Show simple item record

Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis

dc.contributor.authorQiu, Quanen_US
dc.contributor.authorZheng, Zeen_US
dc.contributor.authorChang, Linen_US
dc.contributor.authorZhao, Yuan‐sien_US
dc.contributor.authorTan, Canen_US
dc.contributor.authorDandekar, Adityaen_US
dc.contributor.authorZhang, Zhengen_US
dc.contributor.authorLin, Zhenghongen_US
dc.contributor.authorGui, Mingen_US
dc.contributor.authorLi, Xiuen_US
dc.contributor.authorZhang, Tongshuaien_US
dc.contributor.authorKong, Qingfeien_US
dc.contributor.authorLi, Hulunen_US
dc.contributor.authorChen, Shaen_US
dc.contributor.authorChen, Anen_US
dc.contributor.authorKaufman, Randal Jen_US
dc.contributor.authorYang, Wei‐leien_US
dc.contributor.authorLin, Hui‐kuanen_US
dc.contributor.authorZhang, Donnaen_US
dc.contributor.authorPerlman, Harrisen_US
dc.contributor.authorThorp, Edwarden_US
dc.contributor.authorZhang, Kezhongen_US
dc.contributor.authorFang, Deyuen_US
dc.date.accessioned2014-01-08T20:34:57Z
dc.date.available2014-11-03T16:20:37Zen_US
dc.date.issued2013-09-11en_US
dc.identifier.citationQiu, Quan; Zheng, Ze; Chang, Lin; Zhao, Yuan‐si ; Tan, Can; Dandekar, Aditya; Zhang, Zheng; Lin, Zhenghong; Gui, Ming; Li, Xiu; Zhang, Tongshuai; Kong, Qingfei; Li, Hulun; Chen, Sha; Chen, An; Kaufman, Randal J; Yang, Wei‐lei ; Lin, Hui‐kuan ; Zhang, Donna; Perlman, Harris; Thorp, Edward; Zhang, Kezhong; Fang, Deyu (2013). "Tollâ like receptorâ mediated IRE1α activation as a therapeutic target for inflammatory arthritis." The EMBO Journal 32(18): 2477-2490. <http://hdl.handle.net/2027.42/102185>en_US
dc.identifier.issn0261-4189en_US
dc.identifier.issn1460-2075en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/102185
dc.publisherJohn Wiley & Sons, Ltden_US
dc.subject.otherUbiquitinationen_US
dc.subject.otherInflammationen_US
dc.subject.otherIRE1en_US
dc.subject.otherTRAF6en_US
dc.titleToll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/1/embj2013183-sup-0004-SourceData-S4.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/2/embj2013183-sup-0001.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/3/embj2013183-sup-0008-SourceData-S8.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/4/embj2013183-sup-0005-SourceData-S5.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/5/embj2013183-sup-0001-SourceData-S1.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/6/embj2013183-sup-0009-SourceData-S9.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/7/embj2013183-sup-0006-SourceData-S6.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/8/embj2013183-sup-0002-SourceData-S2.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/9/embj2013183-sup-0010-SourceData-S10.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/10/embj2013183-sup-0007-SourceData-S7.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/11/embj2013183-sup-0003-SourceData-S3.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/12/embj2013183.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/13/embj2013183.reviewer_comments.pdf
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/102185/14/embj2013183-sup-0011-SourceData-S11.pdf
dc.identifier.doi10.1038/emboj.2013.183en_US
dc.identifier.sourceThe EMBO Journalen_US
dc.identifier.citedreferenceSalghetti SE, Caudy AA, Chenoweth JG, Tansey WP ( 2001 ) Regulation of transcriptional activation domain function by ubiquitin. Science 293: 1651 – 1653en_US
dc.identifier.citedreferenceO'Neill LA ( 2003 ) Therapeutic targeting of Toll‐like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 3: 396 – 403en_US
dc.identifier.citedreferenceOhashi K, Burkart V, Flohe S, Kolb H ( 2000 ) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll‐like receptor‐4 complex. J Immunol 164: 558 – 561en_US
