30 Records downloaded  - Fri Feb 23 19:53:52 UTC 2018


RECORD 1
TITLE
  Two cases of late-onset secondary adrenal insufficiency after 
discontinuation of nivolumab
AUTHOR NAMES
  Otsubo K.
  Nakatomi K.
  Furukawa R.
  Ashida K.
  Yoneshima Y.
  Nakanishi Y.
  Okamoto I.
AUTHOR ADDRESSES
  (Otsubo K.; Nakatomi K.; Furukawa R.; Yoneshima Y.; Nakanishi Y.; Okamoto 
I., okamotoi@kokyu.med.kyushu-u.ac.jp) Research Institute for Diseases of 
the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 
Japan.
(Ashida K.) Department of Medicine and Bioregulatory Science, Graduate 
School of Medical Sciences, Kyushu University, Fukuoka, Japan.
CORRESPONDENCE ADDRESS
  I. Okamoto, Research Institute for Diseases of the Chest, Graduate School of 
Medical Sciences, Kyushu University, Fukuoka, Japan. Email: 
okamotoi@kokyu.med.kyushu-u.ac.jp
SOURCE
  Annals of Oncology (2017) 28:12 (3106-3107). Date of Publication: 1 Dec 2017
ISSN
  1569-8041 (electronic)
  0923-7534
BOOK PUBLISHER
  Oxford University Press, jnl.info@oup.co.uk
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  adrenal insufficiency
EMTREE MEDICAL INDEX TERMS
  case report
  clinical article
  drug therapy
  drug withdrawal
  human
  letter
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20180120335
PUI
  L620758690
DOI
  10.1093/annonc/mdx497
FULL TEXT LINK
  http://dx.doi.org/10.1093/annonc/mdx497
COPYRIGHT
  Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 2
TITLE
  Pembrolizumab is effective for drug-resistant gestational trophoblastic 
neoplasia
AUTHOR NAMES
  Ghorani E.
  Kaur B.
  Fisher R.A.
  Short D.
  Joneborg U.
  Carlson J.W.
  Akarca A.
  Marafioti T.
  Quezada S.A.
  Sarwar N.
  Seckl M.J.
AUTHOR ADDRESSES
  (Ghorani E.; Fisher R.A.; Short D.; Sarwar N.; Seckl M.J., 
m.seckl@imperial.ac.uk) Department of Medical Oncology, Charing Cross 
Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial 
College London, London, United Kingdom.
(Kaur B.) Department of Histopathology, Charing Cross Gestational 
Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College 
London, London, United Kingdom.
(Ghorani E.; Quezada S.A.) Cancer Immunology Unit, University College London 
Cancer Institute, London, United Kingdom.
(Joneborg U.) Department of Women's and Children's Health, Karolinska 
Institutet, Karolinska University Hospital, Stockholm, Sweden.
(Carlson J.W.) Department of Oncology-Pathology, Karolinska Institutet, 
Karolinska University Hospital, Stockholm, Sweden.
(Akarca A.; Marafioti T.) Department of Cellular Pathology, University 
College London Hospital, London, United Kingdom.
SOURCE
  The Lancet (2017) 390:10110 (2343-2345). Date of Publication: 25 Nov 2017
ISSN
  1474-547X (electronic)
  0140-6736
BOOK PUBLISHER
  Lancet Publishing Group, cususerv@lancet.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  pembrolizumab (adverse drug reaction, drug therapy, drug toxicity)
EMTREE DRUG INDEX TERMS
  CD4 antigen (endogenous compound)
  CD56 antigen (endogenous compound)
  chorionic gonadotropin (endogenous compound)
  HLA G antigen (endogenous compound)
  programmed death 1 ligand 1 (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug efficacy
  trophoblastic tumor (drug therapy, drug resistance, drug therapy, surgery)
EMTREE MEDICAL INDEX TERMS
  adjuvant chemotherapy
  adult
  antigen expression
  cancer immunotherapy
  cancer recurrence
  cancer regression
  case report
  clinical article
  drug tolerability
  female
  helper cell
  human
  human tissue
  hysterectomy
  immunohistochemistry
  letter
  multiple cycle treatment
  priority journal
  treatment response
  tumor associated leukocyte
  unspecified side effect (side effect)
  uterus biopsy
CAS REGISTRY NUMBERS
  chorionic gonadotropin (9002-61-3)
  pembrolizumab (1374853-91-4)
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Cancer (16)
  Immunology, Serology and Transplantation (26)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  General Pathology and Pathological Anatomy (5)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170840145
PUI
  L619454330
DOI
  10.1016/S0140-6736(17)32894-5
FULL TEXT LINK
  http://dx.doi.org/10.1016/S0140-6736(17)32894-5
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 3
TITLE
  Case of metastatic uveal melanoma in which an antitumor effect appeared 
after ipilimumab discontinuation due to autoimmune hypophysitis
AUTHOR NAMES
  Ohnuma T.
  Matsuzawa T.
  Kinoshita M.
  Sano S.
  Kawamura T.
  Shimada S.
  Inozume T.
AUTHOR ADDRESSES
  (Ohnuma T.; Matsuzawa T.; Kinoshita M.; Sano S.; Kawamura T.; Shimada S.; 
Inozume T., tinozume@yamanashi.ac.jp) Department of Dermatology, University 
of Yamanashi, Chuo, Japan.
CORRESPONDENCE ADDRESS
  T. Inozume, Department of Dermatology, University of Yamanashi, Chuo, Japan. 
Email: tinozume@yamanashi.ac.jp
SOURCE
  Journal of Dermatology (2017) 44:11 (1325-1326). Date of Publication: 1 Nov 
2017
ISSN
  1346-8138 (electronic)
  0385-2407
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (drug therapy)
EMTREE DRUG INDEX TERMS
  hydrocortisone (drug therapy, intravenous drug administration, oral drug 
administration)
  nivolumab (drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autoimmune hypophysitis (diagnosis)
  metastatic uvea melanoma (drug therapy, drug therapy, surgery)
EMTREE MEDICAL INDEX TERMS
  adrenal cortex insufficiency (complication, diagnosis, drug therapy)
  adult
  case report
  clinical article
  computer assisted tomography
  drug withdrawal
  eye surgery
  fatigue
  female
  fever
  gastroscopy
  human
  letter
  loss of appetite
  lung metastasis
  medical history
  middle aged
  muscle weakness
  nuclear magnetic resonance imaging
  peritoneum metastasis
CAS REGISTRY NUMBERS
  hydrocortisone (50-23-7)
  ipilimumab (477202-00-9)
  nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
  Ophthalmology (12)
  Dermatology and Venereology (13)
  Cancer (16)
  Immunology, Serology and Transplantation (26)
  Endocrinology (3)
  Drug Literature Index (37)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160910184
PUI
  L613684765
DOI
  10.1111/1346-8138.13692
FULL TEXT LINK
  http://dx.doi.org/10.1111/1346-8138.13692
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 4
TITLE
  Acute-onset type 1 diabetes mellitus caused by nivolumab in a patient with 
advanced pulmonary adenocarcinoma
AUTHOR NAMES
  Kumagai R.
  Muramatsu A.
  Nakajima R.
  Fujii M.
  Kaino K.
  Katakura Y.
  Okumura N.
  Ohara G.
  Kagohashi K.
  Satoh H.
  Yagyu H.
AUTHOR ADDRESSES
  (Kumagai R.; Muramatsu A.; Fujii M.; Kaino K.; Katakura Y.; Yagyu H., 
hiroakiyagyu@aol.com) Department of Endocrinology and Metabolism, Tsukuba 
University Hospital Mito Clinical Education and Training Center, Mito Kyodo 
General Hospital, Mito, Japan.
(Nakajima R.; Okumura N.) Department of General Medicine, Tsukuba University 
Hospital Mito Clinical Education and Training Center, Mito Kyodo General 
Hospital, Mito, Japan.
(Ohara G.; Kagohashi K.; Satoh H.) Department of Respiratory Medicine, 
Tsukuba University Hospital Mito Clinical Education and Training Center, 
Mito Kyodo General Hospital, Mito, Japan.
CORRESPONDENCE ADDRESS
  H. Yagyu, Department of Endocrinology and Metabolism, Tsukuba University 
Hospital Mito Clinical Education and Training Center, Mito Kyodo General 
Hospital, Mito, Japan. Email: hiroakiyagyu@aol.com
SOURCE
  Journal of Diabetes Investigation (2017) 8:6 (798-799). Date of Publication: 
1 Nov 2017
ISSN
  2040-1124 (electronic)
  2040-1116
BOOK PUBLISHER
  Blackwell Publishing, info@asia.blackpublishing.com.au
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  amylase (endogenous compound)
  C peptide (endogenous compound)
  glucose (endogenous compound)
  hemoglobin A1c (endogenous compound)
  HLA DQB1 antigen (endogenous compound)
  HLA DRB1 antigen (endogenous compound)
  triacylglycerol lipase (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  insulin dependent diabetes mellitus (side effect, diagnosis, side effect)
  lung adenocarcinoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  aged
  amylase blood level
  body weight loss
  cancer staging
  case report
  clinical article
  computer assisted tomography
  disease exacerbation (side effect)
  drug withdrawal
  fatigue (side effect)
  glucose blood level
  glucose tolerance test
  hormone blood level
  hormone urine level
  human
  letter
  male
  pneumonia (side effect)
  priority journal
  triacylglycerol lipase blood level
  urine level
CAS REGISTRY NUMBERS
  amylase (9000-90-2, 9000-92-4, 9001-19-8)
  C peptide (59112-80-0)
  glucose (50-99-7, 84778-64-3)
  hemoglobin A1c (62572-11-6)
  nivolumab (946414-94-4)
  triacylglycerol lipase (9001-62-1)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170769917
PUI
  L619070884
DOI
  10.1111/jdi.12627
FULL TEXT LINK
  http://dx.doi.org/10.1111/jdi.12627
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 5
TITLE
  Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with 
Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response
AUTHOR NAMES
  Marchand L.
