J.-K.; Tyan Y.-S.; Liu C.-Y.; Chen Y.- H.; Lin T.-B.
AUTHOR ADDRESSES
  (Liu J.-T.) Department of Neurosurgery, Chung-Shan Medical University 
Hospital, Taichung, 40201, Taiwan.
(Lee J.-K.) Department of Nuclear Medicine, Chung-Shan Medical University 
Hospital, Taichung, 40201, Taiwan.
(Tyan Y.-S.) Department of Radiology, Chung-Shan Medical University 
Hospital, Taichung, 40201, Taiwan.
(Liu C.-Y.; Lin T.-B., tblin@csmu.edu.tw) Department of Physiology, College 
of Medicine, Chung-Shan Medical University, Taichung, 40201, Taiwan.
(Liu J.-T.; Lin T.-B., tblin@csmu.edu.tw) Institute of Medicine, College of 
Medicine, Chung-Shan Medical University, Taichung, 40201, Taiwan.
(Chen Y.- H.) Graduate Institute of Integrated Medicine, College of Chinese 
Medicine, China Medical University, Taichung, 40402, Taiwan.
CORRESPONDENCE ADDRESS
  T.-B. Lin, Department of Physiology, College of Medicine, Chung-Shan Medical 
University, Taichung, 40201, Taiwan. Email: tblin@csmu.edu.tw
FULL RECORD ENTRY DATE
  2010-01-27
SOURCE
  Surgical Neurology (2009) 72:SUPPL. 2 (S28-S34). Date of Publication: 
December 2009
VOLUME
  72
ISSUE
  SUPPL. 2
DATE OF PUBLICATION
  December 2009
ISSN
  0090-3019
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Background: Because both SCS and HBO therapy have shown some promise in 
treating patients with states of reduced consciousness, we evaluated the 
combination of therapies in a prospective trial in comatose patients. 
Methods: Twelve patients who had received median nerve stimulation for 3 
months without improvement in consciousness received cSCS for 1 year 
combined with simultaneous HBO therapy for the first 3 months. Another group 
enrolled 12 patients who received median nerve stimulation only were served 
as control. Results: Six patients emerged from coma at 1 year (after 
conclusion of treatment). Glasgow Coma Scale score, SPECT imaging, and PVS 
scores (state and reaction subscores) of the 12 patients were all 
significantly increased at 1 year compared with enrollment (P < .05). 
Neither respirator nor tracheostomy was needed to assist respiration in any 
patient. Only 1 of 12 patients still needed nasogastric tube feeding at 1 
year. By contrast, control patients (without cSCS and HBO therapy) showed no 
apparent improvement. Conclusion: Increase of GCS score, cerebral blood 
perfusion, and PVS scores were observed in comatose patients treated with 
combined cSCS and HBO therapy. © 2009.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord; comatose patient; hyperbaric oxygen therapy; neuromodulation; spinal cord stimulation; 
EMTREE MEDICAL INDEX TERMS
  adult; aneurysm rupture; article; brain blood flow; brain perfusion; clinical article; clinical assessment; controlled study; electrode; electroencephalography; female; Glasgow coma scale; heart arrest; human; male; median nerve; nose feeding; occupational therapy; outcome assessment; persistent vegetative state; physiotherapy; single photon emission computed tomography; subarachnoid hemorrhage; treatment duration; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009629776
MEDLINE PMID
  19665182 (http://www.ncbi.nlm.nih.gov/pubmed/19665182)
PUI
  L50604027
DOI
  10.1016/j.surneu.2009.05.029
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.surneu.2009.05.029
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903019&id=doi:10.1016%2Fj.surneu.2009.05.029&atitle=Neuromodulation+on+cervical+spinal+cord+combined+with+hyperbaric+oxygen+in+comatose+patients-a+preliminary+report&stitle=Surg.+Neurol.&title=Surgical+Neurology&volume=72&issue=SUPPL.+2&spage=&epage=&aulast=Liu&aufirst=Jung-Tung&auinit=J.-T.&aufull=Liu+J.-T.&coden=SGNRA&isbn=&pages=-&date=2009&auinit1=J&auinitm=-T
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 749
TITLE
  Safety of percutaneous tracheostomy in trauma patients
AUTHOR NAMES
  Maldonado I.; Becker S.; Fernandez C.
AUTHOR ADDRESSES
  (Maldonado I.; Becker S.) Maimonides Medical Center, United States.
(Fernandez C.) Jersey Shore University, Medical Center, United States.
CORRESPONDENCE ADDRESS
  I. Maldonado, Maimonides Medical Center, United States.
FULL RECORD ENTRY DATE
  2010-07-13
SOURCE
  Critical Care Medicine (2009) 37:12 SUPPL. (A70). Date of Publication: 
December 2009
VOLUME
  37
ISSUE
  12
FIRST PAGE
  A70
DATE OF PUBLICATION
  December 2009
CONFERENCE NAME
  39th Critical Care Congress of the Society of Critical Care Medicine's
CONFERENCE LOCATION
  Miami Beach, FL, United States
CONFERENCE DATE
  2010-01-09 to 2010-01-13
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Percutaneous tracheostomy is a common procedure in many Trauma 
Intensive Care units. A concern about the safety of performing percutaneous 
tracheostomy in patients with no cervical spine clearance or cervical spine 
injury exists. This concern has had an impact on the consideration to 
perform percutaneous tracheostomies in this group of patients. Most experts 
recommend the use of fiberoptic bronchoscopy assistance during percutaneous 
tracheostomy. Hypothesis: Performing percutaneous tracheostomy in trauma 
patients with either no cervical spine clearance status or cervical spine 
injury status is as safe as open tracheostomy. Methods: From January 2001 to 
December 2007 we retrospectively evaluated the medical records of all 
patients with blunt trauma who required tracheostomy in a Level II Trauma 
Center. Data was gathered from a trauma registry database and medical 
records. Patients were divided in two groups. Open Tracheostomy (OT) and 
Percutaneous Tracheostomy (PT). Patient age. Injury Severity Score (ISS). 
type of tracheostomy insertion method. cervical spine clearance status prior 
to tracheostomy. presence of cervical spine injury. use of bronchoscopy 
assistance in percutaneous tracheostomy. and immediate complications post 
tracheostomy were recorded for each patient. Results: The total number of 
tracheotomies during the study period was 220 of which 125 (56%) were PT and 
95(44%) were OT. Both groups were similar in age. sex and ISS distribution. 
Of the OT group. 60 (63%) were done in patients with no cervical spine 
clearance or cervical spine injury. There were no immediate complications 
reported in the OT group. The PT group had 63 cases (50.4%) done with no 
preoperative cervical spine clearance or positive for cervical spine injury. 
The PT group underwent the procedure without bronchoscopy assistance in 95% 
of the cases. Two cases (1.5%) in the PT group were reported with 
postoperative bleeding from the tracheostomy site that did not required 
intervention. Both cases were PT done without bronchoscopy assistance and 
did not have pre-operative cervical spine clearance. No other immediate 
complications were reported in the PT group. Conclusions: The results of 
this study suggest that PT is safe in trauma patients without preoperative 
cervical spine clearance or with cervical injuries as compared with the OT 
group. Most of the PT cases were done without bronchoscopy assistance (95%). 
This finding suggests the need of further study to clarify the role of 
bronchoscopy assistance in PT.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; intensive care; patient; safety; society; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  blunt trauma; bronchoscopy; cervical spine; cervical spine injury; data base; emergency health service; fiberoptic bronchoscopy; hypothesis; injury scale; intensive care unit; medical record; postoperative hemorrhage; register; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70191548
DOI
  10.1097/01.ccm.0000365439.11849.a2
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000365439.11849.a2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000365439.11849.a2&atitle=Safety+of+percutaneous+tracheostomy+in+trauma+patients&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=37&issue=12&spage=A70&epage=&aulast=Maldonado&aufirst=Ivan&auinit=I.&aufull=Maldonado+I.&coden=&isbn=&pages=A70-&date=2009&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 750
TITLE
  A regional survey of paediatric consultants' practices and attitudes in the 
management of spinal muscular atrophy type 1
AUTHOR NAMES
  Heraghty J.L.; Hilliard T.N.; Majumdar A.; Jardine P.; Fleming P.J.; Henderson A.J.
AUTHOR ADDRESSES
  (Heraghty J.L.; Jardine P.; Fleming P.J.; Henderson A.J.) University of 
Bristol, Bristol, United Kingdom.
(Hilliard T.N.; Majumdar A.) Bristol Royal Hospital for Children, Bristol, 
United Kingdom.
CORRESPONDENCE ADDRESS
  J.L. Heraghty, University of Bristol, Bristol, United Kingdom.
FULL RECORD ENTRY DATE
  2010-09-07
SOURCE
  Thorax (2009) 64 SUPPL. 4 (A100). Date of Publication: December 2009
VOLUME
  64
FIRST PAGE
  A100
DATE OF PUBLICATION
  December 2009
CONFERENCE NAME
  British Thoracic Society, BTS Winter Meeting 2009
CONFERENCE LOCATION
  London, United Kingdom
CONFERENCE DATE
  2009-12-02 to 2009-12-04
ISSN
  0040-6376
BOOK PUBLISHER
  BMJ Publishing Group
ABSTRACT
  The management options for spinal muscular atrophy (SMA) are changing with 
an increase in the use of non-invasive and invasive ventilation. However, 
there are few empirical data to support the practice of long-term 
ventilation in improving quality of life in these patients. Without active 
respiratory management, children with SMA usually die within the first 2 
years of life. We designed a survey to assess current attitudes and 
practices in the management of this condition in a single geographical 
region of the UK. Methods: In November 2008 a web-based anonymous survey was 
sent to all paediatric consultants within the region who would have 
potential contact with a child with SMA. Following a brief clinical scenario 
of an infant with SMA type 1, a number of management options were suggested 
regarding general health care, antibiotics for infection, feeding options, 
immunisations, ventilation for acute illness and long-term home ventilation. 
For each option, respondents were asked if they would (a) not discuss, (b) 
discuss but not recommend or (c) recommend the intervention. Results: 72% 
(133/185) of consultants completed the survey. They were representative of 
the surveyed population in terms of place of work and specialty practice. 
83% of respondents would recommend nasogastric feeding, 79% oral antibiotics 
and 39% intravenous antibiotics during infections. 73% would recommend 
influenza and pneumococcal vaccination and 44% would recommend RSV 
prophylaxis. Non-invasive ventilation (NIV) would be recommended for the 
acute management of a respiratory infection by 52% but only 14% would 
recommend intubation and ventilation, although 82% said they would discuss 
this with the family. A high proportion of respondents would discuss 
long-term ventilation with NIV (72%) or tracheostomy (73%) ventilation but 
only 18% would recommend NIV and 8% would recommend long-term tracheostomy 
ventilation. Recommending referral to specialist services varied by 
specialty; 83% to palliative care, 79% to neurology and 65% to respiratory 
medicine. Conclusions: This preliminary survey suggests a variation in what 
interventions are recommended to families of children with SMA type 1 but 
indicates that a high proportion of respondents would discuss the majority 
of management options with the family.
EMTREE DRUG INDEX TERMS
  antibiotic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  consultation; society; spinal muscular atrophy; winter; 
EMTREE MEDICAL INDEX TERMS
  acute disease; air conditioning; child; feeding; health care; infant; infection; influenza; intubation; medical specialist; neurology; nose feeding; palliative therapy; patient; population; prophylaxis; quality of life; respiratory tract infection; tracheostomy; United Kingdom; vaccination; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70254600
DOI
  10.1136/thx.2009.127142h
FULL TEXT LINK
  http://dx.doi.org/10.1136/thx.2009.127142h
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00406376&id=doi:10.1136%2Fthx.2009.127142h&atitle=A+regional+survey+of+paediatric+consultants%27+practices+and+attitudes+in+the+management+of+spinal+muscular+atrophy+type+1&stitle=Thorax&title=Thorax&volume=64&issue=&spage=A100&epage=&aulast=Heraghty&aufirst=J.L.&auinit=J.L.&aufull=Heraghty+J.L.&coden=&isbn=&pages=A100-&date=2009&auinit1=J&auinitm=L
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 751
TITLE
  Diaphragmatic paralysis in a patient with spinal cord infarction
AUTHOR NAMES
  Matsumoto H.; Nakayama T.; Hamaguchi H.; Nakamori T.; Ikagawa T.; Oda T.; Imafuku I.
AUTHOR ADDRESSES
  (Matsumoto H., hideyukimatsumoto@mail.goo.ne.jp; Nakayama T.; Hamaguchi H.; 
Nakamori T.; Ikagawa T.; Oda T.; Imafuku I.) Department of Neurology, 
Yokohama Rosai Hospital, Yokohama, Japan.
CORRESPONDENCE ADDRESS
  H. Matsumoto, Department of Neurology, Yokohama Rosai Hospital, Yokohama, 
Japan. Email: hideyukimatsumoto@mail.goo.ne.jp
FULL RECORD ENTRY DATE
  2010-02-10
SOURCE
  Internal Medicine (2009) 48:19 (1763-1766). Date of Publication: 2009
VOLUME
  48
ISSUE
  19
FIRST PAGE
  1763
LAST PAGE
  1766
DATE OF PUBLICATION
  2009
ISSN
  0918-2918
  1349-7235 (electronic)
BOOK PUBLISHER
  Japanese Society of Internal Medicine, 34-3, 3-chome, Hongo, Bunkyo-ku, 
Tokyo, Japan.
ABSTRACT
  This report describes the rare case of a 72-year-old woman with spinal cord 
infarction who presented with persistent diaphragmatic paralysis. Her 
neurological examination showed tetraplegia, sensory loss to pain and 
thermal stimulations, and paradoxical abdominal movement. Chest X-ray and 
diaphragmatic fluoroscopy revealed absent diaphragmatic movement. A cervical 
magnetic resonance image showed bilateral anterior spinal cord lesions from 
the level of the second to the fifth cervical vertebrae. Diaphragmatic 
paralysis should be recognized as a clinical sign of cervical spinal cord 
infarction. Particular attention must be given to paradoxical abdominal 
movement during respiration in this disorder. © 2009 The Japanese Society of 
Internal Medicine.
EMTREE DRUG INDEX TERMS
  acetylsalicylic acid (drug therapy); antihypertensive agent (drug therapy); heparin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm paralysis; spinal cord ischemia (drug therapy, diagnosis, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  aged; article; Babinski reflex; body temperature; case report; consciousness; dyspnea; elderly care; female; fluoroscopy; human; hypertension (drug therapy); magnetic resonance angiography; nuclear magnetic resonance imaging; oxygen saturation; polysomnography; positive end expiratory pressure; pulse rate; quadriplegia; tendon reflex; thorax radiography; tracheostomy; tracheotomy; 
CAS REGISTRY NUMBERS
  acetylsalicylic acid (493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009607957
MEDLINE PMID
  19797834 (http://www.ncbi.nlm.nih.gov/pubmed/19797834)
PUI
  L355695308
DOI
  10.2169/internalmedicine.48.2334
FULL TEXT LINK
  http://dx.doi.org/10.2169/internalmedicine.48.2334
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09182918&id=doi:10.2169%2Finternalmedicine.48.2334&atitle=Diaphragmatic+paralysis+in+a+patient+with+spinal+cord+infarction&stitle=Intern.+Med.&title=Internal+Medicine&volume=48&issue=19&spage=1763&epage=1766&aulast=Matsumoto&aufirst=Hideyuki&auinit=H.&aufull=Matsumoto+H.&coden=IEDIE&isbn=&pages=1763-1766&date=2009&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 752
TITLE
  Respiratory problems in spinal muscular atrophy in the paediatric age group
AUTHOR NAMES
  Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera R.
AUTHOR ADDRESSES
  (Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera 
R.) MB Chiarini Testa MD is Senior Registrer on the Respiratory Unit, 
Pediatric Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, 
Italy.
(Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera 
R.) MG Paglietti MD is Senior Registrer on the Respiratory Unit, Pediatric 
Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
(Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera 
R.) M Pavone MD is Senior Registrer on the Respiratory Unit, Pediatric 
Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
(Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera 
R.) Pediatric Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, 
Italy.
(Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera 
R.) Pediatric Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, 
Italy.
(Testa M.B.C.; Paglietti M.G.; Pavone M.; Schiavino A.; Pedace C.; Cutrera 
R.) Pediatric Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, 
Italy.
CORRESPONDENCE ADDRESS
  M.B.C. Testa, MB Chiarini Testa MD is Senior Registrer on the Respiratory 
Unit, Pediatric Medicine Department, Ospedale Pediatrico Bambino Gesù, Rome, 
Italy.
FULL RECORD ENTRY DATE
  2010-01-15
SOURCE
  Paediatrics and Child Health (2009) 19:SUPPL. 2 (S123-S126). Date of 
Publication: December 2009
VOLUME
  19
ISSUE
  SUPPL. 2
DATE OF PUBLICATION
  December 2009
ISSN
  1751-7222
BOOK PUBLISHER
  Churchill Livingstone, 1-3 Baxter's Place, Leith Walk, Edinburgh, United 
Kingdom.
ABSTRACT
  The patient with neuromuscular disability (spinal muscular atrophy, muscular 
dystrophy, myopathy, amyotrophic lateral sclerosis, post-poliomyelitis 
syndrome or neuropathy) represents a typical example of a child with chronic 
respiratory disease requiring either hospitalisation or domiciliary 
assistance. For these patients, respiratory disease represents the main 
cause of morbidity and mortality, due primarily to weakness of the 
respiratory muscles, an ineffective cough and abnormal swallowing. A 
multidisciplinary approach, with the aim of improving the patient's quality 
of life, is therefore required. Such an approach involves various 
strategies, for example use of the cough-assist machine (a non-invasive 
respiratory physiotherapy that safely and consistently removes secretions in 
patients with an ineffective ability to cough), monitoring of nutritional 
status, the prevention of chest deformities, and the use of mechanically 
assisted ventilation - both non-invasive and invasive ventilation via a 
tracheotomy. © 2009.
EMTREE DRUG INDEX TERMS
  bicarbonate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chronic respiratory tract disease; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  adverse outcome; amyotrophic lateral sclerosis; article; artificial ventilation; aspiration pneumonia (complication); bicarbonate blood level; breathing exercise; breathing muscle; child; claustrophobia (complication); clinical assessment; coughing; dysphagia; end tidal carbon dioxide tension; eye irritation (complication); face erythema (complication); function test; gas exchange; groups by age; human; hypercapnia; hypotension (complication); hypoventilation; hypoxemia; lung clearance; morbidity; mortality; muscular dystrophy; myopathy; neuropathy; nose cavity; nose obstruction (complication); nutritional assessment; otalgia (complication); oxygen mask; pediatrics; physical examination; pneumothorax (complication); polysomnography; positive end expiratory pressure; postpoliomyelitis syndrome; pulse oximetry; quality of life; REM sleep; sinusitis (complication); sleep disordered breathing; thorax deformity; tracheotomy; transcutaneous carbon dioxide monitoring; ulcer (complication); 
CAS REGISTRY NUMBERS
  bicarbonate (144-55-8, 71-52-3)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009644091
PUI
  L355794122
DOI
  10.1016/j.paed.2009.08.017
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.paed.2009.08.017
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17517222&id=doi:10.1016%2Fj.paed.2009.08.017&atitle=Respiratory+problems+in+spinal+muscular+atrophy+in+the+paediatric+age+group&stitle=Paediatr.+Child+Health+%28GBR%29&title=Paediatrics+and+Child+Health&volume=19&issue=SUPPL.+2&spage=&epage=&aulast=Testa&aufirst=M.B.+Chiarini&auinit=M.B.C.&aufull=Testa+M.B.C.&coden=&isbn=&pages=-&date=2009&auinit1=M&auinitm=B.C.
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 753
TITLE
  Primary pyogenic infection of the cervical spine in intravenous drug users
AUTHOR NAMES
  Street J.; Lenehan B.; Fisher C.
AUTHOR ADDRESSES
  (Street J.; Lenehan B.; Fisher C.) Vancouver, Canada.
CORRESPONDENCE ADDRESS
  J. Street, Vancouver, Canada.
FULL RECORD ENTRY DATE
  2010-12-28
SOURCE
  Spine (2009). Date of Publication: 2009
DATE OF PUBLICATION
  2009
CONFERENCE NAME
  37th Annual Meeting of the Cervical Spine Research Society, CSRS 2009
CONFERENCE LOCATION
  Salt Lake City, UT, United States
CONFERENCE DATE
  2009-12-03 to 2009-12-05
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Objectives: To evaluate the demographics, presentation, treatment and 
outcomes of primary Pyogenic infection of the cervical spine in a population 
of intravenous drug users. Methods: Data on all patients with primary 
pyogenic infection of the cervical spine presenting to a quaternary referral 
center was obtained from a prospectively maintained database. Results: Over 
the 5 year study period there were 102 patients treated for Primary Pyogenic 
Infection of the Cervical Spine of which 51 were Intravenous Drug Users 
(IVDU). Of this IVDU group there were 34 males. Mean age was 43years (range 
25 - 57). 23 had HIV, 43 Hepatitis C and 13 Hepatitis B. All were using 
cocaine, 26 were also using Heroin and 44 more than 3 recreational drugs. 30 
patients presented with axial pain with a mean duration of 51 days (range 
3-120). 31 were ASIA D or worse with 8 ASIA A. Mean Motor Score of patients 
with deficit was 58.6. Most common ASIA Motor Levels were C4 and C5. Mean 
duration of neurological symptoms was 7 days (range 1-60). None had previous 
surgery for spinal infection. 26 were receiving IV antibiotics for known 
spinal infection. Mean presenting Temperature was 37.4 degrees C(range 35.9 
- 39.9, 19 > 37.5C), mean ESR 60.8 (range 6 - 140, 43 > 20), mean CRP 87.75 
(1.5-253, 46 > 20), meanWCC 10.2 (range 3.7 - 30.4, 14 > 11) and 33 patients 
had positive blood cultures (19 MSSA, 9 MRSA). 44 patients were treated 
surgically. 22 had a posterior approach alone, 13 had anterior only while 9 
required combined.Mean operative time was 263 mins (range 62 - 742). 13 
required tracheostomy. 7 required early revision for hardware failure and 2 
for surgical wound infection. Mean duration of antibiotic treatment was 49 
days (range 28-116). 26 patients had single agent therapy. 17 hadMSSAand 
17MRSA.At discharge 28 patients had neurological improvement (mean 20 ASIA 
points, range 1-55), 11 had deterioration (mean 13, range 1-50) and 5 were 
unchanged. There were no in-hospital deaths. At 2 years after index 
admission 13 patients were dead and the remainder had failed to attend the 
unit for follow-up. Conclusions: Primary pyogenic infection of the cervical 
spinal in IVDU's typically presents with sepsis and acute cervical 
quadriplegia. Surgical management must be prompt and aggressive with 
significant neurological improvement expected in the majority of patients.
EMTREE DRUG INDEX TERMS
  antibiotic agent; cocaine; diamorphine; recreational drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; infection; intravenous drug abuse; society; 
EMTREE MEDICAL INDEX TERMS
  antibiotic therapy; blood culture; computer; data base; death; deterioration; follow up; hepatitis; hepatitis C; hospital; Human immunodeficiency virus; male; methicillin resistant Staphylococcus aureus; neurologic disease; pain; patient; population; quadriplegia; Quaternary (period); sepsis; surgery; surgical infection; temperature; therapy; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70314353
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:&atitle=Primary+pyogenic+infection+of+the+cervical+spine+in+intravenous+drug+users&stitle=Spine&title=Spine&volume=&issue=&spage=&epage=&aulast=Street&aufirst=John&auinit=J.&aufull=Street+J.&coden=&isbn=&pages=-&date=2009&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 754
TITLE
  Chest radiography after tracheostomy: Is there a benefit?
AUTHOR NAMES
  Agarwal S.; Tobler W.; Mella J.; Selvam A.; Ng J.; Burke P.
AUTHOR ADDRESSES
  (Agarwal S.; Burke P.) Boston Medical Center, United States.
(Tobler W.; Mella J.; Selvam A.; Ng J.) Boston University, School of 
Medicine, United States.
CORRESPONDENCE ADDRESS
  S. Agarwal, Boston Medical Center, United States.
FULL RECORD ENTRY DATE
  2010-07-13
SOURCE
  Critical Care Medicine (2009) 37:12 SUPPL. (A6). Date of Publication: 
December 2009
VOLUME
  37
ISSUE
  12
FIRST PAGE
  A6
DATE OF PUBLICATION
  December 2009
CONFERENCE NAME
  39th Critical Care Congress of the Society of Critical Care Medicine's
CONFERENCE LOCATION
  Miami Beach, FL, United States
CONFERENCE DATE
  2010-01-09 to 2010-01-13
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Introduction: Routine Chest X-Ray (CXR) after tracheostomy remains a widely 
accepted practice despite lack of evidence supporting clinical utility. 
Hypothesis: Establishment of a policy utilizing clinical exam after 
tracheostomy will reduce cost and minimize patient exposure to radiation. 
Methods: A retrospective review of all tracheostomy at a trauma intensive 
care unit over a 5 year period was performed. Preoperative and postoperative 
CXR and chart documentation were evaluated to determine clinical 
significance. Significant findings on CXR included new 
pneumothorax/subcutaneous emphysema or an increase in consolidation or 
effusion. The cost of portable CXR was estimated to be $500 per event. 
Results: A total of 255 tracheostomies were included: 131 open 
tracheostomies (105 male, 26 female) and 112 percutaneous tracheostomies (93 
male and 19 females) and 22 patients were excluded due to inadequate 
documentation. Age ranged from 12-93 years. Procedures were performed from 
hospital day 1 to day 46. Indications included respiratory failure (214) and 
traumatic brain or spinal cord injury (41). Positive findings were found on 
7 CXR after the procedure: 6 patients were managed prior to CXR based on 
clinical presentation, and the 7th patient was observed for a deep sulcus 
sign which resolved spontaneously. An additional 4 patients had worsening 
clinical picture without change in CXR. The remaining 244 patients (95.6%) 
had no change in CXR after the procedure and a stable clinical picture. A 
cost savings of $122,000 could have been realized if a protocol utilizing 
clinical exam been utilized. Conclusions: Routine CXR following tracheostomy 
fails to provide additional information above clinical examination. Clinical 
deterioration should be the stimulus for radiographic examination. Such a 
protocol can result in significant cost savings and minimize patient 
exposure to radiation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; society; thorax radiography; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  brain; clinical examination; cost control; deterioration; documentation; effusion; emphysema; exposure; female; hospital; hypothesis; injury; intensive care unit; male; patient; policy; radiation; radiodiagnosis; respiratory failure; spinal cord injury; stimulus; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70191426
DOI
  10.1097/01.ccm.0000365439.11849.a2
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000365439.11849.a2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000365439.11849.a2&atitle=Chest+radiography+after+tracheostomy%3A+Is+there+a+benefit%3F&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=37&issue=12&spage=A6&epage=&aulast=Agarwal&aufirst=Suresh&auinit=S.&aufull=Agarwal+S.&coden=&isbn=&pages=A6-&date=2009&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 755
TITLE
  Spinal muscular atrophy type 1: Prolongation of survival by noninvasive 
respiratory aids
AUTHOR NAMES
  Bach J.R.; Gupta K.; Reyna M.; Hon A.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu; Gupta K.; Reyna M.; Hon A.) Department of 
Neurosciences, University of Medicine and Dentistry of New Jersey, New 
Jersey Medical School, Newark, NJ, United States.
CORRESPONDENCE ADDRESS
  J. R. Bach, Department of Physical Medicine and Rehabilitation, University 
Hospital B-403, 150 Bergen Street, Newark, NJ 07871, United States. Email: 
bachjr@umdnj.edu
AiP/IP ENTRY DATE
  2010-03-23
FULL RECORD ENTRY DATE
  2010-04-19
SOURCE
  Pediatric Asthma, Allergy and Immunology (2009) 22:4 (151-161). Date of 
Publication: 1 Dec 2009
VOLUME
  22
ISSUE
  4
FIRST PAGE
  151
LAST PAGE
  161
DATE OF PUBLICATION
  1 Dec 2009
ISSN
  0883-1874
BOOK PUBLISHER
  Mary Ann Liebert Inc., 140 Huguenot Street, New Rochelle, United States.
ABSTRACT
  Previous reports on spinal muscular atrophy type 1 (SMA-1) underestimate 
potential survival because of failure to optimally use noninvasive 
respiratory muscle aids including mechanically assisted coughing and 
noninvasive ventilation (NIV) at full support settings. We report our 
center's experience in prolonging survival for these patients. We focus on 
early initiation of nasal noninvasive ventilation, mechanically assisted 
coughing, and pulse oximetry monitoring during acute respiratory tract 
infections to guide use of assistive technologies. Seventeen SMA-1 patients 
with ventilation via tracheostomy are living, with a mean age of 78.2 (range 
65-179) months. Ten died at a mean age of 61.6 (range 16-270) months of age. 
Twenty five of 27 were not able to regain autonomous breathing ability after 
the tracheostomy. None of the 21 who had not developed the ability to 
verbalize before undergoing tracheotomy did so after tracheotomy. Six 
patients had comprehendible speech at the time of tracheotomy and retained 
some ability to vocalize subsequently. Seventy-two SMA-1 patients using 
noninvasive ventilation are alive at mean age 86.1 (range 13-196) months; 13 
died at 52.3 (range 13-111) months. Sixty seven of the 75 could communicate 
verbally. The noninvasive ventilation patients had significantly more 
hospitalizations than tracheostomy patients until age 3 (P < 0.001) but not 
thereafter. SMA-1 survival past adolescence is possible using both 
noninvasive ventilation and tracheostomy ventilation. The 
tracheostomy-ventilated patients had greater levels of ventilator dependence 
and reduced verbal abilities. © 2010 Mary Ann Liebert, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure (complication, etiology, therapy); spinal muscular atrophy (etiology); 
EMTREE MEDICAL INDEX TERMS
  adolescent; assisted ventilation; child; clinical article; coughing; human; intensive care; male; non invasive procedure; outcome assessment; preschool child; priority journal; review; school child; speech intelligibility; survival time; tracheotomy; vocalization; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2010165822
PUI
  L358440436
DOI
  10.1089/pai.2009.0002
FULL TEXT LINK
  http://dx.doi.org/10.1089/pai.2009.0002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08831874&id=doi:10.1089%2Fpai.2009.0002&atitle=Spinal+muscular+atrophy+type+1%3A+Prolongation+of+survival+by+noninvasive+respiratory+aids&stitle=Pediatr.+Asthma+Allergy+Immunol.&title=Pediatric+Asthma%2C+Allergy+and+Immunology&volume=22&issue=4&spage=151&epage=161&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=PAAIE&isbn=&pages=151-161&date=2009&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 756
TITLE
  Selective intrabronchial air insufflation: A potentially life saving 
treatment for acute lobar collapse
AUTHOR NAMES
  Wohlauer M.; Moore E.; Haenel J.; Burlew C.; Barnett C.
AUTHOR ADDRESSES
  (Wohlauer M.) University of Colorado Denver, United States.
(Moore E.; Haenel J.; Burlew C.; Barnett C.) Denver Health Medical Center, 
United States.
CORRESPONDENCE ADDRESS
  M. Wohlauer, University of Colorado Denver, United States.
FULL RECORD ENTRY DATE
  2010-07-13
SOURCE
  Critical Care Medicine (2009) 37:12 SUPPL. (A496). Date of Publication: 
December 2009
VOLUME
  37
ISSUE
  12
FIRST PAGE
  A496
DATE OF PUBLICATION
  December 2009
CONFERENCE NAME
  39th Critical Care Congress of the Society of Critical Care Medicine's
CONFERENCE LOCATION
  Miami Beach, FL, United States
CONFERENCE DATE
  2010-01-09 to 2010-01-13
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins
ABSTRACT
  Background: Lobar atelectasis is a frequently encountered problem in the 
ICU, caused by a variety of mechanisms. There are few options for critically 
ill patients when traditional methods fail, posing a formidable challenge 
for the intensivist. A middle aged female unrestrained passenger in a motor 
vehicle crash was transferred to Denver Health Medical Center, the regional 
Level One Trauma Center, with a C4 tetraplegia and complete right carotid 
artery occlusion. She arrived intubated, on pressors, with a heart rate in 
the 40's. She underwent operative fixation of her spinal cord injury and a 
tracheostomy was performed for respiratory failure. On hospital day 8 she 
became febrile, hypotensive and increasingly hypoxemic with a P:F ratio of 
95. A chest radiograph demonstrated collapse of the right lower lobe. She 
developed profound hypoxemia, with persistent right lower lobe collapse (see 
image). Increased PEEP exacerbated her condition due to high peak pressures. 
She underwent emergent repeat FFB followed by selective intrabronchial air 
insufflation (SII) to expand the atelectatic lung (see image). The 
radiograph reflects immediate clinical improvement, with decreased oxygen 
requirements and normalization of blood pressure upon reinflation of the 
distal airways. Methods: Selective Intrabronchial Air Insufflation: An 
adapter from a Mallinckrodt 3.0 mm uncuffed tracheal tube is inserted on to 
a bronchoscope [Mallinckrodt Inc., St. Louis, MO]. The bronchoscope is 
inserted, and the patient's airways are examined. After routine suctioning 
and lavage, the bronchoscope is advanced into the collapsed bronchial 
segment. The suction tubing is occluded in order to prepare for selective 
air insufflation. After attaching a manual resuscitator (i.e. bag valve 
mask), 5-10 positive pressure breaths are applied into every segment of 
collapsed lobe while monitoring for hypotension. These breaths are delivered 
by interfacing the manual resuscitator connected to the 3.0 mm adapter, via 
a three-way stopcock to the FFB instrument port. Discussion: Lobar 
atelectasis is a frequently encountered problem in the ICU, caused by a 
variety of mechanisms including resorption atelectasis due to airway 
obstruction, passive atelectasis from hypoventilation, compressive 
atelectasis from abdominal distension, and adhesive atelectasis due to 
increased surface tension. Common treatments include chest physiotherapy, 
bronchodilators, fiberoptic bronchoscopy, Dnase, positive end-expiratory 
pressure, and surfactant. As alveolar radius decreases, surface tension 
increases resulting in alveoli collapse. Once collapsed, a substantial 
airway pressure must be generated in order to reexpand the distal airways. 
Traditional respiratory therapy can cause injurious transpulmonary pressures 
in the non-collapsed lung leading to injury, however, SII easily re-expanded 
collapsed lobes without overinflation in a canine study. A series of 17 ICU 
patients previously published by our institution showed FFB with SII to be 
82% effective in patients with lobar collapse. Selective intrabronchial air 
insufflation (SII) is a simple and potentially life-saving adjunct to FFB in 
the treatment of ICU patients with acute pulmonary lobar collapse.(Figure 
presented).
EMTREE DRUG INDEX TERMS
  adhesive agent; antihypertensive agent; deoxyribonuclease; hypertensive factor; surfactant; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aeration; intensive care; intrabronchial drug administration; society; 
EMTREE MEDICAL INDEX TERMS
  abdominal distension; airway; airway obstruction; airway pressure; artificial ventilation; atelectasis; blood pressure; book; breathing; breathing exercise; bronchoscope; carotid artery obstruction; critically ill patient; emergency health service; endotracheal tube; female; fiberoptic bronchoscopy; health; heart rate; hospital; hypotension; hypoventilation; hypoxemia; injury; lavage; lung; middle aged; monitoring; motor vehicle; oxygen consumption; patient; positive end expiratory pressure; quadriplegia; radius; respiratory failure; spinal cord injury; suction; surface tension; thorax radiography; tracheostomy; X ray film; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70192385
DOI
  10.1097/01.ccm.0000365439.11849.a2
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ccm.0000365439.11849.a2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F01.ccm.0000365439.11849.a2&atitle=Selective+intrabronchial+air+insufflation%3A+A+potentially+life+saving+treatment+for+acute+lobar+collapse&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=37&issue=12&spage=A496&epage=&aulast=Wohlauer&aufirst=Max&auinit=M.&aufull=Wohlauer+M.&coden=&isbn=&pages=A496-&date=2009&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 757
TITLE
  Cervical spinal cord infarction after posterior fossa surgery: A case-based 
update
AUTHOR NAMES
  Martínez-Lage J.F.; Almagro M.-J.; Izura V.; Serrano C.; Ruiz-Espejo A.M.; Sánchez-Del-Rincón I.
AUTHOR ADDRESSES
  (Martínez-Lage J.F., juanf.martinezlage@cablemurcia.com; Almagro M.-J.; 
Ruiz-Espejo A.M.) Unit of Pediatric Neurosurgery, Regional Service of 
Neurosurgery, Virgen de la Arrixaca University Hospital, El Palmar, Murcia 
30120, Spain.
(Izura V.) Service of Clinical Neurophysiology, Virgen de la Arrixaca 
University Hospital, El Palmar, Murcia 30120, Spain.
(Serrano C.) Department of Radiodiagnostics (Pediatric Radiology), Virgen de 
la Arrixaca University Hospital, El Palmar, Murcia 30120, Spain.
(Sánchez-Del-Rincón I.) Pediatric Anesthesia, Virgen de la Arrixaca 
University Hospital, El Palmar, Murcia 30120, Spain.
CORRESPONDENCE ADDRESS
  J. F. Martínez-Lage, Unit of Pediatric Neurosurgery, Regional Service of 
Neurosurgery, Virgen de la Arrixaca University Hospital, El Palmar, Murcia 
30120, Spain. Email: juanf.martinezlage@cablemurcia.com
FULL RECORD ENTRY DATE
  2009-12-25
SOURCE
  Child's Nervous System (2009) 25:12 (1541-1546). Date of Publication: 
December 2009
VOLUME
  25
ISSUE
  12
FIRST PAGE
  1541
LAST PAGE
  1546
DATE OF PUBLICATION
  December 2009
ISSN
  0256-7040
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Background: Several positions are currently utilized for operating patients 
with posterior fossa lesions. Each individual position has its own risks and 
benefits, and none has demonstrated its superiority. A dreaded, and probably 
underreported, complication of these procedures is cervical cord infarction 
with quadriplegia. Discussion: We reviewed eight previous reported instances 
of this devastating complication aimed at ascertaining its pathogenesis to 
suggest preventive strategies. Several hypotheses have been put forward to 
explain the occurrence of this complication. Some factors involved in the 
production of cervical cord infarction include patient"s position (seated or 
prone), hyperflexion of the neck, excessive spinal cord traction, canal 
stenosis, and systemic arterial hypotension. We hypothesize that spinal cord 
infarction in our patient might have resulted from compromised blood supply 
to the midcervical cord caused by tumor infiltration of the cervical 
leptomeninges in addition to a brief episode of arterial hypotension during 
venous air embolism. Case report: We treated an 8-year-old girl who 
developed quadriplegia after surgery for a fourth ventricular ependymoma. 
Postoperative magnetic resonance imaging demonstrated cervical cord 
infarction. Evoked potentials confirmed the diagnosis. Conclusions: With 
this report, we want to draw the attention of neurosurgeons to the 
possibility of the occurrence of this dreadful complication during posterior 
fossa procedures. Retrospectively, the only measures that might have helped 
to avoid this complication in our patient would have been using the prone 
position and intraoperative monitoring of evoked potentials. © 2009 
Springer-Verlag.
EMTREE DRUG INDEX TERMS
  dexamethasone (drug therapy); Ki 67 antigen (endogenous compound); protein p53 (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord infarction (drug therapy, complication, diagnosis, drug 
therapy, etiology); cervical spinal cord injury (drug therapy, complication, diagnosis, drug 
therapy, etiology); 
EMTREE MEDICAL INDEX TERMS
  acoustic neuroma (surgery); adolescent; adult; aged; air embolism; anorexia; Arnold Chiari malformation (surgery); astrocytoma (surgery); bradycardia; brain fourth ventricle; brain ventricle peritoneum shunt; cervical spinal cord; child; choriocarcinoma (surgery); choroid plexus papilloma (surgery); clinical article; cranial nerve paralysis (complication); drowsiness; drug megadose; early diagnosis; ependymoma (surgery); evoked brain stem response; evoked response; female; headache; heart ventricle pressure; human; hydrocephalus; hyperreflexia; hypotension (complication); laminectomy; male; medulloblastoma (surgery); neck pain; neurography; neuropathology; nuclear magnetic resonance imaging; paraplegia (complication, rehabilitation); paresis (complication, rehabilitation); paresthesia; pathogenesis; patient positioning; phrenic nerve; posterior fossa; postoperative care; preschool child; priority journal; quadriplegia (complication, rehabilitation); review; school child; somatosensory evoked potential; systolic blood pressure; tomotherapy; tracheotomy; vascularization; vertebral canal stenosis (complication); vertigo; vomiting; 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  General Pathology and Pathological Anatomy (5)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009590175
MEDLINE PMID
  19590878 (http://www.ncbi.nlm.nih.gov/pubmed/19590878)
PUI
  L50576316
DOI
  10.1007/s00381-009-0950-3
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-009-0950-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-009-0950-3&atitle=Cervical+spinal+cord+infarction+after+posterior+fossa+surgery%3A+A+case-based+update&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=25&issue=12&spage=1541&epage=1546&aulast=Mart%C3%ADnez-Lage&aufirst=Juan+F.&auinit=J.F.&aufull=Mart%C3%ADnez-Lage+J.F.&coden=CNSYE&isbn=&pages=1541-1546&date=2009&auinit1=J&auinitm=F
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 758
TITLE
  Use of isocentric fluoroscopy during transoral odontoidectomy
AUTHOR NAMES
  Mammis A.; Yanni D.S.; Goldstein I.M.
AUTHOR ADDRESSES
  (Mammis A.; Yanni D.S.; Goldstein I.M., goldstir@umdnj.edu) Department of 
Neurosurgery, New Jersey Medical School, Suite 8100, 90 Bergen Street, 
Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  I.M. Goldstein, Department of Neurosurgery, New Jersey Medical School, Suite 
8100, 90 Bergen Street, Newark, NJ 07103, United States. Email: 
goldstir@umdnj.edu
AiP/IP ENTRY DATE
  2009-10-20
FULL RECORD ENTRY DATE
  2009-12-29
SOURCE
  Journal of Clinical Neuroscience (2009) 16:12 (1624-1627). Date of 
Publication: December 2009
VOLUME
  16
ISSUE
  12
FIRST PAGE
  1624
LAST PAGE
  1627
DATE OF PUBLICATION
  December 2009
ISSN
  0967-5868
BOOK PUBLISHER
  Churchill Livingstone, 1-3 Baxter's Place, Leith Walk, Edinburgh, United 
Kingdom.
ABSTRACT
  The intra-operative isocentric C-arm (Siremobil Iso-C 3D; Siemens Medical 
Solutions, Erlangen, Germany) allows for the acquisition and immediate 
interpretation of multiplanar three-dimensional images. The utility of 
isocentric fluoroscopy in surgery of the spine has been well described, in 
patients with percutaneous kyphoplasty, anterior cervical discectomy and 
fusion, fracture repair, as well as in percutaneous instrumentation at 
cervical, thoracic and lumbar levels. Two patients who underwent transoral 
odontoidectomy are presented in whom isocentric fluoroscopy was utilized to 
provide an intra-operative CT scan. Use of this technology allowed the 
surgeon to detect residual bone peri-operatively, thus allowing for a more 
extensive decompression and excellent clinical results. Intra-operative 
isocentric fluoroscopy in transoral odontoidectomy allows for peri-operative 
detection of residual bone fragments and intra-operative confirmation of 
complete decompression. © 2009 Elsevier Ltd. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dens axis resection; fluoroscopy; spinal cord surgery; surgical technique; 
EMTREE MEDICAL INDEX TERMS
  Arnold Chiari malformation (diagnosis, therapy); article; basilar impression (diagnosis, surgery, therapy); case report; cervical spine; child; computer assisted tomography; craniectomy; discectomy; Down syndrome; female; follow up; fracture fixation; human; kyphoplasty; laminectomy; lumbar spine; male; mild cognitive impairment; muscle hypertonia; nuclear magnetic resonance imaging; perioperative period; peroperative care; physical examination; postoperative care; preschool child; priority journal; radiography; range of motion; sleep disordered breathing; spinal cord compression (diagnosis); spine surgery; subluxation (diagnosis, surgery, therapy); surgical approach; thoracic spine; three dimensional imaging; tracheostomy; traction therapy; 
DEVICE TRADE NAMES
  Miami-J  , IcelandOssur

  Siremobil Iso  , GermanySiemens Medical Solutions

DEVICE MANUFACTURERS
   (United States)Orthofix
   (Iceland)Ossur
   (Germany)Siemens Medical Solutions
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009578449
MEDLINE PMID
  19819700 (http://www.ncbi.nlm.nih.gov/pubmed/19819700)
PUI
  L50668870
DOI
  10.1016/j.jocn.2009.02.034
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jocn.2009.02.034
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09675868&id=doi:10.1016%2Fj.jocn.2009.02.034&atitle=Use+of+isocentric+fluoroscopy+during+transoral+odontoidectomy&stitle=J.+Clin.+Neurosci.&title=Journal+of+Clinical+Neuroscience&volume=16&issue=12&spage=1624&epage=1627&aulast=Mammis&aufirst=Antonios&auinit=A.&aufull=Mammis+A.&coden=JCNUE&isbn=&pages=1624-1627&date=2009&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 759
TITLE
  Multidisciplinary management of Hunter syndrome
AUTHOR NAMES
  Muenzer J.; Beck M.; Eng C.M.; Escolar M.L.; Giugliani R.; Guffon N.H.; Harmatz P.; Kamin W.; Kampmann C.; Koseoglu S.T.; Link B.; Martin R.A.; Molter D.W.; Rojas M.V.M.; Ogilvie J.W.; Parini R.; Ramaswami U.; Scarpa L.M.; Schwartz I.V.; Wood R.E.; Wraith E.
AUTHOR ADDRESSES
  (Muenzer J., muenzer@med.unc.edu; Escolar M.L.) Department of Pediatrics, 
Medical School, University of North Carolina at Chapel Hill, Chapel Hill, NC 
27599-7487, United States.
(Beck M.; Kamin W.; Kampmann C.) Villa Metabolica, Children's Hospital, 
University of Mainz, Mainz, Germany.
(Eng C.M.) Department of Molecular and Human Genetics, Baylor College of 
Medicine, Houston, TX, United States.
(Giugliani R.; Rojas M.V.M.; Schwartz I.V.) Hospital de Clinicas de Porto 
Alegre, Department of Genetics, Universidade Federal do Rio Grande do Sul, 
Porto Alegre, Brazil.
(Guffon N.H.) Hôpital Edouard Herriot Pavilion S, Maladies Metaboliques, 
Lyon, France.
(Harmatz P.; Koseoglu S.T.) Division of Ophthalmology, Children's Hospital 
and Research Center Oakland, Oakland, CA, United States.
(Link B.) Orthopedic Department, University Hospital Johannes 
Gutenberg-University, Mainz, Germany.
(Martin R.A.) Division of Medical Genetics, St. Louis University, St Louis, 
MO, United States.
(Molter D.W.) Department of Otolaryngology, Washington University in St. 
Louis, St Louis, MO, United States.
(Ogilvie J.W.) Department of Orthopaedic Surgery, University of Utah School 
of Medicine, St Lake City, UT, United States.
(Parini R.) Pediatric Department, Ospedale San Gerardo, Monza, Italy.
(Ramaswami U.) Paediatric Metabolic Unit, Addenbrooke's Hospital, Cambridge, 
United Kingdom.
(Scarpa L.M.) Department of Pediatrics, University of Padova, Padova, Italy.
(Wood R.E.) Division of Pulmonary Medicine, Cincinnati Children's Hospital 
Medical Center, Cincinnati, OH, United States.
(Wraith E.) Inherited Metabolic Medicine, Genetic Medicine, St. Mary's 
Hospital, Manchester, United Kingdom.
(Martin R.A.) Shire Human Genetic Therapies, Inc., Cambridge, MA, United 
States.
CORRESPONDENCE ADDRESS
  J. Muenzer, Department of Pediatrics, Medical School, University of North 
Carolina at Chapel Hill, Chapel Hill, NC 27599-7487, United States. Email: 
muenzer@med.unc.edu
FULL RECORD ENTRY DATE
  2010-01-04
SOURCE
  Pediatrics (2009) 124:6 (e1228-e1239). Date of Publication: December 2009
VOLUME
  124
ISSUE
  6
DATE OF PUBLICATION
  December 2009
ISSN
  0031-4005
  1098-4275 (electronic)
BOOK PUBLISHER
  American Academy of Pediatrics, 141 Northwest Point Blvd, P.O. Box 927, Elk 
Grove Village, United States.
ABSTRACT
  Hunter syndrome is a rare, X-linked disorder caused by a deficiency of the 
lysosomal enzyme iduronate-2-sulfatase. In the absence of sufficient enzyme 
activity, glycosaminoglycans accumulate in the lysosomes of many tissues and 
organs and contribute to the multisystem, progressive pathologies seen in 
Hunter syndrome. The nervous, cardiovascular, respiratory, and 
musculoskeletal systems can be involved in individuals with Hunter syndrome. 
Although the management of some clinical problems associated with the 
disease may seem routine, the management is typically complex and requires 
the physician to be aware of the special issues surrounding the patient with 
Hunter syndrome, and a multidisciplinary approach should be taken. 
Subspecialties such as otorhinolaryngology, neurosurgery, orthopedics, 
cardiology, anesthesiology, pulmonology, and neurodevelopment will all have 
a role in management, as will specialty areas such as physiotherapy, 
audiology, and others. The important management topics are discussed in this 
review, and the use of enzyme-replacement therapy with recombinant human 
iduronate-2-sulfatase as a specific treatment for Hunter syndrome is 
presented. Copyright © 2009 by the American Academy of Pediatrics.
EMTREE DRUG INDEX TERMS
  anticonvulsive agent (drug therapy); antihistaminic agent; beta adrenergic receptor stimulating agent (drug therapy); corticosteroid (drug therapy); epinephrine (drug therapy); glycosaminoglycan (endogenous compound); iduronate 2 sulfatase (adverse drug reaction, clinical trial, drug therapy, 
intravenous drug administration); placebo; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Hunter syndrome (drug therapy, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  airway obstruction (diagnosis, surgery, therapy); anaphylaxis (drug therapy, side effect); audiology; behavior disorder; bronchoscopy; carpal tunnel syndrome (surgery); clinical assessment; clinical feature; clinical trial; communicating hydrocephalus; controlled clinical trial; decompression surgery; diagnostic imaging; drug dose reduction; drug eruption (side effect); drug fever (side effect); drug induced headache (side effect); drug tolerability; drug withdrawal; dysphagia; echocardiography; enzyme activity; enzyme replacement; erythema (side effect); fibroblast; flushing; genotype; hearing aid; hearing impairment (surgery, therapy); heart disease (diagnosis); human; Hurler syndrome (therapy); intubation; lung function test; lysosome; multiple organ failure; myringotomy; nerve cell differentiation; nervous system injury; nuclear magnetic resonance imaging; optic nerve lesion; orthopedic surgery; palliative therapy; phenotype; physical examination; physiotherapy; plasma transfusion; positive end expiratory pressure; priority journal; randomized controlled trial; review; seizure (drug therapy); short stature; side effect (side effect); skeleton malformation (rehabilitation, surgery); spinal cord compression (diagnosis, surgery); stem cell transplantation; terminal care; tooth malformation; tracheotomy; upper respiratory tract obstruction; urticaria (side effect); valvular heart disease; X chromosome linked disorder; 
DRUG TRADE NAMES
  elaprase  , United StatesShire