dc.identifier.citedreferenceOslowski CM, Hara T, O'Sullivan‐Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F ( 2012 ) Thioredoxin‐interacting protein mediates ER stress‐induced beta cell death through initiation of the inflammasome. Cell Metab 16: 265 – 273en_US
dc.identifier.citedreferenceOspelt C, Brentano F, Rengel Y, Stanczyk J, Kolling C, Tak PP, Gay RE, Gay S, Kyburz D ( 2008 ) Overexpression of toll‐like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll‐like receptor expression in early and longstanding arthritis. Arthritis Rheum 58: 3684 – 3692en_US
dc.identifier.citedreferencePan R, Gao XH, Li Y, Xia YF, Dai Y ( 2010 ) Anti‐arthritic effect of scopoletin, a coumarin compound occurring in Erycibe obtusifolia Benth stems, is associated with decreased angiogenesis in synovium. Fundam Clin Pharmacol 24: 477 – 490en_US
dc.identifier.citedreferencePisetsky DS, Erlandsson‐Harris H, Andersson U ( 2008 ) High‐mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 10: 209en_US
dc.identifier.citedreferencePochet L, Frederick R, Masereel B ( 2004 ) Coumarin and isocoumarin as serine protease inhibitors. Curr Pharm Des 10: 3781 – 3796en_US
dc.identifier.citedreferenceProost P, Verpoest S, Van de Borne K, Schutyser E, Struyf S, Put W, Ronsse I, Grillet B, Opdenakker G, Van Damme J ( 2004 ) Synergistic induction of CXCL9 and CXCL11 by Toll‐like receptor ligands and interferon‐gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids. J Leukoc Biol 75: 777 – 784en_US
dc.identifier.citedreferenceQi L, Yang L, Chen H ( 2011 ) Detecting and quantitating physiological endoplasmic reticulum stress. Methods Enzymol 490: 137 – 146en_US
dc.identifier.citedreferenceQiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y ( 2010 ) A crucial role for RACK1 in the regulation of glucose‐stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal 3: ra7en_US
dc.identifier.citedreferenceRoelofs MF, Boelens WC, Joosten LA, Abdollahi‐Roodsaz S, Geurts J, Wunderink LU, Schreurs BW, van den Berg WB, Radstake TR ( 2006 ) Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 176: 7021 – 7027en_US
dc.identifier.citedreferenceRostom S, Mengat M, Lahlou R, Hari A, Bahiri R, Hajjaj‐Hassouni N ( 2013 ) Metabolic syndrome in rheumatoid arthritis: case control study. BMC Musculoskelet Disorders 14: 147en_US
dc.identifier.citedreferenceScatizzi JC, Hutcheson J, Pope RM, Firestein GS, Koch AE, Mavers M, Smason A, Agrawal H, Haines GK 3rd, Chandel NS, Hotchkiss RS, Perlman H ( 2010 ) Bim‐Bcl‐2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum 62: 441 – 451en_US
dc.identifier.citedreferenceSchmutz C, Cartwright A, Williams H, Haworth O, Williams JH, Filer A, Salmon M, Buckley CD, Middleton J ( 2010 ) Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation. Arthritis Res Ther 12: R161en_US
dc.identifier.citedreferenceSeibl R, Birchler T, Loeliger S, Hossle JP, Gay RE, Saurenmann T, Michel BA, Seger RA, Gay S, Lauener RP ( 2003 ) Expression and regulation of Toll‐like receptor 2 in rheumatoid arthritis synovium. Am J Pathol 162: 1221 – 1227en_US
dc.identifier.citedreferenceSha H, He Y, Yang L, Qi L ( 2011 ) Stressed out about obesity: IRE1alpha‐XBP1 in metabolic disorders. Trends Endocrinol Metab 22: 374 – 381en_US
dc.identifier.citedreferenceShen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ ( 2001 ) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107: 893 – 903en_US
dc.identifier.citedreferenceShin EM, Zhou HY, Guo LY, Kim JA, Lee SH, Merfort I, Kang SS, Kim HS, Kim S, Kim YS ( 2008 ) Anti‐inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS‐stimulated RAW264.7 macrophages. Int Immunopharmacol 8: 1524 – 1532en_US
dc.identifier.citedreferenceShin YJ, Han SH, Kim DS, Lee GH, Yoo WH, Kang YM, Choi JY, Lee YC, Park SJ, Jeong SK, Kim HT, Chae SW, Jeong HJ, Kim HR, Chae HJ ( 2010 ) Autophagy induction and CHOP under‐expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress. Arthritis Res Ther 12: R19en_US