  Paulus V.
  Fabien N.
  Pérol M.
  Thivolet C.
  Vouillarmet J.
  Saintigny P.
AUTHOR ADDRESSES
  (Marchand L., Lucien.marchand@chu-lyon.fr; Thivolet C.; Vouillarmet J.) 
Department of Endocrinology and Diabetes, Hospices Civils de Lyon, Lyon-Sud 
Hospital, Pierre-Bénite, France.
(Paulus V.; Pérol M.; Saintigny P.) Department of Medical Oncology, Léon 
Bérard Cancer Center, Lyon, France.
(Fabien N.) Department of Immunology, Hospices Civils de Lyon, Lyon-Sud 
Hospital, Pierre-Bénite, France.
() Department of Endocrinology and Diabetes, Hospices Civils de Lyon, 
Lyon-Sud Hospital, Pierre-Bénite, France.
CORRESPONDENCE ADDRESS
  L. Marchand, Department of Endocrinology and Diabetes, Hospices Civils de 
Lyon, Lyon-Sud Hospital, 165 chemin du Grand Revoyet, Pierre-Bénite, France. 
Email: Lucien.marchand@chu-lyon.fr
SOURCE
  Journal of Thoracic Oncology (2017) 12:11 (e182-e184). Date of Publication: 
1 Nov 2017
ISSN
  1556-1380 (electronic)
  1556-0864
BOOK PUBLISHER
  Elsevier Inc, agents@lww.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  cisplatin (drug combination, drug therapy)
  corticotropin (endogenous compound)
  cytokeratin 7 (endogenous compound)
  docetaxel (drug combination, drug therapy)
  glycosylated hemoglobin (endogenous compound)
  hydrocortisone
  insulin (drug therapy)
  pemetrexed (drug therapy)
  programmed death 1 receptor (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  diabetes mellitus (drug therapy, side effect, diagnosis, drug therapy, side 
effect)
  hypophysitis (side effect, side effect)
  non small cell lung cancer (drug therapy, drug therapy)
  pulmonary pleomorphic carcinoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  adrenal biopsy
  adrenal insufficiency
  adrenal tumor
  adult
  asthenia
  case report
  clinical article
  computer assisted tomography
  dysphagia
  human
  human tissue
  hyperglycemia
  hyponatremia
  hypotension
  image guided biopsy
  immunohistochemistry
  ketoacidosis
  letter
  maintenance therapy
  male
  middle aged
  multiple cycle treatment
  nausea
  nose feeding
  polydipsia
  polyuria
  priority journal
  smoking
CAS REGISTRY NUMBERS
  cisplatin (15663-27-1, 26035-31-4, 96081-74-2)
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  docetaxel (114977-28-5)
  glycosylated hemoglobin (9062-63-9)
  hydrocortisone (50-23-7)
  insulin (9004-10-8)
  nivolumab (946414-94-4)
  pemetrexed (137281-23-3, 150399-23-8)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170760092
PUI
  L619005390
DOI
  10.1016/j.jtho.2017.07.021
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.jtho.2017.07.021
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 6
TITLE
  Anti-PD-1 Antibody Therapy Induces Hashimoto's Disease with an Increase in 
Peripheral Blood Follicular Helper T Cells
AUTHOR NAMES
  Torimoto K.
  Okada Y.
  Nakayamada S.
  Kubo S.
  Tanaka Y.
AUTHOR ADDRESSES
  (Torimoto K.; Okada Y.; Nakayamada S.; Kubo S.; Tanaka Y., 
tanaka@med.uoeh-u.ac.jp) First Department of Internal Medicine, School of 
Medicine, University of Occupational and Environmental Health, Japan, 1-1 
Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan.
CORRESPONDENCE ADDRESS
  Y. Tanaka, First Department of Internal Medicine, School of Medicine, 
University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, 
Yahatanishi-ku, Kitakyushu, Japan. Email: tanaka@med.uoeh-u.ac.jp
SOURCE
  Thyroid (2017) 27:10 (1335-1336). Date of Publication: 1 Oct 2017
ISSN
  1557-9077 (electronic)
  1050-7256
BOOK PUBLISHER
  Mary Ann Liebert Inc., info@liebertpub.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
  programmed death 1 ligand 1 (endogenous compound)
EMTREE DRUG INDEX TERMS
  autoantibody (endogenous compound)
  levothyroxine (drug therapy)
  thyroglobulin antibody (endogenous compound)
  thyroid peroxidase antibody (endogenous compound)
  thyroid stimulating immunoglobulin (endogenous compound)
  thyrotropin (endogenous compound)
  thyrotropin receptor antibody (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  blood
  Hashimoto disease (side effect, diagnosis, side effect)
  Tfh cell
EMTREE MEDICAL INDEX TERMS
  adult
  cancer chemotherapy
  cancer recurrence
  case report
  clinical article
  drug withdrawal
  echography
  free thyroxine index
  human
  hypothyroidism (drug therapy)
  letter
  lung cancer (drug therapy)
  male
  middle aged
  priority journal
  Th1 cell
  Th17 cell
  thyroid function
CAS REGISTRY NUMBERS
  levothyroxine (51-48-9)
  nivolumab (946414-94-4)
  thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
  Otorhinolaryngology (11)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170696072
PUI
  L618558334
DOI
  10.1089/thy.2017.0062
FULL TEXT LINK
  http://dx.doi.org/10.1089/thy.2017.0062
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 7
TITLE
  Complete serologic response to pembrolizumab in a woman with chemoresistant 
metastatic choriocarcinoma
AUTHOR NAMES
  Huang M.
  Pinto A.
  Castillo R.P.
  Slomovitz B.M.
AUTHOR ADDRESSES
  (Huang M.; Pinto A.; Castillo R.P.; Slomovitz B.M.) University of Miami, 
Miami, United States.
SOURCE
  Journal of Clinical Oncology (2017) 35:27 (3172-3174). Date of Publication: 
20 Sep 2017
ISSN
  1527-7755 (electronic)
  0732-183X
BOOK PUBLISHER
  American Society of Clinical Oncology, jcoservice@asco.org
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  pembrolizumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  carcinoembryonic antigen (endogenous compound)
  chorionic gonadotropin (endogenous compound)
  chorionic gonadotropin beta subunit (endogenous compound)
  cisplatin (drug therapy)
  cyclophosphamide (drug combination, drug therapy)
  dactinomycin (drug combination, drug therapy)
  etoposide (drug combination, drug therapy)
  homeobox protein Nkx 2.1 (endogenous compound)
  methotrexate (drug combination, drug therapy)
  neuroendocrine specific protein (endogenous compound)
  progesterone receptor (endogenous compound)
  protein (endogenous compound)
  protein p63 (endogenous compound)
  SAL like protein 4 (endogenous compound)
  transcription factor GATA 3 (endogenous compound)
  unclassified drug
  vincristine (drug combination, drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer resistance
  choriocarcinoma (drug therapy, drug resistance, drug therapy)
  drug response
EMTREE MEDICAL INDEX TERMS
  abdominal mass
  abdominal pain
  adult
  biliary stent
  biliary tract disease
  brain damage (drug therapy)
  case report
  clinical article
  corticosteroid therapy
  down regulation
  dyspnea
  female
  human
  human tissue
  hypertransaminasemia (side effect)
  immunohistochemistry
  letter
  liver biopsy
  liver injury
  lung nodule
  mediastinum mass
  neuroimaging
  nuclear magnetic resonance imaging
  pancreas disease
  priority journal
CAS REGISTRY NUMBERS
  chorionic gonadotropin (9002-61-3)
  cisplatin (15663-27-1, 26035-31-4, 96081-74-2)
  cyclophosphamide (50-18-0)
  dactinomycin (1402-38-6, 1402-58-0, 50-76-0)
  etoposide (33419-42-0, 433304-61-1)
  methotrexate (15475-56-6, 59-05-2, 7413-34-5)
  pembrolizumab (1374853-91-4)
  protein (67254-75-5)
  transcription factor GATA 3 (137878-55-8)
  vincristine (57-22-7)
EMBASE CLASSIFICATIONS
  Obstetrics and Gynecology (10)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170670152
PUI
  L618313655
DOI
  10.1200/JCO.2017.74.4052
FULL TEXT LINK
  http://dx.doi.org/10.1200/JCO.2017.74.4052
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 8
TITLE
  Hypopituitarism and hypothyroidism following atrioventricular block during 
nivolumab treatment
AUTHOR NAMES
  Oda T.
  Sawada Y.
  Okada E.
  Yamaguchi T.
  Ohmori S.
  Haruyama S.
  Yoshioka M.
  Nakamura M.
AUTHOR ADDRESSES
  (Oda T.; Sawada Y., long-ago@med.uoeh-u.ac.jp; Okada E.; Yamaguchi T.; 
Ohmori S.; Haruyama S.; Yoshioka M.; Nakamura M.) Department of Dermatology, 
University of Occupational and Environmental Health, Kitakyushu, Japan.