DRUG MANUFACTURERS
   (United States)Shire
CAS REGISTRY NUMBERS
  adrenalin (51-43-4, 55-31-2, 6912-68-1)
  iduronate 2 sulfatase (50936-59-9)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Developmental Biology and Teratology (21)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009639664
MEDLINE PMID
  19901005 (http://www.ncbi.nlm.nih.gov/pubmed/19901005)
PUI
  L355782836
DOI
  10.1542/peds.2008-0999
FULL TEXT LINK
  http://dx.doi.org/10.1542/peds.2008-0999
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00314005&id=doi:10.1542%2Fpeds.2008-0999&atitle=Multidisciplinary+management+of+Hunter+syndrome&stitle=Pediatrics&title=Pediatrics&volume=124&issue=6&spage=&epage=&aulast=Muenzer&aufirst=Joseph&auinit=J.&aufull=Muenzer+J.&coden=PEDIA&isbn=&pages=-&date=2009&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 760
TITLE
  Delayed homicides and the proximate cause.
AUTHOR NAMES
  Lin P.; Gill J.R.
AUTHOR ADDRESSES
  (Lin P.; Gill J.R.) Department of Forensic Medicine, New York University 
School of Medicine, New York, NY, USA.
CORRESPONDENCE ADDRESS
  P. Lin, Department of Forensic Medicine, New York University School of 
Medicine, New York, NY, USA.
FULL RECORD ENTRY DATE
  2010-03-10
SOURCE
  The American journal of forensic medicine and pathology : official 
publication of the National Association of Medical Examiners (2009) 30:4 
(354-357). Date of Publication: Dec 2009
VOLUME
  30
ISSUE
  4
FIRST PAGE
  354
LAST PAGE
  357
DATE OF PUBLICATION
  Dec 2009
ISSN
  1533-404X (electronic)
ABSTRACT
  Delayed homicides result from complications of remote injuries inflicted by 
"the hands of another." The investigation of delayed homicides may be a 
challenge due to a number of factors including: failure to report the death 
to the proper authorities, lack of ready and adequate documentation of the 
original injury and circumstances, and jurisdictional differences between 
the places of injury and death. The certification of these deaths also 
requires the demonstration of a pathophysiologic link between the remote 
injury and death. In sorting through these issues, it is helpful to rely 
upon the definition of the proximate cause of death. Over a 2-year period in 
New York City, there were 1211 deaths certified as homicide of which 42 were 
due to injuries sustained greater than 1 year before death. The survival 
interval ranged from 1.3 to 43.2 years. The most common immediate causes of 
death were: infections (22), seizures (7), and intestinal 
obstructions/hernias (6). Common patterns of complications included 
infection following a gunshot wound of the spinal cord, seizure disorder due 
to blunt head trauma, and intestinal obstruction/hernia due to adhesions 
from an abdominal stab wound. Spinal cord injuries resulted in paraplegia in 
14 instances and quadriplegia in 8. The mean survival interval for 
paraplegics was 20.3 years and 14.8 years for quadriplegics; infections were 
a frequent immediate cause of death in both groups, particularly infections 
due to chronic bladder catheterization. The definition of proximate cause 
originated with civil law cases and was later applied to death certification 
as the proximate cause of death. The gradual extinction of the "year and a 
day rule" for the limitation of bringing homicide charges in delayed deaths 
may result in more of these deaths going to trial. Medical 
examiners/coroners must be able to explain the reasoning behind these death 
certifications and maintain consistent standards for the certification of 
all delayed deaths due to any injury (homicides, suicides, and accidents).
EMTREE DRUG INDEX TERMS
  anticoagulant agent (adverse drug reaction, drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cause of death; homicide; penetrating trauma (complication, epidemiology); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; bleeding (etiology); catheter infection (etiology); child; death certificate; female; forensic medicine; graft rejection; hernia (etiology); human; infection (etiology); intestine obstruction (etiology); liver transplantation; lung embolism (etiology); male; middle aged; mortality; paraplegia (epidemiology, etiology); quadriplegia (epidemiology, etiology); renal replacement therapy; seizure (etiology); spinal cord injury (epidemiology, etiology); statistics; time; tracheostomy; United States (epidemiology); vein thrombosis (prevention); 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  19901806 (http://www.ncbi.nlm.nih.gov/pubmed/19901806)
PUI
  L355884418
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1533404X&id=doi:&atitle=Delayed+homicides+and+the+proximate+cause.&stitle=Am+J+Forensic+Med+Pathol&title=The+American+journal+of+forensic+medicine+and+pathology+%3A+official+publication+of+the+National+Association+of+Medical+Examiners&volume=30&issue=4&spage=354&epage=357&aulast=Lin&aufirst=Peter&auinit=P.&aufull=Lin+P.&coden=&isbn=&pages=354-357&date=2009&auinit1=P&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 761
TITLE
  Osteoradionecrosis of the cervical spine presenting with quadriplegia in a 
patient previously treated with radiotherapy for laryngeal cancer: A case 
report
AUTHOR NAMES
  Van Wyk F.C.; Sharma M.-P.; Tranter R.
AUTHOR ADDRESSES
  (Van Wyk F.C., fcvanwyk@gmail.com; Sharma M.-P., mpns@doctors.org.uk; 
Tranter R., rtranter@uk-consultants.co.uk) Department of Otolaryngology and 
Head and Neck Surgery, Brighton and Sussex University Hospitals NHS Trust, 
Eastern Road, Brighton, United Kingdom.
CORRESPONDENCE ADDRESS
  F. C. Van Wyk, Department of Otolaryngology and Head and Neck Surgery, 
Brighton and Sussex University Hospitals NHS Trust, Eastern Road, Brighton, 
United Kingdom. Email: fcvanwyk@gmail.com
FULL RECORD ENTRY DATE
  2010-02-16
SOURCE
  Journal of Medical Case Reports (2009) 3 Article Number: 7262. Date of 
Publication: 2009
VOLUME
  3
DATE OF PUBLICATION
  2009
ISSN
  1752-1947
  1752-1947 (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., 34 - 42 Cleveland Street, London, United Kingdom.
ABSTRACT
  Introduction. Osteoradionecrosis of the mandible and temporal bones has been 
extensively reported in literature, but cases of avascular necrosis of the 
cervical spine following radiotherapy to the larynx appear to be extremely 
rare. A review of the English language literature has shown only one other 
case where radiotherapy treatment of a laryngeal carcinoma has resulted in 
osteoradionecrosis of the cervical spine. Case presentation. We present the 
case of a 65 year old male patient who suffered from osteoradionecrosis of 
the cervical spine 20 years after radiotherapy treatment for a T1aN0M0 
laryngeal carcinoma resulting in quadriplegia. Conclusions. Radiotherapy 
carries a long-term risk of complications, including osteoradionecrosis 
which may present 20 years later with significant implications. © 2009 
licensee BioMed Central Ltd.
EMTREE DRUG INDEX TERMS
  analgesic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone necrosis (complication, diagnosis, surgery); cervical spine osteoradionecrosis (complication, diagnosis, surgery); larynx carcinoma (diagnosis, radiotherapy, surgery); quadriplegia (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; article; cancer staging; case report; cellulitis (complication); dizziness; external beam radiotherapy; fibrosis (complication); follow up; histopathology; hoarseness; human; human tissue; laryngeal biopsy; laryngectomy; laryngoscopy; male; neck pain; neurosurgery; nuclear magnetic resonance imaging; paresthesia; priority journal; radiation injury; shoulder pain (drug therapy); spinal cord compression; squamous cell carcinoma (diagnosis, radiotherapy, surgery); tracheostomy; walking difficulty; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Cancer (16)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009650448
PUI
  L355809619
DOI
  10.4076/1752-1947-3-7262
FULL TEXT LINK
  http://dx.doi.org/10.4076/1752-1947-3-7262
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17521947&id=doi:10.4076%2F1752-1947-3-7262&atitle=Osteoradionecrosis+of+the+cervical+spine+presenting+with+quadriplegia+in+a+patient+previously+treated+with+radiotherapy+for+laryngeal+cancer%3A+A+case+report&stitle=J.+Med.+Case+Rep.&title=Journal+of+Medical+Case+Reports&volume=3&issue=&spage=&epage=&aulast=Van+Wyk&aufirst=Frederik+Carl&auinit=F.C.&aufull=Van+Wyk+F.C.&coden=&isbn=&pages=-&date=2009&auinit1=F&auinitm=C
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 762
TITLE
  Tracheostomy timing in traumatic spinal cord injury
AUTHOR NAMES
  Romero J.; Vari A.; Gambarrutta C.; Oliviero A.
AUTHOR ADDRESSES
  (Romero J., fjromero@sescam.jccm.es; Gambarrutta C.; Oliviero A.) Intensive 
Care Unit and Neurology Unit, UCI, Hospital Nacional de Paraplejicos, Finca 
La Peraleda s/n, Toledo 45071, Spain.
(Vari A.) Dipartimento di Anestesia, Rianimazione, Medicina Critica e 
Terapia Del Dolore, Universita la Sapienza, Rome, Italy.
CORRESPONDENCE ADDRESS
  J. Romero, Intensive Care Unit and Neurology Unit, UCI, Hospital Nacional de 
Paraplejicos, Finca La Peraleda s/n, Toledo 45071, Spain. Email: 
fjromero@sescam.jccm.es
FULL RECORD ENTRY DATE
  2009-11-04
SOURCE
  European Spine Journal (2009) 18:10 (1452-1457). Date of Publication: 2009
VOLUME
  18
ISSUE
  10
FIRST PAGE
  1452
LAST PAGE
  1457
DATE OF PUBLICATION
  2009
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  The study conducted is the retrospective study and the main objective is to 
evaluate the benefits and safety of early versus late tracheostomy in 
traumatic spinal cord injury (SCI) patients requiring mechanical 
ventilation. Tracheostomy offers many advantages in critical patients who 
require prolonged mechanical ventilation. Despite the large amount of 
patients treated, there is still an open debate about advantages of early 
versus late tracheostomy. Early tracheostomy following the short orotracheal 
intubation is probably beneficial in appropriately selected patients. It is 
a retrospective clinical study and we evaluated clinical records of 152 
consecutive trauma patients who required mechanical ventilation and who 
received tracheostomy. The results show that the early placement (before day 
7 of mechanical ventilation) offers clear advantages for shortening of 
mechanical ventilation, reducing ICU stay and lowering rates of severe 
orotracheal intubation complication, such as tracheal granulomas and 
concentric tracheal stenosis. On the other hand, we could not demonstrate 
that early tracheostomy avoids neither risk of ventilator-associated 
pneumonia nor the mortality rate. In SCI patients, the early tracheostomy 
was associated with shorter duration of mechanical ventilation, shorter 
length of ICU stay and decreased laryngotracheal complications. We conclude 
by suggesting early tracheostomy in traumatic SCI patients who are likely to 
require prolonged mechanical ventilation. © 2009 Springer-Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; bleeding (complication); controlled study; endotracheal intubation; female; granuloma (complication); hospitalization; human; intensive care unit; logistic regression analysis; major clinical study; male; medical record; mortality; multivariate analysis; pneumonia (complication); priority journal; trachea stenosis (complication); tracheostomy; wound dehiscence (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009539957
MEDLINE PMID
  19655178 (http://www.ncbi.nlm.nih.gov/pubmed/19655178)
PUI
  L50602343
DOI
  10.1007/s00586-009-1097-3
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-009-1097-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-009-1097-3&atitle=Tracheostomy+timing+in+traumatic+spinal+cord+injury&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=18&issue=10&spage=1452&epage=1457&aulast=Romero&aufirst=Javier&auinit=J.&aufull=Romero+J.&coden=ESJOE&isbn=&pages=1452-1457&date=2009&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 763
TITLE
  Placement and complications of cervical pedicle screws in 144 cervical 
trauma patients using pedicle axis view techniques by fluoroscope
AUTHOR NAMES
  Yukawa Y.; Kato F.; Ito K.; Horie Y.; Hida T.; Nakashima H.; MacHino M.
AUTHOR ADDRESSES
  (Yukawa Y., yukawa.ort@chubuh.rofuku.go.jp; Kato F.; Ito K.; Horie Y.; Hida 
T.; Nakashima H.; MacHino M.) Department of Orthopedic Surgery, Chubu Rosai 
Hospital, 1-10-6 Komei, Minato-ku, Nagoya, Aichi 455-0018, Japan.
CORRESPONDENCE ADDRESS
  Y. Yukawa, Department of Orthopedic Surgery, Chubu Rosai Hospital, 1-10-6 
Komei, Minato-ku, Nagoya, Aichi 455-0018, Japan. Email: 
yukawa.ort@chubuh.rofuku.go.jp
FULL RECORD ENTRY DATE
  2009-11-04
SOURCE
  European Spine Journal (2009) 18:9 (1293-1299). Date of Publication: 2009
VOLUME
  18
ISSUE
  9
FIRST PAGE
  1293
LAST PAGE
  1299
DATE OF PUBLICATION
  2009
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Cervical pedicle screw fixation is an effective procedure for stabilising an 
unstable motion segment; however, it has generally been considered too risky 
due to the potential for injury to neurovascular structures, such as the 
spinal cord, nerve roots or vertebral arteries. Since 1995, we have treated 
144 unstable cervical injury patients with pedicle screws using a 
fluoroscopy-assisted pedicle axis view technique. The purpose of this study 
was to investigate the efficacy of this technique in accurately placing 
pedicle screws to treat unstable cervical injuries, and the ensuing clinical 
outcomes and complications. The accuracy of pedicle screw placement was 
postoperatively examined by axial computed tomography scans and oblique 
radiographs. Solid posterior bony fusion without secondary dislodgement was 
accomplished in 96% of all cases. Of the 620 cervical pedicle screws 
inserted, 57 (9.2%) demonstrated screw exposure (<50% of the screw outside 
the pedicle) and 24 (3.9%) demonstrated pedicle perforation (>50% of the 
screw outside the pedicle). There was one case in which a probe penetrated a 
vertebral artery without further complication and one case with transient 
radiculopathy. Pre- and postoperative tracheotomy was required in 20 (13.9%) 
of the 144 patients. However, the tracheotomies were easily performed, 
because those patients underwent posterior surgery alone without 
postoperative external fixation. The placement of cervical pedicle screws 
using a fluoroscopy-assisted pedicle axis view technique provided good 
clinical results and a few complications for unstable cervical injuries, but 
a careful surgical procedure was needed to safely insert the screws and more 
improvement in imaging and navigation system is expected. © 2009 
Springer-Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; pedicle screw; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; bone radiography; computer assisted tomography; controlled study; female; fluoroscopy; fracture fixation; human; major clinical study; male; postoperative complication; priority journal; radiculopathy (complication); tracheotomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009526547
MEDLINE PMID
  19488794 (http://www.ncbi.nlm.nih.gov/pubmed/19488794)
PUI
  L50538548
DOI
  10.1007/s00586-009-1032-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-009-1032-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-009-1032-7&atitle=Placement+and+complications+of+cervical+pedicle+screws+in+144+cervical+trauma+patients+using+pedicle+axis+view+techniques+by+fluoroscope&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=18&issue=9&spage=1293&epage=1299&aulast=Yukawa&aufirst=Yasutsugu&auinit=Y.&aufull=Yukawa+Y.&coden=ESJOE&isbn=&pages=1293-1299&date=2009&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 764
TITLE
  Circumferential fixation with craniofacial miniplates for a cervical spine 
injury in a child: Case report
AUTHOR NAMES
  Patel N.B.; Hazzard M.A.; Ackerman L.L.; Horn E.M.
AUTHOR ADDRESSES
  (Patel N.B.; Hazzard M.A.; Ackerman L.L.; Horn E.M., emhorn@iupui.edu) 
Department of Neurological Surgery, Indiana University School of Medicine, 
139 Emerson Hall, 545 Barnhill Drive, Indianapolis, IN 46202-5124, United 
States.
CORRESPONDENCE ADDRESS
  E. M. Horn, Department of Neurological Surgery, Indiana University School of 
Medicine, 139 Emerson Hall, 545 Barnhill Drive, Indianapolis, IN 46202-5124, 
United States. Email: emhorn@iupui.edu
FULL RECORD ENTRY DATE
  2009-12-30
SOURCE
  Journal of Neurosurgery: Pediatrics (2009) 4:5 (429-433). Date of 
Publication: November 2009
VOLUME
  4
ISSUE
  5
FIRST PAGE
  429
LAST PAGE
  433
DATE OF PUBLICATION
  November 2009
ISSN
  1933-0707
  1933-0715 (electronic)
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Unstable pediatric cervical spine injuries present significant challenges in 
terms of fixation. Given the smaller cervical vertebral bodies in the 
preschool-aged population, commercially available pediatric cervical 
fixation instrumentation may be unsuitable because of the inappropriately 
large size of the screws and plates. The authors describe a 2-year-old girl 
who sustained an unstable C6-7 distraction injury during a motor vehicle 
accident. Because of the small size of her vertebral bodies, standard 
cervical spine instrumentation was not feasible, and posterior wiring alone 
was believed to be insufficient because of the complete distraction of all 3 
spinal columns. The patient was taken to the operating room where 
craniofacial plates with an inherent locking mechanism were used to 
circumferentially stabilize the cervical spine. Follow-up examination 6 
months postoperatively demonstrated stable cervical spine alignment and 
fusion with no evidence of the failure of either the anterior or posterior 
hardware. The use of craniofacial miniplates with an intrinsic locking 
mechanism represents a superior alternative for both anterior and posterior 
cervical fixations when spinal instrumentation is needed in the pediatric 
age group.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone plate; cervical spine injury (surgery); plate fixation; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; case report; cervical spine radiography; child; computed tomographic angiography; feeding apparatus; female; follow up; general anesthesia; hospital discharge; human; interlocking nail; intubation; lung contusion; neck; neurologic examination; nuclear magnetic resonance imaging; operating room; postoperative period; preschool child; priority journal; spine fusion; spine stabilization; suture; tracheostomy; traffic accident; vertebra body; vertebral artery; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009597756
MEDLINE PMID
  19877774 (http://www.ncbi.nlm.nih.gov/pubmed/19877774)
PUI
  L355654329
DOI
  10.3171/2009.6.PEDS0913
FULL TEXT LINK
  http://dx.doi.org/10.3171/2009.6.PEDS0913
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19330707&id=doi:10.3171%2F2009.6.PEDS0913&atitle=Circumferential+fixation+with+craniofacial+miniplates+for+a+cervical+spine+injury+in+a+child%3A+Case+report&stitle=J.+Neursurg.+Pediatr.&title=Journal+of+Neurosurgery%3A+Pediatrics&volume=4&issue=5&spage=429&epage=433&aulast=Patel&aufirst=Neal+B.&auinit=N.B.&aufull=Patel+N.B.&coden=&isbn=&pages=429-433&date=2009&auinit1=N&auinitm=B
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 765
TITLE
  Concomitant distal aortic perfusion and passage of a retrograde aortic 
occlusion balloon for complex aortic operations
AUTHOR NAMES
  Watson D.; Barbosa R.; Ansel G.
AUTHOR ADDRESSES
  (Watson D.; Barbosa R.; Ansel G.) Riverside Methodist Hospital, Columbus, 
United States.
CORRESPONDENCE ADDRESS
  D. Watson, Riverside Methodist Hospital, Columbus, United States.
FULL RECORD ENTRY DATE
  2010-03-26
SOURCE
  Interactive Cardiovascular and Thoracic Surgery (2009) 9 SUPPL. 2 (S92). 
Date of Publication: October 2009
VOLUME
  9
FIRST PAGE
  S92
DATE OF PUBLICATION
  October 2009
CONFERENCE NAME
  23rd Annual Meeting of the European Association for Cardio-Thoracic Surgery
CONFERENCE LOCATION
  Vienna, Austria
CONFERENCE DATE
  2009-10-17 to 2009-10-21
ISSN
  1569-9293
BOOK PUBLISHER
  European Association for Cardio-Thoracic Surgery
ABSTRACT
  Objectives: We investigated a unique method utilising a Heartport bifurcated 
arterial cannula and a compliant aortic occlusion balloon (CODA, Cook, Inc.) 
to provide both distal perfusion and provide bloodless distal arterial 
occlusion in thoraco-abdominal aneurysm repair. Methods: Between February 
2002 and September 2008, 21 patients (4 urgent, 17 elective) underwent 
thoracic or thoracoabdominal aortic repair with this method. Due to an 
inability or potential difficulty in gaining distal aortic control because 
of anatomic or technical difficulty, a CODA balloon was passed through the 
accessory arterial channel using fluoroscopic guidance. Adjunctive 
cerebrospinal drainage was used in all cases. Results: Balloon deployment 
and satisfactory occlusion was attained in all cases. The overall 30-day 
mortality rate was 9%. Among urgent patients, the mortality rate was 50% vs. 
0% for elective patients. Renal failure occurred in 9% of cases. Six 
patients (28%) had pulmonary complications. Transient encephalopathy 
occurred in two patients. Spinal cord neurologic deficit and stroke were 
avoided in all patients. There was no incidence of significant arterial 
injury, although one patient required femoral patch arterioplasty at the 
completion of decannulation. Conclusions: Distal aortic perfusion and 
passage of a retrograde aortic occlusion balloon did not increase the 
incidence of death and morbidity to a greater rate than with conventional 
methods of distal aortic control. We recommend the application of this 
method to maintain ongoing distal aortic perfusion in instances where distal 
control with a clamp is not feasible or creates the potential for 
catastrophic intraoperative bleeding.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic occlusion; balloon occlusion; perfusion; thorax surgery; 
EMTREE MEDICAL INDEX TERMS
  aneurysm; aortic reconstruction; artery injury; artery occlusion; artery reconstruction; bleeding; brain disease; cannula; cerebrovascular accident; clamp; death; kidney failure; morbidity; mortality; occlusion; patient; spinal cord; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70082360
DOI
  10.1510/icvts.2009.0000S7
FULL TEXT LINK
  http://dx.doi.org/10.1510/icvts.2009.0000S7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15699293&id=doi:10.1510%2Ficvts.2009.0000S7&atitle=Concomitant+distal+aortic+perfusion+and+passage+of+a+retrograde+aortic+occlusion+balloon+for+complex+aortic+operations&stitle=Interact.+Cardiovasc.+Thorac.+Surg.&title=Interactive+Cardiovascular+and+Thoracic+Surgery&volume=9&issue=&spage=S92&epage=&aulast=Watson&aufirst=D.&auinit=D.&aufull=Watson+D.&coden=&isbn=&pages=S92-&date=2009&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 766
TITLE
  Apnea and macrocephaly-cutis marmorata telangiectatica congenita
AUTHOR NAMES
  Franklin B.; Gasco J.; Rangel-Castilla L.; Nauta H.J.W.
AUTHOR ADDRESSES
  (Franklin B.; Gasco J., jagascot@utmb.edu; Rangel-Castilla L.; Nauta H.J.W.) 
University of Texas Medical Branch, Division of Neurosurgery, 301 University 
Boulevard, John Sealy Annex, Galveston, TX 77555, United States.
CORRESPONDENCE ADDRESS
  J. Gasco, University of Texas Medical Branch, Division of Neurosurgery, 301 
University Boulevard, John Sealy Annex, Galveston, TX 77555, United States. 
Email: jagascot@utmb.edu
FULL RECORD ENTRY DATE
  2009-10-15
SOURCE
  Brain and Development (2009) 31:9 (706-709). Date of Publication: October 
2009
VOLUME
  31
ISSUE
  9
FIRST PAGE
  706
LAST PAGE
  709
DATE OF PUBLICATION
  October 2009
ISSN
  0387-7604
BOOK PUBLISHER
  Elsevier, P.O. Box 211, Amsterdam, Netherlands.
ABSTRACT
  The authors report a case of an infant girl with macrocephaly-cutis 
marmorata telangiectatica congenita (Macrocephaly-CMTC). This patient 
presented with developmental delay, mild subcostal retractions, and 
occasional apneic spells. An MRI demonstrated mild to moderate lateral 
ventricle hydrocephalus, left hemi-megalencephaly, and left cerebellar 
tonsillar herniation with full occlusion of the cisterna magna. Her foramen 
magnum was narrowed, measuring 17.5 mm in transverse diameter. This value 
was significantly below the 50th percentile for age, which is 23.5 mm. 
Together, these findings were suggestive of cervicomedullary cord 
compression, concerning for sudden death. The patient underwent posterior 
fossa decompression by suboccipital craniectomy and cervical laminectomy. 
Initially due to hypertrophy and paralysis of the left true and false vocal 
cords, endotracheal intubation was not achieved, requiring tracheostomy tube 
placement. To our knowledge this is the first report of apnea in a patient 
diagnosed with M-CMTC, likely due to cervicomedullary cord compression and 
perhaps exacerbated by unilateral laryngeal hypertrophy. M-CMTC is a 
newly-described hemi-hypertrophy syndrome affecting the neurodevelopment of 
affected children. The authors emphasize airway obstruction secondary to 
unilateral hypertrophy of the vocal cords in addition to brainstem 
compromise as a consideration for the etiology of apnea in M-CMTC patients 
presenting with signs and symptoms of cervicomedullary cord compression. © 
2008 Elsevier B.V. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  apnea (diagnosis); cutis marmorata telangiectatica congenita (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  Alexander disease; article; brain hernia; case report; craniectomy; female; human; hydrocephalus (surgery); infant; laminectomy; nuclear magnetic resonance imaging; physical examination; spinal cord compression (surgery); sudden death; tracheostomy; vocal cord paralysis; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Dermatology and Venereology (13)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009450568
MEDLINE PMID
  19041204 (http://www.ncbi.nlm.nih.gov/pubmed/19041204)
PUI
  L50345041
DOI
  10.1016/j.braindev.2008.10.006
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.braindev.2008.10.006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03877604&id=doi:10.1016%2Fj.braindev.2008.10.006&atitle=Apnea+and+macrocephaly-cutis+marmorata+telangiectatica+congenita&stitle=Brain+Dev.&title=Brain+and+Development&volume=31&issue=9&spage=706&epage=709&aulast=Franklin&aufirst=Brodus&auinit=B.&aufull=Franklin+B.&coden=BDEVD&isbn=&pages=706-709&date=2009&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 767
TITLE
  Critical care after major trauma: We need to think beyond the unit
AUTHOR NAMES
  Lavery G.G.; Bhavsar M.
AUTHOR ADDRESSES
  (Lavery G.G., gavin.lavery@belfasttrust.hscni.net; Bhavsar M.) Regional 
Intensive Care Unit, Royal Hospitals, Belfast HSC Trust, Belfast, United 
Kingdom.
CORRESPONDENCE ADDRESS
  G. G. Lavery, Regional Intensive Care Unit, Royal Hospitals, Belfast HSC 
Trust, Belfast, United Kingdom. Email: gavin.lavery@belfasttrust.hscni.net
FULL RECORD ENTRY DATE
  2010-01-15
SOURCE
  British Journal of Intensive Care (2009) 19:3 (87-94). Date of Publication: 
Autumn 2009
VOLUME
  19
ISSUE
  3
FIRST PAGE
  87
LAST PAGE
  94
DATE OF PUBLICATION
  Autumn 2009
ISSN
  0961-7930
BOOK PUBLISHER
  Greycoat Publishing, 120 Dawes Road, London, United Kingdom.
ABSTRACT
  To facilitate the delivery of best care to the victim of major trauma, 
intensivists need to have knowledge in areas beyond the boundaries of 
mainstream critical care. Early in trauma care, key decisions regarding the 
need for damage control surgery should be made with input from critical care 
staff. The major trauma victim should have a tertiary trauma assessment to 
reduce the risk of missed injuries. The management of patients with 
potential spinal instability should reflect that prolonged immobilisation, 
while possibly reducing the risk of worsening neurological damage, is also a 
significant safety risk. Appropriate use of imaging should ensure very few 
patients, without demonstrable spinal injury, have spinal precautions in 
force for more than 48-72 hrs. Knowledge of compartment syndromes (extremity 
and abdominal) will assist in the early recognition and management of these 
conditions. Issues such as, 1) long-term management of patients with 
tracheostomy and 2) the potential for rehabilitation should be addressed as 
part of the critical care treatment plan for the trauma patent.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care unit; spine injury (rehabilitation, surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal compartment syndrome (complication, rehabilitation, surgery); chronic obstructive lung disease (complication, rehabilitation); clinical assessment; compartment syndrome (complication, rehabilitation, surgery); exercise tolerance; follow up; health care management; health care personnel; human; immobilization; laparotomy; limb; long term care; medical decision making; nervous system injury; patient care; patient safety; quality of life; review; risk; spine instability; tracheostomy; treatment planning; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009643007
PUI
  L355792487
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09617930&id=doi:&atitle=Critical+care+after+major+trauma%3A+We+need+to+think+beyond+the+unit&stitle=Br.+J.+Intensive+Care&title=British+Journal+of+Intensive+Care&volume=19&issue=3&spage=87&epage=94&aulast=Lavery&aufirst=G.G.&auinit=G.G.&aufull=Lavery+G.G.&coden=BJICE&isbn=&pages=87-94&date=2009&auinit1=G&auinitm=G
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 768
TITLE
  Chiari-I “Benign but not so Benig” - A clinical case
AUTHOR NAMES
  Vora N.; Steers A.J.W.; Verity K.; Baxter A.; McLellan A.E.
AUTHOR ADDRESSES
  (Vora N.; Steers A.J.W.; Verity K.; Baxter A.; McLellan A.E.) Neurosciences 
Department, Royal Hospital for Sick Children, Edinburgh, United Kingdom.
CORRESPONDENCE ADDRESS
  N. Vora, Neurosciences Department, Royal Hospital for Sick Children, 
Edinburgh, United Kingdom.
FULL RECORD ENTRY DATE
  2010-07-13
SOURCE
  European Journal of Paediatric Neurology (2009) 13 SUPPL. 1 (S27). Date of 
Publication: September 2009
VOLUME
  13
FIRST PAGE
  S27
DATE OF PUBLICATION
  September 2009
CONFERENCE NAME
  8th Congress of the European Paediatric Society, EPNS 2009
CONFERENCE LOCATION
  Harrogate, United Kingdom
CONFERENCE DATE
  2009-09-30 to 2009-10-03
ISSN
  1090-3798
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Introduction: Chiari-I malformation is often asymptomatic and found 
incidentally on neuroimaging. This case highlights a rare and devastating 
complication of the condition. Case History: A previously well 13year girl 
with normal development presented to local hospital with 4 days history of 
cough, cold, left ear pain and ear discharge. She had headache, neck 
stiffness, vomitting, high temperature and was confused. She was thought to 
have meningitis and appropriate management was started. Two hours after 
admission she had an acute episode of tonic posturing, desaturation and 
apnoea. She was intubated for ventilation. On examination she was making no 
respiratory effort and had no spontaneous movement. Her pupils were reactive 
and eye movements intact. Investigations revealed elevated inflammatory 
markers. Blood and CSF PCRs negative for routine bacterial and viral 
pathology. CT Brain showed herniation of cerebellar tonsils through foramen 
magnum. MRI Brain revealed bilateral cerebellar infarcts, herniation of 
cerebellar tonsils through foramen magnum, consistent with coning and upper 
cervical cord and lower brain stem ischemia in the territory of PICA In an 
attempt to prevent further cord ischaemia she had a posterior 
cranio-vertebral decompression to C3 and resection of infracted cerebellum 
and cerebellar tonsils. She remains ventilated via a tracheostomy and 
undergoing Neurorehabilitation. Neuropsychology assessment demonstrated 
intact cognitive function. Discussion: She had an underlying Chiari-I 
malformation and coincidental acute otitic inflammatory process produced 
vascular changes and swelling within the posterior fossa and foraminal 
impaction which led to an increasingly severe ischemia, resulting in 
cerebellar infarction and infarction of lower medulla and upper end of 
cervical spinal cord. Chiari-I is thought to be benign and if asymptomatic 
should not require treatment but very rarely it can lead to life threatening 
brainstem coning. Chiari-I is generally a benign condition but not so benign 
in this case.
EMTREE DRUG INDEX TERMS
  marker; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  society; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; apnea; Arnold Chiari malformation; blood; brain; brain stem; cerebellum; cerebellum infarction; cerebrospinal fluid; cervical spinal cord; cognition; coughing; decompression; development; ear; examination; eye movement; fatty acid desaturation; foramen magnum; girl; headache; hernia; high temperature; hospital; infarction; inflammation; ischemia; meningitis; neck; neuroimaging; neuropsychology; nuclear magnetic resonance imaging; otalgia; pathology; posterior fossa; rigidity; surgery; swelling; tonsil; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70189820
DOI
  10.1016/S1090-3798(09)70078-9
FULL TEXT LINK
  http://dx.doi.org/10.1016/S1090-3798(09)70078-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10903798&id=doi:10.1016%2FS1090-3798%2809%2970078-9&atitle=Chiari-I+%E2%80%9CBenign+but+not+so+Benig%E2%80%9D+-+A+clinical+case&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=13&issue=&spage=S27&epage=&aulast=Vora&aufirst=N.&auinit=N.&aufull=Vora+N.&coden=&isbn=&pages=S27-&date=2009&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 769
TITLE
  Coexistence of Guillain-Barre syndrome and ADEM in patient with ovarium 
teratoma-case report
AUTHOR NAMES
  Dunin-Wasowicz D.; Jurkiewicz E.; Jozwiak S.
AUTHOR ADDRESSES
  (Dunin-Wasowicz D.; Jozwiak S.) Neurology and Epileptology Department, 
Children's Memorial Health Institute, Warsaw, Poland.
(Jurkiewicz E.) Department of Imaging Diagnostics, Children's Memorial 
Health Institute, Warsaw, Poland.
CORRESPONDENCE ADDRESS
  D. Dunin-Wasowicz, Neurology and Epileptology Department, Children's 
Memorial Health Institute, Warsaw, Poland.
FULL RECORD ENTRY DATE
  2010-07-13
SOURCE
  European Journal of Paediatric Neurology (2009) 13 SUPPL. 1 (S45-S46). Date 
of Publication: September 2009
VOLUME
  13
FIRST PAGE
  S45
LAST PAGE
  S46
DATE OF PUBLICATION
  September 2009
CONFERENCE NAME
  8th Congress of the European Paediatric Society, EPNS 2009
CONFERENCE LOCATION
  Harrogate, United Kingdom
CONFERENCE DATE
  2009-09-30 to 2009-10-03
ISSN
  1090-3798
BOOK PUBLISHER
  W.B. Saunders Ltd
ABSTRACT
  Objective: Neuroimmunological diseases are not rare in children however, 
coexistence Guillain-Barre syndrome (GBS) and ADEM is unusual. Methods: 
description of the clinical symptoms and signs, examinations results, 
treatment and follow-up of the patient. Results: 14 year old girl was 
admitted to our Department with sudden weakness of lower limbs, swallowing 
and superficial sensibility disturbances in legs and arms. She suffered from 
the upper respiratory tract infection without fever for a few days, before 
the onset of the neurological symptoms and signs. Neurological examination 
displayed flaccid paresis of all limbs without deep tendon reflexes, 
swallowing and superficial sensibility disturbances, weak pharyngeal reflex, 
silent speech and dyspnoea enabling diagnosis of GBS. Only few hours later 
respiratory failure with consciousness disturbances and anisocoria occurred 
and she was admitted to the Intensive Care Unit. At that moment MRI brain 
scans were normal, as well as the one repeated during the second week of the 
disease. She was treated with artificial ventilation, plasmaferesis (11), 
immunoglobulins, different steroids, antibiotics, antifungal drugs and 
rehabilitation. Tracheostomy was also necessary. Three weeks after the onset 
of the neurological symptoms, brain MRI revealed hypodensic cotrical and 
subcortical changes in the white matter in both cerebral and cerebellar 
heminspheres, and spinal cord MRI was normal(ADEM). No response was found in 
the motor and sensory fibres in NCS examination. BAEP was abnormal with left 
side lateralization and EEG featured brain oedema. Lumbar puncture was 
unsuccessful (mother disagreed). After two months, brain MRI revealed 
regression of the changes and NCS examination presented features of 
axonal-demyelinating neuropathy. All virological tests and bacterial 
cultures were negative. The patient presented high hypercalcemia. After five 
months from the onset of the disease, resection of teratoma in both ovaries 
was performed. The girl recovered without any disabilities. Conclusion: We 
diagnosed severe paraneoplastic syndrome.
EMTREE DRUG INDEX TERMS
  antifungal agent; immunoglobulin; steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  case report; Guillain Barre syndrome; hospital patient; ovary; society; teratoma; 
EMTREE MEDICAL INDEX TERMS
  anisocoria; arm; artificial ventilation; bacterium culture; brain; brain scintiscanning; child; consciousness; demyelinating neuropathy; diagnosis; disability; dyspnea; edema; electroencephalogram; examination; fever; fiber; flaccid paralysis; follow up; girl; hypercalcemia; intensive care unit; leg; limb; lumbar puncture; mother; neurologic disease; neurologic examination; nuclear magnetic resonance imaging; paraneoplastic syndrome; patient; reflex; rehabilitation; respiratory failure; sensibility; speech; spinal cord; surgery; swallowing; tendon reflex; tracheostomy; upper respiratory tract infection; weakness; white matter; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70189880
DOI
  10.1016/S1090-3798(09)70139-4
FULL TEXT LINK
  http://dx.doi.org/10.1016/S1090-3798(09)70139-4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10903798&id=doi:10.1016%2FS1090-3798%2809%2970139-4&atitle=Coexistence+of+Guillain-Barre+syndrome+and+ADEM+in+patient+with+ovarium+teratoma-case+report&stitle=Eur.+J.+Paediatr.+Neurol.&title=European+Journal+of+Paediatric+Neurology&volume=13&issue=&spage=S45&epage=S46&aulast=Dunin-Wasowicz&aufirst=D.&auinit=D.&aufull=Dunin-Wasowicz+D.&coden=&isbn=&pages=S45-S46&date=2009&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 770
TITLE
  Airway management in patients with facial trauma
AUTHOR NAMES
  Mohan R.; Iyer R.; Thaller S.
AUTHOR ADDRESSES
  (Mohan R.; Iyer R.; Thaller S., sthaller@med.miami.edu) Division of Plastic, 
Reconstructive, and Aesthetic Surgery, Miller School of Medicine, University 
of Miami, Miami, FL.
(Thaller S., sthaller@med.miami.edu) Division of Plastic, Reconstructive, 
and Aesthetic Surgery, University of Miami, Miller School of Medicine/JMH, 
PO Box 016960, Miami, FL 33101.
CORRESPONDENCE ADDRESS
  S. Thaller, Division of Plastic, Reconstructive, and Aesthetic Surgery, 
University of Miami, Miller School of Medicine/JMH, PO Box 016960, Miami, FL 
33101. Email: sthaller@med.miami.edu
FULL RECORD ENTRY DATE
  2009-08-12
SOURCE
  Journal of Craniofacial Surgery (2009) 20:1 (21-23). Date of Publication: 
2009
VOLUME
  20
ISSUE
  1
FIRST PAGE
  21
LAST PAGE
  23
DATE OF PUBLICATION
  2009
ISSN
  1049-2275
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Management of the airway is a major concern in patients with maxillofacial 
trauma (gunshot wounds, facial fractures, cervical spine injuries, 
laryngotracheal injuries) because a compromised airway can lead to death. 
The method of intubation to use in these patients remains a controversial 
topic. Although there are many options available, each one has specific 
indications, and the choice will ultimately depend on the patient's 
situation and the expertise of the trauma team. In general, endotracheal 
intubation is usually not a viable option, but nasotracheal intubation and 
tracheotomies can be performed. Yet, these 2 procedures are known to also 
have complications. Two interesting alternatives that can be opted for are 
the submental and submandibular intubation techniques. © 2009 Mutaz B. 
Habal, MD.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway; maxillofacial injury; 
EMTREE MEDICAL INDEX TERMS
  aerophagia (complication); airway obstruction (complication); article; atelectasis (complication); bleeding; cervical spine injury; death; dysphagia (complication); edema (complication); emergency surgery; endotracheal intubation; face fracture; gunshot injury; human; hypotension (complication); infection (complication); keloid (complication); laryngeal nerve; larynx injury; long term care; lung clearance; lung hemorrhage (complication); nasotracheal intubation; nerve injury (complication); pneumonia (complication); priority journal; subcutaneous emphysema (complication); trachea injury; trachea stenosis (complication); tracheoesophageal fistula (complication); tracheotomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009344649
MEDLINE PMID
  19164982 (http://www.ncbi.nlm.nih.gov/pubmed/19164982)
PUI
  L354886580
DOI
  10.1097/SCS.0b013e318190327a
FULL TEXT LINK
  http://dx.doi.org/10.1097/SCS.0b013e318190327a
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10492275&id=doi:10.1097%2FSCS.0b013e318190327a&atitle=Airway+management+in+patients+with+facial+trauma&stitle=J.+Craniofac.+Surg.&title=Journal+of+Craniofacial+Surgery&volume=20&issue=1&spage=21&epage=23&aulast=Mohan&aufirst=Raja&auinit=R.&aufull=Mohan+R.&coden=JSURE&isbn=&pages=21-23&date=2009&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 771
TITLE
  External Control of Exhalation for Cough Assistance: A Method for Patients 
With Glottis Dysfunction and/or Tracheostomy
AUTHOR NAMES
  Lee S.C.; Park J.H.; Kang S.-W.; Kim D.H.; Song S.H.
AUTHOR ADDRESSES
  (Lee S.C.) Department of Physical Medicine and Rehabilitation, Myongji 
Hospital, Kwandong University College of Medicine, Koyang, Kyunggi, South 
Korea.
(Park J.H.; Kang S.-W., kswoong@yuhs.ac; Kim D.H.) Department of 
Rehabilitation Medicine, Rehabilitation Institute of Muscular Disease, 
Yonsei University College of Medicine, Seoul, South Korea.
(Song S.H.) Department of Biomedical Engineering, Graduate School, Yonsei 
University, Seoul, South Korea.
CORRESPONDENCE ADDRESS
  S.-W. Kang, Department of Rehabilitation Medicine, Rehabilitation Institute 
of Muscular Disease, Yonsei University College of Medicine, Seoul, South 
Korea. Email: kswoong@yuhs.ac
FULL RECORD ENTRY DATE
  2009-08-27
SOURCE
  Archives of Physical Medicine and Rehabilitation (2009) 90:8 (1402-1407). 
Date of Publication: August 2009
VOLUME
  90
ISSUE
  8
FIRST PAGE
  1402
LAST PAGE
  1407
DATE OF PUBLICATION
  August 2009
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Lee SC, Park JH, Kang S-W, Kim DH, Song SH. External control of exhalation 
for cough assistance: a method for patients with glottis dysfunction and/or 
tracheostomy. Objective: To investigate the effectiveness of our method of 
assisting a cough by mimicking the functions of the glottis in patients with 
bulbar muscle weakness or paralysis and/or those who had a tracheostomy 
tube. Design: Before-after trial. Setting: University rehabilitation 
hospital. Participants: Patients (N=35) with bulbar muscle weakness or 
paralysis and/or those who had a tracheostomy tube. Interventions: Not 
applicable. Main Outcome Measures: The unassisted peak cough flow (PCF), the 
assisted PCF, and the assisted PCF with the external control method 
mimicking glottis function by an end-inspiratory external closure of the 
airways. Results: Of the 35 patients, 13 were tracheostomized cervical cord 
injury patients, 11 were neuromuscular disease (NMD) patients with glottis 
dysfunction only, and 11 were NMD patients with a tracheostomy and glottis 
dysfunction. Assisted PCF with the external control method were higher than 
unassisted PCF and/or assisted PCF in all patients. Assisted PCF with the 
external control methods were measured in all of the patients even when the 
unassisted PCFs and/or assisted PCFs could not be measured. For patients 
with measurable assisted PCFs, the assisted PCF with the external control 
methods were significantly higher than the assisted PCFs. Conclusions: We 
showed the effectiveness of our method of assisting a cough by external 
control of the glottis in patients with bulbar muscle weakness or paralysis 
and/or those who had a tracheostomy tube who cannot effectively cough with 
the help of existing cough assistance methods. © 2009 American Congress of 
Rehabilitation Medicine.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bulbar paralysis; coughing; glottis; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cervical spinal cord injury; clinical article; exhalation; female; human; larynx disorder; male; neuromuscular disease; peak expiratory flow; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009395958
MEDLINE PMID
  19651275 (http://www.ncbi.nlm.nih.gov/pubmed/19651275)
PUI
  L355014893
DOI
  10.1016/j.apmr.2009.02.017
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2009.02.017
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2Fj.apmr.2009.02.017&atitle=External+Control+of+Exhalation+for+Cough+Assistance%3A+A+Method+for+Patients+With+Glottis+Dysfunction+and%2For+Tracheostomy&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=90&issue=8&spage=1402&epage=1407&aulast=Lee&aufirst=Sang+Chul&auinit=S.C.&aufull=Lee+S.C.&coden=APMHA&isbn=&pages=1402-1407&date=2009&auinit1=S&auinitm=C
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 772
TITLE
  Posttraumatic tracheal stenosis after complex fracture of the upper cervical 
spine : A rare complication
ORIGINAL (NON-ENGLISH) TITLE
  Posttraumatische Trachealstenose nach komplexer HWS-Fraktur : Eine seltene 
Komplikation
AUTHOR NAMES
  Dudda M.; Frangen T.M.; Muhr G.; Schinkel C.
AUTHOR ADDRESSES
  (Dudda M., Marcel.Dudda@ruhr-uni-bochum.de; Frangen T.M.; Muhr G.; Schinkel 
C.) Chirurgische Klinik und Poliklinik, BG Universitätsklinikum 
Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, Bochum, 
Germany.
CORRESPONDENCE ADDRESS
  M. Dudda, Chirurgische Klinik und Poliklinik, BG Universitätsklinikum 
Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, Bochum, 
Germany. Email: Marcel.Dudda@ruhr-uni-bochum.de
FULL RECORD ENTRY DATE
  2010-04-01
SOURCE
  Unfallchirurg (2009) 112:8 (734-737). Date of Publication: August 2009
VOLUME
  112
ISSUE
  8
FIRST PAGE
  734
LAST PAGE
  737
DATE OF PUBLICATION
  August 2009
ISSN
  0177-5537
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Combined injuries of the upper cervical spine are rare and can lead to 
life-threatening positional changes of the respiratory tract. Hence, it is 
very important to recognize tracheal and soft tissue injuries and to treat 
these adequately. We report on the clinical course and outcome of a case 
with a delayed high-grade tracheal stenosis after cervical spine injury, 
which could only be treated by emergency tracheotomy and partial transverse 
trachea resection.The 25-year-old female suffered a complex dislocated upper 
cervical spine fracture with a Jefferson fracture, an odontoid fracture and 
a dislocated C6/7 luxation fracture after a motor vehicle accident. 
Immediately after trauma inspiratory stridor was reported. Postoperatively, 
the tracheal stenosis increased and the histological examination of tissue 
collected during emergency bronchoscopy showed granulation tissue.Even if 
fractures of cervical spine injuries are treated successfully, soft tissue 
and tracheal injuries cannot be precluded. Therefore, it is most important 
that such patients are followed-up closely to classify the problem and to 
determine the ideal time for surgical treatment of tracheal injuries and 
stenoses. © 2009 Springer Medizin Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture (surgery); trachea stenosis (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; bronchoscopy; case report; female; granulation tissue (diagnosis); histopathology; human; human tissue; odontoid process fracture; stridor; trachea resection; tracheotomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  2009452607
MEDLINE PMID
  19440677 (http://www.ncbi.nlm.nih.gov/pubmed/19440677)
PUI
  L50509684
DOI
  10.1007/s00113-009-1625-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00113-009-1625-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01775537&id=doi:10.1007%2Fs00113-009-1625-y&atitle=Posttraumatic+tracheal+stenosis+after+complex+fracture+of+the+upper+cervical+spine+%3A+A+rare+complication&stitle=Unfallchirurg&title=Unfallchirurg&volume=112&issue=8&spage=734&epage=737&aulast=Dudda&aufirst=M.&auinit=M.&aufull=Dudda+M.&coden=UNFAE&isbn=&pages=734-737&date=2009&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 773
TITLE
  Experimental study of a late response recorded from the thoracic wall after 
phrenic nerve stimulation
AUTHOR NAMES
  Rouaud T.; Magot A.; Guihéneuc P.; Perrouin Verbe B.; Truffert A.; Péréon Y.
AUTHOR ADDRESSES
  (Rouaud T.; Magot A.; Guihéneuc P.; Péréon Y., Yann.Pereon@univ-nantes.fr) 
CHU Nantes, Laboratoire d'Explorations Fonctionnelles, Nantes, France.
(Magot A.; Péréon Y., Yann.Pereon@univ-nantes.fr) CHU Nantes, Centre de 
Référence Maladies Neuromusculaires Rares Nantes Angers, Nantes, France.
(Magot A.; Péréon Y., Yann.Pereon@univ-nantes.fr) Inserm UMR 915, Université 
de Nantes, France.
(Perrouin Verbe B.) CHU Nantes, Service de Médecine Physique et 
Réhabilitation, Nantes, France.
(Truffert A.) Clinique de Neurologie, Unité ENMG et des Affections 
Neuromusculaires, Hôpital Cantonal Universitaire, Geneva, Switzerland.
CORRESPONDENCE ADDRESS
  Y. Péréon, CHU Nantes, Laboratoire d'Explorations Fonctionnelles, Nantes, 
France. Email: Yann.Pereon@univ-nantes.fr
FULL RECORD ENTRY DATE
  2009-09-21
SOURCE
  Clinical Neurophysiology (2009) 120:8 (1543-1547). Date of Publication: 
August 2009
VOLUME
  120
ISSUE
  8
FIRST PAGE
  1543
LAST PAGE
  1547
DATE OF PUBLICATION
  August 2009
ISSN
  1388-2457
BOOK PUBLISHER
  Elsevier Ireland Ltd, P.O. Box 85, Limerick, Ireland.
ABSTRACT
  Objectives: The phrenic nerve cervical stimulation induces an early motor 
diaphragmatic M response that may be recorded from the 7th ipsilateral 
intercostal space (ICS). Some responses with prolonged latency and of 
unclear origin can be recorded from the same recording site. The aim of the 
study was to determine the electrophysiological characteristics and the 
neuroanatomical pathways underlying the long-latency responses (LLRs) 
recorded from the 7th ICS. Methods: We studied seven healthy volunteers, 
five patients with spinal cord injury and five patients with diaphragmatic 
palsy. All underwent phrenic nerve conduction study. An LLR was sought for 
at different stimulation sites using various stimulus intensities. Results: 
A polyphasic LLR was recorded from the 7th ICS in all healthy subjects. It 
was mainly elicited by nociceptive stimulations, not only of the phrenic, 
but also of the median nerves. Its latency was longer than 70 ms, with a 
wide inter- and intra-individual variability. Amplitude was highly variable 
and some habituation phenomenon occurred. The LLR was retained in most 
tetraplegic patients after phrenic nerve stimulation, but absent otherwise. 
It was present in all patients with diaphragmatic palsy after phrenic nerve 
stimulation. Conclusion: The LLR is likely to be produced by both 
intercostal and diaphragm muscles. It is a polysynaptic and multisegmental 
spinal response, probably conveyed by small-diameter nociceptive A-δ and/or 
C fibres and modulated by a supraspinal control. Significance: The LLR 
recorded from the chest wall may constitute, by analogy with the nociceptive 
component of the lower limb flexion reflex in humans, a protective and 
withdrawal spinal reflex response. © 2009 International Federation of 
Clinical Neurophysiology.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm paralysis (rehabilitation, surgery, therapy); nerve stimulation; phrenic nerve pacing; spinal cord injury (rehabilitation, surgery, therapy); thorax wall; 
EMTREE MEDICAL INDEX TERMS
  adult; amplitude modulation; article; artificial ventilation; brain electrophysiology; clinical article; controlled study; electromyogram; experimental study; female; habituation; human; intercostal nerve; latent period; male; median nerve; muscle potential; nerve conduction; neuroanatomy; nociceptive stimulation; phrenic nerve; priority journal; spinal reflex; tracheotomy; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009413071
MEDLINE PMID
  19577512 (http://www.ncbi.nlm.nih.gov/pubmed/19577512)
PUI
  L50568583
DOI
  10.1016/j.clinph.2009.06.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.clinph.2009.06.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13882457&id=doi:10.1016%2Fj.clinph.2009.06.004&atitle=Experimental+study+of+a+late+response+recorded+from+the+thoracic+wall+after+phrenic+nerve+stimulation&stitle=Clin.+Neurophysiol.&title=Clinical+Neurophysiology&volume=120&issue=8&spage=1543&epage=1547&aulast=Rouaud&aufirst=Tiphaine&auinit=T.&aufull=Rouaud+T.&coden=CNEUF&isbn=&pages=1543-1547&date=2009&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 774
TITLE
  Management of cervical spine injuries in young children: Lessons learned: 
Report of 2 cases
AUTHOR NAMES
  Smith J.L.; Ackerman L.L.
AUTHOR ADDRESSES
  (Smith J.L., jodlsmit@iupui.edu) Pediatric Neurosurgery, James Whitcomb 
Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202, 
United States.
(Ackerman L.L.)
CORRESPONDENCE ADDRESS
  J. L. Smith, Pediatric Neurosurgery, James Whitcomb Riley Hospital for 
Children, 702 Barnhill Drive, Indianapolis, IN 46202, United States. Email: 
jodlsmit@iupui.edu
FULL RECORD ENTRY DATE
  2009-08-10
SOURCE
  Journal of Neurosurgery: Pediatrics (2009) 4:1 (64-73). Date of Publication: 
July 2009
VOLUME
  4
ISSUE
  1
FIRST PAGE
  64
LAST PAGE
  73
DATE OF PUBLICATION
  July 2009
ISSN
  1933-0707
  1933-0715 (electronic)
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Previous studies have shown that the correct use of car safety seats can 
protect infants and children from vehicular injury. Although child passenger 
devices are increasingly used in the US, motor vehicle crashes continue to 
be the leading cause of death and acquired disability in infants and 
children younger than 14 years of age. These events are likely related, at 
least in part, to the high percentage of children who are unrestrained or 
improperly restrained. The authors present 2 cases of severe cervical spine 
trauma in young children restrained in car safety seats during a motor 
vehicle crash: 1) a previously healthy 14-month-old girl who was improperly 
restrained in a forward-facing booster seat secured to the vehicle by a lap 
belt, and 2) a previously healthy 30-month-old girl who was a rear seat 
passenger restrained in a car safety seat. This study points out the unique 
challenges encountered in treating cervical spine injuries in infants and 
young children, as well as the lessons learned, and emphasizes the 
significance of continuing efforts to increase family and public awareness 
regarding the importance of appropriate child safety seat selection and use.
EMTREE DRUG INDEX TERMS
  antibiotic agent (intravenous drug administration); infusion fluid; methylprednisolone (drug dose, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; blood analysis; blood culture; case report; cervical spine radiography; child; computer assisted tomography; death; discectomy; drug megadose; female; fluoroscopy; follow up; hospital admission; hospital discharge; human; magnetic resonance angiography; neurologic examination; nuclear magnetic resonance imaging; patient transport; pelvis radiography; preschool child; priority journal; rehabilitation center; respiratory failure (complication); spine fusion; stomach tube; supine position; thorax radiography; tracheostomy; traffic accident; traffic safety; vital sign; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009342624
MEDLINE PMID
  19569913 (http://www.ncbi.nlm.nih.gov/pubmed/19569913)
PUI
  L354881059
DOI
  10.3171/2009.2.PEDS08362
FULL TEXT LINK
  http://dx.doi.org/10.3171/2009.2.PEDS08362
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=19330707&id=doi:10.3171%2F2009.2.PEDS08362&atitle=Management+of+cervical+spine+injuries+in+young+children%3A+Lessons+learned%3A+Report+of+2+cases&stitle=J.+Neursurg.+Pediatr.&title=Journal+of+Neurosurgery%3A+Pediatrics&volume=4&issue=1&spage=64&epage=73&aulast=Smith&aufirst=Jodi+L.&auinit=J.L.&aufull=Smith+J.L.&coden=&isbn=&pages=64-73&date=2009&auinit1=J&auinitm=L
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 775
TITLE
  Tracheostomy in the ICU: An analysis of 443 procedures
AUTHOR NAMES
  Marbán A.; López J.
AUTHOR ADDRESSES
  (Marbán A.; López J.) University Hospital La Paz, Madrid, Spain.
CORRESPONDENCE ADDRESS
  A. Marbán, University Hospital La Paz, Madrid, Spain.
FULL RECORD ENTRY DATE
  2010-07-13
SOURCE
  Critical Care (2009) 13 Suppl. 1 (S8). Date of Publication: 2009
VOLUME
  13
FIRST PAGE
  S8
DATE OF PUBLICATION
  2009
CONFERENCE NAME
  29th International Symposium on Intensive Care and Emergency Medicine
CONFERENCE LOCATION
  Brussels, Belgium
CONFERENCE DATE
  2009-03-24 to 2009-03-27
ISSN
  1364-8535
BOOK PUBLISHER
  BioMed Central Ltd.
ABSTRACT
  Introduction: The aim of this study is to analyse our experience with 
tracheostomies performed in the critical care unit of a tertiary university 
hospital. Methods: A retrospective clinical records review of patients who 
underwent this procedure in a 7-year period. Results: From January 2001 to 
December 2007, 6,333 patients were admiTed to our unit; 1,528 needed 
mechanical ventilation (MV) for more than 48 hours and 443 underwent 
tracheostomy. The median age was 56 years (14 to 88 years); 66% were male. 
The median APACHE II score was 20 (4 to 44). The main diagnoses were 
polytrauma including head injury in 24.2%, other structural neurological 
diseases in 21%, and prolonged weaning of various aetiologies in 35%. The 
percutaneous dilational technique was used in the majority of cases (90%). 
The mean duration of MV prior to tracheostomy was 13.8 days (SD = 6.4). The 
overall complication rate was 6%. Intraprocedural complications were 
atelectasis (0.4%) and bleeding (2%). Two of the patients needed surgical 
control or transfusion (0.4%). Two stoma infections developed in the open 
tracheostomy group. The most frequent complication was tracheal stenosis, 
encountered in 15 patients (3%). The ICU mortality was 20.7%. Of the 351 
patients discharged from the ICU, 45.8% were decannulated prior to discharge 
from the ICU and 31% in the ward; 23% of them could not be decannulated at 
any moment. Ward mortality in the group of patients decannulated in the ICU 
was 5%, 10% in the patients decannulated in the ward and 37% in those who 
failed decannulation, for a total of 50 deaths before hospital discharge 
(11%). The main diagnoses of the patients who died on the ward were: 
residual encephalopathy in 62% (postanoxic, posTraumatic or other causes), 
severe chronic respiratory failure in 10%, spinal cord injury in 6%, and 
neuromuscular disease in 4%. Conclusions: We had a low rate of early 
complications, similar to other series, with no procedure-related deaths 
[1]. Our main complication was airway stenosis. As in other studies, 
patients who needed a tracheostomy belonged to a group of patients with a 
high severity and mortality. Some of them do not recover a satisfactory 
neurological and functional status to be decannulated and present a high 
ward mortality.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency medicine; intensive care; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  airway; APACHE; artificial ventilation; atelectasis; bleeding; brain disease; chronic respiratory failure; death; diagnosis; etiology; functional status; head injury; hospital discharge; infection; male; medical record review; mortality; multiple trauma; neurologic disease; neuromuscular disease; patient; spinal cord injury; stenosis; stoma; Tertiary (period); trachea stenosis; transfusion; university hospital; ward; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70188017
DOI
  10.1186/cc7184
FULL TEXT LINK
  http://dx.doi.org/10.1186/cc7184
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13648535&id=doi:10.1186%2Fcc7184&atitle=Tracheostomy+in+the+ICU%3A+An+analysis+of+443+procedures&stitle=Crit.+Care&title=Critical+Care&volume=13&issue=&spage=S8&epage=&aulast=Marb%C3%A1n&aufirst=A.&auinit=A.&aufull=Marb%C3%A1n+A.&coden=&isbn=&pages=S8-&date=2009&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 776
TITLE
  Combined spinal epidural anaesthesia for ex utero intrapartum treatment 
(EXIT) procedure
AUTHOR NAMES
  Govindarajan A.; Atkinson S.
AUTHOR ADDRESSES
  (Govindarajan A.; Atkinson S.) Department of Anaesthesia, Royal Group of 
Hospitals, Belfast, United Kingdom.
CORRESPONDENCE ADDRESS
  A. Govindarajan, Department of Anaesthesia, Royal Group of Hospitals, 
Belfast, United Kingdom.
FULL RECORD ENTRY DATE
  2009-11-27
SOURCE
  Anaesthesia (2009) 64:7 (800-801). Date of Publication: July 2009
VOLUME
  64
ISSUE
  7
FIRST PAGE
  800
LAST PAGE
  801
DATE OF PUBLICATION
  July 2009
CONFERENCE NAME
  Annual Congress of the Association of Anaesthetists of Great Britain and 
Ireland
CONFERENCE LOCATION
  Torquay, United Kingdom
ISSN
  0003-2409
BOOK PUBLISHER
  Blackwell Publishing Ltd
ABSTRACT
  EXIT (ex utero intrapartum treatment) procedure refers to surgical delivery 
of a fetus while maintaining fetoplacental circulation until the obstructed 
fetal airway has been secured. Neuraxial anaesthesia has been sparingly 
reported to be used as a sole anaesthetic for EXIT procedure [1]. Case 
report A 37-year-old multiparous woman with five previous normal deliveries 
presented at 36 weeks gestation with polyhydramnios. Ultrasound scan 
revealed a 10 x 7 cm sized cystic swelling in the fetus's submandibular 
region. An EXIT was planned to secure the airway either by bronchoscopy, 
direct laryngoscopy or tracheostomy. The mother had a potentially difficult 
airway (Mallampatti grade III, prominent upper incisors and receding 
mandible), so a combined spinal epidural anaesthetic (CSE) was performed 
with intrathecal 0.5% heavy bupivacaine and 300 μg diamorphine. 
Supplementation via epidural catheter was not required. Prior to uterine 
incision an intravenous infusion of nitroglycerine was started to provide 
uterine relaxation and delay placental separation. With the uteroplacental 
circulation intact, the newborn was intubated with difficulty by direct 
laryngoscopy, following which the umbilical cord was cut, the placenta 
delivered and the nitroglycerine infusion discontinued. The EXIT procedure 
lasted for 15 min, during which maternal hemodynamic stability was 
maintained. APGAR scores were 3 and 5 at 1 min and 5 min respectively 
following cessation of feto-placental circulation. Estimated blood loss was 
800 ml and blood transfusion was not needed. Discussion EXIT procedure 
allows for controlled management of potentially life-threatening airway 
obstruction in the newborn. We successfully used neuraxial anaesthesia in 
conjunction with intravenous nitroglycerin to provide controlled uterine 
relaxation without any untoward maternal complications.
EMTREE DRUG INDEX TERMS
  anesthetic agent; bupivacaine; diamorphine; glyceryl trinitrate; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidural anesthesia; Ireland; United Kingdom; 
EMTREE MEDICAL INDEX TERMS
  airway; airway obstruction; anesthesia; Apgar score; bleeding; blood transfusion; bronchoscopy; case report; epidural catheter; epidural drug administration; female; fetus; hydramnios; incision; incisor; infusion; instrumental delivery; intrathecal drug administration; intravenous drug administration; laryngoscopy; mandible; mother; newborn; placenta; placenta circulation; pregnancy; supplementation; swelling; tracheostomy; ultrasound; umbilical cord; uterus; uterus relaxation; vaginal delivery; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70009663
DOI
  10.1111/j.1365-2044.2009.05966.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1365-2044.2009.05966.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032409&id=doi:10.1111%2Fj.1365-2044.2009.05966.x&atitle=Combined+spinal+epidural+anaesthesia+for+ex+utero+intrapartum+treatment+%28EXIT%29+procedure&stitle=Anaesthesia&title=Anaesthesia&volume=64&issue=7&spage=800&epage=801&aulast=Govindarajan&aufirst=A.&auinit=A.&aufull=Govindarajan+A.&coden=&isbn=&pages=800-801&date=2009&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 777
TITLE
  Permanent cardiac pacemaker for cardiac arrest following cervico-dorsal 
spinal injury
AUTHOR NAMES
  Sanghvi A.V.; Chhabra H.S.; Nigam V.; Tandon V.; Mascarenhas A.A.
AUTHOR ADDRESSES
  (Sanghvi A.V., amishsanghvi@rediffmail.com; Chhabra H.S.; Nigam V.; Tandon 
V.; Mascarenhas A.A.) Indian Spinal Injuries Centre, Sector C, Vasant-kunj, 
New Delhi 110070, India.
CORRESPONDENCE ADDRESS
  A. V. Sanghvi, Indian Spinal Injuries Centre, Sector C, Vasant-kunj, New 
Delhi 110070, India. Email: amishsanghvi@rediffmail.com
FULL RECORD ENTRY DATE
  2009-09-25
SOURCE
  European Spine Journal (2009) 18:SUPPL. 2 (S254-S257). Date of Publication: 
July 2009
  Case Reports: Accepted between 9 June 2008 and 16 May 2009 - Electronic 
Only, Book Series Title:
VOLUME
  18
ISSUE
  SUPPL. 2
DATE OF PUBLICATION
  July 2009
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Bradycardia and rarely cardiac arrest as a complication of cervical spine 
injury due to reduced sympathetic activity is well known, which usually 
settles down in 4-6 weeks of injury. There are few case reports in 
literature of high cervical spinal cord injury requiring permanent cardiac 
pacemaker due to this complication, but an injury as low as cervico-dorsal 
junction requiring permanent cardiac pacemaker has never been reported. A 
47-year-old male suffered traumatic C7-D1 dislocation and continued to have 
severe bradycardia with multiple episodes of cardiac arrest till 2 months 
after injury, which finally warranted permanent cardiac pacemaker as a life 
saving measure. Following permanent cardiac pacemaker no cardiac arrest 
occurred and the patient was successfully rehabilitated. The case directs 
our attention to a rare complication of cardiac arrest occurring in an 
injury as low as cervico-dorsal junction when all other causes are ruled out 
and shows importance of using permanent cardiac pacemaker to ensure patient 
safety in community. © 2009 Springer-Verlag.
EMTREE DRUG INDEX TERMS
  antiinfective agent (drug therapy); atropine (drug therapy); ephedrine (drug dose); oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; heart arrest (drug therapy, complication, drug therapy, therapy); sinus node; 
EMTREE MEDICAL INDEX TERMS
  adult; article; attention; blood gas; bone graft; case report; cervical spine; cervical spine dislocation (diagnosis); community; cortical bone; dyspnea; electrocardiogram; heart massage; heart rate; heart rehabilitation; human; hypotension; infection (drug therapy); life; low drug dose; male; nuclear magnetic resonance imaging; oxygen saturation; patient safety; priority journal; sinus bradycardia (complication, diagnosis, drug therapy, therapy); tracheostomy; ventilator; 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  ephedrine (299-42-3, 50-98-6)
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009419313
MEDLINE PMID
  19330363 (http://www.ncbi.nlm.nih.gov/pubmed/19330363)
PUI
  L50478859
DOI
  10.1007/s00586-009-0944-6
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-009-0944-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-009-0944-6&atitle=Permanent+cardiac+pacemaker+for+cardiac+arrest+following+cervico-dorsal+spinal+injury&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=18&issue=SUPPL.+2&spage=&epage=&aulast=Sanghvi&aufirst=Amish+V.&auinit=A.V.&aufull=Sanghvi+A.V.&coden=ESJOE&isbn=&pages=-&date=2009&auinit1=A&auinitm=V
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 778
TITLE
  Juvenile familial ALS: an autopsy case involving multiple systems with 
basophilic inclusions
AUTHOR NAMES
  Mochizuki Y.; Isozaki E.; Hashimoto T.; Shibuya M.; Oyanagi K.; Mizutani T.
AUTHOR ADDRESSES
  (Mochizuki Y.; Mizutani T.) Dept. of Pathol., Tokyo Met. Neurol. Hosp., 
Tokyo Met. Kita Med. and Rehabil. Ctr., .
(Hashimoto T.) Dept. of Pathol., Tokyo Met. Neurol. Hosp., .
(Isozaki E.) Dept. of Neurol., Tokyo Met. Neurol. Hosp., .
(Oyanagi K.) Dept. of Neuropathol., Tokyo Met. Inst. for Neurosci., .
(Shibuya M.) Dept. of Pathol., Tokyo Med. Univ. Hachioji Med. Ctr., .
CORRESPONDENCE ADDRESS
  Y. Mochizuki, Dept. of Pathol., Tokyo Met. Neurol. Hosp., Tokyo Met. Kita 
Med. and Rehabil. Ctr., .
FULL RECORD ENTRY DATE
  2009-12-21
SOURCE
  Neuropathology (2009) 29:3 (365). Date of Publication: June 2009
VOLUME
  29
ISSUE
  3
FIRST PAGE
  365
DATE OF PUBLICATION
  June 2009
CONFERENCE NAME
  Japanese Society of Neuropathology - Abstracts of the 50th Annual Meeting
CONFERENCE LOCATION
  Takamatsu, Japan
CONFERENCE DATE
  2009-06-04 to 2009-06-06
ISSN
  0919-6544
BOOK PUBLISHER
  Blackwell Publishing
ABSTRACT
  A 40-year-old woman had clinical diagnosis of familial ALS with 27 years 
duration of illness. Muscle weakness progressed rapidly resulting into 
tracheostomy positive pressure ventilation started 1.5 years from the onset. 
After 2.5 years, had not been able to move even a bit voluntarily. The brain 
weighed 715 g. The frontal lobe was especially atrophic, and the brainstem 
and the spinal cord were thin. Neuronal loss of the motor nuclei in the 
spinal cord and brainstem, and fiber loss of the corticospinal tract were 
marked. The findings in the involved areas, such as the globus pallidus, 
substantia nigra, and Clarke's column, resembled those of 
respirator-assisted long survival sporadic ALS cases. Basophilic cytoplasmic 
inclusions (BI) were found in the spinal anterior horns, reticular 
formation, striatum, frontal cortex, pontine nuclei and cerebellar dentate 
nucleus. The inclusions were TDP-43-, α-internexin-negative. Although the 
clinical progression of this patient was rapid as the juvenile ALS cases 
with BI, the degeneration was more extensive in this case. The limbic system 
was well preserved, and the finding was different form that in basophilic 
inclusion body disease.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autopsy; Japanese (people); juvenile; neuropathology; society; 
EMTREE MEDICAL INDEX TERMS
  brain; brain stem; cell inclusion; corpus striatum; degeneration; dentate nucleus; diagnosis; female; fiber; frontal cortex; frontal lobe; general aspects of disease; globus pallidus; limbic system; motoneuron nucleus; muscle weakness; patient; positive end expiratory pressure; pyramidal tract; reticular formation; spinal cord; spinal cord ventral horn; substantia nigra; survival; tracheostomy; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70023417
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:&atitle=Juvenile+familial+ALS%3A+an+autopsy+case+involving+multiple+systems+with+basophilic+inclusions&stitle=Neuropathology&title=Neuropathology&volume=29&issue=3&spage=365&epage=&aulast=Mochizuki&aufirst=Y.&auinit=Y.&aufull=Mochizuki+Y.&coden=&isbn=&pages=365-&date=2009&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 779
TITLE
  An autopsy case of motor neuron disease presented with oculomotor palsy
AUTHOR NAMES
  Konno H.; Tanaka Y.; Takahashi T.; Yoshioka M.; Onodera H.
AUTHOR ADDRESSES
  (Konno H.; Tanaka Y.; Takahashi T.; Yoshioka M.; Onodera H.) Dept. of 
Neurology NHO Nishitaga Hosp., .
CORRESPONDENCE ADDRESS
  H. Konno, Dept. of Neurology NHO Nishitaga Hosp., .
FULL RECORD ENTRY DATE
  2009-12-21
SOURCE
  Neuropathology (2009) 29:3 (367). Date of Publication: June 2009
VOLUME
  29
ISSUE
  3
FIRST PAGE
  367
DATE OF PUBLICATION
  June 2009
CONFERENCE NAME
  Japanese Society of Neuropathology - Abstracts of the 50th Annual Meeting
CONFERENCE LOCATION
  Takamatsu, Japan
CONFERENCE DATE
  2009-06-04 to 2009-06-06
ISSN
  0919-6544
BOOK PUBLISHER
  Blackwell Publishing
ABSTRACT
  He felt a difficulty in breathing and uneasy pronunciation at 8 months 
before death, when he was 81 years old. About 3 months later, he had lost 
any abilities of speaking, swallowing and writing because of his generalized 
muscular weakness. He had a tracheotomy, and assist ventilation was started. 
At the 4th month after the disease onset, the oculomotor palsy was appeared 
and increased. The poor response of doll's eye and Bell's phenomenon 
suggested that it was infranuclear paralysis. Histopathology disclosed loss 
of motoneurons and gliosis in the anterior horn of spinal cord, 12th and 7th 
cranial nerve nuclei and ambiguus nucleus. Bunina bodies and round bodies, 
mmunopositive for ubiquitin and TDP-43 antibodies, were also seen in the 
remnant neurons. The 3rd and 6th cranial nerve nuclei, concerning to 
oculomotor function, showed mild neuronal loss and the presence of inclusion 
bodies, same as those seen in the other motor neurons. Betz' giant cells 
were lost from cerebral motor cortex. There was pyramidal tract degeneration 
in the cord and brain stem. The neurogenic muscular atrophy was seen.
EMTREE DRUG INDEX TERMS
  antibody; ubiquitin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autopsy; Japanese (people); motor neuron disease; neuropathology; ophthalmoplegia; society; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; ambiguus nucleus; brain stem; breathing; cell inclusion; cranial nerve; death; degeneration; eye; eye movement control; giant cell; gliosis; hereditary motor sensory neuropathy; histopathology; motoneuron; motor cortex; muscle weakness; nerve cell; paralysis; pyramidal tract; speech; spinal cord; spinal cord ventral horn; swallowing; tracheotomy; writing; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70023425
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09196544&id=doi:&atitle=An+autopsy+case+of+motor+neuron+disease+presented+with+oculomotor+palsy&stitle=Neuropathology&title=Neuropathology&volume=29&issue=3&spage=367&epage=&aulast=Konno&aufirst=H.&auinit=H.&aufull=Konno+H.&coden=&isbn=&pages=367-&date=2009&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 780
TITLE
  Hypoventilation after spinal cord injury
AUTHOR NAMES
  Castriotta R.J.; Murthy J.N.
AUTHOR ADDRESSES
  (Castriotta R.J., Richard.J.Castriotta@uth.tmc.edu; Murthy J.N.) Division of 
Pulmonary, Critical Care, and Sleep Medicine, University of Texas Health 
Science Center at Houston Medical School, MSB 1.274, 6431 Fannin St., 
Houston, TX 72019, United States.
CORRESPONDENCE ADDRESS
  R. J. Castriotta, Division of Pulmonary, Critical Care, and Sleep Medicine, 
University of Texas Health Science Center at Houston Medical School, MSB 
1.274, 6431 Fannin St., Houston, TX 72019, United States. Email: 
Richard.J.Castriotta@uth.tmc.edu
FULL RECORD ENTRY DATE
  2009-08-04
SOURCE
  Seminars in Respiratory and Critical Care Medicine (2009) 30:3 (330-338). 
Date of Publication: June 2009
VOLUME
  30
ISSUE
  3
FIRST PAGE
  330
LAST PAGE
  338
DATE OF PUBLICATION
  June 2009
ISSN
  1069-3424
  1098-9048 (electronic)
BOOK PUBLISHER
  Thieme Medical Publishers, Inc., 333 7th Avenue, New York, United States.
ABSTRACT
  There are ∼12,000 new cases per year in the United States of spinal cord 
injury (SCI) with life expectancies from 11 to 14 years (ventilator 
dependent) to 44 years (non-ventilator dependent). Those with SCI (C2-C8) 
are at great risk for developing hypoventilation, especially during sleep, 
and this risk increases along with the risk of sleep disordered breathing as 
they age. Most will have significantly reduced vital capacity and 
ventilatory reserve because of interruption of neural pathways to the 
diaphragm, chest, and abdomen, resulting in a restrictive ventilatory 
impairment with intact diffusing capacity. Diagnosis entails measurement of 
pCO(2) with capnography both awake and during sleep, optimally along with 
polysomnography to evaluate for all forms of sleep disordered breathing. 
Treatment options include diaphragmatic pacing, full positive pressure 
ventilation through tracheostomy, and noninvasive positive pressure 
ventilation. Some may require mechanical ventilation only during sleep. 
Copyright © 2009 by Thieme Medical Publishers, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypoventilation (complication, diagnosis, etiology, surgery, therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; breathing muscle; capnometry; diaphragm paralysis (therapy); disease association; electromyogram; endotracheal intubation; human; life expectancy; lung function test; muscle training; negative pressure ventilation; nerve stimulation; pathophysiology; polysomnography; positive end expiratory pressure; priority journal; review; sleep disordered breathing; tracheostomy; ventilator; ventral root; vital capacity; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009325648
MEDLINE PMID
  19452393 (http://www.ncbi.nlm.nih.gov/pubmed/19452393)
PUI
  L354832119
DOI
  10.1055/s-0029-1222447
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-0029-1222447
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10693424&id=doi:10.1055%2Fs-0029-1222447&atitle=Hypoventilation+after+spinal+cord+injury&stitle=Semin.+Respir.+Crit.+Care+Med.&title=Seminars+in+Respiratory+and+Critical+Care+Medicine&volume=30&issue=3&spage=330&epage=338&aulast=Castriotta&aufirst=Richard+J.&auinit=R.J.&aufull=Castriotta+R.J.&coden=SRCCE&isbn=&pages=330-338&date=2009&auinit1=R&auinitm=J
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 781
TITLE
  Editorial: Percutaneous tracheostomy coming of age for the neurointensivist?
AUTHOR NAMES
  Hoekema D.
AUTHOR ADDRESSES
  (Hoekema D., dhoekema@neurosurgery.umsmed.edu) Neurocritical Care Unit, 
University of Mississippi Medical Center, Jackson, United States.
CORRESPONDENCE ADDRESS
  D. Hoekema, Neurocritical Care Unit, University of Mississippi Medical 
Center, Jackson, United States. Email: dhoekema@neurosurgery.umsmed.edu
FULL RECORD ENTRY DATE
  2009-12-11
SOURCE
  Neurocritical Care (2009) 10:3 (261-263). Date of Publication: June 2009
VOLUME
  10
ISSUE
  3
FIRST PAGE
  261
LAST PAGE
  263
DATE OF PUBLICATION
  June 2009
ISSN
  1541-6933
BOOK PUBLISHER
  Humana Press, 999 Riverview Drive, Suite 208, Totowa, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  bleeding (complication); editorial; endotracheal tube; health care cost; intensive care; lower respiratory tract infection; neurosurgery; pneumothorax (complication); priority journal; spinal cord injury; surgical infection (complication); trachea injury (complication); trachea stenosis (complication); traumatic brain injury; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2009561936
MEDLINE PMID
  19229665 (http://www.ncbi.nlm.nih.gov/pubmed/19229665)
PUI
  L50434360
DOI
  10.1007/s12028-009-9195-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s12028-009-9195-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15416933&id=doi:10.1007%2Fs12028-009-9195-y&atitle=Editorial%3A+Percutaneous+tracheostomy+coming+of+age+for+the+neurointensivist%3F&stitle=Neurocrit.+Care&title=Neurocritical+Care&volume=10&issue=3&spage=261&epage=263&aulast=Hoekema&aufirst=Dale&auinit=D.&aufull=Hoekema+D.&coden=&isbn=&pages=261-263&date=2009&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 782
TITLE
  Airway management in trauma
AUTHOR NAMES
  Langeron O.; Birenbaum A.; Amour J.
AUTHOR ADDRESSES
  (Langeron O., olivier.langeron@psl.ap-hop-paris.fr; Birenbaum A.; Amour J.) 
Department of Anesthesiology and Resuscitation, Pitié-Salpétrière Hospital, 
47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
CORRESPONDENCE ADDRESS
  O. Langeron, Department of Anesthesiology and Resuscitation, 
Pitié-Salpétrière Hospital, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, 
France. Email: olivier.langeron@psl.ap-hop-paris.fr
FULL RECORD ENTRY DATE
  2009-09-01
SOURCE
  Minerva Anestesiologica (2009) 75:5 (307-311). Date of Publication: May 2009
VOLUME
  75
ISSUE
  5
FIRST PAGE
  307
LAST PAGE
  311
DATE OF PUBLICATION
  May 2009
ISSN
  0375-9393
BOOK PUBLISHER
  Edizioni Minerva Medica S.p.A., Corso Bramante 83-85, Torino, Italy.
ABSTRACT
  Maintenance of a patent and prevention of aspiration are essential for the 
management of the trauma patient, that requires experienced physicians in 
airway control techniques. Difficulties of the airway control in the trauma 
setting are increased by the vital failures, the risk of aspiration, the 
potential cervical spine injury, the combative patient, and the obvious risk 
of difficult tracheal intubation related to specific injury related to the 
trauma. Endotracheal intubation remains the gold standard in trauma patient 
airway management and should be performed via the oral route with a rapid 
sequence induction and a manual in-line stabilization maneuver, to decrease 
the risks previously mentioned. Different techniques to control the airway 
in trauma patients are presented: improvement of the laryngoscopic vision, 
lighted stylet tracheal intubation, retrograde technique for orotracheal 
intubation, the laryngeal mask and the intubating laryngeal mask airways, 
the combitube and cricothyroidotomy. Management of the airway in trauma 
patients requires regular training in these techniques and the knowledge of 
complementary techniques allowing tracheal intubation or oxygenation to 
overcome difficult intubation and to prevent major complications as 
hypoxemia and aspiration.
EMTREE DRUG INDEX TERMS
  etomidate (drug combination, drug therapy); midazolam (drug combination, drug therapy); suxamethonium (drug therapy, pharmacology); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lung injury (drug therapy, drug therapy, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  airway obstruction (therapy); anesthesia; aspiration; cervical spine injury (therapy); conference paper; drug mechanism; endotracheal intubation; epistaxis (complication); extracorporeal oxygenation; human; hypoxemia; laryngeal mask; laryngoscopy; nose injury (complication); spine stabilization; tracheotomy; 
DEVICE TRADE NAMES
  Combitude
CAS REGISTRY NUMBERS
  etomidate (15301-65-2, 33125-97-2, 51919-80-3)
  midazolam (59467-70-8)
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009372174
MEDLINE PMID
  19412149 (http://www.ncbi.nlm.nih.gov/pubmed/19412149)
PUI
  L354967773
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03759393&id=doi:&atitle=Airway+management+in+trauma&stitle=Minerva+Anestesiol.&title=Minerva+Anestesiologica&volume=75&issue=5&spage=307&epage=311&aulast=Langeron&aufirst=O.&auinit=O.&aufull=Langeron+O.&coden=MIANA&isbn=&pages=307-311&date=2009&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 783
TITLE
  Crisis resource management of the airway in a patient with klippel-feil 
syndrome, congenital deafness, and aortic dissection
AUTHOR NAMES
  Khawaja O.M.; Reed J.T.; Shaefi S.; Chitilian H.V.; Sandberg W.S.
AUTHOR ADDRESSES
  (Khawaja O.M.; Reed J.T.; Shaefi S.; Chitilian H.V.; Sandberg W.S., 
wsandberg@partners.org) Department of Anesthesia and Critical Care, Harvard 
Medical School, Massachusetts General Hospital, Boston, MA.
(Sandberg W.S., wsandberg@partners.org) Department of Anesthesia and 
Critical Care, Massachusetts General Hospital, 55 Fruit St., Jackson 4, 
Boston, MA 02114.
CORRESPONDENCE ADDRESS
  W. S. Sandberg, Department of Anesthesia and Critical Care, Massachusetts 
General Hospital, 55 Fruit St., Jackson 4, Boston, MA 02114. Email: 
wsandberg@partners.org
FULL RECORD ENTRY DATE
  2009-07-29
SOURCE
  Anesthesia and Analgesia (2009) 108:4 (1220-1225). Date of Publication: 
April 2009
VOLUME
  108
ISSUE
  4
FIRST PAGE
  1220
LAST PAGE
  1225
DATE OF PUBLICATION
  April 2009
ISSN
  0003-2999
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  Klippel-Feil syndrome is a visually arresting deformity wherein severe 
restriction of cervical motion predicts a difficult airway. Even minor 
distraction of the neck risks cervical spine or neurologic injury, so 
regional techniques, awake fiberoptic intubation, or awake tracheostomy are 
recommended anesthetic approaches. We present a case of aortic dissection in 
a Klippel-Feil syndrome patient for whom congenital bilateral deafness, 
coupled with the urgency of the surgery, mitigated against the recommended 
first-choice techniques. Using anesthesia crisis resource management 
methods, a multi-member team rehearsed predefined roles and then managed the 
airway via inhaled induction of anesthesia, followed by flexible fiberoptic 
intubation. © 2009 International Anesthesia Research Society.
EMTREE DRUG INDEX TERMS
  esmolol; nitroprusside sodium; suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway; aortic dissection (surgery); congenital deafness (congenital disorder); Klippel Feil syndrome; 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesia; anesthesia induction; article; case report; fiber optics; human; intubation; male; priority journal; resource management; surgical technique; 
CAS REGISTRY NUMBERS
  esmolol (81147-92-4, 81161-17-3)
  nitroprusside sodium (14402-89-2, 15078-28-1)
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009307066
MEDLINE PMID
  19299791 (http://www.ncbi.nlm.nih.gov/pubmed/19299791)
PUI
  L354776141
DOI
  10.1213/ane.0b013e3181957d9b
FULL TEXT LINK
  http://dx.doi.org/10.1213/ane.0b013e3181957d9b
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032999&id=doi:10.1213%2Fane.0b013e3181957d9b&atitle=Crisis+resource+management+of+the+airway+in+a+patient+with+klippel-feil+syndrome%2C+congenital+deafness%2C+and+aortic+dissection&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=108&issue=4&spage=1220&epage=1225&aulast=Khawaja&aufirst=Omar+M.&auinit=O.M.&aufull=Khawaja+O.M.&coden=AACRA&isbn=&pages=1220-1225&date=2009&auinit1=O&auinitm=M
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 784
TITLE
  Respiration and amyotrophic lateral sclerosis/motor neuron disease: The role 
of the diaphragm after a decade of experience with diaphragm pacing
AUTHOR NAMES
  Onders R.; Katirji B.; Schilz R.; Elmo M.J.; Kaplan C.; Ignagni A.
AUTHOR ADDRESSES
  (Onders R., raymond.onders@uhhospitals.org; Katirji B.; Schilz R.; Elmo 
M.J.; Kaplan C.; Ignagni A.) University Hospitals Case Medical Center, 
Cleveland, United States.
CORRESPONDENCE ADDRESS
  R. Onders, University Hospitals Case Medical Center, Cleveland, United 
States. Email: raymond.onders@uhhospitals.org
FULL RECORD ENTRY DATE
  2010-03-22
SOURCE
  Amyotrophic Lateral Sclerosis (2009) 10 SUPPL. 1 (189). Date of Publication: 
2009
VOLUME
  10
FIRST PAGE
  189
DATE OF PUBLICATION
  2009
CONFERENCE NAME
  20th International Symposium on ALS/MND
CONFERENCE LOCATION
  Berlin, Germany
CONFERENCE DATE
  2009-12-08 to 2009-12-10
ISSN
  1748-2968
BOOK PUBLISHER
  Informa Healthcare
ABSTRACT
  Background: Diaphragm pacing (DPS) has been used in a series of trials to 
help respiration ranging from spinal cord injured (SCI) patients with pure 
upper motor neuron (UMN) loss of control to patients with pure lower motor 
neuron (LMN) loss from phrenic nerve transection along with direct analysis 
of stimulation of normal subject diaphragms. ALS/MND involves both UMN and 
LMN involvement of the diaphragm. Objectives: To describe how ALS/MND 
diaphragm pathophysiology can affect respiration. Methods: Prospective, 
nonrandomized, controlled, interventional trials under IRB and/or FDA 
approval for use of DPS in human subjects at a single institution. 
Comparisons of diaphragm function from normal to different diseases states 
were compared to ALS/MND. Results: From 1999 to 2009 over 128 human 
diaphragms were surgically evaluated for motor point stimulation for 
ventilation with over 250 patient-years of DPS use. Subjects ranged from 12 
weeks to 77 years old. Diaphragm evaluations included normal subjects 
undergoing elective laparoscopy to SCI patients on ventilators over 25 
years. ALS/MND diaphragms evaluated varied from FVC of 89% predicted to 
continuous mechanical ventilation with tracheostomy for 18 months. 
Pre-operative pulmonary function tests do not predict surgical stimulation 
results. Patients can have high FVC but poor diaphragm function or low FVC 
and excellent stimulatable diaphragms. ALS/MND involvement of the diaphragm 
is heterogeneous. It can be visualized as radial bands or regions of loss of 
motor units and can functionally involve each hemi-diaphragm differently. 
Using frequency stimulation to differentiate muscle fiber type, ALS/MND 
diaphragms that had primarily UMN involvement or suppression of diaphragm 
function with NIV demonstrated conversion to fast twitch (type IIb) muscle 
fibers. DPS can convert ALS/MND diaphragms to more functional type I muscle 
fibers. Used in conjunction with NIV, DPS can prevent atrophy and 
conversion. Implanted DPS electrodes can be used to assess diaphragm burst 
activity which appears to correlate with strength of diaphragm contraction 
and can be serially followed. This has been utilized to identify and treat 
central sleep apnea in ALS/MND. ALS/MND patients with primary LMN 
involvement have diffusely thin non-stimula-table diaphragms. DPS increases 
respiratory compliance by 17% which decreases the work of breathing. ALS/MND 
patients may develop daytime hypoventilation leading to hypercarbia which 
DPS can overcome. During disease course use of DPS can go from several 30 
minutes conditioning sessions a day to 24 hours continuous use to maintain 
ventilation with the need to turn off DPS if death is sought. In 
tracheostomy mechanical ventilated patients, some with intact phrenic motor 
neurons remaining, DPS decreases peak airway pressure and improves posterior 
lobe ventilation leading to less atelectasis and risk for pneumonia. 
Conclusion: ALS/MND patients with respiratory complaints and intact phrenic 
motor neurons that the patient cannot control due to UMN involvement are 
candidates to improve diaphragm movement and ventilation with DPS.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm; nerve cell; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; airway pressure; artificial ventilation; atelectasis; atrophy; central sleep apnea syndrome; conditioning; death; diaphragm movement; disease course; electrode; Food and Drug Administration; human; hypercapnia; hypoventilation; intervention study; laparoscopy; lung function test; motoneuron; motor unit; muscle cell; nerve transection; pathophysiology; patient; phrenic nerve; pneumonia; risk; spinal cord; stimulation; tracheostomy; ventilated patient; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70078650
DOI
  10.3109/17482960903270854
FULL TEXT LINK
  http://dx.doi.org/10.3109/17482960903270854
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17482968&id=doi:10.3109%2F17482960903270854&atitle=Respiration+and+amyotrophic+lateral+sclerosis%2Fmotor+neuron+disease%3A+The+role+of+the+diaphragm+after+a+decade+of+experience+with+diaphragm+pacing&stitle=Amyotrophic+Lateral+Scler.&title=Amyotrophic+Lateral+Sclerosis&volume=10&issue=&spage=189&epage=&aulast=Onders&aufirst=R.&auinit=R.&aufull=Onders+R.&coden=&isbn=&pages=189-&date=2009&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 785
TITLE
  Adolescent paraplegia, morbid obesity, and pickwickian syndrome: outcome of 
gastric bypass surgery
AUTHOR NAMES
  Miyano G.; Kalra M.; Inge T.H.
AUTHOR ADDRESSES
  (Miyano G.; Inge T.H., thomas.inge@cchmc.org) Department of Pediatric 
General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, 
Cincinnati, OH 45229-3039, United States.
(Kalra M.) Division of Pulmonary Medicine, Cincinnati Children's Hospital 
Medical Center, Cincinnati, OH 45229-3039, United States.
CORRESPONDENCE ADDRESS
  T.H. Inge, Department of Pediatric General and Thoracic Surgery, Cincinnati 
Children's Hospital Medical Center, Cincinnati, OH 45229-3039, United 
States. Email: thomas.inge@cchmc.org
FULL RECORD ENTRY DATE
  2009-04-01
SOURCE
  Journal of Pediatric Surgery (2009) 44:3 (e41-e44). Date of Publication: 
March 2009
VOLUME
  44
ISSUE
  3
DATE OF PUBLICATION
  March 2009
ISSN
  0022-3468
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Loss of mobility, such as what occurs as a consequence of spinal cord injury 
or malformation, is a risk factor for excess weight gain and can confound 
weight management efforts. Despite well-documented outcomes of bariatric 
surgery in ambulatory patients, little information is available regarding 
weight loss surgery in adult or adolescent paraplegic patients. A 
15-year-old adolescent boy with a body mass index of 60 kg/m(2) and complete 
paraplegia caused by spina bifida developed metabolic dysfunction, severe 
obstructive sleep apnea, and hypoxemia syndrome. In an effort to avoid a 
tracheostomy for worsening pickwickian syndrome, he was referred for weight 
loss surgery. Laparoscopic Roux-en-Y gastric bypass surgery was safely 
performed and resulted in loss of 55% of body weight (83.8% excess weight 
loss) for 2 years. Risk factors for cardiovascular disease markedly 
improved, and polysomnography demonstrated complete reversal of sleep apnea 
with substantial subjective improvement in daytime breathlessness and 
quality of life. Body composition analysis demonstrated preferential 
reduction in body fat mass compared with lean mass, without detrimental 
effect on bone mineral density. This case illustrates that paraplegia does 
not necessarily impair either weight loss efficacy or comorbidity resolution 
after Roux-en-Y gastric bypass surgery. © 2009 Elsevier Inc. All rights 
reserved.
EMTREE DRUG INDEX TERMS
  calcium (drug combination); cyanocobalamin; glucose (endogenous compound); low density lipoprotein cholesterol (endogenous compound); multivitamin (drug combination); vitamin D (drug combination); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gastric bypass surgery; morbid obesity (surgery); obesity hypoventilation syndrome (complication, disease management); paraplegia (complication, therapy); Roux Y anastomosis; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; bladder catheterization; body composition; body fat; body mass; body weight; body weight loss; bone density; cardiovascular risk; case report; clinical feature; disease course; disease severity; dyspnea; human; hyperglycemia; hyperinsulinemia; hypoxemia; laparoscopic surgery; male; metabolic disorder; neurogenic bladder (therapy); patient safety; physiotherapy; polysomnography; priority journal; quality of life; sleep disordered breathing (diagnosis); spinal dysraphism; tracheostomy; treatment outcome; vitamin supplementation; 
CAS REGISTRY NUMBERS
  calcium (14092-94-5, 7440-70-2)
  cyanocobalamin (53570-76-6, 68-19-9, 8064-09-3)
  glucose (50-99-7, 84778-64-3)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Drug Literature Index (37)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009125061
MEDLINE PMID
  19302844 (http://www.ncbi.nlm.nih.gov/pubmed/19302844)
PUI
  L354299544
DOI
  10.1016/j.jpedsurg.2008.12.014
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jpedsurg.2008.12.014
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223468&id=doi:10.1016%2Fj.jpedsurg.2008.12.014&atitle=Adolescent+paraplegia%2C+morbid+obesity%2C+and+pickwickian+syndrome%3A+outcome+of+gastric+bypass+surgery&stitle=J.+Pediatr.+Surg.&title=Journal+of+Pediatric+Surgery&volume=44&issue=3&spage=&epage=&aulast=Miyano&aufirst=Go&auinit=G.&aufull=Miyano+G.&coden=JPDSA&isbn=&pages=-&date=2009&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 786
TITLE
  Outcomes of patients with spinal cord injury before and after introduction 
of an interdisciplinary tracheostomy team.
AUTHOR NAMES
  Cameron T.S.; McKinstry A.; Burt S.K.; Howard M.E.; Bellomo R.; Brown D.J.; Ross J.M.; Sweeney J.M.; O'Donoghue F.J.
AUTHOR ADDRESSES
  (Cameron T.S.; McKinstry A.; Burt S.K.; Howard M.E.; Bellomo R.; Brown D.J.; 
Ross J.M.; Sweeney J.M.; O'Donoghue F.J.) Austin Hospital, Melbourne, VIC.
CORRESPONDENCE ADDRESS
  T.S. Cameron, Austin Hospital, Melbourne, VIC. Email: 
tanis.cameron@austin.org.au
FULL RECORD ENTRY DATE
  2009-06-04
SOURCE
  Critical care and resuscitation : journal of the Australasian Academy of 
Critical Care Medicine (2009) 11:1 (14-19). Date of Publication: Mar 2009
VOLUME
  11
ISSUE
  1
FIRST PAGE
  14
LAST PAGE
  19
DATE OF PUBLICATION
  Mar 2009
ISSN
  1441-2772
ABSTRACT
  OBJECTIVES: To assess outcomes in patients with spinal cord injury (SCI) and 
a tracheostomy tube (TT), before and after the introduction of a 
tracheostomy review and management service (TRAMS) for ward-based patients. 
DESIGN: Matched-pairs design with two cohorts, before and after the 
intervention. SETTING: 900-bed tertiary hospital in Melbourne, Victoria. 
PARTICIPANTS: SCI patients with a TT that was removed: 34 patients in the 
post-TRAMS period (September 2003 to September 2006) were matched to 34 from 
the pre-TRAMS period (September 1999 to December 2001). INTERVENTION: TRAMS 
was introduced as a consultative team of specialist physicians, clinical 
nurse consultants, physiotherapists and speech pathologists. The team 
coordinated tracheostomy care, conducted twice-weekly rounds, and provided 
policy, education, and support. MAIN OUTCOME MEASURES: Comparison of length 
of stay (LOS), duration of cannulation (DOC), improved communication through 
use of a one-way valve, number of adverse events and related costs. RESULTS: 
Median patient LOS decreased from 60 days (interquartile range [IQR], 
38-106) to 41.5 days (IQR, 29- 62) (P = 0.03). The pre-TRAMS median DOC 
decreased from 22.5 days (IQR, 17-58) to 16.5 days (IQR, 12-25) (P = 0.08). 
Speaking-valve use increased from 35% (12/34) to 82% (28/34) (P < 0.01). 
Median time to a valve trial decreased from 22 days (IQR, 13-44) to 6 days 
(IQR, 4-10) after TT insertion (P < 0.01). There were two 
tracheostomy-related medical emergency calls pre-TRAMS and none post-TRAMS. 
There were no tracheostomy-related deaths in either group. The annual cost 
savings from implementing TRAMS were about eight times greater than the cost 
of service provision. CONCLUSION: Implementing a tracheostomy review and 
management service improved outcomes for SCI patients: they left acute care 
sooner, spoke sooner, and the TT was removed earlier, with associated cost 
savings.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; intensive care; patient care; spinal cord injury (therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cervical spine; cohort analysis; cost control; evaluation study; female; health care quality; human; length of stay; male; middle aged; organization and management; treatment outcome; vertebra; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  19281439 (http://www.ncbi.nlm.nih.gov/pubmed/19281439)
PUI
  L354630866
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14412772&id=doi:&atitle=Outcomes+of+patients+with+spinal+cord+injury+before+and+after+introduction+of+an+interdisciplinary+tracheostomy+team.&stitle=Crit+Care+Resusc&title=Critical+care+and+resuscitation+%3A+journal+of+the+Australasian+Academy+of+Critical+Care+Medicine&volume=11&issue=1&spage=14&epage=19&aulast=Cameron&aufirst=Tanis+S&auinit=T.S.&aufull=Cameron+T.S.&coden=&isbn=&pages=14-19&date=2009&auinit1=T&auinitm=S
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 787
TITLE
  Neurophysiological study in patients with amyotrophic lateral sclerosis in a 
totally locked-in state
AUTHOR NAMES
  Shimizu T.; Kawata A.; Komori T.; Hayashi H.; Oyanagi K.
AUTHOR ADDRESSES
  (Shimizu T., tshimizu@tmnh.fuchu.tokyo.jp; Kawata A.; Hayashi H.) Tokyo 
Metropolitan Neurological Hospital, Tokyo, Japan.
(Komori T.) Saitama Medical University, Saitama, Japan.
(Oyanagi K.) Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan.
CORRESPONDENCE ADDRESS
  T. Shimizu, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. Email: 
tshimizu@tmnh.fuchu.tokyo.jp
FULL RECORD ENTRY DATE
  2010-03-22
SOURCE
  Amyotrophic Lateral Sclerosis (2009) 10 SUPPL. 1 (153). Date of Publication: 
2009
VOLUME
  10
FIRST PAGE
  153
DATE OF PUBLICATION
  2009
CONFERENCE NAME
  20th International Symposium on ALS/MND
CONFERENCE LOCATION
  Berlin, Germany
CONFERENCE DATE
  2009-12-08 to 2009-12-10
ISSN
  1748-2968
BOOK PUBLISHER
  Informa Healthcare
ABSTRACT
  Background: Fifteen to eighteen percent of amyotrophic lateral sclerosis 
(ALS) patients present with ophthalmoplegia and fall into a totally 
locked-in state (TLS) after initiation of tracheostomy positive-pressure 
ventilation (TPPV). Objectives: To assess the neurophysiological function in 
TLS-ALS patients using the techniques of somatosensory evoked potentials 
(SEP) and electroencephalogram (EEG). Methods: SEPs were recorded by 
electrical stimulation of the median nerve at the wrist in seven TLS 
patients (3 men and 4 women, age: 53 to 81 years). All patients showed 
complete ophthalmoplegia and tetraplegia with TPPV all day long. 
Communication with them was entirely impossible. The brain MR images showed 
severe frontotemporal atrophy in all of the patients. The disease duration 
ranged from 5 to 13 years and the duration of ventilator use was 3 to 10 
years. One patient (66 year-old man) had a superoxide dismutase 1 (SOD1) 
gene mutation (Exon 5, Cys146Arg). Erb's potential, cervical/brainstem N13 
potential (C5S-Fz), parietal N20 (CP3/4-Fz) and frontal N30 (F3/4-A), and 
central conduction time (latency differences between N13 peak and N20 peak) 
were analyzed. EEG was recorded from the scalp monopolar electrodes placed 
on Fp1/2, F3/4, C3/4, P3/4, O3/4, F7/8, T3/4 regions, for about 15 to 30 
minutes in the afternoon. The frequency analysis of the EEG was performed 
for a relatively stable 5 seconds of the total recording time using the 
technique of Fast Fourier Transform (FFT). Results: Six out of the seven 
patients showed decreased or abolished parietal N20 and frontal N30. The 
latencies of N13 and central conduction time were also delayed. The patient 
with SOD1 gene mutation showed poor Erb's potentials and no responses of the 
brainstem and cortical components. In EEG analysis, only two patients showed 
occipital alpha waves with slow frequency range (8 to 10 Hz), and the other 
three showed theta to delta waves predominantly on the central-frontal 
regions. In one patient with involuntary jaw movements, the FFT analysis 
could not be examined due to EMG artifact. The patients with occipital slow 
alpha waves showed preserved parietal N20 components, and the patients with 
no N20 components showed theta to delta range EEG without alpha waves. 
Discussion and Conclusions: Along with disease progression of ALS, the 
sensory system could be involved. The lesions might be in the spinal cord, 
brainstem and primary sensory cortex. SOD1-associated ALS might involve the 
peripheral sensory neurons. EEG is desynchronized and slowed in the advanced 
stages, suggesting impaired consciousness of the patients. There might be a 
correlation between the presence of N20 in SEP and the result of EEG-FFT 
analysis. In TLS-ALS patients, communication aids should be applied during 
the stages with preserved SEPs and alpha rhythms of EEG.
EMTREE DRUG INDEX TERMS
  copper zinc superoxide dismutase; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis; electroencephalogram; patient; somatosensory evoked potential; 
EMTREE MEDICAL INDEX TERMS
  alpha rhythm; artifact; atrophy; brain; brain stem; communication aid; consciousness; delta rhythm; disease course; disease duration; electrode; electromyogram; electrostimulation; exon; female; Fourier transformation; frequency analysis; gene mutation; interpersonal communication; jaw movement; latent period; male; median nerve; nuclear magnetic resonance; ophthalmoplegia; positive end expiratory pressure; quadriplegia; recording; scalp; sensory cortex; sensory nerve cell; sensory system; spinal cord; tracheostomy; ventilator; wrist; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70078572
DOI
  10.3109/17482960903270821
FULL TEXT LINK
  http://dx.doi.org/10.3109/17482960903270821
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17482968&id=doi:10.3109%2F17482960903270821&atitle=Neurophysiological+study+in+patients+with+amyotrophic+lateral+sclerosis+in+a+totally+locked-in+state&stitle=Amyotrophic+Lateral+Scler.&title=Amyotrophic+Lateral+Sclerosis&volume=10&issue=&spage=153&epage=&aulast=Shimizu&aufirst=T.&auinit=T.&aufull=Shimizu+T.&coden=&isbn=&pages=153-&date=2009&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 788
TITLE
  A follow-up study for spinal surgery after the onset of symptoms of ALS
AUTHOR NAMES
  Liu X.; Fan D.; Zhang J.; Kang D.
AUTHOR ADDRESSES
  (Liu X.; Fan D., dsfan@yahoo.cn; Zhang J.; Kang D.) Peking University Third 
Hospital, Beijing, China.
CORRESPONDENCE ADDRESS
  D. Fan, Peking University Third Hospital, Beijing, China. Email: 
dsfan@yahoo.cn
FULL RECORD ENTRY DATE
  2010-03-22
SOURCE
  Amyotrophic Lateral Sclerosis (2009) 10 SUPPL. 1 (162). Date of Publication: 
2009
VOLUME
  10
FIRST PAGE
  162
DATE OF PUBLICATION
  2009
CONFERENCE NAME
  20th International Symposium on ALS/MND
CONFERENCE LOCATION
  Berlin, Germany
CONFERENCE DATE
  2009-12-08 to 2009-12-10
ISSN
  1748-2968
BOOK PUBLISHER
  Informa Healthcare
ABSTRACT
  Background and Objectives: Distinguishing between cervical spondylotic 
myelopathy (CSM) and ALS can be difficult, because of their similar clinical 
manifestations. Sometimes, CSM may coexist with ALS since both diseases 
preferentially affect individuals of middle or old age. Attempts to 
differentiate between CSM and ALS must persist until diagnosis of one (or 
both) of the disorders is made, since both the prognosis and treatment of 
the two are different. Choice of surgical treatment remains controversial. 
We investigated 19 patients with ALS to clarify the complications of 
cervical spondylosis and to explore the influence of surgical treatment for 
their prognosis in a retrospective study. Methods: A total of 329 
consecutive patents with definite or probable ALS were enrolled. The 
clinical features, especially the history of spinal surgical treatment, were 
recorded. The patients were followed up every 3 months from visit to death 
or tracheostomy. Results: Of 329 sporadic ALS cases, we found cervical 
spondylosis in 156 patients (47.4%); 19 (5.8%) of them underwent spinal 
surgical treatment in the early stage of the course of their ALS. No 
differences between ALS patients who underwent spinal surgery and other ALS 
patients were noted regarding age at symptom onset, gender and ALSFRSR at 
time of diagnosis (P > 0.05). However, the time from symptom onset to 
diagnosis was significantly longer in patients with spinal surgery (P < 
0.001). In the follow-up study, although these patients consulted our clinic 
because their motor symptoms had progressed after spinal surgery, we found 
that there were no differences in the rate of disease progression and 
survival between two groups (P < 0.05). Conclusions: Our results indicate 
that nearly half of all ALS patients have their disease complicated by 
cervical spondylosis, some of whom even underwent spinal surgery. Although 
the surgery did not obviously hasten the rate of disease progression and 
shorten survival, it lengthens the time from disease onset to diagnosis. A 
careful differential diagnosis for ALS is necessary before making decisions 
about spinal surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  follow up; prognosis; spinal cord disease; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  cervical spondylosis; clinical feature; death; diagnosis; differential diagnosis; disease course; gender; hospital; patent; patient; retrospective study; senescence; surgery; survival; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70078590
DOI
  10.3109/17482960903270839
FULL TEXT LINK
  http://dx.doi.org/10.3109/17482960903270839
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=17482968&id=doi:10.3109%2F17482960903270839&atitle=A+follow-up+study+for+spinal+surgery+after+the+onset+of+symptoms+of+ALS&stitle=Amyotrophic+Lateral+Scler.&title=Amyotrophic+Lateral+Sclerosis&volume=10&issue=&spage=162&epage=&aulast=Liu&aufirst=X.&auinit=X.&aufull=Liu+X.&coden=&isbn=&pages=162-&date=2009&auinit1=X&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 789
TITLE
  Survival probabilities of patients with childhood spinal muscle atrophy
AUTHOR NAMES
  Mannaa M.M.; Kalra M.; Wong B.; Cohen A.P.; Amin R.S.
AUTHOR ADDRESSES
  (Mannaa M.M.; Kalra M., maninderkalra@gmail.com; Amin R.S.) Division of 
Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 
Burnet Avenue, Cincinnati, OH 45229, United States.
(Wong B.) Division of Neurology, Cincinnati Children's Hospital Medical 
Center, Cincinnati, OH, United States.
(Cohen A.P.) Division of Pediatric Surgery, Cincinnati Children's Hospital 
Medical Center, Cincinnati, OH, United States.
CORRESPONDENCE ADDRESS
  M. Kalra, Division of Pulmonary Medicine, Cincinnati Children's Hospital 
Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, United States. 
Email: maninderkalra@gmail.com
FULL RECORD ENTRY DATE
  2009-09-10
SOURCE
  Journal of Clinical Neuromuscular Disease (2009) 10:3 (85-89). Date of 
Publication: March 2009
VOLUME
  10
ISSUE
  3
FIRST PAGE
  85
LAST PAGE
  89
DATE OF PUBLICATION
  March 2009
ISSN
  1522-0443
  1537-1611 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  OBJECTIVE:: Medical and technological advances over the past 2 decades have 
resulted in improved patient care for children with spinal muscular atrophy 
(SMA). The objective of the present study was to describe changes in the 
life expectancy of pediatric patients with SMA over time and to compare 
these findings with previously reported survival patterns. METHODS:: Medical 
records of all patients diagnosed with SMA over a 16-year period (1989-2005) 
at Cincinnati Children's Hospital Medical Center were reviewed. Data 
pertaining to date of birth, type of SMA, medical and surgical 
interventions, pulmonary complications, and date of death were obtained. 
RESULTS:: Kaplan-Meier survival analyses showed a significant improvement in 
survival probabilities in the severest form of SMA. CONCLUSIONS:: We found a 
positive trend in the survival of patients with severe SMA. Although we 
cannot attribute this trend to any single factor, it is likely that advances 
in pulmonary care and aggressive nutritional support have played a 
significant role. Copyright © 2009 by Lippincott Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  life expectancy; spinal muscular atrophy (epidemiology); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; child; clinical article; controlled study; female; human; lung complication; male; medical record; preschool child; priority journal; school child; survival rate; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009424467
MEDLINE PMID
  19258855 (http://www.ncbi.nlm.nih.gov/pubmed/19258855)
PUI
  L355084037
DOI
  10.1097/CND.0b013e318190310f
FULL TEXT LINK
  http://dx.doi.org/10.1097/CND.0b013e318190310f
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15220443&id=doi:10.1097%2FCND.0b013e318190310f&atitle=Survival+probabilities+of+patients+with+childhood+spinal+muscle+atrophy&stitle=J.+Clin.+Neuromuscular+Dis.&title=Journal+of+Clinical+Neuromuscular+Disease&volume=10&issue=3&spage=85&epage=89&aulast=Mannaa&aufirst=Mohannad+M.&auinit=M.M.&aufull=Mannaa+M.M.&coden=JCNDC&isbn=&pages=85-89&date=2009&auinit1=M&auinitm=M
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 790
TITLE
  Tetraplegia and respiratory failure following mild cervical trauma in a 
child with Cornelia de Lange syndrome
AUTHOR NAMES
  Del Gaudio A.; Varano L.; Perrotta F.; Sorrentino E.; Pagano A.
AUTHOR ADDRESSES
  (Del Gaudio A., freddydelgaudio@libero.it; Varano L.; Perrotta F.; 
Sorrentino E.; Pagano A.) Department of Anesthesia and Intensive Care, Casa 
Sollievo Delia Sofferenza Hospital, IRCCS, S. Giovanni Rotondo, Foggia, 
Italy.
(Del Gaudio A., freddydelgaudio@libero.it) 2nd Department of Anesthesia and 
Intensive Care, Casa Sollievo Della Sofferenza Hospital, Viale Cappuccini, 
71013 S. Giovanni Rotondo, Foggia, Italy.
CORRESPONDENCE ADDRESS
  A. Del Gaudio, 2nd Department of Anesthesia and Intensive Care, Casa 
Sollievo Della Sofferenza Hospital, Viale Cappuccini, 71013 S. Giovanni 
Rotondo, Foggia, Italy. Email: freddydelgaudio@libero.it
FULL RECORD ENTRY DATE
  2009-06-26
SOURCE
  Minerva Anestesiologica (2009) 75:3 (169-170). Date of Publication: March 
2009
VOLUME
  75
ISSUE
  3
FIRST PAGE
  169
LAST PAGE
  170
DATE OF PUBLICATION
  March 2009
ISSN
  0375-9393
BOOK PUBLISHER
  Edizioni Minerva Medica S.p.A., Corso Bramante 83-85, Torino, Italy.
ABSTRACT
  Here we report a 6-year-old female patient with Cornelia de Lange syndrome 
who developed tetraplegia and respiratory failure after a seemingly trivial 
spinal trauma due to an spinal malformation that has not yet been described.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (diagnosis); de Lange syndrome; quadriplegia (diagnosis); respiratory failure (therapy); 
EMTREE MEDICAL INDEX TERMS
  article; atelectasis (diagnosis); case report; child; clinical feature; computer assisted tomography; endotracheal intubation; falling; female; gastrostomy; human; intensive care unit; neurologic examination; nuclear magnetic resonance imaging; nutritional support; patient referral; positive end expiratory pressure; preschool child; radiologist; respiration depression (therapy); spine malformation; stomach paresis; thorax radiography; tracheostomy; unconsciousness; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009273734
MEDLINE PMID
  19221546 (http://www.ncbi.nlm.nih.gov/pubmed/19221546)
PUI
  L354689855
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03759393&id=doi:&atitle=Tetraplegia+and+respiratory+failure+following+mild+cervical+trauma+in+a+child+with+Cornelia+de+Lange+syndrome&stitle=Minerva+Anestesiol.&title=Minerva+Anestesiologica&volume=75&issue=3&spage=169&epage=170&aulast=Del+Gaudio&aufirst=A.&auinit=A.&aufull=Del+Gaudio+A.&coden=MIANA&isbn=&pages=169-170&date=2009&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 791
TITLE
  Mortality and morbidity associated with correction of severe cervical 
hyperextension
AUTHOR NAMES
  Poulter G.T.; Garton H.J.L.; Blakemore L.C.; Hensinger R.N.; Graziano G.P.; Farley F.A.
AUTHOR ADDRESSES
  (Poulter G.T.) Department of Orthopedic Surgery, University of California, 
SanFrancisco, CA.
(Garton H.J.L.) Department of Neurosurgery, University of Michigan, Ann 
Arbor, MI.
(Blakemore L.C.) Department of Surgery, Children's National Medical Center, 
Washington, DC.
(Hensinger R.N.; Graziano G.P.; Farley F.A., fafarley@umich.edu) Department 
of Orthopedic Surgery, University of Michigan, Ann Arbor, MI.
(Farley F.A., fafarley@umich.edu) University of Michigan Hospitals, 1500 
East Medical Dr, Ann Arbor, MI 48109.
CORRESPONDENCE ADDRESS
  F. A. Farley, University of Michigan Hospitals, 1500 East Medical Dr, Ann 
Arbor, MI 48109. Email: fafarley@umich.edu
FULL RECORD ENTRY DATE
  2009-08-04
SOURCE
  Spine (2009) 34:4 (378-383). Date of Publication: 15 Feb 2009
VOLUME
  34
ISSUE
  4
FIRST PAGE
  378
LAST PAGE
  383
DATE OF PUBLICATION
  15 Feb 2009
ISSN
  0362-2436
  1528-1159 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
ABSTRACT
  STUDY DESIGN.: Three case reports of patients with treatment of severe 
cervical hyperextension. OBJECTIVE.: Cervical hyperextension is a rare spine 
deformity that is associated with myopathies. Previous reports of surgical 
correction have reported no major operative complications. This report 
outlines our experience with 3 patients who experienced significant 
complications. SUMMARY OF BACKGROUND DATA.: The limited literature on the 
treatment of cervical hyperextension has good to excellent outcomes. 
METHODS.: Three case reports are presented. RESULTS.: Three cases with 
severe cervical hyperextension with intraoperative correction had associated 
morbidity and mortality. One case had a failed intubation requiring 
tracheotomy. This was followed by a successful posterior release with halo 
traction for 2 weeks and then an instrumented posterior cervical fusion. 
This patient died at home 2 weeks after surgery. The second and third cases 
had an intraoperative spinal cord injury during a posterior release for 
cervical hyperextension. CONCLUSION.: Patients with severe cervical 
hyperextension have high neurologic perioperative risk. © 2009, Lippincott 
Williams & Wilkins.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical hyperextension (surgery, therapy); spine malformation (surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; article; case report; cervical spine; clinical feature; compression garment; disease severity; endotracheal intubation; human; kyphoscoliosis; laminectomy; lordosis; male; morbidity; mortality; nuclear magnetic resonance imaging; orthopedic surgery; paresthesia; postoperative complication; priority journal; quadriplegia; radiography; somatosensory evoked potential; spinal cord injury; tracheotomy; traction therapy; weakness; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009347782
MEDLINE PMID
  19214097 (http://www.ncbi.nlm.nih.gov/pubmed/19214097)
PUI
  L354900756
DOI
  10.1097/BRS.0b013e3181947ce4
FULL TEXT LINK
  http://dx.doi.org/10.1097/BRS.0b013e3181947ce4
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2FBRS.0b013e3181947ce4&atitle=Mortality+and+morbidity+associated+with+correction+of+severe+cervical+hyperextension&stitle=Spine&title=Spine&volume=34&issue=4&spage=378&epage=383&aulast=Poulter&aufirst=Gregory+T.&auinit=G.T.&aufull=Poulter+G.T.&coden=SPIND&isbn=&pages=378-383&date=2009&auinit1=G&auinitm=T
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 792
TITLE
  Case series: anesthetic management of patients with spinal and bulbar 
muscular atrophy (Kennedy's disease).
AUTHOR NAMES
  Niesen A.D.; Sprung J.; Prakash Y.S.; Watson J.C.; Weingarten T.N.
AUTHOR ADDRESSES
  (Niesen A.D.; Sprung J.; Prakash Y.S.; Watson J.C.; Weingarten T.N.) 
Department of Anesthesiology, College of Medicine, Mayo Clinic, 200 First 
Street S.W., Rochester, MN, 55905, USA.
CORRESPONDENCE ADDRESS
  A.D. Niesen, Department of Anesthesiology, College of Medicine, Mayo Clinic, 
200 First Street S.W., Rochester, MN, 55905, USA.
FULL RECORD ENTRY DATE
  2009-04-24
SOURCE
  Canadian journal of anaesthesia = Journal canadien d'anesthésie (2009) 56:2 
(136-141). Date of Publication: Feb 2009
VOLUME
  56
ISSUE
  2
FIRST PAGE
  136
LAST PAGE
  141
DATE OF PUBLICATION
  Feb 2009
ISSN
  0832-610X
ABSTRACT
  PURPOSE: Kennedy's disease (KD) is a rare, X-linked recessive, 
neurodegenerative disorder of lower motor neurons characterized by 
progressive proximal limb and bulbar muscular atrophy with spontaneous 
laryngospasm, which may present an anesthetic risk. We undertook a 
computerized search of the Mayo Clinic medical records database between 
January 1996 and May 2008 for patients with KD undergoing general 
anesthesia. Medical records were reviewed for anesthetic techniques and 
perioperative complications. CLINICAL FEATURES: We identified six patients 
with KD, confirmed by DNA testing, who underwent 13 general anesthetics. 
Succinylcholine was used in two patients, and non-depolarizing neuromuscular 
blockers in seven cases, all without adverse effects. Although laryngospasm 
was not identified in any patient, one patient with advanced disease 
experienced postoperative glottic edema, worsening respiratory distress, 
bulbar dysfunction, requiring tracheostomy and prolonged ventilatory 
support. One patient experienced a pneumothorax. CONCLUSION: The potential 
for bulbar dysfunction and muscle weakness in patients with KD places them 
at risk for perioperative complications from anesthesia. Anesthesia 
providers should be cognizant of the different potential anesthetic risk 
factors in these patients.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  neuromuscular blocking agent (adverse drug reaction, drug therapy); neuromuscular depolarizing agent (adverse drug reaction, drug therapy); 
EMTREE DRUG INDEX TERMS
  suxamethonium (adverse drug reaction, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  general anesthesia (adverse drug reaction); spinal muscular atrophy (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; factual database; human; larynx spasm (etiology); male; methodology; middle aged; pathophysiology; postoperative complication (prevention); retrospective study; 
CAS REGISTRY NUMBERS
  suxamethonium (306-40-1, 71-27-2)
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  19247761 (http://www.ncbi.nlm.nih.gov/pubmed/19247761)
PUI
  L354481604
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0832610X&id=doi:&atitle=Case+series%3A+anesthetic+management+of+patients+with+spinal+and+bulbar+muscular+atrophy+%28Kennedy%27s+disease%29.&stitle=Can+J+Anaesth&title=Canadian+journal+of+anaesthesia+%3D+Journal+canadien+d%27anesth%C3%A9sie&volume=56&issue=2&spage=136&epage=141&aulast=Niesen&aufirst=Adam+D&auinit=A.D.&aufull=Niesen+A.D.&coden=&isbn=&pages=136-141&date=2009&auinit1=A&auinitm=D
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 793
TITLE
  Pressure ulcer risk factors in persons with SCI: Part I: Acute and 
rehabilitation stages
AUTHOR NAMES
  Gélis A.; Dupeyron A.; Legros P.; Benaïm C.; Pelissier J.; Fattal C.
AUTHOR ADDRESSES
  (Gélis A., Anthony_gelis@yahoo.fr; Dupeyron A.; Pelissier J.) Département de 
Médecine Physique et de Réadaptation, Centre Hospitalo-Universitaire 
Caremeau, Nîmes, France.
(Gélis A., Anthony_gelis@yahoo.fr; Legros P.; Benaïm C.) EA 3837 
'Physiologie des Adaptations, Performances Motrices et Santé', Université de 
Nice, UFR STAPS, Nice, France.
(Benaïm C.) Service de Médecine Physique et Réadaptation, Centre 
Hospitalo-Universitaire l'Archet, Nice, France.
(Fattal C.) Centre de Rééducation Mutualiste Neurologique PROPARA, Parc 
Euromédecine, Montpellier, France.
(Gélis A., Anthony_gelis@yahoo.fr) Département de Médecine Physique et de 
Réadaptation, Centre Hospitalo-Universitaire Caremeau, Place du Pr Debré, 
30029 Nîmes, France.
CORRESPONDENCE ADDRESS
  A. Gélis, Département de Médecine Physique et de Réadaptation, Centre 
Hospitalo-Universitaire Caremeau, Place du Pr Debré, 30029 Nîmes, France. 
Email: Anthony_gelis@yahoo.fr
FULL RECORD ENTRY DATE
  2009-02-24
SOURCE
  Spinal Cord (2009) 47:2 (99-107). Date of Publication: February 2009
VOLUME
  47
ISSUE
  2
FIRST PAGE
  99
LAST PAGE
  107
DATE OF PUBLICATION
  February 2009
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Background: Pressure ulcers (PUs) are a common complication following a 
spinal-cord injury (SCI). Good prevention requires identifying the 
individuals at risk for developing PUs. Risk assessment scales used nowadays 
were designed on pathophysiological concepts and are not SCI-specific. 
Recently, an epidemiological approach to PU risk factors has been proposed 
to design an SCI-specific assessment tool. The first results seem quite 
disappointing, probably becuase of the level of evidence of the risk factors 
used. Objective: To determine PU risk factors correlated to the patients 
with SCI, medical care management during the acute as well as in the 
rehabilitation and chronic stages. This first part focuses on identifying 
the risk factors during the acute and rehabilitation stages. Materials and 
methods: Systematic review of the literature. Results: Six studies met our 
inclusion criteria. The risk factors during the acute stage of an SCI are 
essentially linked to care management and treatment modalities. There is 
insufficient evidence to make a recommendation on medical risk factors, 
except for low blood pressure on admission to the Emergency Room, with a 
moderate level of evidence. Regarding the rehabilitation stage, no study was 
deemed relevant. Discussion and conclusions: Additional observational 
studies are needed, for both the acute and rehabilitation stages, to improve 
this level of evidence. However, this systematic review unveiled the need 
for a carefully assessed t care management and the related practices, 
especially during the acute stage of an SCI. © 2009 International Spinal 
Cord Society All rights reserved.
EMTREE DRUG INDEX TERMS
  creatinine (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  decubitus; rehabilitation care; risk factor; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  clinical practice; creatinine blood level; demography; emergency care; functional status; hospitalization; human; hypotension; length of stay; lung disease; mental health; osteosynthesis; patient care; patient transport; priority journal; review; risk assessment; systematic review; tracheotomy; urine incontinence; 
CAS REGISTRY NUMBERS
  creatinine (19230-81-0, 60-27-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Dermatology and Venereology (13)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009066291
MEDLINE PMID
  18762807 (http://www.ncbi.nlm.nih.gov/pubmed/18762807)
PUI
  L50258945
DOI
  10.1038/sc.2008.107
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2008.107
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2008.107&atitle=Pressure+ulcer+risk+factors+in+persons+with+SCI%3A+Part+I%3A+Acute+and+rehabilitation+stages&stitle=Spinal+Cord&title=Spinal+Cord&volume=47&issue=2&spage=99&epage=107&aulast=G%C3%A9lis&aufirst=A.&auinit=A.&aufull=G%C3%A9lis+A.&coden=SPCOF&isbn=&pages=99-107&date=2009&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 794
TITLE
  A comparative analysis of open and endovascular repair for the ruptured 
descending thoracic aorta
AUTHOR NAMES
  Patel H.J.; Williams D.M.; Upchurch Jr. G.R.; Dasika N.L.; Deeb G.M.
AUTHOR ADDRESSES
  (Patel H.J., hjpatel@med.umich.edu; Upchurch Jr. G.R.; Deeb G.M.) Department 
of Surgery, University of Michigan Cardiovascular Center, Ann Arbor, Mich, 
United States.
(Williams D.M.; Dasika N.L.) Department of Radiology, University of Michigan 
Cardiovascular Center, Ann Arbor, Mich, United States.
CORRESPONDENCE ADDRESS
  H.J. Patel, Department of Surgery, University of Michigan Cardiovascular 
Center, Ann Arbor, Mich, United States. Email: hjpatel@med.umich.edu
FULL RECORD ENTRY DATE
  2009-12-22
SOURCE
  Journal of Vascular Surgery (2009) 50:6 (1265-1270). Date of Publication: 
December 2009
VOLUME
  50
ISSUE
  6
FIRST PAGE
  1265
LAST PAGE
  1270
DATE OF PUBLICATION
  December 2009
ISSN
  0741-5214
BOOK PUBLISHER
  Mosby Inc.
ABSTRACT
  Background: Successful repair of the ruptured (non-traumatic) descending 
thoracic aorta (rTA) remains a formidable clinical challenge. Although 
effective for rTA, traditional open repair (DTAR) has significant associated 
morbidity. With expanding indications for thoracic endovascular aortic 
repair (TEVAR), we describe our experience with TEVAR and DTAR in this 
high-risk setting to elucidate their evolving roles. Methods: Since the 
inception of our thoracic aortic endovascular program in 1993, 69 patients 
underwent DTAR (34) or TEVAR (35) for rTA. Patients underwent TEVAR if they 
were considered nonoperative candidates because of extensive comorbidities 
(n = 31; 88.6%) or had extremely favorable anatomy for endovascular repair 
(eg, mid-descending saccular aneurysm, n = 4). Aortic pathology causing 
rupture was fusiform aneurysm (18), saccular aneurysm/ulcer (22), and 
dissection (29). Associated aortobronchial fistulae (12) and aortoesophageal 
(1) fistulae were also present in 18.8%. Arch repair was needed in 46; total 
descending repair was needed in 33. Follow-up was 100% complete (mean 37.4 
months). Results: Mean age was 65.9 years (DTAR 60.3 year vs TEVAR 71.3 
years, P = .005). In-hospital or 30-day mortality was seen in 13 patients 
(TEVAR n = 4; 11.4% vs DTAR n = 9; 26.5%, P = .13). Median length of stay 
was shorter after TEVAR (8 days vs DTAR 15 days, P = .02). Mean Kaplan-Meier 
survival was similar between groups (TEVAR 67.4 months vs DTAR 65.0 months, 
P = .7). By multivariate analysis, independent predictors of a composite 
outcome of early mortality, stroke, permanent spinal cord ischemia, or need 
for dialysis or tracheostomy included the presentation with hemodynamic 
instability (P < .001) and treatment with conventional open repair (P = 
.02). Conclusion: An endovascular approach for the ruptured (non-traumatic) 
descending thoracic aorta reduces early morbidity, mortality, and duration 
of hospitalization, while providing equivalent late outcomes even in an 
older group largely considered high risk for open repair. These data support 
a paradigm shift, with TEVAR emerging as the preferred therapy for all 
patients presenting with descending aortic rupture. © 2009 Society for 
Vascular Surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aneurysm rupture (surgery); aortic reconstruction; descending aorta; endovascular aneurysm repair; 
EMTREE MEDICAL INDEX TERMS
  abdominal aortic aneurysm; adult; aged; aortic arch; aortic disease; aortobronchial fistula; aortoesophageal fistula; article; cerebrovascular accident; chronic obstructive lung disease; comorbidity; comparative study; congestive heart failure; coronary artery disease; dialysis; dissecting aneurysm; endovascular surgery; female; hemodynamics; hospitalization; human; major clinical study; male; morbidity; mortality; outcome assessment; peripheral occlusive artery disease; priority journal; saccular aneurysm; spinal cord ischemia; tracheostomy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009612569
MEDLINE PMID
  19782517 (http://www.ncbi.nlm.nih.gov/pubmed/19782517)
PUI
  L50654881
DOI
  10.1016/j.jvs.2009.07.091
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jvs.2009.07.091
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07415214&id=doi:10.1016%2Fj.jvs.2009.07.091&atitle=A+comparative+analysis+of+open+and+endovascular+repair+for+the+ruptured+descending+thoracic+aorta&stitle=J.+Vasc.+Surg.&title=Journal+of+Vascular+Surgery&volume=50&issue=6&spage=1265&epage=1270&aulast=Patel&aufirst=Himanshu+J.&auinit=H.J.&aufull=Patel+H.J.&coden=JVSUE&isbn=&pages=1265-1270&date=2009&auinit1=H&auinitm=J
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 795
TITLE
  Adrenal gland injury secondary to blunt traumatic mechanisms: A marker of 
overall injury severity
AUTHOR NAMES
  Stawicki S.P.; Seamon M.J.; Carvalho C.M.; Bhoot N.; Sharma R.; Schrag S.P.; Steinberg S.M.
AUTHOR ADDRESSES
  (Stawicki S.P., stawicki.ace@gmail.com) Department of Surgery, St Luke's 
Hospital and Health Network, Bethlehem, PA, United States.
(Stawicki S.P., stawicki.ace@gmail.com; Steinberg S.M.) Department of 
Surgery, Division of Critical Care, Trauma, and Burn, The Ohio State 
University Medical Center, 395 West 10th Avenue, Columbus, OH 43210, United 
States.
(Stawicki S.P., stawicki.ace@gmail.com; Seamon M.J.; Bhoot N.; Sharma R.; 
Schrag S.P.; Steinberg S.M.) OPUS 12 Foundation, Columbus, OH, United 
States.
(Seamon M.J.; Carvalho C.M.) Department of Surgery, Section of 
Trauma/Critical Care, Temple University School of Medicine, Philadelphia, 
PA, United States.
(Bhoot N.) Department of Surgery, Bronx-Lebanon Hospital Center, Bronx, NY, 
United States.
(Sharma R.) Roswell Park Cancer Institute, University of Buffalo (SUNY), 
Buffalo, NY, United States.
(Schrag S.P.) Department of Surgery, Jersey City Medical Center, Jersey 
City, NJ, United States.
CORRESPONDENCE ADDRESS
  S.P. Stawicki, Department of Surgery, Division of Critical Care, Trauma, and 
Burn, The Ohio State University Medical Center, 395 West 10th Avenue, 
Columbus, OH 43210, United States. Email: stawicki.ace@gmail.com
FULL RECORD ENTRY DATE
  2009-04-21
SOURCE
  Endokrynologia Polska (2009) 60:1 (2-8). Date of Publication: 
January/February 2009
VOLUME
  60
ISSUE
  1
FIRST PAGE
  2
LAST PAGE
  8
DATE OF PUBLICATION
  January/February 2009
ISSN
  0423-104X
BOOK PUBLISHER
  Via Medica, Ul. Swietokrzyska 73, Gdansk, Poland.
ABSTRACT
  Introduction: Adrenal gland injuries (AGI) are seen increasingly frequently 
owing to advances in modern imaging techniques. This study describes a 
series of patients with blunt AGI, with the emphasis on AGI as a marker of 
injury severity, CT-radiographic classification of AGI and associated injury 
patterns. Material and methods: A retrospective review of blunt trauma 
patients with AGI was performed. Variables examined included demographics, 
mechanism of injury, length of hospital and ICU stay, clinical status on 
admission, AGI characteristics, associated injuries, complications, 
procedures, mortality and discharge disposition. Results: There were 29 AGI 
patients with a mean injury severity score of 25. The most common injury 
mechanisms were motor-vehicular collisions (15/29) and falls (5/29). 
Right-sided AGI (16/29) outnumbered left-sided (12/29) injuries. The most 
common CT-radiographic types of AGI were adrenal gland contusions and 
lacerations with limited "blush". While patterns of injuries differed 
between right and left-sided AGI, the mean number of injuries did not. The 
most common associated injuries included extremity (21/29), rib (20/29) and 
spinal fractures (18/29). Common procedures included orthopaedic fixation 
(10/29), vena cava filter (8/29) and tracheostomy (5/29). A median of two 
complications per patient was reported, including adrenal insufficiency in 
two patients. Mortality was 17%. The median hospital and ICU length of stay 
were 15 and 12 days, respectively. Conclusions: Adrenal gland injury is 
associated with significant morbidity and mortality. With modern imaging 
modalities capable of reliably detecting adrenal injury, the presence of AGI 
should be considered a marker of overall injury severity. The authors 
provide a CT - radiographic classification of adrenal injuries.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adrenal disease (diagnosis); adrenal gland injury (diagnosis); blunt trauma; injury severity; 
EMTREE MEDICAL INDEX TERMS
  adrenal insufficiency; adult; article; clinical article; computer assisted tomography; disease classification; falling; female; fracture fixation; human; length of stay; limb fracture; male; mortality; rib fracture; spine fracture; tracheostomy; traffic accident; vena cava filter; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Urology and Nephrology (28)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, Polish
EMBASE ACCESSION NUMBER
  2009170542
MEDLINE PMID
  19224498 (http://www.ncbi.nlm.nih.gov/pubmed/19224498)
PUI
  L354443685
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0423104X&id=doi:&atitle=Adrenal+gland+injury+secondary+to+blunt+traumatic+mechanisms%3A+A+marker+of+overall+injury+severity&stitle=Endokrynol.+Pol.&title=Endokrynologia+Polska&volume=60&issue=1&spage=2&epage=8&aulast=Stawicki&aufirst=S.+Peter&auinit=S.P.&aufull=Stawicki+S.P.&coden=EDPKA&isbn=&pages=2-8&date=2009&auinit1=S&auinitm=P
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 796
TITLE
  Pyogenic spinal infection in intravenous drug users
AUTHOR NAMES
  Street J.; Lenehan B.; Fisher C.
AUTHOR ADDRESSES
  (Street J.; Lenehan B.; Fisher C.) Combined Neurosurgical and Orthopaedic 
Spine Programme, University of British Columbia, Vancouver General Hospital, 
Vancouver, Canada.
CORRESPONDENCE ADDRESS
  J. Street, Combined Neurosurgical and Orthopaedic Spine Programme, 
University of British Columbia, Vancouver General Hospital, Vancouver, 
Canada.
FULL RECORD ENTRY DATE
  2010-01-18
SOURCE
  Journal of Spinal Cord Medicine (2009) 32:4 (494-495). Date of Publication: 
2009
VOLUME
  32
ISSUE
  4
FIRST PAGE
  494
LAST PAGE
  495
DATE OF PUBLICATION
  2009
CONFERENCE NAME
  Congress on Spinal Cord Medicine and Rehabilitation
CONFERENCE LOCATION
  Dallas, TX, United States
CONFERENCE DATE
  2009-09-23 to 2009-09-26
ISSN
  1079-0268
BOOK PUBLISHER
  American Paraplegia Society
ABSTRACT
  Objectives: To evaluate the demographics, presentation, treatment and 
outcomes of spinal infection in a population of intravenous drug users. 
Design: Prospective cohort study. Methods: Data on all patients with 
pyogenic spinal infection presenting to a quaternary referral center was 
obtained from a prospectively maintained database. Results: Over the 5-year 
study period, 102 patients were treated for primary pyogenic infection of 
the spine of whom 51 were intravenous drug users (IVDU). Of this IVDU group 
there were 34 males. Mean age was 43 years (range 25-57 y). 23 had HIV, 43, 
hepatitis C and 13, hepatitis B. All were using cocaine, 26 were also using 
heroin and 44 more than 3 recreational drugs. 30 patients presented with 
axial pain with a mean duration of 51 days (range 3-120 d). 31 were ASIA D 
or worse with 8 ASIA A. Mean Motor Score of patients with deficit was 58.6. 
Most common ASIA Motor Levels were C4 and C5. Mean duration of neurological 
symptoms was 7 days (range 1-60 d). None had previous surgery for spinal 
infection. 26 were receiving IV antibiotics for known spinal infection. Mean 
presenting temperature was 37.4°C (range 35.9-39.9,19 > 37.5°C), mean ESR 
60.8 (range 6-140, 43 > 20), mean CRP 87.75 (1.5-253, 46 > 20), mean WCC 
10.2 (range 3.7-30.4, 14 > 11) and 33 patients had positive blood cultures 
(19 MSSA, 9 MRSA). 44 patients were treated surgically. 32 had infection of 
the cervical spine, 9 thoracic and 3 lumbar. 22 had a posterior approach 
alone, 13 had anterior only while 9 required combined. Mean operative time 
was 263 min (range 62-742 min). 13 required tracheostomy. 7 required early 
revision for hardware failure and 2 for surgical wound infection. Mean 
duration of antibiotic treatment was 49 days (range 28-116 d). 26 patients 
had single-agent therapy. 17 had MSSA and 17 MRSA. At discharge 28 patients 
had neurological improvement (mean 20 ASIA points, range 1-55), 11 had 
deterioration (mean 13, range 1-50) and 5 were unchanged. There were no 
in-hospital deaths. At 2 years after index admission, 13 patients were dead 
and none were attending the unit for follow-up. Conclusions: Primary 
pyogenic spinal infection in IV drug users typically presents with sepsis 
and acute cervical tetraplegia. Surgical management must be prompt and 
aggressive with significant neurological improvement expected in the 
majority of patients.
EMTREE DRUG INDEX TERMS
  antibiotic agent; cocaine; diamorphine; recreational drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  infection; intravenous drug abuse; rehabilitation; spinal cord; 
EMTREE MEDICAL INDEX TERMS
  antibiotic therapy; blood culture; cervical spine; cohort analysis; computer; data base; death; deterioration; drug use; follow up; hepatitis; hepatitis C; hospital; Human immunodeficiency virus; male; neurologic disease; pain; patient; population; quadriplegia; Quaternary (period); sepsis; spine; surgery; surgical infection; temperature; therapy; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
PUI
  L70036537
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:&atitle=Pyogenic+spinal+infection+in+intravenous+drug+users&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=32&issue=4&spage=494&epage=495&aulast=Street&aufirst=J.&auinit=J.&aufull=Street+J.&coden=&isbn=&pages=494-495&date=2009&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 797
TITLE
  Persistent dysphagia and mechanical glottic paralysis : CCCCCComplications 
of a ventral fracture spondylodesis with Forestier's disease
ORIGINAL (NON-ENGLISH) TITLE
  Persistierende dysphagie und mechanische glottisparese : Komplikation einer 
ventralen frakturspondylodese bei morbus forestier
AUTHOR NAMES
  Löhrer L.; Schmid S.; Hofbauer V.R.; Hartensuer R.; Raschke M.J.; Vordemvenne T.
AUTHOR ADDRESSES
  (Löhrer L., Lars.Loehrer@ukmuenster.de; Hofbauer V.R.; Hartensuer R.; 
Raschke M.J.; Vordemvenne T.) Klinik und Poliklinik für Unfall-, Hand- und 
Wiederherstellungschirurgie, Universitätsklinikum Münster, Waldeyerstr. 1, 
48149 Münster, Germany.
(Schmid S.) Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, 
Universitätsklinikum Münster, Münster, Germany.
CORRESPONDENCE ADDRESS
  L. Löhrer, Klinik und Poliklinik für Unfall-, Hand- und 
Wiederherstellungschirurgie, Universitätsklinikum Münster, Waldeyerstr. 1, 
48149 Münster, Germany. Email: Lars.Loehrer@ukmuenster.de
FULL RECORD ENTRY DATE
  2009-09-22
SOURCE
  Unfallchirurg (2009) 112:1 (76-80). Date of Publication: January 2009
VOLUME
  112
ISSUE
  1
FIRST PAGE
  76
LAST PAGE
  80
DATE OF PUBLICATION
  January 2009
ISSN
  0177-5537
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Persistent dysphagia after ventral instrumentation of a patient with a 
cervical spine fracture and diffuse idiopathic skeletal hyperostosis (DISH, 
or Forestier's disease) is a rare but dramatic complication. In this case 
report some pathogenetic factors are discussed. Accurate resection of the 
spondylophytes should be considered to avoid a ventral protrusion of the 
plate. © 2008 Springer Medizin Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing hyperostosis (diagnosis, surgery); cervical spine fracture (diagnosis, surgery); dysphagia (complication); spondylodesis; vocal cord paralysis (complication); 
EMTREE MEDICAL INDEX TERMS
  adult respiratory distress syndrome (therapy); aged; article; artificial ventilation; bone plate; case report; computed tomographic angiography; decompression; devices; human; laryngoscopy; male; pathogenesis; postoperative complication (complication); prosthesis infection (complication); spine radiography; spine surgery; tracheotomy; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Otorhinolaryngology (11)
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  2009413965
MEDLINE PMID
  19096821 (http://www.ncbi.nlm.nih.gov/pubmed/19096821)
PUI
  L50368457
DOI
  10.1007/s00113-008-1518-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00113-008-1518-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01775537&id=doi:10.1007%2Fs00113-008-1518-5&atitle=Persistent+dysphagia+and+mechanical+glottic+paralysis+%3A+CCCCCComplications+of+a+ventral+fracture+spondylodesis+with+Forestier%27s+disease&stitle=Unfallchirurg&title=Unfallchirurg&volume=112&issue=1&spage=76&epage=80&aulast=L%C3%B6hrer&aufirst=L.&auinit=L.&aufull=L%C3%B6hrer+L.&coden=UNFAE&isbn=&pages=76-80&date=2009&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 798
TITLE
  Advance care directives for people with spinal cord injury: A neglected need
AUTHOR NAMES
  Marshall R.
AUTHOR ADDRESSES
  (Marshall R.) South Australian Spinal Cord Injury Service, .
(Marshall R.) School of Medicine, Faculty of Health Sciences, University of 
Adelaide, .
(Marshall R.) Treatment Ethics Committee, Royal Adelaide Hospital, Adelaide, 
SA, Australia.
(Marshall R.) Continuing Professional Development Committee, .
(Marshall R.) Education Committee, Australasian Faculty of Rehabilitation 
Medicine, Royal Australasian College of Physicians, Sydney, NSW, Australia.
CORRESPONDENCE ADDRESS
  R. Marshall, Treatment Ethics Committee, Royal Adelaide Hospital, Adelaide, 
SA, Australia.
FULL RECORD ENTRY DATE
  2008-01-09
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2008) 13:3 (45-52). Date of 
Publication: Winter 2008
VOLUME
  13
ISSUE
  3
FIRST PAGE
  45
LAST PAGE
  52
DATE OF PUBLICATION
  Winter 2008
ISSN
  1082-0744
BOOK PUBLISHER
  Thomas Land Publishers Inc., 255 Jefferson Road, St. Louis, United States.
ABSTRACT
  Advance care directives are rarely used by people with chronic spinal cord 
injury, but they could be used more often to protect not only against 
unwanted treatments but to ensure that desired treatment occurs, 
particularly as there may be differing perceptions regarding quality of life 
between the patient and those providing acute care. © 2008 Thomas Land 
Publishers, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  health care need; spinal cord injury (disease management, rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; human; intensive care unit; medical decision making; patient care; quality of life; resuscitation; review; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007617778
PUI
  L350293481
DOI
  10.1310/sci1303-45
FULL TEXT LINK
  http://dx.doi.org/10.1310/sci1303-45
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2Fsci1303-45&atitle=Advance+care+directives+for+people+with+spinal+cord+injury%3A+A+neglected+need&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=13&issue=3&spage=45&epage=52&aulast=Marshall&aufirst=Ruth&auinit=R.&aufull=Marshall+R.&coden=TSIRF&isbn=&pages=45-52&date=2008&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 799
TITLE
  Definitive establishment of airway control is critical for optimal outcome 
in lower cervical spinal cord injury.
AUTHOR NAMES
  Hassid V.J.; Schinco M.A.; Tepas J.J.; Griffen M.M.; Murphy T.L.; Frykberg E.R.; Kerwin A.J.
AUTHOR ADDRESSES
  (Hassid V.J.; Schinco M.A.; Tepas J.J.; Griffen M.M.; Murphy T.L.; Frykberg 
E.R.; Kerwin A.J.) Department of Surgery, University of Florida Health 
Science Center, Jacksonville, Florida 32209, USA.
CORRESPONDENCE ADDRESS
  V.J. Hassid, Department of Surgery, University of Florida Health Science 
Center, Jacksonville, Florida 32209, USA.
FULL RECORD ENTRY DATE
  2009-01-21
SOURCE
  The Journal of trauma (2008) 65:6 (1328-1332). Date of Publication: Dec 2008
VOLUME
  65
ISSUE
  6
FIRST PAGE
  1328
LAST PAGE
  1332
DATE OF PUBLICATION
  Dec 2008
ISSN
  1529-8809 (electronic)
ABSTRACT
  BACKGROUND: Respiratory complications can undermine outcome from low 
cervical spinal cord injury (SCI) (C5-T1). Most devastating of these is 
catastrophic loss of airway control. This study sought to determine the 
incidence and effect of catastrophic airway loss (CLA) and to define the 
need for elective intubation with subsequent tracheostomy to prevent 
potentially fatal outcomes. METHODS: A database of 54,838 consecutive 
patients treated in a level I trauma center between January 1988 and 
December 2004 was queried to identify patients with low cervical SCI, 
without traumatic brain injury. Patients were then stratified into complete 
or incomplete SCI groups, based on clinical assessment of their SCI. 
Mortality, age, injury severity, need for intubation, and tracheostomy were 
analyzed for each group using Fisher's exact test or Student's t test, as 
appropriate, accepting p < 0.05 as significant. RESULTS: One hundred 
eighty-six patients met inclusion criteria. The majority of low cervical 
spinal cord injuries were complete (58%). Overall, 127 (68%) patients 
required intubation, 88 (69%) required tracheostomy, and 27 died (15% of 
study population). Between each group there were significant differences in 
age and Injury Severity Score, however, within each group there were no 
significant differences in either. Eleven CSCI patients were not intubated; 
four of whom were at family request. Six of the remaining seven patients 
encountered fatal catastrophic airway loss. One patient was discharged to 
rehabilitation. Patients with incomplete SCI required intubation less 
frequently (38%); however, 50% of those required tracheostomy for 
intractable pulmonary failure. CONCLUSIONS: These data indicate that 
regardless of severity of low cervical SCI, immediate, thorough evaluation 
for respiratory failure is necessary. Early intubation is mandatory for CSCI 
patients. For incomplete patients evidence of respiratory failure should 
prompt immediate airway intervention, half of whom will require 
tracheostomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  apnea (etiology, therapy); cervical spine; endotracheal intubation; respiratory failure (etiology, therapy); resuscitation; spinal cord injury (complication, therapy); spine fracture (complication, therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; child; cross-sectional study; female; human; incidence; injury; injury scale; intensive care unit; male; middle aged; mortality; retrospective study; survival rate; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  19077622 (http://www.ncbi.nlm.nih.gov/pubmed/19077622)
PUI
  L550085831
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15298809&id=doi:&atitle=Definitive+establishment+of+airway+control+is+critical+for+optimal+outcome+in+lower+cervical+spinal+cord+injury.&stitle=J+Trauma&title=The+Journal+of+trauma&volume=65&issue=6&spage=1328&epage=1332&aulast=Hassid&aufirst=Victor+J&auinit=V.J.&aufull=Hassid+V.J.&coden=&isbn=&pages=1328-1332&date=2008&auinit1=V&auinitm=J
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 800
TITLE
  OUTCOME after spinal-cord injury: Influence of specific treatment and 
prevention modalities
AUTHOR NAMES
  Wyndaele J.J.
AUTHOR ADDRESSES
  (Wyndaele J.J., spinalcord@uza.be) Antwerp University Hospital, Antwerp, 
Belgium.
CORRESPONDENCE ADDRESS
  J. J. Wyndaele, Antwerp University Hospital, Antwerp, Belgium. Email: 
spinalcord@uza.be
FULL RECORD ENTRY DATE
  2009-02-03
SOURCE
  Spinal Cord (2008) 46:11 (709). Date of Publication: November 2008
VOLUME
  46
ISSUE
  11
FIRST PAGE
  709
DATE OF PUBLICATION
  November 2008
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
EMTREE DRUG INDEX TERMS
  papaverine (pharmacology); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (disease management, prevention); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; editorial; electrostimulation; ergometry; exercise; health hazard; health services research; human; information processing; nerve stimulation; nonhuman; obesity; phrenic nerve; priority journal; quality of life; respiratory failure; smoking; spinal cord blood flow; tracheostomy; treatment outcome; validation process; vestibular stimulation; 
CAS REGISTRY NUMBERS
  papaverine (58-74-2, 61-25-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Clinical and Experimental Pharmacology (30)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2009011485
MEDLINE PMID
  18987638 (http://www.ncbi.nlm.nih.gov/pubmed/18987638)
PUI
  L354034963
DOI
  10.1038/sc.2008.130
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2008.130
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2008.130&atitle=OUTCOME+after+spinal-cord+injury%3A+Influence+of+specific+treatment+and+prevention+modalities&stitle=Spinal+Cord&title=Spinal+Cord&volume=46&issue=11&spage=709&epage=&aulast=Wyndaele&aufirst=J.J.&auinit=J.J.&aufull=Wyndaele+J.J.&coden=SPCOF&isbn=&pages=709-&date=2008&auinit1=J&auinitm=J
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 801
TITLE
  The use of tracheal stoma stents in high spinal cord injury: A 
patient-friendly alternative to long-term tracheostomy tubes
AUTHOR NAMES
  Hall A.M.; Watt J.W.H.
AUTHOR ADDRESSES
  (Hall A.M., alih101@yahoo.com; Watt J.W.H.) North West Regional Spinal 
Injuries Centre, Southport and Formby District General Hospital, Southport, 
United Kingdom.
(Hall A.M., alih101@yahoo.com) Department of Anaesthesia, Southport and 
Formby District General Hospital, Town Lane Kew, Southport, Merseyside PR8 
6PN, United Kingdom.
CORRESPONDENCE ADDRESS
  A. M. Hall, Department of Anaesthesia, Southport and Formby District General 
Hospital, Town Lane Kew, Southport, Merseyside PR8 6PN, United Kingdom. 
Email: alih101@yahoo.com
FULL RECORD ENTRY DATE
  2009-02-03
SOURCE
  Spinal Cord (2008) 46:11 (753-755). Date of Publication: November 2008
VOLUME
  46
ISSUE
  11
FIRST PAGE
  753
LAST PAGE
  755
DATE OF PUBLICATION
  November 2008
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Case series. Setting: North West Regional Spinal Injuries 
Unit, Southport and Formby District General Hospital, UK. Objectives: To 
identify a novel type of tracheal stents for use in patients with high 
spinal cord injury. Patients with high spinal cord injury (above C4) 
frequently have significant respiratory impairment and may require long-term 
access to the trachea for respiratory support. For the most part, 
tracheostomy tubes are used for this purpose but a tracheal stoma stent can 
offer a suitable alternative in selected cases and deserves wider 
recognition. Methods: Following completion of a patient questionnaire 
survey, the authors describe the use of stoma stents in nine patients, five 
of whom had full-time diaphragm pacing. The stent in these cases is for 
retention of access for positive pressure ventilation, and for the 
prevention of obstructive sleep apnoea. This was also the indication in one 
self-ventilating patient with tetraplegia and sleep apnoea. Two patients 
with recurrent chest infections, in whom chest physiotherapy was difficult, 
benefited from the stoma stents. One patient, after ventilator weaning, 
required a further 4 months of tracheal access on account of episodic 
hypoventilation and temporarily had a tracheal stent as an inpatient. 
Conclusion: Patients who have had the benefit of tracheal stents report 
significant improvement in relation to local discomfort, tracheobronchial 
secretions and vocalization. With suitable training, the stents can be 
changed and cleaned easily in the home setting. © 2008 International Spinal 
Cord Society All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (surgery); stent; stoma stent; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; assisted ventilation; breathing exercise; chest infection; clinical article; diaphragm; health survey; human; hypoventilation; priority journal; quadriplegia; questionnaire; recurrent infection; sleep disordered breathing; trachea; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009011487
MEDLINE PMID
  18347606 (http://www.ncbi.nlm.nih.gov/pubmed/18347606)
PUI
  L354034965
DOI
  10.1038/sc.2008.18
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.2008.18
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.2008.18&atitle=The+use+of+tracheal+stoma+stents+in+high+spinal+cord+injury%3A+A+patient-friendly+alternative+to+long-term+tracheostomy+tubes&stitle=Spinal+Cord&title=Spinal+Cord&volume=46&issue=11&spage=753&epage=755&aulast=Hall&aufirst=A.M.&auinit=A.M.&aufull=Hall+A.M.&coden=SPCOF&isbn=&pages=753-755&date=2008&auinit1=A&auinitm=M
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 802
TITLE
  Case 138: Idiopathic spinal cord herniation(1)
AUTHOR NAMES
  Gandhi D.; Goyal M.; Bourque P.R.
AUTHOR ADDRESSES
  (Gandhi D., dheeraj@umich.edu; Goyal M.) Departments of Diagnostic Imaging, 
Ottawa Hospital, Civic Campus, Ottawa, ON, Canada.
(Bourque P.R.) Department of Neurology, Ottawa Hospital, Civic Campus, 
Ottawa, ON, Canada.
(Gandhi D., dheeraj@umich.edu) Divisions of Interventional and Diagnostic 
Neuroradiology, Department of Radiology, University of Michigan Hospitals, 
UH-B2- A209, 1500 E Medical Center Dr, Ann Arbor, MI 48105-0030.
CORRESPONDENCE ADDRESS
  D. Gandhi, Divisions of Interventional and Diagnostic Neuroradiology, 
Department of Radiology, University of Michigan Hospitals, UH-B2- A209, 1500 
E Medical Center Dr, Ann Arbor, MI 48105-0030. Email: dheeraj@umich.edu
FULL RECORD ENTRY DATE
  2009-04-02
SOURCE
  Radiology (2008) 249:1 (384-388). Date of Publication: October 2008
VOLUME
  249
ISSUE
  1
FIRST PAGE
  384
LAST PAGE
  388
DATE OF PUBLICATION
  October 2008
ISSN
  0033-8419
  1527-1315 (electronic)
BOOK PUBLISHER
  Radiological Society of North America Inc., 820 Jorie Boulevard, Oak Brook, 
United States.
ABSTRACT
  History A 66-year-old woman presented with numbness in the anteromedial 
aspect of her right thigh and difficulty with right leg movement for the 
past year. She did not have back pain or lower limb pain, nor did she have a 
history of relevant trauma. At the time of presentation, her arterial 
hypertension and osteoarthritis were being treated. She had a history of 
localized laryngeal amyloidosis, which was found at 30 years of age and 
treated with laser excision and tracheostomy. Physical examination revealed 
mild spasticity and impaired pain and temperature sensation in the right 
leg. She underwent magnetic resonance (MR) imaging, myelography, and 
postmyelography computed tomography (CT) of the thoracic spine. © RSNA, 
2008.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hernia (diagnosis); idiopathic disease (diagnosis); spinal cord disease (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  aged; anamnesis; case report; clinical feature; computer assisted tomography; female; human; myelography; nuclear magnetic resonance imaging; physical examination; priority journal; review; spasticity (diagnosis); thoracic spine; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009134252
MEDLINE PMID
  18796690 (http://www.ncbi.nlm.nih.gov/pubmed/18796690)
PUI
  L354333603
DOI
  10.1148/radiol.2491020676
FULL TEXT LINK
  http://dx.doi.org/10.1148/radiol.2491020676
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00338419&id=doi:10.1148%2Fradiol.2491020676&atitle=Case+138%3A+Idiopathic+spinal+cord+herniation1&stitle=Radiology&title=Radiology&volume=249&issue=1&spage=384&epage=388&aulast=Gandhi&aufirst=Dheeraj&auinit=D.&aufull=Gandhi+D.&coden=RADLA&isbn=&pages=384-388&date=2008&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 803
TITLE
  Median labiomandibular glossotomy approach to the craniocervical region
AUTHOR NAMES
  Brookes J.T.; Smith R.J.H.; Menezes A.H.; Smith M.C.
AUTHOR ADDRESSES
  (Brookes J.T.; Smith M.C.) Department of Otolaryngology Head and Neck 
Surgery, University of Iowa Hospitals and Clinics, Iowa, IA, United States.
(Smith R.J.H.) Department of Otolaryngology Head and Neck Surgery, 200 
Hawkins Drive, 21201 PFP, Iowa City, IA 52242, United States.
(Menezes A.H., arnold-menezes@uiowa.edu) Department of Neurosurgery, 
University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 
52242, United States.
CORRESPONDENCE ADDRESS
  A.H. Menezes, Department of Neurosurgery, University of Iowa Hospitals and 
Clinics, 200 Hawkins Drive, Iowa City, IA 52242, United States. Email: 
arnold-menezes@uiowa.edu
FULL RECORD ENTRY DATE
  2008-09-30
SOURCE
  Child's Nervous System (2008) 24:10 (1195-1201). Date of Publication: 2008
  The craniocervical junction and its abnormalities, Book Series Title:
VOLUME
  24
ISSUE
  10
FIRST PAGE
  1195
LAST PAGE
  1201
DATE OF PUBLICATION
  2008
ISSN
  0256-7040
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Introduction: In children as well as adults, adequate access to the 
craniocervical junction and upper cervical vertebra can usually be achieved 
with a transoral-transpalatopharyngeal route. However, when access is 
necessary to achieve the C5 level and the upper cervical spine in children, 
this is very difficult. This is particularly so when the incisor opening is 
less than 2.5 cm. The median labiomandibular glossotomy provides such an 
approach. Materials and methods: Our experience with five children is 
presented in a representative case: a 4-year-old male with a family history 
of spondyloepiphyseal dysplasia presented with mild quadriparesis, 2 years 
earlier. This had rapid progression with severe upper cervical kyphosis. A 
standard transoral-transpalatopharyngeal approach or a lateral 
extrapharyngeal approach would not achieve exposure of the pathology. Hence, 
a median labiomandibular glossotomy was utilized for ventral decompression 
with an anterior interbody fusion between C2 and C4. Crown halo cervical 
traction was placed intraoperatively before a tracheostomy and 
tonsillectomy. A median labiomandibular glossotomy was then made with 
resection of the displaced odontoid process and the vertebral bodies of C3 
and C4. This was followed by an anterior interbody fusion between the C2 and 
C4 vertebrae with costal rib grafts. Result and conclusion: He was 
successfully decannulated during the second postoperative week upon 
resolution of lingual edema. A planned staged dorsal occipitocervical fusion 
was performed 6 months later, at which time the ventral fusion was quite 
solid. He had full neurological recovery. © Springer-Verlag 2008.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantooccipital joint; median labiomandibular glossotomy; surgical approach; 
EMTREE MEDICAL INDEX TERMS
  anterior spine fusion; article; brace; case report; cervical spine; clinical feature; decompression surgery; disease course; disease severity; family history; follow up; human; kyphosis (complication); male; odontoid process; peroperative care; postoperative care; postoperative period; preschool child; priority journal; quadriplegia; rib graft; spinal cord compression (surgery, therapy); spondyloepiphyseal dysplasia (surgery, therapy); surgical technique; tonsillectomy; tracheostomy; traction therapy; treatment indication; treatment response; vertebra body; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008436421
MEDLINE PMID
  18437393 (http://www.ncbi.nlm.nih.gov/pubmed/18437393)
PUI
  L50131840
DOI
  10.1007/s00381-008-0609-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-008-0609-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-008-0609-5&atitle=Median+labiomandibular+glossotomy+approach+to+the+craniocervical+region&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=24&issue=10&spage=1195&epage=1201&aulast=Brookes&aufirst=James+T.&auinit=J.T.&aufull=Brookes+J.T.&coden=CNSYE&isbn=&pages=1195-1201&date=2008&auinit1=J&auinitm=T
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 804
TITLE
  Surgical approaches: Postoperative care and complications 
"posterolateral-far lateral transcondylar approach to the ventral foramen 
magnum and upper cervical spinal canal"
AUTHOR NAMES
  Menezes A.H.
AUTHOR ADDRESSES
  (Menezes A.H., arnold-menezes@uiowa.edu) Department of Neurosurgery, 
University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 
52242, United States.
CORRESPONDENCE ADDRESS
  A.H. Menezes, Department of Neurosurgery, University of Iowa Hospitals and 
Clinics, 200 Hawkins Drive, Iowa City, IA 52242, United States. Email: 
arnold-menezes@uiowa.edu
FULL RECORD ENTRY DATE
  2008-09-24
SOURCE
  Child's Nervous System (2008) 24:10 (1203-1207). Date of Publication: 2008
  The craniocervical junction and its abnormalities, Book Series Title:
VOLUME
  24
ISSUE
  10
FIRST PAGE
  1203
LAST PAGE
  1207
DATE OF PUBLICATION
  2008
ISSN
  0256-7040
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Background: Lesions that affect the lower clivus, foramen magnum, the 
craniocervical junction, and the upper cervical spinal canal that are 
anterolateral and at times intradural require access ventral to the 
cerebellum and spinal cord. The posterolateral transcondylar approach 
provides such a route. In addition, posterior craniocervical stabilization 
can be accomplished at the same time. The author has reviewed the technique 
as well as the surgical results here. Materials and methods: The 
posterolateral transcondylar approach to the craniocervical junction was 
utilized in children with schwannoma, meningioma, and chordoma affecting the 
cervicomedullary junction. Other entities such as neurenteric cysts and 
hemangioblastoma were also seen. Extradural tumors such as aneurysmal bone 
cysts of the atlas and the axis vertebrae as well as proatlas segmentation 
abnormalities and bone tumors were seen. The stability of the craniocervical 
junction was assessed preoperatively so that a fusion procedure could be 
accomplished at the same operative setting, if necessary. Preoperative 
evaluation of the lower cranial nerves was vital. The surgical procedure was 
accomplished in the prone position. The occipital bone removal was carried 
out up to the sigmoid sinus and toward the jugular bulb. Relocation of the 
vertebral artery was made at the atlas vertebra and thus provided 
posterolateral exposure into the posterior fossa and upper cervical spinal 
canal. Occipital condyle removal was limited to one-third of the medial 
occipital condyle. Results: Twenty-five children underwent a posterolateral 
transcondylar approach. New lower cranial nerve dysfunction occurred in two 
and only one required a tracheostomy. This was seen in a child with clivus 
chordoma. A complete removal was accomplished in meningioma and schwannoma 
as well as in neurenteric cyst and hemangioblastoma. Clivus chordomas 
required more than one surgical procedure. The tumors of the bone were all 
treated with simultaneous fusion. Conclusions: The posterolateral 
transcondylar route is a versatile avenue to approach a variety of lesions 
ventrolateral to the brain stem and upper cervical cord. Exposure is quite 
satisfactory with minimal or no retraction of important neurovascular 
structures in the region. Modifications of this theme can be applied as the 
lesions require. © Springer-Verlag 2008.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  postoperative care; spine tumor (diagnosis, surgery); surgical approach; 
EMTREE MEDICAL INDEX TERMS
  aneurysmal bone cyst (diagnosis, surgery); article; atlantooccipital joint; body position; bone tumor (diagnosis, surgery); brain stem; cervical spinal cord; cervical spine; child; chordoma (diagnosis, surgery); clinical article; clivus; computer assisted tomography; cranial nerve paralysis (complication); first cervical vertebra; foramen magnum; hemangioblastoma (diagnosis, surgery); human; joint stability; meningioma (diagnosis, surgery); neurilemoma (diagnosis, surgery); nuclear magnetic resonance imaging; occipital bone; posterior fossa; postoperative complication (complication); preoperative evaluation; priority journal; spine fusion; spine stabilization; surgical technique; tracheostomy; treatment response; vertebral artery; vertebral canal; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008436422
MEDLINE PMID
  18365213 (http://www.ncbi.nlm.nih.gov/pubmed/18365213)
PUI
  L50102805
DOI
  10.1007/s00381-008-0597-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00381-008-0597-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02567040&id=doi:10.1007%2Fs00381-008-0597-5&atitle=Surgical+approaches%3A+Postoperative+care+and+complications+%22posterolateral-far+lateral+transcondylar+approach+to+the+ventral+foramen+magnum+and+upper+cervical+spinal+canal%22&stitle=Child%27s+Nerv.+Syst.&title=Child%27s+Nervous+System&volume=24&issue=10&spage=1203&epage=1207&aulast=Menezes&aufirst=Arnold+H.&auinit=A.H.&aufull=Menezes+A.H.&coden=CNSYE&isbn=&pages=1203-1207&date=2008&auinit1=A&auinitm=H
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 805
TITLE
  Slow ventilator weaning after cervical spinal cord injury
AUTHOR NAMES
  Atito-Narh E.; Pieri-Davies S.; Watt J.W.H.
AUTHOR ADDRESSES
  (Atito-Narh E.) Department of Anaesthesia, Southport and Ormskirk Hospital 
NHS Trust, Southport.
(Pieri-Davies S.; Watt J.W.H., John.Watt@southportandormskirk.nhs.uk) North 
West Regional Spinal Injuries Centre, Southport and Ormskirk Hospital NHS 
Trust, Southport.
(Watt J.W.H., John.Watt@southportandormskirk.nhs.uk) North West Regional 
Spinal Injuries Centre, Southport Hospital, Town Lane, Southport, PR8 6PN.
CORRESPONDENCE ADDRESS
  J. W. H. Watt, North West Regional Spinal Injuries Centre, Southport 
Hospital, Town Lane, Southport, PR8 6PN. Email: 
John.Watt@southportandormskirk.nhs.uk
FULL RECORD ENTRY DATE
  2009-01-23
SOURCE
  British Journal of Intensive Care (2008) 18:3 (95-102). Date of Publication: 
Autumn 2008
VOLUME
  18
ISSUE
  3
FIRST PAGE
  95
LAST PAGE
  102
DATE OF PUBLICATION
  Autumn 2008
ISSN
  0961-7930
BOOK PUBLISHER
  Greycoat Publishing, 120 Dawes Road, London, United Kingdom.
ABSTRACT
  Aim: The aim of the cross-sectional study was to look for factors leading to 
success in ventilator weaning after acute spinal cord injury. Methods: 
Referrals to the North West Regional Spinal injuries Centre over a 12-year 
period were reviewed for patients ventilated for >21 days before referral 
and who had been deemed to have failed to wean. Of 126 patients referred, 13 
had already been ventilated for 102 days mean. After referral they were 
weaned in 56 days mean by progressive ventilator-free breathing. Average 
vital capacity improved from 525 to 1415 ml. Despite bacteriological 
colonisation, antibiotic therapy was required in only four cases following 
the transfer. Results: The consistent factors underpinning successful 
weaning after spinal cord damage were accurate neurological assessment; 
prevention of pulmonary atelectasis by physiotherapy; ventilator-free 
breathing graduated according to vital capacity; rest periods with 
controlled ventilation; cuff deflation with translaryngeal air flow, and 
regular tracheostomy tube changes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; atelectasis (complication, prevention, therapy); bacterial colonization; female; human; larynx; major clinical study; male; physiotherapy; tracheostomy; vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008596928
PUI
  L352827906
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09617930&id=doi:&atitle=Slow+ventilator+weaning+after+cervical+spinal+cord+injury&stitle=Br.+J.+Intensive+Care&title=British+Journal+of+Intensive+Care&volume=18&issue=3&spage=95&epage=102&aulast=Atito-Narh&aufirst=&auinit=E.&aufull=Atito-Narh+E.&coden=BJICE&isbn=&pages=95-102&date=2008&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 806
TITLE
  Abnormalities of respiratory control and the respiratory motor unit
AUTHOR NAMES
  Nogués M.A.; Benarroch E.
AUTHOR ADDRESSES
  (Nogués M.A., mnogues@fleni.org.ar) Department of Neurology, Instituto de 
Investigaciones Neurologicas Raul Carrea (FLENI), Buenos Aires, Argentina.
(Benarroch E.) Department of Neurology, Mayo Clinic, Rochester, MN.
(Nogués M.A., mnogues@fleni.org.ar) Departamento de Neurofisiología, 
(FLENI), Instituto Investigaciones Neurológicas Raúl Carrea, Montañeses 
2325, C1428AQK-Buenos Aires, Argentina.
CORRESPONDENCE ADDRESS
  M. A. Nogués, Departamento de Neurofisiología, (FLENI), Instituto 
Investigaciones Neurológicas Raúl Carrea, Montañeses 2325, C1428AQK-Buenos 
Aires, Argentina. Email: mnogues@fleni.org.ar
FULL RECORD ENTRY DATE
  2008-11-10
SOURCE
  Neurologist (2008) 14:5 (273-288). Date of Publication: September 2008
VOLUME
  14
ISSUE
  5
FIRST PAGE
  273
LAST PAGE
  288
DATE OF PUBLICATION
  September 2008
ISSN
  1074-7931
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background: Control of ventilation depends on a brainstem neuronal network 
that controls activity of the motor neurons innervating the respiratory 
muscles. This network includes the pontine respiratory group and the dorsal 
and ventral respiratory groups in the medulla. Neurologic disorders 
affecting these areas or the respiratory motor unit may lead to abnormal 
breathing. Review Summary: The brainstem respiratory network contains 
neurons critical for respiratory rhythmogenesis; this network receives 
inputs from peripheral and central chemoreceptors sensitive to levels of 
carbon dioxide (PaCO(2)) and oxygen (PaO(2)) and from forebrain structures 
that control respiration as part of integrated behaviors such as speech or 
exercise. Manifestations associated with disorders of this network include 
sleep apnea and dysrhythmic breathing frequently associated with 
disturbances of cardiovagal and sympathetic vasomotor control. Common 
disorders associated with impaired cardiorespiratory control include 
brainstem stroke or compression, syringobulbia, Chiari malformation, high 
cervical spinal cord injuries, and multiple system atrophy. By far, 
neuromuscular disorders are the more common neurologic conditions leading to 
respiratory failure. Conclusions: Respiratory dysfunction constitute an 
early and relatively major manifestation of several neurologic disorders and 
may be due to an abnormal breathing pattern generation due to involvement of 
the cardiorespiratory network or more frequently to respiratory muscle 
weakness. Copyright © 2008 by Lippincott Williams & Wilkins.
EMTREE DRUG INDEX TERMS
  carbon dioxide; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  motor unit; respiratory failure (therapy); respiratory function; 
EMTREE MEDICAL INDEX TERMS
  abdominal wall musculature; acute respiratory failure (therapy); amyotrophic lateral sclerosis; Arnold Chiari malformation; artificial ventilation; bethlem myopathy; body weight loss; botulism; brain stem; breathing muscle; breathing pattern; carbon dioxide tension; cerebrovascular accident; chemoreceptor; clinical feature; degenerative disease; demyelinating disease; depression; diaphragm paralysis; dysautonomia; dystrophinopathy; Eaton Lambert syndrome; enzyme deficiency; exercise; facioscapulohumeral muscular dystrophy; forebrain; gene mutation; glucan 1,4 alpha glucosidase deficiency; Guillain Barre syndrome; hypoventilation; intensive care unit; intercostal nerve; intoxication; intubation; limb girdle muscular dystrophy; lung ventilation; motoneuron; muscle disease; muscular dystrophy; myasthenia gravis; myopathy; myotonic dystrophy; nerve cell; nerve cell network; nerve fiber; neuromuscular disease; neuromuscular transmission; noninvasive positive pressure ventilation; nuclear magnetic resonance imaging; oculopharyngeal muscular dystrophy; oxygen tension; Parkinson disease; parkinsonism; pathophysiology; periodic paralysis; phrenic nerve; physiology; poliomyelitis; polyneuropathy; positive end expiratory pressure; positron emission tomography; priority journal; respiration control; respiratory distress (therapy); respiratory tract disease; review; Shy Drager syndrome; sleep disordered breathing; speech; spinal cord; spinal cord compression; spinal cord injury; spinal muscular atrophy; sudden infant death syndrome; supine position; syringomyelia; tracheostomy; vasomotor reflex; vital capacity; white matter; 
CAS REGISTRY NUMBERS
  carbon dioxide (124-38-9, 58561-67-4)
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008474545
MEDLINE PMID
  18784597 (http://www.ncbi.nlm.nih.gov/pubmed/18784597)
PUI
  L352482617
DOI
  10.1097/NRL.0b013e318173e830
FULL TEXT LINK
  http://dx.doi.org/10.1097/NRL.0b013e318173e830
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10747931&id=doi:10.1097%2FNRL.0b013e318173e830&atitle=Abnormalities+of+respiratory+control+and+the+respiratory+motor+unit&stitle=Neurologist&title=Neurologist&volume=14&issue=5&spage=273&epage=288&aulast=Nogu%C3%A9s&aufirst=Mart%C3%ADn+A.&auinit=M.A.&aufull=Nogu%C3%A9s+M.A.&coden=NROLF&isbn=&pages=273-288&date=2008&auinit1=M&auinitm=A
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 807
TITLE
  Therapy of X-linked adrenoleukodystrophy
AUTHOR NAMES
  Semmler A.; Köhler W.; Jung H.H.; Weller M.; Linnebank M.
AUTHOR ADDRESSES
  (Semmler A.; Jung H.H.; Weller M.; Linnebank M., michael.linnebank@usz.ch) 
University Hospital Zürich, Department of Neurology, Frauenklinikstr. 26, 
CH-8091 Zürich, Switzerland.
(Köhler W.) Fachkrankenhaus Hubertusburg, Neurology, Wermsdorf, Germany.
CORRESPONDENCE ADDRESS
  M. Linnebank, University Hospital Zürich, Department of Neurology, 
Frauenklinikstr. 26, CH-8091 Zürich, Switzerland. Email: 
michael.linnebank@usz.ch
FULL RECORD ENTRY DATE
  2008-10-23
SOURCE
  Expert Review of Neurotherapeutics (2008) 8:9 (1367-1379). Date of 
Publication: September 2008
VOLUME
  8
ISSUE
  9
FIRST PAGE
  1367
LAST PAGE
  1379
DATE OF PUBLICATION
  September 2008
ISSN
  1473-7175
  1744-8360 (electronic)
BOOK PUBLISHER
  Expert Reviews Ltd., 2 Albert Place, London, United Kingdom.
ABSTRACT
  X-linked adrenoleukodystrophy (X-ALD; OMIM #300100) is caused by defects of 
the ABCD1 gene on chromosome Xq28, resulting in an impairment of peroxisomal 
β-oxidation and the accumulation of saturated very long chain fatty acids 
(VLCFAs). Primary manifestations occur in the CNS, the adrenal cortex and 
the testes' Leydig cells. The clinical presentation shows a marked 
variability which is not explained by the different X-ALD genotypes. 
Phenotypes range from rapidly progressive cerebral disease with childhood 
(childhood cerebral ALD [CCALD]) or adulthood (adult cerebral ALD [ACALD]) 
onset leading to death within a few years, over adult-onset 
adrenomyeloneuropathy (AMN) with or without focal CNS demyelination, AMN 
converting into a rapidly progressive, cerebral demyelinating phenotype 
resembling CCALD, to slow disease progression over decades, or adrenal 
insufficiency only. Approximately 50% of female heterozygotes develop 
moderate spastic paresis resembling the AMN phenotype. This review focuses 
on current experiences with different therapeutic approaches. Lorenzo's oil 
did not prove to be effective in cerebral inflammatory disease variants, but 
asymptomatic patients, and speculatively AMN variants without cerebral 
involvement, as well as female carriers may benefit from early intake of 
oleic and erucic acids in addition to VLCFA restriction. Hormone-replacement 
therapy is necessary in all patients with adrenal insufficiency. 
Hematopoietic stem cell transplantation has been reported to be effective in 
presymptomatic or early symptomatic CCALD, and may well also be a final 
therapeutic option in early ACALD patients. Early detection of mutation 
carriers and timely initiation of therapy is important for the effectiveness 
of all therapeutic efforts. Gene therapy of endogenous hematopoietic stem 
cells, pharmacological upregulation of other genes encoding proteins 
involved in peroxisomal β-oxidation, reduction of oxidative stress, and 
possibly lovastatin are candidates for future X-ALD therapies. © 2008 Expert 
Reviews Ltd.
EMTREE DRUG INDEX TERMS
  4 phenylbutyric acid (drug therapy); ABC transporter (endogenous compound); ABC transporter D1 (endogenous compound); ABC transporter D2 (endogenous compound); acetylcysteine (drug therapy); alpha tocopherol; ascorbic acid; beta interferon (drug therapy); cyclophosphamide (drug therapy); erucic acid (drug therapy); glucocorticoid (drug therapy); hydroxymethylglutaryl coenzyme A reductase inhibitor (drug therapy); immunoglobulin (drug therapy, intravenous drug administration); Lorenzo oil (adverse drug reaction, clinical trial, drug therapy); mevinolin (drug therapy, pharmacology); mineralocorticoid (drug therapy); oleic acid (drug therapy); placebo; sildenafil (drug therapy); snake venom (drug therapy); unclassified drug; very long chain fatty acid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adrenoleukodystrophy (diagnosis, drug therapy, etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  Addison disease; adrenal insufficiency (therapy); anemia (side effect); artificial ventilation; clinical trial; diagnostic error; diet restriction; DNA polymorphism; drug efficacy; encephalitis; endocrine function; fatty acid oxidation; gastrointestinal symptom (side effect); gene expression; gene mapping; gene mutation; gene therapy; genetic counseling; genotype phenotype correlation; gingivitis (side effect); graft versus host reaction; hematopoietic stem cell transplantation; hormone substitution; human; impotence (complication); leukopenia (side effect); multiple sclerosis (diagnosis); nonhuman; nuclear magnetic resonance imaging; pathophysiology; review; side effect (side effect); social support; spinal cord atrophy; spinal cord injury (drug therapy); thrombocytopenia (side effect); tracheotomy; 
CAS REGISTRY NUMBERS
  acetylcysteine (616-91-1)
  alpha tocopherol (1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9)
  ascorbic acid (134-03-2, 15421-15-5, 50-81-7)
  cyclophosphamide (50-18-0)
  erucic acid (112-86-7)
  immunoglobulin (9007-83-4)
  mevinolin (75330-75-5)
  oleic acid (112-80-1, 115-06-0)
  sildenafil (139755-83-2)
  snake venom (55230-69-8)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Neurology and Neurosurgery (8)
  Human Genetics (22)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008422439
MEDLINE PMID
  18759549 (http://www.ncbi.nlm.nih.gov/pubmed/18759549)
PUI
  L352289187
DOI
  10.1586/14737175.8.9.1367
FULL TEXT LINK
  http://dx.doi.org/10.1586/14737175.8.9.1367
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14737175&id=doi:10.1586%2F14737175.8.9.1367&atitle=Therapy+of+X-linked+adrenoleukodystrophy&stitle=Expert+Rev.+Neurother.&title=Expert+Review+of+Neurotherapeutics&volume=8&issue=9&spage=1367&epage=1379&aulast=Semmler&aufirst=Alexander&auinit=A.&aufull=Semmler+A.&coden=ERNXA&isbn=&pages=1367-1379&date=2008&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 808
TITLE
  Upper airway obstruction after cervical spine fusion surgery: Role of 
cervical fixation angle
AUTHOR NAMES
  Lee Y.-H.; Hsieh P.-F.; Huang H.-H.; Chang K.-C.
AUTHOR ADDRESSES
  (Lee Y.-H.; Hsieh P.-F.; Huang H.-H.; Chang K.-C., jkj@ane1.mc.ntu.edu.tw) 
Department of Anesthesiology, National Taiwan University Hospital, 7 Chung 
Shan South Road, Taipei 100, Taiwan.
CORRESPONDENCE ADDRESS
  K.-C. Chan, Department of Anesthesiology, National Taiwan University 
Hospital, 7 Chung Shan South Road, Taipei 100, Taiwan. Email: 
jkj@ane1.mc.ntu.edu.tw
FULL RECORD ENTRY DATE
  2008-10-31
SOURCE
  Acta Anaesthesiologica Taiwanica (2008) 46:3 (134-137). Date of Publication: 
September 2008
VOLUME
  46
ISSUE
  3
FIRST PAGE
  134
LAST PAGE
  137
DATE OF PUBLICATION
  September 2008
ISSN
  1875-4597
BOOK PUBLISHER
  Elsevier Taiwan LLC, 96 Chung Shan North Road, Section 2, Suite N-412,, 4th 
floor, Chia Hsin Cement Building, Taipei, Taiwan.
ABSTRACT
  Upper airway obstruction is one of the life-threatening events in cervical 
spine surgery. The risk is particularly great during the period immediately 
after operation. We present the case of a 56-year-old female with breast 
cancer and metastasis to the cervical spine. The surgical procedure involved 
C2-C3 laminectomy, posterior fixation (C0-C5), and C2 neurectomy. Tracheal 
extubation was carried out in the intensive care unit, and upper airway 
obstruction immediately followed. Emergency cricothyrotomy was performed 
under well-managed ventilation with a laryngeal mask after several failed 
intubation attempts. Over-flexion of the cervical spine fixation and severe 
prevertebral soft tissue swelling were the most probable causes of upper 
airway obstruction. With a well-adjusted angle for fixation of the cervical 
spine under fluoroscopic guidance before the procedure, such a surgical 
mishap could be avoided. Reintubation with a fiberscope might be considered 
first, and sustaining intubation for 2-3 days postoperatively could be safer 
in such high risk patients. © 2008 Taiwan Society of Anesthesiologists.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; spine fusion; upper respiratory tract obstruction (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; breast cancer (surgery); case report; clinical feature; disease severity; emergency surgery; extubation; female; general anesthesia; human; laminectomy; laryngeal mask; mastectomy; nasotracheal intubation; neurectomy; nuclear magnetic resonance imaging; oxygen saturation; soft tissue disease (complication); spine metastasis (complication, diagnosis, surgery); surgical approach; tracheotomy; 
EMBASE CLASSIFICATIONS
  Cancer (16)
  Arthritis and Rheumatism (31)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008499832
MEDLINE PMID
  18809525 (http://www.ncbi.nlm.nih.gov/pubmed/18809525)
PUI
  L352553323
DOI
  10.1016/S1875-4597(08)60008-9
FULL TEXT LINK
  http://dx.doi.org/10.1016/S1875-4597(08)60008-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=18754597&id=doi:10.1016%2FS1875-4597%2808%2960008-9&atitle=Upper+airway+obstruction+after+cervical+spine+fusion+surgery%3A+Role+of+cervical+fixation+angle&stitle=Acta+Anaesthesiol.+Taiwan.&title=Acta+Anaesthesiologica+Taiwanica&volume=46&issue=3&spage=134&epage=137&aulast=Lee&aufirst=Yi-Hui&auinit=Y.-H.&aufull=Lee+Y.-H.&coden=AATCC&isbn=&pages=134-137&date=2008&auinit1=Y&auinitm=-H
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 809
TITLE
  Successful surgical management of a delayed pharyngo-esophageal perforation 
after anterior cervical spine plating
AUTHOR NAMES
  Solerio D.; Ruffini E.; Gargiulo G.; Camandona M.; Raggio E.; Solini A.; Dei Poli M.
AUTHOR ADDRESSES
  (Solerio D., soleriod@libero.it; Camandona M.; Raggio E.; Dei Poli M.) 
General Surgery 3, San Giovanni Battista Hospital, University of Turin, via 
Genova 3, Turin 10126, Italy.
(Ruffini E.) Thoracic Surgery, San Giovanni Battista Hospital, University of 
Turin, Turin, Italy.
(Gargiulo G.; Solini A.) Orthopaedic Surgery, San Giovanni Battista 
Hospital, University of Turin, Turin, Italy.
CORRESPONDENCE ADDRESS
  D. Solerio, General Surgery 3, San Giovanni Battista Hospital, University of 
Turin, via Genova 3, Turin 10126, Italy. Email: soleriod@libero.it
FULL RECORD ENTRY DATE
  2008-10-01
SOURCE
  European Spine Journal (2008) 17:SUPPL.2 (S280-S284). Date of Publication: 
September 2008
  Case Reports. Accepted between 28 August 2007 and 8 June 2008. Electronic 
only, Book Series Title:
VOLUME
  17
ISSUE
  SUPPL.2
DATE OF PUBLICATION
  September 2008
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  A case report of a 41-year-old man who had a delayed pharyngo-esophageal 
perforation without instrumentation failure 7 years after anterior cervical 
spine plating is presented and the literature on this issue is reviewed. 
This injury resulted from repetitive friction/traction between the 
retropharyngo-esophageal wall and the cervical plate construct leading to a 
pseudodiverticulum and perforation. Successful treatment of the perforation 
was obtained after surgical repair using a sternocleidomastoid muscle flap. 
This case stresses the necessity of careful long-term follow-up in patients 
with anterior cervical spine plating for early detection of possible 
perforation and the use of muscle flap as the treatment of choice during 
surgical repair. © 2008 Springer-Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus perforation (complication, diagnosis, surgery); pharynx disease (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; arthrodesis; article; assisted ventilation; bone plate; bronchus secretion; case report; cervical spine; computer assisted tomography; enteric feeding; esophagoscopy; follow up; human; jejunostomy; male; nasogastric tube; priority journal; sternocleidomastoid muscle; tracheotomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008413443
MEDLINE PMID
  18224356 (http://www.ncbi.nlm.nih.gov/pubmed/18224356)
PUI
  L50046035
DOI
  10.1007/s00586-007-0578-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-007-0578-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-007-0578-5&atitle=Successful+surgical+management+of+a+delayed+pharyngo-esophageal+perforation+after+anterior+cervical+spine+plating&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=17&issue=SUPPL.2&spage=&epage=&aulast=Solerio&aufirst=Dino&auinit=D.&aufull=Solerio+D.&coden=ESJOE&isbn=&pages=-&date=2008&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 810
TITLE
  Preoperative laryngeal nerve screening for revision anterior cervical spine 
procedures
AUTHOR NAMES
  Paniello R.C.; Martin-Bredahl K.J.; Henkener L.J.; Riew K.D.
AUTHOR ADDRESSES
  (Paniello R.C.; Martin-Bredahl K.J.; Henkener L.J.) Department of 
Otolaryngology-Head and Neck Surgery, Washington University School of 
Medicine, St Louis, MO, United States.
(Riew K.D.) Department of Orthopedic Surgery, Washington University School 
of Medicine, St Louis, MO, United States.
(Paniello R.C.) Dept. of Otolaryngology-Head and Neck Surgery, Washington 
University School of Medicine, 660 S Euclid Ave, Campus Box 8115, St Louis, 
MO 63110, United States.
CORRESPONDENCE ADDRESS
  R. C. Paniello, Dept. of Otolaryngology-Head and Neck Surgery, Washington 
University School of Medicine, 660 S Euclid Ave, Campus Box 8115, St Louis, 
MO 63110, United States.
FULL RECORD ENTRY DATE
  2008-11-12
SOURCE
  Annals of Otology, Rhinology and Laryngology (2008) 117:8 (594-597). Date of 
Publication: August 2008
VOLUME
  117
ISSUE
  8
FIRST PAGE
  594
LAST PAGE
  597
DATE OF PUBLICATION
  August 2008
ISSN
  0003-4894
BOOK PUBLISHER
  Annals Publishing Company, 4507 Laclede Avenue, St. Louis, United States.
ABSTRACT
  Objectives: Anterior cervical spine procedures carry an inherent risk of 
recurrent laryngeal nerve (RLN) injury. Patients with persistent RLN paresis 
may be asymptomatic because of compensation from the opposite side. If such 
patients undergo an opposite-side anterior approach for revision surgery, 
they are at risk for a second RLN injury, creating the potential for 
bilateral vocal fold paresis and possible need for tracheotomy. A program of 
routine screening for laryngeal paresis was implemented for these patients. 
This retrospective study reviews the results of this screening process. 
Methods: Patients referred for preoperative laryngeal nerve screening were 
identified. Their charts were reviewed for the results of the 
videolaryngoscopic examination, and for any recommendations made based on 
the findings. Relevant history and other physical findings were recorded. 
Results: Fifty screening laryngeal examinations were performed in 47 
patients, of whom 31 (66%) had previously undergone a single anterior 
cervical approach procedure, and 16 (34%) had undergone more than one. 
Thirteen of the examinations (26%) revealed abnormal laryngeal findings, 
including paresis or paralysis in 11 cases (22%), of which 5 were 
asymptomatic. The findings resulted in a recommendation of a cervical 
approach from the already-involved side. None of the revision procedures 
resulted in bilateral vocal fold paralysis. The risk of laryngeal nerve 
injury appears to increase as higher cervical levels are approached. 
Conclusions: Minimally symptomatic injuries of the laryngeal nerves from 
prior neck surgery create a potential serious risk of bilateral vocal fold 
paralysis with subsequent procedures. Preoperative laryngeal screening is a 
simple and effective method for reducing this risk. © 2008 Annals Publishing 
Company. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior cervical spine procedure; preoperative laryngeal nerve screening; screening; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; clinical article; female; human; laryngeal nerve paralysis (complication); laryngoscopy; male; nerve paralysis (complication); priority journal; recurrent laryngeal nerve; retrospective study; vocal cord paralysis; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008492752
MEDLINE PMID
  18771076 (http://www.ncbi.nlm.nih.gov/pubmed/18771076)
PUI
  L352537578
DOI
  10.1177/000348940811700808
FULL TEXT LINK
  http://dx.doi.org/10.1177/000348940811700808
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034894&id=doi:10.1177%2F000348940811700808&atitle=Preoperative+laryngeal+nerve+screening+for+revision+anterior+cervical+spine+procedures&stitle=Ann.+Otol.+Rhinol.+Laryngol.&title=Annals+of+Otology%2C+Rhinology+and+Laryngology&volume=117&issue=8&spage=594&epage=597&aulast=Paniello&aufirst=Randal+C.&auinit=R.C.&aufull=Paniello+R.C.&coden=AORHA&isbn=&pages=594-597&date=2008&auinit1=R&auinitm=C
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 811
TITLE
  Diaphragm pacing restores olfaction in tetraplegia
AUTHOR NAMES
  Adler D.; Gonzalez-Bermejo J.; Duguet A.; Demoule A.; Le Pimpec-Barthes F.; Hurbault A.; Morélot-Panzini C.; Similowski T.
AUTHOR ADDRESSES
  (Adler D.; Gonzalez-Bermejo J.; Duguet A.; Demoule A.; Hurbault A.; 
Morélot-Panzini C.; Similowski T., thomas.similowski@psl.ap-hop-paris.fr) 
Service de Pneumologie et Reanimation, Centre de Stimulation Phrenique 
Implantee, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
(Le Pimpec-Barthes F.) APHP, Service de Chirurgie Thoracique, Hôpital 
Européen Georges Pompidou, Paris, France.
(Adler D.; Gonzalez-Bermejo J.; Duguet A.; Demoule A.; Morélot-Panzini C.; 
Similowski T., thomas.similowski@psl.ap-hop-paris.fr) Université Paris 6, ER 
10 UPMC, Paris, France.
(Adler D.) Service de Pneumologie, Hôpital Cantonal Universitaire de Genève, 
Geneva, Switzerland.
CORRESPONDENCE ADDRESS
  T. Similowski, Service de Pneumologie et Reanimation, Centre de Stimulation 
Phrenique Implantee, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. 
Email: thomas.similowski@psl.ap-hop-paris.fr
FULL RECORD ENTRY DATE
  2009-10-13
SOURCE
  European Respiratory Journal (2009) 34:2 (365-370). Date of Publication: 
August 2008
VOLUME
  34
ISSUE
  2
FIRST PAGE
  365
LAST PAGE
  370
DATE OF PUBLICATION
  August 2008
ISSN
  0903-1936
  1399-3003 (electronic)
BOOK PUBLISHER
  European Respiratory Society, 4 Ave Sainte-Luce, Lausanne, Switzerland.
ABSTRACT
  High cervical spinal cord injuries induce extreme handicap and tactile 
isolation. Tracheotomised tetraplegic patients are also bound to be 
olfaction deprived. By restoring negative pressure inspiration, diaphragm 
pacing (DP) should improve olfaction. We tested olfaction in 10 consecutive 
tetraplegics during positive pressure mechanical ventilation and DP, using 
the University of Pennsylvania Smell Identification Test (UPSIT). Quality of 
life was assessed using the Satisfaction with Life Scale (SWLS). 
Self-perceived benefits of DP were studied using an in-house questionnaire. 
Olfaction was very poor during positive pressure mechanical ventilation 
(UPSIT, mean±SD 17.1±6.4, anosmia or severe microsmia). It improved during 
DP (35.2±1.9, normosmia or mild microsmia; p<0.0001) and SWLS was 18.5±4.2. 
Nine patients stated that DP had improved their quality of life. This was 
driven by better mobility (ranked first), improved self-image and 
relationships with others (ranked second), improved olfaction and better 
feeling of security (both ranked third). Improved olfaction is among the 
benefits of DP and should be mentioned to patients considered for this 
therapy. Furthermore, attention to olfaction is warranted in tracheotomised 
ventilator-dependent patients, as a putative path towards improvement of 
quality of life. Copyright©ERS Journals Ltd 2009.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  nerve stimulation; phrenic nerve pacing; quadriplegia (complication, disease management); smelling; 
EMTREE MEDICAL INDEX TERMS
  adult; article; cervical spinal cord injury; clinical article; female; human; human relation; hypothesis; male; mobilization; negative pressure ventilation; phrenic nerve; positive end expiratory pressure; priority journal; quality of life; questionnaire; rating scale; Satisfaction with Life Scale; screening test; self concept; tracheotomy; treatment outcome; University of Pennsylvania Smell Identification Test; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2009453906
MEDLINE PMID
  19251778 (http://www.ncbi.nlm.nih.gov/pubmed/19251778)
PUI
  L355156459
DOI
  10.1183/09031936.00177708
FULL TEXT LINK
  http://dx.doi.org/10.1183/09031936.00177708
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09031936&id=doi:10.1183%2F09031936.00177708&atitle=Diaphragm+pacing+restores+olfaction+in+tetraplegia&stitle=Eur.+Respir.+J.&title=European+Respiratory+Journal&volume=34&issue=2&spage=365&epage=370&aulast=Adler&aufirst=D.&auinit=D.&aufull=Adler+D.&coden=ERJOE&isbn=&pages=365-370&date=2009&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 812
TITLE
  Diagnosis and Clinical Management of Spinal Muscular Atrophy
AUTHOR NAMES
  Han J.J.; McDonald C.M.
AUTHOR ADDRESSES
  (Han J.J., jay.han@ucdmc.ucdavis.edu; McDonald C.M.) Department of Physical 
Medicine and Rehabilitation, University of California-Davis, 4860 Y Street, 
Suite 3850, Sacramento, CA 95817, United States.
CORRESPONDENCE ADDRESS
  J.J. Han, Department of Physical Medicine and Rehabilitation, University of 
California-Davis, 4860 Y Street, Suite 3850, Sacramento, CA 95817, United 
States. Email: jay.han@ucdmc.ucdavis.edu
FULL RECORD ENTRY DATE
  2008-08-20
SOURCE
  Physical Medicine and Rehabilitation Clinics of North America (2008) 19:3 
(661-680). Date of Publication: August 2008
VOLUME
  19
ISSUE
  3
FIRST PAGE
  661
LAST PAGE
  680
DATE OF PUBLICATION
  August 2008
ISSN
  1047-9651
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular 
disease characterized by degeneration of lower motor neurons, with resulting 
progressive muscle weakness. The clinical phenotype and disease severity can 
be varied and occupy a wide spectrum. Although many advances have been made 
regarding our understanding of SMA, no cure is yet available. The care of 
patients who have SMA can often be complex, with many medical issues to 
consider. When possible, a multidisciplinary team approach is effective. The 
current understanding of SMA, and the clinical management and rehabilitative 
care of patients who have SMA, are discussed in this article. © 2008 
Elsevier Inc. All rights reserved.
EMTREE DRUG INDEX TERMS
  calcium; creatine kinase (endogenous compound); vitamin D; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diagnostic procedure; patient care; spinal muscular atrophy (diagnosis, disease management, etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  action potential; artificial ventilation; blood analysis; body composition; bulbar paralysis; cast application; chromosome 5q; clinical examination; clinical feature; conservative treatment; creatine kinase blood level; criterion variable; daily life activity; diagnostic test; diagnostic value; disease activity; disease classification; disease course; disease marker; disease severity; dysphagia; echocardiography; electrocardiogram; electrodiagnosis; electromyography; family counseling; fasciculation; forced expiratory volume; fracture (complication, therapy); functional assessment; functional status; gait disorder; gene deletion; gene frequency; gene identification; gene mutation; genetic counseling; genetic epidemiology; heart disease (diagnosis); heart function; heterozygote; hip contracture (therapy); hip dislocation (complication); histopathology; human; infant feeding; infantile hypotonia; kyphoscoliosis; kyphosis; laboratory diagnosis; laboratory test; life expectancy; limb movement; limb weakness; lung clearance; lung disease (complication, therapy); lung function test; motoneuron; motor nerve conduction; muscle atrophy; muscle biopsy; muscle contracture; muscle exercise; muscle function; muscle strength; muscle weakness (diagnosis, therapy); nerve cell degeneration; newborn assessment; nonhuman; nutritional status; onset age; osteopenia (complication, therapy); patient monitoring; phenotype; physical examination; polysomnography; predictive validity; priority journal; prognosis; psychosocial care; range of motion; rehabilitation; respiratory care; review; scoliosis (surgery); sensitivity and specificity; sleep disordered breathing (diagnosis); spine fusion; spine malformation; spirometry; subluxation; survival; symptomatology; tendon reflex; tracheostomy; treatment contraindication; treatment indication; vitamin supplementation; 
CAS REGISTRY NUMBERS
  calcium (14092-94-5, 7440-70-2)
  creatine kinase (9001-15-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  General Pathology and Pathological Anatomy (5)
  Public Health, Social Medicine and Epidemiology (17)
  Human Genetics (22)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008326788
MEDLINE PMID
  18625423 (http://www.ncbi.nlm.nih.gov/pubmed/18625423)
PUI
  L351952447
DOI
  10.1016/j.pmr.2008.02.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.pmr.2008.02.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10479651&id=doi:10.1016%2Fj.pmr.2008.02.004&atitle=Diagnosis+and+Clinical+Management+of+Spinal+Muscular+Atrophy&stitle=Phys.+Med.+Rehabil.+Clin.+North+Am.&title=Physical+Medicine+and+Rehabilitation+Clinics+of+North+America&volume=19&issue=3&spage=661&epage=680&aulast=Han&aufirst=Jay+J.&auinit=J.J.&aufull=Han+J.J.&coden=PMRAF&isbn=&pages=661-680&date=2008&auinit1=J&auinitm=J
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 813
TITLE
  Sigmoid fixation associated with rectopexy using a laparoscopic approach 
could prevent relapse of rectal prolapse in pediatric patients with spinal 
dysraphia
AUTHOR NAMES
  Montes-Tapia F.; Cura-Esquivel I.; Garza-Luna U.; Martínez-Flores G.; Muñoz-Maldonado G.; Abrego-Moya V.
AUTHOR ADDRESSES
  (Montes-Tapia F., ffmt@yahoo.com; Garza-Luna U.; Martínez-Flores G.; 
Muñoz-Maldonado G.) Pediatric Surgery, Hospital Universitario Dr José E. 
González, Universidad Autónoma de Nuevo León, Madero y Gonzalitos s/n, 
Monterrey, Nuevo León 64460, Mexico.
(Cura-Esquivel I.) Pediatric Gastroenterology, Hospital Universitario Dr 
José E. González, Universidad Autónoma de Nuevo León, Madero y Gonzalitos 
s/n, Monterrey, Nuevo León 64460, Mexico.
(Abrego-Moya V.) Pediatric Department Hospital Universitario Dr José E. 
González, Universidad Autónoma de Nuevo León, Madero y Gonzalitos s/n, 
Monterrey, Nuevo León 64460, Mexico.
CORRESPONDENCE ADDRESS
  F. Montes-Tapia, Pediatric Surgery, Hospital Universitario Dr José E. 
González, Universidad Autónoma de Nuevo León, Madero y Gonzalitos s/n, 
Monterrey, Nuevo León 64460, Mexico. Email: ffmt@yahoo.com
FULL RECORD ENTRY DATE
  2008-08-28
SOURCE
  Journal of Pediatric Surgery (2008) 43:8 (1551-1553). Date of Publication: 
August 2008
VOLUME
  43
ISSUE
  8
FIRST PAGE
  1551
LAST PAGE
  1553
DATE OF PUBLICATION
  August 2008
ISSN
  0022-3468
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Recurrent rectal prolapse, resistant to medical treatment, is an indication 
for surgical treatment. Patients with spinal dysraphia frequently have 
already been treated by sclerotherapy or other surgical techniques, but 
unsuccessfully. Methods: We present 2 patients, who underwent laparoscopic 
rectopexy, with spinal dysraphia and complete rectal prolapse relapse after 
conservative treatment. In these patients, we performed, as an additional 
technique, fixation of the rectosigmoid to avoid recurrence by invagination 
or prolapse of the anterior wall. Results: Follow-up at 14 and 11 months, 
respectively, did not find any recurrence. Conclusion: We suggest that 
laparoscopic rectopexy with sigmoid fixation should be considered as an 
alternative for the treatment for patients with spinal dysraphia and rectal 
prolapse to avoid recurrence. © 2008 Elsevier Inc. All rights reserved.
EMTREE DRUG INDEX TERMS
  laxative; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gastrointestinal surgery; rectosigmoid fixation; rectum prolapse (complication, congenital disorder, surgery); spinal dysraphism (congenital disorder, etiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  Arnold Chiari malformation (congenital disorder, diagnosis); article; bone radiography; case report; childhood disease; conservative treatment; diet therapy; follow up; human; invagination (complication); laparoscopic surgery; male; newborn; priority journal; proctopexy; recurrent disease; stomach fundoplication; surgical technique; thorax radiography; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008360339
MEDLINE PMID
  18675652 (http://www.ncbi.nlm.nih.gov/pubmed/18675652)
PUI
  L352063560
DOI
  10.1016/j.jpedsurg.2008.02.082
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jpedsurg.2008.02.082
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223468&id=doi:10.1016%2Fj.jpedsurg.2008.02.082&atitle=Sigmoid+fixation+associated+with+rectopexy+using+a+laparoscopic+approach+could+prevent+relapse+of+rectal+prolapse+in+pediatric+patients+with+spinal+dysraphia&stitle=J.+Pediatr.+Surg.&title=Journal+of+Pediatric+Surgery&volume=43&issue=8&spage=1551&epage=1553&aulast=Montes-Tapia&aufirst=Fernando&auinit=F.&aufull=Montes-Tapia+F.&coden=JPDSA&isbn=&pages=1551-1553&date=2008&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 814
TITLE
  Surface functional electrical stimulation of the abdominal muscles to 
enhance cough and assist tracheostomy decannulation after high-level spinal 
cord injury
AUTHOR NAMES
  Lee B.B.; Boswell-Ruys C.; Butler J.E.; Gandevia S.C.
AUTHOR ADDRESSES
  (Lee B.B., blee@medicalinformatics.net) Prince of Wales Hospital, Sydney, 
NSW, Australia.
(Boswell-Ruys C.; Butler J.E.; Gandevia S.C.) Prince of Wales Medical 
Research Institute, Sydney, NSW, Australia.
(Lee B.B., blee@medicalinformatics.net) Prince of Wales Spinal Medicine 
Department, Prince of Wales Hospital, lvl 2 High Street, Randwick, Sydney, 
NSW 2031, Australia.
CORRESPONDENCE ADDRESS
  B. B. Lee, Prince of Wales Spinal Medicine Department, Prince of Wales 
Hospital, lvl 2 High Street, Randwick, Sydney, NSW 2031, Australia. Email: 
blee@medicalinformatics.net
FULL RECORD ENTRY DATE
  2008-07-18
SOURCE
  Journal of Spinal Cord Medicine (2008) 31:1 (78-82). Date of Publication: 
2008
VOLUME
  31
ISSUE
  1
FIRST PAGE
  78
LAST PAGE
  82
DATE OF PUBLICATION
  2008
ISSN
  1079-0268
BOOK PUBLISHER
  American Paraplegia Society, 75-20 Astoria Boulevard, Jackson Heights, 
United States.
ABSTRACT
  Objective: Evaluation of noninvasive stimulation modalities to augment cough 
and assist tracheostomy decannulation in high-level tetraplegia. Study 
Design: Single case study. Methods: A 65-year-old man with C4 ASIA C 
tetraplegia had delayed rehabilitation due to a tracheostomy and recurrent 
pneumonia primarily resulting from ineffective cough. Anterior surface 
electrical stimulation (SES) of the abdominal musculature was conducted to 
train an effective cough and enable decannulation. Training occurred daily 
for 4 weeks. The patient was tested 1 year later with posterolateral SES to 
determine the relative clinical effect of this delivery method. Results: At 
baseline, the addition of anterior SES increased maximal expiratory pressure 
(80%), maximal expiratory cough pressure (67%), and peak expiratory flow 
rate (11 %). Three weeks after training began, the patient was decannulated 
following a program of SES and assisted and voluntary coughing. Upon testing 
1 year later, SES with posterolaterally placed electrodes also produced an 
enhancement of voluntary cough attempts. Conclusions: Noninvasive SES can 
potentially assist decannulation of tracheostomies. © 2008 by the American 
Paraplegia Society.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  electrostimulation; spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  abdominal wall musculature; adult; article; case report; coughing; decannulation; electrode; human; investigative procedures; male; pneumonia; recurrent disease; rehabilitation care; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008291304
MEDLINE PMID
  18533416 (http://www.ncbi.nlm.nih.gov/pubmed/18533416)
PUI
  L351838100
DOI
  10.1080/10790268.2008.11753985
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2008.11753985
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2008.11753985&atitle=Surface+functional+electrical+stimulation+of+the+abdominal+muscles+to+enhance+cough+and+assist+tracheostomy+decannulation+after+high-level+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=31&issue=1&spage=78&epage=82&aulast=Lee&aufirst=Bonsan+B.&auinit=B.B.&aufull=Lee+B.B.&coden=JSCMC&isbn=&pages=78-82&date=2008&auinit1=B&auinitm=B
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 815
TITLE
  Critical Burn Patient with an Unknown Neuromuscular Disease: Conclusion
AUTHOR NAMES
  Knight IV W.A.; Gunderman M.; Hinckley W.R.
AUTHOR ADDRESSES
  (Knight IV W.A., knightwa@ucmail.uc.edu; Gunderman M.; Hinckley W.R.)
FULL RECORD ENTRY DATE
  2008-08-26
SOURCE
  Air Medical Journal (2008) 27:4 (160-166). Date of Publication: July 
2008/August 2008
VOLUME
  27
ISSUE
  4
FIRST PAGE
  160
LAST PAGE
  166
DATE OF PUBLICATION
  July 2008/August 2008
ISSN
  1067-991X
  1532-6497 (electronic)
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  A 37-year-old man was severely burned while trying to fill a lighter with 
fuel while smoking. He sustained full-thickness (third-degree) burns over 
60% to 70% of his body, including the oropharynx. A ground-based paramedic 
was unable to orotracheally intubate the patient after the administration of 
morphine and diazepam. The flight crew's assessment found an awake, alert 
man who was unable to speak because of his oral injuries. The Glasgow Coma 
Scale was estimated to be 10. In addition, the patient was wheelchair-bound 
from an undefined neuromuscular disease. The patient was successfully 
intubated by the flight team as in the following description. © 2008 Air 
Medical Journal Associates.
EMTREE DRUG INDEX TERMS
  bicarbonate; calcium (drug therapy); cisatracurium; diazepam; etomidate; furosemide; glucose; insulin; morphine; pancuronium; polystyrenesulfonate sodium; rocuronium; salbutamol; suxamethonium (adverse drug reaction); vecuronium (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  burn; endotracheal intubation; neuromuscular disease; 
EMTREE MEDICAL INDEX TERMS
  adult; aircraft; aircraft accident; airway dynamics; article; case report; clinical feature; compartment syndrome (complication); critically ill patient; electrocardiogram; emergency care; environmental temperature; Glasgow coma scale; heart arrhythmia (complication); human; hyperkalemia (drug therapy, side effect); male; paralysis; paramedical personnel; patient care; priority journal; spinal cord injury; spinocerebellar degeneration; tracheotomy; wheelchair; 
CAS REGISTRY NUMBERS
  bicarbonate (144-55-8, 71-52-3)
  calcium (14092-94-5, 7440-70-2)
  cisatracurium (96946-41-7, 96946-42-8)
  diazepam (439-14-5)
  etomidate (15301-65-2, 33125-97-2, 51919-80-3)
  furosemide (54-31-9)
  glucose (50-99-7, 84778-64-3)
  insulin (9004-10-8)
  morphine (52-26-6, 57-27-2)
  polystyrenesulfonate sodium (37349-16-9, 39291-70-8, 62744-35-8, 9080-79-9)
  rocuronium (119302-91-9)
  salbutamol (18559-94-9)
  suxamethonium (306-40-1, 71-27-2)
  vecuronium (50700-72-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Anesthesiology (24)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008312143
MEDLINE PMID
  18603211 (http://www.ncbi.nlm.nih.gov/pubmed/18603211)
PUI
  L351899312
DOI
  10.1016/j.amj.2008.03.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.amj.2008.03.007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1067991X&id=doi:10.1016%2Fj.amj.2008.03.007&atitle=Critical+Burn+Patient+with+an+Unknown+Neuromuscular+Disease%3A+Conclusion&stitle=Air+Med.+J.&title=Air+Medical+Journal&volume=27&issue=4&spage=160&epage=166&aulast=Knight+IV&aufirst=William+A.&auinit=W.A.&aufull=Knight+IV+W.A.&coden=AMJIA&isbn=&pages=160-166&date=2008&auinit1=W&auinitm=A
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 816
TITLE
  Rigid spine syndrome: A radiologic and manometric study of the pharynx and 
esophagus
AUTHOR NAMES
  Stübgen J.-P.
AUTHOR ADDRESSES
  (Stübgen J.-P., pstuebge@med.cornell.edu) Department of Neurology, 
University of Pretoria, Pretoria, South Africa.
(Stübgen J.-P., pstuebge@med.cornell.edu) Department of Neurology and 
Neuroscience, Weill Medical College of Cornell University, 525 East 68th 
Street, New York, NY 10021, United States.
CORRESPONDENCE ADDRESS
  J.-P. Stübgen, Department of Neurology and Neuroscience, Weill Medical 
College of Cornell University, 525 East 68th Street, New York, NY 10021, 
United States. Email: pstuebge@med.cornell.edu
FULL RECORD ENTRY DATE
  2008-07-07
SOURCE
  Dysphagia (2008) 23:2 (110-115). Date of Publication: June 2008
VOLUME
  23
ISSUE
  2
FIRST PAGE
  110
LAST PAGE
  115
DATE OF PUBLICATION
  June 2008
ISSN
  0179-051X
BOOK PUBLISHER
  Springer New York, 233 Springer Street, New York, United States.
ABSTRACT
  The rigid spine syndrome (RSS) is not a recognized cause of dysphagia. The 
"vacuolar variant" of RSS causes mild, generalized, and slowly progressive 
weakness. Respiratory evaluation detected severe restrictive chest wall 
defect and significant respiratory muscle weakness. We identified nine 
patients at our Neuromuscular Clinic over a period of years. The aim of this 
evaluation was to ascertain whether pharyngoesophageal dysfunction caused 
cough (2/9), intermittent oropharyngeal dysphagia (4/9), and aspiration 
pneumonia (3/9). Pharyngeal and esophageal functions were evaluated 
separately by conventional cineradiography and intraluminal esophageal 
manometry over a one-year study period. An age- and gender-matched volunteer 
group without swallowing complaints partook in the manometric component of 
the study. There were seven male and two female patients. The mean age of 
patients was 19.1 years (17.8 years for controls), and the age range was 
11-36 years (13-32 years for controls). The mean disease duration was 17.2 
years (range = 8-31 years). Patients were commonly underweight (7/9). 
Cineradiology detected abnormal swallow physiology of pharyngeal striated 
muscle (1/9) and of esophageal smooth muscle (2/9). Mean manometric 
pressures in patients were not significantly different from control data. 
Manometry detected "nonspecific" contractility abnormalities (3/9) that were 
not reflected in the mean data. The relative lack of instrumental findings 
suggested minor upper alimentary tract dysmotility in patients with the RSS. 
The myopathy that underlies this syndrome likely caused dysfunction of the 
striated muscle of the pharyngeal constrictors and upper esophageal 
sphincter. The documented abnormalities of esophageal smooth muscle motility 
were nonspecific and tenuously associated with the muscle disorder. The 
incongruity between complaints of intermittent dysphagia and study results 
was perhaps due to transient pharyngoesophageal dysmotility, altered 
swallowing mechanics of limited cervical spine mobility, altered swallowing 
perception after previous intubation/tracheostomy, or a "functional" upper 
intestinal complaint. © 2007 Springer Science+Business Media, LLC.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cineradiography; dysphagia; myopathy (diagnosis); rigid spine syndrome (diagnosis); thorax radiography; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; age distribution; article; aspiration pneumonia; breathing muscle; clinical article; controlled study; coughing; esophagus function; female; histopathology; human; human tissue; intubation; male; manometry; oropharynx; priority journal; school child; sex ratio; swallowing; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008261642
MEDLINE PMID
  17694409 (http://www.ncbi.nlm.nih.gov/pubmed/17694409)
PUI
  L351754675
DOI
  10.1007/s00455-007-9102-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00455-007-9102-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0179051X&id=doi:10.1007%2Fs00455-007-9102-7&atitle=Rigid+spine+syndrome%3A+A+radiologic+and+manometric+study+of+the+pharynx+and+esophagus&stitle=Dysphagia&title=Dysphagia&volume=23&issue=2&spage=110&epage=115&aulast=St%C3%BCbgen&aufirst=Joerg-Patrick&auinit=J.-P.&aufull=St%C3%BCbgen+J.-P.&coden=DYSPE&isbn=&pages=110-115&date=2008&auinit1=J&auinitm=-P
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 817
TITLE
  Boussignac continuous positive airway pressure for weaning with tracheostomy 
tubes
AUTHOR NAMES
  Dieperink W.; Aarts L.P.H.J.; Rodgers M.G.G.; Delwig H.; Nijsten M.W.N.
AUTHOR ADDRESSES
  (Dieperink W., w.dieperink@chir.umcg.nl; Rodgers M.G.G.; Delwig H.; Nijsten 
M.W.N.) Surgical Intensive Care Unit, University Medical Center Groningen, 
University of Groningen, Groningen, Netherlands.
(Aarts L.P.H.J.) Department of Anesthesiology, University Medical Center 
Groningen, University of Groningen, Groningen, Netherlands.
(Dieperink W., w.dieperink@chir.umcg.nl) Surgical Intensive Care Unit, UMCG, 
PO Box 30.001, NL-9700 RB Groningen, Netherlands.
CORRESPONDENCE ADDRESS
  W. Dieperink, Surgical Intensive Care Unit, UMCG, PO Box 30.001, NL-9700 RB 
Groningen, Netherlands. Email: w.dieperink@chir.umcg.nl
FULL RECORD ENTRY DATE
  2008-07-02
SOURCE
  Respiration (2008) 75:4 (427-431). Date of Publication: May 2008
VOLUME
  75
ISSUE
  4
FIRST PAGE
  427
LAST PAGE
  431
DATE OF PUBLICATION
  May 2008
ISSN
  0025-7931
BOOK PUBLISHER
  S. Karger AG, Allschwilerstrasse 10, P.O. Box, Basel, Switzerland.
ABSTRACT
  Background: In patients who are weaned with a tracheostomy tube (TT), 
continuous positive airway pressure (CPAP) is frequently used. Dedicated 
CPAP systems or ventilators with bulky tubing are usually applied. However, 
CPAP can also be effective without a ventilator by the disposable Boussignac 
CPAP (BCPAP) system that is normally used with face masks. Objective:It was 
the aim of this audit to evaluate the feasibility of low-level BCPAP in 
patients who were weaned with a TT. Methods: All patients at our surgical 
intensive care unit who received a TT for weaning were considered for 
application of BCPAP. Once patients had received minimal pressure support 
from the mechanical ventilator, the BCPAP device was connected to the TT 
three times a day for 30 min with pressure set to 3-5 cm H(2)O, FiO(2) at 
0.4 and with humidification. BCPAP was then gradually extended to 24 h/day. 
Patient acceptance, complications and outcome were recorded. Results: 58 
patients received a TT to facilitate weaning. They had a median stay of 52 
days in the intensive care unit during which they had an endotracheal tube 
for 22 days and a TT for 28 days. 50 of these patients (86%) received BCPAP 
for a median of 16 days. The lightweight BCPAP system was well tolerated 
without tube obstructions or accidental decannulations and may have 
contributed to patient mobility. No patient remained on ventilatory support 
after hospital discharge. In-hospital and 1-year survival were 86 and 71%, 
respectively. Conclusions: BCPAP is a feasible and safe method for weaning 
tracheostomy patients. Copyright © 2007 S. Karger AG.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal tube; positive end expiratory pressure; tracheostomy; tracheotomy tube; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; artificial ventilation; controlled study; female; follow up; human; intensive care unit; major clinical study; male; mediastinitis (therapy); patient attitude; patient mobility; polyneuropathy (surgery, therapy); pressure support ventilation; priority journal; respiratory distress syndrome (therapy); spinal cord transsection (therapy); survival rate; treatment outcome; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008239415
MEDLINE PMID
  17652948 (http://www.ncbi.nlm.nih.gov/pubmed/17652948)
PUI
  L351685434
DOI
  10.1159/000106551
FULL TEXT LINK
  http://dx.doi.org/10.1159/000106551
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00257931&id=doi:10.1159%2F000106551&atitle=Boussignac+continuous+positive+airway+pressure+for+weaning+with+tracheostomy+tubes&stitle=Respiration&title=Respiration&volume=75&issue=4&spage=427&epage=431&aulast=Dieperink&aufirst=Willem&auinit=W.&aufull=Dieperink+W.&coden=RESPB&isbn=&pages=427-431&date=2008&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 818
TITLE
  Spinal cord compression by an old untreated asymptomatic cervical spine 
injury - A rare case of misdiagnosed identity
AUTHOR NAMES
  Mehta A.; Gupta S.; Angral R.; Lachala S.
AUTHOR ADDRESSES
  (Mehta A., amehta2k@gmail.com; Gupta S.; Angral R.; Lachala S.) Deptt. of 
Anaesthesiology and Intensive Care, GMC, Jammu-180001, India.
CORRESPONDENCE ADDRESS
  A. Mehta, Deptt. of Anaesthesiology and Intensive Care, GMC, Jammu-180001, 
India. Email: amehta2k@gmail.com
FULL RECORD ENTRY DATE
  2008-08-13
SOURCE
  Journal of Anaesthesiology Clinical Pharmacology (2008) 24:2 (237-238). Date 
of Publication: April 2008
VOLUME
  24
ISSUE
  2
FIRST PAGE
  237
LAST PAGE
  238
DATE OF PUBLICATION
  April 2008
ISSN
  0970-9185
BOOK PUBLISHER
  Journal of Anaesthesiology Clinical Pharmacology, Dayanand Medical College 
and Hospital, Ludhiana, India.
EMTREE DRUG INDEX TERMS
  antibiotic agent; immunoglobulin (drug therapy); multivitamin; potassium; thiopental (drug combination, pharmacology); vecuronium (drug combination, pharmacology); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (diagnosis, surgery, therapy); diagnostic error; spinal cord compression (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  analgesia; anamnesis; anesthesiological procedure; antibiotic therapy; article; artificial ventilation; bone transplantation; case report; cervical spine dislocation (diagnosis); clinical examination; computer assisted tomography; endotracheal intubation; gas; Guillain Barre syndrome; human; intensive care unit; limb weakness; male; nasogastric tube; neuroimaging; nuclear magnetic resonance imaging; nutrition; odontoid process fracture (diagnosis); physiotherapy; potassium intake; respiratory failure (drug therapy, therapy); school child; seizure; tracheostomy; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
  potassium (7440-09-7)
  thiopental (71-73-8, 76-75-5)
  vecuronium (50700-72-6)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Anesthesiology (24)
  Clinical and Experimental Pharmacology (30)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2008295250
PUI
  L351845578
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09709185&id=doi:&atitle=Spinal+cord+compression+by+an+old+untreated+asymptomatic+cervical+spine+injury+-+A+rare+case+of+misdiagnosed+identity&stitle=J.+Anaesthesiol.+Clin.+Pharmacol.&title=Journal+of+Anaesthesiology+Clinical+Pharmacology&volume=24&issue=2&spage=237&epage=238&aulast=Mehta&aufirst=Anjali&auinit=A.&aufull=Mehta+A.&coden=JAPHF&isbn=&pages=237-238&date=2008&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 819
TITLE
  An autopsy case of amyotrophic lateral sclerosis with ampulla cardiomyopathy
AUTHOR NAMES
  Matsuyama Y.; Sasagasako N.; Koike A.; Matsuura M.; Koga T.; Kawajiri M.; Ohyagi Y.; Iwaki T.; Kira J.-I.
AUTHOR ADDRESSES
  (Matsuyama Y.; Sasagasako N.) Department of Neurology, Fukuoka Higashi 
Medical Center, .
(Koike A.) Department of Cardiology, Fukuoka Higashi Medical Center, .
(Matsuura M.; Koga T.) Department of Pathology, Graduate School of Medical 
Sciences, Kyushu University, .
(Kawajiri M.; Ohyagi Y.; Iwaki T.; Kira J.-I.) Department of Neurology, 
Graduate School of Medical Sciences, Kyushu University, .
(Matsuyama Y.) Department of Neurology, Hamanomachi Hospital, .
CORRESPONDENCE ADDRESS
  Y. Matsuyama, Department of Neurology, Fukuoka Higashi Medical Center, 
Japan.
FULL RECORD ENTRY DATE
  2008-10-03
SOURCE
  Clinical Neurology (2008) 48:4 (249-254). Date of Publication: April 2008
VOLUME
  48
ISSUE
  4
FIRST PAGE
  249
LAST PAGE
  254
DATE OF PUBLICATION
  April 2008
ISSN
  0009-918X
BOOK PUBLISHER
  Societas Neurologica Japonica, 31-21 Yushima 2-chome, Bunkyo-ku, Tokyo, 
Japan.
ABSTRACT
  We herein report an autopsy case of a 63-year-old man with amyotrophic 
lateral sclerosis (ALS) who developed "ampulla cardiomyopathy." At the age 
of 56, he noticed a progressive weakness in his right upper extremity. One 
year later, a progressive weakness of the left upper extremity began. 
Dropped head and progressive weakness of the lower extremities emerged at 
the ages of 61 and 62, respectively. Intravenous immunoglobulin and 
plasma-exchange therapies did not improve his weakness. At the age of 63, 
one month before his death, he was hospitalized due to aspiration pneumonia. 
A tracheostomy was performed to secure his airway. Four days after the 
operation, an ST elevation of his electrocardiogram was incidentally found 
on the ECG monitor. An echocardiogram revealed diffuse hypokinesia of the 
wall of the left ventricle except in the basal portion, which is the typical 
finding of "ampulla cardiomyopathy." Wall motion of the left ventricle 
improved and his circulatory condition was stabilized after treatment, but 
his condition thereafter worsened again and he died 3 weeks later. An 
autopsy examination revealed diffuse fibrosis and degeneration of the 
cardiomyofibers. Neuropathological examination revealed neuronal cell loss, 
Bunina bodies and skein-like inclusions in the hippoglossal nuclei. In the 
thoracic spinal cord, degenarated anterior horn cells were seen and 
macrophage permeation in the corticospinal tract were shown by CD68 
immunostaining. Therefore, the final neuropathological diagnosis was ALS. 
This report is the first autopsy case of ALS complicated with "ampulla 
cardiomyopathy.".
EMTREE DRUG INDEX TERMS
  CD68 antigen (endogenous compound); immunoglobulin (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (drug therapy); cardiomyopathy; 
EMTREE MEDICAL INDEX TERMS
  adult; anterior horn cell; arm weakness; article; aspiration pneumonia; autopsy; cardiac muscle cell; case report; echocardiography; electrocardiogram; heart left ventricle wall; heart muscle fibrosis; histopathology; human; human tissue; hypoglossal nucleus; hypokinesia; immunohistochemistry; macrophage; male; plasmapheresis; pyramidal tract; ST segment elevation; thoracic spinal cord; tracheostomy; 
CAS REGISTRY NUMBERS
  immunoglobulin (9007-83-4)
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2008422026
MEDLINE PMID
  18453156 (http://www.ncbi.nlm.nih.gov/pubmed/18453156)
PUI
  L352285562
DOI
  10.5692/clinicalneurol.48.249
FULL TEXT LINK
  http://dx.doi.org/10.5692/clinicalneurol.48.249
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0009918X&id=doi:10.5692%2Fclinicalneurol.48.249&atitle=An+autopsy+case+of+amyotrophic+lateral+sclerosis+with+ampulla+cardiomyopathy&stitle=Clin.+Neurol.&title=Clinical+Neurology&volume=48&issue=4&spage=249&epage=254&aulast=Matsuyama&aufirst=Yumi&auinit=Y.&aufull=Matsuyama+Y.&coden=RISHD&isbn=&pages=249-254&date=2008&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 820
TITLE
  Long-Term Ventilation for High-Level Tetraplegia: A Report of 2 Cases of 
Noninvasive Positive-Pressure Ventilation
AUTHOR NAMES
  Toki A.; Tamura R.; Sumida M.
AUTHOR ADDRESSES
  (Toki A., atoki@msic.med.osaka-cu.ac.jp; Sumida M.) Department of 
Rehabilitation, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
(Tamura R.) Maizuru National Defense Medical Hospital, Maizuru, Kyoto, 
Japan.
CORRESPONDENCE ADDRESS
  A. Toki, Department of Rehabilitation, Kansai Rosai Hospital, Amagasaki, 
Hyogo, Japan. Email: atoki@msic.med.osaka-cu.ac.jp
FULL RECORD ENTRY DATE
  2008-04-14
SOURCE
  Archives of Physical Medicine and Rehabilitation (2008) 89:4 (779-783). Date 
of Publication: April 2008
VOLUME
  89
ISSUE
  4
FIRST PAGE
  779
LAST PAGE
  783
DATE OF PUBLICATION
  April 2008
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Toki A, Tamura R, Sumida M. Long-term ventilation for high-level 
tetraplegia: a report of 2 cases of noninvasive positive-pressure 
ventilation. Ventilator-dependent patients with tetraplegia rarely use 
noninvasive positive-pressure ventilation (NPPV) for long-term ventilation. 
We report 2 patients with high-level traumatic tetraplegia who were able to 
return home after being changed from traditional ventilation to NPPV. When 
they were referred to our hospital from acute care hospitals 2 to 6 months 
after injury, both were on tracheostomy ventilation with a cuff inflated 24 
hours a day, and tidal volume (Vt) settings were low. In case 1, a man with 
complete C1 tetraplegia was admitted to our hospital 6 months after injury. 
We changed ventilator settings to high Vt and introduced NPPV. He was 
discharged home with NPPV with a volume-setting ventilator. Case 2 involved 
a man in his late twenties with complete C1 tetraplegia who was discharged 
home with NPPV. After discharge, he trained in glossopharyngeal breathing by 
himself, enabling him to breathe up to 1900mL of maximum insufflation 
capacity. Both have lived nearly 1 year without pulmonary complications in 
the community. They use visiting nurses 3 times a week and services of 
visiting caregivers. Further study is needed to determine the usefulness of 
NPPV for long-term ventilatory management. © 2008 American Congress of 
Rehabilitation Medicine and the American Academy of Physical Medicine and 
Rehabilitation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  positive end expiratory pressure; quadriplegia (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; case report; emergency care; human; long term care; male; outcome assessment; spinal cord injury (therapy); tracheostomy; treatment outcome; treatment response; ventilator; vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008137290
MEDLINE PMID
  18374013 (http://www.ncbi.nlm.nih.gov/pubmed/18374013)
PUI
  L351406320
DOI
  10.1016/j.apmr.2007.09.043
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2007.09.043
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2Fj.apmr.2007.09.043&atitle=Long-Term+Ventilation+for+High-Level+Tetraplegia%3A+A+Report+of+2+Cases+of+Noninvasive+Positive-Pressure+Ventilation&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=89&issue=4&spage=779&epage=783&aulast=Toki&aufirst=Akiko&auinit=A.&aufull=Toki+A.&coden=APMHA&isbn=&pages=779-783&date=2008&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 821
TITLE
  Advanced Trauma Life Support (ATLS) and facial trauma: can one size fit 
all?. Part 2: ATLS, maxillofacial injuries and airway management dilemmas
AUTHOR NAMES
  Perry M.; Morris C.
AUTHOR ADDRESSES
  (Perry M., mikepmaxfax@yahoo.com) Regional and Maxillofacial Trauma Units, 
Belfast, United Kingdom.
(Morris C.) Derbyshire Royal Infirmary, Derby, United Kingdom.
CORRESPONDENCE ADDRESS
  M. Perry, Regional and Maxillofacial Trauma Units, Belfast, United Kingdom. 
Email: mikepmaxfax@yahoo.com
FULL RECORD ENTRY DATE
  2008-05-02
SOURCE
  International Journal of Oral and Maxillofacial Surgery (2008) 37:4 
(309-320). Date of Publication: April 2008
VOLUME
  37
ISSUE
  4
FIRST PAGE
  309
LAST PAGE
  320
DATE OF PUBLICATION
  April 2008
ISSN
  0901-5027
BOOK PUBLISHER
  Churchill Livingstone, 1-3 Baxter's Place, Leith Walk, Edinburgh, United 
Kingdom.
ABSTRACT
  Maxillofacial trauma poses an obvious threat to the patient's airway, which 
may not be immediately evident. In the multiply injured patient, the 
co-existence of actual or potential injuries elsewhere may complicate airway 
management, notably in the presence of full spinal immobilization. Following 
high-velocity trauma, injuries to the cervical spine must be assumed to be 
present. They also need to be ruled out in an appropriate and timely manner, 
as patients may wish to sit up. Assessment and management of the airway in 
maxillofacial trauma can be difficult, requiring a senior anaesthetist or 
other individual appropriately trained in emergency airway care. A number of 
management options may exist to protect the airway, each with advantages and 
drawbacks. Agitation and vomiting can occur unexpectedly and need to be 
managed safely with due consideration to the spine. Oral and maxillofacial 
surgeons need to be aware of these dilemmas and their early warning signs, 
and be skilled in emergency surgical airway procedures, especially if 
involved as part of the trauma team. Prolonged immobilization is associated 
with significant morbidity and mortality. A number of protocols currently 
exist for 'clearing' the spine. Imaging now plays a greater role, especially 
in the obtunded, unconscious or intubated patient, and this is discussed. © 
2007 International Association of Oral and Maxillofacial Surgeons.
EMTREE DRUG INDEX TERMS
  glucocorticoid (drug therapy); methylprednisolone (drug dose, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  face injury; long term care; maxillofacial injury; 
EMTREE MEDICAL INDEX TERMS
  agitation; airway; airway obstruction (surgery, therapy); alcohol intoxication; analgesia; bleeding; brain injury; cervical spine; cervical spine injury; clinical feature; clinical practice; disease association; drug megadose; edema (drug therapy); endotracheal intubation; health hazard; human; hypovolemia; immobilization; intracranial pressure; intubation; lung clearance; mandible fracture; morbidity; mortality; oxygenation; patient assessment; patient care; patient monitoring; pulse oximetry; review; spinal cord injury; tracheostomy; tracheotomy; vestibular disorder; vomiting; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008152580
MEDLINE PMID
  18207702 (http://www.ncbi.nlm.nih.gov/pubmed/18207702)
PUI
  L351446099
DOI
  10.1016/j.ijom.2007.11.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijom.2007.11.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09015027&id=doi:10.1016%2Fj.ijom.2007.11.002&atitle=Advanced+Trauma+Life+Support+%28ATLS%29+and+facial+trauma%3A+can+one+size+fit+all%3F.+Part+2%3A+ATLS%2C+maxillofacial+injuries+and+airway+management+dilemmas&stitle=Int.+J.+Oral+Maxillofac.+Surg.&title=International+Journal+of+Oral+and+Maxillofacial+Surgery&volume=37&issue=4&spage=309&epage=320&aulast=Perry&aufirst=M.&auinit=M.&aufull=Perry+M.&coden=IJOSE&isbn=&pages=309-320&date=2008&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 822
TITLE
  An assessment of early tracheostomy after anterior cervical stabilization in 
patients with acute cervical spine trauma
AUTHOR NAMES
  Berney S.; Opdam H.; Bellomo R.; Liew S.; Skinner E.; Egi M.; Denehy L.
AUTHOR ADDRESSES
  (Berney S., sue.berney@austin.org.au; Skinner E.) Department of 
Physiotherapy, Austin Hospital, Melbourne, VIC, Australia.
(Opdam H.; Bellomo R.; Egi M.) Department of Intensive Care, Austin 
Hospital, Melbourne, VIC, Australia.
(Liew S.) Department of Orthopaedics, Austin Hospital, Melbourne, VIC, 
Australia.
(Denehy L.) School of Physiotherapy, University of Melbourne, Melbourne, 
VIC, Australia.
(Berney S., sue.berney@austin.org.au) Department of Physiotherapy, Austin 
Hospital, Studley R, Heidelberg, VIC 3084, Australia.
CORRESPONDENCE ADDRESS
  S. Berney, Department of Physiotherapy, Austin Hospital, Studley R, 
Heidelberg, VIC 3084, Australia. Email: sue.berney@austin.org.au
FULL RECORD ENTRY DATE
  2008-04-01
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2008) 64:3 
(749-753). Date of Publication: March 2008
VOLUME
  64
ISSUE
  3
FIRST PAGE
  749
LAST PAGE
  753
DATE OF PUBLICATION
  March 2008
ISSN
  0022-5282
  1529-8809 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  BACKGROUND: The optimal timing of tracheostomy after anterior cervical spine 
surgery remains controversial because of the potential for deep infection. 
The aims of this study were to compare the infection rates in patients 
requiring tracheostomy who underwent anterior versus posterior cervical 
spine surgery, and to report the timing of tracheostomy tube placement in 
such patients. METHOD: All patients admitted to a referral Intensive Care 
Unit for spinal trauma from January 1998 until May 2005, who underwent 
surgical stabilization with instrumentation and also received a 
tracheostomy, were retrospectively evaluated for demographic data, severity 
of neurologic injury, and complications including infection to a surgical 
site and timing and type of tracheostomy procedure. RESULTS: We identified 
71 patients, all who had a diagnosis of acute cervical spine injury. 
Thirty-two (45%) underwent anterior stabilization, 15 (21%) had posterior 
stabilizations, and 24 (34%) required both anterior and posterior 
approaches. The mean time from stabilization to tracheostomy for an anterior 
approach was 3.8 ± 2.6 days. There was no significant difference in the 
timing of tracheostomy for different surgical approaches. Seventeen patients 
(25%) had a positive culture of their cervical and or tracheostomy incision 
site. Only one patient, however, had infection with the same organism at 
both the tracheostomy site and the anterior stabilization site. Suspected 
infection was managed with antibiotics and no further surgical intervention 
was required. CONCLUSIONS: Early tracheostomy after spinal stabilization is 
associated with a low risk of infection even after the anterior approach. © 
2008 Lippincott Williams & Wilkins, Inc.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; controlled study; female; human; infection rate (complication, drug therapy); intermethod comparison; major clinical study; male; postoperative care; postoperative complication (complication); priority journal; spine stabilization; tracheostomy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008124007
MEDLINE PMID
  18332819 (http://www.ncbi.nlm.nih.gov/pubmed/18332819)
PUI
  L351366904
DOI
  10.1097/.TA.0b013e31802c8234
FULL TEXT LINK
  http://dx.doi.org/10.1097/.TA.0b013e31802c8234
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:10.1097%2F.TA.0b013e31802c8234&atitle=An+assessment+of+early+tracheostomy+after+anterior+cervical+stabilization+in+patients+with+acute+cervical+spine+trauma&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=64&issue=3&spage=749&epage=753&aulast=Berney&aufirst=Susan&auinit=S.&aufull=Berney+S.&coden=JOTRF&isbn=&pages=749-753&date=2008&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 823
TITLE
  The use of mechanical ventilation is appropriate in children with 
genetically proven spinal muscular atrophy type 1: the motion for
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R., Bachjr@umdnj.edu) Department of Physical Medicine and 
Rehabilitation, UMDNJ-New Jersey Medical School, Newark, NJ, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine and Rehabilitation, UMDNJ-New 
Jersey Medical School, Newark, NJ, United States. Email: Bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2008-02-28
SOURCE
  Paediatric Respiratory Reviews (2008) 9:1 (45-50). Date of Publication: 
March 2008
VOLUME
  9
ISSUE
  1
FIRST PAGE
  45
LAST PAGE
  50
DATE OF PUBLICATION
  March 2008
ISSN
  1526-0542
  1526-0550 (electronic)
BOOK PUBLISHER
  W.B. Saunders Ltd, 32 Jamestown Road, London, United Kingdom.
ABSTRACT
  The purpose of this paper is to report prolongation of survival for 
Werdnig-Hoffman's disease (spinal muscular atrophy type 1, SMA 1) by use of 
non-invasive respiratory muscle aids compared with tracheostomy, and to 
present reasons for offering this as an option to the parents of these 
children. Ninety per cent of typical untreated SMA 1 patients die before 12 
months of age and 100% by 24 months of age. Tracheostomy can prolong 
survival to over 20 years of age in some cases, but patients with tubes do 
not develop the ability to speak and lose all ability to breathe from the 
point of the tracheotomy. In contrast, the majority of non-invasively 
managed SMA 1 patients develop the ability to communicate verbally and 
maintain some autonomous breathing ability. Clinicians' treatment paradigms 
associate ventilatory support with invasive tubes and do not recognise 
aiding respiratory muscles. Clinicians also significantly underestimate the 
care providers' view of the patient's quality of life. As a result, they 
rarely offer non-invasive means to prolong life. In conclusion, both 
non-invasive aids and tracheostomy can prolong survival for SMA 1 patients, 
and it should be left up to the family to decide which, if either, they 
would like to use. © 2007 Elsevier Ltd. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; Werdnig Hoffmann disease (diagnosis, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; breathing disorder (complication); breathing muscle; death; endotracheal tube; health care delivery; human; non invasive procedure; priority journal; quality of life; review; speech disorder (complication); survival time; tracheostomy; treatment outcome; verbal communication; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008074764
MEDLINE PMID
  18280979 (http://www.ncbi.nlm.nih.gov/pubmed/18280979)
PUI
  L50054575
DOI
  10.1016/j.prrv.2007.11.003
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.prrv.2007.11.003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15260542&id=doi:10.1016%2Fj.prrv.2007.11.003&atitle=The+use+of+mechanical+ventilation+is+appropriate+in+children+with+genetically+proven+spinal+muscular+atrophy+type+1%3A+the+motion+for&stitle=Paediatr.+Respir.+Rev.&title=Paediatric+Respiratory+Reviews&volume=9&issue=1&spage=45&epage=50&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=PRRAE&isbn=&pages=45-50&date=2008&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 824
TITLE
  Intermittent atlantoaxial subluxation caused by a prolapsing neurofibroma: 
Case report
AUTHOR NAMES
  Kelleher M.O.; Quarishi N.A.; Tan G.; Guha A.; Massicotte E.M.
AUTHOR ADDRESSES
  (Massicotte E.M., Eric.Massicotte@uhn.on.ca) Krembil Neuroscience Centre, 
Toronto Western Hospital, West Wing, 399 Bathurst Street, Toronto, ON, 
Canada.
(Kelleher M.O.; Quarishi N.A.; Tan G.; Guha A.)
CORRESPONDENCE ADDRESS
  E. M. Massicotte, Krembil Neuroscience Centre, Toronto Western Hospital, 
West Wing, 399 Bathurst Street, Toronto, ON, Canada. Email: 
Eric.Massicotte@uhn.on.ca
FULL RECORD ENTRY DATE
  2008-04-08
SOURCE
  Journal of Neurosurgery: Spine (2008) 8:3 (288-291). Date of Publication: 
March 2008
VOLUME
  8
ISSUE
  3
FIRST PAGE
  288
LAST PAGE
  291
DATE OF PUBLICATION
  March 2008
ISSN
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  In this report, the authors describe a unique case of intermittent high 
cervical cord compression caused by a prolapsing neurofibroma at the C1-2 
level. This 21-year-old man with known neurofibromatosis Type 1 presented 
with a mass between the anterior arch of the atlas and the odontoid peg, 
causing atlantoaxial dissociation and cord compression. The cervicomedullary 
compression appeared to be caused in part by the neurofibroma but also by 
the abnormal alignment and thickening of the ligaments between the clivus 
and C-2. Preoperative imaging repeated on the morning of surgery revealed 
that the atlantoaxial dissociation had reduced with relief of cord 
compression and the lesion prolapsed inferiorly. The authors discuss this 
unusual lesion and describe the associated operative findings and surgical 
management.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantoaxial subluxation (diagnosis); neurofibromatosis (diagnosis, etiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; computer assisted tomography; human; male; nuclear magnetic resonance imaging; spinal cord compression; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008139525
MEDLINE PMID
  18312082 (http://www.ncbi.nlm.nih.gov/pubmed/18312082)
PUI
  L351413958
DOI
  10.3171/SPI/2008/8/3/288
FULL TEXT LINK
  http://dx.doi.org/10.3171/SPI/2008/8/3/288
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475654&id=doi:10.3171%2FSPI%2F2008%2F8%2F3%2F288&atitle=Intermittent+atlantoaxial+subluxation+caused+by+a+prolapsing+neurofibroma%3A+Case+report&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=8&issue=3&spage=288&epage=291&aulast=Massicotte&aufirst=Eric+M.&auinit=E.M.&aufull=Massicotte+E.M.&coden=&isbn=&pages=288-291&date=2008&auinit1=E&auinitm=M
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 825
TITLE
  Editorial Overview: Is the use of invasive ventilation appropriate in 
children with genetically proven spinal muscular atrophy type 1?
AUTHOR NAMES
  Tobin B.
AUTHOR ADDRESSES
  (Tobin B.) Plunkett Centre for Ethics, St Vincent's Hospital, Sydney, 
Australia.
CORRESPONDENCE ADDRESS
  B. Tobin, Plunkett Centre for Ethics, St Vincent's Hospital, Sydney, 
Australia.
FULL RECORD ENTRY DATE
  2008-02-28
SOURCE
  Paediatric Respiratory Reviews (2008) 9:1 (55-56). Date of Publication: 
March 2008
VOLUME
  9
ISSUE
  1
FIRST PAGE
  55
LAST PAGE
  56
DATE OF PUBLICATION
  March 2008
ISSN
  1526-0542
  1526-0550 (electronic)
BOOK PUBLISHER
  W.B. Saunders Ltd, 32 Jamestown Road, London, United Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; Werdnig Hoffmann disease (diagnosis, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  child care; editorial; endotracheal intubation; endotracheal tube; face mask; health care availability; health practitioner; hospitalization; human; intensive care; invasive procedure; medical decision making; non invasive procedure; physiotherapy; priority journal; resource allocation; responsibility; risk benefit analysis; surgical risk; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2008074761
PUI
  L50055874
DOI
  10.1016/j.prrv.2007.10.004
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.prrv.2007.10.004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15260542&id=doi:10.1016%2Fj.prrv.2007.10.004&atitle=Editorial+Overview%3A+Is+the+use+of+invasive+ventilation+appropriate+in+children+with+genetically+proven+spinal+muscular+atrophy+type+1%3F&stitle=Paediatr.+Respir.+Rev.&title=Paediatric+Respiratory+Reviews&volume=9&issue=1&spage=55&epage=56&aulast=Tobin&aufirst=Bernadette&auinit=B.&aufull=Tobin+B.&coden=PRRAE&isbn=&pages=55-56&date=2008&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 826
TITLE
  Percutaneous tracheostomy for the management of the patient with a difficult 
airway
AUTHOR NAMES
  Suzuki H.; Aoyagi M.
AUTHOR ADDRESSES
  (Suzuki H.; Aoyagi M.) Anesthesia and Critical Care Service, Chiba Aoba 
Municipal Hospital, Chiba 260-0852.
CORRESPONDENCE ADDRESS
  H. Suzuki, Anesthesia and Critical Care Service, Chiba Aoba Municipal 
Hospital, Chiba 260-0852.
FULL RECORD ENTRY DATE
  2008-03-04
SOURCE
  Japanese Journal of Anesthesiology (2008) 57:2 (147-151). Date of 
Publication: February 2008
VOLUME
  57
ISSUE
  2
FIRST PAGE
  147
LAST PAGE
  151
DATE OF PUBLICATION
  February 2008
ISSN
  0021-4892
BOOK PUBLISHER
  Kokuseido Publishing Co. Ltd, 23-5-202 Hongo, 3-chome, Bunkyo-ku, Tokyo, 
Japan.
ABSTRACT
  Background : In recent years, percutaneous tracheostomy has been performed 
in patients with adverse conditions such as short neck, obesity, 
coagulopathy or in emergency. Methods : We performed percutaneous 
tracheostomy with Griggs' or Ciaglia's technique in five patients with 
difficult airways due to laryngeal tumors, a laryngeal edema, a neck cancer 
or a cervical injury. Results : Well-trained anesthesiologists performed all 
procedures. In four patients, percutaneous tracheostomy was completed 
rapidly without any complications. The rest of patients underwent 
orotracheal intubation successfully with a percutaneous tracheostomy set 
prepared for an emergency situation. We call this setting "Stand-by PCT". 
Conclusions : We believe that percutaneous tracheostomy in well-trained 
hands can be used safely for the management of the patient with a difficult 
airway.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); larynx edema (surgery); larynx tumor (surgery); neck cancer (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; anesthesist; article; blood clotting disorder (complication); endotracheal intubation; health service; human; intensive care; neck malformation (complication); obesity (complication); surgical technique; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Cancer (16)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2008087284
MEDLINE PMID
  18277559 (http://www.ncbi.nlm.nih.gov/pubmed/18277559)
PUI
  L351263063
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00214892&id=doi:&atitle=Percutaneous+tracheostomy+for+the+management+of+the+patient+with+a+difficult+airway&stitle=Jpn.+J.+Anesthesiol.&title=Japanese+Journal+of+Anesthesiology&volume=57&issue=2&spage=147&epage=151&aulast=Suzuki&aufirst=Hiroto&auinit=H.&aufull=Suzuki+H.&coden=MASUA&isbn=&pages=147-151&date=2008&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 827
TITLE
  Medical rehabilitation of the patients with spinal cord injury caused by 
aortic aneurysm and its operation
AUTHOR NAMES
  Ohsawa S.; Tamaki M.; Hirabayashi S.
AUTHOR ADDRESSES
  (Ohsawa S., oosawa-suguru@sumitomo-hp.or.jp; Tamaki M.; Hirabayashi S.) 
Department of Rehabilitation Medicine, Osaka Rosai Hospital, Osaka, Japan.
(Ohsawa S., oosawa-suguru@sumitomo-hp.or.jp) Department of Orthopedic 
Surgery, Sumitomo Hospital, 5-3-20, Nakanoshima, Kita-Ku, Osaka 530-0005, 
Japan.
CORRESPONDENCE ADDRESS
  S. Ohsawa, Department of Orthopedic Surgery, Sumitomo Hospital, 5-3-20, 
Nakanoshima, Kita-Ku, Osaka 530-0005, Japan. Email: 
oosawa-suguru@sumitomo-hp.or.jp
FULL RECORD ENTRY DATE
  2008-02-20
SOURCE
  Spinal Cord (2008) 46:2 (150-153). Date of Publication: February 2008
VOLUME
  46
ISSUE
  2
FIRST PAGE
  150
LAST PAGE
  153
DATE OF PUBLICATION
  February 2008
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Objectives: To determine the natural course of spinal cord injury (SCI) 
after aortic aneurysm surgery. Setting: Acute care and semi-acute wards in 
Osaka Rosai Hospital, Japan. Methods: From 1998 to 2003, 12 patients with 
thoracic SCI (eight men and four women; mean age: 69 years) were enrolled 
and evaluated by the American Spinal Injury Association (ASIA) impairment 
scale and Functional Independence Measure (FIM), and the results were 
analyzed. Results: The level of SCI was distributed from T5 to L1. The ASIA 
impairment scale was A in four patients, B in four, C in three and D in one. 
Finally, six patients were discharged to home, and two patients died during 
hospitalization. Excluding the value of the deceased patients, the mean 
motor FIM was initially 32±15.6 (13-59) points and became 61±21.4 (29-88) 
points at discharge. Referencing the databases of SCI in Japan and USA 
revealed that the complication rates of pneumonia and aspiration were higher 
in our cases. The motor FIM before rehabilitation and at discharge were 
relatively lower than in the databases, but the gain and the rate of gain 
were similar to the Japanese database. Conclusion: SCI associated with 
aortic aneurysm surgery was noticed especially in the elderly patients using 
airways (for example, tracheostomy). The higher age and recurrent nerve 
palsy were associated with deconditioning state to develop aspiration 
pneumonia. This state impaired the general condition, and such vicious cycle 
led to poor prognosis and functional outcome. © 2008 International Spinal 
Cord Society All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dissecting aneurysm (surgery); spinal cord injury (complication, rehabilitation); thoracic aorta aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; age distribution; aged; aneurysm surgery; article; aspiration pneumonia (complication); clinical article; controlled study; female; Functional Independence Measure; hospital discharge; hospitalization; human; Japan; male; pneumonia (complication); priority journal; rating scale; sex ratio; thoracic spinal cord; United States; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008071034
MEDLINE PMID
  17471292 (http://www.ncbi.nlm.nih.gov/pubmed/17471292)
PUI
  L351220574
DOI
  10.1038/sj.sc.3102075
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3102075
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3102075&atitle=Medical+rehabilitation+of+the+patients+with+spinal+cord+injury+caused+by+aortic+aneurysm+and+its+operation&stitle=Spinal+Cord&title=Spinal+Cord&volume=46&issue=2&spage=150&epage=153&aulast=Ohsawa&aufirst=S.&auinit=S.&aufull=Ohsawa+S.&coden=SPCOF&isbn=&pages=150-153&date=2008&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 828
TITLE
  Upper aerodigestive tract sequelae in severe enterovirus 71 infection: 
Predictors and outcome
AUTHOR NAMES
  Tsou Y.-A.; Cheng Y.-K.; Chung H.-K.; Yeh Y.-C.; Lin C.-D.; Tsai M.-H.; Chang J.-S.
AUTHOR ADDRESSES
  (Tsou Y.-A.; Cheng Y.-K.; Chung H.-K.; Lin C.-D., tsou121212@yahoo.com.tw; 
Tsai M.-H.) Department of Otolaryngology, China Medical University Hospital, 
Taichung, Taiwan.
(Yeh Y.-C.) Biostatistics Center, China Medical University, Taichung, 
Taiwan.
(Chang J.-S.) Department of Pediatrics, China Medical University, Taichung, 
Taiwan.
CORRESPONDENCE ADDRESS
  C.-D. Lin, Department of Otolaryngology, China Medical University Hospital, 
Taichung, Taiwan. Email: tsou121212@yahoo.com.tw
FULL RECORD ENTRY DATE
  2007-12-31
SOURCE
  International Journal of Pediatric Otorhinolaryngology (2008) 72:1 (41-47). 
Date of Publication: January 2008
VOLUME
  72
ISSUE
  1
FIRST PAGE
  41
LAST PAGE
  47
DATE OF PUBLICATION
  January 2008
ISSN
  0165-5876
BOOK PUBLISHER
  Elsevier Ireland Ltd, P.O. Box 85, Limerick, Ireland.
ABSTRACT
  Objective: Enterovirus 71 (EV71) infection sequelae can be severe and 
life-threatening, and long-term follow-up outcomes remain unknown. 
Therefore, we conducted a retrospective follow-up study to review airway and 
neurological sequelae development in patients with severe EV71 infection. We 
also studied the incidence and risk factors for tracheotomy and gastrostomy 
requirement. Patients and methods: We investigated 202 EV71-infected 
children according to their disease stage. Seventy-two of them were 
diagnosed to have EV71 encephalitis, which was characterized by myoclonus, 
ataxia, nystagmus, oculomotor palsy and bulbar palsy or combinations of 
these conditions. All the 72 patients required endotracheal intubation due 
to respiratory failure or ventilator dependence; among these, 14 underwent 
tracheostomy and 10 underwent gastrostomy. All patients were followed-up for 
at least 3 years after discharge. Predictors of tracheostomy and gastrostomy 
requirement were age <2 years, body weight <10th percentile, pulmonary 
hemorrhage or edema, meningeal symptoms and magnetic resonance imaging (MRI) 
findings of upper spinal cord and brainstem. We determined outcome based on 
persistent tracheostomy or gastrostomy requirement and whether patients 
developed positive neurological sequelae. Results: Significant tracheostomy 
and gastrostomy predictors were age <2 years, pulmonary edema or hemorrhage, 
hypotension, hemiparesis and positive MRI findings. Statistical analysis 
revealed pulmonary edema and hypotension as index predictors of tracheostomy 
requirement and pulmonary edema as the significant risk factor for 
gastrostomy. Conclusions: Long-term neuropsychological impact was observed 
on children who present the signs of the pulmonary edema or hypotension in 
the early onset of the EV71 infection. EV71-infected patients who develop 
neurological pulmonary edema or hypotension should be hemodynamically 
stabilized and undergo early tracheostomy to prevent further complications. 
This may improve the decannulation success rate after the brainstem function 
recovers. © 2007 Elsevier Ireland Ltd. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  encephalitis (diagnosis, etiology); Enterovirus infection (diagnosis); neurologic disease; respiratory tract infection; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; ataxia; body weight; brain stem; bulbar paralysis; controlled study; disease severity; endotracheal intubation; Enterovirus A71; female; follow up; gastrostomy; human; hypotension; long term care; lung edema; lung hemorrhage; major clinical study; male; medical record review; morbidity; myoclonus; nuclear magnetic resonance imaging; nystagmus; ophthalmoplegia; pathogenesis; preschool child; priority journal; respiratory failure (therapy); spinal cord; surgical risk; surgical technique; tracheostomy; 
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Pediatrics and Pediatric Surgery (7)
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007586896
MEDLINE PMID
  18029029 (http://www.ncbi.nlm.nih.gov/pubmed/18029029)
PUI
  L350198651
DOI
  10.1016/j.ijporl.2007.09.008
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ijporl.2007.09.008
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01655876&id=doi:10.1016%2Fj.ijporl.2007.09.008&atitle=Upper+aerodigestive+tract+sequelae+in+severe+enterovirus+71+infection%3A+Predictors+and+outcome&stitle=Int.+J.+Pediatr.+Otorhinolaryngol.&title=International+Journal+of+Pediatric+Otorhinolaryngology&volume=72&issue=1&spage=41&epage=47&aulast=Tsou&aufirst=Yung-An&auinit=Y.-A.&aufull=Tsou+Y.-A.&coden=IPOTD&isbn=&pages=41-47&date=2008&auinit1=Y&auinitm=-A
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 829
TITLE
  Respiratory management during the first five days after spinal cord injury
AUTHOR NAMES
  Berlly M.; Shem K.
AUTHOR ADDRESSES
  (Berlly M., michael.berlly@hhs.sccgov.org; Shem K.) Santa Clara Valley 
Medical Center, 751 S. Bascom Avenue, San Jose, CA 95128, United States.
CORRESPONDENCE ADDRESS
  M. Berlly, Santa Clara Valley Medical Center, 751 S. Bascom Avenue, San 
Jose, CA 95128, United States. Email: michael.berlly@hhs.sccgov.org
FULL RECORD ENTRY DATE
  2009-01-19
SOURCE
  Journal of Spinal Cord Medicine (2007) 30:4 (309-318). Date of Publication: 
2007
VOLUME
  30
ISSUE
  4
FIRST PAGE
  309
LAST PAGE
  318
DATE OF PUBLICATION
  2007
ISSN
  1079-0268
BOOK PUBLISHER
  Maney Publishing, Suite 1C, Joseph's Well, Hanover Walk, Leeds, United 
Kingdom.
ABSTRACT
  Summary: Respiratory complications are the most common cause of morbidity 
and mortality in acute spinal cord'injury (SCI), with an incidence of 36% to 
83%. Eighty percent of deaths in patients hospitalized with cervical SCI are 
secondary to pulmonary dysfunction, with pneumonia the cause in 50% of the 
cases. The number of respiratory complications during the acute hospital 
stay contributes significantly to the length of hospital stay and cost. Four 
factors (use of mechanical ventilation, pneumonia, the need for surgery, and 
use of tracheostomy) explain nearly 60% of hospital costs and may be as 
important a predictor of hospital cost as level of injury. Atelectasis 
(36.4%), pneumonia (31.4%), and ventilatory failure (22.6%) are the most 
common complications during the first 5 days after injury. Ventilatory 
failure occurs on average 4.5 days after injury. Transfer to an SCI center 
specializing in acute management of tetraplegia has been shown to 
significantly reduce the number of respiratory complications. This review 
concentrates on the first 5 days after injury, focusing on complications, 
predictive factors, prevention, and management of those complications.
EMTREE DRUG INDEX TERMS
  acetylcysteine (drug therapy); aminophylline (drug therapy); bicarbonate (drug therapy, intranasal drug administration); cromoglycate disodium (drug therapy); methylprednisolone (drug dose, drug therapy, intravenous drug 
administration); oxandrolone (drug therapy); theophylline (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure (complication, disease management, drug therapy, 
surgery, therapy); spinal cord injury (disease management, drug therapy); 
EMTREE MEDICAL INDEX TERMS
  acute disease (disease management, drug therapy); artificial ventilation; assisted ventilation; atelectasis (complication, prevention, therapy); bronchospasm (complication); clinical assessment; cost benefit analysis; disease severity; drug megadose; endotracheal intubation; hematopneumothorax (complication, surgery); hospital cost; hospitalization; human; incidence; infection risk; intermittent positive pressure ventilation; length of stay; lung edema (complication); lung embolism (complication); morbidity; mortality; mucus secretion; pleura effusion (complication); pneumonia (complication); quadriplegia; review; risk reduction; thorax drainage; thorax injury; tidal volume; total parenteral nutrition; tracheostomy; vital capacity; 
DRUG TRADE NAMES
  mucomyst
CAS REGISTRY NUMBERS
  acetylcysteine (616-91-1)
  aminophylline (317-34-0)
  bicarbonate (144-55-8, 71-52-3)
  cromoglycate disodium (15826-37-6, 16110-51-3, 93356-79-7, 93356-84-4)
  methylprednisolone (6923-42-8, 83-43-2)
  oxandrolone (53-39-4)
  theophylline (58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Health Policy, Economics and Management (36)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008602076
MEDLINE PMID
  17853652 (http://www.ncbi.nlm.nih.gov/pubmed/17853652)
PUI
  L352842939
DOI
  10.1080/10790268.2007.11753946
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2007.11753946
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2007.11753946&atitle=Respiratory+management+during+the+first+five+days+after+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=30&issue=4&spage=309&epage=318&aulast=Berlly&aufirst=Michael&auinit=M.&aufull=Berlly+M.&coden=JSCMC&isbn=&pages=309-318&date=2007&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 830
TITLE
  Anterior spondylosis of the cervical spine causing dyspnea and sleep 
disturbance
ORIGINAL (NON-ENGLISH) TITLE
  Spondylophytäre Atem- und Schlafstörungen
AUTHOR NAMES
  Eysel-Gosepath K.; Fürderer S.; Delank K.-S.; Schröder U.; Eysel P.
AUTHOR ADDRESSES
  (Eysel-Gosepath K., pek.eysel@t-online.de; Fürderer S.; Delank K.-S.; Eysel 
P.) Klinik und Poliklinik für Orthopädie, Universitätsklinik Köln, .
(Schröder U.) Klinik und Poliklinik für HNO-Heilkunde, Universitätsklinik 
Köln, .
(Eysel-Gosepath K., pek.eysel@t-online.de)
(Eysel-Gosepath K., pek.eysel@t-online.de) Im Finkenhain 6, 50996 Köln.
CORRESPONDENCE ADDRESS
  K. Eysel-Gosepath, Im Finkenhain 6, 50996 Köln. Email: pek.eysel@t-online.de
FULL RECORD ENTRY DATE
  2008-05-23
SOURCE
  HNO (2007) 55:13 (997-1000). Date of Publication: December 2007
VOLUME
  55
ISSUE
  13
FIRST PAGE
  997
LAST PAGE
  1000
DATE OF PUBLICATION
  December 2007
ISSN
  0017-6192
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Background. Cervical osteochondrosis is a rare differential diagnosis 
leading to dysphagia, inspiratory stridor and obstructive sleep apnea 
syndrome (OSAS). Patients and methods. We report six cases of patients with 
episodes of neck pain (n=6), pain reflected to the arm (n=1), sleep apnea 
(n=5), inspiratory stridor (n=3) and/or unclear dysphagia (n=6), who 
presented between 2000 and 2003 at the Römerwallklinik Mainz and the 
university hospitals of Mainz and Cologne. None of these patients had 
symptoms of spinal or radicular compression. All underwent 
otorhinolaryngological and radiological examination followed by excision of 
anterior spondylophytes and intervertebral fusion. One patient required 
immediate tracheotomy due to perforation of the pharyngeal wall associated 
with severe supraglottic swelling. Results. All patients were free of 
inspiratory stridor postoperatively. Symptoms of dysphagia disappeared in 
four patients and were reduced in two. Three of five patients were free of 
apnea. OSAS had improved in two. Neck pain was eliminated in four cases and 
markedly improved in two cases. Conclusions. In case of symptoms of 
pharyngeal compression and OSAS, a vertebragenic cause should be considered. 
© 2007 Springer Medizin Verlag.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; neck pain (diagnosis, etiology, prevention); sleep disordered breathing (diagnosis, etiology, therapy); spondylosis (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; dyspnea (diagnosis, etiology, therapy); female; human; male; middle aged; treatment outcome; 
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
MEDLINE PMID
  17464494 (http://www.ncbi.nlm.nih.gov/pubmed/17464494)
PUI
  L351579832
DOI
  10.1007/s00106-007-1558-0
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00106-007-1558-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00176192&id=doi:10.1007%2Fs00106-007-1558-0&atitle=Anterior+spondylosis+of+the+cervical+spine+causing+dyspnea+and+sleep+disturbance&stitle=HNO&title=HNO&volume=55&issue=13&spage=997&epage=1000&aulast=Eysel-Gosepath&aufirst=K.&auinit=K.&aufull=Eysel-Gosepath+K.&coden=HBZHA&isbn=&pages=997-1000&date=2007&auinit1=K&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 831
TITLE
  Heterotopic ossification of the vocal cords after spinal cord injury
AUTHOR NAMES
  Zellig G.; Zwecker M.; Weingarden H.; Wolf M.
AUTHOR ADDRESSES
  (Zellig G.; Zwecker M., zwecker@gmail.com; Weingarden H.) Department of 
Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer, Ramat 
Gan, Israel.
(Zellig G.; Zwecker M., zwecker@gmail.com; Weingarden H.; Wolf M.) Sackler 
School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
(Wolf M.) Department of Otorhinolaryngology, Head and Neck Surgery, Chaim 
Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
(Zwecker M., zwecker@gmail.com) Department of Neurological Rehabilitation, 
Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel.
CORRESPONDENCE ADDRESS
  M. Zwecker, Department of Neurological Rehabilitation, Chaim Sheba Medical 
Center, Tel Hashomer, Ramat Gan, 52621, Israel. Email: zwecker@gmail.com
FULL RECORD ENTRY DATE
  2008-01-09
SOURCE
  Journal of Spinal Cord Medicine (2007) 30:5 (518-520). Date of Publication: 
2007
VOLUME
  30
ISSUE
  5
FIRST PAGE
  518
LAST PAGE
  520
DATE OF PUBLICATION
  2007
ISSN
  1079-0268
BOOK PUBLISHER
  American Paraplegia Society, 75-20 Astoria Boulevard, Jackson Heights, 
United States.
ABSTRACT
  Background/Objective: To report a rare complication of heterotopic 
ossification of the vocal cords after spinal cord and multiple organ 
injuries. Study Design: Case report. Setting: Acute rehabilitation in the 
Department of Neurologic Rehabilitation. Results: A 55-year-old patient 
sustained spinal cord injury and multitrauma after falling from a height. 
Approximately 3 months later, after weaning from mechanical ventilation, 
plugging of the cannula resulted in severe stridor indicating upper airway 
obstruction. A computed tomography scan showed bilateral vocal cord fixation 
in a para-median position, with hyperossification of the vocal processes of 
the arytenoids. Direct laryngoscopy revealed interarytenoid ossification, 
and sawing through the ossification resulted in remobilization of the vocal 
cords enabling decannulation. Conclusions: Heterotopic ossification of the 
vocal cords was found to be an early complication of acute spinal cord 
injury and multiple trauma. This rare complication should be considered in 
the differential diagnosis of patients showing signs of upper airway 
obstruction.
EMTREE DRUG INDEX TERMS
  etidronic acid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (drug therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; airway obstruction; article; case report; clinical feature; computer assisted tomography; human; laryngoscopy; larynx cartilage; ossification; vocal cord; 
CAS REGISTRY NUMBERS
  etidronic acid (2809-21-4, 3794-83-0, 58449-82-4, 7414-83-7)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007604639
MEDLINE PMID
  18092569 (http://www.ncbi.nlm.nih.gov/pubmed/18092569)
PUI
  L350247173
DOI
  10.1080/10790268.2007.11754586
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2007.11754586
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2007.11754586&atitle=Heterotopic+ossification+of+the+vocal+cords+after+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=30&issue=5&spage=518&epage=520&aulast=Zellig&aufirst=Gabi&auinit=G.&aufull=Zellig+G.&coden=JSCMC&isbn=&pages=518-520&date=2007&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 832
TITLE
  Severe upper airway obstruction due to retropharyngeal haematoma formation 
following cervical trauma
ORIGINAL (NON-ENGLISH) TITLE
  Subakute Verlegung der Atemwege infolge eines retropharyngealen Hämatoms 
nach Halstrauma
AUTHOR NAMES
  Haarmann S.; Budihardja A.S.; Mücke T.; Schwaegerl C.; Wolff K.D.
AUTHOR ADDRESSES
  (Haarmann S.; Budihardja A.S., a_budihardja@hotmail.com; Mücke T.; Wolff 
K.D.) Universitätsklinik für Mund-, Kiefer- und Plastische 
Gesichtschirurgie, Knappschaftskrankenhaus Bochum Langendreer, Ruhr 
Universität Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
(Schwaegerl C.) Klinik für Radiologie, Knappschaftskrankenhaus Bochum 
Langendreer, Ruhr Universität Bochum, In der Schornau 23-25, 44892 Bochum, 
Germany.
CORRESPONDENCE ADDRESS
  A.S. Budihardja, Universitätsklinik für Mund-, Kiefer- und Plastische 
Gesichtschirurgie, Knappschaftskrankenhaus Bochum Langendreer, Ruhr 
Universität Bochum, In der Schornau 23-25, 44892 Bochum, Germany. Email: 
a_budihardja@hotmail.com
FULL RECORD ENTRY DATE
  2008-05-21
SOURCE
  Mund - Kiefer - und Gesichtschirurgie (2007) 11:6 (363-367). Date of 
Publication: December 2007
VOLUME
  11
ISSUE
  6
FIRST PAGE
  363
LAST PAGE
  367
DATE OF PUBLICATION
  December 2007
ISSN
  1432-9417
  1434-3940 (electronic)
BOOK PUBLISHER
  Springer Verlag
ABSTRACT
  Mechanical airway obstruction secondary to retropharyngeal bleeding is rare. 
In most cases such a complication is described after head and neck trauma. 
Complicating factors include anticoagulant therapy, tumour, aneurysm, 
infection or major cervical spine injury. A precise initial diagnosis is 
necessary to avoid a life-threatening situation. Lateral X-ray and computed 
tomography is essential for safe management. Treatment depends upon size of 
the haematoma as well as the clinical course of the patient. Smaller 
haematomas may be observed. Lager haematomas and those that fail to reabsorb 
should undergo drainage. © Springer-Verlag 2007.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (etiology, therapy); blunt trauma (complication, therapy); hematoma (complication, therapy); neck injury (complication, therapy); pharynx disease (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; contrast medium extravasation; human; image processing; injury; intensive care; male; neck muscle; radiography; spiral computer assisted tomography; tracheostomy; 
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  German, English
MEDLINE PMID
  17990011 (http://www.ncbi.nlm.nih.gov/pubmed/17990011)
PUI
  L350193566
DOI
  10.1007/s10006-007-0085-1
FULL TEXT LINK
  http://dx.doi.org/10.1007/s10006-007-0085-1
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14329417&id=doi:10.1007%2Fs10006-007-0085-1&atitle=Severe+upper+airway+obstruction+due+to+retropharyngeal+haematoma+formation+following+cervical+trauma&stitle=Mund.+Kiefer.+Gesichtschir.&title=Mund+-+Kiefer+-+und+Gesichtschirurgie&volume=11&issue=6&spage=363&epage=367&aulast=Haarmann&aufirst=Stephan&auinit=S.&aufull=Haarmann+S.&coden=&isbn=&pages=363-367&date=2007&auinit1=S&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 833
TITLE
  Pitfalls in treatment of acute cervical spinal cord injury using high-dose 
methylprednisolone: a retrospect audit of 111 patients
AUTHOR NAMES
  Lee H.-C.; Cho D.-Y.; Lee W.-Y.; Chuang H.-C.
AUTHOR ADDRESSES
  (Lee H.-C.; Cho D.-Y., braintumorgbm@yahoo.com.tw; Lee W.-Y.; Chuang H.-C.) 
Department of Neurosurgery, China Medical University Hospital, Taichung, 
404, Taiwan.
CORRESPONDENCE ADDRESS
  D.-Y. Cho, Department of Neurosurgery, China Medical University Hospital, 
Taichung, 404, Taiwan. Email: braintumorgbm@yahoo.com.tw
FULL RECORD ENTRY DATE
  2007-11-01
SOURCE
  Surgical Neurology (2007) 68:5 SUPPL. (S37-S41). Date of Publication: 
November 2007
VOLUME
  68
ISSUE
  5 SUPPL.
DATE OF PUBLICATION
  November 2007
ISSN
  0090-3019
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Background: Earlier studies suggested that the use of high-dose IV MP was 
the gold standard of care for the treatment of ASCI, but this has been 
debated. This study aims to identify the effects of high-dose MP in 
treatment of cervical SCI and how the treatment might be improved. Methods: 
The medical records of 138 patients with cervical spinal injury secondary to 
blunt injuries were retrospectively reviewed to determine the steroid 
administration protocol, effects, and complications. The findings on 
admission were compared with those at discharge and at the most recent 
outpatient follow-up visit. Significant neurologic improvement was defined 
as increase in at least 1 clinical grade according to the Frankel 
classification system. Results: Significantly more motor and sensory 
recovery was noted (complete ASCI, 69% vs 0; incomplete ASCI, 70% vs 50%) in 
patients treated with surgery and MP than in patients without such 
treatment. Moreover, 87% (14/16) of patients with complete ASCI (unlike 
patients with incomplete [8/28, 28.6%] and mild [2/14, 14.3%] ASCI) treated 
with MP had steroid-related complications, and 1 patient died from sepsis 
related to a perforated peptic ulcer. Mean hospitalization was significantly 
shorter for the patients who underwent tracheostomy (49 days, ranged from 22 
to 110 days) vs nontracheostomy(94 days, ranged from 28-268 days). 
Conclusion: Early intervention with surgery and MP is critical. Although 
treatment with MP for 24 or 48 hours significantly improves motor and 
sensory function of patients with ASCI, harmful side effects limit its 
functional efficacy in patients with complete ASCI. Early tracheostomy can 
shorten hospital stay in patients with complete ASCI. © 2007 Elsevier Inc. 
All rights reserved.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  methylprednisolone (adverse drug reaction, drug dose, drug therapy, 
intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (drug therapy, epidemiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; controlled study; disease course; disease severity; drug effect; drug efficacy; drug megadose; female; follow up; hospitalization; human; major clinical study; male; medical record; motor performance; neurologic examination; outcome assessment; peptic ulcer (side effect); school child; sensory evaluation; sepsis (complication); spinal cord decompression; survival rate; tracheostomy; treatment failure; treatment outcome; unspecified side effect (side effect); 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007508944
MEDLINE PMID
  17963919 (http://www.ncbi.nlm.nih.gov/pubmed/17963919)
PUI
  L47600303
DOI
  10.1016/j.surneu.2007.06.085
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.surneu.2007.06.085
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903019&id=doi:10.1016%2Fj.surneu.2007.06.085&atitle=Pitfalls+in+treatment+of+acute+cervical+spinal+cord+injury+using+high-dose+methylprednisolone%3A+a+retrospect+audit+of+111+patients&stitle=Surg.+Neurol.&title=Surgical+Neurology&volume=68&issue=5+SUPPL.&spage=&epage=&aulast=Lee&aufirst=Han-Chung&auinit=H.-C.&aufull=Lee+H.-C.&coden=SGNRA&isbn=&pages=-&date=2007&auinit1=H&auinitm=-C
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 834
TITLE
  Two cases of myelopathy highlight the importance of investigating weakness 
in ICU
AUTHOR NAMES
  Plunkett E.V.E.; Seyfried O.; Mateen M.; Ghosh I.R.
AUTHOR ADDRESSES
  (Plunkett E.V.E.; Seyfried O.; Ghosh I.R., IRGhosh@aol.com) Intensive Care 
Unit, Homerton University Hospital, London, United Kingdom.
(Mateen M.) Department of Radiology, Homerton University Hospital, London, 
United Kingdom.
(Ghosh I.R., IRGhosh@aol.com) Intensive Care Unit, Homerton University 
Hospital, Homerton Row, London E9 6SR, United Kingdom.
CORRESPONDENCE ADDRESS
  I.R. Ghosh, Intensive Care Unit, Homerton University Hospital, Homerton Row, 
London E9 6SR, United Kingdom. Email: IRGhosh@aol.com
FULL RECORD ENTRY DATE
  2007-09-01
SOURCE
  British Journal of Intensive Care (2007) 17:3 (102-105). Date of 
Publication: Autumn 2007
VOLUME
  17
ISSUE
  3
FIRST PAGE
  102
LAST PAGE
  105
DATE OF PUBLICATION
  Autumn 2007
ISSN
  0961-7930
BOOK PUBLISHER
  Greycoat Publishing, 120 Dawes Road, London, United Kingdom.
ABSTRACT
  Two myelopathic cases highlight the importance of investigation of weakness 
in intensive care. In both cases evidence of weakness prompted imaging which 
confirmed the diagnosis. E Plunkett et al. recommend that all cases of 
weakness be investigated; the detection of neurological deficits coexisting 
with critical illness may enable either specific therapy to improve outlook, 
or the timely confirmation of a goarded outlook.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord disease (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; article; case report; chronic obstructive lung disease (diagnosis, therapy); female; human; intensive care unit; male; mastoiditis (complication); multiple organ failure; nuclear magnetic resonance imaging; renal replacement therapy; septicemia (complication); Staphylococcus aureus; tracheostomy; 
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007516323
PUI
  L47621693
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09617930&id=doi:&atitle=Two+cases+of+myelopathy+highlight+the+importance+of+investigating+weakness+in+ICU&stitle=Br.+J.+Intensive+Care&title=British+Journal+of+Intensive+Care&volume=17&issue=3&spage=102&epage=105&aulast=Plunkett&aufirst=E.V.E.&auinit=E.V.E.&aufull=Plunkett+E.V.E.&coden=BJICE&isbn=&pages=102-105&date=2007&auinit1=E&auinitm=V.E.
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 835
TITLE
  Paraplegia as a result of tracheal resection in a 17-year-old male
AUTHOR NAMES
  Silver J.R.
AUTHOR ADDRESSES
  (Silver J.R.) National Spinal Injuries Centre, Wendover, Bucks, United 
Kingdom.
(Silver J.R.) National Spinal Injuries Centre, 8 High Street, Wendover, 
Bucks, HP22 6EA, United Kingdom.
CORRESPONDENCE ADDRESS
  J.R. Silver, National Spinal Injuries Centre, 8 High Street, Wendover, 
Bucks, HP22 6EA, United Kingdom.
FULL RECORD ENTRY DATE
  2007-08-17
SOURCE
  Spinal Cord (2007) 45:8 (576-578). Date of Publication: 17 Aug 2007
VOLUME
  45
ISSUE
  8
FIRST PAGE
  576
LAST PAGE
  578
DATE OF PUBLICATION
  17 Aug 2007
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Case report and literature review. Setting: Outpatient review 
in the UK on a young male from the USA. Objectives: To report on a healthy 
young male who developed an incomplete paraplegia following flexion of the 
cervical spine after surgery to relieve tracheal stenosis. Conclusion: 
Spinal cord injury following prolonged flexion of the cervical spine after 
surgery to relieve tracheal stenosis can cause paraplegia. The postulated 
mechanism is traction upon the thoracic cord. © 2007 International Spinal 
Cord Society All rights reserved.
EMTREE DRUG INDEX TERMS
  gadolinium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  paraplegia (complication); spinal cord disease (diagnosis); trachea stenosis (surgery); vascular myelopathy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adolescent; anamnesis; article; case report; cervical spine; flexor reflex; hospital discharge; human; male; medical literature; nuclear magnetic resonance imaging; outpatient; patient referral; priority journal; thoracic spinal cord; trachea resection; tracheostomy; treatment outcome; United Kingdom; United States; 
CAS REGISTRY NUMBERS
  gadolinium (7440-54-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007383626
MEDLINE PMID
  17091121 (http://www.ncbi.nlm.nih.gov/pubmed/17091121)
PUI
  L47206961
DOI
  10.1038/sj.sc.3101985
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3101985
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3101985&atitle=Paraplegia+as+a+result+of+tracheal+resection+in+a+17-year-old+male&stitle=Spinal+Cord&title=Spinal+Cord&volume=45&issue=8&spage=576&epage=578&aulast=Silver&aufirst=J.R.&auinit=J.R.&aufull=Silver+J.R.&coden=SPCOF&isbn=&pages=576-578&date=2007&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 836
TITLE
  Penetrating injury of the upper cervical spine by a chopstick - Case report
AUTHOR NAMES
  Yamaguchi S.; Eguchi K.; Takeda M.; Hidaka T.; Shrestha P.; Kurisu K.
AUTHOR ADDRESSES
  (Yamaguchi S., satjp02@yahoo.co.jp; Eguchi K.; Takeda M.; Hidaka T.; 
Shrestha P.; Kurisu K.) Department of Neurosurgery, Hiroshima University, 
Graduate School of Biomedical Sciences, Hiroshima, Japan.
(Yamaguchi S., satjp02@yahoo.co.jp) Department of Neurosurgery, Hiroshima 
University, Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 
Hiroshima 734-8551, Japan.
CORRESPONDENCE ADDRESS
  S. Yamaguchi, Department of Neurosurgery, Hiroshima University, Graduate 
School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, 
Japan. Email: satjp02@yahoo.co.jp
FULL RECORD ENTRY DATE
  2007-08-09
SOURCE
  Neurologia Medico-Chirurgica (2007) 47:7 (328-330). Date of Publication: 
2007
VOLUME
  47
ISSUE
  7
FIRST PAGE
  328
LAST PAGE
  330
DATE OF PUBLICATION
  2007
ISSN
  0470-8105
  1349-8029 (electronic)
BOOK PUBLISHER
  Japan Neurosurgical Society, 5-25-16 Hongo, Bunkyo-ku, Tokyo, Japan.
ABSTRACT
  A 35-year-old man presented with penetrating spinal injury after attempting 
suicide by stabbing a wooden chopstick into his mouth. The object penetrated 
the pharynx, and the tip entered the spinal canal of the atlantoaxial 
vertebrae. Emergent surgery disclosed that the tip of the chopstick had 
penetrated between the dural sac and the vertebral artery. There was no 
dural tear or vertebral artery injury. The foreign body was removed 
successfully from the oral side. He recovered without neurological sequelae.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (surgery); penetrating trauma (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; chopstick; clinical examination; clinical feature; emergency surgery; foreign body; human; laminectomy; male; neurologic examination; nuclear magnetic resonance imaging; postoperative period; stab wound; suicide attempt; tracheotomy; treatment outcome; vertebral artery; wood; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Radiology (14)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007373057
MEDLINE PMID
  17652922 (http://www.ncbi.nlm.nih.gov/pubmed/17652922)
PUI
  L47173927
DOI
  10.2176/nmc.47.328
FULL TEXT LINK
  http://dx.doi.org/10.2176/nmc.47.328
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=04708105&id=doi:10.2176%2Fnmc.47.328&atitle=Penetrating+injury+of+the+upper+cervical+spine+by+a+chopstick+-+Case+report&stitle=Neurol.+Med.-Chir.&title=Neurologia+Medico-Chirurgica&volume=47&issue=7&spage=328&epage=330&aulast=Yamaguchi&aufirst=Satoshi&auinit=S.&aufull=Yamaguchi+S.&coden=NMCHB&isbn=&pages=328-330&date=2007&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 837
TITLE
  Extensive endobronchial calcification contributing to hypoxia in a 
quadriplegic patient [33]
AUTHOR NAMES
  Imberti R.; Pricca P.; Pietrobono L.; Langer M.
AUTHOR ADDRESSES
  (Imberti R., r.imberti@smatteo.pv.it) 2nd Department of Anesthesiology and 
Critical Care Medicine, Fondazione IRCCS Policlinico S. Matteo, Pavia, 
Italy.
(Pricca P.; Pietrobono L.) Department of Radiology, Fondazione IRCCS 
Policlinico S. Matteo, Pavia, Italy.
(Langer M.) Department of Anesthesiology and Critical Care Medicine, 
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
CORRESPONDENCE ADDRESS
  R. Imberti, 2nd Department of Anesthesiology and Critical Care Medicine, 
Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. Email: 
r.imberti@smatteo.pv.it
FULL RECORD ENTRY DATE
  2007-08-01
SOURCE
  Anesthesia and Analgesia (2007) 105:2 (551-552). Date of Publication: August 
2007
VOLUME
  105
ISSUE
  2
FIRST PAGE
  551
LAST PAGE
  552
DATE OF PUBLICATION
  August 2007
ISSN
  0003-2999
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchiole; calcification (complication, diagnosis, surgery); hypoxia (etiology); small airway disease (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; bronchus obstruction (complication, diagnosis, surgery); case report; computer assisted tomography; human; letter; male; oxygenation; priority journal; quadriplegia; spinal cord injury; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007379655
MEDLINE PMID
  17646542 (http://www.ncbi.nlm.nih.gov/pubmed/17646542)
PUI
  L47196474
DOI
  10.1213/01.ane.0000265697.58845.fd
FULL TEXT LINK
  http://dx.doi.org/10.1213/01.ane.0000265697.58845.fd
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032999&id=doi:10.1213%2F01.ane.0000265697.58845.fd&atitle=Extensive+endobronchial+calcification+contributing+to+hypoxia+in+a+quadriplegic+patient+%5B33%5D&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=105&issue=2&spage=551&epage=552&aulast=Imberti&aufirst=Roberto&auinit=R.&aufull=Imberti+R.&coden=AACRA&isbn=&pages=551-552&date=2007&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 838
TITLE
  Cervical hematoma after discectomy for spondylosis. An indication of urgent 
tracheotomy
ORIGINAL (NON-ENGLISH) TITLE
  Hematoma cervical tras disquectomía por espondilosis. Indicación de 
Traqueotomía Urgente.
AUTHOR NAMES
  Pino Rivero V.; Pantoja Hernández C.G.; Mora Santos M.E.; Gonzalez Palomino A.; Ambel Albarrán A.; Rodríguez Sánchez J.A.; Blasco Huelva A.
AUTHOR ADDRESSES
  (Pino Rivero V.; Pantoja Hernández C.G.; Mora Santos M.E.; Gonzalez Palomino 
A.; Ambel Albarrán A.; Rodríguez Sánchez J.A.; Blasco Huelva A.) Facultativo 
Especialista de Otorrinolaringología, Complejo Hospitalario Infanta 
Cristina.
CORRESPONDENCE ADDRESS
  V. Pino Rivero, Facultativo Especialista de Otorrinolaringología, Complejo 
Hospitalario Infanta Cristina. Email: vicentepinorivero@terra.com
FULL RECORD ENTRY DATE
  2007-07-22
SOURCE
  Anales otorrinolaringológicos ibero-americanos (2007) 34:2 (105-110). Date 
of Publication: 2007
VOLUME
  34
ISSUE
  2
FIRST PAGE
  105
LAST PAGE
  110
DATE OF PUBLICATION
  2007
ISSN
  0303-8874
ABSTRACT
  We report the clinical case of a hematoma after surgery of cervical 
spondylosis which required an urgent tracheotomy due to failure in the 
orotracheal intubation. This illness in advanced degree, so called cervical 
spondylotic myelopathy, is the most serious consequence of cervical 
intervertebral disc degeneration.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine (surgery); hematoma (etiology, surgery); postoperative complication; spondylosis (surgery); tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; human; male; nuclear magnetic resonance imaging; pathology; respiratory failure (etiology); 
LANGUAGE OF ARTICLE
  Spanish
MEDLINE PMID
  17549957 (http://www.ncbi.nlm.nih.gov/pubmed/17549957)
PUI
  L47071087
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03038874&id=doi:&atitle=Cervical+hematoma+after+discectomy+for+spondylosis.+An+indication+of+urgent+tracheotomy&stitle=An+Otorrinolaringol+Ibero+Am&title=Anales+otorrinolaringol%C3%B3gicos+ibero-americanos&volume=34&issue=2&spage=105&epage=110&aulast=Pino+Rivero&aufirst=V.&auinit=V.&aufull=Pino+Rivero+V.&coden=&isbn=&pages=105-110&date=2007&auinit1=V&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 839
TITLE
  Survey of use of the insufflator-exsufflator in patients with spinal cord 
injury
AUTHOR NAMES
  Schmitt J.K.; Stiens S.; Trincher R.; Lam M.; Sarkarati M.; Linder S.; Ho C.H.
AUTHOR ADDRESSES
  (Schmitt J.K., Deborah.elder@va.gov) Hunter Holmes VA Medical Center, 
Richmond, VA, United States.
(Stiens S.) Hunter Holmes VA Medical Center, Seattle, WA, United States.
(Trincher R.) Hunter Holmes VA Medical Center, Augusta, GA, United States.
(Lam M.) Hunter Holmes VA Medical Center, West Orange, NJ, United States.
(Sarkarati M.) Hunter Holmes VA Medical Center, Woburn, MA, United States.
(Linder S.) Palo Alto VA Medical Center, Palo Alto, CA, United States.
(Ho C.H.) Palo Alto VA Medical Center, Cleveland, OH, United States.
(Schmitt J.K., Deborah.elder@va.gov) Department of Internal Medicine, H. H. 
McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23113, 
United States.
CORRESPONDENCE ADDRESS
  J.K. Schmitt, Department of Internal Medicine, H. H. McGuire VA Medical 
Center, 1201 Broad Rock Boulevard, Richmond, VA 23113, United States. Email: 
Deborah.elder@va.gov
FULL RECORD ENTRY DATE
  2007-07-09
SOURCE
  Journal of Spinal Cord Medicine (2007) 30:2 (127-130). Date of Publication: 
2007
VOLUME
  30
ISSUE
  2
FIRST PAGE
  127
LAST PAGE
  130
DATE OF PUBLICATION
  2007
ISSN
  1079-0268
BOOK PUBLISHER
  American Paraplegia Society, 75-20 Astoria Boulevard, Jackson Heights, 
United States.
ABSTRACT
  Background/Objective: The insufflator-exsufflator has been shown to be 
effective in assisting cough in individuals with spinal cord injury. 
However, many institutions do not use this device. The study was performed 
to assess use of the device and attitudes among health care providers. 
Methods: We developed a questionnaire with 4 categories of questions: 
knowledge of the device, type of facility, clinical practice with the 
device, and patient and provider satisfaction. The questionnaire was mailed 
to members of the American Paraplegia Society. Results: Eighty-six 
questionnaires (16%) were returned. The device was being used in 49% of the 
institutions. The device was most commonly used with a tracheostomy; use did 
not correlate with size or type of facility. Patient and provider 
satisfaction with the insufflator-exsufflator was high. Conclusions: The 
insufflator-exsufflator is used as a means of removal of secretions in 
approximately one half of institutions polled. Satisfaction with the device 
is high.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  abdominal discomfort (complication); aeration; article; bradycardia (complication); coughing; devices; health care delivery; health care personnel; health personnel attitude; human; nausea (complication); paraplegia; patient care; patient satisfaction; questionnaire; tachycardia (complication); technical aid; thorax pressure; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007297520
MEDLINE PMID
  17591224 (http://www.ncbi.nlm.nih.gov/pubmed/17591224)
PUI
  L46942227
DOI
  10.1080/10790268.2007.11753923
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2007.11753923
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2007.11753923&atitle=Survey+of+use+of+the+insufflator-exsufflator+in+patients+with+spinal+cord+injury&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=30&issue=2&spage=127&epage=130&aulast=Schmitt&aufirst=James+K.&auinit=J.K.&aufull=Schmitt+J.K.&coden=JSCMC&isbn=&pages=127-130&date=2007&auinit1=J&auinitm=K
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 840
TITLE
  Spinal muscular atrophy type 1: Is long-term mechanical ventilation ethical? 
Commentary
AUTHOR NAMES
  Ryan M.
AUTHOR ADDRESSES
  (Ryan M.)
FULL RECORD ENTRY DATE
  2007-04-01
SOURCE
  Journal of Paediatrics and Child Health (2007) 43:4 (237-238). Date of 
Publication: April 2007
VOLUME
  43
ISSUE
  4
FIRST PAGE
  237
LAST PAGE
  238
DATE OF PUBLICATION
  April 2007
ISSN
  1034-4810
  1440-1754 (electronic)
BOOK PUBLISHER
  Blackwell Publishing, 550 Swanston Street, Carlton South, Australia.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; respiratory failure (therapy); spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  disease course; face mask; human; note; phenotype; priority journal; survival; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007177205
PUI
  L46570084
DOI
  10.1111/j.1440-1754.2007.01052.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1440-1754.2007.01052.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10344810&id=doi:10.1111%2Fj.1440-1754.2007.01052.x&atitle=Spinal+muscular+atrophy+type+1%3A+Is+long-term+mechanical+ventilation+ethical%3F+Commentary&stitle=J.+Paediatr.+Child+Health&title=Journal+of+Paediatrics+and+Child+Health&volume=43&issue=4&spage=237&epage=238&aulast=Ryan&aufirst=Monique&auinit=M.&aufull=Ryan+M.&coden=JPCHE&isbn=&pages=237-238&date=2007&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 841
TITLE
  Spinal muscular atrophy type 1: Is long-term mechanical ventilation ethical? 
Commentary
AUTHOR NAMES
  Jacobe S.
AUTHOR ADDRESSES
  (Jacobe S.)
FULL RECORD ENTRY DATE
  2007-04-01
SOURCE
  Journal of Paediatrics and Child Health (2007) 43:4 (238). Date of 
Publication: April 2007
VOLUME
  43
ISSUE
  4
FIRST PAGE
  238
DATE OF PUBLICATION
  April 2007
ISSN
  1034-4810
  1440-1754 (electronic)
BOOK PUBLISHER
  Blackwell Publishing, 550 Swanston Street, Carlton South, Australia.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; respiratory failure (therapy); spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  critical illness; disability; human; intensive care; long term care; medical ethics; medical specialist; note; parental attitude; priority journal; tracheotomy; treatment withdrawal; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007177206
PUI
  L46570085
DOI
  10.1111/j.1440-1754.2007.01052.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1440-1754.2007.01052.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10344810&id=doi:10.1111%2Fj.1440-1754.2007.01052.x&atitle=Spinal+muscular+atrophy+type+1%3A+Is+long-term+mechanical+ventilation+ethical%3F+Commentary&stitle=J.+Paediatr.+Child+Health&title=Journal+of+Paediatrics+and+Child+Health&volume=43&issue=4&spage=238&epage=&aulast=Jacobe&aufirst=Stephen&auinit=S.&aufull=Jacobe+S.&coden=JPCHE&isbn=&pages=238-&date=2007&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 842
TITLE
  Spinal muscular atrophy type 1: Is long-term mechanical ventilation ethical? 
Commentary
AUTHOR NAMES
  Isaacs D.
AUTHOR ADDRESSES
  (Isaacs D.)
FULL RECORD ENTRY DATE
  2007-04-01
SOURCE
  Journal of Paediatrics and Child Health (2007) 43:4 (239-240). Date of 
Publication: April 2007
VOLUME
  43
ISSUE
  4
FIRST PAGE
  239
LAST PAGE
  240
DATE OF PUBLICATION
  April 2007
ISSN
  1034-4810
  1440-1754 (electronic)
BOOK PUBLISHER
  Blackwell Publishing, 550 Swanston Street, Carlton South, Australia.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; respiratory failure (therapy); spinal muscular atrophy (disease management); 
EMTREE MEDICAL INDEX TERMS
  caregiver; conflict; counseling; disability; feeding tube; hospital personnel; human; intensive care; note; palliative therapy; parental attitude; pediatrician; priority journal; quality of life; tracheostomy; treatment withdrawal; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007177208
PUI
  L46570087
DOI
  10.1111/j.1440-1754.2007.01052.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1440-1754.2007.01052.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10344810&id=doi:10.1111%2Fj.1440-1754.2007.01052.x&atitle=Spinal+muscular+atrophy+type+1%3A+Is+long-term+mechanical+ventilation+ethical%3F+Commentary&stitle=J.+Paediatr.+Child+Health&title=Journal+of+Paediatrics+and+Child+Health&volume=43&issue=4&spage=239&epage=240&aulast=Isaacs&aufirst=David&auinit=D.&aufull=Isaacs+D.&coden=JPCHE&isbn=&pages=239-240&date=2007&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 843
TITLE
  Surgical strategy for severe cervical spine dislocations
AUTHOR NAMES
  Wang X.W.; Yuan W.; Chen D.Y.; Chen X.S.; Zhou X.H.; Ye X.J.; Chen H.J.; Han Z.; Kang J.
AUTHOR ADDRESSES
  (Wang X.W.; Yuan W.; Chen D.Y.; Chen X.S.; Zhou X.H.; Ye X.J.; Chen H.J.; 
Han Z.; Kang J.) Department of Orthopedics, Changzheng Hospital, Second 
Military Medical University, Shanghai 200003, China.
CORRESPONDENCE ADDRESS
  X.W. Wang, Department of Orthopedics, Changzheng Hospital, Second Military 
Medical University, Shanghai 200003, China.
FULL RECORD ENTRY DATE
  2008-08-25
SOURCE
  Zhonghua wai ke za zhi [Chinese journal of surgery] (2007) 45:6 (379-382). 
Date of Publication: 15 Mar 2007
VOLUME
  45
ISSUE
  6
FIRST PAGE
  379
LAST PAGE
  382
DATE OF PUBLICATION
  15 Mar 2007
ISSN
  0529-5815
ABSTRACT
  OBJECTIVE: To evaluate the rate of open reduction and surgical strategy of 
severe cervical dislocation. METHODS: From March 2001 to March 2006, the 
data of 92 cases of cervical dislocation over 1/2 were retrospectively 
studied. Garden Well traction with 1 - 3 kg weight were performed before 
operation. The patients were performed with diskectomy and reduction with 
anterior approach initially, for those that can not be reduced, corpectomy 
were performed and reduction procedures were repeated. The posterior 
reduction and fixation were followed when reduction can not be reached with 
anterior approach only. The succeed rate of reduction, rate of tracheotomy 
were recorded and fusion rate, Frankel score and visual analog scale (VAS) 
were evaluated. RESULTS: Reduction succeed in 38 cases after diskectomy, 44 
after corpectomy and 7 after combined anterior-posterior-anterior procedure. 
Three cases got incompleteness reduction. Tracheotomy was done in 29 cases. 
The Frankel score increased 0.5 degree and VAS was 2 averagely at the last 
follow-up. CONCLUSIONS: The succeed rate of anterior open reduction was 
89.2%, and only 10.8% patients needs an additional combined posterior and 
anterior approach. For patients with completed spinal cord injury with 
dislocation above C(4), or with dislocation below C(5) but the edema on MRI 
T2 image are above C(4) level need tracheotomy. The operation be done until 
respiratory function stable. For patients with completed spinal cord injury 
with dislocation below C(4) and uncompleted spinal cord injury with 
dislocation above C(4), the rate of tracheotomy is relatively lower and 
early operation is recommended.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; decompression surgery; dislocation (complication, surgery); osteosynthesis; spine fracture (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  article; bone transplantation; discectomy; female; follow up; human; injury; laminectomy; male; methodology; retrospective study; spine fusion; traction therapy; treatment outcome; 
LANGUAGE OF ARTICLE
  Chinese
MEDLINE PMID
  17537321 (http://www.ncbi.nlm.nih.gov/pubmed/17537321)
PUI
  L350352773
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=05295815&id=doi:&atitle=Surgical+strategy+for+severe+cervical+spine+dislocations&stitle=Zhonghua+Wai+Ke+Za+Zhi&title=Zhonghua+wai+ke+za+zhi+%5BChinese+journal+of+surgery%5D&volume=45&issue=6&spage=379&epage=382&aulast=Wang&aufirst=Xin-wei&auinit=X.W.&aufull=Wang+X.W.&coden=&isbn=&pages=379-382&date=2007&auinit1=X&auinitm=W
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 844
TITLE
  Ventilatory dysfunction in motor neuron disease: When and how to act?
ORIGINAL (NON-ENGLISH) TITLE
  Disfunção ventilatória na doença do neurónio motor: Quando e como intervir?
AUTHOR NAMES
  Rocha J.A.; Miranda M.J.
AUTHOR ADDRESSES
  (Rocha J.A.; Miranda M.J.)
FULL RECORD ENTRY DATE
  2007-03-01
SOURCE
  Acta Medica Portuguesa (2007) 20:2 (157-166). Date of Publication: 
March/April 2007
VOLUME
  20
ISSUE
  2
FIRST PAGE
  157
LAST PAGE
  166
DATE OF PUBLICATION
  March/April 2007
ISSN
  1646-0758 (electronic)
BOOK PUBLISHER
  Centro Editor Livreiro da Ordem dos Medicos, Avenida Almirante Reis 242 Esq, 
Lisbon, Portugal.
ABSTRACT
  Amyotrophic lateral sclerosis is a devastating progressive neurodegenerative 
disorder, involving motor neurons in the cerebral cortex, brainstem and 
spinal cord. Mean duration of survival from the time of diagnosis is around 
15 months, being pulmonary complications and respiratory failure responsible 
for more than 85% of deaths. Albeit the inevitability of respiratory failure 
and short-term death, standardized intervention protocols have been shown to 
significantly delay the need for invasive ventilatory support, thus 
prolonging survival and enhancing quality of life. The authors present an 
intervention protocol based on clinical progression and respiratory 
parameters. Decisions regarding initiation of non-invasive positive pressure 
ventilation (NIPPV) and mechanically assisted coughing, depend on 
development of symptoms of hypoventilation and on objective deteoration of 
respiratory parameters especially in what concerns bulbar muscle function. 
These include maximum inspiratory capacity (MIC), difference between MIC and 
vital capacity (MIC-VC), and assisted peak cough flow (PCF). These 
standardized protocols along with patient and caregivers education, allow 
for improved quality of life, prolonged survival and delay or eventually 
prevent the need for tracheotomy and invasive ventilatory support. 
Supplemental oxygen should be avoided in these patients, since it precludes 
use of oxymetry as feedback for titrating NIPPV and MAC, and is associated 
with decreased ventilatory drive and aggravated hypercapnia.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (disease management); respiratory failure (complication, disease management, therapy); 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; disease association; human; lung ventilation; mortality; motor neuron disease; quality of life; review; survival; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  Portuguese
LANGUAGE OF SUMMARY
  English, Portuguese
EMBASE ACCESSION NUMBER
  2007392735
MEDLINE PMID
  17868522 (http://www.ncbi.nlm.nih.gov/pubmed/17868522)
PUI
  L47235131
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16460758&id=doi:&atitle=Ventilatory+dysfunction+in+motor+neuron+disease%3A+When+and+how+to+act%3F&stitle=Acta+Med.+Port.&title=Acta+Medica+Portuguesa&volume=20&issue=2&spage=157&epage=166&aulast=Rocha&aufirst=J.+Afonso&auinit=J.A.&aufull=Rocha+J.A.&coden=AMPOD&isbn=&pages=157-166&date=2007&auinit1=J&auinitm=A
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 845
TITLE
  Variability in rates of arthrodesis procedures for patients with cervical 
spine injuries with and without associated spinal cord injury
AUTHOR NAMES
  Daniels A.H.; Arthur M.; Hart R.A.
AUTHOR ADDRESSES
  (Daniels A.H.) Apartment 43, 3050 S.W. 10th Avenue, Portland, OR 97239, 
United States.
(Arthur M.) Department of Sociology, Portland State University, P.O. Box 
751, Portland, OR 97207, United States.
(Hart R.A., hartro@ohsu.edu) Department of Orthopaedics and Rehabilitation, 
Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, 
Portland, OR 97201, United States.
CORRESPONDENCE ADDRESS
  A.H. Daniels, Apartment 43, 3050 S.W. 10th Avenue, Portland, OR 97239, 
United States.
FULL RECORD ENTRY DATE
  2007-03-06
SOURCE
  Journal of Bone and Joint Surgery - Series A (2007) 89:2 (317-323). Date of 
Publication: February 2007
VOLUME
  89
ISSUE
  2
FIRST PAGE
  317
LAST PAGE
  323
DATE OF PUBLICATION
  February 2007
ISSN
  0021-9355
BOOK PUBLISHER
  Journal of Bone and Joint Surgery Inc., 20 Pickering Street, Needham, United 
States.
ABSTRACT
  Background: Cervical spine injury, with or without spinal cord injury, is an 
important cause of morbidity and mortality in the United States. While 
substantial regional variation has been shown in per capita rates of 
elective cervical spine surgery, similar data regarding arthrodesis rates 
for traumatic cervical injury have not been reported, to our knowledge. We 
assessed the rates of cervical spinal arthrodesis for patients who had a 
cervical spine injury with or without an associated spinal cord injury. 
Methods: The data for the present study came from the Healthcare Cost and 
Utilization Project Nationwide Inpatient Sample from 1998 to 2002. 
International Classification of Diseases, Ninth Revision, Clinical 
Modification codes were used to identify patients with a cervical vertebral 
fracture or dislocation with or without an associated spinal cord injury. 
Hospitals were grouped according to their teaching status, location (urban 
or rural), and volume of cervical spine injury patients. The rates of spinal 
arthrodesis and halo/tong placement were compared for patients within each 
diagnostic category. Results: Twenty-eight thousand, five hundred and 
eighteen patients with a cervical spine injury were analyzed. Spinal 
arthrodesis was performed for 16.5% of patients who had a cervical fracture 
without an associated spinal cord injury, for 50.4% of patients who had a 
cervical spine fracture with an associated spinal cord injury, and for 44.1% 
of patients who had a cervical dislocation. With the numbers available, the 
rates of arthrodesis for patients who had a fracture without a spinal cord 
injury and for patients who had a cervical dislocation were not 
significantly different between high and low-volume centers, although the 
rate for patients who had a cervical fracture with a spinal cord injury was 
significantly higher at high-volume hospitals. The rates of arthrodesis did 
not vary significantly between urban teaching and nonteaching hospitals, 
with the numbers available, for patients in any of the three diagnostic 
categories. Individual hospitals had a threefold to fivefold variation in 
the arthrodesis rate for patients with a cervical spine injury, depending on 
the diagnostic category. Conclusions: The present study demonstrated 
substantial differences in the rate of arthrodesis for patients with 
cervical spine trauma, depending on the diagnostic category. The variations 
in the rates of arthrodesis within diagnostic categories appear to be lower 
than the previously reported variation in the rates of elective cervical 
spine procedures. Copyright © 2007 by The Journal of Bone and Joint Surgery, 
Incorporated.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arthrodesis; cervical spinal cord injury; cervical spine fracture (disease management, surgery); cervical spine injury (disease management, surgery); 
EMTREE MEDICAL INDEX TERMS
  article; health care cost; health care utilization; hospitalization; human; International Classification of Diseases; major clinical study; orthosis; priority journal; scoring system; spinal cord injury; spine fracture (disease management, surgery); spine injury (disease management, surgery); spine surgery; teaching hospital; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007075199
MEDLINE PMID
  17272446 (http://www.ncbi.nlm.nih.gov/pubmed/17272446)
PUI
  L46214350
DOI
  10.2106/JBJS.F.00790
FULL TEXT LINK
  http://dx.doi.org/10.2106/JBJS.F.00790
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00219355&id=doi:10.2106%2FJBJS.F.00790&atitle=Variability+in+rates+of+arthrodesis+procedures+for+patients+with+cervical+spine+injuries+with+and+without+associated+spinal+cord+injury&stitle=J.+Bone+Jt.+Surg.+Ser.+A&title=Journal+of+Bone+and+Joint+Surgery+-+Series+A&volume=89&issue=2&spage=317&epage=323&aulast=Daniels&aufirst=Alan+H.&auinit=A.H.&aufull=Daniels+A.H.&coden=JBJSA&isbn=&pages=317-323&date=2007&auinit1=A&auinitm=H
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 846
TITLE
  Endoscopic image-guided odontoidectomy for decompression of basilar 
invagination via a standard anterior cervical approach. Technical note
AUTHOR NAMES
  Wolinsky J.-P.; Sciubba D.M.; Suk I.; Gokaslan Z.L.
AUTHOR ADDRESSES
  (Wolinsky J.-P., jwolins3@jhmi.edu; Sciubba D.M.; Suk I.; Gokaslan Z.L.) 
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, 
MD, United States.
(Wolinsky J.-P., jwolins3@jhmi.edu) Johns Hopkins University, School of 
Medicine, Meyer Building 7-109, 600 North Wolfe Street, Baltimore, MD 21287, 
United States.
CORRESPONDENCE ADDRESS
  J.-P. Wolinsky, Johns Hopkins University, School of Medicine, Meyer Building 
7-109, 600 North Wolfe Street, Baltimore, MD 21287, United States. Email: 
jwolins3@jhmi.edu
FULL RECORD ENTRY DATE
  2007-02-01
SOURCE
  Journal of Neurosurgery: Spine (2007) 6:2 (184-191). Date of Publication: 
February 2007
VOLUME
  6
ISSUE
  2
FIRST PAGE
  184
LAST PAGE
  191
DATE OF PUBLICATION
  February 2007
ISSN
  1547-5654
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Symptomatic irreducible basilar invagination has traditionally been 
approached through a transoral-transpharyngeal route with resection of the 
anterior portion of C-1 and the odontoid. Modification of this exposure with 
either a Le Fort osteotomy or a transmandibular osteotomy and circumglossal 
approach has increased the access to pathological conditions in this region. 
These traditional routes all require traversing the oral cavity and 
accepting the associated potential complications. The authors have developed 
a novel surgical approach, an endoscopic transcervical odontoidectomy, which 
allows access for resection of the odontoid and for brainstem and spinal 
cord decompression without traversing the oral cavity. In this paper they 
describe the technique and its advantages and present three cases in which 
patients underwent the endoscopic transcervical odontoidectomy for basilar 
invagination. Three consecutive patients (age range 42-74 years) who had 
irreducible basilar invagination underwent the endoscopic transcervical 
odontoidectomy. All were symptomatic and had neck pain and myelopathy. All 
were evaluated preoperatively and postoperatively with computed tomography 
and magnetic resonance imaging. In all cases the procedure resulted in 
complete decompression. There were no serious complications. No patient 
required prolonged intubation, tracheostomy, or enteral tube feeding. One 
patient had an intraoperative cerebrospinal fluid leak, which had no 
postoperative sequelae. The authors present an alternative surgical approach 
for treating ventral compression of the brainstem and spinal cord. The 
technique is safe and effective for decompression and provides a surgical 
route that can be added to the armamentarium of treatments for pathological 
conditions in this region.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain stem injury (surgery); dens axis resection; endoscopic surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; brain stem; case report; cervical spine; clinical feature; computer assisted tomography; feeding tube; female; human; intubation; liquorrhea; male; neck pain; nuclear magnetic resonance; odontoid process; postoperative care; preoperative evaluation; spinal cord decompression; spinal cord disease; spine surgery; surgical approach; surgical technique; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007343895
MEDLINE PMID
  17330590 (http://www.ncbi.nlm.nih.gov/pubmed/17330590)
PUI
  L47066067
DOI
  10.3171/spi.2007.6.2.184
FULL TEXT LINK
  http://dx.doi.org/10.3171/spi.2007.6.2.184
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15475654&id=doi:10.3171%2Fspi.2007.6.2.184&atitle=Endoscopic+image-guided+odontoidectomy+for+decompression+of+basilar+invagination+via+a+standard+anterior+cervical+approach.+Technical+note&stitle=J.+Neurosurg.+Spine&title=Journal+of+Neurosurgery%3A+Spine&volume=6&issue=2&spage=184&epage=191&aulast=Wolinsky&aufirst=Jean-Paul&auinit=J.-P.&aufull=Wolinsky+J.-P.&coden=&isbn=&pages=184-191&date=2007&auinit1=J&auinitm=-P
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 847
TITLE
  Optimal Trauma Outcome: Trauma System Design and the Trauma Team
AUTHOR NAMES
  Markovchick V.J.; Moore E.E.
AUTHOR ADDRESSES
  (Markovchick V.J., vince.markovchick@dhha.org) Emergency Medical Services, 
Denver Health, 777 Bannock Street, Denver, CO 80204, United States.
(Markovchick V.J., vince.markovchick@dhha.org) Division of Emergency 
Medicine, Department of Surgery, University of Colorado Health Sciences 
Center, 777 Bannock Street, Denver, CO 80204, United States.
(Moore E.E.) Surgery and Trauma Service, Denver Health, 777 Bannock Street, 
Denver, CO 80204, United States.
(Moore E.E.) Department of Surgery, Denver Health, 777 Bannock Street, 
Denver, CO 80204, United States.
CORRESPONDENCE ADDRESS
  V.J. Markovchick, Emergency Medical Services, Denver Health, 777 Bannock 
Street, Denver, CO 80204, United States. Email: vince.markovchick@dhha.org
FULL RECORD ENTRY DATE
  2007-08-01
SOURCE
  Emergency Medicine Clinics of North America (2007) 25:3 (643-654). Date of 
Publication: August 2007
VOLUME
  25
ISSUE
  3
FIRST PAGE
  643
LAST PAGE
  654
DATE OF PUBLICATION
  August 2007
ISSN
  0733-8627 (electronic)
  0733-8627
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  Trauma is the number one killer of Americans under age 34; optimal trauma 
care is provided when there is a well-functioning, comprehensive system. 
This article reviews the development of trauma centers in the United States, 
recommending that the number of trauma centers be optimized so that 
resources and expense be kept to a minimum. The role of specialists in the 
care of trauma patients has evolved over the past few decades. Efforts and 
protocols for trauma care should be based on objective quality outcome data, 
with the goal of making the most efficient use of resources for the best 
possible outcomes. © 2007 Elsevier Inc. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency care; injury; 
EMTREE MEDICAL INDEX TERMS
  blunt trauma; disease severity; emergency health service; emergency medicine; emergency ward; femur fracture; flail chest; Glasgow coma scale; gunshot injury; head injury; health survey; human; injury scale; neck injury; pelvis fracture; pelvis injury; penetrating trauma; priority journal; review; scoring system; spinal cord injury; thoracotomy; thorax injury; tracheotomy; United States; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007440962
MEDLINE PMID
  17826210 (http://www.ncbi.nlm.nih.gov/pubmed/17826210)
PUI
  L47376663
DOI
  10.1016/j.emc.2007.07.002
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.emc.2007.07.002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07338627&id=doi:10.1016%2Fj.emc.2007.07.002&atitle=Optimal+Trauma+Outcome%3A+Trauma+System+Design+and+the+Trauma+Team&stitle=Emerg.+Med.+Clin.+North+Am.&title=Emergency+Medicine+Clinics+of+North+America&volume=25&issue=3&spage=643&epage=654&aulast=Markovchick&aufirst=Vincent+J.&auinit=V.J.&aufull=Markovchick+V.J.&coden=EMCAD&isbn=&pages=643-654&date=2007&auinit1=V&auinitm=J
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 848
TITLE
  Prevention of respiratory complications of spinal cord injury: A challenge 
to "model" spinal cord injury units
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Department of Physical Medicine and Rehabilitation, University 
Hospital B-261, 150 Bergen Street, Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine and Rehabilitation, University 
Hospital B-261, 150 Bergen Street, Newark, NJ 07103, United States.
FULL RECORD ENTRY DATE
  2009-01-19
SOURCE
  Journal of Spinal Cord Medicine (2006) 29:1 (3-4). Date of Publication: 2006
VOLUME
  29
ISSUE
  1
FIRST PAGE
  3
LAST PAGE
  4
DATE OF PUBLICATION
  2006
ISSN
  1079-0268
BOOK PUBLISHER
  Maney Publishing, Suite 1C, Joseph's Well, Hanover Walk, Leeds, United 
Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory tract disease (complication, prevention, surgery, therapy); spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure (complication, prevention, surgery, therapy); amyotrophic lateral sclerosis; cannulation; clinical protocol; cost effectiveness analysis; coughing (therapy); Duchenne muscular dystrophy (therapy); editorial; expiratory flow; human; inspiratory capacity; intermittent positive pressure ventilation; invasive procedure; lung clearance; morbidity; muscle function; neuromuscular disease (therapy); neuromuscular system; non invasive procedure; patient safety; quadriplegia (surgery, therapy); respiratory tract infection (complication, prevention, therapy); respiratory tract intubation; speech; spinal muscular atrophy (therapy); suction; swallowing; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2008598101
MEDLINE PMID
  16572558 (http://www.ncbi.nlm.nih.gov/pubmed/16572558)
PUI
  L352830414
DOI
  10.1080/10790268.2006.11753847
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2006.11753847
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2006.11753847&atitle=Prevention+of+respiratory+complications+of+spinal+cord+injury%3A+A+challenge+to+%22model%22+spinal+cord+injury+units&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=29&issue=1&spage=3&epage=4&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=JSCMC&isbn=&pages=3-4&date=2006&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 849
TITLE
  Spinal cord gliomas and hydrocephalus: Utility of neuroendoscopy
AUTHOR NAMES
  Galarza M.; Peretta P.; Gazzeri R.; Cinalli G.; Forni M.; Morra I.; Ragazzi P.; Sandri S.
AUTHOR ADDRESSES
  (Galarza M., galarza.marcelo@gmail.com; Peretta P.; Cinalli G.; Ragazzi P.) 
Division of Neurosurgery, Children Hospital of Turin, Turin, Italy.
(Forni M.; Morra I.) Department of Pathology, Children Hospital of Turin, 
Turin, Italy.
(Sandri S.) Department of Oncology, Children Hospital of Turin, Turin, 
Italy.
(Gazzeri R.) Department of Neurosurgery, San Giovanni-Addolorata Hospital, 
Rome, Italy.
(Galarza M., galarza.marcelo@gmail.com) Division of Neurosurgery, Villa 
Maria Cecilia Hospital, 48010 Cotignola RA, Italy.
CORRESPONDENCE ADDRESS
  M. Galarza, Division of Neurosurgery, Villa Maria Cecilia Hospital, 48010 
Cotignola RA, Italy. Email: galarza.marcelo@gmail.com
FULL RECORD ENTRY DATE
  2007-04-01
SOURCE
  Minimally Invasive Neurosurgery (2006) 49:6 (347-352). Date of Publication: 
December 2006
VOLUME
  49
ISSUE
  6
FIRST PAGE
  347
LAST PAGE
  352
DATE OF PUBLICATION
  December 2006
ISSN
  0946-7211
BOOK PUBLISHER
  Georg Thieme Verlag, Rudigerstrasse 14, Stuttgart, Germany.
ABSTRACT
  Objective: The aim of this study is to report on the role of neuroendoscopy 
during the management of hydrocephalus that led to the diagnosis of 
intracranial tumoral dissemination and the subsequent finding of a spinal 
cord glioma. Methods and Results: We present two children each with an 
intramedullary astrocytoma that presented initially with hydrocephalus 
without spinal cord symptoms. In both cases leptomeningeal gliomatous 
dissemination was asserted during routine endoscopy for the management of 
hydrocephalus. The diagnosis of a cervical and a lower thoracic 
intramedullary tumor was made soon after on magnetic resonance imaging. 
Conclusions: Spinal cord MRI with contrast should be considered initially in 
selected cases of hydrocephalus without evident diagnosis. The 
intraoperative diagnosis of gliomatous dissemination and secondary 
hydrocephalus due to unrecognized spinal cord gliomas was possible, in our 
experience, with the routine use of the neuroendoscope. © Georg Thieme 
Verlag KG Stuttgart.
EMTREE DRUG INDEX TERMS
  antineoplastic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  astrocytoma (diagnosis, drug therapy, surgery); glioma (diagnosis, drug therapy, surgery); hydrocephalus; spinal cord tumor (diagnosis, drug therapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  anamnesis; article; brain biopsy; cancer chemotherapy; cancer grading; case report; cerebrospinal fluid examination; cervical spinal cord; clinical feature; controlled study; craniectomy; human; human tissue; immunohistochemistry; infant; leptomeninx; male; neuroendoscopy; neurologic examination; nuclear magnetic resonance imaging; preschool child; respiratory failure (complication, surgery); thoracic spinal cord; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Cancer (16)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007129435
MEDLINE PMID
  17323261 (http://www.ncbi.nlm.nih.gov/pubmed/17323261)
PUI
  L46396456
DOI
  10.1055/s-2006-955066
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-2006-955066
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09467211&id=doi:10.1055%2Fs-2006-955066&atitle=Spinal+cord+gliomas+and+hydrocephalus%3A+Utility+of+neuroendoscopy&stitle=Minimally+Invasive+Neurosurg.&title=Minimally+Invasive+Neurosurgery&volume=49&issue=6&spage=347&epage=352&aulast=Galarza&aufirst=Marcelo&auinit=M.&aufull=Galarza+M.&coden=MINUE&isbn=&pages=347-352&date=2006&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 850
TITLE
  Effusion of the hips in a patient with tetraplegia
AUTHOR NAMES
  Kupfer M.; Dholakia M.; O'Neill B.J.
AUTHOR ADDRESSES
  (Kupfer M., mxkupfer@gmail.com; Dholakia M.; O'Neill B.J.) Department of 
Rehabilitation Medicine, Thomas Jefferson University Hospital, Philadelphia, 
PA, United States.
(Kupfer M., mxkupfer@gmail.com) 25 South 9th Street, Philadelphia, PA 19107, 
United States.
CORRESPONDENCE ADDRESS
  M. Kupfer, 25 South 9th Street, Philadelphia, PA 19107, United States. 
Email: mxkupfer@gmail.com
FULL RECORD ENTRY DATE
  2009-01-19
SOURCE
  Journal of Spinal Cord Medicine (2006) 29:2 (160-162). Date of Publication: 
2006
VOLUME
  29
ISSUE
  2
FIRST PAGE
  160
LAST PAGE
  162
DATE OF PUBLICATION
  2006
ISSN
  1079-0268
BOOK PUBLISHER
  Maney Publishing, Suite 1C, Joseph's Well, Hanover Walk, Leeds, United 
Kingdom.
ABSTRACT
  Background: Patients with spinal cord injury are at risk for knee effusion, 
most likely as a result of repetitive microtrauma. Patients with paralysis 
are susceptible to effusions of the hip similar to those seen in documented 
cases regarding the knee. The etiology is likely similar and is related to 
repetitive microtrauma, such as that experienced when aggressive range of 
motion exercises are applied. Design: Case report. Setting: Acute 
rehabilitation department of a spinal cord injury center. Findings: A 
19-year-old man with a complete cervical spinal cord injury presented to 
acute rehabilitation on postinjury day 25 with a C6 American Spinal Injury 
Association classification A injury, complete. He was found to have 
bilateral hip effusions. Joint aspiration yielded a right sterile 
hydroarthrosis and a left sterile hemarthrosis. During his rehabilitation 
stay, the patient developed one mildly elevated alkaline phosphatase level, 
but he showed no radiographic evidence of heterotopic ossification and 
maintained full passive range of motion of the hips. Conclusion: This case 
indicates that hip effusion may be a similar, less-common occurrence than 
knee effusion in patients with spinal cord injury. In this case, bilateral 
aseptic hip effusion was not associated with heterotopic ossification. More 
research is needed to determine the etiology and sequelae of this condition.
EMTREE DRUG INDEX TERMS
  alkaline phosphatase (endogenous compound); enoxaparin (drug therapy, subcutaneous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  joint effusion (diagnosis); quadriplegia; 
EMTREE MEDICAL INDEX TERMS
  adult; alkaline phosphatase blood level; arthrodesis; article; bleeding; bone graft; case report; clinical feature; computer assisted tomography; deep vein thrombosis (drug therapy, prevention); epidural hemorrhage; human; joint aspiration; joint dislocation (diagnosis, surgery); lung embolism; male; nuclear magnetic resonance imaging; percutaneous endoscopic gastrostomy; rehabilitation care; respiratory failure (complication); soft tissue swelling; spinal cord hemorrhage (diagnosis); spinal hematoma; spine fracture (diagnosis); substance abuse; swelling; tracheotomy; 
CAS REGISTRY NUMBERS
  alkaline phosphatase (9001-78-9)
  enoxaparin (9041-08-1)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008598097
MEDLINE PMID
  16739560 (http://www.ncbi.nlm.nih.gov/pubmed/16739560)
PUI
  L352830410
DOI
  10.1080/10790268.2006.11753870
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2006.11753870
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2006.11753870&atitle=Effusion+of+the+hips+in+a+patient+with+tetraplegia&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=29&issue=2&spage=160&epage=162&aulast=Kupfer&aufirst=Mendel&auinit=M.&aufull=Kupfer+M.&coden=JSCMC&isbn=&pages=160-162&date=2006&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 851
TITLE
  Drug treatment for spinal muscular atrophy type I
AUTHOR NAMES
  Bosboom W.M.J.; Van Den Berg L.H.; Iannaccone S.T.; Vrancken A.F.J.E.; Wokke J.H.J.
AUTHOR ADDRESSES
  (Bosboom W.M.J., w.m.j.bosboom@umcutrecht.nl) Department of Child Neurology, 
University Medical Center Utrecht, Lundlaan 6, Utrecht 3508 AB, Netherlands.
(Van Den Berg L.H.; Iannaccone S.T.; Vrancken A.F.J.E.; Wokke J.H.J.)
CORRESPONDENCE ADDRESS
  W.M.J. Bosboom, Department of Child Neurology, University Medical Center 
Utrecht, Lundlaan 6, Utrecht 3508 AB, Netherlands. Email: 
w.m.j.bosboom@umcutrecht.nl
FULL RECORD ENTRY DATE
  2006-12-01
SOURCE
  Cochrane Database of Systematic Reviews (2006) :4 Article Number: CD006281. 
Date of Publication: 2006
ISSUE
  4
DATE OF PUBLICATION
  2006
ISSN
  1469-493X
BOOK PUBLISHER
  John Wiley and Sons Ltd, Southern Gate, Chichester, West Sussex, United 
Kingdom.
ABSTRACT
  This is the protocol for a review and there is no abstract. The objectives 
are as follows: To review systematically the evidence from randomised 
controlled trials concerning the efficacy and safety of any drug therapy 
designed to slow or arrest the progress of the disease in SMA type I. We 
will perform a separate Cochrane review on SMA type II and III. Copyright © 
2006 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; Werdnig Hoffmann disease; 
EMTREE MEDICAL INDEX TERMS
  air conditioning; child development; clinical trial; Cochrane Library; developmental screening; disease course; drug efficacy; drug safety; human; outcome assessment; review; sitting; standing; systematic review; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007265050
PUI
  L46841196
DOI
  10.1002/14651858.CD006281
FULL TEXT LINK
  http://dx.doi.org/10.1002/14651858.CD006281
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1469493X&id=doi:10.1002%2F14651858.CD006281&atitle=Drug+treatment+for+spinal+muscular+atrophy+type+I&stitle=Cochrane+Database+Syst.+Rev.&title=Cochrane+Database+of+Systematic+Reviews&volume=&issue=4&spage=&epage=&aulast=Bosboom&aufirst=Wendy+M.J.&auinit=W.M.J.&aufull=Bosboom+W.M.J.&coden=&isbn=&pages=-&date=2006&auinit1=W&auinitm=M.J.
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 852
TITLE
  Spinal muscular atrophy with respiratory disease (SMARD): An ethical dilemma
AUTHOR NAMES
  Bush A.
AUTHOR ADDRESSES
  (Bush A., a.bush@rbh.nthames.nhs.uk) Imperial School of Medicine, National 
Heart and Lung Institute, Department of Paediatric Respirology, London, 
United Kingdom.
(Bush A., a.bush@rbh.nthames.nhs.uk) Royal Brompton Hospital, Department of 
Paediatric Respiratory Medicine, Sydney Street, SW3 6NP London, United 
Kingdom.
CORRESPONDENCE ADDRESS
  A. Bush, Royal Brompton Hospital, Department of Paediatric Respiratory 
Medicine, Sydney Street, SW3 6NP London, United Kingdom. Email: 
a.bush@rbh.nthames.nhs.uk
FULL RECORD ENTRY DATE
  2006-11-21
SOURCE
  Intensive Care Medicine (2006) 32:11 (1691-1693). Date of Publication: 
November 2006
VOLUME
  32
ISSUE
  11
FIRST PAGE
  1691
LAST PAGE
  1693
DATE OF PUBLICATION
  November 2006
ISSN
  0342-4642
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory tract disease; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  clinical research; coughing; editorial; human; Internet; medical information; medical practice; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2006516519
MEDLINE PMID
  16964484 (http://www.ncbi.nlm.nih.gov/pubmed/16964484)
PUI
  L44607354
DOI
  10.1007/s00134-006-0347-7
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00134-006-0347-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03424642&id=doi:10.1007%2Fs00134-006-0347-7&atitle=Spinal+muscular+atrophy+with+respiratory+disease+%28SMARD%29%3A+An+ethical+dilemma&stitle=Intensive+Care+Med.&title=Intensive+Care+Medicine&volume=32&issue=11&spage=1691&epage=1693&aulast=Bush&aufirst=Andrew&auinit=A.&aufull=Bush+A.&coden=ICMED&isbn=&pages=1691-1693&date=2006&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 853
TITLE
  Airway management of a patient with Forestier's disease
AUTHOR NAMES
  Ozkalkanli M.Y.; Katircioglu K.; Ozkalkanli D.T.; Savaci S.
AUTHOR ADDRESSES
  (Ozkalkanli M.Y.; Katircioglu K.; Ozkalkanli D.T.; Savaci S.) Department of 
Anesthesiology and Reanimation, Izmir Ataturk Training And Research 
Hospital, Yesilyurt, Izmir, Turkey.
CORRESPONDENCE ADDRESS
  M.Y. Ozkalkanli, Department of Anesthesiology and Reanimation, Izmir Ataturk 
Training And Research Hospital, Yesilyurt, Izmir, Turkey.
FULL RECORD ENTRY DATE
  2006-11-27
SOURCE
  Journal of Anesthesia (2006) 20:4 (304-306). Date of Publication: November 
2006
VOLUME
  20
ISSUE
  4
FIRST PAGE
  304
LAST PAGE
  306
DATE OF PUBLICATION
  November 2006
ISSN
  0913-8668
BOOK PUBLISHER
  Springer-Verlag Tokyo, 3-13, Hongo 3-chome, Bunkyo-ku, Tokyo, Japan.
ABSTRACT
  Forestier's disease, also called diffuse idiopathic skeletal hyperostosis 
(DISH), is a noninflammatory enthesopathy, ossifying the anterolateral spine 
and sparing the disc and joint space in elderly men, mostly at thoracic 
levels. Intubation difficulty and spinal cord injury are potential problems 
when managing the airway in DISH patients. We report a patient with 
Forestier's disease who was admitted for osteophyte resection. After taking 
a detailed history, we evaluated the airway carefully. Also, preparation for 
difficult intubation was done. After a rapid sequence induction, we 
performed mask ventilation and laryngoscopy without hyperextension of the 
neck, to prevent spinal cord injury. Although the worldwide standard for 
management of the airway in DISH patients is awake fiberoptic intubation, we 
chose conventional laryngoscopy because a fiberoptic bronchoscope was not 
available. © JSA 2006.
EMTREE DRUG INDEX TERMS
  fentanyl (drug combination); flumazenil; midazolam (drug combination); naloxone; nitric oxide; oral antidiabetic agent (drug therapy, oral drug administration); propofol (drug combination); suxamethonium (drug combination); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing hyperostosis (surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; anesthesia induction; article; case report; coughing; diabetes mellitus (drug therapy); dysphagia; dysphonia; dyspnea; elective surgery; extubation; general anesthesia; hospital admission; human; intubation; laryngeal mask; laryngoscopy; male; operation duration; osteophyte; spinal cord injury (prevention); tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  flumazenil (78755-81-4)
  midazolam (59467-70-8)
  naloxone (357-08-4, 465-65-6)
  nitric oxide (10102-43-9)
  propofol (2078-54-8)
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006530883
MEDLINE PMID
  17072696 (http://www.ncbi.nlm.nih.gov/pubmed/17072696)
PUI
  L44650713
DOI
  10.1007/s00540-006-0418-5
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00540-006-0418-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09138668&id=doi:10.1007%2Fs00540-006-0418-5&atitle=Airway+management+of+a+patient+with+Forestier%27s+disease&stitle=J.+Anesth.&title=Journal+of+Anesthesia&volume=20&issue=4&spage=304&epage=306&aulast=Ozkalkanli&aufirst=Murat+Y.&auinit=M.Y.&aufull=Ozkalkanli+M.Y.&coden=JOANE&isbn=&pages=304-306&date=2006&auinit1=M&auinitm=Y
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 854
TITLE
  Study of the effectiveness of bronchial clearance in subjects with upper 
spinal cord injuries: Examination of a rehabilitation programme involving 
mechanical insufflation and exsufflation
AUTHOR NAMES
  Pillastrini P.; Bordini S.; Bazzocchi G.; Belloni G.; Menarini M.
AUTHOR ADDRESSES
  (Pillastrini P.) Department of Neurological Sciences, Rehabilitative 
Sciences - S.S.D. MED/48, University of Bologna, Bologna, Italy.
(Bordini S.; Belloni G.; Menarini M.) Spinal Cord Unit, Montecatone 
Rehabilitation Institute, Imola, Italy.
(Bazzocchi G.) Visceral Disorder Clinic, Montecatone Rehabilitation 
Institute, Imola, Italy.
(Bazzocchi G.) University of Bologna, Bologna, Italy.
(Pillastrini P.) Department of Neurological Sciences, Rehabilitative 
Sciences - S.S.D. MED/48, University of Bologna, Via U. Foscolo, 7, 40123 
Bologna, Italy.
CORRESPONDENCE ADDRESS
  P. Pillastrini, Department of Neurological Sciences, Rehabilitative Sciences 
- S.S.D. MED/48, University of Bologna, Via U. Foscolo, 7, 40123 Bologna, 
Italy.
FULL RECORD ENTRY DATE
  2006-11-21
SOURCE
  Spinal Cord (2006) 44:10 (614-616). Date of Publication: 13 Oct 2006
VOLUME
  44
ISSUE
  10
FIRST PAGE
  614
LAST PAGE
  616
DATE OF PUBLICATION
  13 Oct 2006
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Randomized controlled trial. Objectives: To establish whether 
the use of mechanical insufflation/exsufflation leads to a significant 
improve in tracheostomy subjects with upper spinal cord injuries (C1-C7), 
ASIA classification grade A and bronchial hyper secretion the following 
parameters: forced vital capacity (FVC), forced exspiratory volume on the 
first second (FEV1), FEV1/FVC, peak exspiratory flow (PEF), arterious 
pressure of O (2) (Pa O(2)), arterious pressure of CO(2) (Pa CO(2)), pH, 
saturation of O(2) (Sa O(2)). Setting: Spinal Cord Unit, Montecatone 
Rehabilitation Institute, Imola, Italy. Methods: The patients were split 
into two groups: the experimental group (EG) and the control group (CG). 
Each patient was given 10 treatments: the EG was given manual respiratory 
kinesitherapy associated with mechanical insufflation/ exsufflation with 
inhale and exhale pressure between 15 cm H(2)O and 45 cm H(2)O, while the CG 
was only given manual kinesitherapy. The treatment sessions covered the 
necessary amount of time in order to achieve sufficient clearance. The study 
has been approved by the local ethic committee. The patients were informed 
before being enrolled in that study and gave their written consent. Results: 
At the end of the treatment associated with the mechanical 
insufflation/exsufflation, the EG showed a significant increase in FVC, FEV1 
and PEF, although it was not possible to compare the latter with the CG. The 
other parameters were also subject to variations, although not statistically 
significant. The CG did not show signs of any significant change. 
Conclusion: The use of mechanical insufflation/exsufflation in subjects with 
the aforementioned characteristics is shown to be an effective adjunct to 
manual respiratory kinesitherapy, since it makes it possible to achieve 
adequate bronco-pulmonary clearance, even removing thick, deep secretions 
and making it possible to insufflate any areas affected by atelectasis. © 
2006 International Spinal Cord Society. All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury (rehabilitation, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; arterial carbon dioxide tension; arterial oxygen tension; arterial pH; article; atelectasis; bronchus secretion; clinical trial; controlled clinical trial; controlled study; exhalation; female; forced expiratory volume; human; inhalation; kinesiotherapy; male; oxygen saturation; peak expiratory flow; priority journal; randomized controlled trial; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006514350
MEDLINE PMID
  16344851 (http://www.ncbi.nlm.nih.gov/pubmed/16344851)
PUI
  L44600323
DOI
  10.1038/sj.sc.3101870
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3101870
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3101870&atitle=Study+of+the+effectiveness+of+bronchial+clearance+in+subjects+with+upper+spinal+cord+injuries%3A+Examination+of+a+rehabilitation+programme+involving+mechanical+insufflation+and+exsufflation&stitle=Spinal+Cord&title=Spinal+Cord&volume=44&issue=10&spage=614&epage=616&aulast=Pillastrini&aufirst=P.&auinit=P.&aufull=Pillastrini+P.&coden=SPCOF&isbn=&pages=614-616&date=2006&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 855
TITLE
  Cervical spine hyperostosis: An unusual cause of difficult intubation during 
coronary artery bypass grafting
AUTHOR NAMES
  Arora D.; Sharma K.K.; Mehta Y.; Chaudhury A.; Trehan N.
AUTHOR ADDRESSES
  (Arora D.; Sharma K.K.; Mehta Y.; Chaudhury A.; Trehan N.) Department of 
Cardiac Anesthesiology, Critical Care Escorts Heart Institute and Research 
Centre, New Delhi-110025, India.
CORRESPONDENCE ADDRESS
  Y. Mehta, Department of Cardiac Anesthesiology, Critical Care Escorts Heart 
Institute and Research Centre, New Delhi-110025, India.
FULL RECORD ENTRY DATE
  2007-12-05
SOURCE
  Journal of Anaesthesiology Clinical Pharmacology (2006) 22:4 (411-414). Date 
of Publication: October 2006
VOLUME
  22
ISSUE
  4
FIRST PAGE
  411
LAST PAGE
  414
DATE OF PUBLICATION
  October 2006
ISSN
  0970-9185
BOOK PUBLISHER
  Journal of Anaesthesiology Clinical Pharmacology, Dayanand Medical College 
and Hospital, Ludhiana, India.
EMTREE DRUG INDEX TERMS
  bupivacaine (drug therapy); fentanyl citrate; propofol; suxamethonium; thiopental; vecuronium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hyperostosis (diagnosis); osteophyte (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  akinesia (diagnosis); anamnesis; angiocardiography; article; cardiomegaly (complication, diagnosis); case report; cervical spine; clinical feature; computer assisted tomography; coronary artery bypass graft; echocardiography; endotracheal intubation; fiberoptic bronchoscopy; heart left ventricle ejection fraction; heart left ventricle hypertrophy; human; hyperventilation; hypokinesia (diagnosis); in-stent restenosis (diagnosis); intubation; laryngoscopy; lung blood vessel; lung function test; lung ventilation; male; minimally invasive cardiac surgery; physical examination; positive end expiratory pressure; postoperative pain (drug therapy); robotics; school child; skin incision; sternotomy; surgical technique; thorax radiography; trachea stenosis; trachea tumor; tracheostomy; 
CAS REGISTRY NUMBERS
  bupivacaine (18010-40-7, 2180-92-9, 55750-21-5)
  fentanyl citrate (990-73-8)
  propofol (2078-54-8)
  suxamethonium (306-40-1, 71-27-2)
  thiopental (71-73-8, 76-75-5)
  vecuronium (50700-72-6)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
  Arthritis and Rheumatism (31)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007565858
PUI
  L350143316
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09709185&id=doi:&atitle=Cervical+spine+hyperostosis%3A+An+unusual+cause+of+difficult+intubation+during+coronary+artery+bypass+grafting&stitle=J.+Anaesthesiol.+Clin.+Pharmacol.&title=Journal+of+Anaesthesiology+Clinical+Pharmacology&volume=22&issue=4&spage=411&epage=414&aulast=Arora&aufirst=Dheeraj&auinit=D.&aufull=Arora+D.&coden=JAPHF&isbn=&pages=411-414&date=2006&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 856
TITLE
  Neuromuscular disease in respiratory and critical care medicine
AUTHOR NAMES
  Hill N.S.
AUTHOR ADDRESSES
  (Hill N.S., nhill@tufts-nemc.org) Tufts University School of Medicine, 
Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts-New England 
Medical Center, Boston, MA, United States.
(Hill N.S., nhill@tufts-nemc.org) Division of Pulmonary, Critical Care, and 
Sleep Medicine, Tufts-New England Medical Center, 750 Washington Street, 
#257, Boston, MA 02111-1526, United States.
CORRESPONDENCE ADDRESS
  N.S. Hill, Division of Pulmonary, Critical Care, and Sleep Medicine, 
Tufts-New England Medical Center, 750 Washington Street, #257, Boston, MA 
02111-1526, United States. Email: nhill@tufts-nemc.org
FULL RECORD ENTRY DATE
  2007-01-02
SOURCE
  Respiratory Care (2006) 51:9 (1065-1071). Date of Publication: September 
2006
VOLUME
  51
ISSUE
  9
FIRST PAGE
  1065
LAST PAGE
  1071
DATE OF PUBLICATION
  September 2006
ISSN
  0020-1324
BOOK PUBLISHER
  Daedalus Enterprises Inc., 9425 North MacArthur Blvd, Suite 100, Irving, 
United States.
ABSTRACT
  Neuromuscular diseases that affect the respiratory system are a major cause 
of morbidity and mortality in both acute and long-term settings. This 
conference examined the pathophysiology and management of neuromuscular 
diseases in both settings. Presentations by experts representing 
respiratory, physiologic, pediatric, neurologic, and intensive-care 
disciplines covered a broad range of topics. This summary of the conference 
briefly describes the main points of each presentation and highlights areas 
that need addressing in the future. Major topics covered include the basic 
respiratory pathophysiology of neuromuscular disease; respiratory 
complications and management of amyotrophic lateral sclerosis; techniques of 
noninvasive ventilation and secretion removal; and evaluation and management 
of neuromuscular-induced respiratory failure in the acute-care setting, 
including Guillain-Barré syndrome, myasthenic crisis, and critical-illness 
myoneuropathy. © 2006 Daedalus Enterprises.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; neuromuscular disease; respiratory tract disease (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; artificial ventilation; bronchus secretion; clinical feature; conference paper; critical illness; diaphragm injury (complication); dyspnea (therapy); Guillain Barre syndrome; human; long term care; lung function; morbidity; mortality; motoneuron; myasthenia gravis; neuropathy; non invasive procedure; pathophysiology; spinal cord injury; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006597243
MEDLINE PMID
  16934169 (http://www.ncbi.nlm.nih.gov/pubmed/16934169)
PUI
  L44870540
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201324&id=doi:&atitle=Neuromuscular+disease+in+respiratory+and+critical+care+medicine&stitle=Respir.+Care&title=Respiratory+Care&volume=51&issue=9&spage=1065&epage=1071&aulast=Hill&aufirst=Nicholas+S.&auinit=N.S.&aufull=Hill+N.S.&coden=RECAC&isbn=&pages=1065-1071&date=2006&auinit1=N&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 857
TITLE
  Neurological and functional outcome after unstable cervicothoracic junction 
injury treated by posterior reduction and synthesis
AUTHOR NAMES
  Lenoir T.; Hoffmann E.; Thevenin-Lemoine C.; Lavelle G.; Rillardon L.; Guigui P.
AUTHOR ADDRESSES
  (Lenoir T., lenoirthibaut@yahoo.fr; Hoffmann E.; Thevenin-Lemoine C.; 
Lavelle G.; Rillardon L.; Guigui P.) Hôpital Beaujon, 100 Bvd Du General 
Leclerc, 92118 Clichy, France.
CORRESPONDENCE ADDRESS
  T. Lenoir, Hôpital Beaujon, 100 Bvd Du General Leclerc, 92118 Clichy, 
France. Email: lenoirthibaut@yahoo.fr
FULL RECORD ENTRY DATE
  2006-09-10
SOURCE
  Spine Journal (2006) 6:5 (507-513). Date of Publication: September/October 
2006
VOLUME
  6
ISSUE
  5
FIRST PAGE
  507
LAST PAGE
  513
DATE OF PUBLICATION
  September/October 2006
ISSN
  1529-9430
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  Background context: Unstable lesions of the cervicothoracic junction present 
a severe clinical problem for diagnosis, treatment, and prognosis. Purpose: 
The objective of the present study was to evaluate the neurological and 
functional outcomes following surgical treatments which combine in all cases 
posterior reduction and stabilization. Study design: Retrospective clinical 
and radiological study. Patient samples: Between September 1996 and 
September 2003, 30 patients underwent surgery for unstable fracture at the 
cervicothoracic junction. This group included 23 patients who sustained a 
motor vehicle accident, 5 who had fallen from a height, 1 case of ballistic 
trauma, and 1 person injured by diving in shallow water. There were 22 male 
and 8 female patients aged between 18 and 80, with an average age of 49. In 
18 cases the lesion level was vertebra C7, in 5 cases vertebra T1, in 2 
cases vertebra T2, and in 5 cases vertebra T3. Neurologically, on initial 
clinical examination 16 patients were classified Frankel A, 6 Frankel B, 2 
Frankel C, and 6 Frankel D. Surgically, all the patients underwent posterior 
reduction and synthesis. Posterior stabilization was performed using rods 
and screws 3 times, plate-screw fixation 25 times, and rods and screws at 
the thoracic level linked to plate-screw at the cervical level 2 times. 
Spinal cord compression of more than two levels was associated with 25 
cases. In these 25 cases, spinal cord decompression was associated with 
reduction and stabilization. Outcome measures: Clinical outcome using 
neurological scale of Frankel, radiological outcomes using computed 
tomographic (CT) scans and plain X-ray evaluations. Methods: Follow-up 
periods ranged from 11 to 48 months, with an average of 18 months. Seven 
patients died as a result of cardiopulmonary insufficiency within 4 months 
postoperative. Twenty-eight CT scans with sagittal and frontal slides were 
examined to evaluate postoperative reduction and to control screw placement. 
Results: The observed reductions were satisfactory in 27 cases. In one case, 
reduction was satisfactory in the sagittal plane but lateral translation 
persisted in the frontal plane. Two mechanical failures with delayed 
mobilization of implants occurred. Bony fusion was recorded in all cases on 
CT scan evaluation. Complete or partial neurological recovery was observed 
in only 10 of 14 patients. The initial neurological status of these 14 
patients was Frankel B, C, or D. Conclusion: The surgical procedure was 
chosen according to the particularity of the anatomical region and the 
possibility of associated medullar decompression. Insertion of pedicle 
screws in the upper thoracic portion in T1, T2, and T3 requires a careful 
technique and knowledge of the posterior projection points of the pedicles 
and their orientation in space. The high rate of fusion observed in these 
patients justified posterior reduction and stabilization. The high death 
rate and the low rate of neurological recovery in this group of patients 
emphasizes the severe prognosis of unstable injuries of the cervicothoracic 
junction. Considering the few mechanical failures observed at the last 
examination, the choice of the posterior approach was appropriate as the one 
stage procedure. Plate synthesis is preferable in fractures that do not 
require extension of synthesis beyond T2, whereas screws and rods systems 
are more appropriate for superior thoracic injuries. Despite early diagnosis 
and surgical treatment, the presence of neurological or pulmonary lesions 
resulted in increased mortality of the operated patients. © 2006 Elsevier 
Inc. All rights reserved.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture (surgery); neurologic disease (complication); spine injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; biomechanics; bone screw; cardiopulmonary insufficiency (complication); cervical spine radiography; clinical article; computer assisted tomography; controlled study; death; disease severity; dysphagia (complication, surgery); falling; female; follow up; fracture fixation; functional status; gunshot injury; human; lung infection (complication); lung injury (complication); male; mortality; postoperative infection (complication, drug therapy); postoperative period; priority journal; prognosis; prosthesis complication (complication); retrospective study; spinal cord compression (surgery); spinal cord decompression; spine fusion; spine stabilization; surgical technique; tracheotomy; traffic accident; treatment outcome; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006395863
MEDLINE PMID
  16934719 (http://www.ncbi.nlm.nih.gov/pubmed/16934719)
PUI
  L44242064
DOI
  10.1016/j.spinee.2005.12.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.spinee.2005.12.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15299430&id=doi:10.1016%2Fj.spinee.2005.12.010&atitle=Neurological+and+functional+outcome+after+unstable+cervicothoracic+junction+injury+treated+by+posterior+reduction+and+synthesis&stitle=Spine+J.&title=Spine+Journal&volume=6&issue=5&spage=507&epage=513&aulast=Lenoir&aufirst=Thibaut&auinit=T.&aufull=Lenoir+T.&coden=SJPOA&isbn=&pages=507-513&date=2006&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 858
TITLE
  Percutaneous tracheostomy in patients with cervical spine fractures - 
Feasible and safe
AUTHOR NAMES
  Nun A.B.; Orlovsky M.; Best L.A.
AUTHOR ADDRESSES
  (Nun A.B., a_ben_nun@rambam.health.gov.il; Orlovsky M.; Best L.A.) 
Department of General Thoracic Surgery, Rambam Medical Center, Haifa, 31096, 
Israel.
CORRESPONDENCE ADDRESS
  A.B. Nun, Department of General Thoracic Surgery, Rambam Medical Center, 
Haifa, 31096, Israel. Email: a_ben_nun@rambam.health.gov.il
FULL RECORD ENTRY DATE
  2006-08-13
SOURCE
  Interactive Cardiovascular and Thoracic Surgery (2006) 5:4 (427-429). Date 
of Publication: 1 Aug 2006
VOLUME
  5
ISSUE
  4
FIRST PAGE
  427
LAST PAGE
  429
DATE OF PUBLICATION
  1 Aug 2006
ISSN
  1569-9293
  1569-9293 (electronic)
ABSTRACT
  The aim of this study is to evaluate the short and long-term results of 
percutaneous tracheostomy in patients with documented cervical spine 
fracture. Between June 2000 and September 2005, 38 consecutive percutaneous 
tracheostomy procedures were performed on multi-trauma patients with 
cervical spine fracture. Modified Griggs technique was employed at the 
bedside in the general intensive care department. Staff thoracic surgeons 
and anesthesiologists performed all procedures. Demographics, anatomical 
conditions, presence of co-morbidities and complication rates were recorded. 
The average operative time was 10 min (6-15). Two patients had minor 
complications. One patients had minor bleeding (50 cc) and one had mild 
cellulitis. Nine patients had severe paraparesis or paraplegia prior to the 
PCT procedure and 29 were without neurological damage. There was no PCT 
related neurological deterioration. Twenty-eight patients were discharged 
from the hospital, 21 were decannulated. The average follow-up period was 18 
months (1-48). There was no delayed, procedure related, complication. These 
results demonstrate that percutaneous tracheostomy is feasible and safe in 
patients with cervical spine fracture with minimal short and long-term 
morbidity. We believe that percutaneous tracheostomy is the procedure of 
choice for patients with cervical spine fracture who need prolonged 
ventilatory support.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; anesthesist; article; assisted ventilation; bleeding (complication); cellulitis (complication); cervical spine; clinical article; comorbidity; controlled study; demography; feasibility study; female; follow up; hospital discharge; human; intensive care unit; long term care; male; neurologic disease (complication); operation duration; paraplegia (complication); priority journal; risk assessment; thorax surgery; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006372062
PUI
  L44166449
DOI
  10.1510/icvts.2005.125690
FULL TEXT LINK
  http://dx.doi.org/10.1510/icvts.2005.125690
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15699293&id=doi:10.1510%2Ficvts.2005.125690&atitle=Percutaneous+tracheostomy+in+patients+with+cervical+spine+fractures+-+Feasible+and+safe&stitle=Interact.+Cardiovasc.+Thorac.+Surg.&title=Interactive+Cardiovascular+and+Thoracic+Surgery&volume=5&issue=4&spage=427&epage=429&aulast=Nun&aufirst=Alon+Ben&auinit=A.B.&aufull=Nun+A.B.&coden=ICTSC&isbn=&pages=427-429&date=2006&auinit1=A&auinitm=B
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 859
TITLE
  Respiratory dysfunction and management in spinal cord injury
AUTHOR NAMES
  Brown R.; DiMarco A.F.; Hoit J.D.; Garshick E.
AUTHOR ADDRESSES
  (Brown R., rbrown5@partners.org) Pulmonary and Critical Care Unit, 
Department of Medicine, Massachusetts General Hospital, Boston, MA, United 
States.
(Brown R., rbrown5@partners.org; Garshick E.) Harvard Medical School, 
Boston, MA, United States.
(DiMarco A.F.) Rammelkamp Research Center, MetroHealth Medical Center, 
Cleveland, OH, United States.
(DiMarco A.F.) Department of Physiology and Biophysics, Case Western Reserve 
University, Cleveland, OH, United States.
(Hoit J.D.) Department of Speech, Language, and Hearing Sciences, University 
of Arizona, Tucson, AZ, United States.
(Garshick E.) Pulmonary and Critical Care Medicine Section, Medical Service, 
Veterans Affairs Boston Healthcare System, Boston, MA, United States.
(Garshick E.) Channing Laboratory, Department of Medicine, Brigham and 
Women's Hospital, Boston, MA, United States.
(Brown R., rbrown5@partners.org) Pulmonary and Critical Care Unit, Bulfinch 
148, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, 
United States.
CORRESPONDENCE ADDRESS
  R. Brown, Pulmonary and Critical Care Unit, Bulfinch 148, Massachusetts 
General Hospital, 55 Fruit Street, Boston, MA 02114, United States. Email: 
rbrown5@partners.org
FULL RECORD ENTRY DATE
  2006-08-01
SOURCE
  Respiratory Care (2006) 51:8 (853-868). Date of Publication: August 2006
VOLUME
  51
ISSUE
  8
FIRST PAGE
  853
LAST PAGE
  868
DATE OF PUBLICATION
  August 2006
ISSN
  0020-1324
BOOK PUBLISHER
  Daedalus Enterprises Inc., 9425 North MacArthur Blvd, Suite 100, Irving, 
United States.
ABSTRACT
  Respiratory dysfunction is a major cause of morbidity and mortality in 
spinal cord injury (SCI), which causes impairment of respiratory muscles, 
reduced vital capacity, ineffective cough, reduction in lung and chest wall 
compliance, and excess oxygen cost of breathing due to distortion of the 
respiratory system. Severely affected individuals may require assisted 
ventilation, which can cause problems with speech production. Appropriate 
candidates can sometimes be liberated from mechanical ventilation by 
phrenic-nerve pacing and pacing of the external intercostal muscles. Partial 
recovery of respiratory-muscle performance occurs spontaneously. The 
eventual vital capacity depends on the extent of spontaneous recovery, years 
since injury, smoking, a history of chest injury or surgery, and maximum 
inspiratory pressure. Also, respiratory-muscle training and abdominal 
binders improve performance of the respiratory muscles. For patients on 
long-term ventilation, speech production is difficult. Often, practitioners 
are reluctant to deflate the tracheostomy tube cuff to allow speech 
production. Yet cuff-deflation can be done safely. Standard ventilator 
settings produce poor speech quality. Recent studies demonstrated vast 
improvement with long inspiratory time and positive end-expiratory pressure. 
Abdominal binders improve speech quality in patients with phrenic-nerve 
pacers. Recent data show that the level and completeness of injury and older 
age at the time of injury may not be related directly to mortality in SCI, 
which suggests that the care of SCI has improved. The data indicate that 
independent predictors of all-cause mortality include diabetes mellitus, 
heart disease, cigarette smoking, and percent-of-predicted forced expiratory 
volume in the first second. An important clinical problem in SCI is weak 
cough, which causes retention of secretions during infections. Methods for 
secretion clearance include chest physical therapy, spontaneous cough, 
suctioning, cough assistance by forced compression of the abdomen ("quad 
cough"), and mechanical insufflation-exsufflation. Recently described but 
not yet available for general use is activation of the abdominal muscles via 
an epidural electrode placed at spinal cord level T9-L1. © 2006 Daedalus 
Enterprises.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure (complication, therapy); spinal cord injury (epidemiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; assisted ventilation; breathing muscle; bronchoscopy; cigarette smoking; conference paper; diabetes mellitus; disease association; dyspnea; forced expiratory volume; human; laparoscopy; lung compliance; lung function; mechanoreceptor; morbidity; mortality; phrenic nerve; positive end expiratory pressure; smoking cessation; thorax injury; vital capacity; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007470291
MEDLINE PMID
  16867197 (http://www.ncbi.nlm.nih.gov/pubmed/16867197)
PUI
  L47471690
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201324&id=doi:&atitle=Respiratory+dysfunction+and+management+in+spinal+cord+injury&stitle=Respir.+Care&title=Respiratory+Care&volume=51&issue=8&spage=853&epage=868&aulast=Brown&aufirst=Robert&auinit=R.&aufull=Brown+R.&coden=RECAC&isbn=&pages=853-868&date=2006&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 860
TITLE
  Pediatric acute spinal cord injury
ORIGINAL (NON-ENGLISH) TITLE
  Lesión medular aguda en edad pediátrica
AUTHOR NAMES
  Claret Teruel G.; Trenchs Sáinz De La Maza V.; Palomeque Rico A.
AUTHOR ADDRESSES
  (Claret Teruel G., gclaret@hsjdhcn.org; Trenchs Sáinz De La Maza V.; 
Palomeque Rico A.) Unidad de Cuidados Intensivos, Unidad Integrada Hospital 
Sant Joan de Déu-Clinic, Universidad de Barcelona, Spain.
(Claret Teruel G., gclaret@hsjdhcn.org) P. Verdaguer, 106, 08700 Igualada, 
Barcelona, Spain.
CORRESPONDENCE ADDRESS
  G. Claret Teruel, P. Verdaguer, 106, 08700 Igualada, Barcelona, Spain. 
Email: gclaret@hsjdhcn.org
FULL RECORD ENTRY DATE
  2006-10-01
SOURCE
  Anales de Pediatria (2006) 65:2 (162-165). Date of Publication: August 2006
VOLUME
  65
ISSUE
  2
FIRST PAGE
  162
LAST PAGE
  165
DATE OF PUBLICATION
  August 2006
ISSN
  1695-4033
BOOK PUBLISHER
  Ediciones Doyma, S.L., Travesera de Gracia 17-21, Barcelona, Spain.
ABSTRACT
  Introduction: Pediatric acute spinal cord injury is rare but is often 
associated with significant disability and prolonged stay in the intensive 
care unit (ICU). Objectives: The main objective of this study was to 
determine the epidemiology, initial clinical abnormalities, diagnostic 
studies, treatment and outcome of acute spinal cord injuries in a tertiary 
level pediatric hospital. A second objective was to analyze whether early 
tracheostomy allows earlier discharge of these patients. Patients and 
methods: A retrospective analysis of patients with acute spinal cord 
injuries admitted to our pediatric ICU since 1992 was performed. Results: We 
included 16 patients in the study, 12 of whom were boys (75 %). The patients 
were aged from birth to 19 years on admission to the ICU. The length of stay 
in the ICU was between 12 hours and 6 years. The cause of the lesion was 
birth trauma in four patients; one died and the remaining three live at home 
under mechanical ventilation. Traumatic injuries occurred in seven patients, 
two of whom died; a further two live in a long-term care facility and the 
remaining three live at home. Vascular spinal malformation occurred in two 
patients, and the three remaining injuries occurred during the acute 
postoperative period following spinal surgery. Of the 16 children, 56.2% 
were tracheostomized and 83% of the survivors live at home. Conclusions: 
Early tracheostomy, the availability of invasive ventilation for home use 
and parent education permit earlier discharge of these patients and allow 
more of them to live at home.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; artificial ventilation; birth injury; child; clinical article; clinical feature; controlled study; diagnostic procedure; female; hospital admission; hospital discharge; hospitalization; human; infant; intensive care unit; long term care; male; newborn; overall survival; postoperative period; spine malformation; spine surgery; tertiary health care; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  English, Spanish
EMBASE ACCESSION NUMBER
  2006457973
MEDLINE PMID
  16948980 (http://www.ncbi.nlm.nih.gov/pubmed/16948980)
PUI
  L44407453
DOI
  10.1157/13091487
FULL TEXT LINK
  http://dx.doi.org/10.1157/13091487
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=16954033&id=doi:10.1157%2F13091487&atitle=Pediatric+acute+spinal+cord+injury&stitle=An.+Pediatr.&title=Anales+de+Pediatria&volume=65&issue=2&spage=162&epage=165&aulast=Claret+Teruel&aufirst=G.&auinit=G.&aufull=Claret+Teruel+G.&coden=APNEC&isbn=&pages=162-165&date=2006&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 861
TITLE
  Discussion
AUTHOR NAMES
  Jubran; Benditt; Hill; Brown; Lechtzin; Upinder Dhand
AUTHOR ADDRESSES
  (Jubran; Benditt; Hill; Brown; Lechtzin; Upinder Dhand)
FULL RECORD ENTRY DATE
  2006-08-01
SOURCE
  Respiratory Care (2006) 51:8 (869-870). Date of Publication: August 2006
VOLUME
  51
ISSUE
  8
FIRST PAGE
  869
LAST PAGE
  870
DATE OF PUBLICATION
  August 2006
ISSN
  0020-1324
BOOK PUBLISHER
  Daedalus Enterprises Inc., 9425 North MacArthur Blvd, Suite 100, Irving, 
United States.
EMTREE DRUG INDEX TERMS
  carbon dioxide; glucose; lipid (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory care; spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis (therapy); atherosclerosis (complication); carbon dioxide tension; cardiovascular disease (complication, therapy); chronic respiratory failure (complication, therapy); conference paper; Duchenne muscular dystrophy (therapy); exercise; glucose tolerance test; human; lipid blood level; mortality; positive end expiratory pressure; tracheostomy; ventilator; 
CAS REGISTRY NUMBERS
  carbon dioxide (124-38-9, 58561-67-4)
  glucose (50-99-7, 84778-64-3)
  lipid (66455-18-3)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Human Genetics (22)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007470292
PUI
  L47471691
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201324&id=doi:&atitle=Discussion&stitle=Respir.+Care&title=Respiratory+Care&volume=51&issue=8&spage=869&epage=870&aulast=Jubran&aufirst=&auinit=&aufull=Jubran&coden=RECAC&isbn=&pages=869-870&date=2006&auinit1=&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 862
TITLE
  Respiratory effects of amyotrophic lateral sclerosis: Problems and solutions
AUTHOR NAMES
  Lechtzin N.
AUTHOR ADDRESSES
  (Lechtzin N., nlechtz1@jhmi.ed) School of Medicine, Johns Hopkins 
University, Baltimore, MD, United States.
(Lechtzin N., nlechtz1@jhmi.ed) Division of Pulmonary and Critical Care 
Medicine, Department of Medicine, 1830 E Monument Street, Baltimore, MD 
21205, United States.
CORRESPONDENCE ADDRESS
  N. Lechtzin, Division of Pulmonary and Critical Care Medicine, Department of 
Medicine, 1830 E Monument Street, Baltimore, MD 21205, United States. Email: 
nlechtz1@jhmi.ed
FULL RECORD ENTRY DATE
  2006-08-01
SOURCE
  Respiratory Care (2006) 51:8 (871-881). Date of Publication: August 2006
VOLUME
  51
ISSUE
  8
FIRST PAGE
  871
LAST PAGE
  881
DATE OF PUBLICATION
  August 2006
ISSN
  0020-1324
BOOK PUBLISHER
  Daedalus Enterprises Inc., 9425 North MacArthur Blvd, Suite 100, Irving, 
United States.
ABSTRACT
  Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative 
disease. Most patients die from respiratory complications. Fortunately, 
there are a growing number of treatment options that can improve both 
survival and quality of life for patients with ALS. This review discusses 
the respiratory evaluation and treatment of patients with ALS, about which a 
great deal is known. It also includes material on related problems, such as 
speech and swallowing difficulties and end-of-life care. © 2006 Daedalus 
Enterprises.
EMTREE DRUG INDEX TERMS
  influenza vaccine; oxygen; Streptococcus vaccine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (therapy); respiratory function; spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; balloon catheter; carbon dioxide tension; conference paper; degenerative disease; esophagus; human; infection prevention; influenza vaccination; larynx spasm; lung function test; magnetic stimulation; muscle strength; nonhuman; physiotherapy; positive end expiratory pressure; quality of life; REM sleep; respiratory tract infection (complication, etiology, therapy); speech disorder; stomach tube; Streptococcus pneumoniae; total lung capacity; tracheostomy; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Immunology, Serology and Transplantation (26)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007470293
MEDLINE PMID
  16867198 (http://www.ncbi.nlm.nih.gov/pubmed/16867198)
PUI
  L47471692
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201324&id=doi:&atitle=Respiratory+effects+of+amyotrophic+lateral+sclerosis%3A+Problems+and+solutions&stitle=Respir.+Care&title=Respiratory+Care&volume=51&issue=8&spage=871&epage=881&aulast=Lechtzin&aufirst=Noah&auinit=N.&aufull=Lechtzin+N.&coden=RECAC&isbn=&pages=871-881&date=2006&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 863
TITLE
  Discussion
AUTHOR NAMES
  Pierson D.J.; Benditt; Hill; Lechtzin; Brown
AUTHOR ADDRESSES
  (Pierson D.J.) Division of Pulmonary and Critical Care Medicine, Harborview 
Medical Center, University of Washington, Seattle, WA, United States.
(Benditt; Hill; Lechtzin; Brown)
CORRESPONDENCE ADDRESS
  D.J. Pierson, Division of Pulmonary and Critical Care Medicine, Harborview 
Medical Center, University of Washington, Seattle, WA, United States.
FULL RECORD ENTRY DATE
  2006-08-01
SOURCE
  Respiratory Care (2006) 51:8 (922-924). Date of Publication: August 2006
VOLUME
  51
ISSUE
  8
FIRST PAGE
  922
LAST PAGE
  924
DATE OF PUBLICATION
  August 2006
ISSN
  0020-1324
BOOK PUBLISHER
  Daedalus Enterprises Inc., 9425 North MacArthur Blvd, Suite 100, Irving, 
United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care unit; neuromuscular disease (therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis (therapy); artificial ventilation; conference paper; coughing; Duchenne muscular dystrophy (therapy); face mask; human; lung edema; muscular dystrophy (therapy); respiratory care; spinal cord injury (therapy); tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007470300
PUI
  L47471699
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201324&id=doi:&atitle=Discussion&stitle=Respir.+Care&title=Respiratory+Care&volume=51&issue=8&spage=922&epage=924&aulast=Pierson&aufirst=David+J.&auinit=D.J.&aufull=Pierson+D.J.&coden=RECAC&isbn=&pages=922-924&date=2006&auinit1=D&auinitm=J
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 864
TITLE
  Spinal muscular atrophy type 1: What are the ethics and practicality of 
respiratory support?
AUTHOR NAMES
  Mitchell I.
AUTHOR ADDRESSES
  (Mitchell I., ian.mitchell@calgaryhealthregion.ca) University of Calgary, 
Canada.
CORRESPONDENCE ADDRESS
  I. Mitchell, University of Calgary, Canada. Email: 
ian.mitchell@calgaryhealthregion.ca
FULL RECORD ENTRY DATE
  2006-07-24
SOURCE
  Paediatric Respiratory Reviews (2006) 7:SUPPL. 1 (S210-S211). Date of 
Publication: 2006
VOLUME
  7
ISSUE
  SUPPL. 1
DATE OF PUBLICATION
  2006
ISSN
  1526-0542
  1526-0550 (electronic)
BOOK PUBLISHER
  W.B. Saunders Ltd, 32 Jamestown Road, London, United Kingdom.
ABSTRACT
  Spinal Muscular Atrophy Type I (SMA I) is the most severe form of SMA. It 
presents in infancy and without treatment death occurs by 2 years. 
Treatments in use address respiratory and nutritional issues but even with 
aggressive treatment death is still likely in childhood. Thus their use is 
not obligatory. However, pediatric respirologists must be willing and 
comfortable at presenting all treatment options, including the option of 
palliative care, to families and then supporting the family's choice. 
Whatever the chosen treatment regimen, decision making is difficult for 
families. Support and help must be provided from the time of presentation 
till death by a knowledgeable and compassionate team. © 2006 Elsevier Ltd. 
All rights reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; assisted ventilation; childhood; clinical protocol; death; disease severity; family; human; infancy; interpersonal communication; medical decision making; medical ethics; nutritional support; palliative therapy; priority journal; respiratory failure; respiratory tract disease; review; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006290809
MEDLINE PMID
  16798568 (http://www.ncbi.nlm.nih.gov/pubmed/16798568)
PUI
  L43906286
DOI
  10.1016/j.prrv.2006.04.200
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.prrv.2006.04.200
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=15260542&id=doi:10.1016%2Fj.prrv.2006.04.200&atitle=Spinal+muscular+atrophy+type+1%3A+What+are+the+ethics+and+practicality+of+respiratory+support%3F&stitle=Paediatr.+Respir.+Rev.&title=Paediatric+Respiratory+Reviews&volume=7&issue=SUPPL.+1&spage=&epage=&aulast=Mitchell&aufirst=Ian&auinit=I.&aufull=Mitchell+I.&coden=PRRAE&isbn=&pages=-&date=2006&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 865
TITLE
  Dynamic anterior cervical plates for multilevel anterior corpectomy and 
fusion with simultaneous posterior wiring and fusion: Efficacy and outcomes
AUTHOR NAMES
  Epstein N.E.
AUTHOR ADDRESSES
  (Epstein N.E.) Department of Neurological Surgery, Albert Einstein College 
of Medicine, Bronx, NY, United States.
(Epstein N.E.) Department of Neurosurgey, Winthrop University Hospital, 
Mineola, NY, United States.
(Epstein N.E.) Department of Neurosurgey, Long Island Neurosurgical 
Associates P.C., 410 Lakeville Rd, New Hyde Pk, NY 11042, United States.
CORRESPONDENCE ADDRESS
  N.E. Epstein, Department of Neurosurgey, Long Island Neurosurgical 
Associates P.C., 410 Lakeville Rd, New Hyde Pk, NY 11042, United States.
FULL RECORD ENTRY DATE
  2006-07-30
SOURCE
  Spinal Cord (2006) 44:7 (432-439). Date of Publication: 22 Jul 2006
VOLUME
  44
ISSUE
  7
FIRST PAGE
  432
LAST PAGE
  439
DATE OF PUBLICATION
  22 Jul 2006
ISSN
  1362-4393
  1476-5624 (electronic)
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: To prospectively evaluate major complications associated with 
the application of dynamic ABC plates (Aesculap, Tuttlingen, Germany) to 
multilevel Anterior Corpectomy/Fusion (ACF) followed by posterior fusion 
(C2-C7 PF). Objectives: To determine whether dynamic ABC (Aesculap, 
Tuttlingen, Germany) plates would minimize major complications (plate/graft 
extrusion, pseudarthrosis) while maximizing neurological outcomes in 40 
consecutive patients undergoing simultaneous multilevel ACF/PF with halo 
application. Setting: USA. Methods: Patients averaged 53 years of age and 
preoperatively exhibited severe myeloradiculopathy (Nurick Grade 3.9). MR/CT 
studies documented marked ossification of the posterior longitudinal 
ligament/spondylostenosis. Surgery included two to four level ACF utilizing 
fibula strut allograft and ABC plates. Posterior spinous process 
wiring/fusions utilized braided titanium cables. The average operative time 
was 8.9 h. Fusion was confirmed on dynamic X-rays/CTs (3-12 months 
postoperatively). The average follow-up interval was 2.7 years. Outcomes (3 
months-2 years postoperatively) were assessed utilizing Odom's Criteria, 
Nurick Grades, and SF-36 questionnaires. Results: Major complications 
included one pseudarthrosis requiring secondary PWF. Minor complications in 
six patients included two pulmonary emboli (PE), two tracheostomies, and 
five superficial wound infections. At 1 year postoperatively, marked 
improvement was observed in all patients utilizing Odom's criteria (38 
excellent/good), Nurick Grades (mild radiculopathy 0.4), and the SF-36 (3 
Health Scales; Role Physical (12.5-38.6), Bodily Pain (39.9-65.5), and Role 
Emotional (53.8-75.8)]. The 2-year postoperative data showed minimal 
additional improvement. The average time to fusion was 6.3 months. 
Conclusion: Patients undergoing multilevel ACF/PF demonstrated marked 
neurological improvement (SF-36), and only one of 40 developed a delayed 
pseudarthrosis. © 2006 International Spinal Cord Society All rights 
reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spine fusion; multilevel anterior corpectomy and fusion; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; bone graft; bone plate; clinical article; devices; female; follow up; human; lung embolism (diagnosis); male; myeloradiculopathy (diagnosis); neurological complication; outcomes research; priority journal; pseudarthrosis (diagnosis); tracheostomy; wound infection; 
DEVICE TRADE NAMES
  ABC  , GermanyAesculap Meditec