dc.identifier.citedreferenceTurner MJ, Sowders DP, DeLay ML, Mohapatra R, Bai S, Smith JA, Brandewie JR, Taurog JD, Colbert RA ( 2005 ) HLA‐B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. J Immunol 175: 2438 – 2448en_US
dc.identifier.citedreferenceUrano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D ( 2000 ) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664 – 666en_US
dc.identifier.citedreferencevan Beijnum JR, Buurman WA, Griffioen AW ( 2008 ) Convergence and amplification of toll‐like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis 11: 91 – 99en_US
dc.identifier.citedreferenceVanags D, Williams B, Johnson B, Hall S, Nash P, Taylor A, Weiss J, Feeney D ( 2006 ) Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double‐blind randomised trial. Lancet 368: 855 – 863en_US
dc.identifier.citedreferenceVaroga D, Paulsen F, Mentlein R, Fay J, Kurz B, Schutz R, Wruck C, Goldring MB, Pufe T ( 2006 ) TLR‐2‐mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease. J Pathol 210: 315 – 324en_US
dc.identifier.citedreferenceWahamaa H, Schierbeck H, Hreggvidsdottir HS, Palmblad K, Aveberger AC, Andersson U, Harris HE ( 2011 ) High mobility group box protein 1 in complex with lipopolysaccharide or IL‐1 promotes an increased inflammatory phenotype in synovial fibroblasts. Arthritis Res Ther 13: R136en_US
dc.identifier.citedreferenceWang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ ( 2001 ) TAK1 is a ubiquitin‐dependent kinase of MKK and IKK. Nature 412: 346 – 351en_US
dc.identifier.citedreferenceWipke BT, Allen PM ( 2001 ) Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 167: 1601 – 1608en_US
dc.identifier.citedreferenceYang L, Xue Z, He Y, Sun S, Chen H, Qi L ( 2010 ) A Phos‐tag‐based approach reveals the extent of physiological endoplasmic reticulum stress. PLoS One 5: e11621en_US
dc.identifier.citedreferenceYang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK ( 2009 ) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134 – 1138en_US
dc.identifier.citedreferenceYao R, Fu Y, Li S, Tu L, Zeng X, Kuang N ( 2011 ) Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen‐induced arthritis. Eur J Pharmacol 670: 286 – 294en_US
dc.identifier.citedreferenceYavuz S, Elbir Y, Tulunay A, Eksioglu‐Demiralp E, Direskeneli H ( 2008 ) Differential expression of toll‐like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesis. Rheumatol Int 28: 401 – 406en_US
dc.identifier.citedreferenceYesilada E, Taninaka H, Takaishi Y, Honda G, Sezik E, Momota H, Ohmoto Y, Taki T ( 2001 ) In vitro inhibitory effects of Daphne oleoides ssp. oleoides on inflammatory cytokines and activity‐guided isolation of active constituents. Cytokine 13: 359 – 364en_US
dc.identifier.citedreferenceYoo SA, You S, Yoon HJ, Kim DH, Kim HS, Lee K, Ahn JH, Hwang D, Lee AS, Kim KJ, Park YJ, Cho CS, Kim WU ( 2012 ) A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med 209: 871 – 886en_US
dc.identifier.citedreferenceZhang K ( 2010 ) Integration of ER stress, oxidative stress and the inflammatory response in health and disease. Int J Clin Exp Med 3: 33 – 40en_US
dc.identifier.citedreferenceZhang K, Kaufman RJ ( 2006 ) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66: S102 – S109en_US
dc.identifier.citedreferenceZhang K, Kaufman RJ ( 2008 ) From endoplasmic‐reticulum stress to the inflammatory response. Nature 454: 455 – 462en_US
dc.identifier.citedreferenceZhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ ( 2011 ) The unfolded protein response transducer IRE1alpha prevents ER stress‐induced hepatic steatosis. EMBO J 30: 1357 – 1375en_US
dc.identifier.citedreferenceZhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ ( 2005 ) The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest 115: 268 – 281en_US
dc.identifier.citedreferenceAsea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK ( 2002 ) Novel signal transduction pathway utilized by extracellular HSP70: role of toll‐like receptor (TLR) 2 and TLR4. J Biol Chem 277: 15028 – 15034en_US
