Estimation of genetic model parameters: Variables correlated with a quantitative phenotype exhibiting major locus inheritance
dc.contributor.author | Hasstedt, Sandra J. | en_US |
dc.contributor.author | Moll, Patricia P. | en_US |
dc.contributor.author | Rao, D. C. | en_US |
dc.date.accessioned | 2013-12-04T18:57:42Z | |
dc.date.available | 2013-12-04T18:57:42Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Hasstedt, Sandra J.; Moll, Patricia P.; Rao, D. C. (1989). "Estimation of genetic model parameters: Variables correlated with a quantitative phenotype exhibiting major locus inheritance." Genetic Epidemiology 6(2): 319-332. <http://hdl.handle.net/2027.42/101835> | en_US |
dc.identifier.issn | 0741-0395 | en_US |
dc.identifier.issn | 1098-2272 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/101835 | |
dc.description.abstract | A major locus that is detected through its effect on one phenotype (a primary trait) may also affect other quantitative phenotypes or qualitative disease endpoints (secondary traits). The pattern of effects for the mutant allele. The effects are directly estimable when “measured genotypes” or a tightly linked marker allow unambiguous assignment of major locus genotypes. When genotype assignments are ambiguous for a major locus detected through its effect on a quantitative primary trait, we propose estimators using genotypic probabilities. Making certain reasonable assumptions, we demonstrate asymptotic unbiasedness of these genotypic probability estimators of the genotypic means and variances for either the quantitative primary or secondary traits, of the covariances between quantitative primary and secondary traits, and of prevalences for the secondary qualitative traits. An important application of genotypic probability estimators is to define an effect of a major locus that cannot be detected upon analysis of the variable; for example, major locus effects may be defined for hypertension or blood pressure as secondary traits, but not detected as primary traits. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Maximum Likelihood Estimators | en_US |
dc.subject.other | Likelihood Analysis | en_US |
dc.subject.other | Genotypic Probability Estimators | en_US |
dc.subject.other | Pleiotropic Gene Effects | en_US |
dc.subject.other | Bivariate Phenotypes | en_US |
dc.title | Estimation of genetic model parameters: Variables correlated with a quantitative phenotype exhibiting major locus inheritance | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Epidemiology and Human Genetics, University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationother | Department of Human Genetics, University of Utah, Salt Lake City | en_US |
dc.identifier.pmid | 2721927 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/101835/1/1370060203_ftp.pdf | |
dc.identifier.doi | 10.1002/gepi.1370060203 | en_US |
dc.identifier.source | Genetic Epidemiology | en_US |
dc.identifier.citedreference | MacLean CJ, Morton NE, Elston RC, Yee S ( 1976 ): Skewness in commingled distributions. Biometrics 32: 695 – 699. | en_US |
dc.identifier.citedreference | Hasstedt SJ, Ramirez ME, Kuida H, Williams RR ( 1989a ): Recessive inheritance of a relative fat pattern (submitted for publication). | en_US |
dc.identifier.citedreference | Hasstedt SJ, Wu LL, Kuida H, Williams RR ( 1989b ):Recessive inheritance of a high number of sodium pump sites associated with obesity, hypertension and diabetes. Am J Med Genet,(in press). | en_US |
dc.identifier.citedreference | Hewett‐Emmett D, Bertin TK, Hanis CL ( 1987 ): A micromethod for typing the human apolipoprotein E polymorphism: Effects of apo E phenotypes on levels of and correlations between apolipoproteins, lipoproteins and lipids in Mexican‐American females (Abstract). Am J Hum Genet 41: A7. | en_US |
dc.identifier.citedreference | Hilton PJ ( 1986 ): Cellular sodium transport in essential hypertension. N Engl J Med 314: 222 – 229. | en_US |
dc.identifier.citedreference | Hunt SC, Williams RR, Smith JB, Ash KO ( 1986 ): Associations of three erythrocyte cation transport systems with plasma lipids in Utah subjects. Hypertension 8: 30 – 36. | en_US |