DEVICE MANUFACTURERS
   (Germany)Aesculap Meditec
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006325130
MEDLINE PMID
  16317424 (http://www.ncbi.nlm.nih.gov/pubmed/16317424)
PUI
  L44015139
DOI
  10.1038/sj.sc.3101874
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3101874
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3101874&atitle=Dynamic+anterior+cervical+plates+for+multilevel+anterior+corpectomy+and+fusion+with+simultaneous+posterior+wiring+and+fusion%3A+Efficacy+and+outcomes&stitle=Spinal+Cord&title=Spinal+Cord&volume=44&issue=7&spage=432&epage=439&aulast=Epstein&aufirst=N.E.&auinit=N.E.&aufull=Epstein+N.E.&coden=SPCOF&isbn=&pages=432-439&date=2006&auinit1=N&auinitm=E
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 866
TITLE
  Molecular mechanism of rigid spine with muscular dystrophy type 1 caused by 
novel mutations of selenoprotein N gene
AUTHOR NAMES
  Okamoto Y.; Takashima H.; Higuchi I.; Matsuyama W.; Suehara M.; Nishihira Y.; Hashiguchi A.; Hirano R.; Ng A.R.; Nakagawa M.; Izumo S.; Osame M.; Arimura K.
AUTHOR ADDRESSES
  (Okamoto Y.; Takashima H., thiroshi@m3.kufm.kagoshima-u.ac.jp; Higuchi I.; 
Matsuyama W.; Hashiguchi A.; Hirano R.; Ng A.R.; Osame M.; Arimura K.) 
Department of Neurology and Geriatrics, Kagoshima University, Graduate 
School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City, 
Kagoshima 890-8520, Japan.
(Okamoto Y.; Izumo S.) Department of Molecular Pathology, Center for Chronic 
Vial Disease, Kagoshima University School of Medicine, Kagoshima, Japan.
(Suehara M.; Nishihira Y.) Department of Neurology, Okinawa Hospital, 
Okinawa, Japan.
(Nakagawa M.) Department of Neurology and Gerontology, Kyoto Prefectural 
University of Medicine, Kyoto, Japan.
CORRESPONDENCE ADDRESS
  H. Takashima, Department of Neurology and Geriatrics, Kagoshima University, 
Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 
Kagoshima City, Kagoshima 890-8520, Japan. Email: 
thiroshi@m3.kufm.kagoshima-u.ac.jp
FULL RECORD ENTRY DATE
  2006-07-30
SOURCE
  Neurogenetics (2006) 7:3 (175-183). Date of Publication: July 2006
VOLUME
  7
ISSUE
  3
FIRST PAGE
  175
LAST PAGE
  183
DATE OF PUBLICATION
  July 2006
ISSN
  1364-6745
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Mutations of selenoprotein N, 1 gene (SEPN1) cause rigid spine with muscular 
dystrophy type 1 (RSMD1), multiminicore disease, and desmin-related 
myopathy. We found two novel SEPN1 mutations in two Japanese patients with 
RSMD1. To clarify the pathomechanism of RSMD1, we performed 
immunohistochemical studies using a newly developed antibody for 
selenoprotein N. Selenoprotein N was diffusely distributed in the cytoplasm 
of the control muscle, but was reduced and irregularly expressed in the 
cytoplasm of a patient with RSMD1. The expression pattern was very similar 
to that of calnexin, a transmembrane protein of the endoplasmic reticulum. 
Selenoprotein N seems to be an endoplasmic reticulum glycoprotein, and loss 
of this protein leads to disturbance of muscular function. One of the 
families had the SEPN1 homozygous mutation in the initiation codon 1_2 ins T 
in exon 1 and showed truncated protein expression. The other had a 
homozygous 20-base duplication mutation at 80 (80_99dup, frameshift at R27) 
which, in theory, should generate many nonsense mutations including TGA. 
These nonsense mutations are premature translation termination codons and 
they degrade immediately by the process of nonsense-mediated decay (NMD). 
However, truncated selenoprotein N was also expressed. A possible mechanism 
behind this observation is that SEPN1 mRNAs may be resistant to NMD. We 
report on the possible molecular mechanism behind these mutations in SEPN1. 
Our study clarifies molecular mechanisms of this muscular disorder. © 
Springer-Verlag 2006.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  selenoprotein (endogenous compound); selenoprotein n (endogenous compound); 
EMTREE DRUG INDEX TERMS
  calnexin (endogenous compound); glycoprotein (endogenous compound); membrane protein (endogenous compound); unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  gene mutation; muscular dystrophy (diagnosis, etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; antibody response; article; artificial ventilation; case report; clinical feature; codon; cytoplasm; disease classification; electrocardiography; electromyography; endoplasmic reticulum; exon; female; function test; gene expression; homozygosity; human; human tissue; immunohistochemistry; Japan; male; multigene family; muscle biopsy; muscle function; mutational analysis; nonsense mutation; pathophysiology; pneumonia; priority journal; protein depletion; protein expression; protein family; protein function; respiratory failure (complication, diagnosis, surgery, therapy); rigidity; spine; thorax radiography; tracheotomy; ventilator; 
CAS REGISTRY NUMBERS
  calnexin (139873-08-8)
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006343399
MEDLINE PMID
  16779558 (http://www.ncbi.nlm.nih.gov/pubmed/16779558)
PUI
  L44078295
DOI
  10.1007/s10048-006-0046-0
FULL TEXT LINK
  http://dx.doi.org/10.1007/s10048-006-0046-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13646745&id=doi:10.1007%2Fs10048-006-0046-0&atitle=Molecular+mechanism+of+rigid+spine+with+muscular+dystrophy+type+1+caused+by+novel+mutations+of+selenoprotein+N+gene&stitle=Neurogenetics&title=Neurogenetics&volume=7&issue=3&spage=175&epage=183&aulast=Okamoto&aufirst=Yuji&auinit=Y.&aufull=Okamoto+Y.&coden=NEROF&isbn=&pages=175-183&date=2006&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 867
TITLE
  Cervicomedullary Compression and Occipitocervical Instability
AUTHOR NAMES
  Kaiser M.G.; Haid R.W.
AUTHOR ADDRESSES
  (Kaiser M.G., mgk7@columbia.edu) Department of Neurosurgery, Columbia 
University, The Neurological Institute, 710 West 168th Street, Room 504, New 
York, NY 10032, United States.
(Haid R.W.) Atlanta Brain and Spine Care, 2001 Peachtree Road, NE, Suite 
645, Atlanta, GA 30309, United States.
CORRESPONDENCE ADDRESS
  M.G. Kaiser, Department of Neurosurgery, Columbia University, The 
Neurological Institute, 710 West 168th Street, Room 504, New York, NY 10032, 
United States. Email: mgk7@columbia.edu
FULL RECORD ENTRY DATE
  2006-08-21
SOURCE
  Neurosurgery Clinics of North America (2006) 17:3 (235-246). Date of 
Publication: July 2006
  Complication Avoidamce in Complex Spine Surgery, Book Series Title:
VOLUME
  17
ISSUE
  3
FIRST PAGE
  235
LAST PAGE
  246
DATE OF PUBLICATION
  July 2006
ISSN
  1042-3680
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Decompression of the cervicomedullary junction and stabilization from the 
occiput to the cervical spine pose significant challenges for a spine 
surgeon. Unrecognized progression of these disorders may result in permanent 
neurologic deficits and increase the complexity of surgical intervention. 
Careful attention to detail, including preoperative planning and surgical 
technique, are required to ensure success. Specific complications should be 
anticipated and preventive measures incorporated into the surgical plan. The 
consequences of these complications are dramatic, compromising the surgeon's 
ability to achieve the operative goals and leading to devastating clinical 
outcomes. Careful attention to detail decreases the incidence of these 
complications, however, and provides the surgeon with an effective 
management strategy to cope with these complications. © 2006 Elsevier Inc. 
All rights reserved.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy, pharmacology); bone cement; bone morphogenetic protein (endogenous compound); cephalosporin (drug therapy, pharmacology); contrast medium; hydrocortisone (drug therapy, topical drug administration); penicillin G (drug therapy, pharmacology); steroid (drug therapy, intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atlantooccipital joint; joint instability (diagnosis, surgery); spinal cord compression (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adrenoleukodystrophy (diagnosis); air embolism (complication); amyotrophic lateral sclerosis (diagnosis); angiography; blood vessel injury (complication); bone plate; bone screw; brain stem; cerebrospinal fluid; clinical feature; computer assisted tomography; cranial nerve injury (complication); devices; differential diagnosis; dura mater; dysphagia (complication); endotracheal tube; extubation; fluoroscopy; human; hypoglossal nerve; hypoglossal nerve disease (complication); intensive care unit; multiple sclerosis (diagnosis); neurologic disease (complication); neurosyphilis (diagnosis); nuclear magnetic resonance imaging; nutrition; occipital bone; patient education; pharyngitis (complication, drug therapy); postoperative infection (complication, drug therapy, prevention); priority journal; pseudarthrosis (complication); radiography; review; spinal cord decompression; spinal cord surgery; stomach tube; surgical technique; T lymphocyte; tongue swelling (complication, drug therapy); tracheostomy; treatment planning; vertebral artery; vertebral canal; wound dehiscence (complication); X ray; X ray film; 
CAS REGISTRY NUMBERS
  cephalosporin (11111-12-9)
  hydrocortisone (50-23-7)
  penicillin G (1406-05-9, 61-33-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2006349410
MEDLINE PMID
  16876025 (http://www.ncbi.nlm.nih.gov/pubmed/16876025)
PUI
  L44094114
DOI
  10.1016/j.nec.2006.04.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.nec.2006.04.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10423680&id=doi:10.1016%2Fj.nec.2006.04.010&atitle=Cervicomedullary+Compression+and+Occipitocervical+Instability&stitle=Neurosurg.+Clin.+North+Am.&title=Neurosurgery+Clinics+of+North+America&volume=17&issue=3&spage=235&epage=246&aulast=Kaiser&aufirst=Michael+G.&auinit=M.G.&aufull=Kaiser+M.G.&coden=NCNAF&isbn=&pages=235-246&date=2006&auinit1=M&auinitm=G
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 868
TITLE
  Airway management in adults after cervical spine trauma
AUTHOR NAMES
  Crosby E.T.
AUTHOR ADDRESSES
  (Crosby E.T., ecrosby@sympatico.ca) Department of Anesthesiology, Ottawa 
Hospital-General Campus, 501 Smyth Road, Ottawa, Ont. K1H 8L6, Canada.
CORRESPONDENCE ADDRESS
  E.T. Crosby, Department of Anesthesiology, Ottawa Hospital-General Campus, 
501 Smyth Road, Ottawa, Ont. K1H 8L6, Canada. Email: ecrosby@sympatico.ca
FULL RECORD ENTRY DATE
  2006-07-23
SOURCE
  Anesthesiology (2006) 104:6 (1293-1318). Date of Publication: June 2006
VOLUME
  104
ISSUE
  6
FIRST PAGE
  1293
LAST PAGE
  1318
DATE OF PUBLICATION
  June 2006
ISSN
  0003-3022
  1528-1175 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Cervical spinal injury occurs in 2% of victims of blunt trauma; the 
incidence is increased if the Glasgow Coma Scale score is less than 8 or if 
there is a focal neurologic deficit. Immobilization of the spine after 
trauma is advocated as a standard of care. A three-view x-ray series 
supplemented with computed tomography imaging is an effective imaging 
strategy to rule out cervical spinal injury. Secondary neurologic injury 
occurs in 2-10% of patients after cervical spinal injury; it seems to be an 
inevitable consequence of the primary injury in a subpopulation of patients. 
All airway interventions cause spinal movement; immobilization may have a 
modest effect in limiting spinal movement during airway maneuvers. Many 
anesthesiologists state a preference for the fiberoptic bronchoscope to 
facilitate airway management, although there is considerable, favorable 
experience with the direct laryngoscope in cervical spinal injury patients. 
There are no outcome data that would support a recommendation for a 
particular practice option for airway management; a number of options seem 
appropriate and acceptable. © 2006 American Society of Anesthesiologists, 
Inc. Lippincott Williams & Wilkins, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing disorder (therapy); cervical spine injury (diagnosis, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  airway; anesthesist; arterial insufficiency; assisted ventilation; atlantoaxial joint; atlantooccipital joint; biomechanics; blunt trauma; central cord syndrome; cervical spine; clinical practice; computer assisted tomography; endotracheal intubation; fiberoptic bronchoscopy; Glasgow coma scale; hospital admission; human; immobilization; intubation; laryngeal mask; laryngoscopy; ligament injury; medical practice; neurologic disease; nuclear magnetic resonance imaging; orthosis; outcome assessment; priority journal; resuscitation; review; spinal cord; spinal cord injury; spine instability; spine mobility; spine radiography; spine stabilization; tracheotomy; vein thrombosis; vertebral canal; X ray; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006273956
MEDLINE PMID
  16732102 (http://www.ncbi.nlm.nih.gov/pubmed/16732102)
PUI
  L43852964
DOI
  10.1097/00000542-200606000-00026
FULL TEXT LINK
  http://dx.doi.org/10.1097/00000542-200606000-00026
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00033022&id=doi:10.1097%2F00000542-200606000-00026&atitle=Airway+management+in+adults+after+cervical+spine+trauma&stitle=Anesthesiology&title=Anesthesiology&volume=104&issue=6&spage=1293&epage=1318&aulast=Crosby&aufirst=Edward+T.&auinit=E.T.&aufull=Crosby+E.T.&coden=ANESA&isbn=&pages=1293-1318&date=2006&auinit1=E&auinitm=T
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 869
TITLE
  Post-radiation intramedullary malignant peripheral nerve sheath tumor
AUTHOR NAMES
  Paolini S.; Raco A.; Di Stefano D.; Esposito V.; Ciappetta P.
AUTHOR ADDRESSES
  (Paolini S., spao2@yahoo.com) Division of Neurosurgery, IRCCS Neuromed. 
Pozzilli, Uiversity of Perugia, Italy.
(Raco A.; Esposito V.) Division of Neurosurgery, University La Sapienza, 
Rome, Italy.
(Di Stefano D.) Division of Pathology, University La Sapienza, Rome, Italy.
(Ciappetta P.) Division of Neurosurgery, University of Bari, Italy.
(Paolini S., spao2@yahoo.com) Via G. Verdi 52, 03430 Cassino (TR), Italy.
CORRESPONDENCE ADDRESS
  S. Paolini, Via G. Verdi 52, 03430 Cassino (TR), Italy. Email: 
spao2@yahoo.com
FULL RECORD ENTRY DATE
  2006-10-31
SOURCE
  Journal of Neurosurgical Sciences (2006) 50:2 (49-53). Date of Publication: 
June 2006
VOLUME
  50
ISSUE
  2
FIRST PAGE
  49
LAST PAGE
  53
DATE OF PUBLICATION
  June 2006
ISSN
  0026-4881
BOOK PUBLISHER
  Edizioni Minerva Medica S.p.A., Corso Bramante 83-85, Torino, Italy.
ABSTRACT
  We report the intramedullary growth of a malignant peripheral nerve sheath 
tumour (MPNST). A 50-year-old man developed a severe tetraparesis over a 
4-month period. Following irradiation of a chronic tonsillitis during his 
childhood, the patient had later experienced a number of post-radiation 
diseases, including a laryngeal cancer that required permanent tracheotomy. 
Before admission, a magnetic resonance imaging (MRI) study had disclosed a 
C4-C5 intramedullary lesion. On admission to our Department, the patient had 
a nearly complete tetraparesis. At surgery, the lesion was exposed through a 
posterior midline myelotomy. A friable neoplasm, with no clear plane of 
cleavage, was found. The tumour was subtotally resected. Histological 
examination, which intraoperatively had not yielded a specific diagnosis, 
eventually revealed a MPNST, grade intermediate, with ultrastructural and 
immunohistochemical features consistent with a schwannian differentiation. 
No postoperative radiotherapy was undertaken. The patient died 9 months 
later from pneumonial complications. MPNSTs may develop within the spinal 
cord similarly to their benign schwannian counterpart. The reported sequence 
of events might support a possible relation between irradiation of the 
spinal cord and induction, followed by malignant transformation, of 
intramedullary schwannosis. This unique case must be added to the growing 
list of radiation-induced spinal cord tumours.
EMTREE DRUG INDEX TERMS
  gadolinium; protein S 100 (endogenous compound); vimentin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  malignant neoplasm (diagnosis, surgery); nerve sheath tumor (diagnosis, surgery); peripheral nerve tumor (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; article; case report; cell differentiation; clinical feature; cordotomy; death; disease severity; histopathology; hospital admission; human; human cell; human tissue; immunohistochemistry; immunoreactivity; irradiation; male; neurologic examination; nuclear magnetic resonance imaging; postoperative care; quadriplegia; Schwann cell; 
CAS REGISTRY NUMBERS
  gadolinium (7440-54-2)
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006487574
MEDLINE PMID
  16841028 (http://www.ncbi.nlm.nih.gov/pubmed/16841028)
PUI
  L44504153
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00264881&id=doi:&atitle=Post-radiation+intramedullary+malignant+peripheral+nerve+sheath+tumor&stitle=J.+Neurosurg.+Sci.&title=Journal+of+Neurosurgical+Sciences&volume=50&issue=2&spage=49&epage=53&aulast=Paolini&aufirst=S.&auinit=S.&aufull=Paolini+S.&coden=JNSSB&isbn=&pages=49-53&date=2006&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 870
TITLE
  Control of an ACC-1-producing Klebsiella pneumoniae outbreak in a physical 
medicine and rehabilitation unit
AUTHOR NAMES
  Ohana S.; Denys P.; Guillemot D.; Lortat-Jacob S.; Ronco E.; Rottman M.; Bussel B.; Gaillard J.-L.; Lawrence C.
AUTHOR ADDRESSES
  (Ohana S.; Ronco E.; Rottman M.; Gaillard J.-L.; Lawrence C., 
christine.lawrence@rpc.aphp.fr) Laboratoire de microbiologie, Hôpital 
Raymond Poincaré, Assistance Publique - Hôpitaux de Paris, Garches, France.
(Denys P.; Lortat-Jacob S.; Bussel B.) Département de médecine physique et 
réadaptation, Hôpital Raymond Poincaré, Assistance Publique - Hôpitaux de 
Paris, Garches, France.
(Guillemot D.) CeRBEP, Institut Pasteur/U657, INSERM, Paris, France.
CORRESPONDENCE ADDRESS
  C. Lawrence, Laboratoire de microbiologie, Hôpital Raymond Poincaré, 
Assistance Publique - Hôpitaux de Paris, Garches, France. Email: 
christine.lawrence@rpc.aphp.fr
FULL RECORD ENTRY DATE
  2006-05-22
SOURCE
  Journal of Hospital Infection (2006) 63:1 (34-38). Date of Publication: May 
2006
VOLUME
  63
ISSUE
  1
FIRST PAGE
  34
LAST PAGE
  38
DATE OF PUBLICATION
  May 2006
ISSN
  0195-6701
BOOK PUBLISHER
  W.B. Saunders Ltd, 32 Jamestown Road, London, United Kingdom.
ABSTRACT
  This article describes an outbreak of ACC-1-producing Klebsiella pneumoniae 
involving 40 patients. These were mainly men under 40 years old with a 
spinal cord injury, in a physical medicine and rehabilitation unit. The main 
risk factors were prolonged hospital stay, multiple-bed rooms, tracheostomy 
care and assisted defaecation. The outbreak was only controlled after the 
introduction of rigorous patient placement (i.e. single rooms or cohorting 
in the same room), while allowing the patients to have free access to the 
various technical services (e.g. physiotherapy and occupational therapy) and 
living spaces necessary for re-education. © 2005 The Hospital Infection 
Society.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Enterobacteriaceae infection (complication, diagnosis, epidemiology, 
etiology, prevention, therapy); Klebsiella pneumoniae; physical medicine; rehabilitation medicine; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; asymptomatic bacteriuria (complication, diagnosis, epidemiology, etiology, 
prevention, therapy); bacterium isolation; clinical article; controlled study; defecation; disinfection; epidemic; female; hand washing; health care access; hospital bed capacity; hospital department; hospitalization; human; infection control; length of stay; male; occupational therapy; patient care; patient education; physiotherapy; pyelonephritis (complication, diagnosis, epidemiology, etiology, prevention, 
therapy); risk factor; spinal cord injury (rehabilitation, therapy); statistical analysis; tracheostomy; urinary tract infection (complication, diagnosis, epidemiology, etiology, 
prevention, therapy); 
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Urology and Nephrology (28)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006183362
MEDLINE PMID
  16519958 (http://www.ncbi.nlm.nih.gov/pubmed/16519958)
PUI
  L43585562
DOI
  10.1016/j.jhin.2005.11.010
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jhin.2005.11.010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01956701&id=doi:10.1016%2Fj.jhin.2005.11.010&atitle=Control+of+an+ACC-1-producing+Klebsiella+pneumoniae+outbreak+in+a+physical+medicine+and+rehabilitation+unit&stitle=J.+Hosp.+Infect.&title=Journal+of+Hospital+Infection&volume=63&issue=1&spage=34&epage=38&aulast=Ohana&aufirst=S.&auinit=S.&aufull=Ohana+S.&coden=JHIND&isbn=&pages=34-38&date=2006&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 871
TITLE
  Unanticipated difficult endotracheal intubations in patients with cervical 
spine instrumentation
AUTHOR NAMES
  Schoenhage K.O.; Koenig H.M.
AUTHOR ADDRESSES
  (Schoenhage K.O.) Department of Anesthesiology, University of Illinois, 
Chicago, IL, United States.
(Koenig H.M., heidi.koenig@louisville.edu) Department of Anesthesiology and 
Perioperative Medicine, University of Louisville, Louisville, KY, United 
States.
(Koenig H.M., heidi.koenig@louisville.edu) Department of Anesthesiology and 
Perioperative Medicine, University of Louisville, 530 South Jackson St., 
Louisville, KY 40202, United States.
CORRESPONDENCE ADDRESS
  H.M. Koenig, Department of Anesthesiology and Perioperative Medicine, 
University of Louisville, 530 South Jackson St., Louisville, KY 40202, 
United States. Email: heidi.koenig@louisville.edu
FULL RECORD ENTRY DATE
  2006-03-15
SOURCE
  Anesthesia and Analgesia (2006) 102:3 (960-963). Date of Publication: March 
2006
VOLUME
  102
ISSUE
  3
FIRST PAGE
  960
LAST PAGE
  963
DATE OF PUBLICATION
  March 2006
ISSN
  0003-2999
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  We present two cases of unanticipated difficult airway in patients requiring 
reoperation after cervical spine instrumentation. In both cases, the upper 
airway examination was normal, and fiberoptic-guided intubation proceeded 
with the patient sedated and breathing spontaneously. Cord visualization was 
difficult, but the scope was eventually advanced into the trachea and the 
endotracheal tube placed safely. Later review of radiographs showed the 
previously unrecognized protrusion of cervical hardware into the meso- and 
hypopharynx. We recommend that anesthesiologists review recent radiographic 
studies for potential airway compromise before approaching the airway of 
patients presenting for revision of cervical instrumentation. ©2006 by the 
International Anesthesia Research Society.
EMTREE DRUG INDEX TERMS
  benzocaine; cetacaine (topical drug administration); lidocaine (topical drug administration); midazolam; propofol; remifentanil; tetracaine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; endotracheal intubation; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; airway obstruction; anesthesist; article; case report; devices; discectomy; female; fiber optics; general anesthesia; human; hypopharynx; job performance; male; neurologic examination; priority journal; procedures; radiculopathy; reoperation; sedation; spine fusion; tracheostomy; 
CAS REGISTRY NUMBERS
  benzocaine (1333-08-0, 94-09-7)
  cetacaine (64082-67-3)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  propofol (2078-54-8)
  remifentanil (132539-07-2)
  tetracaine (136-47-0, 94-24-6)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006101388
MEDLINE PMID
  16492859 (http://www.ncbi.nlm.nih.gov/pubmed/16492859)
PUI
  L43306428
DOI
  10.1213/01.ane.0000194446.18696.eb
FULL TEXT LINK
  http://dx.doi.org/10.1213/01.ane.0000194446.18696.eb
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032999&id=doi:10.1213%2F01.ane.0000194446.18696.eb&atitle=Unanticipated+difficult+endotracheal+intubations+in+patients+with+cervical+spine+instrumentation&stitle=Anesth.+Analg.&title=Anesthesia+and+Analgesia&volume=102&issue=3&spage=960&epage=963&aulast=Schoenhage&aufirst=Kai+O.&auinit=K.O.&aufull=Schoenhage+K.O.&coden=AACRA&isbn=&pages=960-963&date=2006&auinit1=K&auinitm=O
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 872
TITLE
  Potential cervical spine injury and difficult airway management for 
emergency intubation of trauma adults in the emergency department - A 
systematic review
AUTHOR NAMES
  Ollerton J.E.; Parr M.J.A.; Harrison K.; Hanrahan B.; Sugrue M.
AUTHOR ADDRESSES
  (Ollerton J.E., j.ollerton@doctors.org.uk) Department of Trauma, Liverpool 
Hospital, Locked Bag 7103, Liverpool, NSW 1871, Australia.
(Parr M.J.A.; Harrison K.; Hanrahan B.; Sugrue M.) Liverpool Hospital, 
Locked Bag 7103, Liverpool, NSW 1871, Australia.
CORRESPONDENCE ADDRESS
  J.E. Ollerton, Department of Trauma, Liverpool Hospital, Locked Bag 7103, 
Liverpool, NSW 1871, Australia. Email: j.ollerton@doctors.org.uk
FULL RECORD ENTRY DATE
  2006-01-20
SOURCE
  Emergency Medicine Journal (2006) 23:1 (3-11). Date of Publication: January 
2006
VOLUME
  23
ISSUE
  1
FIRST PAGE
  3
LAST PAGE
  11
DATE OF PUBLICATION
  January 2006
ISSN
  1472-0205
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  Background: Emergency airway management for trauma adults is practised by 
physicians from a range of training backgrounds and with differing levels of 
experience. The indications for intubation and technique employed are 
factors that vary within EDs and between hospitals. Objectives: To provide 
practical evidence based guidance for airway management in trauma 
resuscitation: first for the trauma adult with potential cervical spine 
injury and second the management when a difficult airway is encountered at 
intubation. Search strategy and methodology: Full literature search for 
relevant articles in Medline (1966-2003), EMBASE (1980-2003), and the 
Cochrane Central Register of Controlled Trials. Relevant articles relating 
to adults and written in English language were appraised. English language 
abstracts of foreign articles were included. Studies were critically 
appraised on a standardised data collection sheet to assess validity and 
quality of evidence. The level of evidence was allocated using the methods 
of the Australian National Health and Medical Research Council.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; emergency treatment; endotracheal intubation; 
EMTREE MEDICAL INDEX TERMS
  airway conductance; airway obstruction (therapy); algorithm; anesthesia induction; anesthesiological procedure; clinical trial; emergency ward; evidence based medicine; human; injury severity; intensive care; laryngeal mask; laryngoscopy; lung clearance; neuromuscular blocking; practice guideline; priority journal; resuscitation; review; staff training; systematic review; tracheotomy; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006018704
MEDLINE PMID
  16373795 (http://www.ncbi.nlm.nih.gov/pubmed/16373795)
PUI
  L43056354
DOI
  10.1136/emj.2004.020552
FULL TEXT LINK
  http://dx.doi.org/10.1136/emj.2004.020552
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14720205&id=doi:10.1136%2Femj.2004.020552&atitle=Potential+cervical+spine+injury+and+difficult+airway+management+for+emergency+intubation+of+trauma+adults+in+the+emergency+department+-+A+systematic+review&stitle=Emerg.+Med.+J.&title=Emergency+Medicine+Journal&volume=23&issue=1&spage=3&epage=11&aulast=Ollerton&aufirst=J.E.&auinit=J.E.&aufull=Ollerton+J.E.&coden=EMJMB&isbn=&pages=3-11&date=2006&auinit1=J&auinitm=E
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 873
TITLE
  Transarticular screw fixation in bilateral traumatic facet dislocation of 
C6-7 vertebral level: A case report
AUTHOR NAMES
  Er U.; Simsek S.; Yiǧitkanli K.; Bavbek M.
AUTHOR ADDRESSES
  (Er U., uygurer@gmail.com; Simsek S.; Yiǧitkanli K.; Bavbek M.) 2nd 
Neurosurgery Clinic, Ankara Dişkapi Training and Research Hospital, Dişkapi, 
Ankara, Turkey.
(Er U., uygurer@gmail.com) Söǧütözü Caddesi, 4. Sokak, No: 22/7, Ankara, 
Turkey.
CORRESPONDENCE ADDRESS
  U. Er, Söǧütözü Caddesi, 4. Sokak, No: 22/7, Ankara, Turkey. Email: 
uygurer@gmail.com
FULL RECORD ENTRY DATE
  2009-01-06
SOURCE
  Turkish Neurosurgery (2006) 16:1 (44-47). Date of Publication: 2006
VOLUME
  16
ISSUE
  1
FIRST PAGE
  44
LAST PAGE
  47
DATE OF PUBLICATION
  2006
ISSN
  1019-5149
BOOK PUBLISHER
  Turkish Neurosurgical Society
ABSTRACT
  Bilateral facet dislocations at subaxial levels in a flexion-distraction 
type trauma are three-column injuries. Early reduction of the locked facets 
and decompression is critical in preventing progressive secondary spinal 
cord injury. We present a case of traumatic bilateral facet dislocations 
treated with transarticular screw fixation. Transarticular screw insertion 
at the subaxial levels of the cervical spine can be performed safely and 
easily. The biomechanical strength is adequate.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine dislocation (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; arm weakness; article; assisted ventilation; bone allograft; bone screw; case report; cervical spine radiography; computer assisted tomography; discectomy; fatality; fracture fixation; general anesthesia; human; male; nuclear magnetic resonance imaging; open reduction (procedure); paraplegia; pneumonia (therapy); respiratory arrest; skin incision; spine fusion; spine stabilization; tracheostomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, Turkish
EMBASE ACCESSION NUMBER
  2008580015
PUI
  L352785086
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10195149&id=doi:&atitle=Transarticular+screw+fixation+in+bilateral+traumatic+facet+dislocation+of+C6-7+vertebral+level%3A+A+case+report&stitle=Turk.+Neurosurg.&title=Turkish+Neurosurgery&volume=16&issue=1&spage=44&epage=47&aulast=Er&aufirst=Uygur&auinit=U.&aufull=Er+U.&coden=TUNEE&isbn=&pages=44-47&date=2006&auinit1=U&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 874
TITLE
  Onychomadesis in a child with spinal muscular atrophy type I
AUTHOR NAMES
  Ruggiero G.
AUTHOR ADDRESSES
  (Ruggiero G.)
(Ruggiero G.) Via C. Battisti, 44, 84091 Battipaglia (SA), Italy.
CORRESPONDENCE ADDRESS
  G. Ruggiero, Via C. Battisti, 44, 84091 Battipaglia (SA), Italy.
FULL RECORD ENTRY DATE
  2006-12-14
SOURCE
  European Journal of Pediatric Dermatology (2006) 16:3 (137-140). Date of 
Publication: 2006
VOLUME
  16
ISSUE
  3
FIRST PAGE
  137
LAST PAGE
  140
DATE OF PUBLICATION
  2006
ISSN
  1122-7672
BOOK PUBLISHER
  Dermatologia Pediatrica
ABSTRACT
  A case of Werdnig-Hoffmann disease or spinal muscular atrophy in a 
4-year-old child is reported. At this age the child presented onychomadesis 
of both halluces leading to the elimination of the distal fractured nail 
lamina within 8 months. Initially, a possible damage on the matrix induced 
by the saturimeter was hypothesized and led to move the latter from the 
halluces to the plantar region. However, onychomadesis relapsed on the right 
hallux a year after the suspension of contact with the saturimeter, ruling 
out this hypothesis. After having excluded infectious and traumatic causes, 
an idiopathic form possibly associated to spinal muscular atrophy was 
diagnosed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  nail dystrophy (diagnosis); onychomadesis (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  article; case report; hallux; hospitalization; human; intensive care unit; laboratory test; percutaneous endoscopic gastrostomy; preschool child; pyoderma; respiratory distress; spinal muscular atrophy; tracheotomy; Werdnig Hoffmann disease; 
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006595105
PUI
  L44862482
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11227672&id=doi:&atitle=Onychomadesis+in+a+child+with+spinal+muscular+atrophy+type+I&stitle=Eur.+J.+Pediatr.+Dermatol.&title=European+Journal+of+Pediatric+Dermatology&volume=16&issue=3&spage=137&epage=140&aulast=Ruggiero&aufirst=G.&auinit=G.&aufull=Ruggiero+G.&coden=EPDDE&isbn=&pages=137-140&date=2006&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 875
TITLE
  Delayed return of spontaneous respiration after cervical spinal cord injury. 
Case report
ORIGINAL (NON-ENGLISH) TITLE
  Późny powrót wydolnego oddechu u chorego po urazie rdzenia kregowego w 
odcinku szyjnym kregosłupa - Opis przypadku
AUTHOR NAMES
  Zeliaś A.
AUTHOR ADDRESSES
  (Zeliaś A., zelias@mp.pl) Oddział Anestezjologii i Intensywnej Terapii, WSS 
im. L. Rydygiera, Os. Złotej Jesieni 1, 31-826 Kraków, Poland.
CORRESPONDENCE ADDRESS
  A. Zeliaś, Oddział Anestezjologii i Intensywnej Terapii, WSS im. L. 
Rydygiera, Os. Złotej Jesieni 1, 31-826 Kraków, Poland. Email: zelias@mp.pl
FULL RECORD ENTRY DATE
  2006-03-06
SOURCE
  Anestezjologia Intensywna Terapia (2005) 37:4 (255-258). Date of 
Publication: 2005
VOLUME
  37
ISSUE
  4
FIRST PAGE
  255
LAST PAGE
  258
DATE OF PUBLICATION
  2005
ISSN
  0209-1712
ABSTRACT
  Background. High cervical spinal injury has been associated with 
irreversible respiratory muscle paralysis requiring long-term ventilation. 
We describe a case of a car accident victim in whom spontaneous respiration 
returned one year after the injury. Case report. An 18 yr-old man was 
transferred to the ICU after a car accident and cardiac arrest. Initial 
examination revealed C2, C3 and C4 fractures with C2 dislocation resulting 
in quadriparesis and spinal shock. After initial resuscitation, he underwent 
surgical decompression at the C3-C4 level, reposition of the dislocated 
vertebrae and occipitocervical fusion. Immediately after surgery, he 
required controlled ventilation because of complete paralysis of the 
diaphragm and other respiratory muscles. Gradually, activity of the neck 
muscles returned, allowing short periods (1-2 hours) of spontaneous 
ventilation, after 5 months. 14 months after injury, the function of the 
right diaphragm returned and it was possible to wean the patient from the 
ventilator. He breathed spontaneously via a tracheotomy, with a tidal volume 
of 500 ml and vital capacity of 1200 ml. Discussion and conclusion. The 
outcome described in this case is rare. In most patients with high cervical 
injury, long-term home ventilation or implantation of phrenic nerve 
stimulators remain the only therapeutic possibilities. A sudden increase in 
tidal volume may indicate the return of diaphragm function and therefore 
should be checked regularly.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing; cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; atlantooccipital joint; case report; cervical spine dislocation; cervical spine fracture; decompression surgery; diaphragm; heart arrest; home care; human; intensive care unit; long term care; male; muscle function; nerve stimulation; patient monitoring; phrenic nerve; physical examination; postoperative care; quadriplegia (complication); resuscitation; shock (complication); spine fusion; tidal volume; tracheotomy; traffic accident; ventilator; vital capacity; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Polish
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006093088
PUI
  L43280205
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02091712&id=doi:&atitle=Delayed+return+of+spontaneous+respiration+after+cervical+spinal+cord+injury.+Case+report&stitle=Anest.+Intens.+Ter.&title=Anestezjologia+Intensywna+Terapia&volume=37&issue=4&spage=255&epage=258&aulast=Zelia%C5%9B&aufirst=Aleksander&auinit=A.&aufull=Zelia%C5%9B+A.&coden=AITED&isbn=&pages=255-258&date=2005&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 876
TITLE
  Respiratory management following spinal cord injury: A clinical practice 
guideline for health-care professionals
AUTHOR ADDRESSES
  FULL RECORD ENTRY DATE
  2006-02-07
SOURCE
  Journal of Spinal Cord Medicine (2005) 28:3 (259-293). Date of Publication: 
2005
VOLUME
  28
ISSUE
  3
FIRST PAGE
  259
LAST PAGE
  293
DATE OF PUBLICATION
  2005
ISSN
  1079-0268
BOOK PUBLISHER
  American Paraplegia Society, 75-20 Astoria Boulevard, Jackson Heights, 
United States.
EMTREE DRUG INDEX TERMS
  anabolic agent (drug therapy); antibiotic agent (drug therapy); bicarbonate (drug therapy, inhalational drug administration); bronchodilating agent (drug therapy); cromoglycate disodium (drug therapy); methylxanthine (drug therapy); mucolytic agent (drug therapy); steroid (drug therapy); vaccine (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiration control; spinal cord injury (etiology); 
EMTREE MEDICAL INDEX TERMS
  arterial gas; aspiration; atelectasis (diagnosis, drug therapy, prevention, therapy); carbon dioxide tension; clinical practice; dysphagia; forced expiratory volume; human; lung receptor; lung ventilation; medical decision making; oxygen saturation; pneumonia (diagnosis, drug therapy, prevention, therapy); positive end expiratory pressure; practice guideline; review; risk assessment; sleep disordered breathing; spirometry; tidal volume; tracheostomy; vital capacity; 
CAS REGISTRY NUMBERS
  bicarbonate (144-55-8, 71-52-3)
  cromoglycate disodium (15826-37-6, 16110-51-3, 93356-79-7, 93356-84-4)
  methylxanthine (28109-92-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2006036994
MEDLINE PMID
  16048145 (http://www.ncbi.nlm.nih.gov/pubmed/16048145)
PUI
  L43108139
DOI
  10.1080/10790268.2005.11753821
FULL TEXT LINK
  http://dx.doi.org/10.1080/10790268.2005.11753821
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:10.1080%2F10790268.2005.11753821&atitle=Respiratory+management+following+spinal+cord+injury%3A+A+clinical+practice+guideline+for+health-care+professionals&stitle=J.+Spinal+Cord+Med.&title=Journal+of+Spinal+Cord+Medicine&volume=28&issue=3&spage=259&epage=293&aulast=&aufirst=&auinit=&aufull=&coden=JSCMC&isbn=&pages=259-293&date=2005&auinit1=&auinitm=
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 877
TITLE
  Respiratory complications and mortality risk associated with thoracic spine 
injury
AUTHOR NAMES
  Cotton B.A.; Pryor J.P.; Chinwalla I.; Wiebe D.J.; Reilly P.M.; Schwab C.W.; Brundage S.; Duane T.M.; Yelon J.
AUTHOR ADDRESSES
  (Cotton B.A., bryan.cotton@vanderbilt.edu; Pryor J.P.; Reilly P.M.; Schwab 
C.W.) Department of Surgery, Division of Traumatology and Surgical Critical 
Care, University of Pennsylvania, Philadelphia, PA, United States.
(Chinwalla I.; Wiebe D.J.; Schwab C.W.) Firearm and Injury Center, 
University of Pennsylvania, Philadelphia, PA, United States.
(Wiebe D.J.) Department of Biostatistics and Epidemiology, University of 
Pennsylvania, Philadelphia, PA, United States.
(Cotton B.A., bryan.cotton@vanderbilt.edu) Vanderbilt University Medical 
Center, Division of Trauma and Surgical Critical Care, 243 MCS, 2100 Pierce 
Ave, Nashville, TN 37212-3755, United States.
(Brundage S.)
(Duane T.M.)
(Yelon J.)
(Cotton B.A., bryan.cotton@vanderbilt.edu)
CORRESPONDENCE ADDRESS
  B.A. Cotton, Vanderbilt University Medical Center, Division of Trauma and 
Surgical Critical Care, 243 MCS, 2100 Pierce Ave, Nashville, TN 37212-3755, 
United States. Email: bryan.cotton@vanderbilt.edu
FULL RECORD ENTRY DATE
  2006-05-21
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2005) 59:6 
(1400-1409). Date of Publication: December 2005
VOLUME
  59
ISSUE
  6
FIRST PAGE
  1400
LAST PAGE
  1409
DATE OF PUBLICATION
  December 2005
ISSN
  0022-5282
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background: Cervical spinal cord injury (SCI) has a well-established 
association with a high risk of respiratory complications. We sought to 
determine whether high-thoracic (HT) SCI was associated with a similar 
increased risk of respiratory complications and death. Methods: This was a 
retrospective cohort study of all adult patients with thoracolumbar injuries 
entered into the Pennsylvania Trauma System Foundation registry between 
January 1993 and December 2002. Records were reviewed for the documentation 
of respiratory complications (intubation, tracheostomy, bronchoscopy, 
pneumonia) and mortality. The data were then evaluated controlling for age, 
sex, Glasgow Coma Scale, and Injury Severity Score. Results: In all, 11,080 
patients met inclusion criteria: 4,258 patients had thoracic spine fractures 
and 6,226 patients had lumbar spine fractures, all without SCI; and 596 
patients had thoracic SCI (T1 to T6, 231; T7 to T12, 365). Respiratory 
complications occurred in 51.1% of patients with T1 to T6 SCI (versus 34.5% 
in T7 to T12 SCI and 27.5% in thoracic fractures). The need for intubation, 
the risk of pneumonia, and risk of death were significantly greater for 
patients with T1-to T6-level spinal cord injuries. Among patients with an 
Injury Severity Score less than 17 (n = 6427), the relative mortality risk 
was 26.7 times higher among those who developed respiratory complications 
(9.9% versus 0.4%). Conclusion: Compared with patients with low thoracic SCI 
or thoracolumbar fractures, patients with HT-SCI have an increased risk of 
pneumonia and death. Respiratory complications significantly increase the 
mortality risk in less severely injured patients. The current findings 
suggest that HT-SCI patients warrant intensive monitoring and aggressive 
pulmonary care and attention, similar to that given for patients with 
cervical SCI. Copyright © 2005 by Lippincott Williams & Wilkins, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory tract disease (complication, diagnosis); spine injury (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; bronchoscopy; cohort analysis; death; evaluation study; female; human; injury scale; major clinical study; male; medical documentation; mortality; pneumonia (complication); priority journal; register; respiratory tract intubation; retrospective study; risk assessment; risk factor; thoracolumbar spine; tracheostomy; United States; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006202855
MEDLINE PMID
  16394913 (http://www.ncbi.nlm.nih.gov/pubmed/16394913)
PUI
  L43639697
DOI
  10.1097/01.ta.0000196005.49422.e6
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ta.0000196005.49422.e6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:10.1097%2F01.ta.0000196005.49422.e6&atitle=Respiratory+complications+and+mortality+risk+associated+with+thoracic+spine+injury&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=59&issue=6&spage=1400&epage=1409&aulast=Cotton&aufirst=Bryan+A.&auinit=B.A.&aufull=Cotton+B.A.&coden=JOTRF&isbn=&pages=1400-1409&date=2005&auinit1=B&auinitm=A
COPYRIGHT
  Copyright 2010 Elsevier B.V., All rights reserved.