dc.identifier.citedreferenceBrenner DA, O'Hara M, Angel P, Chojkier M, Karin M ( 1989 ) Prolonged activation of jun and collagenase genes by tumour necrosis factor‐alpha. Nature 337: 661 – 663en_US
dc.identifier.citedreferenceBruhns P, Samuelsson A, Pollard JW, Ravetch JV ( 2003 ) Colony‐stimulating factor‐1‐dependent macrophages are responsible for IVIG protection in antibody‐induced autoimmune disease. Immunity 18: 573 – 581en_US
dc.identifier.citedreferenceCalfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D ( 2002 ) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP‐1 mRNA. Nature 415: 92 – 96en_US
dc.identifier.citedreferenceCao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B ( 2008 ) Toll‐like receptor‐mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin‐sensitive PI(3)K‐mTOR‐p70S6K pathway. Nat Immunol 9: 1157 – 1164en_US
dc.identifier.citedreferenceChang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL ( 2004 ) Modulation of macrophage differentiation and activation by decoy receptor 3. J Leukoc Biol 75: 486 – 494en_US
dc.identifier.citedreferenceClausen BE, Burkhardt C, Reith W, Renkawitz R, Forster I ( 1999 ) Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8: 265 – 277en_US
dc.identifier.citedreferenceColbert RA, DeLay ML, Layh‐Schmitt G, Sowders DP ( 2009 ) HLA‐B27 misfolding and spondyloarthropathies. Adv Exp Med Biol 649: 217 – 234en_US
dc.identifier.citedreferenceCorr M, Crain B ( 2002 ) The role of FcgammaR signaling in the K/BxN serum transfer model of arthritis. J Immunol 169: 6604 – 6609en_US
dc.identifier.citedreferenceCross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP ( 2012 ) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1‐binding small molecule. Proc Natl Acad Sci USA 109: E869 – E878en_US
dc.identifier.citedreferenceDeng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ ( 2000 ) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin‐conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351 – 361en_US
dc.identifier.citedreferenceEgan CE, Sukhumavasi W, Butcher BA, Denkers EY ( 2009 ) Functional aspects of Toll‐like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii. Clin Exp Immunol 156: 17 – 24en_US
dc.identifier.citedreferenceGilliet M, Cao W, Liu YJ ( 2008 ) Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol 8: 594 – 606en_US
dc.identifier.citedreferenceHan D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR ( 2009 ) IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138: 562 – 575en_US
dc.identifier.citedreferenceHarama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A ( 2009 ) A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide‐induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J Immunol 183: 1368 – 1374en_US
dc.identifier.citedreferenceHetz C, Martinon F, Rodriguez D, Glimcher LH ( 2011 ) The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha. Physiol Rev 91: 1219 – 1243en_US
dc.identifier.citedreferenceHollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS ( 2009 ) Regulated Ire1‐dependent decay of messenger RNAs in mammalian cells. J Cell Biol 186: 323 – 331en_US
dc.identifier.citedreferenceHollien J, Weissman JS ( 2006 ) Decay of endoplasmic reticulum‐localized mRNAs during the unfolded protein response. Science 313: 104 – 107en_US
dc.identifier.citedreferenceHotamisligil GS ( 2010 ) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900 – 917en_US
dc.identifier.citedreferenceHuang QQ, Koessler RE, Birkett R, Perlman H, Xing L, Pope RM ( 2013 ) TLR2 deletion promotes arthritis through reduction of IL‐10. J Leukoc Biol 93: 751 – 759en_US
dc.identifier.citedreferenceHuang QQ, Sobkoviak R, Jockheck‐Clark AR, Shi B, Mandelin AM 2nd, Tak PP, Haines GK 3rd, Nicchitta CV, Pope RM ( 2009 ) Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol 182: 4965 – 4973en_US