CORRESPONDENCE ADDRESS
  Y. Sawada, Department of Dermatology, University of Occupational and 
Environmental Health, Kitakyushu, Japan. Email: long-ago@med.uoeh-u.ac.jp
SOURCE
  Journal of Dermatology (2017) 44:6 (e144-e145). Date of Publication: 1 Jun 
2017
ISSN
  1346-8138 (electronic)
  0385-2407
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy, intravenous drug 
administration, pharmacology)
EMTREE DRUG INDEX TERMS
  hydrocortisone (drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  atrioventricular block (side effect, diagnosis, side effect, therapy)
  hypopituitarism (side effect, diagnosis, side effect)
  hypothyroidism (side effect, diagnosis, side effect)
EMTREE MEDICAL INDEX TERMS
  adrenal insufficiency (drug therapy)
  aged
  case report
  computer assisted tomography
  fatigue
  forehead
  histopathology
  human
  laboratory test
  letter
  loss of appetite
  lung metastasis
  male
  melanoma (diagnosis, drug therapy)
  outcome assessment
  patient referral
  skin biopsy
  skin manifestation (diagnosis)
  very elderly
CAS REGISTRY NUMBERS
  hydrocortisone (50-23-7)
  nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Cardiovascular Diseases and Cardiovascular Surgery (18)
  Endocrinology (3)
  Clinical and Experimental Pharmacology (30)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170197741
PUI
  L614844204
DOI
  10.1111/1346-8138.13797
FULL TEXT LINK
  http://dx.doi.org/10.1111/1346-8138.13797
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 9
TITLE
  Immune checkpoint inhibitors-related orchitis
AUTHOR NAMES
  Brunet-Possenti F.
  Opsomer M.A.
  Gomez L.
  Ouzaid I.
  Descamps V.
AUTHOR ADDRESSES
  (Brunet-Possenti F., florence.brunet-possenti@aphp.fr; Descamps V.) 
Department of Dermatology, Bichat Claude Bernard Hospital, AP-HP, Paris, 
France.
(Opsomer M.A.) Department of Pharmacology, Bichat Claude Bernard Hospital, 
AP-HP, Paris, France.
(Gomez L.) Department of Nuclear Medicine, Bichat Claude Bernard Hospital, 
AP-HP, Paris, France.
(Ouzaid I.) Department of Urology, Bichat Claude Bernard Hospital, AP-HP, 
Paris, France.
CORRESPONDENCE ADDRESS
  F. Brunet-Possenti, Department of Dermatology, Bichat Claude Bernard 
Hospital, AP-HP, Paris, France. Email: florence.brunet-possenti@aphp.fr
SOURCE
  Annals of Oncology (2017) 28:4 (906-907) Article Number: mdw696. Date of 
Publication: 1 Apr 2017
ISSN
  1569-8041 (electronic)
  0923-7534
BOOK PUBLISHER
  Oxford University Press, jnl.info@oup.co.uk
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, drug combination, drug therapy)
  nivolumab (adverse drug reaction, drug combination, drug therapy)
EMTREE DRUG INDEX TERMS
  fluorodeoxyglucose
  luteinizing hormone (endogenous compound)
  testosterone (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  orchitis (side effect, diagnosis, side effect)
EMTREE MEDICAL INDEX TERMS
  adult
  blood examination
  bone lesion (diagnosis)
  bone metastasis (diagnosis)
  cancer combination chemotherapy
  cancer localization
  cancer staging
  case report
  clinical examination
  drug efficacy
  drug infusion
  drug tolerability
  human
  hypogonadism (diagnosis)
  immune response
  letter
  male
  melanoma (drug therapy)
  middle aged
  positron emission tomography
  priority journal
  scrotal swelling (diagnosis, side effect)
  testosterone blood level
  treatment response
CAS REGISTRY NUMBERS
  fluorodeoxyglucose (29702-43-0)
  ipilimumab (477202-00-9)
  luteinizing hormone (39341-83-8, 9002-67-9)
  nivolumab (946414-94-4)
  testosterone (58-22-0)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Nuclear Medicine (23)
  Urology and Nephrology (28)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170339657
PUI
  L616106162
DOI
  10.1093/annonc/mdw696
FULL TEXT LINK
  http://dx.doi.org/10.1093/annonc/mdw696
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 10
TITLE
  Case of type 1 diabetes associated with less-dose nivolumab therapy in a 
melanoma patient
AUTHOR NAMES
  Teramoto Y.
  Nakamura Y.
  Asami Y.
  Imamura T.
  Takahira S.
  Nemoto M.
  Sakai G.
  Shimada A.
  Noda M.
  Yamamoto A.
AUTHOR ADDRESSES
  (Teramoto Y., y_tera@saitama-med.ac.jp; Nakamura Y.; Asami Y.; Imamura T.; 
Yamamoto A.) Department of Skin Oncology/Dermatology, Saitama Medical 
University International Medical Center, Saitama, Japan.
(Takahira S.; Nemoto M.) Division of Traumatology and Emergency Acute 
Medicine, Saitama Medical University International Medical Center, Saitama, 
Japan.
(Sakai G.; Shimada A.; Noda M.) Department of Endocrinology and Diabetes, 
Saitama Medical University, Saitama, Japan.
CORRESPONDENCE ADDRESS
  Y. Teramoto, Department of Skin Oncology/Dermatology, Saitama Medical 
University International Medical Center, Saitama, Japan. Email: 
y_tera@saitama-med.ac.jp
SOURCE
  Journal of Dermatology (2017) 44:5 (605-606). Date of Publication: 1 May 
2017
ISSN
  1346-8138 (electronic)
  0385-2407
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  amylase (endogenous compound)
  bicarbonate (endogenous compound)
  C peptide (endogenous compound)
  dacarbazine (drug therapy)
  elastase (endogenous compound)
  elastase I (endogenous compound)
  glucose (endogenous compound)
  hemoglobin A1c (endogenous compound)
  insulin (drug therapy)
  ketone body (endogenous compound)
  unclassified drug
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer immunotherapy
  insulin dependent diabetes mellitus (drug therapy, side effect, diagnosis, 
drug therapy, side effect)
  melanoma (drug therapy, drug therapy)
  vulvar melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  adult
  amylase blood level
  cancer growth
  cancer patient
  case report
  diabetic ketoacidosis (complication, diagnosis)
  disease association
  drug withdrawal
  fatigue (complication)
  female
  glucose blood level
  glycemic control
  human
  insulin release
  insulin treatment
  letter
  middle aged
  pH
  polydipsia (complication)
  polyuria (complication)
CAS REGISTRY NUMBERS
  amylase (9000-90-2, 9000-92-4, 9001-19-8)
  bicarbonate (144-55-8, 71-52-3)
  C peptide (59112-80-0)
  dacarbazine (4342-03-4)
  elastase (9004-06-2)
  glucose (50-99-7, 84778-64-3)
  hemoglobin A1c (62572-11-6)
  insulin (9004-10-8)
  nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170302735
PUI
  L615706972
DOI
  10.1111/1346-8138.13486
FULL TEXT LINK
  http://dx.doi.org/10.1111/1346-8138.13486
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 11
TITLE
  Isolated adrenocorticotropic hormone deficiency associated with nivolumab 
therapy
AUTHOR NAMES
  Narahira A.
  Yanagi T.
  Cho K.Y.
  Nakamura A.
  Miyoshi H.
  Hata H.
  Imafuku K.
  Kitamura S.
  Shimizu H.
AUTHOR ADDRESSES
  (Narahira A.; Yanagi T., yanagi@med.hokudai.ac.jp; Hata H.; Imafuku K.; 
Kitamura S.; Shimizu H.) Department of Dermatology, Hokkaido University 
Graduate School of Medicine, Sapporo, Japan.
(Cho K.Y.; Nakamura A.; Miyoshi H.) Division of Rheumatology, Endocrinology 
and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, 
Japan.
CORRESPONDENCE ADDRESS
  T. Yanagi, Department of Dermatology, Hokkaido University Graduate School of 
Medicine, Sapporo, Japan. Email: yanagi@med.hokudai.ac.jp
SOURCE
  Journal of Dermatology (2017) 44:4 (e70). Date of Publication: 1 Apr 2017
ISSN
  1346-8138 (electronic)
  0385-2407
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  corticotropin (endogenous compound)
  corticotropin releasing factor (endogenous compound)
  follitropin (endogenous compound)
  growth hormone (endogenous compound)
  hydrocortisone (drug therapy)
  luteinizing hormone (endogenous compound)
  prolactin (endogenous compound)
  sodium (endogenous compound)
  thyrotropin (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  corticotropin deficiency (drug therapy, side effect, drug therapy, side 
effect)
  isolated ACTH deficiency (drug therapy, side effect, drug therapy, side 
effect)
EMTREE MEDICAL INDEX TERMS
  aged
  anterior pituitary stimulation test
  bradykinesia
  case report
  corticotropin blood level
  disease association
  endocrine function test
  fatigue
  female
  human
  hydrocortisone blood level
  hyponatremia
  letter
  loss of appetite
  metastatic melanoma (drug therapy)
  multiple cycle treatment
  sodium blood level
CAS REGISTRY NUMBERS
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  corticotropin releasing factor (9015-71-8, 178359-01-8, 79804-71-0, 
86297-72-5, 86784-80-7)
  follitropin (9002-68-0)
  growth hormone (36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6)
  hydrocortisone (50-23-7)
  luteinizing hormone (39341-83-8, 9002-67-9)
  nivolumab (946414-94-4)
  prolactin (12585-34-1, 50647-00-2, 9002-62-4)
  sodium (7440-23-5)
  thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170258312
PUI
  L615243911
DOI
  10.1111/1346-8138.13571
FULL TEXT LINK
  http://dx.doi.org/10.1111/1346-8138.13571
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 12
TITLE
  Fulminant type 1 diabetes caused by dual immune checkpoint blockade in 
metastatic renal cell carcinoma
AUTHOR NAMES
  Teló G.H.