RECORD 878
TITLE
  Factors associated with dysphagia in individuals with high tetraplegia
AUTHOR NAMES
  Shem K.; Castillo K.; Naran B.
AUTHOR ADDRESSES
  (Shem K.) Santa Clara Valley Medical Center, Northern California Spinal Cord 
Injury Model System of Care, San Jose, CA, United States.
(Shem K.) Department of Physical Medicine and Rehabilitation, San Jose, CA, 
United States.
(Castillo K.; Naran B.) Santa Clara Valley Medical Center, Northern 
California Spinal Cord Injury Model System of Care, Department of Physical 
Medicine and Rehabilitation, San Jose, CA, United States.
CORRESPONDENCE ADDRESS
  K. Shem, Santa Clara Valley Medical Center, Northern California Spinal Cord 
Injury Model System of Care, San Jose, CA, United States.
FULL RECORD ENTRY DATE
  2005-10-31
SOURCE
  Topics in Spinal Cord Injury Rehabilitation (2005) 10:3 (8-18). Date of 
Publication: Dec 2005
VOLUME
  10
ISSUE
  3
FIRST PAGE
  8
LAST PAGE
  18
DATE OF PUBLICATION
  Dec 2005
ISSN
  1082-0744
ABSTRACT
  The aim of this study was to identify the factors associated with dysphagia 
in individuals with high tetraplegia. The Santa Clara Valley Medical Center 
(SCVMC) has a high tetraplegia program utilizing experienced Speech 
Pathologists in the early evaluation of dysphagia and in appropriate 
intervention in individuals with high tetraplegia. The factors associated 
with dysphagia were ASIA impairment level, intubation, mechanical 
ventilation, and pulmonary infections. The earlier individuals were admitted 
to SCVMC, the less likely they were to have pulmonary complications, which 
may be a result of early screening by the SCVMC Speech Pathology Department 
for dysphagia. © 2005 Thomas Land Publishers, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (complication, diagnosis, therapy); quadriplegia (rehabilitation); spinal cord injury (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; diet; disability; early diagnosis; hospital admission; human; intubation; lung infection; major clinical study; medical specialist; rehabilitation center; risk factor; speech pathologist; tracheostomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005464982
PUI
  L41454540
DOI
  10.1310/HW9N-E1ME-FK6G-00TK
FULL TEXT LINK
  http://dx.doi.org/10.1310/HW9N-E1ME-FK6G-00TK
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10820744&id=doi:10.1310%2FHW9N-E1ME-FK6G-00TK&atitle=Factors+associated+with+dysphagia+in+individuals+with+high+tetraplegia&stitle=Top.+Spinal+Cord+Inj.+Rehabil.&title=Topics+in+Spinal+Cord+Injury+Rehabilitation&volume=10&issue=3&spage=8&epage=18&aulast=Shem&aufirst=Kazuko&auinit=K.&aufull=Shem+K.&coden=TSIRF&isbn=&pages=8-18&date=2005&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 879
TITLE
  Chiari malformation and odontoid panus causing craniovertebral stenosis in a 
child with Crouzon's syndrome
AUTHOR NAMES
  Dickerman R.D.; Lefkowitz M.; Arinsburg S.A.; Schneider S.J.
AUTHOR ADDRESSES
  (Dickerman R.D., drrdd@yahoo.com) Denton Regional Medical Center, Plano 
Presbyterian Hospitals, Plano, TX, United States.
(Lefkowitz M.; Arinsburg S.A.; Schneider S.J.) Department of Neurosurgery, 
North Shore University-Long Island Jewish Medical Center, New Hyde Park, NY, 
United States.
(Dickerman R.D., drrdd@yahoo.com) Department of Neurosurgery, 3001 
Communications Pkwy, Plano, TX 75093, United States.
CORRESPONDENCE ADDRESS
  R.D. Dickerman, Department of Neurosurgery, 3001 Communications Pkwy, Plano, 
TX 75093, United States. Email: drrdd@yahoo.com
FULL RECORD ENTRY DATE
  2006-01-05
SOURCE
  Journal of Clinical Neuroscience (2005) 12:8 (964-967). Date of Publication: 
November 2005
VOLUME
  12
ISSUE
  8
FIRST PAGE
  964
LAST PAGE
  967
DATE OF PUBLICATION
  November 2005
ISSN
  0967-5868
BOOK PUBLISHER
  Churchill Livingstone, 1-3 Baxter's Place, Leith Walk, Edinburgh, United 
Kingdom.
ABSTRACT
  Crouzon's disease is a well-known disorder affecting multiple organ systems, 
specifically a craniofacial disorder with highly variable penetrance and 
severity of deformity. Crouzon's patients typically have anomalies of the 
skull base leading to gross distortion of the cranium and in some cases the 
cervicocranium. We present a 5-year-old girl with Crouzon's disease who 
suffered from an acquired Chiari I malformation after insertion of a 
ventriculoperitoneal shunt and a coexistent ventral odontoid panus. Both 
these lesions were causing cervicomedullary compression. The literature is 
controversial on the surgical management of anterior and posterior 
compression at the craniocervical junction. We review the literature on 
surgical options for decompression at the craniocervical junction and offer 
our surgical case as a treatment option for patients in this rare clinical 
situation. © 2005 Elsevier Ltd. All rights reserved.
EMTREE DRUG INDEX TERMS
  bone morphogenetic protein; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Chiari Frommel syndrome (complication); craniovertebral stenosis (complication, surgery, therapy); odontoid panus (complication); spine disease (complication, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  anamnesis; article; bone density; brain; brain decompression; brain ventricle peritoneum shunt; case report; cerebrospinal fluid flow; computer assisted tomography; craniectomy; craniofacial malformation; craniofacial synostosis; Crouzon syndrome; developmental disorder; emergency ward; exophthalmos; female; gait disorder; headache; human; hypertelorism; immobilization; intensive care; laminectomy; leg; lethargy; muscle weakness; nuclear magnetic resonance imaging; occipital bone; orthosis; preschool child; priority journal; rib graft; somatosensory evoked potential; spinal cord; spinal cord compression; stomach tube; tracheostomy; traction therapy; ultrasound; walking; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005556188
MEDLINE PMID
  16242933 (http://www.ncbi.nlm.nih.gov/pubmed/16242933)
PUI
  L41744095
DOI
  10.1016/j.jocn.2004.11.015
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jocn.2004.11.015
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09675868&id=doi:10.1016%2Fj.jocn.2004.11.015&atitle=Chiari+malformation+and+odontoid+panus+causing+craniovertebral+stenosis+in+a+child+with+Crouzon%27s+syndrome&stitle=J.+Clin.+Neurosci.&title=Journal+of+Clinical+Neuroscience&volume=12&issue=8&spage=964&epage=967&aulast=Dickerman&aufirst=Rob+D.&auinit=R.D.&aufull=Dickerman+R.D.&coden=JCNUE&isbn=&pages=964-967&date=2005&auinit1=R&auinitm=D
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 880
TITLE
  Bench-to-bedside review: Early tracheostomy in critically ill trauma 
patients
AUTHOR NAMES
  Shirawi N.; Arabi Y.
AUTHOR ADDRESSES
  (Shirawi N., drnehad@yahoo.com) Intensive Care Department, King Abdulaziz 
Medical City, Riyadh, Saudi Arabia.
(Arabi Y., arabi@ngha.med.sa) Intensive Care Department, King Abdulaziz Bin 
Saud University, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
CORRESPONDENCE ADDRESS
  Y. Arabi, Intensive Care Department, King Abdulaziz Medical City, King 
Abdulaziz Bin Saud University, Riyadh, Saudi Arabia. Email: 
arabi@ngha.med.sa
FULL RECORD ENTRY DATE
  2005-10-17
SOURCE
  Critical Care (2006) 10:1 Article Number: 201. Date of Publication: 17 Oct 
2005
VOLUME
  10
ISSUE
  1
DATE OF PUBLICATION
  17 Oct 2005
ISSN
  1364-8535
  1466-609X (electronic)
BOOK PUBLISHER
  BioMed Central Ltd., 34 - 42 Cleveland Street, London, United Kingdom.
ABSTRACT
  A significant proportion of trauma patients require tracheostomy during 
intensive care unit stay. The timing of this procedure remains a subject of 
debate. The decision for tracheostomy should take into consideration the 
risks and benefits of prolonged endotracheal intubation versus tracheostomy. 
Timing of tracheostomy is also influenced by the indications for the 
procedure, which include relief of upper airway obstruction, airway access 
in patients with cervical spine injury, management of retained airway 
secretions, maintenance of patent airway and airway access for prolonged 
mechanical ventilation. This review summarizes the potential advantages of 
tracheostomy versus endotracheal intubation, the different indications for 
tracheostomy in trauma patients and studies examining early versus late 
tracheostomy. It also reviews the predictors of prolonged mechanical 
ventilation, which may guide the decision regarding the timing of 
tracheostomy. © 2005 BioMed Central Ltd.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury (surgery, therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  airway obstruction (complication, surgery); artificial ventilation; blunt trauma (surgery, therapy); breathing mechanics; cervical spine injury (surgery, therapy); chronic lung disease (surgery); clinical trial; critically ill patient; early intervention; emergency care; endotracheal intubation; face fracture (surgery, therapy); face injury (surgery, therapy); head injury (surgery); hospital infection (complication, etiology); human; incidence; infection risk; intensive care unit; larynx injury (surgery, therapy); length of stay; long term care; lung dead space; maxillofacial injury (surgery, therapy); medical decision making; neck injury (surgery, therapy); nose injury (complication); patient selection; penetrating trauma (surgery, therapy); pneumonia (complication, etiology); priority journal; quality of life; respiratory distress syndrome (surgery, therapy); review; risk reduction; therapy delay; trachea injury (complication); trachea stenosis (complication); tracheotomy; treatment contraindication; treatment indication; ventilator associated pneumonia (complication); 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007351216
MEDLINE PMID
  16356202 (http://www.ncbi.nlm.nih.gov/pubmed/16356202)
PUI
  L47079853
DOI
  10.1186/cc3828
FULL TEXT LINK
  http://dx.doi.org/10.1186/cc3828
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13648535&id=doi:10.1186%2Fcc3828&atitle=Bench-to-bedside+review%3A+Early+tracheostomy+in+critically+ill+trauma+patients&stitle=Crit.+Care&title=Critical+Care&volume=10&issue=1&spage=&epage=&aulast=Shirawi&aufirst=Nehad&auinit=N.&aufull=Shirawi+N.&coden=CRCAF&isbn=&pages=-&date=2006&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 881
TITLE
  Characterizing the need for mechanical ventilation following cervical spinal 
cord injury with neurologic deficit
AUTHOR NAMES
  Como J.J.; Sutton E.R.H.; McCunn M.; Dutton R.P.; Johnson S.B.; Aarabi B.; Scalea T.M.
AUTHOR ADDRESSES
  (Como J.J., jjc0965@aol.com) Case Western Reserve University School of 
Medicine, MetroHealth Medical Center, Department of Surgery, Cleveland, OH, 
United States.
(Sutton E.R.H.) Department of Surgery, R. Adams Cowley Shock Trauma Center, 
Baltimore, MD, United States.
(McCunn M.; Dutton R.P.) Section of Trauma Anesthesiology, R. Adams Cowley 
Shock Trauma Center, Baltimore, MD, United States.
(Johnson S.B.; Scalea T.M.) Program in Trauma and Surgical Critical Care, R. 
Adams Cowley Shock Trauma Center, Baltimore, MD, United States.
(Aarabi B.) Department of Neurosurgery, University of Maryland School of 
Medicine, Baltimore, MD, United States.
(Como J.J., jjc0965@aol.com) Department of Surgery, MetroHealth Medical 
Center, 2500 MetroHealth Drive, Cleveland, OH 44109, United States.
CORRESPONDENCE ADDRESS
  J.J. Como, Department of Surgery, MetroHealth Medical Center, 2500 
MetroHealth Drive, Cleveland, OH 44109, United States. Email: 
jjc0965@aol.com
FULL RECORD ENTRY DATE
  2006-01-23
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2005) 59:4 
(912-916). Date of Publication: October 2005
VOLUME
  59
ISSUE
  4
FIRST PAGE
  912
LAST PAGE
  916
DATE OF PUBLICATION
  October 2005
ISSN
  0022-5282
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background: Patients who sustain cervical spinal cord injury (C-SCI) with 
neurologic deficit may require a definitive airway and/or prolonged 
mechanical ventilation. The purpose of this study was to characterize 
factors associated with a high risk for respiratory failure and/or the need 
for mechanical ventilation in C-SCI patients. Methods: Patients with C-SCI 
and neurologic deficit admitted to a Level I Trauma Center between July 1, 
2000 and June 30, 2002 were retrospectively reviewed for demographics, level 
and completeness of neurologic deficit, need for definitive airway, need for 
tracheostomy, need for mechanical ventilation at hospital discharge (MVDC), 
and outcomes. The level and completeness of injury were defined by American 
Spinal Injury Association standards. Results: One hundred nineteen patients 
with C-SCI and neurologic deficit were identified over this period. Of 
these, 45 were identified as complete C-SCI: 12 (27%) patients had levels of 
C1 to C4; 19 (42%) had a level of C5; and 14 (31%) had levels of C6 and 
below. There were 37 males and 8 females. There were 36 blunt and 9 
penetrating injuries. The average age of these patients was 40+/-21, and the 
average ISS was 45+/-22. Eight of the patients with complete C-SCI died, for 
a mortality of 18%. Of the 37 survivors, 92% received a definitive airway, 
81% received tracheostomy, and 51% required MVDC. All patients with complete 
injuries at the C5 level and above required a definitive airway and 
tracheostomy, and 71% of survivors required MVDC. Of the patients with 
complete injuries of C6 and below, 79% received a definitive airway, 50% 
required tracheostomy, and 15% of survivors required MVDC. Only 35% of 
incomplete injuries required a definitive airway, and only 7% required 
tracheostomy. Conclusions: The need for definitive airway control, 
tracheostomy, and ventilator dependence is significant, especially for 
patients with high complete C-SCI. Based on these results we recommend 
consideration of early intubation and tracheostomy for patients with 
complete C-SCI, especially for those with levels of C5 and above. Copyright 
© 2005 by Lippincott Williams & Wilkins, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury; neurologic disease; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; blunt trauma; cervical spine; clinical article; demography; female; hospital discharge; human; intubation; male; mortality; outcome assessment; penetrating trauma; priority journal; respiratory failure; retrospective study; review; risk factor; tracheostomy; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2006015050
MEDLINE PMID
  16374281 (http://www.ncbi.nlm.nih.gov/pubmed/16374281)
PUI
  L43048708
DOI
  10.1097/01.ta.0000187660.03742.a6
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.ta.0000187660.03742.a6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:10.1097%2F01.ta.0000187660.03742.a6&atitle=Characterizing+the+need+for+mechanical+ventilation+following+cervical+spinal+cord+injury+with+neurologic+deficit&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=59&issue=4&spage=912&epage=916&aulast=Como&aufirst=John+J.&auinit=J.J.&aufull=Como+J.J.&coden=JOTRF&isbn=&pages=912-916&date=2005&auinit1=J&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 882
TITLE
  Editorial comment
AUTHOR NAMES
  Jallo J.
AUTHOR ADDRESSES
  (Jallo J.) Department of Neurosurgery, Temple University, .
CORRESPONDENCE ADDRESS
  J. Jallo, Department of Neurosurgery, Temple University, .
FULL RECORD ENTRY DATE
  2006-01-23
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2005) 59:4 (916). 
Date of Publication: Oct 2005
VOLUME
  59
ISSUE
  4
FIRST PAGE
  916
DATE OF PUBLICATION
  Oct 2005
ISSN
  0022-5282
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  human; intubation; neurologic disease; note; patient care; priority journal; publication; retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2006015051
PUI
  L43048709
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:&atitle=Editorial+comment&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=59&issue=4&spage=916&epage=&aulast=Jallo&aufirst=Jack&auinit=J.&aufull=Jallo+J.&coden=JOTRF&isbn=&pages=916-&date=2005&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 883
TITLE
  Traumatic retropharyngeal hematoma: A rare and critical pathology needed for 
early diagnosis
AUTHOR NAMES
  Duvillard C.; Ballester M.; Romanet P.
AUTHOR ADDRESSES
  (Duvillard C., christian.duvillard@chu-dijon.fr; Ballester M.; Romanet P.) 
Service d'Oto-Rhino-Laryngologie, de Chirurgie Cervico-Faciale et de 
Phoniatrie, Hôpital Général, 3 rue du Faubourg Raines, 21033 Dijon Cedex, 
France.
CORRESPONDENCE ADDRESS
  C. Duvillard, Service d'Oto-Rhino-Laryngologie, de Chirurgie Cervico-Faciale 
et de Phoniatrie, Hôpital Général, 3 rue du Faubourg Raines, 21033 Dijon 
Cedex, France. Email: christian.duvillard@chu-dijon.fr
FULL RECORD ENTRY DATE
  2005-10-31
SOURCE
  European Archives of Oto-Rhino-Laryngology (2005) 262:9 (713-715). Date of 
Publication: September 2005
VOLUME
  262
ISSUE
  9
FIRST PAGE
  713
LAST PAGE
  715
DATE OF PUBLICATION
  September 2005
ISSN
  0937-4477
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Retropharyngeal hematoma occurs rarely. It is located just in front of the 
cervical spine. Many circumstances can lead to its development. A trauma 
and/or anticoagulants are often key factors. The assessment must be made 
extremely carefully as such a hematoma can induce an airway compromise. 
Trauma being a key factor, it can also present with cervical spine 
fractures, increasing the risks. Two different cases of retropharyngeal 
hematomas are reported. The first case required surgical management with 
tracheotomy, per-oral drainage and naso-gastric tube feeding. A total 
recovery was obtained in 2 weeks. The second patient underwent medical 
treatment (methylprednisolone), and recovery was obtained in 6 days. Surgery 
for retropharyngeal hematoma is not always mandatory. It becomes necessary 
when a major dysphagia or dyspnea occurs. In other cases, medical treatment 
and close observation are usually sufficient. © Springer-Verlag 2005.
EMTREE DRUG INDEX TERMS
  methylprednisolone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hematoma (diagnosis, drug therapy, surgery); pharynx tumor (diagnosis, drug therapy, surgery); tumor diagnosis; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; cancer surgery; case report; clinical feature; computer assisted tomography; human; male; nose feeding; physical examination; priority journal; surgical drainage; tracheostomy; 
CAS REGISTRY NUMBERS
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005456214
MEDLINE PMID
  16133468 (http://www.ncbi.nlm.nih.gov/pubmed/16133468)
PUI
  L41428260
DOI
  10.1007/s00405-004-0767-3
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00405-004-0767-3
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09374477&id=doi:10.1007%2Fs00405-004-0767-3&atitle=Traumatic+retropharyngeal+hematoma%3A+A+rare+and+critical+pathology+needed+for+early+diagnosis&stitle=Eur.+Arch.+Oto-Rhino-Laryngol.&title=European+Archives+of+Oto-Rhino-Laryngology&volume=262&issue=9&spage=713&epage=715&aulast=Duvillard&aufirst=Christian&auinit=C.&aufull=Duvillard+C.&coden=EAOTE&isbn=&pages=713-715&date=2005&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 884
TITLE
  Cervical spine fracture in the ankylosing spondylitis patient [1]
AUTHOR NAMES
  Coleman J.A.
AUTHOR ADDRESSES
  (Coleman J.A.)
FULL RECORD ENTRY DATE
  2005-08-11
SOURCE
  Journal of the American College of Surgeons (2005) 201:2 (318). Date of 
Publication: August 2005
VOLUME
  201
ISSUE
  2
FIRST PAGE
  318
DATE OF PUBLICATION
  August 2005
ISSN
  1072-7515
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing spondylitis; cervical spine fracture (complication); 
EMTREE MEDICAL INDEX TERMS
  clinical feature; endotracheal intubation; endotracheal tube; fiber optics; hematoma; human; laryngoscope; letter; lung clearance; medical information; nurse; priority journal; senescence; stridor; tracheotomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2005323293
MEDLINE PMID
  16038832 (http://www.ncbi.nlm.nih.gov/pubmed/16038832)
PUI
  L40994968
DOI
  10.1016/j.jamcollsurg.2005.04.030
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jamcollsurg.2005.04.030
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10727515&id=doi:10.1016%2Fj.jamcollsurg.2005.04.030&atitle=Cervical+spine+fracture+in+the+ankylosing+spondylitis+patient+%5B1%5D&stitle=J.+Am.+Coll.+Surg.&title=Journal+of+the+American+College+of+Surgeons&volume=201&issue=2&spage=318&epage=&aulast=Coleman&aufirst=Jack+A.&auinit=J.A.&aufull=Coleman+J.A.&coden=JACSE&isbn=&pages=318-&date=2005&auinit1=J&auinitm=A
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 885
TITLE
  Letter to the editor (multiple letters) [1]
AUTHOR NAMES
  Kanna B.; Ayman H.A.; Soni A.; Arabi Y.; Haddad S.; Shirawi N.; Al Shimemeri A.
AUTHOR ADDRESSES
  (Kanna B.; Soni A.) Lincoln Hospital, Weill Medical College of Cornell 
University, New York, NY, United States.
(Ayman H.A.) Department of Internal Medicine, Lincoln Hospital, Bronx, NY, 
United States.
(Arabi Y.; Haddad S.; Shirawi N.; Al Shimemeri A.)
CORRESPONDENCE ADDRESS
  B. Kanna, Lincoln Hospital, Weill Medical College of Cornell University, New 
York, NY, United States.
FULL RECORD ENTRY DATE
  2005-08-30
SOURCE
  Critical Care (2005) 9:4 (414-416). Date of Publication: Aug 2005
VOLUME
  9
ISSUE
  4
FIRST PAGE
  414
LAST PAGE
  416
DATE OF PUBLICATION
  Aug 2005
ISSN
  1364-8535
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; clinical practice; comorbidity; critical illness; endotracheal intubation; financial management; health care facility; health care personnel; hospital discharge; human; intensive care; intensive care unit; length of stay; letter; maxillofacial injury; multivariate analysis; patient care; patient selection; priority journal; resource management; spinal cord injury (surgery); spine stabilization; time; treatment outcome; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2005368867
PUI
  L41136287
DOI
  10.1186/cc3043
FULL TEXT LINK
  http://dx.doi.org/10.1186/cc3043
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13648535&id=doi:10.1186%2Fcc3043&atitle=Letter+to+the+editor+%28multiple+letters%29+%5B1%5D&stitle=Crit.+Care&title=Critical+Care&volume=9&issue=4&spage=414&epage=416&aulast=Kanna&aufirst=Balavenkatesh&auinit=B.&aufull=Kanna+B.&coden=CRCAF&isbn=&pages=414-416&date=2005&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 886
TITLE
  Respiratory management of the infant with type 1 spinal muscular atrophy
AUTHOR NAMES
  Bush A.; Fraser J.; Jardine E.; Paton J.; Simonds A.; Wallis C.
AUTHOR ADDRESSES
  (Bush A., a.bush@rbh.nthames.nhs.uk) Department of Paediatric Respiratory 
Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United 
Kingdom.
(Bush A., a.bush@rbh.nthames.nhs.uk; Simonds A.) Royal Brompton Hospital, 
London, United Kingdom.
(Fraser J.) Paediatric Intensive Care Unit, Bristol Royal Hospital for 
Children, Bristol, United Kingdom.
(Jardine E.; Paton J.) Division of Developmental Medicine, University of 
Glasgow, Royal Hospital for Sick Children, Glasgow, United Kingdom.
(Wallis C.) Great Ormond Street Hospital, London, United Kingdom.
CORRESPONDENCE ADDRESS
  A. Bush, Department of Paediatric Respiratory Medicine, Royal Brompton 
Hospital, Sydney Street, London SW3 6NP, United Kingdom. Email: 
a.bush@rbh.nthames.nhs.uk
FULL RECORD ENTRY DATE
  2005-07-18
SOURCE
  Archives of Disease in Childhood (2005) 90:7 (709-711). Date of Publication: 
July 2005
VOLUME
  90
ISSUE
  7
FIRST PAGE
  709
LAST PAGE
  711
DATE OF PUBLICATION
  July 2005
ISSN
  0003-9888
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  A recent paper has highlighted the differences in the respiratory management 
offered to infants with type 1 spinal muscular atrophy (SMA-1). Current 
views appear polarised between those who would offer nothing, to those who 
would proceed as far even as tracheostomy and long term invasive ventilation 
for these infants. Here we offer a personal view, as a possible template for 
managing a vexed and emotional problem. The complex nonrespiratory aspects 
of the holistic care of these infants will not be discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy (therapy); Werdnig Hoffmann disease (therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; child health care; chronic obstructive lung disease (therapy); disease course; human; intermittent positive pressure ventilation; palliative therapy; patient care; priority journal; prognosis; quality of life; respiratory failure; review; survival; tracheostomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005298861
MEDLINE PMID
  15970612 (http://www.ncbi.nlm.nih.gov/pubmed/15970612)
PUI
  L40922501
DOI
  10.1136/adc.2004.065961
FULL TEXT LINK
  http://dx.doi.org/10.1136/adc.2004.065961
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039888&id=doi:10.1136%2Fadc.2004.065961&atitle=Respiratory+management+of+the+infant+with+type+1+spinal+muscular+atrophy&stitle=Arch.+Dis.+Child.&title=Archives+of+Disease+in+Childhood&volume=90&issue=7&spage=709&epage=711&aulast=Bush&aufirst=A.&auinit=A.&aufull=Bush+A.&coden=ADCHA&isbn=&pages=709-711&date=2005&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 887
TITLE
  There are other ways to manage spinal muscular atrophy type 1 [10]
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu) UMDNJ-New Jersey Medical School, Newark, NJ, 
United States.
(Bach J.R., bachjr@umdnj.edu) UMDNJ-New Jersey Medical School, Department of 
Physical Medicine and Rehabilitation, University Hospital, 150th St, Newark, 
NJ 07871, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, UMDNJ-New Jersey Medical School, Department of Physical Medicine 
and Rehabilitation, University Hospital, 150th St, Newark, NJ 07871, United 
States. Email: bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2007-03-22
SOURCE
  Chest (2005) 127:4 (1463). Date of Publication: April 2005
VOLUME
  127
ISSUE
  4
FIRST PAGE
  1463
DATE OF PUBLICATION
  April 2005
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  clinical practice; disease classification; disease severity; funnel chest; gastrostomy; human; letter; outpatient care; oximetry; patient care; positive end expiratory pressure; priority journal; respiratory failure; tracheotomy; treatment outcome; vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007079262
PUI
  L46224326
DOI
  10.1378/chest.127.4.1463
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.127.4.1463
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.127.4.1463&atitle=There+are+other+ways+to+manage+spinal+muscular+atrophy+type+1+%5B10%5D&stitle=Chest&title=Chest&volume=127&issue=4&spage=1463&epage=&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=CHETB&isbn=&pages=1463-&date=2005&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 888
TITLE
  There are other ways to manage spinal muscular atrophy type 1 [11]
AUTHOR NAMES
  Ioos C.
AUTHOR ADDRESSES
  (Ioos C., Christine.ioos@rpc.ap-hop-paris.fr) Hôpital Raymond Poincaré, 
Garches, France.
(Ioos C., Christine.ioos@rpc.ap-hop-paris.fr) Hôpital Raymond Poincare, 104 
Blvd Raymond Poincaré, Garches, 92380, France.
CORRESPONDENCE ADDRESS
  C. Ioos, Hôpital Raymond Poincare, 104 Blvd Raymond Poincaré, Garches, 
92380, France. Email: Christine.ioos@rpc.ap-hop-paris.fr
FULL RECORD ENTRY DATE
  2007-03-22
SOURCE
  Chest (2005) 127:4 (1463-1464). Date of Publication: April 2005
VOLUME
  127
ISSUE
  4
FIRST PAGE
  1463
LAST PAGE
  1464
DATE OF PUBLICATION
  April 2005
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; aspiration pneumonia; breathing exercise; dysphagia; funnel chest (prevention, therapy); human; International Classification of Diseases; letter; lung congestion; nose breathing; percussion; positive end expiratory pressure; priority journal; quality of life; respiratory distress (therapy); respiratory failure (therapy); sudden death; tracheostomy; vital capacity; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2007079263
PUI
  L46224327
DOI
  10.1378/chest.127.4.1463
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.127.4.1463
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.127.4.1463&atitle=There+are+other+ways+to+manage+spinal+muscular+atrophy+type+1+%5B11%5D&stitle=Chest&title=Chest&volume=127&issue=4&spage=1463&epage=1464&aulast=Ioos&aufirst=Christine&auinit=C.&aufull=Ioos+C.&coden=CHETB&isbn=&pages=1463-1464&date=2005&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2008 Elsevier B.V., All rights reserved.

RECORD 889
TITLE
  There are other ways to manage spinal muscular atrophy type 1.
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.)
CORRESPONDENCE ADDRESS
  J.R. Bach,
FULL RECORD ENTRY DATE
  2005-06-01
SOURCE
  Chest (2005) 127:4 (1463; author reply 1463-1464). Date of Publication: Apr 
2005
VOLUME
  127
ISSUE
  4
DATE OF PUBLICATION
  Apr 2005
ISSN
  0012-3692
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hereditary spinal muscular atrophy (therapy); 
EMTREE MEDICAL INDEX TERMS
  child; human; note; tracheotomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  15821239 (http://www.ncbi.nlm.nih.gov/pubmed/15821239)
PUI
  L40708397
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:&atitle=There+are+other+ways+to+manage+spinal+muscular+atrophy+type+1.&stitle=Chest&title=Chest&volume=127&issue=4&spage=&epage=&aulast=Bach&aufirst=John+R&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=-&date=2005&auinit1=J&auinitm=R
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 890
TITLE
  Prediction of tracheostomy tube size for paediatric long-term ventilation: 
An audit of children with spinal cord injury
AUTHOR NAMES
  Behl S.; Watt J.W.H.
AUTHOR ADDRESSES
  (Behl S.; Watt J.W.H., John.Watt@southportandormskirk.nhs.uk) Department of 
Anaesthesia, Spinal Injuries Centre, Southport/Ormskirk Hosp. NHS Trust, 
Town Lane, Southport PR8 6PN, United Kingdom.
(Behl S.) Liverpool Women's Hospital, Crown Street, Liverpool L8 7SS, United 
Kingdom.
CORRESPONDENCE ADDRESS
  J.W.H. Watt, Department of Anaesthesia, Spinal Injuries Centre, 
Southport/Ormskirk Hosp. NHS Trust, Town Lane, Southport PR8 6PN, United 
Kingdom. Email: John.Watt@southportandormskirk.nhs.uk
FULL RECORD ENTRY DATE
  2005-01-20
SOURCE
  British Journal of Anaesthesia (2005) 94:1 (88-91). Date of Publication: 
January 2005
VOLUME
  94
ISSUE
  1
FIRST PAGE
  88
LAST PAGE
  91
DATE OF PUBLICATION
  January 2005
ISSN
  0007-0912
BOOK PUBLISHER
  Oxford University Press, Great Clarendon Street, Oxford, United Kingdom.
ABSTRACT
  Background. There are no published data to predict tracheostomy tube size as 
growth proceeds in children requiring long-term ventilation. Methods. A 
retrospective audit was undertaken of children having long-term ventilation, 
managed from the Southport spinal injuries unit. The dates of step-up in 
size of tracheostomy tube were noted together with the tube inside and 
outside diameters (ID and OD) and the lateral tracheal diameter. The data 
were aggregated for each increment in tube size to calculate the Pearson 
correlation coefficients for age and weight of the children. Linear 
regression was then used to generate predictive equations based on age and 
weight. Results. Out of 12 children, data from seven boys and two girls, 
with a mean age of 5.9 (range 1.5-13.75) yr, were obtained. Average length 
of follow-up was 7 yr, with an average of 3.5 tube changes per patient 
equating to a larger tube every 2 yr. The inside and outside tracheal tube 
diameters, as well as the lateral tracheal diameter, correlated 
significantly with age and weight (P<0.01). The appropriate tracheostomy 
tube internal diameter is conveniently expressed by the formula: ID 
(mm)=(age yr)/3+3.5 Conclusions. The step-up in size of the tracheostomy 
tube as growth proceeds should be undertaken as a planned procedure at least 
every 2 yr to avoid nocturnal desaturation. Age appears to be a convenient 
and reliable predictor. © The Board of Management and Trustees of the 
British Journal of Anaesthesia 2004.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; spinal cord injury (therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; age; article; body weight; breathing circuit; calculation; child; circadian rhythm; clinical article; clinical audit; correlation coefficient; equipment design; female; follow up; human; linear regression analysis; long term care; male; mathematical analysis; oxygen saturation; pediatrics; prediction; priority journal; United Kingdom; 
DEVICE TRADE NAMES
  6PDL  Shiley

  Biesalski  Rusch

  Blue line ultra  Sims Portex

  Blue line  Portex

  Hyperflex  Bivona

  Silicone  Bivona

  Trac/comfort  Boston

  Trac/flex  Boston

DEVICE MANUFACTURERS
  Bivona
  Boston
  Portex
  Rusch
  Shiley
  Silver Negus
  Sims Portex
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Pediatrics and Pediatric Surgery (7)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005023812
MEDLINE PMID
  15486000 (http://www.ncbi.nlm.nih.gov/pubmed/15486000)
PUI
  L40074913
DOI
  10.1093/bja/aeh296
FULL TEXT LINK
  http://dx.doi.org/10.1093/bja/aeh296
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00070912&id=doi:10.1093%2Fbja%2Faeh296&atitle=Prediction+of+tracheostomy+tube+size+for+paediatric+long-term+ventilation%3A+An+audit+of+children+with+spinal+cord+injury&stitle=Br.+J.+Anaesth.&title=British+Journal+of+Anaesthesia&volume=94&issue=1&spage=88&epage=91&aulast=Behl&aufirst=&auinit=S.&aufull=Behl+S.&coden=BJANA&isbn=&pages=88-91&date=2005&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 891
TITLE
  Airway management of mucopolysaccharidosis with cervical spine involvement
AUTHOR NAMES
  Sahin A.; Dal D.; Ocal T.; Aypar U.
AUTHOR ADDRESSES
  (Sahin A., asahin@hacettepe.edu.tr; Dal D.; Ocal T.; Aypar U.) Department of 
Anesthesiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
CORRESPONDENCE ADDRESS
  A. Sahin, Department of Anesthesiology, Faculty of Medicine, Hacettepe 
University, Ankara, Turkey. Email: asahin@hacettepe.edu.tr
FULL RECORD ENTRY DATE
  2005-04-03
SOURCE
  Neurosciences (2005) 10:1 (103-105). Date of Publication: Jan 2005
VOLUME
  10
ISSUE
  1
FIRST PAGE
  103
LAST PAGE
  105
DATE OF PUBLICATION
  Jan 2005
ISSN
  1319-6138
ABSTRACT
  Mucopolysaccharidoses are a group of inherited disorders occasionally 
accompanied by cervical spine involvement complicating tracheal intubation. 
In this study, we review and discuss 5 cases of mucopolysaccharidosis with 
cervical spinal involvement.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  atropine (drug combination); diazepam (drug combination); lidocaine (drug dose, topical drug administration); propofol (drug dose, intravenous drug administration); suxamethonium; thiopental; 
EMTREE DRUG INDEX TERMS
  midazolam (drug combination); sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Morquio syndrome; spine disease; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; atlantoaxial subluxation (surgery); cervical spine; clinical article; clinical feature; diaphragm hernia (congenital disorder, surgery); endotracheal intubation; faintness; funnel chest (congenital disorder); human; limb malformation (congenital disorder); male; micrognathia (congenital disorder); muscle hypotonia (congenital disorder); pediatric anesthesia; pigeon thorax (congenital disorder); school child; symptom; tracheotomy; vertebral canal stenosis (surgery); 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
  diazepam (439-14-5)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  propofol (2078-54-8)
  sevoflurane (28523-86-6)
  suxamethonium (306-40-1, 71-27-2)
  thiopental (71-73-8, 76-75-5)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005129484
PUI
  L40385443
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13196138&id=doi:&atitle=Airway+management+of+mucopolysaccharidosis+with+cervical+spine+involvement&stitle=Neurosciences&title=Neurosciences&volume=10&issue=1&spage=103&epage=105&aulast=Sahin&aufirst=Altan&auinit=A.&aufull=Sahin+A.&coden=NRSAB&isbn=&pages=103-105&date=2005&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 892
TITLE
  Surgical management of a Klippel-Feil patient with basilar invagination and 
an intramedullary lipoma: A case report
AUTHOR NAMES
  Avci E.; Burke T.; Fossett D.
AUTHOR ADDRESSES
  (Avci E., avciemel@hotmail.com) Department of Neurosurgery, Harran 
University, Şanliurfa, Turkey.
(Burke T.; Fossett D.) Department of Neurosurgery, George Washington 
University, Washington, DC, United States.
(Avci E., avciemel@hotmail.com) Harran Üniversitesi, Tip Fakültesi, 
Araştirma Hastanesi Beyin Cerrahisi, Şanliurfa, Turkey.
CORRESPONDENCE ADDRESS
  E. Avci, Harran Üniversitesi, Tip Fakültesi, Araştirma Hastanesi Beyin 
Cerrahisi, Şanliurfa, Turkey. Email: avciemel@hotmail.com
FULL RECORD ENTRY DATE
  2007-03-19
SOURCE
  Turkish Neurosurgery (2005) 15:1 (23-26). Date of Publication: 2005
VOLUME
  15
ISSUE
  1
FIRST PAGE
  23
LAST PAGE
  26
DATE OF PUBLICATION
  2005
ISSN
  1019-5149
BOOK PUBLISHER
  Turkish Neurosurgical Society
ABSTRACT
  Patients with Klippel-Feil syndrome (KFS) and associated craniocervical 
junction abnormalities are at high risk for the development of progressive 
neurologic deficits. A 60-year-old male patient with Klippel-Feil syndrome 
was admitted to the emergency room with an 8-year history of a progressive 
spastic quadraparesis which began with numbness in the right lower 
extremity. Neurologic status of the patient improved significantly following 
posterior decompression and stabilization. Dramatic resolution of his 
myelopathy with the initial procedure led to postponing the second 
procedure. Early post-operative improvement in neurologic function after the 
initial procedure may be misleading. For this reason, the two-staged ventral 
and dorsal decompression was suggested for the restoration and preservation 
of neurologic function.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Klippel Feil syndrome (surgery); lipoma; 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; article; case report; decompression surgery; gastrostomy; human; kyphoscoliosis; laminectomy; male; neurologic examination; paralysis; paresthesia; postoperative period; spinal cord disease (surgery); spine stabilization; tracheostomy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, Turkish
EMBASE ACCESSION NUMBER
  2007068338
PUI
  L46196731
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10195149&id=doi:&atitle=Surgical+management+of+a+Klippel-Feil+patient+with+basilar+invagination+and+an+intramedullary+lipoma%3A+A+case+report&stitle=Turk.+Neurosurg.&title=Turkish+Neurosurgery&volume=15&issue=1&spage=23&epage=26&aulast=Avci&aufirst=Emel&auinit=E.&aufull=Avci+E.&coden=TUNEE&isbn=&pages=23-26&date=2005&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 893
TITLE
  Cardiac arrest: Recent advances in recognition and management
AUTHOR NAMES
  Zaidi S.; Senthuran S.; Naik M.
AUTHOR ADDRESSES
  (Zaidi S.) Dept. of Anaesthesia/Intensive Care, Addenbrookes Hospital, 
Cambridge CB2 2QQ, United Kingdom.
(Senthuran S.) Department of Intensive Care, Royal Brisbane Hospital, 
Brisbane, QLD, Australia.
(Naik M.) Dept. of Anaesthesia/Intensive Care, Norfolk/Norwich University 
Hospital, Norwich NR4 7UY, United Kingdom.
CORRESPONDENCE ADDRESS
  S. Zaidi, Dept. of Anaesthesia/Intensive Care, Addenbrookes Hospital, 
Cambridge CB2 2QQ, United Kingdom.
FULL RECORD ENTRY DATE
  2005-02-15
SOURCE
  CPD Journal Acute Medicine (2004) 3:3 (103-109). Date of Publication: 2004
VOLUME
  3
ISSUE
  3
FIRST PAGE
  103
LAST PAGE
  109
DATE OF PUBLICATION
  2004
ISSN
  1476-5063
ABSTRACT
  The features of cardiac arrest will be familiar to any reader who has 
recently undertaken an Advanced Life Support course. Rather than reproducing 
algorithms which should be readily available in all UK hospitals, this 
article emphasises the importance of early recognition and prevention, and 
looks at some of the more recent advances in resuscitation technique.
EMTREE DRUG INDEX TERMS
  amiodarone (drug comparison, drug therapy); antiarrhythmic agent (adverse drug reaction); antidepressant agent (adverse drug reaction); beta adrenergic receptor blocking agent (adverse drug reaction); digoxin (adverse drug reaction); epinephrine (drug comparison, drug therapy); lidocaine (drug comparison, drug therapy); vasopressin (drug comparison, drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  heart arrest (complication, diagnosis, disease management, drug therapy, 
epidemiology, etiology, prevention, side effect); 
EMTREE MEDICAL INDEX TERMS
  algorithm; aortic arch syndrome; assisted ventilation; breathing rate; cardiomyopathy; chronic obstructive lung disease; clinical feature; clinical protocol; coronary artery blood flow; death; defibrillator; diastolic blood pressure; drowning; electrolyte disturbance; emergency health service; head injury; health care access; health care organization; health practitioner; heart arrhythmia; heart infarction; heart rate; heart ventricle fibrillation; high risk patient; hospital patient; human; human rights; hypertension; hypothermia; hypovolemia; hypoxia; ischemia; legal aspect; long term care; lung embolism; medical decision making; metabolic acidosis; mortality; myocarditis; neurologic disease; practice guideline; respiratory tract disease; resuscitation; review; risk factor; spinal cord injury; survival rate; systolic blood pressure; temperature; tension; tracheostomy; traffic accident; treatment outcome; tricuspid valve disease; unconsciousness; United Kingdom; vascular resistance; 
CAS REGISTRY NUMBERS
  adrenalin (51-43-4, 55-31-2, 6912-68-1)
  amiodarone (1951-25-3, 19774-82-4, 62067-87-2)
  digoxin (20830-75-5, 57285-89-9)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  vasopressin (11000-17-2)
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005060171
PUI
  L40186010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14765063&id=doi:&atitle=Cardiac+arrest%3A+Recent+advances+in+recognition+and+management&stitle=CPD+J.+Acute+Med.&title=CPD+Journal+Acute+Medicine&volume=3&issue=3&spage=103&epage=109&aulast=Zaidi&aufirst=Suhail&auinit=S.&aufull=Zaidi+S.&coden=CJAMA&isbn=&pages=103-109&date=2004&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 894
TITLE
  Predictors to dysphagia and recovery after cervical spinal cord injury 
during acute rehabilitation
AUTHOR NAMES
  Brady S.; Miserendino R.; Statkus D.; Springer T.; Hakel M.; Stambolis V.
AUTHOR ADDRESSES
  (Brady S.; Miserendino R.; Statkus D.; Stambolis V.) Spinal Cord Injury 
Program, Marianjoy Rehabilitation Hospital, Wheaton, IL, United States.
(Springer T.; Hakel M.) Department of Research and Education, Madonna 
Rehabilitation Hospital, Lincoln, NE, United States.
CORRESPONDENCE ADDRESS
  S. Brady, Spinal Cord Injury Program, Marianjoy Rehabilitation Hospital, 
Wheaton, IL, United States.
FULL RECORD ENTRY DATE
  2004-11-09
SOURCE
  Journal of Applied Research (2004) 4:1 (1-11). Date of Publication: 2004
VOLUME
  4
ISSUE
  1
FIRST PAGE
  1
LAST PAGE
  11
DATE OF PUBLICATION
  2004
ISSN
  1537-064X
ABSTRACT
  The purpose of this retrospective study was to identify factors that predict 
dysphagia in patients following cervical spinal cord injury and to identify 
factors that predict dysphagia recovery patterns/outcomes during acute 
rehabilitation. Data were collected on 131 consecutive patients with a 
diagnosis of a cervical cervical spinal cord injury over a 27-month period 
at 2 freestanding rehabilitation hospitals. On admission, 55% (72/131) of 
the patients were treated for dysphagia. Three significant predictors were 
identified to the likelihood that the patient would present with dysphagia: 
the co-occurrence of a brain injury (P=0.003), the presence or history of a 
tracheotomy tube (P= 0.002), and undergoing a cervical spine surgery 
(P=0.02). Main dysphagia treatment outcome measures included: aspiration, 
laryngeal penetration, pharyngeal residue, days of dysphagia treatment 
provided, and the American Speech-Language-Hearing Association National 
Outcome Measurement System swallowing level discharge score. Fifty-nine of 
the 72 patients in the treatment group underwent an instrumental assessment 
of the swallow. Of these patients, aspiration was present in 39%, laryngeal 
penetration in 54%, and pharyngeal residue in 66% of the cases. Logistic 
regression analyses revealed for the outcome of aspiration, the predictor of 
a tracheotomy tube (P=0.008) was significant. For the outcome of laryngeal 
penetration, the predictors of a complete spinal cord injury (P=0.01) and 
the admission American Speech-Language-Hearing Association National Outcome 
Measurement System swallowing level admission score (P=0.018) were 
significant. For the outcome of pharyngeal residue, the predictors of an 
anterior spinal surgery (P=0.011), tracheotomy tube (P=0.004), and admission 
American Speech-Language-Hearing Association National Outcome Measurement 
System swallowing level (P=0.032) were significant. Linear regression 
analyses were completed for the outcome of dysphagia days of treatment and 
discharge American Speech-Language-Hearing Association National Outcome 
Measurement System swallowing level and several significant predictors were 
identified. Results of this study demonstrate that dysphagia does occur 
following cervical spinal cord injury, several factors may play a role in 
the patient's recovery, and this patient population can make significant 
progress with dysphagia treatment during acute rehabilitation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (rehabilitation); dysphagia; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; american speech language hearing association national outcome measurement 
system; article; aspiration; brain injury; convalescence; female; hospital admission; human; larynx injury; linear regression analysis; logistic regression analysis; male; outcomes research; pharynx; prediction; retrospective study; scoring system; spine surgery; swallowing; tracheotomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004453534
PUI
  L39406814
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1537064X&id=doi:&atitle=Predictors+to+dysphagia+and+recovery+after+cervical+spinal+cord+injury+during+acute+rehabilitation&stitle=J.+Appl.+Res.&title=Journal+of+Applied+Research&volume=4&issue=1&spage=1&epage=11&aulast=Brady&aufirst=Susan&auinit=S.&aufull=Brady+S.&coden=JAROB&isbn=&pages=1-11&date=2004&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 895
TITLE
  Myotonic dystrophy presenting as new-onset hand weakness and recurrent 
pneumonia in a patient with paraplegia: A case report
AUTHOR NAMES
  Carver R.T.; Boysel L.C.; Marciniak C.M.; Nussbaum S.B.
AUTHOR ADDRESSES
  (Carver R.T., ryantcarver@yahoo.com; Boysel L.C.; Marciniak C.M.; Nussbaum 
S.B.) Dept. of Phys. Med. and Rehab., NW Univ. the Rehab. Inst. of Chicago, 
Chicago, IL, United States.
(Carver R.T., ryantcarver@yahoo.com) Chelsea Back Care, 775 S Main St, 
Chelsea, MI, United States.
CORRESPONDENCE ADDRESS
  R.T. Carver, Dept. of Phys. Med. and Rehab., NW Univ. the Rehab. Inst. of 
Chicago, Chicago, IL, United States. Email: ryantcarver@yahoo.com
FULL RECORD ENTRY DATE
  2004-11-16
SOURCE
  Archives of Physical Medicine and Rehabilitation (2004) 85:11 (1896-1898). 
Date of Publication: November 2004
VOLUME
  85
ISSUE
  11
FIRST PAGE
  1896
LAST PAGE
  1898
DATE OF PUBLICATION
  November 2004
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Carver RT, Boysel C, Marciniak CM, Nussbaum SB. Myotonic dystrophy 
presenting as new-onset hand weakness and recurrent pneumonia in a patient 
with paraplegia: a case report. Arch Phys Med Rehabil 2004;85:1896-8. We 
describe a previously independent T11 paraplegic patient who had 
delayed-onset hand weakness and recurrent pneumonia caused by myotonic 
dystrophy. A man in his late thirties suffered a thoracic spinal cord injury 
(SCI) from a gunshot wound at the age of 17 years, with resultant T11 
American Spinal Injury Association class A paraplegia. He lived 
independently until the age of 36 years when he was hospitalized multiple 
times for pneumonia. During a rehabilitation stay after one of the acute 
hospitalizations, the patient's hand weakness and diffuse muscular atrophy 
were noted. Electrodiagnostic testing was performed, which showed myotonic 
discharges. Genetic testing was consistent with myotonic dystrophy. This 
case shows the importance of considering causes of weakness that affect the 
population as a whole when evaluating a patient with SCI who presents with 
delayed-onset weakness. © 2004 by the American Congress of Rehabilitation 
Medicine and the American Academy of Physical Medicine and Rehabilitation.
EMTREE DRUG INDEX TERMS
  etidronic acid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  muscle weakness (complication, etiology); myotonic dystrophy (complication, diagnosis, etiology); paraplegia (etiology, rehabilitation); pneumonia; spine injury (etiology, rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; article; case report; clinical feature; death; disease association; electrodiagnosis; gunshot injury; heterotopic ossification (complication, drug therapy); hospitalization; human; male; medical assessment; motor nerve conduction; motor unit potential; muscle strength; neurologic examination; physical examination; reflex; sensory nerve conduction; tracheostomy; 
CAS REGISTRY NUMBERS
  etidronic acid (2809-21-4, 3794-83-0, 58449-82-4, 7414-83-7)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  General Pathology and Pathological Anatomy (5)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004465217
MEDLINE PMID
  15520988 (http://www.ncbi.nlm.nih.gov/pubmed/15520988)
PUI
  L39441151
DOI
  10.1016/j.apmr.2003.08.111
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.apmr.2003.08.111
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2Fj.apmr.2003.08.111&atitle=Myotonic+dystrophy+presenting+as+new-onset+hand+weakness+and+recurrent+pneumonia+in+a+patient+with+paraplegia%3A+A+case+report&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=85&issue=11&spage=1896&epage=1898&aulast=Carver&aufirst=Ryan+T.&auinit=R.T.&aufull=Carver+R.T.&coden=APMHA&isbn=&pages=1896-1898&date=2004&auinit1=R&auinitm=T
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 896
TITLE
  Intubating laryngeal mask airway allows tracheal intubation when the 
cervical spine is immobilized by a rigid collar
AUTHOR NAMES
  Komatsu R.; Nagata O.; Kamata K.; Yamagata K.; Sessler D.I.; Ozaki M.
AUTHOR ADDRESSES
  (Komatsu R.; Nagata O.; Kamata K.; Yamagata K.; Ozaki M.) Department of 
Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan.
(Sessler D.I., sessler@louisville.edu) Outcomes Research Institute, Dept. of 
Anesthesiology/Pharmacology, University of Louisville, Louisville, KY, 
United States.
CORRESPONDENCE ADDRESS
  D.I. Sessler, Outcomes Research Institute, Dept. of 
Anesthesiology/Pharmacology, University of Louisville, Louisville, KY, 
United States. Email: sessler@louisville.edu
FULL RECORD ENTRY DATE
  2004-11-16
SOURCE
  British Journal of Anaesthesia (2004) 93:5 (655-659). Date of Publication: 
November 2004
VOLUME
  93
ISSUE
  5
FIRST PAGE
  655
LAST PAGE
  659
DATE OF PUBLICATION
  November 2004
ISSN
  0007-0912
BOOK PUBLISHER
  Oxford University Press, Great Clarendon Street, Oxford, United Kingdom.
ABSTRACT
  Background. An intubating laryngeal mask airway (ILMA) facilitates tracheal 
intubation with the neck in neutral position, which is similar to the neck 
position maintained by a rigid cervical collar. However, a cervical collar 
virtually obliterates neck movement, even small movements that normally 
facilitate airway insertion. We therefore tested the hypothesis that the 
ILMA will allow tracheal intubation even in patients wearing a rigid 
cervical collar. Methods. We performed blind tracheal intubation via an ILMA 
under general anaesthesia in 50 patients with a rigid Philadelphia collar in 
place undergoing cervical spine surgery and 50 general surgical patients. 
Time required for intubation, intubation success rate, and numbers and type 
of adjusting manoeuvres used were recorded. Results. Inter-incisor distance 
was significantly smaller (4.1 (0.8) vs 4.6 (0.7) cm, mean (SD), P<0.01) and 
Mallampati scores were significantly greater (P<0.001) in the patients with 
collars. ILMA insertion took longer (30 (25) vs 22 (6) s), more patients 
required two insertion attempts (15 vs 3; P<0.005), and ventilation adequacy 
with ILMA was worse (P<0.05) in collared patients. However, there were no 
significant differences between the collars and control patients in terms of 
total time required for intubation (60 (41) vs 50 (30) s), number of 
intubation attempts, overall intubation success rate (96 vs 98%), or the 
incidence of intubation complications. Conclusions. Blind intubation through 
an ILMA is thus a reasonable strategy for controlling the airway in patients 
who are immobilized with a rigid cervical collar. © The Board of Management 
and Trustees of the British Journal of Anaesthesia 2004.
EMTREE DRUG INDEX TERMS
  fentanyl; oxygen; propofol; sevoflurane; vecuronium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; endotracheal intubation; laryngeal mask; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; anesthesia induction; article; controlled study; female; general anesthesia; human; immobilization; major clinical study; male; patient positioning; priority journal; scoring system; spine stabilization; statistical analysis; statistical significance; tracheostomy; 
CAS REGISTRY NUMBERS
  fentanyl (437-38-7)
  oxygen (7782-44-7)
  propofol (2078-54-8)
  sevoflurane (28523-86-6)
  vecuronium (50700-72-6)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004467756
MEDLINE PMID
  15321932 (http://www.ncbi.nlm.nih.gov/pubmed/15321932)
PUI
  L39451767
DOI
  10.1093/bja/aeh248
FULL TEXT LINK
  http://dx.doi.org/10.1093/bja/aeh248
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00070912&id=doi:10.1093%2Fbja%2Faeh248&atitle=Intubating+laryngeal+mask+airway+allows+tracheal+intubation+when+the+cervical+spine+is+immobilized+by+a+rigid+collar&stitle=Br.+J.+Anaesth.&title=British+Journal+of+Anaesthesia&volume=93&issue=5&spage=655&epage=659&aulast=Komatsu&aufirst=R.&auinit=R.&aufull=Komatsu+R.&coden=BJANA&isbn=&pages=655-659&date=2004&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 897
TITLE
  Tracheostomy after anterior cervical spine fixation
AUTHOR NAMES
  O'Keeffe T.; Goldman R.K.; Mayberry J.C.; Rehm C.G.; Hart R.A.
AUTHOR ADDRESSES
  (O'Keeffe T.) Department of Surgery, Portland, OR, United States.
(Goldman R.K., goldmanr@ohsu.edu; Mayberry J.C.) Trauma/Critical Care 
Section, Portland, OR, United States.
(Hart R.A.) Department of Orthopedic Surgery, Oregon Health and Science 
University, Portland, OR, United States.
(Rehm C.G.) Portland VA Medical Center, Portland, OR, United States.
(Goldman R.K., goldmanr@ohsu.edu) Division of General Surgery, Oregon Health 
and Science University, 3181 S.W. Sam Jackson Pk. Rd., L223A, Portland, OR 
97239, United States.
CORRESPONDENCE ADDRESS
  R.K. Goldman, Division of General Surgery, Oregon Health and Science 
University, 3181 S.W. Sam Jackson Pk. Rd., L223A, Portland, OR 97239, United 
States. Email: goldmanr@ohsu.edu
FULL RECORD ENTRY DATE
  2004-11-17
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2004) 57:4 
(855-860). Date of Publication: October 2004
VOLUME
  57
ISSUE
  4
FIRST PAGE
  855
LAST PAGE
  860
DATE OF PUBLICATION
  October 2004
ISSN
  0022-5282
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background: Patients with cervical spine injury may require both anterior 
cervical spine fusion and tracheostomy, particularly in the setting of 
associated cervical spinal cord injury (SCI). Despite the close proximity of 
the two surgical incisions, we postulated that tracheostomy could be safely 
performed after anterior spine fixation. In addition, we postulated that the 
severity of motor deficits in patients with cervical spine injury would 
correlate with the need for tracheostomy. Methods: A retrospective review 
was undertaken of all adult trauma patients diagnosed with cervical spine 
fractures or cervical SCI admitted between June 1996 and June 2001 at our 
university Level I trauma center. Demographic data, severity of neurologic 
injury based on the classification of the American Spinal Injury Association 
(ASIA), complications, and use and type of tracheostomy were collected. In 
the subgroup of patients with unstable cervical spine injury that underwent 
anterior stabilization and tracheostomy, data regarding timing and technique 
of these procedures and wound outcomes were also collected. Categorical data 
were analyzed using χ(2) analysis using Yates correction when appropriate, 
with p < 0.05 considered significant. Results: During this time period, 275 
adult survivors were diagnosed with cervical spinal cord or bony injury. 
Forty-five percent of patients with SCI (27 of 60) and 14% of patients 
without SCI (30 of 215) underwent tracheostomy (p < 0.001). Moreover, on the 
basis of the ASIA classification system, 76% of ASIA A and B patients, 38% 
of ASIA C patients, 23% of ASIA D patients, and 14% of ASIA E patients were 
treated with tracheostomy (p < 0.001). In the subgroup that underwent both 
anterior spine fixation and tracheostomy (n = 17), the median time interval 
from spine fixation to airway placement was 7 days (interquartile range, 
6-10 days), with 71% of these tracheostomies performed percutaneously. No 
patient developed a wound infection or nonunion as a consequence of 
tracheostomy placement, and there were no deaths because of complications of 
either procedure. Conclusion: These data support the safety of tracheostomy 
insertion 6 to 10 days after anterior cervical spine fixation, particularly 
in the presence of cervical SCI. The presence of severe motor neurologic 
deficits was strongly associated with the use of tracheostomy in patients 
with cervical spine injury. Percutaneous tracheostomy, which is our 
technique of choice, may be advantageous in this setting by virtue of 
creating only a small wound. The optimal timing and use of tracheostomy in 
patients with cervical spine injury requires further study.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; bone injury; cervical spine; classification; clinical article; data analysis; death; demography; female; human; injury; male; patient; postoperative complication (complication); priority journal; retrospective study; review; spine injury; spine stabilization; statistical significance; surgical technique; time; treatment outcome; wound infection; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004462576
MEDLINE PMID
  15514542 (http://www.ncbi.nlm.nih.gov/pubmed/15514542)
PUI
  L39431210
DOI
  10.1097/01.TA.0000083006.48501.B2
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.TA.0000083006.48501.B2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:10.1097%2F01.TA.0000083006.48501.B2&atitle=Tracheostomy+after+anterior+cervical+spine+fixation&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=57&issue=4&spage=855&epage=860&aulast=O%27Keeffe&aufirst=Terence&auinit=T.&aufull=O%27Keeffe+T.&coden=JOTRF&isbn=&pages=855-860&date=2004&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 898
TITLE
  Increased incidence of emergency airway management after combined 
anterior-posterior cervical spine surgery
AUTHOR NAMES
  Terao Y.; Matsumoto S.; Yamashita K.; Takada M.; Inadomi C.; Fukusaki M.; Sumikawa K.
AUTHOR ADDRESSES
  (Terao Y., yoterao@na-robyo.jp; Matsumoto S.; Yamashita K.; Takada M.; 
Inadomi C.; Fukusaki M.) Department of Anesthesia, Nagasaki Rosai Hospital, 
Sasebo, Japan.
(Sumikawa K.) Division of Anesthesiology, Dept. of Translational Med. 
Sciences, Nagasaki Univ. School of Medicine, Nagasaki, Japan.
(Terao Y., yoterao@na-robyo.jp) Intensive Care Unit, Nagasaki Rosai 
Hospital, 2-12-5 Setogoe, Sasebo, Nagasaki 857-0134, Japan.
CORRESPONDENCE ADDRESS
  Y. Terao, Intensive Care Unit, Nagasaki Rosai Hospital, 2-12-5 Setogoe, 
Sasebo, Nagasaki 857-0134, Japan. Email: yoterao@na-robyo.jp
FULL RECORD ENTRY DATE
  2004-11-04
SOURCE
  Journal of Neurosurgical Anesthesiology (2004) 16:4 (282-286). Date of 
Publication: October 2004
VOLUME
  16
ISSUE
  4
FIRST PAGE
  282
LAST PAGE
  286
DATE OF PUBLICATION
  October 2004
ISSN
  0898-4921
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Among some kinds of cervical spine surgeries, combined anterior-posterior 
cervical spine surgery (CAP-CS surgery) requires prolonged operative time 
and highly invasive procedure. This study was performed to determine whether 
CAP-CS surgery was associated with increased risk of emergency airway 
management compared with other cervical spine surgeries (O-CS surgeries). 
The records of the patients who underwent cervical spine surgery between 
July 2001 and March 2003 at our institution were reviewed retrospectively, 
and we determined whether the CAP-CS surgery was associated with an 
increased risk of emergency airway management in comparison with O-CS 
surgeries, using the logistic regression analysis. A total of 165 were 
eligible for inclusion in the study. A total of 127, 20, 11, 5, and 2 
patients suffered from cervical myelopathy, traumatic cervical spinal cord 
injury, atlantoaxial dislocation, cervical spinal tumors, and cervical 
pyogenic spondylitis, respectively. The operative approaches were CAP-CS 
surgery, anterior surgery, posterior surgery, and atlantoaxial surgery in 
10, 56, 88, and 11 patients, respectively. Thus, the operative approaches 
were CAP-CS surgery in 10 patients and O-CS surgeries in 155 patients. 
Postoperative emergency airway management was required in 7 of the 10 
patients (70%) who underwent CAP-CS surgery, and 2 of the 155 patients (1%) 
who underwent O-CS surgeries. The increased risk of postoperative emergency 
airway management imposed by CAP-CS surgery was 178.5 by an odds ratio, with 
a 95% confidence interval of 25.6 to 1246. The results show that CAP-CS 
surgery provides a major risk factor for postoperative emergency airway 
management.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; lung clearance; spine surgery; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; atlantoaxial dislocation (surgery); cervical myelopathy (surgery); cervical spinal cord injury (surgery); controlled study; female; first aid; human; incidence; joint surgery; logistic regression analysis; major clinical study; male; medical record; postoperative care; postoperative complication (complication); priority journal; retrospective study; risk assessment; spinal cord tumor (surgery); spondylitis (surgery); surgical technique; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004433781
MEDLINE PMID
  15557831 (http://www.ncbi.nlm.nih.gov/pubmed/15557831)
PUI
  L39336693
DOI
  10.1097/00008506-200410000-00004
FULL TEXT LINK
  http://dx.doi.org/10.1097/00008506-200410000-00004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08984921&id=doi:10.1097%2F00008506-200410000-00004&atitle=Increased+incidence+of+emergency+airway+management+after+combined+anterior-posterior+cervical+spine+surgery&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=16&issue=4&spage=282&epage=286&aulast=Terao&aufirst=Yoshiaki&auinit=Y.&aufull=Terao+Y.&coden=JNANE&isbn=&pages=282-286&date=2004&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 899
TITLE
  Weaning of the neurologically impaired patient
AUTHOR NAMES
  Mahanes D.; Lewis R.
AUTHOR ADDRESSES
  (Mahanes D., sdm4e@virginia.edu) Nerancy Neuro Intensive Care Unit, 
University of Virginia Health System, P.O. Box 801436, 22908, 
Charlottesville, VA, United States.
(Lewis R.) Nerancy Neuro Intensive Care Unit, University of Virginia Health 
System, P.O. Box 800566, 22908, Charlottesville, VA, United States.
CORRESPONDENCE ADDRESS
  D. Mahanes, Nerancy Neuro Intensive Care Unit, University of Virginia Health 
System, P.O. Box 801436, 22908, Charlottesville, VA, United States. Email: 
sdm4e@virginia.edu
FULL RECORD ENTRY DATE
  2004-09-21
SOURCE
  Critical Care Nursing Clinics of North America (2004) 16:3 SPEC. ISS. 
(387-393). Date of Publication: September 2004
VOLUME
  16
ISSUE
  3 SPEC. ISS.
FIRST PAGE
  387
LAST PAGE
  393
DATE OF PUBLICATION
  September 2004
ISSN
  0899-5885
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  No single method has been found to be superior to the others in weaning 
patients with neurologic disease or illness. As with other patient 
populations, it is likely that simply paying attention to the processes of 
care and ensuring that care is systematic will facilitate weaning. The 
importance of weaning guidelines, protocols, and algorithms in decreasing 
ventilator duration and reducing ICU and hospital length of stay has been 
demonstrated in a number of studies [41-45]. The combination of clinical 
guidelines or protocols with an advanced practice nurse managing the 
processes of care has shown benefit for patients with brain and spinal cord 
injuries [46,47]. All patients receiving mechanical ventilation require 
attention to general care issues such as nutrition, electrolyte imbalance, 
mobility, psychologic factors, and prevention of complications. Adequate 
sleep and management of pain and anxiety contribute significantly to weaning 
success but may be difficult to assess in patients with a decreased level of 
consciousness. Data are mixed regarding whether GCS or cough reflex can be 
used as a predictor of successful extubation. In the absence of clear data 
predicting successful extubation in patients with impaired neurologic 
status, a trial extubation can be performed when standard readiness criteria 
are met, even in patients with a depressed level of consciousness. In those 
patients in whom extubation is unsuccessful, timely progression to 
tracheostomy placement is recommended. This requires careful planning and 
can only be done if good airway management resources are available. In the 
authors experience, patients with poor cough effort combined with high 
suction requirements (≥ every 2 hours) or with pooling of oral secretions 
are likely to fail extubation. For these patients, proceeding directly to 
tracheostomy without a trial of extubation may be indicated.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; neurologic disease; 
EMTREE MEDICAL INDEX TERMS
  acute disease; airway dynamics; clinical practice; coughing; extubation; Guillain Barre syndrome; hospitalization; human; intensive care unit; length of stay; myasthenia gravis; neuromuscular disease; nursing; outcomes research; patient; patient care; practice guideline; review; spinal cord injury; validation process; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  15358387 (http://www.ncbi.nlm.nih.gov/pubmed/15358387)
PUI
  L39200835
DOI
  10.1016/j.ccell.2004.03.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.ccell.2004.03.007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08995885&id=doi:10.1016%2Fj.ccell.2004.03.007&atitle=Weaning+of+the+neurologically+impaired+patient&stitle=Crit.+Care+Nurs.+Clin.+North+Am.&title=Critical+Care+Nursing+Clinics+of+North+America&volume=16&issue=3+SPEC.+ISS.&spage=387&epage=393&aulast=Mahanes&aufirst=Dea&auinit=D.&aufull=Mahanes+D.&coden=&isbn=&pages=387-393&date=2004&auinit1=D&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 900
TITLE
  Respiratory capacity course in patients with infantile spinal muscular 
atrophy
AUTHOR NAMES
  Ioos C.; Leclair-Richard D.; Mrad S.; Barois A.; Estournet-Mathiaud B.
AUTHOR ADDRESSES
  (Ioos C., christine.ioos@rpc.ap-hop-paris.fr; Leclair-Richard D.; Mrad S.; 
Barois A.; Estournet-Mathiaud B.) Department of Pediatric Neurology, Hôp. 
Raymond Poincaré, Garches, France.
(Ioos C., christine.ioos@rpc.ap-hop-paris.fr) Department of Pediatric 
Neurology, Hôp. Raymond Poincaré, 104, Blvd. Raymond Poincaré, 92380 
Garches, France.
CORRESPONDENCE ADDRESS
  C. Ioos, Department of Pediatric Neurology, Hôp. Raymond Poincaré, 104, 
Blvd. Raymond Poincaré, 92380 Garches, France. Email: 
christine.ioos@rpc.ap-hop-paris.fr
FULL RECORD ENTRY DATE
  2004-10-03
SOURCE
  Chest (2004) 126:3 (831-837). Date of Publication: September 2004
VOLUME
  126
ISSUE
  3
FIRST PAGE
  831
LAST PAGE
  837
DATE OF PUBLICATION
  September 2004
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Study objectives: To describe the clinical and respiratory course in 
infantile spinal muscular atrophy (SMA) type I, type II, and type III, and 
to evaluate the respiratory needs for these patients, using noninvasive or 
tracheostomy ventilation. Design: Retrospective cohort study. Methods: We 
report 33 patients with SMA true type I (onset before age 3 months), 35 
patients with SMA intermediate type I (onset between 3 months and 6 months), 
100 patients with SMA type II (onset between 6 months and 18 months), 12 
patients with SMA type III (onset after age 18 months). We report the 
clinical symptoms, respiratory course, and respiratory management: 
respiratory physiotherapy, periodic hyperinsufflation, nasal nocturnal 
ventilation (NNV), and tracheostomy. Also, we measured the FVC over several 
years during childhood and adolescence. Results: In patients with SMA true 
type I, 82% of patients died, one third of whom underwent tracheostomy. In 
patients with SMA intermediate type I, 43% needed NNV, 57% underwent 
tracheostomy, and 26% died. In patients with SMA type II, 38% needed NNV, 
15% underwent tracheostomy, and 4% died. In patients with SMA type III, 
respiratory impairment was moderate and began during the second decade of 
life. Conclusion: This data shows the progressively worsening course of 
restrictive respiratory insufficiency in patients with SMA, and the 
importance of early respiratory management to limit pulmonary complications 
and improve the quality of life for these patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Werdnig Hoffmann disease (etiology, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; artificial ventilation; aspiration pneumonia (complication); atelectasis (complication, therapy); breathing exercise; child; clinical feature; controlled study; disease course; dysphagia (complication); gastrostomy; human; infant; intermittent positive pressure ventilation; Kugelberg Welander disease (etiology, surgery, therapy); lung congestion (complication); major clinical study; mortality; nose breathing; priority journal; respiratory failure (etiology); retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004405037
MEDLINE PMID
  15364763 (http://www.ncbi.nlm.nih.gov/pubmed/15364763)
PUI
  L39258038
DOI
  10.1378/chest.126.3.831
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.126.3.831
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.126.3.831&atitle=Respiratory+capacity+course+in+patients+with+infantile+spinal+muscular+atrophy&stitle=Chest&title=Chest&volume=126&issue=3&spage=831&epage=837&aulast=Ioos&aufirst=Christine&auinit=C.&aufull=Ioos+C.&coden=CHETB&isbn=&pages=831-837&date=2004&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 901
TITLE
  Retro-pharyngeal obstruction in association with osteophytes of the cervical 
spine
AUTHOR NAMES
  Fuerderer S.; Eysel-Gosepath K.; Schröder U.; Delank K.-S.; Eysel P.
AUTHOR ADDRESSES
  (Fuerderer S.; Eysel-Gosepath K.; Delank K.-S.; Eysel P.) Dept. for 
Orthopaedic Surgery, Cologne University Hospitals, Joseph Stelzmannstrasse 
9, D-50931 Köln, Germany.
(Schröder U.) Department for ENT Surgery, Cologne University Hospitals, 
Joseph Stelzmannstrasse 9, D-50931 Köln, Germany.
CORRESPONDENCE ADDRESS
  S. Fuerderer, Dept. for Orthopaedic Surgery, Cologne University Hospitals, 
Joseph Stelzmannstrasse 9, D-50931 Köln, Germany.
FULL RECORD ENTRY DATE
  2004-09-16
SOURCE
  Journal of Bone and Joint Surgery - Series B (2004) 86:6 (837-840). Date of 
Publication: August 2004
VOLUME
  86
ISSUE
  6
FIRST PAGE
  837
LAST PAGE
  840
DATE OF PUBLICATION
  August 2004
ISSN
  0301-620X
BOOK PUBLISHER
  British Editorial Society of Bone and Joint Surgery, 22 Buckingham Street, 
London, United Kingdom.
ABSTRACT
  We describe five patients with cervical spondylosis and large anterior 
osteophytes causing pharyngeal compression. All had dysphagia, two had 
obstructive sleep apnoea and another two had dyspnoea and strider on 
inspiration. One, with perforation of the pharynx, required emergency 
tracheostomy. Only three had pain in the neck or arm. Compression of the 
retroglottic space was confirmed in all patients by pharyngoscopy and in all 
the symptoms were relieved by excision of the osteophytes. Three also 
underwent intervertebral fusion. One had some persistent sleep apnoea. © 
2004 British Editorial Society of Bone and Joint Surgery.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spondylosis (diagnosis, surgery); pharynx disease (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; clinical article; computer assisted tomography; decompression surgery; disease association; dyspnea; emergency surgery; female; gastrointestinal endoscopy; glottis; human; inspiratory capacity; male; neck pain; nuclear magnetic resonance imaging; osteophyte (diagnosis, surgery); pharynx examination; priority journal; sleep disordered breathing; spine fusion; spine surgery; stridor; symptom; tracheostomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Radiology (14)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004379798
MEDLINE PMID
  15330024 (http://www.ncbi.nlm.nih.gov/pubmed/15330024)
PUI
  L39173470
DOI
  10.1302/0301-620X.86B6.14933
FULL TEXT LINK
  http://dx.doi.org/10.1302/0301-620X.86B6.14933
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0301620X&id=doi:10.1302%2F0301-620X.86B6.14933&atitle=Retro-pharyngeal+obstruction+in+association+with+osteophytes+of+the+cervical+spine&stitle=J.+Bone+Jt.+Surg.+Ser.+B&title=Journal+of+Bone+and+Joint+Surgery+-+Series+B&volume=86&issue=6&spage=837&epage=840&aulast=Fuerderer&aufirst=S.&auinit=S.&aufull=Fuerderer+S.&coden=JBSUA&isbn=&pages=837-840&date=2004&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 902
TITLE
  Spinal anesthesia in a patient with Down's syndrome [2]
AUTHOR NAMES
  Schmitt H.J.
AUTHOR ADDRESSES
  (Schmitt H.J.)
FULL RECORD ENTRY DATE
  2004-07-19
SOURCE
  Canadian Journal of Anesthesia (2004) 51:6 (638). Date of Publication: 
June/July 2004
VOLUME
  51
ISSUE
  6
FIRST PAGE
  638
DATE OF PUBLICATION
  June/July 2004
ISSN
  0832-610X
BOOK PUBLISHER
  Canadian Anaesthetists' Society, 1 Eglinton Avenue East, Suite 208, Toronto, 
Canada.
EMTREE DRUG INDEX TERMS
  bupivacaine (adverse drug reaction, drug combination); clorazepate (oral drug administration); propofol (drug combination); Ringer lactate solution; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Down syndrome; spinal anesthesia; 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesiological procedure; atelectasis (side effect); case report; endotracheal intubation; human; letter; life history; male; oxygen saturation; premedication; priority journal; surgical technique; testis tumor (surgery); tracheostomy; 
CAS REGISTRY NUMBERS
  Ringer lactate solution (8022-63-7)
  bupivacaine (18010-40-7, 2180-92-9, 55750-21-5)
  clorazepate (20432-69-3, 23887-31-2)
  propofol (2078-54-8)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2004285732
MEDLINE PMID
  15197131 (http://www.ncbi.nlm.nih.gov/pubmed/15197131)
PUI
  L38867931
DOI
  10.1007/BF03018411
FULL TEXT LINK
  http://dx.doi.org/10.1007/BF03018411
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0832610X&id=doi:10.1007%2FBF03018411&atitle=Spinal+anesthesia+in+a+patient+with+Down%27s+syndrome+%5B2%5D&stitle=Can.+J.+Anesth.&title=Canadian+Journal+of+Anesthesia&volume=51&issue=6&spage=638&epage=&aulast=Schmitt&aufirst=Hubert+J.&auinit=H.J.&aufull=Schmitt+H.J.&coden=CJOAE&isbn=&pages=638-&date=2004&auinit1=H&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 903
TITLE
  Management of paraplegia
ORIGINAL (NON-ENGLISH) TITLE
  Management der querschnittlähmung (CME 4/04)
AUTHOR NAMES
  Büttner J.
AUTHOR ADDRESSES
  (Büttner J., buettner@bgu-murnau.de) Abteilung fur Anasthesiologie, 
Berufsgenossenschaft. Unfallklin., Prof.-Küntscher-Straße 8, D-82418 Murnau, 
Germany.
CORRESPONDENCE ADDRESS
  J. Büttner, Abteilung fur Anasthesiologie, Berufsgenossenschaft. 
Unfallklin., Prof.-Küntscher-Straße 8, D-82418 Murnau, Germany. Email: 
buettner@bgu-murnau.de
FULL RECORD ENTRY DATE
  2004-05-10
SOURCE
  Anasthesiologie und Intensivmedizin (2004) 45:4 (190-203). Date of 
Publication: April 2004
VOLUME
  45
ISSUE
  4
FIRST PAGE
  190
LAST PAGE
  203
DATE OF PUBLICATION
  April 2004
ISSN
  0170-5334
BOOK PUBLISHER
  DIOmed Verlags GmbH, Am Weichselgarten 30, Erlangen, Germany.
ABSTRACT
  In the case of a patient who is awake and communicative the neurologic 
examination of the senso-motor reflexes provides quick results in order to 
determine whether partial or total injury of the spinal cord has occurred. 
With a patient who is unconscious or whose level of consciousness is 
impaired the spine must be immobilized to prevent potential neural injury 
until a spinal injury has been excluded by means of a thorough diagnostic 
procedure in the hospital. To exclude a spinal injury, normal X-rays have to 
be taken in the lateral and anteroposterior view. A CT scan is mandatory if 
the spine, especially the lower cervical spine, cannot be visualized by 
means of a normal X-ray. An acute, total injury of the spinal cord causes 
immediate flaccid paralysis and loss of all sensation and reflex activity 
(including autonomic functions) below the level of injury (spinal shock). 
Patients with an acute, total cervical spinal cord injury show diaphragmatic 
respiration, bradycardia and hypotension. Patients who are unconscious 
and/or show signs of respiratory insufficiency require early intubation and 
assisted ventilation. In the case of emergency intubation, orotracheal 
intubation with inline manual cervical immobilization is indicated. 
Cardiovascular resuscitation mainly requires the application of crystalloids 
and colloids; if hypotension persists, dobutamin must be added. It is 
debatable whether a high dose of methylprednisolone applied initially during 
the acute phase gives better results in relation to the spinal cord lesion. 
Patients who sustain acute traumatic injuries of the cervical spine with 
associated neurologic deficit may benefit from immediate surgical 
decompression and stabilization. Patients with a total lesion between the C4 
and C6 levels will almost always show hypoventilation. All these patients 
need an artificial airway for a longer period and, for that reason, a 
tracheotomy should be performed early on. After days or weeks, the flaccid 
paralysis changes to spastic paraplegia due to exaggeration of the normal 
stretch reflexes. Muscle spasms occur and autonomic reflexes return. With 
the return of the spinal reflexes, precautions must be taken to prevent 
autonomic dysreflexia, a syndrome characterized by paroxysmal hypertension, 
bradycardia, sweating, facial flushing and headache. In severe cases 
cerebral haemorrhage and seizures may occur, precipitated by stimuli such as 
defecation or bladder distension. In the case of uro-genital procedures, 
especially cystoscopy, a general anaesthesia with an adequate depth or, 
better, a spinal anaesthesia has to be performed to prevent the onset of 
autonomic dysreflexia. Managing patients with paraplegia requires a staff of 
professional health-care workers familiar with the problems of spinal cord 
injury. For this reason, patients with spinal cord lesion should be 
transferred as soon as possible to a centre specialising in this kind of 
injury.
EMTREE DRUG INDEX TERMS
  dobutamine (drug therapy); methylprednisolone (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  paraplegia (diagnosis, drug therapy, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  anesthesia level; artificial ventilation; assisted ventilation; autonomic dysreflexia (complication); bladder distension; bradycardia (complication); brain hemorrhage; breathing pattern; colloid; computer assisted tomography; crystalloid; cystoscopy; decompression surgery; defecation; diaphragm; emergency treatment; flushing; headache (complication); human; hypertension (complication); hypotension (complication, drug therapy); hypoventilation; intensive care; medical decision making; neurologic examination; patient care; resuscitation; review; spinal cord injury (diagnosis, drug therapy, surgery, therapy); sweating; treatment planning; 
CAS REGISTRY NUMBERS
  dobutamine (34368-04-2, 52663-81-7)
  methylprednisolone (6923-42-8, 83-43-2)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  2004176839
PUI
  L38508193
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01705334&id=doi:&atitle=Management+of+paraplegia&stitle=Anasthesiol.+Intensivmed.&title=Anasthesiologie+und+Intensivmedizin&volume=45&issue=4&spage=190&epage=203&aulast=B%C3%BCttner&aufirst=Johannes&auinit=J.&aufull=B%C3%BCttner+J.&coden=ANIMD&isbn=&pages=190-203&date=2004&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2011 Elsevier B.V., All rights reserved.

RECORD 904
TITLE
  Anesthetic implication for brachytherapy for head and neck cancer patients
AUTHOR NAMES
  Sanghavi P.R.; Joshi G.; Patel B.M.; Dave C.R.; Shah R.A.
AUTHOR ADDRESSES
  (Sanghavi P.R.; Joshi G.; Patel B.M.; Dave C.R.; Shah R.A.) Department of 
Anaesthesia, Gujarat Cancer and Research Institute, Ahmedabad (Gujarat), 
India.
CORRESPONDENCE ADDRESS
  P.R. Sanghavi, Department of Anaesthesia, Gujarat Cancer and Research 
Institute, Ahmedabad (Gujarat), India.
FULL RECORD ENTRY DATE
  2005-07-05
SOURCE
  Journal of Anaesthesiology Clinical Pharmacology (2004) 20:2 (147-151). Date 
of Publication: Apr 2004
VOLUME
  20
ISSUE
  2
FIRST PAGE
  147
LAST PAGE
  151
DATE OF PUBLICATION
  Apr 2004
ISSN
  0970-9185
ABSTRACT
  This study includes 20 patients of head and neck cancer requiring anesthesia 
for brachytherapy implant. Our aim of study was to assess the problems 
associated with anesthetic management of such patients. On preoperative 
assessment, it was found that 35% of patients were cachexic, 35% patients 
had associated illness like hypertension, diabetes. 95% of patients had 
received previous radiotherapy, 10% patients were given chemotherapy and 5% 
of patients were subjected to surgery during course of their disease. 19 
patients were given general anesthesia and one patient was managed under 
monitored anesthesia. Preoperative tracheostomy was done in six patients. 
Airway was managed by fiberoptic intubation in one patient Nasogastric tube 
is must prior to implant Removal of implant also required general anesthesia 
in ten patients. None of patients had procedure related complications like 
bleeding, cervical spine injury due to hyperextension of neck and aspiration 
of blood or secretions in postoperative period. Only two patients (10%) had 
severe mucosal reaction due to radiation and required treatment Airway 
management and prevention of aspiration plays the vital role in management 
of these patients.
EMTREE DRUG INDEX TERMS
  dexamethasone; diclofenac; halothane; nitrous oxide; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; brachytherapy; head cancer (radiotherapy, surgery); neck cancer (radiotherapy, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; airway; article; aspiration; bleeding (complication); cachexia; cancer chemotherapy; cancer surgery; cervical spine injury (complication); clinical article; comorbidity; device removal; diabetes mellitus; female; general anesthesia; human; hypertension; intubation; male; mucosa inflammation (complication); nasogastric tube; patient monitoring; preoperative evaluation; tracheotomy; 
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
  diclofenac (15307-79-6, 15307-86-5)
  halothane (151-67-7, 66524-48-9)
  nitrous oxide (10024-97-2)
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Radiology (14)
  Cancer (16)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2005272797
PUI
  L40839248
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09709185&id=doi:&atitle=Anesthetic+implication+for+brachytherapy+for+head+and+neck+cancer+patients&stitle=J.+Anaesthesiol.+Clin.+Pharmacol.&title=Journal+of+Anaesthesiology+Clinical+Pharmacology&volume=20&issue=2&spage=147&epage=151&aulast=Sanghavi&aufirst=Priti+R.&auinit=P.R.&aufull=Sanghavi+P.R.&coden=JAPHF&isbn=&pages=147-151&date=2004&auinit1=P&auinitm=R
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 905
TITLE
  Outcome of Pediatric Patients with Severe Restrictive Lung Disease Following 
Reconstructive Spine Surgery
AUTHOR NAMES
  Wazeka A.N.; DiMaio M.F.; Boachie-Adjei O.
AUTHOR ADDRESSES
  (Wazeka A.N.; DiMaio M.F.) Department of Pediatrics, New York Presbyterian 
Hospital, Cornell University, New York, NY, United States.
(Boachie-Adjei O., boachie@hss.edu) Department of Orthopaedics, Hospital for 
Special Surgery, New York, NY, United States.
(Wazeka A.N.) Children's Medical Center, Morristown, NJ, United States.
(Boachie-Adjei O., boachie@hss.edu) Hospital for Special Surgery, 523 East 
72nd Street, New York, NY 10021, United States.
CORRESPONDENCE ADDRESS
  O. Boachie-Adjei, Hospital for Special Surgery, 523 East 72nd Street, New 
York, NY 10021, United States. Email: boachie@hss.edu
FULL RECORD ENTRY DATE
  2004-03-26
SOURCE
  Spine (2004) 29:5 (528-534). Date of Publication: 1 Mar 2004
VOLUME
  29
ISSUE
  5
FIRST PAGE
  528
LAST PAGE
  534
DATE OF PUBLICATION
  1 Mar 2004
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Study Design. Retrospective chart review. Objectives. To assess outcome and 
complications in pediatric patients with a vital capacity ≤45% of predicted 
who underwent reconstructive spine surgery for severe thoracic scoliosis. 
Summary of Background Data. Despite the known sequelae of untreated spine 
deformity, pediatric patients with severe restrictive lung disease are 
frequently not considered good operative candidates for surgical treatment 
on the basis of their underlying lung disease. Only a few reports have 
examined surgical treatment in this population Methods. A retrospective 
chart review was conducted on 21 pediatric patients with restrictive lung 
disease (average age 11.5 years, range 2-21 years). Eighteen patients 
completed pulmonary function testing, all with vital capacity ≤45%. The 
remaining three patients had clinical features of restrictive lung disease 
but could not perform pulmonary function testing. Eighteen patients 
underwent combined anterior and posterior spinal fusions. Before surgery, 
all patients were seen by the pulmonary, cardiology, pediatric, and 
anesthesia services, as well as neurology and gastroenterology services if 
indicated. Outcome variables examined were as follows: 1) days on oxygen, 2) 
need for tracheostomy, 3) days on ventilatory support, 4) mortality rate, 5) 
pulmonary complications, 6) blood loss, 7) other complications relative to 
the surgical procedure, and 8) length of stay. Results. For the 21 patients, 
the preoperative average vital capacity was 32% predicted (range 18-43%). 
After surgery, the median time on supplemental oxygen was 3 days (range 0-90 
days). Only one patient with a vital capacity of 29%, who was successfully 
extubated on postoperative day 4, developed a deep wound infection, which 
required incision and drainage, as well as recurrent right lung collapse, 
and subsequently required a tracheostomy to facilitate ventilator weaning. 
Four patients were on assisted ventilation before the surgery and continued 
to require it after surgery. Two additional patients required noninvasive 
positive pressure ventilation for a short period of time following the 
surgery. Pneumonia occurred in two patients, and pleural effusion occurred 
in two patients. Four patients developed postoperative atelectasis. There 
was one reoperation for implant failure. There were no mortalities or 
adverse neurologic outcomes. Major thoracic scoliosis measured an average of 
82° (range 40-140°) before surgery, with correction to an average of 35° 
(range 6-75°). Conclusions. Reconstructive spine surgery in pediatric 
patients with severe restrictive lung disease and significant spinal 
deformity is well tolerated. Familiarity with different surgical techniques 
of salvage reconstruction and perioperative multidisciplinary management 
should be emphasized. Routine preoperative tracheostomy is not indicated.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lung disease; restrictive lung disease; scoliosis (surgery); spine fusion; 
EMTREE MEDICAL INDEX TERMS
  adult; assisted ventilation; atelectasis (complication); bleeding; child; clinical article; female; human; length of stay; lung function test; male; mortality; oxygen therapy; pleura effusion (complication); pneumonia (complication); positive end expiratory pressure; postoperative complication; priority journal; review; spine surgery; surgical technique; tracheostomy; vital capacity; wound infection (complication); 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004104501
MEDLINE PMID
  15129066 (http://www.ncbi.nlm.nih.gov/pubmed/15129066)
PUI
  L38282610
DOI
  10.1097/01.BRS.0000103344.25246.64
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.BRS.0000103344.25246.64
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2F01.BRS.0000103344.25246.64&atitle=Outcome+of+Pediatric+Patients+with+Severe+Restrictive+Lung+Disease+Following+Reconstructive+Spine+Surgery&stitle=Spine&title=Spine&volume=29&issue=5&spage=528&epage=534&aulast=Wazeka&aufirst=April+N.&auinit=A.N.&aufull=Wazeka+A.N.&coden=SPIND&isbn=&pages=528-534&date=2004&auinit1=A&auinitm=N
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 906
TITLE
  Cervical spinal cord injury and deglutition disorders
AUTHOR NAMES
  Abel R.; Ruf S.; Spahn B.
AUTHOR ADDRESSES
  (Abel R., rainer.abel@ok.uni-heidelberg.de; Ruf S.; Spahn B.) Dept. of 
Orthoped. Surg. and Rehab., Orthopadische Univ. Klin. Heidelberg, 
Heidelberg, Germany.
(Abel R., rainer.abel@ok.uni-heidelberg.de) Orthoped. Univ. Hospital 
Heidelberg, Schlierbacher Landstraße 200, D-69118 Heidelberg, Germany.
CORRESPONDENCE ADDRESS
  R. Abel, Orthoped. Univ. Hospital Heidelberg, Schlierbacher Landstraße 200, 
D-69118 Heidelberg, Germany. Email: rainer.abel@ok.uni-heidelberg.de
FULL RECORD ENTRY DATE
  2004-07-11
SOURCE
  Dysphagia (2004) 19:2 (87-94). Date of Publication: Spring 2004
VOLUME
  19
ISSUE
  2
FIRST PAGE
  87
LAST PAGE
  94
DATE OF PUBLICATION
  Spring 2004
ISSN
  0179-051X
BOOK PUBLISHER
  Springer New York LLC, 233 Springer Street, New York, United States.
ABSTRACT
  The association of cervical spinal cord injury and swallowing disorders is 
clinically well recognized. This study was performed to determine the 
clinical significance and the outcome of deglutition disorders observed in 
the initial treatment of cervical spinal cord injury in our tertiary care 
spinal cord injury unit. All patients with cervical spinal cord injury 
admitted to our facility for initial care between January 1997 and December 
2000 were included in our study. Prevalence of dysphagia and frequency of 
pneumonia were determined. An assessment of deglutition at discharge was 
performed. Dysphagia was diagnosed in 26 of the 73 patients with cervical 
spinal cord injury. Tracheostomy and duration of orotracheal intubation are 
associated with dysphagia. The disorder necessitated dietary restrictions in 
18 patients. Six of these patients had to be discharged with a percutaneous 
enterogastric feeding tube; seven had persistent problems not resulting in 
dietary restrictions. The incidence of late pneumonia was significantly 
increased with two associated deaths. Dysphagia is a serious complication 
associated with prolonged requirement for ventilatory support. Patients have 
to be monitored closely because the incidence of pneumonia is increased. 
While the situation improves for most patients, a significant number of 
patients need a percutaneous enterogastric feeding tube as a permanent 
solution.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (rehabilitation); dysphagia (complication, epidemiology); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; artificial ventilation; cause of death; child; controlled study; diet restriction; disease association; endotracheal intubation; enteric feeding; female; hospital discharge; human; incidence; infant; major clinical study; male; patient monitoring; pneumonia (epidemiology); prevalence; priority journal; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004268119
MEDLINE PMID
  15382796 (http://www.ncbi.nlm.nih.gov/pubmed/15382796)
PUI
  L38808333
DOI
  10.1007/s00455-003-0511-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00455-003-0511-y
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0179051X&id=doi:10.1007%2Fs00455-003-0511-y&atitle=Cervical+spinal+cord+injury+and+deglutition+disorders&stitle=Dysphagia&title=Dysphagia&volume=19&issue=2&spage=87&epage=94&aulast=Abel&aufirst=Rainer&auinit=R.&aufull=Abel+R.&coden=DYSPE&isbn=&pages=87-94&date=2004&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 907
TITLE
  Thoraco-abdominal aneurysms of type IV
ORIGINAL (NON-ENGLISH) TITLE
  Aneurismi toraco-addominali di IV tipo.
AUTHOR NAMES
  Stella A.; Paragona O.; Freyrie A.; Faggioli G.; Kapelj S.; Spagnolo C.; Di Nino G.; D'Addato M.
AUTHOR ADDRESSES
  (Stella A.; Paragona O.; Freyrie A.; Faggioli G.; Kapelj S.; Spagnolo C.; Di 
Nino G.; D'Addato M.) Dipartimento di Scienze Chirurgiche e 
Anestestiologiche, Università di Bologna, Servizio di Chirurgia Vascolare.
CORRESPONDENCE ADDRESS
  A. Stella, Dipartimento di Scienze Chirurgiche e Anestestiologiche, 
Università di Bologna, Servizio di Chirurgia Vascolare.
FULL RECORD ENTRY DATE
  2004-11-05
SOURCE
  Annali italiani di chirurgia (2004) 75:2 (223-229). Date of Publication: 
2004 Mar-Apr
VOLUME
  75
ISSUE
  2
FIRST PAGE
  223
LAST PAGE
  229
DATE OF PUBLICATION
  2004 Mar-Apr
ISSN
  0003-469X
ABSTRACT
  AIM OF THE STUDY: Aims of the study were: 1. to evaluate the results of 
surgical treatment of type IV thoraco-abdominal aneurysms (TAA), with 
relationship to other types, 2. to evaluate results obtained with an 
approach different from the traditional thoraco-phreno laparatomy, with 
specific attention to postoperative respiratory function. MATERIAL AND 
METHODS: We have retrospectively compared type IV TAA with all other types 
of thoraco-abdominal aneurysms electively treated between January 1st, 1994 
and May 31st, 2003. Data on perioperative mortality, spinal cord ischemia 
and renal failure (both temporary and permanent) occurring in the first 30 
postoperative days were considered. Protection from spinal cord ischemia was 
accomplished through liquor drainage and prostaglandin E1 (PGE1) infusion. 
When the aneurysm extension was limited to the celiac axis an extrapleuric 
access with removal of XI rib was performed. In this subgroup of patients we 
have considered postoperative recovery time of respiratory function 
(intubation time, number of days in intensive care unit, postoperative 
pulmonary complications) postoperative renal failure, perioperative 
mortality and morbidity. RESULTS: Seventy-eight TAA have been treated in the 
period of time of the study. Twenty cases were type IV TAA (25.6%) of which 
2 due to chronic dissection. Cumulative postoperative mortality has been 
19.2%. The single perioperative death in the group of type IV TAA (5%) 
occurred in post-operative day 15 for multiple organ failure. No spinal cord 
ischemia occurred in this group. Temporary renal failure occurred in 3 cases 
(15%) with one case requiring dialysis. In 10 cases (50%) an extrapleuric 
access with removal of XI rib was performed, with adequate control of the 
proximal aorta. Postoperative respiratory failure requiring and intubation 
time longer than 12 hours occurred in 2 cases (20%). In the remaining 8 
cases the mean intubation time was 5.3 hours (range 4-8 hrs). Tracheostomy 
was not necessary in any case. Mean time of intensive care unit stay was 3.5 
days (range 0-15 days). CONCLUSION: The appropriate treatment of type IV TAA 
leads to low mortality and morbidity with results similar to those of 
pararenal aneurysms rather than those of other TAA forms. Left extrapleuric 
access when feasible allows faster recovery of a normal respiratory 
function.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aortic aneurysm (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; classification; female; human; male; methodology; middle aged; retrospective study; vascular surgery; 
LANGUAGE OF ARTICLE
  Italian
MEDLINE PMID
  15386994 (http://www.ncbi.nlm.nih.gov/pubmed/15386994)
PUI
  L39412520
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0003469X&id=doi:&atitle=Thoraco-abdominal+aneurysms+of+type+IV&stitle=Ann+Ital+Chir&title=Annali+italiani+di+chirurgia&volume=75&issue=2&spage=223&epage=229&aulast=Stella&aufirst=A.&auinit=A.&aufull=Stella+A.&coden=&isbn=&pages=223-229&date=2004&auinit1=A&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 908
TITLE
  Tracheostomy placement in patients with complete cervical spinal cord 
injuries: American Spinal Injury Association Grade A
AUTHOR NAMES
  Harrop J.S.; Sharan A.D.; Scheid Jr. E.H.; Vaccaro A.R.; Przybylski G.J.
AUTHOR ADDRESSES
  (Harrop J.S., James.Harrop@jefferson.edu) Department of Neurosurgery, 909 
Walnut Street, Philadelphia, PA 19107, United States.
(Sharan A.D.; Scheid Jr. E.H.; Vaccaro A.R.; Przybylski G.J.)
CORRESPONDENCE ADDRESS
  J.S. Harrop, Department of Neurosurgery, 909 Walnut Street, Philadelphia, PA 
19107, United States. Email: James.Harrop@jefferson.edu
FULL RECORD ENTRY DATE
  2004-01-19
SOURCE
  Journal of Neurosurgery (2004) 100:1 SUPPL. (20-23). Date of Publication: 
January 2004
VOLUME
  100
ISSUE
  1 SUPPL.
FIRST PAGE
  20
LAST PAGE
  23
DATE OF PUBLICATION
  January 2004
ISSN
  0022-3085
BOOK PUBLISHER
  American Association of Neurological Surgeons, 1224 West Main Street Suite 
450, Charlottesville, United States.
ABSTRACT
  Object. The authors sought to identify variables that predispose patients 
with acute American Spinal Injury Association (ASIA) Grade A cervical spinal 
cord injury (SCI) to require tracheostomies for ventilator support or airway 
protection. Methods. A retrospective analysis was performed of 178 
consecutive patients with a cervical ASIA Grade A SCI who were admitted 
through the Delaware Valley SCI Center at Thomas Jefferson Hospital during a 
6-year period. Exclusion criteria included injury occurring more than 48 
hours prior to admission, death within 14 days of admission or nontraumatic 
SCI. Twenty-two patients were excluded based on these criteria. Parameters 
evaluated in the remaining population (156 patients) included demographics, 
cervical vertebral ASIA level, tracheostomy placement, pneumonia, premorbid 
pulmonary disease, smoking history, evidence of direct thoracic/lung trauma, 
operative intervention, associated appendicular trauma, and preexisting 
medical comorbidities. The ASIA classification of the 156 patients included 
in this analysis were C-2 (eight), C-3 (11), C-4 (64), C-5 (36), C-6 (20), 
C-7 (13), and C-8 (four). Tracheostomies were performed in 107 of these 156 
patients. Statistical analysis revealed a significant relationship between 
tracheostomy and patient age (p = 0.0048), preexisting medical conditions (p 
= 0.0417), premorbid lung disease (p = 0.0177), higher cervical ASIA level 
(p < 0.0001), and the presence of pneumonia (p < 0.0001). No patient with a 
C-8 ASIA A injury required tracheostomy, whereas all C-2 and C-3 ASIA 
A-injured patients underwent tracheostomies. Patients older than 45 years of 
age with ASIA A levels between C-4 and C-7 more commonly required 
tracheostomy (p < 0.005) than patients younger than 45 years of age. 
Conclusions. Several risk factors were identified that corresponded to the 
frequent tracheostomy placement in the acute injury phase after complete 
cervical SCI. Early tracheostomy may be considered in patients with multiple 
risk factors to reduce duration of stay in the intensive care unit and 
facilitate ventilatory weaning.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; comorbidity; demography; disease classification; disease predisposition; female; human; intensive care unit; lung disease; lung injury; major clinical study; male; medical society; pneumonia; priority journal; risk factor; smoking; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004003282
MEDLINE PMID
  14748569 (http://www.ncbi.nlm.nih.gov/pubmed/14748569)
PUI
  L38010004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223085&id=doi:&atitle=Tracheostomy+placement+in+patients+with+complete+cervical+spinal+cord+injuries%3A+American+Spinal+Injury+Association+Grade+A&stitle=J.+Neurosurg.&title=Journal+of+Neurosurgery&volume=100&issue=1+SUPPL.&spage=20&epage=23&aulast=Harrop&aufirst=James+S.&auinit=J.S.&aufull=Harrop+J.S.&coden=JONSA&isbn=&pages=20-23&date=2004&auinit1=J&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 909
TITLE
  Diaphragmatic Pacing in Neuromuscular Respiratory Failure
AUTHOR NAMES
  García-Morato J.; De Vito E.L.
AUTHOR ADDRESSES
  (García-Morato J., jmorato@intramed.net.ar) Departamento de Cirugía, 
Hospital de Clínicas, Universidad de Buenos Aires, .
(De Vito E.L.) Jefe del Laboratorio Pulmonar, Instituto de Investigaciones 
Medicas, Universidad de Buenos Aires, .
(García-Morato J., jmorato@intramed.net.ar) Marcelo T. de Alvear 2400 3, CP 
1122 Buenos Aires, Argentina.
CORRESPONDENCE ADDRESS
  J. García-Morato, Marcelo T. de Alvear 2400 3, CP 1122 Buenos Aires, 
Argentina. Email: jmorato@intramed.net.ar
FULL RECORD ENTRY DATE
  2004-02-05
SOURCE
  Clinical Pulmonary Medicine (2004) 11:1 (25-32). Date of Publication: Jan 
2004
VOLUME
  11
ISSUE
  1
FIRST PAGE
  25
LAST PAGE
  32
DATE OF PUBLICATION
  Jan 2004
ISSN
  1068-0640
ABSTRACT
  Electrical activation of the diaphragm is a technology that allows the 
treatment of selected forms of respiratory failure. The diaphragmatic pacing 
is carried out by an implanted electrode and receiver with a pocket or 
tabletop external transmitter. The device electrically stimulates the 
phrenic nerves to contract the diaphragm rhythmically. The main indication 
for diaphragm pacing is for ventilator-dependent subjects after high 
cervical cord injury and patients with central alveolar hypoventilation. The 
clinical requirements are stable clinical condition and intact phrenic 
nerves, diaphragms, and lungs. In most patients, a training period is 
required to provoke a gradual conditioning effect, improving endurance to 
diaphragmatic fatigue. A cooperative patient, supportive family and friends, 
and a skilled care team are paramount conditions. Diaphragmatic pacing 
probably does not lengthen life, but it can increase the quality of life. 
Tracheostomy is usually required to overcome upper airway obstruction. Poor 
results are related to inadequate selection of patients, complications 
related to implantation, system failure, inappropriate pacing schedule, 
inadequate follow-up, or lack of patient compliance or family support. The 
long-term results of diaphragm pacing demonstrate its usefulness both in 
adult and pediatric patients when applied in the correct circumstances.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  central alveolar hypoventilation (therapy); diaphragmatic pacing; hypoventilation (therapy); nerve stimulation; phrenic nerve; respiratory failure (therapy); 
EMTREE MEDICAL INDEX TERMS
  cervical spinal cord injury (therapy); diaphragm disease; electrode; follow up; human; motor neuron disease; muscle fatigue; patient compliance; patient selection; preoperative evaluation; quality of life; review; tracheostomy; treatment contraindication; treatment indication; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2004039635
PUI
  L38112282
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10680640&id=doi:&atitle=Diaphragmatic+Pacing+in+Neuromuscular+Respiratory+Failure&stitle=Clin.+Pulm.+Med.&title=Clinical+Pulmonary+Medicine&volume=11&issue=1&spage=25&epage=32&aulast=Garc%C3%ADa-Morato&aufirst=Joaqu%C3%ADn&auinit=J.&aufull=Garc%C3%ADa-Morato+J.&coden=CPMEF&isbn=&pages=25-32&date=2004&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 910
TITLE
  Caesarean section in a parturient with type III spinal muscular atrophy and 
pre-eclampsia
AUTHOR NAMES
  Kitson R.; Williams V.; Howell C.
AUTHOR ADDRESSES
  (Kitson R., ross.kitson@nstaffsh.wmids.nhs.uk; Williams V.; Howell C.) City 
General Hospital, Stoke-on-Trent, United Kingdom.
CORRESPONDENCE ADDRESS
  R. Kitson, City General Hospital, Stoke-on-Trent, United Kingdom. Email: 
ross.kitson@nstaffsh.wmids.nhs.uk
FULL RECORD ENTRY DATE
  2004-01-27
SOURCE
  Anaesthesia (2004) 59:1 (94-95). Date of Publication: January 2004
VOLUME
  59
ISSUE
  1
FIRST PAGE
  94
LAST PAGE
  95
DATE OF PUBLICATION
  January 2004
ISSN
  0003-2409
BOOK PUBLISHER
  Blackwell Publishing Ltd, 9600 Garsington Road, Oxford, United Kingdom.
EMTREE DRUG INDEX TERMS
  alfentanil (drug combination); diclofenac (drug therapy, rectal drug administration); hydralazine (drug therapy); isoflurane (drug combination); lidocaine (drug combination, topical drug administration); morphine (drug therapy, intravenous drug administration); nitrous oxide (drug combination); oxygen (drug combination); phenylephrine (drug combination, topical drug administration); propofol (drug combination); steroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cesarean section; Kugelberg Welander disease; preeclampsia (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; anesthesia induction; case report; collapse; disease classification; female; human; hypertension (drug therapy); kyphoscoliosis; labor; letter; positive end expiratory pressure; postoperative pain (drug therapy); pregnancy; topical anesthesia; tracheostomy; 
CAS REGISTRY NUMBERS
  alfentanil (69049-06-5, 71195-58-9)
  diclofenac (15307-79-6, 15307-86-5)
  hydralazine (304-20-1, 86-54-4)
  isoflurane (26675-46-7)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  morphine (52-26-6, 57-27-2)
  nitrous oxide (10024-97-2)
  oxygen (7782-44-7)
  phenylephrine (532-38-7, 59-42-7, 61-76-7)
  propofol (2078-54-8)
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2004026886
MEDLINE PMID
  14687114 (http://www.ncbi.nlm.nih.gov/pubmed/14687114)
PUI
  L38075622
DOI
  10.1111/j.1365-2044.2004.03593.x
FULL TEXT LINK
  http://dx.doi.org/10.1111/j.1365-2044.2004.03593.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032409&id=doi:10.1111%2Fj.1365-2044.2004.03593.x&atitle=Caesarean+section+in+a+parturient+with+type+III+spinal+muscular+atrophy+and+pre-eclampsia&stitle=Anaesthesia&title=Anaesthesia&volume=59&issue=1&spage=94&epage=95&aulast=Kitson&aufirst=Ross&auinit=R.&aufull=Kitson+R.&coden=ANASA&isbn=&pages=94-95&date=2004&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 911
TITLE
  Review of pediatric patients subjected to tracheotomy in Aragon, La Rioja 
and Soria, Spain, between 1988 and 2000
ORIGINAL (NON-ENGLISH) TITLE
  Revisión de los pacientes pediátricos sometidos a traqueotomía en Aragón, La 
Rioja y Soria. Periodo 1988-2000
AUTHOR NAMES
  Medrano Marina P.; Ruiz Escusol S.; Galván Manso M.; Muñoz Albillos M.S.; Rebage Moisés V.; López Pisón J.
AUTHOR ADDRESSES
  (Medrano Marina P.; Ruiz Escusol S.; Galván Manso M.; López Pisón J., 
jlopezpi@salud.aragob.es) Seccion UCI y Neuropediatria, Hospital Infantil 
Miguel Servet, Zaragoza, Spain.
(Rebage Moisés V.) Sección Neonatal, Hospital Infantil Miguel Servet, 
Zaragoza, Spain.
(Muñoz Albillos M.S.) Sección de Pediatría, Hospital Obispo Polanco, Teruel, 
Spain.
CORRESPONDENCE ADDRESS
  P. Medrano Marina, Seccion UCI y Neuropediatria, Hospital Infantil Miguel 
Servet, Zaragoza, Spain.
FULL RECORD ENTRY DATE
  2004-02-13
SOURCE
  Acta Pediatrica Espanola (2003) 61:11 (595-600). Date of Publication: Dec 
2003
VOLUME
  61
ISSUE
  11
FIRST PAGE
  595
LAST PAGE
  600
DATE OF PUBLICATION
  Dec 2003
ISSN
  0001-6640
ABSTRACT
  Introduction and objective: Advances in medical knowledge and technology, as 
well as the broadening of ethical criteria in order to improve the life 
quality of patients with chronic diseases generates new treatment demands, 
among them, improved respiratory function. The review of pediatric patients 
tracheotomized in recent years will help us to know the current situation 
and establish a comparative reference for the future. Patients and methods: 
The diagnoses in pediatric patients from Aragon, La Rioja and Soria, Spain, 
tracheotomized between January 1988 and December 2000, were reviewed. 
Results: Tracheotomy was performed in 17 patients. There were 5 emergency 
interventions: two cases of acute laryngotracheitis, two children with 
Down's syndrome (one with chronic lung disease and other with congenital 
heart disease) and one case of merosin-deficient congenital muscular 
dystrophy. The operation was elective on 12 occasions: one case of Pierre 
Robin syndrome, two infants with prenatal involvement of cranial nerves, one 
case of severe prenatal encephalopathy, one case of encephalopathy as a 
consequence of near-drowning, one malformation of the craniocervical 
junction with involvement of the spino-bulbar junction, one case of C1-C2 
spinal cord trauma, one case of cervicomediastinal lymphangioma, one 
metabolic disorder with leukodystrophy and peripheral polyneuropathy, one 
case of severe mitochondrial encephalopathy, one case of severe infantile 
mitochondrial myopathy, and a Chiari II malformation. Comments: A 
neurological disorder at any level of the central nervous system or the 
neuromuscular junction may be an indication for tracheotomy.
EMTREE DRUG INDEX TERMS
  merosin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  pediatrics; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; Arnold Chiari malformation; assisted ventilation; cervical spinal cord; child; chronic respiratory failure (therapy); clinical article; Down syndrome; ethics; female; human; laryngotracheobronchitis (therapy); male; muscular dystrophy (congenital disorder, therapy); neurologic disease; Pierre Robin syndrome; polyneuropathy; quality of life; respiratory function; review; Spain; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Pediatrics and Pediatric Surgery (7)
  Surgery (9)
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  English, Spanish
EMBASE ACCESSION NUMBER
  2004053820
PUI
  L38146028
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016640&id=doi:&atitle=Review+of+pediatric+patients+subjected+to+tracheotomy+in+Aragon%2C+La+Rioja+and+Soria%2C+Spain%2C+between+1988+and+2000&stitle=Acta+Pediatr.+Esp.&title=Acta+Pediatrica+Espanola&volume=61&issue=11&spage=595&epage=600&aulast=Medrano+Marina&aufirst=P.&auinit=P.&aufull=Medrano+Marina+P.&coden=APESA&isbn=&pages=595-600&date=2003&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 912
TITLE
  Is primary repair of esophageal perforation a safe method of management in 
case of patients with delayed diagnosis?
ORIGINAL (NON-ENGLISH) TITLE
  Czy pierwotna naprawa rozpoznanych z opóźnieniem uszkodzeń przełyku jest 
postȩpowaniem bezpiecznym?
AUTHOR NAMES
  Rokicki M.; Rokicki W.; Wallner G.
AUTHOR ADDRESSES
  (Wallner G.) Krenowick II Katedra, Klinika Chirurgii Ogolnej, AM, Lublin, 
Poland.
(Rokicki M.; Rokicki W.)
CORRESPONDENCE ADDRESS
  Krenowick II Katedra, Klinika Chirurgii Ogolnej, AM, Lublin, Poland.
FULL RECORD ENTRY DATE
  2004-01-05
SOURCE
  Polski Przeglad Chirurgiczny (2003) 75:12 (1197-1206). Date of Publication: 
2003
VOLUME
  75
ISSUE
  12
FIRST PAGE
  1197
LAST PAGE
  1206
DATE OF PUBLICATION
  2003
ISSN
  0032-373X
ABSTRACT
  Aim of the study was to determine whether primary surgical repair of 
esophageal perforation is effective when peformed after delayed diagnosis. 
Material and methods. The study group comprised 10 patients treated during 
the period between 1994 and 2000 due to esophageal perforation after delayed 
diagnosis. Perforation was caused by a foreign object in six cases, 
spontaneous esophageal rupture (Boerhaave's syndrome) in three, and cervical 
spine fracture on one. Predominant symptoms on admission, included 
mediastinitis, sepsis and endotoxic shock. Surgical management consisted in 
a two-layer suture closure of isolated and debrided esophageal edges, 
removal of fibrin and food residue form the lung, and extensive drainage of 
the mediastinum and pleural spaces. Eight patients required gastrostomy 
followed by pyloroplasty, seven received nutritional jejunostomy, while six 
underwent tracheostomy. Six patients required mechanical ventilation. 
Results. Six patients presented with postoperative complications, including 
three requiring reoperation. Remaining patients underwent conservative 
treatment, which proved successful. All patients survived. Conclusion. Our 
technique could be adapted individually to each case, enabling complete 
recovery of all patients who had been admitted to the hospital with delayed 
diagnosis of esophageal perforation. Moreover, management enabled to 
preserve the integrity of the esophagus. We believe that the above-mentioned 
method of treatment is quite safe.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus perforation (diagnosis, epidemiology, etiology, surgery); esophagus surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; artificial ventilation; Boerhaave syndrome (diagnosis, epidemiology, surgery); cervical spine fracture (diagnosis, epidemiology); clinical article; clinical feature; complication; conservative treatment; debridement; diagnostic error; esophagus reconstruction; female; foreign body; gastrostomy; human; jejunostomy; male; mediastinitis (complication, epidemiology); parenteral nutrition; postoperative complication; pyloroplasty; reoperation; sepsis (complication, epidemiology); septic shock (complication, epidemiology); surgical technique; survival; suture technique; thoracocentesis; tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Gastroenterology (48)
  Surgery (9)
LANGUAGE OF ARTICLE
  Polish, English
LANGUAGE OF SUMMARY
  English, Polish
EMBASE ACCESSION NUMBER
  2003513676
PUI
  L37541407
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0032373X&id=doi:&atitle=Is+primary+repair+of+esophageal+perforation+a+safe+method+of+management+in+case+of+patients+with+delayed+diagnosis%3F&stitle=Pol.+Prz.+Chir.&title=Polski+Przeglad+Chirurgiczny&volume=75&issue=12&spage=1197&epage=1206&aulast=Wallner&aufirst=Grzegorz&auinit=G.&aufull=Wallner+G.&coden=PPCHA&isbn=&pages=1197-1206&date=2003&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 913
TITLE
  Achondroplasia with respiratory failure
ORIGINAL (NON-ENGLISH) TITLE
  Ahondroplazija sa zatajenjem disanja
AUTHOR NAMES
  Omazić A.; Meštrović J.; Jurinović M.; Stričević L.; Polić B.; Lahman M.
AUTHOR ADDRESSES
  (Lahman M.) Klinička bolnica Split, Split, Croatia.
(Omazić A.) Jedinica Intenzivnog Lijecenja Djece, Klinika za Dječje Bolesti, 
Klinička Bolnica Split, Spinčićeva 1, 21000 Split, Croatia.
(Meštrović J.; Jurinović M.; Stričević L.; Polić B.)
CORRESPONDENCE ADDRESS
  A. Omazić, Jedinica Intenzivnog Lijecenja Djece, Klinika za Dječje Bolesti, 
Klinička Bolnica Split, Spinčićeva 1, 21000 Split, Croatia.
FULL RECORD ENTRY DATE
  2003-11-12
SOURCE
  Paediatria Croatica (2003) 47:3 (149-151). Date of Publication: 2003
VOLUME
  47
ISSUE
  3
FIRST PAGE
  149
LAST PAGE
  151
DATE OF PUBLICATION
  2003
ISSN
  1330-1403
ABSTRACT
  We have documented the case of a 3-year-old girl with achondroplasia, who 
was hospitalized in our clinic at the age of 14 months with bronchopneumonia 
and severe hypotonia. Breathing difficulties progressed to complete 
respiratory failure. She is now mechanically ventilated through a 
tracheostome. Computed tomography and magnetic resonance imaging showed 
narrowing of the foramen magnum and vertebrae at the level of the 
craniocervical junction with subsequent compression of the medulla. A 
suboccipital craniectomy and laminectomy of the atlas were carried out. 
Postoperatively the neurologic symptoms were slightly improved, but she had 
to be further mechanically ventilated. We wish to bring to attention the 
possibility of respiratory, failure caused by cervicomedullary compression 
in children with achondroplasia. We emphasize the importance of early 
diagnosis, the possibility of surgical intervention, and monitoring.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  achondroplasia (diagnosis); respiratory failure (etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; atlantooccipital joint; breathing disorder; bronchopneumonia; case report; cervical spine; clinical feature; computer assisted tomography; craniectomy; disease association; disease course; disease severity; early diagnosis; female; first cervical vertebra; foramen magnum; general condition improvement; hospitalization; human; laminectomy; monitoring; muscle hypotonia; neurologic disease; nuclear magnetic resonance imaging; postoperative period; preschool child; spinal cord compression (complication, diagnosis, etiology, surgery); tracheostomy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Serbian
LANGUAGE OF SUMMARY
  English, Serbian
EMBASE ACCESSION NUMBER
  2003442807
PUI
  L37345338
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13301403&id=doi:&atitle=Achondroplasia+with+respiratory+failure&stitle=Paediatr.+Croat.&title=Paediatria+Croatica&volume=47&issue=3&spage=149&epage=151&aulast=Lahman&aufirst=Maja&auinit=M.&aufull=Lahman+M.&coden=PCROE&isbn=&pages=149-151&date=2003&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 914
TITLE
  Removal of the tracheostomy tube in the aspirating spinal cord-injured 
patient
AUTHOR NAMES
  Ross J.; White M.
AUTHOR ADDRESSES
  (Ross J.) Physiotherapy Department, Austin Hospital, Melbourne, Vic., 
Australia.
(White M.) Speech Pathology Department, Austin Hospital, Melbourne, Vic., 
Australia.
(Ross J.) PO Box 1263, Kensington, NSW 3031, Australia.
CORRESPONDENCE ADDRESS
  J. Ross, PO Box 1263, Kensington, NSW 3031, Australia.
FULL RECORD ENTRY DATE
  2003-11-25
SOURCE
  Spinal Cord (2003) 41:11 (636-642). Date of Publication: November 2003
VOLUME
  41
ISSUE
  11
FIRST PAGE
  636
LAST PAGE
  642
DATE OF PUBLICATION
  November 2003
ISSN
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Four related case reports, occurring within a 10-month time 
frame during 2001. Objectives: Aspiration is commonly reported in the 
literature as a contraindication to decannulation. We report four examples 
of successful removal of the tracheostomy tube in the presence of aspiration 
by an experienced team, utilising a risk management approach. Setting: 
Victorian Spinal Cord Service (VSCS), Austin Hospital, Melbourne, Australia. 
Methods: Four individuals in our unit with traumatic spinal cord injury, 
three quadriplegic and one paraplegic, presented with aspiration identified 
by a positive modified Evan's blue dye test or constant coughing, gagging 
and oxygen desaturation during cuff deflation trials. In three of the four 
cases, the tracheostomy tube had been in situ for a prolonged period and the 
patients had failed to progress towards decannulation. A decision was made 
to decannulate these four patients in spite of the presence of traditionally 
held contraindications for decannulation. The multidisciplinary team 
carefully compared the inherent risks of premature decannulation against 
those of prolonged tracheostomisation. Given the risk associated with this 
procedure, a closely monitored decannulation protocol was instituted. 
Results: All four patients were successfully decannulated with improved 
quality of life, eating between 1 and 4 days and communicating immediately 
after decannulation. None experienced respiratory deterioration. Conclusion: 
It is possible to safely decannulate aspirating spinal cord injured 
individuals in some instances, using a risk management approach.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  aspiration pneumonia; spinal cord injury (disease management); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; case report; coughing; endotracheal tube; female; gastrointestinal symptom; human; male; oxygen saturation; paraplegia; priority journal; quadriplegia; quality of life; risk assessment; risk management; teamwork; treatment contraindication; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003459301
MEDLINE PMID
  14569265 (http://www.ncbi.nlm.nih.gov/pubmed/14569265)
PUI
  L37386449
DOI
  10.1038/sj.sc.3101510
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3101510
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3101510&atitle=Removal+of+the+tracheostomy+tube+in+the+aspirating+spinal+cord-injured+patient&stitle=Spinal+Cord&title=Spinal+Cord&volume=41&issue=11&spage=636&epage=642&aulast=Ross&aufirst=J.&auinit=J.&aufull=Ross+J.&coden=SPCOF&isbn=&pages=636-642&date=2003&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 915
TITLE
  Clinical Ventilator Adjustments That Improve Speech
AUTHOR NAMES
  Hoit J.D.; Banzett R.B.; Lohmeier H.L.; Hixon T.J.; Brown R.
AUTHOR ADDRESSES
  (Hoit J.D., hoit@email.arizona.edu; Lohmeier H.L.; Hixon T.J.) Dept. of 
Speech and Hearing Sciences, Natl. Ctr. Neurogenic Commun. D., University of 
Arizona, Tucson, AZ, United States.
(Banzett R.B.) Physiology Program, Harvard School of Public Health, Boston, 
MA, United States.
(Brown R.) Pulmonary Section, Vet. Admin. Boston Healthcare System, Boston, 
MA, United States.
(Banzett R.B.; Brown R.) Pulmonary and Critical Care Unit, Massachusetts 
General Hospital, Boston, MA, United States.
(Hoit J.D., hoit@email.arizona.edu) Dept. of Speech and Hearing Sciences, 
University of Arizona, PO Box 210071, Tucson, AZ 85721, United States.
CORRESPONDENCE ADDRESS
  J.D. Hoit, Dept. of Speech and Hearing Sciences, University of Arizona, PO 
Box 210071, Tucson, AZ 85721, United States. Email: hoit@email.arizona.edu
FULL RECORD ENTRY DATE
  2003-11-04
SOURCE
  Chest (2003) 124:4 (1512-1521). Date of Publication: October 2003
VOLUME
  124
ISSUE
  4
FIRST PAGE
  1512
LAST PAGE
  1521
DATE OF PUBLICATION
  October 2003
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Study objectives: We sought to improve speech in tracheostomized individuals 
receiving positive-pressure ventilation. Such individuals often speak with 
short phrases, long pauses, and have problems with loudness and voice 
quality. Subjects: We studied 15 adults with spinal cord injuries or 
neuromuscular diseases receiving long-term ventilation. Interventions: The 
ventilator was adjusted using lengthened inspiratory time (TI), positive 
end-expiratory pressure (PEEP), and combinations thereof. Results: When TI 
was lengthened (by 8 to 35% of the ventilator cycle), speaking time 
increased by 19% and pause time decreased by 12%. When PEEP was added (5 to 
10 cm H (2)O), speaking time was 25% longer and obligatory pauses were 21% 
shorter. When lengthened TI and PEEP were combined (with or without reduced 
tidal volume), their effects were additive, increasing speaking time by 55% 
and decreasing pause time by 36%. The combined intervention improved speech 
timing, loudness, voice quality, and articulation. Individual differences in 
subject response to the interventions were substantial in some cases. We 
also tested high PEEP (15 cm H(2)O) in three subjects and found speech to be 
essentially identical to that produced with a one-way valve. Conclusions: 
These simple interventions markedly improve ventilator-supported speech and 
are safe, at least when used on a short-term basis. High PEEP is a safer 
alternative than a one-way valve.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  positive end expiratory pressure; speech rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; artificial ventilation; clinical article; controlled study; female; human; inspiratory capacity; loudness; male; neuromuscular disease (therapy); priority journal; speech articulation; speech therapy; spinal cord injury (therapy); tidal volume; tracheostomy; ventilator; voice; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Arthritis and Rheumatism (31)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003424593
MEDLINE PMID
  14555587 (http://www.ncbi.nlm.nih.gov/pubmed/14555587)
PUI
  L37290065
DOI
  10.1378/chest.124.4.1512
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.124.4.1512
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.124.4.1512&atitle=Clinical+Ventilator+Adjustments+That+Improve+Speech&stitle=Chest&title=Chest&volume=124&issue=4&spage=1512&epage=1521&aulast=Hoit&aufirst=Jeannette+D.&auinit=J.D.&aufull=Hoit+J.D.&coden=CHETB&isbn=&pages=1512-1521&date=2003&auinit1=J&auinitm=D
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 916
TITLE
  Spinal fusion in patients with Duchenne's muscular dystrophy and a low 
forced vital capacity
AUTHOR NAMES
  Marsh A.; Edge G.; Lehovsky J.
AUTHOR ADDRESSES
  (Marsh A., Alastairmarsh@doctors.org.uk; Edge G.; Lehovsky J.) Royal 
National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, United 
Kingdom.
(Marsh A., Alastairmarsh@doctors.org.uk) 53 Upland Way, KT18 5SN Epsom, 
Surrey, United Kingdom.
CORRESPONDENCE ADDRESS
  A. Marsh, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, 
Middlesex, United Kingdom. Email: Alastairmarsh@doctors.org.uk
FULL RECORD ENTRY DATE
  2003-12-08
SOURCE
  European Spine Journal (2003) 12:5 (507-512). Date of Publication: October 
2003
VOLUME
  12
ISSUE
  5
FIRST PAGE
  507
LAST PAGE
  512
DATE OF PUBLICATION
  October 2003
ISSN
  0940-6719
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Traditionally, spinal fusion has been denied to patients with scoliosis 
secondary to Duchenne's muscular dystrophy (DMD) when their forced vital 
capacity (FVC) is less than 30-40% of predicted values (PFVC). The reasons 
for this decision are a theoretically increased risk of adverse events from 
a prolonged anaesthetic and extensive surgery. This paper presents a 
retrospective analysis of 30 patients with DMD scoliosis who underwent 
posterior spinal fusion at the Royal National Orthopaedic Hospital. Two 
subgroups of patients were compared: those with more than 30% PFVC (17 
patients) and those with less than 30% PVFC (13 patients). One patient in 
each group required a temporary tracheotomy and there were nine 
complications in total. The post-operative stay for patients in each group 
was similar (24 days in the >30% group, 20 days in the <30% group) and the 
complication rate was comparable with other published series. We conclude 
that spinal fusion can be offered to patients with DMD even in the presence 
of a low FVC.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Duchenne muscular dystrophy; forced expiratory volume; scoliosis (surgery); spine fusion; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; breathing muscle; child; clinical article; controlled study; human; postoperative complication (complication); priority journal; spine surgery; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003464983
MEDLINE PMID
  12748897 (http://www.ncbi.nlm.nih.gov/pubmed/12748897)
PUI
  L37409950
DOI
  10.1007/s00586-003-0545-8
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00586-003-0545-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09406719&id=doi:10.1007%2Fs00586-003-0545-8&atitle=Spinal+fusion+in+patients+with+Duchenne%27s+muscular+dystrophy+and+a+low+forced+vital+capacity&stitle=Eur.+Spine+J.&title=European+Spine+Journal&volume=12&issue=5&spage=507&epage=512&aulast=Marsh&aufirst=A.&auinit=A.&aufull=Marsh+A.&coden=ESJOE&isbn=&pages=507-512&date=2003&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 917
TITLE
  Ultrasound imaging in the preoperative estimation of the size of 
tracheostomy tube required in specialised operations in children
AUTHOR NAMES
  Hardee P.S.G.F.; Ng S.Y.; Cashman M.
AUTHOR ADDRESSES
  (Hardee P.S.G.F.; Cashman M.) Dept. of Oral/Maxillofacial Surgery, Barts and 
The London NHS Trust, Whitechapel, London E1 1BB, United Kingdom.
(Ng S.Y.) Department of Dental Radiology, GKT Dental Institute, Caldecot 
Road, London SE5 9RW, United Kingdom.
CORRESPONDENCE ADDRESS
  P.S.G.F. Hardee, Dept. of Oral/Maxillofacial Surgery, Barts and The London 
NHS Trust, Whitechapel, London E1 1BB, United Kingdom.
FULL RECORD ENTRY DATE
  2003-12-03
SOURCE
  British Journal of Oral and Maxillofacial Surgery (2003) 41:5 (312-316). 
Date of Publication: October 2003
VOLUME
  41
ISSUE
  5
FIRST PAGE
  312
LAST PAGE
  316
DATE OF PUBLICATION
  October 2003
ISSN
  0266-4356
BOOK PUBLISHER
  Churchill Livingstone, 1-3 Baxter's Place, Leith Walk, Edinburgh, United 
Kingdom.
ABSTRACT
  Background: Some children are dependent on a tracheostomy for many years. As 
they grow, larger tracheostomy tubes may be required. Although tables of 
sizes of tracheas exist for different age groups, they are estimations of 
normal and may not be accurate for atypical cases. Chest radiographs and 
computed tomograms (CT) have been used experimentally to estimate tracheal 
sizes, but are not in regular use. Method: High-resolution diagnostic 
ultrasound imaging was used to estimate the internal and external transverse 
tracheal diameter, and the depth of the trachea from the skin surface. This 
allowed selection of the correct standard pattern tracheostomy tube, or the 
construction of a custom-made tube preoperatively. Results: Four children 
with various abnormalities who were being considered for replacement 
tracheostomies were scanned. In one, diagnostic ultrasound confirmed that a 
new larger fenestrated tube could be placed, which subsequently improved 
vocalisation and respiration. In the other three, the scan showed there was 
no space to allow a larger tube to be placed. The standard tables were not 
suitable for any of these patients. Conclusion: High-resolution ultrasound 
has a role in the non-invasive measurement of the size of the tube needed 
for specialised operations in children. © 2003 The British Association of 
Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights 
reserved.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  echography; endotracheal tube; pediatric surgery; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; atlantoaxial dislocation (surgery); breathing; case report; diagnostic imaging; Down syndrome; human; male; non invasive measurement; paraplegia; preoperative evaluation; preschool child; pterygium (surgery); school child; skin surface; spinal cord transsection (surgery); standard; surgical technique; trachea; traffic accident; vocalization; 
DEVICE MANUFACTURERS
   (United Kingdom)Kapitex Healthcare
   (United Kingdom)Sims Portex
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Otorhinolaryngology (11)
  Radiology (14)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003471694
MEDLINE PMID
  14581023 (http://www.ncbi.nlm.nih.gov/pubmed/14581023)
PUI
  L37428238
DOI
  10.1016/S0266-4356(03)00125-6
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0266-4356(03)00125-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02664356&id=doi:10.1016%2FS0266-4356%2803%2900125-6&atitle=Ultrasound+imaging+in+the+preoperative+estimation+of+the+size+of+tracheostomy+tube+required+in+specialised+operations+in+children&stitle=Br.+J.+Oral+Maxillofac.+Surg.&title=British+Journal+of+Oral+and+Maxillofacial+Surgery&volume=41&issue=5&spage=312&epage=316&aulast=Hardee&aufirst=Peter+S.G.F.&auinit=P.S.G.F.&aufull=Hardee+P.S.G.F.&coden=BJOSE&isbn=&pages=312-316&date=2003&auinit1=P&auinitm=S.G.F.
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 918
TITLE
  Basilar artery thrombosis in a trauma patient. Case report and review of the 
literature
AUTHOR NAMES
  De Decker K.; Van Havenbergh T.; D'Archambeau O.; Jorens P.G.
AUTHOR ADDRESSES
  (De Decker K., koen.de.decker@uza.be; Jorens P.G.) Dept. of Intensive Care 
Medicine, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, 
Belgium.
(Van Havenbergh T.) Department of Neurosurgery, Antwerp University Hospital, 
Edegem, Belgium.
(D'Archambeau O.) Department of Radiology, Antwerp University Hospital, 
Edegem, Belgium.
CORRESPONDENCE ADDRESS
  K. De Decker, Dept. of Intensive Care Medicine, Antwerp University Hospital, 
Wilrijkstraat 10, 2650 Edegem, Belgium. Email: koen.de.decker@uza.be
FULL RECORD ENTRY DATE
  2003-11-10
SOURCE
  Resuscitation (2003) 59:1 (147-154). Date of Publication: October 2003
VOLUME
  59
ISSUE
  1
FIRST PAGE
  147
LAST PAGE
  154
DATE OF PUBLICATION
  October 2003
ISSN
  0300-9572
BOOK PUBLISHER
  Elsevier Ireland Ltd, P.O. Box 85, Limerick, Ireland.
ABSTRACT
  Thrombotic disease of the vertebrobasilar circulation is associated with a 
poor prognosis. It may occur in trauma patients, especially those with neck 
injuries and even several months after the initial insult. We report on the 
case of a young polytrauma patient, victim of a traffic accident, with 
associated cervical and thoracic spinal injuries resulting in paraplegia. 
Consciousness was not impaired initially, but during transfer to our 
hospital he became suddenly unconscious. An occluded basilar artery was 
found on angiography, but unfortunately we were unable to reopen the vessel 
with thrombolytic therapy. This case again proves that lesions of the 
vertebro-basilar system must always be suspected in neck injuries. Even 
after minor whiplash injuries, fatal basilar thrombosis may occur. A review 
of all reported cases of traumatic basilar artery thrombosis is given and 
the use of thrombolytic therapy is discussed. © 2003 Elsevier Ireland Ltd. 
All rights reserved.
EMTREE DRUG INDEX TERMS
  acetylsalicylic acid (drug therapy); alteplase (drug therapy); anticonvulsive agent (drug therapy); corticosteroid (drug therapy); dexamethasone (drug therapy); dopamine (drug dose, drug therapy); heparin (drug therapy); mannitol (drug therapy); steroid (drug therapy); streptokinase (drug therapy); urokinase (drug therapy); warfarin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artery thrombosis (diagnosis, drug therapy, surgery, therapy); basilar artery; 
EMTREE MEDICAL INDEX TERMS
  adult; anamnesis; angiography; anticoagulation; article; brain stem infarction (diagnosis); brain surgery; case report; cause of death; cerebellum infarction (diagnosis); cervical spine dislocation (surgery); cervical spine fracture (diagnosis); cervical spine injury (surgery); consciousness; conservative treatment; fatality; fibrinolytic therapy; head injury (therapy); human; intervertebral disk hernia (therapy); lung contusion (diagnosis); lung embolism (complication); male; paraplegia (complication); pleura effusion (diagnosis); priority journal; shock (drug therapy); spinal shock (drug therapy); spine fusion; thoracic spine; thorax injury (therapy); tracheotomy; traffic accident; unconsciousness; vertebral artery; whiplash injury (therapy); 
DRUG TRADE NAMES
  actilyse  Boehringer Ingelheim

  actosolv  Aventis

DRUG MANUFACTURERS
  Aventis
  Boehringer Ingelheim
CAS REGISTRY NUMBERS
  acetylsalicylic acid (493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1)
  alteplase (105857-23-6)
  dexamethasone (50-02-2)
  dopamine (51-61-6, 62-31-7)
  heparin (37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5)
  mannitol (69-65-8, 87-78-5)
  streptokinase (9002-01-1)
  urokinase (139639-24-0)
  warfarin (129-06-6, 2610-86-8, 3324-63-8, 5543-58-8, 81-81-2)
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Drug Literature Index (37)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003427500
MEDLINE PMID
  14580746 (http://www.ncbi.nlm.nih.gov/pubmed/14580746)
PUI
  L37297990
DOI
  10.1016/S0300-9572(03)00157-6
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0300-9572(03)00157-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03009572&id=doi:10.1016%2FS0300-9572%2803%2900157-6&atitle=Basilar+artery+thrombosis+in+a+trauma+patient.+Case+report+and+review+of+the+literature&stitle=Resuscitation&title=Resuscitation&volume=59&issue=1&spage=147&epage=154&aulast=De+Decker&aufirst=Koen&auinit=K.&aufull=De+Decker+K.&coden=RSUSB&isbn=&pages=147-154&date=2003&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 919
TITLE
  Inpatient chronic assisted ventilatory care: A 15-year experience
AUTHOR NAMES
  Wijkstra P.J.; Avendaño M.A.; Goldstein R.S.
AUTHOR ADDRESSES
  (Wijkstra P.J.; Avendaño M.A.; Goldstein R.S., rgoldstein@westpark.org) West 
Park Healthcare Centre, Division of Respiratory Medicine, University of 
Toronto, Toronto, Ont., Canada.
(Goldstein R.S., rgoldstein@westpark.org) West Park HealthCare Centre, 82 
Buttonwood Ave, Toronto, Ont. M6M 25J, Canada.
CORRESPONDENCE ADDRESS
  R.S. Goldstein, West Park HealthCare Centre, 82 Buttonwood Ave, Toronto, 
Ont. M6M 25J, Canada. Email: rgoldstein@westpark.org
FULL RECORD ENTRY DATE
  2003-10-14
SOURCE
  Chest (2003) 124:3 (850-856). Date of Publication: 1 Sep 2003
VOLUME
  124
ISSUE
  3
FIRST PAGE
  850
LAST PAGE
  856
DATE OF PUBLICATION
  1 Sep 2003
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Study objectives: Ventilator users who are unable to leave the acute care 
setting may be transferred to a unit for chronic assisted ventilatory care 
(CAVC) with the goal of optimizing their level of function. In this report, 
we summarize the outcomes of all patients admitted to a CAVC unit between 
1986 and 2001. Patients and methods: Fifty patients (24 with neuromuscular 
disease [NMD], 10 with spinal cord injury, [SCI], 7 with thoracic 
restriction [TR], 7 with COPD, and 2 with parenchymal restriction [PR]) were 
reviewed. Thirty-eight patients were transferred to the CAVC unit from 
intensive care, 5 patients were transferred from inpatient respiratory 
rehabilitation, 4 patients came from home, and 3 patients came from 
pediatric long-term care. At the time of CAVC unit admission, all patients 
were receiving mechanical ventilation via a tracheostomy tube. Results: 
Ventilator time increased gradually in patients with COPD from 16 h (SD, 
5.6) to 22.9 h (SD, 3.0) per day (p < 0.05), and in patients with TR from 
18.9 h (SD, 6.1) to 22.9 h (SD, 4.5) [not significant]. Five of the 10 
patients with SCI were decannulated. Functional mobility, which decreased in 
patients with COPD and patients with TR, remained stable in NMD and PR and 
improved in SCI. Eighteen patients returned home or to an attendant care 
facility (COPD, n = 1; NMD, n = 10; SCI, n = 5; PR, n = 2); 11 patients died 
in the CAVC unit (COPD, n = 6; TR, n = 3; NMD, n = 1; SCI, n = 1); and 7 
patients were transferred to intensive care, where they died. The average 
direct cost per patient per diem increased from $252 (Canadian) in 1988 to 
$335 in 2001. Conclusion: A CAVC unit can provide a safe environment for 
severely impaired, ventilator-dependent individuals, many of whom (36%) left 
for a more independent community-based environment. Better outcomes were 
seen among patients with SCI and NMD than in patients with COPD and TR.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; assisted ventilation; chronic obstructive lung disease (disease management, therapy); neuromuscular disease (disease management, therapy); spinal cord injury (disease management, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; biosafety; Canada; cannulation; cause of death; clinical feature; community care; controlled study; devices; disease severity; environmental factor; female; health care cost; health care facility; home care; hospital admission; hospital department; hospital patient; human; intensive care; intensive care unit; long term care; major clinical study; male; medical practice; mobilization; parenchyma; priority journal; statistical significance; time; tracheostomy; treatment outcome; tube; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003375782
MEDLINE PMID
  12970008 (http://www.ncbi.nlm.nih.gov/pubmed/12970008)
PUI
  L37123300
DOI
  10.1378/chest.124.3.850
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.124.3.850
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.124.3.850&atitle=Inpatient+chronic+assisted+ventilatory+care%3A+A+15-year+experience&stitle=Chest&title=Chest&volume=124&issue=3&spage=850&epage=856&aulast=Wijkstra&aufirst=Peter+J.&auinit=P.J.&aufull=Wijkstra+P.J.&coden=CHETB&isbn=&pages=850-856&date=2003&auinit1=P&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 920
TITLE
  Noninvasive interface for transtracheal mechanical ventilation for patients 
with severe cervical spine deformity
AUTHOR NAMES
  Gonzalez E.L.; Bishop R.G.; Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Dept. of Phys. Med./Rehabilitation, University Hospital B-403, 
UMDNJ-New Jersey Medical School, 150 Bergen Street, Newark, NJ 07103, United 
States.
(Gonzalez E.L.; Bishop R.G.)
CORRESPONDENCE ADDRESS
  J.R. Bach, Dept. of Phys. Med./Rehabilitation, University Hospital B-403, 
UMDNJ-New Jersey Medical School, 150 Bergen Street, Newark, NJ 07103, United 
States.
FULL RECORD ENTRY DATE
  2003-09-04
SOURCE
  American Journal of Physical Medicine and Rehabilitation (2003) 82:9 
(721-724). Date of Publication: 1 Sep 2003
VOLUME
  82
ISSUE
  9
FIRST PAGE
  721
LAST PAGE
  724
DATE OF PUBLICATION
  1 Sep 2003
ISSN
  0894-9115
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  This article describes a custom-molded patient-to-ventilator interface that 
permits mechanical ventilation via a tracheostomy site for patients for whom 
tracheostomy tubes can not be used because of severe cervical deformity. The 
nocturnal delivery of intermittent positive-pressure ventilation resulted in 
normalization of oxyhemoglobin saturation and end-tidal CO(2) and 
alleviation of symptoms of alveolar hypoventilation. Thermoplastic 
patient-ventilator tubing interfaces can be constructed to permit 
ventilatory assistance for patients with tracheostomies who can not use 
tracheostomy tubes.
EMTREE DRUG INDEX TERMS
  oxyhemoglobin (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; spine malformation (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; capnometry; case report; cerebral palsy (diagnosis); devices; female; human; hypoventilation; man machine interaction; oxygen saturation; tracheostomy; 
DEVICE MANUFACTURERS
   (United States)Pulmonetics Systems
   (United States)Shiley
CAS REGISTRY NUMBERS
  oxyhemoglobin (9061-63-6)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003342784
MEDLINE PMID
  12960915 (http://www.ncbi.nlm.nih.gov/pubmed/12960915)
PUI
  L37022522
DOI
  10.1097/01.PHM.0000073831.97443.69
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.PHM.0000073831.97443.69
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08949115&id=doi:10.1097%2F01.PHM.0000073831.97443.69&atitle=Noninvasive+interface+for+transtracheal+mechanical+ventilation+for+patients+with+severe+cervical+spine+deformity&stitle=Am.+J.+Phys.+Med.+Rehabil.&title=American+Journal+of+Physical+Medicine+and+Rehabilitation&volume=82&issue=9&spage=721&epage=724&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=AJPRE&isbn=&pages=721-724&date=2003&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 921
TITLE
  Emergency surgery in thoracoabdominal aneurysms repair: Clinical outcome
ORIGINAL (NON-ENGLISH) TITLE
  La chirurgia in emergenza degli aneurismi toraco-addominali: Risultati 
clinici
AUTHOR NAMES
  Loddo P.; Degiudici A.; Maxia A.; Pibiri L.; Pisu F.; Ruiu G.; Zanetti P.P.
AUTHOR ADDRESSES
  (Loddo P.; Degiudici A.; Maxia A.; Pibiri L.; Pisu F.; Ruiu G.; Zanetti 
P.P.) Div. of Thorac. and Vascular Surgery, Heart Department, G. Brotzu 
Hospital, Cagliari, Italy.
(Zanetti P.P.) Dipartimento Cuore, Div. Chirurgia Toraco-Vascolare, Ospedale 
G. Brotzu, Via Peretti 2, 09134 Cagliari, Italy.
CORRESPONDENCE ADDRESS
  P.P. Zanetti, Dipartimento Cuore, Div. Chirurgia Toraco-Vascolare, Ospedale 
G. Brotzu, Via Peretti 2, 09134 Cagliari, Italy.
FULL RECORD ENTRY DATE
  2003-11-19
SOURCE
  Giornale Italiano di Chirurgia Vascolare (2003) 10:3 (255-267). Date of 
Publication: Sep 2003
VOLUME
  10
ISSUE
  3
FIRST PAGE
  255
LAST PAGE
  267
DATE OF PUBLICATION
  Sep 2003
ISSN
  1122-8679
ABSTRACT
  Aim. Surgical treatment of thoracoabdominal aneurysms (TAA) represents a 
burdensome problem for the vascular surgeon and may become a formable 
challenge in an emergency procedure. In patients with hemodynamic 
instability and prolonged low blood pressure, protective measures (cerebral 
spinal fluid drain-age and/or Bio-pump) against spinal cord, visceral or 
renal ischemia may be ineffective or impracticable. Methods. We report our 
experience with 28 emergency-operated patients with TAA out of 117 treated 
between 1994 and 2001; 23 were men and 5 were women (age range, 33-83 years; 
mean, 62 years); 57.1% presented with true aneurysms, 42.9% with dissecting 
aneurysms; 89.2% were hemodynamically unstable; 10.7% were hemodynamically 
stable. Based on findings from computed tomography scanning with contrast 
media, the TAA were evaluated by the Crawford classification as 9 type I, 9 
type II, 8 type III, and 2 type IV. The surgical technique adopted in the 
emergency treatment of TAA is described. Results. Overall mortality was 
42.8% (12/28); 4 deaths occurred during the operation, 7 within 30 days and 
1 within 60 days. Early deaths subdivided by Crawford TAA type were: 2/9 
type I, 4/9 type II, 4/8 type III and 1/2 type IV. Out of 24 patients, 4 
developed paraplegia/paraparesis (16.6%); spinal cord damage was permanent 
in 3 out of 4 and bilateral in 3 out of 4 patients. Type H TAA, which was 
present in 4 patients, of which 2 developed paraplegia/paresis (P/P), was 
found to be a high risk factor (p=0.02), as was prolonged intra- and 
postoperative low blood pressure (4 out of 4 patients), (p=0.01). Acute 
renal failure (ARF) was present in 16.6% of cases (4/24). Dialysis was found 
to be a risk factor for hospital mortality (p=0.03). Pulmonary insufficiency 
was present in 33.3% (8/24); 3 patients received tracheostomy, of which 2 
died (p=0.04). Postoperative bleeding was present in 20.8% (5/24). Inferior 
laryngeal nerve palsy was present in 16.6% (4/24). The follow-up period 
comprised 12-60 months; the 6-year actuarial survival rate of the 16 
patients discharged from the hospital was 50%. Conclusion. The literature 
contains few studies on emergency treatment for TAA; the study data do not 
distinguish between hemodynamically stable and unstable patients. It is well 
known that the 2 different classes of patients are not comparable because 
hemodynamically patients do not differ from those who receive elective 
surgery. Wider studies are needed to shed light on the pathophysiology and 
surgical management of TAA, which are still being treated according to the 
individual surgeon's experience.
EMTREE DRUG INDEX TERMS
  contrast medium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal aortic aneurysm (disease management, surgery); aneurysm surgery; emergency surgery; thoracic aorta aneurysm (disease management, surgery); 
EMTREE MEDICAL INDEX TERMS
  acute kidney failure (complication); adult; aged; article; clinical article; clinical practice; computer assisted tomography; contrast enhancement; disease classification; dissecting aortic aneurysm (disease management, surgery); experience; female; follow up; hemodialysis; hemodynamic monitoring; high risk patient; human; hypotension; laryngeal nerve; lung insufficiency (complication); male; nerve paralysis (complication); outcomes research; paraplegia (complication); postoperative hemorrhage (complication); risk assessment; risk factor; scoring system; spinal cord lesion (complication); surgeon; surgical mortality; surgical technique; survival rate; tracheostomy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Health Policy, Economics and Management (36)
  Internal Medicine (6)
  Surgery (9)
LANGUAGE OF ARTICLE
  Italian, English
LANGUAGE OF SUMMARY
  English, Italian
EMBASE ACCESSION NUMBER
  2003443058
PUI
  L37345659
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11228679&id=doi:&atitle=Emergency+surgery+in+thoracoabdominal+aneurysms+repair%3A+Clinical+outcome&stitle=G.+Ital.+Chir.+Vasc.&title=Giornale+Italiano+di+Chirurgia+Vascolare&volume=10&issue=3&spage=255&epage=267&aulast=Loddo&aufirst=P.&auinit=P.&aufull=Loddo+P.&coden=GICVF&isbn=&pages=255-267&date=2003&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 922
TITLE
  Long term ventilation in neurogenic respiratory failure
AUTHOR NAMES
  Howard R.S.; Davidson C.
AUTHOR ADDRESSES
  (Howard R.S., robin.howard@uclh.org) Batten Harris Med. Intensive Care U., 
Natl. Hosp. for Neurol./Neurosurgery, Queen Square, London WC1N 3BG, United 
Kingdom.
(Howard R.S., robin.howard@uclh.org; Davidson C.) Lane-Fox Respiratory Unit, 
Department of Neurology, Guy's and St. Thomas' Hospital, London, United 
Kingdom.
CORRESPONDENCE ADDRESS
  R.S. Howard, Batten Harris Med. Intensive Care U., Natl. Hosp. for 
Neurol./Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom. Email: 
robin.howard@uclh.org
FULL RECORD ENTRY DATE
  2003-10-07
SOURCE
  Neurology in Practice (2003) 74:3 (iii24-iii30). Date of Publication: 
September 2003
VOLUME
  74
ISSUE
  3
DATE OF PUBLICATION
  September 2003
ISSN
  1473-7086
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; respiratory failure (etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  anterior horn cell disease; breathing disorder; breathing muscle; breathing pattern; central nervous system disease; cervical spinal cord injury; clinical feature; coughing; human; intermittent positive pressure ventilation; long term care; lung alveolus hypoventilation; muscle weakness; neuromuscular junction disorder; neuropathy; palliative therapy; pathophysiology; positive end expiratory pressure; priority journal; respiration control; review; risk factor; sleep disordered breathing; tracheostomy; treatment indication; treatment outcome; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2003390163
MEDLINE PMID
  12933911 (http://www.ncbi.nlm.nih.gov/pubmed/12933911)
PUI
  L37174678
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14737086&id=doi:&atitle=Long+term+ventilation+in+neurogenic+respiratory+failure&stitle=Neurol.+Practice&title=Neurology+in+Practice&volume=74&issue=3&spage=&epage=&aulast=Howard&aufirst=Robin+S.&auinit=R.S.&aufull=Howard+R.S.&coden=NPERA&isbn=&pages=-&date=2003&auinit1=R&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 923
TITLE
  Difficult airway in a child with spinal muscular atrophy type I
AUTHOR NAMES
  Arima H.; Sobue K.; Tanaka S.; Morishima T.; Ando H.; Katsuya H.
AUTHOR ADDRESSES
  (Arima H., arima@sb.starcat.ne.jp; Sobue K.; Tanaka S.; Morishima T.; Ando 
H.) Department of Anaesthesia, Okazaki City Hospital, Okazaki, Japan.
(Katsuya H.) Dept. Anaesthiol./Med. Crisis Mgmt., Nagoya City Univ. Grad. 
Sch. Med. S., Nagoya, Japan.
(Arima H., arima@sb.starcat.ne.jp) Department of Anaesthesia, Okazaki City 
Hospital, 3-1 Goshoai, Koryuji-Cho, Okazaki 444-8553, Japan.
CORRESPONDENCE ADDRESS
  H. Arima, Department of Anaesthesia, Okazaki City Hospital, 3-1 Goshoai, 
Koryuji-Cho, Okazaki 444-8553, Japan. Email: arima@sb.starcat.ne.jp
FULL RECORD ENTRY DATE
  2003-06-09
SOURCE
  Paediatric Anaesthesia (2003) 13:4 (342-344). Date of Publication: 2003
VOLUME
  13
ISSUE
  4
FIRST PAGE
  342
LAST PAGE
  344
DATE OF PUBLICATION
  2003
ISSN
  1155-5645
BOOK PUBLISHER
  Blackwell Publishing Ltd, 9600 Garsington Road, Oxford, United Kingdom.
ABSTRACT
  Spinal muscular atrophy (SMA) type I is a relatively common inherited 
neuromuscular disease of hypotonic newborns, but is not associated with 
craniofacial abnormalities. There is nothing in the literature about 
difficult intubation in patients affected by this disease. We report a case 
of 34-month-old girl with SMA type I who was scheduled for emergency 
endoscopic laser treatment of tracheal stenosis caused by granulations. 
Tracheostomy was performed at 17 months of age and before this, the 
orotracheal tube was changed periodically without difficulty. For this laser 
treatment, orotracheal intubation was required. Preoperative physical 
examination revealed micrognathia and class II malocclusion. Opening her 
mouth was not difficult. Although difficult orotracheal intubation was 
predictable, we attempted to intubate her trachea as usual, but could not 
visualize the epiglottis. We decided to proceed with retrograde intubation, 
one of the standard techniques employed in a child with a difficult airway, 
via the tracheostome. A feeding nasogastric catheter was used as a guide 
catheter, and our strategy was successful. In this study we report a case of 
difficult airway in a child with SMA type I. The relationship between SMA 
type I with a tracheostome and difficult airway are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  article; case report; craniofacial malformation; epiglottis; female; granulation tissue; human; infantile hypotonia; laser surgery; micrognathia; nasogastric tube; neuromuscular disease; preschool child; priority journal; trachea stenosis (surgery); tracheotomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003218826
MEDLINE PMID
  12753449 (http://www.ncbi.nlm.nih.gov/pubmed/12753449)
PUI
  L36629651
DOI
  10.1046/j.1460-9592.2003.01042.x
FULL TEXT LINK
  http://dx.doi.org/10.1046/j.1460-9592.2003.01042.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11555645&id=doi:10.1046%2Fj.1460-9592.2003.01042.x&atitle=Difficult+airway+in+a+child+with+spinal+muscular+atrophy+type+I&stitle=Paediatr.+Anaesth.&title=Paediatric+Anaesthesia&volume=13&issue=4&spage=342&epage=344&aulast=Arima&aufirst=Hajime&auinit=H.&aufull=Arima+H.&coden=PAANF&isbn=&pages=342-344&date=2003&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 924
TITLE
  Dysphagia in patients with acute cervical spinal cord injury
AUTHOR NAMES
  Wolf C.; Meiners T.H.
AUTHOR ADDRESSES
  (Wolf C.; Meiners T.H.) Spinal Cord Injury Center, Werner Wicker Klinik, Bad 
Wildungen, Germany.
(Wolf C.) Spinal Cord Injury Center, Werner Wicker Klinik, Im Kreuzfeld 4, 
D-34537. Bad Wildungen, Germany.
CORRESPONDENCE ADDRESS
  C. Wolf, Spinal Cord Injury Center, Werner Wicker Klinik, Im Kreuzfeld 4, 
D-34537. Bad Wildungen, Germany.
FULL RECORD ENTRY DATE
  2003-06-25
SOURCE
  Spinal Cord (2003) 41:6 (347-353). Date of Publication: 1 Jun 2003
VOLUME
  41
ISSUE
  6
FIRST PAGE
  347
LAST PAGE
  353
DATE OF PUBLICATION
  1 Jun 2003
ISSN
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: Longitudinal observational. Objectives: (a) To establish a 
reliable and feasible method to indicate the presence and severity of 
dysphagia and (b) to establish a course of treatment in individuals 
presenting with cervical spinal cord injury (CSCI). Setting: Spinal Cord 
Injury Center, Werner Wicker Klinik, Bad Wildungen, Germany. Patients and 
methods: This is a cross-sectional study of 51 patients consecutively 
admitted to the Intensive Care Unit of the SCI in-patient service. They were 
subjected to neurological and fiberoptic endoscopic examination of 
swallowing (FEES). Data concerning artificial respiration, presence of 
tracheostomy, oral or non-oral feeding were obtained from the medical 
charts. Statistics were carried out by a calculation of a nonparametric 
correlation (Spearman). Results: Five levels of dysphagia could be 
distinguished. At levels 1 and 2, patients presented with a severe 
impairment of swallowing, in level 3 aspiration was met by a powerful 
coughing reflex, level 4 comprised a laryngeal edema and/or a mild 
aspiration of fluids only and at level 5 laryngeal function was not 
compromised. On admission, 20 patients with CSCI presented with mild (level 
4), eight with moderate (level 3) and 13 with severe dysphagia (levels 1 and 
2). In 10 no signs of dysphagia could be detected. After treatment, level 1 
was no longer detected, one patient showed level 2, two patients showed 
level 3, all other patients showed only mild or no signs of dysphagia any 
longer. Conclusions: Dysphagia of various severities was present in the 
majority of these patients with CSCI together with respiratory 
insufficiency. FEES allows for the detection and classification of dysphagia 
as well as for an evaluation of the therapeutic management. Under 
interdisciplinary treatment the prognosis of dysphagia is good.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; dysphagia (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; aspiration; controlled study; coughing; disease severity; fiberscope endoscopy; fluoroscopy; Germany; human; intensive care unit; larynx edema (complication); longitudinal study; major clinical study; neurologic examination; priority journal; prognosis; reliability; respiratory failure (complication, therapy); tracheostomy; 
DEVICE MANUFACTURERS
   (Germany)Olympus
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003239071
MEDLINE PMID
  12746741 (http://www.ncbi.nlm.nih.gov/pubmed/12746741)
PUI
  L36713045
DOI
  10.1038/sj.sc.3101440
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3101440
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3101440&atitle=Dysphagia+in+patients+with+acute+cervical+spinal+cord+injury&stitle=Spinal+Cord&title=Spinal+Cord&volume=41&issue=6&spage=347&epage=353&aulast=Wolf&aufirst=C.&auinit=C.&aufull=Wolf+C.&coden=SPCOF&isbn=&pages=347-353&date=2003&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 925
TITLE
  Psychological management of two cases of self injury on the paediatric 
intensive care unit
AUTHOR NAMES
  Colville G.A.; Mok Q.
AUTHOR ADDRESSES
  (Colville G.A., g.colville@sghms.ac.uk) Department of Psychology, St. 
George's Hospital Medical School, London, United Kingdom.
(Mok Q.) Paediatric Intensive Care Unit, Gt. Ormond St. Hospital for 
Children, London, United Kingdom.
(Colville G.A., g.colville@sghms.ac.uk) Department of Psychology, St. 
George's Hospital Medical School, London SW17 0RE, United Kingdom.
CORRESPONDENCE ADDRESS
  G.A. Colville, Department of Psychology, St. George's Hospital Medical 
School, London SW17 0RE, United Kingdom. Email: g.colville@sghms.ac.uk
FULL RECORD ENTRY DATE
  2003-04-14
SOURCE
  Archives of Disease in Childhood (2003) 88:4 (335-336). Date of Publication: 
1 Apr 2003
VOLUME
  88
ISSUE
  4
FIRST PAGE
  335
LAST PAGE
  336
DATE OF PUBLICATION
  1 Apr 2003
ISSN
  0003-9888
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  Self injury has not been previously reported in an intensive care setting. 
Two cases are presented of ventilator dependent children with high spinal 
cord lesions who exhibited an unusual form of self mutilation, namely lip 
biting. The key to extinguishing this behaviour was to address the 
children's psychological needs.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  automutilation (etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  anger; article; assisted ventilation; behavior therapy; bite; case report; child; clinical feature; fear; female; human; intensive care; play therapy; priority journal; psychosocial withdrawal; social isolation; spinal cord lesion; spine fusion; stress; symptom; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Psychiatry (32)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003145521
MEDLINE PMID
  12651763 (http://www.ncbi.nlm.nih.gov/pubmed/12651763)
PUI
  L36398975
DOI
  10.1136/adc.88.4.335
FULL TEXT LINK
  http://dx.doi.org/10.1136/adc.88.4.335
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039888&id=doi:10.1136%2Fadc.88.4.335&atitle=Psychological+management+of+two+cases+of+self+injury+on+the+paediatric+intensive+care+unit&stitle=Arch.+Dis.+Child.&title=Archives+of+Disease+in+Childhood&volume=88&issue=4&spage=335&epage=336&aulast=Colville&aufirst=G.A.&auinit=G.A.&aufull=Colville+G.A.&coden=ADCHA&isbn=&pages=335-336&date=2003&auinit1=G&auinitm=A
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 926
TITLE
  Stab wounds to the neck with partial transsection of the spinal cord and 
penetrating injury to the esophagus
AUTHOR NAMES
  Platz A.; Kossmann T.; Payne B.; Trentz O.
AUTHOR ADDRESSES
  (Platz A., andreas.platz@chi.usz.ch; Kossmann T.; Payne B.; Trentz O.) 
Department of Surgery, Division of Trauma Surgery, University Hospital 
Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.
CORRESPONDENCE ADDRESS
  A. Platz, Department of Surgery, Division of Trauma Surgery, University 
Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland. Email: 
andreas.platz@chi.usz.ch
FULL RECORD ENTRY DATE
  2003-04-12
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2003) 54:3 
(612-614). Date of Publication: 1 Mar 2003
VOLUME
  54
ISSUE
  3
FIRST PAGE
  612
LAST PAGE
  614
DATE OF PUBLICATION
  1 Mar 2003
ISSN
  1079-6061
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
EMTREE DRUG INDEX TERMS
  methylene blue; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus injury (etiology, surgery); neck injury (etiology, surgery); spinal cord transsection (etiology, surgery); stab wound; 
EMTREE MEDICAL INDEX TERMS
  abdominal injury (surgery); adult; article; body position; case report; clinical feature; colon perforation (surgery); female; hemorrhagic shock (complication); human; intubation; laparotomy; liquorrhea (complication, surgery); physical examination; priority journal; quadriplegia (rehabilitation); resuscitation; surgical technique; tracheostomy; treatment outcome; 
CAS REGISTRY NUMBERS
  methylene blue (61-73-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2003138575
MEDLINE PMID
  12634548 (http://www.ncbi.nlm.nih.gov/pubmed/12634548)
PUI
  L36383767
DOI
  10.1097/01.TA.0000046445.94348.0F
FULL TEXT LINK
  http://dx.doi.org/10.1097/01.TA.0000046445.94348.0F
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10796061&id=doi:10.1097%2F01.TA.0000046445.94348.0F&atitle=Stab+wounds+to+the+neck+with+partial+transsection+of+the+spinal+cord+and+penetrating+injury+to+the+esophagus&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=54&issue=3&spage=612&epage=614&aulast=Platz&aufirst=Andreas&auinit=A.&aufull=Platz+A.&coden=JOTRF&isbn=&pages=612-614&date=2003&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 927
TITLE
  Respiratory management of pediatric patients with spinal cord injuries: 
Retrospective review of the duPont experience
AUTHOR NAMES
  Padman R.; Alexander M.; Thorogood C.; Porth S.
AUTHOR ADDRESSES
  (Padman R., rpadman@nemours.org; Porth S.) Division of Pulmonology, Nemours 
Children's Clinic-Wilmington, Alfred I. duPont Hosp. for Children, 
Wilmington, DE, United States.
(Alexander M.; Thorogood C.) Division of Rehabilitation Medicine, Nemours 
Children's Clinic-Wilmington, Alfred I. duPont Hosp. for Children, 
Wilmington, DE, United States.
(Padman R., rpadman@nemours.org) c/o Editorial Services, Alfred I. duPont 
Hosp. for Children, P.O. Box 269, Wilmington, DE 19899, United States.
CORRESPONDENCE ADDRESS
  R. Padman, c/o Editorial Services, Alfred I. duPont Hosp. for Children, P.O. 
Box 269, Wilmington, DE 19899, United States. Email: rpadman@nemours.org
FULL RECORD ENTRY DATE
  2003-09-25
SOURCE
  Neurorehabilitation and Neural Repair (2003) 17:1 (32-36). Date of 
Publication: 1 Mar 2003
VOLUME
  17
ISSUE
  1
FIRST PAGE
  32
LAST PAGE
  36
DATE OF PUBLICATION
  1 Mar 2003
ISSN
  0888-4390
BOOK PUBLISHER
  SAGE Publications Inc., 2455 Teller Road, Thousand Oaks, United States.
ABSTRACT
  Pulmonary complications contribute to morbidity and mortality in spinal cord 
injuries (SCIs). A retrospective review of 20 years of experience with 
tracheostomy- and ventilator-dependent SCI children is presented. The 
authors developed and analyzed a database of 47 children (average age = 11.4 
years). Of the patients, 27% had concomitant brain injuries, 690 had prior 
histories of reactive airway disease, and 2% had thoracic fractures. 
Injuries were caused by motor vehicle accidents (53%); gunshot wounds (19%); 
sports-related accidents (19%); and vascular injuries, transverse myelitis, 
or spinal tumors (8%). Of the injuries, 52% were high level (C1 to C2) and 
48% were mid- or low level (C3 to C5). Two groups were analyzed for 
demographic information. Complications included tracheitis, atelectasis, and 
pneumonia. Mean tidal volume was 14 cm(2)/kg (maximum = 22 cm(2)/kg). 
Bedside lung function parameters were attempted to assess readiness and the 
rapidity of weans. T-piece sprints were used to successfully wean 63% of 
patients. Successfully weaned patients were compared with those not weaned. 
No deaths or readmissions for late-onset respiratory failure postwean 
occurred. The authors' clinical impression favors higher tidal volumes and 
aggressive bronchial hygiene to minimize pulmonary complications and enhance 
weaning. Successfully weaned patients had fewer complications. A critical 
pathway for respiratory management of SCI children is presented.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure (complication, therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; atelectasis (complication); blood vessel injury; child; clinical article; gunshot injury; human; myelitis; pneumonia (complication); spinal cord tumor; sport injury; tidal volume; tracheitis (complication); tracheostomy; traffic accident; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003370576
MEDLINE PMID
  12645443 (http://www.ncbi.nlm.nih.gov/pubmed/12645443)
PUI
  L37102025
DOI
  10.1177/0888439003251751
FULL TEXT LINK
  http://dx.doi.org/10.1177/0888439003251751
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08884390&id=doi:10.1177%2F0888439003251751&atitle=Respiratory+management+of+pediatric+patients+with+spinal+cord+injuries%3A+Retrospective+review+of+the+duPont+experience&stitle=Neurorehabil.+Neural+Repair&title=Neurorehabilitation+and+Neural+Repair&volume=17&issue=1&spage=32&epage=36&aulast=Padman&aufirst=Raj&auinit=R.&aufull=Padman+R.&coden=JNRHF&isbn=&pages=32-36&date=2003&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 928
TITLE
  Mechanical insufflation/exufflation: Has it come of age? A commentary
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu) Dept. of Physical Medicine/Rehab., Univ. of 
Med./Dent. of New Jersey, New Jersey Medical School, 150 Bergen Street, 
Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Dept. of Physical Medicine/Rehab., University Hospital B-403, New 
Jersey Medical School, 150 Bergen Street, Newark, NJ 07103, United States. 
Email: bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2003-03-31
SOURCE
  European Respiratory Journal (2003) 21:3 (385-386). Date of Publication: 1 
Mar 2003
VOLUME
  21
ISSUE
  3
FIRST PAGE
  385
LAST PAGE
  386
DATE OF PUBLICATION
  1 Mar 2003
ISSN
  0903-1936
BOOK PUBLISHER
  European Respiratory Society, 4 Ave Sainte-Luce, Lausanne, Switzerland.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; 
EMTREE MEDICAL INDEX TERMS
  abdominal pressure; abdominal wall musculature; acute respiratory failure (surgery, therapy); aeration; airway dynamics; amyotrophic lateral sclerosis (therapy); atelectasis; breathing muscle; bronchus secretion; bulbar paralysis; chronic obstructive lung disease (therapy); coughing; diaphragm paralysis (surgery, therapy); Duchenne muscular dystrophy (therapy); editorial; expiratory reserve volume; glottis; human; intercostal muscle; lung clearance; lung volume; medical device; muscle function; muscle weakness; neuromuscular disease (surgery, therapy); peak expiratory flow; positive end expiratory pressure; priority journal; respiratory tract infection; spinal cord injury; spinal muscular atrophy (therapy); trachea stenosis (therapy); tracheotomy; 
DEVICE TRADE NAMES
  Cough-Assist  , United StatesEmerson