dc.identifier.citedreference | Kan YW, Dozy AM ( 1978 ): Polymorphism of DNA sequence adjacent to human β‐globin structural gene: Relationship to sickle mutation. Proc Natl Acad Sci USA 75: 5631 – 5635. | en_US |
dc.identifier.citedreference | Karlin S, Williams PT ( 1984 ): Permutation methods for the structured exploratory data analysis (SEDA) of familial trait values. Am J Hum Genet 36: 873 – 898. | en_US |
dc.identifier.citedreference | Lalouel JM, Le Mignon L, Simon M, Fauchet R, Bourel M, Rao DC, Morton NE ( 1985 ): Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information. Am J Hum Genet 37: 700 – 718. | en_US |
dc.identifier.citedreference | Leppert MF, Hasstedt SJ, Holm T, O'Connell P, Wu L, Ash O, Williams RR, White R ( 1986 ): A DNA probe for the LDL receptor gene is tightly linked to hypercholesterolemia in a pedigree with early coronary disease. Am J Hum Genet 39: 300 – 306. | en_US |
dc.identifier.citedreference | Leppert M, Breslow JL, Wu L, Hasstedt S, O'Connell P, Lathrop M, Williams RR, White R, Lalouel J‐M ( 1988 ): Inference of a molecular defect of apolipoprotein B in hypobetalipoproteinemia by linkage analysis in a large kindred. J Clin Invest 82: 847 – 851. | en_US |
dc.identifier.citedreference | Martin NG, Eaves LJ ( 1977 ): The genetical analysis of covariance structure. Heredity 38: 79 – 95. | en_US |
dc.identifier.citedreference | McGue M ( 1983 ): Bivariate path analysis of plasma lipids. Hum Hered 33: 145 – 152. | en_US |
dc.identifier.citedreference | McGue M, Rao DC, Reich T, Laskarzewski P, Glueck CJ, Russell JM ( 1983 ): The Cincinnati Lipid Research Clinic Family Study. Bivariate path analyses of lipoprotein concentrations. Genet Res Camb 42: 117 – 135. | en_US |
dc.identifier.citedreference | Moll PP, Sing CF, Brewer GJ, Gilroy TE ( 1978 ): Multivariate analysis of the genetic effects on red cell blood glycolysis. In Brewer, GJ ed:“ The Red Cell.” Progress in Clinical and Biological Research,Vol 21. New York: Alan R. Liss, Inc.,pp 385 – 405. | en_US |
dc.identifier.citedreference | Morton NE, MacLean CJ ( 1974 ): Analysis of family resemblance. III. Complex segregation of quantitative traits. Am J Hum Genet 26: 489 – 503. | en_US |
dc.identifier.citedreference | Morton NE, Gulbrandsen CL. Rhoads GG. Kagan A. Lew R ( 1978 ): Major loci for lipoprotein concentrations. Am J Hum Genet 30: 583 – 589. | en_US |
dc.identifier.citedreference | Morton NE, Rao DC, Lalouel JM ( 1983 ):“ Methods in Genetic Epidemiology.” New York: Karger,pp 96 – 97. | en_US |
dc.identifier.citedreference | Odenheimer D ( 1985 ): An evaluation of complex segregation analysis in identifying an individual's genotype at a major locus.Ph. D. Dissertation, University of Michigan, Ann Arbor. | en_US |
dc.identifier.citedreference | Schwartz AG, Boehnke M, Moll PP ( 1988 ): The family risk index as a measure of familial heterogeneity of cancer risk: A population based study in metropolitan Detroit. Am J Epidemiol 128: 524 – 535. | en_US |
dc.identifier.citedreference | Sing CF, Davignon J ( 1985 ): Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 37: 268 – 285. | en_US |
dc.identifier.citedreference | Sing CF, Boerwinkle E, Turner ST ( 1986 ): Genetics of primary hypertension. Clin Exp Hypertens [A] 8: 623 – 651. | en_US |
dc.identifier.citedreference | Sing CF, Boerwinkle E, Moll PP, Templeton AR ( 1988 ): Characterization of genes affecting quantitative traits. In Weir BS, Eisen EJ, Goodman MM, Namkoong G (eds):“ Proceedings of the Second International Conference on Quantitative Genetics.” Sunderland, MA: Sinauer,pp 250 – 269. | en_US |
dc.identifier.citedreference | Vogler GP ( 1985 ): Multivariate path analysis of familial resemblance. Genet Epidemiol 2: 35 – 53. | en_US |
dc.identifier.citedreference | Vogler GP, DeFries JC ( 1985 ): Bivariate path analysis of familial resemblance for reading ability and symbol processing speed. Behav Genet 15: 111 – 121. | en_US |
dc.identifier.citedreference | Williams RR, Hunt SC, Kuida H, Smith JB, Ash KO ( 1983 ): Sodium‐lithium countertransport in erythrocytes of hypertension prone families in Utah. Am J Epidemiol 118: 338 – 344. | en_US |