  Carvalhal G.F.
  Cauduro C.G.S.
  Webber V.S.
  Barrios C.H.
  Fay A.P.
AUTHOR ADDRESSES
  (Teló G.H.) Endocrinology Department, Federal University of Rio Grande do 
Sul (UFRGS), Porto Alegre, Brazil.
(Carvalhal G.F.; Cauduro C.G.S.; Barrios C.H.; Fay A.P., andre.fay@pucrs.br) 
School of Medicine, PUCRS, Porto Alegre, Brazil.
(Webber V.S.; Barrios C.H.; Fay A.P., andre.fay@pucrs.br) Clinical Research 
Center, PUCRS, Porto Alegre, Brazil.
(Barrios C.H.; Fay A.P., andre.fay@pucrs.br) Medical Oncology, Hospital do 
CâncerMãe de Deus, Porto Alegre, Brazil.
(Barrios C.H.; Fay A.P., andre.fay@pucrs.br) Latin American Cooperative 
Oncology Group (LACOG), Porto Alegre, Brazil.
CORRESPONDENCE ADDRESS
  A.P. Fay, School of Medicine, PUCRS, Porto Alegre, Brazil. Email: 
andre.fay@pucrs.br
SOURCE
  Annals of Oncology (2017) 28:1 (191-192). Date of Publication: 1 Jan 2017
ISSN
  1569-8041 (electronic)
  0923-7534
BOOK PUBLISHER
  Oxford University Press, jnl.info@oup.co.uk
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, drug combination, drug therapy)
  nivolumab (adverse drug reaction, drug combination, drug therapy)
EMTREE DRUG INDEX TERMS
  triacylglycerol lipase (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fulminant insulin dependent diabetes mellitus (side effect, diagnosis, side 
effect)
  insulin dependent diabetes mellitus (side effect, diagnosis, side effect)
  kidney carcinoma (drug therapy, drug therapy)
  metastasis (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  adult
  case report
  computer assisted tomography
  confusion
  diabetic ketoacidosis
  drug response
  fatigue
  fever
  flu like syndrome
  glycemic control
  human
  hyperglycemia
  ketoacidosis
  letter
  male
  middle aged
  pancreatitis (diagnosis)
  pneumonia
  polydipsia
  polyuria
  triacylglycerol lipase blood level
CAS REGISTRY NUMBERS
  ipilimumab (477202-00-9)
  nivolumab (946414-94-4)
  triacylglycerol lipase (9001-62-1)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Urology and Nephrology (28)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170214180
PUI
  L614949602
DOI
  10.1093/annonc/mdw447
FULL TEXT LINK
  http://dx.doi.org/10.1093/annonc/mdw447
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 13
TITLE
  A case of fulminant type 1 diabetes mellitus, with a precipitous decrease in 
pancreatic volume, induced by nivolumab for malignant melanoma: Analysis of 
HLA and CTLA-4 polymorphisms
AUTHOR NAMES
  Ishikawa K.
  Shono-Saito T.
  Yamate T.
  Kai Y.
  Sakai T.
  Shimizu F.
  Yamada Y.
  Mori H.
  Noso S.
  Ikegami H.
  Kojima H.
  Tanaka H.
  Fujiwara S.
  Hatano Y.
AUTHOR ADDRESSES
  (Ishikawa K.; Shono-Saito T.; Yamate T.; Kai Y.; Sakai T.; Fujiwara S.; 
Hatano Y., hatano@oita-u.ac.jp) Department of Dermatology, Faculty of 
Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Japan.
(Shimizu F.) Department of Plastic Surgery, Faculty of Medicine, Oita 
University, 1-1 Idaigaoka, Hasama-machi, Yufu, Japan.
(Yamada Y.; Mori H.) Department of Radiology, Faculty of Medicine, Oita 
University, 1-1 Idaigaoka, Hasama-machi, Yufu, Japan.
(Noso S.; Ikegami H.) Department of Endocrinology Metabolism and Diabetes, 
Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-sayama, 
Osaka, Japan.
(Kojima H.; Tanaka H.) HLA Foundation Laboratory, Kyoto, Japan.
CORRESPONDENCE ADDRESS
  Y. Hatano, Department of Dermatology, Faculty of Medicine, Oita University, 
1-1 Idaigaoka, Hasama-machi, Yufu, Japan. Email: hatano@oita-u.ac.jp
SOURCE
  European Journal of Dermatology (2017) 27:2 (184-185). Date of Publication: 
2017
ISSN
  1952-4013 (electronic)
  1167-1122
BOOK PUBLISHER
  John Libbey Eurotext, 127, avenue de la Republique, Montrouge, France. 
contact@jle.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cytotoxic T lymphocyte antigen 4 (endogenous compound)
  HLA antigen (endogenous compound)
  nivolumab (drug therapy)
EMTREE DRUG INDEX TERMS
  B Raf kinase (endogenous compound)
  cysteinyldopa
  hemoglobin A1c (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  fulminant insulin dependent diabetes mellitus (diagnosis)
  insulin dependent diabetes mellitus (diagnosis)
  melanoma (drug therapy, diagnosis, drug therapy)
  organ size
  pancreatic volume
EMTREE MEDICAL INDEX TERMS
  adipose tissue
  adult
  blood sampling
  breslow thickness
  cancer chemotherapy
  case report
  computer assisted tomography
  cytotoxic T lymphocyte antigen 4 gene
  female
  gene
  genotype
  HLA antigen gene
  human
  hyperglycemia
  insulin treatment
  letter
  lymph node metastasis
  middle aged
  oncological parameters
  polydipsia
  single nucleotide polymorphism
CAS REGISTRY NUMBERS
  cysteinyldopa (19641-92-0)
  hemoglobin A1c (62572-11-6)
  nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Human Genetics (22)
  Drug Literature Index (37)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170284969
PUI
  L615491345
DOI
  10.1684/ejd.2016.2923
FULL TEXT LINK
  http://dx.doi.org/10.1684/ejd.2016.2923
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 14
TITLE
  Isolated adrenocorticotropic hormone deficiency possibly caused by nivolumab 
in a metastatic melanoma patient
AUTHOR NAMES
  Fujimura T.
  Kambayashi Y.
  Furudate S.
  Kakizaki A.
  Hidaka T.
  Haga T.
  Hashimoto A.
  Morimoto R.
  Aiba S.
AUTHOR ADDRESSES
  (Fujimura T., tfujimura1@mac.com; Kambayashi Y.; Furudate S.; Kakizaki A.; 
Hidaka T.; Haga T.; Hashimoto A.; Aiba S.) Department of Dermatology, Tohoku 
University Graduate School of Medicine, Sendai, Japan.
(Morimoto R.) Division of Nephrology, Endocrinology and Vascular Medicine, 
Department of Medicine, Tohoku University Hospital, Sendai, Japan.
CORRESPONDENCE ADDRESS
  T. Fujimura, Department of Dermatology, Tohoku University Graduate School of 
Medicine, Sendai, Japan. Email: tfujimura1@mac.com
SOURCE
  Journal of Dermatology (2017) 44:3 (e13-e14). Date of Publication: 1 Mar 
2017
ISSN
  1346-8138 (electronic)
  0385-2407
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  CD163 antigen (endogenous compound)
  corticotropin (endogenous compound)
  epithelial derived neutrophil activating factor 78 (endogenous compound)
  thyrotropin (endogenous compound)
  tumor necrosis factor (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  corticotropin deficiency (side effect, diagnosis, side effect)
  metastatic melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  acral lentiginous melanoma (surgery)
  aged
  brain metastasis (diagnosis, radiotherapy)
  case report
  cutaneous melanoma (surgery)
  CyberKnife
  human
  human tissue
  hypopituitarism
  letter
  male
  nuclear magnetic resonance imaging
  skin nodule
  thyrotropin blood level
DEVICE TRADE NAMES
  CyberKnife  , United StatesAccuray

DEVICE MANUFACTURERS
   (United States)Accuray
CAS REGISTRY NUMBERS
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  epithelial derived neutrophil activating factor 78 (136956-40-6)
  nivolumab (946414-94-4)
  thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Biophysics, Bioengineering and Medical Instrumentation (27)
  Urology and Nephrology (28)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160553134
PUI
  L611375839
DOI
  10.1111/1346-8138.13532
FULL TEXT LINK
  http://dx.doi.org/10.1111/1346-8138.13532
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 15
TITLE
  Hyponatremia can be a powerful predictor of the development of isolated ACTH 
deficiency associated with nivolumab treatment
AUTHOR NAMES
  Cho K.Y.
  Miyoshi H.
  Nakamura A.
  Kurita T.
  Atsumi T.