DEVICE MANUFACTURERS
   (United States)Emerson
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2003120554
MEDLINE PMID
  12661989 (http://www.ncbi.nlm.nih.gov/pubmed/12661989)
PUI
  L36336193
DOI
  10.1183/09031936.03.00098702
FULL TEXT LINK
  http://dx.doi.org/10.1183/09031936.03.00098702
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09031936&id=doi:10.1183%2F09031936.03.00098702&atitle=Mechanical+insufflation%2Fexufflation%3A+Has+it+come+of+age%3F+A+commentary&stitle=Eur.+Respir.+J.&title=European+Respiratory+Journal&volume=21&issue=3&spage=385&epage=386&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=ERJOE&isbn=&pages=385-386&date=2003&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 929
TITLE
  Dysphagia due to C(4-5) spinal cord injury and its mechanism - Report of a 
case
AUTHOR NAMES
  Ito H.
AUTHOR ADDRESSES
  (Ito H.)
FULL RECORD ENTRY DATE
  2003-02-04
SOURCE
  Otolaryngology - Head and Neck Surgery (Tokyo) (2003) 75:1 (58-62). Date of 
Publication: 2003
VOLUME
  75
ISSUE
  1
FIRST PAGE
  58
LAST PAGE
  62
DATE OF PUBLICATION
  2003
ISSN
  0914-3491
ABSTRACT
  A 25-year-old man with C(4-5) spinal cord injury who underwent anterior 
cervical fusion had disphagia after the operation. Dysphagia was resulted 
from pain after the operation, but not from the cranial nerve disorders. The 
respiratory dysfunction, placement of a naso-tracheal tube, tracheostomy and 
the placement of a tracheal tube, which resulted in difficulty of 
expectoration of pooled materials in the hypopharynx and the upper trachea, 
made his dysphagia more serious. The serious dysphagia consequently required 
the placement of a tracheal tube. Cutting this vicious circle by the medical 
management and the physical therapy for respiratory dysfunction, we could 
succeed in his oral intake. Excluding the factors influencing negatively to 
dysphagia is important.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (complication); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; cervical spine; endotracheal intubation; endotracheal tube; human; male; nasotracheal intubation; postoperative pain; respiratory failure; spine fusion; tracheostomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2003045439
PUI
  L36125376
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09143491&id=doi:&atitle=Dysphagia+due+to+C4-5+spinal+cord+injury+and+its+mechanism+-+Report+of+a+case&stitle=Otolaryngol.+Head+Neck+Surg.+Tokyo&title=Otolaryngology+-+Head+and+Neck+Surgery+%28Tokyo%29&volume=75&issue=1&spage=58&epage=62&aulast=Ito&aufirst=Hiroyuki&auinit=H.&aufull=Ito+H.&coden=JITGE&isbn=&pages=58-62&date=2003&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 930
TITLE
  Bilateral vocal cord paralysis caused by cervical spinal osteophytes
AUTHOR NAMES
  Aydin K.; Ulug T.; Simsek T.
AUTHOR ADDRESSES
  (Aydin K.; Simsek T.) Department of Radiology, Istanbul University, Medical 
School, Capa, Istanbul, Turkey.
(Ulug T.) Department of ENT, Istanbul University, Medical School, Capa, 
Istanbul, Turkey.
CORRESPONDENCE ADDRESS
  K. Aydin, B.Mehmetpasa sokak Yavuz Apt., Camlikyolu, Etiler / Istanbul, 
Turkey.
FULL RECORD ENTRY DATE
  2003-02-11
SOURCE
  British Journal of Radiology (2002) 75:900 (990-993). Date of Publication: 1 
Dec 2002
VOLUME
  75
ISSUE
  900
FIRST PAGE
  990
LAST PAGE
  993
DATE OF PUBLICATION
  1 Dec 2002
ISSN
  0007-1285
BOOK PUBLISHER
  British Institute of Radiology, 36 Portland Place, London, United Kingdom.
ABSTRACT
  Thyroid and cervical surgery, tracheal intubation, trauma and 
neurodegenerative and neuromuscular diseases may cause bilateral vocal cord 
paralysis. There are only a few reported cases of bilateral cord paralysis 
associated with cervical hyperostosis in the English literature. We report 
the MR and CT findings of a case of bilateral vocal cord paralysis caused by 
cervical spinal osteophytes compressing the recurrent laryngeal nerves.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  osteophyte; vocal cord paralysis (complication, diagnosis, etiology); 
EMTREE MEDICAL INDEX TERMS
  aged; airway obstruction (complication, diagnosis, etiology, surgery); anamnesis; anemia; article; case report; cervical spine; computer assisted tomography; disease association; disease severity; electromyography; follow up; hoarseness; human; hyperostosis; laboratory test; laryngoscopy; magnet; male; muscle rigidity; nerve compression; nuclear magnetic resonance imaging; peripheral neuropathy; recurrent laryngeal nerve; stridor; surgical technique; tracheotomy; 
DEVICE TRADE NAMES
  Magnetom impact  , GermanySiemens

DEVICE MANUFACTURERS
   (Germany)Siemens
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Radiology (14)
  General Pathology and Pathological Anatomy (5)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2003055229
MEDLINE PMID
  12515709 (http://www.ncbi.nlm.nih.gov/pubmed/12515709)
PUI
  L36149765
DOI
  10.1259/bjr.75.900.750990
FULL TEXT LINK
  http://dx.doi.org/10.1259/bjr.75.900.750990
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00071285&id=doi:10.1259%2Fbjr.75.900.750990&atitle=Bilateral+vocal+cord+paralysis+caused+by+cervical+spinal+osteophytes&stitle=Br.+J.+Radiol.&title=British+Journal+of+Radiology&volume=75&issue=900&spage=990&epage=993&aulast=Aydin&aufirst=Kubilay&auinit=K.&aufull=Aydin+K.&coden=BJRAA&isbn=&pages=990-993&date=2002&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 931
TITLE
  Major respiratory tract traumas
ORIGINAL (NON-ENGLISH) TITLE
  Travmi na magistralnite vuzdukhonosni putishta.
AUTHOR NAMES
  Petrov D.; Obretenov E.; Kalaidzhiev G.; Plochev M.; Kostadinov D.
AUTHOR ADDRESSES
  (Petrov D.; Obretenov E.; Kalaidzhiev G.; Plochev M.; Kostadinov D.)
CORRESPONDENCE ADDRESS
  D. Petrov,
FULL RECORD ENTRY DATE
  2003-01-07
SOURCE
  Khirurgiia (2002) 58:1 (28-31). Date of Publication: 2002
VOLUME
  58
ISSUE
  1
FIRST PAGE
  28
LAST PAGE
  31
DATE OF PUBLICATION
  2002
ISSN
  0450-2167
ABSTRACT
  Between 1988 and 2000 a total of 33 patients with traumatic tracheobronchial 
lesions were diagnosed and treated. The trauma was penetrating in 7 (stab 
and gun-shot), blunt in 10 (car accidents, compression and falling from 
heights) and iatrogenic in 16 of them (postintubational--15, after foreign 
body extraction--1). The main clinical and radiological features were 
subcutaneous emphysema, hemoptysis, respiratory insufficiency, 
pneumomediastinum and pneumothorax. The diagnosis was confirmed in all 
patients by early fiberoptic bronchoscopy. "Watch and see" tactics with 
massive antibiotics therapy was followed in 4 (12%) patients. A surgical 
treatment was carried out in 29 (88%) patients as follows: simple repair--19 
(58%), left pneumonectomy--2 (6%), tracheal resection and anastomosis "end 
to end"--2 (6%), tracheostomy--1 (3%), thoracocenthesis and drainage--3 (9%) 
and cervical mediastinotomy--2 (6%). The operative mortality was 9%. The 
cause of death in these 3 patients were associated brain and spinal cord 
injuries. In the rest of patients the early and long-term postoperative 
results were considered very good.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  blunt trauma (diagnosis, surgery); bronchus (surgery); penetrating trauma (diagnosis, surgery); thorax injury (diagnosis, surgery); thorax surgery; trachea (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; bronchoscopy; child; human; injury; male; middle aged; preschool child; 
LANGUAGE OF ARTICLE
  Bulgarian
MEDLINE PMID
  12515032 (http://www.ncbi.nlm.nih.gov/pubmed/12515032)
PUI
  L36475849
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=04502167&id=doi:&atitle=Major+respiratory+tract+traumas&stitle=Khirurgiia+%28Sofiia%29&title=Khirurgiia&volume=58&issue=1&spage=28&epage=31&aulast=Petrov&aufirst=D.&auinit=D.&aufull=Petrov+D.&coden=&isbn=&pages=28-31&date=2002&auinit1=D&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 932
TITLE
  Hypothermic cardiopulmonary bypass and circulatory arrest for operations on 
the descending thoracic and thoracoabdominal aorta
AUTHOR NAMES
  Kouchoukos N.T.; Masetti P.; Rokkas C.K.; Murphy S.F.
AUTHOR ADDRESSES
  (Kouchoukos N.T., ntkouch@aol.com; Masetti P.; Rokkas C.K.; Murphy S.F.) 
Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical 
Center, St. Louis, MO, United States.
(Kouchoukos N.T., ntkouch@aol.com) Cardiac, Thoracic and Vascular Surgery, 
Inc., 3009 North Ballas Rd, St. Louis, MO 63348, United States.
CORRESPONDENCE ADDRESS
  N.T. Kouchoukos, Cardiac, Thorac./Vasc. Surgery, Inc., 3009 North Ballas Rd, 
St. Louis, MO 63348, United States. Email: ntkouch@aol.com
FULL RECORD ENTRY DATE
  2002-11-12
SOURCE
  Annals of Thoracic Surgery (2002) 74:5 (S1885-S1887). Date of Publication: 1 
Nov 2002
VOLUME
  74
ISSUE
  5
DATE OF PUBLICATION
  1 Nov 2002
ISSN
  0003-4975
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Background. Hypothermic cardiopulmonary bypass with circulatory arrest is an 
important adjunct for operations on the distal aortic arch, the descending 
thoracic, and the thoracoabdominal aorta. The safety and efficacy of this 
technique when compared with other adjuncts (ie, simple aortic clamping, 
partial cardiopulmonary bypass, regional hypothermia) is not clearly 
established. Methods. One hundred and ninety-two patients (age range, 20 to 
83 years) with descending thoracic or thoracoabdominal aortic disease had 
resection and graft replacement of the involved aortic segments using 
hypothermic cardiopulmonary bypass and intervals of circulatory arrest 
(mean, 38 minutes). The technique was used when the location and severity of 
disease precluded placement of clamps on the proximal aorta (31 patients) or 
(in 161 patients) when extensive thoracic (47) or thoracoabdominal (114) 
aortic disease was present, and the risk for development of spinal cord 
ischemic injury was judged to be increased. Lower intercostal and lumbar 
arteries were attached separately to the aortic graft in 101 of the 161 
patients (63%) who had extensive aortic replacement. No other adjuncts for 
spinal cord protection were used. Results. The 30-day mortality was 6.8% (13 
patients). It was 40% (8 of 20) for patients having emergent operations 
(acute aortic dissection or rupture) and 2.9% (5 of 172) for all others (p < 
0.001). The 90-day mortality was 12.5% (24 patients). Paraplegia occurred in 
4 and paraparesis in 1 (full recovery) of the 186 operative survivors whose 
lower limb function could be assessed postoperatively (2.7%). Among the 109 
survivors with thoracoabdominal aortic disease, early paraplegia occurred in 
1 of 36 with Crawford extent I, 0 of 42 with extent II, and 2 of 31 with 
extent III disease. One patient (extent II) developed paraplegia on the 9th 
postoperative day after a hypotensive episode. None of the 47 patients with 
aortic dissection developed paralysis. Among the 186 operative survivors, 
renal dialysis was required in 4 patients (2.2%), prolonged inotropic 
support in 18 (10%), reoperation for bleeding in 9 (5%), mechanical 
ventilation (≥ 48 hours) in 64 (34%), and tracheostomy in 17 (9%). Four 
patients (2%) sustained a stroke. Conclusions. Hypothermic cardiopulmonary 
bypass with circulatory arrest provides safe and substantial protection 
against paralysis and renal, cardiac, and visceral organ system failure that 
equals or exceeds that of other currently used techniques but without the 
need of other adjuncts. © 2002 by The Society of Thoracic Surgeons.
EMTREE DRUG INDEX TERMS
  inotropic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal aorta; aortic disease (surgery); aortic surgery; extracorporeal circulation; induced hypothermia; thoracic aorta; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; aortic clamping; aortic dissection (complication, surgery); aortic graft; aortic reconstruction; aortic rupture (complication, surgery); artery transplantation; artificial ventilation; cerebrovascular accident (complication); conference paper; descending aorta; disease severity; emergency surgery; female; hemodialysis; human; hypotension (complication); intermethod comparison; lumbar artery; major clinical study; male; paraplegia (complication); postoperative hemorrhage (complication, surgery); priority journal; reoperation; spinal cord injury (complication, epidemiology, etiology); spinal cord ischemia (complication, epidemiology); surgical mortality; surgical technique; tracheostomy; 
EMBASE CLASSIFICATIONS
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002381142
MEDLINE PMID
  12440687 (http://www.ncbi.nlm.nih.gov/pubmed/12440687)
PUI
  L35222725
DOI
  10.1016/S0003-4975(02)04153-X
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-4975(02)04153-X
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2FS0003-4975%2802%2904153-X&atitle=Hypothermic+cardiopulmonary+bypass+and+circulatory+arrest+for+operations+on+the+descending+thoracic+and+thoracoabdominal+aorta&stitle=Ann.+Thorac.+Surg.&title=Annals+of+Thoracic+Surgery&volume=74&issue=5&spage=&epage=&aulast=Kouchoukos&aufirst=Nicholas+T.&auinit=N.T.&aufull=Kouchoukos+N.T.&coden=ATHSA&isbn=&pages=-&date=2002&auinit1=N&auinitm=T
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 933
TITLE
  Surgical tracheostomy versus percutaneous dilational tracheostomy in 
patients with anterior cervical spine fixation: Preliminary report
AUTHOR NAMES
  Šustić A.; Krstulović B.; Eškinja N.; Zelić M.; Ledić D.; Turina D.
AUTHOR ADDRESSES
  (Šustić A., alans@mamed.medri.hr; Krstulović B.; Turina D.) Department of 
Anesthesiology, Intensive Care Unit, University Hospital Rijeka, Croatia.
(Eškinja N.; Ledić D.) Department of Neurosurgery, University Hospital 
Rijeka, Croatia.
(Zelić M.) Department of General Surgery, University Hospital Rijeka, 
Croatia.
(Šustić A., alans@mamed.medri.hr) Dept. of Anesthesiology and ICU, 
University Hospital Rijeka, T. Stri-i a 3, Rijeka 51 000, Croatia.
CORRESPONDENCE ADDRESS
  A. Šustić, Dept. of Anesthesiology, University Hospital Rijeka, T. Stri-i a 
3, Rijeka 51 000, Croatia. Email: alans@mamed.medri.hr
FULL RECORD ENTRY DATE
  2002-09-26
SOURCE
  Spine (2002) 27:17 (1942-1945). Date of Publication: 1 Sep 2002
VOLUME
  27
ISSUE
  17
FIRST PAGE
  1942
LAST PAGE
  1945
DATE OF PUBLICATION
  1 Sep 2002
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Study Design. A prospective, randomized study. Objectives. To compare the 
incidence of perioperative and early postoperative complications of surgical 
tracheostomy (ST) vs. ultrasound-guided percutaneous dilational tracheostomy 
(PDT) in patients with anterior cervical spine fixation (ACSF). Summary of 
Background Data. The patients with ACSF after acute spinal cord injury often 
require tracheostomy. Surgical tracheostomy is burdened with relatively high 
incidence of peristomal infections, and, recently, ultrasound-guided PDT is 
proposed in patients with ACSF. Methods. Sixteen adult patients who 
underwent tracheostomy after acute spinal cord injury and ACSF were 
analyzed. The patients were randomly assigned to two groups: eight patients 
(six males; age range, 24-59 years) who underwent ST and eight patients 
(seven males; age range, 19-47 years) who underwent ultrasound-guided PDT 
with dilatational forceps technique. The incidence of peri- and early 
postoperative complications was followed up, as well as the stoma infections 
and the duration of the procedure. Results. Not one patient from either 
group had any major perioperative complication of tracheostomy. In each 
group, there was one case of prolonged bleeding, which stopped spontaneously 
inside 24 hours. In two patients (25%) from the ST group, purulent infection 
of the stoma was verified during subsequent treatment at an intensive care 
unit. The average time of ST was 21 ± 7 minutes; the average time of 
ultrasound-guided PDT was 8 ± 6 minutes (P < 0.05). Conclusions. Our 
preliminary data demonstrate that ultrasound-guided PDT as regards to 
complications is at least equally safe as ST; at the same time, it is much 
quicker method, probably with less late infections of the stoma, which could 
be an important advantage in patients with ACSF.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; clinical article; clinical trial; controlled clinical trial; controlled study; echography; female; human; intermethod comparison; male; operation duration; postoperative complication; postoperative hemorrhage (complication); postoperative infection (complication); priority journal; randomized controlled trial; spine stabilization; surgical technique; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002325225
MEDLINE PMID
  12221364 (http://www.ncbi.nlm.nih.gov/pubmed/12221364)
PUI
  L35006694
DOI
  10.1097/00007632-200209010-00026
FULL TEXT LINK
  http://dx.doi.org/10.1097/00007632-200209010-00026
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2F00007632-200209010-00026&atitle=Surgical+tracheostomy+versus+percutaneous+dilational+tracheostomy+in+patients+with+anterior+cervical+spine+fixation%3A+Preliminary+report&stitle=Spine&title=Spine&volume=27&issue=17&spage=1942&epage=1945&aulast=%C5%A0usti%C4%87&aufirst=Alan&auinit=A.&aufull=%C5%A0usti%C4%87+A.&coden=SPIND&isbn=&pages=1942-1945&date=2002&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 934
TITLE
  Survival of individuals receiving long-term mechanical ventilation
AUTHOR NAMES
  Langmack E.L.; Make B.J.
AUTHOR ADDRESSES
  (Langmack E.L., langmacke@njc.org; Make B.J.) National Jewish Medical and 
Research Center, 1400 Jackson Street, Denver, CO 80206, United States.
(Langmack E.L., langmacke@njc.org; Make B.J.) Division of Pulmonary Sciences 
and Critical Care Medicine, University of Colorado School of Medicine, 4200 
East 9th Avenue, Denver, CO 80262, United States.
CORRESPONDENCE ADDRESS
  E.L. Langmack, Natl. Jewish Medical/Research Center, 1400 Jackson Street, 
Denver, CO 80206, United States. Email: langmacke@njc.org
FULL RECORD ENTRY DATE
  2002-11-06
SOURCE
  Respiratory Care Clinics of North America (2002) 8:3 (355-377). Date of 
Publication: September 2002
VOLUME
  8
ISSUE
  3
FIRST PAGE
  355
LAST PAGE
  377
DATE OF PUBLICATION
  September 2002
ISSN
  1078-5337
BOOK PUBLISHER
  W.B. Saunders
ABSTRACT
  The reports published to date support the concept that LTMV can extend life 
for patients with respiratory insufficiency, particularly adults and 
children with neuromuscular and chest wall diseases. The impact of LTMV on 
survival in patients with obstructive lung diseases, such as COPD and 
bronchiectasis, is less clear and deserves further study. For all disease 
states, research is needed to determine the characteristics of patients who 
are most likely to benefit from LTMV and whether one method of ventilation 
is superior to another. In addition to survival, other important outcomes, 
such as patient satisfaction, quality of life, and costs associated with 
LTMV, should be assessed in future long-term studies.
EMTREE DRUG INDEX TERMS
  antibiotic agent (drug therapy, pharmacology); corticosteroid (drug therapy); oxygen (drug therapy, inhalational drug administration); riluzole (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; respiratory failure (complication, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis (diagnosis, drug therapy); article; bronchiectasis (drug therapy, epidemiology, therapy); chronic disease; chronic obstructive lung disease (drug therapy, epidemiology, therapy); controlled study; drug efficacy; Duchenne muscular dystrophy (drug therapy, epidemiology); health care cost; human; intermethod comparison; intermittent positive pressure ventilation; interstitial lung disease (therapy); lifespan; long term care; medical research; methodology; morbidity; mortality; neuromuscular disease (diagnosis, drug therapy, therapy); oxygen therapy; patient care; patient satisfaction; poliomyelitis; quality of life; risk factor; spinal cord injury (epidemiology); survival; survival rate; thorax deformity (therapy); tracheostomy; treatment outcome; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
  riluzole (1744-22-5)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
MEDLINE PMID
  12481962 (http://www.ncbi.nlm.nih.gov/pubmed/12481962)
PUI
  L35203400
DOI
  10.1016/S1078-5337(02)00022-9
FULL TEXT LINK
  http://dx.doi.org/10.1016/S1078-5337(02)00022-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10785337&id=doi:10.1016%2FS1078-5337%2802%2900022-9&atitle=Survival+of+individuals+receiving+long-term+mechanical+ventilation&stitle=Respir.+Care+Clin.+North+Am.&title=Respiratory+Care+Clinics+of+North+America&volume=8&issue=3&spage=355&epage=377&aulast=Langmack&aufirst=Esther+L.&auinit=E.L.&aufull=Langmack+E.L.&coden=&isbn=&pages=355-377&date=2002&auinit1=E&auinitm=L
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 935
TITLE
  Self inflicted neck injury with an electric drill
AUTHOR NAMES
  Barnes D.; Clark F.; Baguley P.; Brady N.
AUTHOR ADDRESSES
  (Barnes D., dbarnes.moon@medix-uk.com; Clark F.; Baguley P.; Brady N.) 37 
St. David's Grove, Stockton-on Tees TS17 5HE, United Kingdom.
CORRESPONDENCE ADDRESS
  D. Barnes, 37 St David's Grove, Ingleby Barwick, Stockton-on Tees, United 
Kingdom. Email: dbarnes.moon@medix-uk.com
FULL RECORD ENTRY DATE
  2002-10-15
SOURCE
  Injury (2002) 33:7 (635-638). Date of Publication: September 2002
VOLUME
  33
ISSUE
  7
FIRST PAGE
  635
LAST PAGE
  638
DATE OF PUBLICATION
  September 2002
ISSN
  0020-1383
BOOK PUBLISHER
  Elsevier Ltd, Langford Lane, Kidlington, Oxford, United Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  automutilation; neck injury; 
EMTREE MEDICAL INDEX TERMS
  adult; air conditioning; airway obstruction (diagnosis, surgery); anamnesis; angiography; artery occlusion (diagnosis); article; case report; cervical spine fracture (diagnosis); clinical feature; computer assisted tomography; drill; esophagus injury (diagnosis); human; immobilization; infection; male; neurologic disease (complication); nuclear magnetic resonance imaging; priority journal; risk factor; spinal cord injury (diagnosis); tracheotomy; vertebral artery; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2002350730
MEDLINE PMID
  12208069 (http://www.ncbi.nlm.nih.gov/pubmed/12208069)
PUI
  L35101722
DOI
  10.1016/S0020-1383(01)00170-X
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0020-1383(01)00170-X
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201383&id=doi:10.1016%2FS0020-1383%2801%2900170-X&atitle=Self+inflicted+neck+injury+with+an+electric+drill&stitle=Injury&title=Injury&volume=33&issue=7&spage=635&epage=638&aulast=Barnes&aufirst=D.&auinit=D.&aufull=Barnes+D.&coden=INJUB&isbn=&pages=635-638&date=2002&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 936
TITLE
  Bilateral vocal fold paralysis and adhesion in anterior spinal artery 
syndrome
AUTHOR NAMES
  Omori K.; Isshiki N.; Tsuji T.; Yamashita M.
AUTHOR ADDRESSES
  (Omori K.; Isshiki N.; Tsuji T.; Yamashita M.) Dept. 
Otolaryngology-Head/Neck Surg., Graduate School of Medicine, Kyoto 
University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
CORRESPONDENCE ADDRESS
  K. Omori, Dept. Otolaryngology-Head/Neck Surg., Graduate School of Medicine, 
Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
FULL RECORD ENTRY DATE
  2002-08-27
SOURCE
  Annals of Otology, Rhinology and Laryngology (2002) 111:8 (680-683). Date of 
Publication: 2002
VOLUME
  111
ISSUE
  8
FIRST PAGE
  680
LAST PAGE
  683
DATE OF PUBLICATION
  2002
ISSN
  0003-4894
BOOK PUBLISHER
  Annals Publishing Company, 4507 Laclede Avenue, St. Louis, United States.
ABSTRACT
  The purpose of this report is to present a rare case of anterior spinal 
artery syndrome (ASAS) in which there proved to be a combined lesion of 
paralysis and adhesion. A 26-year-old woman with a history of ASAS 
complained of difficulty of tracheal decannulation. In 1988, she was 
intubated and underwent tracheotomy because of respiratory muscle weakness, 
and she was decannulated in 1990. In 1998, she had cesarean delivery under 
general anesthesia, and postdelivery dyspnea necessitated tracheotomy again. 
On her first visit to us, endoscopic examination revealed bilateral vocal 
fold immobility at the midline without an apparent web. Direct laryngoscopy 
under general anesthesia revealed a posterior glottic adhesion and scarring, 
which were treated by excision of the scar and local steroid injection. The 
left vocal fold gradually regained mobility, permitting decannulation 3 
months after treatment. This complicated vocal fold immobility was found to 
be due to adhesion and partial paralysis combined.
EMTREE DRUG INDEX TERMS
  triamcinolone acetonide (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord ischemia (diagnosis, surgery); vocal cord paralysis (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adhesion; adult; article; breathing muscle; case report; cesarean section; differential diagnosis; dyspnea (complication, surgery); endotracheal intubation; female; general anesthesia; glottis; human; laryngoscopy; muscle weakness (surgery); priority journal; scar formation (complication, diagnosis, drug therapy, surgery); tracheotomy; 
CAS REGISTRY NUMBERS
  triamcinolone acetonide (76-25-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002285420
MEDLINE PMID
  12184587 (http://www.ncbi.nlm.nih.gov/pubmed/12184587)
PUI
  L34864244
DOI
  10.1177/000348940211100804
FULL TEXT LINK
  http://dx.doi.org/10.1177/000348940211100804
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034894&id=doi:10.1177%2F000348940211100804&atitle=Bilateral+vocal+fold+paralysis+and+adhesion+in+anterior+spinal+artery+syndrome&stitle=Ann.+Otol.+Rhinol.+Laryngol.&title=Annals+of+Otology%2C+Rhinology+and+Laryngology&volume=111&issue=8&spage=680&epage=683&aulast=Omori&aufirst=Koichi&auinit=K.&aufull=Omori+K.&coden=AORHA&isbn=&pages=680-683&date=2002&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 937
TITLE
  Continuous noninvasive ventilation for patients with neuromuscular disease 
and spinal cord injury
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Department of Physical Medicine, UMDNJ-New Jersey Medical 
School, University Hospital B-403, 150 Bergen Street, Newark, NJ 07103, 
United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine, UMDNJ-New Jersey Medical School, 
University Hospital B-403, 150 Bergen Street, Newark, NJ 07103, United 
States. Email: bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2002-08-04
SOURCE
  Seminars in Respiratory and Critical Care Medicine (2002) 23:3 (283-292). 
Date of Publication: 2002
VOLUME
  23
ISSUE
  3
FIRST PAGE
  283
LAST PAGE
  292
DATE OF PUBLICATION
  2002
ISSN
  1069-3424
ABSTRACT
  Patients with a variety of neuromuscular diseases including quadraplegia due 
to high spinal cord lesions can be managed with full-time noninvasive 
ventilation instead of intermittent positive pressure ventilation (IPPV) via 
a tracheostomy. This approach is not suitable for patients with severe 
bulbar involvement. To be successful with full-time noninvasive IPPV, the 
ventilator user must realize three goals. First, respiratory system 
compliance should be optimized and maintained by frequent full inflations 
delivered by stacking breaths from a volume-cycled ventilator or by 
insufflating air at adequate pressures using a mechanical 
insufflator-exsufflator. Second, normal levels of alveolar ventilation are 
sustained using a variety of noninvasive approaches, including nasal, 
oronasal, or mouthpiece interfaces. Third, patients must be taught to use 
techniques and devices to enhance cough, particularly the mechanical 
insufflator-exsufflator. When these goals are met, noninvasive NPPV can 
offer patients greater comfort, simpler and more convenient ventilator use, 
and reduced rates of infections, complications, and hospitalizations as 
compared with tracheostomy IPPV.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  assisted ventilation; neuromuscular disease (therapy); spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  breathing muscle; coughing; devices; intermittent positive pressure ventilation; lung compliance; lung ventilation; priority journal; review; tracheostomy; ventilator; 
DEVICE TRADE NAMES
  BiPAP S/T-D  , United StatesRespironics

  Cough Assist  , United StatesEmerson

  Exsufflation Belt  , United StatesRespironics

  Total Face Mask  Respironics

DEVICE MANUFACTURERS
   (United States)Emerson
   (United States)Mallinckrodt
   (France)Masque Buccal
   (United States)Respironics
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002255329
PUI
  L34765067
DOI
  10.1055/s-2002-33037
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-2002-33037
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10693424&id=doi:10.1055%2Fs-2002-33037&atitle=Continuous+noninvasive+ventilation+for+patients+with+neuromuscular+disease+and+spinal+cord+injury&stitle=Semin.+Respir.+Crit.+Care+Med.&title=Seminars+in+Respiratory+and+Critical+Care+Medicine&volume=23&issue=3&spage=283&epage=292&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=SRCCE&isbn=&pages=283-292&date=2002&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 938
TITLE
  Respiratory support in spinal muscular atrophy type I: a survey of physician 
practices and attitudes.
AUTHOR NAMES
  Hardart M.K.; Burns J.P.; Truog R.D.
AUTHOR ADDRESSES
  (Hardart M.K.; Burns J.P.; Truog R.D.) Department of Anesthesia and Critical 
Care, Children's Hospital, Harvard Medical School, Boston, Massachusetts 
02115, USA.
CORRESPONDENCE ADDRESS
  M.K. Hardart, Department of Anesthesia and Critical Care, Children's 
Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. Email: 
kate.hardart@tch.harvard.edu
FULL RECORD ENTRY DATE
  2002-08-06
SOURCE
  Pediatrics (2002) 110:2 Pt 1 (e24). Date of Publication: Aug 2002
VOLUME
  110
ISSUE
  2 Pt 1
DATE OF PUBLICATION
  Aug 2002
ISSN
  1098-4275 (electronic)
ABSTRACT
  OBJECTIVE: To determine whether there is variability in the attitudes and 
practices of physicians regarding treatment of respiratory failure in 
children with spinal muscular atrophy type I (SMA type I) and, if so, 
whether this variation is associated with professional training. METHODS: 
This was a descriptive, cross-sectional survey mailed to a randomly selected 
subset of the Child Neurology Society, pediatric members of the Society of 
Critical Care Medicine and to the membership of the Pediatric Interest 
Section of the American Academy of Physical Medicine and Rehabilitation. A 
scenario of a child with SMA type I in respiratory distress was followed by 
questions that explored practices and attitudes regarding mechanical 
ventilation. RESULTS: Fifty-seven percent of intensivists (75 of 132), 39% 
physiatrists (61 of 155), and 34% of neurologists (61 of 155) responded. 
Specialists differed as to whether they offered and/or recommended 
respiratory support to patients with SMA type I. Intensivists were less 
likely to offer and recommend tracheostomy than physiatrists. Intensivists 
were also significantly less likely than physiatrists to agree with 
statements supporting the ethical necessity of noninvasive mechanical 
ventilation (NIMV) and intubation in the setting of an acute respiratory 
illness, and NIMV and tracheostomy in the setting of chronic respiratory 
failure. Although parallel differences were found between physiatrists and 
neurologists regarding their attitudes toward mechanical ventilation, no 
significant differences were detected between intensivists and neurologists. 
Finally, physicians who reported that a high percentage of their patients 
with SMA type I received "comfort care only" also tended to view mechanical 
ventilation, ie, use of NIMV for chronic respiratory failure, use of 
intubation for an acute respiratory infection, and use of tracheostomy for 
chronic respiratory failure as an unreasonable intervention in most 
circumstances. CONCLUSIONS: We found a wide variation in physician practice 
regarding the mechanical ventilation of patients with SMA type I. This study 
suggests a wide variation not only in what is recommended but also in what 
is actually offered to families of these children. Furthermore, the study 
suggests that physician training and attitudes affect recommendations 
regarding mechanical ventilation and ultimately family decision making.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; clinical practice; hereditary spinal muscular atrophy (complication, therapy); respiratory failure (etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; child; cross-sectional study; health personnel attitude; human; medical ethics; United States; utilization review; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  12165623 (http://www.ncbi.nlm.nih.gov/pubmed/12165623)
PUI
  L35623227
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10984275&id=doi:&atitle=Respiratory+support+in+spinal+muscular+atrophy+type+I%3A+a+survey+of+physician+practices+and+attitudes.&stitle=Pediatrics&title=Pediatrics&volume=110&issue=2+Pt+1&spage=&epage=&aulast=Hardart&aufirst=M+Kathleen+Moynihan&auinit=M.K.&aufull=Hardart+M.K.&coden=&isbn=&pages=-&date=2002&auinit1=M&auinitm=K
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 939
TITLE
  Spinal muscular atrophy type 1: Management and outcomes
AUTHOR NAMES
  Bach J.R.; Baird J.S.; Plosky D.; Navado J.; Weaver B.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu; Plosky D.; Weaver B.) Department of Physical 
Medicine and Rehabilitation, UMDNJ, New Jersey Medical School, Newark, NJ, 
United States.
(Baird J.S.; Navado J.) Department of Pediatrics, UMDNJ, New Jersey Medical 
School, Newark, NJ, United States.
(Bach J.R., bachjr@umdnj.edu) Department of Physical Medicine and 
Rehabilitation, University Hospital B-403, UMDNJ-New Jersey Medical School, 
150 Bergen St., Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Physical Medicine, University Hospital B-403, 
UMDNJ-New Jersey Medical School, 150 Bergen St., Newark, NJ 07103, United 
States. Email: bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2002-07-08
SOURCE
  Pediatric Pulmonology (2002) 34:1 (16-22). Date of Publication: 2002
VOLUME
  34
ISSUE
  1
FIRST PAGE
  16
LAST PAGE
  22
DATE OF PUBLICATION
  2002
ISSN
  8755-6863
BOOK PUBLISHER
  Wiley-Liss Inc., 111 River Street, Hoboken, United States.
ABSTRACT
  Our objectives were to describe survival, hospitalization, speech, and 
outcomes related to respirator needs for spinal muscular atrophy type 1 
(SMA1) patients, using noninvasive or tracheostomy ventilation. From 65 SMA 
patients referred to our clinic since 1996, we chose 56 SMA1 patients who 
developed respiratory failure before age 2 years. Patients either had 
tracheostomy tubes (group A), or used noninvasive ventilation and assisted 
coughing; a previously reported extubation protocol (group B) was used as 
needed. Sixteen patients underwent tracheostomy at 10.8 ± 5.0 months of age, 
33 were in group B, and 7 others died without life-support interventions. 
Compared to group B, group A patients had fewer hospitalizations until age 3 
years, but more after age 5, and 15 of 16 lost all spontaneous breathing 
tolerance posttracheostomy and could not speak. One group A patient died at 
16 months of age, and the others were 73.8 ± 57 months of age (the oldest 
was 19 years old). Two group B patients died at 6 and 13 months, 
respectively, whereas the other 31 were 41.8 ± 26.0 months (and up to 8.3 
years) old. Three of 31 in group B required high-span positive inspiratory 
pressure plus positive end-expiratory pressure (PIP+PEEP) continuously with 
minimal tolerance for breathing on their own, and 4 could not communicate 
verbally. In conclusion, SMA type 1 children can survive beyond 2 years of 
age when offered tracheostomy or noninvasive respiratory support. The latter 
is associated with fewer hospitalizations after age 5 years, freedom from 
daytime ventilator use, and the ability to speak. © 2002 wiley-Liss, Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure (complication, therapy); spinal muscular atrophy (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; artificial ventilation; child; hospitalization; human; infant; major clinical study; outcomes research; priority journal; speech; survival; tracheostomy; ventilator; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002230001
MEDLINE PMID
  12112792 (http://www.ncbi.nlm.nih.gov/pubmed/12112792)
PUI
  L34686706
DOI
  10.1002/ppul.10110
FULL TEXT LINK
  http://dx.doi.org/10.1002/ppul.10110
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=87556863&id=doi:10.1002%2Fppul.10110&atitle=Spinal+muscular+atrophy+type+1%3A+Management+and+outcomes&stitle=Pediatr.+Pulmonol.&title=Pediatric+Pulmonology&volume=34&issue=1&spage=16&epage=22&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=PEPUE&isbn=&pages=16-22&date=2002&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 940
TITLE
  A protocolized approach to pulmonary failure and the role of intermittent 
prone positioning
AUTHOR NAMES
  Michaels A.J.; Wanek S.M.; Dreifuss B.A.; Gish D.M.; Otero D.; Payne R.; Jensen D.H.; Webber C.C.; Long W.B.
AUTHOR ADDRESSES
  (Michaels A.J.; Wanek S.M.; Dreifuss B.A.; Gish D.M.; Otero D.; Payne R.; 
Jensen D.H.; Webber C.C.; Long W.B.) Trauma Services, Legacy Emanuel 
Hospital, 501 North Graham Street, Portland, OR 97227, United States.
CORRESPONDENCE ADDRESS
  A.J. Michaels, Trauma Services, Legacy Emanuel Hospital, 501 North Graham 
Street, Portland, OR 97227, United States. Email: amichael@lhs.org
FULL RECORD ENTRY DATE
  2002-07-04
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2002) 52:6 
(1037-1047). Date of Publication: 2002
VOLUME
  52
ISSUE
  6
FIRST PAGE
  1037
LAST PAGE
  1047
DATE OF PUBLICATION
  2002
ISSN
  1079-6061
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Introduction: We present a series of adult patients treated under a protocol 
for severe lung failure (acute respiratory distress syndrome [ARDS]) that 
uses positive end-expiratory pressure (PEEP) optimization and intermittent 
prone positioning (IPP) to reduce shunt, improve oxygen (O(2)) delivery, and 
reduce Fio(2). Methods: Trauma, emergency vascular, and general surgical 
patients with Pao(2)/Fio(2) (PF) ratio < 200 were entered into a protocol 
designed to maintain mixed venous saturation (Svo(2)) > 70% with Fio(2) < 
0.50. Therapy involved a sequential algorithmic approach that included 
pulmonary artery oximetry, "best-PEEP" determination, optimization of 
cardiac function, limitation of Vo(2), transfusion to hematocrit of 35%, 
frequent bronchoscopy, rational diuresis and, if the Fio(2) was > 0.50, a 
trial of IPP with every-6-hour rotations. Unstable spine fractures and 
pelvic external fixators were the only contraindications to IPP. We 
collected data prospectively and from the charts and trauma registry. 
Results: Forty adults were treated by protocol, 29 were injured and 11 had 
vascular or general surgical primary problems. The patients were 46.3 ± 3.1 
years old (the trauma patients were 42.9 ± 3.2, and the vascular/general 
patients were 62 ± 7.5 years old). Average Injury Severity Score was 25.9 ± 
3.7 and the Murray lung injury score was 2.65 ± 0.9. IPP was used in all 
patients including those with recent tracheostomy, open abdomens, 
laparotomy, thoracotomy, leg external fixators, central nervous system 
injury, continuous venovenous hemofiltration and extracorporeal membrane 
oxygenation cannulae, vasopressor therapy, recent chest wall open reduction 
and internal fixation, and facial fractures. With the initiation of IPP 
therapy, the PF ratio increased from 132.1 ± 8.5 to 231.6 ± 14.2 (p < 
0.001), the Fio(2) was decreased from 65.9 ± 4.0% to 47.0 ± 1.1% (p < 
0.001), and the Svo(2) increased from 75.3 ± 1.8% to 78.6 ± 1.6% (p = 
0.023). PEEP and static compliance were unchanged. The duration of IPP was 
85.6 ± 14.9 hours (median, 55 hours; range, 12 to 490 hours). Within 48 
hours, all patients were on Fio(2) ≤ 0.50. Mortality was 20% (14% for 
trauma) and none died of ARDS. The only complications of IPP were one case 
of partial-thickness skin loss from a malpositioned nasogastric tube and a 
case of transient lingual edema. Conclusion: IPP was independently 
responsible for an increase in PF ratio and SVO(2). We effectively and 
safely used IPP in our patients with ARDS, including many with issues 
generally considered to be contraindications. IPP and best-PEEP therapy 
enabled us to wean all of our patients' Fio(2) to ≤ 0.50 within 48 hours of 
ARDS onset.
EMTREE DRUG INDEX TERMS
  hypertensive agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adult respiratory distress syndrome (therapy); lung insufficiency (therapy); patient positioning; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; blood vessel injury; body position; bronchoscopy; central nervous system disease; clinical article; diuresis; extracorporeal oxygenation; face fracture (surgery); female; heart function; hematocrit; hemofiltration; human; injury; laparotomy; lung compliance; male; mortality; nasogastric tube; open reduction (procedure); osteosynthesis; oximetry; oxygenation; positive end expiratory pressure; priority journal; spine fracture; surgical patient; thoracotomy; tracheotomy; venous oxygen tension; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002222264
MEDLINE PMID
  12045628 (http://www.ncbi.nlm.nih.gov/pubmed/12045628)
PUI
  L34664368
DOI
  10.1097/00005373-200206000-00004
FULL TEXT LINK
  http://dx.doi.org/10.1097/00005373-200206000-00004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10796061&id=doi:10.1097%2F00005373-200206000-00004&atitle=A+protocolized+approach+to+pulmonary+failure+and+the+role+of+intermittent+prone+positioning&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=52&issue=6&spage=1037&epage=1047&aulast=Michaels&aufirst=Andrew+J.&auinit=A.J.&aufull=Michaels+A.J.&coden=JOTRF&isbn=&pages=1037-1047&date=2002&auinit1=A&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 941
TITLE
  An exploration of the occurrence of pressure ulcers in a British spinal 
injuries unit.
AUTHOR NAMES
  Ash D.
AUTHOR ADDRESSES
  (Ash D.) Princess Royal Spinal Injuries Unit, Northern General Hospital, 
Sheffield, UK.
CORRESPONDENCE ADDRESS
  D. Ash, Princess Royal Spinal Injuries Unit, Northern General Hospital, 
Sheffield, UK. Email: david.ash@sth.nhs.uk
FULL RECORD ENTRY DATE
  2002-07-07
SOURCE
  Journal of clinical nursing (2002) 11:4 (470-478). Date of Publication: Jul 
2002
VOLUME
  11
ISSUE
  4
FIRST PAGE
  470
LAST PAGE
  478
DATE OF PUBLICATION
  Jul 2002
ISSN
  0962-1067
ABSTRACT
  Spinal cord injury (SCI) is associated with increased risk of pressure 
ulcers, but there are few published data about this in the United Kingdom 
(UK). This article represents a quantitative exploration of the occurrence 
of pressure ulcers in a UK spinal injuries unit (SIU). The technique used is 
a retrospective review of records: details of 144 completed first admissions 
for SCI between 1998 and 2000 were entered on to a database (SPSS) for 
analysis. Thirty-two per cent of patients already had pressure ulcers on 
admission to the SIU, while a total of 56% experienced an ulcer at some 
stage between injury and discharge from the SIU. Four pressure ulcer risk 
assessment scales were used (Waterlow, Braden, Norton and SCIPUS-A). These 
appeared to have moderate predictive power in this population. Pressure 
ulcers were found to be associated with increased length of hospital stay, 
density of lesion, surgical stabilization of neck injury before transfer to 
the SIU, tracheostomy on admission to the SIU and delayed transfer to the 
SIU after injury. Implications for practice are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  decubitus (epidemiology, etiology); spinal cord injury (complication); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; chi square distribution; child; female; human; incidence; male; middle aged; retrospective study; risk assessment; risk factor; United Kingdom (epidemiology); 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  12100643 (http://www.ncbi.nlm.nih.gov/pubmed/12100643)
PUI
  L35612528
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09621067&id=doi:&atitle=An+exploration+of+the+occurrence+of+pressure+ulcers+in+a+British+spinal+injuries+unit.&stitle=J+Clin+Nurs&title=Journal+of+clinical+nursing&volume=11&issue=4&spage=470&epage=478&aulast=Ash&aufirst=David&auinit=D.&aufull=Ash+D.&coden=&isbn=&pages=470-478&date=2002&auinit1=D&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 942
TITLE
  Myotonia dystrophica and spinal surgery
AUTHOR NAMES
  Colovic V.; Walker R.W.M.
AUTHOR ADDRESSES
  (Colovic V.; Walker R.W.M.) Royal Manchester Children's Hospital, 
Pendlebury, Manchester, United Kingdom.
(Walker R.W.M.) Royal Manchester Children's Hospital, Pendlebury, Manchester 
M27 4HA, United Kingdom.
CORRESPONDENCE ADDRESS
  R.W.M. Walker, Consultant Paediatric Anaesthetist, Royal Manchester 
Children's Hospital, Pendlebury, Manchester M27 4HA, United Kingdom.
FULL RECORD ENTRY DATE
  2002-05-31
SOURCE
  Paediatric Anaesthesia (2002) 12:4 (351-355). Date of Publication: 2002
VOLUME
  12
ISSUE
  4
FIRST PAGE
  351
LAST PAGE
  355
DATE OF PUBLICATION
  2002
ISSN
  1155-5645
BOOK PUBLISHER
  Blackwell Publishing Ltd, 9600 Garsington Road, Oxford, United Kingdom.
ABSTRACT
  Two cases of patients suffering from the congenital form of myotonia 
dystrophica under going spinal surgery are presented. Both patients had 
major complications, including cardiac arrhythmias, postoperative wound 
infection and more minor complications, such as sedation and opioid 
sensitivity. However, the most notable complication resulting in long-term 
morbidity was the deterioration of bulbar muscular function in one of the 
patients. This resulted in recurrent aspiration pneumonia and the need for a 
tracheostomy. This serious complication has not previously been reported 
following surgery.
EMTREE DRUG INDEX TERMS
  adenosine (drug therapy); atracurium besilate (intravenous drug administration, oral drug 
administration); cefotaxime (drug therapy); fentanyl (oral drug administration); midazolam (oral drug administration); morphine; propofol (oral drug administration); sevoflurane; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myotonic dystrophy (congenital disorder, surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; aspiration pneumonia (complication, drug therapy, surgery); case report; clinical examination; clinical feature; debridement; drug sensitivity; female; heart arrhythmia (complication, drug therapy); human; male; muscle function; postoperative complication (complication); postoperative infection (complication, surgery); priority journal; recurrent disease; sedation; spine fusion; Streptococcus pneumonia (complication, drug therapy); tracheostomy; wound dressing; 
CAS REGISTRY NUMBERS
  adenosine (58-61-7)
  atracurium (64228-79-1)
  cefotaxime (63527-52-6, 64485-93-4)
  fentanyl (437-38-7)
  midazolam (59467-70-8)
  morphine (52-26-6, 57-27-2)
  propofol (2078-54-8)
  sevoflurane (28523-86-6)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Anesthesiology (24)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002182130
MEDLINE PMID
  11982844 (http://www.ncbi.nlm.nih.gov/pubmed/11982844)
PUI
  L34534190
DOI
  10.1046/j.1460-9592.2002.00812.x
FULL TEXT LINK
  http://dx.doi.org/10.1046/j.1460-9592.2002.00812.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=11555645&id=doi:10.1046%2Fj.1460-9592.2002.00812.x&atitle=Myotonia+dystrophica+and+spinal+surgery&stitle=Paediatr.+Anaesth.&title=Paediatric+Anaesthesia&volume=12&issue=4&spage=351&epage=355&aulast=Colovic&aufirst=V.&auinit=V.&aufull=Colovic+V.&coden=PAANF&isbn=&pages=351-355&date=2002&auinit1=V&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 943
TITLE
  Impact of respiratory complications on length of stay and hospital costs in 
acute cervical spine injury
AUTHOR NAMES
  Winslow C.; Bode R.K.; Felton D.; Chen D.; Meyer Jr. P.R.
AUTHOR ADDRESSES
  (Winslow C.; Bode R.K.; Felton D.; Chen D.; Meyer Jr. P.R.) Rehabilitation 
Institute of Chicago, 345 East Superior St, Chicago, IL 60611, United 
States.
CORRESPONDENCE ADDRESS
  C. Winslow, Rehabilitation Institute of Chicago, 345 East Superior St, 
Chicago, IL 60611, United States. Email: c-winslow@northwestern.edu
FULL RECORD ENTRY DATE
  2002-05-22
SOURCE
  Chest (2002) 121:5 (1548-1554). Date of Publication: 2002
VOLUME
  121
ISSUE
  5
FIRST PAGE
  1548
LAST PAGE
  1554
DATE OF PUBLICATION
  2002
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Context: Respiratory complications are frequent in patients with acute 
cervical spinal injury (CSI); however, the importance of respiratory 
complications experienced during the initial hospitalization following 
injury is unknown. Objective: To determine if respiratory complications 
experienced during the initial acute-care hospitalization in patients with 
acute traumatic cervical spinal injury (CSI) are more important determinants 
of the length of stay (LOS) and total hospital costs than level of injury. 
Design: A retrospective analysis of an inception cohort for the 5-year 
period from 1993 to 1997. Setting: The Midwest Regional Spinal Cord Injury 
Care System, a model system for CSI, at Northwestern Memorial Hospital, a 
tertiary referral academic medical center. Patients: Four hundred thirteen 
patients admitted with acute CSI and discharged alive. Patients with 
concurrent thoracic injuries were excluded. Main outcome measures: Initial 
acute-care LOS and hospital costs. Results: Both mean LOS and hospital costs 
increased monotonically with the number of respiratory complications 
experienced (p < 0.001, between none and one complication, and between one 
and two complications; p = 0.24 between two and three or more 
complications). A hierarchical regression analysis showed that four 
variables - use of mechanical ventilation, occurrence of pneumonia, need for 
surgery, and use of tracheostomy - explain nearly 60% of the variance in 
both LOS and hospital costs. Each of these variables, when considered 
independently, is a better predictor of hospital costs than level of injury. 
Conclusions: The number of respiratory complications experienced during the 
initial acute-care hospitalization for CSI is a more important determinant 
of LOS and hospital costs than level of injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (disease management, surgery); hospital cost; length of stay; respiratory tract disease (complication, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; controlled study; hospitalization; human; intensive care; major clinical study; pneumonia (complication); prediction; priority journal; regression analysis; retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002172993
MEDLINE PMID
  12006442 (http://www.ncbi.nlm.nih.gov/pubmed/12006442)
PUI
  L34499669
DOI
  10.1378/chest.121.5.1548
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.121.5.1548
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.121.5.1548&atitle=Impact+of+respiratory+complications+on+length+of+stay+and+hospital+costs+in+acute+cervical+spine+injury&stitle=Chest&title=Chest&volume=121&issue=5&spage=1548&epage=1554&aulast=Winslow&aufirst=Christopher&auinit=C.&aufull=Winslow+C.&coden=CHETB&isbn=&pages=1548-1554&date=2002&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 944
TITLE
  Summary statement: nonoperative management and critical care of acute spinal 
cord injury.
AUTHOR NAMES
  Ball P.A.; Nockels R.P.
AUTHOR ADDRESSES
  (Ball P.A.; Nockels R.P.)
CORRESPONDENCE ADDRESS
  P.A. Ball,
FULL RECORD ENTRY DATE
  2002-01-24
SOURCE
  Spine (2001) 26:24 Suppl (S38). Date of Publication: 15 Dec 2001
VOLUME
  26
ISSUE
  24 Suppl
DATE OF PUBLICATION
  15 Dec 2001
ISSN
  0362-2436
EMTREE DRUG INDEX TERMS
  neuroprotective agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; spinal cord injury (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  acute disease; emergency treatment; human; methodology; note; thromboembolism (etiology, prevention); tracheostomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  11805607 (http://www.ncbi.nlm.nih.gov/pubmed/11805607)
PUI
  L35570822
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:&atitle=Summary+statement%3A+nonoperative+management+and+critical+care+of+acute+spinal+cord+injury.&stitle=Spine&title=Spine&volume=26&issue=24+Suppl&spage=&epage=&aulast=Ball&aufirst=P.A.&auinit=P.A.&aufull=Ball+P.A.&coden=&isbn=&pages=-&date=2001&auinit1=P&auinitm=A
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 945
TITLE
  Survival of tetraplegic spinal cord injured persons after the first 
admission of a rehabilitation center and prognosis factors: A multicenter 
study of 697 subjects in French centers
ORIGINAL (NON-ENGLISH) TITLE
  La survie des blessés médullaires tétraplégiques après la première entrée en 
centre de rééducation et ses facteurs pronostiques
AUTHOR NAMES
  Lhéritier K.; Ravaud J.F.; Desert J.F.; Pedelucq J.P.; O'Hanna F.; Daures J.P.
AUTHOR ADDRESSES
  (Lhéritier K.; Ravaud J.F.; Desert J.F.; Pedelucq J.P.; O'Hanna F.; Daures 
J.P.) Lab. d'Epidemiol./Biostatistique, Inst. Univ. de Recherche Clinique, 
641, avenue du doyen Gaston Giraud, 34093 Montpellier, France.
CORRESPONDENCE ADDRESS
  K. Lhéritier, Lab. d'Epidemiol./Biostatistique, Inst. Univ. de Recherche 
Clinique, 641, avenue du doyen Gaston Giraud, 34093 Montpellier, France.
FULL RECORD ENTRY DATE
  2001-12-11
SOURCE
  Revue d'Epidemiologie et de Sante Publique (2001) 49:5 (449-458). Date of 
Publication: 2001
VOLUME
  49
ISSUE
  5
FIRST PAGE
  449
LAST PAGE
  458
DATE OF PUBLICATION
  2001
ISSN
  0398-7620
BOOK PUBLISHER
  Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex, 
France.
ABSTRACT
  Background: We surveyed survival and prognosis factors in tetraplegic spinal 
cord injured persons (TSCI) after their admission to a physical medicine and 
rehabilitation center. Methods: This multicenter study included 697 
individuals, the entire cohort of patients admitted to three of the 
principal French centers caring for spinal cord injured persons from 1949 to 
1997. The data set was drawn from the medical files and included data on the 
accident and its complications, social and demographic features, and the 
characteristics of the spinal injury. Survival data were obtained for all 
subjects from the official registries of their place of birth. Univariate 
(Kaplan-Meier) and multivariate (Cox regression) analysis was made to study 
links between these data and survival. Results : Univariate analysis 
indicated that the principal variables significantly related to survival 
were : level of the lesion, age at the time of the accident, the cause of 
the accident, and the presence of a permanent tracheotomy or a depressive 
syndrome requiring medical care. Multivariate analysis showed that the risk 
of dying was 82 % lower for persons who did not have a permanent 
tracheotomy. The risk declined by 92 %, 89 % and 69 % for TSCI aged 20 years 
or less, 20-39 years and 40-59 years respectively at the time of the 
accident compared with those aged more than 60 years. This risk was 37 % 
lower for TSCI without depressive syndrome and 52 % lower for persons 
injured at levels C6, C7, C8 compared with those injured at levels C2, C3, 
C4. Conclusion : Multivariate analysis showed that the principal prognosis 
factors for survival are the presence of a permanent tracheotomy, the age at 
the time of the accident, the presence of a depressive syndrome and the 
level of the lesion. No statistical improvement of survival was observed 
related with time (corresponding to the year of inclusion) but, over the 
study period, there was an increasing number of spinal cord injured person 
who survived with high lesions.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia (epidemiology); spinal cord injury (epidemiology); 
EMTREE MEDICAL INDEX TERMS
  adult; age; aged; article; depression (epidemiology); female; hospital admission; human; major clinical study; male; multicenter study; prognosis; rehabilitation center; survival; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  2001418181
MEDLINE PMID
  11845094 (http://www.ncbi.nlm.nih.gov/pubmed/11845094)
PUI
  L33097911
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03987620&id=doi:&atitle=Survival+of+tetraplegic+spinal+cord+injured+persons+after+the+first+admission+of+a+rehabilitation+center+and+prognosis+factors%3A+A+multicenter+study+of+697+subjects+in+French+centers&stitle=Rev.+Epidemiol.+Sante+Publ.&title=Revue+d%27Epidemiologie+et+de+Sante+Publique&volume=49&issue=5&spage=449&epage=458&aulast=Lh%C3%A9ritier&aufirst=K.&auinit=K.&aufull=Lh%C3%A9ritier+K.&coden=RESPD&isbn=&pages=449-458&date=2001&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 946
TITLE
  Management of the patient with spinal cord injury
AUTHOR NAMES
  Walker D.A.J.
AUTHOR ADDRESSES
  (Walker D.A.J.) Institute of Neurological Sciences, Southern General 
Hospital, 1345 Govan Road, Glasgow G51 4TF, United Kingdom.
CORRESPONDENCE ADDRESS
  D.A.J. Walker, Institute of Neurological Sciences, Southern General 
Hospital, 1345 Govan Road, Glasgow G51 4TF, United Kingdom.
FULL RECORD ENTRY DATE
  2002-03-20
SOURCE
  Problems in Anesthesia (2001) 13:3 (340-347). Date of Publication: 2001
VOLUME
  13
ISSUE
  3
FIRST PAGE
  340
LAST PAGE
  347
DATE OF PUBLICATION
  2001
ISSN
  0889-4698
ABSTRACT
  Spinal cord injury can be a devastating condition, and because survival is 
now probable, continuing disability remains a major problem. Appreciation of 
some of the mechanisms of secondary injury suggests that both pharmacologic 
and physiologic interventions may reduce morbidity. The anesthesiologist has 
a key role in minimizing secondary ischemic insults to the injured spinal 
cord.
EMTREE DRUG INDEX TERMS
  suxamethonium; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; Doppler ultrasonography; human; hypertension (complication); intubation; laryngoscopy; magnetic resonance angiography; oxygen therapy; paralytic ileus (complication); patient positioning; physiotherapy; respiratory tract disease (complication, surgery, therapy); review; tracheostomy; 
CAS REGISTRY NUMBERS
  suxamethonium (306-40-1, 71-27-2)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2002090339
PUI
  L34202318
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08894698&id=doi:&atitle=Management+of+the+patient+with+spinal+cord+injury&stitle=Probl.+Anesth.&title=Problems+in+Anesthesia&volume=13&issue=3&spage=340&epage=347&aulast=Walker&aufirst=Douglas+A.+J.&auinit=D.A.J.&aufull=Walker+D.A.J.&coden=PRANF&isbn=&pages=340-347&date=2001&auinit1=D&auinitm=A.J.
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 947
TITLE
  An international repatriationof a cervical cord injury patient who was under 
mechanical ventilation
AUTHOR NAMES
  Kamochi M.; Uchida S.; Munaka M.
AUTHOR ADDRESSES
  (Kamochi M.; Uchida S.; Munaka M.) Intensive Care Unit, Yahatanishi-ku, 
Kitakyushu 807-8555, Japan.
CORRESPONDENCE ADDRESS
  M. Kamochi, Intensive Care Unit, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
FULL RECORD ENTRY DATE
  2002-01-16
SOURCE
  Journal of UOEH (2001) 23:4 (443-450). Date of Publication: 1 Dec 2001
VOLUME
  23
ISSUE
  4
FIRST PAGE
  443
LAST PAGE
  450
DATE OF PUBLICATION
  1 Dec 2001
ISSN
  0387-821X
BOOK PUBLISHER
  University of Occupational and Environmental Health, Iseigaoka 1-1, 
Yahata-Nishiku, Kitakyushu, Fukuoka, Japan.
ABSTRACT
  The patient was a 55-year old Japanese man, who had a traffic accident and 
suffered cervical cord injury in Thailand. Although he received an emergency 
operation and intensive care, he had respiratory paralysis and received a 
tracheostomy. One month after the accident, he still needed to receive 
mechanical ventilatory support. He and his wife hoped to return to Japan. We 
were asked to transport the patient from Bangkok to Tokyo. With some help 
from an assistance company, we could transport the patient safely from 
Bangkok to Tokyo on a commercial airline under mechanical ventilatory 
support. We experienced the several regulations and difficulties in 
performing medical treatment and transportation of a critical patient in a 
commercial airline.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adult; aircraft; article; case report; human; male; patient transport; Thailand; traffic accident; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2002014882
MEDLINE PMID
  11789147 (http://www.ncbi.nlm.nih.gov/pubmed/11789147)
PUI
  L34033188
DOI
  10.7888/juoeh.23.443
FULL TEXT LINK
  http://dx.doi.org/10.7888/juoeh.23.443
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0387821X&id=doi:10.7888%2Fjuoeh.23.443&atitle=An+international+repatriationof+a+cervical+cord+injury+patient+who+was+under+mechanical+ventilation&stitle=J.+UOEH&title=Journal+of+UOEH&volume=23&issue=4&spage=443&epage=450&aulast=Kamochi&aufirst=M.&auinit=M.&aufull=Kamochi+M.&coden=JOUOD&isbn=&pages=443-450&date=2001&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 948
TITLE
  Fatal stenosis of trachea and main bronchus due to compression by the spine 
and sternum in three patients with severe motor and intellectual 
disabilities
AUTHOR NAMES
  Tanaka M.; Watanabe Y.; Fukushima K.; Fujiwara T.; Yagi K.; Ohta S.
AUTHOR ADDRESSES
  (Tanaka M.; Watanabe Y.; Fukushima K.; Fujiwara T.; Yagi K.; Ohta S.) 
Departments of Pediatrics, Shizuoka Higashi Hospital, Shizuoka, Japan.
CORRESPONDENCE ADDRESS
  M. Tanaka, Departments of Pediatrics, Shizuoka Higashi Hospital, Shizuoka, 
Japan.
FULL RECORD ENTRY DATE
  2001-07-23
SOURCE
  No To Hattatsu (2001) 33:4 (347-350). Date of Publication: 2001
VOLUME
  33
ISSUE
  4
FIRST PAGE
  347
LAST PAGE
  350
DATE OF PUBLICATION
  2001
ISSN
  0029-0831
BOOK PUBLISHER
  Japanese Society of Child Neurology, 6-13 Wakamatsu-cho, Shinjuku-ku, Tokyo, 
Japan.
ABSTRACT
  Three patients with severe motor and intellectual disabilities developed 
fatal respiratory insufficiencies caused by stenosis of the trachea and main 
bronchus due to compression by the spine and trachea. The onset of 
respiratory insufficiency was by 20, 16, and 29 years of age. Chest computed 
tomography demonstrated deformation and narrowing of the trachea and main 
bronchus, and shortening of the distance between spine and sternum. Although 
respiratory insufficiency was temporarily relieved by insertion of a stent 
into the main bronchus in patient 1, he died at the age of 21 due to 
proliferation of granulation tissue. Patient 2 died of bleeding from the 
granulation tissue around the window of tracheotomy at the age of 18 years, 
and patient 3 died of recurrent pneumonia at the age of 34 years. In 
conclusion, stenosis of the trachea and bronchus observed in these patients 
was caused by progressive deformation of the thorax. The stenosis may result 
in sudden death or recurrent respiratory infections in patients with severe 
motor and intellectual disabilities.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchus stenosis (complication); spinal cord compression; sternum; trachea stenosis (complication); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; bleeding; case report; computer assisted tomography; granulation tissue; human; intellectual impairment; motor dysfunction; pneumonia; respiratory failure (surgery); respiratory tract infection; stent; sudden death; thorax deformity; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2001245757
MEDLINE PMID
  11494579 (http://www.ncbi.nlm.nih.gov/pubmed/11494579)
PUI
  L32634478
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00290831&id=doi:&atitle=Fatal+stenosis+of+trachea+and+main+bronchus+due+to+compression+by+the+spine+and+sternum+in+three+patients+with+severe+motor+and+intellectual+disabilities&stitle=No+To+Hattatsu&title=No+To+Hattatsu&volume=33&issue=4&spage=347&epage=350&aulast=Tanaka&aufirst=M.&auinit=M.&aufull=Tanaka+M.&coden=NTHAA&isbn=&pages=347-350&date=2001&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 949
TITLE
  Survey of children supported by long-term mechanical ventilation in 
Switzerland
AUTHOR NAMES
  Kamm M.; Burger R.; Rimenzsberger P.; Knoblauch A.; Jürg Hammer
AUTHOR ADDRESSES
  (Kamm M.; Burger R.; Rimenzsberger P.; Knoblauch A.; Jürg Hammer) Abt. 
padiatrische Intensivmedizin, Univ.-Kinderspital beider Basel, Postfach, 
CH-4005 Basel, Switzerland.
CORRESPONDENCE ADDRESS
  J. Hammer, Abt. padiatrische Intensivmedizin, Univ.-Kinderspital beider 
Basel, Postfach, CH-4005 Basel, Switzerland. Email: juerg.hammer@unibas.ch
FULL RECORD ENTRY DATE
  2001-07-09
SOURCE
  Swiss Medical Weekly (2001) 131:19-20 (261-266). Date of Publication: 19 May 
2001
VOLUME
  131
ISSUE
  19-20
FIRST PAGE
  261
LAST PAGE
  266
DATE OF PUBLICATION
  19 May 2001
ISSN
  1424-7860
BOOK PUBLISHER
  EMH Swiss Medical Publishers Ltd., Steinentorstrasse 13, Basel, Switzerland.
ABSTRACT
  Objective: The aim of the present study was to identify the number of 
children, from birth to 16 years of age, on long-term mechanical ventilation 
in Switzerland, and to establish their current location, underlying 
diagnoses and ventilatory needs. Methods: Postal questionnaires were sent to 
all chest physicians (pulmonologists), intensive care specialists, 
neurologists, national health care organisations, rehabilitation services 
and ventilator suppliers known or thought to be involved in paediatric 
long-term ventilation in Switzerland. Results: Detailed information was 
obtained on 32 children from 7 centers. Underlying disorders included 
congenital central hypoventilation syndrome (CCHS, 41%), neuromuscular 
disorders (41%), spinal cord injury (6%), craniofacial anomalies (6%) and 
others (6%). 10 children received positive pressure ventilation by 
tracheostomy and 19 children by nasal mask. Two children were ventilated by 
phrenic nerve pacing and one child with the help of a pneumatic belt. 
Children with CCHS were almost equally divided into nasal mask and 
tracheostomy users. Ventilation for 16-24 hours a day was necessary in 5 
children, exclusively during sleep in 24 children and only episodically in 3 
children. All but 2 children were cared for at home. The majority of 
families received home care support. The most common reasons for readmission 
into hospital were regular follow-up examinations and respiratory tract 
infections. The children were mainly admitted to paediatric intensive care 
units. Conclusions: There are few ventilator-supported children in 
Switzerland and most of them are cared for at home. Nevertheless, there is a 
need to establish a system for continuing data collection in this particular 
patient population to assess outcome and quality of home care support and to 
follow incidence trends.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; health survey; home care; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; child; clinical article; health care quality; hospital admission; human; hypoventilation (congenital disorder, therapy); infant; neuromuscular disease (therapy); newborn; outcomes research; phrenic nerve; preschool child; questionnaire; school child; Switzerland; tracheostomy; treatment indication; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Public Health, Social Medicine and Epidemiology (17)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2001225072
MEDLINE PMID
  11452864 (http://www.ncbi.nlm.nih.gov/pubmed/11452864)
PUI
  L32577671
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=14247860&id=doi:&atitle=Survey+of+children+supported+by+long-term+mechanical+ventilation+in+Switzerland&stitle=Swiss+Med.+Wkly&title=Swiss+Medical+Weekly&volume=131&issue=19-20&spage=261&epage=266&aulast=Kamm&aufirst=M.&auinit=M.&aufull=Kamm+M.&coden=SMWWA&isbn=&pages=261-266&date=2001&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 950
TITLE
  Emergency cricothyrotomy: long-term results.
AUTHOR NAMES
  Isaacs Jr. J.H.
AUTHOR ADDRESSES
  (Isaacs Jr. J.H.) Department of Otolaryngology, University of Florida, 
Jacksonville, USA.
CORRESPONDENCE ADDRESS
  J.H. Isaacs, Department of Otolaryngology, University of Florida, 
Jacksonville, USA.
FULL RECORD ENTRY DATE
  2001-04-17
SOURCE
  The American surgeon (2001) 67:4 (346-349; discussion 349-350). Date of 
Publication: Apr 2001
VOLUME
  67
ISSUE
  4
DATE OF PUBLICATION
  Apr 2001
ISSN
  0003-1348
ABSTRACT
  In 1996 we reviewed the literature and reported on our own series of 
emergency cricothyrotomy (EC) patients. The success rate in obtaining an 
airway was very good. The survival rate was also acceptable. However, there 
have been no reports of long-term results of EC. We retrospectively reviewed 
the long-term results in 27 survivors of 65 original EC patients. The 
average length of follow-up was 37 months (1-77 months). In 13 patients no 
airway problems were found. The remaining 14 patients had only minor 
problems such as hoarse voice and mild untreated stenosis. Of these 27 
patients, however, only seven were doing well. Five patients had relatively 
minor problems such as the need for a gastrostomy tube, minor shortness of 
breath, or minor neurological problems. Fifteen patients had major problems: 
cervical spine injuries, changes in mental status, need for permanent 
nursing home care, seizure disorders, or injuries that precluded their 
working. In most cases these problems were due to the underlying disease 
process. EC is effective in obtaining an airway with a low incidence of 
later severe airway problems. However, many of these patients do poorly 
overall.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cricoid cartilage (surgery); critical illness (therapy); emergency treatment (adverse drug reaction); tracheotomy (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; dyspnea (etiology); endotracheal intubation; female; health status; hoarseness (etiology); human; male; methodology; middle aged; mortality; questionnaire; retrospective study; seizure (etiology); survival; trachea stenosis (etiology); treatment outcome; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  11308001 (http://www.ncbi.nlm.nih.gov/pubmed/11308001)
PUI
  L33461512
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00031348&id=doi:&atitle=Emergency+cricothyrotomy%3A+long-term+results.&stitle=Am+Surg&title=The+American+surgeon&volume=67&issue=4&spage=&epage=&aulast=Isaacs+Jr.&aufirst=J.H.&auinit=J.H.&aufull=Isaacs+Jr.+J.H.&coden=&isbn=&pages=-&date=2001&auinit1=J&auinitm=H
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 951
TITLE
  Effect of surgical cricothyrotomy on the unstable cervical spine in a 
cadaver model of intubation
AUTHOR NAMES
  Gerling M.C.; Davis D.P.; Hamilton R.S.; Morris G.F.; Vilke G.M.; Garfin S.R.; Hayden S.R.
AUTHOR ADDRESSES
  (Gerling M.C.) University of California, San Diego School of Medicine, UCSD 
Medical Center, San Diego, CA, United States.
(Davis D.P.; Hamilton R.S.; Vilke G.M.; Hayden S.R.) University of 
California at San Diego Medical Center, Department of Emergency Medicine, 
UCSD Medical Center, San Diego, CA, United States.
(Morris G.F.) University of California, San Diego Medical Center 
Neurosurgery, UCSD Medical Center, San Diego, CA, United States.
(Garfin S.R.) University of California, San Diego Medical Center Orthopedic, 
UCSD Medical Center, San Diego, CA, United States.
(Davis D.P.) UCSD Department of Emergency Medicine, 200 West Arbor Drive, 
#8676, San Diego, CA 92103, United States.
CORRESPONDENCE ADDRESS
  D.P. Davis, Department of Emergency Medicine, UCSD, 200 West Arbor Drive, 
San Diego, CA 92103, United States.
FULL RECORD ENTRY DATE
  2001-02-15
SOURCE
  Journal of Emergency Medicine (2001) 20:1 (1-5). Date of Publication: 2001
VOLUME
  20
ISSUE
  1
FIRST PAGE
  1
LAST PAGE
  5
DATE OF PUBLICATION
  2001
ISSN
  0736-4679
BOOK PUBLISHER
  Elsevier USA, 6277 Sea Harbor Drive, Orlando, United States.
ABSTRACT
  Cricothyrotomy is indicated for patients who require an immediate airway and 
in whom orotracheal or nasotracheal intubation is unsuccessful or 
contraindicated. Cricothyrotomy is considered safe with cervical spine 
(c-spine) injury; however, the amount of c-spine movement that occurs during 
the procedure has not been determined. In this experimental study, an 
established cadaver model of c-spine injury was used to quantify movement 
during cricothyrotomy. A complete C5-6 transection was performed by using an 
osteotome on 13 fresh-frozen cadavers. Standard open cricothyrotomy was 
performed on each cadaver, with c-spine images recorded in real time on 
fluoroscopy, then transferred to video and Kodachrome still images. Outcome 
measures included movement across the C5-6 site with regard to angulation 
expressed in degrees of rotation and linear measures of axial distraction 
and anterior-posterior (AP) displacement expressed as a proportion of C5 
body width. Data were analyzed by using descriptive statistics to determine 
mean change from baseline in each of three planes of movement. Significance 
was assumed if 95% confidence intervals did not include zero. A significant 
amount of movement was observed with regard to AP displacement (6.3% of C5 
width) and axial distraction (-4.5% of C5 width, indicating narrowing of the 
intervertebral space). These correspond to 1-2 mm AP displacement and less 
than 1 mm axial compression. No significant angular displacement was 
observed. In conclusion, cricothyrotomy results in a small but significant 
amount of movement across an unstable c-spine injury in a cadaver model. 
This degree of movement is less than the threshold for clinical 
significance. Copyright © 2001 Elsevier Science Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency treatment; spine injury; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  article; cadaver; cervical spine; human; human tissue; model; priority journal; spinal cord injury; spine stabilization; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2001046800
MEDLINE PMID
  11165829 (http://www.ncbi.nlm.nih.gov/pubmed/11165829)
PUI
  L32112040
DOI
  10.1016/S0736-4679(00)00287-0
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0736-4679(00)00287-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07364679&id=doi:10.1016%2FS0736-4679%2800%2900287-0&atitle=Effect+of+surgical+cricothyrotomy+on+the+unstable+cervical+spine+in+a+cadaver+model+of+intubation&stitle=J.+Emerg.+Med.&title=Journal+of+Emergency+Medicine&volume=20&issue=1&spage=1&epage=5&aulast=Gerling&aufirst=Michael+C&auinit=M.C.&aufull=Gerling+M.C.&coden=JEMMD&isbn=&pages=1-5&date=2001&auinit1=M&auinitm=C
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 952
TITLE
  Trauma airway management
AUTHOR NAMES
  Langeron O.
AUTHOR ADDRESSES
  (Langeron O.) Departement d'Anesthesie-Reanimation, Hopital de la 
Pitie-Salpetriere, 47 Boulevard de l'Hopital, 75651 Paris Cedex 13, France.
CORRESPONDENCE ADDRESS
  O. Langeron, Departement d'Anesthesie-Reanimation, Hopital de la 
Pitie-Salpetriere, 47 Boulevard de l'Hopital, 75651 Paris Cedex 13, France. 
Email: olivier.langeron@psl.ap-hop-paris.fr
FULL RECORD ENTRY DATE
  2001-01-02
SOURCE
  Current Opinion in Critical Care (2000) 6:6 (383-389). Date of Publication: 
2000
VOLUME
  6
ISSUE
  6
FIRST PAGE
  383
LAST PAGE
  389
DATE OF PUBLICATION
  2000
ISSN
  1070-5295
ABSTRACT
  Maintenance of a patent and secured airway is essential to the management of 
trauma, and requires physicians experienced with airway control techniques. 
Trauma-setting airway control problems can be caused by vital failures, risk 
of aspiration, potential for cervical spine injury, combative patients, and 
the obvious risk of difficult tracheal intubation related to the specific 
injury of the patient. Endotracheal intubation remains the gold standard in 
airway management for trauma patients, and should be performed via the oral 
route, with a rapid sequence induction and a manual in-line stabilization 
maneuver, to circumvent some of the problems previously mentioned. In this 
paper different techniques to control the airway in trauma patients are 
discussed, including lighted stylet tracheal intubation, improvement of the 
laryngoscopic vision, retrograde technique for orotracheal intubation, the 
laryngeal mask and the intubating laryngeal mask airways, the combitube, and 
cricothyroidotomy. Airway management in trauma patients requires regular 
training in these techniques, and knowledge of complementary techniques that 
allow tracheal intubation or oxygenation to overcome difficult intubation is 
vitally important. (C) 2000 Lippincott Williams and Wilkins, Inc.
EMTREE DRUG INDEX TERMS
  oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endotracheal intubation; first aid; lung clearance; traumatology; 
EMTREE MEDICAL INDEX TERMS
  anesthesia induction; aspiration; cervical spine injury (complication); human; laryngeal mask; laryngoscopy; oxygenation; patient attitude; procedures; review; risk factor; tracheotomy; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000435330
PUI
  L30995723
DOI
  10.1097/00075198-200012000-00002
FULL TEXT LINK
  http://dx.doi.org/10.1097/00075198-200012000-00002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10705295&id=doi:10.1097%2F00075198-200012000-00002&atitle=Trauma+airway+management&stitle=Curr.+Opin.+Crit.+Care&title=Current+Opinion+in+Critical+Care&volume=6&issue=6&spage=383&epage=389&aulast=Langeron&aufirst=O.&auinit=O.&aufull=Langeron+O.&coden=COCCF&isbn=&pages=383-389&date=2000&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 953
TITLE
  Sevoflurane mask anesthesia for urgent tracheostomy in an uncooperative 
trauma patient with a difficult airway
AUTHOR NAMES
  Smith C.E.; Fallon W.F. Jr.
AUTHOR ADDRESSES
  (Smith C.E.; Fallon W.F. Jr.) Department of Anesthesiology, MetroHealth 
Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, United States.
CORRESPONDENCE ADDRESS
  C.E. Smith, Department of Anesthesiology, MetroHealth Medical Center, 2500 
MetroHealth Drive, Cleveland, OH 44109, United States. Email: 
ces4@po.cwru.edu
FULL RECORD ENTRY DATE
  2000-11-27
SOURCE
  Canadian Journal of Anesthesia (2000) 47:3 (242-245). Date of Publication: 
2000
VOLUME
  47
ISSUE
  3
FIRST PAGE
  242
LAST PAGE
  245
DATE OF PUBLICATION
  2000
ISSN
  0832-610X
BOOK PUBLISHER
  Canadian Anaesthetists' Society, 1 Eglinton Avenue East, Suite 208, Toronto, 
Canada.
ABSTRACT
  Purpose: Proper care of the trauma patient often includes tracheal 
intubation to insure adequate ventilation and oxygenation, protect the 
airway from aspiration, and facilitate surgery. Airway management can be 
particularly complex when there are facial bone fractures, head injury and 
cervical spine instability. Clinical Features: A 29-yr-old intoxicated woman 
suffered a motor vehicle accident. Injuries consisted of multiple abrasions 
to her head, forehead, and face, right temporal lobe hemorrhage, and complex 
mandibular fractures with displacement. Mouth opening was < 10 mm. Blood 
pressure was 106/71 mmHg, pulse 109, respirations 18, temperature 37.3°C, 
SpO(2) 100%. Chest and pelvic radiographs were normal and the there was 
increased anterior angulation of C4-C5 on the cervical spine film. Drug 
screen was positive for cocaine and alcohol. The initial plan was to perform 
awake tracheostomy with local anesthesia. However, the patient was 
uncooperative despite sedation and infiltration of local anesthesia. 
Sevoflurane, 1%, inspired in oxygen 100%, was administered via face mask. 
The concentration of sevoflurane was gradually increased to 4%, and loss of 
consciousness occurred within one minute. The patient breathed spontaneously 
and required gentle chin lift and jaw thrust. A cuffed tracheostomy tube was 
surgically inserted without complication. Blood gas showed pH 7.40, PCO(2) 
35 mmHg, PO(2) 396 mmHg, hematocrit 33.6%. Diagnostic peritoneal lavage was 
negative. Pulmonary aspiration did not occur. Oxygenation and ventilation 
were maintained throughout the procedure. Conclusion: Continuous mask 
ventilation with sevoflurane is an appropriate technique when confronted 
with an uncooperative trauma patient with a difficult airway.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  sevoflurane (inhalational drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  inhalation anesthesia; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; breathing; case report; cervical spine injury; clinical feature; consciousness; endotracheal intubation; face fracture; face mask; female; head injury; human; oxygenation; priority journal; 
CAS REGISTRY NUMBERS
  sevoflurane (28523-86-6)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  2000398615
MEDLINE PMID
  10730735 (http://www.ncbi.nlm.nih.gov/pubmed/10730735)
PUI
  L30827881
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0832610X&id=doi:&atitle=Sevoflurane+mask+anesthesia+for+urgent+tracheostomy+in+an+uncooperative+trauma+patient+with+a+difficult+airway&stitle=Can.+J.+Anesth.&title=Canadian+Journal+of+Anesthesia&volume=47&issue=3&spage=242&epage=245&aulast=Smith&aufirst=C.E.&auinit=C.E.&aufull=Smith+C.E.&coden=CJOAE&isbn=&pages=242-245&date=2000&auinit1=C&auinitm=E
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 954
TITLE
  Cervical spine clearance and neck extension during percutaneous tracheostomy 
in trauma patients
AUTHOR NAMES
  Mayberry J.C.; Wu I.C.; Goldman R.K.; Chesnut R.M.
AUTHOR ADDRESSES
  (Mayberry J.C.; Wu I.C.; Goldman R.K.) Department of Surgery, Oregon Health 
Sciences University, Portland, OR, United States.
(Chesnut R.M.) Department of Neurosurgery, Oregon Health Sciences 
University, Portland, OR, United States.
(Mayberry J.C.) Department of Surgery, 3181 SW Sam Jackson Park Road, 
Portland, OR 97201-3098, United States.
CORRESPONDENCE ADDRESS
  J.C. Mayberry, Department of Surgery, 3181 SW Sam Jackson Park Road, 
Portland, OR 97201-3098, United States.
FULL RECORD ENTRY DATE
  2000-11-16
SOURCE
  Critical Care Medicine (2000) 28:10 (3436-3440). Date of Publication: 2000
VOLUME
  28
ISSUE
  10
FIRST PAGE
  3436
LAST PAGE
  3440
DATE OF PUBLICATION
  2000
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Introduction: The lack of cervical spine clearance and inability to extend 
the neck are assumed to be relative contraindications for percutanecus 
tracheostomy. Objective: To determine the necessity of cervical spine 
clearance and neck extension in trauma patients receiving percutaneous 
tracheostomy. Design: Prospective analysis of case series from August 1, 
1995 to August 31, 1998. Setting: A university-based Level I trauma center. 
Patients: A total of 88 consecutive trauma patients receiving percutaneous 
tracheostomy. Patients were divided into two groups based on the 
radiographic or clinical status of their cervical spine: cleared and 
noncleared. Results: The overall success and complication rate were 99% 
(87/88) and 11% (10/88), respectively. There were no procedure-related 
deaths. The cleared group consisted of 60 patients; three patients in this 
group who had 'bull' or 'thick' necks did not have full neck extension 
during percutaneous tracheostomy. The noncleared group consisted of 28 
patients, 13 of which had known cervical spine fractures; 27 noncleared 
patients were maintained in the neutral positron (no extension) during 
percutaneous tracheostomy, whereas one patient with low suspicion of spinal 
injury was partially extended. Of the 13 patients with cervical spine 
fractures, six patients had been stabilized with a halo or operative 
fixation, and seven patients were stabilized with a cervical collar at the 
time of percutaneous tracheostomy. The success rate was 100% (60/60) for the 
cleared group compared with 96% (27/28) for the noncleared group (p > .05). 
The complication rate was 13% (8/60) for the cleared group compared with 
7.1% (2/28) for the noncleared group (p > .05). We had a 100% success rate 
and no complications in the seven patients with cervical spine injury who 
were stabilized with a cervical collar. No patient had spinal cord injury 
caused by percutaneous tracheostomy. Conclusion: Percutaneous tracheostomy 
can be safely performed in trauma patients without cervical spine clearance 
and neck extension, including patients with stabilized cervical spine or 
spinal cord injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; neck injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; brace; cervical spine fracture; female; human; major clinical study; male; priority journal; spine instability; spine stabilization; treatment outcome; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000375860
MEDLINE PMID
  11057798 (http://www.ncbi.nlm.nih.gov/pubmed/11057798)
PUI
  L30792364
DOI
  10.1097/00003246-200010000-00011
FULL TEXT LINK
  http://dx.doi.org/10.1097/00003246-200010000-00011
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F00003246-200010000-00011&atitle=Cervical+spine+clearance+and+neck+extension+during+percutaneous+tracheostomy+in+trauma+patients&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=28&issue=10&spage=3436&epage=3440&aulast=Mayberry&aufirst=John+C.&auinit=J.C.&aufull=Mayberry+J.C.&coden=CCMDC&isbn=&pages=3436-3440&date=2000&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 955
TITLE
  Percutaneous tracheostomy in patients without cervical spine clearance
AUTHOR NAMES
  Scalea T.M.
AUTHOR ADDRESSES
  (Scalea T.M.) Univ. of Maryland School of Medicine, R. Adams Cowley Shock 
Trauma Center, Baltimore, MD, United States.
CORRESPONDENCE ADDRESS
  T.M. Scalea, Univ. of Maryland School of Medicine, R. Adams Cowley Shock 
Trauma Center, Baltimore, MD, United States.
FULL RECORD ENTRY DATE
  2000-11-16
SOURCE
  Critical Care Medicine (2000) 28:10 (3566-3567). Date of Publication: 2000
VOLUME
  28
ISSUE
  10
FIRST PAGE
  3566
LAST PAGE
  3567
DATE OF PUBLICATION
  2000
ISSN
  0090-3493
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (disease management); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; body position; editorial; health care cost; human; intensive care; postoperative complication; priority journal; spine instability; surgical technique; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Anesthesiology (24)
  Health Policy, Economics and Management (36)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2000375883
MEDLINE PMID
  11057821 (http://www.ncbi.nlm.nih.gov/pubmed/11057821)
PUI
  L30792387
DOI
  10.1097/00003246-200010000-00042
FULL TEXT LINK
  http://dx.doi.org/10.1097/00003246-200010000-00042
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903493&id=doi:10.1097%2F00003246-200010000-00042&atitle=Percutaneous+tracheostomy+in+patients+without+cervical+spine+clearance&stitle=Crit.+Care+Med.&title=Critical+Care+Medicine&volume=28&issue=10&spage=3566&epage=3567&aulast=Scalea&aufirst=T.M.&auinit=T.M.&aufull=Scalea+T.M.&coden=CCMDC&isbn=&pages=3566-3567&date=2000&auinit1=T&auinitm=M
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 956
TITLE
  Anesthesia for a cervical myelopathy patient with tracheal stenosis
AUTHOR NAMES
  Yamada K.; Nishiyama T.; Hanaoka K.
AUTHOR ADDRESSES
  (Yamada K.; Nishiyama T.; Hanaoka K.) Department of Anesthesiology, Faculty 
of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
CORRESPONDENCE ADDRESS
  K. Yamada, Department of Anesthesiology, Faculty of Medicine, University of 
Tokyo, Tokyo 113-8655, Japan.
FULL RECORD ENTRY DATE
  2000-10-20
SOURCE
  Japanese Journal of Anesthesiology (2000) 49:9 (1030-1032). Date of 
Publication: 2000
VOLUME
  49
ISSUE
  9
FIRST PAGE
  1030
LAST PAGE
  1032
DATE OF PUBLICATION
  2000
ISSN
  0021-4892
BOOK PUBLISHER
  Kokuseido Publishing Co. Ltd, 23-5-202 Hongo, 3-chome, Bunkyo-ku, Tokyo, 
Japan.
ABSTRACT
  A 71-year-old male with cervical myelopathy was scheduled for C 3-7 
laminectomy. Once he had been rejected of general anesthesia in other 
hospital because of his tracheal stenosis. The diameter of the narrowest 
part of his trachea was 5 mm probably resulting from tracheostomy at 2 years 
of age. His cervical myelopathy seemed to be no problem for anesthesia 
induction because he had no problems in his neck movement and opening mouth. 
We evaluated his tracheal stenosis carefully using bronchofiberscopy, chest 
X-ray, computed tomography and pulmonary function tests. After intravenous 
fentanyl 100 μg and midazolam 2.5 mg, it was impossible to ventilate the 
patient. Therefore, tracheal intubation was performed immediately after 
lidocaine administration into the trachea. During surgery, tracheal tube 
dilated the narrowed portion. After surgery, the tracheal tube was removed 
under bronchofiberscopic observation without any problems. Tracheal stenosis 
was observed by chest X-ray after surgery, but he had no complaints.
EMTREE DRUG INDEX TERMS
  fentanyl derivative (intravenous drug administration); midazolam (intravenous drug administration); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical myelopathy (surgery); trachea stenosis (diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; anesthesia induction; article; case report; computer assisted tomography; endotracheal intubation; endotracheal tube; fiberoptic bronchoscopy; general anesthesia; human; laminectomy; lung function test; male; mouth; movement (physiology); neck; thorax radiography; tracheostomy; 
CAS REGISTRY NUMBERS
  midazolam (59467-70-8)
EMBASE CLASSIFICATIONS
  Surgery (9)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  2000351414
MEDLINE PMID
  11025963 (http://www.ncbi.nlm.nih.gov/pubmed/11025963)
PUI
  L30745042
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00214892&id=doi:&atitle=Anesthesia+for+a+cervical+myelopathy+patient+with+tracheal+stenosis&stitle=Jpn.+J.+Anesthesiol.&title=Japanese+Journal+of+Anesthesiology&volume=49&issue=9&spage=1030&epage=1032&aulast=Yamada&aufirst=K.&auinit=K.&aufull=Yamada+K.&coden=MASUA&isbn=&pages=1030-1032&date=2000&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 957
TITLE
  Weaning injured patients with prolonged pulmonary failure from mechanical 
ventilation in a non-intensive care unit setting
AUTHOR NAMES
  DeBoisblanc M.W.; Goldman R.K.; Mayberry J.C.; Brand D.M.; Pangburn P.D.; Soifer B.E.; Mullins R.J.
AUTHOR ADDRESSES
  (DeBoisblanc M.W.; Goldman R.K.; Mayberry J.C.; Brand D.M.; Mullins R.J.) 
Department of Surgery, Oregon Health Sciences University, Portland, OR, 
United States.
(Soifer B.E.) Department of Anesthesiology, Oregon Health Sciences 
University, Portland, OR, United States.
(Pangburn P.D.) Department of Respiratory Care, Oregon Health Sciences 
University, Portland, OR, United States.
(Goldman R.K.) Oregon Health Sciences University L223A, 3181 S. W. Sam 
Jackson Park Road, Portland, OR 97201-3098, United States.
CORRESPONDENCE ADDRESS
  R.K. Goldman, Oregon Hlth. Sci. University L223A, 3181 S. W. Sam Jackson 
Park Road, Portland, OR 97201-3098, United States.
FULL RECORD ENTRY DATE
  2000-09-25
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (2000) 49:2 
(224-231). Date of Publication: 2000
VOLUME
  49
ISSUE
  2
FIRST PAGE
  224
LAST PAGE
  231
DATE OF PUBLICATION
  2000
ISSN
  1079-6061
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Background: Injured patients with pulmonary failure often require prolonged 
length of stay in an intensive care unit (ICU), which includes weaning from 
ventilatory support. In the last decade, noninvasive ventilation modes have 
been established as safe and effective. One method for accomplishing this 
mode of ventilation uses a simple bilevel ventilator. Because this 
ventilator has been successfully used in hospital wards, we postulated that 
bilevel ventilators could provide sufficient support during weaning from 
mechanical ventilation of injured patients in a non-ICU setting. Methods: A 
retrospective review of trauma patients (August 1996-January 1999) 
undergoing bilevel positive pressure ventilation as the final phase of 
weaning was conducted. Before ward transfer with bilevel ventilation, 
conventionally ventilated ICU patients were changed to bilevel ventilation 
and were required to tolerate this mode for at least 24 hours. All patients 
had a tracheostomy as a secure airway. Outcomes analyzed included ICU length 
of stay, hospital length of stay, duration of mechanical ventilation, 
weaning success, complications, and survival. Results: Fifty-one patients 
(39 men, 12 women) with a mean age of 53 received more than 24 hours of 
bilevel positive pressure ventilation. Mean Injury Severity Score was 29, 
with blunt mechanisms of injury occurring in 90%. Chest or spinal cord 
injuries that affected pulmonary mechanics were present in 75% of patients. 
Ventilator-associated pneumonia was treated in 43% of patients. Mean ICU 
length of stay and hospital length of stay were 21 and 34 days, 
respectively. Weaning was successful in 89% of patients, whereas 11% were 
discharged to skilled nursing facilities still receiving bilevel positive 
pressure ventilation. Two patients died, neither from a pulmonary nor airway 
complication. Of the remaining 49 patients, 12 were weaned in the ICU and 37 
were transferred to the ward with bilevel ventilatory support. The average 
length of ward ventilation was 6.5 ± 5.4 days (n = 37). Conclusions: 
Implementation of a program using bilevel ventilation to support the 
terminal phase of weaning seriously injured patients from mechanical 
ventilation was successful. After initiating this mode in the ICU, it was 
satisfactorily continued in standard surgical wards. Because this method 
enabled the withdrawal of ventilatory support in a non-ICU setting, its 
major advantage was reducing ICU length of stay.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; lung insufficiency (therapy); multiple trauma; 
EMTREE MEDICAL INDEX TERMS
  adult; conference paper; disease severity; female; hospitalization; human; injury scale; intensive care unit; major clinical study; male; pneumonia (complication); positive end expiratory pressure; priority journal; tracheostomy; treatment outcome; weaning; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000321336
MEDLINE PMID
  10963532 (http://www.ncbi.nlm.nih.gov/pubmed/10963532)
PUI
  L30687942
DOI
  10.1097/00005373-200008000-00007
FULL TEXT LINK
  http://dx.doi.org/10.1097/00005373-200008000-00007
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10796061&id=doi:10.1097%2F00005373-200008000-00007&atitle=Weaning+injured+patients+with+prolonged+pulmonary+failure+from+mechanical+ventilation+in+a+non-intensive+care+unit+setting&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=49&issue=2&spage=224&epage=231&aulast=DeBoisblanc&aufirst=Michael+W.&auinit=M.W.&aufull=DeBoisblanc+M.W.&coden=JOTRF&isbn=&pages=224-231&date=2000&auinit1=M&auinitm=W
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 958
TITLE
  Forced oscillation technique to detect and monitor tracheal stenosis in a 
tetraplegic patient
AUTHOR NAMES
  Beraldo P.S.S.; Mateus S.R.M.; Araujo L.M.; Horan T.A.
AUTHOR ADDRESSES
  (Beraldo P.S.S.; Mateus S.R.M.; Araujo L.M.; Horan T.A.) AOS 04, Bloc C, 
apto 106, 70, 660-043 Brasilia/DF, Brazil.
CORRESPONDENCE ADDRESS
  P.S.S. Beraldo, AOS 04, Bloc C, apto 106, 70, 660-043 Brasilia/DF, Brazil.
FULL RECORD ENTRY DATE
  2000-09-10
SOURCE
  Spinal Cord (2000) 38:7 (445-447). Date of Publication: 2000
VOLUME
  38
ISSUE
  7
FIRST PAGE
  445
LAST PAGE
  447
DATE OF PUBLICATION
  2000
ISSN
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Study design: A case report. Objectives: To demonstrate forced oscillation 
technique's (FOT) utility in a tetraplegic patient with tracheostenosis. 
Setting: A Rehabilitation Hospital, Brasilia, Brazil. Methods: Serial 
evaluations of spirometry, bronchoscopy and forced oscillation assessment. 
Results: A 16-year-old male with C7 spinal cord injury, initially required 
mechanical ventilation and subsequent tracheostomy over a period of 4 weeks. 
Five months after the accident the onset of tracheostenosis was diagnosed. 
Flow-volume data were compatible with a fixed tracheal stenosis. FOT showed 
an obstructed pattern, manifested by high levels of resonance frequency and 
impedance. The FOT pattern returned to normal after dilatation. The FOT 
abnormalities recurred with two subsequent broncoscopicaly confirmed 
episodes of tracheal restenosis without parallel changes in spirometric 
parameters. Conclusion: This case suggests a role for FOT in the non 
invasive detection and follow up of tracheal stenosis. FOT may be 
particularly useful in tetraplegic patients, in whom the restriction from 
muscle weakness may make interpretation of forced expiratory flow-volume 
data problematic.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia; trachea stenosis (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; case report; diagnostic procedure; forced expiratory volume; human; male; muscle weakness; oscillation; patient monitoring; priority journal; spinal cord injury; trachea obstruction; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000301888
MEDLINE PMID
  10962606 (http://www.ncbi.nlm.nih.gov/pubmed/10962606)
PUI
  L30655832
DOI
  10.1038/sj.sc.3101005
FULL TEXT LINK
  http://dx.doi.org/10.1038/sj.sc.3101005
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsj.sc.3101005&atitle=Forced+oscillation+technique+to+detect+and+monitor+tracheal+stenosis+in+a+tetraplegic+patient&stitle=Spinal+Cord&title=Spinal+Cord&volume=38&issue=7&spage=445&epage=447&aulast=Beraldo&aufirst=P.S.S.&auinit=P.S.S.&aufull=Beraldo+P.S.S.&coden=SPCOF&isbn=&pages=445-447&date=2000&auinit1=P&auinitm=S.S.
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 959
TITLE
  A 67-year-old man with progressive disturbance of gait
AUTHOR NAMES
  Sato K.-I.; Sato S.; Ohta S.; Mori H.; Matsuoka S.; Shirai T.; Kanazaea A.; Mizuno Y.
AUTHOR ADDRESSES
  (Sato K.-I.; Sato S.; Ohta S.; Mori H.; Matsuoka S.; Shirai T.; Kanazaea A.; 
Mizuno Y.) Juntendo Univ. School of Medicine, Department of Neurology, 2-1-1 
Hongo, Bunkyo, Tokyo 113-8421, Japan.
CORRESPONDENCE ADDRESS
  Y. Mizuno, Juntendo Univ. School of Medicine, Department of Neurology, 2-1-1 
Hongo, Bunkyo, Tokyo 113-8421, Japan.
FULL RECORD ENTRY DATE
  2000-08-28
SOURCE
  Brain and Nerve (2000) 52:7 (643-653). Date of Publication: 2000
VOLUME
  52
ISSUE
  7
FIRST PAGE
  643
LAST PAGE
  653
DATE OF PUBLICATION
  2000
ISSN
  0006-8969
BOOK PUBLISHER
  Igaku-Shoin Ltd, 5-24-3 Hongo, Bunkyo-ku, Tokyo, Japan.
ABSTRACT
  We report a 67-year-old man with progressive disturbance of gait. He was 
well until the spring of 1993 (62 years of the age), when he noted an onset 
of unsteady gait. He also noted that he started to have a difficulty in 
playing tennis, in which he became unable to hit the ball with his racket. 
He also noted parkinsonian features such as bradykinesia and loss of hand 
dexterity. He was treated with levodopa, which did not improve his symptoms. 
His MRI revealed marked atrophy of the cerebellum and the pons. The 
criss-cross high signal lesion was seen in the center of the pons. The third 
ventricle was dilated. The putamen was unremarkable. His subsequent course 
was complicated by easy to fall, difficulty in swallowing with episodes of 
aspiration pneumonia. He also developed nocturnal apneustic episodes. He was 
admitted to our hospital on November 15, 1998, when he was 67 years of the 
age. He had low grade fever and low blood pressure (98/70). He was anemic 
but not icteric. Tumors were palpated in his jaw, anterior chest, and in the 
left arm. He was alert but unable to convey his desire because of dyspnea 
and tracheostomy. His gaze was slightly restricted in the horizontal 
direction and markedly so in the vertical direction. Motor functions were 
difficult to evaluate. His clinical course was complicated by atelectasis of 
the fight lung and pleural effusion. He developed marked edema and oliguria. 
He developed sudden bradycardia and expired on December 26, 1998. He was 
discussed in a neurological CPC and the chief discussant arrived at the 
conclusion that the patient had multiple system atrophy. Majority of the 
audience agreed with this diagnosis. Post-mortem examination revealed a lung 
cancer in the right lung(undifferentiated adenocarcinoma) with metastases to 
the liver, kidneys, lymph nodes, pericardium, pleura, skin, bone marrow, and 
the brain. Neuropathologic examination revealed marked atrophy of the pons 
and the cerebellum. The putamen showed brownish discoloration and atrophic 
changes. The substantia nigra showed marked neuronal loss and gliosis. 
Oligodendrocytic inclusion bodies (alpha-synuclein positive) were seen in 
the putamen, globus pallidus, substantia nigra, pontine nucleus, cerebellar 
white matter, internal capsule, cerebral peduncle, and the spinal cord. 
These findings are consistent with the pathologic diagnosis of multiple 
system atrophy. What was interesting to us was the presence of 
neurofibrillary tangles in the substantia nigra, nucleus ruber, globus 
pallidus, and subthalamic nucleus. Tuft-shaped astrocytes were also seen. 
This patient appears to be a rare example of combination of MSA and PSP.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain ventricle dilatation (diagnosis); gait disorder (diagnosis); 
EMTREE MEDICAL INDEX TERMS
  aged; anamnesis; article; atelectasis (complication); bradycardia (complication); brain third ventricle; case report; clinical examination; human; male; nuclear magnetic resonance imaging; pleura effusion (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Radiology (14)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000282024
MEDLINE PMID
  10934728 (http://www.ncbi.nlm.nih.gov/pubmed/10934728)
PUI
  L30620256
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00068969&id=doi:&atitle=A+67-year-old+man+with+progressive+disturbance+of+gait&stitle=Brain+Nerve&title=Brain+and+Nerve&volume=52&issue=7&spage=643&epage=653&aulast=Sato&aufirst=K.-I.&auinit=K.-I.&aufull=Sato+K.-I.&coden=NOTOA&isbn=&pages=643-653&date=2000&auinit1=K&auinitm=-I
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 960
TITLE
  Patient preference for in-exsufflation for secretion management with spinal 
cord injury.
AUTHOR NAMES
  Garstang S.V.; Kirshblum S.C.; Wood K.E.
AUTHOR ADDRESSES
  (Garstang S.V.; Kirshblum S.C.; Wood K.E.) University of Medicine and 
Dentistry of New Jersey-New Jersey Medical School, Department of Physical 
Medicine and Rehabilitation, Newark, USA.
CORRESPONDENCE ADDRESS
  S.V. Garstang, University of Medicine and Dentistry of New Jersey-New Jersey 
Medical School, Department of Physical Medicine and Rehabilitation, Newark, 
USA.
FULL RECORD ENTRY DATE
  2000-12-11
SOURCE
  The journal of spinal cord medicine (2000) 23:2 (80-85). Date of 
Publication: 2000 Summer
VOLUME
  23
ISSUE
  2
FIRST PAGE
  80
LAST PAGE
  85
DATE OF PUBLICATION
  2000 Summer
ISSN
  1079-0268
ABSTRACT
  An important aspect of respiratory management in patients with acute spinal 
cord injury (SCI) is the elimination of secretions. Methods utilized for 
secretion management in patients with SCI includes endotracheal suctioning 
and mechanical in-exsufflation (MI-E). Surveyed here is a group of patients 
with SCI who have had experience with both endotracheal suctioning and MI-E 
via tracheostomy, to determine patient opinions and experiences regarding 
the 2 techniques. The survey was administered to 18 patients with traumatic 
SCI, with an average age of 34. 72% were ASIA A, 22% percent were ASIA B, 
and 6% were ASIA C, with neurological level of injury ranging from C-1-T-3. 
Results indicate that patients found MI-E significantly less irritating (p < 
0.001), less painful (p < 0.001), less tiring (p = 0.01), and less 
uncomfortable (p < 0.001) than endotracheal suctioning. In a direct 
comparison, 89% of patients preferred mechanical in-exsufflation to 
suctioning. In addition, 89% of patients found MI-E faster, 78% found MI-E 
more convenient, and 72% found MI-E more effective than suctioning. This 
study demonstrates that all measured aspects of patient experience are more 
positive for MI-E than for endotracheal suctioning.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; spinal cord injury (rehabilitation); suction; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; female; human; male; middle aged; psychological aspect; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  10914345 (http://www.ncbi.nlm.nih.gov/pubmed/10914345)
PUI
  L31348494
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10790268&id=doi:&atitle=Patient+preference+for+in-exsufflation+for+secretion+management+with+spinal+cord+injury.&stitle=J+Spinal+Cord+Med&title=The+journal+of+spinal+cord+medicine&volume=23&issue=2&spage=80&epage=85&aulast=Garstang&aufirst=S.V.&auinit=S.V.&aufull=Garstang+S.V.&coden=&isbn=&pages=80-85&date=2000&auinit1=S&auinitm=V
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 961
TITLE
  Bilateral vocal cord paralysis after anterior cervical discoidectomy and 
fusion in a case of whiplash cervical spine injury: A case report
AUTHOR NAMES
  Muzumdar D.P.; Deopujari C.E.; Bhojraj S.Y.
AUTHOR ADDRESSES
  (Muzumdar D.P.; Deopujari C.E.; Bhojraj S.Y.) Department of Neurosurgery, 
P.D. Hinduja Natl. Hosp. Med. R., Mumbai, India.
CORRESPONDENCE ADDRESS
  D.P. Muzumdar, Sahitya Sahawas, 4 Vagvaijayanti, Bandra (East) 400051, 
India.
FULL RECORD ENTRY DATE
  2000-09-15
SOURCE
  Surgical Neurology (2000) 53:6 (586-588). Date of Publication: 1 Jun 2000
VOLUME
  53
ISSUE
  6
FIRST PAGE
  586
LAST PAGE
  588
DATE OF PUBLICATION
  1 Jun 2000
ISSN
  0090-3019
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  BACKGROUND: Bilateral vocal cord paralysis is a risk of anterior cervical 
discoidectomy and fusion. We discuss the mechanism of vocal cord paralysis 
and the precautions necessary to avoid this catastrophic complication. A 
rare case of bilateral vocal cord paralysis after anterior cervical 
discoidectomy and fusion (ACD/F) is reported. CASE DESCRIPTION: The patient, 
a 37-year-old male, was paraplegic, had bilateral intrinsic hand muscle 
weakness and sphincter involvement following a whiplash cervical spinal 
injury. A C5-C6 ACD/F for traumatic C5-C6 disc prolapse was performed. On 
the third postoperative day, he developed difficulty in coughing and a husky 
voice. Otolaryngological evaluation revealed bilateral vocal cord paralysis. 
He later required a tracheostomy that partially alleviated his major 
symptoms. CONCLUSION: In patients undergoing ACD/F, a mandatory preoperative 
evaluation of the vocal cords should be performed. An appropriate 
modification in surgical planning should be made if vocal cord palsy is 
diagnosed preoperatively to prevent bilateral vocal cord paralysis. Proper 
and judicious use of Cloward retractors is advocated. (C) 2000 by Elsevier 
Science Inc.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (surgery); vocal cord paralysis (complication); whiplash injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; anterior spine fusion; article; case report; discectomy; human; male; postoperative complication; treatment outcome; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000285871
MEDLINE PMID
  10940428 (http://www.ncbi.nlm.nih.gov/pubmed/10940428)
PUI
  L30625168
DOI
  10.1016/S0090-3019(00)00245-7
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0090-3019(00)00245-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00903019&id=doi:10.1016%2FS0090-3019%2800%2900245-7&atitle=Bilateral+vocal+cord+paralysis+after+anterior+cervical+discoidectomy+and+fusion+in+a+case+of+whiplash+cervical+spine+injury%3A+A+case+report&stitle=Surg.+Neurol.&title=Surgical+Neurology&volume=53&issue=6&spage=586&epage=588&aulast=Muzumdar&aufirst=D.P.&auinit=D.P.&aufull=Muzumdar+D.P.&coden=SGNRA&isbn=&pages=586-588&date=2000&auinit1=D&auinitm=P
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 962
TITLE
  Upper airways obstruction
AUTHOR NAMES
  Lloyd E.L.
AUTHOR ADDRESSES
  (Lloyd E.L.) BASM, 72 Belgrave Road, Edinburgh EH12 6NQ, United Kingdom.
CORRESPONDENCE ADDRESS
  E.L. Lloyd, BASM, 72 Belgrave Road, Edinburgh EH12 6NQ, United Kingdom.
FULL RECORD ENTRY DATE
  2000-05-28
SOURCE
  British Journal of Sports Medicine (2000) 34:1 (69-70). Date of Publication: 
2000
VOLUME
  34
ISSUE
  1
FIRST PAGE
  69
LAST PAGE
  70
DATE OF PUBLICATION
  2000
ISSN
  0306-3674
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  resuscitation; upper respiratory tract obstruction (etiology); 
EMTREE MEDICAL INDEX TERMS
  article; blood; cervical spinal cord injury (complication); chin; edema; endotracheal intubation; face injury; head tilting; human; injury; jaw; laryngeal mask; nasopharynx; oropharynx; procedures; skull base fracture; tongue; tracheotomy; vomiting; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2000173852
MEDLINE PMID
  10690456 (http://www.ncbi.nlm.nih.gov/pubmed/10690456)
PUI
  L30265415
DOI
  10.1136/bjsm.34.1.69
FULL TEXT LINK
  http://dx.doi.org/10.1136/bjsm.34.1.69
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03063674&id=doi:10.1136%2Fbjsm.34.1.69&atitle=Upper+airways+obstruction&stitle=Br.+J.+Sports+Med.&title=British+Journal+of+Sports+Medicine&volume=34&issue=1&spage=69&epage=70&aulast=Lloyd&aufirst=E.L.&auinit=E.L.&aufull=Lloyd+E.L.&coden=BJSMD&isbn=&pages=69-70&date=2000&auinit1=E&auinitm=L
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 963
TITLE
  Spinal muscular atrophy type 1: A noninvasive respiratory management 
approach
AUTHOR NAMES
  Bach J.R.; Niranjan V.; Weaver B.
AUTHOR ADDRESSES
  (Bach J.R., bachjr@umdnj.edu) Dept. of Phys. Med. and Rehab., University 
Hospital, Newark, NJ, United States.
(Niranjan V.) Department of Pediatrics, University Hospital, Newark, NJ, 
United States.
(Weaver B.) Univ. of Med./D. of N. J.-N. J., University Hospital, Newark, 
NJ, United States.
(Bach J.R., bachjr@umdnj.edu) Dept. of Phys. Med. and Rehab., University 
Hospital B-403, 150 Bergen Street, Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Dept. of Physical Med. and Rehab., University Hospital B-403, 150 
Bergen Street, Newark, NJ 07103, United States. Email: bachjr@umdnj.edu
FULL RECORD ENTRY DATE
  2000-05-12
SOURCE
  Chest (2000) 117:4 (1100-1105). Date of Publication: 2000
VOLUME
  117
ISSUE
  4
FIRST PAGE
  1100
LAST PAGE
  1105
DATE OF PUBLICATION
  2000
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Study objective: To determine whether spinal muscular atrophy (SMA) type 1 
can be managed without tracheostomy and to compare extubation outcomes using 
a respiratory muscle aid protocol vs conventional management. Design: A 
retrospective cohort study. Methods: Eleven SMA type 1 children were studied 
during episodes of respiratory failure. Nine children required multiple 
intubations. Along with standard treatments, these children received 
manually and mechanically assisted coughing to reverse airway 
mucus-associated decreases in oxyhemoglobin saturation. Extubation was not 
attempted until, most importantly, there was no oxygen requirement to 
maintain oxyhemoglobin saturation greater than 94%. After extubation, all 
patients received nasal ventilation with positive end-expiratory pressure. 
Successful extubation was defined by no need to reintubate during the 
current hospitalization. I Results: Two children have survived for 37 and 66 
months and have never been intubated despite requiring 24-h nasal 
ventilation since 5 and 7 months of age, respectively. One other child 
underwent tracheostomy for persistent left lung collapse and inadequate home 
care, another for need for frequent readmission and intubation, and one 
child was lost to follow-up 3 months after successful extubation. The other 
six children have been managed at home for 15 to 59 (mean 30.4) months using 
nocturnal nasal ventilation after an episode of respiratory failure. The 
nine children were successfully extubated by our protocol 23 of 28 times. 
The same children managed conventionally were successfully extubated 2 of 20 
times when not using this protocol (p < 0.001 by the two-tailed Fisher's 
Exact t Test). Conclusion: Although intercurrent chest colds may necessitate 
periods of hospitalization and intubation, tracheostomy can be avoided 
throughout early childhood for some children with SMA type 1.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory failure (complication); spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  article; child; child hospitalization; clinical article; endotracheal intubation; extubation; female; follow up; human; male; priority journal; tracheotomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Human Genetics (22)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000151950
MEDLINE PMID
  10767247 (http://www.ncbi.nlm.nih.gov/pubmed/10767247)
PUI
  L30228371
DOI
  10.1378/chest.117.4.1100
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.117.4.1100
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.117.4.1100&atitle=Spinal+muscular+atrophy+type+1%3A+A+noninvasive+respiratory+management+approach&stitle=Chest&title=Chest&volume=117&issue=4&spage=1100&epage=1105&aulast=Bach&aufirst=John+R.&auinit=J.R.&aufull=Bach+J.R.&coden=CHETB&isbn=&pages=1100-1105&date=2000&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 964
TITLE
  Education, special needs, and medical exclusions: A good 'IDEA'?
AUTHOR NAMES
  Weiss K.J.
AUTHOR ADDRESSES
  (Weiss K.J.) Delaware Valley Res. Assoc., Inc., .
(Weiss K.J.) 922 Fayette St., Conshohocken, PA 19428, United States.
CORRESPONDENCE ADDRESS
  K.J. Weiss, 922 Fayette St., Conshohocken, PA 19428, United States.
FULL RECORD ENTRY DATE
  2000-04-24
SOURCE
  Journal of the American Academy of Psychiatry and the Law (2000) 28:1 
(102-106). Date of Publication: 2000
VOLUME
  28
ISSUE
  1
FIRST PAGE
  102
LAST PAGE
  106
DATE OF PUBLICATION
  2000
ISSN
  1093-6793
BOOK PUBLISHER
  American Academy of Psychiatry and the Law, 1 Regency Drive, P.O. Box 30, 
Bloomfield, United States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  disability; handicapped child; 
EMTREE MEDICAL INDEX TERMS
  adoption; child; child welfare; hospitalization; human; law; quadriplegia; review; spinal cord injury; tracheostomy; United States; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Psychiatry (32)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2000131544
MEDLINE PMID
  10774849 (http://www.ncbi.nlm.nih.gov/pubmed/10774849)
PUI
  L30196445
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10936793&id=doi:&atitle=Education%2C+special+needs%2C+and+medical+exclusions%3A+A+good+%27IDEA%27%3F&stitle=J.+Am.+Acad.+Psychiatry+Law&title=Journal+of+the+American+Academy+of+Psychiatry+and+the+Law&volume=28&issue=1&spage=102&epage=106&aulast=Weiss&aufirst=Kenneth+J.&auinit=K.J.&aufull=Weiss+K.J.&coden=JAPLF&isbn=&pages=102-106&date=2000&auinit1=K&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 965
TITLE
  Endothelin-1 in the brain of patients with galactosialidosis: Its abnormal 
increase and distribution pattern
AUTHOR NAMES
  Itoh K.; Oyanagi K.; Takahashi H.; Sato T.; Hashizume Y.; Shimmoto M.; Sakuraba H.
AUTHOR ADDRESSES
  (Itoh K.; Shimmoto M.; Sakuraba H.) Department of Clinical Genetics, Tokyo 
Metropol. Inst. of Med. Sci., Tokyo Metropol. Org. Tor Med. Res., Tokyo, 
Japan.
(Oyanagi K.) Department of Neuropathology, Tokyo Metropol. Inst. for 
Neurosci., Tokyo, Japan.
(Takahashi H.) Department of Pathology, Brain Research Institute, Niigata 
University, Niigata, Japan.
(Sato T.) Kohnodai Hospital, Natl. Ctr. of Neurol. and Psychiatry, Chiba, 
Japan.
(Hashizume Y.) Inst. for Medical Science of Aging, Aichi Medical University, 
Aichi, Japan.
(Itoh K.) Institute for Medicinal Resources, Faculty of Pharmaceutical 
Sciences, University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan.
CORRESPONDENCE ADDRESS
  K. Itoh, Institute for Medicinal Resources, Faculty of Pharmaceutical 
Sciences, University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan.
FULL RECORD ENTRY DATE
  2000-01-21
SOURCE
  Annals of Neurology (2000) 47:1 (122-126). Date of Publication: 2000
VOLUME
  47
ISSUE
  1
FIRST PAGE
  122
LAST PAGE
  126
DATE OF PUBLICATION
  2000
ISSN
  0364-5134
BOOK PUBLISHER
  John Wiley and Sons Inc., P.O.Box 18667, Newark, United States.
ABSTRACT
  Endothelin-1 is a peptidic substrate in vitro of lysosomal protective 
protein/cathepsin A (PPCA) with serine carboxypeptidase activity. 
Endothelin- 1-specific immunoreactivity has been demonstrated to be markedly 
increased and distributed abnormally in the neurons and glial cells within 
autopsied brain regions, including the cerebellum, hippocampal formation, 
and spinal cord, of patients affected with galactosialidosis, a human PPCA 
deficiency. The genetic defect of the endothelin-1 degrading activity of 
PPCA is suggested to cause some of the neurological abnormalities of this 
disease.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  endothelin 1 (endogenous compound); 
EMTREE DRUG INDEX TERMS
  cathepsin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  galactosialidosis (diagnosis, etiology); mental retardation malformation syndrome (congenital disorder, diagnosis); seizure (diagnosis, etiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; ataxia (diagnosis); case report; cause of death; cerebellar ataxia (diagnosis); child; dentate nucleus; face dysmorphia (diagnosis); hemangiokeratoma (diagnosis); human; hyperreflexia (diagnosis); immunohistochemistry; male; muscle atrophy (diagnosis); myoclonus (diagnosis); priority journal; tracheostomy; visual disorder (diagnosis); 
CAS REGISTRY NUMBERS
  cathepsin (9004-08-4)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Clinical and Experimental Biochemistry (29)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000023237
MEDLINE PMID
  10632112 (http://www.ncbi.nlm.nih.gov/pubmed/10632112)
PUI
  L30033661
DOI
  10.1002/1531-8249(200001)47:1<122::AID-ANA21>3.0.CO;2-9
FULL TEXT LINK
  http://dx.doi.org/10.1002/1531-8249(200001)47:1<122::AID-ANA21>3.0.CO;2-9
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03645134&id=doi:10.1002%2F1531-8249%28200001%2947%3A1%3C122%3A%3AAID-ANA21%3E3.0.CO%3B2-9&atitle=Endothelin-1+in+the+brain+of+patients+with+galactosialidosis%3A+Its+abnormal+increase+and+distribution+pattern&stitle=Ann.+Neurol.&title=Annals+of+Neurology&volume=47&issue=1&spage=122&epage=126&aulast=Itoh&aufirst=Kohji&auinit=K.&aufull=Itoh+K.&coden=ANNED&isbn=&pages=122-126&date=2000&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 966
TITLE
  Percutaneous tracheostomy in the severely injured patient: Transition from 
the operating room to the intensive care unit
AUTHOR NAMES
  Mayberry J.C.; Goldman R.K.; Rehm C.G.
AUTHOR ADDRESSES
  (Mayberry J.C.; Goldman R.K.; Rehm C.G.) Department of Surgery-L223A, 3181 
SW Sam Jackson Park Road, Portland, OR 97201-3098, United States.
CORRESPONDENCE ADDRESS
  J.C. Mayberry, Department of Surgery-L223A, 3181 SW Sam Jackson Park Road, 
Portland, OR 97201-3098, United States. Email: mayberrj@ohsu.edu
FULL RECORD ENTRY DATE
  2000-01-17
SOURCE
  Asian Journal of Surgery (1999) 22:4 (392-397). Date of Publication: 1999
VOLUME
  22
ISSUE
  4
FIRST PAGE
  392
LAST PAGE
  397
DATE OF PUBLICATION
  1999
ISSN
  1015-9584
ABSTRACT
  This paper describes the authors' experience with percutaneous tracheostomy 
(PT) in injured patients by transitioning the procedure from the OR to the 
ICU. One hundred and seven consecutive trauma patients receiving PT at a 
university-based Level I trauma center from 1 August, 1995 to 31 March, 1999 
were retrospectively and prospectively analyzed. The overall success and 
complication rates were 99% (106/107) and 11% (12/107), respectively, with 
zero procedure-related deaths. Twenty-seven PTs were performed in the OR 
before attempting PT in the ICU. The ICU PT complication rate was 9% (6/66) 
versus 15% (6/35) for OR PTs (p = NS). Ciaglia PT kits were used in 55 
patients and Per-fit® PT kits in 52 patients with identical complication 
rates (11%). Seventy-one patients had no cervical-spine injuries, 30 
patients had not been cleaved of c-spine injury, and six patients were 
stabilized prior to PT. C-spine clearance, neck extension, spine 
stabilization, and c-spine injury made no difference in success or 
complication rates (p = NS). No patient had spinal cord injury resulting 
from PT. It is concluded that PT can be safely performed on trauma patients 
at the ICU bedside. PT can be performed prior to c-spine clearance and in 
patients with known spinal injuries as long as spinal cord precautions are 
maintained. PT is the authors' procedure of choice for severely injured 
patients requiring tracheostomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; operating room; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; devices; human; injury (etiology, surgery); major clinical study; postoperative complication (complication, epidemiology); spinal cord injury; spine stabilization; 
DEVICE TRADE NAMES
  Ciaglia PT kit  , United StatesCook