dc.identifier.citedreferenceIwawaki T, Akai R, Kohno K, Miura M ( 2004 ) A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med 10: 98 – 102en_US
dc.identifier.citedreferenceJacobs JP, Ortiz‐Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C ( 2010 ) Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody‐mediated arthritis in a murine model. Arthritis Rheum 62: 1921 – 1932en_US
dc.identifier.citedreferenceJi H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D ( 2002 ) Arthritis critically dependent on innate immune system players. Immunity 16: 157 – 168en_US
dc.identifier.citedreferenceKaser A, Flak MB, Tomczak MF, Blumberg RS ( 2011 ) The unfolded protein response and its role in intestinal homeostasis and inflammation. Exp Cell Res 317: 2772 – 2779en_US
dc.identifier.citedreferenceKawai T, Akira S ( 2011 ) Toll‐like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34: 637 – 650en_US
dc.identifier.citedreferenceKontogiorgis CA, Savvoglou K, Hadjipavlou‐Litina DJ ( 2006 ) Antiinflammatory and antioxidant evaluation of novel coumarin derivatives. J Enzyme Inhib Med Chem 21: 21 – 29en_US
dc.identifier.citedreferenceKorganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D ( 1999 ) From systemic T cell self‐reactivity to organ‐specific autoimmune disease via immunoglobulins. Immunity 10: 451 – 461en_US
dc.identifier.citedreferenceLee AH, Glimcher LH ( 2009 ) Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci 66: 2835 – 2850en_US
dc.identifier.citedreferenceLee AH, Heidtman K, Hotamisligil GS, Glimcher LH ( 2011 ) Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci USA 108: 8885 – 8890en_US
dc.identifier.citedreferenceLee AH, Scapa EF, Cohen DE, Glimcher LH ( 2008 ) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492 – 1496en_US
dc.identifier.citedreferenceLee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB ( 2002 ) Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297: 1689 – 1692en_US
dc.identifier.citedreferenceLi ZP, Hu JF, Sun MN, Ji HJ, Zhao M, Wu DH, Li GY, Liu G, Chen NH ( 2011 ) Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan‐induced pleurisy in rats. Eur J Pharmacol 661: 118 – 123en_US
dc.identifier.citedreferenceLomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR et al ( 1999 ) TRAF6 deficiency results in osteopetrosis and defective interleukin‐1, CD40, and LPS signaling. Genes Dev 13: 1015 – 1024en_US
dc.identifier.citedreferenceMao C, Dong D, Little E, Luo S, Lee AS ( 2004 ) Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo. Nat Med 10: 1013 – 1014 author reply 1014en_US
dc.identifier.citedreferenceMartinon F, Chen X, Lee AH, Glimcher LH ( 2010 ) TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11: 411 – 418en_US
dc.identifier.citedreferenceMartinon F, Glimcher LH ( 2011 ) Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum. Curr Opin Immunol 23: 35 – 40en_US
dc.identifier.citedreferenceMavers M, Cuda CM, Misharin AV, Gierut AK, Agrawal H, Weber E, Novack DV, Haines GK 3rd, Balomenos D, Perlman H ( 2012 ) Cyclin‐dependent kinase inhibitor p21, via its C‐terminal domain, is essential for resolution of murine inflammatory arthritis. Arthritis Rheum 64: 141 – 152en_US
dc.identifier.citedreferenceMills KH ( 2011 ) TLR‐dependent T cell activation in autoimmunity. Nat Rev Immunol 11: 807 – 822en_US
dc.identifier.citedreferenceMillward TA, Zolnierowicz S, Hemmings BA ( 1999 ) Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 24: 186 – 191en_US
dc.identifier.citedreferenceNundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot‐Handford RP, Briggs MD ( 2010 ) An unfolded protein response is the initial cellular response to the expression of mutant matrilin‐3 in a mouse model of multiple epiphyseal dysplasia. Cell Stress Chaperones 15: 835 – 849en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.