AUTHOR ADDRESSES
  (Cho K.Y., kyuyong-cho@med.hokudai.ac.jp; Miyoshi H.; Nakamura A.; Atsumi 
T.) Division of Rheumatology, Endocrinology and Nephrology, Hokkaido 
University Graduate School of Medicine, Sapporo, Japan.
(Kurita T.) Department of Internal Medicine, Japanese Red Cross Kitami 
Hospital, Kitami, Japan.
CORRESPONDENCE ADDRESS
  K.Y. Cho, Division of Rheumatology, Endocrinology and Nephrology, Hokkaido 
University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 
Hokkaido, Japan. Email: kyuyong-cho@med.hokudai.ac.jp
SOURCE
  Endocrine Journal (2017) 64:2 (235-236). Date of Publication: 2017
ISSN
  1348-4540 (electronic)
  0918-8959
BOOK PUBLISHER
  Japan Endocrine Society, endo-soc-japan@ml.infoweb.ne.jp
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  corticotropin (endogenous compound)
  hydrocortisone (drug therapy, endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  corticotropin deficiency (drug therapy, side effect, diagnosis, drug 
therapy, side effect)
  disease course
  hyponatremia (side effect, diagnosis, side effect)
  prediction
EMTREE MEDICAL INDEX TERMS
  adult
  aged
  case report
  corticotropin blood level
  drug safety
  endocrine function test
  fatigue (side effect)
  female
  hormone substitution
  human
  hydrocortisone blood level
  hydrocortisone release
  hypotension
  laboratory test
  letter
  loss of appetite (side effect)
  male
  melanoma (drug therapy)
  middle aged
  nausea (side effect)
  non small cell lung cancer (drug therapy)
  pain (side effect)
  treatment response
CAS REGISTRY NUMBERS
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  hydrocortisone (50-23-7)
  nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Clinical and Experimental Biochemistry (29)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170156969
PUI
  L614613118
DOI
  10.1507/endocrj.EJ16-0596
FULL TEXT LINK
  http://dx.doi.org/10.1507/endocrj.EJ16-0596
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 16
TITLE
  Hypothyroidism associated with nivolumab treatment of unresectable malignant 
melanoma
AUTHOR NAMES
  Imafuku K.
  Yoshino K.
  Yamaguchi K.
  Tsuboi S.
  Ohara K.
  Hata H.
AUTHOR ADDRESSES
  (Imafuku K., imafukukeisuke@gmail.com; Yoshino K.; Yamaguchi K.; Tsuboi S.; 
Ohara K.) Department of Dermatology, Tokyo Metropolitan Cancer and 
Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagoame, 
Bunkyo-ku, Tokyo, Tokyo, Japan.
(Hata H.) Department of Dermatology, Hokkaido University Graduate School of 
Medicine, Sapporo, Japan.
SOURCE
  Clinical and Experimental Dermatology (2017) 42:2 (217-218). Date of 
Publication: 1 Mar 2017
ISSN
  1365-2230 (electronic)
  0307-6938
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  thyroid hormone (drug therapy)
  thyrotropin (endogenous compound)
  thyroxine (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug induced disease (drug therapy, side effect, drug therapy, side effect)
  hypothyroidism (drug therapy, side effect, drug therapy, side effect)
  inoperable cancer (drug therapy, drug therapy)
  melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  aged
  cancer immunotherapy
  case report
  disease exacerbation
  drug withdrawal
  heart failure
  hormonal therapy
  human
  letter
  male
  multiple cycle treatment
  patient care
  priority journal
  thyrotropin blood level
  thyroxine blood level
CAS REGISTRY NUMBERS
  nivolumab (946414-94-4)
  thyrotropin (9002-71-5)
  thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170052142
MEDLINE PMID
  28052364 (http://www.ncbi.nlm.nih.gov/pubmed/28052364)
PUI
  L614107353
DOI
  10.1111/ced.13028
FULL TEXT LINK
  http://dx.doi.org/10.1111/ced.13028
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 17
TITLE
  Autoimmune diabetes superimposed on type 2 diabetes in a patient initiated 
on immunotherapy for lung cancer
AUTHOR NAMES
  Alhusseini M.
  Samantray J.
AUTHOR ADDRESSES
  (Alhusseini M., malhusse@med.wayne.edu; Samantray J.) Department of Internal 
Medicine, Division of Endocrinology, Detroit Medical Center, Wayne State 
University School of Medicine, University Health Center, 4201 St. Antoine, 
Suite 4H, Detroit, United States.
CORRESPONDENCE ADDRESS
  M. Alhusseini, Department of Internal Medicine, Division of Endocrinology, 
Detroit Medical Center, Wayne State University School of Medicine, 
University Health Center, 4201 St. Antoine, Suite 4H, Detroit, United 
States. Email: malhusse@med.wayne.edu
SOURCE
  Diabetes and Metabolism (2017) 43:1 (86-88). Date of Publication: 1 Feb 2017
ISSN
  1878-1780 (electronic)
  1262-3636
BOOK PUBLISHER
  Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex, 
France.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, clinical trial, drug therapy)
  pembrolizumab (adverse drug reaction, clinical trial, drug therapy)
EMTREE DRUG INDEX TERMS
  C peptide (endogenous compound)
  glimepiride (drug combination, drug therapy)
  glucose (endogenous compound)
  glutamate decarboxylase 65 (endogenous compound)
  hemoglobin A1c (endogenous compound)
  levothyroxine (drug therapy)
  metformin (drug combination, drug therapy)
  thyroid peroxidase antibody (endogenous compound)
  thyroid stimulating immunoglobulin (endogenous compound)
  thyrotropin (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  cancer immunotherapy
  latent autoimmune diabetes in adults (side effect, side effect)
  lung adenocarcinoma (drug therapy, drug therapy, therapy)
  non insulin dependent diabetes mellitus (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  aged
  anion gap
  asymptomatic disease
  case report
  diabetic ketoacidosis
  drug withdrawal
  follow up
  free thyroxine index
  glucose blood level
  human
  hyperthyroidism (drug therapy)
  hypothyroidism
  insulin treatment
  letter
  male
  thyroiditis
  tumor volume
  vomiting
CAS REGISTRY NUMBERS
  C peptide (59112-80-0)
  glimepiride (93479-97-1)
  glucose (50-99-7, 84778-64-3)
  hemoglobin A1c (62572-11-6)
  ipilimumab (477202-00-9)
  levothyroxine (51-48-9)
  metformin (1115-70-4, 657-24-9)
  pembrolizumab (1374853-91-4)
  thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
  Chest Diseases, Thoracic Surgery and Tuberculosis (15)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Internal Medicine (6)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160936975
MEDLINE PMID
  27291328 (http://www.ncbi.nlm.nih.gov/pubmed/27291328)
PUI
  L613819714
DOI
  10.1016/j.diabet.2016.05.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.diabet.2016.05.007
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 18
TITLE
  Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI 
findings
AUTHOR NAMES
  Singh D.
  Hsu C.C.-T.
  Kwan G.N.C.
  Bhuta S.
AUTHOR ADDRESSES
  (Singh D., dsingh1386@gmail.com) Department of Medical Imaging, School of 
Medicine, University of Queensland, Brisbane, Australia.
(Hsu C.C.-T.; Kwan G.N.C.; Bhuta S.) Department of Medical Imaging, Gold 
Coast University Hospital, Southport, Australia.
CORRESPONDENCE ADDRESS
  D. Singh, Department of Medical Imaging, School of Medicine, University of 
Queensland, Brisbane, Australia. Email: dsingh1386@gmail.com
SOURCE
  Neurology India (2017) 65:1 (165-166). Date of Publication: 1 Jan 2017
ISSN
  1998-4022 (electronic)
  0028-3886
BOOK PUBLISHER
  Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar 
(E), Mumbai, India.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  corticotropin (endogenous compound)
  dexamethasone (drug combination, drug dose, drug therapy)
  follitropin (endogenous compound)
  hydrocortisone (endogenous compound)
  luteinizing hormone (endogenous compound)
  prednisone (drug combination, drug dose, drug therapy)
  prolactin (endogenous compound)
  testosterone (endogenous compound)
  testosterone undecanoate (intramuscular drug administration)
  thyrotropin (endogenous compound)
  thyroxine (drug therapy, endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  colitis (drug therapy, side effect, diagnosis, drug therapy, side effect)
  hypophysitis (drug therapy, side effect, diagnosis, drug therapy, side 
effect)
  ileum disease (drug therapy, side effect, diagnosis, drug therapy, side 
effect)
  nuclear magnetic resonance imaging
EMTREE MEDICAL INDEX TERMS
  abdominal pain
  adult
  case report
  colon biopsy
  computer assisted tomography
  contrast enhancement
  diarrhea
  disease severity
  drug megadose
  drug withdrawal
  granulomatous inflammation (diagnosis)
  headache
  histopathology
  human
  human cell
  human tissue
  hypothyroidism (diagnosis, drug therapy)
  laboratory test
  letter
  male
  melanoma (drug therapy)
  middle aged
  migraine
  nausea
  neurologic examination
  pain severity
  sigmoidoscopy
  vertigo
CAS REGISTRY NUMBERS
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  dexamethasone (50-02-2)
  follitropin (9002-68-0)
  hydrocortisone (50-23-7)
  ipilimumab (477202-00-9)
  luteinizing hormone (39341-83-8, 9002-67-9)
  prednisone (53-03-2)
  prolactin (12585-34-1, 50647-00-2, 9002-62-4)
  testosterone (58-22-0)
  testosterone undecanoate (5949-44-0)
  thyrotropin (9002-71-5)
  thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20170063651
PUI
  L614160211
DOI
  10.4103/0028-3886.198182
FULL TEXT LINK
  http://dx.doi.org/10.4103/0028-3886.198182
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 19
TITLE
  Case of hypophysitis caused by nivolumab
AUTHOR NAMES
  Ishikawa M.