  Per-fit  , United StatesSims

  Shiley tracheostomy tube  , United StatesMallinckrodt

DEVICE MANUFACTURERS
   (United States)Cook
   (United States)Mallinckrodt
   (United States)Sims
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Anesthesiology (24)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2000017693
PUI
  L30025982
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10159584&id=doi:&atitle=Percutaneous+tracheostomy+in+the+severely+injured+patient%3A+Transition+from+the+operating+room+to+the+intensive+care+unit&stitle=Asian+J.+Surg.&title=Asian+Journal+of+Surgery&volume=22&issue=4&spage=392&epage=397&aulast=Mayberry&aufirst=J.C.&auinit=J.C.&aufull=Mayberry+J.C.&coden=AJSUE&isbn=&pages=392-397&date=1999&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 967
TITLE
  Ultrasonographically guided percutaneous dilatational tracheostomy after 
anterior cervical spine fixation
AUTHOR NAMES
  Šustić A.; Župan Ž.; Eškinja N.; Dirlić A.; Bajek G.
AUTHOR ADDRESSES
  (Šustić A.) Dept. of Anesthesiology and ICU, University Hospital Rijeka, T. 
Strižića 3, Rijeka 51000, Croatia.
(Župan Ž.; Eškinja N.; Dirlić A.; Bajek G.)
CORRESPONDENCE ADDRESS
  A. Sustc, Dept. of Anesthesiology and ICU, University Hospital Rijeka, T. 
Strizica 3, Rijeka 51000, Croatia.
FULL RECORD ENTRY DATE
  1999-11-23
SOURCE
  Acta Anaesthesiologica Scandinavica (1999) 43:10 (1078-1080). Date of 
Publication: 1999
VOLUME
  43
ISSUE
  10
FIRST PAGE
  1078
LAST PAGE
  1080
DATE OF PUBLICATION
  1999
ISSN
  0001-5172
BOOK PUBLISHER
  Blackwell Munksgaard, 1 Rosenorns Alle, P.O. Box 227, Copenhagen V, Denmark.
ABSTRACT
  Patients with anterior cervical spine fixation (ACSF) after acute spinal 
cord injury often require tracheostomy for prolonged ventilatory support and 
upper respiratory tract clearance. The authors report two patients with ACSF 
who underwent a successful ultrasonographically guided percutaneous 
tracheostomy with dilatation forceps technique. Possible advantages of the 
ultrasonographically guided method with dilatation forceps in patients with 
ACSF are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; anterior spine fusion; article; artificial ventilation; case report; human; lung clearance; male; priority journal; spine stabilization; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1999394033
MEDLINE PMID
  10593475 (http://www.ncbi.nlm.nih.gov/pubmed/10593475)
PUI
  L29529825
DOI
  10.1034/j.1399-6576.1999.431019.x
FULL TEXT LINK
  http://dx.doi.org/10.1034/j.1399-6576.1999.431019.x
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00015172&id=doi:10.1034%2Fj.1399-6576.1999.431019.x&atitle=Ultrasonographically+guided+percutaneous+dilatational+tracheostomy+after+anterior+cervical+spine+fixation&stitle=Acta+Anaesthesiol.+Scand.&title=Acta+Anaesthesiologica+Scandinavica&volume=43&issue=10&spage=1078&epage=1080&aulast=%C5%A0usti%C4%87&aufirst=Alan&auinit=A.&aufull=%C5%A0usti%C4%87+A.&coden=AANEA&isbn=&pages=1078-1080&date=1999&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 968
TITLE
  False positive perfusion lung scintiscans in tetraplegic patients: A case 
series
AUTHOR NAMES
  O'Ferrall D.J.M.; Cohn J.R.; Rider-Foster D.
AUTHOR ADDRESSES
  (O'Ferrall D.J.M.) Dept. of Phys. Med. and Rehab., Thomas Jefferson 
University Hospital, .
(Cohn J.R.) Department of Medicine, Thomas Jefferson University Hospital, .
(Rider-Foster D.) Magee Rehabilitation Hospital, Philadelphia, PA, United 
States.
(O'Ferrall D.J.M.) Dept. of Phys. Med. and Rehab., John Hopkins University, 
School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, United States.
CORRESPONDENCE ADDRESS
  D.J.M. O'Ferrall, Physical Medicine and Rehabilitation, John Hopkins 
University, School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, 
United States.
FULL RECORD ENTRY DATE
  1999-10-20
SOURCE
  Archives of Physical Medicine and Rehabilitation (1999) 80:10 (1343-1345). 
Date of Publication: October 1999
VOLUME
  80
ISSUE
  10
FIRST PAGE
  1343
LAST PAGE
  1345
DATE OF PUBLICATION
  October 1999
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  An accurate diagnosis of pulmonary embolism is essential to prevent 
excessive morbidity and mortality from either inappropriate therapy or 
failure to institute anticoagulation. The diagnosis of pulmonary embolism in 
tetraplegic spinal cord injury patients is complicated by frequent inability 
to perform the ventilation portion of the ventilation-perfusion scintiscan 
(V/Q scan) and by controversy regarding classification of defects on 
perfusion-only scans, as well as by coexisting pulmonary disease, systemic 
illness, related injuries, and the tendency for tetraplegic patients to have 
unexplained fever. This report describes three tetraplegic ventilator- 
dependent patients with hypoxic respiratory failure and normal chest 
radiographs who had large defects on perfusion-only lung scans. Ventilation 
scintiscans were not performed because the patients were 
ventilator-dependent with tracheostomies. Pulmonary angiography findings 
were normal in all patients, and all three responded to aggressive pulmonary 
toilet. Even large defects on perfusion-only scans despite normal chest 
radiographs should not be used to establish a diagnosis of pulmonary 
embolism in tetraplegic patients, and further diagnostic imaging is 
warranted.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lung embolism (diagnosis); lung scintiscanning; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; controlled study; diagnostic accuracy; diagnostic error; female; human; image analysis; lung ventilation perfusion ratio; male; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Nuclear Medicine (23)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1999352689
MEDLINE PMID
  10527099 (http://www.ncbi.nlm.nih.gov/pubmed/10527099)
PUI
  L29474629
DOI
  10.1016/S0003-9993(99)90041-2
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-9993(99)90041-2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2FS0003-9993%2899%2990041-2&atitle=False+positive+perfusion+lung+scintiscans+in+tetraplegic+patients%3A+A+case+series&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=80&issue=10&spage=1343&epage=1345&aulast=O%27Ferrall&aufirst=Dermot+J.+More&auinit=D.J.M.&aufull=O%27Ferrall+D.J.M.&coden=APMHA&isbn=&pages=1343-1345&date=1999&auinit1=D&auinitm=J.M.
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 969
TITLE
  Predictors of dysphagia after spinal cord injury
AUTHOR NAMES
  Kirshblum S.; Johnston M.V.; Brown J.; O'Connor K.C.; Jarosz P.
AUTHOR ADDRESSES
  (Kirshblum S.; Brown J.) Spinal Cord Injury Services, Speech-Language 
Pathology, Kessler Inst. Rehab., Outcomes Res., West Orange, NJ, United 
States.
(Jarosz P.) Outpatient Services, Speech-Language Pathology, Kessler Inst. 
Rehab., Outcomes Res., West Orange, NJ, United States.
(Johnston M.V.) Outcomes Research, Kessler Med. Rehab. Res. Educ. Corp., 
West Orange, NJ, United States.
(Kirshblum S.; Johnston M.V.; O'Connor K.C.) Dept. of Phys. Med. and Rehab., 
Univ. Med. and Dent. of New Jersey, New Jersey Medical School, Newark, NJ, 
United States.
(Kirshblum S.) Kessler Institute for Rehabilitation, 1199 Pleasant Valley 
Way, West Orange, NJ 07052, United States.
CORRESPONDENCE ADDRESS
  S. Kirshblum, Kessler Institute for Rehabilitation, 1199 Pleasant Valley 
Way, West Orange, NJ 07052, United States.
FULL RECORD ENTRY DATE
  1999-09-28
SOURCE
  Archives of Physical Medicine and Rehabilitation (1999) 80:9 (1101-1105). 
Date of Publication: September 1999
VOLUME
  80
ISSUE
  9
FIRST PAGE
  1101
LAST PAGE
  1105
DATE OF PUBLICATION
  September 1999
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Objective: To quantify the incidence of swallowing deficits (dysphagia) and 
to identify factors that predict risk for dysphagia in the rehabilitation 
setting following acute traumatic spinal cord injury. Design: Retrospective 
case-control study. Setting: Freestanding rehabilitation hospital. Patients: 
Data were collected on 187 patients with acute traumatic spinal cord injury 
admitted for rehabilitation over a 4-year period who underwent a swallowing 
screen, in which 42 underwent a videofluoroscopic swallowing study (VFSS). 
Main Outcome Measures: VFSS was performed on patients with suspected 
swallowing problems. Possible antecedents of dysphagia were recorded from 
the medical record including previous history of spine surgery, surgical 
approach and technique, tracheostomy and ventilator status, neurologic level 
of injury, ASIA Impairment Classification, orthosis, etiology of injury, 
age, and gender. Results: On admission to rehabilitation 22.5% (n = 42) of 
spinal cord injury patients had symptoms suggesting dysphagia. In 73.8% (n = 
31) of these cases, testing confirmed dysphagia (aspiration or requiring a 
modified diet), while VFSS ruled out dysphagia in 26 2% (n = 11) cases. 
Logistic regression and other analyses revealed three significant predictors 
of risk for dysphagia: age (p < 028), tracheostomy and mechanical 
ventilation (p < .001), and spinal surgery via an anterior cervical approach 
(p < 016). Other variables analyzed had no relation or at best a alight 
relation to dysphagia. Tracheostomy at admission was the strongest predictor 
of dysphagia. The combination of tracheostomy at rehabilitation admission 
and anterior surgical approach had an extremely high rate of dysphagia 
(48%). Conclusion: Swallowing abnormalities are present in a significant 
percentage of patients presenting to rehabilitation with acute traumatic 
cervical spinal cord injury. Patients with a tracheostomy appear to have a 
substantially increased risk of development of dysphagia, although other 
factors are also relevant. Risk of dysphagia should be evaluated to decrease 
the potential for morbidity related to swallowing abnormalities.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  dysphagia (complication, diagnosis, epidemiology); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; artificial ventilation; female; fluoroscopy; high risk patient; hospital admission; human; incidence; major clinical study; male; prediction; rehabilitation center; spine surgery; surgical approach; tracheostomy; videorecording; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1999326080
MEDLINE PMID
  10489016 (http://www.ncbi.nlm.nih.gov/pubmed/10489016)
PUI
  L29439327
DOI
  10.1016/S0003-9993(99)90068-0
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-9993(99)90068-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2FS0003-9993%2899%2990068-0&atitle=Predictors+of+dysphagia+after+spinal+cord+injury&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=80&issue=9&spage=1101&epage=1105&aulast=Kirshblum&aufirst=Steven&auinit=S.&aufull=Kirshblum+S.&coden=APMHA&isbn=&pages=1101-1105&date=1999&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 970
TITLE
  Continuous epidural anesthesia with a double catheter for sedation for 
surgery of the vertebral dorsolumbar column
ORIGINAL (NON-ENGLISH) TITLE
  Anestesia epidurale continua mediante doppio catetere più sedazione per la 
chirurgia della colonna vertebrale dorso-lombare.
AUTHOR NAMES
  Meggiorin G.; Onali A.; Manduco G.; Coraddu M.
AUTHOR ADDRESSES
  (Meggiorin G.; Onali A.; Manduco G.; Coraddu M.) Azienda Ospedaliera G. 
Brotzu, Brotzu SMH Ospedale di Rilievo Nazionale e di Alla Specializzazione, 
Cagliari.
CORRESPONDENCE ADDRESS
  G. Meggiorin, Azienda Ospedaliera G. Brotzu, Brotzu SMH Ospedale di Rilievo 
Nazionale e di Alla Specializzazione, Cagliari.
FULL RECORD ENTRY DATE
  1999-11-17
SOURCE
  Minerva anestesiologica (1999) 65:9 (653-658). Date of Publication: Sep 1999
VOLUME
  65
ISSUE
  9
FIRST PAGE
  653
LAST PAGE
  658
DATE OF PUBLICATION
  Sep 1999
ISSN
  0375-9393
ABSTRACT
  The case of presented of an obese 42 year-old female patient, undergoing a 
second spinal cord decompression for a large dorsolumbar fibrous-scar mass, 
having a small-bore Montgomery tracheal stent (T-tube) on site. Stent 
replacement with a tracheotomy tube was impossible because of strong 
accretions hindering stent removal, as well as insertion of a suitable 
tracheal tube through the external stent branch, because of its very small 
lumen. So, general anaesthesia was not administered and surgery was 
performed under continuous epidural block, with light sedation, using two 
catheters introduced up and down the compression. Surgical and anaesthetic 
outcomes were optimal and confirm the effectiveness and safety of epidural 
anaesthesia for dorsolumbar spinal surgery, even in the obese patient. 
Moreover, with the continuous double-catheter technique it was possible to 
achieve a good and homogeneous spread of the analgesic solution, with low 
volume, despite the hard compression and deformation of the epidural space 
due to the fibrous-scar mass.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidural anesthesia; lumbar vertebra; spinal cord compression (complication, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; catheterization; decompression surgery; female; human; methodology; obesity (complication); 
LANGUAGE OF ARTICLE
  Italian
MEDLINE PMID
  10522137 (http://www.ncbi.nlm.nih.gov/pubmed/10522137)
PUI
  L129473153
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03759393&id=doi:&atitle=Continuous+epidural+anesthesia+with+a+double+catheter+for+sedation+for+surgery+of+the+vertebral+dorsolumbar+column&stitle=Minerva+Anestesiol&title=Minerva+anestesiologica&volume=65&issue=9&spage=653&epage=658&aulast=Meggiorin&aufirst=G.&auinit=G.&aufull=Meggiorin+G.&coden=&isbn=&pages=653-658&date=1999&auinit1=G&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 971
TITLE
  Tetraplegia after central venous line via Vena jugularis interna with a 
following cervical abscess
ORIGINAL (NON-ENGLISH) TITLE
  Tetraplegie nach Vena-jugularis-interna-punktion mit nachfolgendem 
zervikalen abszess
AUTHOR NAMES
  Fritz K.-W.; Turner E.
AUTHOR ADDRESSES
  (Fritz K.-W.; Turner E.) Sudetenweg 6, D-26441 Jever, Germany.
CORRESPONDENCE ADDRESS
  K.-W. Fritz, Sudetenweg 6, D-26441 Jever, Germany.
FULL RECORD ENTRY DATE
  1999-08-10
SOURCE
  Intensiv- und Notfallbehandlung (1999) 24:2 (93-97). Date of Publication: 
1999
VOLUME
  24
ISSUE
  2
FIRST PAGE
  93
LAST PAGE
  97
DATE OF PUBLICATION
  1999
ISSN
  0947-5362
ABSTRACT
  We report on a case of upper tetraplegia caused by an abscess following the 
insertion of a central venous line (Vena jugularis interna). Bacteria may be 
applied by non-sterile punction. The cervical myelon was compressed and 2 
vertebras (C4, C5), were destructed. The abscess was evacuated. The patient 
needed 3 weeks ventilatory support (controlled/assisted). A tracheotomy was 
performed for better suction of the bronchial system. The initial 
tetraplegia disappeared slowly. Physiotherapy supported the disorder of the 
muscles. Seven months after the event the patient is able to walk small 
distances. As we didn't find a report about such a severe case with 
following particular Restitutio ad integrum it was our desire to present it.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  central venous catheterization; quadriplegia (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; human; internal jugular vein; pelvis abscess (complication); physiotherapy; spinal cord compression (complication); tracheotomy; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  1999268512
PUI
  L29359535
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09475362&id=doi:&atitle=Tetraplegia+after+central+venous+line+via+Vena+jugularis+interna+with+a+following+cervical+abscess&stitle=Intensiv-+Notfallbehandl.&title=Intensiv-+und+Notfallbehandlung&volume=24&issue=2&spage=93&epage=97&aulast=Fritz&aufirst=K.-W.&auinit=K.-W.&aufull=Fritz+K.-W.&coden=INNTE&isbn=&pages=93-97&date=1999&auinit1=K&auinitm=-W
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 972
TITLE
  External laryngeal trauma analysis of 392 patients
AUTHOR NAMES
  Jewett B.S.; Shockley W.W.; Rutledge R.
AUTHOR ADDRESSES
  (Jewett B.S.; Shockley W.W.) Div. Otolaryngol. - Hd. Neck Surg., Univ. of N. 
Carolina Medical Center, Chapel Hill, NC, United States.
(Rutledge R.) Department of Surgery, Univ. of N. Carolina Medical Center, 
Chapel Hill, NC, United States.
(Jewett B.S.) Div. Otolaryngol. - Hd. Neck Surg., Univ. of N. Carolina Sch. 
of Med., CB 7070, 610 Burnette Womack, Chapel Hill, NC 27599-7070, United 
States.
CORRESPONDENCE ADDRESS
  B.S. Jewett, Otolaryngology-Hd./Neck Surg. Div., Univ. of North Carolina 
Sch. of Med., 610 Burnette Womack, Chapel Hill, NC 27599-7070, United 
States.
FULL RECORD ENTRY DATE
  1999-08-17
SOURCE
  Archives of Otolaryngology - Head and Neck Surgery (1999) 125:8 (877-880). 
Date of Publication: August 1999
VOLUME
  125
ISSUE
  8
FIRST PAGE
  877
LAST PAGE
  880
DATE OF PUBLICATION
  August 1999
ISSN
  0886-4470
BOOK PUBLISHER
  American Medical Association, 515 North State Street, Chicago, United 
States.
ABSTRACT
  Background: External laryngeal trauma (ELT) is a rare but clinically 
important injury. Objective: To perform the first population-based, time 
series analysis of the epidemiology, management, and outcomes of ELT using 
an 11-state, inpatient sample database containing more than 54 million 
patients. Patients: Three hundred ninety-two patients with a primary or 
secondary diagnosis of ELT were identified. Over a 5-year period, the 
incidence of ELT in this series was 1/137 000. The mean (±SD) age was 37 
(±7) years, and the overall mortality rate was 2.04%. Two hundred 
forty-eight patients required surgical intervention. Results: The average 
length of stay for 67 patients not requiring surgical intervention for any 
injury was 3 (±2) days, with no mortality. One hundred eighty patients 
underwent endoscopy, with 14 requiting tracheotomy alone and 57 requiring 
tracheotomy plus laryngeal repair. The average length of stay and the 
morality rate were higher in these latter groups. Overall, 139 patients 
underwent tracheotomy, with a mortality rate of 5%, while 96 patients 
underwent laryngeal repair, with a mortality rate of 1%. Surgical treatment 
was performed in 140 patients with ELT within 24 hours after presentation, 
while another 60 received treatment within 48 hours. Associated injuries 
included skull base or intracranial injury (13%), open neck injury (9%), 
cervical spine injury (8%), and esophageal or pharyngeal injury (3%). 
Conclusion: External laryngeal trauma is a rare injury, with most patients 
requiring surgical intervention.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  larynx injury (diagnosis, epidemiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  adult; article; data base; female; human; larynx surgery; length of stay; major clinical study; male; mortality; prevalence; tracheotomy; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1999277831
MEDLINE PMID
  10448735 (http://www.ncbi.nlm.nih.gov/pubmed/10448735)
PUI
  L29372808
DOI
  10.1001/archotol.125.8.877
FULL TEXT LINK
  http://dx.doi.org/10.1001/archotol.125.8.877
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08864470&id=doi:10.1001%2Farchotol.125.8.877&atitle=External+laryngeal+trauma+analysis+of+392+patients&stitle=Arch.+Otolaryngol.+Head+Neck+Surg.&title=Archives+of+Otolaryngology+-+Head+and+Neck+Surgery&volume=125&issue=8&spage=877&epage=880&aulast=Jewett&aufirst=Brian+S.&auinit=B.S.&aufull=Jewett+B.S.&coden=AONSE&isbn=&pages=877-880&date=1999&auinit1=B&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 973
TITLE
  Complete upper airway obstruction during awake fibreoptic intubation in 
patients with unstable cervical spine fractures
AUTHOR NAMES
  McGuire G.; El-Beheiry H.
AUTHOR ADDRESSES
  (McGuire G.; El-Beheiry H., beheiry@playfair.utoronto.ca) Toronto Hospital, 
Western Division, University of Toronto, 399 Bathurst Street, Toronto, Ont. 
M5T 2S8, Canada.
CORRESPONDENCE ADDRESS
  H. El-Beheiry, Department of Anaesthesia, Toronto Hospital, University of 
Toronto, 399 Bathurst Street, Toronto, Ont. M5T 2S8, Canada. Email: 
beheiry@playfair.utoronto.ca
FULL RECORD ENTRY DATE
  1999-05-16
SOURCE
  Canadian Journal of Anaesthesia (1999) 46:2 (176-178). Date of Publication: 
1999
VOLUME
  46
ISSUE
  2
FIRST PAGE
  176
LAST PAGE
  178
DATE OF PUBLICATION
  1999
ISSN
  0832-610X
BOOK PUBLISHER
  Canadian Anaesthetists' Society, 1 Eglinton Avenue East, Suite 208, Toronto, 
Canada.
ABSTRACT
  Purpose: To describe the presentation and management of complete upper 
airway obstruction with life threatening arterial oxygen desaturation that 
occurred during attempted awake fibreoptic intubation in two patients 
presenting with unstable C-spine injury. Clinical Feature: Complete upper 
airway obstruction occurred during awake fibreoptic intubation of two men 
(ASA II; 68 and 55 yr old) presenting with unstable C-spine fractures. In 
both cases, bag and mask ventilation with CPAP failed to relieve the 
progressive hypoxemia. A surgical airway was established urgently to 
oxygenate the two patients who were suffering progressive life-threatening 
oxygen desaturation. One patient had trans-cricothyroid jet ventilation 
performed through a 16G intravenous cannula prior to an urgent tracheostomy. 
In the other patient, an emergency tracheostomy was inserted. Interestingly, 
both patients had been sedated in the Neurosurgical Intensive Care Unit with 
morphine and benzodiazepines before their scheduled surgeries. The most 
likely etiology for the complete upper airway obstruction was laryngospasm 
due to inadequate topicalization of the airway and additional sedation given 
in the operating room. Neither patients suffered any new neurological 
deficits following these events. They went on to have uneventful surgeries. 
Conclusion: This case report suggest that prior to awake fibreoptic 
intubation oxygenation, adequate topicalization with testing to verify the 
lack of pharyngeal and laryngeal responses and careful assessment of 
sedation levels in the operating room are prudent for a safe endoscopic 
intubation.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  benzodiazepine; morphine; 
EMTREE DRUG INDEX TERMS
  fentanyl; glycopyrronium; lidocaine; midazolam; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine fracture; upper respiratory tract obstruction; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; case report; emergency treatment; endotracheal intubation; human; hypoxemia (complication); intravenous drug administration; larynx spasm; male; oxygenation; positive end expiratory pressure; priority journal; sedation; tracheostomy; treatment outcome; 
CAS REGISTRY NUMBERS
  benzodiazepine (12794-10-4)
  fentanyl (437-38-7)
  glycopyrronium bromide (596-51-0)
  lidocaine (137-58-6, 24847-67-4, 56934-02-2, 73-78-9)
  midazolam (59467-70-8)
  morphine (52-26-6, 57-27-2)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  1999140916
MEDLINE PMID
  10083999 (http://www.ncbi.nlm.nih.gov/pubmed/10083999)
PUI
  L29185587
DOI
  10.1007/BF03012553
FULL TEXT LINK
  http://dx.doi.org/10.1007/BF03012553
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0832610X&id=doi:10.1007%2FBF03012553&atitle=Complete+upper+airway+obstruction+during+awake+fibreoptic+intubation+in+patients+with+unstable+cervical+spine+fractures&stitle=Can.+J.+Anaesth.&title=Canadian+Journal+of+Anaesthesia&volume=46&issue=2&spage=176&epage=178&aulast=McGuire&aufirst=Glenn&auinit=G.&aufull=McGuire+G.&coden=CJOAE&isbn=&pages=176-178&date=1999&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 974
TITLE
  An unusual case of stridor due to osteophytes of the cervical spine: 
(Forestier's disease)
AUTHOR NAMES
  Papakostas K.; Thakar A.; Nandapalan V.; O'Sullivan G.
AUTHOR ADDRESSES
  (Papakostas K.; Thakar A.; Nandapalan V.; O'Sullivan G.) Dept. Otolaryngol. 
- Hd. Neck Surg., Arrowe Park Hospital, Upton, Wirral, Merseyside, United 
Kingdom.
(Papakostas K.) ENT Department, University Hospital Aintree, Longmoor Lane, 
Liverpool L9 7AL, United Kingdom.
CORRESPONDENCE ADDRESS
  K. Papakostas, ENT Department, University Hospital Aintree, Longmoor Lane, 
Liverpool L9 7AL, United Kingdom.
FULL RECORD ENTRY DATE
  1999-02-03
SOURCE
  Journal of Laryngology and Otology (1999) 113:1 (65-67). Date of 
Publication: 1999
VOLUME
  113
ISSUE
  1
FIRST PAGE
  65
LAST PAGE
  67
DATE OF PUBLICATION
  1999
ISSN
  0022-2151
BOOK PUBLISHER
  Cambridge University Press, Shaftesbury Road, Cambridge, United Kingdom.
ABSTRACT
  Stridor is a noisy breathing caused by compromised airway in the larynx and 
trachea. The causes can either be due to intrinsic or extrinsic compression. 
Stridor resulting from extrinsic compression due to anterior cervical 
osteophytes is rare. We report an unusual case of acute stridor due to an 
osteophytic mass in the cervical vertebrae resulting in a mechanical upper 
airway obstruction. The underlying pathology was Forestier's disease or 
diffuse idiopathic skeletal hyperostosis (DISH). Stridor is a rare 
manifestation of DISH and it certainly represents the most life-threatening 
one. Only a few cases have been reported in the English literature and are 
mainly secondary to impaired function of the vocal folds, or postcricoid 
ulceration and oedema. We present such a case, in that stridor was the 
result of direct airway obstruction by the osteophytic mass and an emergency 
tracheostomy had to be performed to establish an airway.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ankylosing hyperostosis (etiology, surgery); spondylosis (etiology, surgery); stridor (etiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; airway constriction (etiology, surgery); article; breathing disorder (etiology, surgery); case report; cervical spine; compression; emergency surgery; human; larynx disorder (etiology, surgery); larynx edema (etiology); male; osteophyte (etiology, surgery); trachea disease (etiology, surgery); tracheostomy; ulcer (etiology); upper respiratory tract obstruction (etiology, surgery); vocal cord; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1999038857
MEDLINE PMID
  10341924 (http://www.ncbi.nlm.nih.gov/pubmed/10341924)
PUI
  L29050656
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00222151&id=doi:&atitle=An+unusual+case+of+stridor+due+to+osteophytes+of+the+cervical+spine%3A+%28Forestier%27s+disease%29&stitle=J.+Laryngol.+Otol.&title=Journal+of+Laryngology+and+Otology&volume=113&issue=1&spage=65&epage=67&aulast=Papakostas&aufirst=K.&auinit=K.&aufull=Papakostas+K.&coden=JLOTA&isbn=&pages=65-67&date=1999&auinit1=K&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 975
TITLE
  Current status of long term ventilation of children in the United Kingdom: 
Questionnaire survey
AUTHOR NAMES
  Jardine E.; O'Toole M.; Paton J.Y.; Wallis C.
AUTHOR ADDRESSES
  (Jardine E.; O'Toole M.; Wallis C., c.wallis@ich.ucl.ac.uk) Institute of 
Child Health, Gt. Ormond St. Hosp. for Children N., London WC1N 3JH, United 
Kingdom.
(Paton J.Y.) Department of Child Health, Yorkhill, Glasgow G3 8SJ, United 
Kingdom.
CORRESPONDENCE ADDRESS
  C. Wallis, Institute of Child Health, Gr. Ormond St. Hosp. Child. NHS Tr., 
London WC1N 3JH, United Kingdom. Email: c.wallis@ich.ucl.ac.uk
FULL RECORD ENTRY DATE
  1999-05-06
SOURCE
  British Medical Journal (1999) 318:7179 (295-299). Date of Publication: 30 
Jan 1999
VOLUME
  318
ISSUE
  7179
FIRST PAGE
  295
LAST PAGE
  299
DATE OF PUBLICATION
  30 Jan 1999
ISSN
  0959-8146
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
ABSTRACT
  Objectives. To identify the number and current location of children, aged 0 
to 16 years, requiring long term ventilation in the United Kingdom, and to 
establish their underlying diagnoses and ventilatory needs. Design. Postal 
questionnaires sent to consultant respiratory paediatricians and all lead 
clinicians of intensive care and special care baby units in the United 
Kingdom. Subjects. All children in the United Kingdom who, when medically 
stable, continued to need a mechanical aid for breathing. Results. 141 
children requiring long term ventilation were identified from the initial 
questionnaire. Detailed information was then obtained on 136 children from 
30 units. Thirty three children (24%) required continuous positive pressure 
ventilation by tracheostomy over 24 hours, and 103 received ventilation when 
asleep by a non-invasive mask (n = 62; 46%), tracheostomy (n = 32; 24%), or 
negative pressure ventilation (n = 9; 7%). Underlying conditions included 
neuromuscular disease (n = 62; 46%), congenital central hypoventilation 
syndrome (n = 18; 13%), spinal injury (n = 16; 12%), craniofacial syndromes 
(n = 9; 7%), bronchopulmonary dysplasia (n = 6; 4%), and others (n = 25; 
18%). 93 children were cared for at home. 43 children remained in hospital 
because of home circumstances, inadequate funding, or lack of provision of 
home carers. 96 children were of school age and 43 were attending mainstream 
school. Conclusions. A significant increase in the number of children 
requiring long term ventilation in the United Kingdom has occurred over the 
past decade, contributing factors include improvement technology, 
developments in paediatric non-invasive ventilatory support, and a change in 
attitude towards home care. Successful discharge home and return to school 
is occurring even for severely disabled patients. Funding and home carers 
are common obstacles to discharge.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; 
EMTREE MEDICAL INDEX TERMS
  article; child; craniofacial malformation (therapy); face mask; female; human; hypoventilation (congenital disorder, therapy); intensive care; lung disease (therapy); major clinical study; male; neuromuscular disease (therapy); positive end expiratory pressure; priority journal; questionnaire; spine injury (therapy); tracheostomy; United Kingdom; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1999148338
MEDLINE PMID
  9924054 (http://www.ncbi.nlm.nih.gov/pubmed/9924054)
PUI
  L29195137
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09598146&id=doi:&atitle=Current+status+of+long+term+ventilation+of+children+in+the+United+Kingdom%3A+Questionnaire+survey&stitle=Br.+Med.+J.&title=British+Medical+Journal&volume=318&issue=7179&spage=295&epage=299&aulast=Jardine&aufirst=E.&auinit=E.&aufull=Jardine+E.&coden=BMJOA&isbn=&pages=295-299&date=1999&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 976
TITLE
  Upper airway obstruction by retropharyngeal hematoma after cervical spine 
trauma: Report of a case treated with percutaneous dilational tracheostomy
AUTHOR NAMES
  Mazzon D.; Zanatta P.; Curtolo S.; Bernardi V.; Bosco E.
AUTHOR ADDRESSES
  (Mazzon D.; Zanatta P.; Bernardi V.; Bosco E.) Dept. Anaesthesia and 
Intensive Care, S.M. dei Battuti City Hospital, Treviso, Italy.
(Curtolo S.) Department of Neuroradiology, S.M. dei Battuti City Hospital, 
Treviso, Italy.
(Mazzon D.) Serv. Anesthesia and Intensive Care, S.M. dei Battuti Treviso 
City Hosp., 31100 Treviso, Italy.
CORRESPONDENCE ADDRESS
  D. Mazzon, Svc. of Anesthesia and Inten. Care, S.M. dei Battuti Treviso Cty. 
Hosp., 31100 Treviso, Italy.
FULL RECORD ENTRY DATE
  1998-11-28
SOURCE
  Journal of Neurosurgical Anesthesiology (1998) 10:4 (237-240). Date of 
Publication: October 1998
VOLUME
  10
ISSUE
  4
FIRST PAGE
  237
LAST PAGE
  240
DATE OF PUBLICATION
  October 1998
ISSN
  0898-4921
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  The authors report the case of a patient affected by a cervical spine trauma 
who developed upper airway obstruction as a result of a retropharyngeal 
hematoma. An endotracheal intubation with a small-diameter tube was 
performed, but ventilation and oxygenation were not adequate. An early 
Percutaneous Dilational Tracheostomy with the Ciaglia technique was then 
performed. The risk of upper airway obstruction by retropharyngeal hematoma 
after cervical spine trauma is discussed in this article, as are the 
feasibility and benefits of using Percutaneous Dilational Tracheostomy in 
emergency cases of upper airway obstruction.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; hematoma; upper respiratory tract obstruction; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; endotracheal intubation; human; lung ventilation; male; priority journal; risk assessment; tracheostomy; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1998347773
MEDLINE PMID
  9796608 (http://www.ncbi.nlm.nih.gov/pubmed/9796608)
PUI
  L28471618
DOI
  10.1097/00008506-199810000-00006
FULL TEXT LINK
  http://dx.doi.org/10.1097/00008506-199810000-00006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08984921&id=doi:10.1097%2F00008506-199810000-00006&atitle=Upper+airway+obstruction+by+retropharyngeal+hematoma+after+cervical+spine+trauma%3A+Report+of+a+case+treated+with+percutaneous+dilational+tracheostomy&stitle=J.+Neurosurg.+Anesthesiol.&title=Journal+of+Neurosurgical+Anesthesiology&volume=10&issue=4&spage=237&epage=240&aulast=Mazzon&aufirst=D.&auinit=D.&aufull=Mazzon+D.&coden=JNANE&isbn=&pages=237-240&date=1998&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 977
TITLE
  Respiratory problems after high cervical spine injury
ORIGINAL (NON-ENGLISH) TITLE
  Respiratorische probleme nach halsmarkverletzungen
AUTHOR NAMES
  Stocker R.; Bürgi U.
AUTHOR ADDRESSES
  (Stocker R.; Bürgi U.) Chirurgische Intensivmedizin, Departement Chirurgie, 
Universitätsspital, Zürich, Switzerland.
(Stocker R.) Leitender Arzt, Chirurgische Intensivmedizin, 
Universitätsspital, CH-8091 Zürich, Switzerland.
CORRESPONDENCE ADDRESS
  R. Stocker, Leitender Arzt, Chirurgische Intensivmedizin, 
Universitatsspital, CH-8091 Zurich, Switzerland.
FULL RECORD ENTRY DATE
  1998-10-18
SOURCE
  Schweizerische Medizinische Wochenschrift (1998) 128:39 (1462-1466). Date of 
Publication: 26 Sep 1998
VOLUME
  128
ISSUE
  39
FIRST PAGE
  1462
LAST PAGE
  1466
DATE OF PUBLICATION
  26 Sep 1998
ISSN
  0036-7672
BOOK PUBLISHER
  Schwabe A.G. Verlag, Steinentorstrasse 13, Basel, Switzerland.
ABSTRACT
  Respiratory failure plays a major role in morbidity and mortality after high 
cervical spine injury. Initially the patients are threatened by acute loss 
of motor function of the respiratory muscles and the development of 
neurogenic pulmonary edema. In the further course alterations in the 
mechanical properties of the respiratory system, changes in lung function, 
pulmonary infections and airway problems are the main reasons for life 
threatening respiratory failure. Early surgical stabilization, careful 
weaning from mechanical ventilation, meticulous search and treatment of 
infections, aggressive posturing and mobilization and support of impaired 
mechanical functions by physiotherapy, muscle training, noninvasive 
respiratory support and in some cases electrophrenic pacing increase 
survival and independency of quadriplegic patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; respiratory failure (complication); 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; conference paper; human; lung infection (complication); muscle training; physiotherapy; quadriplegia; tracheotomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English, German
EMBASE ACCESSION NUMBER
  1998331663
MEDLINE PMID
  9793165 (http://www.ncbi.nlm.nih.gov/pubmed/9793165)
PUI
  L28451874
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00367672&id=doi:&atitle=Respiratory+problems+after+high+cervical+spine+injury&stitle=Schweiz.+Med.+Wochenschr.&title=Schweizerische+Medizinische+Wochenschrift&volume=128&issue=39&spage=1462&epage=1466&aulast=Stocker&aufirst=R.&auinit=R.&aufull=Stocker+R.&coden=SMWOA&isbn=&pages=1462-1466&date=1998&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 978
TITLE
  Oxyhemoglobin desaturation and aberrant carbon dioxide homeostasis during 
electrically stimulated exercise in a ventilator-dependent tetraplegic 
patient
AUTHOR NAMES
  Nash M.S.; Jacobs P.L.; Klerk K.M.; Green B.A.
AUTHOR ADDRESSES
  (Nash M.S.) Dept. of Orthopaedics and Rehab., University of Miami, School of 
Medicine, Miami, FL, United States.
(Green B.A.) Department of Neurological Surgery, University of Miami, School 
of Medicine, Miami, FL, United States.
(Nash M.S.; Jacobs P.L.; Green B.A.) Miami Project to Cure Paralysis, 
University of Miami, School of Medicine, Miami, FL, United States.
(Klerk K.M.) Department of Physical Therapy, University of Miami, Jackson 
Memorial Medical Center, Miami, FL, United States.
(Nash M.S.) Division of Physical Therapy, Dept. of Orthopaedics and Rehab., 
Univ. of Miami School of Medicine, 5915 Ponce de Leon Boulevard, Coral 
Gables, FL 33146, United States.
CORRESPONDENCE ADDRESS
  M.S. Nash, Division of Physical Therapy, Dept. of 
Orthopaedics/Rehabilitation, Univ. of Miami School of Medicine, 5915 Ponce 
de Leon Boulevard, Coral Gables, FL 33146, United States.
FULL RECORD ENTRY DATE
  1998-09-04
SOURCE
  Archives of Physical Medicine and Rehabilitation (1998) 79:7 (873-876). Date 
of Publication: July 1998
VOLUME
  79
ISSUE
  7
FIRST PAGE
  873
LAST PAGE
  876
DATE OF PUBLICATION
  July 1998
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  This single-subject case examined oxyhemoglobin saturation and alveolar 
end-tidal carbon dioxide levels in a ventilator-dependent tetraplegic 
patient undergoing electrical stimulation cycle ergometry. When exercising 
with a closed tracheostomy cuff under resting ventilator settings (resting 
intermittent mandatory ventilation; frequency = 6breaths/min, tidal volume = 
83.3mL, minute ventilation =5L/min), his oxyhemoglobin saturation decreased 
from 100% to 92%, while alveolar end-tidal carbon dioxide increased linearly 
to 47mmHg. These undesirable changes were corrected under adjusted 
intermittent mandatory ventilation conditions (frequency = 12breaths/min, 
tidal volume = 83.3mL, minute ventilation = 10L/min), during which 
oxyhemoglobin saturation remained above 98% and the alveolar end-tidal 
carbon dioxide trend resembled that of ventilator-independent tetraplegic 
individuals undergoing the same exercise. Because the subject's heart rate 
was higher under adjusted ventilation conditions, these responses may have 
been caused by augmented venous return resulting from greater 
abdominothoracic pumping at the higher breathing frequency. These findings 
support the need to modify ventilator settings in ventilator-dependent 
tetraplegic persons while undergoing exercise to maintain oxyhemoglobin 
saturation and carbon dioxide homeostasis.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  carbon dioxide; oxyhemoglobin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  capnometry; electrostimulation; oxygen saturation; quadriplegia (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; case report; ergometry; heart rate; human; human tissue; lung ventilation; male; spinal cord injury; treatment indication; treatment outcome; venous return; 
CAS REGISTRY NUMBERS
  carbon dioxide (124-38-9, 58561-67-4)
  oxyhemoglobin (9061-63-6)
EMBASE CLASSIFICATIONS
  Physiology (2)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1998234479
MEDLINE PMID
  9685107 (http://www.ncbi.nlm.nih.gov/pubmed/9685107)
PUI
  L28322155
DOI
  10.1016/S0003-9993(98)90372-0
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-9993(98)90372-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2FS0003-9993%2898%2990372-0&atitle=Oxyhemoglobin+desaturation+and+aberrant+carbon+dioxide+homeostasis+during+electrically+stimulated+exercise+in+a+ventilator-dependent+tetraplegic+patient&stitle=Arch.+Phys.+Med.+Rehabil.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=79&issue=7&spage=873&epage=876&aulast=Nash&aufirst=Mark+S.&auinit=M.S.&aufull=Nash+M.S.&coden=APMHA&isbn=&pages=873-876&date=1998&auinit1=M&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 979
TITLE
  Spine surgery in Duchenne muscular dystrophy
ORIGINAL (NON-ENGLISH) TITLE
  La chirurgie du rachis dans la dystrophie musculaire de Duchenne
AUTHOR NAMES
  Chataigner H.; Grelet V.; Onimus M.
AUTHOR ADDRESSES
  (Chataigner H.; Grelet V.; Onimus M.) Serv. Chir. Scolioses/Orthoped. Inf., 
Hôpital Saint-Jacques, 25030 Besançon Cedex.
CORRESPONDENCE ADDRESS
  M. Onimus, Service de Chirurgie des Scolioses, Orthopedie Infantile, Hopital 
Saint-Jacques, 25030 Besancon Cedex, France.
FULL RECORD ENTRY DATE
  1998-06-22
SOURCE
  Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur (1998) 
84:3 (224-230). Date of Publication: 1998
VOLUME
  84
ISSUE
  3
FIRST PAGE
  224
LAST PAGE
  230
DATE OF PUBLICATION
  1998
ISSN
  0035-1040
BOOK PUBLISHER
  Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex, 
France.
ABSTRACT
  Purpose of the study: The authors present a retrospective review of 27 
patients presenting a Duchenne muscular dystrophy and who were operated for 
spinal deformity, with special reference to functional result and 
postoperative evolution of vital capacity. Material and methods: Age at 
surgery averaged-14. Mean scoliotic angulation was 42°. A thoraco-lumbar 
kyphosis was present in 15 cases (kyphotic index less than 10°). A pelvic 
obliquity averaging 17°was associated in 19 cases. Mean pre-operative vital 
capacity was 66 per cent. Preoperative evolution of vital capacity was 
documented in 18 cases annual rate of decrease was 4.3 per cent. Heart 
ejection fraction averaged 63 per cent in 23 cases, and was normal in 4 
cases. Instrumentation was extented from D3, D4 or D5 to L5 (5 cases) or S1 
(22 cases). Spinal fixation was done in all patients by subliminar wiring 
with Luque rods (5 cases) or Hartshill rectangle (22 cases). Sacral fixation 
was done with ilio-sacral screws linked to the rectangle by Cotrel Dubousset 
rods and dominos (15 cases). Results: Mean blood loss was 1750 cc. 
Postoperatively, 25 patients were extubated on the operative day, 1 patient 
at D+1, and one patient a tracheostomy after one month. Scoliosis was 
reduced to 10°after surgery and 13°after 30 months follow-up. Pelvic 
obliquity was reduced to 4°after surgery and 7°after 30 months. A good 
spinal balance was present after surgery in 20 patients; at follow-up, a 
coronal or sagittal imbalance averaging 40 mm was observed in 22 patients. 
Postoperative evolution of vital capacity was documented in 21 cases. The 
annual decrease rate was 6.4 per cent. Rate was higher in patients 
presenting a good preoperative vital capacity (over 70 per cent) and very 
low in patients presenting a preoperative vital capacity under 40 per cent. 
10 patients were deceased at review after a mean 53 months survival, at a 
mean age of 19. 17 patients were alive with a 50 months follow-up. 
Discussion: Spinal surgery in Duchenne muscular dystrophy has a low 
morbidity. It allows to keep sitting position to the child and to preserve 
quality of life. Surgery should be considered as soon as frontal or sagittal 
collapse of the spine is observed. However surgery does not result in 
respiratory improvement nor in life duration lengthening.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Duchenne muscular dystrophy (surgery); spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adult; article; clinical article; female; human; male; quality of life; scoliosis; spine malformation (surgery); surgical technique; survival; tracheostomy; vital capacity; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English, French
EMBASE ACCESSION NUMBER
  1998189036
MEDLINE PMID
  9775044 (http://www.ncbi.nlm.nih.gov/pubmed/9775044)
PUI
  L28261666
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00351040&id=doi:&atitle=Spine+surgery+in+Duchenne+muscular+dystrophy&stitle=Rev.+Chir.+Orthop.+Repar.+Appar.+Mot.&title=Revue+de+Chirurgie+Orthopedique+et+Reparatrice+de+l%27Appareil+Moteur&volume=84&issue=3&spage=224&epage=230&aulast=Chataigner&aufirst=H.&auinit=H.&aufull=Chataigner+H.&coden=RCORA&isbn=&pages=224-230&date=1998&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 980
TITLE
  Esophageal injury secondary to thoracic spinal trauma: The need for early 
diagnosis and aggressive surgical treatment
AUTHOR NAMES
  Nakai S.; Yoshizawa H.; Kobayashi S.; Miyachi M.
AUTHOR ADDRESSES
  (Nakai S.; Yoshizawa H.; Kobayashi S.) Department of Orthopedics, School of 
Medicine, Fujita Health University, Toyoake, Japan.
(Miyachi M.) Miyachi Orthopedic Hospital, Toyokawa, Japan.
(Nakai S.) Department of Orthopedics, School of Medicine, Fujita Health 
University, Dengakugakubo 1-98, Kutsukakecho, Toyoake, Aichi 470-11, Japan.
CORRESPONDENCE ADDRESS
  S. Nakai, Department of Orthopedics, School of Medicine, Fujita Health 
University, Dengakugakubo 1-98, Kutsukakecho, Toyoake, Aichi 470-11, Japan.
FULL RECORD ENTRY DATE
  1998-08-04
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (1998) 44:6 
(1086-1089). Date of Publication: June 1998
VOLUME
  44
ISSUE
  6
FIRST PAGE
  1086
LAST PAGE
  1089
DATE OF PUBLICATION
  June 1998
ISSN
  1079-6061
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  esophagus injury (diagnosis); spine injury; thoracic spine; 
EMTREE MEDICAL INDEX TERMS
  adult; autopsy; case report; conference paper; disseminated intravascular clotting; esophagus fistula (diagnosis); esophagus perforation (diagnosis); female; human; priority journal; respiratory distress; rib fracture; thorax drainage; tracheotomy; traffic accident; vertebra dislocation; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Orthopedic Surgery (33)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1998226807
MEDLINE PMID
  9637167 (http://www.ncbi.nlm.nih.gov/pubmed/9637167)
PUI
  L28310974
DOI
  10.1097/00005373-199806000-00024
FULL TEXT LINK
  http://dx.doi.org/10.1097/00005373-199806000-00024
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10796061&id=doi:10.1097%2F00005373-199806000-00024&atitle=Esophageal+injury+secondary+to+thoracic+spinal+trauma%3A+The+need+for+early+diagnosis+and+aggressive+surgical+treatment&stitle=J.+Trauma+Inj.+Infect.+Crit.+Care&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=44&issue=6&spage=1086&epage=1089&aulast=Nakai&aufirst=Sadaaki&auinit=S.&aufull=Nakai+S.&coden=JOTRF&isbn=&pages=1086-1089&date=1998&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 981
TITLE
  COPD and other diseases in chronically ventilated patients in a prolonged 
respiratory care unit: A retrospective 20-year survival study
AUTHOR NAMES
  Votto J.; Brancifort J.M.; Scalise P.J.; Wollschlager C.M.; ZuWallack R.L.
AUTHOR ADDRESSES
  (Votto J.) 2150 Corbin Ave, New Britain, CT 06053, United States.
(Brancifort J.M.; Scalise P.J.; Wollschlager C.M.; ZuWallack R.L.)
CORRESPONDENCE ADDRESS
  J. Votto, 2150 Corbin Ave, New Britain, CT 06053, United States.
FULL RECORD ENTRY DATE
  1998-02-17
SOURCE
  Chest (1998) 113:1 (86-90). Date of Publication: 1998
VOLUME
  113
ISSUE
  1
FIRST PAGE
  86
LAST PAGE
  90
DATE OF PUBLICATION
  1998
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Objectives: To evaluate the long-term prognosis of ventilator-dependent 
patients. Design: Retrospective study. Setting: A prolonged respiratory care 
unit (PRCU). The PRCU provides comprehensive medical, nursing, and 
respiratory care to tracheostomized, ventilator-dependent adult patients who 
had failed all attempts at weaning. Because of their medical complexity, 
these patients could not be discharged to a lower level of care. Patients: 
Of the 293 patients admitted to the PRCU over a 20-year period beginning 
January 1, 1977, 145 had respiratory failure from COPD, 22 from spinal cord 
disease or trauma, 34 from primary CNS disease, 50 from primary 
neuromuscular disease, and 16 from chest wall disease. Twenty-six patients 
were not classifiable into the above categories. Measurements: Demographics, 
diagnoses, and survival data were reviewed. The survival of patients with 
COPD was compared with the other diagnosis categories using the Cox 
proportional hazards model. Results: The median survival for the entire 
group was 9 months; younger age and female gender were both predictive of 
longer survival (both, p < 0.001). The median survival of those with COPD (5 
months) was significantly shorter than that of patients with spinal cord 
disease (47 months), neuromuscular disease (17 months), and chest wall 
disease (27 months) (all, p<0.01). These differences in survival were 
present even with inclusion of gender and age in the model as covariates. 
The survival of patients with CNS disease was not significantly different 
from survival of patients with COPD. Conclusion: Chronically ventilated 
patients with respiratory failure from COPD have a significantly worse 
prognosis than patients with respiratory failure from other causes.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  chronic obstructive lung disease; respiratory failure (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis; article; chronic disease; female; human; major clinical study; male; neuromuscular disease; priority journal; prognosis; survival rate; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1998030652
MEDLINE PMID
  9440573 (http://www.ncbi.nlm.nih.gov/pubmed/9440573)
PUI
  L28044929
DOI
  10.1378/chest.113.1.86
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.113.1.86
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.113.1.86&atitle=COPD+and+other+diseases+in+chronically+ventilated+patients+in+a+prolonged+respiratory+care+unit%3A+A+retrospective+20-year+survival+study&stitle=Chest&title=Chest&volume=113&issue=1&spage=86&epage=90&aulast=Votto&aufirst=John&auinit=J.&aufull=Votto+J.&coden=CHETB&isbn=&pages=86-90&date=1998&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 982
TITLE
  Ventilation
ORIGINAL (NON-ENGLISH) TITLE
  Beatmung
AUTHOR NAMES
  Burchardi H.; Wöbker G.; Engelhardt W.; Schregel W.; Spiss C.K.
AUTHOR ADDRESSES
  (Burchardi H.; Wöbker G.; Engelhardt W.; Schregel W.; Spiss C.K.)
FULL RECORD ENTRY DATE
  1997-08-08
SOURCE
  Zentralblatt fur Neurochirurgie (1997) 58:2 (76-82). Date of Publication: 
1997
VOLUME
  58
ISSUE
  2
FIRST PAGE
  76
LAST PAGE
  82
DATE OF PUBLICATION
  1997
ISSN
  0044-4251
BOOK PUBLISHER
  MVS Medizinverlage Stuttgart, Steiermarkerstr. 3-5, Stuttgart, Germany.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; intubation; 
EMTREE MEDICAL INDEX TERMS
  article; brain perfusion; disease severity; intracranial pressure; spinal cord injury; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  German
EMBASE ACCESSION NUMBER
  1997219579
MEDLINE PMID
  9334124 (http://www.ncbi.nlm.nih.gov/pubmed/9334124)
PUI
  L27307051
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00444251&id=doi:&atitle=Ventilation&stitle=ZENTRALBL.+NEUROCHIR.&title=Zentralblatt+fur+Neurochirurgie&volume=58&issue=2&spage=76&epage=82&aulast=Burchardi&aufirst=H.&auinit=H.&aufull=Burchardi+H.&coden=ZENEA&isbn=&pages=76-82&date=1997&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 983
TITLE
  Phrenic pacing: The present and future
ORIGINAL (NON-ENGLISH) TITLE
  Gegenwart und Zukunft des Atemschrittmachers
AUTHOR NAMES
  Thoma H.; Girsch W.; Holle J.; Unger E.
AUTHOR ADDRESSES
  (Unger E.) Inst. F. Biomed. Technik und Physik, Universität Wien, .
(Thoma H.) Inst. F. Biomed. Technik und Physik, Währinger Gürtel 18-20/4L, 
A-1090 Wien, Austria.
(Girsch W.; Holle J.)
CORRESPONDENCE ADDRESS
  H. Thoma, Inst. Biomedizinische Technik/Physik, Wahringer Gurtel 18-20, 
A-1090 Wien, Austria.
FULL RECORD ENTRY DATE
  1997-06-19
SOURCE
  Medizinische Klinik (1997) 92:SUPPL. 1 (77-81). Date of Publication: 28 Apr 
1997
VOLUME
  92
ISSUE
  SUPPL. 1
FIRST PAGE
  77
LAST PAGE
  81
DATE OF PUBLICATION
  28 Apr 1997
ISSN
  0723-5003
BOOK PUBLISHER
  Urban und Vogel GmbH, Neumarkter Strasse 43, Munchen, Germany.
ABSTRACT
  Under certain conditions, phrenic pacing is a rare but most effective and 
attractive alternative for long-term ventilation. General indications 
concern diseases of the breathing center, for example Undine's disease (loss 
of CO(2) sensitivity) in infants and high cervical spinal cord lesions in 
the level of C0 to C3. Despite of the advantage of physiologic respiration 
mode (no positive air pressure) compared to long-term ventilation, the 
phrenic pacemaker enables high life quality for the patients due to 
possibilities of closing of tracheostoma (Vienna system), an optimum in 
mobility and high cost effectiveness. International research and development 
in this area concerns 1. nerve transposition of an innervated nerve to a 
denervating phrenic nerve, 2. additional stimulation of thoracal muscles for 
inspiration, 3. additional stimulation of expiration, 4. endoscopic 
operative positioning of the electrodes, 5. development of a pacer with 
sensor input for an individual respiration rhythm (controlled by the vocal 
cord) and 6. development of a fully implantable system. Improvements of the 
present pacemaker system may lead to enlargement of indications, for example 
use in patients with severe nocturnal arrhythmias in respiration.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cardiac rhythm management device; phrenic nerve; respiration control; 
EMTREE MEDICAL INDEX TERMS
  conference paper; human; quality of life; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  German, English
EMBASE ACCESSION NUMBER
  1997160579
MEDLINE PMID
  9235482 (http://www.ncbi.nlm.nih.gov/pubmed/9235482)
PUI
  L27225946
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07235003&id=doi:&atitle=Phrenic+pacing%3A+The+present+and+future&stitle=MED.+KLIN.&title=Medizinische+Klinik&volume=92&issue=SUPPL.+1&spage=77&epage=81&aulast=Unger&aufirst=Ewald&auinit=E.&aufull=Unger+E.&coden=MEKLA&isbn=&pages=77-81&date=1997&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 984
TITLE
  Management of concomitant maxillofacial, cervical spine and laryngeal 
trauma--case reports.
AUTHOR NAMES
  Lim T.C.; Mokal N.J.; Tan W.T.
AUTHOR ADDRESSES
  (Lim T.C.; Mokal N.J.; Tan W.T.) Lokmanya Tilak Municipal Medical College 
and Hospital, Department of Plastic and Reconstructive Surgery, Bombay, 
India.
CORRESPONDENCE ADDRESS
  T.C. Lim, Lokmanya Tilak Municipal Medical College and Hospital, Department 
of Plastic and Reconstructive Surgery, Bombay, India.
FULL RECORD ENTRY DATE
  1997-07-21
SOURCE
  Annals of the Academy of Medicine, Singapore (1997) 26:1 (108-112). Date of 
Publication: Jan 1997
VOLUME
  26
ISSUE
  1
FIRST PAGE
  108
LAST PAGE
  112
DATE OF PUBLICATION
  Jan 1997
ISSN
  0304-4602
ABSTRACT
  Three cases are presented to stress important points in the diagnosis and 
management of concomitant maxillofacial, cervical spine and laryngeal 
trauma. Emergency tracheostomy to control airway, immediate rigid fixation 
of maxillofacial fractures, early computed tomographic (CT) scans to 
evaluate the extent of laryngeal and cervical spine injury and the early 
repair of laryngeal injury will provide better aesthetic and functional 
results.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; fracture (therapy); larynx; maxillofacial injury (diagnosis, therapy); multiple trauma (diagnosis, therapy); penetrating trauma (therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; computer assisted tomography; human; injury; injury scale; male; traffic accident; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  9140587 (http://www.ncbi.nlm.nih.gov/pubmed/9140587)
PUI
  L127250962
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03044602&id=doi:&atitle=Management+of+concomitant+maxillofacial%2C+cervical+spine+and+laryngeal+trauma--case+reports.&stitle=Ann.+Acad.+Med.+Singap.&title=Annals+of+the+Academy+of+Medicine%2C+Singapore&volume=26&issue=1&spage=108&epage=112&aulast=Lim&aufirst=T.C.&auinit=T.C.&aufull=Lim+T.C.&coden=&isbn=&pages=108-112&date=1997&auinit1=T&auinitm=C
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 985
TITLE
  Assessment of the motor pathway to the diaphragm using cortical and cervical 
magnetic stimulation in the decision-making process of phrenic pacing
AUTHOR NAMES
  Similowski T.; Straus C.; Attali V.; Duguet A.; Jourdain B.; Derenne J.-P.
AUTHOR ADDRESSES
  (Similowski T.; Straus C.; Attali V.; Duguet A.; Jourdain B.; Derenne J.-P.) 
U. Reanimation Lab. Physiopathol. R., Service de Pneumologie, Grp. Hosp. 
Pitie-Salpetriere, Paris, France.
(Similowski T.) Lab. de Physiopathol. Respiratoire, Service de Pneumologie, 
Grp. Hosp. Pitie-Salpetriere, 47-83, Bd de l'Hôpital, 75651 Paris Cedex 13, 
France.
CORRESPONDENCE ADDRESS
  T. Similowski, Service de Pneumologie/Reanimation, Groupe Hospitalier 
Pitie-Salpetriere, Lab. Physiopathologie Respiratoire, 47-83, Bd de'l 
Hopital, 75651 Paris Cedex 13, France.
FULL RECORD ENTRY DATE
  1997-01-09
SOURCE
  Chest (1996) 110:6 (1551-1557). Date of Publication: 1996
VOLUME
  110
ISSUE
  6
FIRST PAGE
  1551
LAST PAGE
  1557
DATE OF PUBLICATION
  1996
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Background: Phrenic nerve pacing is a recognized substitute to positive 
pressure ventilation via tracheotomy in patients with high cervical cord 
lesions or central hypoventilation. Although its indications are infrequent, 
reliable strategies need to be used in the determinations of patients who 
may benefit from this treatment; contraindications should be carefully 
respected. Study objectives: To determine whether modern and noninvasive 
means to study the motor pathway to the diaphragm, namely cortical magnetic 
stimulation (CxMS) and cervical magnetic stimulation (CMS), can contribute 
to the selection of patients who may benefit from phrenic pacing. Design and 
setting: Prospective study (18 months), on a consecutive basis, of patients 
referred for possible phrenic pacing to 10-bed ICU associated with a 
respiratory neurophysiology laboratory. Patients: Seven patients (high 
cervical cord injury, n=5; central hypoventilation following neurosurgery, 
n=1; idiopathic acquired central hypoventilation, n=1). Intervention, 
measurements, and results: Electromyography of the diaphragm and 
transdiaphragmatic pressure were assessed in response to CxMS and CMS. In 
three cases, no interruption of the corticodiaphragmatic pathway was 
evidenced, the decision of pacing was postponed, and the patients eventually 
recovered a spontaneous breathing activity. In two cases, the diagnosis of 
irreversible peripheral phrenic dysfunction was reached and pacing was 
denied. In two cases, complete interruption of the corticodiaphragmatic 
pathway and integrity of peripheral conduction led to the decision of 
phrenic pacemaker implantation. Conclusion: CxMS and CMS can be used to 
refine the assessment of patients proposed for phrenic pacing. CxMS can 
possibly identify those in whom there is a possibility for eventual 
recovery, and therefore substantiate a decision to postpone the pacing.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; clinical article; decision making; diaphragm; female; human; male; muscle innervation; phrenic nerve; priority journal; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1997002408
MEDLINE PMID
  8989076 (http://www.ncbi.nlm.nih.gov/pubmed/8989076)
PUI
  L26425159
DOI
  10.1378/chest.110.6.1551
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.110.6.1551
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.110.6.1551&atitle=Assessment+of+the+motor+pathway+to+the+diaphragm+using+cortical+and+cervical+magnetic+stimulation+in+the+decision-making+process+of+phrenic+pacing&stitle=CHEST&title=Chest&volume=110&issue=6&spage=1551&epage=1557&aulast=Similowski&aufirst=Thomas&auinit=T.&aufull=Similowski+T.&coden=CHETB&isbn=&pages=1551-1557&date=1996&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 986
TITLE
  Percutaneous dilational tracheostomy after anterior cervical spine fixation
AUTHOR NAMES
  Mazzon D.; Di Stefano E.; Dametto G.; Nizzetto M.; Cippolotti G.; Bosco E.; Conti C.; Giuliani G.
AUTHOR ADDRESSES
  (Mazzon D.; Cippolotti G.; Bosco E.; Giuliani G.) 2nd Dept. Anesthesia 
Intensive Care, S. M. dei Battuti City Hospital, Treviso, Italy.
(Di Stefano E.; Conti C.) Division of Neurosurgery, S. M. dei Battuti City 
Hospital, Treviso, Italy.
(Dametto G.; Nizzetto M.) Department of Pneumology, S. M. dei Battuti City 
Hospital, Treviso, Italy.
(Mazzon D.) 2nd Dept. Anesthesia Intensive Care, S. M. dei Battuti City 
Hospital, 31100 Treviso, Italy.
CORRESPONDENCE ADDRESS
  D. Mazzon, Anesthesia/Intensive Care 2nd Dept., S. M. dei Battuti City 
Hospital, 31100 Treviso, Italy.
FULL RECORD ENTRY DATE
  1996-10-07
SOURCE
  Journal of Neurosurgical Anesthesiology (1996) 8:4 (293-295). Date of 
Publication: 1996
VOLUME
  8
ISSUE
  4
FIRST PAGE
  293
LAST PAGE
  295
DATE OF PUBLICATION
  1996
ISSN
  0898-4921
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  After spinal cord injury, quadriplegic patients generally require 
tracheostomy for ventilatory support and airway clearance. Early 
tracheostomy has several advantages over translaryngeal intubation, but in 
patients who undergo anterior surgical fixation of the spine, it is often 
delayed until after recovery of the surgical wound. We report the case of a 
quadriplegic patient who underwent a successful percutaneous dilational 
tracheostomy with the Ciaglia technique after surgical fixation of the 
spine. The percutaneous dilational technique minimizes the injury to the 
adjacent structures of the neck and the risk of stomal infection. Therefore, 
it should be considered the technique of choice when an early tracheostomy 
is indicated for quadriplegic patients who have undergone anterior surgical 
fixation of the cervical spine.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; spine stabilization; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; case report; human; male; postoperative infection; priority journal; quadriplegia; surgical technique; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996288452
MEDLINE PMID
  8884626 (http://www.ncbi.nlm.nih.gov/pubmed/8884626)
PUI
  L26314015
DOI
  10.1097/00008506-199610000-00006
FULL TEXT LINK
  http://dx.doi.org/10.1097/00008506-199610000-00006
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08984921&id=doi:10.1097%2F00008506-199610000-00006&atitle=Percutaneous+dilational+tracheostomy+after+anterior+cervical+spine+fixation&stitle=J.+NEUROSURG.+ANESTHESIOL.&title=Journal+of+Neurosurgical+Anesthesiology&volume=8&issue=4&spage=293&epage=295&aulast=Mazzon&aufirst=D.&auinit=D.&aufull=Mazzon+D.&coden=JNANE&isbn=&pages=293-295&date=1996&auinit1=D&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 987
TITLE
  Direct injury to the cervical spine of a child by a lap-shoulder belt 
resulting in quadriplegia: Case report
AUTHOR NAMES
  Lynch J.M.; Meza M.P.; Pollack I.F.; Adelson P.D.
AUTHOR ADDRESSES
  (Lynch J.M.) Benedum Pediatric Trauma Program, Children's Hospital of 
Pittsburg, Department of Pediatric Surgery, .
(Lynch J.M.; Pollack I.F.; Adelson P.D.) Department of Trauma, Children's 
Hospital of Pittsburg, Univ. of Pittsburgh Sch. of Medicine, .
(Meza M.P.) Department of Radiology, Children's Hospital of Pittsburg, Univ. 
of Pittsburgh Sch. of Medicine, .
(Pollack I.F.; Adelson P.D.) Department of Neurosurgery, Children's Hospital 
of Pittsburg, Univ. of Pittsburgh Sch. of Medicine, .
(Lynch J.M.) Children's Hospital of Pittsburgh, Department of Pediatric 
Surgery, 3705 Fifth Avenue, Pittsburgh, PA 15213, United States.
CORRESPONDENCE ADDRESS
  J.M. Lynch, Department of Pediatric Surgery, Children's Hospital of 
Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, United States.
FULL RECORD ENTRY DATE
  1996-10-30
SOURCE
  Journal of Trauma - Injury, Infection and Critical Care (1996) 41:4 
(747-749). Date of Publication: October 1996
VOLUME
  41
ISSUE
  4
FIRST PAGE
  747
LAST PAGE
  749
DATE OF PUBLICATION
  October 1996
ISSN
  1079-6061
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Most pediatric cervical spine injuries from seat-belt restraints result from 
hyperflexion of the neck without direct injury to the spine from the 
restraining device. We report what we believe to be the first case of direct 
injury to the cervical spine by the shoulder component of a lap-shoulder 
seat belt. This resulted in quadriplegia. The mechanism of injury and 
recommendations to obviate such injuries are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury (etiology, surgery); quadriplegia (complication); seatbelt injury (etiology); 
EMTREE MEDICAL INDEX TERMS
  article; case report; clinical feature; female; human; larynx injury (complication); preschool child; priority journal; spine fusion; spine stabilization; tracheostomy; traffic accident; treatment outcome; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Surgery (9)
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996318596
MEDLINE PMID
  8858040 (http://www.ncbi.nlm.nih.gov/pubmed/8858040)
PUI
  L26346312
DOI
  10.1097/00005373-199610000-00026
FULL TEXT LINK
  http://dx.doi.org/10.1097/00005373-199610000-00026
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10796061&id=doi:10.1097%2F00005373-199610000-00026&atitle=Direct+injury+to+the+cervical+spine+of+a+child+by+a+lap-shoulder+belt+resulting+in+quadriplegia%3A+Case+report&stitle=J.+TRAUMA+INJ.+INFECT.+CRIT.+CARE&title=Journal+of+Trauma+-+Injury%2C+Infection+and+Critical+Care&volume=41&issue=4&spage=747&epage=749&aulast=Lynch&aufirst=James+M.&auinit=J.M.&aufull=Lynch+J.M.&coden=JOTRF&isbn=&pages=747-749&date=1996&auinit1=J&auinitm=M
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 988
TITLE
  Massive tongue swelling as a complication after spinal surgery
AUTHOR NAMES
  Miura Y.; Mimatsu K.; Iwata H.
AUTHOR ADDRESSES
  (Miura Y.; Mimatsu K.; Iwata H.) Department of Orthopaedic Surgery, Nagoya 
University, School of Medicine, Nagoya, Japan.
(Miura Y.) Department of Orthopaedic Surgery, Nagoya University, School of 
Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466, Japan.
CORRESPONDENCE ADDRESS
  Y. Miura, Department of Orthopaedic Surgery, Nagoya University School of 
Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466, Japan.
FULL RECORD ENTRY DATE
  1996-09-25
SOURCE
  Journal of Spinal Disorders (1996) 9:4 (339-341). Date of Publication: 1996
VOLUME
  9
ISSUE
  4
FIRST PAGE
  339
LAST PAGE
  341
DATE OF PUBLICATION
  1996
ISSN
  0895-0385
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  We report four cases of massive tongue swelling after spinal surgery. 
Swelling resulted from the position of the spine during surgery (flexed 
thoracic cervical position), fixation of the endotracheal tube, additional 
surgical gauzes packed around the endotracheal tube, and compression of the 
base of the tongue. Swelling, which causes obstruction of the airway, is a 
severe complication after spinal surgery that sometimes requires a 
tracheotomy. This complication can be avoided by careful positioning of the 
patient and by fixation of the endotracheal tube before surgery. Once 
swelling of the tongue occurs, administration of a corticosteroid is 
effective in preventing constriction of the airway.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  corticosteroid (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  edema (complication); spine surgery; tongue disease (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; airway obstruction (drug therapy, prevention); article; case report; endotracheal tube; human; male; patient positioning; postoperative complication; priority journal; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996276844
MEDLINE PMID
  8877963 (http://www.ncbi.nlm.nih.gov/pubmed/8877963)
PUI
  L26299040
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08950385&id=doi:&atitle=Massive+tongue+swelling+as+a+complication+after+spinal+surgery&stitle=J.+SPINAL+DISORD.&title=Journal+of+Spinal+Disorders&volume=9&issue=4&spage=339&epage=341&aulast=Miura&aufirst=Yasushi&auinit=Y.&aufull=Miura+Y.&coden=JSDIE&isbn=&pages=339-341&date=1996&auinit1=Y&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 989
TITLE
  The prognosis and the treatment of patients with a C3/4 spinal cord injury
AUTHOR NAMES
  Sannohe A.; Harata S.; Ueyama K.; Ito J.; Sato T.; Tian W.; Ichikawa S.
AUTHOR ADDRESSES
  (Sannohe A.; Harata S.; Ueyama K.; Ito J.; Sato T.; Tian W.) Department of 
Orthopaedic Surgery, Hirosaki Univ. School of Medicine, 5, Zaifu-cho, 
Hirosaki, 036, Japan.
(Ichikawa S.) Department of Orthopaedic Surgery, Hirosaki Memorial Hospital, 
1-59, Nisida, Sakaizeki, Hirosaki, 036, Japan.
CORRESPONDENCE ADDRESS
  A. Sannohe, Department of Orthopaedic Surgery, Hirosaki University School 
Medicine, 5 Zaifu-cho, Hirosaki 036, Japan.
FULL RECORD ENTRY DATE
  1996-09-10
SOURCE
  Spinal Cord (1996) 34:8 (486-487). Date of Publication: 1996
VOLUME
  34
ISSUE
  8
FIRST PAGE
  486
LAST PAGE
  487
DATE OF PUBLICATION
  1996
ISSN
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Twenty patients with a C3/4 spinal cord injury have been treated in our 
hospital since 1974. There were 15 new patients. The average follow up 
period was 68 months, ranging from 7 to 162 months. The 15 new cases were 
classified as Frankel A in nine cases, B in one, and C in five. Frankel A or 
B were usually accompanied by either an unstable spinal fracture or by 
spinal canal stenosis at the C3/4 level. Twelve patients received surgery. 
At the most recent follow up, eight of the 15 patients (53.3%) had improved 
according to Frankel's classification. Five, all Frankel A on remission, 
have died between 2 and 156 months after injury. Seven patients required 
tracheotomy on account of severe respiratory disturbance.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury (rehabilitation, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; clinical article; female; follow up; human; injury scale; male; priority journal; prognosis; respiratory failure (complication, surgery); tracheotomy; vertebral canal stenosis (complication); 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996262096
MEDLINE PMID
  8856856 (http://www.ncbi.nlm.nih.gov/pubmed/8856856)
PUI
  L26283742
DOI
  10.1038/sc.1996.83
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.1996.83
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.1996.83&atitle=The+prognosis+and+the+treatment+of+patients+with+a+C3%2F4+spinal+cord+injury&stitle=SPINAL+CORD&title=Spinal+Cord&volume=34&issue=8&spage=486&epage=487&aulast=Sannohe&aufirst=A.&auinit=A.&aufull=Sannohe+A.&coden=SPCOF&isbn=&pages=486-487&date=1996&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 990
TITLE
  Methicillin-resistant Staphylococcus aureus: A four-year experience in a 
spinal cord injury unit in Spain
AUTHOR NAMES
  Olona-Cabases M.; Ticó-Falguera N.; Ramírez-Garcerán L.; Del Valle-Ortiz O.; Castelló-Verdú T.; García-Fernández L.
AUTHOR ADDRESSES
  (Ticó-Falguera N.; Ramírez-Garcerán L.; Castelló-Verdú T.; García-Fernández 
L.) Spinal Cord Injury Unit, Traumatology and Rehab. Univ. Hosp., Ciutat 
Sanit. Univ. Vall d'Hebron, Psg. Vall d'Hebron 119-129, 08035 Barcelona, 
Spain.
(Olona-Cabases M.) Prev. Med. and Epidemiology Service, Ciutat Sanit. Univ. 
Vall d'Hebron, .
(Del Valle-Ortiz O.) Microbiology Service, Ciutat Sanit. Univ. Vall 
d'Hebron, .
CORRESPONDENCE ADDRESS
  L. Garcia-Fernandez, Spinal Cord Injury Unit, Traumatology/Rehab. Univ. 
Hosp., Ciutat Sanitaria Univ. Vall d'Hebron, Psg. Vall d'Hebron 119-129, 
08035 Barcelona, Spain.
FULL RECORD ENTRY DATE
  1996-07-24
SOURCE
  Spinal Cord (1996) 34:6 (315-319). Date of Publication: 1996
VOLUME
  34
ISSUE
  6
FIRST PAGE
  315
LAST PAGE
  319
DATE OF PUBLICATION
  1996
ISSN
  1362-4393
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Methicillin-Resistant Staphylococcus aureus (MRSA) infection poses a problem 
for both acute and long-term-care facilities, Spinal Cord Injury units 
included. This paper describes the 4-year evolution of MRSA outbreaks in a 
SCI unit in a university hospital where control measures were implemented 
from the first case detected. The protocol procedure was as follows: contact 
isolation, washing with antiseptic soap both those infected and those 
sharing the same room, contacts study and monitoring of MRSA patients up to 
the time when three consecutive negative cultures (sampled at time lapses of 
over 48 h) were obtained, antiseptic soap for the health-care personnel to 
wash their hands, and cultures of the nares done on the personnel in the 
event of an outbreak. Twenty-one (3.4%) MRSA positive cases were detected 
out of 550 admissions registered during the study period (November 1990 
through October l994). The evolution occurred in three outbreaks and six 
isolated MRSA positive patients without secondary cases. 71.5% of the cases 
were nosocomial. Seven (33%) were colonized and 14 (67%) infected. The 14 
patients infected presented 15 infections: nine with urinary tract 
infections, three surgical wound infections, two tracheostomy wound 
infections, and one patient with a decubitus ulcer infection. Two of those 
with urinary tract infections presented with secondary sepsis. No carriers 
were detected amongst the personnel. Urinary tract colonizations responded 
to treatment with cotrimoxazol except in two cases in which combined 
treatment was required (cotrimoxazol plus rifampicin). The patients with a 
MRSA positive tracheal aspirate were negative after combined treatment. 
Wounds and cultures of the nares responded favorably to initial treatment. 
One of the patients with a urinary tract infection and sepsis died, the 
infection being a contributing cause. The prospective follow-up of the 
patients with MRSA positive cultures and the precocious implementation of 
isolation measures allow for the limitation of transmission, even though 
complete eradication is not possible.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cotrimoxazole (drug combination, drug therapy); meticillin; rifampicin (drug combination, drug therapy); 
EMTREE DRUG INDEX TERMS
  amikacin; chloramphenicol; ciprofloxacin; erythromycin; fosfomycin (drug combination, drug therapy); fusidic acid; gentamicin; lincosamine; norfloxacin; tobramycin; unclassified drug; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bacterial infection (drug therapy, prevention); drug resistance; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  article; controlled study; human; major clinical study; priority journal; Staphylococcus aureus; 
CAS REGISTRY NUMBERS
  amikacin (37517-28-5, 39831-55-5)
  chloramphenicol (134-90-7, 2787-09-9, 56-75-7)
  ciprofloxacin (85721-33-1)
  cotrimoxazole (8064-90-2)
  erythromycin (114-07-8, 70536-18-4)
  fosfomycin (23155-02-4)
  fusidic acid (6990-06-3)
  gentamicin (1392-48-9, 1403-66-3, 1405-41-0)
  lincosamine (13006-69-4)
  meticillin (132-92-3, 38882-79-0, 61-32-5)
  norfloxacin (70458-96-7)
  rifampicin (13292-46-1)
  tobramycin (32986-56-4)
EMBASE CLASSIFICATIONS
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Neurology and Neurosurgery (8)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996196499
MEDLINE PMID
  8963983 (http://www.ncbi.nlm.nih.gov/pubmed/8963983)
PUI
  L26202835
DOI
  10.1038/sc.1996.58
FULL TEXT LINK
  http://dx.doi.org/10.1038/sc.1996.58
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13624393&id=doi:10.1038%2Fsc.1996.58&atitle=Methicillin-resistant+Staphylococcus+aureus%3A+A+four-year+experience+in+a+spinal+cord+injury+unit+in+Spain&stitle=SPINAL+CORD&title=Spinal+Cord&volume=34&issue=6&spage=315&epage=319&aulast=Tic%C3%B3-Falguera&aufirst=N.&auinit=N.&aufull=Tic%C3%B3-Falguera+N.&coden=SPCOF&isbn=&pages=315-319&date=1996&auinit1=N&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 991
TITLE
  Anterior extraoral surgery to the upper cervical spine
AUTHOR NAMES
  Laus M.; Pignatti G.; Malaguti M.C.; Alfonso C.; Zappoli F.A.; Giunti A.
AUTHOR ADDRESSES
  (Laus M.) Orthopaedic Department, S. Orsola-Malpighi Hospital, Bologna, 
Italy.
(Pignatti G.; Alfonso C.; Zappoli F.A.; Giunti A.) Orthopaedic Department, 
University of Bologna, Istituto Ortopedico Rizzoli, Bologna, Italy.
(Malaguti M.C.) Department of Radiology, Istituto Ortopedico Rizzoli, 
Bologna, Italy.
(Laus M.) Div. di Ortopedia e Traumatologia, Policlinico S. Orsola - 
Malpighi, via Albertoni 15, 40138 Bologna, BO, Italy.
CORRESPONDENCE ADDRESS
  M. Laus, Div. di Ortopedia e Traumatologia, Policlinico S. Orsola - 
Malpighi, via Albertoni 15, 40138 Bologna BO, Italy.
FULL RECORD ENTRY DATE
  1996-09-30
SOURCE
  Spine (1996) 21:14 (1687-1693). Date of Publication: 15 Jul 1996
VOLUME
  21
ISSUE
  14
FIRST PAGE
  1687
LAST PAGE
  1693
DATE OF PUBLICATION
  15 Jul 1996
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Study Design. A series of 10 patients surgically treated with prevascular or 
retrovascular extraoral retropharyngeal approach to the upper cervical spine 
is examined. Objectives. In orthopedic surgery, retropharyngeal approach may 
replace the transoral surgery, obviating the risks of infection and the 
uncomfortable postoperative course of cases in which median labiomandibular 
glossotomy was used to accomplish complex bone reconstruction. Summary of 
the Background Data. The transoral approach is reported in literature as the 
classical anterior access to the upper cervical spine that provides direct 
exposure for anterior decompression of the spinal cord. The risks, the 
surgical limits, and the postoperative difficulties of transmucosal access 
suggest the use of an anterior extraoral retropharyngeal approach in 
orthopedic surgery. Methods. The series includes four neoplastic lesions 
(osteoma, aneurismal bone cyst, giant cell tumor, solitary metastasis), 
three retropharyngeal ossifications resulting from diffuse idiopathic 
skeletal hyperostosis, and a single case of os odontoideum, craniocervical 
malformation, and postlaminectomy kyphosis. Results. At follow-up 
evaluation, all patients achieved a satisfactory outcome, with good clinical 
and radiographic results; nasotracheal intubation obviated the need for 
tracheostomy. The wide surgical exposure allowed reconstruction with iliac 
strut bone grafts and internal fixation in six patients, avoiding the need 
of a halo device. The only complications were four instances of transient 
palsies of the marginal mandibular branch of the facial nerve. Conclusions. 
In the anterior surgery of the upper cervical spine, the prevascular 
approach allows a wide surgical exposure, with visualization similar to that 
obtained with median labiomandibular glossotomy. The retrovascular approach 
is indicated in selected cases, such as tumor adjacent to the vertebral 
artery and C1-C2 arthrodesis with bilateral transarticular screws according 
to Barbour.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  orthopedic surgery; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; arthrodesis; article; bone graft; bone remodeling; cervical spine; clinical article; facial nerve paralysis (complication); female; human; male; nasotracheal intubation; osteosynthesis; priority journal; spinal cord decompression; surgical technique; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996228550
MEDLINE PMID
  8839473 (http://www.ncbi.nlm.nih.gov/pubmed/8839473)
PUI
  L26250568
DOI
  10.1097/00007632-199607150-00015
FULL TEXT LINK
  http://dx.doi.org/10.1097/00007632-199607150-00015
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:10.1097%2F00007632-199607150-00015&atitle=Anterior+extraoral+surgery+to+the+upper+cervical+spine&stitle=SPINE&title=Spine&volume=21&issue=14&spage=1687&epage=1693&aulast=Laus&aufirst=Massimo&auinit=M.&aufull=Laus+M.&coden=SPIND&isbn=&pages=1687-1693&date=1996&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 992
TITLE
  Respiratory management, survival, and quality of life for high-level 
traumatic tetraplegics.
AUTHOR NAMES
  Viroslav J.; Rosenblatt R.; Tomazevic S.M.
AUTHOR ADDRESSES
  (Viroslav J.; Rosenblatt R.; Tomazevic S.M.) Dallas Rehabilitation Institute 
of Healthsouth, Texas, USA.
CORRESPONDENCE ADDRESS
  J. Viroslav, Dallas Rehabilitation Institute of Healthsouth, Texas, USA.
FULL RECORD ENTRY DATE
  1997-12-23
SOURCE
  Respiratory care clinics of North America (1996) 2:2 (313-322). Date of 
Publication: Jun 1996
VOLUME
  2
ISSUE
  2
FIRST PAGE
  313
LAST PAGE
  322
DATE OF PUBLICATION
  Jun 1996
ISSN
  1078-5337
ABSTRACT
  Although spinal cord injury is devastating and can compromise the 
respiratory system, particularly when the cervical cord is injured, 
aggressive use of noninvasive respiratory muscle aids can reduce the 
otherwise commonly seen complications of pneumonia, bronchial mucous 
plugging, atelectasis, and respiratory failure. Accessory muscle function 
can also usually be improved and the muscles then recruited to help maintain 
adequate alveolar ventilation during the acute spinal cord injury recovery 
period. Noninvasive assisted ventilation can be successful for patients with 
compromised lung function during the acute rehabilitation period as well as 
on a long-term basis. Removal of an indwelling tracheostomy tube results in 
improved quality of life from many points of view, a decreased number of 
local tracheostomy complications, a decreased number of serious respiratory 
infections, an improved ability to communicate, and an increased ability to 
use the mouth for functions such as operating computers and wheelchairs.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intermittent positive pressure ventilation; quadriplegia (etiology, rehabilitation); quality of life; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; breathing mechanics; devices; female; human; male; methodology; mortality; pathophysiology; review; spinal cord injury (complication); United States (epidemiology); 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  9390885 (http://www.ncbi.nlm.nih.gov/pubmed/9390885)
PUI
  L127332933
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10785337&id=doi:&atitle=Respiratory+management%2C+survival%2C+and+quality+of+life+for+high-level+traumatic+tetraplegics.&stitle=Respir+Care+Clin+N+Am&title=Respiratory+care+clinics+of+North+America&volume=2&issue=2&spage=313&epage=322&aulast=Viroslav&aufirst=J.&auinit=J.&aufull=Viroslav+J.&coden=&isbn=&pages=313-322&date=1996&auinit1=J&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 993
TITLE
  Reconstructive spine surgery in pediatric patients with major loss in vital 
capacity
AUTHOR NAMES
  Rawlins B.A.; Winter R.B.; Lonstein J.E.; Denis F.; Kubic P.T.; Wheeler W.B.; Ozolins A.L.
AUTHOR ADDRESSES
  (Rawlins B.A.; Winter R.B.; Lonstein J.E.; Denis F.) Minnesota Spine Center, 
Minneapolis, MN, United States.
(Kubic P.T.; Ozolins A.L.) St. Paul Children's Hospital, St. Paul, MN, 
United States.
(Wheeler W.B.) Minneapolis Children's Med. Center, Minneapolis, MN, United 
States.
(Winter R.B.) Minnesota Spine Center, 606 24th Ave. South, Minneapolis, MN 
55454-1419, United States.
CORRESPONDENCE ADDRESS
  R.B. Winter, Minnesota Spine Center, 606 24th Ave. South, Minneapolis, MN 
55454-1419, United States.
FULL RECORD ENTRY DATE
  1996-05-06
SOURCE
  Journal of Pediatric Orthopaedics (1996) 16:3 (284-292). Date of 
Publication: 1996
VOLUME
  16
ISSUE
  3
FIRST PAGE
  284
LAST PAGE
  292
DATE OF PUBLICATION
  1996
ISSN
  0271-6798
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Thirty-two pediatric patients with severe restrictive lung disease 
identified with vital capacities <40 of predicted, who had undergone major 
reconstructive spine surgery, were reviewed. There were 18 boys and 14 
girls, the mean age was 13 years (range, 7-17), and the mean vital capacity 
was 31% of predicted (range, 16-39%). Fifty-four procedures were performed 
13 posterior only, one of which was singed, and 19 anterior and posterior 
procedures, of which 15 were staged and four were sequential. The incidence 
of pulmonary complications (pneumonia, reintubation, pneumothorax, 
respiratory arrest, or the need for (tracheostomy) was 19% (six patients), 
and only three patients required tracheostomy. The surgical and 
perioperative mortality rate waszero. Patients who had a thoracotomy or a 
thoracoabdominal approach had a significantly higher number of pulmonary 
complications. The use of preoperative decreased vital capacity as a measure 
of inoperability excludes the young patient most in need of surgical 
intervention. With improved preoperative, intraoperative, and postoperative 
techniques, careful monitoring, and the cooperation of pediatric 
pulmonologists and intensivists, reconstructive spine surgery can be 
performed in the pediatric patient with severe decreased vital capacity with 
very acceptable morbidity and mortality.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spine malformation (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; female; human; lung complication (complication); male; priority journal; respiratory function disorder (complication); school child; spine surgery; surgical mortality; vital capacity; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996127336
MEDLINE PMID
  8728627 (http://www.ncbi.nlm.nih.gov/pubmed/8728627)
PUI
  L26123655
DOI
  10.1097/00004694-199605000-00002
FULL TEXT LINK
  http://dx.doi.org/10.1097/00004694-199605000-00002
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02716798&id=doi:10.1097%2F00004694-199605000-00002&atitle=Reconstructive+spine+surgery+in+pediatric+patients+with+major+loss+in+vital+capacity&stitle=J.+PEDIATR.+ORTHOP.&title=Journal+of+Pediatric+Orthopaedics&volume=16&issue=3&spage=284&epage=292&aulast=Rawlins&aufirst=Bernard+A.&auinit=B.A.&aufull=Rawlins+B.A.&coden=JPORD&isbn=&pages=284-292&date=1996&auinit1=B&auinitm=A
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 994
TITLE
  Laryngotracheal stenosis after intubation or tracheostomy in patients with 
neurological disease
AUTHOR NAMES
  Richard I.; Giraud M.; Perrouin-Verbe B.; Hiance D.; Mauduyt De La Greve I.; Mathé J.-F.
AUTHOR ADDRESSES
  (Richard I.; Giraud M.; Perrouin-Verbe B.; Mauduyt De La Greve I.; Mathé 
J.-F.) Serv. de Reeducation Fonct., Centre Hospitalier Régional, 
Universitaire de Nantes, France.
(Hiance D.) Clin. d'Otorhinolayngologie Chir. C., Centre Hospitalier 
Régional, Universitaire de Nantes, France.
(Richard I.) Serv. de Reeducation Fonct., Ctr. Hosp. Reg. Univ. de Nantes, 
Hôpital St. Jacques, 85 rue St. Jacques, 44035 Nantes Cedex, France.
CORRESPONDENCE ADDRESS
  I. Richard, Service de Reeducation Fonctionnelle, Ctr. Hosp. Regional Univ. 
de Nantes, Hopital St. Jacques, 85 rue St. Jacques, 44035 Nantes cedex, 
France.
FULL RECORD ENTRY DATE
  1996-06-06
SOURCE
  Archives of Physical Medicine and Rehabilitation (1996) 77:5 (493-496). Date 
of Publication: May 1996
VOLUME
  77
ISSUE
  5
FIRST PAGE
  493
LAST PAGE
  496
DATE OF PUBLICATION
  May 1996
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Objective: This retrospective study evaluated the incidence of airway 
complications in neurological patients following translaryngeal intubation, 
tracheostomy, or both. Design: The medical records of 315 consecutive 
patients (200 with traumatic brain injuries, 31 traumatic tetraplegics, and 
84 with other neurological disorders) were reviewed. The type of artificial 
airway, duration of intubation, and use of nocturnal ventilation were 
recorded. Eighty-six percent of the patients underwent some combination of 
tracheal tomograms, flow-volume loop analysis, and fiberoptic 
tracheolaryngoscopy. Stenosis was classified as severe if it required 
surgery, if it required maintaining the tracheostomy, or was lethal. It was 
classified as benign if it was successfully treated by medical or local 
means. Results: Fifty-five percent of the patients were intubated 
translaryngeally only (mean = 17 days). Three percent underwent tracheostomy 
only, and 42% underwent tracheostomy after intubation for a mean of 13 days. 
The overall incidence of airway stenosis was 20%, 1/4 of which was severe. 
Fifteen percent of these patients died as a result of tracheal 
complications. The incidence of stenosis was higher following tracheostomy 
than following intubation only (29% vs 13%, p < .01). The incidence of 
severe stenosis in intubated-only patients was low (1%) compared with that 
following tracheostomy (10%, p < .01). No significant relationship was found 
between the length of intubation or the timing of tracheostomy. Conclusion: 
Fewer complications are associated with transtracheal intubation than with 
tracheostomy. The data suggest that longer periods of intubation be used 
when attempting ventilator weaning before resorting to tracheostomy if 
weaning fails.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury (rehabilitation); endotracheal intubation; larynx stenosis (complication, diagnosis, surgery); spinal cord injury (rehabilitation); trachea stenosis (complication, diagnosis, surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; anesthesia complication; article; child; female; human; intensive care; laryngoscopy; major clinical study; male; neurologic disease (rehabilitation); treatment outcome; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996164415
MEDLINE PMID
  8629927 (http://www.ncbi.nlm.nih.gov/pubmed/8629927)
PUI
  L26158173
DOI
  10.1016/S0003-9993(96)90039-8
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-9993(96)90039-8
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2FS0003-9993%2896%2990039-8&atitle=Laryngotracheal+stenosis+after+intubation+or+tracheostomy+in+patients+with+neurological+disease&stitle=ARCH.+PHYS.+MED.+REHABIL.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=77&issue=5&spage=493&epage=496&aulast=Richard&aufirst=Isabelle&auinit=I.&aufull=Richard+I.&coden=APMHA&isbn=&pages=493-496&date=1996&auinit1=I&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 995
TITLE
  Home mechanical ventilation: investigation of 34 cases in Taiwan.
AUTHOR NAMES
  Lin M.C.; Huang C.C.; Lan R.S.; Tsai Y.H.
AUTHOR ADDRESSES
  (Lin M.C.; Huang C.C.; Lan R.S.; Tsai Y.H.) Department of Internal Medicine, 
Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
CORRESPONDENCE ADDRESS
  M.C. Lin, Department of Internal Medicine, Chang Gung Memorial Hospital, 
Taipei, Taiwan, R.O.C.
FULL RECORD ENTRY DATE
  1997-01-06
SOURCE
  Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical 
journal / Chang Gung Memorial Hospital (1996) 19:1 (42-49). Date of 
Publication: Mar 1996
VOLUME
  19
ISSUE
  1
FIRST PAGE
  42
LAST PAGE
  49
DATE OF PUBLICATION
  Mar 1996
ABSTRACT
  To evaluate the characteristics of and acceptance by persons in Taiwan who 
currently use positive-pressure mechanical ventilation at home (HMV), a 
survey was conducted in August 1992 through home care and equipment 
providers to investigate these patients. The 34 cases enrolled, including 18 
males and 16 females, were classified into four groups: (1) lung disease 
group (LD) (n = 7) including chronic obstructive pulmonary disease and 
bronchiectasis; (2) neuromuscular group (NM) (n = 14) including diverse 
neuromuscular diseases; (3) spinal disease group (SP) (n = 7) including 
spinal cord injuries or tumors and (4) unresponsive stroke group (US) (n = 
6). The average age of the SP group was much younger than those of the other 
three groups. The duration of home ventilation was from 1 to 36 months, with 
a mean duration of 10.6 +/- 8.7 months. Fifteen cases had received HMV for 
more than one year. Twenty six (76.5%) of the patients were completely 
dependent. All of the US patients had to be ventilated all day long in 
contrast to 71.4% of LD completely dependent. The cost of the US group was 
higher than that of the other three groups. Two of the LD, five of NM and 
one US patient had been re-admitted because of pneumonia, tracheostomy wound 
infection, granulation formation or weaning problems before the study. A 
follow-up survey was done four months, then one year later. The survival 
rate was 16.7% for LD group, 50% for NM and US group. Of the SP group, all 
patients were surviving at the end of this study. Most of the present HMV 
users were satisfied with their setting. It was concluded that HMV is an 
acceptable alternative way of therapy for long-term ventilation patients in 
Taiwan. SP and NM patients are better candidates for HMV. The overall one 
year survival rate is promising, while SP patients had the best prognosis. 
Patients who had already used HMV for more than 11 months, regardless of the 
disease, have a better chance to live another year.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; home care; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; child; female; follow up; human; male; middle aged; preschool child; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  8935374 (http://www.ncbi.nlm.nih.gov/pubmed/8935374)
PUI
  L127197035
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Home+mechanical+ventilation%3A+investigation+of+34+cases+in+Taiwan.&stitle=Changgeng+Yi+Xue+Za+Zhi&title=Changgeng+yi+xue+za+zhi+%2F+Changgeng+ji+nian+yi+yuan+%3D+Chang+Gung+medical+journal+%2F+Chang+Gung+Memorial+Hospital&volume=19&issue=1&spage=42&epage=49&aulast=Lin&aufirst=M.C.&auinit=M.C.&aufull=Lin+M.C.&coden=&isbn=&pages=42-49&date=1996&auinit1=M&auinitm=C
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 996
TITLE
  Tracheostomy in the 1990s: Current clinical practice in an urban university 
teaching hospital
AUTHOR NAMES
  Kasper C.L.; Stubbs C.R.; Barton J.A.; Pierson D.J.
AUTHOR ADDRESSES
  (Kasper C.L.; Stubbs C.R.; Pierson D.J.) Respiratory Care Department, 
Harborview Medical Center, .
(Barton J.A.) University of Washington, School of Medicine, Seattle, WA, 
United States.
(Pierson D.J.) Dept. Med., Pulmon. Critical Care M., University of 
Washington, School of Medicine, Seattle, WA, United States.
(Kasper C.L.) Respirators Care Department, 325 Ninth Avenue, 359761, 
Seattle, WA 98104, United States.
CORRESPONDENCE ADDRESS
  C.L. Kasper, Respiratory Care Department, 325 Ninth Avenue, Seattle, WA 
98104, United States.
FULL RECORD ENTRY DATE
  1996-01-31
SOURCE
  Respiratory Care (1996) 41:1 (37-42). Date of Publication: Jan 1996
VOLUME
  41
ISSUE
  1
FIRST PAGE
  37
LAST PAGE
  42
DATE OF PUBLICATION
  Jan 1996
ISSN
  0098-9142
ABSTRACT
  BACKGROUND: Tracheotomy is a commonly performed procedure in hospitals and 
may be performed for various reasons by one of several services. Because of 
the absence of both a defined institution-wide procedure for assessment and 
recent literature to describe current tracheostomy management, we conducted 
this retrospective study. METHODS: We reviewed the medical records of all 
patients for the fiscal year 1992-93 coded as having tracheostomy status 
prior to admission or having tracheotomy performed during the admission. We 
attempted to answer (1) Why were tracheotomies performed? (2) Who 
performed/managed the tracheotomies? (3) What postoperative care was given? 
RESULTS: Of the 109 patients, 74% were men 13 to 83 years of age. Patients 
underwent tracheotomy for facial injuries (21%), prolonged ventilation 
(21%), closed head injuries (20%), other intracranial processes (16%), other 
head and neck surgery (6%), spinal cord injuries (5%), epiglottitis (3%), 
and 8% underwent tracheotomy for reasons other than these. Thirty-seven 
percent were tracked prior to this admission. Of the 93 admissions, 63% had 
tracheotomy performed during the current admission by General Surgery (27%), 
Otolaryngology Head and Neck Surgery (46%), Neurosurgery (22%), Oral and 
Maxillofacial Surgery (2%), Burns-Plastic Surgery (3%). Of the patients with 
tracheostomies 67% had orders and 85% had progress notes pertaining to 
tracheostomy management. Of the 147 admissions, 100 (68%) had Respiratory 
Care notes regarding tracheostomy. CONCLUSION: Because a number of services 
with various training backgrounds participate in the care of patients with 
tracheostomy and because variation exists, a multidisciplinary tracheostomy 
team appears desirable in a hospital such as ours.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tracheostomy; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; assisted ventilation; clinical protocol; face injury; female; head and neck surgery; head injury; human; major clinical study; male; medical practice; treatment planning; university hospital; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1996029872
PUI
  L26026691
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00989142&id=doi:&atitle=Tracheostomy+in+the+1990s%3A+Current+clinical+practice+in+an+urban+university+teaching+hospital&stitle=RESPIR.+CARE&title=Respiratory+Care&volume=41&issue=1&spage=37&epage=42&aulast=Kasper&aufirst=Carol+L.&auinit=C.L.&aufull=Kasper+C.L.&coden=RECAC&isbn=&pages=37-42&date=1996&auinit1=C&auinitm=L
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 997
TITLE
  Occurrence of infection in anterior cervical fusion for spinal cord injury 
after tracheostomy
AUTHOR NAMES
  Northrup B.E.; Vaccaro A.R.; Rosen J.E.; Balderston R.A.; Cotler J.M.
AUTHOR ADDRESSES
  (Northrup B.E.; Vaccaro A.R.; Rosen J.E.; Balderston R.A.; Cotler J.M.) 
Department of Neurosurgery, 1015 Chestnut Street, Philadelphia, PA 19107, 
United States.
CORRESPONDENCE ADDRESS
  B.E. Northrup, Department of Neurosurgery, 1015 Chestnut Street, 
Philadelphia, PA 19107, United States.
FULL RECORD ENTRY DATE
  1995-11-23
SOURCE
  Spine (1995) 20:22 (2449-2453). Date of Publication: 1995
VOLUME
  20
ISSUE
  22
FIRST PAGE
  2449
LAST PAGE
  2453
DATE OF PUBLICATION
  1995
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Study Design. This study retrospectively reviewed the outcomes of 11 
patients treated for a cervical spine injury with a tracheostomy placed 
before anterior cervical spine surgery. Objectives. The primary goal was to 
show that anterior cervical spine surgery in the setting of spinal cord 
injury is a viable option in patients with previous tracheostomy. Summary of 
Background Data. Respiratory failure after cervical cord injury commonly 
requires tracheostomy, possibly increasing the risk of soft tissue or bony 
infection in patients at high risk for morbidity after surgery. Although 
numerous studies have explored the risk of infection after tracheostomy or 
anterior cervical spine surgery, no study has been performed to explore the 
risk of infection in patients with previous tracheostomy at the time of 
anterior cervical spine surgery. Methods. A retrospective review of the 
clinical data of 1800 spinal cord injury patients seen from 1979 to the 
present at the Regional Spinal Cord Injury Center of the Delaware Valley of 
Thomas Jefferson University with affiliated institutions of Thomas Jefferson 
University Hospital and Magee Rehabilitation Hospital was performed. Eleven 
patients were found who had existing tracheostomy at the time of anterior 
cervical spine surgery. Clinical follow-up period averaged 28 months with a 
range of 6-51 months, and radiographic analysis averaged 7 months with a 
range of 1-51 months. Autogenous lilac crest graft was used in all patients, 
consisting of an intervertebral graft after a discectomy or a strut graft 
after a complete corpectomy. Anterior instrumentation was used in more than 
50% of the patients. Results. After all patient interviews and review of all 
radiographs for evidence of infection, no patient was noted to have evidence 
of a cervical soft tissue or bony infection after surgery. The tracheostomy 
complications were minor and resolved quickly. Conclusions. The authors 
concluded that in patients with cervical cord damage resulting from 
nonpenetrating trauma, tracheostomy was not found to increase the risk of 
infection in subsequent anterior cervical surgery. Careful preparation of 
the skin and placement of the second surgical incision lateral to the 
tracheostomy site is recommended. Anterior cervical spine surgery remains a 
viable treatment option in this severely injured patient population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  infection (complication, epidemiology); spinal cord infection; spine fusion; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; bone graft; cervical spine; clinical article; discectomy; high risk population; human; infection risk; priority journal; respiratory failure (complication); risk assessment; spinal cord injury; spine surgery; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1995338096
MEDLINE PMID
  8578397 (http://www.ncbi.nlm.nih.gov/pubmed/8578397)
PUI
  L25331330
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:&atitle=Occurrence+of+infection+in+anterior+cervical+fusion+for+spinal+cord+injury+after+tracheostomy&stitle=SPINE&title=Spine&volume=20&issue=22&spage=2449&epage=2453&aulast=Northrup&aufirst=B.E.&auinit=B.E.&aufull=Northrup+B.E.&coden=SPIND&isbn=&pages=2449-2453&date=1995&auinit1=B&auinitm=E
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 998
TITLE
  Transoral anterior decompression and fusion of chronic irreducible 
atlantoaxial dislocation with spinal cord compression
AUTHOR NAMES
  Subin B.; Liu J.-F.; Marshall G.J.; Huang H.-Y.; Ou J.-H.; Xu G.-Z.
AUTHOR ADDRESSES
  (Subin B.; Liu J.-F.; Marshall G.J.; Huang H.-Y.; Ou J.-H.; Xu G.-Z.) 
Division of Surgical Research, Childrens Hospital Los Angeles, 4650 Sunset 
Blvd. 35, Los Angeles, CA 90027, United States.
CORRESPONDENCE ADDRESS
  B. Subin, Division of Surgical Research, Childrens Hospital Los Angeles, 
4650 Sunset Blvd. 35, Los Angeles, CA 90027, United States.
FULL RECORD ENTRY DATE
  1995-06-26
SOURCE
  Spine (1995) 20:11 (1233-1240). Date of Publication: 1995
VOLUME
  20
ISSUE
  11
FIRST PAGE
  1233
LAST PAGE
  1240
DATE OF PUBLICATION
  1995
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Study Design. In this study, 10 patients with chronic irreducible 
atlantoaxial dislocation were treated by transoral anterior decompression 
and fusion. Objectives. To examine the benefits of the transoral approach, 
the patients treated with this procedure were compared with the historical 
control subjects after 2 years of follow-up. Summary and Background Data. 
Chronic irreducible atlantoaxial dislocation with cord compression is 
difficult to treat because the cord is compressed posteriorly by the 
posterior arch of the atlas as well as anteriorly by the posterior-superior 
portion of the axial body and nonunited dens. Its irreducibility, as a 
result of the bony scarring between the dens and the anterior body of the 
axis, and the locking of the lateral joints of C1-C2, makes reduction more 
complex. Posterior surgical approaches have been associated with high 
morbidity and mortality. Methods. Ten patients were diagnosed and followed 
up by clinical symptoms, radiography, pantopaque myelography, and computed 
tomography. They were treated surgically by transoral decompression and 
fusion. During the surgery the nonunited dens as well as callus, 
granulation, and scar tissue were removed; the cartilage of the articular 
surfaces of the atlantoaxial joint was excised. Postoperative treatment 
included skull-cervical biaxial traction, tracheostomy care, nasal feeding, 
and Minerva cast. Results. The 2- to 6-year follow-up showed that four out 
of 10 patients recovered completely and returned to work, three recovered to 
a great degree and ambulated, two partially recovered, and one recovered 
poorly. Conclusion. Transoral decompression and fusion offered satisfactory 
results in a series of patients with chronic irreducible atlantoaxial 
dislocation. None of the patients showed serious complications of stability, 
even though only one had a secondary posterior fusion. Therefore, anterior 
decompression associated with subtotal obliteration of the atlantoaxial 
joints without bone grafts is a feasible therapy for irreducible 
atlantoaxial dislocation using a multifunctional bed and biaxial traction.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anterior spine fusion; atlantoaxial dislocation (surgery); odontoid process fracture (surgery); spinal cord compression (complication, surgery); spinal cord decompression; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; chronic disease; clinical article; controlled study; female; hospital bed; human; intravenous drug administration; male; postoperative care; priority journal; spine stabilization; spine surgery; surgical approach; traction therapy; treatment outcome; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1995181996
MEDLINE PMID
  7660230 (http://www.ncbi.nlm.nih.gov/pubmed/7660230)
PUI
  L25168508
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:&atitle=Transoral+anterior+decompression+and+fusion+of+chronic+irreducible+atlantoaxial+dislocation+with+spinal+cord+compression&stitle=SPINE&title=Spine&volume=20&issue=11&spage=1233&epage=1240&aulast=Subin&aufirst=B.&auinit=B.&aufull=Subin+B.&coden=SPIND&isbn=&pages=1233-1240&date=1995&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 999
TITLE
  Respiratory muscle aids for the prevention of pulmonary morbidity and 
mortality
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Dept. of Physical Medicine/Rehab., University Hospital, 150 
Bergen Street, Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Dept. of Physical Medicine/Rehab., University Hospital, 150 
Bergen Street, Newark, NJ 07103, United States.
FULL RECORD ENTRY DATE
  1995-05-30
SOURCE
  Seminars in Neurology (1995) 15:1 (72-83). Date of Publication: 1995
VOLUME
  15
ISSUE
  1
FIRST PAGE
  72
LAST PAGE
  83
DATE OF PUBLICATION
  1995
ISSN
  0271-8235
BOOK PUBLISHER
  Thieme Medical Publishers, Inc., 333 7th Avenue, New York, United States.
ABSTRACT
  The great majority of individuals with ventilatory failure due to paralytic 
syndromes can be managed entirely by noninvasive inspiratory and expiratory 
muscle aids. When the equipment is properly used, individuals may eventually 
become dependent on noninvasive IPPV 24 hours a day without ever being 
hospitalized, intubated, tracheostomized, or bronchoscoped. The use of 
noninvasive respiratory muscle aids eliminates the need for 'crisis' 
decision making about whether or not to 'go on a respirator. Use of 
respiratory muscle aids by ALS patients familiarizes them with ventilator 
dependency before any decision about tracheostomy needs to be made. These 
methods enhance quality of life in many ways, including permitting the use 
of GPB for security in the event of ventilator failure. They can also 
drastically decrease cost and optimize psychosocial functioning. These 
techniques should become part of the therapeutic armamentarium of every 
physician who treats patients with generalized neuromuscular disorders who 
have the potential to develop ventilatory insufficiency, mucus plugging, or 
both.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  amyotrophic lateral sclerosis (rehabilitation); Duchenne muscular dystrophy (rehabilitation); neuromuscular disease (rehabilitation); respiratory failure (complication, prevention, therapy); 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; breathing muscle; coughing; endotracheal intubation; extubation; feedback system; human; intermittent positive pressure ventilation; lung function test; lung ventilation; multiple sclerosis (rehabilitation); muscle weakness (complication, therapy); oximetry; poliomyelitis (rehabilitation); priority journal; review; spinal cord injury (rehabilitation); spine malformation (complication); tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1995156369
MEDLINE PMID
  7638462 (http://www.ncbi.nlm.nih.gov/pubmed/7638462)
PUI
  L25154770
DOI
  10.1055/s-2008-1041010
FULL TEXT LINK
  http://dx.doi.org/10.1055/s-2008-1041010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02718235&id=doi:10.1055%2Fs-2008-1041010&atitle=Respiratory+muscle+aids+for+the+prevention+of+pulmonary+morbidity+and+mortality&stitle=SEMIN.+NEUROL.&title=Seminars+in+Neurology&volume=15&issue=1&spage=72&epage=83&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=SEMNE&isbn=&pages=72-83&date=1995&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1000
TITLE
  Effectiveness of home ventilation of young children and infants
ORIGINAL (NON-ENGLISH) TITLE
  Effektivität der Heimbeatmung bei Kleinkindern und Säuglingen.
AUTHOR NAMES
  Wollinsky K.H.; Mindé A.; Schreiber H.; Kluger P.; Mehrkens H.H.
AUTHOR ADDRESSES
  (Wollinsky K.H.; Mindé A.; Schreiber H.; Kluger P.; Mehrkens H.H.) 
Abteilungen Anästhesiologie/Intensivmedizin, Universität Ulm.
CORRESPONDENCE ADDRESS
  K.H. Wollinsky, Abteilungen Anästhesiologie/Intensivmedizin, Universität 
Ulm.
FULL RECORD ENTRY DATE
  1995-08-21
SOURCE
  Medizinische Klinik (Munich, Germany : 1983) (1995) 90:1 Suppl 1 (57-59). 
Date of Publication: Apr 1995
VOLUME
  90
ISSUE
  1 Suppl 1
FIRST PAGE
  57
LAST PAGE
  59
DATE OF PUBLICATION
  Apr 1995
ISSN
  0723-5003
ABSTRACT
  BACKGROUND: The home care ventilation of patients with chronic respiratory 
insufficiency is a well-established method. In treating infants and newborns 
a lot of problems arise that deal with indication, prognosis and management. 
PATIENTS AND METHODS: We investigated 7 newborns and infants with chronic 
respiratory insufficiency after cervical spine trauma causing "pentaplegia" 
or due to inherited neuromuscular disorders (spinal muscular atrophy, 
myopathy) during homecare ventilation. RESULTS AND DISCUSSION: In contrast 
to experience with adults the management of the children with "pentaplegia" 
was relatively harmless. All were tracheostomized primarily, but 1 
tracheostomy could be closed, because the patient finally achieved to be 
ventilated only during night-time in the iron lung. The 3 children with 
neuromuscular diseases were ventilated noninvasively by specially fitted 
nasal masks. Despite coming to the frontiers of feasibility, and taking into 
account the psychological stress for patients, relatives, doctors and 
nurses, satisfactory results were obtained.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  home care; mask; neonatal respiratory distress syndrome (etiology, therapy); positive end expiratory pressure; respiratory failure (etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; devices; disability; equipment design; female; human; infant; male; newborn; preschool child; 
LANGUAGE OF ARTICLE
  German
MEDLINE PMID
  7616925 (http://www.ncbi.nlm.nih.gov/pubmed/7616925)
PUI
  L125088947
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07235003&id=doi:&atitle=Effectiveness+of+home+ventilation+of+young+children+and+infants&stitle=Med.+Klin.+%28Munich%29&title=Medizinische+Klinik+%28Munich%2C+Germany+%3A+1983%29&volume=90&issue=1+Suppl+1&spage=57&epage=59&aulast=Wollinsky&aufirst=K.H.&auinit=K.H.&aufull=Wollinsky+K.H.&coden=&isbn=&pages=57-59&date=1995&auinit1=K&auinitm=H
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1001
TITLE
  Lateral tracheostomy in patients with cervical spinal cord injury
AUTHOR NAMES
  Tran N.V.; Vernick J.; Cotler J.M.; Rabinovici R.
AUTHOR ADDRESSES
  (Tran N.V.; Vernick J.; Cotler J.M.; Rabinovici R.) Department of Surgery, 
Jefferson Medical College, 1025 Walnut Street, Philadelphia, PA 19107-5083, 
United States.
CORRESPONDENCE ADDRESS
  R. Rabinovici, Department of Surgery, Jefferson Medical College, 1025 Walnut 
Street, Philadelphia, PA 19107-5083, United States.
FULL RECORD ENTRY DATE
  1995-03-29
SOURCE
  British Journal of Surgery (1995) 82:3 (412-413). Date of Publication: 1995
VOLUME
  82
ISSUE
  3
FIRST PAGE
  412
LAST PAGE
  413
DATE OF PUBLICATION
  1995
ISSN
  0007-1323
BOOK PUBLISHER
  John Wiley and Sons Ltd, Southern Gate, Chichester, West Sussex, United 
Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; clinical article; human; priority journal; surgical technique; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1995078374
MEDLINE PMID
  7796029 (http://www.ncbi.nlm.nih.gov/pubmed/7796029)
PUI
  L25076975
DOI
  10.1002/bjs.1800820345
FULL TEXT LINK
  http://dx.doi.org/10.1002/bjs.1800820345
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00071323&id=doi:10.1002%2Fbjs.1800820345&atitle=Lateral+tracheostomy+in+patients+with+cervical+spinal+cord+injury&stitle=BR.+J.+SURG.&title=British+Journal+of+Surgery&volume=82&issue=3&spage=412&epage=413&aulast=Tran&aufirst=N.V.&auinit=N.V.&aufull=Tran+N.V.&coden=BJSUA&isbn=&pages=412-413&date=1995&auinit1=N&auinitm=V
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1002
TITLE
  Noninvasive long-term ventilatory support for individuals with spinal 
muscular atrophy and functional bulbar musculature
AUTHOR NAMES
  Bach J.R.; Wang T.-G.
AUTHOR ADDRESSES
  (Bach J.R.; Wang T.-G.) Dept. of Physical Medicine/Rehab., University 
Hospital B-239, 150 Bergen Street, Newark, NJ, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Dept. of Physical Medicine/Rehab., University Hospital B-239, 150 
Bergen Street, Newark, NJ, United States.
FULL RECORD ENTRY DATE
  1995-03-26
SOURCE
  Archives of Physical Medicine and Rehabilitation (1995) 76:3 (213-217). Date 
of Publication: 1995
VOLUME
  76
ISSUE
  3
FIRST PAGE
  213
LAST PAGE
  217
DATE OF PUBLICATION
  1995
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Ten individuals with spinal muscular atrophy (SMA) and chronic ventilatory 
insufficiency were trained in the use of assisted coughing techniques and 
received intermittent positive pressure ventilation (IPPV) via oral and/or 
nasal interfaces for a mean of 5.3 (range = 1 to 17) years. During this time 
they had significantly fewer respiratory complications than before 
introduction of noninvasive respiratory muscle aids despite the fact that 6 
of the 10 went on to require more than 20 hours per day of ventilator use 
with less than 2 hours of ventilator-free breathing time (VFBT). All except 
two noninvasive IPPV users had vital capacities (VCs) less than 13% of 
predicted normal. They could, however, communicate verbally and take 
nutrition by mouth. All of the patients remained in the community. Five 
patients were gainfully employed and four were in school. We conclude that 
noninvasive respiratory muscle aids including noninvasive IPPV and assisted 
coughing techniques are effective and practical alternatives to tracheostomy 
for SMA patients with ventilatory failure but functional bulbar musculature.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  assisted ventilation; respiratory failure (complication, therapy); spinal muscular atrophy (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; breathing muscle; child; chronic disease; clinical article; clinical trial; human; intermittent positive pressure ventilation; long term care; neurologic disease (rehabilitation); oropharynx; vital capacity; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1995085828
MEDLINE PMID
  7717810 (http://www.ncbi.nlm.nih.gov/pubmed/7717810)
PUI
  L25084426
DOI
  10.1016/S0003-9993(95)80603-2
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-9993(95)80603-2
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:10.1016%2FS0003-9993%2895%2980603-2&atitle=Noninvasive+long-term+ventilatory+support+for+individuals+with+spinal+muscular+atrophy+and+functional+bulbar+musculature&stitle=ARCH.+PHYS.+MED.+REHABIL.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=76&issue=3&spage=213&epage=217&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=APMHA&isbn=&pages=213-217&date=1995&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1003
TITLE
  Ethical considerations in the management of individuals with severe 
neuromuscular disorders
AUTHOR NAMES
  Bach J.R.; Barnett V.
AUTHOR ADDRESSES
  (Bach J.R.; Barnett V.) Physical Med./Rehabilitation Dept., University 
Hospital, 150 Bergen St., Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Physical Med./Rehabilitation Dept., University Hospital, 150 
Bergen St., Newark, NJ 07103, United States.
FULL RECORD ENTRY DATE
  1995-03-17
SOURCE
  American Journal of Physical Medicine and Rehabilitation (1995) 74:1 SUPPL. 
(S34-S40). Date of Publication: 1995
VOLUME
  74
ISSUE
  1 SUPPL.
DATE OF PUBLICATION
  1995
ISSN
  0894-9115
ABSTRACT
  There have been many recent advances in improving the quality of life and 
prolonging life for individuals with advanced neuromuscular disease. These 
include the use of physical medicine techniques to balance extremity muscle 
strength and improve range of motion and noninvasive techniques to provide 
inspiratory and expiratory muscle assistance to prolong life without resort 
to tracheostomy. Such advances help eliminate the 'crisis' decision making 
about 'going on a respirator' and sophisticated assistive equipment and 
robotic aids. Physicians and society in general use quality of life issues 
inappropriately derived by questioning physically able individuals to 
justify withholding or implementing life-sustaining therapeutic 
interventions for these individuals. Informed decisions about ethically and 
financially complex matters such as long-term ventilator use should be made 
by examining the life satisfaction of competent individuals who have already 
chosen these options. The great majority of severely disabled 
ventilator-assisted individuals with neuromuscular disease are satisfied 
with their lives despite the inability to achieve many of the 'usual' goals 
associated with quality of life in the physically able population. Their 
principle life satisfaction derives from social relationships, the 
reorganization of goals and from their immediate environment. Although the 
Americans with Disabilities Act is seen as an important step to prevent 
discrimination against disabled individuals, it does little or nothing for 
the self-directed disabled individual who is not informed by his/her 
physicians regarding potentially vital therapeutic options nor does it help 
those who are warehoused in institutions because of lack of a national 
personal assistance services policy. This is ironic because the provision of 
personal assistance services for the home care of ventilator-assisted 
individuals can greatly reduce cost as well as enhance quality of life. The 
institutional control of chronic care, whether in an institution itself, or 
in the community with personal assistance services managed by nursing 
organizations rather than by the self-directed client himself, 
impersonalizes and dehumanizes care in the name of safety. It reduces the 
client's sense of personal control and self-efficacy and suggests inadequacy 
in coping except in the most restrictive environment. Physical medicine and 
rehabilitation specialists who train their patients in how to manage and 
take responsibility for their care need to play a more active role in 
advocating for the procurement of the services needed to permit them to 
return to the community.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; medical ethics; neuromuscular disease (rehabilitation); rehabilitation medicine; respiratory failure (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  cost control; disability; Duchenne muscular dystrophy (rehabilitation); health care cost; life satisfaction; patient right; poliomyelitis (rehabilitation); quality of life; review; spinal cord injury (rehabilitation); 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
  Health Policy, Economics and Management (36)
  Forensic Science Abstracts (49)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1995075879
PUI
  L25074490
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08949115&id=doi:&atitle=Ethical+considerations+in+the+management+of+individuals+with+severe+neuromuscular+disorders&stitle=AM.+J.+PHYS.+MED.+REHABIL.&title=American+Journal+of+Physical+Medicine+and+Rehabilitation&volume=74&issue=1+SUPPL.&spage=&epage=&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=AJPRE&isbn=&pages=-&date=1995&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1004
TITLE
  Respiratory dysfunction associated with traumatic injury to the central 
nervous system
AUTHOR NAMES
  Slack R.S.; Shucart W.
AUTHOR ADDRESSES
  (Slack R.S.; Shucart W.) Natividad Medical Center, 1330 Natividad Road, 
Salinas, CA 93906, United States.
CORRESPONDENCE ADDRESS
  R.S. Slack, Natividad Medical Center, 1330 Natividad Road, Salinas, CA 
93906, United States.
FULL RECORD ENTRY DATE
  1994-12-28
SOURCE
  Clinics in Chest Medicine (1994) 15:4 (739-749). Date of Publication: 1994
VOLUME
  15
ISSUE
  4
FIRST PAGE
  739
LAST PAGE
  749
DATE OF PUBLICATION
  1994
ISSN
  0272-5231
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  Pulmonary dysfunction is a common complication of head trauma and spinal 
cord injury. Abnormal breathing patterns reflect the influence of altered 
neural integration. Early arterial hypoxemia can result from ventilation- 
perfusion mismatching, microatelectasis, aspiration, fat embolism, or the 
development of the adult respiratory distress syndrome. Significant changes 
in lung volumes, ventilation, and gas exchange can occur in spinal cord 
injury as a result of the loss of diaphramatic or intercostal muscle 
function. Recruitment of accessory respiratory muscles plays an important 
role in stabilizing the rib cage and improving expiratory function. Strength 
training improves expiratory muscle function in quadriplegics and should be 
continued indefinitely. Most importantly, survival of patients with CNS 
injuries improves with meticulous and vigorous pulmonary hygiene. The 
pulmonary hygiene program should include regular changes in the patient's 
position, assisted coughing and deep breathing exercises, incentive 
spirometer, bronchodilators, fiberoptic bronchoscopy when indicated, and 
frequent monitoring of pulmonary mechanics. Long-term survival of the 
patient with head trauma or spinal cord injury is correlated to successful 
weaning from mechanical ventilation. Various forms of mechanical ventilator 
support can be adopted for the patient's ventilatory needs and many patients 
will achieve some degree of freedom from mechanical ventilation. Newer 
ventilatory assist devices that do not require tracheostomy should be 
considered.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; respiratory failure (complication, etiology, therapy); spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  bacterial pneumonia (complication); breathing pattern; bronchus secretion; cervical spinal cord injury (therapy); Cheyne Stokes breathing (diagnosis, etiology); endotracheal intubation; human; hyperventilation; hypoxemia (complication); lung edema (complication, etiology); lung embolism (complication); lung mechanics; mucus secretion; patient positioning; positive end expiratory pressure; priority journal; respiration control; review; suction drainage; tracheobronchial toilet; traffic accident; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994377333
MEDLINE PMID
  7867288 (http://www.ncbi.nlm.nih.gov/pubmed/7867288)
PUI
  L24371960
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02725231&id=doi:&atitle=Respiratory+dysfunction+associated+with+traumatic+injury+to+the+central+nervous+system&stitle=CLIN.+CHEST+MED.&title=Clinics+in+Chest+Medicine&volume=15&issue=4&spage=739&epage=749&aulast=Slack&aufirst=R.S.&auinit=R.S.&aufull=Slack+R.S.&coden=CCHMD&isbn=&pages=739-749&date=1994&auinit1=R&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1005
TITLE
  Options for mechanical ventilation in neuromuscular diseases
AUTHOR NAMES
  Unterborn J.N.; Hill N.S.
AUTHOR ADDRESSES
  (Unterborn J.N.; Hill N.S.) Pulmonary/Critical Care Med. Div., Rhode Island 
Hospital, 593 Eddy Street, Providence, RI 02903, United States.
CORRESPONDENCE ADDRESS
  N.S. Hill, Pulmonary/Critical Care Med. Div., Rhode Island Hospital, 593 
Eddy Street, Providence, RI 02903, United States.
FULL RECORD ENTRY DATE
  1994-12-28
SOURCE
  Clinics in Chest Medicine (1994) 15:4 (765-781). Date of Publication: 1994
VOLUME
  15
ISSUE
  4
FIRST PAGE
  765
LAST PAGE
  781
DATE OF PUBLICATION
  1994
ISSN
  0272-5231
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  A variety of mechanical devices may be used to provide assistance when 
ventilation and cough are severely impaired by progressive respiratory 
weakness caused by neuromuscular disease. Traditionally, positive pressure 
ventilation via a tracheostomy has been used, but if upper airway function 
is adequate, a variety of noninvasive devices also may be considered. 
Although positive pressure ventilation is the preferred noninvasive mode for 
assisting ventilation, other modes may be selected depending on patient 
needs, preferences, and physical characteristics.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; neuromuscular disease (therapy); respiratory failure (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  amyotrophic lateral sclerosis (therapy); article; assisted ventilation; breathing mechanics; cerebrovascular accident (therapy); follow up; Guillain Barre syndrome (therapy); human; medical decision making; multiple sclerosis (therapy); muscular dystrophy (therapy); myasthenia gravis (therapy); Parkinson disease (therapy); patient monitoring; positive end expiratory pressure; priority journal; spinal cord injury; ventilator; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994377335
MEDLINE PMID
  7867290 (http://www.ncbi.nlm.nih.gov/pubmed/7867290)
PUI
  L24371962
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02725231&id=doi:&atitle=Options+for+mechanical+ventilation+in+neuromuscular+diseases&stitle=CLIN.+CHEST+MED.&title=Clinics+in+Chest+Medicine&volume=15&issue=4&spage=765&epage=781&aulast=Unterborn&aufirst=J.N.&auinit=J.N.&aufull=Unterborn+J.N.&coden=CCHMD&isbn=&pages=765-781&date=1994&auinit1=J&auinitm=N
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1006
TITLE
  The prevention of spread of methicillin resistant Staphylococcus aureus in a 
spinal injuries centre
AUTHOR NAMES
  Pick F.C.M.; Rose M.; Wang D.; Gardner B.P.; Gillett A.P.
AUTHOR ADDRESSES
  (Pick F.C.M.; Rose M.; Wang D.; Gardner B.P.; Gillett A.P.) Stoke Mandeville 
Hospital, Aylesbury, Bucks HP21 8AL, United Kingdom.
CORRESPONDENCE ADDRESS
  F.C.M. Pick, Stoke Mandeville Hospital, Aylesbury, Bucks HP21 8AL, United 
Kingdom.
FULL RECORD ENTRY DATE
  1994-12-16
SOURCE
  Paraplegia (1994) 32:11 (732-735). Date of Publication: 1994
VOLUME
  32
ISSUE
  11
FIRST PAGE
  732
LAST PAGE
  735
DATE OF PUBLICATION
  1994
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  The National Spinal Injuries Centre (NSIC) is a tertiary referral centre. It 
accepts most of its patients from other hospitals in the UK and overseas. 
The severity of injury, the presence of a tracheostomy, urinary catheter and 
pressure sores predisposes this group of patients to colonisation or 
infection with Methicillin resistant Staphylococcus aureus (MRSA). The NSIC 
uses simple but strict protocols for hygiene, screening for MRSA, and source 
isolation of known or suspected MRSA carriers in single room accommodation 
to control the spread of MRSA in the centre. A retrospective search of 
microbiology and patient records revealed that in 4 years there had been 24 
admissions with MRSA, with a total of 1421 isolation days. There was only 
one outbreak of MRSA. This involved three patients. Hygiene, screening of 
potential MRSA carriers together with single room isolation can limit the 
spread of MRSA.
EMTREE DRUG INDEX TERMS
  meticillin (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  penicillin resistance; spine injury; Staphylococcus infection (complication, drug therapy, prevention); 
EMTREE MEDICAL INDEX TERMS
  article; bladder catheterization; clinical article; decubitus (complication); female; hospital hygiene; human; infection control; length of stay; male; medical record; microbiology; patient referral; priority journal; Staphylococcus aureus; tracheostomy; United Kingdom; 
CAS REGISTRY NUMBERS
  meticillin (132-92-3, 38882-79-0, 61-32-5)
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994370838
MEDLINE PMID
  7885715 (http://www.ncbi.nlm.nih.gov/pubmed/7885715)
PUI
  L24361450
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=The+prevention+of+spread+of+methicillin+resistant+Staphylococcus+aureus+in+a+spinal+injuries+centre&stitle=PARAPLEGIA&title=Paraplegia&volume=32&issue=11&spage=732&epage=735&aulast=Pick&aufirst=F.C.M.&auinit=F.C.M.&aufull=Pick+F.C.M.&coden=PRPLB&isbn=&pages=732-735&date=1994&auinit1=F&auinitm=C.M.
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1007
TITLE
  Mechanical ventilation in acute cervical spinal cord injuries
ORIGINAL (NON-ENGLISH) TITLE
  LA VENTILACION MECANICA EN EL LESIONADO MEDULAR CERVICAL AGUDO
AUTHOR NAMES
  Romero Ganuza J.; La Banda Brusi F.; Garcia Leoni M.E.; Gambarruta de Shore C.; Espinosa Ramirez S.; Cortes Bermejo S.; Mazaira Alvarez J.
AUTHOR ADDRESSES
  (Romero Ganuza J.; La Banda Brusi F.; Garcia Leoni M.E.; Gambarruta de Shore 
C.; Espinosa Ramirez S.; Cortes Bermejo S.; Mazaira Alvarez J.) Unidad de 
Cuidados Intensivos, Hospital Nacional de Paraplejicos, Toledo, Spain.
CORRESPONDENCE ADDRESS
  J. Romero Ganuza, Unidad de Cuidados Intensivos, Hospital Nacional de 
Paraplejicos, Toledo, Spain.
FULL RECORD ENTRY DATE
  1995-01-24
SOURCE
  Medicina Intensiva (1994) 18:9 (465-471). Date of Publication: 1994
VOLUME
  18
ISSUE
  9
FIRST PAGE
  465
LAST PAGE
  471
DATE OF PUBLICATION
  1994
ISSN
  0210-5691
ABSTRACT
  Objective. To analyse respiratory care required by patients with acute 
cervical spinal cord injuries. Methods. We have retrospectively studied all 
the patients admitted to the ICU of the Hospital Nacional de Paraplejicos de 
Toledo with traumatic cervical spinal cord injury during 2.5 years. From the 
whole group, 183 patients required to be transferred to the ICU and 131 
needed mechanical ventilation. Results. Mechanical ventilation lasts a long 
time, and this causes long ICU stays: the higher is the level of the injury, 
the longer is the stay. There is a high rate of respiratory complications 
(71.6%), and tracheostomies (91.6%); and a low mortality (5.5%). 
Conclusions. Every cervical spinal cord injury must be initially admitted to 
the ICU. If mechanical ventilation is required it must be assumed to be 
prolonged and so will be the stay; there is a relation between the level of 
the injury and the necessity of mechanical ventilation. Mode of ventilation 
and weaning must be individualized. Tracheostomy necessity is related to the 
level of the injury. There is a low mortality according to a low APACHE II 
score and a low rate of associated lesions in our series. It is desirable to 
transfer this type of patients to a unit specialized in spinal cord injuries 
when the situation of the patient allows it.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury (rehabilitation, therapy); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; child; female; human; infant; length of stay; major clinical study; male; mortality; newborn; preschool child; quadriplegia (rehabilitation, therapy); respiratory tract disease (complication); retrospective study; school child; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  Spanish, English
EMBASE ACCESSION NUMBER
  1995024793
PUI
  L25023519
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02105691&id=doi:&atitle=Mechanical+ventilation+in+acute+cervical+spinal+cord+injuries&stitle=MED.+INTENSIVA&title=Medicina+Intensiva&volume=18&issue=9&spage=465&epage=471&aulast=Romero+Ganuza&aufirst=J.&auinit=J.&aufull=Romero+Ganuza+J.&coden=MDINE&isbn=&pages=465-471&date=1994&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1008
TITLE
  Tracheostomy ventilation versus diaphragmatic pacemaker ventilation in high 
spinal cord injury
AUTHOR NAMES
  Esclarin A.; Bravo P.; Arroyo O.; Mazaira J.; Garrido H.; Alcaraz M.A.
AUTHOR ADDRESSES
  (Esclarin A.; Bravo P.; Arroyo O.; Mazaira J.; Garrido H.; Alcaraz M.A.) 
Hospital Nacional de Paraplejicos, Finca La Peraleda s-n, Toledo, Spain.
CORRESPONDENCE ADDRESS
  A. Esclarin, Hospital Nacional de Paraplejicos, Finca La Peraleda s-n, 
Toledo, Spain.
FULL RECORD ENTRY DATE
  1994-11-14
SOURCE
  Paraplegia (1994) 32:10 (687-693). Date of Publication: 1994
VOLUME
  32
ISSUE
  10
FIRST PAGE
  687
LAST PAGE
  693
DATE OF PUBLICATION
  1994
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  We have made a retrospective comparative study of patients with spinal cord 
injury, nine with a diaphragmatic pacemaker and 13 with mechanical 
ventilation. Clinical outcome, cost and subjective satisfaction with both 
modalities have been evaluated. The functional status was the same with both 
types of treatment. Proper management of an electric wheelchair and optimal 
phonation were attained, respectively, in 100% and 89% of pacers and in 77% 
and 77% of mechanically ventilated. The rate of hospital discharge and 
satisfaction with the treatment were significantly better for pacers. The 
time devoted to ventilatory assistance and cost were also more favourable in 
this group.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cardiac rhythm management device; spinal cord injury (rehabilitation); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; clinical article; controlled study; cost benefit analysis; female; hospital discharge; human; intermethod comparison; male; patient satisfaction; phonation; priority journal; school child; wheelchair; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994339328
MEDLINE PMID
  7831076 (http://www.ncbi.nlm.nih.gov/pubmed/7831076)
PUI
  L24330375
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Tracheostomy+ventilation+versus+diaphragmatic+pacemaker+ventilation+in+high+spinal+cord+injury&stitle=PARAPLEGIA&title=Paraplegia&volume=32&issue=10&spage=687&epage=693&aulast=Esclarin&aufirst=A.&auinit=A.&aufull=Esclarin+A.&coden=PRPLB&isbn=&pages=687-693&date=1994&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1009
TITLE
  Respiratory complications after cervical spinal cord injury
AUTHOR NAMES
  Lemons V.R.; Wagner Jr. F.C.
AUTHOR ADDRESSES
  (Lemons V.R.; Wagner Jr. F.C.) Department of Neurological Surgery, 
University of California, 2516 Stockton Blvd., Sacramento, CA 95817, United 
States.
CORRESPONDENCE ADDRESS
  V.R. Lemons, Department of Neurological Surgery, University of California, 
2516 Stockton Blvd., Sacramento, CA 95817, United States.
FULL RECORD ENTRY DATE
  1994-11-11
SOURCE
  Spine (1994) 19:20 (2315-2320). Date of Publication: 1994
VOLUME
  19
ISSUE
  20
FIRST PAGE
  2315
LAST PAGE
  2320
DATE OF PUBLICATION
  1994
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Study Design. Sixty-five consecutive cases of acute cervical spinal cord 
injuries were reviewed retrospectively for respiratory complications. 
Objectives. The objectives were to identify factors that may contribute to 
respiratory dysfunction and to evaluate therapeutic measures designed to 
reduce respiratory complications. Summary of Background Data. Respiratory 
complications continue to be a major cause of morbidity and mortality after 
cervical spinal cord injury with a reported incidence from 36 to 83%. 
Methods. Multiple factors were evaluated which could potentially influence 
the incidence or severity of respiratory complications. These included age, 
pre-existing cardiac or pulmonary disease, accompanying major injuries and 
the severity of the spinal cord injury. The effects of various therapeutic 
measures were also assessed including the benefit of rotating beds, early 
fracture stabilization and patient mobilization. Results. Respiratory 
complications occurred in 62% of these patients and were transient in 
nature, variable in severity and duration, strongly associated with the 
severity of spinal cord injury, and only marginally affected by therapeutic 
interventions. Conclusions. The characteristics of respiratory dysfunction 
following cervical spinal cord injury correspond to those of spinal shock.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spinal cord injury (etiology); respiratory tract disease (complication); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; atelectasis (complication); conference paper; fiberoptic bronchoscopy; human; incidence; intubation; lung embolism (complication); major clinical study; pneumonia (complication); priority journal; respiratory failure (complication); retrospective study; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994332870
MEDLINE PMID
  7846577 (http://www.ncbi.nlm.nih.gov/pubmed/7846577)
PUI
  L24329155
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:&atitle=Respiratory+complications+after+cervical+spinal+cord+injury&stitle=SPINE&title=Spine&volume=19&issue=20&spage=2315&epage=2320&aulast=Lemons&aufirst=V.R.&auinit=V.R.&aufull=Lemons+V.R.&coden=SPIND&isbn=&pages=2315-2320&date=1994&auinit1=V&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1010
TITLE
  Tuberculosis of the cervical spine
AUTHOR NAMES
  Bahadori R.S.; Arjmand E.M.; Goldberg A.N.
AUTHOR ADDRESSES
  (Bahadori R.S.; Arjmand E.M.; Goldberg A.N.) Department of Otolaryngology, 
Washington Univ. School of Medicine, Box 8115, 517 South Euclid Ave., St. 
Louis, MO 63110, United States.
CORRESPONDENCE ADDRESS
  R.S. Bahadori, Department of Otolaryngology, Washington Univ. School of 
Medicine, Box 8115, 517 South Euclid Ave., St. Louis, MO 63110, United 
States.
FULL RECORD ENTRY DATE
  1994-07-19
SOURCE
  Otolaryngology - Head and Neck Surgery (1994) 110:6 (595-597). Date of 
Publication: 1994
VOLUME
  110
ISSUE
  6
FIRST PAGE
  595
LAST PAGE
  597
DATE OF PUBLICATION
  1994
ISSN
  0194-5998
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ceftriaxone (drug combination, drug therapy); clindamycin (drug combination, drug therapy); isoniazid (drug combination, drug therapy, pharmacology); pyrazinamide (drug combination, drug therapy, pharmacology); rifampicin (drug combination, drug therapy, pharmacology); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine dislocation (surgery); retropharyngeal abscess (drug therapy, surgery); tuberculous spondylitis (drug therapy, etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; article; bone graft; case report; human; human tissue; lymphadenopathy (complication); male; Mycobacterium tuberculosis; tracheotomy; traction therapy; trismus (complication); 
CAS REGISTRY NUMBERS
  ceftriaxone (73384-59-5, 74578-69-1)
  clindamycin (18323-44-9)
  isoniazid (54-85-3, 62229-51-0, 65979-32-0)
  pyrazinamide (98-96-4)
  rifampicin (13292-46-1)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1994209862
MEDLINE PMID
  8208580 (http://www.ncbi.nlm.nih.gov/pubmed/8208580)
PUI
  L24204264
DOI
  10.1177/019459989411000622
FULL TEXT LINK
  http://dx.doi.org/10.1177/019459989411000622
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01945998&id=doi:10.1177%2F019459989411000622&atitle=Tuberculosis+of+the+cervical+spine&stitle=OTOLARYNGOL.+HEAD+NECK+SURG.&title=Otolaryngology+-+Head+and+Neck+Surgery&volume=110&issue=6&spage=595&epage=597&aulast=Bahadori&aufirst=R.S.&auinit=R.S.&aufull=Bahadori+R.S.&coden=OTOLD&isbn=&pages=595-597&date=1994&auinit1=R&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1011
TITLE
  Survival of individuals with spinal muscular atrophy on ventilatory support
AUTHOR NAMES
  Wang T.-G.; Bach J.R.; Avilla C.; Alba A.S.; Yang G.-F.W.
AUTHOR ADDRESSES
  (Wang T.-G.; Bach J.R.; Avilla C.; Alba A.S.; Yang G.-F.W.) Physical 
Med./Rehabilitation Dept., University Hospital B-239, 150 Bergen St., 
Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Physical Med./Rehabilitation Dept., University Hospital B-239, 
150 Bergen St., Newark, NJ 07103, United States.
FULL RECORD ENTRY DATE
  1994-07-10
SOURCE
  American Journal of Physical Medicine and Rehabilitation (1994) 73:3 
(207-211). Date of Publication: 1994
VOLUME
  73
ISSUE
  3
FIRST PAGE
  207
LAST PAGE
  211
DATE OF PUBLICATION
  1994
ISSN
  0894-9115
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  Six ventilator-assisted individuals (VAIs) with spinal muscular atrophy 
(SMA) are described. All six survived by using intermittent positive 
pressure ventilation via an indwelling tracheostomy for a mean of 11.7 ± 
17.7 yr despite frequent episodes of mucus plugging and pneumonia. Four of 
the VAIs also received all nutrition via indwelling gastrostomy tubes 
because of severe bulbar muscle weakness. Four VAIs used tracheostomy 
intermittent positive pressure ventilation with their tracheostomy cuffs 
deflated and could communicate verbally. Five of the six VAIs remained 
institutionalized from the onset of ventilatory use. Two SMA VAIs survived 
for 15 and 4 yr, respectively, despite need for ventilatory support since 
early infancy. All four SMA VAIs who could communicate remained socially 
active and one, gainfully employed. We conclude that for patients with 
advanced SMA markedly prolonged survival is possible with ventilatory 
assistance despite severe respiratory and bulbar muscle dysfunction.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  positive end expiratory pressure; respiratory failure (complication, therapy); spinal muscular atrophy (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; artificial ventilation; child; chronic disease; clinical article; clinical trial; female; human; interpersonal communication; male; neuromuscular disease (rehabilitation); pneumonia (complication); social adaptation; survival time; tracheostomy; vital capacity; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994205219
MEDLINE PMID
  8198777 (http://www.ncbi.nlm.nih.gov/pubmed/8198777)
PUI
  L24192986
DOI
  10.1097/00002060-199406000-00010
FULL TEXT LINK
  http://dx.doi.org/10.1097/00002060-199406000-00010
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08949115&id=doi:10.1097%2F00002060-199406000-00010&atitle=Survival+of+individuals+with+spinal+muscular+atrophy+on+ventilatory+support&stitle=AM.+J.+PHYS.+MED.+REHABIL.&title=American+Journal+of+Physical+Medicine+and+Rehabilitation&volume=73&issue=3&spage=207&epage=211&aulast=Wang&aufirst=T.-G.&auinit=T.-G.&aufull=Wang+T.-G.&coden=AJPRE&isbn=&pages=207-211&date=1994&auinit1=T&auinitm=-G
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1012
TITLE
  The tracheostomy tube.
AUTHOR NAMES
  Kirschner K.L.; Smith J.; Donnelley S.
AUTHOR ADDRESSES
  (Kirschner K.L.; Smith J.; Donnelley S.) Rehabilitation Institute of 
Chicago.
CORRESPONDENCE ADDRESS
  K.L. Kirschner, Rehabilitation Institute of Chicago.
FULL RECORD ENTRY DATE
  1994-08-10
SOURCE
  The Hastings Center report (1994) 24:2 (26; discussion 26-27). Date of 
Publication: 1994 Mar-Apr
VOLUME
  24
ISSUE
  2
DATE OF PUBLICATION
  1994 Mar-Apr
ISSN
  0093-0334
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  living will; respiratory failure (etiology, surgery); spinal cord injury (complication, rehabilitation); tracheostomy; treatment refusal; 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; case report; decision making; doctor patient relationship; emergency; human; male; medical staff; professional-patient relationship; psychological aspect; treatment withdrawal; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  8026934 (http://www.ncbi.nlm.nih.gov/pubmed/8026934)
PUI
  L24914128
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00930334&id=doi:&atitle=The+tracheostomy+tube.&stitle=Hastings+Cent+Rep&title=The+Hastings+Center+report&volume=24&issue=2&spage=&epage=&aulast=Kirschner&aufirst=K.L.&auinit=K.L.&aufull=Kirschner+K.L.&coden=&isbn=&pages=-&date=1994&auinit1=K&auinitm=L
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1013
TITLE
  Problems of long term hospitalised spinal cord injury patients in university 
hospitals
AUTHOR NAMES
  Arima T.; Noguchi T.; Mochida J.; Toh E.; Konagai A.; Nishimura K.
AUTHOR ADDRESSES
  (Arima T.; Noguchi T.; Mochida J.; Toh E.; Konagai A.; Nishimura K.) 
Department of Orthopaedics, Hakone National Hospital, Kanagawa, Japan.
CORRESPONDENCE ADDRESS
  T. Arima, Department of Orthopaedics, Hakone National Hospital, Kanagawa, 
Japan.
FULL RECORD ENTRY DATE
  1994-02-04
SOURCE
  Paraplegia (1994) 32:1 (19-24). Date of Publication: 1994
VOLUME
  32
ISSUE
  1
FIRST PAGE
  19
LAST PAGE
  24
DATE OF PUBLICATION
  1994
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Of the 215 cervical spinal cord injury (CSCI) patients treated in Tokai 
University Hospital over the last 17 years, 42 who were hospitalised for 
more than 90 days were selected as the subjects for this survey. They were 
divided into two groups: group A: patients hospitalised for 180 days or 
more; and group B: patients hospitalised for more than 90 but less than 180 
days. The aspects surveyed were: the number of days of hospitalisation, type 
of injury, level of spinal cord injury, extent of spinal cord paralysis, 
assessment based on Frankel's classifications, whether a tracheotomy was 
performed or not, surgical treatment, complications, and the clinical course 
after discharge. The most common injury for the 13 patients in group A 
(average stay 281 days) was a fracture-dislocation, followed next by those 
with a burst fracture. The majority of the 28 patients in group B (average 
stay was 117 days) had a central type of spinal cord injury. Characteristics 
observed in group A in particular were: higher segment injuries to the 
cervical spinal cord, complete paralysis, respiratory complications such as 
pneumonia, tracheotomy, or a waiting time of at least 6 months before 
discharge, in cases where a transfer to a rehabilitation hospital was 
possible. The major problems of treating CSCI patients in university 
hospitals are that severe cases, which are concentrated in university 
hospitals, are forced to occupy private rooms for long term treatment, and 
there is a difficulty in transferring these patients to rehabilitation 
hospitals. The following measures are desirable to improve the situation: 
construction of facilities specialising in the treatment of spinal cord 
injuries, and other assertive measures to be taken at national and 
prefectural levels.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hospitalization; long term care; spinal cord injury (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; article; cervical spinal cord injury (rehabilitation); cervical spine dislocation; clinical article; female; hospital discharge; human; Japan; male; pneumonia (complication); priority journal; tracheotomy; university hospital; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994041505
MEDLINE PMID
  8015831 (http://www.ncbi.nlm.nih.gov/pubmed/8015831)
PUI
  L24032722
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Problems+of+long+term+hospitalised+spinal+cord+injury+patients+in+university+hospitals&stitle=PARAPLEGIA&title=Paraplegia&volume=32&issue=1&spage=19&epage=24&aulast=Arima&aufirst=T.&auinit=T.&aufull=Arima+T.&coden=PRPLB&isbn=&pages=19-24&date=1994&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1014
TITLE
  Airway control in trauma patients with cervical spine fractures.
AUTHOR NAMES
  Lord S.A.; Boswell W.C.; Williams J.S.; Odom J.W.; Boyd C.R.
AUTHOR ADDRESSES
  (Lord S.A.; Boswell W.C.; Williams J.S.; Odom J.W.; Boyd C.R.) Department of 
Surgical Education, Memorial Medical Center, Savannah, Georgia 31403-3089, 
USA.
CORRESPONDENCE ADDRESS
  S.A. Lord, Department of Surgical Education, Memorial Medical Center, 
Savannah, Georgia 31403-3089, USA.
FULL RECORD ENTRY DATE
  1995-12-01
SOURCE
  Prehospital and disaster medicine : the official journal of the National 
Association of EMS Physicians and the World Association for Emergency and 
Disaster Medicine in association with the Acute Care Foundation (1994) 9:1 
(44-49). Date of Publication: 1994 Jan-Mar
VOLUME
  9
ISSUE
  1
FIRST PAGE
  44
LAST PAGE
  49
DATE OF PUBLICATION
  1994 Jan-Mar
ISSN
  1049-023X
ABSTRACT
  INTRODUCTION: Proper airway control in trauma patients who have sustained 
cervical spine fracture remains controversial. PURPOSE: This study was 
undertaken to survey the preferred methods of airway management in cervical 
spine fracture (CSF) patients, to evaluate the experience of handling such 
patients at a level-I trauma center, and to contrast the findings with 
recommendations of the American College of Surgeons Committee on Trauma. 
HYPOTHESIS: The methods used for control of the airway in patients with 
fractures of their cervical spine support the recommendation of the American 
College of Surgeons (ACS) Committee on Trauma. METHODS: The study consisted 
of two parts: 1) a survey; and 2) a retrospective study. Survey 
questionnaires were sent to 199 members of the Eastern Association for the 
Surgery of Trauma and to 161 anesthesiology training programs throughout the 
United States. Three resuscitation scenarios were posed: 1) Elective 
airway--CSF--breathing spontaneously, stable vital signs; 2) Urgent 
airway--CSF--breathing spontaneously, unstable vital signs; and 3) Emergent 
airway--CSF--apneic, unstable. In addition, a three-year retrospective study 
was conducted at a level-I trauma center to determine the method of airway 
control in patients with cervical spine fractures. RESULTS: Responses to the 
questionnaires were received from 101 trauma surgeons (TS) and 58 
anesthesiologists (ANESTH). Respondents indicated their preference of airway 
methods: Elective airway: Nasotracheal intubation: TS 69%, ANESTH 53%. 
Orotracheal intubation: TS and ANESTH 27%. Surgical airway: TS 4%. 
Intubation with fiberoptic bronchoscope (FOB): ANESTH 20%. Urgent airway: 
Nasotracheal intubation: TS 48%, ANESTH 38%. Orotracheal intubation: TS 47%, 
ANESTH 45%. Surgical airway: TS 4%. FOB: ANESTH 16%. Emergent airway: 
Orotracheal intubation: TS 81%, ANESTH 78%. Surgical Airway: TS 19%, ANESTH 
7%. FOB: ANESTH 15%. The retrospective review at the trauma center indicated 
that 102 patients with CSF were admitted; 62 required intubation: four (6%) 
on the scene, seven (11%) en route, five (8%) in the emergency department, 
42 (67%) in the operating room, and four (6%) on the general surgery floor. 
Airway control methods used were nasotracheal: 14 (22%); orotracheal: 27 
(43%); FOB: 17 (27%); tracheostomy: one (2%); unknown: three (4%). No 
progression of the neurological status resulted from intubation. CONCLUSION: 
The choice of airway control in the trauma patient with CSF differs between 
anesthesiologists and surgeons. However, the method selected does not have 
an adverse affect on neurological status as long as in-line stabilization is 
maintained. The methods available are safe, effective, and acceptable. The 
recommendations of the American College of Surgeons Committee on Trauma for 
airway control with suspected cervical spine injury are useful. The 
technique utilized is dependent upon the judgment and experience of the 
intubator.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; emergency health service; respiratory failure (etiology, therapy); spine fracture (complication); 
EMTREE MEDICAL INDEX TERMS
  anesthesiology; article; clinical practice; decision tree; endotracheal intubation; human; injury; methodology; questionnaire; retrospective study; tracheostomy; traumatology; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  10155489 (http://www.ncbi.nlm.nih.gov/pubmed/10155489)
PUI
  L125123172
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=1049023X&id=doi:&atitle=Airway+control+in+trauma+patients+with+cervical+spine+fractures.&stitle=Prehospital+Disaster+Med&title=Prehospital+and+disaster+medicine+%3A+the+official+journal+of+the+National+Association+of+EMS+Physicians+and+the+World+Association+for+Emergency+and+Disaster+Medicine+in+association+with+the+Acute+Care+Foundation&volume=9&issue=1&spage=44&epage=49&aulast=Lord&aufirst=S.A.&auinit=S.A.&aufull=Lord+S.A.&coden=&isbn=&pages=44-49&date=1994&auinit1=S&auinitm=A
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1015
TITLE
  Comparison between conventional cap and one-way valve in the decannulation 
of patients with long-term tracheostomies
AUTHOR NAMES
  Hai Minh Le; Aten J.L.; Chiang J.T.; Light R.W.
AUTHOR ADDRESSES
  (Hai Minh Le; Aten J.L.; Chiang J.T.; Light R.W.) Department of Medicine, VA 
Medical Center, 5901 East Seventh St, Long Beach, CA 90822, United States.
CORRESPONDENCE ADDRESS
  R.W. Light, Department of Medicine, VA Medical Center, 5901 East Seventh St, 
Long Beach, CA 90822, United States.
FULL RECORD ENTRY DATE
  1993-12-17
SOURCE
  Respiratory Care (1993) 38:11 (1161-1167). Date of Publication: 1993
VOLUME
  38
ISSUE
  11
FIRST PAGE
  1161
LAST PAGE
  1167
DATE OF PUBLICATION
  1993
ISSN
  0098-9142
ABSTRACT
  The purpose of this study was to compare success with the conventional 
method of capping, or 'plugging,' the tracheostomy tube to success with that 
of using a one-way-airflow valve, in the decannulation of patients with 
long- term tracheostomies. MATERIALS AND METHODS: To be eligible for the 
study, the patient had to have had a tracheostomy for at least 30 days and 
be deemed by his primary care physician to be a candidate for decannulation. 
Patients who were on mechanical ventilation and patients with sleep apnea 
syndrome, severe aspiration, or clinically apparent upper-airway obstruction 
were excluded from the study. Twelve patients who were deemed ready for the 
decannulation protocol were randomly assigned either to cap or one-way 
valve. The times of occlusion were increased by 1-hour increments/day up to 
6 hours and then by 2-hour increments/day up to 24 hours. RESULTS: Ten 
patients were successfully decannulated; 5 in each group. The median time 
for decannulation was 18 days with the one-way valve and 23 days with 
standard capping. We noted no significant difference in the proportion 
successfully decannulated or time to decannulation between the two groups (p 
> 0.05). However, patients with the one-way valve appeared to be more 
comfortable. Pulmonary function testing results varied among and within 
patients because the patients were unable to cooperate or had uncuffed tubes 
in place. CONCLUSIONS: In this small group of patients, neither method 
appeared to be superior, although subjective observation suggested that 
patients appeared to be more comfortable with the one-way valve. Pulmonary 
function testing was not useful in predicting successful decannulation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  respiratory care; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; airflow; article; cannulation; cerebrovascular accident; clinical article; clinical trial; controlled study; head injury; human; lung function test; mouth carcinoma; randomized controlled trial; respiratory failure; spinal cord injury; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993352706
PUI
  L23352691
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00989142&id=doi:&atitle=Comparison+between+conventional+cap+and+one-way+valve+in+the+decannulation+of+patients+with+long-term+tracheostomies&stitle=RESPIR.+CARE&title=Respiratory+Care&volume=38&issue=11&spage=1161&epage=1167&aulast=Hai+Minh+Le&aufirst=&auinit=&aufull=Hai+Minh+Le&coden=RECAC&isbn=&pages=1161-1167&date=1993&auinit1=&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1016
TITLE
  Transoral-transpharyngeal approach to the upper cervical vertebrae
AUTHOR NAMES
  Shaha A.R.; Johnson R.; Miller J.; Milhorat T.
AUTHOR ADDRESSES
  (Shaha A.R.; Johnson R.; Miller J.; Milhorat T.) Head and Neck Service, 
Memorial Sloan-Kettering Cancer Ctr., 1275 York Avenue, New York, NY 10021, 
United States.
CORRESPONDENCE ADDRESS
  A.R. Shaha, Head and Neck Service, Memorial Sloan-Kettering Cancer Ctr., 
1275 York Avenue, New York, NY 10021, United States.
FULL RECORD ENTRY DATE
  1994-08-17
SOURCE
  American Journal of Surgery (1993) 166:4 (336-340). Date of Publication: 
1993
VOLUME
  166
ISSUE
  4
FIRST PAGE
  336
LAST PAGE
  340
DATE OF PUBLICATION
  1993
ISSN
  0002-9610
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  The classical operative approaches to the cervical spine include the 
posterior one and the anterior exposure along the sternomastoid muscle. 
However, neither of these are helpful in exposing the upper cervical 
vertebrae, especially the odontoid process, atlas, and axis. We have used 
the transoral-transpharyngeal exposure for lesions of the odontoid process 
and upper (first to third) cervical vertebrae in six patients. The 
pathologic processes included rheumatoid disease and fracture of the 
cervical vertebrae, suspected tumor with compression of the spinal cord, 
basilar invagination, and compression of the medulla. In all six patients, 
the exposure was excellent, and postoperative morbidity was minimal. 
Tracheostomy was performed routinely in all these patients. In five 
patients, vertebral stabilization was performed as a secondary procedure a 
few days after the initial anterior decompressive surgery. The 
transoral-transpharyngeal approach appears to be relatively easy. It is 
associated with minimal complications and provides excellent exposure of the 
odontoid and upper cervical vertebrae for a microneurosurgical approach. 
Modifications of this approach include incision of the soft palate, excision 
of a portion of the hard palate, and, occasionally, transmandibular median 
labio-mandibulo- glossotomy (Trotter's) approach. Although the technique was 
described initially approximately 35 years ago, this neglected anatomic 
approach will facilitate cooperative efforts between head and neck surgeons 
and neurosurgeons.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord compression (surgery); spinal cord decompression; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; cervical spine; clinical article; clinical trial; conference paper; controlled clinical trial; controlled study; human; mouth cavity; priority journal; surgical anatomy; surgical approach; surgical technique; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1994239753
MEDLINE PMID
  8214287 (http://www.ncbi.nlm.nih.gov/pubmed/8214287)
PUI
  L24240982
DOI
  10.1016/S0002-9610(05)80327-7
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0002-9610(05)80327-7
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00029610&id=doi:10.1016%2FS0002-9610%2805%2980327-7&atitle=Transoral-transpharyngeal+approach+to+the+upper+cervical+vertebrae&stitle=AM.+J.+SURG.&title=American+Journal+of+Surgery&volume=166&issue=4&spage=336&epage=340&aulast=Shaha&aufirst=A.R.&auinit=A.R.&aufull=Shaha+A.R.&coden=AJSUA&isbn=&pages=336-340&date=1993&auinit1=A&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1017
TITLE
  A methodology to evaluate motion of the unstable spine during intubation 
techniques
AUTHOR NAMES
  Donaldson III W.F.; Towers J.D.; Doctor A.; Brand A.; Donaldson V.P.
AUTHOR ADDRESSES
  (Donaldson III W.F.; Towers J.D.; Doctor A.; Brand A.; Donaldson V.P.) 3471 
Fifth Avenue, Pittsburgh, PA 15213, United States.
CORRESPONDENCE ADDRESS
  W.F. Donaldson III, 3471 Fifth Avenue, Pittsburgh, PA 15213, United States.
FULL RECORD ENTRY DATE
  1993-11-10
SOURCE
  Spine (1993) 18:14 (2020-2023). Date of Publication: 1993
VOLUME
  18
ISSUE
  14
FIRST PAGE
  2020
LAST PAGE
  2023
DATE OF PUBLICATION
  1993
ISSN
  0362-2436
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Airway management in patients with an unstable cervical spine remains a 
challenge. A video fluoroscopic technique that transfers the image to a 
floppy disk for direct measurement is described. This technique enabled 
standardized, direct measurement of the cervical spine during airway 
maneuvers before and after a C5-6 posterior instability was surgically 
created in five cadaveric specimens. Unsupported direct oral techniques 
often can cause more motion than do indirect nasal techniques, and chin 
lift/jaw thrust and cricoid pressure can cause as much motion as do some of 
the intubation techniques.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  motion; respiratory tract intubation; spine instability; 
EMTREE MEDICAL INDEX TERMS
  cervical spine; conference paper; endotracheal intubation; fluoroscopy; human; human experiment; image intensifier; nasotracheal intubation; priority journal; tracheostomy; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993315921
MEDLINE PMID
  8272952 (http://www.ncbi.nlm.nih.gov/pubmed/8272952)
PUI
  L23315906
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03622436&id=doi:&atitle=A+methodology+to+evaluate+motion+of+the+unstable+spine+during+intubation+techniques&stitle=SPINE&title=Spine&volume=18&issue=14&spage=2020&epage=2023&aulast=Donaldson+III&aufirst=W.F.&auinit=W.F.&aufull=Donaldson+III+W.F.&coden=SPIND&isbn=&pages=2020-2023&date=1993&auinit1=W&auinitm=F
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1018
TITLE
  Multichannel stimulation of phrenic nerves by epineural electrodes. Clinical 
experience and future developments
AUTHOR NAMES
  Mayr W.; Bijak M.; Girsch W.; Holle J.; Lanmuller H.; Thoma H.; Zrunek M.
AUTHOR ADDRESSES
  (Mayr W.; Bijak M.; Girsch W.; Holle J.; Lanmuller H.; Thoma H.; Zrunek M.) 
Biomedical Engineering/Physics Dept., University of Vienna, AKH, Wahringer 
Gurtel 18-20, A-1090 Vienna, Austria.
CORRESPONDENCE ADDRESS
  W. Mayr, Biomedical Engineering/Physics Dept., University of Vienna, AKH, 
Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
FULL RECORD ENTRY DATE
  1993-11-05
SOURCE
  ASAIO Journal (1993) 39:3 (M729-M735). Date of Publication: 1993
VOLUME
  39
ISSUE
  3
DATE OF PUBLICATION
  1993
ISSN
  1058-2916
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  Between 1983 and 1992, 23 patients with complete ventilatory insufficiency 
of differing etiologies were treated with an eight channel implant 
(Medimplant Inc., Vienna) for fatigue free stimulation of both phrenic 
nerves. Data for 15 patients with high spinal cord lesions (ages: 9-51 
years) are summarized: 1) level of lesion: C0, 3 patients; C1/C2, 4; C2/C3, 
8; 2) time between incident and implantation: 3-14 months; 3) diaphragm 
training: 1-22 months; 4) chronic pacing: 5-83 months; 5) tracheostomy 
closed: 7 patients; 6) living permanently at home: 13 patients; 7) 
respiratory rate per minute: 12-17; 8) duration of inspiration: 1.0-1.3 sec; 
9) tidal volume: 7- 20 ml/kg body weight; 10) volume per minute: 121-198 
ml/kg body weight; 11) pH: 7.39-7.42; 12) pCO(2): 22.9-38.6 mmHg; 13) pO(2): 
81.2-104.5 mmHg; and 14) died by December 1992, 4 patients. All currently 
available implants for phrenic pacing need an external power supply and 
radio control. The authors have developed and tested the first fully 
implantable device. Features of this implant include an electronic circuit 
based on the microcontroller MC68HC705C8; surface mounted technology (SMD); 
eight channels; constant current source adjustable to 5 mA in 256 steps, 
impulse duration: 100-1000 μsec, stimulation frequency: 1-33 Hz; and minimum 
lifetime: 3 years. The implant is programmed via bidirectional radio 
transmission using an IBM compatible computer. The dimensions, including 
battery, eight electrode connectors, and antenna, are 67 x 48 x 13 mm. The 
implant weighs 58 g. This new device may improve patients' safety and 
quality of life in the near future.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  electrode; multichannel recorder; nerve stimulation; phrenic nerve; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; breathing rate; carbon dioxide tension; child; clinical article; devices; female; home; human; implant; lung minute volume; male; oxygen tension; pH; respiratory function disorder; sleep disordered breathing; spinal cord lesion; tidal volume; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993311810
MEDLINE PMID
  8268634 (http://www.ncbi.nlm.nih.gov/pubmed/8268634)
PUI
  L23311795
DOI
  10.1097/00002480-199307000-00117
FULL TEXT LINK
  http://dx.doi.org/10.1097/00002480-199307000-00117
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=10582916&id=doi:10.1097%2F00002480-199307000-00117&atitle=Multichannel+stimulation+of+phrenic+nerves+by+epineural+electrodes.+Clinical+experience+and+future+developments&stitle=ASAIO+J.&title=ASAIO+Journal&volume=39&issue=3&spage=&epage=&aulast=Mayr&aufirst=W.&auinit=W.&aufull=Mayr+W.&coden=AJOUE&isbn=&pages=-&date=1993&auinit1=W&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1019
TITLE
  The Swedish modification of the tracheostomy tube to permit speech
AUTHOR NAMES
  Andersson G.
AUTHOR ADDRESSES
  (Andersson G.) Department of Anaesthestics, Danderyd Hospital, 182 88 
Danderyd, Sweden.
CORRESPONDENCE ADDRESS
  G. Andersson, Department of Anaesthestics, Danderyd Hospital, 182 88 
Danderyd, Sweden.
FULL RECORD ENTRY DATE
  1993-09-19
SOURCE
  Paraplegia (1993) 31:4 (203-206). Date of Publication: 1993
VOLUME
  31
ISSUE
  4
FIRST PAGE
  203
LAST PAGE
  206
DATE OF PUBLICATION
  1993
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Over the last 20 years the Respiratory Unit at Danderyd Hospital, Sweden has 
treated and rehabilitated more than 90 patients on domiciliary ventilation, 
the majority of whom require night-time ventilation. Sixteen patients (11 
men and 5 women) with high spinal cord lesions have been treated. Of these 
16 patients, 9 are using diaphragmatic pacing. Every patient has a 
customised tube. If the patient can use diaphragmatic pacing the tube, as a 
rule, is single fenestrated. In patients using the ventilator full time, the 
tube is made to fit snugly in the trachea. When such a tube fits 'as a 
bullet in its tube' there is no need for a cuff. The patient has adequate 
ventilation and the small leak around the tube also permits good speech 
function. Sometimes a PEEP-valve is used to get a better voice.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  speech articulation; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; assisted ventilation; clinical article; diaphragm; female; fenestration; human; male; positive end expiratory pressure; spinal cord lesion (diagnosis, etiology, rehabilitation); Sweden; trachea; voice; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Surgery (9)
  Otorhinolaryngology (11)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993264686
MEDLINE PMID
  8493034 (http://www.ncbi.nlm.nih.gov/pubmed/8493034)
PUI
  L23264672
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=The+Swedish+modification+of+the+tracheostomy+tube+to+permit+speech&stitle=PARAPLEGIA&title=Paraplegia&volume=31&issue=4&spage=203&epage=206&aulast=Andersson&aufirst=G.&auinit=G.&aufull=Andersson+G.&coden=PRPLB&isbn=&pages=203-206&date=1993&auinit1=G&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1020
TITLE
  Inappropriate weaning and late onset ventilatory failure of individuals with 
traumatic spinal cord injury
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Dep Physical Medicine/Rehabilitation, University of Medicine and 
Dentistry, University Hospital B-239, 150 Bergen Street, Newark, NJ, United 
States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Dep Physical Medicine/Rehabilitation, University of Medicine and 
Dentistry, University Hospital B-239, 150 Bergen Street, Newark, NJ, United 
States.
FULL RECORD ENTRY DATE
  1993-09-16
SOURCE
  Paraplegia (1993) 31:7 (430-438). Date of Publication: 1993
VOLUME
  31
ISSUE
  7
FIRST PAGE
  430
LAST PAGE
  438
DATE OF PUBLICATION
  1993
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Eight traumatic spinal cord injured (SCI) individuals are described. Four 
tetraplegic patients who were weaned from initial ventilator use despite 
severe restrictive pulmonary syndromes experienced multiple pulmonary 
complications, episodes of acute respiratory failure, and 3 of the 4 
required long term ventilatory support within 2 years of initial weaning. 
Three other SCI individuals developed chronic late-onset ventilatory failure 
17, 25, and 29 years postinjury. One other tetraplegic patient was 
mechanically ventilated for 8.2 years postinjury despite complete recovery 
of autonomous ventilatory function years earlier. Of the 6 patients 
requiring long term ventilatory support, 4 were managed by noninvasive 
techniques of intermittent positive pressure ventilation (IPPV), one by 
negative pressure body ventilators, and one by tracheostomy IPPV. At least 
one and possibly as many as 5 patients were spared bronchoscopy and/or 
pulmonary complications by using mechanical insufflation-exsufflation 
(MI-E). We conclude that patients who are weaned despite having significant 
restrictive pulmonary syndromes are at risk for ventilatory decompensation 
weeks to decades after weaning. Ongoing clinical assessment, evaluation of 
respiratory muscle function and, at times, nocturnal blood gas analyses are 
warranted in the follow up of traumatic SCI individuals.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; spinal cord injury (etiology); 
EMTREE MEDICAL INDEX TERMS
  acute respiratory failure (complication); adult; aeration; aged; article; blood gas analysis; breathing muscle; bronchoscopy; case report; clinical feature; female; human; intermittent positive pressure ventilation; lung insufficiency (complication); male; muscle function; quadriplegia; respiratory function; tracheostomy; weaning; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993262654
MEDLINE PMID
  8371934 (http://www.ncbi.nlm.nih.gov/pubmed/8371934)
PUI
  L23262640
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Inappropriate+weaning+and+late+onset+ventilatory+failure+of+individuals+with+traumatic+spinal+cord+injury&stitle=PARAPLEGIA&title=Paraplegia&volume=31&issue=7&spage=430&epage=438&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=PRPLB&isbn=&pages=430-438&date=1993&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1021
TITLE
  Complete cricotracheal separation and third cervical spinal cord transection 
following blunt neck trauma: A case report of one survivor
AUTHOR NAMES
  Chen F.H.; Fetzer J.D.
AUTHOR ADDRESSES
  (Chen F.H.; Fetzer J.D.) Department of Surgery, Woodward Hospital and Health 
Center, 900 17th St., Woodward, OK 73801, United States.
CORRESPONDENCE ADDRESS
  F.H. Chen, Department of Surgery, Woodward Hospital and Health Center, 900 
17th St., Woodward, OK 73801, United States.
FULL RECORD ENTRY DATE
  1993-08-12
SOURCE
  Journal of Trauma (1993) 35:1 (140-142). Date of Publication: 1993
VOLUME
  35
ISSUE
  1
FIRST PAGE
  140
LAST PAGE
  142
DATE OF PUBLICATION
  1993
ISSN
  0022-5282
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  We report the case of a patient who sustained a scissors-type blunt neck 
trauma and survived the following injuries: comminuted cricoid fracture, 
complete cricotracheal separation, interruption of the recurrent laryngeal 
nerves bilaterally, multiple cervical vertebral fractures, and a third 
cervical cord transection. He was rendered apneic instantly at the accident 
site and was immediately resuscitated by coworkers by mouth-to-mouth 
resuscitation. Attempts at endotracheal intubation to establish an initial 
airway caused acute airway occlusion and an emergency tracheostomy was then 
succesfully performed. He was treated by immediate stabilization of the 
cervical spine, emergency neck exploration, and early primary repair of the 
airway injury. Any patient with cervial airway injury should be assumed to 
have cervical spine injury and should have neck immobilization from the 
beginning of resuscitation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  blunt trauma (etiology); cervical spinal cord injury (complication, diagnosis); neck injury (etiology, surgery, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; clinical feature; human; larynx injury (diagnosis); male; nerve injury (diagnosis); priority journal; recurrent laryngeal nerve; resuscitation; spine stabilization; tracheostomy; treatment planning; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993220364
MEDLINE PMID
  8331704 (http://www.ncbi.nlm.nih.gov/pubmed/8331704)
PUI
  L23220350
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:&atitle=Complete+cricotracheal+separation+and+third+cervical+spinal+cord+transection+following+blunt+neck+trauma%3A+A+case+report+of+one+survivor&stitle=J.+TRAUMA&title=Journal+of+Trauma&volume=35&issue=1&spage=140&epage=142&aulast=Chen&aufirst=F.H.&auinit=F.H.&aufull=Chen+F.H.&coden=JOTRA&isbn=&pages=140-142&date=1993&auinit1=F&auinitm=H
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1022
TITLE
  Rigid spine syndrome and nocturnal alveolar hypoventilation.
AUTHOR NAMES
  Kawata A.; Suga M.; Miyamoto K.; Hirose K.; Tanabe H.
AUTHOR ADDRESSES
  (Kawata A.; Suga M.; Miyamoto K.; Hirose K.; Tanabe H.) Department of 
Neurology, Tokyo Metropolitan Neurological Hospital, Japan.
CORRESPONDENCE ADDRESS
  A. Kawata, Department of Neurology, Tokyo Metropolitan Neurological 
Hospital, Japan.
FULL RECORD ENTRY DATE
  1994-03-18
SOURCE
  Internal medicine (Tokyo, Japan) (1993) 32:8 (638-640). Date of Publication: 
Aug 1993
VOLUME
  32
ISSUE
  8
FIRST PAGE
  638
LAST PAGE
  640
DATE OF PUBLICATION
  Aug 1993
ISSN
  0918-2918
ABSTRACT
  A 17-year-old Japanese woman with rigid spine syndrome (RSS) presented with 
respiratory failure leading to CO2 narcosis. The clinical symptoms were 
drowsiness, asterixis and cardiac arrhythmias. Tracheostomy and temporary 
ventilatory support abolished these symptoms. However, polygraphic sleep 
studies without a ventilator revealed Cheyne-Stokes respiration and profound 
arterial oxygen desaturation during rapid eye movement sleep. Nocturnal 
ventilatory support improved not only nocturnal hypoxemia, but daytime blood 
gas values during spontaneous breathing. These findings indicate that the 
onset of respiratory failure is preceded by severe nocturnal hypoxemia and 
that the evaluation and control of nocturnal respiratory insufficiency is 
essential for RSS patients.
EMTREE DRUG INDEX TERMS
  oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  sleep disordered breathing (etiology, therapy); spine disease (complication); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; artificial ventilation; blood; breathing muscle; case report; Cheyne Stokes breathing (etiology, therapy); electroencephalography; female; human; hypoxemia (etiology); pathophysiology; physiology; REM sleep; respiratory failure (etiology, therapy); syndrome; 
CAS REGISTRY NUMBERS
  oxygen (7782-44-7)
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  8312662 (http://www.ncbi.nlm.nih.gov/pubmed/8312662)
PUI
  L24864063
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09182918&id=doi:&atitle=Rigid+spine+syndrome+and+nocturnal+alveolar+hypoventilation.&stitle=Intern.+Med.&title=Internal+medicine+%28Tokyo%2C+Japan%29&volume=32&issue=8&spage=638&epage=640&aulast=Kawata&aufirst=A.&auinit=A.&aufull=Kawata+A.&coden=&isbn=&pages=638-640&date=1993&auinit1=A&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1023
TITLE
  Longitudinal study of spinal deformity in Duchenne muscular dystrophy
AUTHOR NAMES
  Oda T.; Shimizu N.; Yonenobu K.; Ono K.; Nabeshima T.; Kyoh S.
AUTHOR ADDRESSES
  (Oda T.; Shimizu N.; Yonenobu K.; Ono K.; Nabeshima T.; Kyoh S.) Department 
of Orthopaedic Surgery, Osaka University Medical School, 1-1-50 Fukushima, 
Fukushima-ku, Osaka 553, Japan.
CORRESPONDENCE ADDRESS
  T. Oda, Department of Orthopaedic Surgery, Osaka University Medical School, 
1-1-50 Fukushima, Fukushima-ku, Osaka 553, Japan.
FULL RECORD ENTRY DATE
  1993-07-01
SOURCE
  Journal of Pediatric Orthopaedics (1993) 13:4 (478-488). Date of 
Publication: 1993
VOLUME
  13
ISSUE
  4
FIRST PAGE
  478
LAST PAGE
  488
DATE OF PUBLICATION
  1993
ISSN
  0271-6798
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street, Philadelphia, United 
States.
ABSTRACT
  To investigate the natural course of the spinal deformity in Duchenne 
muscular dystrophy (DMD) and its clinical relevance, longitudinal series of 
spinal radiographs and medical records of 46 patients with DMD were 
reviewed. The natural course of the deformity was classified into three 
types; type 1 (n = 21), unremittent progression of scoliosis with kyphosis; 
type 2 (n = 18), transition from kyphosis to lordosis before age 15 years; 
and type 3 (n = 7), less deformity without prominent longitudinal changes. 
Age at loss of ambulatory ability was not a predictor of type. Neither was 
the age at which the Cobb angle was 30° correlated with the rate of 
subsequent progression. Because the spinal deformity always progresses, we 
consider spinal surgery justifiable in type 1, when a certain strict 
indication exists, such as spinal deformity >30° and age <15 years in 
patients with >35% predicted value of vital capacity. In type 2, operation 
may be necessary in patients in whom Cobb angle will progress unremittently. 
There is no surgical indication for patients with type 3.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Duchenne muscular dystrophy (diagnosis, rehabilitation); kyphosis (complication, diagnosis, surgery); lordosis (complication, diagnosis, surgery); scoliosis (complication, diagnosis, surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; age; article; child; clinical article; disease course; forced expiratory volume; human; lung function; male; measurement; prognosis; spine malformation (complication, diagnosis, surgery); spine radiography; spine surgery; tracheotomy; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
  Radiology (14)
  Rehabilitation and Physical Medicine (19)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993174672
MEDLINE PMID
  8370781 (http://www.ncbi.nlm.nih.gov/pubmed/8370781)
PUI
  L23174658
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02716798&id=doi:&atitle=Longitudinal+study+of+spinal+deformity+in+Duchenne+muscular+dystrophy&stitle=J.+PEDIATR.+ORTHOP.&title=Journal+of+Pediatric+Orthopaedics&volume=13&issue=4&spage=478&epage=488&aulast=Oda&aufirst=T.&auinit=T.&aufull=Oda+T.&coden=JPORD&isbn=&pages=478-488&date=1993&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1024
TITLE
  Late post-tracheostomy airway complications in patients with central nervous 
system injuries
ORIGINAL (NON-ENGLISH) TITLE
  Központi idegrendszeri sérültek késöi posttracheostomiás légúti 
szövödményei.
AUTHOR NAMES
  Kas J.; Baranyai L.; Lantos A.; Kertész G.; Fehér M.; Vass M.
AUTHOR ADDRESSES
  (Kas J.; Baranyai L.; Lantos A.; Kertész G.; Fehér M.; Vass M.) Sebészeti 
Osztály, Budai MAV Kórház.
CORRESPONDENCE ADDRESS
  J. Kas, Sebészeti Osztály, Budai MAV Kórház.
FULL RECORD ENTRY DATE
  1993-08-18
SOURCE
  Orvosi hetilap (1993) 134:24 (1297-1301). Date of Publication: 13 Jun 1993
VOLUME
  134
ISSUE
  24
FIRST PAGE
  1297
LAST PAGE
  1301
DATE OF PUBLICATION
  13 Jun 1993
ISSN
  0030-6002
ABSTRACT
  At decannulation or often weeks later some of the patients undergone 
long-term mechanical ventilation through tracheostoma reveal symptoms of 
airway stenosis. Posttracheostomy airway complications detected during the 
rehabilitation of 34 patients with central nervous system injury are 
presented. Endoscopic examinations (total 130) were performed with Olympus 
BF B3 and OES 20-type fiberscopes and Friedel-type rigid bronchoscopes under 
local or general anaesthesia. Stridor (20 cases) and possible decannulation 
(10 cases) were the main indications of the first endoscopic examinations. 
Stridor was caused by tracheal (12 cases) and laryngeal (8 cases) stenosis. 
With six patients decannulation was possible after the first endoscopy. 
Removal of granulomas and sutures was successful in 8 cases. Rigid 
bronchoscopic dilatations were temporarily successful in 7 cases, but in 
five of them it had to be repeated on emergency. Further therapeutic 
interventions were: recannulation (3 cases), retracheostomy (4 cases), 
implantation of silicon T-endoprothesis (5 cases), tracheal resection (4 
cases). Three patients are discussed in details. Eliminating airway 
complications largely contributed to rehabilitation of the nervous and 
musculoskeletal system, improved the quality of life, and in acute cases it 
was a life-saving measure. In order to prevent the development of late 
airway complications or detect them in time, it is recommended to have an 
endoscopic protocol following every tracheostomy: 1. at the time of 
decannulation 2. at closing the trachea and 3. 2-3 months after 
decannulation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (etiology, therapy); tracheostomy (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; brain injury (complication); bronchoscopy; case report; female; fiber optics; human; investigative procedures; laryngoscopy; larynx stenosis (complication, diagnosis, etiology, therapy); male; multiple trauma (complication); spinal cord injury (complication); trachea stenosis (complication, diagnosis, etiology, therapy); traffic accident; 
LANGUAGE OF ARTICLE
  Hungarian
MEDLINE PMID
  8332346 (http://www.ncbi.nlm.nih.gov/pubmed/8332346)
PUI
  L23833781
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00306002&id=doi:&atitle=Late+post-tracheostomy+airway+complications+in+patients+with+central+nervous+system+injuries&stitle=Orv+Hetil&title=Orvosi+hetilap&volume=134&issue=24&spage=1297&epage=1301&aulast=Kas&aufirst=J.&auinit=J.&aufull=Kas+J.&coden=&isbn=&pages=1297-1301&date=1993&auinit1=J&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1025
TITLE
  Rigid spine syndrome presenting with respiratory failure--report of one 
case.
AUTHOR NAMES
  Lin S.J.; Wang P.J.; Lin M.Y.; Shen Y.Z.
AUTHOR ADDRESSES
  (Lin S.J.; Wang P.J.; Lin M.Y.; Shen Y.Z.) Department of Pediatrics, 
National Taiwan University Hospital, Taipei, R.O.C.
CORRESPONDENCE ADDRESS
  S.J. Lin, Department of Pediatrics, National Taiwan University Hospital, 
Taipei, R.O.C.
FULL RECORD ENTRY DATE
  1993-10-04
SOURCE
  Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao 
er ke yi xue hui (1993) 34:3 (216-222). Date of Publication: 1993 May-Jun
VOLUME
  34
ISSUE
  3
FIRST PAGE
  216
LAST PAGE
  222
DATE OF PUBLICATION
  1993 May-Jun
ISSN
  0001-6578
ABSTRACT
  A case of rigid spine syndrome presenting with respiratory failure was 
reported. A seven-year-old girl had had dyspnea and orthopnea for one month. 
Symptoms had aggravated gradually and she was in a state of respiratory 
failure on arrival at our hospital. There was no evidence of active lung 
lesions and response to mechanical ventilation was good. Physical 
examination revealed an extremely thin girl with marked flexion limitation 
of neck and severe wasting of sternocleidomastoid and intercostal muscles. 
Serum creatine phosphokinase was moderately elevated (801 IU/L). Muscle 
biopsy specimen obtained from the right quadriceps femoris revealed 
increased perimyseal connective tissue and marked Type II fiber atrophy. 
Electromyography of left paraspinal muscles demonstrated small amplitude, 
short duration motor unit potentials. She received tracheostomy and a 
home-care ventilator use during sleep. Ventilatory insufficiency, though 
rare, should be anticipated in patients with rigid spine syndrome, and 
timely ventilatory support should be given.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  muscle disease (complication, diagnosis); respiratory failure (etiology); spine disease (complication, diagnosis); 
EMTREE MEDICAL INDEX TERMS
  article; case report; child; female; human; syndrome; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  8368070 (http://www.ncbi.nlm.nih.gov/pubmed/8368070)
PUI
  L23926019
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016578&id=doi:&atitle=Rigid+spine+syndrome+presenting+with+respiratory+failure--report+of+one+case.&stitle=Zhonghua+Min+Guo+Xiao+Er+Ke+Yi+Xue+Hui+Za+Zhi&title=Zhonghua+Minguo+xiao+er+ke+yi+xue+hui+za+zhi+%5BJournal%5D.+Zhonghua+Minguo+xiao+er+ke+yi+xue+hui&volume=34&issue=3&spage=216&epage=222&aulast=Lin&aufirst=S.J.&auinit=S.J.&aufull=Lin+S.J.&coden=&isbn=&pages=216-222&date=1993&auinit1=S&auinitm=J
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1026
TITLE
  Anterior surgery of the upper part of the cervical spine by prevascular 
extraoral approach.
AUTHOR NAMES
  Laus M.; Alfonso C.; Laguardia A.M.; Giunti A.
AUTHOR ADDRESSES
  (Laus M.; Alfonso C.; Laguardia A.M.; Giunti A.) Clinica Ortopedica 
dell'Università, Istituto Ortopedico Rizzoli, Bologna.
CORRESPONDENCE ADDRESS
  M. Laus, Clinica Ortopedica dell'Università, Istituto Ortopedico Rizzoli, 
Bologna.
FULL RECORD ENTRY DATE
  1993-09-07
SOURCE
  La Chirurgia degli organi di movimento (1993) 78:2 (65-75). Date of 
Publication: 1993 Apr-Jun
VOLUME
  78
ISSUE
  2
FIRST PAGE
  65
LAST PAGE
  75
DATE OF PUBLICATION
  1993 Apr-Jun
ISSN
  0009-4749
ABSTRACT
  Anterior surgery of the upper part of the cervical spine, that is, proximal 
to C3, may be performed by transoral approach, possibly enlarged by 
glossomandibulotomy, by a retrovascular extraoral approach, or by a 
prevascular extraoral approach. The authors describe the surgical method of 
prevascular extraoral approach that allowed them to effectively treat 
osteoma localized at C2 and C3, post-laminectomy instability at C3 and C4, 
solitary metastasis at C3. As compared to transoral surgery the prevascular 
extraoral approach has the advantage of avoiding the risk of infection from 
germs in the oral cavity and of allowing for easier postoperative 
management, avoiding tracheotomy and/or prolonged dysphagia. As compared to 
a retrovascular approach the prevascular approach obtains a truly anterior 
exposure instead of an anterolateral one. Prevascular extraoral approach 
should thus be used whenever possible. Transoral surgery is indicated for 
decompression, of the brainstem and a bilateral retrovascular approach may 
be used to perform anterolateral fusion at C1-C2.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine (surgery); 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; female; human; male; metastasis; middle aged; osteoma (surgery); procedures; spinal cord tumor (surgery); squamous cell carcinoma (surgery); vascularization; 
LANGUAGE OF ARTICLE
  English, Italian
MEDLINE PMID
  8344077 (http://www.ncbi.nlm.nih.gov/pubmed/8344077)
PUI
  L23917350
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00094749&id=doi:&atitle=Anterior+surgery+of+the+upper+part+of+the+cervical+spine+by+prevascular+extraoral+approach.&stitle=Chir+Organi+Mov&title=La+Chirurgia+degli+organi+di+movimento&volume=78&issue=2&spage=65&epage=75&aulast=Laus&aufirst=M.&auinit=M.&aufull=Laus+M.&coden=&isbn=&pages=65-75&date=1993&auinit1=M&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1027
TITLE
  Tracheostomy in spinal cord injured: Frequency and follow up
AUTHOR NAMES
  Biering-Sorensen M.; Biering-Sorensen F.
AUTHOR ADDRESSES
  (Biering-Sorensen M.; Biering-Sorensen F.) Centre Spinal Cord Injured, 
Rigshospitalet, National University Hospital, Havnevej 25, DK-3100 Hornbaek, 
Denmark.
CORRESPONDENCE ADDRESS
  M. Biering-Sorensen, Centre Spinal Cord Injured, Rigshospitalet, National 
University Hospital, Havnevej 25, DK-3100 Hornbaek, Denmark.
FULL RECORD ENTRY DATE
  1993-01-15
SOURCE
  Paraplegia (1992) 30:9 (656-660). Date of Publication: 1992
VOLUME
  30
ISSUE
  9
FIRST PAGE
  656
LAST PAGE
  660
DATE OF PUBLICATION
  1992
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Among 600 traumatic spinal cord injured (SCI) patients admitted during a 20 
year period, 67 had a tracheostomy performed (11.2%). Of these 67 patients 
46 had a cervical SCI. A concomitant thoracic trauma had occurred 
significantly more often in the group with thoracic or lumbar SCI than in 
those with a cervical SCI. The period from injury to tracheostomy was 0-48 
days (median 4.4 days), and from tracheostomy to decannulation 3-167 days 
(median 31 days). At follow up 20 (30%) had died, primarily because of 
respiratory problems. Of the remaining 47 patients, 43 (91%) responded to a 
follow up questionnaire 3.5-21.7 years (median 10.4 years) after the injury. 
In the follow up 53% reported never to have had any inconvenience or trouble 
related to the tracheosotmy. The majord inconvenience among the others had 
been of cosmetic tracheostomy. The major inconvenience among the others had 
been of cosmetic origin (28%), and 3 had had a surgical revision for this 
reason. At the time of follow up 9 patients (21%) still had certain 
complaints, primarily described as difficulty in swallowing. 
Minitracheostomy might in the future reduce reduce the number of these 
complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing disorder (complication, surgery); spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; article; child; controlled study; human; major clinical study; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993010941
MEDLINE PMID
  1408343 (http://www.ncbi.nlm.nih.gov/pubmed/1408343)
PUI
  L23010941
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Tracheostomy+in+spinal+cord+injured%3A+Frequency+and+follow+up&stitle=PARAPLEGIA&title=Paraplegia&volume=30&issue=9&spage=656&epage=660&aulast=Biering-Sorensen&aufirst=M.&auinit=M.&aufull=Biering-Sorensen+M.&coden=PRPLB&isbn=&pages=656-660&date=1992&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1028
TITLE
  Ventilatory support at home in children with spinal muscular atrophies (SMA)
AUTHOR NAMES
  Barois A.; Estournet-Mathiaud B.
AUTHOR ADDRESSES
  (Barois A.; Estournet-Mathiaud B.) Hopital Raymond Poincare, 92380 Garches, 
France.
CORRESPONDENCE ADDRESS
  A. Barois, Hopital Raymond Poincare, 92380 Garches, France.
FULL RECORD ENTRY DATE
  1993-02-22
SOURCE
  European Respiratory Review (1992) 2:10 (319-322). Date of Publication: 1992
VOLUME
  2
ISSUE
  10
FIRST PAGE
  319
LAST PAGE
  322
DATE OF PUBLICATION
  1992
ISSN
  0905-9180
ABSTRACT
  Early management of children diagnosed as having spinal muscular atrophies 
(SMA) is important since development of the lung may be affected in children 
who have paralysis of respiratory muscles. We report our experience of 
ventilatory support at home in more than 100 children with SMA. In each 
case, we explain the operating conditions. Oral positive pressure breathing 
with periodic hyperinsufflation is always used as early as possible if there 
are no severe swallowing disorders. Nasal ventilation has been used in nine 
patients under two yrs of age, in 14 older children and in two adults. 
Endotracheal ventilation by tracheostomy was used 24 times; three children 
subsequently died. Earlier management of such children, as soon as diagnosis 
is performed, gives a better quality of life for babies in the acute forms 
and a good sociological integration to adult life for the others.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  assisted ventilation; chronic respiratory failure (therapy); spinal muscular atrophy; 
EMTREE MEDICAL INDEX TERMS
  breathing muscle; child; conference paper; home care; human; lung development; quality of life; tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993046334
PUI
  L23046334
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09059180&id=doi:&atitle=Ventilatory+support+at+home+in+children+with+spinal+muscular+atrophies+%28SMA%29&stitle=EUR.+RESPIR.+REV.&title=European+Respiratory+Review&volume=2&issue=10&spage=319&epage=322&aulast=Barois&aufirst=A.&auinit=A.&aufull=Barois+A.&coden=EREWE&isbn=&pages=319-322&date=1992&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1029
TITLE
  Pulmonary issues in quadriplegia
AUTHOR NAMES
  Sortor S.
AUTHOR ADDRESSES
  (Sortor S.) Spinal Cord Injury, Dallas Rehabilitation Institute, 9713 Harry 
Hines, Dallas, TX, United States.
CORRESPONDENCE ADDRESS
  S. Sortor, Spinal Cord Injury, Dallas Rehabilitation Institute, 9713 Harry 
Hines, Dallas, TX, United States.
FULL RECORD ENTRY DATE
  1993-02-22
SOURCE
  European Respiratory Review (1992) 2:10 (330-334). Date of Publication: 1992
VOLUME
  2
ISSUE
  10
FIRST PAGE
  330
LAST PAGE
  334
DATE OF PUBLICATION
  1992
ISSN
  0905-9180
ABSTRACT
  Pulmonary concerns in quadriplegia caused by neuromuscular disorders and 
traumatic injury have been reviewed. Whatever the cause of the quadriplegia 
the initial approach to the patient is extensive evaluation. This includes 
physical assessment, pulmonary function testing, measurement of 'mechanical' 
inspiratory capacity, arterial blood gas or saturation measurement and 
sometimes monitoring of ventilation during sleep. After evaluation an 
appropriate treatment programme is commenced and the ventilation system 
selected. Since 1984 sixty two ventilator dependent quadriplegic patients 
have been treated in the Spinal Cord Injury Dallas Rehabilitation Unit. 
Fifty eight patients were discharged to home, four remained hospitalized. 
Fifty two were placed on non-tracheostomy forms of ventilation by discharge. 
The aetiology of the quadriplegia was 40 neuromuscular disorders (20 polio, 
3 amyotrophic lateral sclerosis (ALS), 2 spina bifida, 9 muscular dystrophy, 
6 spinal muscular atrophy (SMA) and 22 traumatic injuries. Seven deaths have 
been reported. One child with SMA discontinued support after 3 months. 
Treatment focused on prevention of abnormal lung and chest wall growth, 
chest wall rigidity and atelectasis. Assisted coughing is freely used to 
prevent secretion retention and pneumonia. The overall goal is to minimize 
disability and return patients to the community.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lung complication; quadriplegia; respiratory failure (complication, rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; conference paper; human; neuromuscular disease; spinal cord injury; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1993046336
PUI
  L23046336
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09059180&id=doi:&atitle=Pulmonary+issues+in+quadriplegia&stitle=EUR.+RESPIR.+REV.&title=European+Respiratory+Review&volume=2&issue=10&spage=330&epage=334&aulast=Sortor&aufirst=S.&auinit=S.&aufull=Sortor+S.&coden=EREWE&isbn=&pages=330-334&date=1992&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1030
TITLE
  Excessive atlanto-occipital flexion as a cause of complete airway 
obstruction following anterior cervical spine fusion
AUTHOR NAMES
  Szabo M.D.; Crosby G.
AUTHOR ADDRESSES
  (Szabo M.D.; Crosby G.) Department of Anesthesia, Massachusetts General 
Hospital, 32 Fruit Street, Boston, MA 02114, United States.
CORRESPONDENCE ADDRESS
  M.D. Szabo, Department of Anesthesia, Massachusetts General Hospital, 32 
Fruit Street, Boston, MA 02114, United States.
FULL RECORD ENTRY DATE
  1992-09-13
SOURCE
  Journal of Clinical Anesthesia (1992) 4:4 (328-330). Date of Publication: 
1992
VOLUME
  4
ISSUE
  4
FIRST PAGE
  328
LAST PAGE
  330
DATE OF PUBLICATION
  1992
ISSN
  0952-8180
BOOK PUBLISHER
  Elsevier Inc., 360 Park Avenue South, New York, United States.
ABSTRACT
  This report describes complete airway obstruction following anterior 
cervical fusion caused by extreme, fixed flexion of the neck in a halo 
device. The causes and treatment of such an airway complication are 
reviewed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction (etiology, surgery, therapy); anterior spine fusion; atlantooccipital joint; joint laxity (etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; cervical spine; endotracheal intubation; extubation; head position; human; male; orthopedic equipment; spine instability (etiology); tracheostomy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1992267887
MEDLINE PMID
  1419015 (http://www.ncbi.nlm.nih.gov/pubmed/1419015)
PUI
  L22267886
DOI
  10.1016/0952-8180(92)90140-V
FULL TEXT LINK
  http://dx.doi.org/10.1016/0952-8180(92)90140-V
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=09528180&id=doi:10.1016%2F0952-8180%2892%2990140-V&atitle=Excessive+atlanto-occipital+flexion+as+a+cause+of+complete+airway+obstruction+following+anterior+cervical+spine+fusion&stitle=J.+CLIN.+ANESTH.&title=Journal+of+Clinical+Anesthesia&volume=4&issue=4&spage=328&epage=330&aulast=Szabo&aufirst=M.D.&auinit=M.D.&aufull=Szabo+M.D.&coden=JCLBE&isbn=&pages=328-330&date=1992&auinit1=M&auinitm=D
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1031
TITLE
  Hypoventilation and apnea in children during mechanically assisted 
ventilation
AUTHOR NAMES
  Gilgoff I.S.; Peng R.-C.; Keens T.G.
AUTHOR ADDRESSES
  (Gilgoff I.S.; Peng R.-C.; Keens T.G.) Rancho Los Amigos Medical Center, 
7601 East Imperial Hwy, Downey, CA 90242, United States.
CORRESPONDENCE ADDRESS
  I.S. Gilgoff, Rancho Los Amigos Medical Center, 7601 East Imperial Hwy, 
Downey, CA 90242, United States.
FULL RECORD ENTRY DATE
  1992-07-29
SOURCE
  Chest (1992) 101:6 (1500-1506). Date of Publication: 1992
VOLUME
  101
ISSUE
  6
FIRST PAGE
  1500
LAST PAGE
  1506
DATE OF PUBLICATION
  1992
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  Uncuffed tracheostomy tubes are used for long-term mechanical ventilation in 
children. However, upper airway mechanics differ between sleep and 
wakefulness; this may affect air leak around tracheostomies. We studied 19 
children with high cervical spinal cord injury on portable positive pressure 
ventilators, age range birth to 19 years. Ventilator settings were adjusted 
while awake to achieve PaCO(2) <45 mm Hg and PO(2) >90 mm Hg. Clinically 
several children with uncuffed tracheostomies became unstable at night with 
seizures and sleep disruption. Nine of 11 children on volume controlled 
systems were found to be inadequately ventilated during sleep. Substitution 
with a cuffed tracheostomy allowed adequate ventilation both awake and 
asleep, suggesting that inadequate ventilation during sleep was due to an 
uncompensated leak around the uncuffed tracheostomy. To avoid cuffed 
tracheostomies, eight children received pressure controlled ventilation. Gas 
exchange was adequate throughout the day and night. We conclude that 
children receiving volume controlled mechanical ventilation via uncuffed 
tracheostomy tubes can exhibit hypoventilation due to uncompensated air 
leak. Pressure controlled ventilation improves adequacy of gas exchange 
during sleep and wakefulness.
EMTREE DRUG INDEX TERMS
  carbon dioxide (endogenous compound); oxygen (endogenous compound); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  apnea (etiology); assisted ventilation; child care; hypoventilation (etiology); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; arterial gas; article; artificial ventilation; child; clinical article; controlled study; cuff; endotracheal tube; female; human; infant; lung gas exchange; male; newborn; priority journal; respiratory care; sleep; tracheostomy; wakefulness; 
CAS REGISTRY NUMBERS
  carbon dioxide (124-38-9, 58561-67-4)
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1992218177
MEDLINE PMID
  1600764 (http://www.ncbi.nlm.nih.gov/pubmed/1600764)
PUI
  L22218176
DOI
  10.1378/chest.101.6.1500
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.101.6.1500
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.101.6.1500&atitle=Hypoventilation+and+apnea+in+children+during+mechanically+assisted+ventilation&stitle=CHEST&title=Chest&volume=101&issue=6&spage=1500&epage=1506&aulast=Gilgoff&aufirst=I.S.&auinit=I.S.&aufull=Gilgoff+I.S.&coden=CHETB&isbn=&pages=1500-1506&date=1992&auinit1=I&auinitm=S
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1032
TITLE
  Paraplegia after spinal anaesthesia
ORIGINAL (NON-ENGLISH) TITLE
  PARAPLEGIE APRES RACHIANESTHESIE
AUTHOR NAMES
  Bessac B.; Levy R.; Chauvin M.
AUTHOR ADDRESSES
  (Bessac B.; Levy R.; Chauvin M.) Service d'Anesthesie/Reanimation, Hopital 
Ambroise-Pare, 9, Avenue Charles-de-Gaulle, 92100 Boulogne, France.
CORRESPONDENCE ADDRESS
  B. Bessac, Service d'Anesthesie/Reanimation, Hopital Ambroise-Pare, 9, 
Avenue Charles-de-Gaulle, 92100 Boulogne, France.
FULL RECORD ENTRY DATE
  1992-06-02
SOURCE
  Annales Francaises d'Anesthesie et de Reanimation (1992) 11:2 (218-220). 
Date of Publication: 1992
VOLUME
  11
ISSUE
  2
FIRST PAGE
  218
LAST PAGE
  220
DATE OF PUBLICATION
  1992
ISSN
  0750-7658
BOOK PUBLISHER
  Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex, 
France.
ABSTRACT
  A case of paraplegia occurring after a spinal anaesthetic is reported. The 
79-year-old man was admitted for a fractured neck of femur. Twenty years 
previously, he had had pharyngeal surgery and a tracheostomy. He had also 
undergone a prostatectomy for prostate cancer, and had been on oestrogen 
therapy for two years. He complained of dyspnoea at rest and his chest film 
showed diffuse pulmonary opacities. In order to avoid possible intubation 
and respiratory complications, spinal anaesthesia was performed without any 
problems in the L4 space. After the surgery, the patient recovered all his 
motor and sensory functions in the lower limbs. On the second postoperative 
day, he suffered from a motor paralysis of the right leg, which spread to 
the left leg on the fourth day. NMR imaging showed several vertebral 
metastases, together with anterior and lateral epidural invasion responsible 
for cord compression. Treatment with tetracosactide was begun, but the 
patient died six weeks later in his home, not having recovered any 
neurological function at all in his lower limbs. In fact, it was only after 
the procedure that the anaesthetist was informed that, at the time the 
prostate cancer had been diagnosed, vertebral body metastases, of which the 
patient had not been informed, were already present. The part played by the 
spinal anaesthetic in the occurrence of the paraplegia is not clear. It is a 
reminder that such a technique should be used with extreme care in patients 
having a neoplasm with often a very high incidence of vertebral metastases.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  bupivacaine (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  paraplegia (complication, side effect); spinal anesthesia; 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; cervical spine fracture (surgery); human; intrathecal drug administration; male; 
CAS REGISTRY NUMBERS
  bupivacaine (18010-40-7, 2180-92-9, 55750-21-5)
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Forensic Science Abstracts (49)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  French, English
EMBASE ACCESSION NUMBER
  1992157925
MEDLINE PMID
  1503298 (http://www.ncbi.nlm.nih.gov/pubmed/1503298)
PUI
  L22157924
DOI
  10.1016/S0750-7658(05)80017-6
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0750-7658(05)80017-6
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=07507658&id=doi:10.1016%2FS0750-7658%2805%2980017-6&atitle=Paraplegia+after+spinal+anaesthesia&stitle=ANN.+FR.+ANESTH.+REANIM.&title=Annales+Francaises+d%27Anesthesie+et+de+Reanimation&volume=11&issue=2&spage=218&epage=220&aulast=Bessac&aufirst=B.&auinit=B.&aufull=Bessac+B.&coden=AFARE&isbn=&pages=218-220&date=1992&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 1033
TITLE
  Percutaneous tracheostomy after trauma and critical illness
AUTHOR NAMES
  Ivatury R.; Siegel J.H.; Stahl W.M.; Simon R.; Scorpio R.; Gens D.R.
AUTHOR ADDRESSES
  (Ivatury R.; Siegel J.H.; Stahl W.M.; Simon R.; Scorpio R.; Gens D.R.) 
Department of Surgery, New Jersey Trauma Center, New Jersey Medical 
School:UMDNJ, 150 Bergen Street, Newark, NJ 07103-2406, United States.
CORRESPONDENCE ADDRESS
  J.H. Siegel, Department of Surgery, New Jersey Trauma Center, New Jersey 
Medical School:UMDNJ, 150 Bergen Street, Newark, NJ 07103-2406, United 
States.
FULL RECORD ENTRY DATE
  1992-05-24
SOURCE
  Journal of Trauma (1992) 32:2 (133-140). Date of Publication: 1992
VOLUME
  32
ISSUE
  2
FIRST PAGE
  133
LAST PAGE
  140
DATE OF PUBLICATION
  1992
ISSN
  0022-5282
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  A method of percutaneous tracheostomy (PT) using a tracheostome, which 
permits insertion of a full-sized cuffed tracheostomy tube, was evaluated in 
61 critically ill or injured patients (89% had trauma). Of the 54 trauma 
patients, 65% had brain injuries, 14% had injuries to the cervical spinal 
cord, 33% had face or jaw injuries, and 15% had lung injuries. The 
indications for PT were coma (46%), acute airway obstruction (5%), face or 
jaw injury (20%), pneumonitis (39%), adult respiratory distress syndrome 
(12%), and sepsis (21%). Tracheostomy was done in 51% of all cases 
specifically for managing pulmonary secretions, in 37% for prolonged 
intubation, and in 25% for neurologic lesions. The tracheostomy was done as 
an emergency in 5%, as urgent in 28%, and electively in 77%. Percutaneous 
tracheostomy was successful in 90% of the cases, and in 8% it was converted 
to a surgical tracheostomy after an initial percutaneous attempt. In 46% it 
was performed at the bedside, in 46% in the operating room, and in 7% in the 
emergency suite. A full-sized tracheostomy tube (6 to 8) was used in all 
cases and was considered optimal or larger than needed in 87% of cases. With 
three exceptions the complications of PT were minor, but 30% of the patients 
died of their primary disease. In one case death occurred because of 
bronchospasm and cardiac arrest during the PT, but appeared to be 
independent of the type of tracheostomy. Healing after in-hospital removal 
(37%) was excellent in 95% of cases and 97% of physicians indicated that 
they would use the device again.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  critical illness; injury (etiology, surgery); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; adult respiratory distress syndrome (etiology, surgery); airway obstruction (etiology, surgery); article; brain injury (surgery); cannula; cervical spinal cord injury (surgery); coma (etiology, surgery); emergency treatment; face injury (surgery); female; healing; human; intubation; jaw fracture (surgery); lung injury (surgery); major clinical study; male; mortality; pneumonia (etiology, surgery); priority journal; sepsis (etiology, surgery); surgical technique; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1992150646
MEDLINE PMID
  1740791 (http://www.ncbi.nlm.nih.gov/pubmed/1740791)
PUI
  L22150645
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:&atitle=Percutaneous+tracheostomy+after+trauma+and+critical+illness&stitle=J.+TRAUMA&title=Journal+of+Trauma&volume=32&issue=2&spage=133&epage=140&aulast=Ivatury&aufirst=R.&auinit=R.&aufull=Ivatury+R.&coden=JOTRA&isbn=&pages=133-140&date=1992&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1034
TITLE
  Anterior surgery of the upper cervical spine.
AUTHOR NAMES
  Louis R.
AUTHOR ADDRESSES
  (Louis R.) Service d'Orthopédie-Traumatologie et Chirurgie Vertébrale, 
Hopital de la Conception, Marseille, France.
CORRESPONDENCE ADDRESS
  R. Louis, Service d'Orthopédie-Traumatologie et Chirurgie Vertébrale, 
Hopital de la Conception, Marseille, France.
FULL RECORD ENTRY DATE
  1992-06-24
SOURCE
  La Chirurgia degli organi di movimento (1992) 77:1 (75-80). Date of 
Publication: 1992 Jan-Mar
VOLUME
  77
ISSUE
  1
FIRST PAGE
  75
LAST PAGE
  80
DATE OF PUBLICATION
  1992 Jan-Mar
ISSN
  0009-4749
ABSTRACT
  The authors report the results obtained in a series of more than 80 cases 
submitted to 76 operations of the upper cervical spine by transoral approach 
with a minimum follow-up of two years. The cases include: 15 unstable 
fractures or non-union of the odontoid processes; 28 cases of post-traumatic 
instability of C1-C2 level without fracture of the odontoid process; 13 
cases of rheumatoid arthritis with instability at C1-C2; 14 cases of severe 
anomalies of the craniovertebral junction, often associated with basilar 
impression and spinal cord compression, of which 7 cases presented with 
tetraparesis; 6 malignant tumors. The method used involves an anterior 
transoral approach, more often without tracheotomy, and with exposure of the 
anterior aspect of the atlas and of the odontoid process by means of a 
midline incision of the posterior wall of the pharynx. When spinal cord 
lesion was present, decompression and reconstruction by bone grafts taken 
from the iliac crest were performed. In nearly all of the cases 
osteosynthesis with an anterior plate was used. Complications were mild. 
There were two cases of infection, observed at the onset of our experience, 
which were resolved after removal of the instrumentation. There was 
loosening of a screw in three cases; this was eliminated through the 
digestive tube with no consequences. There were no early intra- or 
postoperative deaths. Consolidation was obtained in most of the patients, 
and only in three cases did we observe a loss of postoperative reduction. 
Among patients affected with tetraparesis we observed many cases of 
neurological recovery.(ABSTRACT TRUNCATED AT 250 WORDS)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine (surgery); 
EMTREE MEDICAL INDEX TERMS
  article; congenital malformation; dislocation (surgery); female; human; injury; male; methodology; odontoid process (surgery); osteosynthesis; postoperative complication (epidemiology); radiography; spinal cord tumor (surgery); spine fracture (surgery); spine fusion; 
LANGUAGE OF ARTICLE
  English, Italian
MEDLINE PMID
  1587165 (http://www.ncbi.nlm.nih.gov/pubmed/1587165)
PUI
  L22926754
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00094749&id=doi:&atitle=Anterior+surgery+of+the+upper+cervical+spine.&stitle=Chir+Organi+Mov&title=La+Chirurgia+degli+organi+di+movimento&volume=77&issue=1&spage=75&epage=80&aulast=Louis&aufirst=R.&auinit=R.&aufull=Louis+R.&coden=&isbn=&pages=75-80&date=1992&auinit1=R&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1035
TITLE
  A case of rigid spine syndrome associated with severe respiratory failure
AUTHOR NAMES
  Nakagawa M.; Kubota R.; Nakamura A.; Fujiyama J.; Suehara M.
AUTHOR ADDRESSES
  (Nakagawa M.; Kubota R.; Nakamura A.; Fujiyama J.; Suehara M.) Third 
Department of Internal Medicine, Kagoshima University, Kagoshima-shi 890
CORRESPONDENCE ADDRESS
  Third Department of Internal Medicine, Kagoshima University, Kagoshima-shi 
890
FULL RECORD ENTRY DATE
  1992-02-11
SOURCE
  Clinical Neurology (1991) 31:9 (997-1001). Date of Publication: 1991
VOLUME
  31
ISSUE
  9
FIRST PAGE
  997
LAST PAGE
  1001
DATE OF PUBLICATION
  1991
ISSN
  0009-918X
BOOK PUBLISHER
  Societas Neurologica Japonica, 31-21 Yushima 2-chome, Bunkyo-ku, Tokyo, 
Japan.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  myopathy (etiology); respiratory failure (etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; human; male; rigid spine syndrome (diagnosis); tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English, Japanese
EMBASE ACCESSION NUMBER
  1992043123
MEDLINE PMID
  1769165 (http://www.ncbi.nlm.nih.gov/pubmed/1769165)
PUI
  L22043123
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0009918X&id=doi:&atitle=A+case+of+rigid+spine+syndrome+associated+with+severe+respiratory+failure&stitle=CLIN.+NEUROL.&title=Clinical+Neurology&volume=31&issue=9&spage=997&epage=1001&aulast=Nakagawa&aufirst=M.&auinit=M.&aufull=Nakagawa+M.&coden=RISHD&isbn=&pages=997-1001&date=1991&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1036
TITLE
  Alternative methods of ventilatory support for the patient with ventilatory 
failure due to spinal cord injury.
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Department of Rehabilitation Medicine, University Hospital 
B-239, New Jersey Medical School-UMDNJ, Newark 07103.
CORRESPONDENCE ADDRESS
  J.R. Bach, Department of Rehabilitation Medicine, University Hospital B-239, 
New Jersey Medical School-UMDNJ, Newark 07103.
FULL RECORD ENTRY DATE
  1992-01-07
SOURCE
  The Journal of the American Paraplegia Society (1991) 14:4 (158-174). Date 
of Publication: Oct 1991
VOLUME
  14
ISSUE
  4
FIRST PAGE
  158
LAST PAGE
  174
DATE OF PUBLICATION
  Oct 1991
ISSN
  0195-2307
ABSTRACT
  Ventilatory insufficiency and impaired airway secretion clearance are common 
complications of spinal cord injury (SCI) and can lead to respiratory 
failure which is the leading cause of death in both the acute and chronic 
stages. Standard invasive management options such as intubation, 
tracheostomy and electrophrenic respiration have been reviewed. The review 
findings are consistent with our clinical experience in that these invasive 
options appear to entail unacceptably high morbidity and risks of mortality. 
A number of detailed parameters are suggested for evaluating the respiratory 
functioning of the individual in order to determine the most acceptable and 
successful noninvasive systems for both ventilatory support and evacuation 
of airway secretions. They are physiological substitutes for the action of 
the inspiratory and expiratory muscles. These techniques are described in 
detail. We conclude that noninvasive techniques can safely and effectively 
obviate the need for intubation, tracheostomy and electrophrenic pacemakers 
in appropriate individuals with SCI.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; respiratory failure (etiology, rehabilitation); spinal cord injury (complication); 
EMTREE MEDICAL INDEX TERMS
  endotracheal intubation (adverse drug reaction); human; intermittent positive pressure ventilation; methodology; psychological aspect; quality of life; review; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  1960533 (http://www.ncbi.nlm.nih.gov/pubmed/1960533)
PUI
  L22868793
DOI
  10.1080/01952307.1991.11735849
FULL TEXT LINK
  http://dx.doi.org/10.1080/01952307.1991.11735849
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01952307&id=doi:10.1080%2F01952307.1991.11735849&atitle=Alternative+methods+of+ventilatory+support+for+the+patient+with+ventilatory+failure+due+to+spinal+cord+injury.&stitle=J+Am+Paraplegia+Soc&title=The+Journal+of+the+American+Paraplegia+Society&volume=14&issue=4&spage=158&epage=174&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=&isbn=&pages=158-174&date=1991&auinit1=J&auinitm=R
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1037
TITLE
  New approaches in the rehabilitation of the traumatic high level 
quadriplegic
AUTHOR NAMES
  Bach J.R.
AUTHOR ADDRESSES
  (Bach J.R.) Rehabilitation Medicine Dept., University Hospital, 150 Bergen 
Street, Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Rehabilitation Medicine Dept., University Hospital, 150 Bergen 
Street, Newark, NJ 07103, United States.
FULL RECORD ENTRY DATE
  1991-04-25
SOURCE
  American Journal of Physical Medicine and Rehabilitation (1991) 70:1 
(13-19). Date of Publication: 1991
VOLUME
  70
ISSUE
  1
FIRST PAGE
  13
LAST PAGE
  19
DATE OF PUBLICATION
  1991
ISSN
  0894-9115
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, United 
States.
ABSTRACT
  The use of noninvasive alternatives to tracheostomy for ventilatory support 
have been described in the patient management of various neuromuscular 
disorders. The use of these techniques for patients with traumatic high 
level quadriplegia, however, is hampered by the resort to tracheostomy in 
the acute hospital setting. Twenty traumatic high level quadriplegic 
patients on intermittent positive pressure ventilation (IPPV) via 
tracheostomy with little or no ability for unassisted breathing were 
converted to noninvasive ventilatory support methods and had their 
tracheostomy sites closed. Four additional patients were ventilated by 
noninvasive methods without tracheostomy. These methods included the use of 
body ventilators and the noninvasive intermittent positive airway pressure 
alternatives of IPPV via the mouth, nose, or custom acrylic strapless 
oral-nasal interface (SONI). Overnight end-tidal pCO(2) studies and 
monitoring of oxyhemoglobin saturation (SaO(2)) were used to adjust 
ventilator volumes and to document effective ventilation during sleep. No 
significant complications have resulted from the use of these methods over a 
period of 45 patient-years. Elimination of the tracheostomy permitted 
significant free time by glossopharyngeal breathing for four patients, two 
of whom had no measurable vital capacity. We conclude that noninvasive 
ventilatory support alternatives can be effective and deserve further study 
in this patient population.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia (rehabilitation); spinal cord injury (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; aged; clinical article; human; intermittent positive pressure ventilation; priority journal; review; tracheostomy; 
EMBASE CLASSIFICATIONS
  Physiology (2)
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1991117263
MEDLINE PMID
  1994965 (http://www.ncbi.nlm.nih.gov/pubmed/1994965)
PUI
  L21117262
DOI
  10.1097/00002060-199102000-00004
FULL TEXT LINK
  http://dx.doi.org/10.1097/00002060-199102000-00004
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=08949115&id=doi:10.1097%2F00002060-199102000-00004&atitle=New+approaches+in+the+rehabilitation+of+the+traumatic+high+level+quadriplegic&stitle=AM.+J.+PHYS.+MED.+REHABIL.&title=American+Journal+of+Physical+Medicine+and+Rehabilitation&volume=70&issue=1&spage=13&epage=19&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=AJPRE&isbn=&pages=13-19&date=1991&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1038
TITLE
  Noninvasive options for ventilatory support of the traumatic high level 
quadriplegic patient
AUTHOR NAMES
  Bach J.R.; Alba A.S.
AUTHOR ADDRESSES
  (Bach J.R.; Alba A.S.) Dept. Rehabilitation Medicine, University Hospital, 
Newark, NJ 07103, United States.
CORRESPONDENCE ADDRESS
  J.R. Bach, Dept. Rehabilitation Medicine, University Hospital, Newark, NJ 
07103, United States.
FULL RECORD ENTRY DATE
  1990-12-05
SOURCE
  Chest (1990) 98:3 (613-619). Date of Publication: 1990
VOLUME
  98
ISSUE
  3
FIRST PAGE
  613
LAST PAGE
  619
DATE OF PUBLICATION
  1990
ISSN
  0012-3692
BOOK PUBLISHER
  American College of Chest Physicians, 3300 Dundee Road, Northbrook, United 
States.
ABSTRACT
  The ventilation of 25 ventilator-dependent traumatic quadriplegic patients 
was supported by noninvasive means of ventilatory assistance. Twenty-four of 
the 25 were initially managed by endotracheal intubation, and 23 of these 
went on to tracheostomy intermittent positive pressure ventilation before 
being converted to NVA. Seventeen of the 23 patients had their 
tracheostomies closed. This included three patients with no significant free 
time except with the use of glossopharyngeal breathing. Seven of the 25 
patients who used NVA for at least one year with no significant free time 
have employed NVA for a mean of 7.4±7.4 years (1 to 22 years). Mouth IPPV 
was the most common form of NVA used both during the daytime and overnight. 
The wrap ventilators, intermittent abdominal pressure ventilator, and GPB 
were also employed for long-term respiratory support. It was concluded that, 
in general, because of their youth, intact mental status and bulbar 
musculature, and absence of obstructive lung disease, patients with 
traumatic high level spinal cord injury are candidates to benefit from these 
techniques.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  quadriplegia; 
EMTREE MEDICAL INDEX TERMS
  adult; article; assisted ventilation; endotracheal intubation; female; human; injury; major clinical study; male; methodology; priority journal; tracheostomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1990358601
MEDLINE PMID
  2203616 (http://www.ncbi.nlm.nih.gov/pubmed/2203616)
PUI
  L20352690
DOI
  10.1378/chest.98.3.613
FULL TEXT LINK
  http://dx.doi.org/10.1378/chest.98.3.613
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00123692&id=doi:10.1378%2Fchest.98.3.613&atitle=Noninvasive+options+for+ventilatory+support+of+the+traumatic+high+level+quadriplegic+patient&stitle=CHEST&title=Chest&volume=98&issue=3&spage=613&epage=619&aulast=Bach&aufirst=J.R.&auinit=J.R.&aufull=Bach+J.R.&coden=CHETB&isbn=&pages=613-619&date=1990&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1039
TITLE
  Patient in intensive care unit with traumatic medullar lesions. Evolution 
and complications
ORIGINAL (NON-ENGLISH) TITLE
  PACIENTE EN UCI CON LESION MEDULAR TRAUMATICA. EVOLUCION Y COMPLICACIONES
AUTHOR NAMES
  Castellote Olivito J.M.; Leon Valles M.; Cepero Moreno E.; Toribio Clemente L.J.; Trujillano Cabello J.; Campos Gutierrez E.
AUTHOR ADDRESSES
  (Castellote Olivito J.M.; Leon Valles M.; Cepero Moreno E.; Toribio Clemente 
L.J.; Trujillano Cabello J.; Campos Gutierrez E.) Sanitaria Miguel Servet, 
Zaragoza
CORRESPONDENCE ADDRESS
  Sanitaria Miguel Servet, Zaragoza
FULL RECORD ENTRY DATE
  1990-11-14
SOURCE
  Rehabilitacion (1990) 24:5 (311-314). Date of Publication: 1990
VOLUME
  24
ISSUE
  5
FIRST PAGE
  311
LAST PAGE
  314
DATE OF PUBLICATION
  1990
ISSN
  0048-7120
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; intensive care unit; lung complication; shock; spinal cord injury (therapy); tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  adult; article; clinical article; female; human; male; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
  Hematology (25)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1990328183
PUI
  L20322272
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00487120&id=doi:&atitle=Patient+in+intensive+care+unit+with+traumatic+medullar+lesions.+Evolution+and+complications&stitle=REHABILITACION&title=Rehabilitacion&volume=24&issue=5&spage=311&epage=314&aulast=Castellote+Olivito&aufirst=J.M.&auinit=J.M.&aufull=Castellote+Olivito+J.M.&coden=RHTNA&isbn=&pages=311-314&date=1990&auinit1=J&auinitm=M
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1040
TITLE
  Elective hypothermic cardiopulmonary bypass and circulatory arrest for 
spinal cord protection during operations on the thoracoabdominal aorta
AUTHOR NAMES
  Kouchoukos N.T.; Wareing T.H.; Izumoto H.; Klausing W.; Abboud N.
AUTHOR ADDRESSES
  (Kouchoukos N.T.; Wareing T.H.; Izumoto H.; Klausing W.; Abboud N.) Division 
of Cardiothoracic Surgery, Washington University School of Medicine, 216 S. 
Kingshighway Boulevard, St. Louis, MO 63110
CORRESPONDENCE ADDRESS
  N.T. Kouchoukos, Department of Surgery, Jewish Hospital, Washington 
University, 216 S. Kingshighway Blvd., St. Louis, MO 63110, United States.
FULL RECORD ENTRY DATE
  1990-06-11
SOURCE
  Journal of Thoracic and Cardiovascular Surgery (1990) 99:4 (659-664). Date 
of Publication: 1990
VOLUME
  99
ISSUE
  4
FIRST PAGE
  659
LAST PAGE
  664
DATE OF PUBLICATION
  1990
ISSN
  0022-5223
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  Resection of aneurysms of the entire descending thoracic aorta and segments 
of the abdominal aorta is associated with a substantial incidence of spinal 
cord ischemic injury, particularly in patients with aortic dissection. Since 
hypothermia has a protective effect on spinal cord function, we evaluated a 
technique of total cardiopulmonary bypass with periods of hypothermic 
circulatory arrest and low flow (rectal/bladder temperatures of 15° to 19°C) 
in five patients requiring replacement of the entire descending thoracic and 
the upper abdominal aorta and judged to be at high risk for the development 
of spinal cord injury. All patent lower intercostal and lumbar arteries were 
preserved or reimplanted during the hypothermic interval. There was one 
hospital death. None of the four survivors had a new spinal neurologic 
deficit, renal or cardiac dysfunction, or required reoperation for bleeding. 
Transfusion of blood was not excessive. Severe pulmonary dysfunction 
necessitating tracheostomy occurred in one patient and contributed to his 
death 7 weeks postoperatively. The remaining three patients are well 8 to 36 
months postoperatively. This initial experience suggests that hypothermic 
perfusion and circulatory arrest can be safely implemented in selected 
patients who require extensive aortic resections and who are at substantial 
risk for the development of spinal cord injury. Further evaluation of this 
technique is warranted.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal aorta; aortic surgery; cardiopulmonary bypass; spinal cord; thoracic aorta; 
EMTREE MEDICAL INDEX TERMS
  adult; aged; article; clinical article; human; hypothermia; priority journal; 
EMBASE CLASSIFICATIONS
  Internal Medicine (6)
  Neurology and Neurosurgery (8)
  Surgery (9)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1990146879
MEDLINE PMID
  2319787 (http://www.ncbi.nlm.nih.gov/pubmed/2319787)
PUI
  L20146534
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225223&id=doi:&atitle=Elective+hypothermic+cardiopulmonary+bypass+and+circulatory+arrest+for+spinal+cord+protection+during+operations+on+the+thoracoabdominal+aorta&stitle=J.+THORAC.+CARDIOVASC.+SURG.&title=Journal+of+Thoracic+and+Cardiovascular+Surgery&volume=99&issue=4&spage=659&epage=664&aulast=Kouchoukos&aufirst=N.T.&auinit=N.T.&aufull=Kouchoukos+N.T.&coden=JTCSA&isbn=&pages=659-664&date=1990&auinit1=N&auinitm=T
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1041
TITLE
  Oral intubation in the multiply injured patient: The risk of exacerbating 
spinal cord damage
AUTHOR NAMES
  Rhee K.J.; Green W.; Holcroft J.W.; Mangili J.A.A.
AUTHOR ADDRESSES
  (Rhee K.J.; Green W.; Holcroft J.W.; Mangili J.A.A.) Div. Emerg. 
Med./Trailer 1219, Univer. of California, Davis, Medical Center, 2315 
Stockton Boulevard, Sacramento, CA 95817, United States.
CORRESPONDENCE ADDRESS
  K.J. Rhee, Div. Emerg. Med./Trailer 1219, Univer. of California, Davis, 
Medical Center, 2315 Stockton Boulevard, Sacramento, CA 95817, United 
States.
FULL RECORD ENTRY DATE
  1990-06-05
SOURCE
  Annals of Emergency Medicine (1990) 19:5 (511-514). Date of Publication: 
1990
VOLUME
  19
ISSUE
  5
FIRST PAGE
  511
LAST PAGE
  514
DATE OF PUBLICATION
  1990
ISSN
  0196-0644
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  The use of oral intubation during the resuscitation of seriously injured 
patients has been discouraged because of the fear that this technique may 
lead to cervical cord damage. We report a retrospective study of the 
18-month experience of an emergeny department in which oral intubation was 
the usual method of airway control for victims of blunt trauma. There were 
237 injured patients intubated in the ED; 21 patients (8.9%) had cervical 
cord or bone injury. There were no patients in whom a neurologic loss 
followed an airway maneuver. Oral intubation was the definitive airway 
maneuver in 213 patients. There was no statistically significant difference 
in the type of definitive airway maneuver used (eg, oral intubation, nasal 
intubation, or cricothyrotomy-tracheotomy) between patients with cervical 
injuries and patients without such injuries. The risk of spinal cord injury 
secondary to oral intubation in the seriously injured patient was low in our 
population. Selection of the method for definitive airway control should be 
based primarily on the operator's skills and experience rather than the fear 
of inflicting cervical cord damage.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intubation; multiple trauma (therapy); resuscitation; spinal cord injury (complication); 
EMTREE MEDICAL INDEX TERMS
  adult; conference paper; human; major clinical study; priority journal; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Anesthesiology (24)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1990138414
MEDLINE PMID
  2331094 (http://www.ncbi.nlm.nih.gov/pubmed/2331094)
PUI
  L20138069
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01960644&id=doi:&atitle=Oral+intubation+in+the+multiply+injured+patient%3A+The+risk+of+exacerbating+spinal+cord+damage&stitle=ANN.+EMERG.+MED.&title=Annals+of+Emergency+Medicine&volume=19&issue=5&spage=511&epage=514&aulast=Rhee&aufirst=K.J.&auinit=K.J.&aufull=Rhee+K.J.&coden=AEMED&isbn=&pages=511-514&date=1990&auinit1=K&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1042
TITLE
  A rare and severe complication of meningeal hemorrhage: spinal arachnoiditis 
with paraplegia
ORIGINAL (NON-ENGLISH) TITLE
  Complication rare et grave de l'hémorragie méningée: arachnoidite dorsale 
avec paraplégie.
AUTHOR NAMES
  Jourdan C.; Artru F.; Convert J.; Ottolese C.; Chiara Y.; Naous H.; Tixier S.; Terrier A.
AUTHOR ADDRESSES
  (Jourdan C.; Artru F.; Convert J.; Ottolese C.; Chiara Y.; Naous H.; Tixier 
S.; Terrier A.) Service d'anesthésie et réanimation, Hôpital neurologique P. 
Wertheimer, Lyon.
CORRESPONDENCE ADDRESS
  C. Jourdan, Service d'anesthésie et réanimation, Hôpital neurologique P. 
Wertheimer, Lyon.
FULL RECORD ENTRY DATE
  1991-03-15
SOURCE
  Agressologie: revue internationale de physio-biologie et de pharmacologie 
appliquées aux effets de l'agression (1990) 31:6 (413-414). Date of 
Publication: Jun 1990
VOLUME
  31
ISSUE
  6
FIRST PAGE
  413
LAST PAGE
  414
DATE OF PUBLICATION
  Jun 1990
ISSN
  0002-1148
ABSTRACT
  This observation relates a case of spinal arachnoiditis with paraplegia, for 
a 56 year old patient hospitalized for a S.A.H. by a ruptured aneurysm of 
the P.I.C.A. This patient present some complications, requiring a prolonged 
ventilatory support with a tracheostomy, a ventricular shunt for 
hydrocephalus. The treatment is only surgical, and the corticosteroids delay 
the evolution, but without successful outcome.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  arachnoiditis (complication, etiology, surgery); subarachnoid hemorrhage (complication); 
EMTREE MEDICAL INDEX TERMS
  article; case report; female; human; laminectomy; middle aged; paraplegia (etiology); vertebra; 
LANGUAGE OF ARTICLE
  French
MEDLINE PMID
  2285117 (http://www.ncbi.nlm.nih.gov/pubmed/2285117)
PUI
  L21798593
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00021148&id=doi:&atitle=A+rare+and+severe+complication+of+meningeal+hemorrhage%3A+spinal+arachnoiditis+with+paraplegia&stitle=Agressologie&title=Agressologie%3A+revue+internationale+de+physio-biologie+et+de+pharmacologie+appliqu%C3%A9es+aux+effets+de+l%27agression&volume=31&issue=6&spage=413&epage=414&aulast=Jourdan&aufirst=C.&auinit=C.&aufull=Jourdan+C.&coden=&isbn=&pages=413-414&date=1990&auinit1=C&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1043
TITLE
  Prehospital cricothyrotomy: An investigation of indications, technique, 
complications, and patient outcome
AUTHOR NAMES
  Spaite D.W.; Joseph M.
AUTHOR ADDRESSES
  (Spaite D.W.; Joseph M.) Section Emergency Medicine, Arizona Health Sciences 
Center, 1501 North Campbell, Tucson, AZ 85724, United States.
CORRESPONDENCE ADDRESS
  D.W. Spaite, Section Emergency Medicine, Arizona Health Sciences Center, 
1501 North Campbell, Tucson, AZ 85724, United States.
FULL RECORD ENTRY DATE
  1990-04-01
SOURCE
  Annals of Emergency Medicine (1990) 19:3 (279-285). Date of Publication: 
1990
VOLUME
  19
ISSUE
  3
FIRST PAGE
  279
LAST PAGE
  285
DATE OF PUBLICATION
  1990
ISSN
  0196-0644
BOOK PUBLISHER
  Mosby Inc., 11830 Westline Industrial Drive, St. Louis, United States.
ABSTRACT
  The records of all patients who presented to a Level 1 trauma center during 
a two-year period for whom a prehospital cricothyrotomy was attempted or 
ordered were reviewed. Twenty patients met the study criteria. The average 
age was 37 years (range, 11 to 65 years). Indications for prehospital 
cricothyrotomy were massive facial trauma (eight), failed oral intubation 
(seven), and suspected cervical-spine injury (one). Cricothyrotomy was 
attempted in 16 patients (80%), with the remaining four having the procedure 
ordered but not attempted. A successful airway was achieved in 14 patients 
(88%). Horizontal incisions were used in all cases and were anatomically 
correct in 15 of 16 attempts (94%). The overall immediate complication rate 
was 31%. Two patients (12%) sustained major complications (failure to obtain 
an airway). No hemorrhagic complications occurred, but 16 of the 20 were in 
cardiac arrest in the field. Long-term complications were not evaluated. All 
patients sustained major injuries (mean Injury Severity Score, 53.7), except 
one patient who suffered airway obstruction from food. Three patients (15%) 
survived; two of the three suffered permanent, severe brain dysfunction. 
These preliminary findings demonstrate that prehospital cricothyrotomy is 
being used chiefly in massively injured patients who are already beyond 
recovery. It is thus difficult to assess whether the procedure is either 
safe or effective. There is a need for further investigation to determine 
whether prehospital cricothyrotomy has any beneficial effect on outcome and, 
if so, in what setting.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine injury; outpatient; 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; bleeding; female; heart arrest; human; major clinical study; male; methodology; organization and management; priority journal; school child; tracheotomy; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Public Health, Social Medicine and Epidemiology (17)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1990064799
MEDLINE PMID
  2310067 (http://www.ncbi.nlm.nih.gov/pubmed/2310067)
PUI
  L20064455
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01960644&id=doi:&atitle=Prehospital+cricothyrotomy%3A+An+investigation+of+indications%2C+technique%2C+complications%2C+and+patient+outcome&stitle=ANN.+EMERG.+MED.&title=Annals+of+Emergency+Medicine&volume=19&issue=3&spage=279&epage=285&aulast=Spaite&aufirst=D.W.&auinit=D.W.&aufull=Spaite+D.W.&coden=AEMED&isbn=&pages=279-285&date=1990&auinit1=D&auinitm=W
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1044
TITLE
  Spinal unit long term inpatient management of patients with severe 
neurological deficit
AUTHOR NAMES
  Griffiths E.R.
AUTHOR ADDRESSES
  (Griffiths E.R.) Spinal Department, Royal Perth Hospital, Shenton Park, WA 
6008
CORRESPONDENCE ADDRESS
  Spinal Department, Royal Perth Hospital, Shenton Park, WA 6008
FULL RECORD ENTRY DATE
  1989-11-10
SOURCE
  Paraplegia (1989) 27:5 (350-353). Date of Publication: 1989
VOLUME
  27
ISSUE
  5
FIRST PAGE
  350
LAST PAGE
  353
DATE OF PUBLICATION
  1989
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Patients with the 'locked-in syndrome' are now being presented to spinal 
units for long term care. This is becoming a problem in spinal cord injury 
units, which have developed to accept spinal cord injury in the acute stage, 
to manage problems resulting from this, and to conduct a rehabilitation 
programme. A case history is presented of a patient with Guillain-Barre's 
recurrent syndrome, already 3 years an inpatient in a spinal unit and with 
minimal recovery. Problems in care are described in a patient with total 
bulbar palsy, paralysis of the intercostal and of the diaphragm includes 
inability to swallow due to bulbar paralysis with nutrition delivered by 
jejunostomy. The presence of a tracheostomy, as well as the bulbar and 
laryngeal palsy, render vocal communication impossible. Total care has been 
provided in a spinal unit for the past 3 years, with no complications during 
his management. Given continuation of expert care, life expectancy may be 
that of many years. Is a spinal cord injury unit the proper place for long 
term management of cases of this nature and many similar cases described as 
having the 'locked-in syndrome'?
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Guillain Barre syndrome (rehabilitation); jejunostomy; locked in syndrome (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adult; case report; human; male; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1989254563
MEDLINE PMID
  2513547 (http://www.ncbi.nlm.nih.gov/pubmed/2513547)
PUI
  L19254517
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Spinal+unit+long+term+inpatient+management+of+patients+with+severe+neurological+deficit&stitle=PARAPLEGIA&title=Paraplegia&volume=27&issue=5&spage=350&epage=353&aulast=Griffiths&aufirst=E.R.&auinit=E.R.&aufull=Griffiths+E.R.&coden=PRPLB&isbn=&pages=350-353&date=1989&auinit1=E&auinitm=R
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1045
TITLE
  Minitracheotomy in the early respiratory management of patients with spinal 
injuries
AUTHOR NAMES
  Gupta A.; McClelland M.R.; Evans A.; El Masri W.S.
AUTHOR ADDRESSES
  (Gupta A.; McClelland M.R.; Evans A.; El Masri W.S.) Orthopaedic Registrar, 
University Department of Orthopaedics, Royal Liverpool Hospital, Liverpool
CORRESPONDENCE ADDRESS
  Orthopaedic Registrar, University Department of Orthopaedics, Royal 
Liverpool Hospital, Liverpool
FULL RECORD ENTRY DATE
  1989-09-05
SOURCE
  Paraplegia (1989) 27:4 (269-277). Date of Publication: 1989
VOLUME
  27
ISSUE
  4
FIRST PAGE
  269
LAST PAGE
  277
DATE OF PUBLICATION
  1989
ISSN
  0031-1758
BOOK PUBLISHER
  Nature Publishing Group, Houndmills, Basingstoke, Hampshire, United Kingdom.
ABSTRACT
  Minitracheotomy is a new technique of tracheal suction by the introduction 
under local anaesthetic of a small bore tube into the trachea through the 
cricothyroid membrane. The use of minitracheotomy in the early management of 
respiratory problems in patients with spinal injuries is described with a 
few illustrative cases. This technique is an adjunct to good physiotherapy 
in clearing secretions from the trachea. Its advantages and disadvantages 
are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  adult; human; major clinical study; methodology; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
  Otorhinolaryngology (11)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1989200172
MEDLINE PMID
  2780082 (http://www.ncbi.nlm.nih.gov/pubmed/2780082)
PUI
  L19200130
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Minitracheotomy+in+the+early+respiratory+management+of+patients+with+spinal+injuries&stitle=PARAPLEGIA&title=Paraplegia&volume=27&issue=4&spage=269&epage=277&aulast=Gupta&aufirst=A.&auinit=A.&aufull=Gupta+A.&coden=PRPLB&isbn=&pages=269-277&date=1989&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1046
TITLE
  Diaphragm pacing
AUTHOR NAMES
  Moxham J.; Potter D.
AUTHOR ADDRESSES
  (Moxham J.; Potter D.) Department of Thoracic Medicine, King's College 
Hospital, London SE5 8RX
CORRESPONDENCE ADDRESS
  Department of Thoracic Medicine, King's College Hospital, London SE5 8RX
FULL RECORD ENTRY DATE
  1988-05-04
SOURCE
  Thorax (1988) 43:3 (161-162). Date of Publication: 1988
VOLUME
  43
ISSUE
  3
FIRST PAGE
  161
LAST PAGE
  162
DATE OF PUBLICATION
  1988
ISSN
  0040-6376
BOOK PUBLISHER
  BMJ Publishing Group, Tavistock Square, London, United Kingdom.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; 
EMTREE MEDICAL INDEX TERMS
  editorial; human; hypoventilation; methodology; phrenic nerve pacing; priority journal; spinal cord injury; therapy; tracheotomy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1988086538
MEDLINE PMID
  3261459 (http://www.ncbi.nlm.nih.gov/pubmed/3261459)
PUI
  L18086538
DOI
  10.1136/thx.43.3.161
FULL TEXT LINK
  http://dx.doi.org/10.1136/thx.43.3.161
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00406376&id=doi:10.1136%2Fthx.43.3.161&atitle=Diaphragm+pacing&stitle=THORAX&title=Thorax&volume=43&issue=3&spage=161&epage=162&aulast=Moxham&aufirst=J.&auinit=J.&aufull=Moxham+J.&coden=THORA&isbn=&pages=161-162&date=1988&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1047
TITLE
  CT digital radiography: Alternative technique for airway evaluation in 
physically disabled patients
AUTHOR NAMES
  Mandell G.A.; Harcke H.T.; Padman R.; Brunson G.; Delengowski R.
AUTHOR ADDRESSES
  (Mandell G.A.; Harcke H.T.; Padman R.; Brunson G.; Delengowski R.) 
Department of Medical Imaging, Alfred I. du Pont Institute, Wilmington, DE 
19899
CORRESPONDENCE ADDRESS
  Department of Medical Imaging, Alfred I. du Pont Institute, Wilmington, DE 
19899
FULL RECORD ENTRY DATE
  1988-01-30
SOURCE
  Pediatric Radiology (1987) 17:6 (505-508). Date of Publication: 1987
VOLUME
  17
ISSUE
  6
FIRST PAGE
  505
LAST PAGE
  508
DATE OF PUBLICATION
  1987
ISSN
  0301-0449
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
ABSTRACT
  Evaluation of the airway for the presence of granulation tissue prior to 
removal of a tracheostomy is essential to prevent sudden respiratory 
decompensation secondary to obstruction. Airway examination in a brain 
and/or spinal cord injured patient is especially difficult under 
fluoroscopy. The patient's lack of mobility results in poor visualization of 
the trachea, secondry to the overlying dense osseous components of the 
shoulders and thoracic cage. A CT localization view (digital view), which 
allows manipulation and magnification of the digital data in order to see 
the hidden airway and detect associated obstructing lesions, is proffered as 
an alternative technique to high KV, magnifiction technique. Thirteen 
examinations were performed satisfactorily in eleven patients examined by 
this technique with little expenditure of time, physical exertion, and 
irradiation. The sensitivity, specificty and accuracy of digital airway 
examination were 100%, 67% and 92% respectively with bronchoscopy used as 
the standard.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchus patency; computer assisted tomography; trachea granuloma; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  bronchoscopy; case report; clinical article; computer analysis; diagnosis; human; methodology; respiratory system; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Radiology (14)
  Anesthesiology (24)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1987225747
MEDLINE PMID
  3684366 (http://www.ncbi.nlm.nih.gov/pubmed/3684366)
PUI
  L17158247
DOI
  10.1007/BF02388293
FULL TEXT LINK
  http://dx.doi.org/10.1007/BF02388293
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03010449&id=doi:10.1007%2FBF02388293&atitle=CT+digital+radiography%3A+Alternative+technique+for+airway+evaluation+in+physically+disabled+patients&stitle=PEDIATR.+RADIOL.&title=Pediatric+Radiology&volume=17&issue=6&spage=505&epage=508&aulast=Mandell&aufirst=G.A.&auinit=G.A.&aufull=Mandell+G.A.&coden=PDRYA&isbn=&pages=505-508&date=1987&auinit1=G&auinitm=A
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1048
TITLE
  Diaphragm paralysis causing ventilatory failure in an adult with the rigid 
spine syndrome
AUTHOR NAMES
  Efthimiou J.; McLelland J.; Round J.; Gribbin H.R.; Loh L.; Spiro S.G.
AUTHOR ADDRESSES
  (Efthimiou J.; McLelland J.; Round J.; Gribbin H.R.; Loh L.; Spiro S.G.) 
National Hospital for Nervous Diseases, London
CORRESPONDENCE ADDRESS
  National Hospital for Nervous Diseases, London
FULL RECORD ENTRY DATE
  1988-02-18
SOURCE
  American Review of Respiratory Disease (1987) 136:6 (1483-1485). Date of 
Publication: 1987
VOLUME
  136
ISSUE
  6
FIRST PAGE
  1483
LAST PAGE
  1485
DATE OF PUBLICATION
  1987
ISSN
  0003-0805
BOOK PUBLISHER
  American Lung Association, 16 Broadway Fl 4, New York, United States.
ABSTRACT
  A syndrome consisting of a rigid spine and myopathy predominantly affecting 
proximal limb muscles has been previously described in children, and as with 
most neuromuscular disorders, the respiratory muscles appear to be affected 
only at an advanced stage in the disease. We describe an adult male with 
this syndrome who presented with ventilatory failure caused by severe 
respiratory muscle weakness and who demonstrated profound nocturnal arterial 
oxygen desaturation, particularly during rapid eye movement sleep. Treatment 
with negative pressure ventilation initially resulted in only modest 
improvements in symptoms, blood gas tensions, and nocturnal desaturation. 
The cause of this only partial improvement was upper airway obstruction 
provoked by the mode of ventilatory support used. After tracheostomy there 
was a dramatic and sustained improvement in symptoms and blood gas tensions 
and complete abolition of nocturnal arterial oxygen desaturation. This is 
the first report of an adult with the rigid spine syndrome presenting with 
ventilatory failure and cor pulmonale due to severe respiratory muscle 
weakness.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm paralysis (diagnosis); myopathy (etiology); respiratory failure (therapy); spine disease (etiology); 
EMTREE MEDICAL INDEX TERMS
  adult; case report; human; male; tracheostomy; 
EMBASE CLASSIFICATIONS
  General Pathology and Pathological Anatomy (5)
  Internal Medicine (6)
  Pediatrics and Pediatric Surgery (7)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1988030288
MEDLINE PMID
  3688652 (http://www.ncbi.nlm.nih.gov/pubmed/3688652)
PUI
  L18030288
DOI
  10.1164/ajrccm/136.6.1483
FULL TEXT LINK
  http://dx.doi.org/10.1164/ajrccm/136.6.1483
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00030805&id=doi:10.1164%2Fajrccm%2F136.6.1483&atitle=Diaphragm+paralysis+causing+ventilatory+failure+in+an+adult+with+the+rigid+spine+syndrome&stitle=AM.+REV.+RESPIR.+DIS.&title=American+Review+of+Respiratory+Disease&volume=136&issue=6&spage=1483&epage=1485&aulast=Efthimiou&aufirst=J.&auinit=J.&aufull=Efthimiou+J.&coden=ARDSB&isbn=&pages=1483-1485&date=1987&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1049
TITLE
  The choice to end life as a ventilator-dependent quadriplegic
AUTHOR NAMES
  Maynard F.M.; Muth A.S.
AUTHOR ADDRESSES
  (Maynard F.M.; Muth A.S.) Department of Physical Medicine and 
Rehabilitation, University of Michigan Medical Center, Ann Arbor, MI 
48109-0042
CORRESPONDENCE ADDRESS
  Department of Physical Medicine and Rehabilitation, University of Michigan 
Medical Center, Ann Arbor, MI 48109-0042
FULL RECORD ENTRY DATE
  1988-02-05
SOURCE
  Archives of Physical Medicine and Rehabilitation (1987) 68:12 (862-864). 
Date of Publication: 1987
VOLUME
  68
ISSUE
  12
FIRST PAGE
  862
LAST PAGE
  864
DATE OF PUBLICATION
  1987
ISSN
  0003-9993
BOOK PUBLISHER
  W.B. Saunders, Independence Square West, Philadelphia, United States.
ABSTRACT
  A 17-year-old male sustained a C5/6 fracture dislocation and complete C5 
quadriplegia in a diving accident. Three days later sensory and motor 
function deteriorated and he required mechanical ventilation. Surgical 
exploration found no cause and a fusion was done. Neurologic function 
stabilized after three weeks with a C1 sensory level, no neck movement, and 
slight weakness of the tongue. Patient and family were followed closely by 
the spinal cord injury rehabilitation team from onset of injury. The patient 
was transferred to the ventilator-dependent pediatric rehabilitation program 
after ten weeks. Bowel, bladder, skin, and nutritional management were 
stabilized and taught to his parents who remained with him constantly. 
Communication was achieved with a 'talking tracheostomy'. He learned to use 
'Sip-n-Puff' control for driving an electric wheelchair and for Morse code 
input to a computer. He was passive but cooperative during hospitalization. 
Eight months after injury he was discharged to his home, which had been 
modified to meet his needs. A computer word processor, environmental control 
unit, and modified van were obtained; nursing care was provided around the 
clock. The patient enrolled in a community college course. Soon after 
discharge he contacted an attorney to explore legal actions for ending his 
life, which he considered intolerable. After obtaining medical and 
psychiatric reports, a court order was issued, which established his legal 
competence and directed people taking care of him to follow his directions. 
A few weeks later, 25 months after his injury, he privately said goodbye to 
his family, asked to be disconnected from the ventilator, and died. Medical 
and legal issues raised by this case are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; ethics; euthanasia; interpersonal communication; law; quadriplegia (rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  adolescent; case report; human; legal aspect; male; priority journal; psychological aspect; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
  Rehabilitation and Physical Medicine (19)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1988018513
MEDLINE PMID
  3426387 (http://www.ncbi.nlm.nih.gov/pubmed/3426387)
PUI
  L18018513
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039993&id=doi:&atitle=The+choice+to+end+life+as+a+ventilator-dependent+quadriplegic&stitle=ARCH.+PHYS.+MED.+REHABIL.&title=Archives+of+Physical+Medicine+and+Rehabilitation&volume=68&issue=12&spage=862&epage=864&aulast=Maynard&aufirst=F.M.&auinit=F.M.&aufull=Maynard+F.M.&coden=APMHA&isbn=&pages=862-864&date=1987&auinit1=F&auinitm=M
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1050
TITLE
  Spinal epidural abscess--report of 5 cases
AUTHOR NAMES
  Tsuji N.; Igarashi S.; Koyama T.
AUTHOR ADDRESSES
  (Tsuji N.; Igarashi S.; Koyama T.) Department of Neurosurgery, Ohtsu 
Municipal Hospital, Shiga-ken, Japan.
CORRESPONDENCE ADDRESS
  N. Tsuji, Department of Neurosurgery, Ohtsu Municipal Hospital, Shiga-ken, 
Japan.
FULL RECORD ENTRY DATE
  1988-03-14
SOURCE
  No shinkei geka. Neurological surgery (1987) 15:10 (1079-1085). Date of 
Publication: Oct 1987
VOLUME
  15
ISSUE
  10
FIRST PAGE
  1079
LAST PAGE
  1085
DATE OF PUBLICATION
  Oct 1987
ISSN
  0301-2603
ABSTRACT
  We reported 5 patients with spinal epidural abscess. They were two men and 
three women. Their ages ranged from 48 to 56 years (mean, 53 years). In 
three out of 5 cases, the etiology was thought to be infection after lumbar 
discography, tracheostomy and lumber surgery. In the other two cases the 
etiology could not be determined. The abscess was located at cervical, 
thoracic and lumbar levels in 2, 1 and 2 cases, respectively. The interval 
between initial symptoms and operation was from 1 to 3 months. Purulent 
epidural collection was found in four cases at operation. Irrigation and 
drainage were sufficiently performed postoperatively in 4 cases. Antibiotic 
therapy had been continued for at least 8 weeks in every case. As 
demonstrated in the case 2, CT scan was very useful in determining the 
extension of the abscess and degree of the cord compression by the abscess. 
Also in the case 2, the epidural abscess extending from cervical canal to 
extracanalicular space was completely drained by applying draining tubes 
without laminectomy. The present results indicate that emergency laminectomy 
is not always necessary for the treatment of epidural abscess, especially in 
subacute or chronic cases.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abscess (etiology, surgery); spine disease (etiology, surgery); 
EMTREE MEDICAL INDEX TERMS
  article; case report; computer assisted tomography; epidural space; female; human; laminectomy; male; middle aged; radiography; wound drainage; 
LANGUAGE OF ARTICLE
  Japanese
MEDLINE PMID
  3431641 (http://www.ncbi.nlm.nih.gov/pubmed/3431641)
PUI
  L18699392
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03012603&id=doi:&atitle=Spinal+epidural+abscess--report+of+5+cases&stitle=No+Shinkei+Geka&title=No+shinkei+geka.+Neurological+surgery&volume=15&issue=10&spage=1079&epage=1085&aulast=Tsuji&aufirst=N.&auinit=N.&aufull=Tsuji+N.&coden=&isbn=&pages=1079-1085&date=1987&auinit1=N&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1051
TITLE
  Glottic and tracheal stenosis in spinal cord injured patients
AUTHOR NAMES
  Hsu S.; Dreisbach J.N.; Charlifue S.W.; English G.M.
AUTHOR ADDRESSES
  (Hsu S.; Dreisbach J.N.; Charlifue S.W.; English G.M.) Rocky Mountain 
Regional Spinal Cord Injury System, Craig Hospital and Swedish Medical 
Center, Englewood, CO 80110
CORRESPONDENCE ADDRESS
  Rocky Mountain Regional Spinal Cord Injury System, Craig Hospital and 
Swedish Medical Center, Englewood, CO 80110
FULL RECORD ENTRY DATE
  1987-09-23
SOURCE
  Paraplegia (1987) 25:2 (136-148). Date of Publication: 1987
VOLUME
  25
ISSUE
  2
FIRST PAGE
  136
LAST PAGE
  148
DATE OF PUBLICATION
  1987
ISSN
  0031-1758
ABSTRACT
  Between 1965 and 1985, 47 cases of glottic and/or tracheal stenosis were 
diagnosed at the Rocky Mountain Regional Spinal Cord Injury System. A 
retrospective review of medical records identified associated injuries, 
pulmonary and other medical complications in this patient population. 
Radiographic and endoscopic reviews utilised a grading system to classify 
the severity of stenosis. The clinical symptoms of stenosis were multiple, 
including dysphonia, aspiration, dysphagia, odynophagia, dyspnea and 
excessive secretions. The wide spectrum of treatment modalities included 
endoscopy with excision and/or dilation, general medical management, 
steroids, radiation therapy, intubation, stent insertion and surgical repair 
of the stenotic area. Outcome status was reviewed and suggestions provided 
for the early diagnosis and treatment of this potentially life-threatening 
condition.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  glottis stenosis; spinal cord injury; trachea stenosis; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; clinical article; diagnosis; etiology; human; injury; larynx; management; respiratory system; therapy; 
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1987179924
MEDLINE PMID
  3588009 (http://www.ncbi.nlm.nih.gov/pubmed/3588009)
PUI
  L17112424
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Glottic+and+tracheal+stenosis+in+spinal+cord+injured+patients&stitle=PARAPLEGIA&title=Paraplegia&volume=25&issue=2&spage=136&epage=148&aulast=Hsu&aufirst=S.&auinit=S.&aufull=Hsu+S.&coden=PRPLB&isbn=&pages=136-148&date=1987&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1052
TITLE
  Management of airway trauma. II: Combined injuries of the trachea and 
esophagus
AUTHOR NAMES
  Kelly J.P.; Webb W.R.; Moulder P.V.
AUTHOR ADDRESSES
  (Kelly J.P.; Webb W.R.; Moulder P.V.) Department of Surgery, Tulane 
University School of Medicine, New Orleans, LA
CORRESPONDENCE ADDRESS
  Department of Surgery, Tulane University School of Medicine, New Orleans, LA
FULL RECORD ENTRY DATE
  1987-04-12
SOURCE
  Annals of Thoracic Surgery (1987) 43:2 (160-163). Date of Publication: 1987
VOLUME
  43
ISSUE
  2
FIRST PAGE
  160
LAST PAGE
  163
DATE OF PUBLICATION
  1987
ISSN
  0003-4975
ABSTRACT
  Twenty-four consecutive patients with combined injuries of the trachea and 
esophagus were operated on at the Tulane University Hospital and the Charity 
Hospital of New Orleans between 1967 and 1983. Only 3 of the injuries 
resulted from blunt trauma, and 1 of these patients had a total transection 
of both the trachea and esophagus; the remaining injuries were due to 
penetrating trauma (20 gunshot wounds; 1 stab wound). The combined lesions 
involved the cervical region in 20 patients and the thoracic esophagus and 
trachea or bronchus in 4. All patients underwent bronchoscopy; in recent 
years all have had esophagoscopy, because our experience indicates that 
esophagrams, which patients also underwent, have a high rate (12.5%) of 
false negative results. Operative techniques included a two-layer closure of 
all esophageal injuries, closure of the trachea with non-absorbable 
monofilament suture, and transthoracic or cervical drainage. Muscle flaps 
were used for suture line reinforcement. Associated operative procedures 
included tracheostomy (5), laparotomy (4), vascular procedures (5), 
neurologic procedures (2), and close-tube thoracostomy (6). Five patients 
(21%) died in the perioperative period, 4 of 20 with combined cervical 
injuries, and 1 of the 4 with combined thoracic injuries. Deaths resulted 
from missed injuries to the esophagus (2 patients), a missed tracheal injury 
(1), associated vascular injury (1), and associated thoracoabdominal injury 
(1). Two patients experienced cervical esophageal suture line leaks, both of 
which sealed with conservative therapy. Clinical follow-up showed good 
results in 90% of the patients who survived. One patient had late neurologic 
sequela of the injury, including spinal cord trauma and recurrent nerve 
paralysis, and 1 had pharyngeal paralysis from extensive neurologic damage 
in the neck. No patient had esophageal or tracheal stenosis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  blunt trauma; thorax penetrating trauma; 
EMTREE MEDICAL INDEX TERMS
  bronchoscopy; clinical article; diagnosis; esophagoscopy; esophagus; human; injury; priority journal; respiratory system; therapy; thorax surgery; trachea; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
  Gastroenterology (48)
  Radiology (14)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1987085149
MEDLINE PMID
  3813705 (http://www.ncbi.nlm.nih.gov/pubmed/3813705)
PUI
  L17017649
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:&atitle=Management+of+airway+trauma.+II%3A+Combined+injuries+of+the+trachea+and+esophagus&stitle=ANN.+THORAC.+SURG.&title=Annals+of+Thoracic+Surgery&volume=43&issue=2&spage=160&epage=163&aulast=Kelly&aufirst=J.P.&auinit=J.P.&aufull=Kelly+J.P.&coden=ATHSA&isbn=&pages=160-163&date=1987&auinit1=J&auinitm=P
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1053
TITLE
  Postextubation airway obstruction after anesthesia for posterior fusion of 
occipital bone and cervical spine
AUTHOR NAMES
  Kainuma M.; Yamada S.
AUTHOR ADDRESSES
  (Kainuma M.; Yamada S.) Department of Anesthesiology, Nagoya University 
School of Medicine, Nagoya 466
CORRESPONDENCE ADDRESS
  Department of Anesthesiology, Nagoya University School of Medicine, Nagoya 
466
FULL RECORD ENTRY DATE
  1986-02-26
SOURCE
  Japanese Journal of Anesthesiology (1985) 34:11 (1525-1529). Date of 
Publication: 1985
VOLUME
  34
ISSUE
  11
FIRST PAGE
  1525
LAST PAGE
  1529
DATE OF PUBLICATION
  1985
ISSN
  0021-4892
ABSTRACT
  A 53-year old female suffering from atlanto-axial subluxation due to 
advanced rheumatoid arthritis was scheduled for posterior fusion of the 
occipital bone and cervical spine. The trachea was transnasally intubated 
with a spiral tube, using the fiber-optic bronchoscope because of being 
unable to open the mouth caused by temporo-mandibular joint ankylosis. under 
nitrous oxide-oxygen-enflurane anesthesia, the surgery was finished 
uneventfully after 8 hours, resulting in the spine completely fixed at the 
severe flexion position. After recognizing that she awoke by opening eyes 
and grasping hand following the anesthetist's orders, the trachea was 
extubated, without removing her Halo-vest. Although she could speak easily 
to the anesthetist just after extubation, her upper airway was rapidly 
obstructed, followed by general cyanosis and severe hypotension. Emergency 
tracheostomy was carried out maintaining her airway. This airway 
complication was considered to be attributed to the severe flexion fixation 
of the spine resulting from the surgery and wearing the Halo-vest, and the 
worsening of the already compromised cricoarytenoid joint by the stimulus of 
the fiber-optic bronchoscope.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway obstruction; cervical spine fusion; extubation; rheumatoid arthritis; 
EMTREE MEDICAL INDEX TERMS
  bone; case report; fiberoscope; human; joint; postoperative complication; priority journal; respiratory system; therapy; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Forensic Science Abstracts (49)
LANGUAGE OF ARTICLE
  Japanese
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1986033782
MEDLINE PMID
  4087349 (http://www.ncbi.nlm.nih.gov/pubmed/4087349)
PUI
  L16224721
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00214892&id=doi:&atitle=Postextubation+airway+obstruction+after+anesthesia+for+posterior+fusion+of+occipital+bone+and+cervical+spine&stitle=JPN.+J.+ANESTHESIOL.&title=Japanese+Journal+of+Anesthesiology&volume=34&issue=11&spage=1525&epage=1529&aulast=Kainuma&aufirst=M.&auinit=M.&aufull=Kainuma+M.&coden=MASUA&isbn=&pages=1525-1529&date=1985&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 1054
TITLE
  Odontoid upward migration in rheumatoid arthritis. An analysis of 45 
patients with 'cranial settling'
AUTHOR NAMES
  Menezes A.H.; VanGilder J.C.; Clark C.R.; El-Khoury G.
AUTHOR ADDRESSES
  (Menezes A.H.; VanGilder J.C.; Clark C.R.; El-Khoury G.) Division of 
Neurological Surgery and Department of Orthopaedics, University of Iowa, 
Hospitals and Clinics, Iowa City, IA 52242
CORRESPONDENCE ADDRESS
  Division of Neurological Surgery and Department of Orthopaedics, University 
of Iowa, Hospitals and Clinics, Iowa City, IA 52242
FULL RECORD ENTRY DATE
  1986-02-20
SOURCE
  Journal of Neurosurgery (1985) 63:4 (500-509). Date of Publication: 1985
VOLUME
  63
ISSUE
  4
FIRST PAGE
  500
LAST PAGE
  509
DATE OF PUBLICATION
  1985
ISSN
  0022-3085
ABSTRACT
  Lack of correlation between the severity of rheumatoid subluxation of the 
upper cervical vertebrae and supposed absence of neurological damage has led 
to erroneous supposition that this finding is innocuous. Incomplete autopsy 
studies in rheumatoid arthritis have failed to recognize the cause of death, 
despite previously proven dramatic occipito-atlanto-axial dislocations. The 
most feared entity of rheumatoid basilar invagination, namely 'cranial 
settling', is poorly understood. Between 1978 and 1984, the authors treated 
45 rheumatoid arthritis patients who were symptomatic with 'cranial 
settling'. This consisted of vertical odontoid penetration through the 
foramen magnum (9 to 33 mm), occipito-atlanto-axial dislocation, lateral 
atlantal mass erosion, downward telescoping of the anterior arch of C-1 on 
the axis, and rostral rotation of the posterior arch of C-1 producing 
ventral and dorsal cervicomedullary junction compromise. Cervicomedullary 
junction dysfunction has mistakenly been called 'entrapment neuropathy', 
'progression of disease' or 'vasculitis'. Occipital pain occurred in all 45 
patients, myelopathy in 36, blackout spells in 24, brain-stem signs in 17, 
and lower cranial nerve palsies in 10. Four patients had prior 
tracheostomies. Four previously asymptomatic patients with 'cranial 
settling' presented acutely quadriplegic. The factors governing treatment 
were reducibility and direction of encroachment determined by skeletal 
traction and myelotomography. Transoral odontoidectomy was performed in 
seven patients with irreducible pathology. All patients underwent 
occipitocervical bone fusion (with C-1 decompression if needed) and acrylic 
fixation. Improvement occurred during traction, implying that compression 
might be the etiology for the neurological signs. There were no 
complications. Thus, 'cranial settling' is a frequent complication of 
neurological signs. There were no complications. Thus, 'cranial settling' is 
a frequent complication of rheumatoid arthritis; although it is poorly 
recognized, it has serious implications and is treatable.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  basilar impression; brain stem compression; cervical myelopathy; odontoid process; rheumatoid arthritis; spinal cord compression; 
EMTREE MEDICAL INDEX TERMS
  bone; bone fusion; central nervous system; cervical spine; clinical article; cranial nerve paralysis; diagnosis; human; joint; myelography; occipital pain; peripheral nervous system; priority journal; spinal cord disease; therapy; tomography; tooth; traction therapy; vertebral artery compression; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
  Radiology (14)
  Arthritis and Rheumatism (31)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1986032726
MEDLINE PMID
  4032013 (http://www.ncbi.nlm.nih.gov/pubmed/4032013)
PUI
  L16223665
DOI
  10.3171/jns.1985.63.4.0500
FULL TEXT LINK
  http://dx.doi.org/10.3171/jns.1985.63.4.0500
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223085&id=doi:10.3171%2Fjns.1985.63.4.0500&atitle=Odontoid+upward+migration+in+rheumatoid+arthritis.+An+analysis+of+45+patients+with+%27cranial+settling%27&stitle=J.+NEUROSURG.&title=Journal+of+Neurosurgery&volume=63&issue=4&spage=500&epage=509&aulast=Menezes&aufirst=A.H.&auinit=A.H.&aufull=Menezes+A.H.&coden=JONSA&isbn=&pages=500-509&date=1985&auinit1=A&auinitm=H
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1055
TITLE
  Fracture of the cervical spine complicating bilateral fractures of the 
mandible: a case report.
AUTHOR NAMES
  Hemmings K.W.
AUTHOR ADDRESSES
  (Hemmings K.W.)
CORRESPONDENCE ADDRESS
  K.W. Hemmings,
FULL RECORD ENTRY DATE
  1985-11-04
SOURCE
  The British journal of oral & maxillofacial surgery (1985) 23:4 (279-283). 
Date of Publication: Aug 1985
VOLUME
  23
ISSUE
  4
FIRST PAGE
  279
LAST PAGE
  283
DATE OF PUBLICATION
  Aug 1985
ISSN
  0266-4356
ABSTRACT
  A case reported of a 21-year-old male who sustained a fracture of the body 
of the second cervical vertebra, a bilateral fracture of the mandible and a 
deep laceration on the left side of his neck. The importance of excluding 
cervical spine fractures in cases of severe trauma to the head and neck is 
emphasised, and the airway management problems are discussed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fracture (complication, therapy); mandible fracture (complication, therapy); second cervical vertebra; 
EMTREE MEDICAL INDEX TERMS
  adult; article; case report; fracture fixation; human; immobilization; injury; male; tracheotomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  2931107 (http://www.ncbi.nlm.nih.gov/pubmed/2931107)
PUI
  L15728238
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02664356&id=doi:&atitle=Fracture+of+the+cervical+spine+complicating+bilateral+fractures+of+the+mandible%3A+a+case+report.&stitle=Br+J+Oral+Maxillofac+Surg&title=The+British+journal+of+oral+%26+maxillofacial+surgery&volume=23&issue=4&spage=279&epage=283&aulast=Hemmings&aufirst=K.W.&auinit=K.W.&aufull=Hemmings+K.W.&coden=&isbn=&pages=279-283&date=1985&auinit1=K&auinitm=W
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1056
TITLE
  Atelectasis in spinal cord injured people after initial medical 
stabilization.
AUTHOR NAMES
  Sugarman B.
AUTHOR ADDRESSES
  (Sugarman B.)
CORRESPONDENCE ADDRESS
  B. Sugarman,
FULL RECORD ENTRY DATE
  1987-03-29
SOURCE
  The Journal of the American Paraplegia Society (1985) 8:3 (47-50). Date of 
Publication: Jul 1985
VOLUME
  8
ISSUE
  3
FIRST PAGE
  47
LAST PAGE
  50
DATE OF PUBLICATION
  Jul 1985
ISSN
  0195-2307
ABSTRACT
  Two hundred and forty-three spinal cord injured people were evaluated during 
271 consecutive admissions to a spinal cord injury service over four years. 
These patients all had received initial medical stabilization after spinal 
cord injury prior to admission. Atelectasis with or without apparent 
pulmonary infiltrate or pleural effusion was documented in six 
quadriplegics, all on the left side. Five out of the six had tracheostomies. 
Atelectasis occurred days to months after injury and initial medical 
stabilization. The patients often had symptoms and findings suggestive of 
other illnesses and may have had more invasive diagnostic and therapeutic 
procedures if the diagnosis of atelectasis was not provisionally made. 
Associated dyspnea delayed the rehabilitation of several patients. Response 
to vigorous pulmonary therapy and bronchoscopy, if necessary, was prompt, 
with complete resolution in less than 24 hours. The inability to clear 
secretions that caused this problem was responsible for recurrences in three 
patients. Preventive and therapeutic modalities such as assisted coughing, 
deep breathing, incentive spirometry, chest percussion, and suctioning, if 
necessary, should be practiced. Atelectasis may still occur after the 
original injury.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atelectasis (etiology, prevention); spinal cord injury (complication); 
EMTREE MEDICAL INDEX TERMS
  aged; article; case report; female; human; male; quadriplegia (etiology); thorax radiography; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  3842981 (http://www.ncbi.nlm.nih.gov/pubmed/3842981)
PUI
  L17696180
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01952307&id=doi:&atitle=Atelectasis+in+spinal+cord+injured+people+after+initial+medical+stabilization.&stitle=J+Am+Paraplegia+Soc&title=The+Journal+of+the+American+Paraplegia+Society&volume=8&issue=3&spage=47&epage=50&aulast=Sugarman&aufirst=B.&auinit=B.&aufull=Sugarman+B.&coden=&isbn=&pages=47-50&date=1985&auinit1=B&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1057
TITLE
  Respirator-dependent quadriplegics: problems during the weaning period.
AUTHOR NAMES
  Lamid S.; Ragalie G.F.; Welter K.
AUTHOR ADDRESSES
  (Lamid S.; Ragalie G.F.; Welter K.)
CORRESPONDENCE ADDRESS
  S. Lamid,
FULL RECORD ENTRY DATE
  1987-03-29
SOURCE
  The Journal of the American Paraplegia Society (1985) 8:2 (33-37). Date of 
Publication: Apr 1985
VOLUME
  8
ISSUE
  2
FIRST PAGE
  33
LAST PAGE
  37
DATE OF PUBLICATION
  Apr 1985
ISSN
  0195-2307
ABSTRACT
  During a two-year period we admitted 13 respirator-dependent quadriplegic 
patients to the spinal cord injury service at Wood VAMC for weaning from a 
mechanical ventilator, and rehabilitation. The patients were sent to the 
Spinal Cord Injury Center because initial weaning attempts from the 
respirator at other medical centers were unsuccessful. We successfully 
weaned them from the respirator, and at the time of discharge, only two 
patients required an indwelling tracheostomy tube for suction. The time 
required for weaning off the respirator varied from two days to 14 months. 
Most of the patients were discharged and many of them could independently 
perform the activities of daily living. We conclude that are four main 
factors which influence the successful weaning of dependent quadriplegics 
from the mechanical ventilator: alleviation of patient's anxiety and 
depression; family support; close working relationship between staff; 
prevention of complications such as pneumonia and urinary tract infections.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; quadriplegia (complication); respiratory failure (etiology, rehabilitation); 
EMTREE MEDICAL INDEX TERMS
  action potential; adult; anxiety; article; case report; female; human; injury; male; middle aged; phrenic nerve; psychological aspect; stimulation; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  3842980 (http://www.ncbi.nlm.nih.gov/pubmed/3842980)
PUI
  L17696178
DOI
  10.1080/01952307.1985.11785933
FULL TEXT LINK
  http://dx.doi.org/10.1080/01952307.1985.11785933
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01952307&id=doi:10.1080%2F01952307.1985.11785933&atitle=Respirator-dependent+quadriplegics%3A+problems+during+the+weaning+period.&stitle=J+Am+Paraplegia+Soc&title=The+Journal+of+the+American+Paraplegia+Society&volume=8&issue=2&spage=33&epage=37&aulast=Lamid&aufirst=S.&auinit=S.&aufull=Lamid+S.&coden=&isbn=&pages=33-37&date=1985&auinit1=S&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1058
TITLE
  Cefoperazone in the treatment of postsurgical wound infection, sepsis, and 
abscess of the spinal cord and brain
AUTHOR NAMES
  Jung Hyun Woo; Jae Kwang Ryu
AUTHOR ADDRESSES
  (Jung Hyun Woo; Jae Kwang Ryu) Department of Neurosurgery, Chonnam 
University Medical School Hospital, Kwangju
CORRESPONDENCE ADDRESS
  Department of Neurosurgery, Chonnam University Medical School Hospital, 
Kwangju
FULL RECORD ENTRY DATE
  1985-01-31
SOURCE
  Clinical Therapeutics (1984) 6:6 (839-843). Date of Publication: 1984
VOLUME
  6
ISSUE
  6
FIRST PAGE
  839
LAST PAGE
  843
DATE OF PUBLICATION
  1984
ISSN
  0149-2918
ABSTRACT
  Cefoperazone was used in the treatment of 23 cases of serious bacterial 
infection in 20 patients. Ten postoperative scalp wound infections, five 
infections at the site of tracheostomy, four cases of extradural spinal cord 
abscess, three cases of sepsis, and one abscess of the cerebellopontine 
angle were treated with cefoperazone (1 to 2 gm BID, usually for seven to 27 
days). There were excellent or good clinical responses in 87% (20/23) of the 
cases (14 of the 15 postsurgical wound infections, three of the four cases 
of spinal cord abscess, and all three cases of sepsis). Most of the 
organisms isolated from the patients' cultures were sensitive to 
cefoperazone. Excellent or good responses occurred in ten of the 12 
infections due to Staphylococcus aureus, in all three infections due to 
Pseudomonas sp, all three due to Citrobacter freundii, the two due to 
Serratia marcescens, one of the two due to Klebsiella sp, and the one due to 
Escherichia coli. Two patients with ventriculitis were clinically improved 
by three 1-gm infusions, via a shunt, of cefoperazone. No adverse effects of 
the antibiotic therapy were reported.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cefoperazone; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adverse drug reaction; bacterial infection; brain abscess; drug efficacy; drug therapy; postoperative infection; prophylaxis; sepsis; spinal cord abscess; wound infection; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; clinical article; human; intramuscular drug administration; intravenous drug administration; methodology; priority journal; therapy; 
CAS REGISTRY NUMBERS
  cefoperazone (62893-19-0, 62893-20-3)
EMBASE CLASSIFICATIONS
  Drug Literature Index (37)
  Neurology and Neurosurgery (8)
  Clinical and Experimental Pharmacology (30)
  Microbiology: Bacteriology, Mycology, Parasitology and Virology (4)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1985015756
MEDLINE PMID
  6509463 (http://www.ncbi.nlm.nih.gov/pubmed/6509463)
PUI
  L15215756
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=01492918&id=doi:&atitle=Cefoperazone+in+the+treatment+of+postsurgical+wound+infection%2C+sepsis%2C+and+abscess+of+the+spinal+cord+and+brain&stitle=CLIN.+THER.&title=Clinical+Therapeutics&volume=6&issue=6&spage=839&epage=843&aulast=Jung+Hyun+Woo&aufirst=&auinit=&aufull=Jung+Hyun+Woo&coden=CLTHD&isbn=&pages=839-843&date=1984&auinit1=&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1059
TITLE
  Microscopic decompression of the anterior upper cervical spine: A case of 
odontoid malunion to the atlas
AUTHOR NAMES
  Miller J.; Parent A.D.
AUTHOR ADDRESSES
  (Miller J.; Parent A.D.) Department of Neurosurgery, University of 
Mississippi, Jackson, MS
CORRESPONDENCE ADDRESS
  Department of Neurosurgery, University of Mississippi, Jackson, MS
FULL RECORD ENTRY DATE
  1984-07-25
SOURCE
  Neurosurgery (1984) 14:5 (583-587). Date of Publication: 1984
VOLUME
  14
ISSUE
  5
FIRST PAGE
  583
LAST PAGE
  587
DATE OF PUBLICATION
  1984
ISSN
  0148-396X
ABSTRACT
  For the past 20 years, the transoral approach to the upper cervical spine 
has been utilized for odontoid fractures, the removal of an abnormal 
odontoid process, decompression of basilar impression, and biopsy or 
resection of nasopharyngeal or metastatic tumors. The effectiveness and 
safety of this procedure is well documented. Use of the surgical microscopic 
adds to the efficiency and safety of the procedure. We are reporting a case 
of fusion of the odontoid base to the anterior arch of the atlas. To our 
knowledge, this entity has not been described previously. The spinal cord 
was protected by an initial posterior fusion of C-1, C-2, followed in 10 
days by a tracheostomy and the transoral removal of the anterior C-1 arch 
and the abnormal dens. Because the medical history did not reveal a source 
of trauma, it is supposed that the patient had malunion of the odontoid 
process to C-2, with subsequent migration and fusion of the dens to the C-1 
arch.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; computer assisted tomography; first cervical vertebra; odontoid process; spinal cord compression; 
EMTREE MEDICAL INDEX TERMS
  bone; case report; central nervous system; computer analysis; diagnosis; human; therapy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  General Pathology and Pathological Anatomy (5)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1984134076
MEDLINE PMID
  6728167 (http://www.ncbi.nlm.nih.gov/pubmed/6728167)
PUI
  L14109128
DOI
  10.1227/00006123-198405000-00012
FULL TEXT LINK
  http://dx.doi.org/10.1227/00006123-198405000-00012
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0148396X&id=doi:10.1227%2F00006123-198405000-00012&atitle=Microscopic+decompression+of+the+anterior+upper+cervical+spine%3A+A+case+of+odontoid+malunion+to+the+atlas&stitle=NEUROSURGERY&title=Neurosurgery&volume=14&issue=5&spage=583&epage=587&aulast=Miller&aufirst=J.&auinit=J.&aufull=Miller+J.&coden=NRSRD&isbn=&pages=583-587&date=1984&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1060
TITLE
  Transoral operations for craniospinal malformations.
AUTHOR NAMES
  Gilsbach J.; Eggert H.R.
AUTHOR ADDRESSES
  (Gilsbach J.; Eggert H.R.)
CORRESPONDENCE ADDRESS
  J. Gilsbach,
FULL RECORD ENTRY DATE
  1984-06-18
SOURCE
  Neurosurgical review (1983) 6:4 (199-209). Date of Publication: 1983
VOLUME
  6
ISSUE
  4
FIRST PAGE
  199
LAST PAGE
  209
DATE OF PUBLICATION
  1983
ISSN
  0344-5607
ABSTRACT
  The transoral approach to the lower third of the clivus and to the ventral 
aspect of the upper cervical spine is used in craniospinal malformations 
with or without dislocation as well as in basilar aneurysms, ventrally 
situated cranio-spinal tumours, fractures of the odontoid process, and in 
rheumatoid arthritis compressing the spinal cord. In consideration of the 
literature and ten personal cases the indications and techniques of the 
transoral approach in craniospinal malformations are discussed. According to 
our own experiences and those of other authors it is possible to expose the 
lower clivus and the cervical spine down to C2 by a midline incision of the 
pharyngeal wall using a mouth retractor and oral intubation. Splitting of 
the soft palate or resection of the hard palate are not necessary, a 
tracheotomy should be performed only in exceptional cases. In congenital 
craniospinal malformations without dislocation or instability causing a 
ventral compression of the spinal cord, for instance by the odontoid 
process, the transoral decompression is preferable to dorsal decompressing 
operations. In cases of pure instability without any space-occupying lesion 
the transoral and posterior approach are possible in order to perform a 
fusion. The last one seems more advantageous in these cases. In craniospinal 
malformations with dislocation causing a ventral and dorsal narrowing of the 
spinal canal, apart from the decompression a stabilization has to be 
achieved. In these usually complex malformations individual treatment is 
necessary. According to the rare cases in the literature and to our own 
experience a primary anterior decompression, followed by a most careful 
posterior stabilization seems to produce the most favourable results.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone dysplasia (surgery); cervical spine; skull; 
EMTREE MEDICAL INDEX TERMS
  adult; article; atlantoaxial joint; basilar impression (surgery); congenital malformation; dislocation (surgery); female; human; Klippel Feil syndrome (surgery); male; middle aged; procedures; radiography; second cervical vertebra; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  6674837 (http://www.ncbi.nlm.nih.gov/pubmed/6674837)
PUI
  L14736493
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03445607&id=doi:&atitle=Transoral+operations+for+craniospinal+malformations.&stitle=Neurosurg+Rev&title=Neurosurgical+review&volume=6&issue=4&spage=199&epage=209&aulast=Gilsbach&aufirst=J.&auinit=J.&aufull=Gilsbach+J.&coden=&isbn=&pages=199-209&date=1983&auinit1=J&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1061
TITLE
  Respiratory complications of achondroplasia
AUTHOR NAMES
  Stokes D.C.; Phillips J.A.; Leonard C.O.
AUTHOR ADDRESSES
  (Stokes D.C.; Phillips J.A.; Leonard C.O.) Eudowood Pediatr. Pulm. Div., 
Johns Hopkins Hosp., Baltimore, MD 21205
CORRESPONDENCE ADDRESS
  Eudowood Pediatr. Pulm. Div., Johns Hopkins Hosp., Baltimore, MD 21205
FULL RECORD ENTRY DATE
  1983-06-01
SOURCE
  Journal of Pediatrics (1983) 102:4 (534-541). Date of Publication: 1983
VOLUME
  102
ISSUE
  4
FIRST PAGE
  534
LAST PAGE
  541
DATE OF PUBLICATION
  1983
ISSN
  0022-3476
ABSTRACT
  Nine patients with achondroplasia who were seen over a three-year period 
developed significant respiratory complications. Eight had sleep-disordered 
breathing, including obtructive sleep apnea in five, for which two required 
tracheostomy. Of the seven patients with significant hypoxemia, five had 
clinical evidence of cor pulmonale and recurrent pulmonary infiltrates. Two 
patients died, one with autopsy findings of compression of the medulla at 
the level of the foramen magnum and one with respiratory and cardiac 
failure. Appropriate therapy for our patients depended on recognition of the 
mechanisms that led to the respiratory complications, including (1) chest 
deformity, (2) upper airway obstruction and sleep-disordered breathing, (3) 
neurologic complications, and (4) coincidental chronic pulmonary conditions 
such as asthma.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  achondroplasia; breathing disorder; lung infiltrate; sleep disordered breathing; 
EMTREE MEDICAL INDEX TERMS
  asthma; bone; central nervous system; congenital disorder; diagnosis; etiology; heart; heart failure; human; hypoxemia; infant; major clinical study; newborn; respiratory system; spinal cord compression; thorax malformation; 
EMBASE CLASSIFICATIONS
  Pediatrics and Pediatric Surgery (7)
  Human Genetics (22)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1983125708
MEDLINE PMID
  6834188 (http://www.ncbi.nlm.nih.gov/pubmed/6834188)
PUI
  L13114858
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223476&id=doi:&atitle=Respiratory+complications+of+achondroplasia&stitle=J.+PEDIATR.&title=Journal+of+Pediatrics&volume=102&issue=4&spage=534&epage=541&aulast=Stokes&aufirst=D.C.&auinit=D.C.&aufull=Stokes+D.C.&coden=JOPDA&isbn=&pages=534-541&date=1983&auinit1=D&auinitm=C
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1062
TITLE
  Anaesthetic considerations in patients with muscular dystrophy undergoing 
spinal fusion and Harrington rod insertion
AUTHOR NAMES
  Milne B.; Rosales J.K.
AUTHOR ADDRESSES
  (Milne B.; Rosales J.K.) Dept. Anaesth., Montreal Child. Hosp., Montreal, 
Que. H3H 1P3
CORRESPONDENCE ADDRESS
  Dept. Anaesth., Montreal Child. Hosp., Montreal, Que. H3H 1P3
FULL RECORD ENTRY DATE
  1982-10-25
SOURCE
  Canadian Anaesthetists Society Journal (1982) 29:3 (250-254). Date of 
Publication: 1982
VOLUME
  29
ISSUE
  3
FIRST PAGE
  250
LAST PAGE
  254
DATE OF PUBLICATION
  1982
ISSN
  0008-2856
ABSTRACT
  Charts of nine patients with Duchenne and one with Becker's muscular 
dystrophy who had undergone spinal fusion and Harrington rod insertion for 
scoliosis were reviewed retrospectively. The mean age was 15 years and mean 
angle of scoliosis was 69 degrees. Preoperative pulmonary function studies 
showed a restrictive defect with a mean vital capacity of 1.3 ± 0.69 litres, 
35 ± 20 per cent of predicted value, 33 ± 20 ml.kg(-1) and a mean 
inspiratory capacity of 0.99 ± 0.5 litres, 23 ± 13 ml/kg(-1). There were no 
anaesthetic complications during operation and obstructive cardiomyopathy, 
hyperpyrexia, hyperkalaemia and rhabdomyolysis were not problems. 
Succinylcholine was avoided. One patient developed an arrhythmia 
postoperatively and one patient whose postoperative problems included 
tracheostomy, pneumonia and sepsis could not be weaned from the ventilator 
and died 11 weeks after operation. As assessing risk and survival of the 
operation depends on objective pulmonary function, a vital capacity of at 
least 20 ml/kg(-1) in the range of 30 per cent of predicted volume with an 
inspiratory capacity of at least 15 ml/kg(-1) would appear to be adequate in 
patients with muscular dystrophy requiring Harrington rod insertion. Other 
factors including the rapidity of progression of the muscular disease, other 
respiratory and cardiovascular problems, and disease such as obesity should 
also be considered.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; lung function; muscular dystrophy; scoliosis; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  bone; case report; harrington technique; muscle; respiratory system; therapy; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Human Genetics (22)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  French
EMBASE ACCESSION NUMBER
  1982203259
MEDLINE PMID
  7074403 (http://www.ncbi.nlm.nih.gov/pubmed/7074403)
PUI
  L12055373
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00082856&id=doi:&atitle=Anaesthetic+considerations+in+patients+with+muscular+dystrophy+undergoing+spinal+fusion+and+Harrington+rod+insertion&stitle=CAN.+ANAESTH.+SOC.+J.&title=Canadian+Anaesthetists+Society+Journal&volume=29&issue=3&spage=250&epage=254&aulast=Milne&aufirst=B.&auinit=B.&aufull=Milne+B.&coden=CANJA&isbn=&pages=250-254&date=1982&auinit1=B&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1063
TITLE
  Respiratory problems encountered in appliance fitting, orthopedic correction 
and surgical treatment of trunk-muscle paralyses in children and adolescents
ORIGINAL (NON-ENGLISH) TITLE
  LES PROBLEMES RESPIRATOIRES RENCONTRES DANS L'APPAREILLAGE, LE REDRESSEMENT 
ORTHOPEDIQUE ET LE TRAITEMENT CHIRURGICAL DES TRONCS PARALYTIQUES, CHEZ 
L'ENFANT ET L'ADOLESCENT
AUTHOR NAMES
  Barois A.; Estournet B.; Harountunian A.; Adrien A.
AUTHOR ADDRESSES
  (Barois A.; Estournet B.; Harountunian A.; Adrien A.) Hop. Raymond Poincare, 
92380 Garches
CORRESPONDENCE ADDRESS
  Hop. Raymond Poincare, 92380 Garches
FULL RECORD ENTRY DATE
  1982-10-10
SOURCE
  Annales de Medecine Physique (1982) 25:1 (67-81). Date of Publication: 1982
VOLUME
  25
ISSUE
  1
FIRST PAGE
  67
LAST PAGE
  81
DATE OF PUBLICATION
  1982
ISSN
  0402-4621
ABSTRACT
  After birth the pulmonary alveoli multiply up to the age of 4 to 8 years, 
then they increase in size. The respiratory paralyses and the thoracic 
deformations that they entail have a repercussion on this pulmonary growth. 
Study of 66 children in whom the paralytic disease commenced before 4 years 
and some of whom were submitted to an intermittent or permanent artificial 
ventilation, enabled the authors to confirm the efficacy of pulmonary 
mobilisation to promote the alveolar growth. In a second part are specified 
the most appropriate ways of giving artificial ventilation in the paralytic 
respiratory insufficiency of the little child. The orthopedic correction and 
the surgical treatment of paralytic scolioses should avoid all impairment of 
the ventilatory function. Above all, vertebral arthrodesis should be 
followed by a systematic endotracheal ventilation for at least 8 days to 
avoid a considerable restriction of the immediate and later vital capacity 
which would run the risk of leading to a definitive tracheotomy for 
respiratory aid.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  lung ventilation; muscle disease; paralysis; poliomyelitis; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  adolescent; central nervous system; major clinical study; muscle; musculoskeletal system; nervous system; preschool child; respiratory system; school child; therapy; 
EMBASE CLASSIFICATIONS
  Rehabilitation and Physical Medicine (19)
  Orthopedic Surgery (33)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  French
EMBASE ACCESSION NUMBER
  1982190337
PUI
  L12042451
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=04024621&id=doi:&atitle=Respiratory+problems+encountered+in+appliance+fitting%2C+orthopedic+correction+and+surgical+treatment+of+trunk-muscle+paralyses+in+children+and+adolescents&stitle=ANN.+MED.+PHYS.&title=Annales+de+Medecine+Physique&volume=25&issue=1&spage=67&epage=81&aulast=Barois&aufirst=A.&auinit=A.&aufull=Barois+A.&coden=AMPHB&isbn=&pages=67-81&date=1982&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1064
TITLE
  A simplified alternative to orthogonal field overlap when irradiating a 
tracheostomy stoma or the hypopharynx
AUTHOR NAMES
  Pezner R.D.; Findley D.O.
AUTHOR ADDRESSES
  (Pezner R.D.; Findley D.O.) Div. Radiat. Oncol., City Hope Nat., Duarte., CA 
91010
CORRESPONDENCE ADDRESS
  Div. Radiat. Oncol., City Hope Nat., Duarte., CA 91010
FULL RECORD ENTRY DATE
  1982-01-15
SOURCE
  International Journal of Radiation Oncology Biology Physics (1981) 7:8 
(1121-1124). Date of Publication: 1981
VOLUME
  7
ISSUE
  8
FIRST PAGE
  1121
LAST PAGE
  1124
DATE OF PUBLICATION
  1981
ISSN
  0360-3016
ABSTRACT
  Orthogonal field arrangements are usually employed to irradiate a tumor 
volume which includes a tracheostomy stoma or the hypopharynx. This approach 
may produce a significantly greater dose than intended to a small segment of 
the cervical spinal cord because of filed overlap at depth from divergence 
of the beams. Various sophisticated approaches have been proposed to 
compensate for this overlap. All require marked precision in reproducing the 
fields on a daily basis. We propose a simplified approach of initially 
irradiating the entire treatment volume by anterior and posterior opposed 
fields. Opposed lateral fields that exclude the spinal cord would then 
provide local boost treatment. A case example and computer-generated isodose 
curves are presented.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypopharynx cancer; radiation field; radiotherapy; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  case report; larynx; methodology; pharynx; respiratory system; therapy; 
EMBASE CLASSIFICATIONS
  Radiology (14)
  Otorhinolaryngology (11)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1982010115
MEDLINE PMID
  7298404 (http://www.ncbi.nlm.nih.gov/pubmed/7298404)
PUI
  L12234164
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03603016&id=doi:&atitle=A+simplified+alternative+to+orthogonal+field+overlap+when+irradiating+a+tracheostomy+stoma+or+the+hypopharynx&stitle=INT.+J.+RADIAT.+ONCOL.+BIOL.+PHYS.&title=International+Journal+of+Radiation+Oncology+Biology+Physics&volume=7&issue=8&spage=1121&epage=1124&aulast=Pezner&aufirst=R.D.&auinit=R.D.&aufull=Pezner+R.D.&coden=IOBPD&isbn=&pages=1121-1124&date=1981&auinit1=R&auinitm=D
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1065
TITLE
  Associated injuries in patients with spinal injury
AUTHOR NAMES
  Silver J.R.; Morris W.R.; Otfinowski J.S.
AUTHOR ADDRESSES
  (Silver J.R.; Morris W.R.; Otfinowski J.S.) Nat. Spinal Injuries Cent., 
Stoke Mandeville Hosp., Aylesbury HP21 8AL
CORRESPONDENCE ADDRESS
  Nat. Spinal Injuries Cent., Stoke Mandeville Hosp., Aylesbury HP21 8AL
FULL RECORD ENTRY DATE
  1981-01-12
SOURCE
  Injury (1980) 12:3 (219-224). Date of Publication: 1980
VOLUME
  12
ISSUE
  3
FIRST PAGE
  219
LAST PAGE
  224
DATE OF PUBLICATION
  1980
ISSN
  0020-1383
ABSTRACT
  The associated injuries found in 100 consecutive spinal injuries are 
described. Fifty-one of the patients had injuries of the cervical cord, 31 
per cent complete. A total of 75 per cent of the patients had associated 
injuries, the commonest being a head injury. Chest injuries were the next 
most frequent. The management of these injuries in the presence of a severe 
spinal injury is described. The importance of early tracheostomy and 
prophylactic anticoagulant therapy is stressed in reducing the mortality to 
the order of 2 per cent. The value of spinal injury units is emphasized.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; spine injury; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; injury; major clinical study; musculoskeletal system; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Forensic Science Abstracts (49)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1981002694
MEDLINE PMID
  7228385 (http://www.ncbi.nlm.nih.gov/pubmed/7228385)
PUI
  L11226481
DOI
  10.1016/0020-1383(80)90011-X
FULL TEXT LINK
  http://dx.doi.org/10.1016/0020-1383(80)90011-X
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201383&id=doi:10.1016%2F0020-1383%2880%2990011-X&atitle=Associated+injuries+in+patients+with+spinal+injury&stitle=INJURY&title=Injury&volume=12&issue=3&spage=219&epage=224&aulast=Silver&aufirst=J.R.&auinit=J.R.&aufull=Silver+J.R.&coden=INJUB&isbn=&pages=219-224&date=1980&auinit1=J&auinitm=R
COPYRIGHT
  Copyright 2012 Elsevier B.V., All rights reserved.