dc.identifier.citedreference | Williams RR, Hasstedt SJ, Wilson DE, Ash KO, Yanowitz FF, Reiber GE, Kuida H ( 1986 ): Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees. JAMA 255: 219 – 224. | en_US |
dc.identifier.citedreference | Boehnke M, Moll PP, Lange K, Weidman WH, Kottke BA ( 1986 ): Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees. Am J Med Genet 23: 775 – 792. | en_US |
dc.identifier.citedreference | Boerwinkle E, Sing CF ( 1986 ): Bias of the contribution of single‐locus effects to the variance of a quantitative trait. Am J Hum Genet 39: 137 – 144. | en_US |
dc.identifier.citedreference | Boerwinkle E, Chakraborty R, Sing CF ( 1986a ): The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet 50: 181 – 194. | en_US |
dc.identifier.citedreference | Boerwinkle E, Turner ST, Weinshilboum R, Johnson M, Richelson E, Sing CF ( 1986b ): Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population. Genet Epidemiol 3: 365 – 378. | en_US |
dc.identifier.citedreference | Boerwinkle E, Utermann G ( 1988 ): Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. Am J Hum Genet 42: 104 – 112. | en_US |
dc.identifier.citedreference | Boerwinkle E, Visvikis S, Welsh D, Steinmetz J, Hanash SM, Sing CF ( 1987 ): The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in a sample of unrelated individuals. Am J Med Genet 27: 567 – 582. | en_US |
dc.identifier.citedreference | Canessa M, Adragna N, Solomon HS, Connolly TM, Tosteson DC ( 1980 ): Increased sodium‐lithium countertransport in red cells of patients with essential hypertension. N Engl J Med 302: 772 – 776. | en_US |
dc.identifier.citedreference | Colletto GMDD, Krieger H, Magalhaes JR ( 1981 ): Estimates of the genetical and environmental determinants of serum lipid and lipoprotein concentrations in Brazilian twins. Hum Hered 31: 232 – 237. | en_US |
dc.identifier.citedreference | Darlu P, Rao DC, Henrotte JG, Lalouel JM ( 1982 ): Genetic regulation of plasma and red cell magnesium concentrations in man. I. Univariate and bivariate path analysis. Am J Hum Genet 34: 874 – 887. | en_US |
dc.identifier.citedreference | Edgington ES ( 1987 ):“ Randomization Tests,” 2nd Ed. New York: Marcel Dekker, Inc. | en_US |
dc.identifier.citedreference | Edwards AWF ( 1972 ):“ Likelihood.” Cambridge: Cambridge University Press. | en_US |
dc.identifier.citedreference | Elston RC, Namboodiri KK, Glueck CJ, Fallat R, Tsang R, Leuba V ( 1975 ): Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred. Ann Hum Genet 39: 67 – 87. | en_US |
dc.identifier.citedreference | Elston RC, Stewart J ( 1971 ): A general model for the genetic analysis of pedigree data. Hum Hered 21: 523 – 542. | en_US |
dc.identifier.citedreference | Goldin LR, Elston RC, Graham JB, Miller CH ( 1980 ): Genetic analysis of von Willebrand's disease in two large pedigrees: A multivariate approach. Am J Med Genet 6: 279 – 293. | en_US |
dc.identifier.citedreference | Hanis CL ( 1981 ): Multivariate models for human genetic analyses: Development and application to systolic blood pressure and weight.PhD Dissertation, University of Michigan, Ann Arbor. | en_US |
dc.identifier.citedreference | Hanis CL, Sing CF, Clarke WR, Schrott HG ( 1983 ): Multivariate models for human genetic analysis: Aggregation, coaggregation, and tracking of systolic blood pressure and weight. Am J Hum Genet 35: 1196 – 1210. | en_US |
dc.identifier.citedreference | Hasstedt SJ ( 1989 ): Pap: Pedigree Analysis Package, Rev. 3. Department of Human Genetics, University of Utah, Salt Lake City. | en_US |
dc.identifier.citedreference | Hasstedt SJ, Wu L, Williams RR ( 1987 ): Major locus inheritance of apolipoprotein B in Utah pedigrees. Genet Epidemiol 4: 67 – 76. | en_US |
dc.identifier.citedreference | Hasstedt SJ, Hunt SC, Wu LL, Williams RR ( 1988a ): The inheritance of intraerythrocytic sodium level. Am J Med Genet 29: 193 – 203. | en_US |
dc.identifier.citedreference | Hasstedt SJ, Wu LL, Ash KO, Kuida H, Williams RR ( 1988b ): Hypertension and sodium‐lithium countertransport in Utah pedigrees: Evidence for major locus inheritance. Am J Hum Genet 43: 14 – 22. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.