  Oashi K.
AUTHOR ADDRESSES
  (Ishikawa M., m-ishikawa@cancer-c.pref.saitama.jp; Oashi K.) Department of 
Dermatology, Saitama Cancer Center, Saitama, Japan.
CORRESPONDENCE ADDRESS
  M. Ishikawa, Department of Dermatology, Saitama Cancer Center, Saitama, 
Japan. Email: m-ishikawa@cancer-c.pref.saitama.jp
SOURCE
  Journal of Dermatology (2017) 44:1 (109-110). Date of Publication: 1 Jan 
2017
ISSN
  1346-8138 (electronic)
  0385-2407
BOOK PUBLISHER
  Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  corticotropin (endogenous compound)
  dacarbazine (drug therapy)
  hydrocortisone (drug therapy, endogenous compound, oral drug administration)
  hydrocortisone sodium succinate (drug combination, drug therapy)
  oxygen (drug combination, drug therapy, inhalational drug administration)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypophysitis (drug therapy, side effect, diagnosis, drug therapy, side 
effect)
EMTREE MEDICAL INDEX TERMS
  adrenal insufficiency (drug therapy)
  adrenal metastasis
  adult
  anorexia
  body weight loss
  case report
  depressed blood pressure
  drug dose increase
  drug withdrawal
  human
  hypothyroidism (side effect)
  infusion related reaction (drug therapy, side effect)
  interstitial pneumonia (side effect)
  letter
  malaise
  male
  melanoma (drug therapy)
  middle aged
  multiple cycle treatment
  myalgia
  nausea
  nuclear magnetic resonance imaging
CAS REGISTRY NUMBERS
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  dacarbazine (4342-03-4)
  hydrocortisone (50-23-7)
  hydrocortisone sodium succinate (125-04-2, 2203-97-6)
  nivolumab (946414-94-4)
  oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160405458
MEDLINE PMID
  27178147 (http://www.ncbi.nlm.nih.gov/pubmed/27178147)
PUI
  L610556665
DOI
  10.1111/1346-8138.13437
FULL TEXT LINK
  http://dx.doi.org/10.1111/1346-8138.13437
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 20
TITLE
  Pituitary Dysfunction: A Case Series of Immune Checkpoint Inhibitor–Related 
Hypophysitis in an Emergency Department
AUTHOR NAMES
  Miller A.H.
  Brock P.
  Jim Yeung S.-C.
AUTHOR ADDRESSES
  (Miller A.H.; Brock P.; Jim Yeung S.-C.) Department of Emergency Medicine, 
University of Texas MD Anderson Cancer Center, Houston, United States.
SOURCE
  Annals of Emergency Medicine (2016) 68:2 (249-250). Date of Publication: 1 
Aug 2016
ISSN
  1097-6760 (electronic)
  0196-0644
BOOK PUBLISHER
  Mosby Inc., customerservice@mosby.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  antineoplastic agent (drug therapy)
  immune checkpoint inhibitor (drug therapy)
  immunomodulating agent (drug therapy)
EMTREE DRUG INDEX TERMS
  glucocorticoid (drug therapy)
  hydrocortisone sodium succinate (drug therapy, intravenous drug 
administration)
  ipilimumab (adverse drug reaction)
  prolactin (endogenous compound)
  unclassified drug
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypophysitis (drug therapy, side effect, drug therapy, side effect)
EMTREE MEDICAL INDEX TERMS
  adrenal insufficiency
  blood pressure regulation
  cancer chemotherapy
  drug megadose
  emergency physician
  emergency ward
  human
  hyponatremia
  hypopituitarism
  hypothyroidism
  letter
  nuclear magnetic resonance imaging
  priority journal
  prolactin blood level
CAS REGISTRY NUMBERS
  hydrocortisone sodium succinate (125-04-2, 2203-97-6)
  ipilimumab (477202-00-9)
  prolactin (12585-34-1, 50647-00-2, 9002-62-4)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160874514
PUI
  L613479098
DOI
  10.1016/j.annemergmed.2016.03.048
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.annemergmed.2016.03.048
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 21
TITLE
  Late-onset panhypopituitarism in a 72-year-old male patient treated with 
ipilimumab for metastatic melanoma: a case report
AUTHOR NAMES
  Vancieri G.
  Bellia A.
  Lauro D.
AUTHOR ADDRESSES
  (Vancieri G.; Bellia A.; Lauro D., d.lauro@med.uniroma2.it) Division of 
Endocrinology and Diabetology, Department of Systems Medicine, University of 
Rome “Tor Vergata”, Rome, Italy.
CORRESPONDENCE ADDRESS
  D. Lauro, Division of Endocrinology and Diabetology, Department of Systems 
Medicine, University of Rome “Tor Vergata”, Rome, Italy. Email: 
d.lauro@med.uniroma2.it
SOURCE
  Journal of Endocrinological Investigation (2016) 39:7 (805-806). Date of 
Publication: 1 Jul 2016
ISSN
  1720-8386 (electronic)
  0391-4097
BOOK PUBLISHER
  Springer International Publishing
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  corticotropin (endogenous compound)
  cortisone acetate (drug therapy)
  dipeptidyl carboxypeptidase inhibitor
  hydrochlorothiazide
  hydrocortisone (endogenous compound)
  levothyroxine (drug therapy)
  luteinizing hormone (endogenous compound)
  prolactin (endogenous compound)
  somatomedin C (endogenous compound)
  testosterone (endogenous compound)
  testosterone enantate (drug therapy)
  thyrotropin (endogenous compound)
  thyroxine (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autoimmune hypophysitis (side effect, side effect)
  hypopituitarism (drug therapy, side effect, drug therapy, side effect)
  metastatic melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
  aged
  antihypertensive therapy
  cancer immunotherapy
  case report
  computer assisted tomography
  corticotropin blood level
  electrocardiogram
  emergency ward
  fatigue
  hormone substitution
  human
  hydrocortisone blood level
  Italian (citizen)
  letter
  luteinizing hormone blood level
  male
  new-onset atrial fibrillation
  nuclear magnetic resonance imaging
  presyncope
  prolactin blood level
  testosterone blood level
  thyrotropin blood level
  thyroxine blood level
CAS REGISTRY NUMBERS
  corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
  cortisone acetate (50-04-4)
  hydrochlorothiazide (58-93-5)
  hydrocortisone (50-23-7)
  ipilimumab (477202-00-9)
  levothyroxine (51-48-9)
  luteinizing hormone (39341-83-8, 9002-67-9)
  prolactin (12585-34-1, 50647-00-2, 9002-62-4)
  somatomedin C (67763-96-6)
  testosterone (58-22-0)
  testosterone enantate (315-37-7)
  thyrotropin (9002-71-5)
  thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160478209
MEDLINE PMID
  26883763 (http://www.ncbi.nlm.nih.gov/pubmed/26883763)
PUI
  L610967362
DOI
  10.1007/s40618-016-0439-3
FULL TEXT LINK
  http://dx.doi.org/10.1007/s40618-016-0439-3
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 22
TITLE
  A case report of insulin-dependent diabetes as immune-related toxicity of 
pembrolizumab: presentation, management and outcome
AUTHOR NAMES
  Hansen E.
  Sahasrabudhe D.
  Sievert L.
AUTHOR ADDRESSES
  (Hansen E., Elizabeth_hansen@urmc.rochester.edu; Sahasrabudhe D.; Sievert 
L.) University of Rochester Medical Center, 601 Elmwood Avenue, Box 617, 
Rochester, United States.