RECORD 1066
TITLE
  Unilateral diaphragmatic paralysis in spinal cord injury patients
AUTHOR NAMES
  Carter R.E.
AUTHOR ADDRESSES
  (Carter R.E.) Rehab. Serv., Inst. Rehab. Res., Houston, Tex. 77030
CORRESPONDENCE ADDRESS
  Rehab. Serv., Inst. Rehab. Res., Houston, Tex. 77030
FULL RECORD ENTRY DATE
  1980-10-09
SOURCE
  Paraplegia (1980) 18:4 (267-273). Date of Publication: 1980
VOLUME
  18
ISSUE
  4
FIRST PAGE
  267
LAST PAGE
  273
DATE OF PUBLICATION
  1980
ISSN
  0031-1758
ABSTRACT
  Since the inception of the Spinal Cord Injury Center of The Institute for 
Rehabilitation and Research in 1961, over 1600 spinal cord injury patients 
have been admitted. Of these patients, approximately 51 per cent or 821 are 
tetraplegics. A review of the medical records shows that 22 patients had 
unilateral diaphragmatic paralysis. All but one of these patients are male, 
and they range in age from 15 to 73 years of age at onset. All cases with 
unilateral diaphragmatic paralysis are reviewed as to side of paralysis, 
incidence of tracheotomy, initial vital capacity, final vital capacity, and 
estimation as to the duration of diaphragmatic paralysis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diaphragm paralysis; spinal cord injury; tracheotomy; vital capacity; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; diaphragm; injury; major clinical study; muscle; paraplegia; quadriplegia; respiratory system; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Rehabilitation and Physical Medicine (19)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1980195190
MEDLINE PMID
  7422343 (http://www.ncbi.nlm.nih.gov/pubmed/7422343)
PUI
  L10036808
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Unilateral+diaphragmatic+paralysis+in+spinal+cord+injury+patients&stitle=PARAPLEGIA&title=Paraplegia&volume=18&issue=4&spage=267&epage=273&aulast=Carter&aufirst=R.E.&auinit=R.E.&aufull=Carter+R.E.&coden=PRPLB&isbn=&pages=267-273&date=1980&auinit1=R&auinitm=E
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1067
TITLE
  Neurogenic respiratory failure: A 5-year experience using implantable 
phrenic nerve stimulators
AUTHOR NAMES
  Oakes D.D.; Wilmot C.B.; Halverson D.; Hamilton R.D.
AUTHOR ADDRESSES
  (Oakes D.D.; Wilmot C.B.; Halverson D.; Hamilton R.D.) Dept. Surg., Santa 
Clara Valley Med. Cent., San Jose, Calif.
CORRESPONDENCE ADDRESS
  Dept. Surg., Santa Clara Valley Med. Cent., San Jose, Calif.
FULL RECORD ENTRY DATE
  1980-10-09
SOURCE
  Annals of Thoracic Surgery (1980) 30:2 (118-121). Date of Publication: 1980
VOLUME
  30
ISSUE
  2
FIRST PAGE
  118
LAST PAGE
  121
DATE OF PUBLICATION
  1980
ISSN
  0003-4975
ABSTRACT
  During the past 5 years, 20 phrenic nerve stimulators have been implanted in 
11 patients who were ventilator dependent because of neurogenic respiratory 
failure. Ten patients had traumatic spinal cord lesions; the remaining 
patient suffered from a progressive demyelinating disease. There was no 
operative mortality. Complications included 1 stimulator malfunction and 1 
pneumothorax. In spite of adjacent tracheostomies, there were no infections 
or wound complications. Of the 20 stimulators implanted, 13 initially 
produced good diaphragmatic function, 2 had fair function, and 5 had little 
or no function. Three patients became completely independent of their 
ventilators; 6 became partially independent, thus simplifying nursing care. 
There were no late complications. As of December 1979, 7 patients had 
benefited or were continuing to benefit from phrenic nerve stimulation.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neuromuscular disease; phrenic nerve pacing; respiratory failure; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; central nervous system; demyelinating neuropathy; diaphragm; major clinical study; methodology; nervous system; peripheral nervous system; respiratory system; spinal cord injury; therapy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1980195134
MEDLINE PMID
  6968185 (http://www.ncbi.nlm.nih.gov/pubmed/6968185)
PUI
  L10036752
DOI
  10.1016/S0003-4975(10)61226-X
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0003-4975(10)61226-X
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034975&id=doi:10.1016%2FS0003-4975%2810%2961226-X&atitle=Neurogenic+respiratory+failure%3A+A+5-year+experience+using+implantable+phrenic+nerve+stimulators&stitle=ANN.+THORAC.+SURG.&title=Annals+of+Thoracic+Surgery&volume=30&issue=2&spage=118&epage=121&aulast=Oakes&aufirst=D.D.&auinit=D.D.&aufull=Oakes+D.D.&coden=ATHSA&isbn=&pages=118-121&date=1980&auinit1=D&auinitm=D
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1068
TITLE
  Myelopathy in mucopolysaccharidosis type II (Hunter syndrome)
AUTHOR NAMES
  Ballenger C.E.; Swift T.R.; Leshner R.T.
AUTHOR ADDRESSES
  (Ballenger C.E.; Swift T.R.; Leshner R.T.) Dept. Neurol., Med. Coll. 
Georgia, Augusta, Ga.
CORRESPONDENCE ADDRESS
  Dept. Neurol., Med. Coll. Georgia, Augusta, Ga.
FULL RECORD ENTRY DATE
  1980-07-17
SOURCE
  Annals of Neurology (1980) 7:4 (382-385). Date of Publication: 1980
VOLUME
  7
ISSUE
  4
FIRST PAGE
  382
LAST PAGE
  385
DATE OF PUBLICATION
  1980
ISSN
  0364-5134
ABSTRACT
  A 24-year-old man with Hunter syndrome has spastic quadriparesis due to 
impingement of thickened meninges upon the cervical spinal cord. Tracheal 
narrowing due to submucosal deposits (presumably mucopolysaccharide) 
produced serious ventilatory complications during induction of anesthesia 
and necessitated tracheostomy before surgical decompression of the spinal 
cord could be attempted. Recognition of compressive myelopathy and tracheal 
compromise as late complications of Hunter syndrome may promote early 
therapy and prevent respiratory catastrophe.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Hunter syndrome; spastic tetraplegia; spinal cord disease; 
EMTREE MEDICAL INDEX TERMS
  case report; central nervous system; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Human Genetics (22)
  Clinical and Experimental Biochemistry (29)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1980145250
MEDLINE PMID
  6769383 (http://www.ncbi.nlm.nih.gov/pubmed/6769383)
PUI
  L10112836
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03645134&id=doi:&atitle=Myelopathy+in+mucopolysaccharidosis+type+II+%28Hunter+syndrome%29&stitle=ANN.+NEUROL.&title=Annals+of+Neurology&volume=7&issue=4&spage=382&epage=385&aulast=Ballenger&aufirst=C.E.&auinit=C.E.&aufull=Ballenger+C.E.&coden=ANNED&isbn=&pages=382-385&date=1980&auinit1=C&auinitm=E
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1069
TITLE
  Clinical study of injuries of the lower cervical spinal cord
AUTHOR NAMES
  Julow J.; Szarvas I.; Sarvary A.
AUTHOR ADDRESSES
  (Julow J.; Szarvas I.; Sarvary A.) Nat. Inst. Traumatol., Budapest
CORRESPONDENCE ADDRESS
  Nat. Inst. Traumatol., Budapest
FULL RECORD ENTRY DATE
  1979-12-10
SOURCE
  Injury (1979) 11:1 (39-42). Date of Publication: 1979
VOLUME
  11
ISSUE
  1
FIRST PAGE
  39
LAST PAGE
  42
DATE OF PUBLICATION
  1979
ISSN
  0020-1383
ABSTRACT
  The number of injuries of the spinal cord is increasing (from 9 to 24%). If 
there is a spinal block, a positive cisternal myelogram is recommended, as 
this is the only reliable procedure to indicate operation. The treatment is 
not uniform. Some authors prefer the conservative method; others perform 
laminectomy. 74% of deaths are due to respiratory complications. A 
prophylactic tracheostomy may reduce them. The prevention of blood clotting 
and urinary infection are no different from the well known methods. (Pap - 
Debrecen)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Brown Sequard syndrome; cervical spine; neck injury; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; injury; major clinical study; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1979245501
MEDLINE PMID
  521137 (http://www.ncbi.nlm.nih.gov/pubmed/521137)
PUI
  L9244026
DOI
  10.1016/S0020-1383(79)80123-0
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0020-1383(79)80123-0
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00201383&id=doi:10.1016%2FS0020-1383%2879%2980123-0&atitle=Clinical+study+of+injuries+of+the+lower+cervical+spinal+cord&stitle=INJURY&title=Injury&volume=11&issue=1&spage=39&epage=42&aulast=Julow&aufirst=J.&auinit=J.&aufull=Julow+J.&coden=INJUB&isbn=&pages=39-42&date=1979&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1070
TITLE
  Paraplegia and tetraplegia in spinal injuries
AUTHOR NAMES
  Lepisto P.; Harkonen M.; Paakkala T.
AUTHOR ADDRESSES
  (Lepisto P.; Harkonen M.; Paakkala T.) Inst. Clin. Sci., Univ. Tampere
CORRESPONDENCE ADDRESS
  Inst. Clin. Sci., Univ. Tampere
FULL RECORD ENTRY DATE
  1980-03-07
SOURCE
  Acta Orthopaedica Scandinavica (1979) 50:5 (602). Date of Publication: 1979
VOLUME
  50
ISSUE
  5
FIRST PAGE
  602
DATE OF PUBLICATION
  1979
ISSN
  0001-6470
ABSTRACT
  The series consisted of 29 patients operated on in 1968-75, 25 of whom were 
followed up until 1978. In 12 cases the indication for operation was severe 
radicular symptoms which did not respond to conservative treatment and which 
were connected with considerable degeneration of the corresponding spinal 
segment only. Seventeen patients were operated on for instability of the 
cervical spine caused by traumatic injury. The injury had been dislocation 
and radicular or medullary symptoms which persisted in spite of conservative 
treatment with skull traction or a collar. The late result was evaluated 
with a view to objective neurological improvement, subjective improvement, 
present symptoms and working capacity. All fusions were radiologically 
successful. The late result was fair or better in 7/11 in the degeneration 
group and in 12/14 in the traumatic injury group. An age of over 35 years 
and a preoperative motor defect were statistically significant factors for a 
poor prognosis in the traumatic injury group. Preoperative sick-leave and 
preoperative symptoms lasting over 6 months were prognostic factors for a 
poor result in the degeneration group.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; paraplegia; quadriplegia; spine; 
EMTREE MEDICAL INDEX TERMS
  case report; central nervous system; diagnosis; nervous system; respiratory system; therapy; thrombosis; tracheostomy; urinary tract infection; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1980055263
PUI
  L10211584
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00016470&id=doi:&atitle=Paraplegia+and+tetraplegia+in+spinal+injuries&stitle=ACTA+ORTHOP.+SCAND.&title=Acta+Orthopaedica+Scandinavica&volume=50&issue=5&spage=602&epage=&aulast=Lepisto&aufirst=P.&auinit=P.&aufull=Lepisto+P.&coden=AOSAA&isbn=&pages=602-&date=1979&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1071
TITLE
  Spinal cord injuries associated with vertebral fractures and dislocations. 
Clinical and radiological results in 30 patients
AUTHOR NAMES
  Harkonen M.; Lepisto P.; Paakkala T.
AUTHOR ADDRESSES
  (Harkonen M.; Lepisto P.; Paakkala T.) Inst. Clin. Sci., Univ. Tampere
CORRESPONDENCE ADDRESS
  Inst. Clin. Sci., Univ. Tampere
FULL RECORD ENTRY DATE
  1980-06-05
SOURCE
  Archives of Orthopaedic and Traumatic Surgery (1979) 94:3 (185-190). Date of 
Publication: 1979
VOLUME
  94
ISSUE
  3
FIRST PAGE
  185
LAST PAGE
  190
DATE OF PUBLICATION
  1979
ISSN
  0344-8444
ABSTRACT
  During the period 1968-1975, 11 patients with paraplegia and 19 with 
tetraplegia were treated at the Central Hospital of Tampere. The mean age of 
the patients was 33 years. The spinal cord injury was sustained in a traffic 
accident in 11 cases, at work in 6 and at home or during leisure hours in 
13. The injury was due to fall or to hitting the bottom in diving in 17 
cases. Reduction and osteosynthesis (Williams) were performed on 4 
paraplegic patients. The tetraplegics were treated by skull traction and an 
orthopedic brace. The average duration of primary hospital treatment was 69 
days for the paraplegics and 72 days for the tetraplegics. Tracheostomy was 
performed on 7 tetraplegic patients. Tracheal stricture, which developed in 
2 cases, was conservatively treated. A catheter a demeure was applied 
primarily in all cases, and urinary infection developed in all patients. 
Four paraplegics and 4 tetraplegics developed deep venous thrombosis, which 
led to pulmonary embolism in 1 paraplegic and 2 tetraplegic patients. All 
these patients recovered. During primary hospital treatment 3 paraplegics 
and 5 tetraplegics developed bed sores, which were operatively treated in 4 
cases. Two paraplegic and 8 tetraplegic patients died during primary 
hospital treatment; three of these patients had also sustained a severe 
brain injury. In addition, 1 paraplegic and 2 tetraplegic patients died of 
pulmonary infection during the five-year follow-up period. At the time of 
follow-up examination 7 paraplegics were nursed at home and 1 was in 
institutional care; the corresponding figures for the tetraplegics were 3 
and 6. Five of the paraplegics were ambulant in a wheel-chair, 2 walked with 
the aid of crutches, and 1 was a bed-patient. Of the tetraplegics, 6 were 
ambulant in a wheel-chair and 3 were nursed in bed. All surviving patients, 
1 paraplegic excepted, had a disability pension.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  paraplegia; quadriplegia; spinal cord injury; spine fracture dislocation; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; diagnosis; injury; major clinical study; musculoskeletal system; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Surgery (9)
  Rehabilitation and Physical Medicine (19)
  Neurology and Neurosurgery (8)
  Radiology (14)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  German
EMBASE ACCESSION NUMBER
  1980115383
MEDLINE PMID
  496589 (http://www.ncbi.nlm.nih.gov/pubmed/496589)
PUI
  L10146101
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03448444&id=doi:&atitle=Spinal+cord+injuries+associated+with+vertebral+fractures+and+dislocations.+Clinical+and+radiological+results+in+30+patients&stitle=ARCH.+ORTHOP.+TRAUM.+SURG.&title=Archives+of+Orthopaedic+and+Traumatic+Surgery&volume=94&issue=3&spage=185&epage=190&aulast=Harkonen&aufirst=M.&auinit=M.&aufull=Harkonen+M.&coden=AOUNA&isbn=&pages=185-190&date=1979&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1072
TITLE
  Acute respiratory insufficiency in traumatic tetraplegia
ORIGINAL (NON-ENGLISH) TITLE
  INSUFFICIENZA RESPIRATORIA ACUTA NELLA TETRAPLEGIA TRAUMATICA
AUTHOR NAMES
  Hachen H.J.
AUTHOR ADDRESSES
  (Hachen H.J.) Div. Med. Riab., Cent. Naz. Lesioni Spinali, Ist. Univ., 
Ginevra
CORRESPONDENCE ADDRESS
  Div. Med. Riab., Cent. Naz. Lesioni Spinali, Ist. Univ., Ginevra
FULL RECORD ENTRY DATE
  1979-10-02
SOURCE
  Minerva Anestesiologica (1979) 45:4 (227-232). Date of Publication: 1979
VOLUME
  45
ISSUE
  4
FIRST PAGE
  227
LAST PAGE
  232
DATE OF PUBLICATION
  1979
ISSN
  0375-9393
ABSTRACT
  The author reviews the case-histories of 188 patients with acute traumatic 
tetraplegia who were admitted to the National Spinal injuries Centre over 
the past 20 years. Since the introduction, in 1968, of a highly specialized, 
nation-wide helicopter rescue-system and the immediate transfer (within 1 
1/2 hours) of all polytraumatized patients to an intensive-care unit 
attached to the Paraplegic Centre, the mortality rate for complete 
tetraplegics (n = 117) has dropped from 32,5% in 1966 to 6,8% in 1976. For 
the 71 patients with incomplete lesions the numbers are 9,9% and 1,4% 
respectively. Most early deaths were found to be related to pulmonary 
complications. Due to paralysis of the thoracic muscles, the existence of 
severe hypoventilation and absence of the cough reflex, severe respiratory 
insufficiency may develop within a few hours after injury and this in the 
absence of any direct trauma to the chest. Tracheotomy had to be performed 
in 22,2% (= 26) of the patients with complete and in 5,6% (n = 4) of the 
ones with incomplete lesions. In 33,5% of all tetraplegics temporary 
nasotracheal intubation for periods of up to two weeks proved entirely 
sufficient. No complication arose from this procedure. On the other hand 4 
patients with tracheostomy developed severe local infection with resistant 
gram-negative germs, 2 showed posterior tracheomalacia, 1 was found to have 
distal tracheal stenosis and another one required surgical care for acute 
local hemorrhage. In view of this relatively high rate of complications 
(26,7%) 'prophylactic tracheostomy' does not seem advisable. Facilities for 
continuous monitoring of central venous pressure, arterial pressure, pulse 
rate, breathing pattern, pO(2), pCO(2), pH, electrolytes and blood and urine 
osmolality must be available for all patients with neurological levels above 
C6.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; quadriplegia; respiratory failure; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; major clinical study; respiratory system; therapy; 
EMBASE CLASSIFICATIONS
  Anesthesiology (24)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  Italian
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1979189792
MEDLINE PMID
  551339 (http://www.ncbi.nlm.nih.gov/pubmed/551339)
PUI
  L9189267
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03759393&id=doi:&atitle=Acute+respiratory+insufficiency+in+traumatic+tetraplegia&stitle=MINERVA+ANESTESIOL.&title=Minerva+Anestesiologica&volume=45&issue=4&spage=227&epage=232&aulast=Hachen&aufirst=H.J.&auinit=H.J.&aufull=Hachen+H.J.&coden=MIANA&isbn=&pages=227-232&date=1979&auinit1=H&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1073
TITLE
  The management of tumors of the upper cervical spine
AUTHOR NAMES
  Dunn E.J.; Anas P.P.
AUTHOR ADDRESSES
  (Dunn E.J.; Anas P.P.) Dept. Orthop. Surg., Univ. Massachusetts Med. Sch., 
Worcester, Mass.
CORRESPONDENCE ADDRESS
  Dept. Orthop. Surg., Univ. Massachusetts Med. Sch., Worcester, Mass.
FULL RECORD ENTRY DATE
  1979-04-03
SOURCE
  Orthopedic Clinics of North America (1978) 9:4 (1065-1080). Date of 
Publication: 1978
VOLUME
  9
ISSUE
  4
FIRST PAGE
  1065
LAST PAGE
  1080
DATE OF PUBLICATION
  1978
ISSN
  0030-5898
ABSTRACT
  Tumors of the atlas and axis are exceedingly uncommon lesions. A review of 
the literature provided 28 cases, of which two-thirds were the result of 
metastatic processes. Benign endoplasms in this region may cause serious 
sequelae resulting from impingement upon the lower brainstem, upper cervical 
cord, and vertebral arteries. Vigorous therapeutic endeavors should be 
undertaken with the aim of achieving complete amelioration of pain, reversal 
of neurologic impairment, and attainment of cervical stability. Although the 
underlying disease process in the majority of patients may be a terminal 
condition, improved longevity combined with the presence of disabling pain 
and neurologic compromise demands carefully planned treatment. Important 
points discussed include: It is necessary to establish tissue diagnosis by 
the appropriate method. The transpharyngeal needle biopsy of Ottolenghi is a 
safe and dependable method for obtaining tissue from the anterior elements 
of C1 and C2. Cord compression may result from two basic mechanisms, and it 
is necessary to resort to cervical myelography to distinguish between the 
two. Flexion and extension views, cineradiography, angiography, and 
tomography may assist in patient evaluation. Guidelines for planning the 
surgical approach are offered, as well as preferred exposure techniques. 
Anterior surgery in this region is a major undertaking and should be 
reserved for patients with benign anterior tumors or cancer patients with a 
good prognosis and specific indications. Tracheostomy should be carried out 
to avoid postoperative complications after anterior surgery. Whenever 
possible, bone grafting should be used to establish cervical fusion. Several 
drawbacks to succesful bone grafting exist in the case of metastatic 
disease. Some of these factors may be circumvented with the use of methyl 
methacrylate alone or in combination with a bone graft. Acrylic also allows 
early postoperative ambulation without the need for cumbersome external 
immobilization devices.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spine tumor; 
EMTREE MEDICAL INDEX TERMS
  bone; therapy; 
EMBASE CLASSIFICATIONS
  Cancer (16)
  Neurology and Neurosurgery (8)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1979063272
MEDLINE PMID
  740374 (http://www.ncbi.nlm.nih.gov/pubmed/740374)
PUI
  L9063090
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00305898&id=doi:&atitle=The+management+of+tumors+of+the+upper+cervical+spine&stitle=ORTHOP.+CLIN.+NORTH+AM.&title=Orthopedic+Clinics+of+North+America&volume=9&issue=4&spage=1065&epage=1080&aulast=Dunn&aufirst=E.J.&auinit=E.J.&aufull=Dunn+E.J.&coden=OCLNA&isbn=&pages=1065-1080&date=1978&auinit1=E&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1074
TITLE
  Vertebrectomy and fusion in the cervical spine
ORIGINAL (NON-ENGLISH) TITLE
  VERTEBREKTOMIE UND FUSION IM BEREICH DER HALSWIRBELSAULE
AUTHOR NAMES
  Karaguiosov L.; Andreeff I.
AUTHOR ADDRESSES
  (Karaguiosov L.; Andreeff I.) Wischnewastr. 9, 1126 Sofia
CORRESPONDENCE ADDRESS
  Wischnewastr. 9, 1126 Sofia
FULL RECORD ENTRY DATE
  1978-11-13
SOURCE
  Orthopadische Praxis (1978) 14:6 (415-419). Date of Publication: 1978
VOLUME
  14
ISSUE
  6
FIRST PAGE
  415
LAST PAGE
  419
DATE OF PUBLICATION
  1978
ISSN
  0030-588X
ABSTRACT
  Total replacements of cervical vertebrae are relatively rare and are 
occasionally indicated in tumors and inflammations, as this report of 8 
cases demonstrates. In case the third cervical vertebra is affected, the 
approach according to Stevenson is given preference to the transoral 
approach. Intubation necessitates, however, preoperative tracheotomy. For 
surgical interventions below the third cervical vertebra the ventral or 
ventrolateral approach is used. If the tumor has already affected the dorsal 
part of the cervical spine, bilateral operative treatment may become 
necessary.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bone resection; cervical spine; spine fusion; spondylodesis; vertebra; 
EMTREE MEDICAL INDEX TERMS
  bone; major clinical study; methodology; therapy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1978390718
PUI
  L8385658
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0030588X&id=doi:&atitle=Vertebrectomy+and+fusion+in+the+cervical+spine&stitle=ORTHOP.+PRAX.&title=Orthopadische+Praxis&volume=14&issue=6&spage=415&epage=419&aulast=Karaguiosov&aufirst=L.&auinit=L.&aufull=Karaguiosov+L.&coden=OPBAA&isbn=&pages=415-419&date=1978&auinit1=L&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1075
TITLE
  Intra medulla oblongata and cervical ependymoma (surgery, apnea for two 
months and improvement)
ORIGINAL (NON-ENGLISH) TITLE
  EPENDYMOME INTRA-BULBO-CERVICAL (ABLATION, APNEE DE 2 MOIS, GUERISON)
AUTHOR NAMES
  Banayan A.; Guerin J.; Boulard G.
AUTHOR ADDRESSES
  (Banayan A.; Guerin J.; Boulard G.) Clin. Neuro Chir. Cent. Jean Abadie, 
Bordeaux
CORRESPONDENCE ADDRESS
  Clin. Neuro Chir. Cent. Jean Abadie, Bordeaux
FULL RECORD ENTRY DATE
  1978-07-08
SOURCE
  Neurochirurgie (1978) 24:1 (67-69). Date of Publication: 1978
VOLUME
  24
ISSUE
  1
FIRST PAGE
  67
LAST PAGE
  69
DATE OF PUBLICATION
  1978
ISSN
  0028-3770
ABSTRACT
  A 17-year-old female was first seen in a neurology department in December 
1975. She was running a low grade fever; her general status was not good. At 
the physical examination she presented with an amyotrophy of both arms, 
mainly proximal, a thermo analgesic dissociation which was complete from C1 
to C5 and incomplete from C5 to D4, and a spastic quadriparesis (with a 
posterior spinal syndrome). The first physical disabilities had appeared 15 
months before. Myelography revealed an enlarged spinal cord in the upper 
part of the cervical region and the contrast media could not pass through 
the foramen magnum. At surgery a mass localized on the right side, inside 
the medulla oblongata and the spinal cord, with a cyst at each extremity, 
reaching C4 in the lower part and the recessus lateralis in the upper part. 
During surgery the patient was breathing spontaneously. After the removal of 
the mass, she presented with apnea. The quadriplegia following surgery was 
very brief. She rapidly recovered normal motor activity in both legs and in 
the right arm. Respiratory paralysis remained complete for 2 months. The 
right diaphragm recovered completely in 4 months, the left one only 
partially. 4 Months after surgery, she was discharged and returned home. One 
year later, to ensure security, she still has a tracheotomy. The distal 
paralysis of the left superior arm is still present.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  apnea; ependymoma; quadriplegia; spine surgery; 
EMTREE MEDICAL INDEX TERMS
  adolescent; case report; central nervous system; diagnosis; therapy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  General Pathology and Pathological Anatomy (5)
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  1978317708
MEDLINE PMID
  662067 (http://www.ncbi.nlm.nih.gov/pubmed/662067)
PUI
  L8314263
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00283770&id=doi:&atitle=Intra+medulla+oblongata+and+cervical+ependymoma+%28surgery%2C+apnea+for+two+months+and+improvement%29&stitle=NEUROCHIRURGIE&title=Neurochirurgie&volume=24&issue=1&spage=67&epage=69&aulast=Banayan&aufirst=A.&auinit=A.&aufull=Banayan+A.&coden=NUREB&isbn=&pages=67-69&date=1978&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1076
TITLE
  Stabilization of the collapsing spine in Duchenne muscular dystrophy
AUTHOR NAMES
  Sakai D.N.; Hsu J.D.; Bonnett C.A.; Brown J.C.
AUTHOR ADDRESSES
  (Sakai D.N.; Hsu J.D.; Bonnett C.A.; Brown J.C.) Div. Orthop. Surg., UCLA 
Sch. Med., Los Angeles, Calif. 90024
CORRESPONDENCE ADDRESS
  Div. Orthop. Surg., UCLA Sch. Med., Los Angeles, Calif. 90024
FULL RECORD ENTRY DATE
  1978-03-17
SOURCE
  Clinical Orthopaedics and Related Research (1977) No. 128 (256-260). Date of 
Publication: 1977
VOLUME
  No. 128
FIRST PAGE
  256
LAST PAGE
  260
DATE OF PUBLICATION
  1977
ISSN
  0009-921X
ABSTRACT
  Of 41 patients with Duchenne muscular dystrophy, no ambulatory patient had 
scoliosis greater than 19°. Non-ambulatory patients were prophylactically 
placed in body jackets, which kept the spine flexible and provided adequate 
support for sitting in the majority of patients. Ten patients had posterior 
spine fusion for progressive spinal collapse. The procedure was extensive 
with significant blood loss but bony fusion was achieved in every case. 
Pulmonary complications were minimized by performing preoperative 
tracheostomy on all patients who had vital capacities less than 40% and or 
non-functional coughs. Spinal fusion permitted long-term sitting stability 
despite the progression of the disease.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Duchenne muscular dystrophy; radiography; scoliosis; spine fusion; spine lesion; spine stabilization; 
EMTREE MEDICAL INDEX TERMS
  diagnosis; etiology; major clinical study; methodology; therapy; 
EMBASE CLASSIFICATIONS
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
  Radiology (14)
  Pediatrics and Pediatric Surgery (7)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1978255646
MEDLINE PMID
  340097 (http://www.ncbi.nlm.nih.gov/pubmed/340097)
PUI
  L8253157
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0009921X&id=doi:&atitle=Stabilization+of+the+collapsing+spine+in+Duchenne+muscular+dystrophy&stitle=CLIN.+ORTHOP.+RELAT.+RES.&title=Clinical+Orthopaedics+and+Related+Research&volume=No.+128&issue=&spage=256&epage=260&aulast=Sakai&aufirst=D.N.&auinit=D.N.&aufull=Sakai+D.N.&coden=CORTB&isbn=&pages=256-260&date=1977&auinit1=D&auinitm=N
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1077
TITLE
  Idealized care of the acutely injured spinal cord in Switzerland
AUTHOR NAMES
  Hachen H.J.
AUTHOR ADDRESSES
  (Hachen H.J.) Nat. Spinal Injuries Cent., Dept. Rehab. Med., Geneva Univ. 
Hosp., Geneva
CORRESPONDENCE ADDRESS
  Nat. Spinal Injuries Cent., Dept. Rehab. Med., Geneva Univ. Hosp., Geneva
FULL RECORD ENTRY DATE
  1978-03-28
SOURCE
  Journal of Trauma (1977) 17:12 (931-936). Date of Publication: 1977
VOLUME
  17
ISSUE
  12
FIRST PAGE
  931
LAST PAGE
  936
DATE OF PUBLICATION
  1977
ISSN
  0022-5282
ABSTRACT
  Case histories of 188 patients with acute traumatic tetraplegia who were 
admitted to the National Spinal Injuries Centre over the past 10 years are 
reviewed. Since the introduction, in 1968 of a highly specialized nationwide 
helicopter rescue system and the immediate transfer of all patients with 
multiple trauma to an intensive-care unit attached to the Paraplegic Centre, 
the mortality rate for complete tetraplegic (n = 117) has dropped from 32.5% 
(1966) to 6.8 (1976), and for the 71 patients with incomplete lesions from 
9.9% to 1.4%. Most early deaths were found to be related to pulmonary 
complications: paralysis of the thoracic muscles, severe hypoventilation, 
and absence of the cough reflex may lead to severe respiratory insufficiency 
within a few hours after injury even in the absence of any direct trauma to 
the chest. Tracheotomy had to be performed in 22.2% (n = 26) of our patients 
with complete and in 5.6% (n = 4) of those with incomplete lesions. In 33.5% 
of all tetraplegics temporary nasotracheal intubation for periods of up to 2 
weeks proved entirely sufficient with no complications. Four patients with 
tracheotomy developed severe local infection with resistant Gram-negative 
germs, two showed posterior tracheomalacia, one had distal tracheal 
stenosis, and one required surgical care for acute local hemorrhage. In view 
of this relatively high rate of complications (26.7%), 'prophylactic 
tracheotomy' does not seem advisable. Facilities for continuous monitoring 
of central venous pressure arterial pressure, pulse rates breathing pattern 
pO(2), pCO(2), pH, electrolytes, and blood and urine osmolality must be 
available for all patients with neurologic injuries above C6.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  intensive care; mortality; multiple trauma; nasotracheal intubation; quadriplegia; spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  central nervous system; injury; major clinical study; Switzerland; therapy; 
EMBASE CLASSIFICATIONS
  Public Health, Social Medicine and Epidemiology (17)
  Surgery (9)
  Orthopedic Surgery (33)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1978260648
MEDLINE PMID
  592441 (http://www.ncbi.nlm.nih.gov/pubmed/592441)
PUI
  L8258085
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00225282&id=doi:&atitle=Idealized+care+of+the+acutely+injured+spinal+cord+in+Switzerland&stitle=J.+TRAUMA&title=Journal+of+Trauma&volume=17&issue=12&spage=931&epage=936&aulast=Hachen&aufirst=H.J.&auinit=H.J.&aufull=Hachen+H.J.&coden=JOTRA&isbn=&pages=931-936&date=1977&auinit1=H&auinitm=J
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1078
TITLE
  Malignant astrocytoma of the pons and left cerebral peduncle: report of a 
case
AUTHOR NAMES
  Rosman *Roberson *Richardson Jr. N.P.G.H.E.P.
AUTHOR ADDRESSES
  (Rosman *Roberson *Richardson Jr. N.P.G.H.E.P.) Dept. Pediat. Neurol., 
Boston Univ. Sch. Med., Boston, Mass.
CORRESPONDENCE ADDRESS
  Dept. Pediat. Neurol., Boston Univ. Sch. Med., Boston, Mass.
FULL RECORD ENTRY DATE
  1977-07-25
SOURCE
  New England Journal of Medicine (1977) 296:15 (865-873). Date of 
Publication: 1977
VOLUME
  296
ISSUE
  15
FIRST PAGE
  865
LAST PAGE
  873
DATE OF PUBLICATION
  1977
ISSN
  0028-4793
ABSTRACT
  A 15-yr-old boy was admitted because of unresponsiveness and quadriparesis. 
2 wk after entry repeated neurologic examination revealed nystagmus in all 
directions of gaze. There was bilateral facial weakness, more marked on the 
left side; tongue movement was diminished; the left corneal reflex was 
absent, and the right decreased. The gag reflex was diminished. Right 
hemiparesis was still present, with increased right-sided reflexes. There 
were bilateral Babinski signs. Cerebellar ataxia was observed in the left 
upper extremity. 12 days before admission a tracheostomy had been performed. 
Spastic quadriplegia was present. The differential diagnosis is amply 
discussed because during life (he died on the 19th hospital day) there was 
no certainty in this reapect. The list of possibilities is a long one, but 
finally 2 diagnoses were suggested: acute multiple sclerosis (?) and pontine 
glioma (?), while the chief neurologist thought it to be a case of Leigh's 
disease (subacute necrotizing encephalomyelopathy). The post-mortem 
examination showed an infiltrating malignant tumor of the brainstem, located 
mainly in the pons, where it occupied the entire basal portion on the left 
side and much of it on the right; at the mid-pontine level it involved most 
of the tegmentum as well. The tumor extended upward into the midbrain, 
compressing and distorting it, although it was largely confined to the left 
cerebral peduncle. The cerebral hemispheres were otherwise intact, and the 
microscopical examination did not show diffuse infiltration of cerebral 
structures above the midbrain level. So the process was not cerebral 
gliomatosis. The neoplasm extended downward to the level of the junction 
between the pons and the medulla oblongata, with no evidence of tumor in the 
medulla itself or in the spinal cord. Sections of the brainstem revealed a 
malignant astrocytoma that permeated the fiber tracts and nuclei. In the 
fiber tracts the cells assumed an elongated bipolar configuration conforming 
to the polarity of the tracts. The tumor was anaplastic and there were large 
areas of coagulation necrosis. The tumor cells were undifferentiated, with 
hyperchromatic nuclei and scanty cytoplasm. In many fields there were tumor 
giant cells with large, irregular nuclei. Mitoses were numerous, and 
atypical and multipolar mitoses could be identified readily.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  astrocytoma; brain tumor; cerebellar ataxia; nystagmus; quadriplegia; 
EMTREE MEDICAL INDEX TERMS
  autopsy; child; diagnosis; histology; major clinical study; 
EMBASE CLASSIFICATIONS
  Cancer (16)
  General Pathology and Pathological Anatomy (5)
  Pediatrics and Pediatric Surgery (7)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1978074665
PUI
  L8074113
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00284793&id=doi:&atitle=Malignant+astrocytoma+of+the+pons+and+left+cerebral+peduncle%3A+report+of+a+case&stitle=NEW+ENGL.+J.+MED.&title=New+England+Journal+of+Medicine&volume=296&issue=15&spage=865&epage=873&aulast=Rosman+*Roberson+*Richardson+Jr.&aufirst=N.P.G.H.E.P.&auinit=N.P.G.H.E.P.&aufull=Rosman+*Roberson+*Richardson+Jr.+N.P.G.H.E.P.&coden=NEJMA&isbn=&pages=865-873&date=1977&auinit1=N&auinitm=P.G.H.E.P.
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1079
TITLE
  Management of craniocerebral trauma
ORIGINAL (NON-ENGLISH) TITLE
  CONDUITE A TENIR DEVANT UN TRAUMATISME CRANIO CEREBRAL
AUTHOR NAMES
  Lecuire J.; Bret Ph.
AUTHOR ADDRESSES
  (Lecuire J.; Bret Ph.) Serv. Neurochir., Hop. Neurol., Lyon
CORRESPONDENCE ADDRESS
  Serv. Neurochir., Hop. Neurol., Lyon
FULL RECORD ENTRY DATE
  1978-01-01
SOURCE
  Lyon Chirurgical (1976) 72:6 (439-441). Date of Publication: 1976
VOLUME
  72
ISSUE
  6
FIRST PAGE
  439
LAST PAGE
  441
DATE OF PUBLICATION
  1976
ISSN
  0024-7782
ABSTRACT
  In this short article the authors outline a plan for the management of 
severe craniocerebral injuries that begins at the scene of the injury. 
Initially the patient is to be protected from further injury. If he appears 
moribund or in severe vascular collapse, immediate life saving measures are 
required. Hemorrhage from large vessels must be controlled by compression 
bandages or even the application of hemostat forceps. In patients with 
multiple injuries, cardiovascular collapse may require intravenous fluid 
cortico steroids, vasopressors and revival of cardiac action. At the same 
time respiratory distress demands that an adequate airway be established by 
tracheal intubation, aspiration of the tracheal tube, oxygen therapy, 
assisted respiration and possibly tracheostomy. They admit that all of these 
measures at the scene of the injury imply the availability of necessary 
trained personnel and equipment in ambulances, helicopters and first aid 
posts. If associated spinal injuries are present special care in 
resuscitation measures and transportation are necessary. Transportation to a 
center for definitive treatment is essential within a maximum of three hours 
after injury. This should be possible in Europe except in unusual situations 
such as accidents in high altitudes, at night, or in bad weather. At 
admission to a hospital equipped for definitive treatment of injuries, the 
injured patient should be put in the care of a multidisciplinary team of 
anesthesiologists skilled in resuscitation techniques and general trauma, 
neurological and orthopedic surgeons. The clinical and neurological 
examination should be supported by radiological examinations, 
echoencephalography, electroencephalography and carotid angiography as 
required. The objective should be 1) continuous and complete surgical 
resuscitation, 2) performance of urgent surgery, and 3) the urgent 
neurosurgical procedures that are necessary. Some extracranial injuries take 
precedence over the craniocerebral trauma. They include ruptured viscera, 
major arteries, and some major extremity injuries. When neurosurgical 
intervention is required in the patient with multiple injuries, a competent 
experienced neuroanesthesiologist is necessary. Constant monitoring of the 
patient will indicate the necessity for angiography to determine whether an 
intracranial hematoma is present. Theoretically, within three days the 
patient can usually be transferred to a neurosurgical service. If assisted 
respiration is still necessary he will have to be in a semi intensive care 
unit of the neurosurgical service. As a rule highly specialized care will 
not be required for more than three weeks. Certain patients with continued 
deep coma or persistent unresponsiveness (vegetative state) will require 
continued neurosurgical care. After the patient has stabilized from his 
initial injury (usually in three days) other necessary extracranial injuries 
can be attended to. The authors further suggest that after three weeks of 
neurosurgical care, patients should be transferred to hospitals or centers 
that specialize in rehabilitation. Their care there should prepare them for 
return to their families and eventually to their previous social and 
economic status. This concise paper covers the subject well but the order of 
presentation is not as logical as it should be. It is still a valid plan for 
management of the severe craniocerebral injury with associated multiple 
injuries.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; head injury; 
EMTREE MEDICAL INDEX TERMS
  injury; therapy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  French
EMBASE ACCESSION NUMBER
  1978051526
PUI
  L8051044
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00247782&id=doi:&atitle=Management+of+craniocerebral+trauma&stitle=LYON+CHIR.&title=Lyon+Chirurgical&volume=72&issue=6&spage=439&epage=441&aulast=Lecuire&aufirst=J.&auinit=J.&aufull=Lecuire+J.&coden=LYCHA&isbn=&pages=439-441&date=1976&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1080
TITLE
  Critical notes on the transport of patients with cervical cord injuries
ORIGINAL (NON-ENGLISH) TITLE
  KRITISCHE ANMERKUNGEN ZUM TRANSPORT VON HALSMARKVERLETZTEN
AUTHOR NAMES
  Nechwatal E.
AUTHOR ADDRESSES
  (Nechwatal E.) Rehab. Zent. Tobelbad, Allg. Unfallversich. Anst., 
Tobelbad/Graz
CORRESPONDENCE ADDRESS
  Rehab. Zent. Tobelbad, Allg. Unfallversich. Anst., Tobelbad/Graz
FULL RECORD ENTRY DATE
  1976-01-01
SOURCE
  Chirurg (1975) 46:11 (521-523). Date of Publication: 1975
VOLUME
  46
ISSUE
  11
FIRST PAGE
  521
LAST PAGE
  523
DATE OF PUBLICATION
  1975
ISSN
  0009-4722
ABSTRACT
  Patients with a cervical spine injury who cannot be taken to a special 
centre immediately after the accident should be transferred to such a centre 
only when one is sure that no additional transportation trauma will be 
produced. The fractured cervical spine must be adequately stabilized during 
transportation. The partial oxygen pressure must not be lower than 60 mm Hg 
and one should wait at least 1 wk after removal of tracheostomy tube. An 
acute stress ulcer (melaena) also has to be excluded. 13 fatal cases are 
described.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  ambulance; cervical spine fracture; patient transport; spinal cord injury; stress ulcer; 
EMTREE MEDICAL INDEX TERMS
  injury; therapy; 
EMBASE CLASSIFICATIONS
  Surgery (9)
  Neurology and Neurosurgery (8)
  Public Health, Social Medicine and Epidemiology (17)
LANGUAGE OF ARTICLE
  German
EMBASE ACCESSION NUMBER
  1976188376
MEDLINE PMID
  1204394 (http://www.ncbi.nlm.nih.gov/pubmed/1204394)
PUI
  L6188295
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00094722&id=doi:&atitle=Critical+notes+on+the+transport+of+patients+with+cervical+cord+injuries&stitle=CHIRURG&title=Chirurg&volume=46&issue=11&spage=521&epage=523&aulast=Nechwatal&aufirst=E.&auinit=E.&aufull=Nechwatal+E.&coden=CHIRA&isbn=&pages=521-523&date=1975&auinit1=E&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1081
TITLE
  Severe injury to the neck region by seat belt
ORIGINAL (NON-ENGLISH) TITLE
  SCHWERE KOMBINATIONSVERLETZUNG DER HALSREGION DURCH SICHERHEITSGURT
AUTHOR NAMES
  Petersen H.; Lenz W.
AUTHOR ADDRESSES
  (Petersen H.; Lenz W.) Chir. Univ. Klin., Dusseldorf
CORRESPONDENCE ADDRESS
  Chir. Univ. Klin., Dusseldorf
FULL RECORD ENTRY DATE
  1976-01-01
SOURCE
  Aktuelle Traumatologie (1975) 5:4 (271-279). Date of Publication: 1975
VOLUME
  5
ISSUE
  4
FIRST PAGE
  271
LAST PAGE
  279
DATE OF PUBLICATION
  1975
ISSN
  0044-6173
ABSTRACT
  The problem of multiple injuries to the neck region by improper use of seat 
belts is discussed. The diagonal seat belt is an important factor in such 
injuries. Similar to whip lash injuries of the neck it results in 
hyperflexion fractures of the cervical spine, ruptures of the esophagus and 
trachea can be observed even without severe laceration to the skin, so that 
they are difficult to diagnose. Hemoptysis, mechanical airway obstruction 
and cervical emphysema are typical signs of damage of the upper airway. 
Difficulties in diagnosis are found with esophageal lacerations. Severe pain 
and dysphagy may point to it. The urgent problem is to clarify the 
lacerations by laryngo bronchoscopy, esophagoscopy and X ray examinations. 
The purpose of treatment is maintenance of free airway, early operative 
reconstruction, if possible, and sufficient immobilisation of cervical spine 
fractures.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchoscopy; carotid arteriography; cervical spine; emphysema; esophagoscopy; esophagus injury; injury; laryngoscopy; neck; neck injury; necrosis; radiodiagnosis; seatbelt injury; spine fracture; trachea injury; tracheitis; tracheoesophageal fistula; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  diagnosis; etiology; major clinical study; 
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Orthopedic Surgery (33)
  Neurology and Neurosurgery (8)
  Surgery (9)
LANGUAGE OF ARTICLE
  German
EMBASE ACCESSION NUMBER
  1976175683
PUI
  L6175610
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00446173&id=doi:&atitle=Severe+injury+to+the+neck+region+by+seat+belt&stitle=AKTUEL.+TRAUMATOL.&title=Aktuelle+Traumatologie&volume=5&issue=4&spage=271&epage=279&aulast=Petersen&aufirst=H.&auinit=H.&aufull=Petersen+H.&coden=AKTRA&isbn=&pages=271-279&date=1975&auinit1=H&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1082
TITLE
  Treatment of respiratory failure in cases of cervical spine injury
AUTHOR NAMES
  Cape J.; McAslan L.; Manson S.
AUTHOR ADDRESSES
  (Cape J.; McAslan L.; Manson S.) Sch. Phys. Occup. Ther., McGill Univ., 
Montreal
CORRESPONDENCE ADDRESS
  Sch. Phys. Occup. Ther., McGill Univ., Montreal
FULL RECORD ENTRY DATE
  1975-01-01
SOURCE
  Physiotherapy Canada (1974) 26:3 (133-141). Date of Publication: 1974
VOLUME
  26
ISSUE
  3
FIRST PAGE
  133
LAST PAGE
  141
DATE OF PUBLICATION
  1974
ISSN
  0300-0508
ABSTRACT
  The authors present a brief survey of the relevant information available on 
the external support system or adjuncts utilized in the acute treatment of 
patients in respiratory failure, as a result of traumatic injury to the 
cervical spine. The study is based on the contention that the 
physiotherapist, to contribute effectively to the total program, must become 
familiar with all equipment and treatment procedures essential to the life 
support techniques of the intensive care unit and the medical team.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; cervical spine; injury; intensive care; intermittent positive pressure ventilation; lung ventilation; respiratory failure; spinal cord transverse lesion; spine; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  therapy; 
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Rehabilitation and Physical Medicine (19)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1975068760
PUI
  L5068689
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03000508&id=doi:&atitle=Treatment+of+respiratory+failure+in+cases+of+cervical+spine+injury&stitle=PHYSIOTHER.+CAN.&title=Physiotherapy+Canada&volume=26&issue=3&spage=133&epage=141&aulast=Cape&aufirst=J.&auinit=J.&aufull=Cape+J.&coden=PTHCA&isbn=&pages=133-141&date=1974&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1083
TITLE
  Handbook of spinal medicine.
AUTHOR NAMES
  Burke D.C.; Murray D.D.
AUTHOR ADDRESSES
  (Burke D.C.; Murray D.D.)
CORRESPONDENCE ADDRESS
  D.C. Burke,
FULL RECORD ENTRY DATE
  1975-02-20
SOURCE
  The Australasian nurses journal (1974) 2:37 (9 contd). Date of Publication: 
Aug 1974
VOLUME
  2
ISSUE
  37
DATE OF PUBLICATION
  Aug 1974
ISSN
  0301-018X
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord disease (complication); 
EMTREE MEDICAL INDEX TERMS
  article; homeostasis; human; lung embolism (prevention); lymphedema (prevention); neurogenic bladder (rehabilitation); respiratory failure (therapy); thrombophlebitis (prevention); tracheotomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  4497751 (http://www.ncbi.nlm.nih.gov/pubmed/4497751)
PUI
  L5459510
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0301018X&id=doi:&atitle=Handbook+of+spinal+medicine.&stitle=Australas+Nurses+J&title=The+Australasian+nurses+journal&volume=2&issue=37&spage=&epage=&aulast=Burke&aufirst=D.C.&auinit=D.C.&aufull=Burke+D.C.&coden=&isbn=&pages=-&date=1974&auinit1=D&auinitm=C
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1084
TITLE
  Respiratory complications in traumatic quadriplegia. Analysis of 20 years' 
experience
AUTHOR NAMES
  Bellamy R.; Pitts F.W.; Stauffer E.S.
AUTHOR ADDRESSES
  (Bellamy R.; Pitts F.W.; Stauffer E.S.) Dept. Neurol. Surg., Univ. South. 
California Sch. Med., Los Angeles, Calif.
CORRESPONDENCE ADDRESS
  Dept. Neurol. Surg., Univ. South. California Sch. Med., Los Angeles, Calif.
FULL RECORD ENTRY DATE
  1974-01-01
SOURCE
  Journal of Neurosurgery (1973) 39:5 (596-600). Date of Publication: 1973
VOLUME
  39
ISSUE
  5
FIRST PAGE
  596
LAST PAGE
  600
DATE OF PUBLICATION
  1973
ISSN
  0022-3085
ABSTRACT
  A 20 year series of 531 patients with cervical spine fractures or 
dislocations is reviewed, and the records of 54 quadriplegic patients are 
analyzed in detail. Tracheostomy, surgery, overhydration, advanced age, 
severity of neurological injury, and corticosteroid therapy are discussed as 
factors in pulmonary complications.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing; lung edema; lung function; quadriplegia; spine fracture; tracheostomy; tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  injury; therapy; 
EMBASE CLASSIFICATIONS
  Neurology and Neurosurgery (8)
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Anesthesiology (24)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  1974112854
MEDLINE PMID
  4743566 (http://www.ncbi.nlm.nih.gov/pubmed/4743566)
PUI
  L4112777
DOI
  10.3171/jns.1973.39.5.0596
FULL TEXT LINK
  http://dx.doi.org/10.3171/jns.1973.39.5.0596
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00223085&id=doi:10.3171%2Fjns.1973.39.5.0596&atitle=Respiratory+complications+in+traumatic+quadriplegia.+Analysis+of+20+years%27+experience&stitle=J.+NEUROSURG.&title=Journal+of+Neurosurgery&volume=39&issue=5&spage=596&epage=600&aulast=Bellamy&aufirst=R.&auinit=R.&aufull=Bellamy+R.&coden=JONSA&isbn=&pages=596-600&date=1973&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2009 Elsevier B.V., All rights reserved.

RECORD 1085
TITLE
  The early management of cervical spin injuries.
AUTHOR NAMES
  McKibbin B.; Brotherton B.J.
AUTHOR ADDRESSES
  (McKibbin B.; Brotherton B.J.)
CORRESPONDENCE ADDRESS
  B. McKibbin,
FULL RECORD ENTRY DATE
  1974-10-06
SOURCE
  Resuscitation (1973) 2:4 (241-248). Date of Publication: Dec 1973
VOLUME
  2
ISSUE
  4
FIRST PAGE
  241
LAST PAGE
  248
DATE OF PUBLICATION
  Dec 1973
ISSN
  0300-9572
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; dislocation (therapy); fracture (therapy); spinal cord injury (etiology, therapy); spine injury (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  article; catheterization; human; injury; radiography; spinal cord compression (etiology); time; tracheotomy; traction therapy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  4793520 (http://www.ncbi.nlm.nih.gov/pubmed/4793520)
PUI
  L4534076
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03009572&id=doi:&atitle=The+early+management+of+cervical+spin+injuries.&stitle=Resuscitation&title=Resuscitation&volume=2&issue=4&spage=241&epage=248&aulast=McKibbin&aufirst=B.&auinit=B.&aufull=McKibbin+B.&coden=&isbn=&pages=241-248&date=1973&auinit1=B&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1086
TITLE
  The sensation produced by threshold resistive loads to breathing
AUTHOR NAMES
  Noble M.I.M.; Frankel H.L.; Else W.; Guz A.
AUTHOR ADDRESSES
  (Noble M.I.M.; Frankel H.L.; Else W.; Guz A.) Dept Med., Charing Cross Hosp. 
Med. Sch, London.
CORRESPONDENCE ADDRESS
  M.I.M. Noble, Dept Med., Charing Cross Hosp. Med. Sch, London.
FULL RECORD ENTRY DATE
  1972-12-01
SOURCE
  Eur.Clin.Invest. (Berl.) (1972) 2:2 (72-77). Date of Publication: 1972
VOLUME
  2
ISSUE
  2
FIRST PAGE
  72
LAST PAGE
  77
DATE OF PUBLICATION
  1972
ABSTRACT
  The ability to detect resistances added to the tracheostomy tubes of ENT 
patients was improved by allowing the pressure changes to be transmitted to 
the upper airways (by deflating the tracheostomy tube cuff). This suggests 
that the upper airways are sensitive detectors of added airway resistance 
and that this sensitivity masks impaired thoracic mechanisms of detection. 
Patients with chronic obstructive airways disease were able to detect added 
resistances less well than those with minimal airway disease. Patients with 
cervical cord transections from spinal level C3 to C6 were able to detect 
threshold resistive loads normally. It is concluded that receptors in the 
chest wall and diaphragm are not essential for the normal sensation of 
threshold resistive loads.
EMTREE DRUG INDEX TERMS
  receptor; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  breathing; sensation; 
EMTREE MEDICAL INDEX TERMS
  airway; airway resistance; cervical spinal cord; cuff; diaphragm; otorhinolaryngology; patient; respiratory tract disease; thorax wall; tracheostomy; tube; upper respiratory tract; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008667955
PUI
  L292103482
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=The+sensation+produced+by+threshold+resistive+loads+to+breathing&stitle=Eur.Clin.Invest.+%28Berl.%29&title=&volume=2&issue=2&spage=72&epage=77&aulast=Noble&aufirst=M.I.M.&auinit=M.I.M.&aufull=Noble+M.I.M.&coden=&isbn=&pages=72-77&date=1972&auinit1=M&auinitm=I.M.
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1087
TITLE
  Necrotizing encephalomyelopathy. report of a case with manifestations 
resembling behr's syndrome
AUTHOR NAMES
  Dunn H.G.; Dolman C.L.
AUTHOR ADDRESSES
  (Dunn H.G.; Dolman C.L.) Dept. Fed. Pathol., Univ. British Columbia, 
Vancouver.
CORRESPONDENCE ADDRESS
  H.G. Dunn, Dept. Fed. Pathol., Univ. British Columbia, Vancouver.
FULL RECORD ENTRY DATE
  1972-12-01
SOURCE
  Kur Neurol. (1972) 7:1-2 (97-112). Date of Publication: 1972
VOLUME
  7
ISSUE
  1-2
FIRST PAGE
  97
LAST PAGE
  112
DATE OF PUBLICATION
  1972
ABSTRACT
  A boy was first noted to have partial optic atrophy, strabismus, cerebellar 
ataxia and delayed behavioural development after the age of 4 yr. 
Subsequently he developed kyphosis and mild pes cavus; spasticity first 
became apparent in the legs, and a diagnosis of Behrs syndrome was 
entertained. However, the disease progressed in a series of relapses with 
subsequent partial recovery. At 12 1/2 yr he was shown to have bilateral 
depression of labyrinthine function attributable to a lesion of central 
vestibular pathways. He had high normal levels of blood Iactate and plasma 
alanine and somewhat high urinary alanine output. A diagnosis of necrotizing 
encephalomyelopathy was made and was confirmed when the urine was shown to 
inhibit thiamine pyrophosphate adenosine triphosphate phosphotransferase. 
During a further relapse with increased weakness impaired conduction in limb 
nerves was demonstrated. After slight improvement the boys condition 
deteriorated and he required respirator care and tracheostomy. I.v. infusion 
of thiamine hydrochloride and thiamine propyl disulphide (15 mg/kg daily) 
failed to arrest the downward course. He died at 12 yr 10 1/2 mth. Autopsy 
showed the characteristic changes of Leigh s disease which involved not only 
diencephalun and brain stem but also the optic nerves and chiasm, 
cerebellum, and cervical and thoracic portions of the spinal cord. The 
importance of considering necrotizing encephalomyelopathy in the 
differential diagnosis of hereditary ataxias in childhood is emphasized.L.
EMTREE DRUG INDEX TERMS
  adenosine triphosphate; alanine; cocarboxylase; phosphotransferase; propane; thiamine; 
EMTREE MEDICAL INDEX TERMS
  autopsy; blood; boy; brain stem; cerebellar ataxia; cerebellum; childhood; diagnosis; differential diagnosis; hereditary ataxia; infusion; kyphosis; leg; limb; male; nerve; optic nerve; optic nerve atrophy; plasma; relapse; seasonal variation; skin; spasticity; spinal cord; strabismus; tracheostomy; urine; ventilator; vestibular system; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008888242
PUI
  L292145039
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Necrotizing+encephalomyelopathy.+report+of+a+case+with+manifestations+resembling+behr%27s+syndrome&stitle=Kur+Neurol.&title=&volume=7&issue=1-2&spage=97&epage=112&aulast=Dunn&aufirst=H.G.&auinit=H.G.&aufull=Dunn+H.G.&coden=&isbn=&pages=97-112&date=1972&auinit1=H&auinitm=G
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1088
TITLE
  Osteomyelitis of the cervical spine after neck injuries.
AUTHOR NAMES
  Altman M.M.; Joachims H.Z.
AUTHOR ADDRESSES
  (Altman M.M.; Joachims H.Z.)
CORRESPONDENCE ADDRESS
  M.M. Altman,
FULL RECORD ENTRY DATE
  1972-08-08
SOURCE
  Archives of otolaryngology (Chicago, Ill. : 1960) (1972) 96:1 (72-75). Date 
of Publication: Jul 1972
VOLUME
  96
ISSUE
  1
FIRST PAGE
  72
LAST PAGE
  75
DATE OF PUBLICATION
  Jul 1972
ISSN
  0003-9977
EMTREE DRUG INDEX TERMS
  antiinfective agent (drug therapy); 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; neck injury; osteomyelitis (diagnosis, etiology, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; blast injury (complication); foreign body (complication); human; immobilization; male; myelography; radiography; tracheotomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  5032060 (http://www.ncbi.nlm.nih.gov/pubmed/5032060)
PUI
  L92447753
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039977&id=doi:&atitle=Osteomyelitis+of+the+cervical+spine+after+neck+injuries.&stitle=Arch+Otolaryngol&title=Archives+of+otolaryngology+%28Chicago%2C+Ill.+%3A+1960%29&volume=96&issue=1&spage=72&epage=75&aulast=Altman&aufirst=M.M.&auinit=M.M.&aufull=Altman+M.M.&coden=&isbn=&pages=72-75&date=1972&auinit1=M&auinitm=M
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1089
TITLE
  Major abdominal and thoracic trauma associated with spinal cord injury: 
problems in management
AUTHOR NAMES
  Bricker D.L.; Waltz T.A.; Telford R.J.; Beall A.C.
AUTHOR ADDRESSES
  (Bricker D.L.; Waltz T.A.; Telford R.J.; Beall A.C.) Div. Neurosurg., Cora 
Webb Mading Dept. Surg., Baylor Coll. Med., Houston, TX.
CORRESPONDENCE ADDRESS
  D.L. Bricker, Div. Neurosurg., Cora Webb Mading Dept. Surg., Baylor Coll. 
Med., Houston, TX.
FULL RECORD ENTRY DATE
  1971-12-01
SOURCE
  J.Trauma (1971) 11:1 (63-75). Date of Publication: 1971
VOLUME
  11
ISSUE
  1
FIRST PAGE
  63
LAST PAGE
  75
DATE OF PUBLICATION
  1971
ABSTRACT
  When injuries to the abdomen or thorax are associated with injuries to the 
spinal cord, the problems of management are greatly magnified. Eighteen 
patients with such injuries were seen during the past 3 years in Texas, and 
the problems and lessons learned during their management constituted the 
basis for this report. Preoperative, intraoperative, and postoperative 
problems were considered from the viewpoint of the general and thoracic 
surgeon, the neurosurgeon, and the anesthesiologist. The inadvisability of 
hasty laminectomy in these patients was stressed. The greatest challenge was 
found in the postoperative period, where respiratory insufficiency was the 
most prominent complication. Tracheostomy and assisted ventilation were 
frequently necessary, and the advent of the volume cycled respirator has 
proved a great advance. The effect of autonomie dysfunction on the 
cardiovascular, gastrointestinal, and genitourinary systems was evident in 
this group of patients, and some of the diagnostic and therapeutic pitfalls 
associated with such dysfunction were elucidated with select case 
presentations. The physiologic bases for the functional disturbances in 
these patients were discussed. Application of the principles outlined should 
minimize mortality and morbidity in this extraordinarily complex and 
challenging group of patients.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; thorax injury; 
EMTREE MEDICAL INDEX TERMS
  abdomen; abdominal injury; anesthesist; assisted ventilation; diagnosis; injury; laminectomy; morbidity; mortality; parkinsonism; patient; physiotherapy; postoperative period; respiratory failure; spinal cord; spinal cord lesion; thorax; thorax surgery; thorax wall; tracheostomy; United States; urogenital system; ventilator; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008469581
PUI
  L292060534
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Major+abdominal+and+thoracic+trauma+associated+with+spinal+cord+injury%3A+problems+in+management&stitle=J.Trauma&title=&volume=11&issue=1&spage=63&epage=75&aulast=Bricker&aufirst=D.L.&auinit=D.L.&aufull=Bricker+D.L.&coden=&isbn=&pages=63-75&date=1971&auinit1=D&auinitm=L
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1090
TITLE
  Penetrating wounds of the larynx and cervical trachea
AUTHOR NAMES
  Le May S.R.
AUTHOR ADDRESSES
  (Le May S.R.) Otolaryngol. Serv., Brocke Gen. Hosp., Fort Sam Houston, TX, 
United States.
CORRESPONDENCE ADDRESS
  S.R. Le May, Otolaryngol. Serv., Brocke Gen. Hosp., Fort Sam Houston, TX, 
United States.
FULL RECORD ENTRY DATE
  1971-12-01
SOURCE
  Archives of otolaryngology (1971) 94:6 (558-565). Date of Publication: 1971
VOLUME
  94
ISSUE
  6
FIRST PAGE
  558
LAST PAGE
  565
DATE OF PUBLICATION
  1971
ISSN
  0003-9977
ABSTRACT
  Twenty five cases of penetrating missile wounds involving the larynx and 
trachea are reported. Penetrating injuries of the anterior portion of the 
neck may have associated wounds of the larynx, pharynx, trachea, esophagus, 
major vessels, or spinal cord. Missiles crossing the midline of the neck are 
suspected of injuring the midline structures. Signs, symptoms, and 
diagnostic procedures are discussed. All neck wounds were debrided and 
explored to rule out deep structure injury. Surgical exploration of 
laryngotracheal injuries was directed toward open reduction and 
stabilization in position of function. The unfortunate complication of 
chronic stenosis of the larynx and trachea can be avoided in most 
penetrating missile wounds of the larynx and trachea.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  larynx; penetrating trauma; trachea; 
EMTREE MEDICAL INDEX TERMS
  diagnostic procedure; esophagus; injury; laryngoscopy; larynx injury; larynx stenosis; missile wound; neck; open reduction (procedure); pharynx; spinal cord; stenosis; trachea injury; trachea stenosis; tracheotomy; wound; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008893713
PUI
  L293151931
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00039977&id=doi:&atitle=Penetrating+wounds+of+the+larynx+and+cervical+trachea&stitle=Arch.+Otolaryng.&title=Archives+of+otolaryngology&volume=94&issue=6&spage=558&epage=565&aulast=Le+May&aufirst=S.R.&auinit=S.R.&aufull=Le+May+S.R.&coden=&isbn=&pages=558-565&date=1971&auinit1=S&auinitm=R
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1091
TITLE
  The cervical spine: Some clinical and practical considerations
AUTHOR NAMES
  England R.W.
AUTHOR ADDRESSES
  (England R.W.) Philadelphia Coll. Osteopathic Med., Philadelphia, PA 19131, 
United States.
CORRESPONDENCE ADDRESS
  R.W. England, Philadelphia Coll. Osteopathic Med., Philadelphia, PA 19131, 
United States.
FULL RECORD ENTRY DATE
  1971-12-01
SOURCE
  J. Amer. Osteopath. ass. (1971) 71:2 (129-146). Date of Publication: 1971
VOLUME
  71
ISSUE
  2
FIRST PAGE
  129
LAST PAGE
  146
DATE OF PUBLICATION
  1971
ABSTRACT
  Review of some of the basic techniques for treatment of problems of the 
cervical spine by the osteopathic family physician in his office, including 
a review of the anatomic and structural factors and the clinical approach. 
The method of taking the history, the physical examination, and the 
radiologic examination are outlined. The approach to be utilized in 
evaluation of somatic dysfunction of the cervical spine is detailed. The 
basic approaches to treatment and technique are presented.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; 
EMTREE MEDICAL INDEX TERMS
  assisted ventilation; endotracheal intubation; esophagus burn; general practitioner; medical decision making; physical examination; radiodiagnosis; tracheotomy; tube; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008894986
PUI
  L293153204
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=The+cervical+spine%3A+Some+clinical+and+practical+considerations&stitle=J.+Amer.+Osteopath.+ass.&title=&volume=71&issue=2&spage=129&epage=146&aulast=England&aufirst=R.W.&auinit=R.W.&aufull=England+R.W.&coden=&isbn=&pages=129-146&date=1971&auinit1=R&auinitm=W
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1092
TITLE
  Some problems of surgical tactics in complicated spinal fractures
ORIGINAL (NON-ENGLISH) TITLE
  Nekotorye voprosy khirurgicheskoi taktiki pri oslozhnennykh perelomakh 
pozvonochnika.
AUTHOR NAMES
  Lebedev V.V.; Isakov I.V.
AUTHOR ADDRESSES
  (Lebedev V.V.; Isakov I.V.)
CORRESPONDENCE ADDRESS
  V.V. Lebedev,
FULL RECORD ENTRY DATE
  1972-07-17
SOURCE
  Vestnik khirurgii imeni I. I. Grekova (1971) 107:12 (71-75). Date of 
Publication: Dec 1971
VOLUME
  107
ISSUE
  12
FIRST PAGE
  71
LAST PAGE
  75
DATE OF PUBLICATION
  Dec 1971
ISSN
  0042-4625
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fracture (surgery); spine injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  article; endotracheal intubation; human; osteosynthesis; procedures; tracheotomy; 
LANGUAGE OF ARTICLE
  Russian
MEDLINE PMID
  5148562 (http://www.ncbi.nlm.nih.gov/pubmed/5148562)
PUI
  L92460282
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00424625&id=doi:&atitle=Some+problems+of+surgical+tactics+in+complicated+spinal+fractures&stitle=Vestn.+Khir.+Im.+I.+I.+Grek.&title=Vestnik+khirurgii+imeni+I.+I.+Grekova&volume=107&issue=12&spage=71&epage=75&aulast=Lebedev&aufirst=V.V.&auinit=V.V.&aufull=Lebedev+V.V.&coden=&isbn=&pages=71-75&date=1971&auinit1=V&auinitm=V
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1093
TITLE
  The ability of man to detect added resistive loads to breathing.
AUTHOR NAMES
  Noble M.I.; Frankel H.L.; Else W.; Guz A.
AUTHOR ADDRESSES
  (Noble M.I.; Frankel H.L.; Else W.; Guz A.)
CORRESPONDENCE ADDRESS
  M.I. Noble,
FULL RECORD ENTRY DATE
  1971-11-16
SOURCE
  Clinical science (1971) 41:3 (285-287). Date of Publication: Sep 1971
VOLUME
  41
ISSUE
  3
FIRST PAGE
  285
LAST PAGE
  287
DATE OF PUBLICATION
  Sep 1971
ISSN
  0009-9287
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway resistance; sensation; 
EMTREE MEDICAL INDEX TERMS
  adult; article; human; male; mechanical stress; pathophysiology; sensory receptor; spinal cord injury; tracheotomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  5571506 (http://www.ncbi.nlm.nih.gov/pubmed/5571506)
PUI
  L91459392
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00099287&id=doi:&atitle=The+ability+of+man+to+detect+added+resistive+loads+to+breathing.&stitle=Clin+Sci&title=Clinical+science&volume=41&issue=3&spage=285&epage=287&aulast=Noble&aufirst=M.I.&auinit=M.I.&aufull=Noble+M.I.&coden=&isbn=&pages=285-287&date=1971&auinit1=M&auinitm=I
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1094
TITLE
  Spinal cord injuries. an analysis of 300 new lesions
AUTHOR NAMES
  Key A.G.; Relief P.J.M.
AUTHOR ADDRESSES
  (Key A.G.; Relief P.J.M.) Spin. Cord Injury Cent, Conradie Hosp., Cape Town, 
South Africa.
CORRESPONDENCE ADDRESS
  A.G. Key, Spin. Cord Injury Cent, Conradie Hosp., Cape Town, South Africa.
FULL RECORD ENTRY DATE
  1970-12-01
SOURCE
  Paraplegia (1970) 7:4 (243-249). Date of Publication: 1970
VOLUME
  7
ISSUE
  4
FIRST PAGE
  243
LAST PAGE
  249
DATE OF PUBLICATION
  1970
ISSN
  0031-1758
ABSTRACT
  An analysis of 300 new lesions admitted to u spinal injuries centre. 
Statistics given relate to the following: (1) mode of transport to the 
centre; (2) age and sex distributiv;., (3) cause and frequency of spinal 
cord lesions; (4) neurological classification - incidence and extent; (5) 
general nursing care; (6) plastic repair of sores; (7) incidence of 
automatic and autonomous bladders and treatment; (8) orthopaedic procedures; 
(9) tracheostomy; (10) death rate; (11) discharges, and (12) out patient 
attendance.
EMTREE DRUG INDEX TERMS
  plastic; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spinal cord injury; 
EMTREE MEDICAL INDEX TERMS
  bladder; classification; mortality; nursing care; outpatient; spinal cord lesion; spine injury; statistics; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008569004
PUI
  L290071171
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Spinal+cord+injuries.+an+analysis+of+300+new+lesions&stitle=Paraplegia&title=Paraplegia&volume=7&issue=4&spage=243&epage=249&aulast=Key&aufirst=A.G.&auinit=A.G.&aufull=Key+A.G.&coden=&isbn=&pages=243-249&date=1970&auinit1=A&auinitm=G
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1095
TITLE
  Tracheal stenosis following tracheostomy.
AUTHOR NAMES
  Frankel H.L.
AUTHOR ADDRESSES
  (Frankel H.L.)
CORRESPONDENCE ADDRESS
  H.L. Frankel,
FULL RECORD ENTRY DATE
  1971-04-24
SOURCE
  Paraplegia (1970) 8:3 (172-176). Date of Publication: Nov 1970
VOLUME
  8
ISSUE
  3
FIRST PAGE
  172
LAST PAGE
  176
DATE OF PUBLICATION
  Nov 1970
ISSN
  0031-1758
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  trachea stenosis (etiology); tracheotomy (adverse drug reaction); 
EMTREE MEDICAL INDEX TERMS
  adolescent; adult; article; cauda equina; female; human; injury; male; paraplegia; positive end expiratory pressure (adverse drug reaction); spinal cord injury; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  4926412 (http://www.ncbi.nlm.nih.gov/pubmed/4926412)
PUI
  L91373424
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Tracheal+stenosis+following+tracheostomy.&stitle=Paraplegia&title=Paraplegia&volume=8&issue=3&spage=172&epage=176&aulast=Frankel&aufirst=H.L.&auinit=H.L.&aufull=Frankel+H.L.&coden=&isbn=&pages=172-176&date=1970&auinit1=H&auinitm=L
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1096
TITLE
  The problems presented in a reanimation service by fractures of the cervical 
spine during the first few months
ORIGINAL (NON-ENGLISH) TITLE
  Les problemes poses dans un service de reanimation par les fractures du 
hachis cervical pendant les premiers mois
AUTHOR NAMES
  Goulon M.; Bigot B.
AUTHOR ADDRESSES
  (Goulon M.; Bigot B.) Serv. Reanim. Reeduc. Motrice, .
CORRESPONDENCE ADDRESS
  M. Goulon, Serv. Reanim. Reeduc. Motrice, .
FULL RECORD ENTRY DATE
  1969-12-01
SOURCE
  Ann.Med.Phys. (1969) 12:3 (166-167). Date of Publication: 1969
VOLUME
  12
ISSUE
  3
FIRST PAGE
  166
LAST PAGE
  167
DATE OF PUBLICATION
  1969
ABSTRACT
  The authors discuss 8 cases of fractures of the cervical spine with 
quadriplegia, admitted for problems connected with resuscitation. Among the 
most important complications were: Polyuria up to 5 liters per day, with 
polydipsia, in the early weeks after injury; psychological disorders in 2 
patients; temperature disturbances (hypo- or hyperthermia), though whether 
the basis on those was central or infective was not established; respiratory 
difficulties, which were among the most important. In this series 7 patients 
were tracheotomised, 5 in the first 48 hr, and 5 were on artificial 
respiration. In the authors' view, tracheotomy is preferable to intubation 
in these cases, and it is better to perform tracheotomy too often than to 
submit the patient to risk by omitting this precaution. In the discussion, 
Professor Gabibert was surprised at the low incidence of hypothermie 
complications. Professor Grossiord emphasized the problems involved in the 
indications for tracheotomy, and Dr. Dollfus stressed the risk of cardiac 
arrest during tracheotomy. (Paradystal - Lidkoping).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; fracture; resuscitation; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; breathing; cardiovascular system; cervical spine fracture; digestion; heart arrest; hyperthermia; injury; intubation; mental disease; patient; polydipsia; polyuria; psychology; quadriplegia; risk; spinal cord lesion; temperature; tracheotomy; urology; 
LANGUAGE OF ARTICLE
  Danish
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008959469
PUI
  L291119003
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=The+problems+presented+in+a+reanimation+service+by+fractures+of+the+cervical+spine+during+the+first+few+months&stitle=Ann.Med.Phys.&title=&volume=12&issue=3&spage=166&epage=167&aulast=Goulon&aufirst=M.&auinit=M.&aufull=Goulon+M.&coden=&isbn=&pages=166-167&date=1969&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1097
TITLE
  Radical treatment of cervicodorsal spinal tuberculosis
AUTHOR NAMES
  Fang H.S.Y.; Ong G.B.
AUTHOR ADDRESSES
  (Fang H.S.Y.; Ong G.B.) Dept. of Surg., Univ. of Hong Kong, .
CORRESPONDENCE ADDRESS
  H.S.Y. Fang, Dept. of Surg., Univ. of Hong Kong, .
FULL RECORD ENTRY DATE
  1969-12-01
SOURCE
  Journal of the Royal College of Surgeons of Edinburgh (1969) 14:1 (20-30). 
Date of Publication: 1969
VOLUME
  14
ISSUE
  1
FIRST PAGE
  20
LAST PAGE
  30
DATE OF PUBLICATION
  1969
ISSN
  0035-8835
ABSTRACT
  28 patients with cervico dorsal spinal tuberculosis have been treated by 
means of radical surgery during the last 10 years. The approach adopted was 
one first described by Cauchoix and Binet (1956). There were 2 postoperative 
deaths from aspiration of blood into the lungs through a tracheostomy tube. 
In fact, tracheostomy is not necessary. After debridement of the diseased 
vertebrae, anterior spinal fusion was carried out in each instance. As many 
as 6 vertebrae had been fused successfully.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tuberculous spondylitis; 
EMTREE MEDICAL INDEX TERMS
  anterior spine fusion; aspiration; blood; death; debridement; lung; patient; spine surgery; surgery; tracheostomy; tube; vertebra; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008438345
PUI
  L289090805
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00358835&id=doi:&atitle=Radical+treatment+of+cervicodorsal+spinal+tuberculosis&stitle=J.+Roy.+Coll.+Surg.+Edinb.&title=Journal+of+the+Royal+College+of+Surgeons+of+Edinburgh&volume=14&issue=1&spage=20&epage=30&aulast=Fang&aufirst=H.S.Y.&auinit=H.S.Y.&aufull=Fang+H.S.Y.&coden=&isbn=&pages=20-30&date=1969&auinit1=H&auinitm=S.Y.
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1098
TITLE
  The problems presented in a reanimation service by fractures of the cervical 
spine during the first few months
ORIGINAL (NON-ENGLISH) TITLE
  Les problemes poses dans un service de reanimation par les fractures du 
rachis cervical pendant les premiers mois
AUTHOR NAMES
  Goulon M.; Bigot B.; Lougovoy Vistonti J.
AUTHOR ADDRESSES
  (Goulon M.; Bigot B.; Lougovoy Vistonti J.) Serv. Reanim. Reeduc. Motrice, 
Hop. Raymond Poincare, Garches, France.
()
CORRESPONDENCE ADDRESS
  M. Goulon, Serv. Reanim. Reeduc. Motrice, Hop. Raymond Poincare, Garches, 
France.
FULL RECORD ENTRY DATE
  1969-12-01
SOURCE
  Annales de Medecine Physique (1969) 12:3 (223-232). Date of Publication: 
1969
VOLUME
  12
ISSUE
  3
FIRST PAGE
  223
LAST PAGE
  232
DATE OF PUBLICATION
  1969
ABSTRACT
  The authors discuss 8 cases of fractures of the cervical spine with 
quadriplegia, admitted for problems connected with resuscitation. Among the 
most important complications were: Polyuria up to 5 liters per day, with 
polydipsia, in the early weeks after injury; psychological disorders in 2 
patients; temperature disturbances (hypo- or hypertheimia), though whether 
the basis on those was central or infective was not established; respiratory 
difficulties, which were among the most important. In this series 7 patients 
were tracheotomised, 5 in the first 48 hr, and 5 were on artificial 
respiration. In the authors' view, tracheotomy is preferable to intubation 
in these cases, and it is better to perform tracheotomy too often than to 
submit the patient to risk by omitting this precaution. In the discussion. 
Professor Gabibert was surprised at the low incidence of hypothermic 
complications. Professor Grossiord emphasized the problems involved in the 
indications for tracheotomy, and Dr. Dollfus stressed the risk of cardiac 
arrest during tracheotomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; fracture; resuscitation; 
EMTREE MEDICAL INDEX TERMS
  artificial ventilation; bradycardia; cervical spine fracture; heart arrest; hypotension; injury; intubation; mental disease; paralysis; patient; polydipsia; polyuria; quadriplegia; respiratory failure; risk; temperature; tracheotomy; 
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008936291
PUI
  L291115574
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=The+problems+presented+in+a+reanimation+service+by+fractures+of+the+cervical+spine+during+the+first+few+months&stitle=Ann.+Med.+Phys.&title=Annales+de+Medecine+Physique&volume=12&issue=3&spage=223&epage=232&aulast=Goulon&aufirst=M.&auinit=M.&aufull=Goulon+M.&coden=&isbn=&pages=223-232&date=1969&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1099
TITLE
  Radical treatment of cervico-dorsal spinal tuberculosis.
AUTHOR NAMES
  Fang H.S.; Ong G.B.
AUTHOR ADDRESSES
  (Fang H.S.; Ong G.B.)
CORRESPONDENCE ADDRESS
  H.S. Fang,
FULL RECORD ENTRY DATE
  1969-08-19
SOURCE
  Journal of the Royal College of Surgeons of Edinburgh (1969) 14:1 (20-30). 
Date of Publication: Jan 1969
VOLUME
  14
ISSUE
  1
FIRST PAGE
  20
LAST PAGE
  30
DATE OF PUBLICATION
  Jan 1969
ISSN
  0035-8835
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  tuberculous spondylitis (surgery); 
EMTREE MEDICAL INDEX TERMS
  adolescent; article; child; female; human; male; postoperative care; preschool child; spine fusion; tracheotomy (adverse drug reaction); 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  5791259 (http://www.ncbi.nlm.nih.gov/pubmed/5791259)
PUI
  L89145130
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00358835&id=doi:&atitle=Radical+treatment+of+cervico-dorsal+spinal+tuberculosis.&stitle=J+R+Coll+Surg+Edinb&title=Journal+of+the+Royal+College+of+Surgeons+of+Edinburgh&volume=14&issue=1&spage=20&epage=30&aulast=Fang&aufirst=H.S.&auinit=H.S.&aufull=Fang+H.S.&coden=&isbn=&pages=20-30&date=1969&auinit1=H&auinitm=S
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1100
TITLE
  The early management of associated injuries in the presence of coincident 
damage to the spinal cord
AUTHOR NAMES
  McSweeney T.
AUTHOR ADDRESSES
  (McSweeney T.) Robert Jones and Agnes Hunt Orthop. Hosp., Oswestry.
CORRESPONDENCE ADDRESS
  T. McSweeney, Robert Jones and Agnes Hunt Orthop. Hosp., Oswestry.
FULL RECORD ENTRY DATE
  1968-12-01
SOURCE
  Paraplegia (1968) 5:4 (189-196). Date of Publication: 1968
VOLUME
  5
ISSUE
  4
FIRST PAGE
  189
LAST PAGE
  196
DATE OF PUBLICATION
  1968
ISSN
  0031-1758
ABSTRACT
  Tracneostomy is seldom necessary in dorsal or lumbar paraplegia, except in 
the presence of a severe chest injury. In cervical cord injury there is the 
risk of over-transfusion. In dorsal and lumbar paraplegia the risk of 
over-transfusion is not so great. Soft tissue wounds and compound fractures 
of limbs are thoroughly cleaned, devitalised tissue excised and simple 
closure undertaken as soon as the patient's general condition will permit. 
For single bone injuries, it may be possible to dispense with splints and 
make use of a pillow and crepe bandage to support the limb. Uncomplicated 
dislocations are promptly and gently reduced. Absolute indications for 
surgery are fractures accompanied by gross pressure on vessels or nerves, or 
where an attempt at closed reduction may increase the neurovascular hazard; 
such cases require exploration and reduction. It is not advisable to accept 
gross angular deformity in an anaesthetic limb because of the difficulty of 
fitting appliances at a later stage. Open reduction of fractures should be 
considered when these are irreducible, unstable or where the fragment is so 
small that it cannot be manipulated. Operation is required only in a 
minority of head injuries. The author recognises three indications for 
urgent cranial surgery:(1) Compound fracture of the skull. (2) Expanding 
lesions within the skull. (3) Certain fractures involving the sinuses. The 
need for exploration is obvious by open wounds of the abdomen associated 
with spinal injuries. Inspection, percussion, palpation and auscultation may 
throw little light on the problem of injuries of abdomen when the spinal 
cord is damaged. An accurate history, careful clinical investigation 
frequently repeated and X- ray studies including the use of contrast media 
will help in deciding about laparotomy. In tétraplé gie patients with severe 
associated chest injuries, tracheostomy is vital. By chest injuries five 
basic principles must be remembered: (1) The relief of tension pneumothorax 
by a lollow needle. (2) Immediate closure of a sucking meumcthorax. (3) 
Correction of paradoxical respiration due to flail chest. (4) Frequent 
onchoscopic toilet. (5) Aspiration of the pleural cavity is often advisable 
and when intercostal lrainage is necessary, it should be carried out hrough 
a wide-bore tube with an under-water seal. Mastny - Brno (19, 8A, 9B*).
EMTREE DRUG INDEX TERMS
  anesthetic agent; contrast medium; water; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; spinal cord; 
EMTREE MEDICAL INDEX TERMS
  abdomen; aspiration; auscultation; bandage; bone injury; cervical spinal cord injury; deformity; flail chest; fracture; fracture reduction; general condition; hazard; head injury; laparotomy; limb; needle; nerve; open fracture; open reduction (procedure); palpation; paraplegia; patient; percussion; pleura cavity; pneumothorax; risk; skull; skull surgery; soft tissue injury; spine injury; splint; sucking; surgery; thorax injury; tissues; tracheostomy; transfusion; tube; wound; X ray; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007815364
PUI
  L288042759
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=The+early+management+of+associated+injuries+in+the+presence+of+coincident+damage+to+the+spinal+cord&stitle=Paraplegia&title=Paraplegia&volume=5&issue=4&spage=189&epage=196&aulast=McSweeney&aufirst=T.&auinit=T.&aufull=McSweeney+T.&coden=&isbn=&pages=189-196&date=1968&auinit1=T&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1101
TITLE
  Fatal road accidents. Injuries, complications, and causes of death in 250 
subjects
AUTHOR NAMES
  Sevitt S.
AUTHOR ADDRESSES
  (Sevitt S.) Pathol. Dept., Birmingham Accident Hosp., Birmingham.
CORRESPONDENCE ADDRESS
  S. Sevitt, Pathol. Dept., Birmingham Accident Hosp., Birmingham.
FULL RECORD ENTRY DATE
  1968-12-01
SOURCE
  British Journal of Surgery (1968) 55:7 (481-505). Date of Publication: 1968
VOLUME
  55
ISSUE
  7
FIRST PAGE
  481
LAST PAGE
  505
DATE OF PUBLICATION
  1968
ISSN
  0007-1323
ABSTRACT
  An analysis has been made of the injuries, complications, and causes of 
death of 250 road-accident victims comprising 125 pedestrians (507.)i 41 
motor-cyclists, 18 pedal cyclists, 30 vehicle drivers, 26 vehicle 
passengers, 6 bus passengers, and 4 other subjects. Pre-existing disease was 
responsible for the accident in 4 car drivers and caused the death of 2 of 
them. Head and chest injuries predominated, affecting 70 and 45% 
respectively, of all subjects, followed by lower-limb fractures (34%)l 
fractures of the pelvis (237.). abdominal injuries (19*4 fractures and 
dislocations of the spine (14%) and upper limb (14%). Multiple injuries were 
the rule and two or more body regions were involved in two-thirds of the 
cases, the head and chest together in 28%. The main difference between the 
different road users was a high frequency of pelvic and lower-limb fractures 
in pedestrians (36% and 48%, respectively); a very high rate of head 
injuries in motor-cyclists and vehicle passengers (80%); and in vehicle 
drivers a high and equal frequency of head injuries (63%) and chest injury 
(67%} commonly with abdominal trauma (37%) and spinal injuries confined to 
the neck. Sixteen per cent of the subjects died soon after the accident and 
44% of those reaching hospital alive died within 24 hours of injury (28% 
within 6 hours). At this time the main causes of death were cerebral injury 
and severe hemorrhage - generally hopeless cases. Head, chest and abdominal 
trauma were divided into major and minor types. Early death after head 
injury was usually due to a direct contusion of the brain-stem or third 
ventricular region, but many deaths during the first hours and subsequent 
days were from the complication of tentorial herniation ol the midbrain. 
following subdural hemorrhage and the associated frontal or temporal coup or 
contrecoup lesions. Theoretically this is preventable and requires fuller 
study. Many deaths were attributable to chest injuries but few to abdominal 
trauma. Fourteen patients had a ruptured aorta, most of them just beyond the 
arch. Some burst hours or days after injury and might have been amenable to 
surgery. The mechanism of most' aortic ruptures seems to be aortic 
elongation, following deceleration from a cephalically directed body 
movement. Most chest injuries had multiple unilateral or bilateral rib 
fractures and were due to compression, but some resulted from hyperflexion 
of the upper on the lower chest or vice versa and then the dorsal spine was 
also fractured Sternal fractures or subluxation were either inwardly 
directed injuries from compression or outward bucklings from forced chest 
hyperflexion. Lung lacerations were either peripheral tears from penetrating 
ribs or central disruptions, probably a burst type of injury. Injuries to 
the cervical spine (20 patients) were mainly hyperextension subluxations of 
hyperflexion fracture-dislocations, but a few patients had axis or odontoid 
fractures. A dislocated cervical spine was found in 7% of those major head 
injuries. Complications were either specific to trauma or were of àmore 
general nature,- they were frequent and numerous, and not infrequently two 
or even three occurred in the one subject. Numerically the most important 
were tentorial herniation, severe hemorrhage, and respiratory infection 
which form the lethal triad after injury, each contributing to or causing 
between 2OX and 25*4 of the deaths; then came pulmonary embolism, pulmonary 
edema, pneumothorax, cerebral fat embolism, and inhalation of vomit, 
followed by septicémie, acute renal failure, pneumococcal meningitis, air 
embolism, and a variety of other general and local complications. No 
evidence of so-called irreversible shock after adequate transfusion was 
found. The relatively low frequency of acute renal failure is attributable 
to a clinical policy of early and adequate blood transfusion,- and the rate 
of pulmonary embolism might have been higher were it not for a hospital 
policy of anticoagulant prophylaxis with oral drugs. A few patients might 
have been saved from death from hemorrhage and others from death from 
embolism. The problem of bronchopneumonia and its relationship to 
tracheostomy and cross-infection in hospital needs solution.
EMTREE DRUG INDEX TERMS
  anticoagulant agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  death; injury; traffic accident; 
EMTREE MEDICAL INDEX TERMS
  abdominal injury; accident; acute kidney failure; air embolism; aorta; aortic rupture; arm; bacterial meningitis; bleeding; blood transfusion; body movement; body regions; brain injury; brain stem; bronchopneumonia; car driver; cervical spine; compression; contusion; cross infection; cycling; deceleration; embolism; fat embolism; fatality; fracture; fracture dislocation; head injury; hernia; hospital; hospital policy; inhalation; laceration; lacrimal fluid; leg; limb fracture; lung; lung edema; lung embolism; mesencephalon; multiple trauma; neck; odontoid process fracture; patient; pedestrian; pelvis; pneumothorax; policy; prophylaxis; respiratory tract infection; rib; rib fracture; spine; spine injury; subdural hematoma; subluxation; surgery; thorax; thorax injury; tracheostomy; transfusion; victim; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007550303
PUI
  L289028344
DOI
  10.1002/bjs.1800550702
FULL TEXT LINK
  http://dx.doi.org/10.1002/bjs.1800550702
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00071323&id=doi:10.1002%2Fbjs.1800550702&atitle=Fatal+road+accidents.+Injuries%2C+complications%2C+and+causes+of+death+in+250+subjects&stitle=Brit.+J.+Surg.&title=British+Journal+of+Surgery&volume=55&issue=7&spage=481&epage=505&aulast=Sevitt&aufirst=S.&auinit=S.&aufull=Sevitt+S.&coden=&isbn=&pages=481-505&date=1968&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1102
TITLE
  Associated chest injuries
AUTHOR NAMES
  Frankel H.L.
AUTHOR ADDRESSES
  (Frankel H.L.) Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., Aylesbury, 
United Kingdom.
CORRESPONDENCE ADDRESS
  H.L. Frankel, Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., Aylesbury, 
United Kingdom.
FULL RECORD ENTRY DATE
  1968-12-01
SOURCE
  Paraplegia (1968) 5:4 (221-225). Date of Publication: 1968
VOLUME
  5
ISSUE
  4
FIRST PAGE
  221
LAST PAGE
  225
DATE OF PUBLICATION
  1968
ISSN
  0031-1758
ABSTRACT
  Thoracic lesions, often seen in transverse lesions at the thoracic and 
thoracolumbar level, and rarely in cervical lesions, should be diagnosed and 
treated as soon as possible. The following are discussed: costal fractures, 
hemothorax, pneumothorax, lesions to the diaphragm or phrenic nerve, lesions 
to the lung tissues, pulmonary vessels and mediastinum including the heart, 
tracheotomy and the unavoidable frequent complications thereof.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  thorax injury; 
EMTREE MEDICAL INDEX TERMS
  diaphragm; heart; hematothorax; injury; lung blood vessel; lung parenchyma; mediastinum; phrenic nerve; pneumothorax; rib fracture; spinal cord lesion; spinal cord transverse lesion; thorax wall; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008013659
PUI
  L289039934
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Associated+chest+injuries&stitle=Paraplegia&title=Paraplegia&volume=5&issue=4&spage=221&epage=225&aulast=Frankel&aufirst=H.L.&auinit=H.L.&aufull=Frankel+H.L.&coden=&isbn=&pages=221-225&date=1968&auinit1=H&auinitm=L
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1103
TITLE
  Emergency measures in the treatment of patients with cervical 
vertebro-medullary injuries
ORIGINAL (NON-ENGLISH) TITLE
  Misure d'emergenza nel trattamento del traumatizzato vertebro-midollare 
cervicale.
AUTHOR NAMES
  Merli G.A.; Gritti G.; Manani G.; Manzin E.
AUTHOR ADDRESSES
  (Merli G.A.; Gritti G.; Manani G.; Manzin E.)
CORRESPONDENCE ADDRESS
  G.A. Merli,
FULL RECORD ENTRY DATE
  1970-11-08
SOURCE
  Acta anaesthesiologica (1968) 19 (Suppl 9:240+). Date of Publication: 1968
VOLUME
  19
DATE OF PUBLICATION
  1968
ISSN
  0001-5156
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; quadriplegia (therapy); spinal cord injury (therapy); spine injury (complication, therapy); 
EMTREE MEDICAL INDEX TERMS
  adult; article; artificial ventilation; bladder disease (etiology); decubitus (therapy); dislocation; enteropathy (etiology); female; first aid; fracture; fracture fixation; human; male; middle aged; respiratory tract disease (etiology); tracheotomy; traction therapy; 
LANGUAGE OF ARTICLE
  Italian
MEDLINE PMID
  5757615 (http://www.ncbi.nlm.nih.gov/pubmed/5757615)
PUI
  L90464043
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00015156&id=doi:&atitle=Emergency+measures+in+the+treatment+of+patients+with+cervical+vertebro-medullary+injuries&stitle=Acta+Anaesthesiol&title=Acta+anaesthesiologica&volume=19&issue=&spage=&epage=&aulast=Merli&aufirst=G.A.&auinit=G.A.&aufull=Merli+G.A.&coden=&isbn=&pages=-&date=1968&auinit1=G&auinitm=A
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1104
TITLE
  Tracheostomy in acute injury and acute vascular pathology of the central 
nervous system
ORIGINAL (NON-ENGLISH) TITLE
  Trakheostomiia pri ostroi travme i ostroi sosudistoi patologii tsentral'noi 
nervnoi sistemy.
AUTHOR NAMES
  Panchulidze I.A.
AUTHOR ADDRESSES
  (Panchulidze I.A.)
CORRESPONDENCE ADDRESS
  I.A. Panchulidze,
FULL RECORD ENTRY DATE
  1970-09-29
SOURCE
  Khirurgiia (1968) 44:6 (126-131). Date of Publication: Jun 1968
VOLUME
  44
ISSUE
  6
FIRST PAGE
  126
LAST PAGE
  131
DATE OF PUBLICATION
  Jun 1968
ISSN
  0023-1207
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury (complication); cerebrovascular disease (complication); paralysis (etiology, therapy); respiratory failure (etiology, therapy); spinal cord injury (complication); tracheotomy; 
EMTREE MEDICAL INDEX TERMS
  article; artificial ventilation; human; wound drainage; 
LANGUAGE OF ARTICLE
  Russian
MEDLINE PMID
  5746448 (http://www.ncbi.nlm.nih.gov/pubmed/5746448)
PUI
  L90435575
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00231207&id=doi:&atitle=Tracheostomy+in+acute+injury+and+acute+vascular+pathology+of+the+central+nervous+system&stitle=Khirurgiia+%28Mosk%29&title=Khirurgiia&volume=44&issue=6&spage=126&epage=131&aulast=Panchulidze&aufirst=I.A.&auinit=I.A.&aufull=Panchulidze+I.A.&coden=&isbn=&pages=126-131&date=1968&auinit1=I&auinitm=A
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1105
TITLE
  Thoracic trauma and associated injuries -
ORIGINAL (NON-ENGLISH) TITLE
  Traumatisme s thoraciquee et traumatismes associés
AUTHOR NAMES
  Proye C.
AUTHOR ADDRESSES
  (Proye C.)
FULL RECORD ENTRY DATE
  1967-12-01
SOURCE
  Lille chirurgical (1967) 22:1 (58-64). Date of Publication: 1967
VOLUME
  22
ISSUE
  1
FIRST PAGE
  58
LAST PAGE
  64
DATE OF PUBLICATION
  1967
ISSN
  0024-3493
ABSTRACT
  Thoracic injury is often associated with severe trauma to other organs, e. 
g. in 121 out of the presented 313 cases. Common mistakes made in handling 
such injuries are: to attribute the respiratory symptoms to the associated 
cranial or facial injuries; to attribute the shock to a moderate hemothorax; 
to regard cases of thoracic injury as 'untouchable' and omit a lifesaving 
laparotomy. or fraction fixation; to carry out a laparotomy for spasm which 
is due merely to rib injury. To avoid such errors a thorough examination is 
necessary i. e. a systematic clinical examination; X-ray examination should 
include the skull, spine, chest and pelvis; no lesion should be ignored, but 
the thoracic lesion is the most urgent; no general anesthetic should be 
given until respiration has been controlled by tracheostomy. pleural 
drainage and rib fixation. Faciomaxillary injuries only occurred in 8 cases 
and jaw fractures in 134 during 15 yr. Their treatment may be delayed for 6 
hr up to 3 days, but not for a week without danger. Intracranial injuries 
occurred in 126 out of 730 cases. In Uusee lhe cerebral edema, anoxia and 
electrolytic balance are upset by the associated thoracic injury, which may 
induce pulmonary edema and CheyneStokes respiration. The assessment of the 
relative importance of these features may be difficult. Respiratory control 
must be attained before any move to a brain-surgery unit. The only urgent 
cerebral emergency is extra-dural hemorrhage. Cervical spinal injuries also 
require early operation in the prone position.
EMTREE DRUG INDEX TERMS
  anesthetic agent; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  injury; thorax injury; 
EMTREE MEDICAL INDEX TERMS
  anoxia; bleeding; body position; brain edema; brain surgery; cervical spine injury; clinical examination; electrolyte balance; emergency; error; examination; face injury; hematothorax; jaw fracture; laparotomy; lung edema; muscle spasm; pelvis; radiodiagnosis; respiration control; rib; skull; spine; thorax; tracheostomy; 
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007984826
PUI
  L287069656
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00243493&id=doi:&atitle=Thoracic+trauma+and+associated+injuries+-&stitle=Lille+Chir.&title=Lille+chirurgical&volume=22&issue=1&spage=58&epage=64&aulast=Proye&aufirst=C.&auinit=C.&aufull=Proye+C.&coden=&isbn=&pages=58-64&date=1967&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1106
TITLE
  Recent developments in the treatment of tetraplegics
AUTHOR NAMES
  Walsh J.J.
AUTHOR ADDRESSES
  (Walsh J.J.) Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., Aylesbury, 
United Kingdom.
CORRESPONDENCE ADDRESS
  J.J. Walsh, Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., Aylesbury, 
United Kingdom.
FULL RECORD ENTRY DATE
  1966-12-01
SOURCE
  Physiotherapy (1966) 52:11 (396-399). Date of Publication: 1966
VOLUME
  52
ISSUE
  11
FIRST PAGE
  396
LAST PAGE
  399
DATE OF PUBLICATION
  1966
ISSN
  0031-9406
ABSTRACT
  The increasing number of tetraplegic patients admitted to spinal injuries 
centers throughout the world demand the need for a very high standard of 
physiotherapy. This paper deals in some detail with the problem of 
prophylactic and curative physiotherapy for chest complications in 
tetraplegics, and also discusses the indications for tracheostomy and its 
management. The place of electrotherapy in tetraplegia is discussed. 
Reference is made to some of the recent advances in designing special 
apparatus including powered chairs, selector mechanisms and the Egerton 
Stoke Mandeville bed.
EMTREE MEDICAL INDEX TERMS
  electrotherapy; patient; physiotherapy; quadriplegia; spine injury; thorax; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007912987
PUI
  L287053652
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00319406&id=doi:&atitle=Recent+developments+in+the+treatment+of+tetraplegics&stitle=Physiotherapy&title=Physiotherapy&volume=52&issue=11&spage=396&epage=399&aulast=Walsh&aufirst=J.J.&auinit=J.J.&aufull=Walsh+J.J.&coden=&isbn=&pages=396-399&date=1966&auinit1=J&auinitm=J
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1107
TITLE
  Infectious mononucleosis: neurologic and eeg findings
AUTHOR NAMES
  Schnell R.G.; Dyck P.J.; Bowle E.J.W.; Klass D.W.; Taswell H.F.
AUTHOR ADDRESSES
  (Schnell R.G.; Dyck P.J.; Bowle E.J.W.; Klass D.W.; Taswell H.F.) Dept. of 
Neurol., Mayo Grad. Sch. of Med., Univ. of Minnesota, Rochester, MN, United 
States.
CORRESPONDENCE ADDRESS
  R.G. Schnell, Dept. of Neurol., Mayo Grad. Sch. of Med., Univ. of Minnesota, 
Rochester, MN, United States.
FULL RECORD ENTRY DATE
  1966-12-01
SOURCE
  Medicine (1966) 45:1 (51-63). Date of Publication: 1966
VOLUME
  45
ISSUE
  1
FIRST PAGE
  51
LAST PAGE
  63
DATE OF PUBLICATION
  1966
ISSN
  1357-3039
ABSTRACT
  From 1950 through 1963, a diagnosis of infectious mononucleosis was made in 
I, 285 cases. Of 44 patients, 12 met the authors' criteria for the diagnosis 
of infectious mononucleosis and had nervous-system involvement secondary to 
the mononucleosis. These patients, 11 male and 1 female, ranged in age from 
13 to 27 years. Eight of the 12 had acute meningoencephalomyelitis of short 
duration. This was characterized by headache, fever, stiff neck, delirium, 
and confusion. Additional manifestations, in some cases included combative 
and irrational behavior, seizures, papilledema, and signs of cerebellar 
dysfunction. The electroencephalograms of 7 cases were abnormal. The changes 
were predominantly diffuoe and of uillu degree but occasionally wer? ,evere 
and localized. Of the remaining patients, one had predominantly spinal 
cord'involvement, two had polyradiculopathy, and one had mononeuritis. The 
findings indicate that when the nervous system is affected by infectious 
mononucleosis, the neurologic symptoms and signs may predominate and obscure 
the usual presenting symptoms. Such cases may present as an acute psychosis 
or a convulsive disorder, as men ingoen cephalitis, as myelitis, or as 
peripheral neuropathy or mononeuropathy. A striking feature of these cases 
was the good prognosis and lack of neurologic residua even when marked 
neurologic abnormalities had been present during the acute phase of the 
illness. Tracheostomy and mechanical respiration were important in the 
treatment of those patients who had respiratory failure due to brain-stem or 
peripheralnerve involvement. Steroids, used in two of the cases, may have 
been helpful in the treatment of these severely ill patients. Although 
patients with neurologic involvement from infectious mononucleosis can be 
critically ill, in the authors' opinion, the improved methods of symptomatic 
treatment have favorably altered the previously grave prognosis,.
EMTREE DRUG INDEX TERMS
  steroid; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  mononucleosis; 
EMTREE MEDICAL INDEX TERMS
  acute psychosis; artificial ventilation; brain stem; convulsion; critically ill patient; delirium; diagnosis; electroencephalogram; female; fever; general aspects of disease; headache; infectious hepatitis; male; mononeuropathy; mononucleosis; myelitis; neck; nervous system; neurologic disease; palliative therapy; papilledema; patient; peripheral neuropathy; prognosis; radiculopathy; respiratory failure; seizure; spinal cord; tracheostomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008035312
PUI
  L287081352
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=13573039&id=doi:&atitle=Infectious+mononucleosis%3A+neurologic+and+eeg+findings&stitle=Medicine&title=Medicine&volume=45&issue=1&spage=51&epage=63&aulast=Schnell&aufirst=R.G.&auinit=R.G.&aufull=Schnell+R.G.&coden=&isbn=&pages=51-63&date=1966&auinit1=R&auinitm=G
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1108
TITLE
  Clinico-pathological study of devic's optic neuromyelitis with artificially 
prolonged course. terminal septic encephalitis
ORIGINAL (NON-ENGLISH) TITLE
  Etude anatomo-clinique d'une neuromyélite optique de Dévie, d'évolution 
artificiellement prolongée. Encéphalite septique terminale
AUTHOR NAMES
  Tommasi M.; Lecuire J.; Masquin A.; Buffat J.J.
AUTHOR ADDRESSES
  (Tommasi M.; Lecuire J.; Masquin A.; Buffat J.J.)
CORRESPONDENCE ADDRESS
  M. Tommasi, Lyon.
FULL RECORD ENTRY DATE
  1966-12-01
SOURCE
  Revista de Neurologia (1966) 114:5 (378-381). Date of Publication: 1966
VOLUME
  114
ISSUE
  5
FIRST PAGE
  378
LAST PAGE
  381
DATE OF PUBLICATION
  1966
ISSN
  0210-0010
ABSTRACT
  Eight days after developing angina with arthralgia in the right elbow a 
28-yr-old woman presented symptoms of acute bilateral 'retrobulbar neuritis' 
with complete blindness, paralytic mydriasis and slight hemiparesis on the 
right side. A few days later a sensory motor flaccid quadriplegia of Cg-C7 
level localization developed rapidly after PEG. The CSF contained 35 cells/ 
mm3, proteins 0.45 g/1 and glucose 1.03 g/1. The optic disks showed soft 
nasal borders. Because of important respiratory disturbances tracheotomy was 
performed allowing assited respiration during a few weeks. Antibiotics, 
hydrocortisone, ACTH and vitamins were administered. A slight improvement 
occurred but pyocyanic infection of bedsores, bronchopneurnonitis and 
purulent pleuritis were responsible for the death of the patient 4.5 mth 
after the onset of the disease. Examination of the CNS revealed atrophy of 
the chiasma and both optic nerves, cerebral edema and a large necrotic focus 
in the cervico-thoracic segment of the spinal cord. Only parts of the later 
alnd dorsal column were spared in the affected segment. Similar necrotic 
foci were also observed in the medulla and under the floor of the 3rd 
ventricle. These necrotic lesions were characterized by numerous macrophages 
without macroglial and lymphocytic reactions. The cerebral edema was 
explained by numerous micro-abscesses with predominant polmorphonuclear 
cells. These disseminated nodular inflammatory lesions due to a preterminal 
septicemia are to be distinguished from the inflammatory reactions in 
perivenous encephalomyelitides and similar demyelinating diseases. (B, 8a).
EMTREE DRUG INDEX TERMS
  antibiotic agent; corticotropin; glucose; hydrocortisone; protein; vitamin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  encephalitis; myelooptic neuropathy; 
EMTREE MEDICAL INDEX TERMS
  abscess; angina pectoris; arthralgia; atrophy; blindness; brain edema; central nervous system; cerebrospinal fluid; death; decubitus; demyelinating disease; elbow; examination; female; hemiparesis; infection; inflammation; macrophage; mydriasis; optic disk; optic nerve; patient; pleura empyema; quadriplegia; respiratory failure; retrobulbar optic neuropathy; septicemia; spinal cord; spine; tracheotomy; 
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007909597
PUI
  L287050262
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02100010&id=doi:&atitle=Clinico-pathological+study+of+devic%27s+optic+neuromyelitis+with+artificially+prolonged+course.+terminal+septic+encephalitis&stitle=Rev.+Neurol.&title=Revista+de+Neurologia&volume=114&issue=5&spage=378&epage=381&aulast=Tommasi&aufirst=M.&auinit=M.&aufull=Tommasi+M.&coden=&isbn=&pages=378-381&date=1966&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1109
TITLE
  CARDIOVASCULAR COMPLICATIONS during ANESTHESIA for a CERVICAL SPINALCORD 
INJURY (Japanese)
AUTHOR NAMES
  Uchida M.; Ishitani H.; Okuda Y.; Kiyohara R.
AUTHOR ADDRESSES
  (Uchida M.; Ishitani H.; Okuda Y.; Kiyohara R.) Dept. of Anesthesiol, Osaka 
Red Cross Hosp., Osaka, Japan.
CORRESPONDENCE ADDRESS
  M. Uchida, Dept. of Anesthesiol, Osaka Red Cross Hosp., Osaka, Japan.
FULL RECORD ENTRY DATE
  1966-12-01
SOURCE
  Japanese Journal of Anesthesiology (1966) 15:8 (12-16). Date of Publication: 
1966
VOLUME
  15
ISSUE
  8
FIRST PAGE
  12
LAST PAGE
  16
DATE OF PUBLICATION
  1966
ISSN
  0021-4892
ABSTRACT
  A 24-yr. -old male was hospitalized with a dislocation of the 6th cervical 
vertebra and a spinal cord injury in the associated area. There was complete 
paralysis of the sensory and most of the motor area below C 5-6 segments on 
the 50th day after the injury. Thoracic respiration had deteriorated. After 
atropinization, he was induced with 150 mg. of thiopentone which gave rise 
to muscletwitching in the pectoral area. SCC infusion produced peripheral 
ischemia for 3 min. The addition of fluothane with N2O oxygen, caused the 
cardiovascular system practically to collapse within 3 min. Carnigen was 
injected and successfully restored cardiac function, but the operation had 
to be postponed until the 75th day. The patient was then tracheotomized and 
anesthesia was maintained with N2O oxygen and a local anesthetic. The 
operation and anesthetic were uneventful. Thiopentone induced twitching and 
hypersensitivity to ACh in denervated patients are discussed. SCC-induced 
ischemia must be caused by a dominant nicotinic action. Nakayama - Tokyo.
EMTREE DRUG INDEX TERMS
  anesthetic agent; halothane; local anesthetic agent; oxilofrine; oxygen; thiopental; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; cardiovascular system; cervical spine; denervation; heart; heart arrest; heart function; hypersensitivity; infusion; injury; ischemia; Japan; male; paralysis; patient; peripheral ischemia; spinal cord injury; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008478601
PUI
  L287130629
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00214892&id=doi:&atitle=CARDIOVASCULAR+COMPLICATIONS+during+ANESTHESIA+for+a+CERVICAL+SPINALCORD+INJURY+%28Japanese%29&stitle=Jap.+J.+Anaesth.&title=Japanese+Journal+of+Anesthesiology&volume=15&issue=8&spage=12&epage=16&aulast=Uchida&aufirst=M.&auinit=M.&aufull=Uchida+M.&coden=&isbn=&pages=12-16&date=1966&auinit1=M&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1110
TITLE
  Emergency surgical care of injuries in mass accidents. Initial medical help 
at the accident site in facial injuries, penetrating injuries of the body 
cavity, injuries of the vertebral column involving the spinal cord
ORIGINAL (NON-ENGLISH) TITLE
  Dringliche chirurgische Versorgung von Verletzten beim Massenunfall. Erste 
ärztliche Hilfe am Unfallort bei Gesichtsverletzungen, penetrierenden 
Veletzungen der Körperhölen, Verletzungen der Wirbelsäule mit Beteiligung 
des Rückenmarks.
AUTHOR NAMES
  Berthold H.; Reichmann J.; Zeumer G.
AUTHOR ADDRESSES
  (Berthold H.; Reichmann J.; Zeumer G.)
CORRESPONDENCE ADDRESS
  H. Berthold,
FULL RECORD ENTRY DATE
  1968-09-04
SOURCE
  Zeitschrift für ärztliche Fortbildung (1966) 60:16 (929-936). Date of 
Publication: 15 Aug 1966
VOLUME
  60
ISSUE
  16
FIRST PAGE
  929
LAST PAGE
  936
DATE OF PUBLICATION
  15 Aug 1966
ISSN
  0044-2178
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  accident; emergency; first aid; injury (surgery); 
EMTREE MEDICAL INDEX TERMS
  abdominal injury (surgery); adult; article; artificial ventilation; child; endotracheal intubation; face injury (surgery); foreign body (surgery); head injury (surgery); heart injury (surgery); human; patient transport; preschool child; rib fracture (surgery); spinal cord injury (surgery); spine injury (surgery); thorax injury (surgery); tracheotomy; 
LANGUAGE OF ARTICLE
  German
MEDLINE PMID
  5998929 (http://www.ncbi.nlm.nih.gov/pubmed/5998929)
PUI
  L88072933
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00442178&id=doi:&atitle=Emergency+surgical+care+of+injuries+in+mass+accidents.+Initial+medical+help+at+the+accident+site+in+facial+injuries%2C+penetrating+injuries+of+the+body+cavity%2C+injuries+of+the+vertebral+column+involving+the+spinal+cord&stitle=Z+Arztl+Fortbild+%28Jena%29&title=Zeitschrift+f%C3%BCr+%C3%A4rztliche+Fortbildung&volume=60&issue=16&spage=929&epage=936&aulast=Berthold&aufirst=H.&auinit=H.&aufull=Berthold+H.&coden=&isbn=&pages=929-936&date=1966&auinit1=H&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1111
TITLE
  Cardiovascular reflexes in tracheostomjsed tetraplegics
AUTHOR NAMES
  Dollfus P.; Frankel H.L.
AUTHOR ADDRESSES
  (Dollfus P.; Frankel H.L.) Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., 
Aylesbury, United Kingdom.
CORRESPONDENCE ADDRESS
  P. Dollfus, Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., Aylesbury, 
United Kingdom.
FULL RECORD ENTRY DATE
  1965-12-01
SOURCE
  Paraplegia (1965) 2:4 (227-235). Date of Publication: 1965
VOLUME
  2
ISSUE
  4
FIRST PAGE
  227
LAST PAGE
  235
DATE OF PUBLICATION
  1965
ISSN
  0031-1758
ABSTRACT
  A patient with acute traumatic tetraplegia associated with severe bleeding 
from multiple peptic 'stress ulcers' is described. He was treated with blood 
transfusions (35 pints in 1 week) but his condition deteriorated after a 
pulmonary embolism and a tracheostomy was performed. Subsequently he had 
periods of cardiac arrest every time his tracheostomy was sucked out. 
Atropine prevented this, and the mechanism of the cardiac arrest is assumed 
to be vago-vagal. The patient died the next day. Seven patients with high 
traumatic spinal cord lesions and tracheostomies (6 cervical, 1 upper 
dorsal) had ECGs performed before, during and after endotracheal suction. No 
arrhythmias developed. The mechanism of the cardiac arrest in this case is 
discussed with particular reference to the association with 'stress ulcers' 
and pulmonary embolism.
EMTREE DRUG INDEX TERMS
  atropine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cardiovascular reflex; 
EMTREE MEDICAL INDEX TERMS
  bleeding; blood transfusion; heart arrest; heart arrhythmia; lung embolism; patient; quadriplegia; spinal cord lesion; stress ulcer; tracheobronchial toilet; tracheostomy; tracheotomy; 
CAS REGISTRY NUMBERS
  atropine (51-55-8, 55-48-1)
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007751187
PUI
  L281121230
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Cardiovascular+reflexes+in+tracheostomjsed+tetraplegics&stitle=Paraplegia&title=Paraplegia&volume=2&issue=4&spage=227&epage=235&aulast=Dollfus&aufirst=P.&auinit=P.&aufull=Dollfus+P.&coden=&isbn=&pages=227-235&date=1965&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1112
TITLE
  Cardiovascular reflexes in tracheostomised tetraplegics
AUTHOR NAMES
  Dollfus P.; Frankel H.L.
AUTHOR ADDRESSES
  (Dollfus P.; Frankel H.L.) Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., 
Aylesbury, United Kingdom.
CORRESPONDENCE ADDRESS
  P. Dollfus, Nat. Spin. Injur. Cent., Stoke Mandeville Hosp., Aylesbury, 
United Kingdom.
FULL RECORD ENTRY DATE
  1965-12-01
SOURCE
  Paraplegia (1965) 2:4 (227-235). Date of Publication: 1965
VOLUME
  2
ISSUE
  4
FIRST PAGE
  227
LAST PAGE
  235
DATE OF PUBLICATION
  1965
ISSN
  0031-1758
ABSTRACT
  A patient with acute traumatic tetraplegia associated with severe bleeding 
from multiple peptic 'stress ulcers' is described. He was treated with blood 
transfusions (35 pints in 1 week) but his condition deteriorated after a 
pulmonary embolism and a tracheostomy was performed. Subsequently he had 
periods of cardiac arrest every time his tracheostomy was sucked out. 
Atropine prevented this, and the mechanism of the cardiac arrest is assumed 
to be vago-vagal. The patient died the next day. Seven patients with high 
traumatic spinal cord lesions and tracheostomies (6 cervical, 1 upper 
dorsal) had ECGs performed before, during and after endotracheal suction. No 
arrhythmias developed. The mechanism of the cardiac arrest in this case is 
discussed with particular reference to the association with 'stress ulcers' 
and pulmonary embolism.
EMTREE DRUG INDEX TERMS
  atropine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cardiovascular reflex; 
EMTREE MEDICAL INDEX TERMS
  bleeding; blood transfusion; heart arrest; heart arrhythmia; lung embolism; patient; quadriplegia; spinal cord lesion; stress ulcer; tracheobronchial toilet; tracheostomy; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007959309
PUI
  L286070242
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=Cardiovascular+reflexes+in+tracheostomised+tetraplegics&stitle=Paraplegia&title=Paraplegia&volume=2&issue=4&spage=227&epage=235&aulast=Dollfus&aufirst=P.&auinit=P.&aufull=Dollfus+P.&coden=&isbn=&pages=227-235&date=1965&auinit1=P&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1113
TITLE
  CARDIOVASCULAR REFLEXES IN TRACHEOSTOMISED TETRAPLEGICS.
AUTHOR NAMES
  Dollfus P.; Frankel H.L.
AUTHOR ADDRESSES
  (Dollfus P.; Frankel H.L.)
CORRESPONDENCE ADDRESS
  P. Dollfus,
FULL RECORD ENTRY DATE
  1965-03-01
SOURCE
  Paraplegia (1965) 59 (227-235). Date of Publication: Mar 1965
VOLUME
  59
FIRST PAGE
  227
LAST PAGE
  235
DATE OF PUBLICATION
  Mar 1965
ISSN
  0031-1758
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drainage; electrocardiography; heart arrest; lung embolism; paraplegia; quadriplegia; reflex; spinal cord injury; stomach ulcer; tracheotomy; wound drainage; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  14261505 (http://www.ncbi.nlm.nih.gov/pubmed/14261505)
PUI
  L80873111
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=CARDIOVASCULAR+REFLEXES+IN+TRACHEOSTOMISED+TETRAPLEGICS.&stitle=Paraplegia&title=Paraplegia&volume=59&issue=&spage=227&epage=235&aulast=Dollfus&aufirst=P.&auinit=P.&aufull=Dollfus+P.&coden=&isbn=&pages=227-235&date=1965&auinit1=P&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1114
TITLE
  AN ALTERNATIVE TECHNIQUE FOR BRONCHIAL ASPIRATION THROUGH A TRACHEOSTOMY.
AUTHOR NAMES
  Cheshire D.J.; Foster K.M.
AUTHOR ADDRESSES
  (Cheshire D.J.; Foster K.M.)
CORRESPONDENCE ADDRESS
  D.J. Cheshire,
FULL RECORD ENTRY DATE
  1964-10-01
SOURCE
  Paraplegia (1964) 60 (141-145). Date of Publication: Oct 1964
VOLUME
  60
FIRST PAGE
  141
LAST PAGE
  145
DATE OF PUBLICATION
  Oct 1964
ISSN
  0031-1758
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  bronchus; drainage; endotracheal intubation; geriatrics; lung disease; paralysis; respiratory failure; spinal cord injury; tracheotomy; wound drainage; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  14224274 (http://www.ncbi.nlm.nih.gov/pubmed/14224274)
PUI
  L80813101
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=AN+ALTERNATIVE+TECHNIQUE+FOR+BRONCHIAL+ASPIRATION+THROUGH+A+TRACHEOSTOMY.&stitle=Paraplegia&title=Paraplegia&volume=60&issue=&spage=141&epage=145&aulast=Cheshire&aufirst=D.J.&auinit=D.J.&aufull=Cheshire+D.J.&coden=&isbn=&pages=141-145&date=1964&auinit1=D&auinitm=J
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1115
TITLE
  Anterior spinal fusion: The operative approaches.
AUTHOR NAMES
  Fang H.S.; Ong G.B.; Hodgson A.R.
AUTHOR ADDRESSES
  (Fang H.S.; Ong G.B.; Hodgson A.R.)
CORRESPONDENCE ADDRESS
  H.S. Fang,
FULL RECORD ENTRY DATE
  1968-08-27
SOURCE
  Clinical orthopaedics and related research (1964) 35 (16-33). Date of 
Publication: 1964 Jul-Aug
VOLUME
  35
FIRST PAGE
  16
LAST PAGE
  33
DATE OF PUBLICATION
  1964 Jul-Aug
ISSN
  0009-921X
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine (surgery); spine fusion; vertebra (surgery); 
EMTREE MEDICAL INDEX TERMS
  anesthesia; article; child; human; postoperative care; premedication; preoperative care; procedures; tracheotomy; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  5889165 (http://www.ncbi.nlm.nih.gov/pubmed/5889165)
PUI
  L88171650
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0009921X&id=doi:&atitle=Anterior+spinal+fusion%3A+The+operative+approaches.&stitle=Clin.+Orthop.+Relat.+Res.&title=Clinical+orthopaedics+and+related+research&volume=35&issue=&spage=16&epage=33&aulast=Fang&aufirst=H.S.&auinit=H.S.&aufull=Fang+H.S.&coden=&isbn=&pages=16-33&date=1964&auinit1=H&auinitm=S
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1116
TITLE
  ASPECTS OF MAJOR INJURY IN THE JOHANNESBURG AFRICAN--A REVIEW OF 300 CASES.
AUTHOR NAMES
  Froman C.
AUTHOR ADDRESSES
  (Froman C.)
CORRESPONDENCE ADDRESS
  C. Froman,
FULL RECORD ENTRY DATE
  1964-05-09
SOURCE
  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 
(1964) 38 (325-328). Date of Publication: 9 May 1964
VOLUME
  38
FIRST PAGE
  325
LAST PAGE
  328
DATE OF PUBLICATION
  9 May 1964
ISSN
  0256-9574
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  abdominal injury; amputation; Black person; Black person; blood vessel; cardiovascular disease; emergency; face injury; fracture; head injury; heart injury; injury; kidney disease; shock; South Africa; spinal cord injury; statistics; thorax injury; tracheotomy; urology; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  14145115 (http://www.ncbi.nlm.nih.gov/pubmed/14145115)
PUI
  L80769280
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=02569574&id=doi:&atitle=ASPECTS+OF+MAJOR+INJURY+IN+THE+JOHANNESBURG+AFRICAN--A+REVIEW+OF+300+CASES.&stitle=S.+Afr.+Med.+J.&title=South+African+medical+journal+%3D+Suid-Afrikaanse+tydskrif+vir+geneeskunde&volume=38&issue=&spage=325&epage=328&aulast=Froman&aufirst=C.&auinit=C.&aufull=Froman+C.&coden=&isbn=&pages=325-328&date=1964&auinit1=C&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1117
TITLE
  RESPIRATORY MANAGEMENT IN ACUTE TRAUMATIC TETRAPLEGIA.
AUTHOR NAMES
  Cheshire D.J.
AUTHOR ADDRESSES
  (Cheshire D.J.)
CORRESPONDENCE ADDRESS
  D.J. Cheshire,
FULL RECORD ENTRY DATE
  1964-03-01
SOURCE
  Paraplegia (1964) 17 (252-261). Date of Publication: Mar 1964
VOLUME
  17
FIRST PAGE
  252
LAST PAGE
  261
DATE OF PUBLICATION
  Mar 1964
ISSN
  0031-1758
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  chloramphenicol; penicillin derivative; penicillin G; trypsin; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  artificial ventilation; bronchoscopy; paraplegia; RESPIRATORS; respiratory failure; spinal cord injury; tracheotomy; ventilator; 
EMTREE MEDICAL INDEX TERMS
  article; 
CAS REGISTRY NUMBERS
  chloramphenicol (134-90-7, 2787-09-9, 56-75-7)
  penicillin G (1406-05-9, 61-33-6)
  trypsin (9002-07-7)
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  14132875 (http://www.ncbi.nlm.nih.gov/pubmed/14132875)
PUI
  L80759064
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00311758&id=doi:&atitle=RESPIRATORY+MANAGEMENT+IN+ACUTE+TRAUMATIC+TETRAPLEGIA.&stitle=Paraplegia&title=Paraplegia&volume=17&issue=&spage=252&epage=261&aulast=Cheshire&aufirst=D.J.&auinit=D.J.&aufull=Cheshire+D.J.&coden=&isbn=&pages=252-261&date=1964&auinit1=D&auinitm=J
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1118
TITLE
  Diagnosis and treatment of closed head trauma
AUTHOR NAMES
  Nishimoto S.; Hirose S.; Miyatake S.; Onoda O.
AUTHOR ADDRESSES
  (Nishimoto S.; Hirose S.; Miyatake S.; Onoda O.) Dept. of Surg., Okayama 
Univ. Med. Sch, Okayama, Japan.
CORRESPONDENCE ADDRESS
  S. Nishimoto, Dept. of Surg., Okayama Univ. Med. Sch, Okayama, Japan.
FULL RECORD ENTRY DATE
  1963-12-01
SOURCE
  Surgery (1963) 25:9 (915-922). Date of Publication: 1963
VOLUME
  25
ISSUE
  9
FIRST PAGE
  915
LAST PAGE
  922
DATE OF PUBLICATION
  1963
ISSN
  0039-6060
ABSTRACT
  Out of 86 patients hospitalized and treated for head injury in 1 yr, 17% 
complained of a heavy feeling of the head and 16% complained of an impaired 
memory. According to Araki's classification of the sequelae of head trauma, 
50% belonged to type II and 34.9% to type III. Six patients complained of 
retrograde amnesia, which lasted several minutes in 4 cases and over 3 hr. 
in 1 severe case. The traumatic force was most frequently directed to the 
anterior or posterior part of the skull and was applied to the frontal and 
occipital region. The cerebral nerves were paralysed in 12 patients. The 
degree of cerebral damage was marked in types I, II, VI and VII of head 
trauma, especially in type II. The onset of cerebral damage was markedly 
delayed in patients without intracranial hemorrhage. The curability of late 
trauma was better than that of recent trauma. Spinal puncture was performed 
3 hr. after trauma in 44 patients, but the general condition was not 
markedly disturbed in any of them. The severity of the head trauma was 
related to the red blood cell count of the CSP, but not to the pressure of 
the CSF. The CSF pressure started to increase and its color became 
xanthochromic, as seen after craniotomy, 3 days after trauma. The clinical 
symptoms were effectively improved after the aspiration of the hemorrhagic 
CSF. Generally, the body temperature was elevated to a level of 37-39° C. on 
the first postoperative day and then gradually decreased. Six patients with 
type IH head trauma and bronchial stenosis were successfully treated by 
tracheotomy and 3 died of respiratory paralysis.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diagnosis; head injury; 
EMTREE MEDICAL INDEX TERMS
  aspiration; body temperature; brain damage; brain hemorrhage; bronchus stenosis; cerebrospinal fluid; cerebrospinal fluid pressure; classification; color; craniotomy; diaphragm paralysis; erythrocyte count; general condition; injury; memory; nerve; patient; puncture; retrograde amnesia; skull; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007938368
PUI
  L281224155
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00396060&id=doi:&atitle=Diagnosis+and+treatment+of+closed+head+trauma&stitle=Surgery&title=Surgery&volume=25&issue=9&spage=915&epage=922&aulast=Nishimoto&aufirst=S.&auinit=S.&aufull=Nishimoto+S.&coden=&isbn=&pages=915-922&date=1963&auinit1=S&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1119
TITLE
  Anaesthesia for operations on the spinal cord and the vertebral column
AUTHOR NAMES
  Kapustin S.M.; Raevskii V.P.
AUTHOR ADDRESSES
  (Kapustin S.M.; Raevskii V.P.) A. L. Polenov Inst. of Neurosurg., Leningrad, 
Russian Federation.
CORRESPONDENCE ADDRESS
  S.M. Kapustin, A. L. Polenov Inst. of Neurosurg., Leningrad, Russian 
Federation.
FULL RECORD ENTRY DATE
  1963-12-01
SOURCE
  Vopr. Neirokhir. (1963) 3 (20-24). Date of Publication: 1963
VOLUME
  3
FIRST PAGE
  20
LAST PAGE
  24
DATE OF PUBLICATION
  1963
ABSTRACT
  For operations of the vertebral column and the spinal cord, general 
anesthesia was used in 83 patients and local anesthesia in 17. There were no 
complications from the anesthesia. For endotracheal anesthesia, nitrous 
oxide and oxygen were used in combination with intravenous relaxants and 
controlled breathing. In patients with injury to the cervical spine a 
tracheotomy was carried out, through which the endotracheal anesthesia was 
administered. The premedication included antihistaminies, analgesics and 
parasympathicolytic drugs. In operations on the thoracic part of the spine, 
the ECG is an important method of control. Tachycardia and slight changes in 
the T-wave were frequently observed. When the patient's condition 
deteriorated, the S-wave became deeper, which pointed to increasing cardiac 
weakness. Marked changes in the venous pressure, especially its rise, were 
regarded as signs of incipient haemodynamic disturbances. The venous 
pressure remained most stable when operation was carried out under 
endotracheal anesthesia. Good results were achieved in the postoperative 
period by using anesthesia in the analgesia stage.
EMTREE DRUG INDEX TERMS
  analgesic agent; cholinergic receptor blocking agent; nitrous oxide; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; spinal cord; spine; 
EMTREE MEDICAL INDEX TERMS
  analgesia; breathing; cervical spine; electrocardiogram; general anesthesia; injury; local anesthesia; patient; postoperative period; premedication; T wave; tachycardia; tracheotomy; venous pressure; weakness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008613035
PUI
  L281492852
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Anaesthesia+for+operations+on+the+spinal+cord+and+the+vertebral+column&stitle=Vopr.+Neirokhir.&title=&volume=3&issue=&spage=20&epage=24&aulast=Kapustin&aufirst=S.M.&auinit=S.M.&aufull=Kapustin+S.M.&coden=&isbn=&pages=20-24&date=1963&auinit1=S&auinitm=M
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1120
TITLE
  Tracheostomy in wounds and diseases of the brain and spinal cord.
AUTHOR NAMES
  Kalitkin K.N.
AUTHOR ADDRESSES
  (Kalitkin K.N.)
CORRESPONDENCE ADDRESS
  K.N. Kalitkin,
FULL RECORD ENTRY DATE
  1962-09-01
SOURCE
  Voprosy neǐrokhirurgii (1962) 26 (54-55). Date of Publication: 1962 Sep-Oct
VOLUME
  26
FIRST PAGE
  54
LAST PAGE
  55
DATE OF PUBLICATION
  1962 Sep-Oct
ISSN
  0042-8817
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; BRAIN INJURY, ACUTE; spinal cord; spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  Russian
MEDLINE PMID
  14030329 (http://www.ncbi.nlm.nih.gov/pubmed/14030329)
PUI
  L80631279
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00428817&id=doi:&atitle=Tracheostomy+in+wounds+and+diseases+of+the+brain+and+spinal+cord.&stitle=Vopr+Neirokhir&title=Voprosy+ne%C7%90rokhirurgii&volume=26&issue=&spage=54&epage=55&aulast=Kalitkin&aufirst=K.N.&auinit=K.N.&aufull=Kalitkin+K.N.&coden=&isbn=&pages=54-55&date=1962&auinit1=K&auinitm=N
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1121
TITLE
  Tracheostomy in wounds and diseases of the brain and spinal cord.
AUTHOR NAMES
  Kalitkin K.N.
AUTHOR ADDRESSES
  (Kalitkin K.N.)
CORRESPONDENCE ADDRESS
  K.N. Kalitkin,
FULL RECORD ENTRY DATE
  1962-09-01
SOURCE
  Voprosy neǐrokhirurgii (1962) 26 (54-55). Date of Publication: 1962 Sep-Oct
VOLUME
  26
FIRST PAGE
  54
LAST PAGE
  55
DATE OF PUBLICATION
  1962 Sep-Oct
ISSN
  0042-8817
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  brain injury; BRAIN INJURY, ACUTE; spinal cord; spinal cord injury; tracheostomy; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  Russian
MEDLINE PMID
  13961949 (http://www.ncbi.nlm.nih.gov/pubmed/13961949)
PUI
  L80602685
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00428817&id=doi:&atitle=Tracheostomy+in+wounds+and+diseases+of+the+brain+and+spinal+cord.&stitle=Vopr+Neirokhir&title=Voprosy+ne%C7%90rokhirurgii&volume=26&issue=&spage=54&epage=55&aulast=Kalitkin&aufirst=K.N.&auinit=K.N.&aufull=Kalitkin+K.N.&coden=&isbn=&pages=54-55&date=1962&auinit1=K&auinitm=N
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1122
TITLE
  The epidemic of poliomyelitis in croatia in 1960
AUTHOR NAMES
  Fališevac J.; Rulnjević J.; Hirzler R.
AUTHOR ADDRESSES
  (Fališevac J.; Rulnjević J.; Hirzler R.)
FULL RECORD ENTRY DATE
  1961-12-01
SOURCE
  Lijecnicki vjesnik (1961) 83:6 (567-583). Date of Publication: 1961
VOLUME
  83
ISSUE
  6
FIRST PAGE
  567
LAST PAGE
  583
DATE OF PUBLICATION
  1961
ISSN
  0024-3477
ABSTRACT
  Of 234 paralytic cases, 79.4% were in children under 4 yr. of age. In the 
Zagreb area, where since 1958 the majority of young children have been 
immunized with Salk vaccine, the percentage of cases was much lower than in 
the previous epidemic (1953) and the incidence had shifted to the older 
children and adult age groups, in which the percentage of immunized subjects 
was lower. The patients included 19 children, who had been immunized with 
combined DPT vaccine 4-30 days previously; in 10 of them only the inoculated 
limb was paralysed. 183 cases had spinal (28 with respiratory failure), 20 
bulbar and 31 bulbospinal form of poliomyelitis. Bulbar involvement occurred 
in adults and young children. It was not possible to estimate the number of 
cases with 'aparalytic' or encephalitic forms of poliomyelitis, since the 
polio epidemic was accompanied by high incidence of serous meningitis and 
meningoencephalitis syndromes caused by other enteroviruses and other 
agents; for the same reason it is not possible to say whether in all cases 
the paralytic disease was due to polioviruses. Specific diagnostic methods 
were used in only a small number of cases; they revealed that all but one of 
the isolated and identified cytopathogenic agents were polioviruses, mainly 
type 1. Serological tests were in agreement with these findings. Treatment 
was along generally adopted lines. In 26 of cases with life-threatening 
poliomyelitis artificial respiration was applied, in 2 tracheotomy was 
performed and in a further 18 cases both methods were used. Of the 234 
patients 23 died, twice as many as for Croatia as a whole. The reason for 
this high fatality rate was the concentration of almost all severe cases 
from Croatia and a part of Bosnia in the respiratory centre of this 
hospital. In the majority of fatal cases death occurred within the first 5 
days after the onset of paralysis. In 21 cases necropsy was performed. In 6 
of them the cause of death was probably damage to the vital centres of the 
CNS, in 7 extracerebral complications, and in 8 both causes acting together, 
were responsible. At necropsy the spinal cord and medulla oblongata were 
involved in all 21 cases, the cerebellum in 14, the basal ganglia in 17, the 
cerebrum in 11 and the leptomeninges in 20 cases. Lesions of the higher 
regions of the CNS were found in this epidemic more frequently than in the 
previous one, in 1953, the only epidemic in Croatia studied in more detail 
from the pathological point of view. Myocarditis was found in 4, and 
pneumonia in 7 necropsies, much less frequently than in the epidemic of 
1953.
EMTREE DRUG INDEX TERMS
  diphtheria pertussis tetanus vaccine; poliomyelitis vaccine; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Croatia; epidemic; poliomyelitis; 
EMTREE MEDICAL INDEX TERMS
  adult; artificial ventilation; autopsy; basal ganglion; brain; cause of death; central nervous system; cerebellum; child; death; diagnostic procedure; Enterovirus; epidemiology; fatality; groups by age; hospital; limb; medulla oblongata; meningitis; meningoencephalitis; myocarditis; paralysis; patient; pneumonia; Poliomyelitis virus; respiratory failure; serology; spinal cord; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007702987
PUI
  L281073030
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00243477&id=doi:&atitle=The+epidemic+of+poliomyelitis+in+croatia+in+1960&stitle=Lijecn.+Vjesn.&title=Lijecnicki+vjesnik&volume=83&issue=6&spage=567&epage=583&aulast=Fali%C5%A1evac&aufirst=J.&auinit=J.&aufull=Fali%C5%A1evac+J.&coden=&isbn=&pages=567-583&date=1961&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1123
TITLE
  Three rare cases of respiratory stenosis (Russian)
AUTHOR NAMES
  Katsnelson E.N.
AUTHOR ADDRESSES
  (Katsnelson E.N.) Dept. of Oto -Rhino -Laryng, Postgrad. Med.Inst, 
Leningrad.
CORRESPONDENCE ADDRESS
  E.N. Katsnelson, Dept. of Oto -Rhino -Laryng, Postgrad. Med.Inst, Leningrad.
FULL RECORD ENTRY DATE
  1961-12-01
SOURCE
  Vopr. Obshch. Klinicheskoi Otorinolarlngo Logii (Sborn.Trud. 
Kaf.Oto-Rino-Laring. Len.Inst.Usoversh. Vrach.) (1961) (253-256). Date of 
Publication: 1961
FIRST PAGE
  253
LAST PAGE
  256
DATE OF PUBLICATION
  1961
ABSTRACT
  Three cases of stenotic breathing of unusual aetiology are cited: (1) A 
54-year-old male patient suffered from a small polypus of the larynx, not 
manifested clinically and not causing embarrassment to breathing. Renal 
disease and cardiac insufficiency brought about the development of laryngeal 
oedema. A secondary inflammatory process and necrosis appearing in the area 
of the polypus caused laryngeal stenosis which necessitated tracheotomy. (2) 
A 25-year-old male patient developed stenotic breathing following azotaemia, 
caused by disease of the kidneys (secondary granular kidney, right-sided 
hydronephrosis, nephrolithiasis). (3) A 30-year-old male patient was 
troubled with stenotic breathing caused by a lesion of the spinal cord, with 
paralysis of the muscles of thorax and diaphragm (traumatic origin).
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  stenosis; 
EMTREE MEDICAL INDEX TERMS
  breathing; diaphragm; etiology; heart failure; hydronephrosis; inflammation; kidney; kidney disease; larynx; larynx edema; larynx stenosis; male; muscle; necrosis; nephrolithiasis; paralysis; patient; spinal cord; thorax; tracheotomy; uremia; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007850402
PUI
  L281177254
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Three+rare+cases+of+respiratory+stenosis+%28Russian%29&stitle=Vopr.+Obshch.+Klinicheskoi+Otorinolarlngo+Logii+%28Sborn.Trud.+Kaf.Oto-Rino-Laring.+Len.Inst.Usoversh.+Vrach.%29&title=&volume=&issue=&spage=253&epage=256&aulast=Katsnelson&aufirst=E.N.&auinit=E.N.&aufull=Katsnelson+E.N.&coden=&isbn=&pages=253-256&date=1961&auinit1=E&auinitm=N
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1124
TITLE
  The circulatory effects of acute respiratory failure: With special reference 
to acute cor pulmonale
AUTHOR NAMES
  Lee G.D.J.
AUTHOR ADDRESSES
  (Lee G.D.J.) Unit. Oxford Hosps., Dept. of the Regius Med. Dept., Radcliffe 
Infirm., Oxford, United Kingdom.
CORRESPONDENCE ADDRESS
  G.D.J. Lee, Unit. Oxford Hosps., Dept. of the Regius Med. Dept., Radcliffe 
Infirm., Oxford, United Kingdom.
FULL RECORD ENTRY DATE
  1961-12-01
SOURCE
  Postgraduate Medical Journal (1961) 37:423 (31-42). Date of Publication: 
1961
VOLUME
  37
ISSUE
  423
FIRST PAGE
  31
LAST PAGE
  42
DATE OF PUBLICATION
  1961
ISSN
  0032-5473
ABSTRACT
  The causes of acute respiratory failure may be classified as: (1) those due 
to extra-pulmonary causes (injuries to the brain, intoxications), 
interference to nerve supply to the muscles of respiration (polio, high 
spinal cord lesions) and various disorders of the chest wall (fractures, 
deformities); (2) those caused by parenchymal disorders of the lung; and (3) 
obstructive pulmonary vascular disease. The functional results are hypoxia, 
hypercapnoea or both. These changes in gases result in changes in peripheral 
circulation, with increased cerebral blood flow, contraction of capillaries 
of the periphery with increased central venous pressure and pulmonary 
arterial vasoconstriction. The exact effects on renal circulation are more 
obscure. Hypoxia produced increase both in heart rate and in stroke volume. 
Fall in cardiac output in relation to failure from cor pulmonale signifies a 
late stage of the process. The author relates a steep rise in hospital 
admissions and in mortality to the influenza epidemic of 1957-1958 which 
precipitated both respiratory failure and acute cor pulmonale in patients 
with emphysema. Twenty per cent of all patients admitted with emphysema or 
related conditions died; 39% of those showing evidence of right heart 
failure died, and 74% of all deaths occurred within 7 days of admission. 
Treatment consists of oxygen (usually no higher than 25-30%), broad spectrum 
antibiotics, tracheostomy in bad cases, digitalization. Sedation is harmful; 
phlebotomy in patients with well-maintained cardiac output is often 
dangerous. Intermittent positive pressure devices are apt to raise the 
general intrathoracic pressure and hence impede venous return to the heart. 
Tracings from patients indicate that this is a real result of the (improper) 
use of such devices.
EMTREE DRUG INDEX TERMS
  antibiotic agent; oxygen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  acute respiratory failure; cor pulmonale; 
EMTREE MEDICAL INDEX TERMS
  brain; brain blood flow; capillary; central venous pressure; death; deformity; devices; digitalization; emphysema; epidemic; epithelium; fracture; gas; heart; heart output; heart rate; heart right ventricle failure; heart stroke volume; hospital admission; hypoxia; influenza; injury; innervation; intoxication; kidney circulation; lung; mortality; muscle; patient; peripheral circulation; phlebotomy; poliomyelitis; respiratory failure; sedation; smoking; spinal cord lesion; thorax pressure; thorax wall; tracheostomy; vascular disease; vasoconstriction; venous return; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007561693
PUI
  L280944787
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00325473&id=doi:&atitle=The+circulatory+effects+of+acute+respiratory+failure%3A+With+special+reference+to+acute+cor+pulmonale&stitle=Postgrad.+Med.+J.&title=Postgraduate+Medical+Journal&volume=37&issue=423&spage=31&epage=42&aulast=Lee&aufirst=G.D.J.&auinit=G.D.J.&aufull=Lee+G.D.J.&coden=&isbn=&pages=31-42&date=1961&auinit1=G&auinitm=D.J.
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1125
TITLE
  Stabilization of the collapsing spine
AUTHOR NAMES
  Garrett A.L.; Perry J.; Nickel V.L.
AUTHOR ADDRESSES
  (Garrett A.L.; Perry J.; Nickel V.L.) Dept. of Orthop. Surg., Poliomyelitis 
Clin. Study Cent., Rancho los Amigos Hosp., Downey, CA, United States.
CORRESPONDENCE ADDRESS
  A.L. Garrett, Dept. of Orthop. Surg., Poliomyelitis Clin. Study Cent., 
Rancho los Amigos Hosp., Downey, CA, United States.
FULL RECORD ENTRY DATE
  1961-12-01
SOURCE
  J. Bom Jt Surg. (1961) 43:4 (474-484). Date of Publication: 1961
VOLUME
  43
ISSUE
  4
FIRST PAGE
  474
LAST PAGE
  484
DATE OF PUBLICATION
  1961
ABSTRACT
  The purpose of the paper is to demonstrate the value of stability of the 
spine in patients with paralysed trunk muscles. Scoliosis deformity as such 
is stated not to be the essential factor decreasing functional ability. The 
operative procedure was a Hibbs type fusion with excision of the facet 
joints and with the addition of bone. For immobilization a body cast 
connected with a halo device fixed to the skull bones was applied in many 
instances. All fusions involved at least thirteen segments, the longest 
reaching from the occiput to the fourth lumbar vertebra. The series includes 
only patients with considerable trunk instability, the muscles of the back 
rating between poor and zero. The safety of these major surgical operations 
on patients with major respiratory deficit is striking. Thirty-one patients 
had vital capacities below 60%. Tracheotomy was performed prior to 
operation. The operative mortality was nil. Follow-up results 1 to 1.5 yr. 
after operation on 38 patients, ranging in age between 4 and 48 yr., are 
given. Extremity function endurance and respiratory function were tested and 
generally found to be improved. Patients with poor body balance but with 
preserved function of the lower extremities had the greatest benefit from 
fusion. Some patients, before the operation unable even to sit and stand 
without assistance, got stability enough from fusion of the spine to be 
capable of performing that function unaided.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  spine; 
EMTREE MEDICAL INDEX TERMS
  bone; deformity; devices; endurance; excision; follow up; forced expiratory volume; immobilization; leg; lumbar vertebra; muscle; paralysis; patient; respiratory function; safety; scoliosis; skeletal muscle; skull; surgery; surgical mortality; tracheotomy; vital capacity; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007614297
PUI
  L280994102
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Stabilization+of+the+collapsing+spine&stitle=J.+Bom+Jt+Surg.&title=&volume=43&issue=4&spage=474&epage=484&aulast=Garrett&aufirst=A.L.&auinit=A.L.&aufull=Garrett+A.L.&coden=&isbn=&pages=474-484&date=1961&auinit1=A&auinitm=L
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1126
TITLE
  Total cervical-spine fusion for neck paralysis
AUTHOR NAMES
  Perry J.; Nickel V.L.
AUTHOR ADDRESSES
  (Perry J.; Nickel V.L.)
FULL RECORD ENTRY DATE
  1959-12-01
SOURCE
  J. Bone Jt Surg. (1959) 41 A:1 (37-60). Date of Publication: 1959
VOLUME
  41 A
ISSUE
  1
FIRST PAGE
  37
LAST PAGE
  60
DATE OF PUBLICATION
  1959
ABSTRACT
  The cases concerned were cases of severe paralysis, mostly as a sequela of 
poliomyelitis. Among the 22 cases considered, fixation with inclusion of the 
skull was carried out 10 times. The indication as to how far the fusion has 
to be extended depends on an accurate examination of the 4 muscle groups and 
the degrees of preserved function: The flexors and extensors of the head and 
the flexors and extensors of the neck. The procedure is particularly 
indicated for those patients,who in addition to the instability of the 
head,suffer from disturbances of breathing, swallowing and speech. The 
operation is carried out with the aid of a particular extension apparatus, 
the halo traction apparatus, which is attached to the cranial bones with 
screws and head band. Intubation anaesthesia is administered via a 
tracheotomy. Particular difficulties are attached to the stabilizing of the 
suboccipital region. The technique consists in decortication of the 
vertebral arches and the small vertebral articulations using the chip 
technique of Hibbs. If the fusion area did not extend proximal to the second 
cervical vertebra, no additional bone was used. Suboccipitally. autoplastic 
chips from the posterior portion of the ilium were used. The traction is 
maintained for 3 months.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spine; neck; paralysis; spine fusion; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; bone; brace; breathing; decortication; examination; iliac bone; intubation; muscle; patient; poliomyelitis; scoliosis; skull; speech; swallowing; thorax surgery; tracheotomy; traction therapy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007662778
PUI
  L281032821
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Total+cervical-spine+fusion+for+neck+paralysis&stitle=J.+Bone+Jt+Surg.&title=&volume=41+A&issue=1&spage=37&epage=60&aulast=Perry&aufirst=J.&auinit=J.&aufull=Perry+J.&coden=&isbn=&pages=37-60&date=1959&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1127
TITLE
  Injuries to the cervical cord. fundamental factors in treatment and 
rehabilitation
AUTHOR NAMES
  White J.C.
AUTHOR ADDRESSES
  (White J.C.)
CORRESPONDENCE ADDRESS
  J.C. White, Boston, MA, United States.
FULL RECORD ENTRY DATE
  1959-12-01
SOURCE
  J. Bone Jt Surg. (1959) 41:1 (11-15). Date of Publication: 1959
VOLUME
  41
ISSUE
  1
FIRST PAGE
  11
LAST PAGE
  15
DATE OF PUBLICATION
  1959
ABSTRACT
  The first essential in injuries to the cervical vertebrae is protection 
against increasing damage to the spinal cord. Cranial traction by means of 
tongs should be applied in every quadriplegic patient, even if no fracture 
of dislocation is apparent. To prevent critical respiratory embarrassment, 
oxygen administration, tracheotomy, and a snug swathe applied to the lower 
ribe can be helpful. It ia recommended to delay operation until the patient 
ia recovering from spinal shock, with a systolic blood pressure over 100 and 
a vital capacity of over 1000 ml. While complete spinal recovery rarely 
results, when it would not have taken place spontaneously, experience has 
shown that operation performed after the first critical days is relatively 
safe and has the following advantages: (1) protection in penetrating wounds 
against meningitis resulting from septic fistulae; (2) reduction of 
radicular pain from compression of emerging roots of the brachial plexus; 
(3) recovery of compressed plexus roots above the level of spinal 
tranaection. Spinal fusion allows earlier movement and institution of the 
rehabilitation programme. During the first critical month, expert nursing is 
required in order to help prevent bed-sores, hypostatic pneumonia, 
hypoproteinaemia, and malnutrition. Tidal drainage and affective bowel 
training can restore satisfactory automatic evacuation through spinal reflex 
mechanisms. Also helpful are orthopaedic surgical procedures for stabilizing 
the thoracolumbar spine, and the transplantation of tendons to finger 
flexors and extensors.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cervical spinal cord; injury; rehabilitation; 
EMTREE MEDICAL INDEX TERMS
  bladder and bowel management; brachial plexus; cervical spine; compression; decubitus; fistula; forced expiratory volume; fracture; hypoproteinemia; malnutrition; meningitis; nursing; oxygen therapy; patient; penetrating trauma; pneumonia; protection; radicular pain; spinal cord; spinal reflex; spine fusion; surgical technique; systolic blood pressure; tendon; thoracolumbar spine; tracheotomy; traction therapy; transplantation; vital capacity; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007663057
PUI
  L281033100
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Injuries+to+the+cervical+cord.+fundamental+factors+in+treatment+and+rehabilitation&stitle=J.+Bone+Jt+Surg.&title=&volume=41&issue=1&spage=11&epage=15&aulast=White&aufirst=J.C.&auinit=J.C.&aufull=White+J.C.&coden=&isbn=&pages=11-15&date=1959&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1128
TITLE
  Neurosurgery in old age and modern anaesthesia
ORIGINAL (NON-ENGLISH) TITLE
  Alters-neurochirurgie und moderne narkose
AUTHOR NAMES
  Wüllenweber R.
AUTHOR ADDRESSES
  (Wüllenweber R.) Neurochir. Univ.-Klin., Bonn, Germany.
CORRESPONDENCE ADDRESS
  R. Wüllenweber, Neurochir. Univ.-Klin., Bonn, Germany.
FULL RECORD ENTRY DATE
  1958-12-01
SOURCE
  Anaesthesist (1958) 7:11 (333-337). Date of Publication: 1958
VOLUME
  7
ISSUE
  11
FIRST PAGE
  333
LAST PAGE
  337
DATE OF PUBLICATION
  1958
ISSN
  0003-2417
ABSTRACT
  In the above clinic, 165 major neurosurgical interventions were performed 
during the period 1956/1957 on patients aged 60-75. Death within 4 weeks was 
recorded as early death; this group included secondary causes of death such 
as embolism, infection, etc. The best results were obtained in extradural 
operations on the spinal cord (i i% mortality), on the cranium (trigeminus, 
aneurysms, angiomata, 5-7% mortality) and in intradural operations on the 
spinal cord (about 10% mortality), but intradural operations on the brain 
were considerably less favourable (tumours, haematomata, abscesses, 33-40% 
mortality). The least favourable results were obtained in hypophyseal 
adenoma and craniopharyngeoma; these conditions are at present given only 
palliative therapy, the former with radioactive gold seeds, and the latter 
by puncture evacuation of the cysts, both under X-ray control. Cerebral 
oedema is of decisive importance as a factor leading to complications and 
death (postoperative incarceration !). Other such factors include intradural 
haemorrhage and circulatory collapse. The over-all mortality very closely 
approaches that in younger patients. Only modern anaesthesia has been used 
since 1952 (this means: block of the ANS and controlled hypotension). The 
results remained unaltered, but indications were considerably extended (81 
cranial interventions as against 18 previously; 7.2% over 6p yr. old as 
against 1.5% previously). Local anaesthesia was entirely abandoned in view 
of frequent cerebral oedema. The trachea was invariably intubated, as this 
is no longer possible once the operation has commenced (position, asepsis). 
Muscle relaxation interferes with respiratory control unless intubation is 
performed. All cases were given anaesthesia using the half-open system, to 
avoid the necessity of breathing against resistance. In N1O anaesthesia, the 
O1 supply is often insufficient for aged subjects; this is improved by 
'forced expiration', particularly in patients with emphysema. Postoperative 
oxygen administration is always continued for several days. Controlled 
hypotension is indispensable in the case of angiomas or highly vascularized 
tumours. An arterial pressure decrease to below 70 mm. Hg in hypertensive 
subjects should be avoided. Postoperative hypotension against cerebral 
oedema is effective only if sustained (in which case it is hazardous in old 
age). Hypotension to the point of a decrease in venous pressure may cause 
circulatory collapse. It is therefore impossible to control cerebral oedema 
by hypotension in the aged. After-haemorrhage, however, can be readily 
controlled by mild hypotension for a maximum of 32 hr. Hibernation is only 
too often followed by circulatory collapse in the aged. Tracheotomy is 
becoming increasingly important as an aid in the prevention of hypostatic 
pneumonia.
EMTREE DRUG INDEX TERMS
  gold 198; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  anesthesia; neurosurgery; senescence; 
EMTREE MEDICAL INDEX TERMS
  abscess; aged; aneurysm; angioma; arterial pressure; asepsis; bleeding; brain; breathing; craniopharyngioma; cyst; death; edema; embolism; emphysema; forced expiration; hibernation; hypophysis adenoma; hypotension; induced hypotension; infection; intubation; local anesthesia; mortality; muscle relaxation; outpatient department; oxygen therapy; palliative therapy; patient; plant seed; pneumonia; prevention; puncture; respiration control; shock; skull; spinal cord; trachea; tracheotomy; trigeminal nerve; venous pressure; X ray; 
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008304558
PUI
  L281384461
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00032417&id=doi:&atitle=Neurosurgery+in+old+age+and+modern+anaesthesia&stitle=Anaesthetist&title=Anaesthesist&volume=7&issue=11&spage=333&epage=337&aulast=W%C3%BCllenweber&aufirst=R.&auinit=R.&aufull=W%C3%BCllenweber+R.&coden=&isbn=&pages=333-337&date=1958&auinit1=R&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1129
TITLE
  INDICATIONS and TECHNIQUE of TRACHEOSTOMY in RESPIRATORY SYNDROMES
ORIGINAL (NON-ENGLISH) TITLE
  Indications et technique de la trachéostomie dans les syndromes 
respiratoires
AUTHOR NAMES
  Despons J.
AUTHOR ADDRESSES
  (Despons J.) Dept. de Laryngol., Cent, de Réanimation, Bordeaux.
CORRESPONDENCE ADDRESS
  J. Despons, Dept. de Laryngol., Cent, de Réanimation, Bordeaux.
FULL RECORD ENTRY DATE
  1958-12-01
SOURCE
  Revue de laryngologie, d'otologie et de rhinologie (1919) (1958) 79:11 
(1169-1222). Date of Publication: 1958
VOLUME
  79
ISSUE
  11
FIRST PAGE
  1169
LAST PAGE
  1222
DATE OF PUBLICATION
  1958
ISSN
  0035-1334
ABSTRACT
  After an historical outline, an extensive study is made of the indications 
of tracheotomy, which at present should not be considered as a palliative 
operation, a make shut in cases of asphyxia, but as a veritable method of 
treatment taking its place among the modern methods of resuscitation. The 
principal indications studied include the following: (1) Respiratory 
syndromes of nervous origin, which comprise: bulbar poliomyelitis, 
Guillain-Barre syndrome, various forms of polioencephalitis, comas, 
cerebrovascular syndromes and tetanus. (2) Respiratory syndromes of 
traumatic and surgical origin: cranial and spinal traumatisms, thoracic 
traumatisms, accidents due to anaesthesia, drowning, sequelae of thoracic 
operations, etc. A very complete clinical and physiopathological study of 
the respiratory syndromes precedes the detailed description of the technique 
of tracheotomy, its possible complications and its results. Decroix Paris 
(XV, 50).
EMTREE MEDICAL INDEX TERMS
  accident; acute respiratory tract disease; anesthesia; asphyxia; cerebrovascular disease; coma; drowning; France; general aspects of disease; Guillain Barre syndrome; poliomyelitis; resuscitation; tetanus; thorax surgery; tracheotomy; 
LANGUAGE OF ARTICLE
  French
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008067196
PUI
  L281268805
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00351334&id=doi:&atitle=INDICATIONS+and+TECHNIQUE+of+TRACHEOSTOMY+in+RESPIRATORY+SYNDROMES&stitle=Rev.+Laryng.&title=Revue+de+laryngologie%2C+d%27otologie+et+de+rhinologie+%281919%29&volume=79&issue=11&spage=1169&epage=1222&aulast=Despons&aufirst=J.&auinit=J.&aufull=Despons+J.&coden=&isbn=&pages=1169-1222&date=1958&auinit1=J&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1130
TITLE
  Bulbar spinal poliomyelitis complicating pregnancy at term
AUTHOR NAMES
  Pvatt H.M.; Yim B.; West W.L.
AUTHOR ADDRESSES
  (Pvatt H.M.; Yim B.; West W.L.)
FULL RECORD ENTRY DATE
  1958-12-01
SOURCE
  New England journal of medicine (Print) (1958) 258:3 (130-131). Date of 
Publication: 1958
VOLUME
  258
ISSUE
  3
FIRST PAGE
  130
LAST PAGE
  131
DATE OF PUBLICATION
  1958
ISSN
  0028-4793
ABSTRACT
  The first case reported in this article is that of a 26-year-old paia-1, 
gravida-2, with progressing bulbar respiratory paralytic poliomyelitis. 
Admission date was 3 weeks before expected delivery. Tracheotomy was 
performed and the patient was placed in a Drinker respirator. Within 12 hr. 
all extremities and the chest were paralysed. Twenty-four hours after 
admission a low-segment caesarean section was performed. A viable but 
cyanotic male infant was delivered. The mother had a stormy convalescence, 
and she was gradually weaned away from the respirator into the rocking bed. 
The quadriplegia did not improve. The second case was that of a 23-year-old 
para-3, gravida-4, who was 35 weeks pregnant. She was admitted with 
paralysis of one arm and leg. Three days after admission, respiratory 
difficulty developed. Tracheotomy was performed and the patient was placed 
in the respirator. The following day, a caesarean section was performed, and 
a 2,230 g. viable infant was delivered. The mother did well and 12 days 
later weaning from the respirator was started and she began to tolerate 
plugging of the tracheotomy. It is emphasized that with paralysis of the 
intercostal, diaphragmatic and abdominal muscles, an intra-abdominal mass, 
such as a foetus, actually reduces ventilation when the patient is in the 
tank respirator Thus early delivery enhances mechanical ventilation by the 
lank and contributes to the survival of mother and infant.
EMTREE DRUG INDEX TERMS
  nitrogen; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  poliomyelitis; pregnancy; 
EMTREE MEDICAL INDEX TERMS
  abdominal mass; abdominal wall musculature; air conditioning; arm; artificial ventilation; boy; cesarean section; convalescence; diaphragm paralysis; fetus (anatomy); infant; leg; mother; paralysis; patient; quadriplegia; survival; thorax; tracheotomy; ventilator; weaning; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2008857715
PUI
  L281544305
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00284793&id=doi:&atitle=Bulbar+spinal+poliomyelitis+complicating+pregnancy+at+term&stitle=New+Engl.+J.+Med.&title=New+England+journal+of+medicine+%28Print%29&volume=258&issue=3&spage=130&epage=131&aulast=Pvatt&aufirst=H.M.&auinit=H.M.&aufull=Pvatt+H.M.&coden=&isbn=&pages=130-131&date=1958&auinit1=H&auinitm=M
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1131
TITLE
  Recovery from a severe asthmatic state following tracheotomy, endotracheal 
respiration, procaine block of spinal nerve roots & curarization.
ORIGINAL (NON-ENGLISH) TITLE
  Guérison d'un état de mal asthmatique gravissime par trachéotomie, 
respiration endotrachéale, procaïnisation médullo-radiculaire et 
curarisation.
AUTHOR NAMES
  Mollaret P.; Turiaf J.; Bastin R.; Goulon M.; Lissac J.; Cophignon J.; Liozon F.
AUTHOR ADDRESSES
  (Mollaret P.; Turiaf J.; Bastin R.; Goulon M.; Lissac J.; Cophignon J.; 
Liozon F.)
CORRESPONDENCE ADDRESS
  P. Mollaret,
FULL RECORD ENTRY DATE
  1958-07-04
SOURCE
  Bulletins et mémoires de la Société médicale des hôpitaux de Paris (1958) 
74:24-25 (574-587). Date of Publication: 1958 Jul 4-11
VOLUME
  74
ISSUE
  24-25
FIRST PAGE
  574
LAST PAGE
  587
DATE OF PUBLICATION
  1958 Jul 4-11
ISSN
  0366-1334
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  asthma (therapy); ASTHMA/therapy; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  French
MEDLINE PMID
  13573157 (http://www.ncbi.nlm.nih.gov/pubmed/13573157)
PUI
  L80250434
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=03661334&id=doi:&atitle=Recovery+from+a+severe+asthmatic+state+following+tracheotomy%2C+endotracheal+respiration%2C+procaine+block+of+spinal+nerve+roots+%26+curarization.&stitle=Bull+Mem+Soc+Med+Hop+Paris&title=Bulletins+et+m%C3%A9moires+de+la+Soci%C3%A9t%C3%A9+m%C3%A9dicale+des+h%C3%B4pitaux+de+Paris&volume=74&issue=24-25&spage=574&epage=587&aulast=Mollaret&aufirst=P.&auinit=P.&aufull=Mollaret+P.&coden=&isbn=&pages=574-587&date=1958&auinit1=P&auinitm=
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1132
TITLE
  Emergency features of head injury
AUTHOR NAMES
  Reed H.L.
AUTHOR ADDRESSES
  (Reed H.L.)
FULL RECORD ENTRY DATE
  1957-12-01
SOURCE
  Journal of the International College of Surgeons (1957) 28:6 (749-755). Date 
of Publication: 1957
VOLUME
  28
ISSUE
  6
FIRST PAGE
  749
LAST PAGE
  755
DATE OF PUBLICATION
  1957
ISSN
  0096-557X
ABSTRACT
  The unconscious patient needs immediate attention for recognition and prompt 
treatment of tracheal obstruction, preferably with tracheotomy if this 
unconsciousness is expected to be prolonged. The unconscious patient equally 
needs immediate evaluation of the likelihood of injury to the neck, with or 
without involvement of the spinal cord, and proper diagnostic measures and 
immediate immobilization with traction if this is present. The extradural 
haematoma is an early and rapidly killing lesion that requires critical 
serial observation of the slightly or seriously injured person, and prompt 
diagnosis and surgical treatment are necessary to effect recovery, in 
contrast to the uniformly fatal outcome when treatment is delayed. Patients 
with compound fractures of the vault, although they merit early attention, 
are less urgently needed in the operating room and are better served by 
early general supportive measures and an opportunity to react to trauma. 
Chronic subdural haematoma is an elusive lesion, often occurring in 
alcoholic persons, with obscure symptoms requiring a high index of 
suspicion. When it is diagnosed early, definitive surgical treatment is 
indicated and usually brings gratifying results.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency; head injury; 
EMTREE MEDICAL INDEX TERMS
  alcoholism; child; diagnosis; epidural hematoma; fatality; immobilization; infant; injury; neck; open fracture; operating room; patient; spinal cord; subdural hematoma; surgery; trachea obstruction; tracheotomy; traction therapy; unconsciousness; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007519240
PUI
  L280905808
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0096557X&id=doi:&atitle=Emergency+features+of+head+injury&stitle=J.+Int.+Coll.+Surg.&title=Journal+of+the+International+College+of+Surgeons&volume=28&issue=6&spage=749&epage=755&aulast=Reed&aufirst=H.L.&auinit=H.L.&aufull=Reed+H.L.&coden=&isbn=&pages=749-755&date=1957&auinit1=H&auinitm=L
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1133
TITLE
  Safeguarding of the airway in cases of spinal poliomyelitis with respiratory 
insufficiency
ORIGINAL (NON-ENGLISH) TITLE
  Cuidados de las vias aereas en enfermos que han tenido poliomielitis espinal 
con insuficiencia respiratoria
AUTHOR NAMES
  Barani J.C.; Roncagliolo A.; Vera G.; Gomez L.; Nuñez C.; Ferreira E.; Perez Lagrave E.; Berterretche J.; Somma R.
AUTHOR ADDRESSES
  (Barani J.C.; Roncagliolo A.; Vera G.; Gomez L.; Nuñez C.; Ferreira E.; 
Perez Lagrave E.; Berterretche J.; Somma R.) Inst. de Epidemiol. y Enferm. 
Infect. 'Dr. J. Scoseria', Min. de Salud. Públ., Montevideo, Uruguay.
CORRESPONDENCE ADDRESS
  J.C. Barani, Inst. de Epidemiol. y Enferm. Infect. 'Dr. J. Scoseria', Min. 
de Salud. Públ., Montevideo, Uruguay.
FULL RECORD ENTRY DATE
  1957-12-01
SOURCE
  Archivos de Pediatria del Uruguay (1957) 28:5 (309-311). Date of 
Publication: 1957
VOLUME
  28
ISSUE
  5
FIRST PAGE
  309
LAST PAGE
  311
DATE OF PUBLICATION
  1957
ISSN
  0004-0584
ABSTRACT
  A report on 17 cases with affection of the respiratory muscles. Therapeutic 
measures used were Trendelenburg position, manual compression of the 
abdomen, positive pressure in a tank respirator and tracheotomy.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  airway; poliomyelitis; respiratory failure; 
EMTREE MEDICAL INDEX TERMS
  abdomen; book; breathing muscle; compression; rehabilitation; tracheotomy; ventilator; 
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007394358
PUI
  L280782654
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00040584&id=doi:&atitle=Safeguarding+of+the+airway+in+cases+of+spinal+poliomyelitis+with+respiratory+insufficiency&stitle=Arch.+Pediat.+Urug.&title=Archivos+de+Pediatria+del+Uruguay&volume=28&issue=5&spage=309&epage=311&aulast=Barani&aufirst=J.C.&auinit=J.C.&aufull=Barani+J.C.&coden=&isbn=&pages=309-311&date=1957&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1134
TITLE
  Respiratory care of patients who have suffered from spinal poliomyelitis 
with respiratory insufficiency
ORIGINAL (NON-ENGLISH) TITLE
  Cuidados de las vías aéreas en enfermos que han tenido poliomielitis espinal 
con insuficiencia respiratoria
AUTHOR NAMES
  Barani J.C.; Roncagliolo A.; Vera G.; Gómez L.; Nuñez C.; Ferreira E.; Pérez Lagrave A.; Berteche J.; Somma R.
AUTHOR ADDRESSES
  (Barani J.C.; Roncagliolo A.; Vera G.; Gómez L.; Nuñez C.; Ferreira E.; 
Pérez Lagrave A.; Berteche J.; Somma R.) Inst. de Epidemiol. y Enferm. 
Infectocontag. 'Dr. José Scosería', Montevideo, Uruguay.
CORRESPONDENCE ADDRESS
  J.C. Barani, Inst. de Epidemiol. y Enferm. Infectocontag. 'Dr. José 
Scosería', Montevideo, Uruguay.
FULL RECORD ENTRY DATE
  1957-12-01
SOURCE
  Otolaringologica (1957) 4:4 (529-530). Date of Publication: 1957
VOLUME
  4
ISSUE
  4
FIRST PAGE
  529
LAST PAGE
  530
DATE OF PUBLICATION
  1957
ABSTRACT
  Patients who have suffered from spinal poliomyelitis have a functional 
insufficiency of the diaphragm and of the intercostal muscles. They are very 
susceptible to acute diseases of the respiratory apparatus and cannot get 
rid of their sputum. In such cases, the Trendelenburg position, manual 
compression of the abdomen, iron lung and tracheotomy are indicated.
EMTREE DRUG INDEX TERMS
  iron; 
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  patient; poliomyelitis; respiratory care; respiratory failure; 
EMTREE MEDICAL INDEX TERMS
  abdomen; acute disease; book; compression; diaphragm; intercostal muscle; lung; pneumothorax; respiratory system; sputum; tracheotomy; 
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007575570
PUI
  L280955375
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Respiratory+care+of+patients+who+have+suffered+from+spinal+poliomyelitis+with+respiratory+insufficiency&stitle=Otolaringologica&title=Otolaringologica&volume=4&issue=4&spage=529&epage=530&aulast=Barani&aufirst=J.C.&auinit=J.C.&aufull=Barani+J.C.&coden=&isbn=&pages=529-530&date=1957&auinit1=J&auinitm=C
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1135
TITLE
  Acute medical care in poliomyelitis (Systemic treatment of the acute stage)
AUTHOR NAMES
  Russell W.R.
AUTHOR ADDRESSES
  (Russell W.R.) Dept. of Neurol., Radcliffe Infirm., Oxford.
CORRESPONDENCE ADDRESS
  W.R. Russell, Dept. of Neurol., Radcliffe Infirm., Oxford.
FULL RECORD ENTRY DATE
  1954-12-01
SOURCE
  Third Intern. Poliomyelitis Conf. (1954) (52). Date of Publication: 1954
FIRST PAGE
  52
DATE OF PUBLICATION
  1954
ABSTRACT
  The effect of treatment in the acute stage is difficult to assess and the 
fate of the spinal nerve cells is often decided before medical care is 
established. Paralysis is caused by destruction by the virus of spinal cord 
cells, and changes in muscle are not important. The virus-cell struggle is 
decided within a few days. Experimental attempts to influence this critical 
stage should be tested carefully on animals before using on patients. 
Complete physical rest after the onset of the major illness reduces the 
amount of paralysis and suitable sedation is helpful when this can be used 
safely. In bulbar cases, however, full sedation may precipitate the need for 
assisted respiration. In 80% of paralytic cases there is no serious danger 
to life, but in the remainder a very high degree of medical and nursing 
supervision may be required if life is to be saved. It is suggested that 
special respiration units should be established to which cases of special 
difficulty can be transferred from smaller hospitals receiving cases of 
poliomyelitis. Anaesthetists play a vital part in such units and for this 
reason a regional respiration unit should be present in the largest general 
hospital in the region. Cases requiring special supervision must be 
transferred under continual care of an anaesthetist using if necessary the 
apparatus required for controlled respiration. Cases with pharyngeal 
paralysis often preserve sufficient power of the muscles of respiration 
provided that the lungs can be kept healthy and atelectasis avoided. The 
supine position should be avoided even in the ambulance, as the inhalation 
of vomit must be avoided at all costs, for it often leads to irrecoverable 
changes in the lungs which cause death within a few hours. Frequent changes 
of bodily posture are essential if the lungs are to be kept healthy and the 
principles of postural drainage must be fully understood and applied. When 
failing respiration is due to spinal paralysis treatment in a tank-type of 
respirator should not be delayed, but when there is also pharyngeal 
paralysis, the method advocated by Ibsen and Lassen of positive pressure 
respiration through a tracheotomy tube is the method of choice. Care of the 
lungs takes priority over all else while life is in danger, but attention to 
the paralysed muscles must not be neglected. Continual relaxation of 
paralysed muscle is harmful as the resultant shortening makes the muscle 
tight and vulnerable to later stretching. Frequent passive movements are the 
most important need of paralysed muscles. Hot packs are sometimes useful but 
are not vitally important. Too many different methods of treatment are used 
and all should now be compared by measuring with graduated springs the 
strength of muscle groups during the period of recovery for a period of at 
least a year. Only by doing so can clarity emerge from the present confusing 
variety of methods of treatment in use.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  emergency care; poliomyelitis; systemic therapy; 
EMTREE MEDICAL INDEX TERMS
  ambulance; artificial ventilation; assisted ventilation; atelectasis; autopsy; body position; death; general aspects of disease; general hospital; hospital; inhalation; lung; medical care; muscle; nursing; paralysis; passive movement; patient; positive end expiratory pressure; postural drainage; rest; sedation; spinal cord; spinal cord nerve cell; spinal paralysis; stretching; supine position; tracheotomy; tube; ventilator; virus; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007464615
PUI
  L280851183
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=&id=doi:&atitle=Acute+medical+care+in+poliomyelitis+%28Systemic+treatment+of+the+acute+stage%29&stitle=Third+Intern.+Poliomyelitis+Conf.&title=&volume=&issue=&spage=52&epage=&aulast=Russell&aufirst=W.R.&auinit=W.R.&aufull=Russell+W.R.&coden=&isbn=&pages=52-&date=1954&auinit1=W&auinitm=R
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1136
TITLE
  Epidemiology of acute anterior poliomyelitis. III. Frequency of bulbar and 
spinal localizations in the above-mentioned hospital in 1951-1953
ORIGINAL (NON-ENGLISH) TITLE
  Studi sull'epidemiologia della poliomielite anteriore acuta. (III. Frequenza 
delle localizzazioni bulbari e spinali nella casistica dell'Ospedale 
Malattie Irfettive di Torino nel triennio 1951-1953)
AUTHOR NAMES
  Di Nola F.; Angela G.C.
AUTHOR ADDRESSES
  (Di Nola F.; Angela G.C.) Osped. Amedeo di Savoia per le Mal. Infett., 
Torino, Italy.
CORRESPONDENCE ADDRESS
  F. Di Nola, Osped. Amedeo di Savoia per le Mal. Infett., Torino, Italy.
FULL RECORD ENTRY DATE
  1954-12-01
SOURCE
  Minerva medica (Testo stampato) (1954) 2-45:71 (502-506). Date of 
Publication: 1954
VOLUME
  2-45
ISSUE
  71
FIRST PAGE
  502
LAST PAGE
  506
DATE OF PUBLICATION
  1954
ISSN
  0026-4806
ABSTRACT
  No shift towards the adult age-group was noted, nor was any increased 
virulence of the virus. Tracheotomy is indispensable in acute bulbar forms.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  epidemiology; hospital; poliomyelitis; 
EMTREE MEDICAL INDEX TERMS
  adult; groups by age; tracheotomy; virulence; virus; 
LANGUAGE OF ARTICLE
  Italian
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007892903
PUI
  L281200564
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00264806&id=doi:&atitle=Epidemiology+of+acute+anterior+poliomyelitis.+III.+Frequency+of+bulbar+and+spinal+localizations+in+the+above-mentioned+hospital+in+1951-1953&stitle=Minerva+Med.&title=Minerva+medica+%28Testo+stampato%29&volume=2-45&issue=71&spage=502&epage=506&aulast=Di+Nola&aufirst=F.&auinit=F.&aufull=Di+Nola+F.&coden=&isbn=&pages=502-506&date=1954&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1137
TITLE
  Care of the patient with multiple injuries
AUTHOR NAMES
  Mathewson Jr. C.
AUTHOR ADDRESSES
  (Mathewson Jr. C.) Stanford Univ. Hosps., San Francisco, CA, United States.
CORRESPONDENCE ADDRESS
  C. Mathewson Jr., Stanford Univ. Hosps., San Francisco, CA, United States.
FULL RECORD ENTRY DATE
  1954-12-01
SOURCE
  Surgical Clinics of North America (1954) (1455-1462). Date of Publication: 
1954
FIRST PAGE
  1455
LAST PAGE
  1462
DATE OF PUBLICATION
  1954
ISSN
  0039-6109
ABSTRACT
  Proper initial aid and transportation may obviate the production of further 
complications such as converting an unparalysed victim with a spinal injury 
to a permanent or complete paraplegic. Transportation with proper splints of 
fractures is elementary but should be continually emphasized. The extent of 
the initial injuries should be established by the initial physician and a 
base line recorded for progressive changes in signs and symptoms often are 
the key to correct diagnosis. Particularly is this true in intra-abdominal 
and head injuries. If there is question of asphyxia, a tracheotomy should be 
utilized early. Haemorrhage and shock, of course, should be corrected. It is 
pointed out that needless trauma from multiple laboratory procedures should 
be prevented if the clinical signs and symptoms are sufficient for 
diagnosis. When combined thoraco-abdominal injuries are encountered, the 
thoracic portion of the procedure usually is undertaken first in an attempt 
to restore normal cardiovascular physiology. In crush injuries of the chest, 
skeletal traction is a valuable and effective method of stabilizing the 
chest wall. Tracheotomy, of course, is mandatory. Penetrating wounds of the 
abdomen should, of course, be explored as soon as the general condition of 
the patient permits. Blunt injuries of the abdomen present a different but 
nonetheless serious problem. Ruptured spleen or bladder, lacerations of the 
liver and bowel, mesenteric haemorrhage and injuries to the pancreas all 
present difficult diagnostic problems. The presence of blood in the urine 
indicates injury to some level of the urinary tract. In head injuries, the 
importance of a recorded early and complete neurological examination should 
be recognized. Changes in the state of consciousness and in the neurological 
findings may be the only clues to the extent and progress of a brain injury. 
Initial management of specific types of injuries influenced by surgical 
judgment and proper timing of procedures may be life-saving.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  multiple trauma; patient; 
EMTREE MEDICAL INDEX TERMS
  abdomen; abdominal injury; asphyxia; bladder; bleeding; blood; blunt trauma; brain; brain injury; cardiovascular function; consciousness; crush trauma; decision making; diagnosis; fracture; general condition; head injury; injury; intestine; laboratory test; laceration; liver; neurologic examination; pancreas; paraplegia; penetrating trauma; physical disease by body function; physician; skeleton traction; spine injury; spleen; splint; thorax; thorax wall; tracheotomy; traffic and transport; urinary tract; urine; victim; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007386892
PUI
  L280775188
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00396109&id=doi:&atitle=Care+of+the+patient+with+multiple+injuries&stitle=Surg.+Clin.+N.+Amer.&title=Surgical+Clinics+of+North+America&volume=&issue=&spage=1455&epage=1462&aulast=Mathewson+Jr.&aufirst=C.&auinit=C.&aufull=Mathewson+Jr.+C.&coden=&isbn=&pages=1455-1462&date=1954&auinit1=C&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1138
TITLE
  Treatment of respiratory (spinal; bulbar and bulbospinal) types of 
poliomyelitis and radiculoneuritis (14 cases)
ORIGINAL (NON-ENGLISH) TITLE
  Tratamiento de las formas respiratorias (espinales, bulbares y 
bulboespinales) de la poliomielitis y de las radiculoneuritis. Presentación 
de 14 casos clinicos
AUTHOR NAMES
  López Clares F.
AUTHOR ADDRESSES
  (López Clares F.)
FULL RECORD ENTRY DATE
  1954-12-01
SOURCE
  Gaceta Medica de Mexico (1954) 84:5 (325-360). Date of Publication: 1954
VOLUME
  84
ISSUE
  5
FIRST PAGE
  325
LAST PAGE
  360
DATE OF PUBLICATION
  1954
ISSN
  0016-3813
ABSTRACT
  Tracheotomy was performed (with success) in 9 of the 14 cases. Clinically, 3 
cases were of bulbar type, 2 of bulbospinal radiculoneuritis, 4 of 
quadriplegia with muscular involvement, 3 of bulbospinal-type quadriplegias 
and 2 of diffuse (facial and bulbopontine) involvement with respiratory 
disturbances. The classical considerations on the treatment of these forms 
of poliomyelitis are reviewed.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  neuritis; poliomyelitis; 
EMTREE MEDICAL INDEX TERMS
  quadriplegia; respiratory failure; tracheotomy; 
LANGUAGE OF ARTICLE
  Spanish
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007218289
PUI
  L280610442
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00163813&id=doi:&atitle=Treatment+of+respiratory+%28spinal%3B+bulbar+and+bulbospinal%29+types+of+poliomyelitis+and+radiculoneuritis+%2814+cases%29&stitle=Gac.+Med.+Mex.&title=Gaceta+Medica+de+Mexico&volume=84&issue=5&spage=325&epage=360&aulast=L%C3%B3pez+Clares&aufirst=F.&auinit=F.&aufull=L%C3%B3pez+Clares+F.&coden=&isbn=&pages=325-360&date=1954&auinit1=F&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1139
TITLE
  A study of spinal fluid pressures in operations requiring removal of both 
internal jugular veins
AUTHOR NAMES
  Schweizer O.; Leak G.H.
AUTHOR ADDRESSES
  (Schweizer O.; Leak G.H.)
FULL RECORD ENTRY DATE
  1952-12-01
SOURCE
  Annals of surgery (1952) 136:6 (948-956). Date of Publication: 1952
VOLUME
  136
ISSUE
  6
FIRST PAGE
  948
LAST PAGE
  956
DATE OF PUBLICATION
  1952
ISSN
  0003-4932
ABSTRACT
  Removal of both internal jugular veins, either at one operation or in 2 
stages, did not result in a consistent rise in spinal fluid pressure. 
Clinical experience showed that removal of both jugular veins could be 
performed with minimal risk. An occasional patient did experience signs and 
symptoms of increased intracranial pressure, but these were transient and 
subsided spontaneously in the majority of cases. Tracheostomy is done 
routinely when the 2nd jugular vein is removed, and the 'head up' position 
is helpful.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cerebrospinal fluid; internal jugular vein; 
EMTREE MEDICAL INDEX TERMS
  anesthesia; intracranial hypertension; jugular vein; ligation; patient; physical disease by body function; risk; tracheostomy; vein; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007354392
PUI
  L280742688
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00034932&id=doi:&atitle=A+study+of+spinal+fluid+pressures+in+operations+requiring+removal+of+both+internal+jugular+veins&stitle=ANN.+SURG.&title=Annals+of+surgery&volume=136&issue=6&spage=948&epage=956&aulast=Schweizer&aufirst=O.&auinit=O.&aufull=Schweizer+O.&coden=&isbn=&pages=948-956&date=1952&auinit1=O&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1140
TITLE
  Tracheotomy in spinal respiratory paralysis.
AUTHOR NAMES
  Ohler R.L.; Provost P.E.
AUTHOR ADDRESSES
  (Ohler R.L.; Provost P.E.)
CORRESPONDENCE ADDRESS
  R.L. Ohler,
FULL RECORD ENTRY DATE
  1952-06-01
SOURCE
  The Journal of the Maine Medical Association (1952) 43:6 (169-174). Date of 
Publication: Jun 1952
VOLUME
  43
ISSUE
  6
FIRST PAGE
  169
LAST PAGE
  174
DATE OF PUBLICATION
  Jun 1952
ISSN
  0025-0694
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  poliomyelitis; 
EMTREE MEDICAL INDEX TERMS
  article; 
LANGUAGE OF ARTICLE
  English
MEDLINE PMID
  14938789 (http://www.ncbi.nlm.nih.gov/pubmed/14938789)
PUI
  L80996910
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00250694&id=doi:&atitle=Tracheotomy+in+spinal+respiratory+paralysis.&stitle=J+Maine+Med+Assoc&title=The+Journal+of+the+Maine+Medical+Association&volume=43&issue=6&spage=169&epage=174&aulast=Ohler&aufirst=R.L.&auinit=R.L.&aufull=Ohler+R.L.&coden=&isbn=&pages=169-174&date=1952&auinit1=R&auinitm=L
COPYRIGHT
  MEDLINE® is the source for the citation and abstract of this record.

RECORD 1141
TITLE
  The mechanism of suffocation in bulbo-spinal poliomyelitis and some primary 
experiences from surgical treatment
ORIGINAL (NON-ENGLISH) TITLE
  Om mekanismen vid kvävningsdöd i bulbo-spinal barnforlämning samt primara 
erfarenheter av den operativa behandlingen
AUTHOR NAMES
  Sjöberg A.
AUTHOR ADDRESSES
  (Sjöberg A.) Stockholms Epidemisjukhus, .
CORRESPONDENCE ADDRESS
  A. Sjöberg, Stockholms Epidemisjukhus, .
FULL RECORD ENTRY DATE
  1949-12-01
SOURCE
  Svenska Laekartidningen (1949) 46:51 (2745-2764). Date of Publication: 1949
VOLUME
  46
ISSUE
  51
FIRST PAGE
  2745
LAST PAGE
  2764
DATE OF PUBLICATION
  1949
ISSN
  0371-439X
ABSTRACT
  Eleven cases with respiratory difficulties were treated by tracheotomy and 
bronchoscopic drainage. Ten survived. Four different types of suffocation 
mechanism are distinguished depending on the involvement of the central 
nervous system. The indications for surgical procedures are discussed. (I) 
In patients with intercostal and diaphragmatic paralysis without bulbar 
involvement, bronchial secretions may necessitate bronchoscopic drainage 
with or without preceding tracheotomy. (II) In bulbar cases with pharyngeal 
paralysis, aspirated secretions often make the above-mentioned procedures 
inevitable. (III) In bulbar cases with pharyngeal paralysis and laryngeal 
abductor paralysis tracheotomy is always necessary. Paralysed, paramedially 
situated vocal cords, if tracheotomy is not performed, cause the respirator 
to lead to suffocation. (IV) In 6 out of the II cases there was a 
simultaneous bulbar and spinal involvement. When C1 and C2 are affected and 
there is at the same time a pharyngeal paralysis, the antagonists force the 
larynx upwards and backwards. The dislocation of the laryngeal entrance 
contributes to suffocation. When the patient is recumbent, the acute angle 
formed by the lower part of the mouth and the anterior contour of the neck 
is clearly observable (normally this is a right or obtuse angle). 
Tracheotomy must be immediately performed (often with the patient in the 
respirator). In many such cases the author found no mucus in the bronchi. It 
is therefore evident that the dislocation and not the secretions are in such 
cases responsible for death.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  asphyxia; poliomyelitis; surgery; 
EMTREE MEDICAL INDEX TERMS
  bodily secretions; bronchus; bronchus secretion; central nervous system; death; diaphragm paralysis; larynx; mucus; neck; paralysis; patient; surgical technique; tracheotomy; ventilator; vocal cord; 
LANGUAGE OF ARTICLE
  German
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007132619
PUI
  L280524772
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=0371439X&id=doi:&atitle=The+mechanism+of+suffocation+in+bulbo-spinal+poliomyelitis+and+some+primary+experiences+from+surgical+treatment&stitle=Svenska+Lakartidningen&title=Svenska+Laekartidningen&volume=46&issue=51&spage=2745&epage=2764&aulast=Sj%C3%B6berg&aufirst=A.&auinit=A.&aufull=Sj%C3%B6berg+A.&coden=&isbn=&pages=2745-2764&date=1949&auinit1=A&auinitm=
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.

RECORD 1142
TITLE
  Bulbar poliomyelitis. Its mechanism and treatment
AUTHOR NAMES
  Baker A.B.
AUTHOR ADDRESSES
  (Baker A.B.) Univ. of Minnoseta Medical School, Minncapolis.
CORRESPONDENCE ADDRESS
  A.B. Baker, Univ. of Minnoseta Medical School, Minncapolis.
FULL RECORD ENTRY DATE
  1949-12-01
SOURCE
  American Journal of Medicine (1949) 6:5 (614-619). Date of Publication: 1949
VOLUME
  6
ISSUE
  5
FIRST PAGE
  614
LAST PAGE
  619
DATE OF PUBLICATION
  1949
ISSN
  0002-9343
ABSTRACT
  Observation of 183 cases within a few months. Involvement of cranial nerve 
nuclei often led to difficulty in swallowing and obstruction of the airway. 
Suction, postural drainage and sometimes tracheotomy are advised. Lesions of 
the autonomic centres in the medulla are sometimes due to hypoxia. Treatment 
consists in oxygen therapy. Combined involvement of the bulb and the upper 
spinal cord makes respiratory treatment necessary.
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  poliomyelitis; 
EMTREE MEDICAL INDEX TERMS
  airway; cranial nerve; hypoxia; obstruction; oxygen therapy; postural drainage; spinal cord; suction; swallowing; tracheotomy; 
LANGUAGE OF ARTICLE
  English
LANGUAGE OF SUMMARY
  English
EMBASE ACCESSION NUMBER
  2007131055
PUI
  L280523208
DOI
  10.1016/0002-9343(49)90134-5
FULL TEXT LINK
  http://dx.doi.org/10.1016/0002-9343(49)90134-5
OPEN URL LINK
  http://mgetit.lib.umich.edu/sfx_locater?sid=EMBASE&issn=00029343&id=doi:10.1016%2F0002-9343%2849%2990134-5&atitle=Bulbar+poliomyelitis.+Its+mechanism+and+treatment&stitle=Am.+J.+Med.&title=American+Journal+of+Medicine&volume=6&issue=5&spage=614&epage=619&aulast=Baker&aufirst=A.B.&auinit=A.B.&aufull=Baker+A.B.&coden=&isbn=&pages=614-619&date=1949&auinit1=A&auinitm=B
COPYRIGHT
  Copyright 2007 Elsevier B.V., All rights reserved.