CORRESPONDENCE ADDRESS
  E. Hansen, University of Rochester Medical Center, 601 Elmwood Avenue, Box 
617, Rochester, United States. Email: Elizabeth_hansen@urmc.rochester.edu
SOURCE
  Cancer Immunology, Immunotherapy (2016) 65:6 (765-767). Date of Publication: 
1 Jun 2016
ISSN
  1432-0851 (electronic)
  0340-7004
BOOK PUBLISHER
  Springer Science and Business Media Deutschland GmbH, info@springer-sbm.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  pembrolizumab (adverse drug reaction)
EMTREE DRUG INDEX TERMS
  alpha2b interferon (drug therapy)
  B Raf kinase (endogenous compound)
  C peptide (endogenous compound)
  dabrafenib (drug combination, drug therapy)
  glucose (endogenous compound)
  glutamate decarboxylase antibody (endogenous compound)
  hemoglobin A1c (endogenous compound)
  interleukin 2 (drug combination, drug therapy)
  ipilimumab (drug combination, drug therapy)
  long acting insulin (drug therapy)
  short acting insulin (drug therapy)
  trametinib (drug combination, drug therapy)
  vemurafenib (drug combination, drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  immunotoxicity (side effect, side effect)
  insulin dependent diabetes mellitus (drug therapy, side effect, diagnosis, 
drug therapy, side effect)
EMTREE MEDICAL INDEX TERMS
  adult
  axillary lymph node
  body weight disorder (side effect)
  body weight gain
  body weight loss
  cancer adjuvant therapy
  cancer combination chemotherapy
  cancer staging
  cancer surgery
  case report
  compassionate use
  cutaneous melanoma (drug therapy, surgery)
  drug megadose
  drug withdrawal
  fatigue (side effect)
  gastroesophageal reflux (side effect)
  gene mutation
  glucose blood level
  hair discoloration (side effect)
  human
  hypothyroidism (side effect)
  letter
  liver tumor (drug therapy)
  lung biopsy
  lymph node dissection
  lymphadenopathy
  male
  metastatic melanoma (drug therapy)
  middle aged
  polydipsia
  polyuria
  priority journal
  rash
  tumor biopsy
  wide excision
CAS REGISTRY NUMBERS
  alpha2b interferon (99210-65-8)
  C peptide (59112-80-0)
  dabrafenib (1195765-45-7, 1195768-06-9)
  glucose (50-99-7, 84778-64-3)
  hemoglobin A1c (62572-11-6)
  interleukin 2 (85898-30-2)
  ipilimumab (477202-00-9)
  pembrolizumab (1374853-91-4)
  trametinib (1187431-43-1, 871700-17-3)
  vemurafenib (918504-65-1)
EMBASE CLASSIFICATIONS
  Dermatology and Venereology (13)
  Cancer (16)
  Immunology, Serology and Transplantation (26)
  Clinical and Experimental Biochemistry (29)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160294004
MEDLINE PMID
  27067877 (http://www.ncbi.nlm.nih.gov/pubmed/27067877)
PUI
  L609833201
DOI
  10.1007/s00262-016-1835-4
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00262-016-1835-4
COPYRIGHT
  Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 23
TITLE
  Determining predictive factors for immune checkpoint inhibitor toxicity: 
Response to Letter to the Editors “A case report of insulin-dependent 
diabetes as immune-related toxicity of pembrolizumab: presentation, 
management and outcome”
AUTHOR NAMES
  Spain L.
  Larkin J.
  Martin-Liberal J.
AUTHOR ADDRESSES
  (Spain L.; Larkin J.) Melanoma Unit, Royal Marsden NHS Foundation Trust, 
Fulham Road, London, United Kingdom.
(Martin-Liberal J., jmartinliberal@gmail.com) Department of Medical 
Oncology, Vall d’Hebron University Hospital, Vall d’Hebron Institute of 
Oncology (VHIO), Pg Vall d’Hebron, 119-129, Barcelona, Spain.
CORRESPONDENCE ADDRESS
  J. Martin-Liberal, Department of Medical Oncology, Vall d’Hebron University 
Hospital, Vall d’Hebron Institute of Oncology (VHIO), Pg Vall d’Hebron, 
119-129, Barcelona, Spain. Email: jmartinliberal@gmail.com
SOURCE
  Cancer Immunology, Immunotherapy (2016) 65:6 (769-770). Date of Publication: 
1 Jun 2016
ISSN
  1432-0851 (electronic)
  0340-7004
BOOK PUBLISHER
  Springer Science and Business Media Deutschland GmbH, info@springer-sbm.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  pembrolizumab (adverse drug reaction)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  immunotoxicity (side effect, side effect)
  insulin dependent diabetes mellitus (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
  colitis
  disease association
  disease course
  genotype
  HLA typing
  human
  insulin dependence
  letter
  outcome assessment
  predictive value
  priority journal
CAS REGISTRY NUMBERS
  pembrolizumab (1374853-91-4)
EMBASE CLASSIFICATIONS
  Immunology, Serology and Transplantation (26)
  Endocrinology (3)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  20160390796
PUI
  L610481095
DOI
  10.1007/s00262-016-1845-2
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00262-016-1845-2
COPYRIGHT
  Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 24
TITLE
  Ipilimumab-induced hypophysitis: Early Australian experience
AUTHOR NAMES
  De Sousa S.M.C.
  Long G.V.
  Tonks K.T.
AUTHOR ADDRESSES
  (De Sousa S.M.C.) Department of Endocrinology, St Vincent's Hospital, 
Sydney, NSW, Australia.
(Long G.V.) Melanoma Institute Australia, Sydney, NSW, Australia.
(Tonks K.T.) Diabetes and Metabolism Division, Garvan Institute of Medical 
Research, Sydney, NSW, Australia.
SOURCE
  Medical Journal of Australia (2014) 201:4 (198-199). Date of Publication: 18 
Aug 2014
ISSN
  1326-5377 (electronic)
  0025-729X
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  cytotoxic T lymphocyte antigen 4 (endogenous compound)
  dexamethasone
  follitropin (endogenous compound)
  hydrocortisone (endogenous compound)
  liothyronine (endogenous compound)
  prednisolone
  testosterone (endogenous compound)
  thyrotropin (endogenous compound)
  thyroxine (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypophysitis (side effect, diagnosis, side effect)
EMTREE MEDICAL INDEX TERMS
  adult
  androgen therapy
  anorexia
  asthenia
  case report
  cell proliferation
  dizziness
  drug dose reduction
  drug megadose
  fatigue
  headache
  human
  hypogonadism
  insulin tolerance test
  letter
  lumbar puncture
  male
  metastatic melanoma (drug therapy)
  nuclear magnetic resonance imaging
  T lymphocyte activation
  tumor growth
  vomiting
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
  follitropin (9002-68-0)
  hydrocortisone (50-23-7)
  ipilimumab (477202-00-9)
  liothyronine (6138-47-2, 6893-02-3)
  prednisolone (50-24-8)
  testosterone (58-22-0)
  thyrotropin (9002-71-5)
  thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
  Cancer (16)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2014554713
MEDLINE PMID
  25164840 (http://www.ncbi.nlm.nih.gov/pubmed/25164840)
PUI
  L373790824
DOI
  10.5694/mja14.00803
FULL TEXT LINK
  http://dx.doi.org/10.5694/mja14.00803
COPYRIGHT
  Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 25
TITLE
  Ipilimumab-induced orbital inflammation resembling graves disease with 
subsequent development of systemic hyperthyroidism from CTLA-4 receptor 
suppression
AUTHOR NAMES
  Borodic G.E.
  Hinkle D.
AUTHOR ADDRESSES
  (Borodic G.E., borodic@aol.com; Hinkle D.)
CORRESPONDENCE ADDRESS
  G.E. Borodic, Harvard Medical School, 1261 Furance Brook Parkway, Quincy, 
MA, United States. Email: borodic@aol.com
SOURCE
  Ophthalmic Plastic and Reconstructive Surgery (2014) 30:1 (83). Date of 
Publication: January-February 2014
ISSN
  0740-9303
  1537-2677 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cytotoxic T lymphocyte antigen 4 (endogenous compound)
  ipilimumab (adverse drug reaction)
EMTREE DRUG INDEX TERMS
  liothyronine (endogenous compound)
  thyroglobulin antibody (endogenous compound)
  thyroid antibody (endogenous compound)
  thyroid peroxidase antibody (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  Graves disease
  hyperthyroidism
  orbit inflammation (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
  anxiety
  body weight loss
  diarrhea (side effect)
  disease course
  heart palpitation (side effect)
  heat intolerance (side effect)
  human
  lethargy (side effect)
  letter
  liothyronine blood level
  priority journal
  unspecified side effect (side effect)
CAS REGISTRY NUMBERS
  ipilimumab (477202-00-9)
  liothyronine (6138-47-2, 6893-02-3)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Ophthalmology (12)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2014071521
MEDLINE PMID
  24398505 (http://www.ncbi.nlm.nih.gov/pubmed/24398505)
PUI
  L372204569
DOI
  10.1097/IOP.0000000000000033
FULL TEXT LINK
  http://dx.doi.org/10.1097/IOP.0000000000000033
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 26
TITLE
  Immune-mediated colitis: Important to recognize and treat
AUTHOR NAMES
  Pocha C.
  Roat J.
  Viskocil K.
AUTHOR ADDRESSES
  (Pocha C., Pocha004@umn.edu; Roat J.; Viskocil K.) University of Minnesota, 
Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, United 
States.
CORRESPONDENCE ADDRESS
  C. Pocha, University of Minnesota, Minneapolis Veterans Affairs Health Care 
System, Minneapolis, MN, United States. Email: Pocha004@umn.edu
SOURCE
  Journal of Crohn's and Colitis (2014) 8:2 (181-182). Date of Publication: 1 
Feb 2014
ISSN
  1873-9946
  1876-4479 (electronic)
BOOK PUBLISHER
  Elsevier, P.O. Box 211, Amsterdam, Netherlands.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  hydrocortisone
  infliximab (drug therapy, intravenous drug administration)
  methylprednisolone (intravenous drug administration)
  prednisone (oral drug administration)
  testosterone
  thyroid hormone
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  hypophysitis (side effect, side effect)
  immunopathology (side effect, side effect)
  pancolitis (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
  adrenal insufficiency (complication)
  aged
  anorexia (side effect)
  bloody diarrhea
  cancer chemotherapy
  case report
  colon ulcer
  colonoscopy
  diarrhea (drug therapy, side effect)
  disease severity
  edema
  erythema
  fatigue (side effect)
  hormone substitution
  human
  hypopituitarism (complication)
  hypothyroidism (complication)
  lamina propria
  letter
  lymphocyte
  male
  metastatic melanoma (drug therapy)
  microscopy
  multiple cycle treatment
  neutrophil
  priority journal
  steroid therapy
DRUG TRADE NAMES
  yervoy
CAS REGISTRY NUMBERS
  hydrocortisone (50-23-7)
  infliximab (170277-31-3)
  ipilimumab (477202-00-9)
  methylprednisolone (6923-42-8, 83-43-2)
  prednisone (53-03-2)
  testosterone (58-22-0)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Immunology, Serology and Transplantation (26)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
  Gastroenterology (48)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2014062485
MEDLINE PMID
  24138785 (http://www.ncbi.nlm.nih.gov/pubmed/24138785)
PUI
  L52813186
DOI
  10.1016/j.crohns.2013.09.019
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.crohns.2013.09.019
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 27
TITLE
  Ipilimumab, a cause of autoimmune hypophysitis
ORIGINAL (NON-ENGLISH) TITLE
  Ipilimumab, una causa de hipofisitis autoinmunitaria
AUTHOR NAMES
  De Hollanda A.
  Aranda G.B.
  Mora M.
  Gaba L.
  Halperin I.
AUTHOR ADDRESSES
  (De Hollanda A., amdehol@clinic.ub.es; Aranda G.B.; Mora M.; Halperin I.) 
Servicio de Endocrinología y Nutrición, Hospital Clínic, Universitat de 
Barcelona, Barcelona, Spain.
(Gaba L.) Servicio de Oncología, Hospital Clínic, Universitat de Barcelona, 
Barcelona, Spain.
CORRESPONDENCE ADDRESS
  A. De Hollanda, Servicio de Endocrinología y Nutrición, Hospital Clínic, 
Universitat de Barcelona, Barcelona, Spain. Email: amdehol@clinic.ub.es
SOURCE
  Endocrinologia y Nutricion (2013) 60:10 (604-606). Date of Publication: 
December 2013
ISSN
  1575-0922
  1579-2021 (electronic)
BOOK PUBLISHER
  Elsevier Doyma, Traversa de Gracia 17-21, Barcelona, Spain.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  autoimmune disease (side effect, side effect)
  hypophysitis (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
  human
  letter
CAS REGISTRY NUMBERS
  ipilimumab (477202-00-9)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Immunology, Serology and Transplantation (26)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  Spanish
EMBASE ACCESSION NUMBER
  2013768633
MEDLINE PMID
  23607982 (http://www.ncbi.nlm.nih.gov/pubmed/23607982)
PUI
  L52545819
DOI
  10.1016/j.endonu.2013.01.007
FULL TEXT LINK
  http://dx.doi.org/10.1016/j.endonu.2013.01.007
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 28
TITLE
  Ipilimumab-induced endocrinopathies: When to start corticosteroids (or not)
AUTHOR NAMES
  Corsello S.M.
  Salvatori R.
  Barnabei A.
  De Vecchis L.
  Marchetti P.
  Torino F.
AUTHOR ADDRESSES
  (Corsello S.M., corsello.sm@mclink.it) Endocrinology Unit, Università 
Cattolica, Rome, Italy.
(Salvatori R.) Pituitary Center, Division of Endocrinology, Johns Hopkins 
University School of Medicine, Baltimore MD, United States.
(Barnabei A.) Endocrinology Unit, Regina Elena National Cancer Institute, 
Rome, Italy.
(De Vecchis L.; Torino F.) Department of Systems Medicine, Tor Vergata 
University of Rome, Rome, Italy.
(Marchetti P.) Department of Clinical and Molecular Medicine, Sant'Andrea 
Hospital, Sapienza University of Rome, Rome, Italy.
CORRESPONDENCE ADDRESS
  S.M. Corsello, Endocrinology Unit, Università Cattolica, Rome, Italy. Email: 
corsello.sm@mclink.it
SOURCE
  Cancer Chemotherapy and Pharmacology (2013) 72:2 (489-490). Date of 
Publication: August 2013
ISSN
  0344-5704
  1432-0843 (electronic)
BOOK PUBLISHER
  Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  ipilimumab (adverse drug reaction)
EMTREE DRUG INDEX TERMS
  dexamethasone (drug dose, drug therapy, oral drug administration)
  methylprednisolone (drug therapy, intravenous drug administration)
  prednisone (drug therapy, oral drug administration)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  endocrine disease (drug therapy, side effect, drug therapy, prevention, side 
effect)
EMTREE MEDICAL INDEX TERMS
  adrenal insufficiency (prevention, side effect)
  cancer chemotherapy
  corticosteroid therapy
  diarrhea (side effect)
  drug dose reduction
  drug eruption (side effect)
  drug indication
  drug megadose
  drug monitoring
  drug safety
  drug withdrawal
  endocrine ophthalmopathy (side effect)
  hormone substitution
  human
  hypophysitis (drug therapy, prevention, side effect)
  hypopituitarism (prevention)
  letter
  priority journal
  side effect (side effect)
  thyroid disease (side effect)
  thyroid function test
  thyroiditis (side effect)
CAS REGISTRY NUMBERS
  dexamethasone (50-02-2)
  ipilimumab (477202-00-9)
  methylprednisolone (6923-42-8, 83-43-2)
  prednisone (53-03-2)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Cancer (16)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013480638
MEDLINE PMID
  23779068 (http://www.ncbi.nlm.nih.gov/pubmed/23779068)
PUI
  L52639604
DOI
  10.1007/s00280-013-2213-y
FULL TEXT LINK
  http://dx.doi.org/10.1007/s00280-013-2213-y
COPYRIGHT
  Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 29
TITLE
  Re: Drug-induced Graves disease From CTLA-4 receptor suppression
AUTHOR NAMES
  Sohrab M.A.
  Desai R.U.
  Chambers C.B.
  Lissner G.S.
AUTHOR ADDRESSES
  (Sohrab M.A., mahsa-sohrab@fsm.northwestern.edu; Desai R.U.; Chambers C.B.; 
Lissner G.S.) Department of Ophthalmology, Northwestern University, 645 
North Michigan Avenue, Chicago, IL 60611, United States.
CORRESPONDENCE ADDRESS
  M.A. Sohrab, Department of Ophthalmology, Northwestern University, 645 North 
Michigan Avenue, Chicago, IL 60611, United States. Email: 
mahsa-sohrab@fsm.northwestern.edu
SOURCE
  Ophthalmic Plastic and Reconstructive Surgery (2013) 29:3 (239-240). Date of 
Publication: May-June 2013
ISSN
  0740-9303
  1537-2677 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cytotoxic T lymphocyte antigen 4 (endogenous compound)
  ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
  e 1608
  unclassified drug
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug induced disease
  Graves disease (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
  endocrine ophthalmopathy
  human
  letter
  metastatic melanoma (drug therapy)
  priority journal
  uvea melanoma
  visual acuity
DRUG TRADE NAMES
  e 1608
CAS REGISTRY NUMBERS
  ipilimumab (477202-00-9)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Ophthalmology (12)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013436832
MEDLINE PMID
  23652294 (http://www.ncbi.nlm.nih.gov/pubmed/23652294)
PUI
  L369300266
DOI
  10.1097/IOP.0b013e3182895795
FULL TEXT LINK
  http://dx.doi.org/10.1097/IOP.0b013e3182895795
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 30
TITLE
  Reply Re: Drug-induced Graves disease from CTLA-4 receptor suppression
AUTHOR NAMES
  Borodic G.E.
  Hinkle D.M.
AUTHOR ADDRESSES
  (Borodic G.E., borodic@aol.com; Hinkle D.M.) Harvard Medical School, Quincy, 
MA 02169, United States.
CORRESPONDENCE ADDRESS
  G.E. Borodic, Harvard Medical School, Quincy, MA 02169, United States. 
Email: borodic@aol.com
SOURCE
  Ophthalmic Plastic and Reconstructive Surgery (2013) 29:3 (241). Date of 
Publication: May-June 2013
ISSN
  0740-9303
  1537-2677 (electronic)
BOOK PUBLISHER
  Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327, 
Philadelphia, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
  cytotoxic T lymphocyte antigen 4 (endogenous compound)
  ipilimumab (adverse drug reaction)
  T lymphocyte receptor (endogenous compound)
EMTREE DRUG INDEX TERMS
  CD40 antigen (endogenous compound)
  non receptor protein tyrosine phosphatase 22 (endogenous compound)
  thyroglobulin antibody (endogenous compound)
  thyroid hormone (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
  drug induced disease
  endocrine ophthalmopathy (side effect, etiology, side effect)
  gene repression
EMTREE MEDICAL INDEX TERMS
  gene mutation
  genetic association
  genetic polymorphism
  human
  insulin dependent diabetes mellitus
  letter
  primary biliary cirrhosis
  priority journal
  T lymphocyte activation
CAS REGISTRY NUMBERS
  ipilimumab (477202-00-9)
EMBASE CLASSIFICATIONS
  Endocrinology (3)
  Ophthalmology (12)
  Immunology, Serology and Transplantation (26)
  Drug Literature Index (37)
  Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
  English
EMBASE ACCESSION NUMBER
  2013436833
MEDLINE PMID
  23652295 (http://www.ncbi.nlm.nih.gov/pubmed/23652295)
PUI
  L369300267
DOI
  10.1097/IOP.0b013e31828957c3
FULL TEXT LINK
  http://dx.doi.org/10.1097/IOP.0b013e31828957c3
COPYRIGHT
  Copyright 2014 Elsevier B.V., All rights reserved.